FN Thomson Reuters Web of Science™
VR 1.0
PT S
AU Gupta, N
AF Gupta, Neelam
BE Druy, MA
Crocombe, RA
Bannon, DP
TI Performance Characterization of VNIR & SWIR Spectropolarimetric Imagers
SO NEXT-GENERATION SPECTROSCOPIC TECHNOLOGIES VIII
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Next-Generation Spectroscopic Technologies VIII
CY APR 20-22, 2015
CL Baltimore, MD
SP SPIE
DE Hyperspectral; polarization; spectropolarimetric; imager; VNIR; SWIR;
acousto-optic tunable filter; AOTF; TeO2; Stokes polarization
ID ACOUSTOOPTIC TUNABLE FILTER; CRYSTALS; SYSTEM
AB Two compact prototype spectropolarimetric imagers operating in the visible-near-infrared (VNIR) and shortwave-infrared (SWIR) regions were developed. Each of these imagers uses a noncollinear acousto-optic tunable filter (AOTF) and collects data with four linear incident polarizations-vertical, horizontal and +/- 45 degrees. The spectral region of operation for the first imager is from 450 to 800 nm and the second one from 1000 to 1600 nm. These imagers are field-portable and before field test were characterized for their performance in collecting hyperspectral and full linear polarization signatures. Image cubes of scenes with natural objects were collected and analyzed. Here, we present imaging and spectral analysis results for these imagers.
C1 US Army, Res Lab, Adelphi, MD 20817 USA.
RP Gupta, N (reprint author), US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20817 USA.
NR 27
TC 2
Z9 2
U1 0
U2 1
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-598-8
J9 PROC SPIE
PY 2015
VL 9482
AR 948216
DI 10.1117/12.2177099
PG 11
WC Optics; Spectroscopy
SC Optics; Spectroscopy
GA BD0AF
UT WOS:000357016100033
ER
PT S
AU Martin, MZ
Fox, RV
Miziolek, AW
DeLucia, FC
Andre, N
AF Martin, Madhavi Z.
Fox, Robert V.
Miziolek, Andrzej W.
DeLucia, Frank C., Jr.
Andre, Nicolas
BE Druy, MA
Crocombe, RA
Bannon, DP
TI Spectral Analysis of Rare Earth Elements using Laser-Induced Breakdown
Spectroscopy
SO NEXT-GENERATION SPECTROSCOPIC TECHNOLOGIES VIII
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Next-Generation Spectroscopic Technologies VIII
CY APR 20-22, 2015
CL Baltimore, MD
SP SPIE
DE Laser-induced breakdown spectroscopy; LIBS of rare earth magnets; LIBS
for detection rare earth elements
ID SPECTROMETRY
AB There is growing interest in rapid analysis of rare earth elements (REEs) both due to the need to find new natural sources to satisfy increased demand in their use in various electronic devices, as well as the fact that they are used to estimate actinide masses for nuclear safeguards and nonproliferation. Laser-Induced Breakdown Spectroscopy (LIBS) appears to be a particularly well-suited spectroscopy-based technology to rapidly and accurately analyze the REEs in various matrices at low concentration levels (parts-per-million). Although LIBS spectra of REEs have been reported for a number of years, further work is still necessary in order to be able to quantify the concentrations of various REEs in real-world complex samples. LIBS offers advantages over conventional solution-based radiochemistry in terms of cost, analytical turnaround, waste generation, personnel dose, and contamination risk. Rare earth elements of commercial interest are found in the following three matrix groups: 1) raw ores and unrefined materials, 2) as components in refined products such as magnets, lighting phosphors, consumer electronics (which are mostly magnets and phosphors), catalysts, batteries, etc., and 3) waste/recyclable materials (aka e-waste). LIBS spectra for REEs such as Gd, Nd, and Sm found in rare earth magnets are presented.
C1 [Martin, Madhavi Z.] Oak Ridge Natl Lab, Oak Ridge, TN 37831 USA.
[Fox, Robert V.] Idaho Natl Lab, Idaho Falls, ID 83415 USA.
[Miziolek, Andrzej W.; DeLucia, Frank C., Jr.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Andre, Nicolas] Univ Tennessee, Ctr Renewable Carbon, Knoxville, TN 37831 USA.
RP Martin, MZ (reprint author), Oak Ridge Natl Lab, Oak Ridge, TN 37831 USA.
EM Martinm1@ornl.gov
OI Martin, Madhavi/0000-0002-6677-2180
NR 22
TC 0
Z9 0
U1 3
U2 8
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-598-8
J9 PROC SPIE
PY 2015
VL 9482
AR 94820G
DI 10.1117/12.2178192
PG 8
WC Optics; Spectroscopy
SC Optics; Spectroscopy
GA BD0AF
UT WOS:000357016100011
ER
PT S
AU Sorauf, KJ
Bauer, AJR
Miziolek, AW
De Lucia, FC
AF Sorauf, Kellen J.
Bauer, Amy J. R.
Miziolek, Andrzej W.
De Lucia, Frank C., Jr.
BE Druy, MA
Crocombe, RA
Bannon, DP
TI Spectral Data Analysis Approaches for Improved Provenance Classification
SO NEXT-GENERATION SPECTROSCOPIC TECHNOLOGIES VIII
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Next-Generation Spectroscopic Technologies VIII
CY APR 20-22, 2015
CL Baltimore, MD
SP SPIE
DE laser-induced breakdown spectroscopy (LIBS); provenance analysis;
forensics; discriminant analysis; elemental fingerprinting
ID INDUCED BREAKDOWN SPECTROSCOPY; PLASMA-MASS SPECTROMETRY;
DISCRIMINATION; MINERALS; RESIDUES; EXAMPLE; SENSOR; FIELD
AB In the last 10 years various chemometric methods have been developed and used for the analysis of spectra generated by Laser Induced Breakdown Spectroscopy (LIBS). One of the more successful and proven methods is Partial Least Squares Discriminant Analysis (PLS-DA). Recently PLS-DA was utilized for purposes of provenance of spent brass cartridges and achieved correct classification at around 93% with a false alarm rate of around 5%. The LIBS spectra from the cartridge samples are rich in emission lines from numerous mostly metallic elements comprising the brass and the cited results were based on the analysis of the full broadband high resolution spectra. It was observed that some of the lines were clearly saturated in all spectra, while others were sometimes saturated due to pulse-to-pulse variation. The pulse-to-pulse variation was also evident in the intensity variations of the spectra within cartridges and between cartridges. In order to improve on the accuracy of the classification we have developed some preprocessing strategies including the removal of spectral wavelength ranges susceptible to saturation and normalization techniques to diminish the effects of intensity variations in the spectra. The results indicate incremental improvements when applying additional preprocessing steps to the limit of 100% True Positives and 0% False Positives when utilizing selected wavelengths that are normalized and averaged.
C1 [Sorauf, Kellen J.] Regis Univ, Denver, CO 80221 USA.
[Bauer, Amy J. R.] TSI Inc, Minneapolis, MN USA.
[Miziolek, Andrzej W.; De Lucia, Frank C., Jr.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Sorauf, KJ (reprint author), Regis Univ, Denver, CO 80221 USA.
EM ksorauf@regis.edu
NR 27
TC 0
Z9 0
U1 1
U2 6
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-598-8
J9 PROC SPIE
PY 2015
VL 9482
AR 948212
DI 10.1117/12.2177913
PG 10
WC Optics; Spectroscopy
SC Optics; Spectroscopy
GA BD0AF
UT WOS:000357016100029
ER
PT S
AU Cam, H
AF Cam, Hasan
BE Ternovskiy, IV
Chin, P
TI Risk Assessment by Dynamic Representation of Vulnerability,
Exploitation, and Impact
SO CYBER SENSING 2015
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Cyber Sensing
CY APR 21, 2015
CL Baltimore, MD
SP SPIE
DE Risk assessment; vulnerability; exploitation likelihood and impact;
Markov model; attack state
AB Assessing and quantifying cyber risk accurately in real-time is essential to providing security and mission assurance in any system and network. This paper presents a modeling and dynamic analysis approach to assessing cyber risk of a network in real-time by representing dynamically its vulnerabilities, exploitations, and impact using integrated Bayesian network and Markov models. Given the set of vulnerabilities detected by a vulnerability scanner in a network, this paper addresses how its risk can be assessed by estimating in real-time the exploit likelihood and impact of vulnerability exploitation on the network, based on real-time observations and measurements over the network. The dynamic representation of the network in terms of its vulnerabilities, sensor measurements, and observations is constructed dynamically using the integrated Bayesian network and Markov models. The transition rates of outgoing and incoming links of states in hidden Markov models are used in determining exploit likelihood and impact of attacks, whereas emission rates help quantify the attack states of vulnerabilities. Simulation results show the quantification and evolving risk scores over time for individual and aggregated vulnerabilities of a network.
C1 Army Res Lab, Adelphi, MD 20773 USA.
RP Cam, H (reprint author), Army Res Lab, Adelphi, MD 20773 USA.
EM hasan.cam.civ@mail.mil
NR 12
TC 0
Z9 0
U1 4
U2 7
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-574-2
J9 PROC SPIE
PY 2015
VL 9458
AR 945809
DI 10.1117/12.2177405
PG 9
WC Engineering, Electrical & Electronic; Optics
SC Engineering; Optics
GA BC9NR
UT WOS:000356673200007
ER
PT S
AU Hutchinson, S
Erbacher, RF
AF Hutchinson, Steve
Erbacher, Robert F.
BE Ternovskiy, IV
Chin, P
TI ASN Reputation System Model
SO CYBER SENSING 2015
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Cyber Sensing
CY APR 21, 2015
CL Baltimore, MD
SP SPIE
DE Autonomous System Numbers; Reputation System; Intrusion Detection; Cyber
Security
AB Network security monitoring is currently challenged by its reliance on human analysts and the inability for tools to generate indications and warnings for previously unknown attacks. We propose a reputation system based on IP address set membership within the Autonomous System Number (ASN) system. Essentially, a metric generated based on the historic behavior, or misbehavior, of nodes within a given ASN can be used to predict future behavior and provide a mechanism to locate network activity requiring inspection. This will provide reinforcement of notifications and warnings and lead to inspection for ASNs known to be problematic even if initial inspection leads to interpretation of the event as innocuous. We developed proof of concept capabilities to generate the IP address to ASN set membership and analyze the impact of the results. These results clearly show that while some ASNs are one-offs with individual or small numbers of misbehaving IP addresses, there are definitive ASNs with a history of long term and wide spread misbehaving IP addresses. These ASNs with long histories are what we are especially interested in and will provide an additional correlation metric for the human analyst and lead to new tools to aid remediation of these IP address blocks.
C1 [Hutchinson, Steve] ICF Int Army Res Lab, Adelphi, MD 20783 USA.
[Erbacher, Robert F.] Army Res Lab, Adelphi, MD 20783 USA.
RP Hutchinson, S (reprint author), ICF Int Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM Steve.Hutchinson@mail.mil; Robert.F.Erbacher.civ@mail.mil
NR 17
TC 0
Z9 0
U1 0
U2 1
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-574-2
J9 PROC SPIE
PY 2015
VL 9458
AR 94580A
DI 10.1117/12.2177464
PG 8
WC Engineering, Electrical & Electronic; Optics
SC Engineering; Optics
GA BC9NR
UT WOS:000356673200008
ER
PT S
AU Burnette, C
Schneider, M
Agarwal, S
Deterline, D
Geyer, C
Phan, CD
Lydic, RM
Green, K
Swett, B
AF Burnette, Chris
Schneider, Matt
Agarwal, Sanjeev
Deterline, Diane
Geyer, Chris
Phan, Chung D.
Lydic, Richard M., Jr.
Green, Kevin
Swett, Bruce
BE Bishop, SS
Isaacs, JC
TI Near Real-Time, On-the-Move Multi-Sensor Integration and Computing
Framework
SO DETECTION AND SENSING OF MINES, EXPLOSIVE OBJECTS, AND OBSCURED TARGETS
XX
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Detection and Sensing of Mines, Explosive Objects, and
Obscured Targets XX
CY APR 20-23, 2015
CL Baltimore, MD
SP SPIE
DE Sensor integration framework; Vehicle computing; service architecture;
near real-time; Route Clearance Patrols (RCPs); Mine detection
AB Implanted mines and improvised devices are a persistent threat to Warfighters. Current Army countermine missions for route clearance need on-the-move standoff detection to improve the rate of advance. Vehicle-based forward looking sensors such as electro-optical and infrared (EO/IR) devices can be used to identify potential threats in near real-time (NRT) at safe standoff distance to support route clearance missions. The MOVERS (Micro-Cloud for Operational, Vehicle-Based EO-IR Reconnaissance System) is a vehicle-based multi-sensor integration and exploitation system that ingests and processes video and imagery data captured from forward-looking EO/IR and thermal sensors, and also generates target/feature alerts, using the Video Processing and Exploitation Framework (VPEF) "plug and play" video processing toolset. The MOVERS Framework provides an extensible, flexible, and scalable computing and multi-sensor integration GOTS framework that enables the capability to add more vehicles, sensors, processors or displays, and a service architecture that provides low-latency raw video and metadata streams as well as a command and control interface. Functionality in the framework is exposed through the MOVERS SDK which decouples the implementation of the service and client from the specific communication protocols.
C1 [Burnette, Chris; Schneider, Matt; Deterline, Diane] EOIR Technol, Fredericksburg, VA 22408 USA.
[Agarwal, Sanjeev; Phan, Chung D.; Lydic, Richard M., Jr.] US Army Night Vis & Elect Sensors Directorate, Ft Belvoir, VA USA.
[Geyer, Chris; Green, Kevin; Swett, Bruce] EOIR Technol, Springfield, VA 22150 USA.
RP Burnette, C (reprint author), EOIR Technol, 4729 Carr Dr, Fredericksburg, VA 22408 USA.
NR 5
TC 0
Z9 0
U1 1
U2 1
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-570-4
J9 PROC SPIE
PY 2015
VL 9454
AR 94540N
DI 10.1117/12.2177760
PG 14
WC Engineering, Electrical & Electronic; Optics
SC Engineering; Optics
GA BC9OO
UT WOS:000356708000020
ER
PT S
AU Farrell, ME
Holthoff, EL
Pellegrino, PM
AF Farrell, Mikella E.
Holthoff, Ellen L.
Pellegrino, Paul M.
BE Bishop, SS
Isaacs, JC
TI Raman Detection of improvised explosive device (IED) material fabricated
using drop-on-demand Inkjet Technology on several real world surfaces
SO DETECTION AND SENSING OF MINES, EXPLOSIVE OBJECTS, AND OBSCURED TARGETS
XX
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Detection and Sensing of Mines, Explosive Objects, and
Obscured Targets XX
CY APR 20-23, 2015
CL Baltimore, MD
SP SPIE
DE Raman; substrate; Ammonium nitrate; plastic; fabric; human hair; wood;
rubber
ID ION MOBILITY SPECTROMETRY; INDUCED BREAKDOWN SPECTROSCOPY; POLYMORPHIC
PHASE-TRANSITION; AMMONIUM-NITRATE PARTICLES; ENHANCED RAMAN; TRACE
EXPLOSIVES; MASS-SPECTROMETRY; COMPOSITION C-4; SOLID-STATE;
FINGERPRINTS
AB The requirement to detect hazardous materials (i.e., chemical, biological, and explosive) on a host of materials has led to the development of hazard detection systems. These new technologies and their capabilities could have immediate uses for the US military, national security agencies, and environmental response teams in efforts to keep people secure and safe. In particular, due to the increasing use by terrorists, the detection of common explosives and improvised explosive device (IED) materials have motivated research efforts toward detecting trace (i.e., particle level) quantities on multiple commonly encountered surfaces (e.g., textiles, metals, plastics, natural products, and even people). Non-destructive detection techniques can detect trace quantities of explosive materials; however, it can be challenging in the presence of a complex chemical background. One spectroscopic technique gaining increased attention for detection is Raman. One popular explosive precursor material is ammonium nitrate (AN). The material AN has many agricultural applications, however it can also be used in the fabrication of IEDs or homemade explosives (HMEs). In this paper, known amounts of AN will be deposited using an inkjet printer into several different common material surfaces (e.g., wood, human hair, textiles, metals, plastics). The materials are characterized with microscope images and by collecting Raman spectral data. In this report the detection and identification of AN will be demonstrated.
C1 [Farrell, Mikella E.; Holthoff, Ellen L.; Pellegrino, Paul M.] US Army Res Labs, RDRL SEE E, Adelphi, MD 21228 USA.
RP Farrell, ME (reprint author), US Army Res Labs, RDRL SEE E, 2800 Powder Mill Rd, Adelphi, MD 21228 USA.
NR 97
TC 0
Z9 0
U1 3
U2 13
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-570-4
J9 PROC SPIE
PY 2015
VL 9454
AR 94540T
DI 10.1117/12.2176553
PG 13
WC Engineering, Electrical & Electronic; Optics
SC Engineering; Optics
GA BC9OO
UT WOS:000356708000026
ER
PT S
AU Green, K
Geyer, C
Burnette, C
Agarwal, S
Swett, B
Phan, C
Deterline, D
AF Green, Kevin
Geyer, Chris
Burnette, Chris
Agarwal, Sanjeev
Swett, Bruce
Phan, Chung
Deterline, Diane
BE Bishop, SS
Isaacs, JC
TI Near Real-Time, On-The-Move Software PED using VPEF
SO DETECTION AND SENSING OF MINES, EXPLOSIVE OBJECTS, AND OBSCURED TARGETS
XX
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Detection and Sensing of Mines, Explosive Objects, and
Obscured Targets XX
CY APR 20-23, 2015
CL Baltimore, MD
SP SPIE
DE Near Real-Time; PED; Full-Motion Video; Mine Detection; Computer Vision;
Route Clearance Package; Sensor Systems; Algorithms
AB The scope of the Micro-Cloud for Operational, Vehicle-Based EO-IR Reconnaissance System (MOVERS) development effort, managed by the Night Vision and Electronic Sensors Directorate (NVESD), is to develop, integrate, and demonstrate new sensor technologies and algorithms that improve improvised device/mine detection using efficient and effective exploitation and fusion of sensor data and target cues from existing and future Route Clearance Package (RCP) sensor systems. Unfortunately, the majority of forward looking Full Motion Video (FMV) and computer vision processing, exploitation, and dissemination (PED) algorithms are often developed using proprietary, incompatible software. This makes the insertion of new algorithms difficult due to the lack of standardized processing chains. In order to overcome these limitations, EOIR developed the Government off-the-shelf (GOTS) Video Processing and Exploitation Framework (VPEF) to be able to provide standardized interfaces (e.g., input/output video formats, sensor metadata, and detected objects) for exploitation software and to rapidly integrate and test computer vision algorithms. EOIR developed a vehicle-based computing framework within the MOVERS and integrated it with VPEF. VPEF was further enhanced for automated processing, detection, and publishing of detections in near real-time, thus improving the efficiency and effectiveness of RCP sensor systems.
C1 [Green, Kevin; Geyer, Chris; Burnette, Chris; Swett, Bruce; Deterline, Diane] EOIR Technol Inc, Fredericksburg, VA 22408 USA.
[Agarwal, Sanjeev; Phan, Chung] US Army RDECOM CERDEC NVESD, Ft Belvoir, VA 22060 USA.
RP Green, K (reprint author), EOIR Technol Inc, 10300 Spotsylvania Ave,Suite 420, Fredericksburg, VA 22408 USA.
NR 5
TC 0
Z9 0
U1 0
U2 0
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-570-4
J9 PROC SPIE
PY 2015
VL 9454
AR 94540O
DI 10.1117/12.2177750
PG 12
WC Engineering, Electrical & Electronic; Optics
SC Engineering; Optics
GA BC9OO
UT WOS:000356708000021
ER
PT S
AU Heinz, DC
Brennan, ML
Steer, MB
Melber, AW
Cua, JT
AF Heinz, Daniel C.
Brennan, Michael L.
Steer, Michael B.
Melber, Adam W.
Cua, John T.
BE Bishop, SS
Isaacs, JC
TI Phase Response of High to Very High Frequency Metal/Anomaly Detector
SO DETECTION AND SENSING OF MINES, EXPLOSIVE OBJECTS, AND OBSCURED TARGETS
XX
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Detection and Sensing of Mines, Explosive Objects, and
Obscured Targets XX
CY APR 20-23, 2015
CL Baltimore, MD
SP SPIE
DE Detector; High Frequency; Very High Frequency; Metal; Anomaly; Phase
AB In this paper the phase response and reflection coefficient notch of a metal/anomaly detector design that operates in the high to very high frequency range is studied. This design uses a high-Q tuned loop antenna for metal/anomaly detection. By measuring the reflection coefficient or voltage standing wave ratio a frequency notch can be detected. Tuning to the optimal location for detector performance can be accomplished by monitoring both the depth of the notch and the phase response. It has been experimentally observed that there are three regions of interest relative to the notch and phase response of the detector. One is at the frequency where the phase response is on a near vertical line of substantial phase shift and the notch is near its deepest depth. The second and third are at slightly higher and lower frequencies, where the slope of the phase shift line is reduced and the notch is still deep, but slightly removed from the frequency of maximum depth. As would be expected, initial experimentation indicates that the region of maximum detection performance, in terms of relative change in phase response, occurs when the phase response is at the center of the near vertical phase shift response near the location of the deepest notch. However, there may be advantages to the other two regions, since the response is more stable and less prone to false alarms. Performance results for various combinations of phase response and notch depth will be shown.
C1 [Heinz, Daniel C.; Melber, Adam W.; Cua, John T.] US Army, CERDEC Intelligence & Informat Warfare Directorat, ATTN RDER IWI IT, Aberdeen Proving Ground, MD 21005 USA.
[Brennan, Michael L.] CACI Int Inc, Aberdeen Proving Ground, MD 21005 USA.
[Steer, Michael B.] N Carolina State Univ, Raleigh, NC 27606 USA.
RP Heinz, DC (reprint author), US Army, CERDEC Intelligence & Informat Warfare Directorat, ATTN RDER IWI IT, Bldg 6003, Aberdeen Proving Ground, MD 21005 USA.
NR 2
TC 0
Z9 0
U1 0
U2 0
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-570-4
J9 PROC SPIE
PY 2015
VL 9454
AR 94540H
DI 10.1117/12.2182083
PG 7
WC Engineering, Electrical & Electronic; Optics
SC Engineering; Optics
GA BC9OO
UT WOS:000356708000014
ER
PT S
AU Ling, B
Agarwal, S
Olivera, S
Vasilkoski, Z
Phan, C
Geyer, C
AF Ling, Bo
Agarwal, Sanjeev
Olivera, Santiago
Vasilkoski, Zlatko
Phan, Chung
Geyer, Chris
BE Bishop, SS
Isaacs, JC
TI Real-Time Buried Threat Detection and Cueing Capability in VPEF
Environment
SO DETECTION AND SENSING OF MINES, EXPLOSIVE OBJECTS, AND OBSCURED TARGETS
XX
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Detection and Sensing of Mines, Explosive Objects, and
Obscured Targets XX
CY APR 20-23, 2015
CL Baltimore, MD
SP SPIE
DE buried threat detection; false alarm mitigation; target track; GStreamer
plugin; VPEF
AB In this paper, we present a vehicular buried threat detection approach developed over the past several years, and its latest implementation and integration in VPEF environment. Buried threats have varying signatures under different operation environment. To reliably detect the true targets and minimizing the number of false alarms, a suite of false alarm mitigators (FAMs) have been developed to process the potential targets identified by the baseline module. A vehicle track can be formed over a number of frames and targets are further analyzed both spatially and temporally. Algorithms have been implemented in C/C++ as GStreamer plugins and are suitable for vehicle mounted, on-the-move realtime exploitation.
C1 [Ling, Bo; Olivera, Santiago; Vasilkoski, Zlatko] Migma Syst Inc, Walpole, MA 02081 USA.
[Agarwal, Sanjeev; Phan, Chung] US Army RDECOM CERDEC NVESD, Ft Belvoir, VA 22060 USA.
[Geyer, Chris] EOIR Technol Inc, Fredricksburg, VA 22408 USA.
RP Ling, B (reprint author), Migma Syst Inc, 1600 Providence Highway, Walpole, MA 02081 USA.
NR 12
TC 0
Z9 0
U1 0
U2 0
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-570-4
J9 PROC SPIE
PY 2015
VL 9454
AR 94540P
DI 10.1117/12.2177743
PG 14
WC Engineering, Electrical & Electronic; Optics
SC Engineering; Optics
GA BC9OO
UT WOS:000356708000022
ER
PT S
AU Luke, RH
Bishop, SS
Chan, AM
Gugino, PM
Donzelli, TP
Soumekh, M
AF Luke, Robert H.
Bishop, Steven S.
Chan, Aaron M.
Gugino, Peter M.
Donzelli, Thomas P.
Soumekh, Mehrdad
BE Bishop, SS
Isaacs, JC
TI A Synthetic Aperture Acoustic Prototype System
SO DETECTION AND SENSING OF MINES, EXPLOSIVE OBJECTS, AND OBSCURED TARGETS
XX
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Detection and Sensing of Mines, Explosive Objects, and
Obscured Targets XX
CY APR 20-23, 2015
CL Baltimore, MD
SP SPIE
DE acoustic imaging; aero-acoustic sonar; side scanning synthetic aperture
acoustic; SAA
AB A novel quasi-monostatic system operating in a side-scan synthetic aperture acoustic (SAA) imaging mode is presented. This research project's objectives are to explore the military utility of outdoor continuous sound imaging of roadside foliage and target detection. The acoustic imaging method has several military relevant advantages such as being immune to RF jamming, superior spatial resolution as compared to 0.8-2.4 GHz ground penetrating radar (GPR), capable of standoff side and forward-looking scanning, and relatively low cost, weight and size when compared to GPR technologies. The prototype system's broadband 2-17 kHz LFM chirp transceiver is mounted on a manned all-terrain vehicle. Targets are positioned within the acoustic main beam at slant ranges of two to seven meters and on surfaces such as dirt, grass, gravel and weathered asphalt and with an intervening metallic chain link fence. Acoustic image reconstructions and signature plots result in means for literal interpretation and quantifiable analyses.
C1 [Luke, Robert H.; Bishop, Steven S.; Chan, Aaron M.; Gugino, Peter M.; Donzelli, Thomas P.] US Army, RDECOM CERDEC NVESD, Ft Belvoir, VA 22060 USA.
[Soumekh, Mehrdad] Soumekh Consultant, Bethesda, MD USA.
RP Luke, RH (reprint author), US Army, RDECOM CERDEC NVESD, Ft Belvoir, VA 22060 USA.
EM Robert.h.luke2.civ@mail.mil
NR 4
TC 0
Z9 0
U1 2
U2 3
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-570-4
J9 PROC SPIE
PY 2015
VL 9454
AR 94540Y
DI 10.1117/12.2177457
PG 8
WC Engineering, Electrical & Electronic; Optics
SC Engineering; Optics
GA BC9OO
UT WOS:000356708000031
ER
PT S
AU Shaw, D
Ho, KC
Stone, K
Keller, JM
Popescu, M
Anderson, DT
Luke, RH
Burns, B
AF Shaw, Darren
Ho, K. C.
Stone, Kevin
Keller, James M.
Popescu, Mihail
Anderson, Derek T.
Luke, Robert H.
Burns, Brian
BE Bishop, SS
Isaacs, JC
TI Explosive Hazard Detection Using MIMO Forward-Looking Ground Penetrating
Radar
SO DETECTION AND SENSING OF MINES, EXPLOSIVE OBJECTS, AND OBSCURED TARGETS
XX
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Detection and Sensing of Mines, Explosive Objects, and
Obscured Targets XX
CY APR 20-23, 2015
CL Baltimore, MD
SP SPIE
DE Forward-looking explosive hazards detection; ground-penetrating radar;
Support Vector Machine; spectral features; log-Gabor
ID LOG-GABOR FILTERS; LANDMINE DETECTION
AB This paper proposes a machine learning algorithm for subsurface object detection on multiple-input-multiple-output (MIMO) forward-looking ground-penetrating radar (FLGPR). By detecting hazards using FLGPR, standoff distances of up to tens of meters can be acquired, but this is at the degradation of performance due to high false alarm rates. The proposed system utilizes an anomaly detection prescreener to identify potential object locations. Alarm locations have multiple one-dimensional (ML) spectral features, two-dimensional (2D) spectral features, and log-Gabor statistic features extracted. The ability of these features to reduce the number of false alarms and increase the probability of detection is evaluated for both co-polarizations present in the Akela MIMO array. Classification is performed by a Support Vector Machine (SVM) with lane-based cross-validation for training and testing. Class imbalance and optimized SVM kernel parameters are considered during classifier training.
C1 [Shaw, Darren; Ho, K. C.; Stone, Kevin; Keller, James M.; Popescu, Mihail] Univ Missouri, ECE Dept, Columbia, MO 65211 USA.
[Anderson, Derek T.] Mississippi State Univ, ECE Dept, Starkville, MS 39762 USA.
[Luke, Robert H.; Burns, Brian] US Army, RDECOM CERDEC Night Vis & Elect Sensors Directora, Ft Belvoir, VA 22060 USA.
RP Shaw, D (reprint author), Univ Missouri, ECE Dept, Columbia, MO 65211 USA.
NR 23
TC 1
Z9 1
U1 10
U2 14
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-570-4
J9 PROC SPIE
PY 2015
VL 9454
AR 94540Z
DI 10.1117/12.2177468
PG 14
WC Engineering, Electrical & Electronic; Optics
SC Engineering; Optics
GA BC9OO
UT WOS:000356708000032
ER
PT S
AU Jahnke, JP
Mackie, DM
Benyamin, M
Ganguli, R
Sumner, JJ
AF Jahnke, Justin P.
Mackie, David M.
Benyamin, Marcus
Ganguli, Rahul
Sumner, James J.
BE Dhar, NK
Dutta, AK
TI Performance study of sugar-yeast-ethanol bio-hybrid fuel cells
SO ENERGY HARVESTING AND STORAGE: MATERIALS, DEVICES, AND APPLICATIONS VI
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Energy Harvesting and Storage - Materials, Devices, and
Applications VI
CY APR 21, 2015
CL Baltimore, MD
SP SPIE
DE fuel cell; DAFC; PEM; yeast; waste-to-energy; renewable energy; biomass;
bio-hybrid
AB Renewable alternatives to fossil hydrocarbons for energy generation are of general interest for a variety of political, economic, environmental, and practical reasons. In particular, energy from biomass has many advantages, including safety, sustainability, and the ability to be scavenged from native ecosystems or from waste streams. Microbial fuel cells (MFCs) can take advantage of microorganism metabolism to efficiently use sugar and other biomolecules as fuel, but are limited by low power densities. In contrast, direct alcohol fuel cells (DAFCs) take advantage of proton exchange membranes (PEMs) to generate electricity from alcohols at much higher power densities. Here, we investigate a novel bio-hybrid fuel cell design prepared using commercial off-the-shelf DAFCs. In the bio-hybrid fuel cells, biomass such as sugar is fermented by yeast to ethanol, which can be used to fuel a DAFC. A separation membrane between the fermentation and the DAFC is used to purify the fermentate while avoiding any parasitic power losses. However, shifting the DAFCs from pure alcohol-water solutions to filtered fermented media introduces complications related to how the starting materials, fermentation byproducts, and DAFC waste products affect both the fermentation and the long-term DAFC performance. This study examines the impact of separation membrane pore size, fermentation/fuel cell byproducts, alcohol and salt concentrations, and load resistance on fuel cell performance. Under optimized conditions, the performance obtained is comparable to that of a similar DAFC run with a pure alcohol-water mixture. Additionally, the modified DAFC can provide useable amounts of power for weeks.
C1 [Jahnke, Justin P.; Mackie, David M.; Benyamin, Marcus; Sumner, James J.] US Army Res Lab, Adelphi, MD 20783 USA.
[Ganguli, Rahul] Teledyne Sci & Imaging LLC, Thousand Oaks, CA 91360 USA.
RP Jahnke, JP (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM justin.jahnke2.ctr@mail.mil
NR 13
TC 0
Z9 0
U1 2
U2 7
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-609-1
J9 PROC SPIE
PY 2015
VL 9493
AR 949303
DI 10.1117/12.2176465
PG 8
WC Energy & Fuels; Engineering, Electrical & Electronic; Optics; Physics,
Applied
SC Energy & Fuels; Engineering; Optics; Physics
GA BC9LM
UT WOS:000356606000002
ER
PT S
AU Prasad, N
Nemir, D
Beck, J
Maddux, J
Taylor, P
AF Prasad, Narasimha
Nemir, David
Beck, Jan
Maddux, Jay
Taylor, Patrick
BE Dhar, NK
Dutta, AK
TI Inhomogeneous Thermoelectric Materials: Improving Overall zT by
Localized Property Variations
SO ENERGY HARVESTING AND STORAGE: MATERIALS, DEVICES, AND APPLICATIONS VI
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Energy Harvesting and Storage - Materials, Devices, and
Applications VI
CY APR 21, 2015
CL Baltimore, MD
SP SPIE
DE Thermoelectric measurements; Seebeck coefficient; Peltier effect;
thermal conductivity; isothermal
ID PERFORMANCE; ALLOYS
AB The search for improved thermoelectric materials is driven in part by the desire to convert otherwise wasted low-temperature heat into useful electricity. In this work, we demonstrate a new path towards materials having higher overall zT, and consequently improved capacity to obtain more electrical power from a given content of heat. We produced alloys of (Bi,Sb)(2)Te-3 using a special gas atomization process that is capable of producing source powder material having nanometer-scale grain size. When impulse-compacted by shockwave consolidation, the obtained dense solid will retain its nanostructure because insufficient time and temperature are available for the kinetics of any appreciable grain growth to proceed. However, if there is initial non-uniformity in the properties of the source powder, or if there is stress non-symmetries during shockwave consolidation, then the obtained consolidated material may have locally inhomogeneous properties distributed throughout the material. Thermoelectric property measurements from selected regions within the consolidated sample indicate a wide distribution of properties. For example, the thermal conductivity at room temperature ranged from as low as 1.30 Watts/m-K in one region to higher than 3.00 Watts/m-K in a neighboring region. The electrical resistivity showed similar variation from as low as 0.5 m Omega-cm to as high as 1.5 m Omega-cm. Individually, those regions exhibited thermoelectric material figure-of-merit, zT values ranging between 0.3 and 0.4. However, when combined into a dense nanocomposite, the overall ensemble zT approaches 0.7 which is nearly a factor of 2 higher.
C1 [Prasad, Narasimha] NASA, Langley Res Ctr, Hampton, VA 23681 USA.
[Nemir, David; Beck, Jan] TXL Grp Inc, El Paso, TX 79903 USA.
[Maddux, Jay; Taylor, Patrick] US Army Res Lab, Adelphi, MD 20783 USA.
RP Prasad, N (reprint author), NASA, Langley Res Ctr, 5 N Dryden St,MS 468, Hampton, VA 23681 USA.
EM narasimha.s.prasad@nasa.gov
NR 12
TC 1
Z9 1
U1 0
U2 3
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-609-1
J9 PROC SPIE
PY 2015
VL 9493
AR 949305
DI 10.1117/12.2181143
PG 7
WC Energy & Fuels; Engineering, Electrical & Electronic; Optics; Physics,
Applied
SC Energy & Fuels; Engineering; Optics; Physics
GA BC9LM
UT WOS:000356606000004
ER
PT S
AU Burks, SD
Haefner, DP
Burks, TJ
AF Burks, Stephen D.
Haefner, David P.
Burks, Thomas J.
BE Holst, GC
Krapels, KA
TI Signal intensity transfer function determination on thermal systems with
stray light or scattering present
SO INFRARED IMAGING SYSTEMS: DESIGN, ANALYSIS, MODELING, AND TESTING XXVI
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Infrared Imaging Systems - Design, Analysis, Modeling, and
Testing XXVI
CY APR 21-23, 2015
CL Baltimore, MD
SP SPIE
DE SITF; Signal Intensity Transfer Function; 3D Noise; LWIR; MWIR;
Undersampled Imaging Systems
AB Accurate Signal Intensity Transfer Functions (SITF) measurements are necessary to determine the calibration factor in the 3D noise calculation of an electro-optical imaging system. The typical means for measuring a sensor's SITF is to place the sensor in a flooded field environment at a distance that is relatively close to the aperture of the emitter. Unfortunately, this arrangement has the potential to allow for additional contributions to the SITF in the form of scattering or stray light if the optics are not designed properly in the system under test. Engineers at the US Army Night Vision and Electronic Sensors Directorate are working to determine a means of evaluating the contribution due to scatting or stray light.
C1 [Burks, Stephen D.; Haefner, David P.] US Army, RDECOM CERDEC, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA.
[Burks, Thomas J.] Matthew Maury Elementary Sch, Alexandria, VA 22301 USA.
RP Burks, SD (reprint author), US Army, RDECOM CERDEC, Night Vis & Elect Sensors Directorate, 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA.
NR 4
TC 0
Z9 0
U1 2
U2 3
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-568-1
J9 PROC SPIE
PY 2015
VL 9452
AR 945206
DI 10.1117/12.2178150
PG 10
WC Engineering, Electrical & Electronic; Optics; Imaging Science &
Photographic Technology
SC Engineering; Optics; Imaging Science & Photographic Technology
GA BC9NS
UT WOS:000356673800005
ER
PT S
AU Burks, SD
Doe, JM
Teaney, BP
AF Burks, Stephen D.
Doe, Joshua M.
Teaney, Brian P.
BE Holst, GC
Krapels, KA
TI Validating Machine Vision MRT performance against trained observer
performance for linear shift invariant sensors
SO INFRARED IMAGING SYSTEMS: DESIGN, ANALYSIS, MODELING, AND TESTING XXVI
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Infrared Imaging Systems - Design, Analysis, Modeling, and
Testing XXVI
CY APR 21-23, 2015
CL Baltimore, MD
SP SPIE
DE Minimum Resolvable Temperature Difference; MRT; MRTD; LWIR; MWIR;
Undersampled Imaging Systems
AB Researchers at the US Army Night Vision and Electronic Sensors Directorate have added the functionality of Machine Vision MRT (MV-MRT) to the NVLabCap software package. While the original calculations of MV-MRT were compared to human observers performance using digital imagery in a previous effort,1 the technical approach was not tested on 8-bit imagery using a variety of sensors in a variety of gain and level settings. Now that it is more simple to determine the MV-MRT for a sensor in multiple gain settings, it is prudent to compare the results of MV-MRT in multiple gain settings to the performance of human observers for thermal imaging systems that are linear and shift invariant. Here, a comparison of the results for a LWIR system to trained human observers is presented.
C1 [Burks, Stephen D.; Doe, Joshua M.; Teaney, Brian P.] US Army, RDECOM CERDEC, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA.
RP Burks, SD (reprint author), US Army, RDECOM CERDEC, Night Vis & Elect Sensors Directorate, 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA.
NR 9
TC 0
Z9 0
U1 0
U2 1
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-568-1
J9 PROC SPIE
PY 2015
VL 9452
AR 945204
DI 10.1117/12.2178149
PG 8
WC Engineering, Electrical & Electronic; Optics; Imaging Science &
Photographic Technology
SC Engineering; Optics; Imaging Science & Photographic Technology
GA BC9NS
UT WOS:000356673800003
ER
PT S
AU Deaver, DM
Moyer, S
AF Deaver, Dawne M.
Moyer, Steve
BE Holst, GC
Krapels, KA
TI Statistical analysis for target acquisition sensor modeling experiments
SO INFRARED IMAGING SYSTEMS: DESIGN, ANALYSIS, MODELING, AND TESTING XXVI
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Infrared Imaging Systems - Design, Analysis, Modeling, and
Testing XXVI
CY APR 21-23, 2015
CL Baltimore, MD
SP SPIE
DE sensor modeling; visual perception experiments; confidence intervals;
sample size
AB The U.S. Army RDECOM CERDEC NVESD Modeling and Simulation Division is charged with the development and advancement of military target acquisition models to estimate expected soldier performance when using all types of imaging sensors. Two elements of sensor modeling are (1) laboratory-based psychophysical experiments used to measure task performance and calibrate the various models and (2) field-based experiments used to verify the model estimates for specific sensors. In both types of experiments, it is common practice to control or measure environmental, sensor, and target physical parameters in order to minimize uncertainty of the physics based modeling. Predicting the minimum number of test subjects required to calibrate or validate the model should be, but is not always, done during test planning. The objective of this analysis is to develop guidelines for test planners which recommend the number and types of test samples required to yield a statistically significant result.
C1 [Deaver, Dawne M.; Moyer, Steve] US Army, Res Dev & Engn Command, Commun Elect Res Dev & Engn Ctr, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA.
RP Deaver, DM (reprint author), US Army, Res Dev & Engn Command, Commun Elect Res Dev & Engn Ctr, Night Vis & Elect Sensors Directorate, 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA.
NR 7
TC 0
Z9 0
U1 0
U2 0
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-568-1
J9 PROC SPIE
PY 2015
VL 9452
AR 945208
DI 10.1117/12.2177741
PG 14
WC Engineering, Electrical & Electronic; Optics; Imaging Science &
Photographic Technology
SC Engineering; Optics; Imaging Science & Photographic Technology
GA BC9NS
UT WOS:000356673800007
ER
PT S
AU Du Bosq, T
Repasi, E
AF Du Bosq, Todd
Repasi, Endre
BE Holst, GC
Krapels, KA
TI Detector Integration Time Dependent Atmospheric Turbulence Imaging
Simulation
SO INFRARED IMAGING SYSTEMS: DESIGN, ANALYSIS, MODELING, AND TESTING XXVI
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Infrared Imaging Systems - Design, Analysis, Modeling, and
Testing XXVI
CY APR 21-23, 2015
CL Baltimore, MD
SP SPIE
DE Imaging Simulation; Atmospheric Turbulence; Integration Time
AB Atmospheric turbulence is a well-known phenomenon that often degrades image quality due to intensity fluctuations, distortion, and blur in electro-optic and thermal imaging systems. To properly assess the performance of an imaging system over the typical turbulence trade space, a time consuming and costly field study is often required. A fast and realistic turbulence simulation will allow the performance assessment of an imaging system under various turbulence conditions to be done as well as provide input data for the evaluation of turbulence mitigation algorithms in a cost efficient manner.
The simulation is based on an empirical model with parameters derived from the first and second-order statistics of imaging distortions measured from field collected data. The dataset consists of image sequences recorded with a variable frame rate visible camera from strong to weak turbulence conditions. The simulation uses pristine, single images containing no turbulence effects as an input and produces image sequences degraded by the specified turbulence. Target range, optics diameter, wavelength, detector integration time, and the wind velocity component perpendicular to the propagation path all contribute to the severity of the atmospheric turbulence distortions and are included in the simulation. The addition of the detector integration time expands the functionality of the simulation tool to include imagers with lower frames rates. Examples are presented demonstrating the utility of the turbulence simulation.
C1 [Du Bosq, Todd] US Army, RDECOM CERDEC NVESD, Ft Belvoir, VA 22060 USA.
[Repasi, Endre] Fraunhofer Inst Optron Syst Technol & Image Explo, D-76275 Ettlingen, Germany.
RP Du Bosq, T (reprint author), US Army, RDECOM CERDEC NVESD, 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA.
EM info@nvl.army.mil
NR 13
TC 1
Z9 1
U1 0
U2 0
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-568-1
J9 PROC SPIE
PY 2015
VL 9452
AR 94520B
DI 10.1117/12.2176985
PG 13
WC Engineering, Electrical & Electronic; Optics; Imaging Science &
Photographic Technology
SC Engineering; Optics; Imaging Science & Photographic Technology
GA BC9NS
UT WOS:000356673800010
ER
PT S
AU Espinola, RL
Leonard, KR
Byrd, KA
Potvin, G
AF Espinola, Richard L.
Leonard, Kevin R.
Byrd, Kenneth A.
Potvin, Guy
BE Holst, GC
Krapels, KA
TI Atmospheric turbulence and sensor system effects on biometric algorithm
performance
SO INFRARED IMAGING SYSTEMS: DESIGN, ANALYSIS, MODELING, AND TESTING XXVI
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Infrared Imaging Systems - Design, Analysis, Modeling, and
Testing XXVI
CY APR 21-23, 2015
CL Baltimore, MD
SP SPIE
DE atmospheric turbulence; simulation; biometrics; facial recognition
AB Biometric technologies composed of electro-optical/infrared (EO/IR) sensor systems and advanced matching algorithms are being used in various force protection/security and tactical surveillance applications. To date, most of these sensor systems have been widely used in controlled conditions with varying success (e.g., short range, uniform illumination, cooperative subjects). However the limiting conditions of such systems have yet to be fully studied for long range applications and degraded imaging environments. Biometric technologies used for long range applications will invariably suffer from the effects of atmospheric turbulence degradation. Atmospheric turbulence causes blur, distortion and intensity fluctuations that can severely degrade image quality of electro-optic and thermal imaging systems and, for the case of biometrics technology, translate to poor matching algorithm performance. In this paper, we evaluate the effects of atmospheric turbulence and sensor resolution on biometric matching algorithm performance. We use a subset of the Facial Recognition Technology (FERET) database and a commercial algorithm to analyze facial recognition performance on turbulence degraded facial images. The goal of this work is to understand the feasibility of long-range facial recognition in degraded imaging conditions, and the utility of camera parameter trade studies to enable the design of the next generation biometrics sensor systems.
C1 [Espinola, Richard L.; Leonard, Kevin R.; Byrd, Kenneth A.] US Army, RDECOM CERDEC NVESD, Ft Belvoir, VA 22060 USA.
[Potvin, Guy] DRDC Valcartier Res Ctr, Quebec City, PQ, Canada.
RP Espinola, RL (reprint author), US Army, RDECOM CERDEC NVESD, Ft Belvoir, VA 22060 USA.
NR 16
TC 0
Z9 0
U1 0
U2 0
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-568-1
J9 PROC SPIE
PY 2015
VL 9452
AR 94520D
DI 10.1117/12.2177800
PG 10
WC Engineering, Electrical & Electronic; Optics; Imaging Science &
Photographic Technology
SC Engineering; Optics; Imaging Science & Photographic Technology
GA BC9NS
UT WOS:000356673800012
ER
PT S
AU Friedman, M
AF Friedman, Melvin
BE Holst, GC
Krapels, KA
TI Investigating the Validity of the Networked Imaging Sensor Model
SO INFRARED IMAGING SYSTEMS: DESIGN, ANALYSIS, MODELING, AND TESTING XXVI
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Infrared Imaging Systems - Design, Analysis, Modeling, and
Testing XXVI
CY APR 21-23, 2015
CL Baltimore, MD
SP SPIE
AB The Networked Imaging Sensor (NIS) model takes as input target acquisition probability as a function of time for individuals or individual imaging sensors, and outputs target acquisition probability for a collection of imaging sensors and individuals. System target acquisition takes place the moment the first sensor or individual acquires the target. The derivation of the NIS model implies it is applicable to multiple moving sensors and targets. The principal assumption of the NIS model is independence of events that give rise to input target acquisition probabilities. For investigating the validity of the NIS model, we consider a collection of single images where neither the sensor nor target is moving. This paper investigates the ability of the NIS model to predict system target acquisition performance when multiple observers view first and second Gen thermal imagery, field-of-view imagery that has either zero or one stationary target in a laboratory environment when observers have a maximum of 12, 17 or unlimited seconds to acquire the target. Modeled and measured target acquisition performance are in good agreement.
C1 US Army, RDECOM, Commun Elect Res Dev & Engn Ctr, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA.
RP Friedman, M (reprint author), US Army, RDECOM, Commun Elect Res Dev & Engn Ctr, Night Vis & Elect Sensors Directorate, Ft Belvoir, Ft Belvoir, VA 22060 USA.
EM info@nvl.army.mil
NR 14
TC 0
Z9 0
U1 0
U2 0
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-568-1
J9 PROC SPIE
PY 2015
VL 9452
AR 94520R
DI 10.1117/12.2178418
PG 52
WC Engineering, Electrical & Electronic; Optics; Imaging Science &
Photographic Technology
SC Engineering; Optics; Imaging Science & Photographic Technology
GA BC9NS
UT WOS:000356673800025
ER
PT S
AU Furxhi, O
Driggers, RG
Preece, B
Krapels, K
AF Furxhi, Orges
Driggers, Ronald G.
Preece, Bradley
Krapels, Keith
BE Holst, GC
Krapels, KA
TI Modeling Analysis Metrics for Panoramic Sensors
SO INFRARED IMAGING SYSTEMS: DESIGN, ANALYSIS, MODELING, AND TESTING XXVI
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Infrared Imaging Systems - Design, Analysis, Modeling, and
Testing XXVI
CY APR 21-23, 2015
CL Baltimore, MD
SP SPIE
DE panoramic; infrared; military vehicles; military requirements
AB Panoramic infrared imaging is relatively new and has many applications to include tower mounted security systems, shipboard protection, and platform situational awareness. In this paper, we review metrics and methods that can be used for analysis of requirements for an infrared panoramic imaging system for military vehicles. We begin with a broad view of general military requirements organized into three categories, survivability, mobility, and lethality. A few requirements for the sensor modes of operation across all categories are selected so that panoramic system design can address as many needs as possible, but with affordability applied to system design. Metrics and associated methods that can translate military operational requirements into panoramic imager requirements are discussed in detail in this paper.
C1 [Furxhi, Orges; Driggers, Ronald G.] St Johns Opt Syst, Lake Mary, FL 32746 USA.
[Preece, Bradley; Krapels, Keith] US Army, RDECOM CERDEC Night Vis & Elect Sensors Direct, Modeling & Simulat Div, Ft Belvoir, VA 22060 USA.
RP Furxhi, O (reprint author), St Johns Opt Syst, 1130 Business Ctr Dr, Lake Mary, FL 32746 USA.
EM orges.furxhi@stjohnsopticalsystems.com
NR 8
TC 0
Z9 0
U1 1
U2 1
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-568-1
J9 PROC SPIE
PY 2015
VL 9452
AR 945209
DI 10.1117/12.2179740
PG 12
WC Engineering, Electrical & Electronic; Optics; Imaging Science &
Photographic Technology
SC Engineering; Optics; Imaging Science & Photographic Technology
GA BC9NS
UT WOS:000356673800008
ER
PT S
AU Haefner, DP
Teaney, BP
Burks, SD
AF Haefner, David P.
Teaney, Brian P.
Burks, Stephen D.
BE Holst, GC
Krapels, KA
TI Blackbox Imager Characterization, from Measurements to Modeling Range
Performance
SO INFRARED IMAGING SYSTEMS: DESIGN, ANALYSIS, MODELING, AND TESTING XXVI
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Infrared Imaging Systems - Design, Analysis, Modeling, and
Testing XXVI
CY APR 21-23, 2015
CL Baltimore, MD
SP SPIE
DE System characterization; Modeling system performance; MTF measurement;
Photon Transfer
AB Typically, the modeling of linear and shift-invariant (LSI) imaging systems requires a complete description of each sub-component in order to estimate the final system transfer function. To validate the modeled behavior, measurements are performed on each component. When dealing with packaged systems, there are many situations where some, if not all, data is unknown. For these cases, the system is considered a blackbox, and system level measurements are used to estimate the transfer characteristics in order to model performance. This correspondence outlines the blackbox measured system component in the Night Vision Integrated Performance Model (NV-IPM). We describe how estimates of performance can be achieved with complete or incomplete measurements and how assumptions affect the final range. The blackbox measured component is the final output of a measurement characterization and is used to validate performance of delivered and prototype systems.
C1 [Haefner, David P.; Teaney, Brian P.; Burks, Stephen D.] US Army, RDECOM CERDEC, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA.
RP Haefner, DP (reprint author), US Army, RDECOM CERDEC, Night Vis & Elect Sensors Directorate, 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA.
NR 10
TC 0
Z9 0
U1 0
U2 0
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-568-1
J9 PROC SPIE
PY 2015
VL 9452
AR 945202
DI 10.1117/12.2180386
PG 8
WC Engineering, Electrical & Electronic; Optics; Imaging Science &
Photographic Technology
SC Engineering; Optics; Imaging Science & Photographic Technology
GA BC9NS
UT WOS:000356673800001
ER
PT S
AU Hodgkin, VA
AF Hodgkin, Van A.
BE Holst, GC
Krapels, KA
TI Contrast Performance Modeling of Broadband Reflective Imaging Systems
with Hypothetical Tunable Filter Fore-Optics
SO INFRARED IMAGING SYSTEMS: DESIGN, ANALYSIS, MODELING, AND TESTING XXVI
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Infrared Imaging Systems - Design, Analysis, Modeling, and
Testing XXVI
CY APR 21-23, 2015
CL Baltimore, MD
SP SPIE
DE Reflective imaging; image contrast; spectral contrast; hyperspectral;
target discrimination
AB Most mass-produced, commercially available and fielded military reflective imaging systems operate across broad swaths of the visible, near infrared (NIR), and shortwave infrared (SWIR) wavebands without any spectral selectivity within those wavebands. In applications that employ these systems, it is not uncommon to be imaging a scene in which the image contrasts between the objects of interest, i.e., the targets, and the objects of little or no interest, i.e., the backgrounds, are sufficiently low to make target discrimination difficult or uncertain. This can occur even when the spectral distribution of the target and background reflectivity across the given waveband differ significantly from each other, because the fundamental components of broadband image contrast are the spectral integrals of the target and background signatures. Spectral integration by the detectors tends to smooth out any differences. Hyperspectral imaging is one approach to preserving, and thus highlighting, spectral differences across the scene, even when the waveband integrated signatures would be about the same, but it is an expensive, complex, noncompact, and untimely solution. This paper documents a study of how the capability to selectively customize the spectral width and center wavelength with a hypothetical tunable fore-optic filter would allow a broadband reflective imaging sensor to optimize image contrast as a function of scene content and ambient illumination.
C1 US Army RDECOM CERDEC NVESD, Ft Belvoir, VA 22060 USA.
RP Hodgkin, VA (reprint author), US Army RDECOM CERDEC NVESD, 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA.
NR 4
TC 0
Z9 0
U1 0
U2 0
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-568-1
J9 PROC SPIE
PY 2015
VL 9452
AR UNSP 945216
DI 10.1117/12.2176956
PG 11
WC Engineering, Electrical & Electronic; Optics; Imaging Science &
Photographic Technology
SC Engineering; Optics; Imaging Science & Photographic Technology
GA BC9NS
UT WOS:000356673800037
ER
PT S
AU Howell, CL
Choi, HS
Reynolds, JP
AF Howell, Christopher L.
Choi, Hee-Sue
Reynolds, Joseph P.
BE Holst, GC
Krapels, KA
TI Face Acquisition Camera Design Using the NV-IPM Image Generation Tool
SO INFRARED IMAGING SYSTEMS: DESIGN, ANALYSIS, MODELING, AND TESTING XXVI
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Infrared Imaging Systems - Design, Analysis, Modeling, and
Testing XXVI
CY APR 21-23, 2015
CL Baltimore, MD
SP SPIE
DE NV-IPM; Image Generation; Sensor Performance; Facial Recognition
ID RANGE
AB In this paper, we demonstrate the utility of the Night Vision Integrated Performance Model (NV-IPM) image generation tool by using it to create a database of face images with controlled degradations. Available face recognition algorithms can then be used to directly evaluate camera designs using these degraded images. By controlling camera effects such as blur, noise, and sampling, we can analyze algorithm performance and establish a more complete performance standard for face acquisition cameras. The ability to accurately simulate imagery and directly test with algorithms not only improves the system design process but greatly reduces development cost.
C1 [Howell, Christopher L.; Choi, Hee-Sue; Reynolds, Joseph P.] US Army, RDECOM, CERDEC, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA.
RP Howell, CL (reprint author), US Army, RDECOM, CERDEC, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA.
NR 9
TC 0
Z9 0
U1 0
U2 0
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-568-1
J9 PROC SPIE
PY 2015
VL 9452
AR UNSP 94520T
DI 10.1117/12.2179619
PG 10
WC Engineering, Electrical & Electronic; Optics; Imaging Science &
Photographic Technology
SC Engineering; Optics; Imaging Science & Photographic Technology
GA BC9NS
UT WOS:000356673800027
ER
PT S
AU Kaur, B
Olson, JT
Hixson, JG
Richardson, PI
Flug, EA
AF Kaur, Balvinder
Olson, Jeff T.
Hixson, Jonathan G.
Richardson, Philip I.
Flug, Eric A.
BE Holst, GC
Krapels, KA
TI Characterizing a High Resolution Color Display Performance using a
Prichard Photometer
SO INFRARED IMAGING SYSTEMS: DESIGN, ANALYSIS, MODELING, AND TESTING XXVI
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Infrared Imaging Systems - Design, Analysis, Modeling, and
Testing XXVI
CY APR 21-23, 2015
CL Baltimore, MD
SP SPIE
DE Cathode Ray Tube (CRT); Liquid Crystal Display (LCD); Photometer; High
Resolution Monitors; Minimum Resolvable Temperature (MRT); Contrast
Threshold Function (CTF)
ID LIQUID-CRYSTAL DISPLAY; IMAGE QUALITY; LCD; TFT; CRT; GAMMA
AB Measuring the performance of a cathode ray tube (CRT) or liquid crystal display (LCD) is necessary to enable end-to-end system modeling and characterization of currently used high performance analog imaging systems, such as 2nd Generation FLIR systems. If the display is color, the performance measurements are made more difficult because of the underlying structure of the color pixel as compared to a monochrome pixel. Out of the various characteristics of interest, we focus on determining the gamma value of a display. Gamma quantifies the non-linear response between the input gray scale and the displayed luminance. If the displayed image can be corrected for the display's gamma, an accurate scene can be presented or characterized for laboratory measurements such as MRT (Minimum Resolvable Temperature) and CTF (Contrast Threshold Function). In this paper, we present a method to determine the gamma to characterize a color display using the Prichard 1980A photometer. Gamma corrections were applied to the test images for validating the accuracy of the computed gamma value. The method presented here is a simple one easily implemented employing a Prichard photometer.
C1 [Kaur, Balvinder; Olson, Jeff T.; Hixson, Jonathan G.; Richardson, Philip I.; Flug, Eric A.] US Army, RDECOM CERDEC, NVESD, Ft Belvoir, VA 22060 USA.
RP Kaur, B (reprint author), US Army, RDECOM CERDEC, NVESD, Ft Belvoir, VA 22060 USA.
NR 26
TC 0
Z9 0
U1 0
U2 2
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-568-1
J9 PROC SPIE
PY 2015
VL 9452
AR 945203
DI 10.1117/12.2177888
PG 12
WC Engineering, Electrical & Electronic; Optics; Imaging Science &
Photographic Technology
SC Engineering; Optics; Imaging Science & Photographic Technology
GA BC9NS
UT WOS:000356673800002
ER
PT S
AU Moyer, S
Uhl, ER
AF Moyer, Steve
Uhl, Elizabeth R.
BE Holst, GC
Krapels, KA
TI Block randomization versus complete randomization of human perception
stimuli: Is there a difference?
SO INFRARED IMAGING SYSTEMS: DESIGN, ANALYSIS, MODELING, AND TESTING XXVI
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Infrared Imaging Systems - Design, Analysis, Modeling, and
Testing XXVI
CY APR 21-23, 2015
CL Baltimore, MD
SP SPIE
AB For more than 50 years, the U.S. Army RDECOM CERDEC Night Vision and Electronic Sensors Directorate (NVESD) has been studying and modeling the human visual discrimination process as it pertains to military imaging systems. In order to develop sensor performance models, human observers are trained to expert levels in the identification of military vehicles. From 1998 until 2006, the experimental stimuli were block randomized, meaning that stimuli with similar difficulty levels (for example, in terms of distance from target, blur, noise, etc.) were presented together in blocks of approximately 24 images but the order of images within the block was random. Starting in 2006, complete randomization came into vogue, meaning that difficulty could change image to image. It was thought that this would provide a more statistically robust result. In this study we investigated the impact of the two types of randomization on performance in two groups of observers matched for skill to create equivalent groups. It is hypothesized that Soldiers in the Complete Randomized condition will have to shift their decision criterion more frequently than Soldiers in the Block Randomization group and this shifting is expected to impede performance so that Soldiers in the Block Randomized group perform better.
C1 [Moyer, Steve] US Army, RDECOM CERDEC Night Vis Elect Sensors Dir, Ft Belvoir, VA 22060 USA.
[Uhl, Elizabeth R.] Army Res Inst, Ft Benning, GA USA.
RP Moyer, S (reprint author), US Army, RDECOM CERDEC Night Vis Elect Sensors Dir, Ft Belvoir, VA 22060 USA.
NR 9
TC 0
Z9 0
U1 2
U2 2
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-568-1
J9 PROC SPIE
PY 2015
VL 9452
AR UNSP 94520M
DI 10.1117/12.2177803
PG 9
WC Engineering, Electrical & Electronic; Optics; Imaging Science &
Photographic Technology
SC Engineering; Optics; Imaging Science & Photographic Technology
GA BC9NS
UT WOS:000356673800021
ER
PT S
AU Olson, RF
AF Olson, Richard F., Jr.
BE Holst, GC
Krapels, KA
TI Computing the total atmospheric refraction for real-time optical imaging
sensor simulation
SO INFRARED IMAGING SYSTEMS: DESIGN, ANALYSIS, MODELING, AND TESTING XXVI
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Infrared Imaging Systems - Design, Analysis, Modeling, and
Testing XXVI
CY APR 21-23, 2015
CL Baltimore, MD
SP SPIE
DE Refraction; Snell's Law; Atmospheric Modeling; Atmospheric Optics;
Sensor Simulation; Hardware-in-the-Loop; IR Scene Generation
AB Fast and accurate computation of light path deviation due to atmospheric refraction is an important requirement for real-time simulation of optical imaging sensor systems. A large body of existing literature covers various methods for application of Snell's Law to the light path ray tracing problem. This paper provides a discussion of the adaptation to real time simulation of atmospheric refraction ray tracing techniques used in mid-1980's LOWTRAN releases. The refraction ray trace algorithm published in a LOWTRAN-6 technical report by Kneizys (et. al.) has been coded in MATLAB for development, and in C-language for simulation use. To this published algorithm we have added tuning parameters for variable path segment lengths, and extensions for Earth grazing and exoatmospheric "near Earth" ray paths. Model atmosphere properties used to exercise the refraction algorithm were obtained from tables published in another LOWTRAN-6 related report. The LOWTRAN-6 based refraction model is applicable to atmospheric propagation at wavelengths in the IR and visible bands of the electromagnetic spectrum. It has been used during the past two years by engineers at the U.S. Army Aviation and Missile Research, Development and Engineering Center (AMRDEC) in support of several advanced imaging sensor simulations. Recently, a faster (but sufficiently accurate) method using Gauss-Chebyshev Quadrature integration for evaluating the refraction integral was adopted.
C1 US Army, AMRDEC, Air & Missile Def Simulat SSDD, Redstone Arsenal, AL 35898 USA.
RP Olson, RF (reprint author), US Army, AMRDEC, Air & Missile Def Simulat SSDD, Redstone Arsenal, AL 35898 USA.
NR 12
TC 0
Z9 0
U1 0
U2 2
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-568-1
J9 PROC SPIE
PY 2015
VL 9452
AR 945211
DI 10.1117/12.2179771
PG 16
WC Engineering, Electrical & Electronic; Optics; Imaging Science &
Photographic Technology
SC Engineering; Optics; Imaging Science & Photographic Technology
GA BC9NS
UT WOS:000356673800033
ER
PT S
AU Preece, B
Du Bosq, T
Namazi, N
Nehmetallah, G
Kelly, KF
AF Preece, Bradley
Du Bosq, Todd
Namazi, Nader
Nehmetallah, Georges
Kelly, Kevin F.
BE Holst, GC
Krapels, KA
TI A Noise Model for the Design of a Compressive Sensing Imaging System
SO INFRARED IMAGING SYSTEMS: DESIGN, ANALYSIS, MODELING, AND TESTING XXVI
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Infrared Imaging Systems - Design, Analysis, Modeling, and
Testing XXVI
CY APR 21-23, 2015
CL Baltimore, MD
SP SPIE
AB The design and modeling of compressive sensing (CS) imagers is difficult due to the complexity and non-linearity of the system and reconstruction algorithm. The Night Vision Integrated Performance Model (NV-IPM) is a linear imaging system design tool that is very useful for complex system trade studies. The custom component generator, included in NV-IPM, will be used to include a recently published theory for CS that links measurement noise, easily calculated with NV-IPM, to the noise of the reconstructed CS image given the estimated sparsity of the scene and the number of measurements as input. As the sparsity will also depend on other factors such as the optical transfer function and the scene content, an empirical relationship will be developed between the linear model within NV-IPM and the non-linear reconstruction algorithm using measured test data. Using the theory, a CS imager varying the number of measurements will be compared to a notional traditional imager.
C1 [Preece, Bradley; Du Bosq, Todd] US Army, RDECOM CERDEC, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA.
[Namazi, Nader; Nehmetallah, Georges] Catholic Univ Amer, Washington, DC 20064 USA.
[Kelly, Kevin F.] Rice Univ, Houston, TX 77005 USA.
RP Preece, B (reprint author), US Army, RDECOM CERDEC, Night Vis & Elect Sensors Directorate, 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA.
NR 14
TC 1
Z9 1
U1 0
U2 0
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-568-1
J9 PROC SPIE
PY 2015
VL 9452
AR 94520L
DI 10.1117/12.2177275
PG 11
WC Engineering, Electrical & Electronic; Optics; Imaging Science &
Photographic Technology
SC Engineering; Optics; Imaging Science & Photographic Technology
GA BC9NS
UT WOS:000356673800020
ER
PT S
AU Preece, B
Tomkinson, D
Reynolds, J
AF Preece, Bradley
Tomkinson, Dave
Reynolds, Joseph
BE Holst, GC
Krapels, KA
TI An Independent Survey of Monochrome and Color Low Light Level TV Cameras
SO INFRARED IMAGING SYSTEMS: DESIGN, ANALYSIS, MODELING, AND TESTING XXVI
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Infrared Imaging Systems - Design, Analysis, Modeling, and
Testing XXVI
CY APR 21-23, 2015
CL Baltimore, MD
SP SPIE
AB Using the latest models from the U.S. Army Night Vision Electronic Sensors Directorate (NVESD), a survey of monochrome and color imaging systems at daylight and low light levels is conducted. Each camera system is evaluated and compared under several different assumptions, such as equivalent field of view with equal and variable f/#, common lens focal length and aperture, with high dynamic range comparisons and over several light levels. The modeling is done by use of the Targeting Task Performance (TTP) metric using the latest version of the Night Vision Integrated Performance Model ((NVIPM)-I-8). The comparison is performed over the V parameter, the main output of the TTP metric. Probability of identification (PID) versus range predictions are a direct non-linear mapping of the V parameter as a function of range. Finally, a comparison between the performance of a Bayer-filtered color camera, the Bayer-filtered color camera with the IR block filter removed, and a monochrome version of the same camera is also conducted.
C1 [Preece, Bradley; Tomkinson, Dave; Reynolds, Joseph] US Army, RDECOM CERDEC, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA.
RP Preece, B (reprint author), US Army, RDECOM CERDEC, Night Vis & Elect Sensors Directorate, 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA.
NR 9
TC 0
Z9 0
U1 0
U2 1
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-568-1
J9 PROC SPIE
PY 2015
VL 9452
AR UNSP 94520I
DI 10.1117/12.2179623
PG 13
WC Engineering, Electrical & Electronic; Optics; Imaging Science &
Photographic Technology
SC Engineering; Optics; Imaging Science & Photographic Technology
GA BC9NS
UT WOS:000356673800017
ER
PT S
AU Teaney, BP
Reynolds, JP
Du Bosq, TW
Repasi, E
AF Teaney, Brian P.
Reynolds, Joseph P.
Du Bosq, Todd W.
Repasi, Endre
BE Holst, GC
Krapels, KA
TI A TRM4 component for the Night Vision Integrated Performance Model
(NV-IPM)
SO INFRARED IMAGING SYSTEMS: DESIGN, ANALYSIS, MODELING, AND TESTING XXVI
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Infrared Imaging Systems - Design, Analysis, Modeling, and
Testing XXVI
CY APR 21-23, 2015
CL Baltimore, MD
SP SPIE
AB The Thermal Range Model (TRM4)(1) developed by the Fraunhofer IOSB of Germany is a commonly used performance model for military target acquisition systems. There are many similarities between the U.S Army Night Vision Integrated Performance Model (NV-IPM)(2) and TRM4. Almost all of the camera performance characterizations, such as signal-to-noise calculations and modulation transfer theory are identical, only the human vision model and performance metrics differ. Utilizing the new Custom Component Generator in the NV-IPM we develop a component to calculate the Average Modulation at Optimal Phase (AMOP) and Minimum Difference Signal Perceived (MDSP) calculations used in TRM4. The results will be compared with the actual TRM4 results for a variety of imaging systems. This effort demonstrates that the NV-IPM is a versatile system design tool which can easily be extended to include a variety of image quality and performance metrics.
C1 [Teaney, Brian P.; Reynolds, Joseph P.; Du Bosq, Todd W.] US Army, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA.
[Repasi, Endre] Fraunhofer Inst Optron Syst Technol & Image Explo, D-76275 Ettlingen, Germany.
RP Teaney, BP (reprint author), US Army, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA.
NR 6
TC 0
Z9 0
U1 0
U2 1
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-568-1
J9 PROC SPIE
PY 2015
VL 9452
AR 94520H
DI 10.1117/12.2180002
PG 10
WC Engineering, Electrical & Electronic; Optics; Imaging Science &
Photographic Technology
SC Engineering; Optics; Imaging Science & Photographic Technology
GA BC9NS
UT WOS:000356673800016
ER
PT S
AU Teaney, BP
Haefner, DP
Burks, SD
AF Teaney, Brian P.
Haefner, David P.
Burks, Stephen D.
BE Holst, GC
Krapels, KA
TI Custom Component Generation in the Night Vision Integrated Performance
Model
SO INFRARED IMAGING SYSTEMS: DESIGN, ANALYSIS, MODELING, AND TESTING XXVI
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Infrared Imaging Systems - Design, Analysis, Modeling, and
Testing XXVI
CY APR 21-23, 2015
CL Baltimore, MD
SP SPIE
AB The latest version of the U.S. Army imager performance model, the Night, Vision Integrated Performance Model (NV-IPM), is HOW contained within a single, system engineering Oriented design environment. This new model interface allows sensor systems to be represented using modular, reusable components. A new feature, added in version 1.3 of the NV-IPM, allows users to create custom components which can be incorporated into modeled systems. The ability to modify existing component definitions and create entirely new components in the model greatly enhances the extensibility of the model architecture. In this paper we will discuss the structure of the custom component and parameter generators and provide several examples where this feature can be used to easily create new and unique component definitions within the model.
C1 [Teaney, Brian P.; Haefner, David P.; Burks, Stephen D.] US Army, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA.
RP Teaney, BP (reprint author), US Army, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA.
NR 2
TC 0
Z9 0
U1 0
U2 0
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-568-1
J9 PROC SPIE
PY 2015
VL 9452
AR UNSP 94520Q
DI 10.1117/12.2180249
PG 12
WC Engineering, Electrical & Electronic; Optics; Imaging Science &
Photographic Technology
SC Engineering; Optics; Imaging Science & Photographic Technology
GA BC9NS
UT WOS:000356673800024
ER
PT S
AU Teaney, BP
Tomkinson, DM
Hixson, JG
AF Teaney, Brian P.
Tomkinson, David M.
Hixson, Jonathan G.
BE Holst, GC
Krapels, KA
TI Legacy modeling and range prediction comparison: NV-IPM versus SSCamIP
and NVTherm
SO INFRARED IMAGING SYSTEMS: DESIGN, ANALYSIS, MODELING, AND TESTING XXVI
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Infrared Imaging Systems - Design, Analysis, Modeling, and
Testing XXVI
CY APR 21-23, 2015
CL Baltimore, MD
SP SPIE
AB NVESDs new integrated sensor performance model, NV-IPM, replaces the discrete spectral band models that preceded it (NVTherm, SSCamIP, etc.). Many advanced modeling functions are now more readily available, easier to implement, and integrated within a single model architecture. For the legacy model user with ongoing modeling duties, however, the conversion of legacy decks to NV-IPM is of more immediate concern than mastering the many "power features" now available. This paper addresses the processes for the legacy model user to make a smooth transition to NV-IPM, including the conversion of legacy sensor decks to NV-IPM format decks, differences in parameters entered in the new versus old model, and a comparison of the predicted performance differences between NV-IPM and legacy models. Examples are presented to demonstrate the ease of sensor deck conversion from legacy models and to highlight enhanced model capabilities available with minimal transition effort.
C1 [Teaney, Brian P.; Tomkinson, David M.; Hixson, Jonathan G.] US Army, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA.
RP Teaney, BP (reprint author), US Army, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA.
NR 10
TC 1
Z9 1
U1 0
U2 0
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-568-1
J9 PROC SPIE
PY 2015
VL 9452
AR 94520P
DI 10.1117/12.2179371
PG 12
WC Engineering, Electrical & Electronic; Optics; Imaging Science &
Photographic Technology
SC Engineering; Optics; Imaging Science & Photographic Technology
GA BC9NS
UT WOS:000356673800023
ER
PT B
AU Debboun, M
Frances, SP
Strickman, DA
AF Debboun, Mustapha
Frances, Stephen P.
Strickman, Daniel A.
BE Debboun, M
Frances, SP
Strickman, DA
TI Insect Repellents Handbook Preface
SO INSECT REPELLENTS HANDBOOK, 2ND EDITION
LA English
DT Editorial Material; Book Chapter
C1 [Debboun, Mustapha] US Army Med Dept Ctr & Sch, Dept Prevent Hlth Serv, Ft Sam Houston, TX 78234 USA.
[Frances, Stephen P.] Australian Army Malaria Inst, Gallipoli Barracks Enogg, Qld, Australia.
[Strickman, Daniel A.] ARS, George Washington Carver Ctr, USDA, Beltsville, MD USA.
RP Debboun, M (reprint author), US Army Med Dept Ctr & Sch, Dept Prevent Hlth Serv, Ft Sam Houston, TX 78234 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU CRC PRESS-TAYLOR & FRANCIS GROUP
PI BOCA RATON
PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA
BN 978-1-4665-5358-3; 978-1-4665-5355-2
PY 2015
BP XI
EP XI
PG 1
WC Entomology
SC Entomology
GA BC7MS
UT WOS:000355003300001
ER
PT B
AU Rutledge, LC
Mehr, ZA
Debboun, M
AF Rutledge, Louis C.
Mehr, Zia A.
Debboun, Mustapha
BE Debboun, M
Frances, SP
Strickman, DA
TI Testing Methods for Insect Repellents
SO INSECT REPELLENTS HANDBOOK, 2ND EDITION
LA English
DT Article; Book Chapter
ID TOPICAL MOSQUITO REPELLENTS; SYSTEM; ATTRACTANTS; BLOOD; MODEL
C1 [Rutledge, Louis C.] US Army, Mill Valley, CA USA.
[Debboun, Mustapha] US Army Med Dept Ctr & Sch, Dept Prevent Hlth Serv, Ft Sam Houston, TX USA.
NR 71
TC 0
Z9 0
U1 0
U2 0
PU CRC PRESS-TAYLOR & FRANCIS GROUP
PI BOCA RATON
PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA
BN 978-1-4665-5358-3; 978-1-4665-5355-2
PY 2015
BP 159
EP 178
PG 20
WC Entomology
SC Entomology
GA BC7MS
UT WOS:000355003300009
ER
PT B
AU Debboun, M
Paluch, G
Lindsay, D
AF Debboun, Mustapha
Paluch, Gretchen
Lindsay, David
BE Debboun, M
Frances, SP
Strickman, DA
TI Use of Chemical Mixtures as Insecticides and Repellents
SO INSECT REPELLENTS HANDBOOK, 2ND EDITION
LA English
DT Article; Book Chapter
ID AEDES-AEGYPTI DIPTERA; INOPHYLLUM NUT OIL; ARMATUM SEED OIL;
MOSQUITO-REPELLENT; MALARIA VECTORS; STOMOXYS-CALCITRANS; PERSONAL
PROTECTION; ENHANCED REPELLENCY; FIELD CONDITIONS; BINARY-MIXTURES
C1 [Debboun, Mustapha] US Army Med Dept Ctr & Sch, Dept Prevent Hlth Serv, Ft Sam Houston, TX 78234 USA.
RP Debboun, M (reprint author), US Army Med Dept Ctr & Sch, Dept Prevent Hlth Serv, Ft Sam Houston, TX 78234 USA.
NR 56
TC 0
Z9 0
U1 0
U2 0
PU CRC PRESS-TAYLOR & FRANCIS GROUP
PI BOCA RATON
PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA
BN 978-1-4665-5358-3; 978-1-4665-5355-2
PY 2015
BP 283
EP 290
PG 8
WC Entomology
SC Entomology
GA BC7MS
UT WOS:000355003300016
ER
PT B
AU Qualls, WA
Xue, RD
Beier, JC
Debboun, M
AF Qualls, Whitney A.
Xue, Rui-De
Beier, John C.
Debboun, Mustapha
BE Debboun, M
Frances, SP
Strickman, DA
TI Alterations of Blood-Feeding Behavior and Repellent Response of
Pathogen-Infected Biting Flies
SO INSECT REPELLENTS HANDBOOK, 2ND EDITION
LA English
DT Article; Book Chapter
ID AEDES-AEGYPTI DIPTERA; LA-CROSSE VIRUS; SINDBIS VIRUS; DENGUE VIRUS;
PLASMODIUM-FALCIPARUM; DEET REPELLENCY; CULICIDAE; MOSQUITO; ALBOPICTUS;
VECTOR
C1 [Qualls, Whitney A.; Beier, John C.] Univ Miami Miller Sch Med, Dept Publ Hlth Sci, Miami, FL 33199 USA.
[Xue, Rui-De] Anastasia Mosquito Control Dist, St Augustine, FL USA.
[Debboun, Mustapha] US Army Med Dept Ctr & Sch, Dept Prevent Hlth Serv, Ft Sam Houston, TX USA.
RP Qualls, WA (reprint author), Univ Miami Miller Sch Med, Dept Publ Hlth Sci, Miami, FL 33199 USA.
NR 25
TC 0
Z9 0
U1 1
U2 1
PU CRC PRESS-TAYLOR & FRANCIS GROUP
PI BOCA RATON
PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA
BN 978-1-4665-5358-3; 978-1-4665-5355-2
PY 2015
BP 351
EP 356
PG 6
WC Entomology
SC Entomology
GA BC7MS
UT WOS:000355003300021
ER
PT B
AU Xue, RD
Muller, GC
Debboun, M
AF Xue, Rui-De
Muller, Gunter C.
Debboun, Mustapha
BE Debboun, M
Frances, SP
Strickman, DA
TI Insect Repellents for Other Potential Use
SO INSECT REPELLENTS HANDBOOK, 2ND EDITION
LA English
DT Article; Book Chapter
ID AEDES-AEGYPTI L; OVIPOSITION DETERRENTS; CULEX-QUINQUEFASCIATUS;
LABORATORY EVALUATION; ANOPHELES-QUADRIMACULATUS; MOSQUITO OVIPOSITION;
LARVICIDAL ACTIVITY; DIPTERA-CULICIDAE; FIELD-EVALUATION; ESSENTIAL OILS
C1 [Xue, Rui-De] Anastasia Mosquito Control Dist, St Augustine, FL 32080 USA.
[Muller, Gunter C.] Hebrew Univ Jerusalem, Dept Microbiol & Mol, Jerusalem, Israel.
[Debboun, Mustapha] US Army Med Dept Ctr & Sch, Dept Prevent Hlth Serv, Ft Sam Houston, TX USA.
RP Xue, RD (reprint author), Anastasia Mosquito Control Dist, St Augustine, FL 32080 USA.
NR 29
TC 0
Z9 0
U1 0
U2 0
PU CRC PRESS-TAYLOR & FRANCIS GROUP
PI BOCA RATON
PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA
BN 978-1-4665-5358-3; 978-1-4665-5355-2
PY 2015
BP 357
EP 365
PG 9
WC Entomology
SC Entomology
GA BC7MS
UT WOS:000355003300022
ER
PT B
AU Debboun, M
Frances, SP
Strickman, D
AF Debboun, Mustapha
Frances, Stephen P.
Strickman, Daniel
BE Debboun, M
Frances, SP
Strickman, DA
TI Future of Insect Repellents
SO INSECT REPELLENTS HANDBOOK, 2ND EDITION
LA English
DT Article; Book Chapter
C1 [Debboun, Mustapha] US Army Med Dept Ctr & Sch, Dept Prevent Hlth Serv, Ft Sam Houston, TX 78234 USA.
[Frances, Stephen P.] Australian Army Malaria Inst, Gallipoli Barracks Enogg, Qld, Australia.
[Strickman, Daniel] ARS, George Washington Carver Ctr, USDA, Beltsville, MD USA.
RP Debboun, M (reprint author), US Army Med Dept Ctr & Sch, Dept Prevent Hlth Serv, Ft Sam Houston, TX 78234 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU CRC PRESS-TAYLOR & FRANCIS GROUP
PI BOCA RATON
PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA
BN 978-1-4665-5358-3; 978-1-4665-5355-2
PY 2015
BP 367
EP 369
PG 3
WC Entomology
SC Entomology
GA BC7MS
UT WOS:000355003300023
ER
PT S
AU Krych, DE
Lange-Maney, S
McDaniel, P
Glodek, W
AF Krych, Daniel E.
Lange-Maney, Stephen
McDaniel, Patrick
Glodek, William
BE Kelmelis, EJ
TI Investigating Weaknesses in Android Certificate Security
SO MODELING AND SIMULATION FOR DEFENSE SYSTEMS AND APPLICATIONS X
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Modeling and Simulation for Defense Systems and
Applications X
CY APR 21, 2015
CL Baltimore, MD
SP SPIE
DE Android; Android Security; Android Certificate; RSA
AB Android's application market relies on secure certificate generation to establish trust between applications and their users; yet, cryptography is often not a priority for application developers and many fail to take the necessary security precautions. Indeed, there is cause for concern: several recent high-profile studies have observed a pervasive lack of entropy on Web-systems leading to the factorization of private keys.(1) Sufficient entropy, or randomness, is essential to generate secure key pairs and combat predictable key generation. In this paper, we analyze the security of Android certificates. We investigate the entropy present in 550,000 Android application certificates using the Quasilinear CCD finding algorithm.(1) Our results show that while the lack of entropy does not appear to be as ubiquitous in the mobile markets as on Web-systems, there is substantial reuse of certificatesonly one third of the certificates in our dataset were unique. In other words, we find that organizations frequently reuse certificates for different applications. While such a practice is acceptable under Google's specifications for a single developer, we find that in some cases the same certificates are used for a myriad of developers, potentially compromising Android's intended trust relationships. Further, we observed duplicate certificates being used by both malicious and non-malicious applications. The top 3 repeated certificates present in our dataset accounted for a total of 11,438 separate APKs. Of these applications, 451, or roughly 4%, were identified as malicious by antivirus services.
C1 [Krych, Daniel E.; Lange-Maney, Stephen; McDaniel, Patrick] Penn State Univ, Dept Comp Sci & Engn, University Pk, PA 16802 USA.
[Glodek, William] US Army, Res Lab, Adelphi, MD USA.
RP Krych, DE (reprint author), Penn State Univ, Dept Comp Sci & Engn, University Pk, PA 16802 USA.
EM dek5156@cse.psu.edu; mcdaniel@cse.psu.edu; william.j.glodek.civ@mail.mil
NR 9
TC 0
Z9 0
U1 1
U2 2
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-594-0
J9 PROC SPIE
PY 2015
VL 9478
AR 947804
DI 10.1117/12.2177498
PG 9
WC Engineering, Electrical & Electronic; Optics
SC Engineering; Optics
GA BC9NT
UT WOS:000356674500002
ER
PT S
AU Poshtyar, A
Elangovan, V
Shirkhodaie, A
Chan, A
Hu, SW
AF Poshtyar, Azin
Elangovan, Vinayak
Shirkhodaie, Amir
Chan, Alex
Hu, Shuowen
BE Kelmelis, EJ
TI Physical Environment Virtualization for Human Activities Recognition
SO MODELING AND SIMULATION FOR DEFENSE SYSTEMS AND APPLICATIONS X
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Modeling and Simulation for Defense Systems and
Applications X
CY APR 21, 2015
CL Baltimore, MD
SP SPIE
DE Group Activity Modeling; Group Activity Recognition; Virtual Environment
Modeling and Simulation; Virtual Sensors Modeling; Large-Scale System
Modeling
AB Human activity recognition research relies heavily on extensive datasets to verify and validate performance of activity recognition algorithms. However, obtaining real datasets are expensive and highly time consuming. A physics-based virtual simulation can accelerate the development of context based human activity recognition algorithms and techniques by generating relevant training and testing videos simulating diverse operational scenarios. In this paper, we discuss in detail the requisite capabilities of a virtual environment to aid as a test bed for evaluating and enhancing activity recognition algorithms. To demonstrate the numerous advantages of virtual environment development, a newly developed virtual environment simulation modeling (VESM) environment is presented here to generate calibrated multi-source imagery datasets suitable for development and testing of recognition algorithms for context-based human activities. The VESM environment serves as a versatile test bed to generate a vast amount of realistic data for training and testing of sensor processing algorithms. To demonstrate the effectiveness of VESM environment, we present various simulated scenarios and processed results to infer proper semantic annotations from the high fidelity imagery data for human-vehicle activity recognition under different operational contexts.
C1 [Poshtyar, Azin; Elangovan, Vinayak; Shirkhodaie, Amir] Tennessee State Univ, Dept Mech & Mfg Engn, Ctr Excellence Battlefield Senor Fus, Nashville, TN 37209 USA.
[Chan, Alex; Hu, Shuowen] US Army, Image Proc Branch, Res Lab, Adelphi, MD 20783 USA.
RP Poshtyar, A (reprint author), Tennessee State Univ, Dept Mech & Mfg Engn, Ctr Excellence Battlefield Senor Fus, 3500 John Merritt Blvd, Nashville, TN 37209 USA.
NR 13
TC 0
Z9 0
U1 0
U2 3
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-594-0
J9 PROC SPIE
PY 2015
VL 9478
AR 94780I
DI 10.1117/12.2178547
PG 12
WC Engineering, Electrical & Electronic; Optics
SC Engineering; Optics
GA BC9NT
UT WOS:000356674500012
ER
PT S
AU Moulton, CL
Krzywicki, AT
Hepp, JJ
Harrell, J
Kogut, M
AF Moulton, Christine L.
Krzywicki, Alan T.
Hepp, Jared J.
Harrell, John
Kogut, Michael
BE Suresh, R
TI Open architecture design and approach for the Integrated Sensor
Architecture (ISA)
SO OPEN ARCHITECTURE/OPEN BUSINESS MODEL NET-CENTRIC SYSTEMS AND DEFENSE
TRANSFORMATION 2015
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Open Architecture/Open Business Model Net-Centric Systems
and Defense Transformation
CY APR 21-23, 2015
CL Baltimore, MD
SP SPIE
DE Open Architecture; Service Oriented Architecture
AB Integrated Sensor Architecture (ISA) is designed in response to stovepiped integration approaches. The design, based on the principles of Service Oriented Architectures (SOA) and Open Architectures, addresses the problem of integration, and is not designed for specific sensors or systems. The use of SOA and Open Architecture approaches has led to a flexible, extensible architecture.
Using these approaches, and supported with common data formats, open protocol specifications, and Department of Defense Architecture Framework (DoDAF) system architecture documents, an integration-focused architecture has been developed. ISA can help move the Department of Defense (DoD) from costly stovepipe solutions to a more cost-effective plug-and-play design to support interoperability.
C1 [Moulton, Christine L.; Krzywicki, Alan T.] US Army, RDECOM CERDEC Night Vis & Elect Sensors Directora, Ft Belvoir, VA 22060 USA.
[Hepp, Jared J.; Harrell, John] Oakwood Controls Corp, Glen Rock, PA USA.
[Kogut, Michael] SAIC, Mclean, VA USA.
RP Moulton, CL (reprint author), US Army, RDECOM CERDEC Night Vis & Elect Sensors Directora, Ft Belvoir, VA 22060 USA.
NR 10
TC 0
Z9 0
U1 2
U2 3
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-595-7
J9 PROC SPIE
PY 2015
VL 9479
AR 94790C
DI 10.1117/12.2177842
PG 6
WC Engineering, Electrical & Electronic; Optics
SC Engineering; Optics
GA BC9NW
UT WOS:000356675900006
ER
PT S
AU Slocum, DM
Goyette, TM
Giles, RH
Nixon, WE
AF Slocum, David M.
Goyette, Thomas M.
Giles, Robert H.
Nixon, William E.
BE Anwar, MF
Crowe, TW
Manzur, T
TI Experimental determination of terahertz atmospheric absorption
parameters
SO TERAHERTZ PHYSICS, DEVICES, AND SYSTEMS IX: ADVANCED APPLICATIONS IN
INDUSTRY AND DEFENSE
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Terahertz Physics, Devices, and Systems IX - Advanced
Applications in Industry and Defense
CY APR 22-23, 2015
CL Baltimore, MD
SP SPIE
DE water vapor; methanol; continuum; terahertz; spectroscopy; multispectral
fitting
ID WATER-VAPOR CONTINUUM; FOURIER-TRANSFORM SPECTROMETER; RESOLVED
EXPERIMENTAL SPECTRUM; SOUTHEASTERN UNITED-STATES; METHYL ALCOHOL;
METHANOL CH3OH; MAUNA-KEA; SUBMILLIMETER; LINE; GHZ
AB The terahertz frequency regime is often used as the 'chemical fingerprint' region of the electromagnetic spectrum since many molecules exhibit a dense selection of rotational and vibrational transitions. Water is a major component of the atmosphere and since it has a large dipole moment the propagation of terahertz radiation will be dominated by atmospheric effects. This study will present the results of high-resolution broadband measurements of the terahertz atmospheric absorption and detail the technique for directly measuring the pressure broadening coefficients, absolute absorption coefficients, line positions, and continuum effects. Differences between these measured parameters and those tabulated in HITRAN will be discussed. Once the water vapor absorption was characterized, the same technique was used to measure the line parameters for methanol, a trace gas of interest within Earth's atmosphere. Methanol has a dense absorption spectrum in the terahertz frequency region and is an important molecule in fields such as environmental monitoring, security, and astrophysics. The data obtained in the present study will be of immediate use for the remote sensing community, as it is uncommon to measure this many independent parameters as well as to measure the absolute absorption of the transitions. Current models rely on tabulated databases of calculated values for the line parameters measured in this study. Differences between the measured data and those in the databases will be highlighted and discussed.
C1 [Slocum, David M.; Goyette, Thomas M.; Giles, Robert H.] Univ Massachusetts, Submillimeter Wave Technol Lab, Lowell, MA 01854 USA.
[Nixon, William E.] US Army, Natl Ground Intelligence Ctr, Charlottesville, VA 22911 USA.
RP Slocum, DM (reprint author), Univ Massachusetts, Submillimeter Wave Technol Lab, Lowell, MA 01854 USA.
EM David_Slocum@student.uml.edu
NR 41
TC 0
Z9 0
U1 0
U2 4
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-599-5
J9 PROC SPIE
PY 2015
VL 9483
AR 94830O
DI 10.1117/12.2176455
PG 12
WC Engineering, Electrical & Electronic; Optics; Physics, Applied
SC Engineering; Optics; Physics
GA BC9TK
UT WOS:000356865100013
ER
PT S
AU Fu, C
Arguello, H
Sadler, BM
Arce, GR
AF Fu, Chen
Arguello, Henry
Sadler, Brain M.
Arce, Gonzalo R.
BE Ahmad, F
TI Compressive Spectral Polarization Imaging With Coded Micropolarizer
Array
SO COMPRESSIVE SENSING IV
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Compressive Sensing IV
CY APR 22-24, 2015
CL Baltimore, MD
SP SPIE
DE Compressive sensing; Spectral and polarization imaging; Rotating prism
ID POLARIMETRY
AB We present a compressive spectral polarization imager based on a prism which is rotated to different angles as the measurement shots are taken, and a colored detector with a micropolarizer array. The prism shears the scene along one spatial axis according to its wavelength components. The scene is then projected to different locations on the detector as measurement shots are taken. Composed of 0, 45, 90, 135 linear micropolarizers, the pixels of the micropolarizer array matched to that of the colored detector, thus the first three Stokes parameters of the scene are compressively sensed. The four dimensional (4D) data cube is thus projected onto the two dimensional (2D) FPA. Designed patterns for the micropolarizer and the colored detector are applied so as to improve the reconstruction problem. The 4D spectral-polarization data cube is reconstructed from the 2D measurements via nonlinear optimization with sparsity constraints. Computer simulations are performed and the performance of designed patterns is compared with random patterns.
C1 [Fu, Chen; Arce, Gonzalo R.] Univ Delaware, Dept Elect & Comp Engn, Newark, DE 19716 USA.
[Arguello, Henry] Univ Ind Santander, Bucaramanga, Colombia.
[Sadler, Brain M.] AMSRL CI CN, Army Res Lab, Adelphi, MD 20783 USA.
RP Fu, C (reprint author), Univ Delaware, Dept Elect & Comp Engn, Newark, DE 19716 USA.
NR 9
TC 0
Z9 0
U1 1
U2 7
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-600-8
J9 PROC SPIE
PY 2015
VL 9484
DI 10.1117/12.2177813
PG 7
WC Engineering, Electrical & Electronic; Optics; Physics, Applied
SC Engineering; Optics; Physics
GA BC9MK
UT WOS:000356619200007
ER
PT J
AU Grujicic, M
Ramaswami, S
Snipes, J
Galgalikar, R
Yavari, R
Yen, CF
Cheeseman, B
Montgomery, J
AF Grujicic, Mica
Ramaswami, Subrahmanian
Snipes, Jennifer
Galgalikar, Rohan
Yavari, Ramin
Yen, Chian-Fong
Cheeseman, Bryan
Montgomery, Jonathan
TI Modeling of ballistic-failure mechanisms in gas metal arc welds of mil
a46100 armor-grade steel
SO ENGINEERING COMPUTATIONS
LA English
DT Article
DE MIL A46100 armor-grade steel; Ballistic limit; Gas metal arc welding
(GMAW) Process modeling
ID AA5083-H116 ALUMINUM PLATES; STAINLESS-STEEL; PROJECTILES; PERFORATION;
EVOLUTION; REAUSTENITIZATION; MICROSTRUCTURE; PERFORMANCE
AB Purpose - The purpose of this paper is to discuss the recently developed multi-physics computational model for the conventional Gas Metal Arc Welding (GMAW) joining process that has been upgraded with respect to its predictive capabilities regarding the spatial distribution of the mechanical properties controlling the ballistic limit (i.e. penetration resistance) of the weld.
Design/methodology/approach - The original model consists of five modules, each dedicated to handling a specific aspect of the GMAW process, i.e.: electro-dynamics of the welding-gun; radiation-/convection-controlled heat transfer from the electric arc to the workpiece and mass transfer from the filler-metal consumable electrode to the weld; prediction of the temporal evolution and the spatial distribution of thermal and mechanical fields within the weld region during the GMAW joining process; the resulting temporal evolution and spatial distribution of the material microstructure throughout the weld region; and spatial distribution of the as-welded material mechanical properties. The model is upgraded through the introduction of the sixth module in the present work in recognition of the fact that in thick steel GMAW weldments, the overall ballistic performance of the armor may become controlled by the (often inferior) ballistic limits of its weld (fusion and heat-affected) zones.
Findings - The upgraded GMAW process model is next applied to the case of butt-welding of MIL A46100 (a prototypical high-hardness armor-grade martensitic steel) workpieces using filler-metal electrodes made of the same material. The predictions of the upgraded GMAW process model pertaining to the spatial distribution of the material microstructure and ballistic-limit-controlling mechanical properties within the MIL A46100 butt-weld are found to be consistent with general expectations and prior observations.
Originality/value - To the authors' knowledge, the present work is the first reported attempt to establish, using computational modeling, functional relationships between the GMAW process parameters and the mechanical properties controlling the ballistic limit of the resulting weld.
C1 [Grujicic, Mica; Ramaswami, Subrahmanian; Snipes, Jennifer; Galgalikar, Rohan; Yavari, Ramin] Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA.
[Yen, Chian-Fong; Cheeseman, Bryan; Montgomery, Jonathan] Army Res Lab, Survivabil Mat Branch, Aberdeen Proving Ground, MD USA.
RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA.
EM gmica@g.clemson.edu
FU Army Research Office [W911NF-11-1-0207, W911NF-11-1-0518]
FX The material presented in this paper is based on work supported by two
Army Research Office sponsored grants entitled "Friction Stir Welding
Behavior of Selected 2000-series and 5000-series Aluminum Alloys"
(Contract Number W911NF-11-1-0207), and "Concept Validation and
Optimization for a Vent-based Mine-blast Mitigation System" (Contract
Number W911NF-11-1-0518). The authors are indebted to Dr Ralph A.
Anthenien, Jr and Dr Bryan Glaz of ARO for their continuing support and
interest in the present work.
NR 51
TC 1
Z9 1
U1 1
U2 7
PU EMERALD GROUP PUBLISHING LIMITED
PI BINGLEY
PA HOWARD HOUSE, WAGON LANE, BINGLEY BD16 1WA, W YORKSHIRE, ENGLAND
SN 0264-4401
EI 1758-7077
J9 ENG COMPUTATION
JI Eng. Comput.
PY 2015
VL 32
IS 3
BP 705
EP 741
DI 10.1108/EC-01-2014-0010
PG 37
WC Computer Science, Interdisciplinary Applications; Engineering,
Multidisciplinary; Mathematics, Interdisciplinary Applications;
Mechanics
SC Computer Science; Engineering; Mathematics; Mechanics
GA CJ9NS
UT WOS:000355829900008
ER
PT J
AU Tran, DT
Zhang, SS
AF Tran, Dat T.
Zhang, Sheng S.
TI Chemical stability and electrochemical characteristics of FeS
microcrystals as the cathode material of rechargeable lithium batteries
SO JOURNAL OF MATERIALS CHEMISTRY A
LA English
DT Article
ID ION BATTERIES; ANODE MATERIAL; PERFORMANCE; STORAGE; NANOSTRUCTURES;
ELECTROLYTE; NANOSHEETS; CHEMISTRY
AB Carbon precursor coated iron monosulphide (CP@FeS) microcrystals are synthesized by a facile one-pot solvothermal reaction of FeSO4 and two moles of Na2S with sucrose as the carbon source, and evaluated as the cathode material of rechargeable lithium batteries. The results show that the obtained CP@FeS microcrystals consist of two FeS phases and contain a small amount of sulphur. In storage, FeS transforms into Fe3S4, which is further oxidized by oxygen in air to release elemental sulphur. Interestingly, such transformation and oxidation are found to affect only the first discharge voltage profile with negligible impact on the specific capacity and cycling performance of a Li/FeS battery. It is shown that the cyclability of the Li/FeS battery is greatly affected by the electrolyte solvent and charging cutoff voltage. In this paper, we discuss the chemical stability and redox mechanism of the FeS cathode material, and investigate the factors that affect the cycling performance of Li/FeS batteries.
C1 [Tran, Dat T.; Zhang, Sheng S.] US Army Res Lab, Energy & Power Div, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
RP Zhang, SS (reprint author), US Army Res Lab, Energy & Power Div, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
EM shengshui.zhang.civ@mail.mil
RI Zhang, Sheng/A-4456-2012
OI Zhang, Sheng/0000-0003-4435-4110
NR 22
TC 9
Z9 9
U1 25
U2 106
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 2050-7488
EI 2050-7496
J9 J MATER CHEM A
JI J. Mater. Chem. A
PY 2015
VL 3
IS 23
BP 12240
EP 12246
DI 10.1039/c5ta02048d
PG 7
WC Chemistry, Physical; Energy & Fuels; Materials Science,
Multidisciplinary
SC Chemistry; Energy & Fuels; Materials Science
GA CJ8FX
UT WOS:000355736700017
ER
PT S
AU Edwards, E
Brantley, CL
Ruffin, PB
Crutcher, S
AF Edwards, Eugene
Brantley, Christina L.
Ruffin, Paul B.
Crutcher, Sihon
BE Varadan, VK
TI Nano Devices & Concepts for Condition-Based Maintenance of Military
Systems
SO NANOSENSORS, BIOSENSORS, AND INFO-TECH SENSORS AND SYSTEMS 2015
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Nanosensors, Biosensors, and Info-Tech Sensors and Systems
CY MAR 09-11, 2015
CL San Diego, CA
SP SPIE, American Soc Mech Engineers, Intelligent Mat Forum, Jet Propuls Lab, Natl Sci Fdn
DE Nano devices; condition-based maintenance; propellant stabilizer;
acoustic; spectral sensing
AB There is a continuous need for the Department of Defense (DoD) and its associate weaponry supply organizations to consistently evaluate the usability of weapons that exhibit deteriorative characteristics over a period of time. Along the same lines, enhanced condition-based maintenance evaluation procedures are necessary to mitigate the risk and reduce the cost of catastrophic failure of varying inventories of military systems. One significant area of research is the verification of the existence of sufficient concentrations of propellant stabilizer in the motor of stored missiles. Results from developed apparatuses can help collect degradation information to establish indicators that the missile's double-based solid propellant is still functional after long-term storage. Other mechanisms are being developed for the assessment of degradation in gun barrel rifling. The research outlined in this paper summarizes the Army Aviation and Missile Research, Development, & Engineering Center's (AMRDEC's) investigative approaches relative to the use of spectral-optical and acoustical methodologies for detecting deteriorations in both propellant and the apparatus that engages munitions. A spectral-optical sensing approach is presented that is based on distinctive light collecting optical fiber -based developments designed to detect the concentration of propellant ingredients. The use of diagnostic acoustic sensing mechanisms is delineated to include the use of commercially available transducer-based readers to collect information that is indicative of the distance that acoustic waves travel through weaponry components. In collaboration with several AMRDEC industry and academia supporters, this paper outlines sensing methods that are under consideration for implementation onto weapon systems. Conceptional approaches, experimental configurations, and laboratory results are presented for each initiative. Cost-savings and improved weaponry health monitoring capabilities are expected to derive from each sensing mechanisms.
C1 [Edwards, Eugene; Brantley, Christina L.; Crutcher, Sihon] US Army Res Dev & Engn Command, Redstone Arsenal, AL 35898 USA.
Alabama A&M Univ, Coll Phys Chem & Engn, Normal, AL 35811 USA.
RP Edwards, E (reprint author), US Army Res Dev & Engn Command, Redstone Arsenal, AL 35898 USA.
EM eugene.edwards.civ@mail.mil
NR 7
TC 1
Z9 1
U1 0
U2 1
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-537-7
J9 PROC SPIE
PY 2015
VL 9434
AR 943402
DI 10.1117/12.2084422
PG 11
WC Engineering, Electrical & Electronic; Optics; Physics, Applied
SC Engineering; Optics; Physics
GA BC8PT
UT WOS:000355991300001
ER
PT J
AU Qiu, HW
Patel, RB
Damavarapu, RS
Stepanov, V
AF Qiu, Hongwei
Patel, Rajen B.
Damavarapu, Reddy S.
Stepanov, Victor
TI Nanoscale 2CL-20.HMX high explosive cocrystal synthesized by bead
milling
SO CRYSTENGCOMM
LA English
DT Article
ID SHOCK SENSITIVITY; ENERGETIC COCRYSTAL; RDX; CRYSTALS; CL-20
AB Energetic nanoscale 2CL-20.HMX, a cocrystal of CL-20 and HMX in a 2 : 1 molar ratio, was prepared by a novel method of bead milling an aqueous suspension of epsilon-CL-20 and beta-HMX. The conversion of the coformers to the cocrystal form was monitored by powder X-ray diffraction (XRD) and scanning electron microscopy (SEM) analysis of specimens sampled at various milling times. Complete conversion to the cocrystal form was achieved by 60 minutes of milling. Rounded 2CL-20.HMX cocrystal particles with a mean size below 200 nm were produced. A mechanism for the conversion of the coformers to the cocrystalline form is postulated based on the experimental results. As an inherently safe manufacturing method, the aqueous bead milling process has great potential in advancing cocrystal research and applications in the field of energetic materials.
C1 [Qiu, Hongwei] Leidos Inc, Engn & Technol Solut Div, Picatinny Arsenal, NJ 07806 USA.
[Patel, Rajen B.; Damavarapu, Reddy S.; Stepanov, Victor] US Army, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07806 USA.
RP Qiu, HW (reprint author), Leidos Inc, Engn & Technol Solut Div, Picatinny Arsenal, NJ 07806 USA.
EM rajen.b.patel.civ@mail.mil
NR 27
TC 3
Z9 3
U1 8
U2 34
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 1466-8033
J9 CRYSTENGCOMM
JI Crystengcomm
PY 2015
VL 17
IS 22
BP 4080
EP 4083
DI 10.1039/c5ce00489f
PG 4
WC Chemistry, Multidisciplinary; Crystallography
SC Chemistry; Crystallography
GA CJ4UF
UT WOS:000355481800005
ER
PT J
AU Gill, HS
Thota, S
Li, L
Kokil, A
Mosurkal, R
Kumar, J
AF Gill, Hardeep Singh
Thota, Sammaiah
Li, Lian
Kokil, Akshay
Mosurkal, Ravi
Kumar, Jayant
TI Performance enhancement of fullerene based solar cells upon NIR laser
irradiation
SO RSC ADVANCES
LA English
DT Article
ID FILMS; POLY(3-HEXYLTHIOPHENE); P3HT/PCBM; C-60; POLYMERIZATION;
NANOPARTICLES; MORPHOLOGY; EFFICIENT; ACCEPTOR; DONOR
AB Photovoltaic performance enhancement of fullerene based solar cells was achieved upon exposure to near-infrared (NIR) laser pulses. The solar cells were fabricated with poly(3-hexylthiophene) (P3HT) and [6,6]-phenyl C-61-butyric acid methyl ester (PCBM) under ambient conditions. The cells were then post-treated with NIR femto-second laser pulses at 800 nm for different intervals of time. An enhancement of 50% in the power conversion efficiency was achieved for the devices with 15 minutes of NIR laser irradiation compared to that of the control device. The enhancement in the power conversion efficiency is attributed to the formation of a covalent linkage between P3HT and PCBM as suggested by Matrix-assisted laser desorption/ionization time of flight mass spectroscopic analysis on a blend of a thiophene oligomer and PCBM before and after NIR laser exposure.
C1 [Gill, Hardeep Singh; Kumar, Jayant] Univ Massachusetts Lowell, Dept Phys, Lowell, MA 01854 USA.
[Gill, Hardeep Singh; Thota, Sammaiah; Kokil, Akshay; Kumar, Jayant] Univ Massachusetts Lowell, Ctr Adv Mat, Lowell, MA 01854 USA.
[Li, Lian; Mosurkal, Ravi] US Army, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA.
RP Kumar, J (reprint author), Univ Massachusetts Lowell, Dept Phys, Lowell, MA 01854 USA.
EM Lian_Li@uml.edu; Jayant_Kumar@uml.edu
RI MOSURKAL, RAVI/P-6981-2015
FU Polymer-Based Materials for Harvesting Solar Energy, an Energy Frontier
Research Center - U.S. Department of Energy, Office of Science, Basic
Energy Sciences [DE-SC0001087]; Faculty Research Participation Program
at the U.S. Army Natick Soldier Research, Development and Engineering
Center (NSRDEC)
FX This work was supported as part of Polymer-Based Materials for
Harvesting Solar Energy, an Energy Frontier Research Center funded by
the U.S. Department of Energy, Office of Science, Basic Energy Sciences
under Award #DE-SC0001087. This research was also supported by in part
by an appointment to the Faculty Research Participation Program at the
U.S. Army Natick Soldier Research, Development and Engineering Center
(NSRDEC) administered by the Oak Ridge Institute for Science and
Education through an interagency agreement between the U.S. Department
of Energy and NSRDEC.
NR 29
TC 1
Z9 1
U1 3
U2 5
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 2046-2069
J9 RSC ADV
JI RSC Adv.
PY 2015
VL 5
IS 60
BP 48526
EP 48532
DI 10.1039/c5ra05640c
PG 7
WC Chemistry, Multidisciplinary
SC Chemistry
GA CJ8GN
UT WOS:000355738300044
ER
PT S
AU Esola, S
Bartoli, I
Horner, SE
Zheng, JQ
Kontsos, A
AF Esola, S.
Bartoli, I.
Horner, S. E.
Zheng, J. Q.
Kontsos, A.
BE Chimenti, DE
Bond, LJ
TI Parametric Study Using Modal Analysis of a Bi-Material Plate with
Defects
SO 41ST ANNUAL REVIEW OF PROGRESS IN QUANTITATIVE NONDESTRUCTIVE
EVALUATION, VOL 34
SE AIP Conference Proceedings
LA English
DT Proceedings Paper
CT 41st Annual Review of Progress in Quantitative Nondestructive Evaluation
(QNDE)
CY JUL 20-25, 2014
CL Boise, ID
SP Ctr Nondestruct Evaluat, Quantitat Nondestruct Evaluat Programs, Amer Soc Nondestruct Testing, World Federat NDE Ctr, Natl Sci Fdn, Ind Univ Co Operat Res Ctr Program
ID RECTANGULAR-PLATES; FREE VIBRATION; COMPOSITE; DELAMINATION; DAMAGE
AB Global vibrational method feasibility as a non-destructive inspection tool for multi-layered composites is evaluated using a simulated parametric study approach. A finite element model of a composite consisting of two, isotropic layers of dissimilar materials and a third, thin isotropic layer of adhesive is constructed as the representative test subject. Next, artificial damage is inserted according to systematic variations of the defect morphology parameters. A free-vibrational modal analysis simulation is executed for pristine and damaged plate conditions. Finally, resultant mode shapes and natural frequencies are extracted, compared and analyzed for trends. Though other defect types may be explored, the focus of this research is on interfacial delamination and its effects on the global, free-vibrational behavior of a composite plate. This study is part of a multi-year research effort conducted for the U. S. Army Program Executive Office - Soldier.
C1 [Esola, S.; Kontsos, A.] Drexel Univ, Dept Mech Engn & Mech, Theoret & Appl Mech Grp, Philadelphia, PA 19104 USA.
[Bartoli, I.] Drexel Univ, Dept Civil Architectural & Environm Engn, Philadelphia, PA 19104 USA.
[Horner, S. E.; Zheng, J. Q.] US Army, Program Execut Off Soldier, Ft Belvoir, VA 22060 USA.
RP Kontsos, A (reprint author), Drexel Univ, Dept Mech Engn & Mech, Theoret & Appl Mech Grp, 3141 Chestnut St, Philadelphia, PA 19104 USA.
EM akontsos@coe.drexel.edu
NR 17
TC 0
Z9 0
U1 0
U2 0
PU AMER INST PHYSICS
PI MELVILLE
PA 2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA
SN 0094-243X
BN 978-0-7354-1292-7
J9 AIP CONF PROC
PY 2015
VL 1650
BP 1112
EP 1120
DI 10.1063/1.4914720
PG 9
WC Physics, Applied
SC Physics
GA BC7JI
UT WOS:000354938100131
ER
PT B
AU Plaisant, C
Monroe, M
Meyer, T
Shneiderman, B
AF Plaisant, Catherine
Monroe, Megan
Meyer, Tamra
Shneiderman, Ben
BE Marconi, K
Lehmann, H
TI Interactive Visualization
SO BIG DATA AND HEALTH ANALYTICS
LA English
DT Article; Book Chapter
AB This chapter focuses on the central role of information visualization in health analytics. From the early x-rays to 3D volume visualizations, rapid progress has been made. However, the most exciting growth is now in the area of information visualization, which offers interactive environments and analytic processes that help support exploration of electronic health record (EHR) data, monitoring, or insight discovery. For example, a health organization might want to investigate patterns of drug prescriptions in patients with asthma and compare prescribing practices with current guidelines. Temporal patterns are critical to this analysis, and interactive visualizations are beginning to support powerful temporal queries, present rich result summaries, and offer fluid interactions to identify the clinically relevant patterns hidden in the data. Visualization should soon help clinicians identify cohorts of patients who match selection criteria for clinical trials or need to be brought back to the office. Visualization can also reveal data quality problems, which are common when repurposing clinical data for secondary analysis. After a quick summary of the state-of-the-art of information visualization systems for exploring and querying EHR data, we describe in detail one recent system (EventFlow) developed by the Human-Computer Interaction Lab at the University of Maryland and illustrate its use with an asthma prescription study example.
C1 [Plaisant, Catherine; Shneiderman, Ben] Univ Maryland, Inst Adv Comp Studies, Human Comp Interact Lab, College Pk, MD 20742 USA.
[Monroe, Megan] Univ Maryland, Inst Adv Comp Studies, College Pk, MD 20742 USA.
[Meyer, Tamra] US Army, Off Surgeon Gen, Washington, DC 20310 USA.
RP Plaisant, C (reprint author), Univ Maryland, Inst Adv Comp Studies, Human Comp Interact Lab, College Pk, MD 20742 USA.
NR 20
TC 0
Z9 0
U1 0
U2 1
PU CRC PRESS-TAYLOR & FRANCIS GROUP
PI BOCA RATON
PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA
BN 978-1-4822-2925-7; 978-1-4822-2923-3
PY 2015
BP 243
EP 262
PG 20
WC Health Care Sciences & Services; Medical Informatics
SC Health Care Sciences & Services; Medical Informatics
GA BC5BP
UT WOS:000353153000014
ER
PT J
AU Chen, J
Carter, R
Maoz, D
Tobar, A
Sharon, E
Greif, F
AF Chen, Jacob
Carter, Robert, III
Maoz, Daniel
Tobar, Ana
Sharon, Eran
Greif, Franklin
TI Breast Cancer and Sarcoidosis: Case Series and Review of the Literature
SO BREAST CARE
LA English
DT Article
DE Sarcoidosis; Breast cancer; Sarcoid-like reaction
ID POSITRON-EMISSION-TOMOGRAPHY; PULMONARY SARCOIDOSIS; MAMMARY
SARCOIDOSIS; MIMICKING CARCINOMA; NEEDLE-ASPIRATION; MALIGNANT TUMOURS;
LYMPH-NODES; FOLLOW-UP; DIAGNOSIS; TUMORS
AB Background: Sarcoidosis is a chronic inflammatory disease of unknown etiology, which can involve different organs and systems. Accordingly, sarcoidosis can mimic breast cancer, making the differential diagnosis very difficult. Case Report: 5 patients with a diagnosis of both sarcoidosis and breast cancer followed by the Rabin Medical Center between January 1993 and June 2012 were enrolled in this study. Additionally, a comprehensive literature review which identified 104 patients diagnosed with breast cancer and sarcoidosis was carried out. In both populations reviewed, the average age at diagnosis of sarcoidosis and breast cancer was 57 years. Among the 66 patients with both sarcoidosis and breast cancer, sarcoidosis preceded breast cancer in 31 cases, followed it in 23 cases, and appeared concurrently in 10 cases. Conclusion: Based on our clinical cases and literature review, a histological study is recommended over imaging if sarcoidosis or breast cancer may be present. Furthermore, breast cancer is rarely associated with sarcoidosis or sarcoidosis-like reaction.
C1 [Chen, Jacob; Maoz, Daniel; Sharon, Eran; Greif, Franklin] Rabin Med Ctr, Dept Surg, IL-49100 Petah Tiqwa, Israel.
[Chen, Jacob; Maoz, Daniel; Tobar, Ana; Sharon, Eran; Greif, Franklin] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel.
[Chen, Jacob; Carter, Robert, III] US Army Inst Surg Res, Houston, TX USA.
[Tobar, Ana] Rabin Med Ctr, Dept Pathol, IL-49100 Petah Tiqwa, Israel.
RP Greif, F (reprint author), Rabin Med Ctr, Dept Surg A, Beilinson Campus 39 Jabotinsky St, IL-49100 Petah Tiqwa, Israel.
EM fgreif@clalit.org.il
NR 65
TC 0
Z9 0
U1 0
U2 1
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1661-3791
EI 1661-3805
J9 BREAST CARE
JI Breast Care
PY 2015
VL 10
IS 2
BP 137
EP 140
DI 10.1159/000381324
PG 4
WC Oncology; Obstetrics & Gynecology
SC Oncology; Obstetrics & Gynecology
GA CI8IG
UT WOS:000355015300010
PM 26195943
ER
PT B
AU Wick, CH
AF Wick, Charles H.
BA Wick, CH
BF Wick, CH
TI Detection of Whole Viruses
SO INTEGRATED VIRUS DETECTION
LA English
DT Article; Book Chapter
C1 [Wick, Charles H.] US Army Edgewood Chem Biol Ctr ECBC, Aberdeen Proving Ground, MD USA.
[Wick, Charles H.] US Army Ballist Res Lab, Vulnerabil Lethal Div, Warsaw, Poland.
[Wick, Charles H.] US Army, Washington, DC USA.
[Wick, Charles H.] Biol Def Syst, Washington, DC USA.
[Wick, Charles H.] ECBC, DoD, Washington, DC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU CRC PRESS-TAYLOR & FRANCIS GROUP
PI BOCA RATON
PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA
BN 978-1-4822-3007-9; 978-1-4822-3005-5
PY 2015
BP 1
EP 29
PG 29
WC Infectious Diseases; Virology
SC Infectious Diseases; Virology
GA BC7NC
UT WOS:000355008300002
ER
PT B
AU Wick, CH
AF Wick, Charles H.
BA Wick, CH
BF Wick, CH
TI Integrated Virus Detection Preface
SO INTEGRATED VIRUS DETECTION
LA English
DT Article; Book Chapter
ID FLIGHT MASS-SPECTROMETRY; DETECTION SYSTEM IVDS; MS2 BACTERIOPHAGE;
ESCHERICHIA-COLI; MOLECULAR-WEIGHT; PROTEIN; IDENTIFICATION;
PURIFICATION
C1 [Wick, Charles H.] US Army Edgewood Chem Biol Ctr ECBC, Aberdeen Proving Ground, MD USA.
[Wick, Charles H.] US Army Ballist Res Lab, Vulnerabil Lethal Div, Warsaw, Poland.
[Wick, Charles H.] US Army, Washington, DC USA.
[Wick, Charles H.] Biol Def Syst, Washington, DC USA.
[Wick, Charles H.] ECBC, DoD, Washington, DC USA.
NR 60
TC 0
Z9 0
U1 0
U2 0
PU CRC PRESS-TAYLOR & FRANCIS GROUP
PI BOCA RATON
PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA
BN 978-1-4822-3007-9; 978-1-4822-3005-5
PY 2015
BP XVII
EP +
PG 5
WC Infectious Diseases; Virology
SC Infectious Diseases; Virology
GA BC7NC
UT WOS:000355008300001
ER
PT B
AU Wick, CH
AF Wick, Charles H.
BA Wick, CH
BF Wick, CH
TI Instrumentation
SO INTEGRATED VIRUS DETECTION
LA English
DT Article; Book Chapter
C1 [Wick, Charles H.] US Army Edgewood Chem Biol Ctr ECBC, Aberdeen Proving Ground, MD USA.
[Wick, Charles H.] US Army Ballist Res Lab, Vulnerabil Lethal Div, Warsaw, Poland.
[Wick, Charles H.] US Army, Washington, DC USA.
[Wick, Charles H.] Biol Def Syst, Washington, DC USA.
[Wick, Charles H.] ECBC, DoD, Washington, DC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU CRC PRESS-TAYLOR & FRANCIS GROUP
PI BOCA RATON
PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA
BN 978-1-4822-3007-9; 978-1-4822-3005-5
PY 2015
BP 31
EP 70
PG 40
WC Infectious Diseases; Virology
SC Infectious Diseases; Virology
GA BC7NC
UT WOS:000355008300003
ER
PT B
AU Wick, CH
AF Wick, Charles H.
BA Wick, CH
BF Wick, CH
TI Proof Concept Using MS2
SO INTEGRATED VIRUS DETECTION
LA English
DT Article; Book Chapter
C1 [Wick, Charles H.] US Army Edgewood Chem Biol Ctr ECBC, Aberdeen Proving Ground, MD USA.
[Wick, Charles H.] US Army Ballist Res Lab, Vulnerabil Lethal Div, Warsaw, Poland.
[Wick, Charles H.] US Army, Washington, DC USA.
[Wick, Charles H.] Biol Def Syst, Washington, DC USA.
[Wick, Charles H.] ECBC, DoD, Washington, DC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU CRC PRESS-TAYLOR & FRANCIS GROUP
PI BOCA RATON
PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA
BN 978-1-4822-3007-9; 978-1-4822-3005-5
PY 2015
BP 71
EP 96
PG 26
WC Infectious Diseases; Virology
SC Infectious Diseases; Virology
GA BC7NC
UT WOS:000355008300004
ER
PT B
AU Wick, CH
AF Wick, Charles H.
BA Wick, CH
BF Wick, CH
TI Concentration of Viruses
SO INTEGRATED VIRUS DETECTION
LA English
DT Article; Book Chapter
C1 [Wick, Charles H.] US Army Edgewood Chem Biol Ctr ECBC, Aberdeen Proving Ground, MD USA.
[Wick, Charles H.] US Army Ballist Res Lab, Vulnerabil Lethal Div, Warsaw, Poland.
[Wick, Charles H.] US Army, Washington, DC USA.
[Wick, Charles H.] Biol Def Syst, Washington, DC USA.
[Wick, Charles H.] ECBC, DoD, Washington, DC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU CRC PRESS-TAYLOR & FRANCIS GROUP
PI BOCA RATON
PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA
BN 978-1-4822-3007-9; 978-1-4822-3005-5
PY 2015
BP 97
EP 106
PG 10
WC Infectious Diseases; Virology
SC Infectious Diseases; Virology
GA BC7NC
UT WOS:000355008300005
ER
PT B
AU Wick, CH
AF Wick, Charles H.
BA Wick, CH
BF Wick, CH
TI Cause and Effect Curves
SO INTEGRATED VIRUS DETECTION
LA English
DT Article; Book Chapter
C1 [Wick, Charles H.] US Army Edgewood Chem Biol Ctr ECBC, Aberdeen Proving Ground, MD USA.
[Wick, Charles H.] US Army Ballist Res Lab, Vulnerabil Lethal Div, Warsaw, Poland.
[Wick, Charles H.] US Army, Washington, DC USA.
[Wick, Charles H.] Biol Def Syst, Washington, DC USA.
[Wick, Charles H.] ECBC, DoD, Washington, DC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU CRC PRESS-TAYLOR & FRANCIS GROUP
PI BOCA RATON
PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA
BN 978-1-4822-3007-9; 978-1-4822-3005-5
PY 2015
BP 107
EP 120
PG 14
WC Infectious Diseases; Virology
SC Infectious Diseases; Virology
GA BC7NC
UT WOS:000355008300006
ER
PT B
AU Wick, CH
AF Wick, Charles H.
BA Wick, CH
BF Wick, CH
TI Isolating Single Viruses from Multivirus Mixtures
SO INTEGRATED VIRUS DETECTION
LA English
DT Article; Book Chapter
C1 [Wick, Charles H.] US Army Edgewood Chem Biol Ctr ECBC, Aberdeen Proving Ground, MD USA.
[Wick, Charles H.] US Army Ballist Res Lab, Vulnerabil Lethal Div, Warsaw, Poland.
[Wick, Charles H.] US Army, Washington, DC USA.
[Wick, Charles H.] Biol Def Syst, Washington, DC USA.
[Wick, Charles H.] ECBC, DoD, Washington, DC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU CRC PRESS-TAYLOR & FRANCIS GROUP
PI BOCA RATON
PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA
BN 978-1-4822-3007-9; 978-1-4822-3005-5
PY 2015
BP 121
EP 129
PG 9
WC Infectious Diseases; Virology
SC Infectious Diseases; Virology
GA BC7NC
UT WOS:000355008300007
ER
PT B
AU Wick, CH
AF Wick, Charles H.
BA Wick, CH
BF Wick, CH
TI Analyzing Various Viruses
SO INTEGRATED VIRUS DETECTION
LA English
DT Article; Book Chapter
C1 [Wick, Charles H.] US Army Edgewood Chem Biol Ctr ECBC, Aberdeen Proving Ground, MD USA.
[Wick, Charles H.] US Army Ballist Res Lab, Vulnerabil Lethal Div, Warsaw, Poland.
[Wick, Charles H.] US Army, Washington, DC USA.
[Wick, Charles H.] Biol Def Syst, Washington, DC USA.
[Wick, Charles H.] ECBC, DoD, Washington, DC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU CRC PRESS-TAYLOR & FRANCIS GROUP
PI BOCA RATON
PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA
BN 978-1-4822-3007-9; 978-1-4822-3005-5
PY 2015
BP 131
EP 163
PG 33
WC Infectious Diseases; Virology
SC Infectious Diseases; Virology
GA BC7NC
UT WOS:000355008300008
ER
PT B
AU Wick, CH
AF Wick, Charles H.
BA Wick, CH
BF Wick, CH
TI Detection of Other Nanoparticles
SO INTEGRATED VIRUS DETECTION
LA English
DT Article; Book Chapter
C1 [Wick, Charles H.] US Army Edgewood Chem Biol Ctr ECBC, Aberdeen Proving Ground, MD USA.
[Wick, Charles H.] US Army Ballist Res Lab, Vulnerabil Lethal Div, Warsaw, Poland.
[Wick, Charles H.] US Army, Washington, DC USA.
[Wick, Charles H.] Biol Def Syst, Washington, DC USA.
[Wick, Charles H.] ECBC, DoD, Washington, DC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU CRC PRESS-TAYLOR & FRANCIS GROUP
PI BOCA RATON
PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA
BN 978-1-4822-3007-9; 978-1-4822-3005-5
PY 2015
BP 165
EP 173
PG 9
WC Infectious Diseases; Virology
SC Infectious Diseases; Virology
GA BC7NC
UT WOS:000355008300009
ER
PT B
AU Wick, CH
AF Wick, Charles H.
BA Wick, CH
BF Wick, CH
TI Direct Counting of Pili
SO INTEGRATED VIRUS DETECTION
LA English
DT Article; Book Chapter
C1 [Wick, Charles H.] US Army Edgewood Chem Biol Ctr ECBC, Aberdeen Proving Ground, MD USA.
[Wick, Charles H.] US Army Ballist Res Lab, Vulnerabil Lethal Div, Warsaw, Poland.
[Wick, Charles H.] US Army, Washington, DC USA.
[Wick, Charles H.] Biol Def Syst, Washington, DC USA.
[Wick, Charles H.] ECBC, DoD, Washington, DC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU CRC PRESS-TAYLOR & FRANCIS GROUP
PI BOCA RATON
PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA
BN 978-1-4822-3007-9; 978-1-4822-3005-5
PY 2015
BP 175
EP 183
PG 9
WC Infectious Diseases; Virology
SC Infectious Diseases; Virology
GA BC7NC
UT WOS:000355008300010
ER
PT B
AU Wick, CH
AF Wick, Charles H.
BA Wick, CH
BF Wick, CH
TI Detecting Viruses in Honeybees
SO INTEGRATED VIRUS DETECTION
LA English
DT Article; Book Chapter
C1 [Wick, Charles H.] US Army Edgewood Chem Biol Ctr ECBC, Aberdeen Proving Ground, MD USA.
[Wick, Charles H.] US Army Ballist Res Lab, Vulnerabil Lethal Div, Warsaw, Poland.
[Wick, Charles H.] US Army, Washington, DC USA.
[Wick, Charles H.] Biol Def Syst, Washington, DC USA.
[Wick, Charles H.] ECBC, DoD, Washington, DC USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU CRC PRESS-TAYLOR & FRANCIS GROUP
PI BOCA RATON
PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA
BN 978-1-4822-3007-9; 978-1-4822-3005-5
PY 2015
BP 185
EP 205
PG 21
WC Infectious Diseases; Virology
SC Infectious Diseases; Virology
GA BC7NC
UT WOS:000355008300011
ER
PT B
AU Wick, CH
AF Wick, Charles H.
BA Wick, CH
BF Wick, CH
TI Pulsed Lamp Decontamination
SO INTEGRATED VIRUS DETECTION
LA English
DT Article; Book Chapter
C1 [Wick, Charles H.] US Army Edgewood Chem Biol Ctr ECBC, Aberdeen Proving Ground, MD USA.
[Wick, Charles H.] US Army Ballist Res Lab, Vulnerabil Lethal Div, Warsaw, Poland.
[Wick, Charles H.] US Army, Washington, DC USA.
[Wick, Charles H.] Biol Def Syst, Washington, DC USA.
[Wick, Charles H.] ECBC, DoD, Washington, DC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU CRC PRESS-TAYLOR & FRANCIS GROUP
PI BOCA RATON
PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA
BN 978-1-4822-3007-9; 978-1-4822-3005-5
PY 2015
BP 207
EP 219
PG 13
WC Infectious Diseases; Virology
SC Infectious Diseases; Virology
GA BC7NC
UT WOS:000355008300012
ER
PT B
AU Wick, CH
AF Wick, Charles H.
BA Wick, CH
BF Wick, CH
TI Current and Future Trends
SO INTEGRATED VIRUS DETECTION
LA English
DT Article; Book Chapter
C1 [Wick, Charles H.] US Army Edgewood Chem Biol Ctr ECBC, Aberdeen Proving Ground, MD USA.
[Wick, Charles H.] US Army Ballist Res Lab, Vulnerabil Lethal Div, Warsaw, Poland.
[Wick, Charles H.] US Army, Washington, DC USA.
[Wick, Charles H.] Biol Def Syst, Washington, DC USA.
[Wick, Charles H.] ECBC, DoD, Washington, DC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU CRC PRESS-TAYLOR & FRANCIS GROUP
PI BOCA RATON
PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA
BN 978-1-4822-3007-9; 978-1-4822-3005-5
PY 2015
BP 221
EP 224
PG 4
WC Infectious Diseases; Virology
SC Infectious Diseases; Virology
GA BC7NC
UT WOS:000355008300013
ER
PT J
AU Hurley, RK
Rivera, JC
Wenke, JC
Krueger, CA
AF Hurley, Richard K., Jr.
Rivera, Jessica C.
Wenke, Joseph C.
Krueger, Chad A.
TI Identifying obstacles to return to duty in severely injured
combat-related servicemembers with amputation
SO JOURNAL OF REHABILITATION RESEARCH AND DEVELOPMENT
LA English
DT Article
DE Active Duty; amputation; combat; combat-related amputation; disability;
disability rating; Injury Severity Score; physician evaluation liaison
board; rehabilitation; return to duty
ID TRAUMA RECOVERY PROJECT; CURRENT CONFLICTS; AMPUTEE SOLDIERS; EXTREMITY;
PROSTHETICS; AFGHANISTAN; 12-MONTH; OUTCOMES; IRAQ; WAR
AB The capacity of servicemembers with amputation to return to duty after combat-related amputation and the associated disabilities remains largely unknown. The purpose of this study was to examine the disabling conditions and return to duty rates of servicemembers with amputation across all service branches following major limb amputations from September 2001 through July 2011. Pertinent medical information, military occupation status, return to duty designation, disabling conditions, and disability ratings for each servicemember were obtained from the Physical Evaluation Board Liaison Office (PEBLO). Across all service branches, 16 (2%) servicemembers were found fit for duty (Fit) and allowed to continue with their preinjury occupation. Another 103 (11%) were allowed to continue on Active Duty (COAD) in a less physically demanding role. More than half (554, 56%) were determined fully disabled (PEBLO rating > 75); the average disability rating was 73. COAD and Fit Army servicemembers had lower Injury Severity Scores than other servicemembers (17.4, p = 0.009 and 11.2, p < 0.001, respectively). Despite improvements in their care and rehabilitation, only 13% of all servicemembers with amputation are able to return to Active Duty and many have multiple disabling conditions that contribute to a very high level of disability.
C1 [Hurley, Richard K., Jr.] San Antonio Mil Med Ctr, Dept Orthopaed Surg, Ft Sam Houston, TX 78234 USA.
[Rivera, Jessica C.; Krueger, Chad A.] San Antonio Mil Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA.
[Wenke, Joseph C.] US Army, Inst Surg Res, Dept Regenerat Med, Ft Sam Houston, TX 78234 USA.
RP Hurley, RK (reprint author), San Antonio Mil Med Ctr, Orthopaed Surg, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM richard.k.hurley.mil@mail.mil
NR 22
TC 2
Z9 2
U1 1
U2 4
PU JOURNAL REHAB RES & DEV
PI BALTIMORE
PA DEPT OF VETERANS AFFAIRS REHABIL RES & DEVELOP CTR 103 SOUTH GAY STREET,
BALTIMORE, MD 21202-4051 USA
SN 0748-7711
EI 1938-1352
J9 J REHABIL RES DEV
JI J. Rehabil. Res. Dev.
PY 2015
VL 52
IS 1
BP 53
EP 61
DI 10.1682/JRRD.2014.04.0094
PG 9
WC Rehabilitation
SC Rehabilitation
GA CI8YI
UT WOS:000355057200006
PM 26230831
ER
PT J
AU Hohenforst-Schmidt, W
Zarogoulidis, P
Stopek, J
Vogl, T
Hubner, F
Turner, JF
Browning, R
Zarogoulidis, K
Drevelegas, A
Drevelegas, K
Darwiche, K
Freitag, L
Rittger, H
AF Hohenforst-Schmidt, Wolfgang
Zarogoulidis, Paul
Stopek, Joshua
Vogl, Thomas
Hubner, Frank
Turner, J. Francis
Browning, Robert
Zarogoulidis, Konstantinos
Drevelegas, Antonis
Drevelegas, Konstantinos
Darwiche, Kaid
Freitag, Lutz
Rittger, Harald
TI DDMC-p53 gene therapy with or without cisplatin and microwave ablation
SO ONCOTARGETS AND THERAPY
LA English
DT Article
DE DDMC; p53; carboplatin; microwave; non-small cell lung cancer
ID CELL LUNG-CANCER; GROWTH-FACTOR RECEPTOR; RADIOFREQUENCY ABLATION;
THERMAL ABLATION; INTRATUMORAL CHEMOTHERAPY; RESPIRATORY SYSTEM; AEROSOL
DELIVERY; PROSTATE-CANCER; BREAST-CANCER; IN-VITRO
AB Lung cancer remains the leading cause of death in cancer patients. Severe treatment side effects and late stage of disease at diagnosis continue to be an issue. We investigated whether local treatment using 2-diethylaminoethyl-dextran methyl methacrylate copolymer with p53 (DDMC-p53) with or without cisplatin and/or microwave ablation enhances disease control in BALBC mice. We used a Lewis lung carcinoma cell line to inoculate 140 BALBC mice, which were divided into the following seven groups; control, cisplatin, microwave ablation, DDMC-p53, DDMC-p53 plus cisplatin, DDMC-p53 plus microwave, and DDMC-p53 plus cisplatin plus microwave. Microwave ablation energy was administered at 20 W for 10 minutes. Cisplatin was administered as 1 mL/mg and the DDMC-p53 complex delivered was 0.5 mL. Increased toxicity was observed in the group receiving DDMC-p53 plus cisplatin plus microwave followed by the group receiving DDMC-p53 plus cisplatin. Infection after repeated treatment administration was a major issue. We conclude that a combination of gene therapy using DDMC-p53 with or without cisplatin and microwave is an alternative method for local disease control. However, more experiments are required in a larger model to identify the appropriate dosage profile.
C1 [Hohenforst-Schmidt, Wolfgang; Hubner, Frank] Univ Wurzburg, Coburg Hosp, Med Clin 2, Coburg, Germany.
[Zarogoulidis, Paul; Zarogoulidis, Konstantinos] Aristotle Univ Thessaloniki, Dept Pulm, Oncol Unit, G Papanikolaou Gen Hosp, GR-54006 Thessaloniki, Greece.
[Stopek, Joshua] Covidien, Jersey City, NJ USA.
[Vogl, Thomas] Goethe Univ Frankfurt, Dept Diagnost & Intervent Radiol, D-60054 Frankfurt, Germany.
[Turner, J. Francis] Western Reg Med Ctr, Div Intervent Pulmonol, Goodyear, AZ USA.
[Turner, J. Francis] Western Reg Med Ctr, Med Oncol, Canc Treatment Ctr Amer, Goodyear, AZ USA.
[Browning, Robert] Walter Reed Army Med Ctr, Pulm & Crit Care Med, Intervent Pulmonol, Natl Naval Med Ctr, Bethesda, MD USA.
[Drevelegas, Antonis; Drevelegas, Konstantinos] Interbalkan European Med Ctr, Dept Radiol, Thessaloniki, Greece.
[Darwiche, Kaid; Freitag, Lutz] Univ Essen Duisburg, Univ Hosp Essen, Ruhrlandklin, Dept Intervent Pneumol, Essen, Germany.
[Rittger, Harald] Univ Erlangen Nurnberg, Fuerth Hosp, Med Clin 1, Erlangen, Germany.
RP Zarogoulidis, P (reprint author), Aristotle Univ Thessaloniki, Dept Pulm, Oncol Unit, G Papanikolaou Gen Hosp, GR-54006 Thessaloniki, Greece.
EM pzarog@hotmail.com
NR 83
TC 1
Z9 1
U1 2
U2 9
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-6930
J9 ONCOTARGETS THER
JI OncoTargets Ther.
PY 2015
VL 8
BP 1165
EP 1173
DI 10.2147/OTT.S83794
PG 9
WC Biotechnology & Applied Microbiology; Oncology
SC Biotechnology & Applied Microbiology; Oncology
GA CI5HE
UT WOS:000354784700001
PM 26056480
ER
PT J
AU Bynum, JA
Rastogi, A
Stavchansky, SA
Bowman, PD
AF Bynum, James A.
Rastogi, Ashish
Stavchansky, Salomon A.
Bowman, Phillip D.
TI Cytoprotection of Human Endothelial Cells from Oxidant Stress with CDDO
Derivatives: Network Analysis of Genes Responsible for Cytoprotection
SO PHARMACOLOGY
LA English
DT Article
DE Cytoprotection; Human endothelial cells; CDDO-Im; CDDO-Me; Gene
expression profiling; Oxidant stress
ID ACID PHENETHYL ESTER; POTENT COMPETITIVE INHIBITOR; TIN
PROTOPORPHYRIN-IX; HEME OXYGENASE-1; OXIDATIVE STRESS;
2-CYANO-3,12-DIOXOOLEAN-1,9-DIEN-28-OIC ACID; INFLAMMATORY RESPONSE;
SYSTEMS PHARMACOLOGY; SPECIES GENERATION; MOUSE MACROPHAGES
AB Aim:To identify drugs that may reduce the impact of oxidant stress on cell viability. Methods: Human umbilical vein endothelial cells were treated with 200 nmol/ICDDO-Im (imidazole) and CDDO-Me (methyl) after exposure to menadione and compared to vehicle-treated cells. Cell viability and cytotoxicity were assessed, and gene expression profiling was performed. Results: CDDO-Im was significantly more cytoprotective and less cytotoxic (p < 0.001) than CDDO-Me. Although both provided cytoprotection by induction of gene transcription, CDDO-lm induced more genes. In addition to a higher induction of the key cytoprotective gene heme oxygenase-1 (38.9-fold increase for CDDO-Im and 26.5-fold increase for CDDO-Me), CDDO-Im also induced greater expression of heat shock proteins (5.5-fold increase compared to 2.8-fold for CDDO-Me). Conclusions: Both compounds showed good induction of heme oxygenase, which largely accounted for their cytoprotective effect. Differences were detected in cytotoxicity at higher doses, indicating that CDDO-Me was more cytotoxic than CDDO-Im. Significant differences were detected in the ability of CDDO-Im and CDDO-Me to affect differential gene transcription. CDDO-Im induced more genes than did CDDO-Me. The source of the differences in gene expression patterns between CDDO-Im and CDDO-Me was not determined but may be important in long-term use of this class of drugs. (C) 2015 S. Karger AG, Basel
C1 [Bynum, James A.; Rastogi, Ashish; Bowman, Phillip D.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Bynum, James A.; Rastogi, Ashish; Stavchansky, Salomon A.] Univ Texas Austin, Coll Pharm, Div Pharmaceut, Austin, TX 78712 USA.
RP Bowman, PD (reprint author), US Army, Inst Surg Res, 3650 Chambers Pass, Ft Sam Houston, TX 78234 USA.
EM phillip.d.bowman4.vol@mail.mil
NR 63
TC 1
Z9 1
U1 0
U2 1
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0031-7012
EI 1423-0313
J9 PHARMACOLOGY
JI Pharmacology
PY 2015
VL 95
IS 3-4
BP 181
EP 192
DI 10.1159/000381188
PG 12
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA CI3QX
UT WOS:000354663600011
PM 25926128
ER
PT J
AU Hohenforst-Schmidt, W
Linsmeier, B
Zarogoulidis, P
Freitag, L
Darwiche, K
Browning, R
Turner, JF
Huang, HD
Li, Q
Vogl, T
Zarogoulidis, K
Brachmann, J
Rittger, H
AF Hohenforst-Schmidt, Wolfgang
Linsmeier, Bernd
Zarogoulidis, Paul
Freitag, Lutz
Darwiche, Kaid
Browning, Robert
Turner, J. Francis
Huang, Haidong
Li, Qiang
Vogl, Thomas
Zarogoulidis, Konstantinos
Brachmann, Johannes
Rittger, Harald
TI Transtracheal single-point stent fixation in posttracheotomy
tracheomalacia under cone-beam computer tomography guidance by
transmural suturing with the Berci needle - a perspective on a new tool
to avoid stent migration of Dumon stents
SO THERAPEUTICS AND CLINICAL RISK MANAGEMENT
LA English
DT Article
DE stent; airway; cone-beam computer tomography; Berci needle; Dumon
stents; tracheobronchomalacia
ID BENIGN TRACHEOBRONCHIAL STENOSIS; POSITIVE AIRWAY PRESSURE; ELUTING
TRACHEAL STENT; SILICONE STENTS; EXTERNAL FIXATION; COLLAPSE;
STABILIZATION; OBSTRUCTION; OUTCOMES; ADULT
AB Tracheomalacia or tracheobronchomalacia (TM or TBM) is a common problem especially for elderly patients often unfit for surgical techniques. Several surgical or minimally invasive techniques have already been described. Stenting is one option but in general long-time stenting is accompanied by a high complication rate. Stent removal is more difficult in case of self-expandable nitinol stents or metallic stents in general in comparison to silicone stents. The main disadvantage of silicone stents in comparison to uncovered metallic stents is migration and plugging. We compared the operation time and in particular the duration of a sufficient Dumon stent fixation with different techniques in a patient with severe posttracheotomy TM and strongly reduced mobility of the vocal cords due to Parkinson's disease. The combined approach with simultaneous Dumon stenting and endoluminal transtracheal externalized suture under cone-beam computer tomography guidance with the Berci needle was by far the fastest approach compared to a (not performed) surgical intervention, or even purely endoluminal suturing through the rigid bronchoscope. The duration of the endoluminal transtracheal externalized suture was between 5 minutes and 9 minutes with the Berci needle; the pure endoluminal approach needed 51 minutes. The alternative of tracheobronchoplasty was refused by the patient. In general, 180 minutes for this surgical approach is calculated. The costs of the different approaches are supposed to vary widely due to the fact that in Germany 1 minute in an operation room costs on average approximately 50-60(sic) inclusive of taxes. In our own hospital (tertiary level), it is nearly 30(sic) per minute in an operation room for a surgical approach. Calculating an additional 15 minutes for patient preparation and transfer to wake-up room, therefore a total duration inside the investigation room of 30 minutes, the cost per flexible bronchoscopy is per minute on average less than 6(sic). Although the Dumon stenting requires a set-up with more expensive anesthesiology accompaniment, which takes longer than a flexible investigation estimated at 1 hour in an operation room, still without calculation of the costs of the materials and specialized staff that the surgical approach would consume at least 3,000(sic) more than a minimally invasive approach performed with the Berci needle. This difference is due to the longer time of the surgical intervention which is calculated at approximately 180 minutes in comparison to the achieved non-surgical approach of 60 minutes in the operation suite.
C1 [Hohenforst-Schmidt, Wolfgang; Rittger, Harald] Univ Erlangen Nurnberg, Fuerth Hosp, Med Clin 1, Furth, Germany.
[Linsmeier, Bernd] Medinos Clin Sonneberg, Dept Thorac Surg, Sonnerberg, Germany.
[Zarogoulidis, Paul; Zarogoulidis, Konstantinos] Aristotle Univ Thessaloniki, G Papanikolaou Gen Hosp, Dept Pulm, Oncol Unit, GR-54006 Thessaloniki, Greece.
[Freitag, Lutz; Darwiche, Kaid] Univ Essen Duisburg, Univ Hosp Essen, Ruhrlandklin, Dept Intervent Pneumol, Essen, Germany.
[Browning, Robert] Walter Reed Army Med Ctr, Natl Naval Med Ctr, Intervent Pulmonol, Pulm & Crit Care Med, Bethesda, MD USA.
[Turner, J. Francis] Western Reg Med Ctr, Canc Treatment Ctr Amer, Div Intervent Pulmonol & Med Oncol, Goodyear, AZ USA.
[Huang, Haidong; Li, Qiang] II Mil Univ Hosp, Shanghai Hosp, Dept Resp Dis, Shanghai, Peoples R China.
[Vogl, Thomas] Goethe Univ Frankfurt, Dept Diagnost & Intervent Radiol, D-60054 Frankfurt, Germany.
[Hohenforst-Schmidt, Wolfgang; Brachmann, Johannes] Univ Wurzburg, Coburg Hosp, Med Clin 2, Coburg, Germany.
RP Zarogoulidis, P (reprint author), Aristotle Univ Thessaloniki, G Papanikolaou Gen Hosp, Dept Pulm, Oncol Unit, GR-54006 Thessaloniki, Greece.
EM pzarog@hotmail.com
FU Siemens, Germany
FX Dr Wolfgang Hohenforst-Schmidt would like to thank Mr Carl Reiner for
providing the Model Twinstream jet ventilator. Moreover Dr Wolfgang
Hohenforst-Schmidt would like to thank Siemens, Germany for the
technical and financial support that they have provided for this
project.
NR 50
TC 3
Z9 4
U1 0
U2 4
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-203X
J9 THER CLIN RISK MANAG
JI Therap. Clin. Risk Manag.
PY 2015
VL 11
BP 837
EP 850
DI 10.2147/TCRM.S83230
PG 14
WC Health Care Sciences & Services
SC Health Care Sciences & Services
GA CI8CR
UT WOS:000354995900001
PM 26045666
ER
PT J
AU Dugan, HA
Doran, PT
Wagner, B
Kenig, F
Fritsen, CH
Arcone, SA
Kuhn, E
Ostrom, NE
Warnock, JP
Murray, AE
AF Dugan, H. A.
Doran, P. T.
Wagner, B.
Kenig, F.
Fritsen, C. H.
Arcone, S. A.
Kuhn, E.
Ostrom, N. E.
Warnock, J. P.
Murray, A. E.
TI Stratigraphy of Lake Vida, Antarctica: hydrologic implications of 27 m
of ice
SO CRYOSPHERE
LA English
DT Article
ID MCMURDO DRY VALLEYS; SOUTHERN VICTORIA LAND; TAYLOR VALLEY;
POLAR-DESERT; ISOTOPE GEOCHEMISTRY; LACUSTRINE SEDIMENTS; UNIVERSITY
VALLEY; CLIMATIC-CHANGE; GROUND ICE; HOARE
AB Lake Vida, located in Victoria Valley, is one of the largest lakes in the McMurdo dry valleys and is known to contain hypersaline liquid brine sealed below 16 m of freshwater ice. For the first time, Lake Vida was drilled to a depth of 27 m. Below 21 m the ice is marked by well-sorted sand layers up to 20 cm thick within a matrix of salty ice. From ice chemistry, isotopic composition of delta O-18 and delta H-2, and ground penetrating radar profiles, we conclude that the entire 27 m of ice formed from surface runoff and the sediment layers represent the accumulation of surface deposits. Radiocarbon and optically stimulated luminescence dating limit the maximum age of the lower ice to 6300 C-14 yr BP. As the ice cover ablated downwards during periods of low surface inflow, progressive accumulation of sediment layers insulated and preserved the ice and brine beneath, analogous to the processes that preserve shallow ground ice. The repetition of these sediment layers reveals hydrologic variability in Victoria Valley during the mid-to late Holocene. Lake Vida is an exemplar site for understanding the preservation of subsurface brine, ice, and sediment in a cold desert environment.
C1 [Dugan, H. A.; Doran, P. T.; Kenig, F.] Univ Illinois, Dept Earth & Environm Sci, Chicago, IL 60607 USA.
[Dugan, H. A.] Univ Wisconsin, Ctr Limnol, Madison, WI 53706 USA.
[Wagner, B.] Univ Cologne, Inst Geol & Mineral, D-50931 Cologne, Germany.
[Fritsen, C. H.; Kuhn, E.; Murray, A. E.] Univ Nevada, Desert Res Inst, Div Earth & Ecosyst Sci, Reno, NV 89506 USA.
[Arcone, S. A.] US Army, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA.
[Ostrom, N. E.] Michigan State Univ, Dept Zool, E Lansing, MI 48824 USA.
[Warnock, J. P.] No Illinois Univ, Dept Geol & Environm Geosci, De Kalb, IL USA.
RP Dugan, HA (reprint author), Univ Illinois, Dept Earth & Environm Sci, Chicago, IL 60607 USA.
EM hilarydugan@gmail.com
RI Wagner, Bernd/J-4682-2012;
OI Kenig, Fabien/0000-0003-4868-5232
FU National Science Foundation [0739698, 0739681]; NASA [NNX10AN23H];
Natural Sciences and Engineering Research Council of Canada; University
of Illinois at Chicago; Desert Research Institute Division of Earth and
Ecosystem Sciences; Fulbright CAPES-Brazil [2163-08-8]
FX This research was supported by National Science Foundation grants
0739698 and 0739681 and NASA grant NNX10AN23H. We would like to thank
field team members Peter Glenday, Jay Kyne, Seth Young, and Brian Glazer
and the RPSC Field Safety and Training Program, the United States
Antarctic Program, and PHI helicopters. Graduate student funding to H.
Dugan was assisted by the Natural Sciences and Engineering Research
Council of Canada and the University of Illinois at Chicago. Graduate
student funding to E. Kuhn was supported by the Desert Research
Institute Division of Earth and Ecosystem Sciences and the Fulbright
CAPES-Brazil grant 2163-08-8. Two anonymous reviewers significantly
improved this paper.
NR 68
TC 6
Z9 6
U1 1
U2 11
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1994-0416
EI 1994-0424
J9 CRYOSPHERE
JI Cryosphere
PY 2015
VL 9
IS 2
BP 439
EP 450
DI 10.5194/tc-9-439-2015
PG 12
WC Geography, Physical; Geosciences, Multidisciplinary
SC Physical Geography; Geology
GA CH2TU
UT WOS:000353878400002
ER
PT S
AU Friebele, EJ
Baker, CC
Askins, CG
Fontana, JP
Hunt, MP
Peele, JR
Marcheschi, BA
Oh, E
Kim, W
Sanghera, J
Zhang, J
Pattnaik, RK
Merkle, LD
Dubinskii, M
AF Friebele, E. Joseph
Baker, Colin C.
Askins, Charles G.
Fontana, Jake P.
Hunt, Michael P.
Peele, John R.
Marcheschi, Barbara A.
Oh, Eunkeu
Kim, Woohong
Sanghera, Jasbinder
Zhang, Jun
Pattnaik, Radha K.
Merkle, Larry D.
Dubinskii, Mark
BE Shaw, LB
Ballato, J
TI Erbium nanoparticle doped fibers for efficient, resonantly-pumped
Er-doped fiber lasers
SO FIBER LASERS XII: TECHNOLOGY, SYSTEMS, AND APPLICATIONS
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Fiber Lasers XII - Technology, Systems, and Applications
CY FEB 09-12, 2015
CL San Francisco, CA
SP SPIE, NKT Photon A S, PolarOnyx Inc
DE Erbium doped fiber; nanoparticles; high energy lasers; fiber lasers
ID SIZE; BOEHMITE; SHAPE
AB Nanoparticle (NP) doping is a new technique for making erbium-doped fibers (EDFs); the Er ions are surrounded by a cage of aluminum and oxygen ions, substantially reducing Er3+ ion-ion energy exchange and its deleterious effects on laser performance. Er-Al-doped NPs have been synthesized and doped in-situ into the silica soot of the preform core. We report the first known measurements of NP-doped EDFs in a resonantly-core pumped master oscillator-power amplifier (MOPA) configuration; the optical-to-optical slope efficiency was 80.4%, which we believe is a record for this type of fiber.
C1 [Friebele, E. Joseph; Baker, Colin C.; Askins, Charles G.; Fontana, Jake P.; Marcheschi, Barbara A.; Kim, Woohong; Sanghera, Jasbinder] Naval Res Lab, Washington, DC 20375 USA.
[Hunt, Michael P.] Univ Res Fdn, Greenbelt, MD 20770 USA.
[Peele, John R.; Oh, Eunkeu] Sotera Def Syst, Columbia, MD 21046 USA.
[Zhang, Jun; Pattnaik, Radha K.; Merkle, Larry D.; Dubinskii, Mark] Army Res Lab, Ade Iphi, MD 20783 USA.
RP Friebele, EJ (reprint author), Naval Res Lab, 4555 Overlook Ave SW, Washington, DC 20375 USA.
EM joe.friebele@ndnavy.mil
RI Baker, Colin/I-6657-2015
NR 11
TC 1
Z9 1
U1 0
U2 9
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-434-9
J9 PROC SPIE
PY 2015
VL 9344
AR 934412
DI 10.1117/12.2079443
PG 8
WC Engineering, Electrical & Electronic; Optics; Physics, Applied
SC Engineering; Optics; Physics
GA BC6EZ
UT WOS:000353887400025
ER
PT J
AU Allison, PG
Moser, RD
Chandler, MQ
Caminero-Rodriguez, JA
Torres-Cancel, K
Rivera, OG
Goodwin, JR
Gore, ER
Weiss, CA
AF Allison, P. G.
Moser, R. D.
Chandler, M. Q.
Caminero-Rodriguez, J. A.
Torres-Cancel, K.
Rivera, O. G.
Goodwin, J. R.
Gore, E. R.
Weiss, C. A., Jr.
TI Mechanical, Thermal, and Microstructural Analysis of Polyvinyl
Alcohol/Montmorillonite Nanocomposites
SO JOURNAL OF NANOMATERIALS
LA English
DT Article
ID MONTMORILLONITE NANOCOMPOSITES; POLY(VINYL ALCOHOL); SCALES; NACRE;
FILMS; CLAY; DEFORMATION; TENSILE; SHEAR; BONE
AB Structural biomaterials such as nacre, bone, and fish scales possess unique structures that have hierarchical spatial configurations, which provide excellent mechanical properties when compared to their individual constituents. These observations have been the motivation for designing and characterizing bioinspired materials with high strength, high stiffness, and corrosion-resistant properties while at the same time being environmentally friendly. It has been demonstrated that polymer-clay nanocomposites can simulate the behavior of nacreous biomaterials such as abalone shell. Mechanical, thermal, and microstructural analyses characterized solution-cast polyvinyl alcohol (PVA)/montmorillonite (MMT) nanocomposite properties over compositions ranging from the neat polymer to 25% volume fraction of MMT nanoclay. Uniaxial tensile experiments were performed at displacement rates of 1 mm/min and 50 mm/min. Strength values are similar to those shown by nacre and represent a homogeneous dispersion of the MMT in the polymer matrix. Strength-to-weight ratios are similar to many structural metals.
C1 [Allison, P. G.; Rivera, O. G.] Univ Alabama, Dept Mech Engn, Tuscaloosa, AL 35487 USA.
[Moser, R. D.; Chandler, M. Q.; Torres-Cancel, K.; Gore, E. R.; Weiss, C. A., Jr.] US Army Engn Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA.
[Caminero-Rodriguez, J. A.] Univ Puerto Rico Mayaguez, Dept Chem Engn, Mayaguez, PR 00680 USA.
[Goodwin, J. R.] Univ Alabama, Cent Analyt Facil, Tuscaloosa, AL 35487 USA.
RP Allison, PG (reprint author), Univ Alabama, Dept Mech Engn, Tuscaloosa, AL 35487 USA.
EM pallison@eng.ua.edu
FU Center-Directed Research Program, US Army Engineer Research and
Development Center
FX The authors would like to acknowledge funding provided for this work by
the Center-Directed Research Program, US Army Engineer Research and
Development Center. Permission to publish was granted by Director of
Geotechnical and Structures Laboratory.
NR 33
TC 1
Z9 1
U1 5
U2 30
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 1687-4110
EI 1687-4129
J9 J NANOMATER
JI J. Nanomater.
PY 2015
AR 291248
DI 10.1155/2015/291248
PG 9
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary
SC Science & Technology - Other Topics; Materials Science
GA CH9PC
UT WOS:000354367000001
ER
PT S
AU Shterengas, L
Liang, R
Hosoda, T
Kipshidze, G
Belenky, G
Bowman, SS
Tober, RL
AF Shterengas, L.
Liang, R.
Hosoda, T.
Kipshidze, G.
Belenky, G.
Bowman, S. S.
Tober, R. L.
BE Belyanin, AA
Smowton, PM
TI Type-I QW cascade diode lasers with 960 mW of CW power at 3 mu m.
SO NOVEL IN-PLANE SEMICONDUCTOR LASERS XIV
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Novel In-Plane Semiconductor Lasers XIV
CY FEB 09-12, 2015
CL San Francisco, CA
SP SPIE
DE diode lasers; mid-infrared; cascade pumping; type-I quantum well;
antimonides; high power
ID WAVE OUTPUT POWER
AB Cascade pumping schemes that utilize single-QW gain stages enhanced both the power conversion efficiency and the output power level of GaSb-based diode lasers that emit near and above 3 mu m at room temperature. The cascade lasers discussed in this work had densely stacked type-I QWs gain stages characterized by high differential gain. The 3 mu m emitting devices demonstrated CW threshold current densities near 100 A/cm(2), a twofold improvement over the previous world record, that resulted in peak power conversion efficiencies increasing to 16% at 170C. Comparable narrow ridge two-stage devices generated more than 100 mW of CW power with similar to 10% power conversion efficiencies. Three-stage multimode cascade lasers emitted 960 mW of CW output power near 3 mu m and 120 mW CW near 3.3 mu m.
C1 [Shterengas, L.; Liang, R.; Hosoda, T.; Kipshidze, G.; Belenky, G.] SUNY Stony Brook, Stony Brook, NY 11794 USA.
[Bowman, S. S.; Tober, R. L.] Army Res Lab, Adelphi, MD 20783 USA.
RP Shterengas, L (reprint author), SUNY Stony Brook, Stony Brook, NY 11794 USA.
NR 14
TC 1
Z9 1
U1 2
U2 8
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-472-1
J9 PROC SPIE
PY 2015
VL 9382
AR 93820X
DI 10.1117/12.2076631
PG 9
WC Engineering, Electrical & Electronic; Optics; Physics, Applied
SC Engineering; Optics; Physics
GA BC6FH
UT WOS:000353892500019
ER
PT S
AU Merkle, LD
Zhang, J
Allen, G
Dawson, JW
Dubinskii, M
AF Merkle, Larry D.
Zhang, Jun
Allen, Graham
Dawson, Jay W.
Dubinskii, Mark
BE Jiang, S
Digonnet, MJF
TI Raman Gain of SiC as a Potential Medium for Raman Lasers
SO OPTICAL COMPONENTS AND MATERIALS XII
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Optical Components and Materials XII
CY FEB 09-11, 2015
CL San Francisco, CA
SP SPIE
DE Raman gain; Raman laser; SiC
ID POLYTYPES
AB We have investigated stimulated Raman scattering in the 4H polytype of SiC, due to its excellent thermal conductivity which is of great importance for power scaling of Raman lasers. Spectroscopy verifies the sample's polytype and precludes any significant admixture of other polytypes. Tests indicate the moderate optical quality of this commercially available sample. Using pump-probe measurements around 1030 nm, we find the Raman gain coefficient of the major peak at 777 cm(-1) to be 0.46 cm/GW. Although this value is only modest, calculations and experience with other Raman materials indicate that Raman lasing of 4H SiC should be possible with reasonable intensities of 1064-nm pulsed pumping.
C1 [Merkle, Larry D.; Zhang, Jun; Dubinskii, Mark] RDRL SEE L, Army Res Lab, Adelphi, MD 20783 USA.
[Allen, Graham; Dawson, Jay W.] Lawrence Livermore Natl Lab, Livermore, CA 94550 USA.
RP Merkle, LD (reprint author), RDRL SEE L, Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM larry.d.merkle.civ@mail.mil
NR 8
TC 0
Z9 0
U1 1
U2 5
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-449-3
J9 PROC SPIE
PY 2015
VL 9359
AR 935904
DI 10.1117/12.2077299
PG 6
WC Materials Science, Multidisciplinary; Optics
SC Materials Science; Optics
GA BC6OT
UT WOS:000354268500003
ER
PT S
AU Cole, B
Goldberg, L
Hough, N
Nettleton, J
AF Cole, Brian
Goldberg, Lew
Hough, Nathaniel
Nettleton, John
BE Clarkson, WA
Shori, RK
TI Investigation of mechanically Q-switched lasers
SO SOLID STATE LASERS XXIV: TECHNOLOGY AND DEVICES
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Solid State Lasers XXIV - Technology and Devices
CY FEB 08-10, 2015
CL San Francisco, CA
SP SPIE
DE Solid state lasers; Er/Yb glass laser; Nd:YAG; mechanical Q-switch; MEMS
Q-switch
ID MICROMIRROR; MIRROR
AB Using a resonant scanner mirror Q-switch to provide a time varying change in cavity alignment, 1535nm lasers based on Er/Yb-doped glass and 1064nm lasers based on Nd:YAG were evaluated. Using a side pumping architecture, the Er/Yb glass laser used a compact mechanical Q-switch with a mirror rotation rate of 330 Rad/s, enabling generation of >3 mJ pulses with a pulse width of 16ns. The laser output was a diffraction limited TEM00 mode. A mechanical Q-switch based on a MEMS tilting mirror was also used; its performance in a laser cavity was found to be similar to the resonant mirror. The technique of mechanical Q-switching was also extended to a side pumped Nd: YAG laser (mirror sweep rate of 1300 Rad/s), enabling generation of Q-switched pulses of >30mJ and 25ns duration. The far-field divergence showed this laser to be highly multi-moded within the pump plane, with a measured beam-product-parameter greater than 30 mm-mRad.
C1 [Cole, Brian; Goldberg, Lew; Hough, Nathaniel; Nettleton, John] US Army, Night Vis & Elect Sensors Directorate, RDECOM CERDEC, Ft Belvoir, VA 22060 USA.
RP Cole, B (reprint author), US Army, Night Vis & Elect Sensors Directorate, RDECOM CERDEC, Ft Belvoir, VA 22060 USA.
EM info@nvl.army.mil
NR 9
TC 1
Z9 1
U1 2
U2 4
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-432-5
J9 PROC SPIE
PY 2015
VL 9342
AR 93421P
DI 10.1117/12.2081256
PG 7
WC Engineering, Electrical & Electronic; Optics; Physics, Applied
SC Engineering; Optics; Physics
GA BC6FA
UT WOS:000353888400045
ER
PT S
AU Evans, JW
Sanamyan, T
Berry, PA
AF Evans, Jonathan W.
Sanamyan, Tigran
Berry, Patrick A.
BE Clarkson, WA
Shori, RK
TI A continuous-wave Fe:ZnSe laser pumped by an efficient Er:Y2O3 laser
SO SOLID STATE LASERS XXIV: TECHNOLOGY AND DEVICES
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Solid State Lasers XXIV - Technology and Devices
CY FEB 08-10, 2015
CL San Francisco, CA
SP SPIE
DE solid-state lasers; mid-IR lasers; transition-metal lasers
ID FE/ZNSE LASER; ZNSE
AB Fe:ZnSe lasers have been pumped by several types of diode-pumped solid state laser, including Cr:Er:YSGG (2800 nm),(1) Cr:CdSe (2970 nm),(2) and Er:YAG (2698 nm,(3) 2936 nm(4)). None of these sources has exceeded 1.5 W of true continuous-wave (CW) output power. In this work, we report demonstration of a CW Fe:ZnSe laser pumped by a 10 W Er:Y2O3 laser emitting at 2740 nm,(5) which had not been previously attempted. The Er:Y2O3 pump laser was characterized with respect to propagation losses, beam quality, mode size, and pointing stability. It was determined that the limit of output power from the Fe:ZnSe laser was limited by the output stability of the pump laser. The Fe:ZnSe laser operated with >22% slope efficiency and 800 mW output power was achieved at approximately 4050 nm.
C1 [Evans, Jonathan W.; Berry, Patrick A.] Air Force Res Lab, Sensors Directorate, Wright Patterson AFB, OH 45433 USA.
[Sanamyan, Tigran] Army Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA.
RP Evans, JW (reprint author), Air Force Res Lab, Sensors Directorate, Wright Patterson AFB, OH 45433 USA.
EM jonathan.evans.6@us.af.mil
NR 7
TC 0
Z9 0
U1 3
U2 16
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-432-5
J9 PROC SPIE
PY 2015
VL 9342
AR UNSP 93420F
DI 10.1117/12.2079757
PG 6
WC Engineering, Electrical & Electronic; Optics; Physics, Applied
SC Engineering; Optics; Physics
GA BC6FA
UT WOS:000353888400012
ER
PT S
AU Shen, TC
Drost, RJ
Rzasa, J
Sadler, BM
Davis, CC
AF Shen, Thomas C.
Drost, Robert J.
Rzasa, John
Sadler, Brian M.
Davis, Christopher C.
BE Hemmati, H
Boroson, DM
TI Panoramic Alignment System for Optical Wireless Communication Systems
SO FREE-SPACE LASER COMMUNICATION AND ATMOSPHERIC PROPAGATION XXVII
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Free-Space Laser Communication and Atmospheric Propagation
XXVII
CY FEB 08-09, 2015
CL San Francisco, CA
SP SPIE
DE light-emitting diodes; free space optical systems; pointing acquisition
and tracking
ID RF; LIGHT
AB Free space optical communication may provide a viable adjunct to radio frequency (RF) technology for mobile communications, especially in "RF-denied" settings in which RF-based communication may be prohibited or impractical. These settings may include military tactical environments or settings which suffer from RF jamming or interference. Unlike many RF communication systems, point-to-point optical communications between mobile nodes typically require establishing and maintaining alignment, which requires each node to have awareness of the locations of neighboring nodes. We propose a method to create this situational awareness between nodes using purely optical means. This method uses a camera that is focused on a hyperboloidal mirror, thus providing a 360-degree view of the surrounding environment. The camera and mirror are used to detect light emitted from the beacon transmitters from neighboring nodes, with the location of the beacon image in the sensor plane of the camera yielding elevation and azimuth information of the beacon. The beacon transmitter itself is modulated, allowing it to be distinguished from the environment. In discussing our experimental realization of this system, we assess its performance.
C1 [Shen, Thomas C.; Rzasa, John; Davis, Christopher C.] Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA.
[Drost, Robert J.; Sadler, Brian M.] US Army Res Lab, Adelphi, MD USA.
RP Shen, TC (reprint author), Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA.
EM tshen@umd.edu
NR 22
TC 2
Z9 2
U1 2
U2 4
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-444-8
J9 PROC SPIE
PY 2015
VL 9354
AR 93540M
DI 10.1117/12.2080091
PG 6
WC Engineering, Electrical & Electronic; Optics; Physics, Applied
SC Engineering; Optics; Physics
GA BC6AR
UT WOS:000353710100018
ER
PT J
AU Kwon, P
Lundin, J
Li, WJ
Ray, R
Littell, C
Gao, DL
Thomas, DB
Checkoway, H
AF Kwon, Paul
Lundin, Jessica
Li, Wenjin
Ray, Roberta
Littell, Christopher
Gao, Daoli
Thomas, David B.
Checkoway, Harvey
TI Night Shift Work and Lung Cancer Risk Among Female Textile Workers in
Shanghai, China
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE
LA English
DT Article
DE Chinese female; lung cancer; night shift; shift work; textile workers
ID ESTROGEN-RECEPTOR-BETA; BREAST SELF-EXAMINATION; NEVER SMOKERS; COTTON
DUST; RANDOMIZED-TRIAL; UNITED-STATES; WOMEN; ENDOTOXIN; MELATONIN;
EXPOSURE
AB In 2007, the International Agency for Research on Cancer classified shift work that involves circadian disruption as a probable human carcinogen. Suppression of the antineoplastic hormone, melatonin, is a presumed mechanism of action. We conducted a case-cohort study nested within a cohort of 267,400 female textile workers in Shanghai, China. Newly diagnosed lung cancer cases (n = 1451) identified during the study period (1989-2006) were compared with an age-stratified subcohort (n = 3040). Adjusting for age, smoking, parity, and endotoxin exposure, relative risks [hazard ratios (HRs)] were estimated by Cox regression modeling to assess associations with cumulative years and nights of rotating shift work. Results did not consistently reveal any increased risk of lung cancer among rotating shift work or statistically significant trends for both cumulative years (HR 0.82, 95% CI 0.66 to 1.02; P-trend = 0.294) and nights (HR 0.81, 95% CI 0.65 to 1.00; P-trend = 0.415). Further analyses imposing 10- and 20-year lag times for disease latency also revealed similar results. Contrary to the initial hypothesis, rotating nighttime shift work appears to be associated with a relatively reduced lung cancer risk although the magnitude of the effect was modest and not statistically significant.
C1 [Kwon, Paul] Bassett Army Community Hosp, Dept Prevent Med, Ft Wainwright, AK USA.
[Lundin, Jessica] Univ Washington, Dept Environm & Occupat Hlth Sci, Seattle, WA 98195 USA.
[Li, Wenjin; Ray, Roberta; Thomas, David B.] Fred Hutchinson Canc Res Ctr, Dept Epidemiol, Seattle, WA 98104 USA.
[Littell, Christopher] Walter Reed Army Inst Res, Dept Epidemiol, Rockville, MD USA.
[Gao, Daoli] Fudan Univ, Zhongshan Hosp, Dept Epidemiol, Shanghai 200433, Peoples R China.
[Checkoway, Harvey] Univ Calif San Diego, Dept Family & Prevent Med, La Jolla, CA 92093 USA.
RP Kwon, P (reprint author), Bassett Army Community Hosp MCUC PM, Ft Wainwright, AK 99703 USA.
EM drpaulkwon@gmail.com
FU National Institutes of Health (NIH) [NIH R01CA80180]
FX This work was supported by a National Institutes of Health (NIH) grant
(NIH R01CA80180).
NR 47
TC 3
Z9 3
U1 2
U2 9
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1545-9624
EI 1545-9632
J9 J OCCUP ENVIRON HYG
JI J. Occup. Environ. Hyg.
PY 2015
VL 12
IS 5
BP 334
EP 341
DI 10.1080/15459624.2014.993472
PG 8
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA CG8UP
UT WOS:000353590000010
PM 25616851
ER
PT B
AU Boutte, A
Kobeissy, F
Wang, KKW
Zhang, ZQ
Tortella, F
Dave, JR
Schmid, K
AF Boutte, Angela
Kobeissy, Firas
Wang, Kevin K. W.
Zhang, Zhiqun
Tortella, Frank
Dave, Jitendra R.
Schmid, Kara
BE Wang, KKW
Zhang, Z
Kobeissy, FH
TI Protein Biomarkers in Traumatic Brain Injury: An Omics Approach
SO BIOMARKERS OF BRAIN INJURY AND NEUROLOGICAL DISORDERS
LA English
DT Article; Book Chapter
ID CONTROLLED CORTICAL IMPACT; ALPHA-II-SPECTRIN; TANDEM MASS-SPECTROMETRY;
FIBRILLARY ACIDIC PROTEIN; DIFFERENCE GEL-ELECTROPHORESIS; ELEVATED
INTRACRANIAL-PRESSURE; CENTRAL-NERVOUS-SYSTEM; CEREBROSPINAL-FLUID;
PROTEOMIC ANALYSIS; LABEL-FREE
C1 [Boutte, Angela; Tortella, Frank; Dave, Jitendra R.; Schmid, Kara] Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Branch Brain Trauma Neuroprotect & Neurorestorat, Silver Spring, MD 20910 USA.
[Kobeissy, Firas; Wang, Kevin K. W.; Zhang, Zhiqun] Univ Florida, McKnight Brain Inst, Ctr Neuroprote & Biomarkers Res, Dept Psychiat, Gainesville, FL 32611 USA.
[Kobeissy, Firas; Wang, Kevin K. W.; Zhang, Zhiqun] Univ Florida, McKnight Brain Inst, Ctr Neuroprote & Biomarkers Res, Dept Neurosci, Gainesville, FL 32611 USA.
RP Boutte, A (reprint author), Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Branch Brain Trauma Neuroprotect & Neurorestorat, Silver Spring, MD 20910 USA.
EM angela.m.boutte.civ@mail.mil
RI kobeissy, firas/E-7042-2017
OI kobeissy, firas/0000-0002-5008-6944
NR 159
TC 0
Z9 0
U1 0
U2 3
PU CRC PRESS-TAYLOR & FRANCIS GROUP
PI BOCA RATON
PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA
BN 978-1-4822-3983-6; 978-1-4822-3982-9
PY 2015
BP 42
EP 75
PG 34
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA BC5QT
UT WOS:000353498500004
ER
PT B
AU Johnson, EA
Yassin, W
Guignet, M
AF Johnson, Erik A.
Yassin, Walid
Guignet, Michelle
BE Wang, KKW
Zhang, Z
Kobeissy, FH
TI Inflammatory Biomarkers of Brain Injury and Disease
SO Biomarkers of Brain Injury and Neurological Disorders
LA English
DT Article; Book Chapter
ID TUMOR-NECROSIS-FACTOR; INTERLEUKIN-1 RECEPTOR ANTAGONIST;
CENTRAL-NERVOUS-SYSTEM; FOCAL CEREBRAL-ISCHEMIA; ACUTE-PHASE RESPONSE;
GLUTAMATE-INDUCED EXCITOTOXICITY; MICROVASCULAR ENDOTHELIAL-CELLS;
INDUCED STATUS EPILEPTICUS; MESSENGER-RNA EXPRESSION; GROWTH-FACTOR
PRODUCTION
C1 [Johnson, Erik A.; Guignet, Michelle] US Army, Med Res Inst Chem Def, Div Res, Pharmacol Branch, Aberdeen Proving Ground, MD 21010 USA.
[Yassin, Walid] Kyoto Univ, Grad Sch Med, Dept Neuropsychiat, Kyoto 6068501, Japan.
RP Johnson, EA (reprint author), US Army, Med Res Inst Chem Def, Div Res, Pharmacol Branch, 3100 Ricketts Point, Aberdeen Proving Ground, MD 21010 USA.
EM erik.a.johnson1.civ@mail.mil
NR 254
TC 0
Z9 0
U1 0
U2 0
PU CRC PRESS-TAYLOR & FRANCIS GROUP
PI BOCA RATON
PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA
BN 978-1-4822-3983-6; 978-1-4822-3982-9
PY 2015
BP 304
EP 339
PG 36
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA BC5QT
UT WOS:000353498500012
ER
PT S
AU Dang, G
Taysing-Lara, M
Zhou, WM
Sun, TB
Yang, WJ
Chang-Hasnain, CJ
AF Dang, Gerard
Taysing-Lara, Monica
Zhou, Weimin
Sun, Tianbo
Yang, Weijian
Chang-Hasnain, Connie J.
BE ChangHasnain, CJ
Fattal, D
Koyama, F
Zhou, W
TI Design and fabrication of 3D high-contrast metastructure THz cage
waveguides
SO HIGH CONTRAST METASTRUCTURES IV
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on High Contrast Metastructures IV
CY FEB 11-12, 2015
CL San Francisco, CA
SP SPIE
DE hollow-core waveguide; high-contrast gratings; silicon; metastructure;
THz
AB We have designed new THz metastructure waveguides on Si wafers, aimed for low propagation loss and integration with Si-based integrated circuits. The waveguide has a round cross-sectional hollow-core, surrounded by high reflection-cladding-walls formed by high-contrast metastructure gratings. We developed a new fabrication technique to fabricate such a 3D metastructure cage waveguide structure. The waveguide is built using the entire wafer thickness which involves deep Si etching of periodically spaced holes and using isotropic undercut etching to create a connecting a line of etched spheres in the middle of the wafer to form the waveguide's hollow core, then deep etch the high-contrast grating through the entire wafer thickness to form the cladding for the waveguide. We have successfully modeled and fabricated such a waveguide structure. The next step is to experimentally test and characterize the waveguide in the THz spectrum range.
C1 [Dang, Gerard; Taysing-Lara, Monica; Zhou, Weimin] US Army, Res Lab, Adelphi, MD 20783 USA.
[Sun, Tianbo; Yang, Weijian; Chang-Hasnain, Connie J.] Univ Calif Berkeley, Berkeley, CA 94704 USA.
RP Dang, G (reprint author), US Army, Res Lab, Adelphi, MD 20783 USA.
NR 5
TC 0
Z9 0
U1 0
U2 3
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-462-2
J9 PROC SPIE
PY 2015
VL 9372
AR 93720J
DI 10.1117/12.2079720
PG 8
WC Optics
SC Optics
GA BC5JG
UT WOS:000353321800012
ER
PT J
AU Gunasekara, I
Mukerjee, S
Plichta, EJ
Hendrickson, MA
Abraham, KM
AF Gunasekara, Iromie
Mukerjee, Sanjeev
Plichta, Edward J.
Hendrickson, Mary A.
Abraham, K. M.
TI A Study of the Influence of Lithium Salt Anions on Oxygen Reduction
Reactions in Li-Air Batteries
SO JOURNAL OF THE ELECTROCHEMICAL SOCIETY
LA English
DT Article
ID IONIC LIQUID; ELECTROLYTE; SOLVENTS; ELECTROCHEMISTRY; MICROELECTRODE;
PERMITTIVITY; TEMPERATURES; PERFORMANCE; CHEMISTRY; MOLECULE
AB The influence of lithium salts on O-2 reduction reactions (ORR) in I. 2-dimethoxyethane (DME) and tetraethylene glycol dimethyl ether (TEGDME) has been investigated. Microelectrode studies in a series of tetrabutylammonium salt (TBA salt)/DME-based electrolytes showed that O-2 solubility and diffusion coefficient are not significantly affected by the electrolyte anion. The ORR voltammograms on microelectrodes in these electrolytes exhibited steady-state limiting current behavior. In contrast, peak-shaped voltammograms were observed in Li+-conducting electrolytes suggesting a reduction of the effective electrode area by passivating ORR products as well as migration-diffusion control of the reactants at the microelectrode. FT-IR spectra have revealed that Li+ ions are solvated to form solvent separated ion pairs of the type Li+(DME)(n)PF6- and Li-(TEGDME)PF6- in LiPF6-based electrolytes. On the other hand, the contact ion pairs (DME),Li+(CF3S03) and(TEGDNIE)Li+(CF3SO3-) appear to form in LiSO3CF3-containing electrolytes. In the LiSO3CF3 based electrolytes the initial ORR product, superoxide (O-2). is stabilized in solution by forming I(DME)(m-1) (O-2(-))[Li+(CF3SO3-) and RTEGDME)(O-2(-))1Li(+)(CF3SO3-) complexes. These soluble superoxide complexes are able to diffuse away from the electrode surface reaction sites to the bulk electrolyte in the electrode pores where they decompose to form Li2O2. This explains the higher capacity obtained in Li/02 cells utilizing LiCF3SO3-/TEGDME electrolytes. (C) 2015 The Electrochemical Society. All rights reserved.
C1 [Gunasekara, Iromie; Mukerjee, Sanjeev; Abraham, K. M.] Northeastern Univ, Dept Chem & Chem Biol, Boston, MA 02115 USA.
[Plichta, Edward J.; Hendrickson, Mary A.] US Army, Power Div, RDECOM CERDEC CP&I, RDER CCP, Aberdeen Proving Ground, MD 21005 USA.
RP Gunasekara, I (reprint author), Northeastern Univ, Dept Chem & Chem Biol, Boston, MA 02115 USA.
EM kmabraham@comcast.net
FU U.S. Army CERDEC [GTS-S-13-025]
FX We sincerely thank U.S. Army CERDEC for the financial support provided
through subcontract No. GTS-S-13-025 for this work.
NR 35
TC 21
Z9 21
U1 3
U2 60
PU ELECTROCHEMICAL SOC INC
PI PENNINGTON
PA 65 SOUTH MAIN STREET, PENNINGTON, NJ 08534 USA
SN 0013-4651
EI 1945-7111
J9 J ELECTROCHEM SOC
JI J. Electrochem. Soc.
PY 2015
VL 162
IS 6
BP A1055
EP A1066
DI 10.1149/2.0841506jes
PG 12
WC Electrochemistry; Materials Science, Coatings & Films
SC Electrochemistry; Materials Science
GA CG1BZ
UT WOS:000353009300037
ER
PT S
AU Chee, J
Hwu, J
Kim, TS
Kubby, J
Velicu, S
Gupta, N
AF Chee, J.
Hwu, J.
Kim, T. S.
Kubby, J.
Velicu, S.
Gupta, N.
BE Piyawattanametha, W
Park, YH
TI Large Size MOEMS Fabry-Perot Interferometer Filter for Focal Plane Array
Hyperspectral Imaging
SO MOEMS AND MINIATURIZED SYSTEMS XIV
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on MOEMS and Miniaturized Systems XIV
CY FEB 09-12, 2015
CL San Francisco, CA
SP SPIE, Samsung Adv Inst Technol
DE Fabry-Perot interferometer filter (FPF); micro-opto-electro-mechanical
systems (MOEMS); focal place array (FPA); long wavelength infrared
(LWIR)
AB Focal plane array (FPA) technology is mature and is widely used for imaging applications. However, FPAs have broadband responses which limit their ability to provide high performance in hyperspectral applications such as detection of buried explosives, and identifying the presence of explosive chemicals and their concentrations. EPIR is currently developing Micro-Opto-Electro-Mechanical System (MOEMS) Fabry-Perot interferometer filter (FPF) devices for FPAs. In this paper, we present our approach to MOEMS FPF design and fabrication that will meet the size requirements for large format FPA hyperspectral imaging. We also report the performance of our FPF resonance cavity, capable of up to 3 mu m change gap in tens of nanometer increments.
C1 [Chee, J.; Velicu, S.] EPIR Technol, Bolingbrook, IL 60440 USA.
[Hwu, J.; Kim, T. S.; Kubby, J.] Univ Calif Santa Cruz, Dept Elect Engn, Santa Cruz, CA 95064 USA.
[Gupta, N.] US Army Res Lab, Adelphi, MD 20783 USA.
RP Chee, J (reprint author), EPIR Technol, 590 Terr Dr, Bolingbrook, IL 60440 USA.
EM jchee@epir.com
NR 7
TC 0
Z9 0
U1 0
U2 1
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-465-3
J9 PROC SPIE
PY 2015
VL 9375
AR 93750K
DI 10.1117/12.2076615
PG 7
WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology;
Optics
SC Engineering; Science & Technology - Other Topics; Optics
GA BC5AI
UT WOS:000353125900016
ER
PT S
AU Milanovic, V
Kasturi, A
Atwood, B
Su, Y
Limkrailassiri, K
Nettleton, JE
Goldberg, L
Cole, BJ
Hough, N
AF Milanovic, Veljko
Kasturi, Abhishek
Atwood, Bryan
Su, Yu
Limkrailassiri, Kevin
Nettleton, John E.
Goldberg, Lew
Cole, Brian J.
Hough, Nathaniel
BE Piyawattanametha, W
Park, YH
TI Compact MEMS Mirror Based Q-Switch Module for Pulse-on-demand Laser
Range Finders
SO MOEMS AND MINIATURIZED SYSTEMS XIV
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on MOEMS and Miniaturized Systems XIV
CY FEB 09-12, 2015
CL San Francisco, CA
SP SPIE, Samsung Adv Inst Technol
DE MEMS; MEMS Mirror; Q-Switch; HR mirror; Er:Glass; Er/Yb; laser range
finder
ID MICRO-MIRROR; SYSTEM
AB A highly compact and low power consuming Q-switch module was developed based on a fast single-axis MEMS mirror, for use in eye-safe battery-powered laser range finders. The module's 1.6mm x 1 6mm mirror has >99% reflectance at 1535nm wavelength and can achieve mechanical angle slew rates of over 500 rad/sec when switching the Er/Yb:Glass lasing cavity from pumping to lasing state. The design targeted higher efficiency, smaller size, and lower cost than the traditional Electro-Optical Q-Switch. Because pulse-on-demand capability is required, resonant mirrors cannot be used to achieve the needed performance. Instead, a fast point-to-point analog single-axis tilt actuator was designed with a custom-coated high reflectance (HR) mirror to withstand the high intra-cavity laser fluence levels. The mirror is bonded on top of the MEMS actuator in final assembly. A compact MEMS controller was further implemented with the capability of autonomous on-demand operation based on user-provided digital trigger. The controller is designed to receive an external 3V power supply and a digital trigger and it consumes similar to 90mW during the short switching cycle and similar to 10mW in standby mode. Module prototypes were tested in a laser cavity and demonstrated high quality laser pulses with duration of 20ns and energy of over 3mJ.
C1 [Milanovic, Veljko; Kasturi, Abhishek; Atwood, Bryan; Su, Yu; Limkrailassiri, Kevin] Mirrorcle Technol Inc, Richmond, CA 94804 USA.
[Nettleton, John E.; Goldberg, Lew; Cole, Brian J.] US ARMY Night Vis & Elect Sensors Directorate, Ft Belvoir, VA USA.
[Hough, Nathaniel] Fibertek Inc, Ft Belvoir, VA USA.
RP Milanovic, V (reprint author), Mirrorcle Technol Inc, Richmond, CA 94804 USA.
NR 16
TC 0
Z9 0
U1 1
U2 3
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-1-62841-465-3
J9 PROC SPIE
PY 2015
VL 9375
AR 93750H
DI 10.1117/12.2082212
PG 7
WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology;
Optics
SC Engineering; Science & Technology - Other Topics; Optics
GA BC5AI
UT WOS:000353125900013
ER
PT J
AU Miller, AE
Brosi, BJ
Magnacca, K
Daily, GC
Pejchar, L
AF Miller, Adam E.
Brosi, Berry J.
Magnacca, Karl
Daily, Gretchen C.
Pejchar, Liba
TI Pollen Carried By Native and Nonnative Bees in the Large-scale
Reforestation of Pastureland in Hawai'i: Implications for Pollination
SO PACIFIC SCIENCE
LA English
DT Article
ID BIODIVERSITY HOTSPOTS; INTRODUCED HONEYBEES; FORAGING BEHAVIOR;
APIS-MELLIFERA; FRUIT-SET; CONSERVATION; ISLANDS; MUTUALISMS; FLOWERS;
COMMUNITIES
AB Due to habitat loss, disease, and introduction of nonnative species, many native species in Hawai'i have gone extinct or are at risk of extinction. As a result of interspecific interactions such as pollination, the decline, loss, or introduction of species can have cascading effects on island ecosystems. We studied Hylaeus spp., Hawai'i's yellow-faced bees, the only native bees in Hawai'i. This group of potentially important pollinators has been largely overlooked until recently, and its conservation status and ecological role are virtually unknown. We investigated how native (Hylaeus spp.) and nonnative (Apis mellifera) bees interact with flowering plants in a large-scale pasture-to-forest restoration system. We used pan traps and nets to collect bees in mature forest, remnant corridors, planted Acacia koa tracts, and open pastureland. We removed pollen from each specimen and identified it using pollen samples collected on-site. We found that Hylaeus spp. were more likely to carry less pollen and more likely to exhibit higher pollinator fidelity compared with A. mellifera. By contrast, A. mellifera was more likely to carry mixed pollen and forage on invasive plant species. This is the first investigation in Hawai` i to compare patterns of pollen carriage between native and nonnative bees and the first study to document pollen carried by Hylaeus spp. in the context of forest restoration.
C1 [Miller, Adam E.; Pejchar, Liba] Colorado State Univ, Dept Fish Wildlife & Conservat Biol, Ft Collins, CO 80523 USA.
[Brosi, Berry J.] Emory Univ, Dept Environm Sci, Atlanta, GA 30322 USA.
[Magnacca, Karl] Oahu Army Nat Resources Program, Pacific Cooperat Studies Unit, Schofield Barracks, HI 96857 USA.
[Daily, Gretchen C.] Stanford Univ, Dept Biol, Stanford, CA 94305 USA.
[Daily, Gretchen C.] Stanford Univ, Woods Inst, Stanford, CA 94305 USA.
RP Pejchar, L (reprint author), Colorado State Univ, Dept Fish Wildlife & Conservat Biol, Ft Collins, CO 80523 USA.
EM Liba.pejchar@colostate.edu
FU Moore Family Foundation; Winslow Foundation; Peter and Helen Bing
FX Funding provided by the Moore Family Foundation, the Winslow Foundation,
and Peter and Helen Bing.
NR 67
TC 1
Z9 1
U1 10
U2 41
PU UNIV HAWAII PRESS
PI HONOLULU
PA 2840 KOLOWALU ST, HONOLULU, HI 96822 USA
SN 0030-8870
EI 1534-6188
J9 PAC SCI
JI Pac. Sci.
PD JAN
PY 2015
VL 69
IS 1
BP 67
EP 79
DI 10.2984/69.1.5
PG 13
WC Marine & Freshwater Biology; Zoology
SC Marine & Freshwater Biology; Zoology
GA CG3HR
UT WOS:000353171100005
ER
PT J
AU Brasfield, SM
Hewitt, LM
Chow, L
Batchelor, S
Rees, H
Xing, ZS
Munkittrick, KR
AF Brasfield, Sandra M.
Hewitt, L. Mark
Chow, Lien
Batchelor, Suzanne
Rees, Herb
Xing, Zisheng
Munkittrick, Kelly R.
TI Assessing the contribution of multiple stressors affecting small-bodied
fish populations through a gradient of agricultural inputs in
northwestern New Brunswick, Canada
SO WATER QUALITY RESEARCH JOURNAL OF CANADA
LA English
DT Article
DE pesticides; precipitation; sculpin; small-bodied fish; temperature
ID SCULPIN COTTUS-COGNATUS; SLIMY SCULPIN; POTATO PRODUCTION; SOIL-EROSION;
RUNOFF; WATER; SIZE; RECRUITMENT; PESTICIDES; POLLUTION
AB Non-point source discharges, such as agricultural runoff, are often complex mixtures of chemical and non-chemical stressors. The complexity of runoff is compounded by its sporadic releases and few studies have attempted to assess the impacts of runoff on aquatic biota. In this study, an effects based approach was used to examine survival and reproduction of slimy sculpin (Cottus cognatus) in the intensive potato-farming areas of northwestern New Brunswick, Canada. Using non-lethal methods, fish were collected during the ice-free months through a gradient of agricultural intensity. These data were correlated with waterborne levels of pesticides, water temperatures and precipitation data. Results indicate that both adult and young-of-the-year (YOY) fish are longer and heavier in the downstream sites draining areas of higher agricultural intensity. Precipitation has a significant negative relationship with %YOY in the agricultural areas but not in the upstream forested area, indicating that contaminants are present in runoff caused by intensive rainfall events. Our results indicate that YOY sculpin may be at higher risk in the agricultural areas in years of heavier summer rains where peaks in pesticide levels occur. This study expands the existing knowledge base and development of non-lethal methods to define cause-effect relationships.
C1 [Brasfield, Sandra M.] US Army, Engn Res & Dev Ctr, Waterways Expt Stn, Environm Risk Assessment Branch,EP R CEERD, Vicksburg, MS 39180 USA.
[Brasfield, Sandra M.; Munkittrick, Kelly R.] Univ New Brunswick, Canadian Rivers Inst, Dept Biol, St John, NB E2L 4L5, Canada.
[Hewitt, L. Mark; Batchelor, Suzanne] Environm Canada, Aquat Ecosyst Protect Res Branch, Burlington, ON L7R 4A6, Canada.
[Chow, Lien; Rees, Herb] Agr & Agri Food Canada, Potato Res Ctr, Fredericton, NB E3B 4Z7, Canada.
[Xing, Zisheng] Univ New Brunswick, Fac Forestry & Environm Management, Fredericton, NB E3B 5A3, Canada.
RP Brasfield, SM (reprint author), US Army, Engn Res & Dev Ctr, Waterways Expt Stn, Environm Risk Assessment Branch,EP R CEERD, 3909 Halls Ferry Rd,Bldg 3270, Vicksburg, MS 39180 USA.
EM sandra.m.brasfield@usace.army.mil
FU Canadian Water Network; New Brunswick Innovation Fund; Environment
Canada's Pesticide Science Fund; Natural Sciences and Engineering
Research Council (NSERC); NSERC Discovery Grant; Networks of Centres of
Excellence; Canada Research Chairs Program
FX The authors received funding from the Canadian Water Network, the New
Brunswick Innovation Fund, Environment Canada's Pesticide Science Fund
and Natural Sciences and Engineering Research Council (NSERC). The
invaluable help of countless field assistants, graduate students, and
visiting scholars is greatly appreciated. Kelly Munkittrick receives
support from a NSERC Discovery Grant, the Canadian Water Network,
Networks of Centres of Excellence and from the Canada Research Chairs
Program.
NR 38
TC 0
Z9 0
U1 5
U2 15
PU IWA PUBLISHING
PI LONDON
PA ALLIANCE HOUSE, 12 CAXTON ST, LONDON SW1H0QS, ENGLAND
SN 1201-3080
J9 WATER QUAL RES J CAN
JI Water Qual. Res. J. Canada
PY 2015
VL 50
IS 2
BP 182
EP 197
DI 10.2166/wqrjc.2014.126
PG 16
WC Water Resources
SC Water Resources
GA CG3ZW
UT WOS:000353220300007
ER
PT J
AU Alford, KL
AF Alford, Kenneth L.
TI Nels Anderson's World War I Diary
SO BYU STUDIES QUARTERLY
LA English
DT Book Review
C1 [Alford, Kenneth L.] Brigham Young Univ, Church Hist & Doctrine, Provo, UT 84602 USA.
[Alford, Kenneth L.] US Army, Wright Patterson AFB, OH USA.
[Alford, Kenneth L.] US Mil Acad, West Point, NY USA.
[Alford, Kenneth L.] Natl Def Univ, Washington, DC 20319 USA.
RP Alford, KL (reprint author), Brigham Young Univ, Church Hist & Doctrine, Provo, UT 84602 USA.
NR 2
TC 0
Z9 0
U1 0
U2 0
PU BRIGHAM YOUNG UNIV
PI PROVO
PA 290 LIFE SCIENCE MUSEUM, PROVO, UT 84602 USA
SN 0007-0106
J9 BYU STUD Q
JI BYU Stud. Q.
PY 2015
VL 54
IS 1
BP 197
EP 200
PG 4
WC Humanities, Multidisciplinary
SC Arts & Humanities - Other Topics
GA CF8QB
UT WOS:000352825900016
ER
PT J
AU Schafer, JL
Breslow, BP
Hohmann, MG
Hoffmann, WA
AF Schafer, Jennifer L.
Breslow, Bradley P.
Hohmann, Matthew G.
Hoffmann, William A.
TI RELATIVE BARK THICKNESS IS CORRELATED WITH TREE SPECIES DISTRIBUTIONS
ALONG A FIRE FREQUENCY GRADIENT
SO FIRE ECOLOGY
LA English
DT Article
DE bark accumulation; inner bark proportion; longleaf pine savanna; Pinus;
Quercus; stream-head pocosin
ID TROPICAL SAVANNA; SURFACE FIRES; FOREST TREES; RESISTANCE; STRATEGIES;
MORTALITY; DYNAMICS; HABITAT; TRAITS; REGIME
AB The probability of stem survival after fire is strongly influenced by energy allocation to bark because bark thickness affects heat transfer during fire. Greater relative investment in inner bark versus outer bark should also enhance survival because of greater moisture content of inner bark. We measured stem diameter, bark thickness, and habitat preference of five species typical of long-leaf pine savannas, and six species characteristic of adjacent wetlands (pocosins), and calculated relative bark thickness, the inner bark proportion, radial growth, and bark accumulation of each species. We hypothesized that savanna species have thicker bark and greater relative investment in inner bark than pocosin species, because fires occur more frequently in savannas than pocosins. As hypothesized, savanna species have relatively thicker bark than pocosin species. Relative bark thickness and the rate of bark accumulation were correlated with the mean location of a species along the pocosin-to-savanna gradient. However, the inner bark proportion did not differ between savanna and pocosin species. Our results indicate that relative bark thickness is likely the primary bark trait affecting fire-induced topkill and influencing the distribution of species along the pocosin-to-savanna gradient.
C1 [Schafer, Jennifer L.; Breslow, Bradley P.; Hoffmann, William A.] N Carolina State Univ, Dept Plant & Microbial Biol, Raleigh, NC 27695 USA.
[Hohmann, Matthew G.] US Army, Corps Engineers, Engineer Res & Dev Ctr, Champaign, IL 61826 USA.
RP Schafer, JL (reprint author), William Jewell Coll, Dept Biol, 500 Coll Hill, Liberty, MO 64068 USA.
EM schaferj@william.jewell.edu
FU US Army Engineer Research and Development Center [W9132T-11-2-0007];
North Carolina State University [W9132T-11-2-0007]
FX The authors thank A. Bova for helpful discussions, S. Smith for
statistical advice, and J. Gray and S. Pulsipher for logistical support.
This manuscript was improved by comments from two anonymous reviewers
and an associate editor. This research was supported by a cooperative
agreement between the US Army Engineer Research and Development Center
and North Carolina State University (W9132T-11-2-0007 to W. Hoffmann).
NR 47
TC 3
Z9 3
U1 12
U2 37
PU ASSOC FIRE ECOLOGY
PI EUGENE
PA PO BOX 50412, EUGENE, OR 97405 USA
SN 1933-9747
J9 FIRE ECOL
JI Fire Ecol.
PY 2015
VL 11
IS 1
BP 74
EP 87
DI 10.4996/fireecology.1101074
PG 14
WC Ecology; Forestry
SC Environmental Sciences & Ecology; Forestry
GA CF6GJ
UT WOS:000352654800006
ER
PT J
AU Bufler, TD
Narayanan, RM
Dogaru, T
AF Bufler, Travis D.
Narayanan, Ram M.
Dogaru, Traian
TI Radar Signatures of Furniture Elements
SO IEEE TRANSACTIONS ON AEROSPACE AND ELECTRONIC SYSTEMS
LA English
DT Article
ID DIELECTRIC-PROPERTIES; GHZ; PERMITTIVITY; PROPAGATION; ANTENNAS
AB Through-the-wall radar (TTWR) systems designed for detecting, locating, and tracking humans are plagued by harsh clutter scenarios caused by the variety and abundance of furniture elements within the antenna's field of view. This paper investigates the signatures of indoor clutter using radar cross section (RCS) and linear depolarization ratios to implement clutter suppression algorithms. The paper focuses on the analysis of common individual and composite pieces of indoor clutter for TTWR. The characterization of the wideband spectral properties of indoor clutter elements is accomplished using finite-difference time-domain (FDTD) techniques. Using FDTD, the spectral characteristics of clutter elements are obtained over a wide range of frequencies, different polarizations, and aspect angles. We compare and contrast the RCS responses between the different objects for analysis and use in TTWR. RCS results obtained from the simulations are compared to experimental data using a network analyzer and reasonable agreement is obtained. Clutter signatures are also compared to those of humans in order to design appropriate waveforms for maximizing the signal-to-clutter ratio in TTWR systems.
C1 [Bufler, Travis D.; Narayanan, Ram M.] Penn State Univ, Elect Engn, University Pk, PA 16802 USA.
[Dogaru, Traian] US Army Res Lab, Adelphi, MD 20783 USA.
RP Bufler, TD (reprint author), Penn State Univ, Elect Engn, 202 EE East Bldg, University Pk, PA 16802 USA.
EM ram@engr.psu.edu
NR 26
TC 4
Z9 5
U1 1
U2 7
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0018-9251
EI 1557-9603
J9 IEEE T AERO ELEC SYS
JI IEEE Trans. Aerosp. Electron. Syst.
PD JAN
PY 2015
VL 51
IS 1
BP 521
EP 535
DI 10.1109/TAES.2014.140301
PG 15
WC Engineering, Aerospace; Engineering, Electrical & Electronic;
Telecommunications
SC Engineering; Telecommunications
GA CF6XT
UT WOS:000352700900041
ER
PT J
AU Zhang, SS
AF Zhang, Sheng S.
TI The redox mechanism of FeS2 in non-aqueous electrolytes for lithium and
sodium batteries
SO JOURNAL OF MATERIALS CHEMISTRY A
LA English
DT Review
ID ABSORPTION FINE-STRUCTURE; POLYMER ELECTROLYTE; CRYSTAL-STRUCTURE;
ELECTROCHEMICAL SYSTEM; POSITIVE ELECTRODES; PHASE-RELATIONSHIPS; PYRITE
ELECTRODE; SOLID-STATE; TEMPERATURE; CATHODES
AB Primary Li/FeS2 batteries have been commercialized and rechargeable Li-alloy/FeS2 batteries have been successfully operated at 375-500 degrees C by employing LiCl-based molten electrolytes. However, non-aqueous electrolyte rechargeable Li/FeS2 batteries have not yet been fulfilled due to poor reversibility and rapid capacity fading. The redox mechanism of FeS2 in non-aqueous electrolytes at ambient temperature is poorly understood and is still debated. In this mini-review, we analyse the experimental observations reported previously and propose a suitable mechanism that can explain all of the phenomena observed from the non-aqueous electrolyte Li/FeS2 and Na/FeS2 batteries.
C1 US Army Res Lab, Electrochem Branch, RDRL SED C, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA.
RP Zhang, SS (reprint author), US Army Res Lab, Electrochem Branch, RDRL SED C, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA.
EM shengshui.zhang.civ@mail.mil
RI Zhang, Sheng/A-4456-2012
OI Zhang, Sheng/0000-0003-4435-4110
NR 29
TC 32
Z9 32
U1 25
U2 135
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 2050-7488
EI 2050-7496
J9 J MATER CHEM A
JI J. Mater. Chem. A
PY 2015
VL 3
IS 15
BP 7689
EP 7694
DI 10.1039/c5ta00623f
PG 6
WC Chemistry, Physical; Energy & Fuels; Materials Science,
Multidisciplinary
SC Chemistry; Energy & Fuels; Materials Science
GA CF3IF
UT WOS:000352441100001
ER
PT J
AU Scime, EE
Keiter, PA
Balkey, MM
Kline, JL
Sun, X
Keesee, AM
Hardin, RA
Biloiu, IA
Houshmandyar, S
Thakur, SC
Carr, J
Galante, M
McCarren, D
Sears, S
AF Scime, E. E.
Keiter, P. A.
Balkey, M. M.
Kline, J. L.
Sun, X.
Keesee, A. M.
Hardin, R. A.
Biloiu, I. A.
Houshmandyar, S.
Thakur, S. Chakraborty
Carr, J., Jr.
Galante, M.
McCarren, D.
Sears, S.
TI The hot hELicon eXperiment (HELIX) and the large experiment on
instabilities and anisotropy (LEIA)
SO JOURNAL OF PLASMA PHYSICS
LA English
DT Article
ID ION TEMPERATURE ANISOTROPY; PLASMA; MAGNETOSHEATH; FREQUENCY; ELECTRON;
DEVICE
AB The West Virginia University Hot hELIcon eXperiment (HELIX) provides variable density and ion temperature plasmas, with controllable levels of thermal anisotropy, for space relevant laboratory experiments in the Large Experiment on Instabilities and Anisotropy (LEIA) as well as fundamental studies of helicon source physics in HELIX. Through auxiliary ion heating, the ion temperature anisotropy (T-perpendicular to/T-parallel to) is variable from 1 to 20 for parallel plasma beta (beta = 8 pi nkT(i parallel to)/B-2) values that span the range of 0.0001 to 0.01 in LEIA. The ion velocity distribution function is measured throughout the discharge volume in steady-state and pulsed plasmas with laser induced fluorescence (LIF). The wavelengths of very short wavelength electrostatic fluctuations are measured with a coherent microwave scattering system. Operating at low neutral pressures triggers spontaneous formation of a current-free electric double layer. Ion acceleration through the double layer is detected through LIF. LIF-based velocity space tomography of the accelerated beam provides a two-dimensional mapping of the bulk and beam ion distribution functions. The driving frequency for the m = 1 helical antenna is continuously variable from 8.5 to 16 MHz and frequency dependent variations of the RF coupling to the plasma allow the spontaneously appearing double layers to be turned on and off without modifying the plasma collisionality or magnetic field geometry. Single and multi-species plasmas are created with argon, helium, nitrogen, krypton, and xenon. The noble gas plasmas have steep neutral density gradients, with ionization levels reaching 100% in the core of the plasma source. The large plasma density in the source enables the study of Aflven waves in the HELIX device.
C1 [Scime, E. E.; Balkey, M. M.; Keesee, A. M.; McCarren, D.; Sears, S.] Univ Virginia, Dept Phys & Astron, Morgantown, WV 26506 USA.
[Keiter, P. A.] Univ Michigan, Dept Atmospher & Space Sci, Ann Arbor, MI 48109 USA.
[Kline, J. L.] Los Alamos Natl Lab, Los Alamos, NM 87545 USA.
[Sun, X.] Univ Sci & Technol China, Dept Modern Phys, Hefei 230026, Anhui, Peoples R China.
[Hardin, R. A.] Wacker Polysilicon North Amer LLC, Charleston, TN 37310 USA.
[Biloiu, I. A.] US Army Res Lab, Adelphi, MD 20783 USA.
[Houshmandyar, S.] Gonzaga Univ, Dept Phys, Spokane, WA 99258 USA.
[Thakur, S. Chakraborty] Univ Calif San Diego, Energy Res Ctr, San Diego, CA 92093 USA.
[Carr, J., Jr.] Texas Lutheran Univ, Dept Phys, Seguin, TX 78155 USA.
[Galante, M.] Univ Wisconsin, Dept Phys, Madison, WI 53706 USA.
RP Scime, EE (reprint author), Univ Virginia, Dept Phys & Astron, Morgantown, WV 26506 USA.
EM escime@wvu.edu
OI Keesee, Amy/0000-0002-9719-3229; Kline, John/0000-0002-2271-9919
FU NSF [PHY-0611571]
FX This work was supported by NSF award PHY-0611571. The authors thank one
referee for suggesting the additional comparison with the theory of
Reference 51 that is now shown in Fig. 15.
NR 45
TC 4
Z9 4
U1 0
U2 11
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0022-3778
EI 1469-7807
J9 J PLASMA PHYS
JI J. Plasma Phys.
PD JAN
PY 2015
VL 81
AR 345810103
DI 10.1017/S0022377814000890
PN 1
PG 22
WC Physics, Fluids & Plasmas
SC Physics
GA CE9WF
UT WOS:000352193400020
ER
PT J
AU Taylor, TZ
Psotka, J
Legree, P
AF Taylor, Teresa Z.
Psotka, Joseph
Legree, Peter
TI Relationships among applications of tacit knowledge and
transformational/transactional leader styles An exploratory comparison
of the MLQ and TKML
SO LEADERSHIP & ORGANIZATION DEVELOPMENT JOURNAL
LA English
DT Article
DE Tacit knowledge; Transactional leadership; Practical intelligence;
Transformational leadership; Leader levels; Problem solving
ID SITUATIONAL JUDGMENT TESTS; PERFORMANCE; VALIDITY; AGREEMENT; SKILLS
AB Purpose - The purpose of this paper is to examine intercorrelational relations among the self-report behavioral construct Multifactor Leadership Questionnaire (MLQ) 5X transformational and transactional subscales and the Tacit Knowledge for Military Leaders Inventory (TKML) leader-level specific situational judgment test scenarios.
Design/methodology/approach - In total, two leadership measures, the behavioral construct MLQ and the cognitive construct TKML assess different aspects of how a leader functions and were administered to 125 active US Army officers representing three leader levels: platoon, company, and battalion. The authors examine the intercorrelational relationship between these two measures.
Findings - Results show a correlational pattern that contours the evolution of a leader's skills (from novice platoon leader to expert battalion leader), with the strongest correlation at the higher leader levels.
Research limitations/implications - The decision to restrict the number of TKML scenarios provided to respondents and to administer the MLQ and TKML to the same sample is considered a limitation.
Practical implications - Pairing the MLQ and TKML makes use of self-reported leader behaviors with maximal assessment scales that directly assess respondents' understanding of what the best approaches to good leadership are.
Social implications - Response patterns from both measures permits direct counseling on the misconceptions about leadership to create better leaders.
Originality/value - No previous research has examined correlative relations among the scales/subscales of the MLQ and TKML.
C1 [Taylor, Teresa Z.] Boise State Univ, Dept Psychol, Boise, ID 83725 USA.
[Psotka, Joseph; Legree, Peter] US Army Res Inst Behav & Social Sci, Arlington, VA USA.
RP Taylor, TZ (reprint author), Boise State Univ, Dept Psychol, Boise, ID 83725 USA.
NR 61
TC 1
Z9 1
U1 4
U2 19
PU EMERALD GROUP PUBLISHING LIMITED
PI BINGLEY
PA HOWARD HOUSE, WAGON LANE, BINGLEY BD16 1WA, W YORKSHIRE, ENGLAND
SN 0143-7739
EI 1472-5347
J9 LEADERSHIP ORG DEV J
JI Leadersh. Org. Dev. J.
PY 2015
VL 36
IS 2
BP 120
EP 136
DI 10.1108/LODJ-01-2013-0008
PG 17
WC Management
SC Business & Economics
GA CF8BO
UT WOS:000352780500002
ER
PT J
AU Priddy, LP
Doyle, JD
Flintsch, GW
Pittman, DW
Anderton, GL
AF Priddy, Lucy P.
Doyle, Jesse D.
Flintsch, Gerardo W.
Pittman, David W.
Anderton, Gary L.
TI Three-dimensional modelling of precast concrete pavement repair joints
SO MAGAZINE OF CONCRETE RESEARCH
LA English
DT Article
ID FINITE-ELEMENT-ANALYSIS; PLASTIC-DAMAGE MODEL; DESIGN
AB This paper examines the mechanical response of precast panel pavement repair joints under static aircraft loadings using the finite-element method. Three-dimensional finite-element models were developed using the Abaqus software code, and their results were compared to and validated against results of full-scale field tests and theoretical calculations. Unlike previous pavement repair modelling efforts for precast panels and dowel retrofitting studies, all parts of the repair joint were modelled, including the dowels, dowel slot material, parent concrete, precast panel and pavement sublayers. Results show that high stress concentrations occur in the dowel slot material and that the current panel design is likely to be improved by modifying the dowel diameter.
C1 [Priddy, Lucy P.; Doyle, Jesse D.; Anderton, Gary L.] US Army ERDC, Vicksburg, MS 39180 USA.
[Flintsch, Gerardo W.] Virginia Polytech Inst & State Univ, Blacksburg, VA 24061 USA.
[Pittman, David W.] US Army ERDC, Geotech & Struct Lab, Vicksburg, MS USA.
RP Priddy, LP (reprint author), US Army ERDC, Vicksburg, MS 39180 USA.
FU US Air Force Civil Engineer Center
FX Information described and presented herein, unless otherwise noted, was
obtained from research sponsored by the US Air Force Civil Engineer
Center and performed at the US Army Engineer Research and Development
Center. Permission to publish this information was granted by the
Director, Geotechnical and Structures Laboratory.
NR 30
TC 0
Z9 0
U1 2
U2 11
PU ICE PUBLISHING
PI WESTMINISTER
PA INST CIVIL ENGINEERS, 1 GREAT GEORGE ST, WESTMINISTER SW 1P 3AA, ENGLAND
SN 0024-9831
EI 1751-763X
J9 MAG CONCRETE RES
JI Mag. Concr. Res.
PY 2015
VL 67
IS 10
BP 513
EP 522
DI 10.1680/macr.14.00278
PG 10
WC Construction & Building Technology; Materials Science, Multidisciplinary
SC Construction & Building Technology; Materials Science
GA CF5JL
UT WOS:000352593200004
ER
PT J
AU Izvekov, S
Rice, BM
AF Izvekov, Sergei
Rice, Betsy M.
TI On the importance of shear dissipative forces in coarse-grained dynamics
of molecular liquids
SO PHYSICAL CHEMISTRY CHEMICAL PHYSICS
LA English
DT Article
ID PARTICLE DYNAMICS; MESOSCOPIC SIMULATION; SYSTEMS; HYDRODYNAMICS;
SURFACTANTS; FIELD; DPD; HMX
AB In this work we demonstrate from first principles that the shear frictions describing dissipative forces in the direction normal to the vector connecting the coarse-grained (CG) particles in dissipative particle dynamics (DPD) could be dominant for certain real molecular liquids at high-resolution coarse-graining. This is in contrast to previous works on bottom-up DPD modeling and indicates that such liquids cannot be simulated accurately using the conventional form of DPD which relies only on frictions in the radial direction. Specifically, we describe the development of fully bottom-up CG models for liquid hexahydro-1,3,5-trinitro-s-triazine (RDX) which are incorporated into the DPD method. Consistent with the microscopic foundation of DPD dynamics, the conservative part of the DPD models is obtained by the multi-scale coarse-graining (MS-CG) approach, which implements the pairwise decomposition of the atomistic potential of mean force (PMF) in CG coordinates. The radial and shear distant-dependent friction coefficients in a parameter-free form are derived systematically from microscopic velocity and force correlation data along system trajectories using a recently proposed approach [J. Chem. Phys., 2014, 140, 104104]. The shear dissipative forces for the reported system appear to be dominant. We discuss the implications of dominant shear dissipation on dynamical and transport properties of CG liquids such as diffusion and viscosity as revealed by simulations of liquid RDX using the new MS-CG/DPD models.
C1 [Izvekov, Sergei; Rice, Betsy M.] US Army, Weap & Mat Res Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Izvekov, S (reprint author), US Army, Weap & Mat Res Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM sergiy.izvyekov.civ@mail.mil
FU DoD High Performance Computing Modernization Program Software
Application Institute for Multiscale Reactive Modeling of Insensitive
Munitions
FX The authors wish to thank Dr John Brennan and Dr Joshua Moore of the
Army Research Laboratory for helpful comments. This work was supported
by the DoD High Performance Computing Modernization Program Software
Application Institute for Multiscale Reactive Modeling of Insensitive
Munitions.
NR 69
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U2 22
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 1463-9076
EI 1463-9084
J9 PHYS CHEM CHEM PHYS
JI Phys. Chem. Chem. Phys.
PY 2015
VL 17
IS 16
BP 10795
EP 10804
DI 10.1039/c4cp06116k
PG 10
WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical
SC Chemistry; Physics
GA CF7AB
UT WOS:000352707200053
PM 25812678
ER
PT J
AU Chappell, MA
Miller, LF
Price, CL
AF Chappell, Mark A.
Miller, Lesley F.
Price, Cynthia L.
TI Reversible exchange of stable nitroxyl radicals on nanosilver particles
SO ENVIRONMENTAL CHEMISTRY
LA English
DT Article
DE electron spin resonance; stable radicals; ultrasonication.
ID SILVER NANOPARTICLES; GOLD NANOPARTICLES; TOXICITY; CAVITATION; OH
AB Radicals drive important chemical reactions in the environment. These unpaired electron species can be generated by energetic inputs, such as electromagnetic radiation, or from ultrasonication processes, whereby oxygen radicals are generated in aqueous solution through a cavitation mechanism. Previous evidence has demonstrated the potential for radicals to be stored on the surface of metallic gold nanoparticles, thus suggesting a potential transference of radical species from the nanoparticle surface for catalytic reactions, particularly during preparations of nanoparticle suspensions through ultrasonication. This work investigates the potential for the nanosilver (nAg) particles to similarly scavenge radicals from solution. nAg suspensions were reacted with 0.3-mM solutions containing the stable nitroxy radicals 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO), 4-oxo-2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPONE) and 4-amino-2,2,6,6-tetramethylpiperidino-1-oxyl (TEMPAMINE) analysed by quantitative electron spin resonance (ESR) spectroscopy. In ambient air, the addition of a nAg suspension to the 0.3-mM solutions reduced the integrated ESR intensity of the stable radicals by 50-93% depending on radical species and nAg concentration, which we attributed to the sorption of the radicals onto the nAg surface. In separate experiments, the ESR intensities were further decreased under an Ar atmosphere, suggesting potential competition from ambient OH center dot to the sorption of the stable radicals. To verify this, we observed substantial increases in the integrated ESR intensity when the systems previously equilibrated under Ar atmosphere were exposed to ambient air. These results demonstrated that nAg scavenged the stable radicals from solution and were exchangeable from the metallic conduction band with OH center dot. Our work represents the first evidence for this mechanism to be demonstrated for nAg.
C1 [Chappell, Mark A.; Miller, Lesley F.; Price, Cynthia L.] US Army, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
RP Chappell, MA (reprint author), US Army, Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM mark.a.chappell@usace.army.mil
FU Military Materials in the Environment (MME) Program for the US Army
Engineer Research & Development (ERDC) Laboratory
FX This work was funded through the Military Materials in the Environment
(MME) Program for the US Army Engineer Research & Development (ERDC)
Laboratory. We express appreciation to Dr Elizabeth Ferguson, Technical
Director of the MME Program for her support. Opinions, interpretations,
conclusions and recommendations are those of the author(s) and are not
necessarily endorsed by the US Army.
NR 20
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U1 0
U2 1
PU CSIRO PUBLISHING
PI CLAYTON
PA UNIPARK, BLDG 1, LEVEL 1, 195 WELLINGTON RD, LOCKED BAG 10, CLAYTON, VIC
3168, AUSTRALIA
SN 1448-2517
EI 1449-8979
J9 ENVIRON CHEM
JI Environ. Chem.
PY 2015
VL 12
IS 2
BP 198
EP 203
DI 10.1071/EN14093
PG 6
WC Chemistry, Analytical; Environmental Sciences
SC Chemistry; Environmental Sciences & Ecology
GA CE7EB
UT WOS:000351999300012
ER
PT J
AU de Groot, M
Doyle, T
Averyt, J
Risaliti, C
Shubrook, J
AF de Groot, Mary
Doyle, Todd
Averyt, Jennifer
Risaliti, Carleen
Shubrook, Jay
TI DEPRESSIVE SYMPTOMS AND TYPE 2 DIABETES MELLITUS IN RURAL APPALACHIA: AN
18-MONTH FOLLOW-UP STUDY
SO INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE
LA English
DT Article
DE depressive symptoms; diabetes mellitus; rural
ID COMORBID DEPRESSION; ADULTS; METAANALYSIS; INDIVIDUALS; ASSOCIATION;
MORTALITY; QUALITY; IMPACT; WOMEN; CARE
AB Objective: Despite high rates of diabetes and depression in rural areas, limited data exists to document patterns and predictors of depressive symptoms in rural patients with type 2 diabetes (T2DM). The purpose of this study was to assess the rates and predictors of co-morbid depressive symptoms over an 18-month period in a cohort of rural Appalachian adults with T2DM. Methods: N=100 adult T2DM patients were recruited from family medicine and endocrinology practices located in the rural Appalachian counties of southeastern Ohio and West Virginia. Data were collected using a longitudinal observational survey design. Results: The sample consisted of predominantly White (93%) females (62%) who were married (71%), completed high school or less (48%), and had a mean age of 60 years (SD 11). Mean BDI score was 14.0 (SD 12) with 27% scoring in the moderate/severe range for depressive symptoms. A majority of patients (77%) reported depressive symptoms, at both time points, with 88% of these reporting consistent depressive symptoms in the year prior to study follow-up. Patients with depressive symptoms at Time 1 and Time 2 did not differ from other groups in the number of treatment strategies or medications used. Predictors of depressive symptoms in this group were increased diabetes treatment complexity (OR = 2.3), lack of home ownership (OR = 11.4), and decreased satisfaction with antidepressant medications (OR = 2.0; chi(2) = 28.9, p < .0001). Conclusions: Rural T2DM patients reported high rates of repeated depressive symptoms without corresponding rates of depression treatment. These patients may benefit from close monitoring and ongoing adjustment of their treatment for depression and diabetes by primary care providers.
C1 [de Groot, Mary] Indiana Univ, Indianapolis, IN 46204 USA.
[Doyle, Todd] Loyola Univ, Med Ctr, Maywood, IL 60153 USA.
[Averyt, Jennifer] Tripler Army Med Ctr, Honolulu, HI 96859 USA.
[Risaliti, Carleen] Ohio State Univ, Sch Med, Columbus, OH 43210 USA.
[Shubrook, Jay] Ohio Univ, Heritage Coll Osteopath Med, Athens, OH 45701 USA.
RP de Groot, M (reprint author), Diabet Translat Res Ctr, 410 W 10th St,Suite 1140, Indianapolis, IN 46240 USA.
EM mdegroot@iu.edu
FU Ohio University Diabetes Research Initiative; National Institute of
Diabetes, Digestive Diseases and Kidneys [R34DK071515]
FX We wish to gratefully acknowledge support for this study from Ohio
University Diabetes Research Initiative and the National Institute of
Diabetes, Digestive Diseases and Kidneys (R34DK071515).
NR 31
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U1 1
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0091-2174
EI 1541-3527
J9 INT J PSYCHIAT MED
JI Int. J. Psychiatr. Med.
PY 2015
VL 48
IS 4
BP 263
EP 277
DI 10.2190/PM.48.4.c
PG 15
WC Psychiatry
SC Psychiatry
GA CE9QK
UT WOS:000352178300003
PM 25817523
ER
PT J
AU Priscoli, JD
Hiroki, K
AF Priscoli, Jerome Delli
Hiroki, Kenzo
TI Water and Disasters: Cases from the High Level Experts and Leaders Panel
on Water and Disasters
SO WATER POLICY
LA English
DT Editorial Material
C1 [Priscoli, Jerome Delli] USACE, Washington, DC USA.
[Hiroki, Kenzo] MLIT, Dept Water Resources, Tsukuba, Ibaraki, Japan.
NR 11
TC 0
Z9 0
U1 2
U2 5
PU IWA PUBLISHING
PI LONDON
PA ALLIANCE HOUSE, 12 CAXTON ST, LONDON SW1H0QS, ENGLAND
SN 1366-7017
J9 WATER POLICY
JI Water Policy
PY 2015
VL 17
SU 1
BP 1
EP 5
DI 10.2166/wp.2015.000
PG 5
WC Water Resources
SC Water Resources
GA CF5AV
UT WOS:000352567800001
ER
PT S
AU Kashinski, DO
Talbi, D
Hickman, AP
AF Kashinski, D. O.
Talbi, D.
Hickman, A. P.
BE Schneider, IF
Dulieu, O
Robert, J
TI Using block diagonalization to determine dissociating autoionizing
states: Application to N2H, and the outlook for SH
SO DR2013: NINTH INTERNATIONAL CONFERENCE ON DISSOCIATIVE RECOMBINATION:
THEORY, EXPERIMENT, AND APPLICATIONS
SE EPJ Web of Conferences
LA English
DT Proceedings Paper
CT 9th International Conference on Dissociative Recombination: Theory,
Experiment, and Applications
CY JUL 07-12, 2013
CL Paris, FRANCE
ID DIABATIC STATES; RECOMBINATION; ABSORPTION; SYSTEM
AB We describe our implementation of the block diagonalization method for calculating the potential surfaces necessary to treat dissociative recombination (DR) of electrons with N2H+. Using the methodology we have developed over the past few years, we performed multi- reference, configuration interaction calculations for N2H+ and N2H with a large active space using the GAMESS electronic structure code. We treated both linear and bent geometries of the molecules, with N-2 fixed at its equilibrium separation. Because of the strong Rydberg-valence coupling in N2H, it is essential to isolate the appropriate dissociating, autoionizing states. Our procedure requires only modest additional effort beyond the standard methodology. The results indicate that the crossing between the dissociating neutral curve and the initial ion potential is not favorably located for DR, even if the molecule bends. The present calculations thereby confirm our earlier results for linear N2H and reinforce the conclusion that the direct mechanism for DR is likely to be inefficient. We also describe interesting features of our preliminary calculations on SH.
C1 [Kashinski, D. O.] US Mil Acad, Dept Phys & Nucl Engn, West Point, NY 10996 USA.
[Talbi, D.] Univ Montpellier 2, Lab Univers & Particules Montpellier, UMR 5299, F-34095 Montpellier, France.
[Hickman, A. P.] Lehigh Univ, Dept Phys, Bethlehem, PA 18015 USA.
RP Kashinski, DO (reprint author), US Mil Acad, Dept Phys & Nucl Engn, West Point, NY 10996 USA.
EM david.kashinski@usma.edu; dahbia.talbi@univ-montp2.fr; aph2@lehigh.edu
NR 16
TC 1
Z9 1
U1 0
U2 1
PU E D P SCIENCES
PI CEDEX A
PA 17 AVE DU HOGGAR PARC D ACTIVITES COUTABOEUF BP 112, F-91944 CEDEX A,
FRANCE
SN 2100-014X
J9 EPJ WEB CONF
PY 2015
VL 84
AR 03003
DI 10.1051/epjconf/20158403003
PG 9
WC Chemistry, Physical; Physics, Multidisciplinary
SC Chemistry; Physics
GA BC3PG
UT WOS:000351835100010
ER
PT J
AU Lu, Z
Wang, WY
Wang, C
AF Lu, Zhuo
Wang, Wenye
Wang, Cliff
TI Camouflage Traffic: Minimizing Message Delay for Smart Grid Applications
under Jamming
SO IEEE TRANSACTIONS ON DEPENDABLE AND SECURE COMPUTING
LA English
DT Article
DE Smart grid; wireless applications; performance modeling; worst-case
analysis; message delay; jamming attacks
ID NETWORKS; SYSTEMS
AB Smart grid is a cyber-physical system that integrates power infrastructures with information technologies. To facilitate efficient information exchange, wireless networks have been proposed to be widely used in the smart grid. However, the jamming attack that constantly broadcasts radio interference is a primary security threat to prevent the deployment of wireless networks in the smart grid. Hence, spread spectrum systems, which provide jamming resilience via multiple frequency and code channels, must be adapted to the smart grid for secure wireless communications, while at the same time providing latency guarantee for control messages. An open question is how to minimize message delay for timely smart grid communication under any potential jamming attack. To address this issue, we provide a paradigm shift from the case-by-case methodology, which is widely used in existing works to investigate well-adopted attack models, to the worst-case methodology, which offers delay performance guarantee for smart grid applications under any attack. We first define a generic jamming process that characterizes a wide range of existing attack models. Then, we show that in all strategies under the generic process, the worst-case message delay is a U-shaped function of network traffic load. This indicates that, interestingly, increasing a fair amount of traffic can in fact improve the worst-case delay performance. As a result, we demonstrate a lightweight yet promising system, transmitting adaptive camouflage traffic (TACT), to combat jamming attacks. TACT minimizes the message delay by generating extra traffic called camouflage to balance the network load at the optimum. Experiments show that TACT can decrease the probability that a message is not delivered on time in order of magnitude.
C1 [Lu, Zhuo; Wang, Wenye] N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27606 USA.
[Wang, Cliff] Army Res Off, Comp Sci, Res Triangle Pk, NC USA.
RP Lu, Z (reprint author), N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27606 USA.
EM zlu3@ncsu.edu; wwang@ncsu.edu; cliff.wang@us.army.mil
FU Army Research Office (ARO) staff research grant [W911NF-07-R-0001-05];
National science Foundation (NSF) Career Award [CNS-0546289]
FX The work was supported by Army Research Office (ARO) staff research
grant W911NF-07-R-0001-05 and National science Foundation (NSF) Career
Award CNS-0546289. Part of the work was presented in IEEE INFOCOM'12.
NR 27
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U1 1
U2 4
PU IEEE COMPUTER SOC
PI LOS ALAMITOS
PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA
SN 1545-5971
EI 1941-0018
J9 IEEE T DEPEND SECURE
JI IEEE Trans. Dependable Secur. Comput.
PD JAN-FEB
PY 2015
VL 12
IS 1
BP 31
EP 44
DI 10.1109/TDSC.2014.2316795
PG 14
WC Computer Science, Hardware & Architecture; Computer Science, Information
Systems; Computer Science, Software Engineering
SC Computer Science
GA CE7XC
UT WOS:000352054200003
ER
PT J
AU Hohenforst-Schmidt, W
Zarogoulidis, P
Stopek, J
Kosmidis, E
Vogl, T
Linsmeier, B
Tsakiridis, K
Lampaki, S
Lazaridis, G
Mpakas, A
Browning, R
Papaiwannou, A
Drevelegas, A
Baka, S
Karavasilis, V
Mpoukovinas, I
Turner, JF
Zarogoulidis, K
Brachmann, J
AF Hohenforst-Schmidt, Wolfgang
Zarogoulidis, Paul
Stopek, Joshua
Kosmidis, Efstratios
Vogl, Thomas
Linsmeier, Bernd
Tsakiridis, Kosmas
Lampaki, Sofia
Lazaridis, George
Mpakas, Andreas
Browning, Robert
Papaiwannou, Antonis
Drevelegas, Antonis
Baka, Sofia
Karavasilis, Vasilis
Mpoukovinas, Ioannis
Turner, J. Francis
Zarogoulidis, Konstantinos
Brachmann, Johannes
TI Enhancement of Intratumoral Chemotherapy with Cisplatin with or without
Microwave Ablation and Lipiodol. Future Concept for Local Treatment in
Lung Cancer
SO JOURNAL OF CANCER
LA English
DT Article
DE lung cancer; intratumoral; lipiodol; cisplatin; microwave ablation
ID COMBINED RADIOFREQUENCY ABLATION; LIPOSOMAL DOXORUBICIN; LIVER
METASTASES; GENE-THERAPY; CARCINOMA; SYSTEM; SIZE
AB Novel therapies for lung cancer are being explored nowadays with local therapies being the tip of the arrow. Intratumoral chemotherapy administration and local microwave ablation have been investigated in several studies. It has been previously proposed that lipiodol has the ability to modify the microenvironment matrix. In our current study we investigated this theory in BALBC mice. In total 160 BALBC mice were divided in eight groups: a) control, b) cisplatin, c) microwave, d) microwave and lipiodol, e) cisplatin and lipiodol, f) microwave and cisplatin, g) lipiodol and h) lipiodol, cisplatin and microwave. Lewis lung carcinoma cell lines (10(6)) were injected into the right back leg of each mouse. After the 8th day, when the tumor volume was about 100mm(3) the therapy application was initiated, once per week for four weeks. Magnetic resonance imaging was performed for each tumor when a mouse died or when sacrificed if they were still alive by the end of the experiment (8-Canal multifunctional spool; NORAS MRI products, Gmbh, Germany). Imaging and survival revealed efficient tumor apoptosis for the groups b, c, d, e and f. However; severe toxicity was observed in group h and no follow up was available for this group after the second week of therapy administration. Lipiodol in its current form does assist in a more efficient way the distribution of cisplatin, as the microwave apoptotic effect. Future modification of lipiodol might provide a more efficient method of therapy enhancement. Combination of drug and microwave ablation is possible and has an efficient apoptotic effect.
C1 [Hohenforst-Schmidt, Wolfgang; Brachmann, Johannes] Univ Wurzburg, Coburg Hosp, Med Clin 2, Coburg, Germany.
[Zarogoulidis, Paul; Lampaki, Sofia; Papaiwannou, Antonis; Zarogoulidis, Konstantinos] Aristotle Univ Thessaloniki, G Papanikolaou Gen Hosp, Dept Pulm, Oncol Unit, GR-54006 Thessaloniki, Greece.
[Stopek, Joshua] Covidien, Minneapolis, MN USA.
[Kosmidis, Efstratios] Aristotle Univ Thessaloniki, Sch Vet, GR-54006 Thessaloniki, Greece.
[Vogl, Thomas] Goethe Univ Frankfurt, Dept Diagnost & Intervent Radiol, D-60054 Frankfurt, Germany.
[Linsmeier, Bernd] Medinos Clin Sonneberg, Dept Thorac Surg, Sonnerberg, Germany.
[Tsakiridis, Kosmas; Mpakas, Andreas] St Luke Private Hosp, Dept Thorac Surg, Thessaloniki, Greece.
[Lazaridis, George; Karavasilis, Vasilis] Aristotle Univ Thessaloniki, Papageorgiou Gen Hosp, Dept Oncol, GR-54006 Thessaloniki, Greece.
[Browning, Robert] Walter Reed Army Med Ctr, Pulm & Crit Care Med, Intervent Pulmonol, Natl Naval Med Ctr, Bethesda, MD USA.
[Drevelegas, Antonis] Interbalkan European Med Ctr, Dept Radiol, Thessaloniki, Greece.
[Baka, Sofia] Interbalkan European Med Ctr, Dept Oncol, Thessaloniki, Greece.
[Mpoukovinas, Ioannis] BioMed Clin, Dept Oncol, Thessaloniki, Greece.
[Turner, J. Francis] Western Reg Med Ctr, Canc Treatment Centers Amer, Div Intervent Pulmonol & Med Oncol 2, Goodyear, AZ USA.
RP Zarogoulidis, P (reprint author), Aristotle Univ Thessaloniki, G Papanikolaou Gen Hosp, Dept Pulm, Oncol Unit, GR-54006 Thessaloniki, Greece.
EM pzarog@hotmail.com
NR 38
TC 1
Z9 2
U1 0
U2 4
PU IVYSPRING INT PUBL
PI LAKE HAVEN
PA PO BOX 4546, LAKE HAVEN, NSW 2263, AUSTRALIA
SN 1837-9664
J9 J CANCER
JI J. Cancer
PY 2015
VL 6
IS 3
BP 218
EP 226
DI 10.7150/jca.10970
PG 9
WC Oncology
SC Oncology
GA CE9BK
UT WOS:000352138200002
PM 25663938
ER
PT J
AU Jain, RB
Choi, YS
AF Jain, Ram B.
Choi, Y. Sammy
TI Normal reference ranges for and variability in the levels of blood
manganese and selenium by gender, age, and race/ethnicity for general US
population
SO JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
LA English
DT Article
DE Manganese; Selenium; Smoking; Gender; Race/ethnicity
ID CAFFEINE CONSUMPTION; DRINKING-WATER; EXPOSURE; TOXICITY; CHILDREN;
DEFICIENCY; EXPRESSION; BIPHENYLS; SMOKING; CANCER
AB Data from National Health and Nutrition Examination Survey for the period 2011-2012 were used to determine normal reference ranges and percentile distributions for manganese (Mn) and selenium (Se) in blood by gender, age, race/ethnicity, socioeconomic status as determined by annual family income, and smoking status. The effect of gender, age, race/ethnicity, family income, and smoking status on the levels of Mn and Se was also determined by fitting regression models. Males had lower adjusted levels of Mn and higher adjusted levels of Se than females. Adjusted levels of Mn decreased with increase in age but adjusted levels of Se were lower in adolescents aged 12-19 years than adults aged 20-64 years. Non-Hispanic black (NHB) had the lowest levels of both Mn and Se and non-Hispanic Asians (NHAS) had the highest levels of both Mn and Se. Non-Hispanic white (NHW) and NHB had lower levels of Mn than Hispanics (HISP) and NHAS. NHB and HISP had lower levels of Se than NHW and NHAS. Low annual income (<$20,000) was associated with lower levels of Se than high annual income (>=$55,000). Smoking negatively affected the adjusted levels of Se among seniors aged >= 65 years but this was not observed in other age groups. Mn levels were not affected by smoking. Published by Elsevier GmbH.
C1 [Jain, Ram B.; Choi, Y. Sammy] Womack Army Med Ctr, Ft Bragg, NC 28310 USA.
[Jain, Ram B.] Empiristat Inc, Mt Airy, MD USA.
RP Jain, RB (reprint author), Womack Army Med Ctr, 2817 Reilly Rd, Ft Bragg, NC 28310 USA.
EM ram.b.jain.ctr@mail.mil
NR 35
TC 5
Z9 5
U1 1
U2 5
PU ELSEVIER GMBH, URBAN & FISCHER VERLAG
PI JENA
PA OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY
SN 0946-672X
J9 J TRACE ELEM MED BIO
JI J. Trace Elem. Med. Biol.
PY 2015
VL 30
BP 142
EP 152
DI 10.1016/j.jtemb.2014.12.004
PG 11
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA CE4LL
UT WOS:000351802000024
PM 25596656
ER
PT B
AU Thompson, AS
Frentzos, CG
AF Thompson, Antonio S.
Frentzos, Christos G.
BE Thompson, AS
Frentzos, CG
TI THE ROUTLEDGE HANDBOOK OF AMERICAN MILITARY AND DIPLOMATIC HISTORY The
Colonial Period to 1877 INTRODUCTION
SO ROUTLEDGE HANDBOOK OF AMERICAN MILITARY AND DIPLOMATIC HISTORY: THE
COLONIAL PERIOD TO 1877
LA English
DT Editorial Material; Book Chapter
C1 [Thompson, Antonio S.] USMA, West Point, NY USA.
[Frentzos, Christos G.] Austin Peay State Univ, Clarksville, TN 37044 USA.
[Frentzos, Christos G.] US Mil Acad, Summer Mil Hist Seminar, West Point, NY USA.
[Frentzos, Christos G.] Tel Aviv Univ, Fdn Def Democracies Terrorism Studies Program, IL-69978 Tel Aviv, Israel.
RP Thompson, AS (reprint author), Austin Peay State Univ, Clarksville, TN 37044 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ROUTLEDGE
PI ABINGDON
PA 2 PARK SQ, MILTON PARK, ABINGDON OX14 4RN, OXFORD, ENGLAND
BN 978-1-315-81734-7; 978-0-415-53380-5
PY 2015
BP 1
EP 6
PG 6
WC History
SC History
GA BB9SG
UT WOS:000348591300001
ER
PT B
AU Warren, J
AF Warren, Jason
BE Thompson, AS
Frentzos, CG
TI THE SPIRIT OF '76 King Philip's War and Bacon's Rebellion, 1675-1676
SO ROUTLEDGE HANDBOOK OF AMERICAN MILITARY AND DIPLOMATIC HISTORY: THE
COLONIAL PERIOD TO 1877
LA English
DT Article; Book Chapter
C1 [Warren, Jason] US Army War Coll, Carlisle, PA USA.
NR 22
TC 0
Z9 0
U1 0
U2 0
PU ROUTLEDGE
PI ABINGDON
PA 2 PARK SQ, MILTON PARK, ABINGDON OX14 4RN, OXFORD, ENGLAND
BN 978-1-315-81734-7; 978-0-415-53380-5
PY 2015
BP 42
EP 50
PG 9
WC History
SC History
GA BB9SG
UT WOS:000348591300006
ER
PT B
AU Leeman, WP
AF Leeman, William P.
BE Thompson, AS
Frentzos, CG
TI WAR WITHOUT DECLARATION The Barbary Wars
SO ROUTLEDGE HANDBOOK OF AMERICAN MILITARY AND DIPLOMATIC HISTORY: THE
COLONIAL PERIOD TO 1877
LA English
DT Article; Book Chapter
C1 [Leeman, William P.] Salve Regina Univ, Newport, RI 02840 USA.
[Leeman, William P.] Salve Regina Univ, Pell Ctr Int Relat & Publ Policy, Newport, RI USA.
[Leeman, William P.] US Mil Acad, West Point, NY USA.
RP Leeman, WP (reprint author), Salve Regina Univ, Newport, RI 02840 USA.
NR 17
TC 0
Z9 0
U1 0
U2 0
PU ROUTLEDGE
PI ABINGDON
PA 2 PARK SQ, MILTON PARK, ABINGDON OX14 4RN, OXFORD, ENGLAND
BN 978-1-315-81734-7; 978-0-415-53380-5
PY 2015
BP 164
EP 171
PG 8
WC History
SC History
GA BB9SG
UT WOS:000348591300020
ER
PT B
AU Watson, S
AF Watson, Samuel
BE Thompson, AS
Frentzos, CG
TI FLORIDA FORAYS, FIASCOS, AND CONQUESTS Andrew Jackson, John Quincy
Adams, and the First Seminole War
SO ROUTLEDGE HANDBOOK OF AMERICAN MILITARY AND DIPLOMATIC HISTORY: THE
COLONIAL PERIOD TO 1877
LA English
DT Article; Book Chapter
C1 US Mil Acad, West Point, NY 10996 USA.
RP Watson, S (reprint author), US Mil Acad, West Point, NY 10996 USA.
NR 42
TC 0
Z9 0
U1 1
U2 1
PU ROUTLEDGE
PI ABINGDON
PA 2 PARK SQ, MILTON PARK, ABINGDON OX14 4RN, OXFORD, ENGLAND
BN 978-1-315-81734-7; 978-0-415-53380-5
PY 2015
BP 233
EP 240
PG 8
WC History
SC History
GA BB9SG
UT WOS:000348591300028
ER
PT B
AU Spahr, TW
AF Spahr, Thomas W.
BE Thompson, AS
Frentzos, CG
TI THE MEXICAN-AMERICAN WAR A Historiographical Overview
SO ROUTLEDGE HANDBOOK OF AMERICAN MILITARY AND DIPLOMATIC HISTORY: THE
COLONIAL PERIOD TO 1877
LA English
DT Article; Book Chapter
C1 [Spahr, Thomas W.] 4th Brigade Combat Team, New York, NY USA.
[Spahr, Thomas W.] 82nd Airborne Div, Ft Bragg, NC USA.
Southern Afghanistan, Kabul, Afghanistan.
[Spahr, Thomas W.] 7th Special Forces Grp, New York, NY USA.
[Spahr, Thomas W.] 75th Ranger Regiment, Ft Benning, GA USA.
RP Spahr, TW (reprint author), The Army, Washington, DC 20001 USA.
NR 37
TC 0
Z9 0
U1 0
U2 1
PU ROUTLEDGE
PI ABINGDON
PA 2 PARK SQ, MILTON PARK, ABINGDON OX14 4RN, OXFORD, ENGLAND
BN 978-1-315-81734-7; 978-0-415-53380-5
PY 2015
BP 259
EP 266
PG 8
WC History
SC History
GA BB9SG
UT WOS:000348591300031
ER
PT J
AU Joyner, MJ
Barnes, JN
Hart, EC
Wallin, BG
Charkoudian, N
AF Joyner, Michael J.
Barnes, Jill N.
Hart, Emma C.
Wallin, B. Gunnar
Charkoudian, Nisha
TI Neural Control of the Circulation: How Sex and Age Differences Interact
in Humans
SO COMPREHENSIVE PHYSIOLOGY
LA English
DT Article
ID SYMPATHETIC-NERVE ACTIVITY; ARTERIAL-BLOOD-PRESSURE; BODY
NEGATIVE-PRESSURE; HEART-RATE-VARIABILITY; GENDER-DIFFERENCES; HEALTHY
HUMANS; NITRIC-OXIDE; NORADRENALINE SPILLOVER; BAROREFLEX SENSITIVITY;
AUTONOMIC SUPPORT
AB The autonomic nervous system is a key regulator of the cardiovascular system. In this review, we focus on how sex and aging influence autonomic regulation of blood pressure in humans in an effort to understand general issues related to the cardiovascular system as a whole. Younger women generally have lower blood pressure and sympathetic activity than younger men. However, both sexes show marked interindividual variability across age groups with significant overlap seen. Additionally, while men across the lifespan show a clear relationship between markers of whole body sympathetic activity and vascular resistance, such a relationship is not seen in young women. In this context, the ability of the sympathetic nerves to evoke vasoconstriction is lower in young women likely as a result of concurrent beta(2)-mediated vasodilation that offsets alpha-adrenergic vasoconstriction. These differences reflect both central sympatho-inhibitory effects of estrogen and also its influence on peripheral vasodilation at the level of the vascular smooth muscle and endothelium. By contrast postmenopausal women show a clear relationship between markers of whole body sympathetic traffic and vascular resistance, and sympathetic activity rises progressively in both sexes with aging. These major findings in humans are discussed in the context of differences in population-based trends in blood pressure and orthostatic intolerance. The many areas where there is little sex-specific data on how the autonomic nervous system participates in the regulation of the human cardiovascular system are highlighted. (C) 2015 American Physiological Society.
C1 [Joyner, Michael J.; Barnes, Jill N.] Mayo Clin, Dept Anesthesiol, Rochester, MN 55902 USA.
[Hart, Emma C.] Univ Bristol, Sch Physiol & Pharmacol, Bristol, Avon, England.
[Wallin, B. Gunnar] Gothenburg Univ, Sahlgren Acad, Inst Neurosci & Physiol, Gothenburg, Sweden.
[Charkoudian, Nisha] US Army Res Inst Environm Med, Thermal & Mt Med Div, Natick, MA USA.
RP Joyner, MJ (reprint author), Mayo Clin, Dept Anesthesiol, Rochester, MN 55902 USA.
EM joyner.michael@mayo.edu
OI Hart, Emma/0000-0002-4534-9586
FU British Heart Foundation [FS/11/1/28400]; NCATS NIH HHS [UL1 TR000135];
NHLBI NIH HHS [HL-83947, R01 HL083947]; NIA NIH HHS [AG 38067, F32
AG038067]
NR 119
TC 20
Z9 20
U1 2
U2 9
PU JOHN WILEY & SONS INC
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 2040-4603
J9 COMPR PHYSIOL
JI Compr. Physiol.
PD JAN
PY 2015
VL 5
IS 1
BP 193
EP 215
DI 10.1002/cphy.c140005
PG 23
WC Physiology
SC Physiology
GA CE0JS
UT WOS:000351490900008
PM 25589269
ER
PT J
AU Bhat, S
Motz, LH
Pathak, C
Kuebler, L
AF Bhat, Shirish
Motz, Louis H.
Pathak, Chandra
Kuebler, Laura
TI Geostatistics-based groundwater-level monitoring network design and its
application to the Upper Floridan aquifer, USA
SO ENVIRONMENTAL MONITORING AND ASSESSMENT
LA English
DT Article
DE Groundwater-level monitoring; Groundwater well network design;
Groundwater management; Salinity-adjusted heads; Geostatistics; Kriging;
South Florida
ID SPATIAL VARIABILITY; OPTIMIZATION; CHINA; TIME; SPACE; DEPTH
AB A geostatistical method was applied to optimize an existing groundwater-level monitoring network in the Upper Floridan aquifer for the South Florida Water Management District in the southeastern United States. Analyses were performed to determine suitable numbers and locations of monitoring wells that will provide equivalent or better quality groundwater-level data compared to an existing monitoring network. Ambient, unadjusted groundwater heads were expressed as salinity-adjusted heads based on the density of freshwater, well screen elevations, and temperature-dependent saline groundwater density. The optimization of the numbers and locations of monitoring wells is based on a pre-defined groundwater-level prediction error. The newly developed network combines an existing network with the addition of new wells that will result in a spatial distribution of groundwater monitoring wells that better defines the regional potentiometric surface of the Upper Floridan aquifer in the study area. The network yields groundwater-level predictions that differ significantly from those produced using the existing network. The newly designed network will reduce the mean prediction standard error by 43 % compared to the existing network. The adoption of a hexagonal grid network for the South Florida Water Management District is recommended to achieve both a uniform level of information about groundwater levels and the minimum required accuracy. It is customary to install more monitoring wells for observing groundwater levels and groundwater quality as groundwater development progresses. However, budget constraints often force water managers to implement cost-effective monitoring networks. In this regard, this study provides guidelines to water managers concerned with groundwater planning and monitoring.
C1 [Bhat, Shirish; Motz, Louis H.] Univ Florida, Dept Civil & Coastal Engn, Gainesville, FL 32611 USA.
[Pathak, Chandra] US Army Corps Engineers, Headquarters, Washington, DC USA.
[Kuebler, Laura] South Florida Water Management Dist, Div Water Resources, Hydrol & Environm Syst Modeling Sect, W Palm Beach, FL USA.
RP Bhat, S (reprint author), Univ Florida, Dept Civil & Coastal Engn, Gainesville, FL 32611 USA.
EM shirish.bhat@gmail.com
FU South Florida Water Management District, West Palm Beach Florida
[4500057295]
FX The authors would like to thank Peter Kwiatkowski, Emily Richardson,
Cindy Bevier, Ceyda Polatel, and Kevin Zhu with the South Florida Water
Management District for their invaluable review comments and
suggestions. Financial support for this project was provided by the
South Florida Water Management District, West Palm Beach Florida, by
means of Purchase Order 4500057295.
NR 35
TC 3
Z9 3
U1 3
U2 16
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0167-6369
EI 1573-2959
J9 ENVIRON MONIT ASSESS
JI Environ. Monit. Assess.
PD JAN
PY 2015
VL 187
IS 1
AR 4183
DI 10.1007/s10661-014-4183-x
PG 15
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA CE0YB
UT WOS:000351535800006
PM 25433546
ER
PT J
AU Kesavan, J
Sagripanti, JL
AF Kesavan, Jana
Sagripanti, Jose-Luis
TI Evaluation criteria for bioaerosol samplers
SO ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS
LA English
DT Article
ID AEROSOL SAMPLERS; PERFORMANCE; PARTICLES; BACTERIAL; TESTS
AB Humans contract a variety of serious diseases through inhalation of infectious aerosols. Thus, the importance of monitoring air for microbial, toxic, or allergic content is recognized in clinical, occupational, and biodefense arenas. However, accurate monitoring of potentially contaminated environments can be hampered by selection of aerosol samplers with inadequate performance for the intended task. In this study, 29 aerosol samplers were evaluated based on their respective air flow, size, weight, power consumption, and efficiency in sampling particles in the respirable range. The resulting data demonstrates that sampling air flow and efficiency vary widely, and cannot be predicted from the physical characteristics of air samplers, and hence, that proper selection of air samplers should be more involved than shopping for a device based on the limited characteristics that are published by the manufacturers. The findings are summarized in an approach to rationally select bioaerosol samplers for use in infection control and environmental biomonitoring. The presented data demonstrates that inadequate selection of air samplers could result in a failure to collect particles of interest and thus, underestimate the risk and provide a false sense of security in contaminated health care settings and environments contaminated with infectious or toxic aerosols.
C1 [Kesavan, Jana; Sagripanti, Jose-Luis] US Army Edgewood Chem Biol Ctr, RDCB DRI A, Aberdeen Proving Ground, MD 21010 USA.
RP Kesavan, J (reprint author), US Army Edgewood Chem Biol Ctr, RDCB DRI A, E5951,5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA.
EM Jana.Kesavan@us.army.mil
FU Edgewood Chemical Biological Center, Aberdeen Proving Ground, Maryland
FX The project was funded by the Edgewood Chemical Biological Center,
Aberdeen Proving Ground, Maryland.
NR 28
TC 4
Z9 4
U1 6
U2 32
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 2050-7887
EI 2050-7895
J9 ENVIRON SCI-PROC IMP
JI Environ. Sci.-Process Impacts
PY 2015
VL 17
IS 3
BP 638
EP 645
DI 10.1039/c4em00510d
PG 8
WC Chemistry, Analytical; Environmental Sciences
SC Chemistry; Environmental Sciences & Ecology
GA CD9TM
UT WOS:000351441300014
PM 25631321
ER
PT J
AU Su, W
AF Su, Wei
TI Modulation Classification of Single-Input Multiple-Output Signals Using
Asynchronous Sensors
SO IEEE SENSORS JOURNAL
LA English
DT Article
DE Cognitive radio; distributed sensors; high-order statistics; modulation
classification; spectrum sensing; sensor network; single-input
multiple-output
ID CYCLIC CUMULANTS; FADING CHANNELS; LIKELIHOOD
AB This paper discusses the automatic modulation classification of weak communication signals using distributed low-cost sensors. The concept of a secondary user in sensor networks is presented and very high-order statistics are used as modulation features. Two feature-based methods, single-variable and multivariable modulation classifiers, are proposed for estimating unknown modulation schemes through single-input multiple-output signal sensing channels. The new approaches acquire multiple signal observations collected from distributed sensors and leverage the channel diversity to enhance signal power and reduce bias in estimation. The experiment demonstrates that the network centric modulation classifier achieves significantly improved performance in terms of probability of correct classification than the current state-of-the-art single sensor modulation classifier, and the multivariable modulation classifier is more robust to the channel parameter variations than the single-variable classifier.
C1 US Army, Commun Elect Res Dev & Engn Ctr, Aberdeen, MD 21001 USA.
RP Su, W (reprint author), US Army, Commun Elect Res Dev & Engn Ctr, Aberdeen, MD 21001 USA.
EM wei.su@ieee.org
NR 49
TC 2
Z9 2
U1 0
U2 0
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1530-437X
EI 1558-1748
J9 IEEE SENS J
JI IEEE Sens. J.
PD JAN
PY 2015
VL 15
IS 1
BP 346
EP 357
DI 10.1109/JSEN.2014.2343832
PG 12
WC Engineering, Electrical & Electronic; Instruments & Instrumentation;
Physics, Applied
SC Engineering; Instruments & Instrumentation; Physics
GA CD6SR
UT WOS:000351220200007
ER
PT J
AU Hoole, SRH
Karthik, VU
Sivasuthan, S
Rahunanthan, A
Thyagarajan, RS
Jayakumar, P
AF Hoole, S. Ratnajeevan H.
Karthik, Victor U.
Sivasuthan, Sivamayam
Rahunanthan, Arunasalam
Thyagarajan, Ravi S.
Jayakumar, Paramsothy
TI Finite elements, design optimization, and nondestructive evaluation: A
review in magnetics, and future directions in GPU-based,
element-by-element coupled optimization and NDE
SO INTERNATIONAL JOURNAL OF APPLIED ELECTROMAGNETICS AND MECHANICS
LA English
DT Article
DE Review; optimization; finite elements; GPU; NDE; ground vehicles
ID EDDY-CURRENT NDT; CONSTRAINED OPTIMIZATION; ELECTROMAGNETIC DEVICES;
MULTIOBJECTIVE OPTIMIZATION; GEOMETRIC PARAMETRIZATION; MAGNETOSTATIC
PROBLEMS; SYNCHRONOUS MACHINES; GRAPHICS PROCESSORS; ALGORITHM; FIELD
AB This paper reviews mathematical optimization in synthesis and nondestructive evaluation (NDE) by the finite element method in magnetics because background work has been inadequately attributed in the literature. The review identifies the earliest papers and reports new work in nondestructive evaluation and GPU-based matrix solution to save time and memory. Although the genetic algorithm has been applied in optimization, in coupled systems the number of object function evaluations doubles. We therefore examine the use of graphics processing units (GPUs) to handle the immense computational load. GPU memory limits are often not recognized and are critically limiting when parallelizing the several solutions required in optimization. To overcome this limit, element-by-element finite element matrix processing is employed, making coupled problems practicable on GPUs. We overcome the memory limits element-by-element processing, however, and achieve a GPU speedup of 147 by Jacobi conjugate gradients while forming the matrix of coefficients and of 80 (and growing indefinitely) by Gauss iterations without forming the matrix for situations where memory is scarce such as genetic algorithm optimization where several copies of the matrix have to be held on threads.
C1 [Hoole, S. Ratnajeevan H.; Karthik, Victor U.; Sivasuthan, Sivamayam] Michigan State Univ, Dept Elect & Comp Engn, E Lansing, MI 48824 USA.
[Rahunanthan, Arunasalam] Univ Toledo, Dept Math & Stat, Toledo, OH 43606 USA.
[Thyagarajan, Ravi S.; Jayakumar, Paramsothy] US Army Tank Automot Res Dev & Engn Ctr, Warren, MI USA.
RP Hoole, SRH (reprint author), Michigan State Univ, Dept Elect & Comp Engn, 2120 Engn Bldg,428 South Shaw Lane, E Lansing, MI 48824 USA.
EM srhhoole@gmail.com
FU US Army's Tank, Automotive Research, Development and Engineering Center
(TARDEC) [W911NF-11-D-0001]
FX This work was funded in part by the US Army's Tank, Automotive Research,
Development and Engineering Center (TARDEC) under contract number
W911NF-11-D-0001.
NR 81
TC 3
Z9 3
U1 2
U2 11
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1383-5416
EI 1875-8800
J9 INT J APPL ELECTROM
JI Int. J. Appl. Electromagn. Mech.
PY 2015
VL 47
IS 3
BP 607
EP 627
DI 10.3233/JAE-140061
PG 21
WC Engineering, Electrical & Electronic; Mechanics; Physics, Applied
SC Engineering; Mechanics; Physics
GA CD5SZ
UT WOS:000351149600003
ER
PT J
AU Fu, RX
Toonen, RC
Hirsch, SG
Ivill, MP
Cole, MW
Strawhecker, KE
AF Fu, Richard X.
Toonen, Ryan C.
Hirsch, Samuel G.
Ivill, Mathew P.
Cole, Melanie W.
Strawhecker, Kenneth E.
TI Fabrication of self-aligned, nanoscale, complex oxide varactors
SO JOURNAL OF MICRO-NANOLITHOGRAPHY MEMS AND MOEMS
LA English
DT Article
DE barium strontium titanate; e-beam lithography; inductively coupled
plasma etch
ID THIN-FILMS; PLASMA; SIZE
AB Applications in ferroelectric random access memory and superparaelectric devices require the fabrication of ferroelectric capacitors at the nanoscale that exhibit extremely small leakage currents. To systematically study the material-size dependence of ferroelectric varactor performance, arrays of parallel-plate structures have been fabricated with nanoscale dielectric diameters. Electron beam lithography and inductively coupled plasma dry etching have been used to fabricate arrays of ferroelectric varactors using top electrodes as a self-aligned etch mask. Parallel-plate test structures using RF-sputtered Ba0.6Sr0.4TiO3 thin-films were used to optimize the fabrication process. Varactors with diameters down to 20 nm were successfully fabricated. Current-voltage (I-V) characteristics were measured to evaluate the significance of etch-damage and fabrication quality by ensuring low leakage currents through the structures. (C) 2015 Society of Photo-Optical Instrumentation Engineers (SPIE)
C1 [Fu, Richard X.; Hirsch, Samuel G.; Ivill, Mathew P.; Cole, Melanie W.; Strawhecker, Kenneth E.] US Army Res Lab, Adelphi, MD 20783 USA.
[Toonen, Ryan C.] Univ Akron, Dept Elect & Comp Engn, ASEC 555, Akron, OH 44325 USA.
RP Fu, RX (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM richard.x.fu.civ@mail.mil
FU U.S. Army Research Laboratory (ARL) Director's Research Initiatives
[FY12-WMR-050]
FX The authors would like to thank Dr. Madhumita Roy and Dr. Justin
Bickford for their contributions toward e-beam lithography nanostructure
fabrication. Funding for this work was supported by U.S. Army Research
Laboratory (ARL) Director's Research Initiatives (FY12-WMR-050).
NR 19
TC 0
Z9 0
U1 6
U2 9
PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA
SN 1932-5150
EI 1932-5134
J9 J MICRO-NANOLITH MEM
JI J. Micro-Nanolithogr. MEMS MOEMS
PD JAN
PY 2015
VL 14
IS 1
AR UNSP 013508
DI 10.1117/1.JMM.14.1.013508
PG 5
WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology;
Materials Science, Multidisciplinary; Optics
SC Engineering; Science & Technology - Other Topics; Materials Science;
Optics
GA CE2IZ
UT WOS:000351640600016
ER
PT J
AU Kugelman, JR
Sanchez-Lockhart, M
Andersen, KG
Gire, S
Park, DJ
Sealfon, R
Lin, AE
Wohl, S
Sabeti, PC
Kuhn, JH
Palacios, GF
AF Kugelman, Jeffrey R.
Sanchez-Lockhart, Mariano
Andersen, Kristian G.
Gire, Stephen
Park, Daniel J.
Sealfon, Rachel
Lin, Aaron E.
Wohl, Shirlee
Sabeti, Pardis C.
Kuhn, Jens H.
Palacios, Gustavo F.
TI Evaluation of the Potential Impact of Ebola Virus Genomic Drift on the
Efficacy of Sequence-Based Candidate Therapeutics
SO MBIO
LA English
DT Article
ID NONHUMAN-PRIMATES; POSTEXPOSURE PROTECTION; MONOCLONAL-ANTIBODIES;
MORPHOLINO OLIGOMERS; RNA INTERFERENCE; ZAIRE-EBOLAVIRUS; INFECTION;
VARIANTS; DISEASE; NOMENCLATURE
AB Until recently, Ebola virus (EBOV) was a rarely encountered human pathogen that caused disease among small populations with extraordinarily high lethality. At the end of 2013, EBOV initiated an unprecedented disease outbreak in West Africa that is still ongoing and has already caused thousands of deaths. Recent studies revealed the genomic changes this particular EBOV variant undergoes over time during human-to-human transmission. Here we highlight the genomic changes that might negatively impact the efficacy of currently available EBOV sequence-based candidate therapeutics, such as small interfering RNAs (siRNAs), phosphorodiamidate morpholino oligomers (PMOs), and antibodies. Ten of the observed mutations modify the sequence of the binding sites of monoclonal antibody (MAb) 13F6, MAb 1H3, MAb 6D8, MAb 13C6, and siRNA EK-1, VP24, and VP35 targets and might influence the binding efficacy of the sequence-based therapeutics, suggesting that their efficacy should be reevaluated against the currently circulating strain.
C1 [Kugelman, Jeffrey R.; Sanchez-Lockhart, Mariano; Palacios, Gustavo F.] US Army Med Res Inst Infect Dis, Ctr Genome Sci Div, Frederick, MD 21702 USA.
[Andersen, Kristian G.; Gire, Stephen; Park, Daniel J.; Lin, Aaron E.; Wohl, Shirlee; Sabeti, Pardis C.] Harvard Univ, Ctr Syst Biol, Cambridge, MA 02138 USA.
[Sealfon, Rachel] MIT, Comp Sci & Artificial Intelligence Lab, Cambridge, MA 02139 USA.
[Kuhn, Jens H.] NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD USA.
RP Palacios, GF (reprint author), US Army Med Res Inst Infect Dis, Ctr Genome Sci Div, Frederick, MD 21702 USA.
EM gustavo.f.palacios.ctr@us.army.mil
RI Palacios, Gustavo/I-7773-2015;
OI Palacios, Gustavo/0000-0001-5062-1938; Kuhn, Jens H./0000-0002-7800-6045
FU Defense Threat Reduction Agency; NIAID [HHSN272200700016I]; National
Science Foundation Graduate research fellowship [DGE 1144152]
FX This work was supported by Defense Threat Reduction Agency. J.H.K.
performed this work as an employee of Tunnell Government Services, Inc.,
a subcontractor to Battelle Memorial Institute under its prime contract
with NIAID, under contract no. HHSN272200700016I. This material is based
upon work supported by the National Science Foundation Graduate research
fellowship under grant no. DGE 1144152.
NR 24
TC 22
Z9 23
U1 1
U2 15
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 2150-7511
J9 MBIO
JI mBio
PD JAN-FEB
PY 2015
VL 6
IS 1
AR e02227-14
DI 10.1128/mBio.02227-14
PG 4
WC Microbiology
SC Microbiology
GA CC8PZ
UT WOS:000350631900039
ER
PT J
AU Warren, TK
Whitehouse, CA
Wells, J
Welch, L
Heald, AE
Charleston, JS
Sazani, P
Reid, SP
Iversen, PL
Bavari, S
AF Warren, Travis K.
Whitehouse, Chris A.
Wells, Jay
Welch, Lisa
Heald, Alison E.
Charleston, Jay S.
Sazani, Pete
Reid, St Patrick
Iversen, Patrick L.
Bavari, Sina
TI A Single Phosphorodiamidate Morpholino Oligomer Targeting VP24 Protects
Rhesus Monkeys against Lethal Ebola Virus Infection
SO MBIO
LA English
DT Article
ID STAT1
AB Ebola viruses (EBOV) cause severe disease in humans and nonhuman primates with high mortality rates and continue to emerge in new geographic locations, including several countries in West Africa, the site of a large ongoing outbreak. Phosphorodiamidate morpholino oligomers (PMOs) are synthetic antisense molecules that are able to target mRNAs in a sequence-specific fashion and suppress translation through steric hindrance. We previously showed that the use of PMOs targeting a combination of VP35 and VP24 protected rhesus monkeys from lethal EBOV infection. Surprisingly, the present study revealed that a PMOplus compound targeting VP24 alone was sufficient to confer protection from lethal EBOV infection but that a PMOplus targeting VP35 alone resulted in no protection. This study further substantiates recent data demonstrating that VP24 may be a key virulence factor encoded by EBOV and suggests that VP24 is a promising target for the development of effective anti-EBOV countermeasures.
IMPORTANCE Several West African countries are currently being ravaged by an outbreak of Ebola virus (EBOV) that has become a major epidemic affecting not only these African countries but also Europe and the United States. A better understanding of the mechanism of virulence of EBOV is important for the development of effective treatments, as no licensed treatments or vaccines for EBOV disease are currently available. This study of phosphorodiamidate morpholino oligomers (PMOs) targeting the mRNAs of two different EBOV proteins, alone and in combination, demonstrated that targeting a single protein was effective at conferring a significant survival benefit in an EBOV lethal primate model. Future development of PMOs with efficacy against EBOV will be simplified if only one PMO is required instead of a combination, particularly in terms of regulatory approval.
C1 [Warren, Travis K.; Whitehouse, Chris A.; Wells, Jay; Welch, Lisa; Reid, St Patrick; Bavari, Sina] US Army Med Res Inst Infect Dis, Mol & Translat Sci Div, Ft Detrick, MD 21702 USA.
[Heald, Alison E.; Charleston, Jay S.; Sazani, Pete; Iversen, Patrick L.] Sarepta Therapeut Inc, Cambridge, MA USA.
[Heald, Alison E.] Univ Washington, Seattle, WA 98195 USA.
[Iversen, Patrick L.] Oregon State Univ, Corvallis, OR 97331 USA.
RP Bavari, S (reprint author), US Army Med Res Inst Infect Dis, Mol & Translat Sci Div, Ft Detrick, MD 21702 USA.
EM sina.bavari.civ@mail.mil
FU Joint Product Management Office of BioDefense Therapeutics (BD-Tx)
[W9113M-10-C-0056]
FX This work was conducted under a contract (W9113M-10-C-0056) with the
Joint Product Management Office of BioDefense Therapeutics (BD-Tx).
BD-Tx is a component of the Medical Countermeasure Systems Joint Project
Management Office (JPM-MCS) within the U.S. Department of Defense's
Joint Program Executive Office for Chemical and Biological Defense.
NR 16
TC 17
Z9 17
U1 2
U2 9
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 2150-7511
J9 MBIO
JI mBio
PD JAN-FEB
PY 2015
VL 6
IS 1
AR e02344-14
DI 10.1128/mBio.02344-14
PG 4
WC Microbiology
SC Microbiology
GA CC8PZ
UT WOS:000350631900003
ER
PT J
AU Thakur, GS
Daigle, BJ
Dean, KR
Zhang, YY
Rodriguez-Fernandez, M
Hammamieh, R
Yang, R
Jett, M
Palma, J
Petzold, LR
Doyle, FJ
AF Thakur, Gunjan S.
Daigle, Bernie J., Jr.
Dean, Kelsey R.
Zhang, Yuanyang
Rodriguez-Fernandez, Maria
Hammamieh, Rasha
Yang, Ruoting
Jett, Marti
Palma, Joseph
Petzold, Linda R.
Doyle, Francis J., III
TI Systems biology approach to understanding post-traumatic stress disorder
SO MOLECULAR BIOSYSTEMS
LA English
DT Review
ID ANTERIOR CINGULATE CORTEX; MEDIAL PREFRONTAL CORTEX; BREAST-CANCER
METASTASIS; GENE NETWORK INFERENCE; DNA METHYLATION; HIPPOCAMPAL VOLUME;
BIOMARKER IDENTIFICATION; MICROARRAY EXPERIMENTS; EXPRESSION PROFILES;
PERIPHERAL-BLOOD
AB Post-traumatic stress disorder (PTSD) is a psychological disorder affecting individuals that have experienced life-changing traumatic events. The symptoms of PTSD experienced by these subjects-including acute anxiety, flashbacks, and hyper-arousal-disrupt their normal functioning. Although PTSD is still categorized as a psychological disorder, recent years have witnessed a multi-directional research effort attempting to understand the biomolecular origins of the disorder. This review begins by providing a brief overview of the known biological underpinnings of the disorder resulting from studies using structural and functional neuroimaging, endocrinology, and genetic and epigenetic assays. Next, we discuss the systems biology approach, which is often used to gain mechanistic insights from the wealth of available high-throughput experimental data. Finally, we provide an overview of the current computational tools used to decipher the heterogeneous types of molecular data collected in the study of PTSD.
C1 [Thakur, Gunjan S.; Daigle, Bernie J., Jr.; Dean, Kelsey R.; Rodriguez-Fernandez, Maria; Palma, Joseph; Doyle, Francis J., III] Univ Calif Santa Barbara, Inst Collaborat Biotechnol, Santa Barbara, CA 93106 USA.
[Thakur, Gunjan S.; Dean, Kelsey R.; Rodriguez-Fernandez, Maria; Petzold, Linda R.; Doyle, Francis J., III] Univ Calif Santa Barbara, Dept Chem Engn, Santa Barbara, CA 93106 USA.
[Zhang, Yuanyang] Univ Calif Santa Barbara, Dept Comp Sci, Santa Barbara, CA 93106 USA.
[Hammamieh, Rasha; Yang, Ruoting; Jett, Marti; Palma, Joseph] US Army, Ctr Environm Hlth Res, Ft Detrick, MD USA.
[Petzold, Linda R.] Univ Calif Santa Barbara, Dept Mech Engn, Santa Barbara, CA 93106 USA.
RP Doyle, FJ (reprint author), Univ Calif Santa Barbara, Inst Collaborat Biotechnol, Santa Barbara, CA 93106 USA.
EM doyle@engineering.ucsb.edu
RI Rodriguez-Fernandez, Maria/I-7193-2016; Zhang, Yuanyang/S-8815-2016
OI Rodriguez-Fernandez, Maria/0000-0003-1966-2920; Zhang,
Yuanyang/0000-0002-5901-4242
FU institute for Collaborative Biotechnologies through grant from the US
Army research office [W911NF-10-2-0111]; USAMRMC [09284002]
FX This work was supported in part by the institute for Collaborative
Biotechnologies through grant from the US Army research office
(W911NF-10-2-0111) and the grant from USAMRMC (09284002).
NR 150
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U1 17
U2 38
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 1742-206X
EI 1742-2051
J9 MOL BIOSYST
JI Mol. Biosyst.
PY 2015
VL 11
IS 4
BP 980
EP 993
DI 10.1039/c4mb00404c
PG 14
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA CE0KQ
UT WOS:000351493300001
PM 25627823
ER
PT J
AU Gosch, NJC
Miller, ML
Gemeinhardt, TR
Sampson, SJ
Bonneau, JL
AF Gosch, Nathan J. C.
Miller, Marcus L.
Gemeinhardt, Todd R.
Sampson, Schuyler J.
Bonneau, Joseph L.
TI Age-0 Sturgeon Accessibility to Constructed and Modified Chutes in the
Lower Missouri River
SO NORTH AMERICAN JOURNAL OF FISHERIES MANAGEMENT
LA English
DT Article
ID PALLID STURGEON; SHOVELNOSE STURGEON; LARVAE
AB Shallow-water habitat is hypothesized to provide nursery habitat for young fish. The construction of side-channel chutes to restore shallow-water habitat is common in the lower Missouri River; however, a recent adaptive management strategy document (developed by a multiagency, multidiscipline team), as well as previous research, has suggested that the accessibility of chutes to age-0 Scaphirhynchus spp. (sturgeon hereafter) may be limited. Access is a critical prerequisite for young fish utilizing chute habitat; thus, we investigated chute-specific accessibility for age-0 sturgeon at seven chutes (constructed and natural). Age-0 sturgeon were capable of accessing most chutes; however, accessibility appeared limited at sites with highly restrictive inlet structures. Our results suggest that future consideration of chute inlet designs that meet authorized Missouri River purposes while providing improved fish access is warranted. Additionally, capture sites for exogenously feeding age-0 sturgeon were usually deeper (> 1.5 m) and faster (> 0.5 m/s) than sites without sturgeon in chute and adjacent main-stem habitats. This finding is consistent with previous research that suggests that slow and shallow habitats may not be used by age-0 sturgeon as frequently as other habitat types in the lower Missouri River.
C1 [Gosch, Nathan J. C.; Miller, Marcus L.; Gemeinhardt, Todd R.] US Army Corps Engineers, Environm Resources Sect, Kansas City, MO 64106 USA.
[Sampson, Schuyler J.] Nebraska Game & Pk Commiss, Lincoln, NE 68503 USA.
[Bonneau, Joseph L.] US Army Corps Engineers, Threatened & Endangered Species Sect, Yankton, SD 57078 USA.
RP Gosch, NJC (reprint author), US Army Corps Engineers, Environm Resources Sect, 601 East 12th St, Kansas City, MO 64106 USA.
EM nathan.j.gosch@usace.army.mil
FU U.S. Army Corps of Engineers Kansas City District
FX We thank Anthony Civiello, Kevin Montemayor, Jerrod Hall, and Ken
Hatten, as well as numerous other U.S. Army Corps of Engineers and
Nebraska Game and Parks Commission staff for field assistance. Michael
Chapman, Daniel Pridal, Tim Welker, and Heather Hill provided valuable
comments on an earlier draft of this manuscript. This study was funded
by the U.S. Army Corps of Engineers Kansas City District. The contents
of this report are not to be used for advertising, publication, or
promotional purposes. Reference to trade names does not imply
endorsement by the U.S. Government. All product names and trademarks
cited are the property of their respective owners. The findings of this
report are not to be construed as an official Department of Army
position unless so designated by other authorized documents.
NR 25
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U1 1
U2 6
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0275-5947
EI 1548-8675
J9 N AM J FISH MANAGE
JI North Am. J. Fish Manage.
PY 2015
VL 35
IS 1
BP 75
EP 85
DI 10.1080/02755947.2014.975300
PG 11
WC Fisheries
SC Fisheries
GA CD9VN
UT WOS:000351447600007
ER
PT B
AU Baird, S
AF Baird, Shannon
BE Schinke, RJ
McGannon, KR
TI BE, KNOW, DO model of consulting An exploration of how experiences with
soldiers affected me and how my notions of self affected soldiers'
experiences
SO PSYCHOLOGY OF SUB-CULTURE IN SPORT AND PHYSICAL ACTIVITY: CRITICAL
PERSPECTIVES
SE International Perspectives on Key Issues in Sport and Exercise
Psychology
LA English
DT Article; Book Chapter
ID PSYCHOLOGY SERVICE DELIVERY; APPLIED SPORT PSYCHOLOGY; REFLECTIVE
PRACTICE; EXERCISE PSYCHOLOGY
C1 US Army, Washington, DC 20310 USA.
RP Baird, S (reprint author), US Army, Washington, DC 20310 USA.
NR 36
TC 0
Z9 0
U1 0
U2 0
PU ROUTLEDGE
PI ABINGDON
PA 2 PARK SQ, MILTON PARK, ABINGDON OX14 4RN, OXFORD, ENGLAND
BN 978-1-84872-158-6; 978-1-315-77849-5; 978-1-84872-157-9
J9 INT PER KEY ISS SPO
PY 2015
BP 135
EP 152
PG 18
WC Hospitality, Leisure, Sport & Tourism; Psychology, Multidisciplinary
SC Social Sciences - Other Topics; Psychology
GA BC1HX
UT WOS:000350119300011
ER
PT J
AU Giri, L
Mallick, G
Jackson, AC
Griep, MH
Karna, SP
AF Giri, L.
Mallick, G.
Jackson, A. C.
Griep, M. H.
Karna, S. P.
TI Synthesis and characterization of high-purity, single phase hexagonal
Bi2Te3 nanostructures
SO RSC ADVANCES
LA English
DT Article
ID BISMUTH TELLURIDE; THERMOELECTRIC-MATERIALS; TOPOLOGICAL INSULATORS;
RAMAN-SPECTROSCOPY; NANOPARTICLES; MORPHOLOGY; NANOSHEETS; THICKNESS;
FILMS
AB In order to synthesize defect free, highly crystalline single phase nanostructured bismuth chalcogenides, we have investigated the effects of several reaction conditions including, solvents, temperatures, reaction time, and reducing agents. A small variation in the reaction method resulted in Bi2Te3 with different morphologies, ranging from nanosize particles, rods, platelets, and tubes to nanosheets. The materials were characterized by powder X-ray crystallography, scanning electron microscopy, transmission electron microscopy, energy dispersive X-ray analysis, Raman spectroscopy, and four-probe current (I)voltage (V) analysis. An optimized reaction condition allowed the synthesis of single-phase, impurity-free hexagonal nanoplates with size varying between 50 nm and 500 nm and thickness varying between 45 nm and 55 nm in a reproducible manner. The Raman spectra of the optimized hexagonal plates and sheets showed infra red (IR)-active modes around 118 cm(-1) resulting from symmetry breaking, a characteristic feature of nanostructured Bi2Te3. Additional peaks at 94 cm(-1) in the nanosheets, resulting from the surface phonon mode further confirmed the ultrathin Bi2Te3 structures. The I-V measurements on the optimized surface showed an n-type semiconducting behavior. The surface current measured as a function of applied voltage is two orders of magnitude higher than that across the stacked pellet in ambient conditions and much higher compared to previously published data on few quintuplet-thick Bi2Te3 nanofilms. The highlights of this study are the optimal solvothermic reaction conditions and their impact on obtaining defect free, highly crystalline single phase bismuth chalcogenides.
C1 [Giri, L.; Mallick, G.; Griep, M. H.; Karna, S. P.] US Army Res Lab, WMRD, Aberdeen Proving Ground, MD 21005 USA.
[Jackson, A. C.] Axalta Coating Syst, Wilmington, DE 19803 USA.
RP Karna, SP (reprint author), US Army Res Lab, WMRD, Aberdeen Proving Ground, MD 21005 USA.
EM shashi.p.karna.civ@mail.mil
FU U.S. Army Research Laboratory (US ARL)
FX This research by one of us (L. G.) was supported in part by an
appointment to the Research Participation Program at the U.S. Army
Research Laboratory (US ARL) administered by the Oak Ridge Institute for
Science and Education through an inter agency agreement between the U.S.
Department of Energy and US ARL. Fruitful discussions with Kate Duncan
are gratefully acknowledged.
NR 36
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U1 7
U2 36
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 2046-2069
J9 RSC ADV
JI RSC Adv.
PY 2015
VL 5
IS 32
BP 24930
EP 24935
DI 10.1039/c5ra02303c
PG 6
WC Chemistry, Multidisciplinary
SC Chemistry
GA CD8OE
UT WOS:000351354000016
ER
PT J
AU Crouse, LCB
Lent, EM
Leach, GJ
AF Crouse, Lee C. B.
Lent, Emily May
Leach, Glenn J.
TI Oral Toxicity of 3-Nitro-1,2,4-triazol-5-one in Rats
SO INTERNATIONAL JOURNAL OF TOXICOLOGY
LA English
DT Article
DE 3-nitro-1; 2; 4-triazole-5-one; NTO; oral toxicity; FOB; testicular
toxicity; benchmark dose; rat
ID SUBCHRONIC TOXICITY; FISCHER-344 RATS; C-14-LABELED
5-NITRO-1,2,4-TRIAZOL-3-ONE; TESTICULAR TOXICITY; TRIAZOLE FUNGICIDE;
LIVER MICROSOMES; METABOLISM; 1,3,5-TRINITROBENZENE; TEBUCONAZOLE;
EXPOSURE
AB 3-Nitro-1,2,4-triazol-5-one (NTO), an insensitive explosive, was evaluated to assess potential environmental and human health effects. A 14-day oral toxicity study in Sprague-Dawley rats was conducted with NTO in polyethylene glycol -200 by gavage at doses of 0, 250, 500, 1000, 1500, or 2000 mg/kg-d. Body mass and food consumption decreased in males (2000 mg/kg-d), and testes mass was reduced at doses of 500 mg/kg-d and greater. Based on the findings in the 14-day study, a 90-day study was conducted at doses of 0, 30, 100, 315, or 1000 mg/kg-d NTO. There was no effect on food consumption, body mass, or neurobehavioral parameters. Males in the 315 and 1000 mg/kg-d groups had reduced testes mass with associated tubular degeneration and atrophy. The testicular effects were the most sensitive adverse effect and were used to derive a benchmark dose (BMD) of 70 mg/kg-d with a 10% effect level (BMDL10) of 40 mg/kg-d.
C1 [Crouse, Lee C. B.; Lent, Emily May; Leach, Glenn J.] US Army Publ Hlth Command, Army Inst Publ Hlth, Aberdeen Proving Ground, MD 21010 USA.
RP Crouse, LCB (reprint author), US Army Publ Hlth Command, Army Inst Publ Hlth, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA.
EM lee.crouse.civ@mail.mil
FU U.S. Army Armament Research, Development, and Engineering Center (MIPR)
[MIPR8FGM009485]
FX The author(s) disclose receipt of the following financial support for
the research, authorship, and/or publication of this article: funded by
the U.S. Army Armament Research, Development, and Engineering Center
(MIPR number MIPR8FGM009485, 2008).
NR 39
TC 6
Z9 6
U1 1
U2 15
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1091-5818
EI 1092-874X
J9 INT J TOXICOL
JI Int. J. Toxicol.
PD JAN-FEB
PY 2015
VL 34
IS 1
BP 55
EP 66
DI 10.1177/1091581814567177
PG 12
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA CB9WZ
UT WOS:000349986200008
PM 25589095
ER
PT J
AU Ridderhoff, KJ
Hull, JR
Sandberg, SK
AF Ridderhoff, Kevin J.
Hull, Jessica R.
Sandberg, Sheila K.
TI Blanchfield Army Community Hospital Polypharmacy Clinic
SO JOURNAL OF MANAGED CARE PHARMACY
LA English
DT Editorial Material
AB The increased use of central nervous system depressants (CNSD) and psychotropics are one of the many factors that contribute to suicidal behavior in soldiers. U.S. Army policy requires medication screening for any soldier prescribed 4 or more medications when at least 1 of the medications is a CNSD or psychotropic. Constant deployments challenged health care provider ability to comply with required screenings, and senior leaders sought proactive intervention to reduce medication risks upon return of the 101st Airborne Division (Air Assault) from deployment in 2011.
A pharmacy-led team established the Polypharmacy Clinic (PC) at Blanchfield Army Community Hospital. Of the 3,999 soldiers assigned, 540 (13.5%) met the initial screening criteria. Success of the pilot program led to the mandatory screening of all other Fort Campbell, Kentucky, brigades. During the first 12 months, 895 soldiers were seen by a clinical pharmacist, and 1,574 interventions were documented. Significant interventions included medication added (121), medication changed (258), medication stopped (164), lab monitoring recommended (172), adverse reaction mitigated (41), therapeutic duplication prevented (61), and drug-drug interaction identified (93). Additionally, 55 soldiers were recommended for temporary duty profiles based on their adverse drug effects. Ten soldiers were recommended for enhanced controlled substance monitoring.
Placing soldiers on clinically appropriate medications and removing potentially harmful medications from their possession are examples of how the PC positively impacted the Commanding General's ability to deploy a fully medically ready force. Soldiers consistently remarked favorably on the thorough medication counseling provided at their PC appointments. Innovative notes within the electronic health record summarized relevant findings regarding soldiers' medications, which allowed providers to quickly pinpoint and adjust medication regimens. With each identified high-risk soldier, we decreased the potential for postdeployment medication issues. Additionally, the PC generated over $70,000 in relative value units for the hospital. Copyright (C) 2015, Academy of Managed Care Pharmacy. All rights reserved.
C1 [Ridderhoff, Kevin J.] Def Hlth Agcy, Pharm Operat Div, Formulary Management Branch, Falls Church, VA 22042 USA.
[Hull, Jessica R.] Womack Army Med Ctr, Clin Pharm, Ft Bragg, NC USA.
RP Ridderhoff, KJ (reprint author), Def Hlth Agcy, Pharm Operat Div, 7700 Arlington Blvd,Ste 501, Falls Church, VA 22042 USA.
EM kevin.ridderhoff@dha.mil
NR 7
TC 0
Z9 0
U1 1
U2 1
PU ACAD MANAGED CARE PHARMACY
PI ALEXANDRIA
PA 100 N PITT ST, 400, ALEXANDRIA, VA 22314-3134 USA
SN 1083-4087
J9 J MANAGE CARE PHARM
JI J. Manag. Care Pharm.
PD JAN
PY 2015
VL 21
IS 1
BP 8
EP 11
PG 4
WC Health Care Sciences & Services; Pharmacology & Pharmacy
SC Health Care Sciences & Services; Pharmacology & Pharmacy
GA CC8KP
UT WOS:000350617900001
PM 25562768
ER
PT J
AU Scheuermann, E
Costello, M
Silton, S
Sahu, J
AF Scheuermann, Edward
Costello, Mark
Silton, Sidra
Sahu, Jubaraj
TI Aerodynamic Characterization of a Microspoiler System for Supersonic
Finned Projectiles
SO JOURNAL OF SPACECRAFT AND ROCKETS
LA English
DT Article
ID PREDICTION
AB To create highly maneuverable projectiles, some physical control mechanism is needed that is capable of altering the projectile trajectory in a desired manner. The work reported here considers a small flow control device, termed a microspoiler system, located between the rear stabilizing fins of a projectile. Such a mechanism relies on the boundary-layer shock interaction between the projectile body, rear stabilizing fins, and microspoilers to provide a multiplicative effect on controllable forces and moments. To investigate performance of the microspoiler control mechanism, projectile trajectories with microspoilers were generated both computationally using a coupled CFD and rigid-body dynamic simulation and experimentally from spark range testing. Using this computational and experimental trajectory information, aerodynamic coefficients both with and without microspoilers were estimated and found to be in good agreement where the major effect of the microspoiler system is the addition of trim forces and moments along with a slight increase in axial forces. Additionally, control authority of a basic finned projectile equipped with an active microspoiler system is investigated for a typical direct-fire shooting scenario.
C1 [Scheuermann, Edward] Georgia Inst Technol, Woodruff Sch Mech Engn, Atlanta, GA 30332 USA.
[Costello, Mark] Georgia Inst Technol, Woodruff Sch Mech Engn, Guggenheim Sch Aerosp Engn, Atlanta, GA 30332 USA.
[Silton, Sidra; Sahu, Jubaraj] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen, MD 21005 USA.
RP Scheuermann, E (reprint author), Georgia Inst Technol, Woodruff Sch Mech Engn, Atlanta, GA 30332 USA.
NR 13
TC 2
Z9 2
U1 3
U2 6
PU AMER INST AERONAUTICS ASTRONAUTICS
PI RESTON
PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA
SN 0022-4650
EI 1533-6794
J9 J SPACECRAFT ROCKETS
JI J. Spacecr. Rockets
PD JAN-FEB
PY 2015
VL 52
IS 1
BP 253
EP 263
DI 10.2514/1.A33005
PG 11
WC Engineering, Aerospace
SC Engineering
GA CD2CP
UT WOS:000350881800023
ER
PT J
AU Fleischmann, C
Gopez, J
Lundberg, P
Ritter, H
Killops, KL
Hawker, CJ
Klinger, D
AF Fleischmann, Carolin
Gopez, Jeffrey
Lundberg, Pontus
Ritter, Helmut
Killops, Kato L.
Hawker, Craig J.
Klinger, Daniel
TI A robust platform for functional microgels via thiol-ene chemistry with
reactive polyether-based nanoparticles
SO POLYMER CHEMISTRY
LA English
DT Article
ID DRUG-DELIVERY APPLICATIONS; LIGHT-INDUCED DEGRADATION;
STIMULI-RESPONSIVE MICROGELS; CLICK CHEMISTRY; MINIEMULSION
POLYMERIZATION; THERMORESPONSIVE MICROGELS; SWELLING RESPONSE; IONIC
MICROGELS; ACID) MICROGELS; CROSS-LINKERS
AB We herein report the development of crosslinked polyether particles as a reactive platform for the preparation of functional microgels. Thiol-ene crosslinking of poly(allyl glycidyl ether) in miniemulsion droplets -stabilized by a surface active, bio-compatible polyethylene glycol block copolymer -resulted in colloidal gels with a PEG corona and an inner polymeric network containing reactive allyl units. The stability of the allyl groups allows the microgels to be purified and stored before a second, subsequent thiol-ene functionalization step allows a wide variety of pH-and chemically-responsive groups to be introduced into the nanoparticles. The facile nature of this synthetic platform enables the preparation of microgel libraries that are responsive to different triggers but are characterized by the same size distribution, surface functionality, and crosslinking density. In addition, the utilization of a crosslinker containing cleavable ester groups renders the resulting hydrogel particles degradable at elevated pH or in the presence of esterase under physiological conditions.
C1 [Fleischmann, Carolin; Ritter, Helmut] Univ Dusseldorf, Inst Organ Chem & Makromol Chem, D-40225 Dusseldorf, Germany.
[Fleischmann, Carolin; Gopez, Jeffrey; Lundberg, Pontus; Hawker, Craig J.; Klinger, Daniel] Dept Chem & Biochem, Mat Res Lab, Santa Barbara, CA 93106 USA.
[Fleischmann, Carolin; Gopez, Jeffrey; Lundberg, Pontus; Hawker, Craig J.; Klinger, Daniel] Dept Mat, Santa Barbara, CA 93106 USA.
[Killops, Kato L.] US Army Res Dev & Engn Command, Edgewood Chem Biol Ctr, Proving Ground, MD 21010 USA.
RP Hawker, CJ (reprint author), Dept Chem & Biochem, Mat Res Lab, Santa Barbara, CA 93106 USA.
EM hawker@mrl.ucsb.edu; klinger@mrl.ucsb.edu
FU U.S. Army Research Office [W911NF-09-0001]; U.S. Army Basic Research
Program and Edgewood Chemical Biological Center; National Heart, Lung,
and Blood Institute, National Institutes of Health, Department of Health
and Human Services [HHSN268201000046C]; Wenner-Gren foundations; Bengt
Lundqvist memorial foundation; MRSEC Program of the National Science
Foundation [DMR 1121053]
FX This work was supported by the Institute for Collaborative
Biotechnologies through grant W911NF-09-0001 from the U.S. Army Research
Office (D. K. and C. J. H.), the U.S. Army Basic Research Program and
Edgewood Chemical Biological Center (K.L.K.), and the National Heart,
Lung, and Blood Institute, National Institutes of Health, Department of
Health and Human Services, under Contract no. HHSN268201000046C (D. K.,
and C. J. H.). The content of the information does not necessarily
reflect the position or the policy of the Government, and no official
endorsement should be inferred. P. L. would like to thank the
Wenner-Gren foundations and Bengt Lundqvist memorial foundation for
financial support. Characterization work was enabled by MRL Central
Facilities supported by the MRSEC Program of the National Science
Foundation under Award no. DMR 1121053 (C. F., J. G. and P. L.).
NR 66
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Z9 4
U1 10
U2 70
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 1759-9954
EI 1759-9962
J9 POLYM CHEM-UK
JI Polym. Chem.
PY 2015
VL 6
IS 11
BP 2029
EP 2037
DI 10.1039/c4py01766h
PG 9
WC Polymer Science
SC Polymer Science
GA CC8TY
UT WOS:000350642400016
PM 26005499
ER
PT J
AU Reiter, MJ
Schwope, RB
Kini, JA
York, GE
Suhr, AW
AF Reiter, Michael J.
Schwope, Ryan B.
Kini, Jonathan A.
York, Gerald E.
Suhr, Abraham W.
TI Postoperative Imaging of the Orbital Contents
SO RADIOGRAPHICS
LA English
DT Article
ID GLAUCOMA DRAINAGE IMPLANTS; INTRAOCULAR-LENS IMPLANTS;
COMPUTED-TOMOGRAPHY; EYELID WEIGHTS; UNITED-STATES; SILICONE OIL; MR;
CT; APPEARANCE; DEVICES
AB Ophthalmologists perform a wide array of interventions on the orbital contents. The surgical treatment of glaucoma, cataracts, retinal detachment, and ocular trauma or malignancy results in alteration of the standard anatomy, which is often readily evident at radiologic examinations. The ability to accurately recognize the various imaging manifestations after orbital surgery is critical for radiologists to avoid misdiagnosis. Of particular importance is familiarity with the numerous types of implanted devices, such as glaucoma drainage devices, orbital implants, and eyelid weights. Although knowledge of patients' surgical history is helpful, this information is often not available at the time of interpretation. Fortunately, there are characteristic posttreatment findings that enable diagnosis. The imaging features of the most commonly performed ophthalmologic procedures are highlighted, with emphasis on computed tomography and magnetic resonance ( MR) imaging, because they are currently the primary modalities involved in evaluating the orbits. Glaucoma drainage devices and orbital implants after enucleation are two of the more pertinent implanted devices because their composition has substantially evolved over the past 2 decades, which affects their imaging appearance. Some devices, such as the Baerveldt Glaucoma Implant and platinum-weighted eyelid implants, may distort radiologic images. The MR imaging safety profiles of numerous implanted devices are also reported. (C) RSNA, 2015 . radiographics. rsna. org
C1 [Reiter, Michael J.; Schwope, Ryan B.; Kini, Jonathan A.; York, Gerald E.] Brooke Army Med Ctr, Dept Radiol, San Antonio, TX 78234 USA.
[Suhr, Abraham W.] Brooke Army Med Ctr, Dept Ophthalmol, San Antonio, TX 78234 USA.
RP Reiter, MJ (reprint author), Brooke Army Med Ctr, Dept Radiol, 3851 Roger Brooke Dr, San Antonio, TX 78234 USA.
EM mikereiter13@yahoo.com
NR 45
TC 1
Z9 1
U1 0
U2 3
PU RADIOLOGICAL SOC NORTH AMERICA
PI OAK BROOK
PA 820 JORIE BLVD, OAK BROOK, IL 60523 USA
SN 0271-5333
J9 RADIOGRAPHICS
JI Radiographics
PD JAN-FEB
PY 2015
VL 35
IS 1
BP 221
EP 234
DI 10.1148/rg.351140008
PG 14
WC Radiology, Nuclear Medicine & Medical Imaging
SC Radiology, Nuclear Medicine & Medical Imaging
GA CD0FF
UT WOS:000350745300016
PM 25590399
ER
PT J
AU Wildman, RA
Gazonas, GA
AF Wildman, Raymond A.
Gazonas, George A.
TI Multiobjective topology optimization of energy absorbing materials
SO STRUCTURAL AND MULTIDISCIPLINARY OPTIMIZATION
LA English
DT Article
DE Topology optimization; Pareto optimization; Genetic programming; Energy
absorbing material
ID CONSTRUCTIVE SOLID GEOMETRY; COUPLED MULTISCALE MODEL; HYBRID
CELLULAR-AUTOMATA; GENETIC ALGORITHM; NUMERICAL SIMULATIONS; INVERSE
SCATTERING; CRACK-GROWTH; LEVEL SET; DESIGN; MICROSTRUCTURES
AB A method for the multiobjective optimization of local-scale material topology is presented. The topology optimization scheme is based on a constructive solid geometry-like representation, in which convex polygons-defined as the convex hull of arbitrary-length lists of points-are combined using an overlapping function. This data structure is tree-shaped and so genetic programming is used as the optimizer. The forward problem is solved with a multiscale finite element method with automatic cohesive zone insertion to model damage. As a multiscale method, loads and boundary conditions are applied and objective functions measured at a global scale, while the local scale material structure is optimized. The global scale geometry is assumed fixed. Pareto optimal designs are generated, representing optimal tradeoffs between conflicting goals: quasi-static displacement and dynamic strain energy. Results demonstrate the efficacy of the proposed algorithm.
C1 [Wildman, Raymond A.; Gazonas, George A.] US Army Res Lab, Attn RDRL WMM B, Aberdeen Proving Ground, MD 21005 USA.
RP Wildman, RA (reprint author), US Army Res Lab, Attn RDRL WMM B, Aberdeen Proving Ground, MD 21005 USA.
EM raymond.a.wildman.civ@mail.mil
OI Gazonas, George/0000-0002-2715-016X
FU Department of Defense High Performance Computing Modernization Program
(HPCMP) Challenge Project [ARLAP02331C5V]
FX This research was supported by grants of computer time and resources on
HPC systems under the Department of Defense High Performance Computing
Modernization Program (HPCMP) Challenge Project ARLAP02331C5V.
NR 50
TC 1
Z9 1
U1 10
U2 25
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1615-147X
EI 1615-1488
J9 STRUCT MULTIDISCIP O
JI Struct. Multidiscip. Optim.
PD JAN
PY 2015
VL 51
IS 1
BP 125
EP 143
DI 10.1007/s00158-014-1117-8
PG 19
WC Computer Science, Interdisciplinary Applications; Engineering,
Multidisciplinary; Mechanics
SC Computer Science; Engineering; Mechanics
GA CD2HM
UT WOS:000350896500008
ER
PT S
AU Akers, KS
Cardile, AP
Wenke, JC
Murray, CK
AF Akers, Kevin S.
Cardile, Anthony P.
Wenke, Joseph C.
Murray, Clinton K.
BE Donelli, G
TI Biofilm Formation by Clinical Isolates and Its Relevance to Clinical
Infections
SO BIOFILM-BASED HEALTHCARE-ASSOCIATED INFECTIONS, VOL I
SE Advances in Experimental Medicine and Biology
LA English
DT Article; Book Chapter
ID CANDIDA-PARAPSILOSIS COMPLEX; MYCOBACTERIUM-AVIUM COMPLEX;
STAPHYLOCOCCUS-AUREUS BIOFILM; FIBRONECTIN-BINDING PROTEINS;
CYSTIC-FIBROSIS PATIENTS; ENTEROAGGREGATIVE ESCHERICHIA-COLI; TOTAL KNEE
ARTHROPLASTY; PSEUDOMONAS-AERUGINOSA; IN-VITRO; CHRONIC RHINOSINUSITIS
AB Reports of biofilms have increased exponentially in the scientific literature over the past two decades, yet the vast majority of these are basic science investigations with limited clinical relevance. Biofilm studies involving clinical isolates are most often surveys of isolate collections, but suffer from lack of standardization in methodologies for producing and assessing biofilms. In contrast, more informative clinical studies correlating biofilm formation to patient data have infrequently been reported. In this chapter, biofilm surveys of clinical isolates of aerobic and anaerobic bacteria, mycobacteria, and Candida are reviewed, as well as those pertaining to the unique situation of cystic fibrosis. In addition, the influence of host components on in vitro biofilm formation, as well as published studies documenting the clinical impact of biofilms in human infections, are presented.
C1 [Akers, Kevin S.; Wenke, Joseph C.] US Army Inst Surg Res, Extrem Trauma & Regenerat Med Task Area, Houston, TX 78234 USA.
[Akers, Kevin S.; Cardile, Anthony P.; Murray, Clinton K.] Brooke Army Med Ctr, Infect Dis Serv, Houston, TX USA.
RP Akers, KS (reprint author), US Army Inst Surg Res, Extrem Trauma & Regenerat Med Task Area, Houston, TX 78234 USA.
EM kevin.s.akers.mil@mail.mil
NR 175
TC 6
Z9 6
U1 1
U2 17
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
SN 0065-2598
BN 978-3-319-11038-7; 978-3-319-11037-0
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2015
VL 830
BP 1
EP 28
DI 10.1007/978-3-319-11038-7_1
D2 10.1007/978-3-319-11038-7
PG 28
WC Infectious Diseases; Microbiology
SC Infectious Diseases; Microbiology
GA BC1SD
UT WOS:000350409600002
PM 25366218
ER
PT J
AU Choi, Y
AF Choi, Yong
TI Comment on: A case-matched study of the differences in bone mineral
density 1 year after 3 different bariatric procedures
SO SURGERY FOR OBESITY AND RELATED DISEASES
LA English
DT Editorial Material
ID SLEEVE GASTRECTOMY; GASTRIC BYPASS; SURGERY
C1 Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA.
RP Choi, Y (reprint author), Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA.
NR 5
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1550-7289
EI 1878-7533
J9 SURG OBES RELAT DIS
JI Surg. Obes. Relat. Dis.
PD JAN-FEB
PY 2015
VL 11
IS 1
BP 186
EP 186
PG 1
WC Surgery
SC Surgery
GA CC7FY
UT WOS:000350534300030
PM 25547058
ER
PT J
AU Bell, KR
Brockway, JA
Fann, JR
Cole, WR
De Lore, JS
Bush, N
Lang, AJ
Hart, T
Warren, M
Dikmen, S
Temkin, N
Jain, S
Raman, R
Stein, MB
AF Bell, Kathleen R.
Brockway, Jo Ann
Fann, Jesse R.
Cole, Wesley R.
De Lore, Jef St.
Bush, Nigel
Lang, Ariel J.
Hart, Tessa
Warren, Michael
Dikmen, Sureyya
Temkin, Nancy
Jain, Sonia
Raman, Rema
Stein, Murray B.
TI Concussion treatment after combat trauma: Development of a telephone
based, problem solving intervention for service members
SO CONTEMPORARY CLINICAL TRIALS
LA English
DT Article
DE Concussion; Brain Injury; Military; Problem solving training; Telephone
intervention; Telehealth
ID POSTTRAUMATIC-STRESS-DISORDER; RANDOMIZED CONTROLLED-TRIAL;
COGNITIVE-BEHAVIORAL THERAPY; IDENTIFICATION TEST AUDIT; BRAIN-INJURY;
MENTAL-HEALTH; PRIMARY-CARE; PSYCHOLOGICAL TREATMENT; 1ST YEAR;
DEPRESSION
AB Military service members (SMs) and veterans who sustain mild traumatic brain injuries (mTBI) during combat deployments often have co-morbid conditions but are reluctant to seek out therapy in medical or mental health settings. Efficacious methods of intervention that are patient-centered and adaptable to a mobile and often difficult-to-reach population would be useful in improving quality of life. This article describes a new protocol developed as part of a randomized clinical trial of a telephone-mediated program for SMs with mTBI. The 12-session program combines problem solving training (PST) with embedded modules targeting depression, anxiety, insomnia, and headache. The rationale and development of this behavioral intervention for implementation with persons with multiple co-morbidities is described along with the proposed analysis of results. In particular, we provide details regarding the creation of a treatment that is manualized yet flexible enough to address a wide variety of problems and symptoms within a standard framework. The methods involved in enrolling and retaining an often hard-to-study population are also highlighted. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Bell, Kathleen R.; Brockway, Jo Ann; Dikmen, Sureyya; Temkin, Nancy] Univ Washington, Dept Rehabil Med, Seattle, WA 98195 USA.
[Fann, Jesse R.] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA.
[Cole, Wesley R.] WAMC, Dept Brain Injury Med, Def & Vet Brain Injury Ctr, Ft Bragg, NC 28310 USA.
[De Lore, Jef St.; Dikmen, Sureyya; Temkin, Nancy] Univ Washington, Dept Neurol Surg, Seattle, WA 98104 USA.
[Bush, Nigel] Natl Ctr Telehlth & Technol, Tacoma, WA 98431 USA.
[Lang, Ariel J.; Stein, Murray B.] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA.
[Hart, Tessa] Moss Rehabil Res Inst, Elkins Pk, PA 19027 USA.
[Warren, Michael] Fielding Behav Hlth, Clin Psychol Doctoral Intern, Kirkland, WA 98034 USA.
[Temkin, Nancy] Univ Washington, Dept Biostat, Seattle, WA 98195 USA.
[Jain, Sonia; Raman, Rema; Stein, Murray B.] Univ Calif San Diego, Dept Family & Prevent Med, La Jolla, CA 92093 USA.
RP Bell, KR (reprint author), Univ Washington, Dept Rehabil Med, Box 356490,1959 NE Pacific St, Seattle, WA 98195 USA.
EM Icrbell@uw.edu; brockja@uw.edu; fann@uw.edu; wesley.r.cole.ctr@mail.mil;
saint@uw.edu; nigel.e.bush.civ@mail.mil; ajlang@ucsd.edu;
thart@einstein.edu; mwarren@email.fielding.edu; dilcmen@uw.edu;
temIdn@uw.edu; sojain@ucsd.edu; reraman@ucsd.edu; mstein@ucsd.edu
FU U.S. Army Medical Research and Materiel Command (USAMRMC)
[W81XWH-08-2-0159]; National Institute on Disability and Rehabilitation
Research [H133G070143]
FX The research reported in this article was supported by the U.S. Army
Medical Research and Materiel Command (USAMRMC), USAMRMC Funding
Mechanism: Contract# W81XWH-08-2-0159. Supplemental funding for
development of the treatment manual and fidelity assessment system was
provided by the National Institute on Disability and Rehabilitation
Research, grant # H133G070143.
NR 67
TC 4
Z9 4
U1 8
U2 14
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1551-7144
EI 1559-2030
J9 CONTEMP CLIN TRIALS
JI Contemp. Clin. Trials
PD JAN
PY 2015
VL 40
BP 54
EP 62
DI 10.1016/j.cct.2014.11.001
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA CB6IZ
UT WOS:000349732000007
PM 25460344
ER
PT B
AU Bin, Y
AF Bin, Yu
BE Dutkiewicz, P
Sakwa, R
TI The Shanghai Cooperation Organisation, China and Eurasian integration
SO EURASIAN INTEGRATION - THE VIEW FROM WITHIN
SE Routledge Contemporary Russia and Eastern Europe Series
LA English
DT Article; Book Chapter
C1 [Bin, Yu] Wittenberg Univ, Springfield, OH 45504 USA.
[Bin, Yu] Ctr Strateg & Int Studies, Washington, DC 20006 USA.
RP Bin, Y (reprint author), US Army War Coll, SSI, Carlisle, PA 17013 USA.
NR 55
TC 0
Z9 0
U1 2
U2 3
PU ROUTLEDGE
PI ABINGDON
PA 2 PARK SQ, MILTON PARK, ABINGDON OX14 4RN, OXFORD, ENGLAND
BN 978-1-315-73815-4; 978-1-138-77897-9
J9 ROUTL CONTEMP RUSS E
PY 2015
VL 60
BP 256
EP 273
PG 18
WC International Relations; Political Science
SC International Relations; Government & Law
GA BB9SL
UT WOS:000348593100017
ER
PT J
AU Light, B
Dickinson, S
Perovich, DK
Holland, MM
AF Light, Bonnie
Dickinson, Suzanne
Perovich, Donald K.
Holland, Marika M.
TI Evolution of summer Arctic sea ice albedo in CCSM4 simulations: Episodic
summer snowfall and frozen summers
SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS
LA English
DT Article
DE Arctic sea ice; albedo; snow on sea ice; melt ponds
ID MELT PONDS; SURFACE ALBEDO; 28 YR; OCEAN; COVER; SHEBA; MODEL
AB The albedo of Arctic sea ice is calculated from summertime output of twentieth century Community Climate System Model v.4 (CCSM4) simulations. This is compared with an empirical record based on the generalized observations of the summer albedo progression along with melt onset dates determined from remote sensing. Only the contributions to albedo from ice, snow, and ponds are analyzed; fractional ice area is not considered in this assessment. Key factors dictating summer albedo evolution are the timing and extent of ponding and accumulation of snow. The CCSM4 summer sea ice albedo decline was found, on average, to be less pronounced than either the empirical record or the CLARA-SAL satellite record. The modeled ice albedo does not go as low as the empirical record, nor does the low summer albedo last as long. In the model, certain summers were found to retain snow on sea ice, thus inhibiting ice surface melt and the formation or retention of melt ponds. These frozen summers were generally not the summers with the largest spring snow accumulation, but were instead summers that received at least trace snowfall in June or July. When these frozen summers are omitted from the comparison, the model and empirical records are in much better agreement. This suggests that the representation of summer Arctic snowfall events and/or their influence on the sea ice conditions are not well represented in CCSM4 integrations, providing a target for future model development work.
C1 [Light, Bonnie; Dickinson, Suzanne] Univ Washington, Appl Phys Lab, Polar Sci Ctr, Seattle, WA 98105 USA.
[Perovich, Donald K.] US Army, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA.
[Holland, Marika M.] Natl Ctr Atmospher Res, Boulder, CO 80307 USA.
RP Light, B (reprint author), Univ Washington, Appl Phys Lab, Polar Sci Ctr, Seattle, WA 98105 USA.
EM bonnie@apl.washington.edu
FU NSF [ARC-0902040]; ONR [N00014-13-1-0296]
FX Data used to perform the analysis in this paper are available from The
Earth System Grid Gateway at the National Center for Atmospheric
Research. The CCSM4 data sets used were b40.20th.track1.1deg.012 and
b40.rcp2_6.1deg.006. The empirical record data are archived at ACADIS
(www.aoncadis.org/dataset/arctic_ocean_solar_heating.html). This work
was supported by NSF grant ARC-0902040 and ONR grant N00014-13-1-0296 to
the University of Washington. The authors thank Taryn Black for
programming support and Cecilia Bitz for insightful discussion. Comments
from two anonymous reviewers are also acknowledged for significantly
improving this manuscript.
NR 44
TC 3
Z9 3
U1 1
U2 11
PU AMER GEOPHYSICAL UNION
PI WASHINGTON
PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA
SN 2169-9275
EI 2169-9291
J9 J GEOPHYS RES-OCEANS
JI J. Geophys. Res.-Oceans
PD JAN
PY 2015
VL 120
IS 1
BP 284
EP 303
DI 10.1002/2014JC010149
PG 20
WC Oceanography
SC Oceanography
GA CB8OP
UT WOS:000349890000018
ER
PT J
AU Borodin, O
Han, SD
Daubert, JS
Seo, DM
Yun, SH
Henderson, WA
AF Borodin, Oleg
Han, Sang-Don
Daubert, James S.
Seo, Daniel M.
Yun, Sung-Hyun
Henderson, Wesley A.
TI Electrolyte Solvation and Ionic Association VI. Acetonitrile-Lithium
Salt Mixtures: Highly Associated Salts Revisited
SO JOURNAL OF THE ELECTROCHEMICAL SOCIETY
LA English
DT Article
ID N,N'-AROMATIC BIDENTATE LIGANDS; MOLECULAR-DYNAMICS SIMULATIONS;
AMORPHOUS CONCENTRATED LIQUID; LI+ CATION COORDINATION; POLYMER
ELECTROLYTES; CRYSTAL-STRUCTURES; LOCAL STRUCTURES; GROUP-1 SALTS; BASE
RATIO; COMPLEXES
AB Molecular dynamics (MD) simulations of acetonitrile (AN) mixtures with LiBF4, LiCF3SO3 and LiCF3CO2 provide extensive details about the molecular- and mesoscale-level solution interactions and thus explanations as to why these electrolytes have very different thermal phase behavior and electrochemical/physicochemical properties. The simulation results are in full accord with a previous experimental study of these (AN)(n)-LiX electrolytes. This computational study reveals how the structure of the anions strongly influences the ionic association tendency of the ions, the manner in which the aggregate solvates assemble in solution and the length of time in which the anions remain coordinated to the Li+ cations in the solvates which result in dramatic variations in the transport properties of the electrolytes. (C) The Author(s) 2015. Published by ECS. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License (CC BY, http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse of the work in any medium, provided the original work is properly cited. All rights reserved.
C1 [Borodin, Oleg] US Army Res Lab, Electrochem Branch, Adelphi, MD 20783 USA.
[Han, Sang-Don; Daubert, James S.; Seo, Daniel M.; Henderson, Wesley A.] N Carolina State Univ, Dept Chem & Biomol Engn, Ion Liquids & Electrolytes Energy Technol ILEET L, Raleigh, NC 27695 USA.
[Yun, Sung-Hyun] Gwangju Inst Sci & Technol, Sch Environm Sci & Engn, Kwangju 500712, South Korea.
[Henderson, Wesley A.] Pacific NW Natl Lab, Energy & Environm Directorate, Electrochem Mat & Syst EMS Grp, Richland, WA 99352 USA.
RP Borodin, O (reprint author), US Army Res Lab, Electrochem Branch, Adelphi, MD 20783 USA.
EM oleg.a.borodin.civ@mail.mil; Wesley.Henderson@pnnl.gov
RI Borodin, Oleg/B-6855-2012;
OI Borodin, Oleg/0000-0002-9428-5291; Daubert, James/0000-0002-8151-9191
FU Department of Energy [DE-IA01-11EE003413]; U.S. Army Research Laboratory
[DE-IA01-11EE003413]; U.S. Department of Energy, Office of Basic Energy
Sciences, Division of Materials Sciences and Engineering [DE-SC0002169]
FX The computational work was partially supported by an Interagency
Agreement between the U.S. Department of Energy and the U.S. Army
Research Laboratory under DE-IA01-11EE003413 for the Office of Vehicle
Technologies Programs including the Batteries for Advanced
Transportation Technologies (BATT) Program. The authors wish to also
express their gratitude to the U.S. Department of Energy, Office of
Basic Energy Sciences, Division of Materials Sciences and Engineering
which supported the evaluation of the computational work and preparation
of the manuscript under Award DE-SC0002169.
NR 41
TC 8
Z9 8
U1 3
U2 32
PU ELECTROCHEMICAL SOC INC
PI PENNINGTON
PA 65 SOUTH MAIN STREET, PENNINGTON, NJ 08534 USA
SN 0013-4651
EI 1945-7111
J9 J ELECTROCHEM SOC
JI J. Electrochem. Soc.
PY 2015
VL 162
IS 4
BP A501
EP A510
DI 10.1149/2.0891503jes
PG 10
WC Electrochemistry; Materials Science, Coatings & Films
SC Electrochemistry; Materials Science
GA CB7SG
UT WOS:000349827200002
ER
PT J
AU Song, HJ
Rosano, JM
Wang, Y
Garson, CJ
Prabhakarpandian, B
Pant, K
Klarmann, GJ
Perantoni, A
Alvarez, LM
Lai, E
AF Song, Hongjun
Rosano, Jenna M.
Wang, Yi
Garson, Charles J.
Prabhakarpandian, Balabhaskar
Pant, Kapil
Klarmann, George J.
Perantoni, Alan
Alvarez, Luis M.
Lai, Eva
TI Continuous-flow sorting of stem cells and differentiation products based
on dielectrophoresis
SO LAB ON A CHIP
LA English
DT Article
ID DIELECTRIC-PROPERTIES; CANCER-CELLS; BONE-MARROW; SEPARATION; BLOOD;
FRACTIONATION; ENRICHMENT; MICROELECTRODES; REMOVAL; THERAPY
AB This paper presents a continuous-flow microfluidic device for sorting stem cells and their differentiation progenies. The principle of the device is based on the accumulation of multiple dielectrophoresis (DEP) forces to deflect cells laterally in conjunction with the alternating on/off electric field to manipulate the cell trajectories. The microfluidic device containing a large array of oblique interdigitated electrodes was fabricated using a combination of standard and soft lithography techniques to generate a PDMS-gold electrode construct. Experimental testing with human mesenchymal stem cells (hMSC) and their differentiation progenies (osteoblasts) was carried out at different flow rates, and clear separation of the two populations was achieved. Most of the osteoblasts experiencing stronger DEP forces were deflected laterally and continuously, following zig-zag trajectories, and moved towards the desired collection outlet, whereas most of the hMSCs remained on the original trajectory due to weaker DEP forces. The experimental measurements were characterized and evaluated quantitatively, and consistent performance was demonstrated. Collection efficiency up to 92% and 67% for hMSCs and osteoblasts, respectively, along with purity up to 84% and 87% was obtained. The experimental results established the feasibility of our microfluidic DEP sorting device for continuous, label-free sorting of stem cells and their differentiation progenies.
C1 [Song, Hongjun; Rosano, Jenna M.; Wang, Yi; Garson, Charles J.; Prabhakarpandian, Balabhaskar; Pant, Kapil] CFD Res Corp, Huntsville, AL 35806 USA.
[Klarmann, George J.; Perantoni, Alan; Alvarez, Luis M.] NCI, Canc & Dev Biol Lab, Frederick, MD 21702 USA.
[Alvarez, Luis M.] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA.
[Lai, Eva] Johns Hopkins Univ, Dept Chem & Biomol Engn, Baltimore, MD 21218 USA.
[Lai, Eva] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA.
RP Wang, Y (reprint author), CFD Res Corp, 701 McMillian Way NW, Huntsville, AL 35806 USA.
EM yxw@cfdrc.com
FU U.S. Army Medical Research and Materiel Command (USAMRMC) under SBIR
contract [W81XWH-12-C-0069]
FX This research was sponsored by the U.S. Army Medical Research and
Materiel Command (USAMRMC) under SBIR contract no. W81XWH-12-C-0069. GJK
and LMA acknowledge Dr. Alan Perantoni and Ms. Nirmala Sharma of the
Cancer and Developmental Biology Laboratory for providing access to
specialized tissue culture facilities and for discussions regarding
analysis of differentiation and development markers.
NR 50
TC 22
Z9 23
U1 9
U2 60
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 1473-0197
EI 1473-0189
J9 LAB CHIP
JI Lab Chip
PY 2015
VL 15
IS 5
BP 1320
EP 1328
DI 10.1039/c4lc01253d
PG 9
WC Biochemical Research Methods; Chemistry, Multidisciplinary; Nanoscience
& Nanotechnology
SC Biochemistry & Molecular Biology; Chemistry; Science & Technology -
Other Topics
GA CB7WC
UT WOS:000349838200012
PM 25589423
ER
PT J
AU Killops, KL
Rodriguez, CG
Lundberg, P
Hawker, CJ
Lynd, NA
AF Killops, Kato L.
Rodriguez, Christina G.
Lundberg, Pontus
Hawker, Craig J.
Lynd, Nathaniel A.
TI A synthetic strategy for the preparation of sub-100 nm functional
polymer particles of uniform diameter
SO POLYMER CHEMISTRY
LA English
DT Article
ID BLOCK-COPOLYMERS; EMULSION POLYMERIZATION; DISPERSION POLYMERIZATION;
HAIRY PARTICLES; NANOPARTICLES; SURFACTANTS; STABILIZERS; TECHNOLOGY;
STYRENE; LATEX
AB An amphiphilic block copolymer surfactant is used to impart peripheral surface functionality to polymer nanoparticles synthesized via emulsion polymerization. Particles ranged in size from ca. 55 nm by SEM (ca. 82 nm by DLS) to just over 200 nm. Particles displaying latent functionality were readily functionalized directly after polymerization using a fluorescent dye.
C1 [Killops, Kato L.] US Army, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA.
[Rodriguez, Christina G.; Lynd, Nathaniel A.] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Joint Ctr Artificial Photosynthesis, Berkeley, CA 94720 USA.
[Rodriguez, Christina G.; Hawker, Craig J.; Lynd, Nathaniel A.] Univ Calif Santa Barbara, Mat Res Lab, Santa Barbara, CA 93106 USA.
[Lundberg, Pontus] Thermo Fisher Sci, Life Sci Solut, N-2001 Lillestrom, Norway.
[Lynd, Nathaniel A.] Univ Texas Austin, McKetta Dept Chem Engn, Austin, TX 78712 USA.
RP Killops, KL (reprint author), US Army, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA.
EM kathryn.l.killops.civ@mail.mil; lynd@che.utexas.edu
FU Department of the Army Basic Research Program; Edgewood Chemical
Biological Center; Army Research Office through the Institute for
Collaborative Biotechnologies at University of California, Santa Barbara
[W911NF-09-D-0001-0028]; MRSEC Program of the National Science
Foundation [DMR 1121053]
FX This research is funded by the Department of the Army Basic Research
Program and sponsored by the Edgewood Chemical Biological Center.
Funding for C.R. was provided by the Army Research Office through the
Institute for Collaborative Biotechnologies at University of California,
Santa Barbara under award number W911NF-09-D-0001-0028. This work was
partially supported by the MRSEC Program of the National Science
Foundation under Award no. DMR 1121053.
NR 37
TC 5
Z9 5
U1 1
U2 28
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 1759-9954
EI 1759-9962
J9 POLYM CHEM-UK
JI Polym. Chem.
PY 2015
VL 6
IS 9
BP 1431
EP 1435
DI 10.1039/c4py01703j
PG 5
WC Polymer Science
SC Polymer Science
GA CB7UB
UT WOS:000349832300002
ER
PT J
AU Thompson, CM
Seiter, J
Chappell, MA
Tappero, RV
Proctor, DM
Suh, M
Wolf, JC
Haws, LC
Vitale, R
Mittal, L
Kirman, CR
Hays, SM
Harris, MA
AF Thompson, Chad M.
Seiter, Jennifer
Chappell, Mark A.
Tappero, Ryan V.
Proctor, Deborah M.
Suh, Mina
Wolf, Jeffrey C.
Haws, Laurie C.
Vitale, Rock
Mittal, Liz
Kirman, Christopher R.
Hays, Sean M.
Harris, Mark A.
TI Synchrotron-Based Imaging of Chromium and gamma-H2AX Immunostaining in
the Duodenum Following Repeated Exposure to Cr(VI) in Drinking Water
SO TOXICOLOGICAL SCIENCES
LA English
DT Article
DE hexavalent chromium; Cr(VI); synchrotron; duodenum; carcinogenesis; mode
of action; H2AX
ID HEXAVALENT CHROMIUM; STEM-CELLS; B6C3F1 MICE; PHARMACOKINETIC MODEL;
CANCER; HUMANS; RATS; CARCINOGENESIS; RELEVANCE; TOXICITY
AB Current drinking water standards for chromium are for the combined total of both hexavalent and trivalent chromium (Cr(VI) and Cr(III)). However, recent studies have shown that Cr(III) is not carcinogenic to rodents, whereas mice chronically exposed to high levels of Cr(VI) developed duodenal tumors. These findings may suggest the need for environmental standards specific for Cr(VI). Whether the intestinal tumors arose through a mutagenic or non-mutagenic mode of action (MOA) greatly impacts how drinking water standards for Cr(VI) are derived. Herein, X-ray fluorescence (spectro)microscopy (A mu-XRF) was used to image the Cr content in the villus and crypt regions of duodena from B6C3F1 mice exposed to 180 mg/l Cr(VI) in drinking water for 13 weeks. DNA damage was also assessed by gamma-H2AX immunostaining. Exposure to Cr(VI) induced villus blunting and crypt hyperplasia in the duodenum-the latter evidenced by lengthening of the crypt compartment by similar to 2-fold with a concomitant 1.5-fold increase in the number of crypt enterocytes. gamma-H2AX immunostaining was elevated in villi, but not in the crypt compartment. A mu-XRF maps revealed mean Cr levels > 30 times higher in duodenal villi than crypt regions; mean Cr levels in crypt regions were only slightly above background signal. Despite the presence of Cr and elevated gamma-H2AX immunoreactivity in villi, no aberrant foci indicative of transformation were evident. These findings do not support a MOA for intestinal carcinogenesis involving direct Cr-DNA interaction in intestinal stem cells, but rather support a non-mutagenic MOA involving chronic wounding of intestinal villi and crypt cell hyperplasia.
C1 [Thompson, Chad M.; Mittal, Liz; Harris, Mark A.] ToxStrategies Inc, Katy, TX 77494 USA.
[Seiter, Jennifer; Chappell, Mark A.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Tappero, Ryan V.] Brookhaven Natl Lab, Photon Sci Dept, Upton, NY 11973 USA.
[Proctor, Deborah M.; Suh, Mina] ToxStrategies Inc, Mission Viejo, CA 92692 USA.
[Wolf, Jeffrey C.] Expt Pathol Labs, Sterling, VA 20166 USA.
[Haws, Laurie C.] ToxStrategies Inc, Austin, TX 78731 USA.
[Vitale, Rock] Environm Stand Inc, Valley Forge, PA 19482 USA.
[Kirman, Christopher R.] Summit Toxicol LLP, Orange Village, OH 44022 USA.
[Hays, Sean M.] Summit Toxicol LLP, Allenspark, CO 80510 USA.
RP Thompson, CM (reprint author), ToxStrategies Inc, 23123 Cinco Ranch Blvd,Suite 220, Katy, TX 77494 USA.
EM cthompson@toxstrategies.com
FU Cr(VI) Panel of the American Chemistry Council; DOE, Office of Science,
Office of Basic Energy Sciences [DE-AC02-98CH10886]
FX This work was supported by the Cr(VI) Panel of the American Chemistry
Council.; Use of the NSLS (National Synchrotron Light Source) was
supported by the DOE, Office of Science, Office of Basic Energy
Sciences, under Contract No. DE-AC02-98CH10886.
NR 48
TC 9
Z9 9
U1 1
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
EI 1096-0929
J9 TOXICOL SCI
JI Toxicol. Sci.
PD JAN
PY 2015
VL 143
IS 1
BP 16
EP 25
DI 10.1093/toxsci/kfu206
PG 10
WC Toxicology
SC Toxicology
GA CC1LH
UT WOS:000350101700004
PM 25352572
ER
PT J
AU Veress, LA
Anderson, DR
Hendry-Hofer, TB
Houin, PR
Rioux, JS
Garlick, RB
Loader, JE
Paradiso, DC
Smith, RW
Rancourt, RC
Holmes, WW
White, CW
AF Veress, Livia A.
Anderson, Dana R.
Hendry-Hofer, Tara B.
Houin, Paul R.
Rioux, Jacqueline S.
Garlick, Rhonda B.
Loader, Joan E.
Paradiso, Danielle C.
Smith, Russell W.
Rancourt, Raymond C.
Holmes, Wesley W.
White, Carl W.
TI Airway Tissue Plasminogen Activator Prevents Acute Mortality Due to
Lethal Sulfur Mustard Inhalation
SO TOXICOLOGICAL SCIENCES
LA English
DT Article
DE tPA; airway fibrin; sulfur mustard; fibrinolysis; plastic bronchitis
ID ACUTE LUNG INJURY; ANALOG INHALATION; OBSTRUCTION; PERSPECTIVE;
COAGULATION
AB Rationale: Sulfur mustard (SM) is a chemical weapon stockpiled today in volatile regions of the world. SM inhalation causes a life-threatening airway injury characterized by airway obstruction from fibrin casts, which can lead to respiratory failure and death. Mortality in those requiring intubation is more than 80%. No therapy exists to prevent mortality after SM exposure. Our previous work using the less toxic analog of SM, 2-chloroethyl ethyl sulfide, identified tissue plasminogen activator (tPA) an effective rescue therapy for airway cast obstruction (Veress, L. A., Hendry-Hofer, T. B., Loader, J. E., Rioux, J. S., Garlick, R. B., and White, C. W. (2013). Tissue plasminogen activator prevents mortality from sulfur mustard analog-induced airway obstruction. Am. J. Respir. Cell Mol. Biol. 48, 439-447). It is not known if exposure to neat SM vapor, the primary agent used in chemical warfare, will also cause death due to airway casts, and if tPA could be used to improve outcome. Methods: Adult rats were exposed to SM, and when oxygen saturation reached less than 85% (median: 6.5 h), intratracheal tPA or placebo was given under isoflurane anesthesia every 4 h for 48 h. Oxygen saturation, clinical distress, and arterial blood gases were assessed. Microdissection was done to assess airway obstruction by casts. Results: Intratracheal tPA treatment eliminated mortality (0% at 48 h) and greatly improved morbidity after lethal SM inhalation (100% death in controls). tPA normalized SM-associated hypoxemia, hypercarbia, and lactic acidosis, and improved respiratory distress. Moreover, tPA treatment resulted in greatly diminished airway casts, preventing respiratory failure from airway obstruction. Conclusions: tPA given via airway more than 6 h after exposure prevented death from lethal SM inhalation, and normalized oxygenation and ventilation defects, thereby rescuing from respiratory distress and failure. Intra-airway tPA should be considered as a life-saving rescue therapy after a significant SM inhalation exposure incident.
C1 [Veress, Livia A.; Hendry-Hofer, Tara B.; Houin, Paul R.; Rioux, Jacqueline S.; Garlick, Rhonda B.; Loader, Joan E.; Smith, Russell W.; Rancourt, Raymond C.; White, Carl W.] Univ Colorado Denver, Dept Pediat, Aurora, CO 80045 USA.
[Anderson, Dana R.; Paradiso, Danielle C.; Holmes, Wesley W.] US Army, Med Toxicol Branch, Analyt Toxicol Div, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA.
RP Veress, LA (reprint author), Univ Colorado Denver, Pediat Airway Res Ctr, Dept Pediat Pulmonol, Mailstop 8615,12700 E 19th Ave, Aurora, CO 80045 USA.
EM Livia.Veress@ucdenver.edu
FU CounterACT Program, National Institutes of Health (NIH), Office of the
Director; National Institute of Environmental Health Sciences (NIEHS)
[U54 ES015678]
FX This research is supported by the CounterACT Program, National
Institutes of Health (NIH), Office of the Director, and the National
Institute of Environmental Health Sciences (NIEHS), Grant Number U54
ES015678 (CWW).
NR 23
TC 6
Z9 6
U1 0
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
EI 1096-0929
J9 TOXICOL SCI
JI Toxicol. Sci.
PD JAN
PY 2015
VL 143
IS 1
BP 178
EP 184
DI 10.1093/toxsci/kfu225
PG 7
WC Toxicology
SC Toxicology
GA CC1LH
UT WOS:000350101700019
PM 25331496
ER
PT J
AU Berger, ST
Netherland, MD
MacDonald, GE
AF Berger, Sarah T.
Netherland, Michael D.
MacDonald, Gregory E.
TI Laboratory Documentation of Multiple-Herbicide Tolerance to Fluridone,
Norflurazon, and Topramazone in a Hybrid Watermilfoil (Myriophyllum
spicatum x M. sibiricum) Population
SO WEED SCIENCE
LA English
DT Article
DE Aquatic weeds; herbicide resistance; herbicide tolerance
ID HYDRILLA HYDRILLA-VERTICILLATA; EURASIAN WATERMILFOIL; RESISTANT
HYDRILLA; PLANT COMMUNITY; TRICLOPYR; PHYTOENE; MILFOIL; LAKE;
INHIBITORS; EVOLUTION
AB Invasive watermilfoils, specifically Eurasian watermilfoil and the interspecific hybrid of Eurasian watermilfoil x northern watermilfoil, continue to be problematic for water resource managers. Herbicides are often used to control these nuisance weeds and have been historically successful in controlling Eurasian watermilfoil. A population of hybrid watermilfoil from Townline Lake in Michigan has shown increased tolerance to the herbicide fluridone. The objective of this work is to determine if cross-and multiple tolerance have also developed in this population. Eurasian watermilfoil plants collected from multiple sites and plants from Townline Lake were treated with 0, 5, 10, 20, 40, or 80 mu g L-1 of fluridone, norflurazon, or topramezone. Fluridone and norflurazon inhibit phytoene desaturase, whereas topramezone is a 4-hydroxyphenylpyruvate dioxygenase-inhibiting herbicide. Chlorophyll fluorescence (F-v/F-m) and pigment content was measured at 10 d after treatment. Townline Lake plants responded differently from susceptible plants when treated with fluridone, norflurazon, and topramezone at 40 mu g L-1. These results indicate that the Townline population of hybrid watermilfoil has inherent tolerance to multiple herbicide modes of action. These results are especially significant as topramezone has recently been labeled for aquatic use. Screening of additional herbicides to determine potential herbicide tolerance of the Townline Lake population is recommended.
Nomenclature: Fluridone; norflurazon; topramezone; Eurasian watermilfoil, Myriophyllum spicatum L.; hybrid watermilfoil, M. spicatum x M. sibiricum; northern watermilfoil, M. sibiricum Komarov.
C1 [Berger, Sarah T.; MacDonald, Gregory E.] Univ Florida, Dept Agron, Gainesville, FL 32611 USA.
[Netherland, Michael D.] US Army, Gainesville, FL 32653 USA.
RP Netherland, MD (reprint author), US Army, Gainesville, FL 32653 USA.
EM mdnether@ufl.edu
NR 28
TC 5
Z9 5
U1 5
U2 21
PU WEED SCI SOC AMER
PI LAWRENCE
PA 810 EAST 10TH ST, LAWRENCE, KS 66044-8897 USA
SN 0043-1745
EI 1550-2759
J9 WEED SCI
JI Weed Sci.
PD JAN-MAR
PY 2015
VL 63
IS 1
BP 235
EP 241
DI 10.1614/WS-D-14-00085.1
PG 7
WC Agronomy; Plant Sciences
SC Agriculture; Plant Sciences
GA CB7BW
UT WOS:000349782100003
ER
PT J
AU Karthik, VU
Sivasuthan, S
Rahunanthan, A
Thyagarajan, RS
Jayakumar, P
Udpa, L
Hoole, SRH
AF Karthik, Victor U.
Sivasuthan, Sivamayam
Rahunanthan, Arunasalam
Thyagarajan, Ravi S.
Jayakumar, Paramsothy
Udpa, Lalita
Hoole, S. Ratnajeevan H.
TI Faster, more accurate, parallelized inversion for shape optimization in
electroheat problems on a graphics processing unit (GPU) with the
real-coded genetic algorithm
SO COMPEL-THE INTERNATIONAL JOURNAL FOR COMPUTATION AND MATHEMATICS IN
ELECTRICAL AND ELECTRONIC ENGINEERING
LA English
DT Article
DE CAD; Finite element methods; Applied electromagnetics; Computational
methods; Genetic algorithms; Field optimization
ID OPTIMAL-DESIGN; FINITE-ELEMENTS; HYPERTHERMIA; COMPUTATION; DEVICES; 3-D
AB Purpose - Inverting electroheat problems involves synthesizing the electromagnetic arrangement of coils and geometries to realize a desired heat distribution. To this end two finite element problems need to be solved, first for the magnetic fields and the joule heat that the associated eddy currents generate and then, based on these heat sources, the second problem for heat distribution. This two-part problem needs to be iterated on to obtain the desired thermal distribution by optimization. Being a time consuming process, the purpose of this paper is to parallelize the process using the graphics processing unit (GPU) and the real-coded genetic algorithm, each for both speed and accuracy.
Design/methodology/approach - This coupled problem represents a heavy computational load with long wait-times for results. The GPU has recently been demonstrated to enhance the efficiency and accuracy of the finite element computations and cut down solution times. It has also been used to speedup the naturally parallel genetic algorithm. The authors use the GPU to perform coupled electroheat finite element optimization by the genetic algorithm to achieve computational efficiencies far better than those reported for a single finite element problem. In the genetic algorithm, coding objective functions in real numbers rather than binary arithmetic gives added speed and accuracy.
Findings - The feasibility of the method proposed to reduce computational time and increase accuracy is established through the simple problem of shaping a current carrying conductor so as to yield a constant temperature along a line. The authors obtained a speedup (CPU time to GPU time ratio) saturating to about 28 at a population size of 500 because of increasing communications between threads. But this far better than what is possible on a workstation.
Research limitations/implications - By using the intrinsically parallel genetic algorithm on a GPU, large complex coupled problems may be solved very quickly. The method demonstrated here without accounting for radiation and convection, may be trivially extended to more completely modeled electroheat systems. Since the primary purpose here is to establish methodology and feasibility, the thermal problem is simplified by neglecting convection and radiation. While that introduces some error, the computational procedure is still validated.
Practical implications - The methodology established has direct applications in electrical machine design, metallurgical mixing processes, and hyperthermia treatment in oncology. In these three practical application areas, the authors need to compute the exciting coil (or antenna) arrangement (current magnitude and phase) and device geometry that would accomplish a desired heat distribution to achieve mixing, reduce machine heat or burn cancerous tissue. This process presented does it more accurately and speedily.
Social implications - Particularly the above-mentioned application in oncology will alleviate human suffering through use in hyperthermia treatment planning in cancer treatment. The method presented provides scope for new commercial software development and employment.
Originality/value - Previous finite element shape optimization of coupled electroheat problems by this group used gradient methods whose difficulties are explained. Others have used analytical and circuit models in place of finite elements. This paper applies the massive parallelization possible with GPUs to the inherently parallel genetic algorithm, and extends it from single field system problems to coupled problems, and thereby realizes practicable solution times for such a computationally complex problem. Further, by using GPU computations rather than CPU, accuracy is enhanced. And then by using real number rather than binary coding for object functions, further accuracy and speed gains are realized.
C1 [Karthik, Victor U.; Sivasuthan, Sivamayam; Udpa, Lalita; Hoole, S. Ratnajeevan H.] Michigan State Univ, Dept Elect & Comp Engn, E Lansing, MI 48824 USA.
[Rahunanthan, Arunasalam] Edinboro Univ, Dept Math & Comp Sci, Edinboro, PA USA.
[Thyagarajan, Ravi S.; Jayakumar, Paramsothy] US Army Tank Automot Res Dev & Engn Ctr, Warren, MI USA.
RP Hoole, SRH (reprint author), Michigan State Univ, Dept Elect & Comp Engn, E Lansing, MI 48824 USA.
EM hoole@egr.msu.edu
NR 39
TC 1
Z9 1
U1 2
U2 7
PU EMERALD GROUP PUBLISHING LIMITED
PI BINGLEY
PA HOWARD HOUSE, WAGON LANE, BINGLEY BD16 1WA, W YORKSHIRE, ENGLAND
SN 0332-1649
J9 COMPEL
JI Compel-Int. J. Comp. Math. Electr. Electron. Eng.
PY 2015
VL 34
IS 1
BP 344
EP 356
DI 10.1108/COMPEL-06-2014-0146
PG 13
WC Computer Science, Interdisciplinary Applications; Engineering,
Electrical & Electronic; Mathematics, Applied
SC Computer Science; Engineering; Mathematics
GA CB5BE
UT WOS:000349641700021
ER
PT J
AU Field, AE
Jones, CL
Kelly, R
Marko, ST
Kern, SJ
Ricol, PJ
AF Field, Amy E.
Jones, Cynthia L.
Kelly, Richard, III
Marko, Shannon T.
Kern, Steven J.
Ricol, Pedro J.
TI Measurement of Fecal Corticosterone Metabolites as a Predictor of the
Habituation of Rhesus Macaques (Macaca mulatta) to Jacketing
SO JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE
LA English
DT Article
ID SELF-INJURIOUS-BEHAVIOR; CHIMPANZEES PAN-TROGLODYTES; URINARY CORTISOL
RESPONSES; NONHUMAN-PRIMATES; PERSONALITY DIMENSIONS; LONGTAILED
MACAQUES; IMMUNE FUNCTION; ROOM CHANGE; STRESS; MONKEYS
AB Jacket use in NHP is a common practice and is often considered a form of refinement during experiments necessitating extended periods of catheterization. An important consideration when using jackets is the physiologic effects that jacketing has on NHP and its potential to confound research. Several studies have evaluated the stress response and habituation of NHP to various forms of restraint, but none have looked directly at the timeframe necessary for the habituation of rhesus macaques (Macaca mulatta) to jackets. We set out to determine whether 3 d was a sufficient timeframe for this species to become habituated to a jacket, with or without an undershirt, by evaluating 2 major physiologic parameters. After jacket placement, we measured food consumption and collected fecal samples to measure fecal corticosterone metabolites (FCM) daily for 2 wk. FCM measurements for NHP without undershirts were significantly increased for days 2 and 3 after jacketing before returning to baseline levels. FCM measurements for NHP with undershirts were significantly increased for only 1 d after jacketing, suggesting that the undershirt has a, positive effect on jacket habituation. There were no measurable differences in food consumption during the jacket habituation period. Furthermore, no significant differences were noted between sexes. These findings suggest that FCM levels return to baseline 3 d after jacketing and could be a useful predictor of jacket habituation in rhesus macaques.
C1 [Field, Amy E.; Jones, Cynthia L.; Kelly, Richard, III; Marko, Shannon T.; Ricol, Pedro J.] US Army, Med Res Inst Infect Dis, Vet Med Div, Ft Detrick, MD 21702 USA.
[Kern, Steven J.] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
RP Field, AE (reprint author), US Army, Med Res Inst Infect Dis, Vet Med Div, Ft Detrick, MD 21702 USA.
EM amy.e.field.mil@mail.mil
FU Vet Med Division under USAMRIID [150874]
FX Opinions, interpretations, conclusions, and recommendations are those of
the authors and are not necessarily endorsed by the US Army or the
Department of Defense. We thank MAJ Krystal Bean, LTC Carrie Benton, and
Dr Emily Bailey for their editorial review. We thank Dr Janine Brown
from the Smithsonian Conservation Biology Institute for analyzing the
fecal corticosterone metabolite samples. In addition we thank the
USAMRIID Veterinary Medicine NHP and Behavior Management Sections for
study support. This research was funded by the Vet Med Division under
USAMRIID project number 150874.
NR 42
TC 1
Z9 1
U1 1
U2 6
PU AMER ASSOC LABORATORY ANIMAL SCIENCE
PI MEMPHIS
PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA
SN 1559-6109
J9 J AM ASSOC LAB ANIM
JI J. Amer. Assoc. Lab. Anim. Sci.
PD JAN
PY 2015
VL 54
IS 1
BP 59
EP 65
PG 7
WC Veterinary Sciences; Zoology
SC Veterinary Sciences; Zoology
GA CB4DF
UT WOS:000349577700010
PM 25651092
ER
PT J
AU Woodring, JL
Patel, G
Erath, J
Behera, R
Lee, PJ
Leed, SE
Rodriguez, A
Sciotti, RJ
Mensa-Wilmot, K
Pollastri, MP
AF Woodring, Jennifer L.
Patel, Gautam
Erath, Jessey
Behera, Ranjan
Lee, Patricia J.
Leed, Susan E.
Rodriguez, Ana
Sciotti, Richard J.
Mensa-Wilmot, Kojo
Pollastri, Michael P.
TI Evaluation of aromatic 6-substituted thienopyrimidines as scaffolds
against parasites that cause trypanosomiasis, leishmaniasis, and malaria
SO MEDCHEMCOMM
LA English
DT Article
ID TYROSINE KINASE INHIBITOR; AFRICAN SLEEPING SICKNESS; DRUG DISCOVERY;
LEAD COMPOUND; CANCER; LAPATINIB; TARGETS; SCREEN; GROWTH
AB Target repurposing is a proven method for finding new lead compounds that target Trypanosoma brucei, the causative agent of human African trypanosomiasis. Due to the recent discovery of a lapatinib-derived analog 2 with excellent potency against T. brucei (EC50 = 42 nM) and selectivity over human host cells, we have explored other classes of human tyrosine kinase inhibitor scaffolds in order to expand the range of chemotypes for pursuit. Following library expansion, we found compound 11e to have an EC50 of 84 nM against T. brucei cells while maintaining selectivity over human hepatocytes. In addition, the library was tested against causative agents of Chagas' disease, leishmaniasis, and malaria. Two analogs with sub-micromolar potencies for T. cruzi (4j) and Plasmodium falciparum (11j) were discovered, along with an analog with considerable potency against Leishmania major amastigotes (4e). Besides identifying new and potent protozoan growth inhibitors, these data highlight the value of concurrent screening of a chemical library against different protozoan parasites.
C1 [Woodring, Jennifer L.; Patel, Gautam; Pollastri, Michael P.] Northeastern Univ, Dept Chem & Chem Biol, Boston, MA 02115 USA.
[Erath, Jessey; Rodriguez, Ana] NYU, Sch Med, Dept Microbiol, Div Parasitol, New York, NY 10010 USA.
[Behera, Ranjan; Mensa-Wilmot, Kojo] Univ Georgia, Dept Cellular Biol, Athens, GA 30602 USA.
[Lee, Patricia J.; Leed, Susan E.; Sciotti, Richard J.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
[Rodriguez, Ana] NYU, Sch Med, Antiinfect Screening Core, New York, NY 10010 USA.
RP Pollastri, MP (reprint author), Northeastern Univ, Dept Chem & Chem Biol, 360 Huntington Ave, Boston, MA 02115 USA.
EM m.pollastri@neu.edu
OI Rodriguez, Ana/0000-0002-0060-3405
FU NIH [R01AI082577, R56AI099476, R21AI076647]
FX This work was funded in part by NIH grants R01AI082577 (MPP),
R56AI099476 (MPP and KM-W), and R21AI076647 (KM-W). We thank
GlaxoSmithKline for providing GW837016X that was used in exploratory
studies with T. brucei. We appreciate a free academic license for the
OpenEye suite of software, and are grateful to AstraZeneca for
performing the in vitro ADME experiments described in this manuscript.
NR 24
TC 5
Z9 5
U1 0
U2 6
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 2040-2503
EI 2040-2511
J9 MEDCHEMCOMM
JI MedChemComm
PY 2015
VL 6
IS 2
BP 339
EP 346
DI 10.1039/c4md00441h
PG 8
WC Biochemistry & Molecular Biology; Chemistry, Medicinal
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA CB5WV
UT WOS:000349699600011
PM 25685309
ER
PT J
AU Deng-Bryant, Y
Readnower, RD
Leung, LY
Cunningham, TL
Shear, DA
Tortella, FC
AF Deng-Bryant, Ying
Readnower, Ryan D.
Leung, Lai Yee
Cunningham, Tracy L.
Shear, Deborah A.
Tortella, Frank C.
TI Treatment with amnion-derived cellular cytokine solution (ACCS) induces
persistent motor improvement and ameliorates neuroinflammation in a rat
model of penetrating ballistic-like brain injury
SO RESTORATIVE NEUROLOGY AND NEUROSCIENCE
LA English
DT Article
DE Amnion-derived cellular cytokine solution; penetrating ballistic-like
brain injury; rotarod; morris water maze; neuroinflammation; microglia;
neutrophil; neurodegeneration
ID WHITE-MATTER INJURY; CLOSED-HEAD INJURY; BARRIER PERMEABILITY;
GROWTH-FACTOR; NEONATAL-RAT; FUNCTIONAL RECOVERY; MICROGLIAL CELLS;
IMMUNE-RESPONSE; EDEMA FORMATION; SMALL MOLECULES
AB Purpose: The present work compared the behavioral outcomes of ACCS therapy delivered either intravenously (i.v.) or intracerebroventricularly (i.c.v.) after penetrating ballistic-like brain injury (PBBI). Histological markers for neuroinflammation and neurodegeneration were employed to investigate the potential therapeutic mechanism of ACCS.
Methods: Experiment-1, ACCS was administered either i.v. or i.c.v. for 1 week post-PBBI. Outcome metrics included behavioral (rotarod and Morris water maze) and gross morphological assessments. Experiment-2, rats received ACCS i.c.v for either 1 or 2 weeks post-PBBI. The inflammatory response was determined by immunohistochemistry for neutrophils and microglia reactivity. Neurodegeneration was visualized using silver staining.
Results: Both i.v. and i.c.v. delivery of ACCS improved motor outcome but failed to improve cognitive outcome or tissue sparing. Importantly, only i.c.v. ACCS treatment produced persistent motor improvements at a later endpoint. The i.c.v. ACCS treatment significantly reduced PBBI-induced increase in myeloperoxidase (MPO) and ionized calcium binding adaptor molecule 1 (Iba1) expression. Concomitant reduction of both Iba1 and silver staining were detected in corpus callosum with i.c.v. ACCS treatment.
Conclusions: ACCS, as a treatment for TBI, showed promise with regard to functional (motor) recovery and demonstrated strong capability to modulate neuroinflammatory responses that may underline functional recovery. However, the majority of beneficial effects appear restricted to the i.c.v. route of ACCS delivery, which warrants future studies examining delivery routes (e.g. intranasal delivery) which are more clinically viable for the treatment of TBI.
C1 [Deng-Bryant, Ying; Readnower, Ryan D.; Leung, Lai Yee; Cunningham, Tracy L.; Shear, Deborah A.; Tortella, Frank C.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect & Neurorestorat Branch, Silver Spring, MD 20910 USA.
RP Deng-Bryant, Y (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect & Neurorestorat Branch, 503 Robert Grant Ave Room 2W12, Silver Spring, MD 20910 USA.
EM ying.d.bryant.civ@mail.mil
FU CDMRP [W81XWH-08-2-0127]
FX The authors are grateful for the excellent technical assistance provided
by Christopher van der Merwe and Francis P. Bustos. This work was funded
by CDMRP W81XWH-08-2-0127.
NR 53
TC 1
Z9 1
U1 0
U2 2
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 0922-6028
EI 1878-3627
J9 RESTOR NEUROL NEUROS
JI Restor. Neurol. Neurosci.
PY 2015
VL 33
IS 2
BP 189
EP 203
DI 10.3233/RNN-140455
PG 15
WC Neurosciences
SC Neurosciences & Neurology
GA CB7UX
UT WOS:000349835000009
PM 25588460
ER
PT J
AU Akers, KS
Rowan, MP
Niece, KL
Stewart, IJ
Mende, K
Cota, JM
Murray, CK
Chung, KK
AF Akers, Kevin S.
Rowan, Matthew P.
Niece, Krista L.
Stewart, Ian J.
Mende, Katrin
Cota, Jason M.
Murray, Clinton K.
Chung, Kevin K.
TI Colistin Pharmacokinetics in Burn Patients during Continuous Venovenous
Hemofiltration
SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
LA English
DT Article
ID PERFORMANCE LIQUID-CHROMATOGRAPHY; RENAL REPLACEMENT THERAPY;
CRITICALLY-ILL PATIENTS; HIGH-VOLUME HEMOFILTRATION; FIELD
GEL-ELECTROPHORESIS; ACUTE KIDNEY INJURY; ACINETOBACTER-BAUMANNII;
POPULATION PHARMACOKINETICS; PSEUDOMONAS-AERUGINOSA; PROTEIN-BINDING
AB While colistin is considered a last resort for the treatment of multidrug-resistant Gram-negative bacterial infections, there has been an increase in its use due to the increasing prevalence of drug-resistant infections worldwide. The pharmacology of colistin is complex, and pharmacokinetic data are limited, especially in patients requiring renal replacement therapy. As a result, dosing for patients who require renal replacement remains a challenge. Here, we present pharmacokinetic data for colistin from two burn patients (37 and 68 years old) infected with colistin-susceptible isoclonal Acinetobacter baumannii and receiving continuous venovenous hemofiltration (CVVH). To our knowledge, we are the first to examine data from before and during CVVH (for one patient), allowing analysis of the effect of CVVH on colistin pharmacokinetics. Pharmacokinetic/pharmacodynamic analysis indicated that a dose increase from 1.5 to 2.2 mg/kg of body weight colistin base activity on CVVH was insufficient to satisfy the target parameter of an AUC24/MIC (area under the concentration- time curve over 24 h in the steady state divided by the MIC) of >= 60 at an MIC of >= 1 mu g/ml in one patient with residual endogenous renal function. Plasma concentrations of colistin ranged from 0 to 15 mu g/ml, with free colistin levels ranging from 0.4 to 2.2 mu g/ml. While both patients resolved their clinical infections and survived to discharge, colistin-resistant colonizing isolates resulted from therapy in one patient. The variabilities observed in colistin concentrations and pharmacokinetic characteristics highlight the importance of pharmacokinetic monitoring of antibiotics in patients undergoing renal replacement therapy.
C1 [Akers, Kevin S.; Rowan, Matthew P.; Niece, Krista L.; Chung, Kevin K.] United States Army, Inst Surg Res, Ft Sam Houston, San Antonio, TX USA.
[Akers, Kevin S.; Stewart, Ian J.; Mende, Katrin; Murray, Clinton K.] Brooke Army Med Ctr, Ft Sam Houston, San Antonio, TX USA.
[Mende, Katrin] Infect Dis Clin Res Program, Bethesda, MD USA.
[Cota, Jason M.] Univ Incarnate Word, Feik Sch Pharm, San Antonio, TX USA.
[Chung, Kevin K.] Uniformed Serv Univ Hlth Sci, Hlth Sci, Bethesda, MD USA.
RP Akers, KS (reprint author), United States Army, Inst Surg Res, Ft Sam Houston, San Antonio, TX USA.
EM kevin.s.akers.mil@mail.mil
FU Defense Medical Research & Development Program (DMRDP) Military
Infectious Disease Clinical Trial Award (MID-CTA)
[D_MIDCTA_I_12_J2_299]; U.S. Department of Energy; USAMRMC
FX This work was supported by Defense Medical Research & Development
Program (DMRDP) Military Infectious Disease Clinical Trial Award
(MID-CTA) D_MIDCTA_I_12_J2_299 and, in part, by an appointment to the
Postgraduate Research Participation Program at the U.S. Army Institute
of Surgical Research administered by the Oak Ridge Institute for Science
and Education through an interagency agreement between the U.S.
Department of Energy and USAMRMC.
NR 45
TC 9
Z9 9
U1 0
U2 3
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0066-4804
EI 1098-6596
J9 ANTIMICROB AGENTS CH
JI Antimicrob. Agents Chemother.
PD JAN
PY 2015
VL 59
IS 1
BP 46
EP 52
DI 10.1128/AAC.03783-14
PG 7
WC Microbiology; Pharmacology & Pharmacy
SC Microbiology; Pharmacology & Pharmacy
GA CA0LO
UT WOS:000348609500005
PM 25313211
ER
PT J
AU Taylor, S
Park, E
Bullion, K
Dontsova, K
AF Taylor, Susan
Park, Eileen
Bullion, Katherine
Dontsova, Katerina
TI Dissolution of three insensitive munitions formulations
SO CHEMOSPHERE
LA English
DT Article
DE Insensitive munitions; DNAN; NTO; Dissolution; Micro-computed tomography
ID DETONATION; NTO; PERCHLORATE; RESIDUES; RDX; HMX
AB The US military fires live munitions during training. To save soldiers lives both during training and war, the military is developing insensitive munitions (IM) that minimize unintentional detonations. Some of the compounds in the IM formulation are, however, very soluble in water, raising environmental concerns about their fate and transport. We measured the dissolution of three of these IM formulations, IMX101, IMX104 and PAX21 using laboratory drip tests and studied the accompanying changes in particle structure using micro computed tomography. Our laboratory drip tests mimic conditions on training ranges, where spatially isolated particles of explosives scattered by partial detonations are dissolved by rainfall.
We found that the constituents of these IM formulations dissolve sequentially and in the order predicted by their aqueous solubility. The order of magnitude differences in solubility among their constituents produce water solutions whose compositions and concentrations vary with time. For IMX101 and IMX104, that contain 3-nitro-1,2,4-triazol-5-one (NTO), the solutions also vary in pH. The good mass balances measured for the drip tests indicate that the formulations are not being photo-or bio-transformed under laboratory conditions. Published by Elsevier Ltd.
C1 [Taylor, Susan; Park, Eileen; Bullion, Katherine] Cold Reg Res & Engn Lab, Hanover, NH 03755 USA.
[Dontsova, Katerina] Univ Arizona, Tucson, AZ 85721 USA.
RP Taylor, S (reprint author), Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA.
EM Susan.Taylor@erdc.dren.mil
FU Women in Science Program; Strategic Environmental Research and
Development Program [SERDP ER- 2220, ER-2219]
FX At Dartmouth College, we thank Drs. Mark McPeek and Charles Daghlian for
training on and use of the mu CT scanner and the Women in Science
Program for supporting two of the authors, KB and EP. We thank Anthony
Di Stasio of Picatinny Arsenal for providing undetonated IM pieces and
my colleagues Michael and Marianne Walsh for their help in the field and
in the laboratory. Lastly, we thank Dr. Andrea Leeson of the Strategic
Environmental Research and Development Program for funding this work
under projects SERDP ER- 2220 and ER-2219.
NR 27
TC 7
Z9 7
U1 5
U2 36
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0045-6535
EI 1879-1298
J9 CHEMOSPHERE
JI Chemosphere
PD JAN
PY 2015
VL 119
BP 342
EP 348
DI 10.1016/j.chemosphere.2014.06.050
PG 7
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AY7KQ
UT WOS:000347739600046
PM 25043961
ER
PT J
AU Hughes, BH
Greenberg, NJ
Yang, TC
Skonberg, DI
AF Hughes, Brianna H.
Greenberg, Neil J.
Yang, Tom C.
Skonberg, Denise I.
TI Effects of Rigor Status during High-Pressure Processing on the Physical
Qualities of Farm-Raised Abalone (Haliotis rufescens)
SO JOURNAL OF FOOD SCIENCE
LA English
DT Article
DE abalone; high-pressure processing; rigor; texture
ID GADUS-MORHUA L.; ATLANTIC SALMON; HEAT TREATMENT; SHELF-LIFE; MUSCLE;
STORAGE; COD; PRESSURIZATION; TEMPERATURE; ATTRIBUTES
AB High-pressure processing (HPP) is used to increase meat safety and shelf-life, with conflicting quality effects depending on rigor status during HPP. In the seafood industry, HPP is used to shuck and pasteurize oysters, but its use on abalones has only been minimally evaluated and the effect of rigor status during HPP on abalone quality has not been reported. Farm-raised abalones (Haliotis rufescens) were divided into 12 HPP treatments and 1 unprocessed control treatment. Treatments were processed pre-rigor or post-rigor at 2 pressures (100 and 300 MPa) and 3 processing times (1, 3, and 5 min). The control was analyzed post-rigor. Uniform plugs were cut from adductor and foot meat for texture profile analysis, shear force, and color analysis. Subsamples were used for scanning electron microscopy of muscle ultrastructure. Texture profile analysis revealed that post-rigor processed abalone was significantly (P < 0.05) less firm and chewy than pre-rigor processed irrespective of muscle type, processing time, or pressure. L values increased with pressure to 68.9 at 300 MPa for pre-rigor processed foot, 73.8 for post-rigor processed foot, 90.9 for pre-rigor processed adductor, and 89.0 for post-rigor processed adductor. Scanning electron microscopy images showed fraying of collagen fibers in processed adductor, but did not show pressure-induced compaction of the foot myofibrils. Post-rigor processed abalone meat was more tender than pre-rigor processed meat, and post-rigor processed foot meat was lighter in color than pre-rigor processed foot meat, suggesting that waiting for rigor to resolve prior to processing abalones may improve consumer perceptions of quality and market value.
C1 [Hughes, Brianna H.; Skonberg, Denise I.] Univ Maine, Sch Food & Agr, Orono, ME 04469 USA.
[Greenberg, Neil J.] Univ Maine, Inst Aquaculture Res, Orono, ME 04469 USA.
[Yang, Tom C.] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA.
RP Skonberg, DI (reprint author), Univ Maine, Sch Food & Agr, 5735 Hitchner Hall, Orono, ME 04469 USA.
EM Denise.Skonberg@umit.maine.edu
FU UMaine ADVANCE Rising Tide Center; Aquaculture Research Inst.
FX This manuscript is nr 3394 the Univ. of Maine Agricultural and Forest
Experiment Station. The authors thank Dr. William Halteman, Dr. Seth
Tyler, and Kelly Edwards for sharing their expertise, Anne McCormack,
Marissa Rublee, Katherine Davis-Dentici, Beth Fulton, Richard Lopes, and
Mary Scerra for their invaluable assistance, Brad Buckley and The
Abalone Farm for generously discounting the abalone, and the UMaine
ADVANCE Rising Tide Center and the Aquaculture Research Inst. for
funding portions of this research.
NR 39
TC 0
Z9 0
U1 2
U2 13
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-1147
EI 1750-3841
J9 J FOOD SCI
JI J. Food Sci.
PD JAN
PY 2015
VL 80
IS 1
BP C40
EP C48
DI 10.1111/1750-3841.12717
PG 9
WC Food Science & Technology
SC Food Science & Technology
GA CB0HD
UT WOS:000349305600007
PM 25471900
ER
PT J
AU Ali, SK
Reveles, KR
Davis, R
Mortensen, EM
Frei, CR
Mansi, I
AF Ali, Sayed K.
Reveles, Kelly R.
Davis, Richard
Mortensen, Eric M.
Frei, Christopher R.
Mansi, Ishak
TI The Association of Statin Use and Gonado-Sexual Function in Women: A
Retrospective Cohort Analysis
SO JOURNAL OF SEXUAL MEDICINE
LA English
DT Article
DE Menstrual Disorders; Menopausal Disorders; Infertility; Ovarian
Dysfunction; Sexual Dysfunction; Statin
ID POLYCYSTIC-OVARY-SYNDROME; RANDOMIZED CONTROLLED-TRIALS; HMG-COA
REDUCTASE; QUALITY-OF-LIFE; LIPOPROTEIN CHOLESTEROL; MENOPAUSAL
TRANSITION; ERECTILE DYSFUNCTION; PROPENSITY SCORES; CLINICAL-TRIAL;
HORMONE-LEVELS
AB IntroductionIt has been hypothesized that statins reduce sex hormone biosynthesis through hepatic inhibition of cholesterol synthesis, which is a precursor of androstenedione and estradiol. Such a reduction has been associated with menstrual irregularities, menopausal disorders, infertility, and low libido, but studies are conflicting. Few studies have evaluated the clinical effects of statins on gonadal-sexual function in women.
AimTo compare the risk of gonado-sexual dysfunction in statin users vs. nonusers.
MethodsThis was a retrospective cohort study of all female, adult patients (30-85 years) enrolled in the Tricare Prime/Plus San Antonio catchment area. Using 79 baseline characteristics, we created a propensity score-matched cohort of statin users and nonusers. The study duration was divided into a baseline period (October 1, 2003 to September 30, 2005) to describe patient baseline characteristics and a follow-up period (October 1, 2005 to March 1, 2012) to determine patient outcomes. Statin users were defined as those prescribed a statin for 3 months between October 1, 2004 and September 30, 2005. Logistic regression was used to determine the association of statin use with patient outcomes.
Main Outcome MeasuresOutcomes included menstrual disorders, menopausal disorders, infertility, and ovarian/sexual dysfunction during the follow-up period. Outcomes were identified using inpatient or outpatient InternationalClassification ofDiseases, NinthRevision,ClinicalModification codes as defined by the Agency for Healthcare Research and Quality's Clinical Classifications Software.
ResultsOf 22,706 women who met study criteria, we propensity score-matched 2,890 statin users with 2,890 nonusers; mean age 5812 years. Statin use was not significantly associated with menstrual disorders (OR 0.97; 95% CI 0.81-1.16), menopausal disorders (OR 0.92; 95% CI 0.83-1.02), infertility (OR 0.79; 95% CI 0.36-1.73), or ovarian/sexual dysfunction (OR 1.18; 95% CI 0.83-1.70).
ConclusionsStatin use was not associated with higher risk of gonado-sexual dysfunction in women. Ali SK, Reveles KR, Davis R, Mortensen EM, Frei CR, and Mansi I. The association of statin use and gonado-sexual function in women: A retrospective cohort analysis. J Sex Med 2015;12:83-92.
C1 [Ali, Sayed K.] VA South Texas Hlth Care Syst, Dept Med, San Antonio, TX USA.
[Ali, Sayed K.] Univ Texas Hlth Sci Ctr San Antonio, Div Hosp Med, San Antonio, TX 78229 USA.
[Ali, Sayed K.; Frei, Christopher R.] Univ Texas Austin, Coll Pharm, Pharmacotherapy Div, Austin, TX 78712 USA.
[Reveles, Kelly R.; Frei, Christopher R.] Univ Texas Hlth Sci Ctr, Sch Med, Pharmacotherapy Educ & Res Ctr, San Antonio, TX USA.
[Davis, Richard] Brooke Army Med Ctr, Dept Med, San Antonio, TX USA.
[Mortensen, Eric M.; Mansi, Ishak] VA North Texas Hlth Care Syst, Dept Internal Med, Dallas, TX 75216 USA.
[Mortensen, Eric M.] Univ Texas Southwestern Med Ctr, Dallas, TX USA.
[Mansi, Ishak] Univ Texas Southwestern, Dept Med, Dallas, TX USA.
[Mansi, Ishak] Univ Texas Southwestern, Dept Clin Sci, Div Outcomes & Hlth Serv Res, Dallas, TX USA.
RP Mansi, I (reprint author), VA North Texas Hlth Care Syst, Internal Med Serv, E111,4500 S Lancaster Rd, Dallas, TX 75216 USA.
EM Ishak.Mansi@va.gov
OI Mortensen, Eric/0000-0002-3880-5563
FU NCRR NIH HHS [KL2 RR025766]
NR 49
TC 1
Z9 1
U1 0
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1743-6095
EI 1743-6109
J9 J SEX MED
JI J. Sex. Med.
PD JAN
PY 2015
VL 12
IS 1
BP 83
EP 92
DI 10.1111/jsm.12736
PG 10
WC Urology & Nephrology
SC Urology & Nephrology
GA CA4CO
UT WOS:000348852100010
PM 25382624
ER
PT J
AU Davis, R
Reveles, KR
Ali, SK
Mortensen, EM
Frei, CR
Mansi, I
AF Davis, Richard
Reveles, Kelly R.
Ali, Sayed K.
Mortensen, Eric M.
Frei, Christopher R.
Mansi, Ishak
TI Statins and Male Sexual Health: A Retrospective Cohort Analysis
SO JOURNAL OF SEXUAL MEDICINE
LA English
DT Article
DE Benign Prostatic Hypertrophy; Erectile Dysfunction; Male Infertility;
Testicular Dysfunction; Psychosexual Dysfunction; Statin
ID BENIGN PROSTATIC HYPERPLASIA; QUALITY-OF-LIFE; URINARY-TRACT SYMPTOMS;
ERECTILE-DYSFUNCTION; ATORVASTATIN IMPROVES; CHOLESTEROL LEVELS;
SERUM-CHOLESTEROL; HEART-DISEASE; RISK-FACTORS; DRUG-USE
AB IntroductionConflicting reports exist regarding the role of statins in male gonadal and sexual function. Some studies report a beneficial effect, particularly for erectile dysfunction (ED), through statins' anti-inflammatory and cardiovascular protective properties. Others suggest that statins might be associated with sexual dysfunction through negative effects on hormone levels.
AimThis study aims to compare the risk of gonadal or sexual dysfunction in statin users vs. nonusers in a single-payer healthcare system.
MethodsThis was a retrospective cohort study of all male patients (30-85 years) enrolled in the Tricare San Antonio market. Using 79 baseline characteristics, we created a propensity score-matched cohort of statin users and nonusers. The study duration was divided into a baseline period (October 1, 2003 to September 30, 2005) to describe patient baseline characteristics, and a follow-up period (October 1, 2005 to March 1, 2012) to determine patient outcomes. Statin users were defined as those prescribed a statin for 3 months between October 1, 2004 and September 30, 2005.
Main Outcome MeasuresOutcomes were identified as the occurrence of benign prostatic hypertrophy (BPH), ED, infertility, testicular dysfunction, or psychosexual dysfunction during the follow-up period as identified by inpatient or outpatient InternationalClassification ofDiseases, 9thRevision, ClinicalModification codes. Logistic regression was used to determine the association of statin use with patient outcomes.
ResultsOf 20,731 patients who met study criteria, we propensity score-matched 3,302 statin users with 3,302 nonusers. Statin use in men was not significantly associated with an increased or decreased risk of BPH (odds ratio [OR] 1.08; 95% confidence interval [CI] 0.97-1.19), ED (OR 1.01; 95% CI 0.90-1.13), infertility (OR 1.22; 95% CI 0.66-2.29), testicular dysfunction (OR 0.91; 95% CI 0.73-1.14), or psychosexual dysfunction (OR 1.03; 95% CI 0.94-1.14).
ConclusionsStatin use was not associated with increased risk of being diagnosed with gonadal or sexual dysfunction in men. Further studies using a larger sample may be needed. Davis R, Reveles KR, Ali SK, Mortensen EM, Frei CR, and Mansi I. Statins and male sexual health: A retrospective cohort analysis. J Sex Med 2015;12:158-167.
C1 [Davis, Richard] Brooke Army Med Ctr, Dept Med, Ft Sam Houston, TX 78234 USA.
[Reveles, Kelly R.; Frei, Christopher R.] Univ Texas Austin, Coll Pharm, Pharmacotherapy Div, Austin, TX 78712 USA.
[Reveles, Kelly R.; Frei, Christopher R.] Univ Texas Hlth Sci Ctr San Antonio, Sch Med, Pharmacotherapy Educ & Res Ctr, San Antonio, TX 78229 USA.
[Ali, Sayed K.] Univ Texas Hlth Sci Ctr San Antonio, VA South Texas Hlth Care Syst, San Antonio, TX 78229 USA.
[Mortensen, Eric M.; Mansi, Ishak] VA North Texas Hlth Care Syst, Dallas, TX USA.
[Mortensen, Eric M.; Mansi, Ishak] Univ Texas Southwestern, Div Outcomes & Hlth Serv Res, Dept Med & Clin Sci, Dallas, TX USA.
OI Mortensen, Eric/0000-0002-3880-5563
FU NCATS NIH HHS [KL2 TR001118, UL1 TR001120]; NCRR NIH HHS [KL2 RR025766]
NR 55
TC 6
Z9 6
U1 0
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1743-6095
EI 1743-6109
J9 J SEX MED
JI J. Sex. Med.
PD JAN
PY 2015
VL 12
IS 1
BP 158
EP 167
DI 10.1111/jsm.12745
PG 10
WC Urology & Nephrology
SC Urology & Nephrology
GA CA4CO
UT WOS:000348852100018
PM 25421152
ER
PT J
AU Lee, G
Varanasi, CV
Liu, J
AF Lee, Gyeonghee
Varanasi, Chakrapani V.
Liu, Jie
TI Effects of morphology and chemical doping on electrochemical properties
of metal hydroxides in pseudocapacitors
SO NANOSCALE
LA English
DT Article
ID ADVANCED ENERGY-CONVERSION; SUPERCAPACITOR ELECTRODES; NICKEL-HYDROXIDE;
PERFORMANCE; STORAGE; NANOPARTICLES; GLUCOSE; NANOSTRUCTURE;
CONDUCTIVITY; BEHAVIOR
AB It is well known that both the structural morphology and chemical doping are important factors that affect the properties of metal hydroxide materials in electrochemical energy storage devices. In this work, an effective method to tailor the morphology and chemical doping of metal hydroxides is developed. It is shown that the morphology and the degree of crystallinity of Ni(OH)(2) can be changed by adding glucose in the ethanol-mediated solvothermal synthesis. Ni(OH)(2) produced in this manner exhibited an increased specific capacitance, which is partially attributed to its increased surface area. Interestingly, the effect of morphology on cobalt doped-Ni(OH)(2) is found to be more effective at low cobalt contents than at high cobalt contents in terms of improving the electrochemical performance. This result reveals the existence of competitive effects between chemical doping and morphology change. These findings will provide important insights to design effective materials for energy storage devices.
C1 [Lee, Gyeonghee; Liu, Jie] Duke Univ, Dept Chem, Durham, NC 27708 USA.
[Varanasi, Chakrapani V.] Army Res Off, Durham, NC 27703 USA.
RP Varanasi, CV (reprint author), Army Res Off, Durham, NC 27703 USA.
EM chakrapani.v.varanasi.civ@mail.mil; j.liu@duke.edu
RI Liu, Jie/B-4440-2010
OI Liu, Jie/0000-0003-0451-6111
FU Army Research Office (ARO) [W911NF-04-D-0001]; Duke SMIF (Shared
Materials Instrumentation Facilities)
FX This work was supported by a research grant from Army Research Office
(ARO) under contract W911NF-04-D-0001. However, any opinions, findings,
conclusions or recommendations expressed in this material are those of
the author(s) and do not necessarily reflect the views of the ARO. The
authors also acknowledge the help of Minhee Lee in NMR analysis and the
support from Duke SMIF (Shared Materials Instrumentation Facilities).
NR 37
TC 14
Z9 14
U1 7
U2 41
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 2040-3364
EI 2040-3372
J9 NANOSCALE
JI Nanoscale
PY 2015
VL 7
IS 7
BP 3181
EP 3188
DI 10.1039/c4nr06997h
PG 8
WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials
Science, Multidisciplinary; Physics, Applied
SC Chemistry; Science & Technology - Other Topics; Materials Science;
Physics
GA CB2QQ
UT WOS:000349473200044
PM 25615929
ER
PT J
AU Linkov, I
Massey, O
Keisler, J
Rusyn, I
Hartung, T
AF Linkov, Igor
Massey, Olivia
Keisler, Jeff
Rusyn, Ivan
Hartung, Thomas
TI From "Weight of Evidence" to Quantitative Data Integration using
Multicriteria Decision Analysis and Bayesian Methods
SO ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION
LA English
DT Article
DE weight of evidence; decision analysis; Bayesian; toxicology; policy
ID EVIDENCE-BASED TOXICOLOGY; SKIN SENSITIZATION; TESTING STRATEGIES;
OSIRIS WEIGHT; THOUGHT; FOOD; NANOMATERIALS; PROBABILITY; ASSESSMENTS;
INFORMATION
AB "Weighing" available evidence in the process of decision-making is unavoidable, yet it is one step that routinely raises suspicions: what evidence should be used, how much does it weigh, and whose thumb may be tipping the scales? This commentary aims to evaluate the current state and future roles of various types of evidence for hazard assessment as it applies to environmental health. In its recent evaluation of the US Environmental Protection Agency's Integrated Risk Information System assessment process, the National Research Council committee singled out the term "weight of evidence" (WoE) for critique, deeming the process too vague and detractive to the practice of evaluating human health risks of chemicals. Moving the methodology away from qualitative, vague and controversial methods towards generalizable, quantitative and transparent methods for appropriately managing diverse lines of evidence is paramount for both regulatory and public acceptance of the hazard assessments. The choice of terminology notwithstanding, a number of recent Bayesian WoE-based methods, the emergence of multi criteria decision analysis for WoE applications, as well as the general principles behind the foundational concepts of WoE, show promise in how to move forward and regain trust in the data integration step of the assessments. We offer our thoughts on the current state of WoE as a whole and while we acknowledge that many WoE applications have been largely qualitative and subjective in nature, we see this as an opportunity to turn WoE towards a quantitative direction that includes Bayesian and multi criteria decision analysis.
C1 [Linkov, Igor; Massey, Olivia] US Army, Engn Res & Dev Ctr, Concord, MA 01742 USA.
[Massey, Olivia] MIT, Cambridge, MA 02139 USA.
[Keisler, Jeff] Univ Massachusetts, Boston, MA 02125 USA.
[Rusyn, Ivan] Texas A&M Univ, College Stn, TX USA.
[Hartung, Thomas] Johns Hopkins Bloomberg Sch Publ Hlth, Ctr Alternat Anim Testing, Baltimore, MD USA.
[Hartung, Thomas] Univ Konstanz, Ctr Alternat Anim Testing Europe, Constance, Germany.
RP Linkov, I (reprint author), US Army, Engn Res & Dev Ctr, Concord, MA 01742 USA.
EM Igor.Linkov@usace.army.mil
RI Rusyn, Ivan/S-2426-2016
FU USACE Dredging Operations and Environmental Research program
FX The authors acknowledge funding from the USACE Dredging Operations and
Environmental Research program. The authors thank Dr Todd Bridges as
program manager and Mr Matthew Bates for comments and discussions.
NR 34
TC 11
Z9 11
U1 0
U2 9
PU SPEKTRUM AKADEMISCHER VERLAG-SPRINGER-VERLAG GMBH
PI HEILDEBERG
PA TIERGARTENSTRASSE 17, HEILDEBERG, 69121, GERMANY
SN 1868-596X
EI 1868-8551
J9 ALTEX-ALTERN ANIM EX
JI ALTEX-Altern. Anim. Exp.
PY 2015
VL 32
IS 1
BP 3
EP 8
PG 6
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA CA5QM
UT WOS:000348962900002
PM 25592482
ER
PT S
AU Kim, JH
Excler, JL
Michael, NL
AF Kim, Jerome H.
Excler, Jean-Louis
Michael, Nelson L.
BE Caskey, CT
TI Lessons from the RV144 Thai Phase III HIV-1 Vaccine Trial and the Search
for Correlates of Protection
SO ANNUAL REVIEW OF MEDICINE, VOL 66
SE Annual Review of Medicine
LA English
DT Review; Book Chapter
DE efficacy; correlates of risk; nonneutralizing antibody; neutralizing
antibody; antibody-dependent cytotoxicity; envelope; HIV vaccine
ID HUMAN-IMMUNODEFICIENCY-VIRUS; BROADLY NEUTRALIZING ANTIBODIES;
RECOMBINANT GLYCOPROTEIN-120 VACCINE; CELL-MEDIATED-IMMUNITY; EFFICACY
TRIAL; RHESUS-MONKEYS; DOUBLE-BLIND; GAG/POL/NEF VACCINE; ALVAC-HIV;
ANTIRETROVIRAL PROPHYLAXIS
AB RV144 remains the only HIV-1 vaccine trial to demonstrate efficacy against HIV-1 acquisition. The prespecified analysis of immune correlates of risk showed that antibodies directed against the V1V2 region of gp120, in particular the IgG1 and IgG3 subclass mediating antibody-dependent cell-mediated cytotoxicity, seem to play a predominant role in protection against HIV-1 acquisition and that plasma envelope (Env)-specific IgA antibodies were directly correlated with risk. RV144 and recent nonhuman primate challenge studies suggest that Env is essential, and perhaps sufficient, to induce protective antibody responses against mucosal HIV-1 acquisition. Follow-up clinical trials are ongoing to further dissect the immune responses elicited by the RV144 ALVAC-HIV and AIDSVAXR (R) B/E regimen. The study of gp120 Env immunogens and immune correlates of risk has resulted in the development of improved antigens. Whether the RV144 immune correlates of risk will generalize to other populations vaccinated with similar immunogens with different modes and intensity of transmission remains to be demonstrated. Efficacy trials are now planned in heterosexual populations in southern Africa and men who have sex with men in Thailand.
C1 [Kim, Jerome H.; Excler, Jean-Louis; Michael, Nelson L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA.
[Excler, Jean-Louis] Henry M Jackson Fdn, US Mil HIV Res Program, Bethesda, MD 20817 USA.
RP Kim, JH (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA.
EM jkim@hivresearch.org; jexcler@hivresearch.org; nmichael@hivresearch.org
FU NIAID NIH HHS [Y1-AI-2642-12]
NR 96
TC 26
Z9 26
U1 2
U2 19
PU ANNUAL REVIEWS
PI PALO ALTO
PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0897 USA
SN 0066-4219
BN 978-0-8243-0566-6
J9 ANNU REV MED
JI Annu. Rev. Med.
PY 2015
VL 66
BP 423
EP 437
DI 10.1146/annurev-med-052912-123749
PG 15
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA BB9PT
UT WOS:000348560300028
PM 25341006
ER
PT J
AU Singh, B
Crippen, T
Zheng, LY
Fields, AT
Yu, ZN
Ma, Q
Wood, TK
Dowd, SE
Flores, M
Tomberlin, JK
Tarone, AM
AF Singh, Baneshwar
Crippen, Tawni L.
Zheng, Longyu
Fields, Andrew T.
Yu, Ziniu
Ma, Qun
Wood, Thomas K.
Dowd, Scot E.
Flores, Micah
Tomberlin, Jeffery K.
Tarone, Aaron M.
TI A metagenomic assessment of the bacteria associated with Lucilia
sericata and Lucilia cuprina (Diptera: Calliphoridae)
SO APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
LA English
DT Article
DE Microbial community; Blow flies; Maggot debridement therapy; Salivary
gland; 454 sequencing
ID RIBOSOMAL-RNA SEQUENCES; MAGGOT THERAPY; FLIES DIPTERA;
STAPHYLOCOCCUS-AUREUS; ANTIBIOTIC-RESISTANT; FORENSIC ENTOMOLOGY;
MAXIMUM-LIKELIHOOD; BIOFILM FORMATION; DIGESTIVE-TRACT; MUSCA-DOMESTICA
AB Lucilia Robineau-Desvoidy (Diptera: Calliphoridae) is a blow fly genus of forensic, medical, veterinary, and agricultural importance. This genus is also famous because of its beneficial uses in maggot debridement therapy (MDT). Although the genus is of considerable economic importance, our knowledge about microbes associated with these flies and how these bacteria are horizontally and trans-generationally transmitted is limited. In this study, we characterized bacteria associated with different life stages of Lucilia sericata (Meigen) and Lucilia cuprina (Wiedemann) and in the salivary gland of L. sericata by using 16S rDNA 454 pyrosequencing. Bacteria associated with the salivary gland of L. sericata were also characterized using light and transmission electron microscopy (TEM). Results from this study suggest that the majority of bacteria associated with these flies belong to phyla Proteobacteria, Firmicutes, and Bacteroidetes, and most bacteria are maintained intragenerationally, with a considerable degree of turnover from generation to generation. In both species, second-generation eggs exhibited the highest bacterial phylum diversity (20 % genetic distance) than other life stages. The Lucilia sister species shared the majority of their classified genera. Of the shared bacterial genera, Providencia, Ignatzschineria, Lactobacillus, Lactococcus, Vagococcus, Morganella, and Myroides were present at relatively high abundances. Lactobacillus, Proteus, Diaphorobacter, and Morganella were the dominant bacterial genera associated with a survey of the salivary gland of L. sericata. TEM analysis showed a sparse distribution of both Gram-positive and Gram-negative bacteria in the salivary gland of L. sericata. There was more evidence for horizontal transmission of bacteria than there was for trans-generational inheritance. Several pathogenic genera were either amplified or reduced by the larval feeding on decomposing liver as a resource. Overall, this study provides information on bacterial communities associated with different life stages of Lucilia and their horizontal and trans-generational transmission, which may help in the development of better vector-borne disease management and MDT methods.
C1 [Singh, Baneshwar; Zheng, Longyu; Fields, Andrew T.; Flores, Micah; Tomberlin, Jeffery K.; Tarone, Aaron M.] Texas A&M Univ, Dept Entomol, College Stn, TX 77843 USA.
[Singh, Baneshwar] Virginia Commonwealth Univ, Dept Forens Sci, Richmond, VA 23284 USA.
[Crippen, Tawni L.; Zheng, Longyu] ARS, Southern Plains Agr Res Ctr, USDA, College Stn, TX USA.
[Zheng, Longyu; Yu, Ziniu] Huazhong Agr Univ, Natl Engn Res Ctr Microbe Pesticide, State Key Lab Agr Microbiol, Wuhan, Peoples R China.
[Fields, Andrew T.] SUNY Stony Brook, Sch Marine & Atmospher Sci, Stony Brook, NY 11794 USA.
[Ma, Qun] Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Tianjin, Peoples R China.
[Wood, Thomas K.] Penn State Univ, Dept Chem Engn, University Pk, PA 16802 USA.
[Dowd, Scot E.] MR DNA Mol Res LP, Shallowater, TX USA.
[Flores, Micah] Walter Reed Army Inst Res, Silver Spring, MD USA.
RP Singh, B (reprint author), Virginia Commonwealth Univ, Dept Forens Sci, 1015 Floyd Ave, Richmond, VA 23284 USA.
EM bsingh@vcu.edu
OI Tarone, Aaron/0000-0003-0965-7634; Wood, Thomas/0000-0002-6258-529X
FU Texas Agrilife Research; College of Agriculture and Life Sciences at
Texas A&M University, College Station, TX; National Institute of
Justice, Office of Justice Programs, U.S. Department of Justice
[2010-DN-BX-K243]; College of Humanities and Sciences of Virginia
Commonwealth University, Richmond, VA
FX The authors would like to thank Dr. Robert Droleskey for his assistance
with transmission electron microscopy of the salivary gland. Funding for
B.S., A.M.T., L.Z., A.T.F., M.F., and J.K.T. was provided partially by
the Texas Agrilife Research and the College of Agriculture and Life
Sciences at Texas A&M University, College Station, TX. Additional
funding for B.S., A.M.T., T.L.C., and J.K.T. was provided by the
National Institute of Justice, Office of Justice Programs, U.S.
Department of Justice through Grant 2010-DN-BX-K243. B.S. was also
supported by a start up fund from the College of Humanities and Sciences
of Virginia Commonwealth University, Richmond, VA. We also thank
anonymous reviewers for their suggestions that improved this article
substantially. Points of view in this document are those of the authors
and do not necessarily represent the official position or policies of
the U.S. Department of Justice, Department of the Army, Department of
Defense, or U.S. Government. Mention of trade names, companies, or
commercial products in this publication is solely for the purpose of
providing specific information and does not imply recommendation or
endorsement of the products by the U.S. Department of Agriculture.
NR 85
TC 12
Z9 12
U1 7
U2 33
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0175-7598
EI 1432-0614
J9 APPL MICROBIOL BIOT
JI Appl. Microbiol. Biotechnol.
PD JAN
PY 2015
VL 99
IS 2
BP 869
EP 883
DI 10.1007/s00253-014-6115-7
PG 15
WC Biotechnology & Applied Microbiology
SC Biotechnology & Applied Microbiology
GA CA2YB
UT WOS:000348770900027
PM 25306907
ER
PT J
AU Cesur, R
Sabia, JJ
Tekin, E
AF Cesur, Resul
Sabia, Joseph J.
Tekin, Erdal
TI Combat exposure and migraine headache: Evidence from exogenous
deployment assignment
SO ECONOMICS & HUMAN BIOLOGY
LA English
DT Article
DE Migraine headache; Combat exposure; Sleep disruption
ID TRAUMATIC BRAIN-INJURY; MILITARY SERVICE; UNITED-STATES;
EDUCATIONAL-ATTAINMENT; HEALTH; IMPACT; PREVALENCE; VETERANS; BURDEN;
EPIDEMIOLOGY
AB Migraine headache is a growing problem for U.S. servicemembers deployed to Iraq and Afghanistan and has been linked to substantial negative socioeconomic consequences. However, there has been no comprehensive examination of the relationship between combat exposure and migraine headache or its stress-related triggers. Analyzing data drawn from the National Longitudinal Study of Adolescent Health, we use exogenous variation in deployment assignment to estimate the effect of combat exposure on migraine headache. We find that those deployed to a combat zone with enemy firefight are at substantially increased risk for migraine headache relative to those deployed to non-combat zones outside the United States or to combat zones without enemy firefight. We find that combat-induced sleep disorders, stress-related psychological problems, and physical injuries in combat explain approximately 40-45 percent of the relationship between combat exposure and migraine headache. (C) 2014 Published by Elsevier B.V.
C1 [Cesur, Resul] Univ Connecticut, Dept Finance, Sch Business, Storrs, CT 06269 USA.
[Sabia, Joseph J.] San Diego State Univ, San Diego, CA 92182 USA.
[Sabia, Joseph J.] US Mil Acad, Dept Econ, San Diego, CA 92182 USA.
[Tekin, Erdal] Georgia State Univ, IZA, Atlanta, GA 30303 USA.
RP Sabia, JJ (reprint author), San Diego State Univ, 5500 Campanile Dr, San Diego, CA 92182 USA.
EM cesur@business.uconn.edu; jsabia@mail.sdsu.edu; tekin@gsu.edu
NR 46
TC 2
Z9 2
U1 1
U2 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1570-677X
EI 1873-6130
J9 ECON HUM BIOL
JI Econ. Hum. Biol.
PD JAN
PY 2015
VL 16
BP 81
EP 99
DI 10.1016/j.ehb.2014.01.001
PG 19
WC Economics; Public, Environmental & Occupational Health
SC Business & Economics; Public, Environmental & Occupational Health
GA CA5OW
UT WOS:000348958700007
PM 24560382
ER
PT J
AU Newman, AJ
Clark, MP
Sampson, K
Wood, A
Hay, LE
Bock, A
Viger, RJ
Blodgett, D
Brekke, L
Arnold, JR
Hopson, T
Duan, Q
AF Newman, A. J.
Clark, M. P.
Sampson, K.
Wood, A.
Hay, L. E.
Bock, A.
Viger, R. J.
Blodgett, D.
Brekke, L.
Arnold, J. R.
Hopson, T.
Duan, Q.
TI Development of a large-sample watershed-scale hydrometeorological data
set for the contiguous USA: data set characteristics and assessment of
regional variability in hydrologic model performance
SO HYDROLOGY AND EARTH SYSTEM SCIENCES
LA English
DT Article
ID RAINFALL-RUNOFF MODELS; CONTERMINOUS UNITED-STATES; DAILY
SOLAR-RADIATION; LAND-SURFACE FLUXES; PARAMETER-ESTIMATION; GLOBAL
OPTIMIZATION; QUALITY-ASSURANCE; TEMPERATURE DATA; COMPLEX TERRAIN;
PRECIPITATION
AB We present a community data set of daily forcing and hydrologic response data for 671 small- to medium-sized basins across the contiguous United States (median basin size of 336 km(2)) that spans a very wide range of hydroclimatic conditions. Area-averaged forcing data for the period 1980-2010 was generated for three basin spatial configurations - basin mean, hydrologic response units (HRUs) and elevation bands - by mapping daily, gridded meteorological data sets to the subbasin (Daymet) and basin polygons (Daymet, Maurer and NLDAS). Daily streamflow data was compiled from the United States Geological Survey National Water Information System. The focus of this paper is to (1) present the data set for community use and (2) provide a model performance benchmark using the coupled Snow-17 snow model and the Sacramento Soil Moisture Accounting Model, calibrated using the shuffled complex evolution global optimization routine. After optimization minimizing daily root mean squared error, 90% of the basins have Nash-Sutcliffe efficiency scores >= 0.55 for the calibration period and 34% >= 0.8. This benchmark provides a reference level of hydrologic model performance for a commonly used model and calibration system, and highlights some regional variations in model performance. For example, basins with a more pronounced seasonal cycle generally have a negative low flow bias, while basins with a smaller seasonal cycle have a positive low flow bias. Finally, we find that data points with extreme error (defined as individual days with a high fraction of total error) are more common in arid basins with limited snow and, for a given aridity, fewer extreme error days are present as the basin snow water equivalent increases.
C1 [Newman, A. J.; Clark, M. P.; Sampson, K.; Wood, A.; Hopson, T.] Natl Ctr Atmospher Res, Boulder, CO 80307 USA.
[Hay, L. E.; Bock, A.; Viger, R. J.] US Geol Survey, Lakewood, CO 80225 USA.
[Blodgett, D.] US Geol Survey, Ctr Integrated Data Analyt, Middleton, WI USA.
[Brekke, L.] US Dept Interior, Bur Reclamat, Denver, CO USA.
[Arnold, J. R.] US Army Corps Engineers, Inst Water Resources, Seattle, WA USA.
[Duan, Q.] Beijing Normal Univ, Beijing 100875, Peoples R China.
RP Newman, AJ (reprint author), Natl Ctr Atmospher Res, POB 3000, Boulder, CO 80307 USA.
EM anewman@ucar.edu
RI Clark, Martyn/A-5560-2015; Duan, Qingyun/C-7652-2011
OI Clark, Martyn/0000-0002-2186-2625; Duan, Qingyun/0000-0001-9955-1512
FU US Army Corps of Engineers Climate Preparedness and Resilience Programs;
US Department of the Interior Bureau of Reclamation
FX This work is funded by the US Army Corps of Engineers Climate
Preparedness and Resilience Programs and the US Department of the
Interior Bureau of Reclamation. The authors would like to thank the USGS
Modeling of Watershed Systems (MoWS) group, specifically for providing
technical support and the national geospatial fabric data to generate
all the basin spatial configurations. We would also like to thank Jordan
Read and Tom Kunicki of the USGS Center for Integrated Data Analytics
for their help with the USGS Geodata Portal.
NR 80
TC 16
Z9 16
U1 1
U2 14
PU COPERNICUS GESELLSCHAFT MBH
PI GOTTINGEN
PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY
SN 1027-5606
EI 1607-7938
J9 HYDROL EARTH SYST SC
JI Hydrol. Earth Syst. Sci.
PY 2015
VL 19
IS 1
BP 209
EP 223
DI 10.5194/hess-19-209-2015
PG 15
WC Geosciences, Multidisciplinary; Water Resources
SC Geology; Water Resources
GA CA5EA
UT WOS:000348929800012
ER
PT J
AU Rafaels, KA
Cutcliffe, HC
Salzar, RS
Davis, M
Boggess, B
Bush, B
Harris, R
Rountree, MS
Sanderson, E
Campman, S
Koch, S
Bass, CR
AF Rafaels, Karin A.
Cutcliffe, Hattie C.
Salzar, Robert S.
Davis, Martin
Boggess, Brian
Bush, Bryan
Harris, Robert
Rountree, Mark Steve
Sanderson, Ellory
Campman, Steven
Koch, Spencer
Bass, Cameron R. Dale
TI Injuries of the Head from Backface Deformation of Ballistic Protective
Helmets Under Ballistic Impact
SO JOURNAL OF FORENSIC SCIENCES
LA English
DT Article
DE forensic science; head injury; ballistic injury; biomechanics; helmet
deformation; backface deformation
ID AGE-RELATED-CHANGES; CORTICAL BONE; RELATIVE IMPORTANCE;
TENSILE-STRENGTH; DENSITY; ARMY
AB Modern ballistic helmets defeat penetrating bullets by energy transfer from the projectile to the helmet, producing helmet deformation. This deformation may cause severe injuries without completely perforating the helmet, termed behind armor blunt trauma (BABT). As helmets become lighter, the likelihood of larger helmet backface deformation under ballistic impact increases. To characterize the potential for BABT, seven postmortem human head/neck specimens wearing a ballistic protective helmet were exposed to nonperforating impact, using a 9mm, full metal jacket, 124 grain bullet with velocities of 400-460m/s. An increasing trend of injury severity was observed, ranging from simple linear fractures to combinations of linear and depressed fractures. Overall, the ability to identify skull fractures resulting from BABT can be used in forensic investigations. Our results demonstrate a high risk of skull fracture due to BABT and necessitate the prevention of BABT as a design factor in future generations of protective gear.
C1 [Rafaels, Karin A.; Salzar, Robert S.; Davis, Martin; Boggess, Brian; Bush, Bryan] Univ Virginia, Ctr Appl Biomech, Charlottesville, VA 22911 USA.
[Cutcliffe, Hattie C.; Bass, Cameron R. Dale] Duke Univ, Injury Biomech Lab, Dept Biomed Engn, Durham, NC 27708 USA.
[Harris, Robert] Emory Univ, Atlanta, GA 30329 USA.
[Rountree, Mark Steve] Johns Hopkins Univ, Appl Phys Lab, Laurel, MD 20723 USA.
[Sanderson, Ellory] US Army, Aberdeen Test Ctr, CSTE DTC AT CS BD, Aberdeen Proving Ground, MD 21005 USA.
[Campman, Steven] San Diego Cty Med Examiners Off, San Diego, CA 92123 USA.
[Koch, Spencer] Duke Univ, Med Ctr, Dept Radiol, Durham, NC 27710 USA.
RP Cutcliffe, HC (reprint author), Duke Univ, Injury Biomech Lab, Dept Biomed Engn, 136 Hudson Hall,Box 90281, Durham, NC 27708 USA.
EM hattie.cutcliffe@duke.edu
FU Natick Soldier Center; Armed Forces Institute of Pathology; Uniformed
Services University of the Health Sciences; Walter Reed Army Medical
Center
FX Support provided by the Natick Soldier Center, The Armed Forces
Institute of Pathology, The Uniformed Services University of the Health
Sciences and Mr. George Holborow, and the Walter Reed Army Medical
Center.
NR 20
TC 4
Z9 5
U1 3
U2 18
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-1198
EI 1556-4029
J9 J FORENSIC SCI
JI J. Forensic Sci.
PD JAN
PY 2015
VL 60
IS 1
BP 219
EP 225
DI 10.1111/1556-4029.12570
PG 7
WC Medicine, Legal
SC Legal Medicine
GA AZ8AR
UT WOS:000348437700033
PM 25039407
ER
PT J
AU Chapman, DP
Liu, Y
McKnight-Eily, LR
Croft, JB
Holt, JB
Balkin, TJ
Giles, WH
AF Chapman, Daniel P.
Liu, Yong
McKnight-Eily, Lela R.
Croft, Janet B.
Holt, James B.
Balkin, Thomas J.
Giles, Wayne H.
TI Daily Insufficient Sleep and Active Duty Status
SO MILITARY MEDICINE
LA English
DT Article
ID POSTTRAUMATIC-STRESS-DISORDER; U.S. MILITARY VETERANS; SERVICE MEMBERS;
US ADULTS; COMBAT; PERSONNEL; SYMPTOMS; ASSOCIATION; DEPLOYMENT;
BEHAVIORS
AB Objective: We assessed the relationship between active duty status and daily insufficient sleep in a telephone survey. Methods: U.S. military service status (recent defined as past 12 months and past defined as >12 months ago) and daily insufficient sleep in the past 30 days were assessed among 566,861 adults aged 18 to 64 years and 271,202 adults aged >= 65 years in the 2009 to 2010 Behavioral Risk Factor Surveillance System surveys. Results: Among ages 18 to 64 years, 1.1% reported recent active duty and 7.1% had past service; among ages >= 65 years, 0.6% reported recent and 24.6% had past service. Among ages 18 to 64 years, prevalence of daily insufficient sleep was 13.7% among those reporting recent duty, 12.6% for those with past service, and 11.2% for those with no service. Insufficient sleep did not vary significantly with active duty status among ages >= 65 years. After adjustment for sociodemographic characteristics, health behaviors, and frequent mental distress in multivariate logistic regression models, respondents aged 18 to 64 years with recent active duty were 34% more likely and those with past service were 23% more likely to report daily insufficient sleep than those with no service (p < 0.05, both). Conclusions: Adults with either recent or past active duty have a greater risk for daily insufficient sleep.
C1 [Chapman, Daniel P.; Liu, Yong; McKnight-Eily, Lela R.; Croft, Janet B.; Holt, James B.; Giles, Wayne H.] Natl Ctr Chron Dis Prevent & Hlth Promot, Ctr Dis Control & Prevent, Div Populat Hlth, Epidemiol & Surveillance Branch, Atlanta, GA 30341 USA.
[Balkin, Thomas J.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Dept Behav Biol, Silver Spring, MD 20910 USA.
RP Chapman, DP (reprint author), Natl Ctr Chron Dis Prevent & Hlth Promot, Ctr Dis Control & Prevent, Div Populat Hlth, Epidemiol & Surveillance Branch, 4770 Buford Highway Northeast,Mailstop K-78, Atlanta, GA 30341 USA.
NR 39
TC 0
Z9 0
U1 1
U2 4
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD JAN
PY 2015
VL 180
IS 1
BP 68
EP 76
DI 10.7205/MILMED-D-14-00158
PG 9
WC Medicine, General & Internal
SC General & Internal Medicine
GA CA7MM
UT WOS:000349101400028
PM 25562860
ER
PT J
AU Hill, SW
AF Hill, Steven W.
TI US Army Hospital Ship "Relief"
SO MILITARY MEDICINE
LA English
DT Editorial Material
C1 Natl Museum Hlth & Med, US Army Med Res & Mat Command, Silver Spring, MD 20910 USA.
RP Hill, SW (reprint author), Natl Museum Hlth & Med, US Army Med Res & Mat Command, 2500 Linden Lane, Silver Spring, MD 20910 USA.
NR 2
TC 1
Z9 1
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD JAN
PY 2015
VL 180
IS 1
BP 118
EP 118
DI 10.7205/MILMED-D-14-00458
PG 1
WC Medicine, General & Internal
SC General & Internal Medicine
GA CA7MM
UT WOS:000349101400035
PM 25562867
ER
PT J
AU Bateman, JA
Chang, A
Capo-Aponte, J
AF Bateman, Jennifer A.
Chang, Amy
Capo-Aponte, Jose
TI Cerebellar Ischemia Manifesting As Vertical Diplopia: A Case Study on
Skew Deviation
SO MILITARY MEDICINE
LA English
DT Article
ID VERTEBRAL ARTERY DISSECTION; CHIROPRACTIC MANIPULATION; RISK-FACTOR;
STROKE; DIFFERENTIATE
AB Purpose: Skew deviation mimics superior oblique palsy. Associated findings can include ocular torsion, head tilt, headache, and neurologic symptoms that may help localize the responsible intracranial lesion. Accurate diagnosis is essential in determining and treating the underlying cause. Imaging options will be reviewed. Case Report: A 29-year-old white male presented to the emergency room with sudden onset vertical diplopia after self-neck manipulation. An ophthalmic evaluation led to the diagnosis of skew deviation. Diagnostic imaging revealed an infarct of the cerebellum likely secondary to a vertebral artery dissection. Besides neck manipulation, other possible contributing factors include smoking, elevated cholesterol, and elevated testosterone. Symptoms resolved within 24 hours and the patient was treated with aspirin and atorvastatin calcium. Conclusions: Skew deviation must be a consideration in patients with vertical diplopia, and ruled out before a superior oblique palsy diagnosis. Vertebral artery dissections are uncommon in the general population but can account for up to 25% of ischemic strokes in the young and middle-aged. Smoking, high cholesterol, and high testosterone are known risk factors of stroke. Research is inconclusive on spinal manipulation's relation to stroke. This report presents an example of neck manipulation directly preceding skew deviation secondary to stroke.
C1 [Bateman, Jennifer A.; Chang, Amy; Capo-Aponte, Jose] Womack Army Med Ctr, Dept Optometry, Ft Bragg, NC 28310 USA.
RP Bateman, JA (reprint author), Womack Army Med Ctr, Dept Optometry, 2817 Reilly Rd, Ft Bragg, NC 28310 USA.
NR 24
TC 0
Z9 0
U1 0
U2 3
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD JAN
PY 2015
VL 180
IS 1
BP E168
EP E173
DI 10.7205/MILMED-D-14-00292
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA CA7MM
UT WOS:000349101400013
PM 25562880
ER
PT J
AU Freeman, R
Lenz, B
AF Freeman, Randall
Lenz, Brittany
TI Cutaneous Reactions Associated With ACAM2000 Smallpox Vaccination in a
Deploying US Army Unit
SO MILITARY MEDICINE
LA English
DT Article
ID ADVERSE EVENTS; VACCINIA; STATES
AB Since 2003, the U. S. Army has vaccinated deploying troops for smallpox. In 2008, the U. S. military transitioned to the second-generation vaccine ACAM2000. Cutaneous adverse events associated with this vaccine are rarely characterized. We review the medical literature on cutaneous adverse events with ACAM2000 and describe four new cases that occurred in primary vaccinees at Fort Wainwright, Alaska. Four cases of disseminated papulovesicular lesions occurred out of 500 smallpox vaccinations given at Fort Wainwright, Alaska. Each case was followed by dermatology and preventive medicine. Biopsy specimens were examined at Walter Reed Army Medical Center and the U. S. Centers for Disease Control and Prevention. Three of the cases had variable clinical history of dermatitis. Case 1 experienced the most extensive lesions and case duration, and Case 4 the least. All biopsy sample results confirmed immune-mediated hypersensitivity. This study relied on self-reporting and on surveillance by unit medical staff to identify cases. Each case also received multiple other concurrent vaccinations. Further study is needed to increase our knowledge of these cutaneous reactions and demonstrate possible associated or causal factors.
C1 [Freeman, Randall] US Army, ATTN AHRC SG, Human Resources Command, Fort Knox, KY 40122 USA.
[Lenz, Brittany] 22nd Med Grp, McConnell AFB, KS 67221 USA.
RP Freeman, R (reprint author), US Army, ATTN AHRC SG, Human Resources Command, 1600 Spearhead Div Ave, Fort Knox, KY 40122 USA.
NR 15
TC 0
Z9 0
U1 0
U2 6
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD JAN
PY 2015
VL 180
IS 1
BP E152
EP E156
DI 10.7205/MILMED-D-14-00218
PG 5
WC Medicine, General & Internal
SC General & Internal Medicine
GA CA7MM
UT WOS:000349101400009
PM 25562876
ER
PT J
AU Gee, S
Dunn, J
Waterman, B
Todd, M
AF Gee, Shawn
Dunn, John
Waterman, Brian
Todd, Michael
TI Orthobiological Augmentation of Consecutive Rotator Cuff Repair Failure
and Deltoid Dehiscence
SO MILITARY MEDICINE
LA English
DT Article
ID MEDIAL COLLATERAL LIGAMENT; SMALL-INTESTINAL SUBMUCOSA; SURGICAL REPAIR;
DETACHMENT; TEARS
AB We present a case of postsurgical deltoid insufficiency occurring after augmented revision of a failed prior rotator cuff repair. Revision deltoid repair with deltoid imbrication and orthobiological augmentation was dually performed, resulting in successful deltoid and rotator cuff healing and improved clinical outcomes.
C1 [Gee, Shawn] Tripler Army Med Ctr, Dept Orthopaed Surg, Honolulu, HI 96819 USA.
[Dunn, John; Waterman, Brian; Todd, Michael] William Beaumont Army Med Ctr, Dept Orthopaed Surg, El Paso, TX 79920 USA.
RP Gee, S (reprint author), Tripler Army Med Ctr, Dept Orthopaed Surg, 459 Patterson Rd, Honolulu, HI 96819 USA.
NR 13
TC 0
Z9 0
U1 0
U2 1
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD JAN
PY 2015
VL 180
IS 1
BP E142
EP E144
DI 10.7205/MILMED-D-14-00251
PG 3
WC Medicine, General & Internal
SC General & Internal Medicine
GA CA7MM
UT WOS:000349101400006
PM 25562873
ER
PT J
AU Ore, MRM
Lynch, D
Rumsey, C
AF Ore, Maj Robert M.
Lynch, David
Rumsey, Christopher
TI Uterine Arteriovenous Malformation, Images, and Management
SO MILITARY MEDICINE
LA English
DT Article
ID UTERUS
AB Background: Uterine arteriovenous malformation (AVM) is an infrequently described cause of severe genital tract bleeding. This is an important diagnostic consideration as therapeutic options differ significantly from those utilized with alternate etiologies of genital tract bleeding. Case: A 30-year-old multiparous female presented initially with vaginal bleeding, and subsequently with intra-abdominal hemorrhage. She was diagnosed with uterine AVM, and was managed with uterine artery embolization followed by eventual hysterectomy. Conclusion: AVMs, both congenital and acquired, are diagnosed utilizing a range of radiographic tools. Management modalities include embolization and hysterectomy. Our patient presented uniquely with intra-abdominal hemorrhage. Previously managed with uterine artery embolization, hysterectomy became necessary because of her clinical presentation.
C1 [Ore, Maj Robert M.] David Grant Med Ctr, Womens Hlth Clin, Travis AFB, CA 94535 USA.
[Lynch, David] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
[Rumsey, Christopher] OB GYN, Ft Drum, Watertown, NY 13601 USA.
RP Ore, MRM (reprint author), David Grant Med Ctr, Womens Hlth Clin, 101 Bodin Circle, Travis AFB, CA 94535 USA.
NR 7
TC 0
Z9 0
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD JAN
PY 2015
VL 180
IS 1
BP E177
EP E180
DI 10.7205/MILMED-D-14-00145
PG 4
WC Medicine, General & Internal
SC General & Internal Medicine
GA CA7MM
UT WOS:000349101400015
ER
PT J
AU Pritchett, TM
Ferry, MJ
Mott, AG
Shensky, W
Haley, JE
Liu, R
Sun, WF
AF Pritchett, Timothy M.
Ferry, Michael J.
Mott, Andrew G.
Shensky, William, III
Haley, Joy E.
Liu, Rui
Sun, Wenfang
TI Long-lifetime reverse saturable absorption in a bipyridyl platinum(II)
complex bearing naphthalimidylethynyl-substituted fluorenylacetylide
ligands
SO OPTICAL MATERIALS
LA English
DT Article
DE Z scan; Reverse saturable absorption
ID EXCITED-STATE ABSORPTION; DIIMINE BIS(ACETYLIDE) COMPLEXES; TOP-HAT
BEAMS; NONLINEAR ABSORPTION; ACETYLIDE COMPLEXES; PHOTOPHYSICS;
PHOSPHORESCENCE; LUMINESCENCE; OXYGEN
AB By fitting femtosecond transient difference absorption time series at multiple wavelengths, the singlet excited-state lifetime of a particular platinum(II) 2,2'-bipyridyl complex bearing naphthalimidylethynyl-substituted fluorenyl-acetylide ligands was determined to be 83.5 +/- 39 ps in toluene solution. A triplet quantum yield of 0.06 was measured using relative actinometry. Excited-state absorption cross sections of 5.6 x 10(-17) cm(2) (singlet) and 7.8 x 10(-16) cm(2) (triplet) at 532 nm were obtained by using a five-level dynamic model to fit open-aperture Z scans at picosecond and nanosecond pulse widths and a variety of pulse energies. Most significantly, fits of nanosecond transient difference absorption decay data yield a value of 16.3 ps for the triplet excited-state lifetime of the complex in deoxygenated toluene solution, longer by a factor of almost 20 than the lifetime of the analogous complex with benzothiazolyl-substituted ligands. Published by Elsevier B.V.
C1 [Pritchett, Timothy M.; Ferry, Michael J.; Mott, Andrew G.; Shensky, William, III] US Army, Res Lab, Attn RDRL SEE L, Adelphi, MD 20783 USA.
[Haley, Joy E.] Air Force Res Lab, Mat & Mfg Directorate, Wright Patterson AFB, OH 45433 USA.
[Liu, Rui; Sun, Wenfang] N Dakota State Univ, Dept Chem & Biochem, Fargo, ND 58108 USA.
RP Pritchett, TM (reprint author), US Army, Res Lab, Attn RDRL SEE L, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM timothy.m.pritchett.civ@mail.mil
NR 26
TC 6
Z9 6
U1 3
U2 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0925-3467
EI 1873-1252
J9 OPT MATER
JI Opt. Mater.
PD JAN
PY 2015
VL 39
BP 195
EP 198
DI 10.1016/j.optmat.2014.11.025
PG 4
WC Materials Science, Multidisciplinary; Optics
SC Materials Science; Optics
GA CA2OQ
UT WOS:000348747900033
ER
PT S
AU Gunnarsson, CA
Love, B
Moy, P
Weerasooriya, T
AF Gunnarsson, C. Allan
Love, Bryan
Moy, Paul
Weerasooriya, Tusit
BE Jin, H
Sciammarella, C
Yoshida, S
Lamberti, L
TI Tensile Response and the Associated Post: Yield Heating of Polycarbonate
SO ADVANCEMENT OF OPTICAL METHODS IN EXPERIMENTAL MECHANICS, VOL 3
SE Conference Proceedings of the Society for Experimental Mechanics Series
LA English
DT Proceedings Paper
CT SEM Annual Conference and Exposition on Experimental and Applied
Mechanics
CY JUN 02-05, 2014
CL Greenville, SC
SP Soc Expt Mech
DE DIC; Thermal response; Polycarbonate; Strain rate effect; Post yield
behavior
AB It is well known that amorphous polymers, such as polycarbonate (PC), will exhibit adiabatic heating due to the large plastic work that occurs when undergoing significant plastic deformation. However the extent of adiabatic heating has not been investigated with respect to strain rate, with full-field temperature measurements performed on the specimen during deformation. In this study, ASTM tensile dog bone PC specimens were used to investigate the rate-dependent mechanical response from quasi-static to intermediate (similar to 10 s(-1)) strain rates using a traditional servo-hydraulic load frame. To determine the variations in yield and post-yield response at different locations of the gage area of the specimen, digital image correlation was used to measure the full-field surface strains. In addition, an InSb thermal camera was used concurrently to measure the full-field temperature distribution in the gage area during the deformation. The material experienced non-uniform heating as high as 50-70 degrees C, and showed significant rate sensitive mechanical response. In this paper, the experimental techniques and results are discussed.
C1 [Gunnarsson, C. Allan; Love, Bryan; Moy, Paul; Weerasooriya, Tusit] Army Res Lab, Adelphi, MD 20783 USA.
RP Gunnarsson, CA (reprint author), Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM carey.a.gunnarsson.civ@mail.mil
NR 6
TC 0
Z9 0
U1 1
U2 2
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
SN 2191-5644
BN 978-3-319-06985-2
J9 C PROC SOC EXP MECH
PY 2015
BP 399
EP 401
DI 10.1007/978-3-319-06986-9_48
PG 3
WC Optics; Physics, Applied
SC Optics; Physics
GA BB8XF
UT WOS:000347773500048
ER
PT J
AU Wolf, TJ
Chuh, A
Floyd, T
McInnis, K
Williams, E
AF Wolf, Timothy J.
Chuh, Adrianna
Floyd, Tracy
McInnis, Karen
Williams, Elizabeth
TI Effectiveness of Occupation-Based Interventions to Improve Areas of
Occupation and Social Participation After Stroke: An Evidence-Based
Review
SO AMERICAN JOURNAL OF OCCUPATIONAL THERAPY
LA English
DT Review
DE activities of daily living; evaluation studies as topic; human
activities; social participation; stroke
ID RANDOMIZED CONTROLLED-TRIAL; SELF-CARE INTERVENTION; REHABILITATION
PROGRAM; THERAPY INTERVENTION; CLINICAL-TRIAL; COMMUNITY; EDUCATION;
SKILLS; PERFORMANCE; SURVIVORS
AB This evidence-based review examined the evidence supporting the use of occupation-based interventions to improve areas of occupation and social participation poststroke. A total of 39 studies met the inclusion criteria and were critically evaluated. Most of the literature targeted activity of daily living (ADL)-based interventions and collectively provided strong evidence for the use of occupation-based interventions to improve ADL performance. The evidence related to instrumental ADLs was much more disparate, with limited evidence to support the use of virtual reality interventions and emerging evidence to support driver education programs to improve occupational performance poststroke. Only 6 studies addressed leisure, social participation, or rest and sleep, with sufficient evidence to support only leisure-based interventions. The implications of this review for research, education, and practice in occupational therapy are also discussed.
C1 [Wolf, Timothy J.; Chuh, Adrianna; McInnis, Karen; Williams, Elizabeth] Washington Univ, Sch Med, Program Occupat Therapy, St Louis, MO 63130 USA.
[Wolf, Timothy J.] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA.
[Floyd, Tracy] US Army, Ft Belvoir, VA USA.
RP Wolf, TJ (reprint author), Washington Univ, Sch Med, Program Occupat Therapy, St Louis, MO 63130 USA.
EM wolft@wustl.edu
OI Wolf, Timothy/0000-0003-3607-9454
FU National Center for Medical Rehabilitation Research [K23HD073190]
FX We thank Deborah Lieberman and Marian Arbesman for their support and
guidance in completing this evidence-based review. Timothy Wolf received
salary support to complete this study from the National Center for
Medical Rehabilitation Research (Award No. K23HD073190). The content is
solely the responsibility of the authors and does not necessarily
represent the official views of the National Institutes of Health.
NR 49
TC 2
Z9 2
U1 11
U2 22
PU AMER OCCUPATIONAL THERAPY ASSOC, INC
PI BETHESDA
PA 4720 MONTGOMERY LANE, BETHESDA, MD 20814-3425 USA
SN 0272-9490
EI 1943-7676
J9 AM J OCCUP THER
JI Am. J. Occup. Ther.
PD JAN-FEB
PY 2015
VL 69
IS 1
BP 58
EP 68
DI 10.5014/ajot.2015.012195
PG 11
WC Rehabilitation
SC Rehabilitation
GA AZ8TT
UT WOS:000348488100009
ER
PT J
AU Ewers, EC
Dennison, DH
Stagliano, DR
AF Ewers, Evan C.
Dennison, David H.
Stagliano, David R.
TI A Unique Case of Adolescent Neuroborreliosis Presenting With Multiple
Cranial Neuritis and Cochlear Inflammation on Magnetic Resonance Imaging
SO PEDIATRIC NEUROLOGY
LA English
DT Article
DE Lyme disease; neuroborreliosis; hearing loss; Bannwarth syndrome;
cochleitis
ID LYME-DISEASE; HEARING-LOSS; MANIFESTATIONS; MENINGITIS
AB BACKGROUND: Lyme disease is the most common vector-borne disease in the United States and is caused by infection with the spirochete Borrelia burgdorferi. In children, neuroborreliosis usually presents as peripheral facial nerve palsy and lymphocytic meningitis and only rarely is associated with cranial polyneuritis. PATIENT DESCRIPTION: We present a 15-year-old with tinnitus, hearing loss, and facial nerve palsy in the setting of acute, severe right arm pain and a several week history of malaise and headache. Lumbar puncture was notable for lymphocytic pleocytosis. Serologic testing demonstrated positive Lyme antibody and a positive immunoglobulin M Western blot. Immunofluorescent assay of cerebrospinal fluid was also positive for anti-Lyme immunoglobulin M. Audiologic testing revealed mixed, right-sided hearing loss. Neuroimaging demonstrated cranial polyneuritis and right-sided cochlear inflammation. The patient was treated with parenteral ceftriaxone with resolution of his symptoms at close follow-up. DISCUSSION: Neuroborreliosis with radiculopathy, lymphocytic meningitis, and cranial polyneuritis is a rare presentation of pediatric Lyme disease. Additionally, cochlear inflammation along with cranial nerve VIII inflammation may contribute to hearing loss in patients with neuroborreliosis.
C1 [Ewers, Evan C.] Tripler Army Med Ctr, Dept Med, Honolulu, HI 96859 USA.
[Dennison, David H.] Walter Reed Natl Mil Med Ctr, Dept Neurol, Bethesda, MD USA.
[Stagliano, David R.] Walter Reed Natl Mil Med Ctr, Dept Pediat, Bethesda, MD USA.
RP Ewers, EC (reprint author), Tripler Army Med Ctr, Dept Med, Honolulu, HI 96859 USA.
EM evan.c.ewers.mil@mail.mil
OI Ewers, Evan/0000-0002-1384-9973
NR 10
TC 1
Z9 1
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0887-8994
EI 1873-5150
J9 PEDIATR NEUROL
JI Pediatr. Neurol.
PD JAN
PY 2015
VL 52
IS 1
BP 107
EP 109
DI 10.1016/j.pediatrneurol.2014.10.009
PG 3
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA AZ7QA
UT WOS:000348411800016
PM 25459362
ER
PT J
AU Zhu, SH
Reuther, J
Liu, J
Crocker, FH
Indest, KJ
Eltis, LD
Mohn, WW
AF Zhu, Song-Hua
Reuther, Jens
Liu, Jie
Crocker, Fiona H.
Indest, Karl J.
Eltis, Lindsay D.
Mohn, William W.
TI The essential role of nitrogen limitation in expression of xplA and
degradation of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) in Gordonia
sp strain KTR9
SO APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
LA English
DT Article
DE RDX degradation; Metabolism; Gene expression/regulation; xplA; GlnR;
Bacteria
ID REGULATOR GLNR; RHODOCOCCUS; BIODEGRADATION; GENE; BACTERIA; DN22;
CYTOCHROME-P-450; ASSIMILATION; METABOLISM; PLASMID
AB Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) is a widely used explosive and a major soil and groundwater contaminant. Organisms such as Gordonia sp. KTR9, capable of degrading RDX and using it as an N source, may prove useful for bioremediation of contaminated sites. XplA is a cytochrome P450 monooxygenase responsible for RDX degradation. Expression of xplA in KTR9 was not induced by RDX but was strongly induced (50-fold) during N-limited growth. When glnR, encoding a regulatory protein affecting N assimilation in diverse Actinobacteria, was deleted from KTR9, the bacterium lost the ability to use nitrate, nitrite, and RDX as N sources. Deletion of glnR also abolished the inhibition of xplA expression by nitrite. Our results confirm the essential role of GlnR in regulating assimilation of nitrite, but there was no evidence for a direct role of GlnR in regulating XplA expression. Rather, the general availability of nitrogen repressed XplA expression. We conclude that the inability of the glnR mutant to use RDX as an N source was due to its inability to assimilate nitrite, an intermediate in the assimilation of nitrogen from RDX. Regulation of XplA does not seem adaptive for KTR9, but it is important for RDX bioremediation with KTR9 or similar bacteria.
C1 [Zhu, Song-Hua; Reuther, Jens; Liu, Jie; Eltis, Lindsay D.; Mohn, William W.] Univ British Columbia, Dept Microbiol & Immunol, Inst Life Sci, Vancouver, BC V5Z 1M9, Canada.
[Crocker, Fiona H.; Indest, Karl J.] US Army Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS USA.
RP Mohn, WW (reprint author), Univ British Columbia, Dept Microbiol & Immunol, Inst Life Sci, Vancouver, BC V5Z 1M9, Canada.
EM wmohn@mail.ubc.ca
RI Eltis, Lindsay/J-8272-2015
OI Eltis, Lindsay/0000-0002-6774-8158
FU Genome BC; Strategic Environmental Research and Development Program
[ER-1609]; US Army Corps of Engineers Environmental Quality Program
FX This research was funded in part through grants from Genome BC, the
Strategic Environmental Research and Development Program (Project
ER-1609), and the US Army Corps of Engineers Environmental Quality
Program. Views, opinions, and/or findings contained herein are those of
the authors and should not be construed as an official Department of the
Army position or decision unless so designated by other official
documentation. We thank Christine Florizone for guidance in chemical
analyses.
NR 33
TC 2
Z9 2
U1 2
U2 21
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0175-7598
EI 1432-0614
J9 APPL MICROBIOL BIOT
JI Appl. Microbiol. Biotechnol.
PD JAN
PY 2015
VL 99
IS 1
SI SI
BP 459
EP 467
DI 10.1007/s00253-014-6013-z
PG 9
WC Biotechnology & Applied Microbiology
SC Biotechnology & Applied Microbiology
GA AY6OK
UT WOS:000347685300041
PM 25142696
ER
PT J
AU O'Reilly, DJ
Morrison, JJ
Apodoca-Morrison, AN
Jansen, JO
Midwinter, MJ
AF O'Reilly, D. J.
Morrison, J. J.
Apodoca-Morrison, A. N.
Jansen, J. O.
Midwinter, M. J.
TI Prehospital Blood Transfusion in the En Route Management of Severe
Combat Trauma: A Matched Cohort Study
SO BRITISH JOURNAL OF SURGERY
LA English
DT Meeting Abstract
CT International Surgical Congress of the
Association-of-Surgeons-of-Great-Britain-and-Ireland (ASGBI)
CY APR 30-MAY 02, 2014
CL Harrogate, ENGLAND
SP Assoc Surg Great Britain & Ireland
C1 [O'Reilly, D. J.; Morrison, J. J.; Jansen, J. O.; Midwinter, M. J.] Royal Ctr Def Med, Birmingham, W Midlands, England.
[Apodoca-Morrison, A. N.] US Army Inst Surg Res, San Antonio, TX USA.
RI Midwinter, Mark/P-6264-2015
OI Midwinter, Mark/0000-0003-1836-7137
NR 0
TC 0
Z9 0
U1 1
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1323
EI 1365-2168
J9 BRIT J SURG
JI Br. J. Surg.
PD JAN
PY 2015
VL 102
SU 1
MA 0187
BP 114
EP 114
PG 1
WC Surgery
SC Surgery
GA AW8DA
UT WOS:000346489700343
ER
PT J
AU Fries, C
Spencer, J
Villamaria, C
Rickard, R
Davis, M
AF Fries, C.
Spencer, J.
Villamaria, C.
Rickard, R.
Davis, M.
TI Hyperbaric Warm Perfusion Maintains Tissue Composites Ex-Vivo Beyond
Normal Limits of Cold Ischemia
SO BRITISH JOURNAL OF SURGERY
LA English
DT Meeting Abstract
CT International Surgical Congress of the
Association-of-Surgeons-of-Great-Britain-and-Ireland (ASGBI)
CY APR 30-MAY 02, 2014
CL Harrogate, ENGLAND
SP Assoc Surg Great Britain & Ireland
C1 [Fries, C.; Spencer, J.; Villamaria, C.; Davis, M.] US Army Inst Surg Res, San Antonio, TX USA.
[Rickard, R.] Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1323
EI 1365-2168
J9 BRIT J SURG
JI Br. J. Surg.
PD JAN
PY 2015
VL 102
SU 1
MA 0816
BP 116
EP 117
PG 2
WC Surgery
SC Surgery
GA AW8DA
UT WOS:000346489700353
ER
PT J
AU Fries, C
Spencer, J
Villamaria, C
Rickard, R
Davis, M
AF Fries, C.
Spencer, J.
Villamaria, C.
Rickard, R.
Davis, M.
TI Hydrogen Sulphide Mitigates Ischemia Reperfusion Injury in Vascularised
Composite Allotransplantation and Delays the Onset of Acute Rejection
SO BRITISH JOURNAL OF SURGERY
LA English
DT Meeting Abstract
CT International Surgical Congress of the
Association-of-Surgeons-of-Great-Britain-and-Ireland (ASGBI)
CY APR 30-MAY 02, 2014
CL Harrogate, ENGLAND
SP Assoc Surg Great Britain & Ireland
C1 [Fries, C.; Spencer, J.; Villamaria, C.; Davis, M.] US Army Inst Surg Res, San Antonio, TX USA.
[Rickard, R.] Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1323
EI 1365-2168
J9 BRIT J SURG
JI Br. J. Surg.
PD JAN
PY 2015
VL 102
SU 1
MA 0817
BP 117
EP 117
PG 1
WC Surgery
SC Surgery
GA AW8DA
UT WOS:000346489700354
ER
PT J
AU Ledford, CJW
Seehusen, DA
Chessman, AW
Shokar, NK
AF Ledford, Christy J. W.
Seehusen, Dean A.
Chessman, Alexander W.
Shokar, Navkiran K.
TI How We Teach US Medical Students to Negotiate Uncertainty in Clinical
Care: A CERA Study
SO FAMILY MEDICINE
LA English
DT Article
ID DECISION-MAKING; FOLLOW-UP; EDUCATION; MAMMOGRAPHY; PROGNOSIS; ETHICS;
FACE
AB BACKGROUND AND OBJECTIVES: The patient relies on the physician to help negotiate medical evidence, particularly when experts disagree. For shared decision making to be most effective, the physician must disclose personal uncertainty. This study proposes to describe how uncertainty management is intentionally and systematically taught to medical students.
METHODS: A cross-sectional survey was administered to all family medicine clerkship directors (FM CDs) at US allopathic medical schools. Items evaluated the teaching of uncertainty in two domains (instruction and modeling).
RESULTS: Eighty-six of 134 (64.18%) FM CDs surveyed completed the survey. Overall, an average of 2.6 hours was devoted to learning about clinical guidelines. The teaching objective addressed least by this sample was discussing uncertainty with the patient. Most curricula do not engage the medical students in how to discuss uncertainty with patients. Hypothesis testing revealed that the clerkship's general attitude toward the importance of teaching students how to deal with competing medical evidence is associated with both instruction and modeling behavior.
DISCUSSION: FM CDs demonstrate a positive attitude toward teaching students how to deal with competing evidence. Clerkships do provide students with the opportunity to see faculty engage in uncertainty discussions with patients. Opportunities exist to improve medical student competence in discussing uncertainty in a productive manner. Clerkship directors influence curriculum development and implementation but through their attitude also construct a culture that can be positively aligned with teaching medical students how to negotiate uncertainty in clinical care.
C1 [Ledford, Christy J. W.] Uniformed Serv Univ Hlth Sci, Dept Family Med, Bethesda, MD 20814 USA.
[Seehusen, Dean A.] Eisenhower Army Med Ctr, Dept Family & Community Med, Ft Gordon, GA USA.
[Chessman, Alexander W.] Med Univ S Carolina, Dept Family Med, Charleston, SC USA.
[Shokar, Navkiran K.] Texas Tech Univ, Hlth Sci Ctr, Dept Family & Community Med, El Paso, TX USA.
RP Ledford, CJW (reprint author), Uniformed Serv Univ Hlth Sci, Dept Family Med, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
EM christian.ledford@usuhs.edu
NR 35
TC 1
Z9 1
U1 0
U2 1
PU SOC TEACHERS FAMILY MEDICINE
PI LEAWOOD
PA 11400 TOMAHAWK CREEK PARKWAY, STE 540, LEAWOOD, KS 66207 USA
SN 0742-3225
EI 1938-3800
J9 FAM MED
JI Fam. Med.
PD JAN
PY 2015
VL 47
IS 1
BP 31
EP 36
PG 6
WC Primary Health Care; Medicine, General & Internal
SC General & Internal Medicine
GA AZ2ZG
UT WOS:000348097100005
PM 25646875
ER
PT J
AU Richard, R
Jones, JA
Parshley, P
AF Richard, Reg
Jones, John A.
Parshley, Philip
TI Hierarchical Decomposition of Burn Body Diagram Based on Cutaneous
Functional Units and Its Utility
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
ID DONOR-SITE WOUNDS; SURFACE-AREA; HAND; CONTRACTURE; VICTIMS; INJURY;
OBESE; NINES; LIFE; RULE
AB A burn body diagram (BBD) is a common feature used in the delivery of burn care for estimating the TBSA burn as well as calculating fluid resuscitation and nutritional requirements, wound healing, and rehabilitation intervention. However, little change has occurred for over seven decades in the configuration of the BBD. The purpose of this project was to develop a computerized model using hierarchical decomposition (HD) to more precisely determine the percentage burn within a BBD based on cutaneous functional units (CFUs). HD is a process by which a system is degraded into smaller parts that are more precise in their use. CFUs were previously identified fields of the skin involved in the range of motion. A standard Lund/Browder (LB) BBD template was used as the starting point to apply the CFU segments. LB body divisions were parceled down into smaller body area divisions through a HD process based on the CFU concept. A numerical pattern schema was used to label the various segments in a cephalo/caudal, anterior/posterior, medial/lateral manner. Hand/fingers were divided based on anatomical landmarks and known cutaneokinematic function. The face was considered using aesthetic units. Computer code was written to apply the numeric hierarchical schema to CFUs and applied within the context of the surface area graphic evaluation BBD program. Each segmented CFU was coded to express 100% of itself. The CFU/HD method refined the standard LB diagram from 13 body segments and 33 subdivisions into 182 isolated CFUs. Associated CFUs were reconstituted into 219 various surface area combinations totaling 401 possible surface segments. The CFU/HD schema of the body surface mapping is applicable to measuring and calculating percent wound healing in a more precise manner. It eliminates subjective assessment of the percentage wound healing and the need for additional devices such as planimetry. The development of CFU/HD body mapping schema has rendered a technologically advanced system to depict body burns. The process has led to a more precise estimation of the segmented body areas while preserving the overall TBSA information. Clinical application to date has demonstrated its worthwhile utility.
C1 [Richard, Reg; Jones, John A.] US Army, Inst Surg Res, Burn Ctr, Jbsa Ft Sam Houston, TX 78234 USA.
[Parshley, Philip] SAGE Diagram LLC, Portland, OR USA.
RP Richard, R (reprint author), Inst Surg Res, 3698 Chambers Pass,STE B, Jbsa Ft Sam Houston, TX 78234 USA.
FU Department of Defense [W81XWH-08-1-0683]
FX This study was funded by the Department of Defense W81XWH-08-1-0683.
NR 40
TC 2
Z9 2
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD JAN-FEB
PY 2015
VL 36
IS 1
BP 33
EP 43
DI 10.1097/BCR.0000000000000150
PG 11
WC Emergency Medicine; Dermatology; Surgery
SC Emergency Medicine; Dermatology; Surgery
GA AY3AG
UT WOS:000347456400008
PM 25162946
ER
PT J
AU Reiter, MJ
Bui-Mansfield, LT
O'Brien, SD
Tubb, CC
AF Reiter, Michael J.
Bui-Mansfield, Liem T.
O'Brien, Seth D.
Tubb, Creighton C.
TI Subtrochanteric Femur Fractures: Review of the Complete Pathologic
Spectrum With Emphasis on Distinguishing Imaging Features
SO JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY
LA English
DT Review
DE subtrochanteric femur fracture; bisphosphonate-associated fracture;
pathologic fracture; Paget disease; subsidence
ID LONGITUDINAL STRESS-FRACTURES; ATYPICAL FEMORAL FRACTURES;
BISPHOSPHONATE THERAPY; HIP-ARTHROPLASTY; PAGETS-DISEASE; BONE;
COMPLICATIONS; NECK; TOMOGRAPHY; APPEARANCE
AB Subtrochanteric femur fractures result from a variety of mechanisms of injury and underlying pathologies. Radiologists can play a pivotal role by differentiating the etiology of a subtrochanteric femur fracture, which assists the orthopedic surgeon in choosing the correct method of treatment. To provide this valuable service, onemust be familiar with the characteristic radiologic features of the numerous causative etiologies, ranging from Paget disease to underlying bone lesions to iatrogenic fractures.
C1 [Reiter, Michael J.; Bui-Mansfield, Liem T.; O'Brien, Seth D.] Brooke Army Med Ctr, Dept Radiol, San Antonio, TX 78234 USA.
[Reiter, Michael J.; Bui-Mansfield, Liem T.; O'Brien, Seth D.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Tubb, Creighton C.] Brooke Army Med Ctr, Dept Orthoped Surg, San Antonio, TX 78234 USA.
RP Reiter, MJ (reprint author), Brooke Army Med Ctr, Dept Radiol, 3551 Roger Brooke Dr, San Antonio, TX 78234 USA.
EM mikereiter13@yahoo.com
NR 55
TC 1
Z9 1
U1 3
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0363-8715
EI 1532-3145
J9 J COMPUT ASSIST TOMO
JI J. Comput. Assist. Tomogr.
PD JAN-FEB
PY 2015
VL 39
IS 1
BP 47
EP 56
PG 10
WC Radiology, Nuclear Medicine & Medical Imaging
SC Radiology, Nuclear Medicine & Medical Imaging
GA AZ4IG
UT WOS:000348184200009
PM 25354094
ER
PT J
AU Johnson, BW
Madson, AQ
Bong-Thakur, S
Tucker, D
Hale, RG
Chan, RK
AF Johnson, Benjamin W.
Madson, Andrew Q.
Bong-Thakur, Sarah
Tucker, David
Hale, Robert G.
Chan, Rodney K.
TI Combat-Related Facial Burns: Analysis of Strategic Pitfalls
SO JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
LA English
DT Article
ID OPERATION IRAQI FREEDOM; US MILITARY OPERATIONS; ENDURING FREEDOM;
CRANIOMAXILLOFACIAL INJURIES; EARLY EXCISION; NECK; FACE; WOUNDS; WAR
AB Purpose: Burns constitute approximately 10% of all combat-related injuries to the head and neck region. We postulated that the combat environment presents unique challenges not commonly encountered among civilian injuries. The purpose of the present study was to determine the features commonly seen among combat facial burns that will result in therapeutic challenges and might contribute to undesired outcomes.
Materials and Methods: The present study was a retrospective study performed using a query of the Burn Registry at the US Army Institute of Surgical Research Burn Center for all active duty facial burn admissions from October 2001 to February 2011. The demographic data, total body surface area of the burn, facial region body surface area involvement, and dates of injury, first operation, and first facial operation were tabulated and compared. A subset analysis of severe facial burns, defined by a greater than 7% facial region body surface area, was performed with a thorough medical record review to determine the presence of associated injuries.
Results: Of all the military burn injuries, 67.1% (n = 558) involved the face. Of these, 81.3% (n = 454) were combat related. The combat facial burns had a mean total body surface area of 21.4% and a mean facial region body surface area of 3.2%. The interval from the date of the injury to the first operative encounter was 6.6 +/- 0.8 days and was 19.8 +/- 2.0 days to the first facial operation. A subset analysis of the severe facial burns revealed that the first facial operation and the definitive coverage operation was performed at 13.45 +/- 2.6 days and 31.9 +/- 4.1 days after the injury, respectively. The mortality rate for this subset of patients was 32% (n = 10), with a high rate of associated inhalational injuries (61%, n = 19), limb amputations (29%, n = 9), and facial allograft usage (48%, n = 15) and a mean facial autograft thickness of 10.5/1,000th in.
Conclusions: Combat-related facial burns present multiple challenges, which can contribute to suboptimal long-term outcomes. These challenges include prolonged transport to the burn center, delayed initial intervention and definitive coverage, and a lack of available high-quality color-matched donor skin. These gaps all highlight the need for novel anti-inflammatory and skin replacement strategies to more adequately address these unique combat-related obstacles. (C) 2015 American Association of Oral and Maxillofacial Surgeons
C1 [Johnson, Benjamin W.] San Antonio Mil Med Ctr, Dept Oral & Maxillofacial Surg, Ft Sam Houston, TX 78234 USA.
[Madson, Andrew Q.] US Army, Inst Surg Res, Burn Ctr, Ft Sam Houston, TX 78234 USA.
[Madson, Andrew Q.] US Army, Inst Surg Res, Clin Div, Ft Sam Houston, TX 78234 USA.
[Bong-Thakur, Sarah; Tucker, David; Hale, Robert G.; Chan, Rodney K.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
RP Chan, RK (reprint author), San Antonio Mil Med Ctr, Dept Oral & Maxillofacial Surg, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM rodney.k.chan.ctr@mail.mil
NR 25
TC 2
Z9 2
U1 0
U2 0
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0278-2391
EI 1531-5053
J9 J ORAL MAXIL SURG
JI J. Oral Maxillofac. Surg.
PD JAN
PY 2015
VL 73
IS 1
BP 106
EP 111
DI 10.1016/j.joms.2014.08.022
PG 6
WC Dentistry, Oral Surgery & Medicine
SC Dentistry, Oral Surgery & Medicine
GA AY6ZZ
UT WOS:000347712300018
PM 25511961
ER
PT J
AU Islam, MM
Ostadhossein, A
Borodin, O
Yeates, AT
Tipton, WW
Hennig, RG
Kumar, N
van Duin, ACT
AF Islam, Md Mahbubul
Ostadhossein, Alireza
Borodin, Oleg
Yeates, A. Todd
Tipton, William W.
Hennig, Richard G.
Kumar, Nitin
van Duin, Adri C. T.
TI ReaxFF molecular dynamics simulations on lithiated sulfur cathode
materials
SO PHYSICAL CHEMISTRY CHEMICAL PHYSICS
LA English
DT Article
ID REACTIVE FORCE-FIELD; RECHARGEABLE LITHIUM BATTERIES; HIGH SPECIFIC
ENERGY; LI-S BATTERIES; SOLID-ELECTROLYTE; ION BATTERIES; AB-INITIO;
ENCAPSULATED SULFUR; SILICON ELECTRODES; LIQUID ELECTROLYTE
AB Sulfur is a very promising cathode material for rechargeable energy storage devices. However, sulfur cathodes undergo a noticeable volume variation upon cycling, which induces mechanical stress. In spite of intensive investigation of the electrochemical behavior of the lithiated sulfur compounds, their mechanical properties are not very well understood. In order to fill this gap, we developed a ReaxFF interatomic potential to describe Li-S interactions and performed molecular dynamics (MD) simulations to study the structural, mechanical, and kinetic behavior of the amorphous lithiated sulfur (a-LixS) compounds. We examined the effect of lithiation on material properties such as ultimate strength, yield strength, and Young's modulus. Our results suggest that with increasing lithium content, the strength of lithiated sulfur compounds improves, although this increment is not linear with lithiation. The diffusion coefficients of both lithium and sulfur were computed for the a-LixS system at various stages of Li-loading. A grand canonical Monte Carlo (GCMC) scheme was used to calculate the open circuit voltage profile during cell discharge. The Li-S binary phase diagram was constructed using genetic algorithm based tools. Overall, these simulation results provide insight into the behavior of sulfur based cathode materials that are needed for developing lithium-sulfur batteries.
C1 [Islam, Md Mahbubul; van Duin, Adri C. T.] Penn State Univ, Dept Mech & Nucl Engn, University Pk, PA 16802 USA.
[Ostadhossein, Alireza] Penn State Univ, Dept Engn Sci & Mech, University Pk, PA 16802 USA.
[Borodin, Oleg] US Army, Res Lab, Electrochem Branch, Adelphi, MD 20783 USA.
[Yeates, A. Todd] US Air Force, Res Lab, Mat & Mfg Directorate, AFRL RXBN, Wright Patterson AFB, OH 45433 USA.
[Tipton, William W.; Hennig, Richard G.] Cornell Univ, Dept Mat Sci & Engn, Ithaca, NY 14853 USA.
[Kumar, Nitin] Sandia Natl Labs, Albuquerque, NM 87185 USA.
RP van Duin, ACT (reprint author), Penn State Univ, Dept Mech & Nucl Engn, University Pk, PA 16802 USA.
EM acv13@psu.edu
RI Islam, Md Mahbubul/O-9375-2015; Borodin, Oleg/B-6855-2012; Hennig,
Richard/A-2978-2008
OI Islam, Md Mahbubul/0000-0003-4584-2204; Borodin,
Oleg/0000-0002-9428-5291; Hennig, Richard/0000-0003-4933-7686
FU US Army Research Laboratory through the Collaborative Research Alliance
(CRA) for Multi Scale Multidisciplinary Modeling of Electronic Materials
(MSME); DoD High Performance Computing (HPC) Productivity Enhancement,
Technology Transfer, and Training (PETTT) Program [PP-CCM-KY03-005-P3]
FX This work was supported by the grant from the US Army Research
Laboratory through the Collaborative Research Alliance (CRA) for Multi
Scale Multidisciplinary Modeling of Electronic Materials (MSME) and DoD
High Performance Computing (HPC) Productivity Enhancement, Technology
Transfer, and Training (PETTT) Program contract number
PP-CCM-KY03-005-P3.
NR 84
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U1 8
U2 106
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 1463-9076
EI 1463-9084
J9 PHYS CHEM CHEM PHYS
JI Phys. Chem. Chem. Phys.
PY 2015
VL 17
IS 5
BP 3383
EP 3393
DI 10.1039/c4cp04532g
PG 11
WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical
SC Chemistry; Physics
GA AZ4OW
UT WOS:000348203200047
PM 25529209
ER
PT J
AU Morasch, KC
Aaron, CL
Moon, JE
Gordon, RK
AF Morasch, Katherine C.
Aaron, Christopher L.
Moon, James E.
Gordon, Richard K.
TI Physiological and neurobehavioral effects of cholinesterase inhibition
in healthy adults
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Organophosphate prophylaxis; Acetylcholinesterase inhibition;
Neurobehavioral performance; Huperzine A; Galantamine; Donepezil
ID SLEEP-DEPRIVATION; HUPERZINE-A; ALZHEIMERS-DISEASE; EPISODIC MEMORY;
YOUNG-ADULTS; PERFORMANCE; DONEPEZIL; ACETYLCHOLINESTERASE;
PYRIDOSTIGMINE; VOLUNTEERS
AB Introduction: Based on common pharmacodynamic mechanisms, recent efforts to develop second generation alternatives for organophosphate (OP) prophylaxis have expanded to include cholinesterase (ChE) inhibiting compounds traditionally approved for use in the treatment of Alzheimer's disease (AD). The primary purpose of this study was to determine the extent to which low-dose huperzine A, galantamine, or donepezil selectively inhibited acetylcholinesterase (AChE) versus butyrylcholinesterase (BChE) activity in healthy adults and whether such inhibition impacted neurobehavioral performance.
Methods: In addition to hourly red blood cell cholinesterase sampling, neurobehavioral function was assessed before and after a single oral dose of huperzine A (100 or 200 Kg), galantamine (4 or 8 mg), donepezil (2.5 or 5 mg), or placebo (n = 12 subjects per drug/dose).
Results: Compared to placebo, both dosages of huperzine A and galantamine inhibited circulating AChE but not BChE. With the exception of huperzine A (200 jig), which maintained declarative recall performance across sessions, compounds did not improve neurobehavioral performance. Some aspects of neurobehavioral performance correlated with AChE activity, although associations may have reflected time of day effects.
Discussion: Although huperzine A and galantamine significantly inhibited AChE (and likely increased central acetylcholine levels), neither compound improved neurobehavioral performance. The latter was likely due to ceiling effects in this young, healthy test population. Under conditions of reduced cholinergic activity (e.g., Alzheimer's disease), AChE inhibition (and corresponding maintenance of cholinergic tone) could potentially maintain/augment some aspects of neurobehavioral function. Published by Elsevier Inc.
C1 [Morasch, Katherine C.; Moon, James E.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
[Aaron, Christopher L.] Ft Belvoir Community Hosp, Ft Belvoir, VA 22060 USA.
RP Morasch, KC (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM kmorasch@gmail.com
RI Moon, James/B-6810-2011
OI Moon, James/0000-0002-9274-4554
FU DTRA project [CBM.NEURO.01.10 WR020]
FX The authors would like to acknowledge Ms. Ruthie Ratcliffe and Ms.
Rachel Newman for data collection, Ms. Linda Harvey for conducting the
whole blood cholinesterase assays, and Nancy Wesensten, Ph.D. for her
substantial contributions to this work. We thank Franklin Volvovitz,
Ph.D., of Biomedisyn Corporation, for providing huperzine A. This
project was supported by DTRA project # CBM.NEURO.01.10 WR020.
NR 32
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PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD JAN
PY 2015
VL 138
BP 165
EP 172
DI 10.1016/j.physbeh.2014.09.010
PG 8
WC Psychology, Biological; Behavioral Sciences
SC Psychology; Behavioral Sciences
GA CA4OA
UT WOS:000348882900023
PM 25455867
ER
PT J
AU Loan, HK
Cuong, NV
Takhampunya, R
Kiet, BT
Campbell, J
Them, LN
Bryant, JE
Tippayachai, B
Hoang, NV
Morand, S
Hien, VB
Carrique-Mas, JJ
AF Hoang Kim Loan
Nguyen Van Cuong
Takhampunya, Ratree
Kiet, Bach Tuan
Campbell, James
Lac Ngoc Them
Bryant, Juliet E.
Tippayachai, Bousaraporn
Nguyen Van Hoang
Morand, Serge
Vo Be Hien
Carrique-Mas, Juan J.
TI How Important Are Rats As Vectors of Leptospirosis in the Mekong Delta
of Vietnam?
SO VECTOR-BORNE AND ZOONOTIC DISEASES
LA English
DT Article
DE Mekong Delta, Vietnam; Leptospirosis; Rats
ID RISK-FACTORS; PATHOGENIC LEPTOSPIRA; RODENTS; INTERROGANS;
SEROPOSITIVITY; ANTIBODIES; CARRIAGE; BRAZIL; ISLAND; SPP.
AB Leptospirosis is a zoonosis known to be endemic in the Mekong Delta of Vietnam, even though clinical reports are uncommon. We investigated leptospira infection in rats purchased in food markets during the rainy season (October) (n=150), as well as those trapped during the dry season (February-March) (n=125) in the region using RT-PCR for the lipL32 gene, confirmed by 16S rRNA, as well as by the microscopic agglutination test (MAT). Results were compared with the serovar distribution of human cases referred from Ho Chi Minh City hospitals (2004-2012) confirmed by MAT (n=45). The MAT seroprevalence among rats was 18.3%. The highest MAT seroprevalence corresponded, in decreasing order, to: Rattus norvegicus (33.0%), Bandicota indica (26.5%), Rattus tanezumi (24.6%), Rattus exulans (14.3%), and Rattus argentiventer (7.1%). The most prevalent serovars were, in descending order: Javanica (4.6% rats), Lousiana (4.2%), Copenageni (4.2%), Cynopterie (3.7%), Pomona (2.9%), and Icterohaemorrhagiae (2.5%). A total of 16 rats (5.8%) tested positive by RT-PCR. Overall, larger rats tended to have a higher prevalence of detection. There was considerable agreement between MAT and PCR (kappa=0.28 [0.07-0.49]), although significantly more rats were positive by MAT (McNemar 29.9 (p<0.001). MAT prevalence was higher among rats during the rainy season compared with rats in the dry season. There are no current available data on leptospira serovars in humans in the Mekong Delta, although existing studies suggest limited overlapping between human and rat serovars. Further studies should take into account a wider range of potential reservoirs (i.e., dogs, pigs) as well as perform geographically linked co-sampling of humans and animals to establish the main sources of leptospirosis in the region.
C1 [Hoang Kim Loan; Lac Ngoc Them] Inst Pasteur, Ho Chi Minh City, Vietnam.
[Nguyen Van Cuong; Campbell, James; Bryant, Juliet E.; Carrique-Mas, Juan J.] Univ Oxford, Clin Res Unit, Ho Chi Minh City, Vietnam.
[Takhampunya, Ratree; Campbell, James; Bryant, Juliet E.; Carrique-Mas, Juan J.] Univ Oxford, Nuffield Dept Med, Oxford, England.
[Kiet, Bach Tuan; Nguyen Van Hoang; Vo Be Hien] Subdept Anim Hlth, Dong Thap, Vietnam.
[Tippayachai, Bousaraporn] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
[Morand, Serge] Univ Montpellier 2, ISEM, CNRS, IRD, F-34095 Montpellier 5, France.
RP Carrique-Mas, JJ (reprint author), Univ Oxford, Clin Res Unit, Wellcome Trust Major Overseas Programme, 764 Vo Van Kiet,Ward 1,Dist 5, Ho Chi Minh City, Vietnam.
EM jcarrique-mas@oucru.org
FU Li-Ka-Shing Foundation; Wellcome Trust [WT/093724]; Agence Nationale de
la Recherche (France) [ANR-11-CEPL-002-01]
FX We are grateful to staff of the sub-Department of Animal Health in Dong
Thap province and to Yannick Chaval of the Centre Nationale de la
Recherche Scientifique for technical support. This work was partly
supported by the Li-Ka-Shing Foundation as well as the Wellcome
Trust-funded project Vietnam Initiative for Zoonotic Infections
(VIZIONS) (WT/093724). Dr. Serge Morand was funded by the Agence
Nationale de la Recherche (France) through ANR-11-CEPL-002-01, project
BioDivHealth SEA.
NR 36
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U1 2
U2 6
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1530-3667
EI 1557-7759
J9 VECTOR-BORNE ZOONOT
JI Vector-Borne Zoonotic Dis.
PD JAN 1
PY 2015
VL 15
IS 1
SI SI
BP 56
EP 64
DI 10.1089/vbz.2014.1613
PG 9
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA AZ9YM
UT WOS:000348570600008
PM 25629781
ER
PT J
AU Conger, NG
Paolino, KM
Osborn, EC
Rusnak, JM
Gunther, S
Pool, J
Rollin, PE
Allan, PF
Schmidt-Chanasit, J
Rieger, T
Kortepeter, MG
AF Conger, Nicholas G.
Paolino, Kristopher M.
Osborn, Erik C.
Rusnak, Janice M.
Guenther, Stephan
Pool, Jane
Rollin, Pierre E.
Allan, Patrick F.
Schmidt-Chanasit, Jonas
Rieger, Toni
Kortepeter, Mark G.
TI Health Care Response to CCHF in US Soldier and Nosocomial Transmission
to Health Care Providers, Germany, 2009
SO EMERGING INFECTIOUS DISEASES
LA English
DT Article
ID CONGO HEMORRHAGIC-FEVER; SERUM-LEVELS; VIRAL LOAD; VIRUS; ACTIVATION;
TURKEY; CELLS; PATHOGENESIS; INTERFERON; PROGNOSIS
AB In 2009, a lethal case of Crimean Congo hemorrhagic fever (CCHF), acquired by a US soldier in Afghanistan, was treated at a medical center in Germany and resulted in nosocomial transmission to 2 health care providers (HCPs). After his arrival at the medical center (day 6 of illness) by aeromedical evacuation, the patient required repetitive bronchoscopies to control severe pulmonary hemorrhage and renal and hepatic dialysis for hepatorenal failure. After showing clinical improvement, the patient died suddenly on day 11 of illness from cerebellar tonsil herniation caused by cerebral/cerebellar edema. The 2 infected HCPs were among 16 HCPs who received ribavirin postexposure prophylaxis. The infected HCPs had mild or no CCHF symptoms. Transmission may have occurred during bag-valve-mask ventilation, breaches in personal protective equipment during resuscitations, or bronchoscopies generating infectious aerosols. This case highlights the critical care and infection control challenges presented by severe CCHF cases, including the need for experience with ribavirin treatment and postexposure prophylaxis.
C1 [Conger, Nicholas G.; Osborn, Erik C.; Pool, Jane; Allan, Patrick F.] Landstuhl Reg Med Ctr, Landstuhl, Germany.
[Paolino, Kristopher M.] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Rusnak, Janice M.] Force Hlth Protect, Ft Detrick, MD USA.
[Guenther, Stephan; Schmidt-Chanasit, Jonas; Rieger, Toni] Bernhard Nocht Inst Trop Med, D-20359 Hamburg, Germany.
[Rollin, Pierre E.] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Kortepeter, Mark G.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
RP Conger, NG (reprint author), Wright Patterson Med Ctr, 4881 Sugar Maple Dr, Wright Patterson AFB, OH 45433 USA.
EM nicholas.conger@us.af.mil
NR 40
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Z9 16
U1 0
U2 3
PU CENTERS DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1080-6040
EI 1080-6059
J9 EMERG INFECT DIS
JI Emerg. Infect. Dis
PD JAN
PY 2015
VL 21
IS 1
BP 23
EP 31
DI 10.3201/eid2101.141413
PG 9
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA AY3SW
UT WOS:000347503700004
PM 25529825
ER
PT J
AU Kessler, RC
Warner, CH
Ivany, C
Petukhova, MV
Rose, S
Bromet, EJ
Brown, M
Cai, TX
Colpe, LJ
Cox, KL
Fullerton, CS
Gilman, SE
Gruber, MJ
Heeringa, SG
Lewandowski-Romps, L
Li, JL
Millikan-Bell, A
Naifeh, JA
Nock, MK
Rosellini, AJ
Sampson, NA
Schoenbaum, M
Stein, MB
Wessely, S
Zaslavsky, AM
Ursano, RJ
AF Kessler, Ronald C.
Warner, Christopher H.
Ivany, Christopher
Petukhova, Maria V.
Rose, Sherri
Bromet, Evelyn J.
Brown, Millard, III
Cai, Tianxi
Colpe, Lisa J.
Cox, Kenneth L.
Fullerton, Carol S.
Gilman, Stephen E.
Gruber, Michael J.
Heeringa, Steven G.
Lewandowski-Romps, Lisa
Li, Junlong
Millikan-Bell, Amym.
Naifeh, James A.
Nock, Matthew K.
Rosellini, Anthony J.
Sampson, Nancy A.
Schoenbaum, Michael
Stein, Murray B.
Wessely, Simon
Zaslavsky, Alan M.
Ursano, Robert J.
CA Army STARRS Collaborators
TI Predicting Suicides After Psychiatric Hospitalization in US Army
Soldiers The Army Study to Assess Risk and Resilience in Servicemembers
(Army STARRS)
SO JAMA PSYCHIATRY
LA English
DT Article
ID DECISION-SUPPORT-SYSTEMS; INPATIENT CARE; PREVENTION; DISCHARGE;
METAANALYSIS; REGRESSION; DEPRESSION; ATTEMPTORS; BEHAVIOR; PERIODS
AB IMPORTANCE The US Army experienced a sharp increase in soldier suicides beginning in 2004. Administrative data reveal that among those at highest risk are soldiers in the 12 months after inpatient treatment of a psychiatric disorder.
OBJECTIVE To develop an actuarial risk algorithm predicting suicide in the 12 months after US Army soldier inpatient treatment of a psychiatric disorder to target expanded posthospitalization care.
DESIGN, SETTING, AND PARTICIPANTS There were 53 769 hospitalizations of active duty soldiers from January 1, 2004, through December 31, 2009, with International Classification of Diseases, Ninth Revision, Clinical Modification psychiatric admission diagnoses. Administrative data available before hospital discharge abstracted from a wide range of data systems (sociodemographic, US Army career, criminal justice, and medical or pharmacy) were used to predict suicides in the subsequent 12 months using machine learning methods (regression trees and penalized regressions) designed to evaluate cross-validated linear, nonlinear, and interactive predictive associations.
MAIN OUTCOMES AND MEASURES Suicides of soldiers hospitalized with psychiatric disorders in the 12 months after hospital discharge.
RESULTS Sixty-eight soldiers died by suicide within 12 months of hospital discharge (12.0% of all US Army suicides), equivalent to 263.9 suicides per 100 000 person-years compared with 18.5 suicides per 100 000 person-years in the total US Army. The strongest predictors included sociodemographics (male sex [odds ratio (OR), 7.9; 95% CI, 1.9-32.6] and late age of enlistment [OR, 1.9; 95% CI, 1.0-3.5]), criminal offenses (verbal violence [OR, 2.2; 95% CI, 1.2-4.0] and weapons possession [OR, 5.6; 95% CI, 1.7-18.3]), prior suicidality [OR, 2.9; 95% CI, 1.7-4.9], aspects of prior psychiatric inpatient and outpatient treatment (eg, number of antidepressant prescriptions filled in the past 12 months [OR, 1.3; 95% CI, 1.1-1.7]), and disorders diagnosed during the focal hospitalizations (eg, nonaffective psychosis [OR, 2.9; 95% CI, 1.2-7.0]). A total of 52.9% of posthospitalization suicides occurred after the 5% of hospitalizations with highest predicted suicide risk (3824.1 suicides per 100 000 person-years). These highest-risk hospitalizations also accounted for significantly elevated proportions of several other adverse posthospitalization outcomes (unintentional injury deaths, suicide attempts, and subsequent hospitalizations).
CONCLUSIONS AND RELEVANCE The high concentration of risk of suicide and other adverse outcomes might justify targeting expanded posthospitalization interventions to soldiers classified as having highest posthospitalization suicide risk, although final determination requires careful consideration of intervention costs, comparative effectiveness, and possible adverse effects.
C1 [Kessler, Ronald C.; Petukhova, Maria V.; Rose, Sherri; Gruber, Michael J.; Rosellini, Anthony J.; Sampson, Nancy A.; Zaslavsky, Alan M.] Harvard Univ, Sch Med, Dept Hlth Care Policy, Boston, MA 02115 USA.
[Warner, Christopher H.] Blanchfield Army Community Hosp, Dept Behav Med, Ft Campbell, KY USA.
[Ivany, Christopher; Brown, Millard, III] US Army Off Surg Gen, Falls Church, VA USA.
[Bromet, Evelyn J.] SUNY Stony Brook, Sch Med, Dept Psychiat, Stony Brook, NY 11794 USA.
[Cai, Tianxi; Li, Junlong] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA.
[Colpe, Lisa J.; Schoenbaum, Michael] NIMH, Bethesda, MD 20892 USA.
[Cox, Kenneth L.; Millikan-Bell, Amym.] US Army Publ Hlth Command, Aberdeen Proving Ground, MD USA.
[Fullerton, Carol S.; Naifeh, James A.; Ursano, Robert J.] Uniformed Serv Univ Hlth Sci, Ctr Study Traumat Stress, Bethesda, MD 20814 USA.
[Gilman, Stephen E.] Harvard Univ, Sch Publ Hlth, Dept Social & Behav Sci, Boston, MA 02115 USA.
[Gilman, Stephen E.] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
[Heeringa, Steven G.; Lewandowski-Romps, Lisa] Univ Michigan, Inst Social Res, Ann Arbor, MI USA.
[Nock, Matthew K.] Harvard Univ, Dept Psychol, Cambridge, MA 02138 USA.
[Stein, Murray B.] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA.
[Stein, Murray B.] Univ Calif San Diego, Deapartment Family & Prevent Med, La Jolla, CA 92093 USA.
[Stein, Murray B.] Vet Affairs San Diego Healthcare Syst, San Diego, CA USA.
[Wessely, Simon] Kings Coll London, Kings Ctr Mil Hlth Res, London WC2R 2LS, England.
RP Kessler, RC (reprint author), Harvard Univ, Sch Med, Dept Hlth Care Policy, 180 Longwood Ave,Ste 215, Boston, MA 02115 USA.
EM kessler@hcp.med.harvard.edu
RI Gilman, Stephen/E-7632-2010; Wessely, Simon/A-8713-2008
OI Gilman, Stephen/0000-0002-8331-6419;
FU US Department of the Army; National Institute of Mental Health, National
Institutes of Health, US Department of Health and Human Services;
[U01MH087981]
FX The Army STARRS was sponsored by the US Department of the Army and
funded under cooperative agreement U01MH087981 with the National
Institute of Mental Health, National Institutes of Health, US Department
of Health and Human Services.
NR 48
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PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-622X
EI 2168-6238
J9 JAMA PSYCHIAT
JI JAMA Psychiatry
PD JAN
PY 2015
VL 72
IS 1
BP 49
EP 57
DI 10.1001/jamapsychiatry.2014.1754
PG 9
WC Psychiatry
SC Psychiatry
GA AY5KJ
UT WOS:000347610700007
PM 25390793
ER
PT J
AU Bailie, JM
Cole, WR
Ivins, B
Boyd, C
Lewis, S
Neff, J
Schwab, K
AF Bailie, Jason M.
Cole, Wesley R.
Ivins, Brian
Boyd, Cynthia
Lewis, Steven
Neff, John
Schwab, Karen
TI The Experience, Expression, and Control of Anger Following Traumatic
Brain Injury in a Military Sample
SO JOURNAL OF HEAD TRAUMA REHABILITATION
LA English
DT Article
DE anger; explosive blast injury; military injury; traumatic brain injury
ID POSTTRAUMATIC-STRESS-DISORDER; AFGHANISTAN WAR VETERANS; HEAD-INJURY;
MANAGEMENT THERAPY; AGGRESSION; MILD; IRAQ; IRRITABILITY; HOSTILITY;
SYMPTOMS
AB Objective: To investigate the impact of traumatic brain injury (TBI) on the experience and expression of anger in a military sample. Participants: A total of 661 military personnel with a history of TBI and 1204 military personnel with no history of TBI. Design: Cross-sectional, between-group design, using multivariate analysis of variance. Main Measure: State-Trait Anger Expression Inventory-2 (STAXI-2). Results: Participants with a history of TBI had higher scores on the STAXI-2 than controls and were 2 to 3 times more likely than the participants in the control group to have at least 1 clinically significant elevation on the STAXI-2. Results suggested that greater time since injury (ie, months between TBI and assessment) was associated with lower scores on the STAXI-2 State Anger scale. Conclusion: Although the results do not take into account confounding psychiatric conditions and cannot address causality, they suggest that a history of TBI increases the risk of problems with the experience, expression, and control of anger. This bolsters the need for proper assessment of anger when evaluating TBI in a military cohort.
C1 [Bailie, Jason M.; Boyd, Cynthia; Neff, John] Naval Med Ctr San Diego, Def & Vet Brain Injury Ctr, San Diego, CA 92134 USA.
[Bailie, Jason M.; Cole, Wesley R.; Boyd, Cynthia] Adv Mil Med Inc, Henry M Jackson Fdn, Bethesda, MD USA.
[Ivins, Brian] Adv Mil Med Inc, Henry M Jackson Fdn, Washington, DC USA.
[Ivins, Brian] Def & Vet Brain Injury Ctr, Washington, DC USA.
[Cole, Wesley R.; Lewis, Steven] Def & Vet Brain Injury Ctr, Ft Bragg, NC USA.
[Lewis, Steven] Womack Army Med Ctr, Dept Traumat Brain Injury, Ft Bragg, NC USA.
[Neff, John] US Navy, Rehabil Med, San Diego, CA 92152 USA.
[Schwab, Karen] Def & Vet Brain Injury Ctr, Epidemiol & Res Support Serv, Washington, DC USA.
RP Bailie, JM (reprint author), Naval Med Ctr San Diego, Def & Vet Brain Injury Ctr, 34730 Bob Wilson Dr,Ste 201, San Diego, CA 92134 USA.
EM jason.bailie.ctr@med.navy.mil
FU [W91YTZ-12-C-0132]
FX Research on this article was done under contract # W91YTZ-12-C-0132.
NR 40
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PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0885-9701
EI 1550-509X
J9 J HEAD TRAUMA REHAB
JI J. Head Trauma Rehabil.
PD JAN-FEB
PY 2015
VL 30
IS 1
BP 12
EP 20
DI 10.1097/HTR.0000000000000024
PG 9
WC Clinical Neurology; Rehabilitation
SC Neurosciences & Neurology; Rehabilitation
GA AY8BW
UT WOS:000347780400010
PM 24590149
ER
PT J
AU Pugh, MJV
Orman, JA
Jaramillo, CA
Salinsky, MC
Eapen, BC
Towne, AR
Amuan, ME
Roman, G
McNamee, SD
Kent, TA
McMillan, KK
Hamid, H
Grafman, JH
AF Pugh, Mary Jo V.
Orman, Jean A.
Jaramillo, Carlos A.
Salinsky, Martin C.
Eapen, Blessen C.
Towne, Alan R.
Amuan, Megan E.
Roman, Gustavo
McNamee, Shane D.
Kent, Thomas A.
McMillan, Katharine K.
Hamid, Hamada
Grafman, Jordan H.
TI The Prevalence of Epilepsy and Association With Traumatic Brain Injury
in Veterans of the Afghanistan and Iraq Wars
SO JOURNAL OF HEAD TRAUMA REHABILITATION
LA English
DT Article
DE epidemiology; epilepsy; traumatic brain injury; Veterans
ID ONSET UNPROVOKED SEIZURES; PENETRATING HEAD-INJURY; POSTTRAUMATIC
EPILEPSY; BIDIRECTIONAL RELATION; ADMINISTRATIVE DATA; ANTIEPILEPTIC
DRUG; CHRONIC PAIN; DISORDERS; COMORBIDITY; HYPERTENSION
AB Objective: To examine the association of epilepsy with traumatic brain injury (TBI) in Afghanistan and Iraq (Operation Enduring Freedom [OEF]/Operation Iraqi Freedom [OIF]) Veterans. Design: Cross-sectional observational study. Participants: A total 256 284 OEF/OIF Veterans who received inpatient and outpatient care in the Veterans Health Administration in fiscal years 2009-2010. Main Outcome Measures: We used algorithms developed for use with International Classification of Diseases, Ninth Revision, Clinical Modification, codes to identify epilepsy, TBI (penetrating TBI [pTBI]/other TBI), and other risk factors for epilepsy (eg, stroke). TBI and other risk factors were identified prior to the index date (first date of seizure or October 1, 2009) for primary analyses. Results: Epilepsy prevalence was 10.6 per 1000 (N = 2719) in fiscal year 2010; age-adjusted prevalence was 6.1. Of 37 718 individuals with a diagnosis of TBI, 29 297 Veterans had a diagnosis of TBI prior to the index date. Statistically significant associations were found between epilepsy and prior TBI diagnosis (pTBI: adjusted odds ratio = 18.77 [95% confidence interval, 9.21-38.23]; other TBI: adjusted odds ratio = 1.64 [1.43-1.89]). Conclusions: Among OEF/OIF Veterans, epilepsy was associated with previous TBI diagnosis, with pTBI having the strongest association. Because war-related epilepsy in Vietnam War Veterans with TBI continued 35 years postwar, a detailed, prospective study is needed to understand the relationship between epilepsy and TBI severity in OEF/OIF Veterans.
C1 [Pugh, Mary Jo V.; McMillan, Katharine K.] South Texas Vet Hlth Care Syst VERDICT, San Antonio, TX USA.
[Pugh, Mary Jo V.; Orman, Jean A.; McMillan, Katharine K.] Univ Texas Hlth Sci Ctr San Antonio, Dept Epidemiol & Biostat, San Antonio, TX 78229 USA.
[Pugh, Mary Jo V.] Texas A&M Univ, Dept Med, Sch Med, College Stn, TX 77843 USA.
[Orman, Jean A.] US Army Inst Surg Res, Houston, TX USA.
[Orman, Jean A.] Univ Texas San Antonio, Sch Publ Hlth, San Antonio, TX USA.
[Jaramillo, Carlos A.; Eapen, Blessen C.] UT Hlth Sci Ctr San Antonio, Dept Rehabil Med, Polytrauma Rehabil Ctr South Texas Vet Hlth Care, San Antonio, TX USA.
[Salinsky, Martin C.] Portland VA Med Ctr, Portland, OR USA.
[Salinsky, Martin C.] Oregon Hlth & Sci Univ, Portland, OR 97201 USA.
[Towne, Alan R.] Virginia Commonwealth Univ, Richmond, VA 23284 USA.
[Towne, Alan R.] McGuire Vet Adm Hosp, Epilepsy Ctr Excellence, Richmond, VA USA.
[Amuan, Megan E.] Edith Nourse Rogers Mem Hosp, CHQOER, Bedford, MA USA.
[Roman, Gustavo] Methodist Neurol Inst, Nantz Natl Alzheimer Ctr, Houston, TX USA.
[McNamee, Shane D.] Hunter Holmes McGuire Vet Adm Hosp, Phys Med & Rehabil Serv, Richmond, VA USA.
[Kent, Thomas A.] Michael E DeBakey VA Med Ctr, Houston, TX USA.
[Kent, Thomas A.] Baylor Coll Med, Houston, TX 77030 USA.
[Hamid, Hamada] West Haven VA Med Ctr, West Haven, CT USA.
[Grafman, Jordan H.] Rehabil Inst Chicago, Chicago, IL 60611 USA.
RP Pugh, MJV (reprint author), South Texas Vet Hlth Care Syst ALMD, 7400 Merton Minter Blvd 11C6, San Antonio, TX 78229 USA.
EM pughm@uthscsa.edu
OI Kent, Thomas/0000-0002-9877-7584; Grafman, Jordan H./0000-0001-8645-4457
FU VA Health Services Research and Development [DHI 09-237]
FX The study was funded by VA Health Services Research and Development (DHI
09-237). Administrative, technical, or material support was provided by
Kathleen Franklin, South Texas Veterans Healthcare System. Data analysis
was conducted by Ms Amuan.
NR 51
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U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0885-9701
EI 1550-509X
J9 J HEAD TRAUMA REHAB
JI J. Head Trauma Rehabil.
PD JAN-FEB
PY 2015
VL 30
IS 1
BP 29
EP 37
DI 10.1097/HTR.0000000000000045
PG 9
WC Clinical Neurology; Rehabilitation
SC Neurosciences & Neurology; Rehabilitation
GA AY8BW
UT WOS:000347780400012
PM 24695268
ER
PT J
AU Carr, W
Polejaeva, E
Grome, A
Crandall, B
LaValle, C
Eonta, SE
Young, LA
AF Carr, Walter
Polejaeva, Elena
Grome, Anna
Crandall, Beth
LaValle, Christina
Eonta, Stephanie E.
Young, Lee Ann
TI Relation of Repeated Low-Level Blast Exposure With Symptomology Similar
to Concussion
SO JOURNAL OF HEAD TRAUMA REHABILITATION
LA English
DT Article
DE blast; concussion; military; survey; symptoms
ID TRAUMATIC BRAIN-INJURY; POSTTRAUMATIC-STRESS-DISORDER;
OPERATION-IRAQI-FREEDOM; POSTCONCUSSIVE SYMPTOMS; HEAD-INJURY; HEALTH;
ASSOCIATION; MECHANISMS; PERSONNEL; SEQUELAE
AB Objective: To investigate anecdotal reports suggesting that repeated exposure to low-level explosive blast has myriad health impacts, including an array of neurological effects. Participants: A total of 184 anonymous survey respondents from military and nonmilitary law enforcement populations (135 exposed to occupational blast and 49 controls). Design: Survey of self-reported history of occupational exposure to repeated low-level blast (breaching blast) and symptomology similar to concussion. Results: Findings suggest that number and severity of symptoms increase with history of chronic blast exposure (F = 18.26, P < .001) and that symptoms can interfere with daily activity (t = 2.60, P = .010). Conclusion: Given the prevalence of repeated exposure to blast among some military and civilian law enforcement occupations, the results of this survey study support a role for blast surveillance programs as well as continued research on health impacts of low-level repeated blast exposure.
C1 [Carr, Walter; LaValle, Christina; Eonta, Stephanie E.] Walter Reed Army Inst Res, Dept Behav Biol, Silver Spring, MD 20910 USA.
[Polejaeva, Elena] Naval Med Res Ctr, Dept Neurotrauma, Silver Spring, MD USA.
[Grome, Anna; Crandall, Beth; Young, Lee Ann] Appl Res Associates, Albuquerque, NM USA.
RP Carr, W (reprint author), Walter Reed Army Inst Res, Dept Behav Biol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM walter.s.carr.mil@mail.mil
FU Army MOMRP.accelleration.A0908
FX This work was supported by Army MOMRP.accelleration.A0908.
NR 37
TC 5
Z9 5
U1 2
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0885-9701
EI 1550-509X
J9 J HEAD TRAUMA REHAB
JI J. Head Trauma Rehabil.
PD JAN-FEB
PY 2015
VL 30
IS 1
BP 47
EP 55
DI 10.1097/HTR.0000000000000064
PG 9
WC Clinical Neurology; Rehabilitation
SC Neurosciences & Neurology; Rehabilitation
GA AY8BW
UT WOS:000347780400014
PM 24901327
ER
PT J
AU Krishnaraj, A
Norbash, A
Allen, B
Ellenbogen, PH
Kazerooni, EA
Thorwarth, W
Weinreb, JC
AF Krishnaraj, Arun
Norbash, Alexander
Allen, Bibb, Jr.
Ellenbogen, Paul H.
Kazerooni, Ella A.
Thorwarth, William, Jr.
Weinreb, Jeffley C.
TI The Impact of the Patient Protection and Affordable Care Act on
Radiology: Beyond Reimbursement
SO JOURNAL OF THE AMERICAN COLLEGE OF RADIOLOGY
LA English
DT Article
DE ACR Forum; Affordable Care Act; patient experience; population health;
public health; value proposition
ID HEALTH; COST; FUTURE; FORUM
AB The 2014 ACR Forum focused on the noneconomic implications of the Affordable Care Act on the field of radiology, with specific attention to the importance of the patient experience, the role of radiology in public and population health, and radiology's role in the T effort to lower overall health care costs. The recommendations generated from the Forum seek to inform ACR leadership on the best, strategies to pursue to best prepare the radiology community for the rapidly evolving health care landscape.
C1 [Krishnaraj, Arun] Univ Virginia, Charlottesville, VA 22908 USA.
[Norbash, Alexander] Boston Univ, Sch Med, Boston, MA 02118 USA.
[Allen, Bibb, Jr.] Tripler Army Med Ctr, Birmingham, AL USA.
[Ellenbogen, Paul H.] Presbyterian Med Ctr, Dallas, TX USA.
[Kazerooni, Ella A.] Univ Michigan, Ann Arbor, MI 48109 USA.
[Thorwarth, William, Jr.] ACR, Reston, VA USA.
[Weinreb, Jeffley C.] Yale Univ, Sch Med, New Haven, CT USA.
RP Krishnaraj, A (reprint author), Univ Virginia Hlth Syst, 1215 Lee St,POB 800170, Charlottesville, VA 22908 USA.
EM ak8jj@virginia.edu
NR 15
TC 0
Z9 0
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1546-1440
J9 J AM COLL RADIOL
JI J. Am. Coll. Radiol.
PD JAN
PY 2015
VL 12
IS 1
BP 29
EP 33
DI 10.1016/j.jacr.2014.09.035
PG 5
WC Radiology, Nuclear Medicine & Medical Imaging
SC Radiology, Nuclear Medicine & Medical Imaging
GA AY7NT
UT WOS:000347747400011
PM 25557569
ER
PT J
AU Nirujogi, RS
Wright, JD
Manda, SS
Zhong, J
Na, CH
Meyerhoff, J
Benton, B
Jabbour, R
Willis, K
Kim, MS
Pandey, A
Sekowski, JW
AF Nirujogi, Raja Sekhar
Wright, James D., Jr.
Manda, Srikanth S.
Zhong, Jun
Na, Chan Hyun
Meyerhoff, James
Benton, Bernard
Jabbour, Rabih
Willis, Kristen
Kim, Min-Sik
Pandey, Akhilesh
Sekowski, Jennifer W.
TI Phosphoproteomic analysis reveals compensatory effects in the piriform
cortex of VX nerve agent exposed rats
SO PROTEOMICS
LA English
DT Article
DE Animal proteomics; Phosphoproteomics; Piriform cortex; Signal
transduction; VX
ID GLYCOGEN-SYNTHASE KINASE-3; ADRENERGIC-RECEPTOR KINASE; SPLICING
FACTORS; SIGNALING PATHWAY; INDUCED SEIZURES; PROTEIN-KINASE;
LOCALIZATION; HIPPOCAMPUS; BRAIN; SOMAN
AB To gain insights into the toxicity induced by the nerve agent VX, an MS-based phosphoproteomic analysis was carried out on the piriform cortex region of brains from VX-treated rats. Using isobaric tag based TMT labeling followed by titanium dioxide enrichment strategy, we identified 9975 unique phosphosites derived from 3287 phosphoproteins. Temporal changes in the phosphorylation status of peptides were observed over a time period of 24 h in rats exposed to a 1x LD50, intravenous (i.v.) dose with the most notable changes occurring at the 1 h postexposure time point. Five major functional classes of proteins exhibited changes in their phosphorylation status: (i) ion channels/transporters, including ATPases, (ii) kinases/phosphatases, (iii) GTPases, (iv) structural proteins, and (v) transcriptional regulatory proteins. This study is the first quantitative phosphoproteomic analysis of VX toxicity in the brain. Understanding the toxicity and compensatory signaling mechanisms will improve the understanding of the complex toxicity of VX in the brain and aid in the elucidation of novel molecular targets that would be important for development of improved countermeasures. All MS data have been deposited in the ProteomeXchange with identifier PXD001184 (http://proteomecentral.proteomexchange.org/dataset/PXD001184).
C1 [Nirujogi, Raja Sekhar; Manda, Srikanth S.] Inst Bioinformat, Bangalore, Karnataka, India.
[Nirujogi, Raja Sekhar; Manda, Srikanth S.] Pondicherry Univ, Sch Life Sci, Ctr Bioinformat, Pondicherry, India.
[Nirujogi, Raja Sekhar] Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA.
[Wright, James D., Jr.; Benton, Bernard; Jabbour, Rabih; Sekowski, Jennifer W.] US Army Edgewood Chem Biol Ctr, Res & Technol Directorate, Aberdeen Proving Ground, MD USA.
[Manda, Srikanth S.; Na, Chan Hyun] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA.
[Zhong, Jun; Willis, Kristen] Def Threat Reduct Agcy, Ft Belvoir, VA USA.
[Meyerhoff, James] Oakridge Inst Sci & Engn, Oakridge, TN USA.
[Kim, Min-Sik; Pandey, Akhilesh] Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Baltimore, MD USA.
[Pandey, Akhilesh] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA.
[Pandey, Akhilesh] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA.
RP Sekowski, JW (reprint author), US Army ECBC, 5183 Blackhawk Rd,RDCB DRB D, Aberdeen Proving Ground, MD 21010 USA.
EM jennifer.w.sekowski.civ@mail.mil
RI Zhong, Jun/D-1662-2010; Kim, Min-Sik/M-3488-2016;
OI Zhong, Jun/0000-0003-3148-4143; Kim, Min-Sik/0000-0001-7317-5360;
Sekowski, Jennifer/0000-0003-4561-640X
FU Joint Science and Technology Office (JSTO); CB-A Division of the Defense
Threat Reduction Agency (DTRA); Council of Scientific and Industrial
Research (CSIR), Government of India; University Grants Commission
(UGC), India
FX The authors thank Christopher Phillips, David McCaskey, John Pence,
Steven Yee, and Daniel Carmany for their expertise in dosing animals,
performing euthanasia, and assisting in the removal and storage of
tissues. This work was supported by a grant from the Joint Science and
Technology Office (JSTO), CB-A Division of the Defense Threat Reduction
Agency (DTRA) (JWS and AP). RSN is a recipient of Senior Research
Fellowship from Council of Scientific and Industrial Research (CSIR),
Government of India. SSM is a recipient of Senior Research Fellowship
from the University Grants Commission (UGC), India.
NR 64
TC 2
Z9 2
U1 0
U2 15
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1615-9853
EI 1615-9861
J9 PROTEOMICS
JI Proteomics
PD JAN
PY 2015
VL 15
IS 2-3
SI SI
BP 487
EP 499
DI 10.1002/pmic.201400371
PG 13
WC Biochemical Research Methods; Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA AY9UI
UT WOS:000347895500028
PM 25403869
ER
PT J
AU Rezk, PE
Zdenka, P
Sabnekar, P
Kajih, T
Mata, DG
Wrobel, C
Cerasoli, DM
Chilukuri, N
AF Rezk, Peter E.
Zdenka, Pierre
Sabnekar, Praveena
Kajih, Takwen
Mata, David G.
Wrobel, Chester
Cerasoli, Douglas M.
Chilukuri, Nageswararao
TI An in vitro and in vivo evaluation of the efficacy of recombinant human
liver prolidase as a catalytic bioscavenger of chemical warfare nerve
agents
SO DRUG AND CHEMICAL TOXICOLOGY
LA English
DT Article
DE Adenovirus; butyrylcholinesterase; catalytic bioscavenger; chemical
warfare nerve agents; human liver prolidase; in vivo delivery
ID ORGANOPHOSPHORUS ACID ANHYDROLASE; HUMAN BUTYRYLCHOLINESTERASE; KIDNEY
PROLIDASE; INDUCED SEIZURES; SOMAN TOXICITY; PROTECTION; PURIFICATION;
SARIN; PYRIDOSTIGMINE; PRETREATMENT
AB In this study, we determined the ability of recombinant human liver prolidase to hydrolyze nerve agents in vitro and its ability to afford protection in vivo in mice. Using adenovirus containing the human liver prolidase gene, the enzyme was over expressed by 200- to 300-fold in mouse liver and purified to homogeneity by affinity and gel filtration chromatography. The purified enzyme hydrolyzed sarin, cyclosarin and soman with varying rates of hydrolysis. The most efficient hydrolysis was with sarin, followed by soman and by cyclosarin {apparent k(cat)/K-m [(1.9 +/- 0.3), (1.7 +/- 0.2), and (0.45 +/- 0.04)] x 10(5) M-1 min(-1), respectively}; VX and tabun were not hydrolyzed by the recombinant enzyme. The enzyme hydrolyzed P (+) isomers faster than the P (+) isomers. The ability of recombinant human liver prolidase to afford 24 hour survival against a cumulative dose of 2 x LD50 of each nerve agent was investigated in mice. Compared to mice injected with a control virus, mice injected with the prolidase expressing virus contained (29 +/- 7)-fold higher levels of the enzyme in their blood on day 5. Challenging these mice with two consecutive 1 x LD50 doses of sarin, cyclosarin, and soman resulted in the death of all animals within 5 to 8 min from nerve agent toxicity. In contrast, mice injected with the adenovirus expressing mouse butyrylcholinesterase, an enzyme which is known to afford protection in vivo, survived multiple 1 x LD50 challenges of these nerve agents and displayed no signs of toxicity. These results suggest that, while prolidase can hydrolyze certain G-type nerve agents in vitro, the enzyme does not offer 24 hour protection against a cumulative dose of 2 x LD50 of G-agents in mice in vivo.
C1 [Rezk, Peter E.; Zdenka, Pierre; Sabnekar, Praveena; Kajih, Takwen; Mata, David G.; Wrobel, Chester; Cerasoli, Douglas M.; Chilukuri, Nageswararao] US Army Med Res Inst Chem Def, Physiol & Immunol Branch, Div Res, Aberdeen Proving Ground, MD 21010 USA.
RP Chilukuri, N (reprint author), US Army Med Res Inst Chem Def, Physiol & Immunol Branch, Div Res, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA.
EM Nageswararao.chilukuri.civ@mail.mil
FU Defense Threat Reduction Agency-Joint Science and Technology Office,
Medical ST Division [D0003_09_RC_C]
FX This research was supported by the Defense Threat Reduction Agency
(Project ID: D0003_09_RC_C)-Joint Science and Technology Office, Medical
S&T Division. The views expressed in this manuscript are those of the
author(s) and do not reflect the official policy of the Department of
Army, Department of Defense, or the U.S. Government. The experimental
protocol was approved by the Animal Care and Use Committee of the US
Army Medical Research Institute of Chemical Defense, Aberdeen Proving
Ground, MD and all procedures were conducted in accordance with the
principles stated in the Guide for the Care and Use of Laboratory
Animals (National Research Council), and the Animal Welfare Act of 1966
(P.L. 89-544), as amended. The authors are grateful to Dr. John
McDonough, USAMRICD, for help with the animal experiments and
suggestions with the manuscript.
NR 39
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U1 1
U2 27
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0148-0545
EI 1525-6014
J9 DRUG CHEM TOXICOL
JI Drug Chem. Toxicol.
PD JAN
PY 2015
VL 38
IS 1
BP 37
EP 43
DI 10.3109/01480545.2014.900071
PG 7
WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy; Toxicology
SC Chemistry; Pharmacology & Pharmacy; Toxicology
GA AY0XE
UT WOS:000347316800006
PM 24641262
ER
PT J
AU Miller, RS
Weaver, LK
Bahraini, N
Churchill, S
Price, RC
Skiba, V
Caviness, J
Mooney, S
Hetzell, B
Liu, J
Deru, K
Ricciardi, R
Fracisco, S
Close, NC
Surrett, GW
Bartos, C
Ryan, M
Brenner, LA
AF Miller, R. Scott
Weaver, Lindell K.
Bahraini, Nazanin
Churchill, Susan
Price, Robert C.
Skiba, Virginia
Caviness, James
Mooney, Scott
Hetzell, Brian
Liu, Jun
Deru, Kayla
Ricciardi, Richard
Fracisco, Susan
Close, Nicole C.
Surrett, Gerald W.
Bartos, Corinna
Ryan, Margaret
Brenner, Lisa A.
CA HOPPS Trial Team
TI Effects of Hyperbaric Oxygen on Symptoms and Quality of Life Among
Service Members With Persistent Postconcussion Symptoms A Randomized
Clinical Trial
SO JAMA INTERNAL MEDICINE
LA English
DT Article
ID TRAUMATIC BRAIN-INJURY; POST-CONCUSSION SYNDROME;
POSTTRAUMATIC-STRESS-DISORDER; MILD TBI; MILITARY; BLAST; RELIABILITY;
COMPLAINTS; QUESTIONNAIRE; MANAGEMENT
AB IMPORTANCE Improvement has been anecdotally observed in patients with persistent postconcussion symptoms (PCS) after mild traumatic brain injury following treatment with hyperbaric oxygen (HBO). The effectiveness of HBO as an adjunctive treatment for PCS is unknown to date.
OBJECTIVES To compare the safety of and to estimate the efficacy for symptomatic outcomes from standard PCS care alone, care supplemented with HBO, or a sham procedure.
DESIGN, SETTING, AND PARTICIPANTS Multicenter, double-blind, sham-controlled clinical trial of 72 military service members with ongoing symptoms at least 4 months after mild traumatic brain injury enrolled at military hospitals in Colorado, North Carolina, California, and Georgia between April 26, 2011, and August 24, 2012. Assessments occurred before randomization, at the midpoint, and within 1 month after completing the interventions.
INTERVENTIONS Routine PCS care was provided in specialized clinics. In addition, participants were randomized 1: 1: 1 to 40 HBO sessions administered at 1.5 atmospheres absolute (ATA), 40 sham sessions consisting of room air at 1.2 ATA, or no supplemental chamber procedures.
MAIN OUTCOMES AND MEASURES The Rivermead Post-Concussion Symptoms Questionnaire (RPQ) served as the primary outcome measure. A change score of at least 2 points on the RPQ-3 subscale (range, 0-12) was defined as clinically significant. Change scores from baseline were calculated for the RPQ-3 and for the total RPQ. Secondary measures included additional patient-reported outcomes and automated neuropsychometric testing.
RESULTS On average, participants had sustained 3 lifetime mild traumatic brain injuries; the most recent occurred 23 months before enrollment. No differences were observed between groups for improvement of at least 2 points on the RPQ-3 subscale (25% in the no intervention group, 52% in the HBO group, and 33% in the sham group; P=.24). Compared with the no intervention group (mean change score, 0.5; 95% CI, -4.8 to 5.8; P=.91), both groups undergoing supplemental chamber procedures showed improvement in symptoms on the RPQ (mean change score, 5.4; 95% CI, -0.5 to 11.3; P=.008 in the HBO group and 7.0; 95% CI, 1.0-12.9; P=.02 in the sham group). No difference between the HBO group and the sham group was observed (P=.70). Chamber sessions were well tolerated.
CONCLUSIONS AND RELEVANCE Among service members with persistent PCS, HBO showed no benefits over sham compressions. Both intervention groups demonstrated improved outcomes compared with PCS care alone. This finding suggests that the observed improvements were not oxygen mediated but may reflect nonspecific improvements related to placebo effects.
C1 [Miller, R. Scott; Fracisco, Susan] US Army Med Mat Dev Act, Ft Detrick, MD USA.
[Weaver, Lindell K.] Univ Utah, Sch Med, Dept Med, Salt Lake City, UT USA.
[Weaver, Lindell K.; Churchill, Susan; Deru, Kayla] LDS Hosp, Dept Hyperbar Med, Salt Lake City, UT USA.
[Bahraini, Nazanin; Brenner, Lisa A.] Univ Colorado, Aurora, CO USA.
[Bahraini, Nazanin; Brenner, Lisa A.] Mental Illness Res Educ & Clin Ctr, Vet Integrated Serv Network 19, Denver, CO USA.
[Price, Robert C.; Surrett, Gerald W.] Evans Army Community Hosp, Ft Carson, CO USA.
[Skiba, Virginia; Bartos, Corinna] Naval Hosp Camp Lejeune, Camp Lejeune, NC USA.
[Caviness, James; Ryan, Margaret] Naval Hosp Camp Pendleton, Camp Pendleton, CA USA.
[Mooney, Scott] Eisenhower Army Med Ctr, Ft Gordon, GA USA.
[Hetzell, Brian; Liu, Jun] Pharmaceut Prod Dev LLC, Wilmington, NC USA.
[Ricciardi, Richard] Def Ctr Excellence Psychol Hlth & Traumat Brain I, Silver Spring, MD USA.
[Close, Nicole C.] EmpiriStat Inc, Mt Airy, MD USA.
RP Miller, RS (reprint author), Uniformed Serv Univ Hlth Sci, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
EM robert.s.miller@us.army.mil
FU Defense Health Program
FX The HOPPS trial was funded by the Defense Health Program and was managed
by the US Army Medical Materiel Development Activity. The Naval Health
Research Center and Army Contracting Command contracted support
throughout this trial.
NR 38
TC 20
Z9 20
U1 1
U2 5
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-6106
EI 2168-6114
J9 JAMA INTERN MED
JI JAMA Intern. Med.
PD JAN
PY 2015
VL 175
IS 1
BP 43
EP 52
DI 10.1001/jamainternmed.2014.5479
PG 10
WC Medicine, General & Internal
SC General & Internal Medicine
GA AY1BM
UT WOS:000347328500013
PM 25401463
ER
PT J
AU Hoge, C
Jonas, WB
AF Hoge, CharlesW.
Jonas, Wayne B.
TI The Ritual of Hyperbaric Oxygen and Lessons for the Treatment of
Persistent Postconcussion Symptoms in Military Personnel
SO JAMA INTERNAL MEDICINE
LA English
DT Editorial Material
ID POSTTRAUMATIC-STRESS-DISORDER; COMBAT
C1 [Hoge, CharlesW.] Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Silver Spring, MD 20910 USA.
[Jonas, Wayne B.] Samueli Inst, Alexandria, VA USA.
RP Hoge, C (reprint author), Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Silver Spring, MD 20910 USA.
EM charles.hoge@us.army.mil
NR 7
TC 3
Z9 3
U1 0
U2 1
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-6106
EI 2168-6114
J9 JAMA INTERN MED
JI JAMA Intern. Med.
PD JAN
PY 2015
VL 175
IS 1
BP 53
EP 54
DI 10.1001/jamainternmed.2014.3375
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA AY1BM
UT WOS:000347328500014
PM 25401214
ER
PT J
AU Okulicz, JF
Le, TD
Agan, BK
Camargo, JF
Landrum, ML
Wright, E
Dolan, MJ
Ganesan, A
Ferguson, TM
Smith, DM
Richman, DD
Little, SJ
Clark, RA
He, WJ
Ahuja, SK
AF Okulicz, Jason F.
Le, Tuan D.
Agan, Brian K.
Camargo, Jose F.
Landrum, Michael L.
Wright, Edwina
Dolan, Matthew J.
Ganesan, Anuradha
Ferguson, Tomas M.
Smith, Davey M.
Richman, Douglas D.
Little, Susan J.
Clark, Robert A.
He, Weijing
Ahuja, Sunil K.
TI Influence of the Timing of Antiretroviral Therapy on the Potential for
Normalization of Immune Status in Human Immunodeficiency Virus
1-Infected Individuals
SO JAMA INTERNAL MEDICINE
LA English
DT Article
ID HIV-INFECTED PATIENTS; T-CELL COUNTS; CLINICAL-OUTCOMES; CD4 COUNT;
AIDS; RESTORATION; RESERVOIRS; INITIATION; RECOVERY; HAART
AB IMPORTANCE In individuals with human immunodeficiency virus 1 (HIV-1) infection who are receiving antiretroviral therapy (ART), factors that promote full immune recovery are not well characterized.
OBJECTIVE To investigate the influence of the timing of ART relative to HIV-1 infection on normalization of CD4(+) T-cell counts, AIDS risk, and immune function.
DESIGN, SETTING, AND PARTICIPANTS Participants in the observational US Military HIV Natural History Study with documented estimated dates of seroconversion (EDS) who achieved virologic suppression with ART were evaluated. Markers indicative of immune activation, dysfunction, and responsiveness were determined. Responses to hepatitis B virus (HBV) vaccine, an indicator of in vivo immune function, were also assessed. The timing of ART was indexed to the EDS and/or entry into the cohort. The CD4(+) counts in HIV-1-uninfected populations were surveyed.
MAIN OUTCOMES AND MEASURES Normalization of CD4(+) counts to 900 cells/mu L or higher, AIDS development, HBV vaccine response, as well as T-cell activation, dysfunction, and responsiveness.
RESULTS The median CD4(+) count in HIV-1-uninfected populations was approximately 900 cells/mu L. Among 1119 HIV-1-infected participants, CD4(+) normalization was achieved in 38.4% vs 28.3% of those initiating ART within 12 months vs after 12 months from the EDS (P=.001). Incrementally higher CD4(+) recovery (<500, 500-899, and >= 900 cells/mu L) was associated with stepwise decreases in AIDS risk and reversion of markers of immune activation, dysfunction, and responsiveness to levels approximating those found in HIV-1-uninfected persons. Participants with CD4(+) counts of 500 cells/mu L or higher at study entry (adjusted odds ratio [aOR], 2.00; 95% CI, 1.51-2.64; P<.001) or ART initiation (aOR, 4.08; 95% CI, 3.14-5.30; P<.001) had significantly increased CD4(+) normalization rates compared with other participants. However, even among individuals with a CD4(+) count of 500 cells/mu L or higher at both study entry and before ART, the odds of CD4(+) normalization were 80% lower in those initiating ART after 12 months from the EDS and study entry (aOR, 0.20; 95% CI, 0.07-0.53; P=001). Initiation of ART within 12 months of EDS vs later was associated with a significantly lower risk of AIDS (7.8% vs 15.3%; P=.002), reduced T-cell activation (percent CD4(+) HLA-DR+ effector memory T cells, 12.0% vs 15.6%; P=.03), and increased responsiveness to HBV vaccine (67.9% vs 50.9%; P=.07).
CONCLUSIONS AND RELEVANCE Deferral of ART beyond 12 months of the EDS diminishes the likelihood of restoring immunologic health in HIV-1-infected individuals.
C1 [Okulicz, Jason F.; Agan, Brian K.; Landrum, Michael L.; Ganesan, Anuradha; Ferguson, Tomas M.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA.
[Okulicz, Jason F.] San Antonio Mil Med Ctr, Infect Dis Serv, Ft Sam Houston, TX USA.
[Le, Tuan D.; Camargo, Jose F.; Clark, Robert A.; He, Weijing; Ahuja, Sunil K.] South Texas Vet Hlth Care Syst, Vet Affairs VA Res Ctr AIDS & HIV Infect 1, San Antonio, TX 78229 USA.
[Le, Tuan D.; Camargo, Jose F.; Clark, Robert A.; He, Weijing; Ahuja, Sunil K.] South Texas Vet Hlth Care Syst, Vet Affairs Ctr Personalized Med, San Antonio, TX 78229 USA.
[Le, Tuan D.; Camargo, Jose F.; Clark, Robert A.; He, Weijing; Ahuja, Sunil K.] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, San Antonio, TX 78229 USA.
[Agan, Brian K.] Henry M Jackson Fdn Adv Mil Med Inc, Bethesda, MD USA.
[Landrum, Michael L.] Brooke Army Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA.
[Wright, Edwina] Alfred Hosp, Dept Infect Dis, Melbourne, Vic, Australia.
[Wright, Edwina] Burnet Inst, Melbourne, Vic, Australia.
[Wright, Edwina] Monash Univ, Dept Infect Dis, Melbourne, Vic 3004, Australia.
[Dolan, Matthew J.] Mil Med Inc, Henry M Jackson Fdn Adv, Lackland AFB, TX USA.
[Ganesan, Anuradha] Walter Reed Natl Mil Med Ctr, Infect Dis Serv, Bethesda, MD USA.
[Ferguson, Tomas M.] Tripler Army Med Ctr, Infect Dis Serv, Honolulu, HI 96859 USA.
[Smith, Davey M.; Richman, Douglas D.; Little, Susan J.] Univ Calif San Diego, Dept Med, San Diego, CA 92103 USA.
[Smith, Davey M.; Richman, Douglas D.] Vet Affairs San Diego Healthcare Syst, San Diego, CA USA.
[Richman, Douglas D.] Univ Calif San Diego, Dept Pathol, San Diego, CA 92103 USA.
[Ahuja, Sunil K.] Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol & Immunol, San Antonio, TX 78229 USA.
RP Ahuja, SK (reprint author), South Texas Vet Hlth Care Syst, Vet Affairs VA Res Ctr AIDS & HIV Infect 1, 7400 Merton Minter Blvd,Room W200, San Antonio, TX 78229 USA.
EM ahujas@uthscsa.edu
OI Agan, Brian/0000-0002-5114-1669
FU Veterans Affairs (VA) Research Center [IP1 CX000875-01A1]; National
Institutes of Health (NIH) [R37AI046326]; Doris Duke Distinguished
Clinical Scientist Award; VA MERIT award; Elizabeth Glaser Pediatric
AIDS Foundation; Burroughs Wellcome Clinical Scientist Award; Max and
Minnie Tomerlin Voelcker Fund; NIH [UL1TR001120, DA034978, AI43638,
AI69432, MH62512, AI74621, MH097520, AI077304, AI007384, AI080193,
AI106039, AI096113]; VA Career Development Award-2; National Health and
Medical Research Council of Australia; Infectious Disease Clinical
Research Program (IDCRP); Uniformed Services University of the Health
Sciences [IDCRP-000-03]; National Institute of Allergy and Infectious
Diseases; International AIDS Vaccine Initiative [DMS0714991]
FX The work was supported by the Veterans Affairs (VA) Research Center for
AIDS and HIV Infection and VA Center for Personalized Medicine grant IP1
CX000875-01A1, National Institutes of Health (NIH) MERIT grant
R37AI046326, and the Doris Duke Distinguished Clinical Scientist Award
to Dr Ahuja. Dr Ahuja is also supported by a VA MERIT award, the
Elizabeth Glaser Pediatric AIDS Foundation, the Burroughs Wellcome
Clinical Scientist Award in Translational Research and the Senior
Scholar Award from the Max and Minnie Tomerlin Voelcker Fund. This work
was also supported by NIH grant UL1TR001120 (Clinical and Translational
Science Award). Dr Le was supported by a VA Career Development Award-2.
DrWright was supported by an Early Career Fellowship from the National
Health and Medical Research Council of Australia. Support for this work
was also provided in part by the Infectious Disease Clinical Research
Program (IDCRP), a Department of Defense program executed through the
Uniformed Services University of the Health Sciences (IDCRP-000-03).
This project has been funded in part with federal funds from the
National Institute of Allergy and Infectious Diseases, NIH, under
Inter-Agency Agreement Y1-AI-5072. Drs Smith, Richman, and Little were
supported by NIH grants DA034978, AI43638, AI69432, MH62512, AI74621,
MH097520, AI077304, AI007384, AI080193, AI106039, and AI096113 and the
International AIDS Vaccine Initiative grant DMS0714991.
NR 34
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PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-6106
EI 2168-6114
J9 JAMA INTERN MED
JI JAMA Intern. Med.
PD JAN
PY 2015
VL 175
IS 1
BP 88
EP 99
DI 10.1001/jamainternmed.2014.4010
PG 12
WC Medicine, General & Internal
SC General & Internal Medicine
GA AY1BM
UT WOS:000347328500019
PM 25419650
ER
PT J
AU Herrera, RA
AF Herrera, Ricardo A.
TI "[T]he zealous activity of Capt. Lee": Light-Horse Harry Lee and Petite
Guerre
SO JOURNAL OF MILITARY HISTORY
LA English
DT Article
AB The Continental Army entrusted many of its junior officers with a great degree of responsibility and autonomy. Captain Henry Lee's role in commanding a vital foraging operation in Delaware and Maryland for the Main Army at Valley Forge in February and March 1778 sheds light on the role of a company-grade officer within the broader framework of petite guerre. Lee demonstrated his ability at planning and executing autonomous operations and proved himself a capable, thoughtful, and energetic officer in an important, but overlooked expedition that reveals something of the important operational middle ground occupied by American company-grade light officers.
C1 US Army Command & Gen Staff Coll, Sch Adv Mil Studies, Ft Leavenworth, KS 66027 USA.
RP Herrera, RA (reprint author), US Army Command & Gen Staff Coll, Sch Adv Mil Studies, Ft Leavenworth, KS 66027 USA.
NR 129
TC 0
Z9 0
U1 0
U2 1
PU SOC MILITARY HISTORY
PI LEXINGTON
PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA
24450-1600 USA
SN 0899-3718
EI 1543-7795
J9 J MILITARY HIST
JI J. Mil. Hist.
PD JAN
PY 2015
VL 79
IS 1
BP 9
EP 36
PG 28
WC History
SC History
GA AY0ED
UT WOS:000347269600001
ER
PT J
AU Echevarria, AJ
AF Echevarria, Antdio J.
TI The Great War Dawning: Germany and its Army at the Start of World War I.
SO JOURNAL OF MILITARY HISTORY
LA English
DT Book Review
C1 [Echevarria, Antdio J.] US Army War Coll, Carlisle, PA 17013 USA.
RP Echevarria, AJ (reprint author), US Army War Coll, Carlisle, PA 17013 USA.
NR 1
TC 0
Z9 0
U1 0
U2 1
PU SOC MILITARY HISTORY
PI LEXINGTON
PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA
24450-1600 USA
SN 0899-3718
EI 1543-7795
J9 J MILITARY HIST
JI J. Mil. Hist.
PD JAN
PY 2015
VL 79
IS 1
BP 228
EP 229
PG 2
WC History
SC History
GA AY0ED
UT WOS:000347269600034
ER
PT J
AU Connelly, DB
AF Connelly, Donald B.
TI The Impact of the First World War on US Policymakers: American Strategic
and Foreign Policy Formulation, 1938-1942
SO JOURNAL OF MILITARY HISTORY
LA English
DT Book Review
C1 [Connelly, Donald B.] US Army Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA.
RP Connelly, DB (reprint author), US Army Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA.
NR 1
TC 0
Z9 0
U1 0
U2 1
PU SOC MILITARY HISTORY
PI LEXINGTON
PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA
24450-1600 USA
SN 0899-3718
EI 1543-7795
J9 J MILITARY HIST
JI J. Mil. Hist.
PD JAN
PY 2015
VL 79
IS 1
BP 246
EP 247
PG 2
WC History
SC History
GA AY0ED
UT WOS:000347269600048
ER
PT J
AU Fischer, JR
AF Fischer, Joseph R.
TI Dog Company: The Boys of Pointe die Hoc: The Rangers Who Accomplished
D-Day's Toughest Mission and Led the Way Across Europe
SO JOURNAL OF MILITARY HISTORY
LA English
DT Book Review
C1 [Fischer, Joseph R.] US Army Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA.
RP Fischer, JR (reprint author), US Army Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU SOC MILITARY HISTORY
PI LEXINGTON
PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA
24450-1600 USA
SN 0899-3718
EI 1543-7795
J9 J MILITARY HIST
JI J. Mil. Hist.
PD JAN
PY 2015
VL 79
IS 1
BP 252
EP 254
PG 3
WC History
SC History
GA AY0ED
UT WOS:000347269600053
ER
PT J
AU Rafuse, ES
AF Rafuse, Ethan S.
TI Misalliance: Ngo Dinh Diem, the United States, and the Fate of South
Vietnam
SO JOURNAL OF MILITARY HISTORY
LA English
DT Book Review
C1 [Rafuse, Ethan S.] US Army Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA.
RP Rafuse, ES (reprint author), US Army Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU SOC MILITARY HISTORY
PI LEXINGTON
PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA
24450-1600 USA
SN 0899-3718
EI 1543-7795
J9 J MILITARY HIST
JI J. Mil. Hist.
PD JAN
PY 2015
VL 79
IS 1
BP 259
EP 260
PG 2
WC History
SC History
GA AY0ED
UT WOS:000347269600057
ER
PT J
AU Cai, YY
Postnikova, EN
Bernbaum, JG
Yu, SQ
Mazur, S
Deiuliis, NM
Radoshitzky, SR
Lackemeyer, MG
McCluskey, A
Robinson, PJ
Haucke, V
Wahl-Jensen, V
Bailey, AL
Lauck, M
Friedrich, TC
O'Connor, DH
Goldberg, TL
Jahrling, PB
Kuhna, JH
AF Cai, Yingyun
Postnikova, Elena N.
Bernbaum, John G.
Yu, Shuiqing
Mazur, Steven
Deiuliis, Nicole M.
Radoshitzky, Sheli R.
Lackemeyer, Matthew G.
McCluskey, Adam
Robinson, Phillip J.
Haucke, Volker
Wahl-Jensen, Victoria
Bailey, Adam L.
Lauck, Michael
Friedrich, Thomas C.
O'Connor, David H.
Goldberg, Tony L.
Jahrling, Peter B.
Kuhna, Jens H.
TI Simian Hemorrhagic Fever Virus Cell Entry Is Dependent on CD163 and Uses
a Clathrin-Mediated Endocytosis-Like Pathway
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID RESPIRATORY SYNDROME VIRUS; EQUINE ARTERITIS VIRUS; HOST-CELLS; ENVELOPE
PROTEINS; VESICLE FORMATION; DISULFIDE BONDS; INFECTION; GENOME; RNA;
GLYCOPROTEIN
AB Simian hemorrhagic fever virus (SHFV) causes a severe and almost uniformly fatal viral hemorrhagic fever in Asian macaques but is thought to be nonpathogenic for humans. To date, the SHFV life cycle is almost completely uncharacterized on the molecular level. Here, we describe the first steps of the SHFV life cycle. Our experiments indicate that SHFV enters target cells by low-pH-dependent endocytosis. Dynamin inhibitors, chlorpromazine, methyl-beta-cyclodextrin, chloroquine, and concanamycin A dramatically reduced SHFV entry efficiency, whereas the macropinocytosis inhibitors EIPA, blebbistatin, and wortmannin and the caveolin-mediated endocytosis inhibitors nystatin and filipin III had no effect. Furthermore, overexpression and knockout study and electron microscopy results indicate that SHFV entry occurs by a dynamin-dependent clathrin-mediated endocytosis-like pathway. Experiments utilizing latrunculin B, cytochalasin B, and cytochalasin D indicate that SHFV does not hijack the actin polymerization pathway. Treatment of target cells with proteases (proteinase K, papain, alpha-chymotrypsin, and trypsin) abrogated entry, indicating that the SHFV cell surface receptor is a protein. Phospholipases A2 and D had no effect on SHFV entry. Finally, treatment of cells with antibodies targeting CD163, a cell surface molecule identified as an entry factor for the SHFV-related porcine reproductive and respiratory syndrome virus, diminished SHFV replication, identifying CD163 as an important SHFV entry component.
IMPORTANCE
Simian hemorrhagic fever virus (SHFV) causes highly lethal disease in Asian macaques resembling human illness caused by Ebola or Lassa virus. However, little is known about SHFV's ecology and molecular biology and the mechanism by which it causes disease. The results of this study shed light on how SHFV enters its target cells. Using electron microscopy and inhibitors for various cellular pathways, we demonstrate that SHFV invades cells by low-pH-dependent, actin-independent endocytosis, likely with the help of a cellular surface protein.
C1 [Cai, Yingyun; Postnikova, Elena N.; Bernbaum, John G.; Yu, Shuiqing; Mazur, Steven; Deiuliis, Nicole M.; Lackemeyer, Matthew G.; Wahl-Jensen, Victoria; Jahrling, Peter B.; Kuhna, Jens H.] NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD 21702 USA.
[Radoshitzky, Sheli R.] US Army, Med Res Inst Infect Dis, Frederick, MD USA.
[McCluskey, Adam] Univ Newcastle, Sch Environm & Life Sci, Dept Chem, Ctr Chem Biol, Callaghan, NSW 2308, Australia.
[Robinson, Phillip J.] Univ Sydney, Cell Signaling Unit, Childrens Med Res Inst, Sydney, NSW 2006, Australia.
[Haucke, Volker] Leibniz Inst Mol Pharmacol, Berlin, Germany.
[Bailey, Adam L.; Lauck, Michael; Friedrich, Thomas C.; O'Connor, David H.; Goldberg, Tony L.] Wisconsin Natl Primate Res Ctr, Madison, WI USA.
RP Kuhna, JH (reprint author), NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD 21702 USA.
EM kuhnjens@mail.nih.gov
RI Kuhn, Jens H./B-7615-2011; Robinson, Phillip/G-4008-2011;
OI Kuhn, Jens H./0000-0002-7800-6045; Robinson,
Phillip/0000-0002-7878-0313; Postnikova, Elena/0000-0002-0275-2148;
Deiuliis, Nicole/0000-0002-8923-0288; McCluskey,
Adam/0000-0001-7125-863X; Haucke, Volker/0000-0003-3119-6993
FU NIAID [HHSN272200700016I]
FX Y.C., E.N.P., J.G.B., V.W.-J., and J.H.K. performed this work as
employees of Tunnell Government Services, Inc., N.M.D. as an employee of
MRI Global, and M.G.L. as an employee of Lovelace Respiratory Research
Institute, all subcontractors of Battelle Memorial Institute, and S.Y.
as an emploee of Battelle Memorial Institute, all under Battelle's prime
contract with NIAID (contract no. HHSN272200700016I).
NR 73
TC 10
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U1 2
U2 17
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0022-538X
EI 1098-5514
J9 J VIROL
JI J. Virol.
PD JAN
PY 2015
VL 89
IS 1
BP 844
EP 856
DI 10.1128/JVI.02697-14
PG 13
WC Virology
SC Virology
GA AX8RL
UT WOS:000347176100071
PM 25355889
ER
PT J
AU Lesho, EP
AF Lesho, Emil P.
TI US Ebola Case: An Example of the Misuse of Antibiotics and a Reminder
for Better Stewardship
SO MAYO CLINIC PROCEEDINGS
LA English
DT Letter
C1 Walter Reed Army Inst Res, Silver Spring, MD USA.
RP Lesho, EP (reprint author), Walter Reed Army Inst Res, Silver Spring, MD USA.
NR 7
TC 1
Z9 1
U1 1
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0025-6196
EI 1942-5546
J9 MAYO CLIN PROC
JI Mayo Clin. Proc.
PD JAN
PY 2015
VL 90
IS 1
BP 161
EP 161
DI 10.1016/j.mayocp.2014.11.001
PG 1
WC Medicine, General & Internal
SC General & Internal Medicine
GA AY2ZW
UT WOS:000347455400024
PM 25572203
ER
PT J
AU Twenhafel, NA
Shaia, CI
Bunton, TE
Shamblin, JD
Wollen, SE
Pitt, LM
Sizemore, DR
Ogg, MM
Johnston, SC
AF Twenhafel, N. A.
Shaia, C. I.
Bunton, T. E.
Shamblin, J. D.
Wollen, S. E.
Pitt, L. M.
Sizemore, D. R.
Ogg, M. M.
Johnston, S. C.
TI Experimental Aerosolized Guinea Pig-Adapted Zaire Ebolavirus (Variant:
Mayinga) Causes Lethal Pneumonia in Guinea Pigs
SO VETERINARY PATHOLOGY
LA English
DT Article
DE aerosol; alveolar macrophages; animal model; ebolavirus; filovirus;
guinea pig; lungs; Mayinga
ID FILOVIRUS INFECTIONS; VIRUS VIRULENCE; MACAQUES
AB Eight guinea pigs were aerosolized with guinea pig-adapted Zaire ebolavirus (variant: Mayinga) and developed lethal interstitial pneumonia that was distinct from lesions described in guinea pigs challenged subcutaneously, nonhuman primates challenged by the aerosol route, and natural infection in humans. Guinea pigs succumbed with significant pathologic changes primarily restricted to the lungs. Intracytoplasmic inclusion bodies were observed in many alveolar macrophages. Perivasculitis was noted within the lungs. These changes are unlike those of documented subcutaneously challenged guinea pigs and aerosolized filoviral infections in nonhuman primates and human cases. Similar to findings in subcutaneously challenged guinea pigs, there were only mild lesions in the liver and spleen. To our knowledge, this is the first report of aerosol challenge of guinea pigs with guinea pig-adapted Zaire ebolavirus (variant: Mayinga). Before choosing this model for use in aerosolized ebolavirus studies, scientists and pathologists should be aware that aerosolized guinea pig-adapted Zaire ebolavirus (variant: Mayinga) causes lethal pneumonia in guinea pigs.
C1 [Twenhafel, N. A.; Shaia, C. I.; Bunton, T. E.; Shamblin, J. D.; Wollen, S. E.; Pitt, L. M.; Sizemore, D. R.; Ogg, M. M.; Johnston, S. C.] US Army Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
RP Twenhafel, NA (reprint author), US Army Med Res Inst Infect Dis, Div Pathol, 1425 Porter St, Ft Detrick, MD 21702 USA.
EM nancy.twenhafel@us.army.mil
NR 12
TC 9
Z9 9
U1 2
U2 4
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0300-9858
EI 1544-2217
J9 VET PATHOL
JI Vet. Pathol.
PD JAN
PY 2015
VL 52
IS 1
BP 21
EP 25
DI 10.1177/0300985814535612
PG 5
WC Pathology; Veterinary Sciences
SC Pathology; Veterinary Sciences
GA AY0QC
UT WOS:000347300600004
PM 24829285
ER
PT J
AU van Beers, PRM
Kouznetsova, VG
Geers, MGD
Tschopp, MA
McDowell, DL
AF van Beers, P. R. M.
Kouznetsova, V. G.
Geers, M. G. D.
Tschopp, M. A.
McDowell, D. L.
TI A multiscale model of grain boundary structure and energy: From
atomistics to a continuum description
SO ACTA MATERIALIA
LA English
DT Article
DE Grain boundary structure; Grain boundary energy; Multiscale;
Atomistic-to-continuum modeling
ID GRADIENT CRYSTAL PLASTICITY; TRANSMISSION ELECTRON-MICROSCOPY;
SYMMETRICAL TILT BOUNDARIES; CENTERED-CUBIC METALS; FRANK-BILBY
EQUATION; FCC METALS; UNIT MODEL; DISLOCATION-STRUCTURE; ELASTOPLASTIC
THEORY; DISCLINATION FIELDS
AB Grain boundaries play an important role in the mechanical and physical properties of polycrystalline metals. While continuum macroscale simulations are appropriate for modeling grain boundaries in coarse-grained materials, only atornistic simulations provide access to the details of the grain boundary (GB) structure and energy. Hence, a multiscale description is required to capture these GB details. The objective of this paper is to consolidate various approaches for characterizing grain boundaries in an effort to develop a multiscale model of the initial GB structure and energy. The technical approach is detailed using various < 100 >, < 110 > and < 111 > symmetric tilt grain boundaries in copper and aluminum. Characteristic features are: (i) GB energies obtained from atomistic simulations and boundary period vectors from crystallography, (ii) structural unit and dislocation descriptions of the GB structure and (iii) the Frank Bilby equation to determine the dislocation content. The proposed approach defines an intrinsic net defect density scalar that is used to accurately compute the GB energy for these GB systems. The significance of the present work is that the developed atomistic-to-continuum approach is suitable for realistically inserting the initial GB structure and energy into continuum level frameworks. (C) 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
C1 [van Beers, P. R. M.; Kouznetsova, V. G.; Geers, M. G. D.] Eindhoven Univ Technol, Dept Mech Engn, NL-5600 MB Eindhoven, Netherlands.
[Tschopp, M. A.] US Army, Ballist Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[McDowell, D. L.] Georgia Inst Technol, Woodruff Sch Mech Engn, Atlanta, GA 30332 USA.
RP Kouznetsova, VG (reprint author), Eindhoven Univ Technol, Dept Mech Engn, POB 513, NL-5600 MB Eindhoven, Netherlands.
EM v.g.kouznetsova@tue.nl
RI Kouznetsova, Varvara /D-4663-2016;
OI Kouznetsova, Varvara /0000-0003-0113-6471; Tschopp,
Mark/0000-0001-8471-5035
FU Dutch Technology Foundation STW; Ministry of Economic Affairs [10109]
FX This research is supported by the Dutch Technology Foundation STW, which
is the applied science division of NWO, and the Technology Program of
the Ministry of Economic Affairs under Project Nr. 10109. D.L.M. is
grateful for the support of the Carter N. Paden, Jr. Distinguished Chair
in Metals Processing.
NR 85
TC 14
Z9 14
U1 3
U2 45
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1359-6454
EI 1873-2453
J9 ACTA MATER
JI Acta Mater.
PD JAN 1
PY 2015
VL 82
BP 513
EP 529
DI 10.1016/j.actamat.2014.08.045
PG 17
WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical
Engineering
SC Materials Science; Metallurgy & Metallurgical Engineering
GA AX6FE
UT WOS:000347017800048
ER
PT J
AU Wu, FX
Lee, JT
Nitta, N
Kim, H
Borodin, O
Yushin, G
AF Wu, Feixiang
Lee, Jung Tae
Nitta, Naoki
Kim, Hyea
Borodin, Oleg
Yushin, Gleb
TI Lithium Iodide as a Promising Electrolyte Additive for Lithium-Sulfur
Batteries: Mechanisms of Performance Enhancement
SO ADVANCED MATERIALS
LA English
DT Article
ID LI-S BATTERIES; POLY(ETHYLENE OXIDE); CATHODE MATERIALS; ION BATTERIES;
COMPOSITE; GRAPHENE; DECOMPOSITION; TEMPERATURE; STABILITY; SPHERES
C1 [Wu, Feixiang; Lee, Jung Tae; Nitta, Naoki; Kim, Hyea; Yushin, Gleb] Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA.
[Wu, Feixiang] Cent S Univ, Sch Met & Environm, Changsha 410083, Peoples R China.
[Kim, Hyea] Sila Nanotechnol Inc, Atlanta, GA 30332 USA.
[Borodin, Oleg] Army Res Lab, Electrochem Branch, Adelphi, MD 20783 USA.
RP Yushin, G (reprint author), Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA.
EM yushin@gatech.edu
RI Yushin, Gleb/B-4529-2013; Borodin, Oleg/B-6855-2012
OI Yushin, Gleb/0000-0002-3274-9265; Borodin, Oleg/0000-0002-9428-5291
FU Army Research Office (ARO) [W911NF-12-1-0259]; China Scholarship Council
[201206370083]; National Science Foundation [DMR 0922776]
FX This work was partially supported by the Army Research Office (ARO grant
W911NF-12-1-0259). Wu fellowship was supported by China Scholarship
Council (No. 201206370083). The TEM used in this work was purchased
using support from the National Science Foundation (project DMR
0922776). The authors thank B. Zdyrko from Sila Nanotechnologies, Inc.
for helpful discussions.
NR 43
TC 47
Z9 48
U1 38
U2 297
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY
SN 0935-9648
EI 1521-4095
J9 ADV MATER
JI Adv. Mater.
PD JAN
PY 2015
VL 27
IS 1
BP 101
EP 108
DI 10.1002/adma.201404194
PG 8
WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied;
Physics, Condensed Matter
SC Chemistry; Science & Technology - Other Topics; Materials Science;
Physics
GA AX9RL
UT WOS:000347239600014
PM 25367318
ER
PT J
AU Hebert, JJ
Fritz, JM
Thackeray, A
Koppenhaver, SL
Teyhen, D
AF Hebert, Jeffrey J.
Fritz, Julie M.
Thackeray, Anne
Koppenhaver, Shane L.
Teyhen, Deydre
TI Early multimodal rehabilitation following lumbar disc surgery: a
randomised clinical trial comparing the effects of two exercise
programmes on clinical outcome and lumbar multifidus muscle function
SO BRITISH JOURNAL OF SPORTS MEDICINE
LA English
DT Article
ID LOW-BACK-PAIN; CROSS-SECTIONAL AREA; TRANSVERSUS ABDOMINIS;
POSTOPERATIVE MANAGEMENT; ACTIVITY RESTRICTIONS; IMPORTANT DIFFERENCE;
PARASPINAL MUSCLES; LOCAL DENERVATION; TRUNK MUSCLES; DRAWING-IN
AB Background The optimal components of postoperative exercise programmes following single-level lumbar discectomy have not been identified. Facilitating lumbar multifidus (LM) function after discectomy may improve postoperative recovery. The aim of this study was to compare the clinical and muscle function outcomes of patients randomised to receive early multimodal rehabilitation following lumbar discectomy consisting of exercises targeting specific trunk muscles including the LM or general trunk exercises.
Methods We included participants aged 18 to 60 years who were scheduled to undergo single-level lumbar discectomy. After two postoperative weeks, participants were randomly assigned to receive an 8-week multimodal exercise programme including either general or specific trunk exercises. The primary outcome was pain-related disability (Oswestry Index). Secondary outcomes included low back and leg pain intensity (0-10 numeric pain rating scale), global change, sciatica frequency, sciatica bothersomeness and LM function measured with real-time ultrasound imaging. Treatment effects 10 weeks and 6 months after surgery were estimated with linear mixed models.
Results 61 participants were randomised to receive a general trunk (n=32) or specific (n=29) exercise programme. There were no between-group differences in clinical or muscle function outcomes. Participants in both groups experienced improvements in most outcome measures.
Conclusions Following lumbar discectomy, multimodal rehabilitation programmes comprising specific or general trunk exercises have similar effects on clinical and muscle function outcomes. Local factors such as the individual patient characteristics identified by specific assessment findings, clinician expertise and patient preferences should direct therapy selection when considering the types of exercises tested in this trial for inclusion in rehabilitation programmes following lumbar disc surgery.
C1 [Hebert, Jeffrey J.; Koppenhaver, Shane L.] Murdoch Univ, Sch Psychol & Exercise Sci, Murdoch, WA 6150, Australia.
[Fritz, Julie M.; Thackeray, Anne] Univ Utah, Dept Phys Therapy, Salt Lake City, UT USA.
[Fritz, Julie M.] Intermt Healthcare, Salt Lake City, UT USA.
[Koppenhaver, Shane L.] US Army Baylor Univ Doctoral Program Phys Therapy, San Antonio, TX USA.
[Teyhen, Deydre] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA.
RP Hebert, JJ (reprint author), Murdoch Univ, Sch Psychol & Exercise Sci, 90 South St,ECL 4-008, Murdoch, WA 6150, Australia.
EM J.Hebert@Murdoch.edu.au
OI Thackeray, Anne/0000-0002-5496-7730; Hebert, Jeffrey/0000-0002-6959-325X
FU Orthopaedic Section of the American Physical Therapy Association
FX Orthopaedic Section of the American Physical Therapy Association.
NR 50
TC 3
Z9 4
U1 1
U2 3
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0306-3674
EI 1473-0480
J9 BRIT J SPORT MED
JI Br. J. Sports Med.
PD JAN
PY 2015
VL 49
IS 2
BP 100
EP U52
DI 10.1136/bjsports-2013-092402
PG 8
WC Sport Sciences
SC Sport Sciences
GA AX7OW
UT WOS:000347105900008
PM 24029724
ER
PT J
AU Mudhasani, R
Kota, KP
Retterer, C
Tran, JP
Tritsch, SR
Zamani, R
Whitehouse, CA
Bavari, S
AF Mudhasani, Rajini
Kota, Krishna P.
Retterer, Cary
Tran, Julie P.
Tritsch, Sarah R.
Zamani, Rouzbeh
Whitehouse, Chris A.
Bavari, Sina
TI High-Content Image-Based Screening of a Signal Transduction Pathway
Inhibitor Small-Molecule Library against Highly Pathogenic RNA Viruses
SO JOURNAL OF BIOMOLECULAR SCREENING
LA English
DT Article
DE antiviral drugs; high-content screening; cell-based assays; fluorescence
methods
ID RIFT-VALLEY FEVER; SPECTRUM ANTIVIRAL ACTIVITY; RIBAVIRIN; CHIKUNGUNYA;
INTERFERON; INFECTION; PROTEIN; ASSAYS; ALPHA
AB High-content image-based screening was developed as an approach to test a small-molecule library of compounds targeting signal transduction pathways for antiviral activity against multiple highly pathogenic RNA viruses. Of the 2843 compounds screened, 120 compounds exhibited 60% antiviral activity. Four compounds (E225-0969, E528-0039, G118-0778, and G544-0735), which were most active against Rift Valley fever virus (RVFV) and showed broad-spectrum antiviral activity, were selected for further evaluation for their concentration-response profile and cytotoxicity. These compounds did not show any visible cytotoxicity at the highest concentration of compound tested (200 mu M). All four of these compounds were more active than ribavirin against several viruses. One compound, E225-0969, had the lowest effective concentration (EC50 = 1.9-8.92 mu M) for all the viruses tested. This compound was 13- and 43-fold more inhibitory against RVFV and Chikungunya virus (CHIKV), respectively, than ribavirin. The highest selectivity index (>106.2) was for E225-0969 against CHIKV. Time-of-addition assays suggested that all four lead compounds targeted early steps in the viral life cycle (entry and/or replication) but not virus egress. Overall, this work demonstrates that high-content image analysis can be used to screen chemical libraries for new antivirals against highly pathogenic viruses.
C1 [Mudhasani, Rajini; Kota, Krishna P.; Retterer, Cary; Tran, Julie P.; Tritsch, Sarah R.; Zamani, Rouzbeh; Whitehouse, Chris A.; Bavari, Sina] US Army Med Res Inst Infect Dis, Therapeut Discovery Ctr, Mol & Translat Sci Div, Frederick, MD 21702 USA.
RP Bavari, S (reprint author), US Army Med Res Inst Infect Dis, Mol & Translat Sci Div, 1425 Porter St, Frederick, MD 21702 USA.
EM sina.bavari.civ@mail.mil
FU Defense Threat Reduction Agency (DTRA), Joint Science and Technology
Office for Chem Bio Defense
FX The authors disclosed receipt of the following financial support for the
research, authorship, and/or publication of this article: This study was
supported by funding from the Defense Threat Reduction Agency (DTRA),
Joint Science and Technology Office for Chem Bio Defense (JSTO-CBM.
THRV. 01.10. RD. 19), to S. B. Research by R. M. was supported in part
by an appointment to the Faculty Research Participation Program at the
U.S. Army Research and Materiel Command administered by the Oak Ridge
Institute for Science and Education through an interagency agreement
between the U.S. Department of Energy and the U.S. Army Medical Research
and Material Command. Opinions, interpretations, conclusions, and
recommendations are those of the authors and are not necessarily
endorsed by the U.S. Army or the U.S. government.
NR 24
TC 4
Z9 4
U1 2
U2 5
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1087-0571
EI 1552-454X
J9 J BIOMOL SCREEN
JI J. Biomol. Screen
PD JAN
PY 2015
VL 20
IS 1
SI SI
BP 141
EP 152
DI 10.1177/1087057114556253
PG 12
WC Biochemical Research Methods; Biotechnology & Applied Microbiology;
Chemistry, Analytical
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
Chemistry
GA AX4RE
UT WOS:000346918300016
PM 25342145
ER
PT J
AU Grujicic, M
Ramaswami, S
Snipes, JS
Yavari, R
Yen, CF
Cheeseman, BA
AF Grujicic, M.
Ramaswami, S.
Snipes, J. S.
Yavari, R.
Yen, C. -F.
Cheeseman, B. A.
TI Optimization of Gas Metal Arc Welding (GMAW) Process for Maximum
Ballistic Limit in MIL A46100 Steel Welded All-Metal Armor
SO JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
LA English
DT Article
DE ballistic limit; gas metal arc welding (GMAW) process optimization; MIL
A46100 armor-grade steel
ID MICROSTRUCTURE EVOLUTION; FAILURE MECHANISMS; HEAT-SOURCES; MODEL;
PREDICTION; PHASES; AA5083
AB Our recently developed multi-physics computational model for the conventional gas metal arc welding (GMAW) joining process has been upgraded with respect to its predictive capabilities regarding the process optimization for the attainment of maximum ballistic limit within the weld. The original model consists of six modules, each dedicated to handling a specific aspect of the GMAW process, i.e., (a) electro-dynamics of the welding gun; (b) radiation-/convection-controlled heat transfer from the electric arc to the workpiece and mass transfer from the filler metal consumable electrode to the weld; (c) prediction of the temporal evolution and the spatial distribution of thermal and mechanical fields within the weld region during the GMAW joining process; (d) the resulting temporal evolution and spatial distribution of the material microstructure throughout the weld region; (e) spatial distribution of the as-welded material mechanical properties; and (f) spatial distribution of the material ballistic limit. In the present work, the model is upgraded through the introduction of the seventh module in recognition of the fact that identification of the optimum GMAW process parameters relative to the attainment of the maximum ballistic limit within the weld region entails the use of advanced optimization and statistical sensitivity analysis methods and tools. The upgraded GMAW process model is next applied to the case of butt welding of MIL A46100 (a prototypical high-hardness armor-grade martensitic steel) workpieces using filler metal electrodes made of the same material. The predictions of the upgraded GMAW process model pertaining to the spatial distribution of the material microstructure and ballistic limit-controlling mechanical properties within the MIL A46100 butt weld are found to be consistent with general expectations and prior observations.
C1 [Grujicic, M.; Ramaswami, S.; Snipes, J. S.; Yavari, R.] Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA.
[Yen, C. -F.; Cheeseman, B. A.] Army Res Lab, Survivabil Mat Branch, Aberdeen Proving Ground, MD 21005 USA.
RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, 241 Engn Innovat Bldg, Clemson, SC 29634 USA.
EM gmica@clemson.edu
FU Army Research Office [W911NF-09-1-0513, W911NF-11-1-0207,
W911NF-11-1-0518]
FX The material presented in this paper is based on work supported by three
Army Research Office sponsored grants entitled "Multi-length Scale
Material Model Development for Armor-grade Composites" (Contract Number
W911NF-09-1-0513), "Friction Stir Welding Behavior of Selected
2000-series and 5000-series Aluminum Alloys" (Contract Number
W911NF-11-1-0207), and "Concept Validation and Optimization for a
Vent-based Mine-blast Mitigation System" (Contract Number
W911NF-11-1-0518). The authors are indebted to Dr. Ralph A. Anthenien,
Jr. and Dr. Bryan J. Glaz of ARO for their continuing support and
interest in the present work.
NR 47
TC 7
Z9 7
U1 1
U2 10
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1059-9495
EI 1544-1024
J9 J MATER ENG PERFORM
JI J. Mater. Eng. Perform.
PD JAN
PY 2015
VL 24
IS 1
BP 229
EP 244
DI 10.1007/s11665-014-1274-3
PG 16
WC Materials Science, Multidisciplinary
SC Materials Science
GA AX6KG
UT WOS:000347030600026
ER
PT J
AU Zubko, E
Videen, G
Shkuratov, Y
AF Zubko, Evgenij
Videen, Gorden
Shkuratov, Yuriy
TI Retrieval of dust-particle refractive index using the phenomenon of
negative polarization
SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER
LA English
DT Article
DE Negative polarization branch; Allende meteorite; Discrete dipole
approximation; Irregularly shaped particles
ID DISCRETE-DIPOLE APPROXIMATION; SCATTERING MATRICES; LIGHT-SCATTERING
AB We study the phenomenon of negative polarization in irregularly shaped agglomerated debris particles. We find that the location of the negative polarization minimum is unambiguously governed by Re(m). Furthermore, the amplitude of the negative polarization puts a strong constraint on the material absorption in target particles regardless of their real part of refractive index Re(m). The interrelation can be parameterized with a simple formula and it can be utilized in remote sensing. We apply our finding to laboratory optical measurements of Allende meteorite at lambda=0.633 mu m and estimate its complex refractive index to be m approximate to (1.68-1.83)+(0.01-0.02)i. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Zubko, Evgenij; Shkuratov, Yuriy] Kharkov Natl Univ, Inst Astron, UA-61022 Kharkov, Ukraine.
[Videen, Gorden] US Army Res Lab, RDRL CIE S, Adelphi, MD 20783 USA.
[Videen, Gorden] Space Sci Inst, Boulder, CO 80301 USA.
RP Zubko, E (reprint author), Kharkov Natl Univ, Inst Astron, 35 Sumskaya St, UA-61022 Kharkov, Ukraine.
EM evgenij.s.zubko@gmail.com
OI Zubko, Evgenij/0000-0001-9994-923X
FU NASA Lunar Advanced Science and Exploration Research Program
[NNX11AB25G]; NASA Outer Planets Research Program [NNX10AP93G]
FX This work was partially supported by NASA Lunar Advanced Science and
Exploration Research Program (Contract NNX11AB25G) and NASA Outer
Planets Research Program (Contract NNX10AP93G). We thank anonymous
referee for the constructive review.
NR 22
TC 2
Z9 2
U1 1
U2 9
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-4073
EI 1879-1352
J9 J QUANT SPECTROSC RA
JI J. Quant. Spectrosc. Radiat. Transf.
PD JAN
PY 2015
VL 151
BP 38
EP 42
DI 10.1016/j.jqsrt.2014.09.015
PG 5
WC Optics; Spectroscopy
SC Optics; Spectroscopy
GA AY0BM
UT WOS:000347263000006
ER
PT J
AU Wang, GX
Pandey, R
Karna, SP
AF Wang, Gaoxue
Pandey, Ravindra
Karna, Shashi P.
TI Phosphorene oxide: stability and electronic properties of a novel
two-dimensional material
SO NANOSCALE
LA English
DT Article
ID REDUCED GRAPHENE OXIDE; FIELD-EFFECT TRANSISTORS; TRANSPORT-PROPERTIES;
MONOLAYER; FILMS
AB Phosphorene, the monolayer form of (black) phosphorus, was recently exfoliated from its bulk counterpart. Phosphorene oxide, by analogy to graphene oxide, is expected to have novel chemical and electronic properties, and may provide an alternative route to the synthesis of phosphorene. In this research, the physical and chemical properties of phosphorene oxide including its formation by oxygen adsorption on the bare phosphorene was investigated. Analysis of the phonon dispersion curves finds stoichiometric and non-stoichiometric oxide configurations to be stable at ambient conditions, thus suggesting that the oxygen adsorption may not degrade the phosphorene. The nature of the band gap of the oxides depends on the degree of functionalization of phosphorene; an indirect gap is predicted for the non-stoichiometric configurations, whereas a direct gap is predicted for the stoichiometric oxide. Application of mechanical strain or an external electric field leads to tunability of the band gap of the phosphorene oxide. In contrast to the case of the bare phosphorene, dependence of the diode-like asymmetric current-voltage response on the degree of stoichiometry is predicted for the phosphorene oxide.
C1 [Wang, Gaoxue; Pandey, Ravindra] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA.
[Karna, Shashi P.] US Army, Res Lab, Weap & Mat Res Directorate, ATTN RDRL WM, Aberdeen Proving Ground, MD 21005 USA.
RP Pandey, R (reprint author), Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA.
EM gaoxuew@mtu.edu; pandey@mtu.edu; shashi.p.karna.civ@mail.mil
RI Wang, Gaoxue/C-9492-2017
OI Wang, Gaoxue/0000-0003-2539-3405
FU ARL [W911NF-14-2-0088]
FX The authors thank D.R. Banyai for providing his STM simulation code, and
are grateful to Dr S. Gowtham for his support with the installation of
the required software. RAMA and Superior high performance computing
clusters at the Michigan Technological University were used in obtaining
the results presented in this paper. Financial support from ARL
W911NF-14-2-0088 is acknowledged.
NR 44
TC 44
Z9 46
U1 21
U2 232
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 2040-3364
EI 2040-3372
J9 NANOSCALE
JI Nanoscale
PY 2015
VL 7
IS 2
BP 524
EP 531
DI 10.1039/c4nr05384b
PG 8
WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials
Science, Multidisciplinary; Physics, Applied
SC Chemistry; Science & Technology - Other Topics; Materials Science;
Physics
GA AX9TS
UT WOS:000347245500020
PM 25412501
ER
PT J
AU Nair, HS
Yadav, R
Adiga, S
Rao, SS
van Tol, J
Elizabeth, S
AF Nair, Harikrishnan S.
Yadav, Ruchika
Adiga, Shilpa
Rao, S. S.
van Tol, Johan
Elizabeth, Suja
TI Ferrimagnetism and magnetic phase separation in Nd1-xYxMnO3 studied by
magnetization and high frequency electron paramagnetic resonance
SO PHYSICA B-CONDENSED MATTER
LA English
DT Article
DE Ferrimagnetism; Magnetic phase separation; Manganites
ID NDMNO3; POLARIZATION; DIFFRACTION; MN
AB Ferrimagnetism and metamagnetic features tunable by composition are observed in the magnetic response of Nd1-xYxMnO3, for x=0.1-0.5. For all values of x in the series, the compound crystallizes in orthorhombic Pbnm space group similar to NdMnO3. Magnetization studies reveal a phase transition of the Mn-sublattice below T-N(Mn) approximate to 80 K for all compositions, which, decreases up on diluting the Nd-site with Yttrium. For x=0.35, ferrimagnetism is observed. At 5 K, metamagnetic transition is observed for all compositions x < 0.4. The evolution of magnetic ground states and appearance of ferrimagnetism in Nd1-xYxMnO3 can be accounted for by invoking the scenario of magnetic phase separation. The high frequency electron paramagnetic resonance measurements on x=0.4 sample, which is close to the critical composition for phase separation, revealed complex temperature dependent lineshapes clearly supporting the assumption of magnetic phase separation. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Nair, Harikrishnan S.; Yadav, Ruchika; Elizabeth, Suja] Indian Inst Sci, Dept Phys, Bangalore 560012, Karnataka, India.
[Adiga, Shilpa] Forschungszentrum Julich, Peter Grunberg Inst 4, Julich Ctr Neutron Sci 2, D-52425 Julich, Germany.
[Rao, S. S.] Army Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA.
[Rao, S. S.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA.
[van Tol, Johan] Florida State Univ, Natl High Magnet Field Lab, Ctr Interdisciplinary Magnet Resonance, Tallahassee, FL 32310 USA.
RP Nair, HS (reprint author), Indian Inst Sci, Dept Phys, Bangalore 560012, Karnataka, India.
EM krishnair1@gmail.com
FU Department of Science and Technology, India; national academy of
sciences (NAS), USA
FX S.E. wish to thank Department of Science and Technology, India for
financial support. S.S.R. acknowledges national academy of sciences
(NAS), USA for awarding national research council (NRC) postdoctoral
research associate fellowship.
NR 29
TC 0
Z9 0
U1 2
U2 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0921-4526
EI 1873-2135
J9 PHYSICA B
JI Physica B
PD JAN 1
PY 2015
VL 456
BP 108
EP 114
DI 10.1016/j.physb.2014.08.044
PG 7
WC Physics, Condensed Matter
SC Physics
GA AX3LP
UT WOS:000346841200020
ER
PT J
AU Sions, JM
Velasco, TO
Teyhen, DS
Hicks, GE
AF Sions, J. Megan
Velasco, Teonette O.
Teyhen, Deydre S.
Hicks, Gregory E.
TI Reliability of Ultrasound Imaging for the Assessment of Lumbar Multifidi
Thickness in Older Adults With Chronic Low Back Pain
SO JOURNAL OF GERIATRIC PHYSICAL THERAPY
LA English
DT Article
DE chronic low back pain; multifidus; ultrasound imaging
ID TRUNK MUSCLE COMPOSITION; CROSS-SECTIONAL AREA; BODY-COMPOSITION;
INTERRATER RELIABILITY; FUNCTIONAL-CAPACITY; HEALTHY-INDIVIDUALS;
EXTENSION ENDURANCE; ERECTOR SPINAE; LEG PAIN; STRENGTH
AB Background and Purpose: Ultrasound imaging (USI) has been shown to be a reliable measure for direct assessment of the lumbar multifidi among younger adults. However, given age- and chronic low back pain (CLBP)-related spinal changes, similar studies are needed before clinical use of USI among older adults with CLBP. The goals of this study were to evaluate intra-and interexaminer reliability for USI assessment of multifidi thickness at rest and during a contraction and to determine standard error of measurement values (SEMs) and minimal detectable change values (MDCs) among older adults with CLBP.
Methods: Thirty-one adults, aged 60 to 85 years, with CLBP were recruited. Two examiners performed USI assessments of multifidus thickness at rest and during a contralateral lower extremity lift. Intraclass correlation coefficients (ICCs) were used to estimate inter-and intraexaminer reliability. Additionally, SEMs and MDCs were calculated.
Results: All USI measurement techniques demonstrated excellent within-day, interexaminer procedural reliability (ICCs: 0.82-0.85) and good-to-excellent between-day, interexaminer procedural reliability (ICCs: 0.72-0.79). The SEMs ranged from 0.36 to 0.46 cm; MDCs ranged from 1.01 to 1.26 cm. Regardless of the measurement technique, examiner 1, the more experienced examiner, demonstrated lower SEMs and MDCs than examiner 2.
Discussion: Lower ICCs, greater SEMs, and greater MDCs for USI multifidus thickness assessment in older adults with CLBP, when compared with previously published, procedural reliability results for younger adults with and without low back pain, may indicate that imaging is more challenging in this patient population. Factors, such as examiner training and participant anthropometrics, may impact reliability.
Conclusions: Good-to-excellent intra-and interexaminer USI procedural reliability may provide clinicians a direct assessment technique for clinical evaluation of the lumbar multifidi in older adults with CLBP. SEMs and MDCs may allow for accurate interpretation of USI assessments in this population.
C1 [Sions, J. Megan; Velasco, Teonette O.; Hicks, Gregory E.] Univ Delaware, Dept Phys Therapy, Newark, DE 19713 USA.
[Teyhen, Deydre S.] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA.
RP Sions, JM (reprint author), Univ Delaware, 540 South Coll Ave,Suite 144A, Newark, DE 19713 USA.
EM megsions@udel.edu
FU Foundation for Physical Therapy PODS I/II; University of Delaware's
Office of Graduate Studies [R21HD057274]; NIA [R01AG041202-01]; NICHD
[R21 HD057274]
FX The work of Dr. Sions is supported in part by the Foundation for
Physical Therapy PODS I/II, the University of Delaware's Office of
Graduate Studies, R21HD057274 (NICHD), and R01AG041202-01 (NIA). The
work of Teonette Velasco and Dr. Hicks is supported in part by R21
HD057274 (NICHD) and R01AG041202-01 (NIA).
NR 47
TC 0
Z9 0
U1 2
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1539-8412
EI 2152-0895
J9 J GERIATR PHYS THER
JI J. Geriatr. Phys. Ther.
PD JAN-MAR
PY 2015
VL 38
IS 1
BP 33
EP 39
DI 10.1519/JPT.0000000000000021
PG 7
WC Geriatrics & Gerontology; Rehabilitation
SC Geriatrics & Gerontology; Rehabilitation
GA AX2HA
UT WOS:000346762900004
PM 24743751
ER
PT J
AU Hire, JM
Jacobs, JM
Bundy, JV
DeVine, JG
AF Hire, Justin M.
Jacobs, Jeremy M.
Bundy, Justin V.
DeVine, John G.
TI A modified Bohlman technique using a novel implant for treatment of
high-grade spondylolisthesis
SO JOURNAL OF NEUROSURGERY-SPINE
LA English
DT Article
DE modified Bohlman technique; AxiaLif TranS1 system; spondylolisthesis;
spinal instrumentation; lumbar
ID ISTHMIC SPONDYLOLISTHESIS; IN-SITU; REDUCTION; FUSION; INSTRUMENTATION;
SPONDYLOLYSIS; DECOMPRESSION; ADOLESCENTS; CHILDREN
AB Several surgical options for managing high-grade spondylolisthesis have been described in the literature and range from posterior-only in situ fusion to circumferential fusion with complete reduction of the dislocation. The level of evidence supporting any one technique is weak, and to date there is no Level I or II evidence supporting any current surgical treatment option. Techniques have evolved as implant technology has advanced and surgeons have gained experience with deformity correction. Still, the paucity of cases at any one institution limits the ability to perform clinical studies in a prospective and randomized fashion. To the authors' knowledge, the use of the AxiaLif bolt in a modified Bohlman technique has not been described. In the setting of a case of symptomatic high-grade spondylolisthesis refractory to nonoperative management, the authors describe a modified Bohlman technique in which they used the AxiaLif bolt rather than the fibula graft that was originally described. They then supplemented this with pedicle screw instrumentation and an iliac crest autograft. At the 2-year follow-up exam, the patient exhibited relief of his preoperative back and leg pain and he had returned to all activities. The latest radiographs demonstrated successful fusion. A single-stage, posterior instrumented fusion in which the AxiaLif bolt is used in lieu of fibula autograft or allograft in a modified,Bohlman technique is technically less demanding, does not have the morbidity associated with harvesting a fibula autograft, and carries no risk of disease transmission associated with the use of allograft.
C1 [Hire, Justin M.; Jacobs, Jeremy M.; DeVine, John G.] Dwight D Eisenhower Army Med Ctr, Dept Orthopaed & Rehabil, Ft Gordon, GA 30905 USA.
[Bundy, Justin V.] Doctors Hosp, Augusta, GA USA.
RP Bundy, JV (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Orthopaed & Rehabil, 300 Hosp Rd, Ft Gordon, GA 30905 USA.
EM justin.m.hire.mil@mail.mil
NR 16
TC 1
Z9 1
U1 1
U2 3
PU AMER ASSOC NEUROLOGICAL SURGEONS
PI ROLLING MEADOWS
PA 5550 MEADOWBROOK DRIVE, ROLLING MEADOWS, IL 60008 USA
SN 1547-5654
EI 1547-5646
J9 J NEUROSURG-SPINE
JI J. Neurosurg.-Spine
PD JAN
PY 2015
VL 22
IS 1
BP 80
EP 83
DI 10.3171/2014.10.SPINE14138
PG 4
WC Clinical Neurology; Surgery
SC Neurosciences & Neurology; Surgery
GA AX3CA
UT WOS:000346817000013
PM 25380540
ER
PT J
AU Long, KN
Houston, R
Watson, JDB
Morrison, JJ
Rasmussen, TE
Propper, BW
Arthurs, ZM
AF Long, Kira N.
Houston, Robert
Watson, J. Devin B.
Morrison, Jonathan J.
Rasmussen, Todd E.
Propper, Brandon W.
Arthurs, Zachary M.
TI Functional Outcome after Resuscitative Endovascular Balloon Occlusion of
the Aorta of the Proximal and Distal Thoracic Aorta in a Swine Model of
Controlled Hemorrhage
SO ANNALS OF VASCULAR SURGERY
LA English
DT Article
ID NONCOMPRESSIBLE TORSO HEMORRHAGE; THORACOTOMY; SHOCK; STRATEGIES;
INJURY; DEATH
AB Background: Noncompressible torso hemorrhage remains an ongoing problem for both military and civilian trauma. Resuscitative endovascular balloon occlusion of the aorta (REBOA) has been characterized as a potentially life-saving maneuver. The objective of this study was to determine the functional outcomes, paraplegia rates, and survival of 60-min balloon occlusion in the proximal and distal thoracic aorta in a porcine model of controlled hemorrhage.
Methods: Swine (Sus scrofa, 70-110 kg) were subjected to class IV hemorrhagic shock and underwent 60 min of REBOA. Devices were introduced from the left carotid artery and positioned in the thoracic aorta in either the proximal location (pREBOA [n = 8]; just past takeoff of left subclavian artery) or distal location (dREBOA [n = 8]; just above diaphragm). After REBOA, animals were resuscitated with whole blood, crystalloid, and vasopressors before a 4-day postoperative period. End points included evidence of spinal cord ischemia (clinical examination, Tarlov gait score, bowel and bladder dysfunction, and histopathology), gross ischemia-reperfusion injury (clinical examination and histopathology), and mortality.
Results: The overall mortality was similar between pREBOA and dREBOA groups at 37.5% (n = 3). Spinal corderelated mortality was 12.5% for both pREBOA and dREBOA groups. Spinal cord symptoms without death were present in 12.5% of pREBOA and dREBOA groups. Average gait scores improved throughout the postoperative period.
Conclusions: REBOA placement in the proximal or distal thoracic aorta does not alter mortality or paraplegia rates as compared with controlled hemorrhage alone. Functional recovery improves in the presence or the absence of REBOA, although at a slower rate after REBOA as compared with negative controls. Additional research is required to determine the ideal placement of REBOA in an uncontrolled hemorrhage model to achieve use compatible with survival outcomes and quality of life.
C1 [Long, Kira N.; Rasmussen, Todd E.] 59th Med Wing, San Antonio, TX USA.
[Long, Kira N.] Geneva Fdn, Tacoma, WA USA.
[Long, Kira N.] Tulane Univ, Dept Surg, New Orleans, LA 70118 USA.
[Houston, Robert; Watson, J. Devin B.; Propper, Brandon W.; Arthurs, Zachary M.] San Antonio Mil Med Ctr, Div Vasc Surg, San Antonio, TX USA.
[Morrison, Jonathan J.] Royal Ctr Def Med, Birmingham, W Midlands, England.
[Rasmussen, Todd E.] US Army Inst Surg Res, San Antonio, TX USA.
RP Long, KN (reprint author), Tulane Univ, Dept Surg, 1430 Tulane Ave,SL-22, New Orleans, LA 70112 USA.
EM klong2@tulane.edu
OI Morrison, Jonathan/0000-0001-7462-8456
NR 16
TC 7
Z9 7
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0890-5096
EI 1615-5947
J9 ANN VASC SURG
JI Ann. Vasc. Surg.
PD JAN
PY 2015
VL 29
IS 1
BP 114
EP 121
DI 10.1016/j.avsg.2014.10.004
PG 8
WC Surgery; Peripheral Vascular Disease
SC Surgery; Cardiovascular System & Cardiology
GA AW4GS
UT WOS:000346239900018
PM 25449984
ER
PT J
AU Stynoski, P
Mondal, P
Marsh, C
AF Stynoski, Peter
Mondal, Paramita
Marsh, Charles
TI Effects of silica additives on fracture properties of carbon nanotube
and carbon fiber reinforced Portland cement mortar
SO CEMENT & CONCRETE COMPOSITES
LA English
DT Article
DE Portland cement; Fracture toughness; Carbon nanotube; Carbon fiber;
Silica fume; Interfacial transition zone
ID COMPOSITE PVA-ECC; MECHANICAL-PROPERTIES; CONCRETE; MICROSTRUCTURE;
DISPERSION; INTERFACE; BEHAVIOR; MATRIX
AB Fiber reinforcements provide many benefits to cementitious composites, including reduction of crack widths and increases in ductility. However, the interfacial transition zone between fibers and hydrated cement can contain a high proportion of calcium hydroxide and porosity. With their high moduli of elasticity, carbon nanotubes and carbon fibers could provide substantial mechanical reinforcement at multiple length scales, but only if their bond to the matrix can be controlled. Surface treatments of fibers and addition of supplemental materials in the matrix can influence both the mechanical interaction at the interface and the dispersion of these relatively small reinforcements. We performed a broad study of Portland cement mortar mixtures containing silica fume, plain or silica-functionalized carbon nanotubes, and carbon fibers to characterize changes in fracture properties. The early age hydration kinetics of cement pastes containing carbon nanotubes were compared using isothermal calorimetry. Early age fracture surfaces of cement pastes containing carbon fibers were observed using a scanning electron microscope. The notched beam test method of the Two Parameter Fracture Model was used to determine the fracture properties of each mix. We observed that silica fume and silica functional groups improved the fracture performance of mixtures containing carbon nanotubes and carbon fibers. Further optimization of dosage, size, and interface strength is required to fully utilize carbon nanotubes in cementitious composites. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Stynoski, Peter; Mondal, Paramita] Univ Illinois, Dept Civil & Environm Engn, Urbana, IL 61801 USA.
[Stynoski, Peter; Marsh, Charles] US Army Construct Engn Res Lab, Champaign, IL 61822 USA.
[Marsh, Charles] Univ Illinois, Dept Nucl Plasma & Radiol Engn, Urbana, IL 61801 USA.
RP Stynoski, P (reprint author), Univ Illinois, Dept Civil & Environm Engn, 205 N Mathews Ave, Urbana, IL 61801 USA.
EM pstynos2@illinois.edu; pmondal@illinois.edu;
charles.p.marsh@usace.army.mil
FU US Army Corps of Engineers Engineer Research and Development Center
(ERDC)
FX The authors gratefully acknowledge the assistance of Mr. Erik Wotring,
University of Illinois at Urbana-Champaign, in the laboratory. We also
appreciate the valuable input of Prof. Amanda Bordelon, University of
Utah, and Dr. David Farrow, University of Illinois at Urbana-Champaign,
while configuring the load frame and test protocol. This research is
supported in part by the Section 219 authority of the US Army Corps of
Engineers Engineer Research and Development Center (ERDC) under the
projects, "Effects of Grain Boundaries on Ceramic Properties," and,
"Advancing the Development of the Super Ceramic and Associated
Technologies."
NR 33
TC 8
Z9 8
U1 7
U2 45
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0958-9465
EI 1873-393X
J9 CEMENT CONCRETE COMP
JI Cem. Concr. Compos.
PD JAN
PY 2015
VL 55
BP 232
EP 240
DI 10.1016/j.cemconcomp.2014.08.005
PG 9
WC Construction & Building Technology; Materials Science, Composites
SC Construction & Building Technology; Materials Science
GA AW4AS
UT WOS:000346224600026
ER
PT J
AU O'Brien, DJ
Baechle, DM
Yurchak, OB
Wetzel, ED
AF O'Brien, D. J.
Baechle, D. M.
Yurchak, O. B.
Wetzel, E. D.
TI Effect of processing conditions and electrode characteristics on the
electrical properties of structural composite capacitors
SO COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
LA English
DT Article
DE Smart materials; Hybrid; Electrical properties; Cure
ID ENERGY-STORAGE; DIELECTRIC-BREAKDOWN; FILM CAPACITOR; CARBON-FIBERS;
PERFORMANCE; POLYMERS; VOLTAGE; DESIGN; FIELD
AB Structural capacitors are manufactured from glass fabric/epoxy prepreg dielectrics and metalized polymer film electrodes. The electrical breakdown strengths of these multifunctional materials are investigated across a wide range of electrode constructions and processing parameters. The results show that electrode selection and materials processing have a significant impact on the energy that the device can store. Also, this careful consideration of processing parameters and electrode construction has led to the development of a structural capacitor with an energy density exceeding 0.90 J/cm(3), the highest yet reported. Published by Elsevier Ltd.
C1 [O'Brien, D. J.; Baechle, D. M.; Yurchak, O. B.; Wetzel, E. D.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
RP O'Brien, DJ (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
EM daniel.j.obrien58.civ@mail.mil
NR 42
TC 2
Z9 2
U1 3
U2 27
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1359-835X
EI 1878-5840
J9 COMPOS PART A-APPL S
JI Compos. Pt. A-Appl. Sci. Manuf.
PD JAN
PY 2015
VL 68
BP 47
EP 55
DI 10.1016/j.compositesa.2014.09.003
PG 9
WC Engineering, Manufacturing; Materials Science, Composites
SC Engineering; Materials Science
GA AW7OE
UT WOS:000346452400006
ER
PT J
AU Keawcharoen, J
Techangamsuwan, S
Ponpornpisit, A
Lombardini, ED
Patchimasiri, T
Pirarat, N
AF Keawcharoen, J.
Techangamsuwan, S.
Ponpornpisit, A.
Lombardini, E. D.
Patchimasiri, T.
Pirarat, N.
TI Genetic characterization of a betanodavirus isolated from a clinical
disease outbreak in farm-raised tilapia Oreochromis niloticus (L.) in
Thailand
SO JOURNAL OF FISH DISEASES
LA English
DT Article
DE betanodavirus; farm-raised tilapia; Genetic characteristic; Thailand
ID NERVOUS-NECROSIS-VIRUS; HALIBUT HIPPOGLOSSUS-HIPPOGLOSSUS; GROUPER
EPINEPHELUS-AKAARA; FRESH-WATER; NODAVIRUS INFECTION; COAT PROTEIN; FISH
NODAVIRUS; CAPSID PROTEIN; MARINE FISH; ENCEPHALOPATHY
AB Betanodavirus infection was diagnosed in larvae of farm-raised tilapia Oreochromisniloticus (L.), in central Thailand. Extensive vacuolar degeneration and neuronal necrosis were observed in histological sections with positive immunohistochemical staining for betanodavirus. Molecular phylogenetic analysis was performed based on the nucleotide sequences (1333 bases) of the capsid protein gene. The virus strain was highly homologous (93.07-93.88%) and closely related to red-spotted grouper nervous necrosis virus (RGNNV).
C1 [Keawcharoen, J.] Chulalongkorn Univ, Dept Vet Microbiol, Fac Vet Sci, Bangkok 10330, Thailand.
[Techangamsuwan, S.; Pirarat, N.] Chulalongkorn Univ, Dept Pathol, Fac Vet Sci, Bangkok 10330, Thailand.
[Ponpornpisit, A.] Chulalongkorn Univ, Dept Vet Med, Fac Vet Sci, Bangkok 10330, Thailand.
[Lombardini, E. D.] Armed Forces Res Inst Med Sci, Div Comparat Pathol, Dept Vet Med, Bangkok, Thailand.
[Lombardini, E. D.] Armed Forces Res Inst Med Sci, Div Res, Dept Vet Med, Bangkok, Thailand.
[Patchimasiri, T.] Natl Inst Anim Hlth, Pathol Sect, Bangkok, Thailand.
RP Pirarat, N (reprint author), Chulalongkorn Univ, Dept Pathol, Fac Vet Sci, Bangkok 10330, Thailand.
EM piraratnop@hotmail.com
NR 32
TC 4
Z9 6
U1 2
U2 14
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0140-7775
EI 1365-2761
J9 J FISH DIS
JI J. Fish Dis.
PD JAN
PY 2015
VL 38
IS 1
BP 49
EP 54
DI 10.1111/jfd.12200
PG 6
WC Fisheries; Marine & Freshwater Biology; Veterinary Sciences
SC Fisheries; Marine & Freshwater Biology; Veterinary Sciences
GA AW9MC
UT WOS:000346580400006
PM 24164433
ER
PT J
AU Levy, J
Ernat, J
Song, D
Cook, JB
Judd, D
Shaha, S
AF Levy, Jeffrey
Ernat, Justin
Song, Daniel
Cook, Jay B.
Judd, Daniel
Shaha, Steven
TI Outcomes of Long-arm Casting Versus Double-Sugar-Tong Splinting of Acute
Pediatric Distal Forearm Fractures
SO JOURNAL OF PEDIATRIC ORTHOPAEDICS
LA English
DT Article
DE Level II-prospective; comparative study
ID EPIPHYSEAL PLATES; RADIAL FRACTURES; PLASTER CASTS; RISK-FACTORS;
CHILDREN; REDISPLACEMENT; ORIENTATION; 3RD
AB Introduction: The traditional treatment after closed reduction of distal radius (DR) and distal both bone (DBB) forearm fractures has been application of a long-arm cast (LAC) or a short-arm cast (SAC). Splinting is another option that avoids the potential complications associated with casting. The purpose of this study is to evaluate the maintenance of reduction of DR or DBB fractures placed in a double-sugar-tong splint (DSTS) compared with a LAC in a pediatric population.
Methods: This is an IRB-approved, prospective, randomized trial. Patients aged 4 to 12 years with DR or DBB fractures treated at a single institution between 2010 and 2012 were enrolled. After reduction, fractures were placed into either a LAC or a DSTS. Radiographs were reviewed at initial injury, postreduction, and at set intervals for angulation, displacement, and apposition, as well as cast index and 3-point index. The DSTS was overwrapped into a cast after week 1. The immobilization device was changed to a SAC at week 4 or 6. Total duration of immobilization was 6 to 8 weeks.
Results: Seventy-one patients were enrolled with 37 in the LAC and 34 in the DSTS. Average age was 8.73 years (range, 4 to 12) with 43 being males. There were 28 isolated DR and 43 DBB fractures. There were no week-to-week differences between the 2 groups in regards to sagittal alignment, coronal alignment, apposition, or displacement. Sagittal alignment at immediate postreduction and week 2 showed that the DSTS was slightly better (average 2.0 vs. 5.0 degrees, respectively, P = 0.04). For the entire treatment period there was an increased risk of loss of reduction of >= 10 degrees in the LAC group versus the DSTS group (7 patients vs. 2 patients, respectively, P = 0.0001), and of meeting the criteria for remanipulation (10 patients vs. 5 patients, respectively, P = 0.01). At cast removal, there was no difference between groups.
Conclusions: Although there were significant differences between the 2 groups with regards to risk of reduction loss, the DSTS and LAC were comparable in maintenance of reduction at the time of cast removal. Both the DSTS and LAC are appropriate immobilization devices for these pediatric fractures.
Level of Evidence: Level II-prospective, comparative study.
C1 [Levy, Jeffrey; Ernat, Justin; Song, Daniel; Cook, Jay B.] Tripler Army Med Ctr, Dept Orthopaed Surg, Honolulu, HI 96859 USA.
[Judd, Daniel] St Lukes, Sun Valley Sports Med, Hailey, ID USA.
[Shaha, Steven] Univ Utah, Draper, UT USA.
RP Ernat, J (reprint author), Tripler Army Med Ctr, Dept Orthopaed Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM justin.ernat@gmail.com
NR 20
TC 0
Z9 0
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0271-6798
EI 1539-2570
J9 J PEDIATR ORTHOPED
JI J. Pediatr. Orthop.
PD JAN
PY 2015
VL 35
IS 1
BP 11
EP 17
PG 7
WC Orthopedics; Pediatrics
SC Orthopedics; Pediatrics
GA AW3MC
UT WOS:000346189800004
PM 24787302
ER
PT J
AU Percival, TJ
Patel, S
Markov, NP
Morrison, JJ
Spencer, JR
Ross, JD
Rasmussen, TE
AF Percival, Thomas J.
Patel, Shimul
Markov, Nickolay P.
Morrison, Jonathan J.
Spencer, Jerry R.
Ross, James D.
Rasmussen, Todd E.
TI Prophylactic fasciotomy in a porcine model of extremity trauma
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE Vascular injury; Extremity; Ischemia reperfusion; Recovery;
Neuromuscular; Functional; Fasciotomy
ID VASCULAR INJURY; COMPARTMENT SYNDROME; OUTCOME ANALYSIS; COMPLICATIONS;
REPERFUSION; MANAGEMENT; ISCHEMIA
AB Background: Extremity injury, with concomitant hemorrhagic shock, can result in ischemia-reperfusion injury and the formation of compartment syndrome requiring fasciotomy. As the benefit of prophylactic fasciotomy is unclear, the objective of this study is to determine the functional recovery of an ischemic limb with hemorrhagic shock after prophylactic fasciotomy.
Material and methods: Yorkshire swine underwent 35% blood volume hemorrhage, followed by 1, 3, and 6 h of ischemia (n = 17; 1HR, 3HR, and 6HR) via iliac artery occlusion followed by repair and reperfusion. A second cohort (n = 18) underwent fasciotomy of the anterior compartment of the hind limb following vascular repair (1HR-F, 3HR-F, and 6HR-F). Compartment pressures, measures of electromyographic (EMG) recovery, and a validated gait score (modified Tarlov) were performed throughout a 14-d survival period.
Results: Increasing ischemic intervals resulted in incremental increases in compartment pressure (P < 0.05), although the mean did not exceed 30 mm Hg. EMG studies did not show a significant improvement comparing the 3HR with 6HR groups. There was a significant improvement in the EMG studies within the 3HR-F, when compared with 6HR-F. There was a trend toward sensory improvement between the 3HR-F and 3HR groups. However, this did not translate to a difference in functional outcome as measured by the Tarlov gait score.
Conclusions: Within this swine model of hemorrhagic shock and hind limb ischemia, the use of prophylactic fasciotomies did not improve functional outcome. Published by Elsevier Inc.
C1 [Percival, Thomas J.; Markov, Nickolay P.; Spencer, Jerry R.; Ross, James D.; Rasmussen, Todd E.] Joint Base San Antonio, Med Wing 59, San Antonio, TX USA.
[Percival, Thomas J.; Patel, Shimul; Markov, Nickolay P.; Morrison, Jonathan J.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Morrison, Jonathan J.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England.
[Morrison, Jonathan J.] Glasgow Royal Infirm, Acad Surg Unit, Glasgow G4 0SF, Lanark, Scotland.
[Rasmussen, Todd E.] US Combat Casualty Care Res Program, Ft Detrick, MD 21702 USA.
[Rasmussen, Todd E.] Uniformed Serv Univ Hlth Sci, Bethesda, MD USA.
RP Rasmussen, TE (reprint author), US Combat Casualty Care Res Program, 722 Doughten St,Room 3, Ft Detrick, MD 21702 USA.
EM todd.e.rasmussen.mil@mail.mil
OI Morrison, Jonathan/0000-0001-7462-8456
FU United States Air Force
FX Authors' contributions: T.E.R. and T.J.P. jointly conceived the study
and obtained funding from the United States Air Force. T.J.P., S.P.,
N.P.M., and J.R.S. executed the experiments. J.R.S. managed the material
and personnel needs within the laboratory and managed the financial
aspects of the protocol. T.E.R., T.J.P., J.J.M., and J.R.S. analyzed and
interpreted the data and wrote the article. J.J.M. and T.J.P. revised
the article. J.J.M. administered the submission process.
NR 20
TC 0
Z9 0
U1 0
U2 1
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD JAN
PY 2015
VL 193
IS 1
BP 449
EP 457
DI 10.1016/j.jss.2014.07.016
PG 9
WC Surgery
SC Surgery
GA AW4HH
UT WOS:000346241300058
PM 25124897
ER
PT J
AU Bianchini, A
Gonzalez, CR
Barker, WR
AF Bianchini, Alessandra
Gonzalez, Carlos R.
Barker, Walter R.
TI Recommendations for the Minimum Thickness of Concrete Pavements
Supporting F-15 and C-17 Aircrafts
SO JOURNAL OF TRANSPORTATION ENGINEERING
LA English
DT Article
DE Rigid pavements; Minimum thickness; Strain gauges; Full-scale pavement
test section; Heavy aircraft pavement
AB The procedure for the design of military rigid airfield pavements contained in the Unified Facilities Criteria 3-260-02 gives the minimum thickness of airfield concrete pavements as 152mm (6in.). The introduction of the C-17 aircraft and the requirement of dowel bars as a joint load transfer mechanism bring into question the validity of the 152-mm (6-in.) minimum thickness. With the objective of updating such minimum thickness criteria, a full-scale test section was constructed and trafficked with loads simulating F-15, B-52, and C-17 aircraft landing gear. Evaluation of the test section performance and analysis of the strain data supported a U.S. Army Engineer Research and Development Center team recommendations that the minimum pavement thickness be increased to 203mm (8in.) for any doweled airfield pavement and that the minimum thickness of 279mm (11in.) should be required for those pavements supporting C-17 aircraft.
C1 [Bianchini, Alessandra] Airbase Recovery & Acquisit SME, Tyndall AFB, FL 32403 USA.
[Bianchini, Alessandra; Gonzalez, Carlos R.] US Army, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Bianchini, A (reprint author), Airbase Recovery & Acquisit SME, AFCEC CXAI 139 Barnes Dr,Ste 2, Tyndall AFB, FL 32403 USA.
EM alessandra.bianchini@us.af.mil; carlos.r.gonzalez@usace.army.mil;
wrbarker37@gmail.com
NR 5
TC 0
Z9 0
U1 2
U2 9
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0733-947X
EI 1943-5436
J9 J TRANSP ENG
JI J. Transp. Eng.
PD JAN
PY 2015
VL 141
IS 1
AR 06014002
DI 10.1061/(ASCE)TE.1943-5436.0000732
PG 6
WC Engineering, Civil; Transportation Science & Technology
SC Engineering; Transportation
GA AW5WQ
UT WOS:000346342200010
ER
PT J
AU Voiry, D
Goswami, A
Kappera, R
Silva, CDCE
Kaplan, D
Fujita, T
Chen, MW
Asefa, T
Chhowalla, M
AF Voiry, Damien
Goswami, Anandarup
Kappera, Rajesh
Castro e Silva, Cecilia de Carvalho
Kaplan, Daniel
Fujita, Takeshi
Chen, Mingwei
Asefa, Tewodros
Chhowalla, Manish
TI Covalent functionalization of monolayered transition metal
dichalcogenides by phase engineering
SO NATURE CHEMISTRY
LA English
DT Article
ID SINGLE-LAYER MOS2; CHEMICALLY EXFOLIATED MOS2; WALLED CARBON NANOTUBES;
HYDROGEN EVOLUTION; RESTACKED MOS2; NANOSHEETS; WS2; PHOTOLUMINESCENCE;
INTERCALATION; CHEMISTRY
AB Chemical functionalization of low-dimensional materials such as nanotubes, nanowires and graphene leads to profound changes in their properties and is essential for solubilizing them in common solvents. Covalent attachment of functional groups is generally achieved at defect sites, which facilitate electron transfer. Here, we describe a simple and general method for covalent functionalization of two-dimensional transition metal dichalcogenide nanosheets (MoS2, WS2 and MoSe2), which does not rely on defect engineering. The functionalization reaction is instead facilitated by electron transfer between the electron-rich metallic 1T phase and an organohalide reactant, resulting in functional groups that are covalently attached to the chalcogen atoms of the transition metal dichalcogenide. The attachment of functional groups leads to dramatic changes in the optoelectronic properties of the material. For example, we show that it renders the metallic 1T phase semiconducting, and gives it strong and tunable photoluminescence and gate modulation in field-effect transistors.
C1 [Voiry, Damien; Kappera, Rajesh; Castro e Silva, Cecilia de Carvalho; Chhowalla, Manish] Rutgers State Univ, Piscataway, NJ 08854 USA.
[Goswami, Anandarup; Asefa, Tewodros] Rutgers State Univ, Dept Chem & Chem Biol, Piscataway, NJ 08854 USA.
[Goswami, Anandarup; Asefa, Tewodros] Rutgers State Univ, Dept Chem & Biochem Engn, Piscataway, NJ 08854 USA.
[Kaplan, Daniel] US Army RDECOM ARDEC, Acoust & Networked Sensors Div, Picatinny Arsenal, NJ 07806 USA.
[Fujita, Takeshi; Chen, Mingwei] Tohoku Univ, WPI Adv Inst Mat Res, Sendai, Miyagi 9808577, Japan.
[Fujita, Takeshi] JST, PRESTO, Kawaguchi, Saitama 3320012, Japan.
RP Chhowalla, M (reprint author), Rutgers State Univ, 607 Taylor Rd, Piscataway, NJ 08854 USA.
EM manish1@rci.rutgers.edu
RI Fujita, Takeshi/B-1867-2009; Chen, Mingwei/A-4855-2010; Voiry,
Damien/G-3541-2016;
OI Fujita, Takeshi/0000-0002-2318-0433; Chen, Mingwei/0000-0002-2850-8872;
Voiry, Damien/0000-0002-1664-2839; Kappera, Rajesh/0000-0003-1792-4405
FU National Science Foundation Division of Graduate Education (NSF DGE)
[0903661]; NSF [Chemistry-1004218, DMR-0968937, NanoEHS-1134289];
Conselho Nacional de Desenvolvimento Cientifico e Tecnologico-Brazil;
Japan Science and Technology Agency-PRESTO; Japan Society for Promotion
of Science [90363382]
FX M. Chhowalla, D.V. and R.K. acknowledge financial support from the
National Science Foundation Division of Graduate Education (NSF DGE)
0903661. T.A. and A.G. acknowledge financial assistance from the NSF
(CAREER Chemistry-1004218, DMR-0968937, NanoEHS-1134289, NSF-Analytical
Chemistry Instrumentation Facility and a Special Creativity Grant). C.S.
acknowledges the Conselho Nacional de Desenvolvimento Cientifico e
Tecnologico-Brazil, for a fellowship. T.F. acknowledges partial support
from Japan Science and Technology Agency-PRESTO ('New Materials Science
and Element Strategy') and Japan Society for Promotion of Science
(Grant-in-Aid for Scientific Research on Innovative Areas 'Science of
Atomic Layers', 90363382). The authors thank G.S. Hall for ATR-FTIR
measurements. G. Recine at New York University Polytechnic is thanked
for computing time.
NR 32
TC 91
Z9 91
U1 60
U2 344
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1755-4330
EI 1755-4349
J9 NAT CHEM
JI Nat. Chem.
PD JAN
PY 2015
VL 7
IS 1
BP 45
EP 49
DI 10.1038/NCHEM.2108
PG 5
WC Chemistry, Multidisciplinary
SC Chemistry
GA AW6XQ
UT WOS:000346409400011
PM 25515889
ER
PT J
AU Blake, MB
Saleh, I
Wei, Y
Schlesinger, ID
Yale-Loehr, A
Liu, XZ
AF Blake, M. Brian
Saleh, Iman
Wei, Yi
Schlesinger, Ian D.
Yale-Loehr, Alexander
Liu, Xuanzhe
TI Shared service recommendations from requirement specifications: A hybrid
syntactic and semantic toolkit
SO INFORMATION AND SOFTWARE TECHNOLOGY
LA English
DT Article
DE Requirements engineering; Similarity analysis; Shared service discovery
ID WEB SERVICES
AB Context: Software Requirement Specifications (SRSs) are central to software lifecycles. An SRS defines the functionalities and constraints of a desired software system, hence it often serves as reference for further development. Software lifecycles concerned with the conversion of traditional systems into more service-oriented infrastructures can benefit from understanding potential shared capabilities through the analysis of SRSs.
Objective: In this paper, we propose an automated approach capable of recommending shared software services from multiple text-based SRSs created by different organizations. Our goal is to facilitate the identification of overlapping requirements in these specifications and subsequently recommend shared components, which promotes software reuse. The shared components can be implemented as services that are invoked across different systems.
Method: Our approach leverages the syntactic similarity of the SRS text augmented with semantic information derived from the WordNet database. This work extends our earlier studies by introducing an algorithm that utilizes noun, verb, and predicate relations to enhance the discovery of equivalent requirements and the recommendation of reusable services. A prototype system is implemented to evaluate the approach and experimental results have shown effective recommendation of requirements and their realized shared services.
Results: our automatic recommendation approach generates recommendations in few minutes compared to 9 h when services are manually inspected by developers. Our approach is also able to recommend services that are overlooked by the same developers, and to identify similarity between requirements even if these requirements are reworded.
Conclusion: We show through experimentation that we can efficiently recommend services by leveraging both the syntactical structure and the semantic information of a requirements document and that our approach is more effective than the manual selection of services by experts. We also show that our approach is effective in detecting similar requirements for a single system and hence discovering opportunities for software reuse. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Blake, M. Brian; Saleh, Iman] Univ Miami, Coral Gables, FL 33124 USA.
[Wei, Yi] Microsoft Corp, Seattle, WA USA.
[Schlesinger, Ian D.] Georgetown Univ, Washington, DC USA.
[Yale-Loehr, Alexander] US Army Corps Engn, Alexandria, VA USA.
[Liu, Xuanzhe] Peking Univ, Beijing 100871, Peoples R China.
RP Saleh, I (reprint author), Univ Miami, Coral Gables, FL 33124 USA.
EM iman@miami.edu
FU NSF [0940553, 1004014, 0705130]
FX We would like to acknowledge the prior work and discussions with Mr.
Michael F. Nowlan with regards to the TSM-L approach. We acknowledge
discussions with Dr. Aubrey Rembert in the development of the
recommendation modeling. This work was supported in part by NSF Award
Nos. 0940553, 1004014, and 0705130.
NR 33
TC 0
Z9 0
U1 3
U2 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0950-5849
EI 1873-6025
J9 INFORM SOFTWARE TECH
JI Inf. Softw. Technol.
PD JAN
PY 2015
VL 57
BP 392
EP 404
DI 10.1016/j.infsof.2014.05.019
PG 13
WC Computer Science, Information Systems; Computer Science, Software
Engineering
SC Computer Science
GA AU9YI
UT WOS:000345947500023
ER
PT J
AU Wilson, KL
Allen, MS
Ahrens, RNM
Netherland, MD
AF Wilson, Kyle L.
Allen, Micheal S.
Ahrens, Robert N. M.
Netherland, Michael D.
TI Use of underwater video to assess freshwater fish populations in dense
submersed aquatic vegetation
SO MARINE AND FRESHWATER RESEARCH
LA English
DT Article
DE complex habitats; fish sampling; Hydrilla verticillata; invasive aquatic
plants; largemouth bass; sunfish; video cameras
ID COUNT DATA; BLUEGILL SUNFISH; CAMERA SYSTEM; ABUNDANCE; FLORIDA; LAKES;
COMMUNITIES; MACROPHYTES; PATTERNS; BEHAVIOR
AB Underwater video cameras (UVC) provide a non-lethal technique to sample fish in dense submersed aquatic vegetation. Fish often inhabit densely vegetated areas, but deficiencies of most sampling gears bias relative abundance estimates that inform fisheries management. This study developed methods using UVC to estimate relative abundance in dense vegetation using three experimental ponds covered with surface-matted hydrilla (Hydrilla verticillata) stocked at different densities of Lepomis spp. and largemouth bass (Micropterus salmoides). We conducted UVC point counts over 13 weeks to measure relative fish abundance and occurrence from video analysis. Ponds were then drained to obtain true fish densities. In total, fish were detected in 55% of all counts and juvenile and adult Lepomis spp. and largemouth bass were enumerated. End-of-season true fish densities ranged across ponds (from 52 to 37 000 fish ha(-1)). Additionally, pond 2's true density changed substantially from 370 to 12 300 fish ha(-1). True population size was accurately reflected in differences in estimated relative abundances obtained from fish counts, as in pond 2 where mean fish counts increased from 0.10 in week 1 to 2.33 by week 13. Underwater video accurately and precisely quantified relative abundance at naturally-occurring fish densities, but this success was reduced at low densities.
C1 [Wilson, Kyle L.; Allen, Micheal S.; Ahrens, Robert N. M.] Univ Florida, Sch Forest Resources & Conservat, Fisheries & Aquat Sci Program, Gainesville, FL 32653 USA.
[Netherland, Michael D.] US Army, Engn Res & Dev Ctr, Gainesville, FL 32653 USA.
RP Wilson, KL (reprint author), Univ Calgary, Dept Biol Sci, 2500 Univ Dr NW, Calgary, AB T2N 1N4, Canada.
EM wilsok@ucalgary.ca
OI Wilson, Kyle/0000-0002-0870-0509
FU Florida Fish and Wildlife Conservation Commission Invasive Plant
Management Section
FX The authors thank the Florida Fish and Wildlife Conservation Commission
Invasive Plant Management Section for financial support and the United
States Geological Survey South-eastern Ecological Science Center for
logistics and access to the experimental ponds. They would also like to
thank the University of Florida's Dan Gwinn, Ed Camp, and Jeremy Slade
for advice during the development of this manuscript, as well as Erin
Bradshaw, Nicholas Cole, Zack Slagle, Simone Nageon de Lestang, and
Antonio Malouf for field collections and video analysis. We thank the
Associate Editor, Russell Death, as well as Brendan Ebner and three
anonymous reviewers for the feedback to improve the manuscript.
NR 54
TC 1
Z9 1
U1 5
U2 44
PU CSIRO PUBLISHING
PI COLLINGWOOD
PA 150 OXFORD ST, PO BOX 1139, COLLINGWOOD, VICTORIA 3066, AUSTRALIA
SN 1323-1650
EI 1448-6059
J9 MAR FRESHWATER RES
JI Mar. Freshw. Res.
PY 2015
VL 66
IS 1
BP 10
EP 22
DI 10.1071/MF13230
PG 13
WC Fisheries; Limnology; Marine & Freshwater Biology; Oceanography
SC Fisheries; Marine & Freshwater Biology; Oceanography
GA AW3KH
UT WOS:000346184900002
ER
PT J
AU Guo, ZR
Hong, J
Zheng, J
Chen, WN
AF Guo, Zherui
Hong, Jihye
Zheng, James
Chen, Weinong
TI Out-of-plane effects on dynamic pull-out of p-phenylene terephthalamide
yarns
SO TEXTILE RESEARCH JOURNAL
LA English
DT Article
DE yarn; pull-out; dynamic; out-of-plane; pendulum; impact
ID BALLISTIC IMPACT ENERGY; SINGLE YARN; BEHAVIOR; PERFORMANCE; MECHANISM;
FRICTION
AB In this study, the mechanical response of a single yarn pull-out from single layers of Kevlar (R) and Twaron (R) fabric under out-of-plane loading at dynamic rates was experimentally investigated, as ballistic applications typically occur at higher velocities and out-of-plane directions compared to previous literature. In order to perform the dynamic experiments, a pendulum impact setup was designed and constructed to pull out a single yarn dynamically. The pull-out load was measured directly by a load cell and the movement of the fabric was measured to portray the load-displacement history. The effects of fabric length, out-of-plane versus in-plane yarn pull-out, and constraining boundary conditions were compared.
C1 [Guo, Zherui; Chen, Weinong] Purdue Univ, Sch Aeronaut & Astronaut, W Lafayette, IN 47906 USA.
[Hong, Jihye] Jatco Korea Engn Corp, Seoul, South Korea.
[Zheng, James] US Army, Program Execut Off Soldier, Brooklyn, NY USA.
[Chen, Weinong] Purdue Univ, Sch Mat Engn, W Lafayette, IN 47907 USA.
RP Guo, ZR (reprint author), Purdue Univ, Sch Aeronaut & Astronaut, 2116 McCormick Rd, W Lafayette, IN 47906 USA.
EM gzherui@purdue.edu
NR 15
TC 0
Z9 0
U1 0
U2 4
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0040-5175
EI 1746-7748
J9 TEXT RES J
JI Text. Res. J.
PD JAN
PY 2015
VL 85
IS 2
BP 140
EP 149
DI 10.1177/0040517514542865
PG 10
WC Materials Science, Textiles
SC Materials Science
GA AU6XK
UT WOS:000345744600003
ER
PT J
AU Whipps, GT
Ertin, E
Moses, RL
AF Whipps, Gene T.
Ertin, Emre
Moses, Randolph L.
GP IEEE
TI Distributed Sensing for Quickest Change Detection of Point Radiation
Sources
SO 2015 18TH INTERNATIONAL CONFERENCE ON INFORMATION FUSION (FUSION)
LA English
DT Proceedings Paper
CT 18th International Conference on Information Fusion (Fusion)
CY JUL 06-09, 2015
CL Washington, DC
AB We consider the problem of distributed detection of a radioactive source using a network of emission count sensors. Sensor nodes observe their environment and a central fusion node attempts to detect a change in the joint probability distribution due to the appearance of a hazardous source at an unknown time and location. We consider a minimax-type distributed change-point detection problem that minimizes detection delay for a desired false alarm rate. A statistical model of the radiation source detection problem is formulated where sensors observations are correlated with non-identical distributions. We first derive a centralized detection algorithm that is asymptotically optimal for vanishing false alarm rate. Then we analyze the performance loss, as measured by the detection latency, when sensor counts are quantized at each sensor node. The detection latency of the centralized rule provides a lower bound on performance for the proposed distributed method. The empirical results indicate that the distributed detection strategy provides a reasonable tradeoff between latency and information bandwidth.
C1 [Whipps, Gene T.; Ertin, Emre; Moses, Randolph L.] Ohio State Univ, ECE Dept, Columbus, OH 43210 USA.
[Whipps, Gene T.] US Army Res Lab, Adelphi, MD 20783 USA.
RP Whipps, GT (reprint author), Ohio State Univ, ECE Dept, Columbus, OH 43210 USA.
NR 11
TC 0
Z9 0
U1 1
U2 1
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-0-9824-4386-6
PY 2015
BP 22
EP 27
PG 6
WC Computer Science, Artificial Intelligence; Computer Science,
Interdisciplinary Applications; Engineering, Electrical & Electronic
SC Computer Science; Engineering
GA BG5KW
UT WOS:000389523300004
ER
PT J
AU Verma, D
Leland, W
Pham, T
Swami, A
Cirincione, G
AF Verma, Dinesh
Leland, Will
Tien Pham
Swami, Ananthram
Cirincione, Greg
GP IEEE
TI Advances in Network Sciences via Collaborative Multi-Disciplinary
Research
SO 2015 18TH INTERNATIONAL CONFERENCE ON INFORMATION FUSION (FUSION)
LA English
DT Proceedings Paper
CT 18th International Conference on Information Fusion (Fusion)
CY JUL 06-09, 2015
CL Washington, DC
DE Network Science; Research Alliances
AB Network Science is the scientific exploration of the shared fundamental properties underlying different types of networks and their interactions. Two large research alliances, the International Technology Alliance in Network Sciences and the Network Science Collaborative Technology Alliance, have brought together researchers from many diverse disciplines to create fundamental advances in network science. In this paper, we discuss some of the advances made by the scientists in these two research alliances, and some of the lessons learnt as fundamental scientific advances are translated to real networks via military and commercial transitions. Since both of the alliances themselves are complex networks, some of the lessons learnt from management of these networks are also discussed briefly in this paper.
C1 [Verma, Dinesh] IBM TJ Watson Res, 1101 Kitchawan Rd, Yorktown Hts, NY 10598 USA.
[Leland, Will] Raytheon BBN Technol, 10 Moulton St, Cambridge, MA 02138 USA.
[Tien Pham; Swami, Ananthram; Cirincione, Greg] US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
RP Verma, D (reprint author), IBM TJ Watson Res, 1101 Kitchawan Rd, Yorktown Hts, NY 10598 USA.
EM dverma@us.ibm.com; wel@bbn.com; tien.pham1.civ@mail.mil;
ananthram.swami.civ@mail.mil; gregory.h.cirincione.civ@mail.mil
NR 59
TC 0
Z9 0
U1 1
U2 1
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-0-9824-4386-6
PY 2015
BP 186
EP 193
PG 8
WC Computer Science, Artificial Intelligence; Computer Science,
Interdisciplinary Applications; Engineering, Electrical & Electronic
SC Computer Science; Engineering
GA BG5KW
UT WOS:000389523300026
ER
PT J
AU Pham, T
Cirincione, G
Swami, A
Pearson, G
Williams, C
AF Pham, Tien
Cirincione, Gregory
Swami, Ananthram
Pearson, Gavin
Williams, Christopher
GP IEEE
TI Distributed Analytics and Information Science
SO 2015 18TH INTERNATIONAL CONFERENCE ON INFORMATION FUSION (FUSION)
LA English
DT Proceedings Paper
CT 18th International Conference on Information Fusion (Fusion)
CY JUL 06-09, 2015
CL Washington, DC
DE analytics; fusion; distributed; networks; security; information
processing; military; coalition
ID SOFTWARE-DEFINED NETWORKING
AB To address future coalition operations in congested, cluttered, contested, connected and constrained battlespace, the US Army Research Laboratory and the UK Defence Science and Technology Laboratory are developing a new research program on Distributed Analytics and Information Science International Technology Alliance. In this paper, we present an overview the two interrelated Technical Areas which when jointly studied will advance the theoretical foundations of distributed analytics and information science in the context of coalition operations. These areas are (1) Dynamic, Secure Coalition Information Infrastructures and (2) Coalition Distributed Analytics and Situational Understanding.
C1 [Pham, Tien; Cirincione, Gregory; Swami, Ananthram] US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
[Pearson, Gavin; Williams, Christopher] Def Sci & Technol Lab, Salisbury SP4 0JQ, Wilts, England.
RP Pham, T (reprint author), US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM tien.pham1.civ@mail.mil; gregory.h.cirincione.civ@mail.mil;
ananthram.swami.civ@mail.mil; agpearson@mail.dstl.gov.uk;
cwilliams@mail.dstl.gov.uk
NR 18
TC 0
Z9 0
U1 1
U2 4
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-0-9824-4386-6
PY 2015
BP 245
EP 252
PG 8
WC Computer Science, Artificial Intelligence; Computer Science,
Interdisciplinary Applications; Engineering, Electrical & Electronic
SC Computer Science; Engineering
GA BG5KW
UT WOS:000389523300034
ER
PT J
AU Kaplan, L
Ivanovska, M
Josang, A
Sambo, F
AF Kaplan, Lance
Ivanovska, Magdalena
Josang, Audun
Sambo, Francesco
GP IEEE
TI Towards Subjective Networks: Extending Conditional Reasoning in
Subjective Logic
SO 2015 18TH INTERNATIONAL CONFERENCE ON INFORMATION FUSION (FUSION)
LA English
DT Proceedings Paper
CT 18th International Conference on Information Fusion (Fusion)
CY JUL 06-09, 2015
CL Washington, DC
ID PROBABILITIES
AB This work expands the concept of conditional reasoning in subjective logic between two variables to reasoning over multiple variables as a step to eventually realize efficient means for inference over subjective networks, i.e. Bayesian networks with uncertain marginal and conditional probabilities. Three new inference methods are introduced for a three node subjective network. Monte Carlo simulations characterize the accuracy of these methods to represent inferred uncertain knowledge about the ground truth.
C1 [Kaplan, Lance] US Army, Res Lab, Adelphi, MD 20783 USA.
[Ivanovska, Magdalena; Josang, Audun] Univ Oslo, Oslo, Norway.
[Sambo, Francesco] Univ Padua, Padua, Italy.
RP Kaplan, L (reprint author), US Army, Res Lab, Adelphi, MD 20783 USA.
NR 16
TC 1
Z9 1
U1 1
U2 1
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-0-9824-4386-6
PY 2015
BP 319
EP 326
PG 8
WC Computer Science, Artificial Intelligence; Computer Science,
Interdisciplinary Applications; Engineering, Electrical & Electronic
SC Computer Science; Engineering
GA BG5KW
UT WOS:000389523300043
ER
PT J
AU Oltramari, A
Cho, JH
AF Oltramari, Alessandro
Cho, Jin-Hee
GP IEEE
TI ComTrustO: Composite Trust-based Ontology Framework for Information and
Decision Fusion
SO 2015 18TH INTERNATIONAL CONFERENCE ON INFORMATION FUSION (FUSION)
LA English
DT Proceedings Paper
CT 18th International Conference on Information Fusion (Fusion)
CY JUL 06-09, 2015
CL Washington, DC
DE ontology; composite trust; information fusion; quality-of-service;
quality-of-information; social trust; cognition; situation awareness
ID ENVIRONMENTS
AB Interactions between humans and machines are often placed in a multi-layered network involving the multidimensional trust in communication, information, and socio-cognitive layers. In this complex environment, how to filter and fuse heterogeneous data is critical for effective decision making. In this work, we propose an ontology-based framework for information fusion, as a support system for human decision makers. In particular, we build upon the concept of composite trust, consisting of four trust types: communication trust, information trust, social trust, and cognitive trust. Based on the concept of multidimensional trust, we construct a composite trust ontology framework, called ComTrustO, that embraces four trust ontologies, one for each trust type. We present the details of the integrated ontology framework and discuss a concrete example scenario.
C1 [Oltramari, Alessandro] Carnegie Mellon Univ, Pittsburgh, PA 15213 USA.
[Cho, Jin-Hee] US Army, Res Lab, Adelphi, MD USA.
RP Oltramari, A (reprint author), Carnegie Mellon Univ, Pittsburgh, PA 15213 USA.
EM aoltrama@andrew.cmu.edu; jinhee.cho@us.army.mil
NR 38
TC 1
Z9 1
U1 2
U2 2
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-0-9824-4386-6
PY 2015
BP 542
EP 549
PG 8
WC Computer Science, Artificial Intelligence; Computer Science,
Interdisciplinary Applications; Engineering, Electrical & Electronic
SC Computer Science; Engineering
GA BG5KW
UT WOS:000389523300073
ER
PT J
AU Sensoy, M
Kaplan, L
Ayci, G
de Mel, G
AF Sensoy, Murat
Kaplan, Lance
Ayci, Gonul
de Mel, Geeth
GP IEEE
TI FUSE-BEE: Fusion of Subjective Opinions through Behavior Estimation
SO 2015 18TH INTERNATIONAL CONFERENCE ON INFORMATION FUSION (FUSION)
LA English
DT Proceedings Paper
CT 18th International Conference on Information Fusion (Fusion)
CY JUL 06-09, 2015
CL Washington, DC
DE Information Fusion; Subjective Logic; Dirichlet Distributions; Behavior
Estimation
ID REPUTATION; TRUST
AB Information is critical in almost all decision making processes. Therefore, it is important to get the right information at the right time from the right sources. However, information sources may behave differently while providing information i.e., they may provide unreliable, erroneous, noisy, or misleading information deliberately or unintentionally. Motivated by this observation, in this paper, we propose a statistical information fusion approach based on behavior estimation. Our approach transforms the conveyed information into more useful form by tempering them with the estimated behaviors of sources. Through extensive simulations, we have shown that our approach has a lower computational complexity, and achieves significantly low behavior estimation and fusion errors.
C1 [Sensoy, Murat; Ayci, Gonul] Ozyegin Univ, Dept Comp Sci, Istanbul, Turkey.
[Kaplan, Lance] US Army, Res Lab, Adelphi, MD 20783 USA.
[de Mel, Geeth] IBM TJ Watson Res Ctr, Hawthorne, NY USA.
RP Sensoy, M (reprint author), Ozyegin Univ, Dept Comp Sci, Istanbul, Turkey.
NR 15
TC 1
Z9 1
U1 1
U2 1
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-0-9824-4386-6
PY 2015
BP 558
EP 565
PG 8
WC Computer Science, Artificial Intelligence; Computer Science,
Interdisciplinary Applications; Engineering, Electrical & Electronic
SC Computer Science; Engineering
GA BG5KW
UT WOS:000389523300075
ER
PT J
AU Chan, K
Marcus, K
Scott, L
Hardy, R
AF Chan, Kevin
Marcus, Kelvin
Scott, Lisa
Hardy, Rommie
GP IEEE
TI Quality of Information Approach to Improving Source Selection in
Tactical Networks
SO 2015 18TH INTERNATIONAL CONFERENCE ON INFORMATION FUSION (FUSION)
LA English
DT Proceedings Paper
CT 18th International Conference on Information Fusion (Fusion)
CY JUL 06-09, 2015
CL Washington, DC
AB Intelligence operations in highly dynamic and constrained networked environments require a prudent strategies to query information sources. We consider the performance of this process based on metrics relating to quality of information: accuracy, timeliness, completeness and reliability. These metrics are identified in military doctrine as requirements that promote mission success. Further, it is possible to identify specific network metrics that are indicators of that the network is meeting these quality requirements. We study effective data rate, social distance, link integrity and the utility of information as metrics within a multi-genre network to determine the quality of information of its available sources. This paper proposes a formulation of the analytic hierarchy process to score information sources based on these concepts. A modification to this algorithm is also presented which incorporates the dynamics of the measurements. This is a multimodal fusion approach that considers elements from communications, information and social networks to assist a decision maker in the source selection problem. We show how this approach can be used to score information sources for such tasks using results from representative simulations.
C1 [Chan, Kevin; Marcus, Kelvin; Scott, Lisa; Hardy, Rommie] US Army, Res Lab, Adelphi, MD 20783 USA.
RP Chan, K (reprint author), US Army, Res Lab, Adelphi, MD 20783 USA.
NR 18
TC 1
Z9 1
U1 1
U2 1
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-0-9824-4386-6
PY 2015
BP 566
EP 573
PG 8
WC Computer Science, Artificial Intelligence; Computer Science,
Interdisciplinary Applications; Engineering, Electrical & Electronic
SC Computer Science; Engineering
GA BG5KW
UT WOS:000389523300076
ER
PT J
AU Deligeorges, S
Lavey, C
Cakiades, G
George, J
Wang, Y
Ez, FN
Doyle, F
AF Deligeorges, S.
Lavey, C.
Cakiades, G.
George, J.
Wang, Y.
Ez, F. N.
Doyle, F.
GP IEEE
TI A Mobile Acoustic Sensor Fusion Network Using Biologically Inspired
Sensors and Synchronization
SO 2015 18TH INTERNATIONAL CONFERENCE ON INFORMATION FUSION (FUSION)
LA English
DT Proceedings Paper
CT 18th International Conference on Information Fusion (Fusion)
CY JUL 06-09, 2015
CL Washington, DC
DE Hostile fire detection; sensor fusion; biologically inspired sensors;
sensor networks; network synchronization
AB Hostile fire detection is a critical component of situational awareness in the asymmetric battlefields of ongoing and future conflicts. The ability to detect and localize sources of hostile fire in difficult environments can dramatically increase the survivability of dismounted warfighters. Existing individual acoustic hostile fire sensors provide useful information but are prone to heading errors, variable bearing and range accuracy, as well as reliability issues due to false alarms, limiting the actionability of the information.
The warfighter can have significantly improved hostile fire sensor performance through affirmation fusion. By leveraging existing sensors as a sensor network, the improvements come without additional weight, equipment, or power draw on the already overburdened soldier. Key to this objective is the ability to synchronize sensors over the network accurately, without using large amounts of power or network bandwidth, even when GPS-denied. Bio-inspired synchronization enables the proposed network infrastructure and makes possible sensor fusion algorithms on mobile platforms.
C1 [Deligeorges, S.; Lavey, C.] BioMimet Syst, Cambridge, MA 02139 USA.
[Cakiades, G.] Picatinny Arsenal, ARDEC, Wharton, NJ USA.
[George, J.] Army Res Lab, Adelphi, MD USA.
[Wang, Y.] Clemson Univ, Clemson, SC USA.
[Ez, F. N.; Doyle, F.] Univ Calif Santa Barbara, Santa Barbara, CA 93106 USA.
RP Deligeorges, S (reprint author), BioMimet Syst, Cambridge, MA 02139 USA.
EM Socrates@BMSacoustics.com; CathyLavey@BMSacoustics.com;
Cakiades.civ@mail.mil; Jemin.George@mail.mil; Yongqiw@clemson.edu;
Fenunez@icb.ucsb.edu; Frank.Doyle@icb.ucsb.edu
NR 12
TC 0
Z9 0
U1 1
U2 1
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-0-9824-4386-6
PY 2015
BP 1717
EP 1723
PG 7
WC Computer Science, Artificial Intelligence; Computer Science,
Interdisciplinary Applications; Engineering, Electrical & Electronic
SC Computer Science; Engineering
GA BG5KW
UT WOS:000389523300226
ER
PT J
AU Chowdhury, RA
Hosur, MV
Nuruddin, M
Tcherbi-Narteh, A
Kumar, A
Boddu, V
Jeelani, S
AF Chowdhury, Reaz A.
Hosur, Mahesh V.
Nuruddin, Md.
Tcherbi-Narteh, Alfred
Kumar, Ashok
Boddu, Veera
Jeelani, Shaik
TI Self-healing epoxy composites: preparation, characterization and healing
performance
SO JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
LA English
DT Article
DE Microcapsules; Synthesis; Low velocity impact; Thermography; Healing
efficiency
AB Low velocity impact damage is common in fiber reinforced composites, which leads to micro-crack and interfacial debonding, where damage is microscopic and invisible. The concept of self-healing composites can be a way of overcoming this limitation and extending the life expectancy while expanding their usage in structural applications. In the current study, extrinsic self-healing concept was adopted using urea-formaldehyde microcapsules containing room temperature curing epoxy resin system (SC-15) as the healing agent prepared by in situ polymerization. Microcapsules were characterized using Fourier transform infrared spectroscopy (FTIR) for structural analysis. Size and shape of microcapsules were studied using optical microscopy and scanning electron microscopy (SEM). Size of the micro capsules was between 30 and 100 mu m. Thermal characterization was carried out using thermogravimetric analysis. Microcapsules were thermally stable till 210 degrees C without any significant decomposition. Fiber reinforced composite fabrication was carried out in three different steps. In the first step, epoxy resin was encapsulated in urea-formaldehyde shell material, which was confirmed by FTIR analysis. In the next step, encapsulation of amine hardener was achieved by vacuum infiltration method. These two different microcapsules were added with epoxy at 10:3 ratio and composite fabrication was done with hand layup method. Finally, healing performance was measured in terms of low velocity impact test and thermoscopy analysis. Low velocity impact test with 30J and 45J impact loads confirmed the delamination and micro-crack in composite materials and subsequent healing recovery observed in terms of damaged area reduction and restoration of mechanical properties. (C) 2014 Brazilian Metallurgical, Materials and Mining Association. Published by Elsevier Editora Ltda. All rights reserved.
C1 [Chowdhury, Reaz A.; Hosur, Mahesh V.; Nuruddin, Md.; Tcherbi-Narteh, Alfred; Jeelani, Shaik] Tuskegee Univ, Dept Mat Sci & Engn, Tuskegee, AL 36088 USA.
[Kumar, Ashok; Boddu, Veera] US Army Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL USA.
RP Hosur, MV (reprint author), Tuskegee Univ, Dept Mat Sci & Engn, Tuskegee, AL 36088 USA.
EM hosur@mytu.tuskegee.edu
FU U.S. Army ERDC-CERL
FX Authors would like to acknowledge the support of U.S. Army ERDC-CERL for
the support to carry out this work.
NR 15
TC 6
Z9 7
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 2238-7854
EI 2214-0697
J9 J MATER RES TECHNOL
JI J. Mater. Res. Technol-JMRT
PD JAN-MAR
PY 2015
VL 4
IS 1
BP 33
EP 43
DI 10.1016/j.jmrt.2014.10.016
PG 11
WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical
Engineering
SC Materials Science; Metallurgy & Metallurgical Engineering
GA V46PS
UT WOS:000209896700007
ER
PT J
AU Davis, C
Conrath, E
Tomanek, M
McKay, A
AF Davis, Carrie
Conrath, Ed
Tomanek, Matt
McKay, Aldo
BE Ingraffea, N
Libby, M
TI Are Window Mullion Response Limits Too Conservative?
SO Structures Congress 2015
LA English
DT Proceedings Paper
CT Structures Congress
CY APR 23-25, 2015
CL Portland, OR
SP Amer Soc Civil Engineers, Struct Engn Inst
AB Design of blast resistant windows is relatively new compared to other facade components such as steel, concrete, and reinforced masonry, but is slowly coming into its own in terms of design procedures and response criteria. Initial response criteria from the mid 1980s - when design procedures for blast resistant windows were initially formulated - limited window framing to L/264 but no more than 1/8-in. There were also stringent wall response criteria when windows attached directly to walls. These criteria were used because monolithic glazing, limited to low probabilities of fracture, was used. In the 1990s and early 2000s, when laminated glass started to become the glazing for blast resistant windows, software using SDOF approaches allowed for the fracture and even flyout of the glazing - depending on the level of protection to be used. However, frame response was still rather stringent and vacillated between L/60 and L/160 of the frame member. With the publication of the ASCE document on "Blast Protection of Buildings" and the PDC TR 10-02, "Blast Resistant Design Methodology for Window Systems Designed Statically and Dynamically", frame response criteria for windows, storefront systems, and curtain walls became less stringent and varied depending on the level of protection to be used. Recent testing has shown that even the latest response criteria may be somewhat conservative for different levels of protection. The test information is somewhat limited since most window systems are tested to show compliance with different glazing hazard levels/performance conditions, but limited available data where deflection of mullions was tracked during dynamic loading, showed low glazing hazards even though frame response was greater than would be allowed for design. This paper presents a historical perspective of how response limits and glazing design have progressed over the years and then presents available data showing that low glazing hazards against blast loads can be achieved even though the frame response is much greater than the current allowable limits.
C1 [Davis, Carrie; McKay, Aldo] Protect Engn Consultants, 14144 Trautwein Rd, Austin, TX 78737 USA.
[Conrath, Ed] Protect Engn Consultants, Omaha, NE USA.
[Tomanek, Matt] US Army Corps Engineers, Protect Design Ctr, Omaha, NE USA.
RP Davis, C (reprint author), Protect Engn Consultants, 14144 Trautwein Rd, Austin, TX 78737 USA.
EM cdavis@protection-consultants.com; econrath@protection-consultants.com;
Matthew.T.Tomanek@usace.army.mil; amkcay@protection-consultants.com
NR 11
TC 0
Z9 0
U1 0
U2 1
PU AMER SOC CIVIL ENGINEERS
PI NEW YORK
PA UNITED ENGINEERING CENTER, 345 E 47TH ST, NEW YORK, NY 10017-2398 USA
BN 978-0-7844-7911-7
PY 2015
BP 1
EP 12
PG 12
WC Construction & Building Technology; Engineering, Civil; Engineering,
Mechanical
SC Construction & Building Technology; Engineering
GA BG8WG
UT WOS:000392737000001
ER
PT J
AU Rowell, SP
AF Rowell, Stephen P.
BE Ingraffea, N
Libby, M
TI Performance of Reinforcement Bar Mechanical Couplers at Low, Medium, and
High Strain-Rates
SO Structures Congress 2015
LA English
DT Proceedings Paper
CT Structures Congress
CY APR 23-25, 2015
CL Portland, OR
SP Amer Soc Civil Engineers, Struct Engn Inst
AB The Unified Facilities Criteria (UFC) 3-340-02, formerly Army Technical Manual 5-1300/NAVFAC P-397/AFR 88-22 (TM 5-1300), defines the criteria for designing reinforced concrete structures to resist blast effects from accidental explosions. The recent Change 1 to the UFC 3-340-02 included an update to section 4-21.8 "Mechanical Splices of Reinforcement." This update added the validation test requirements and the acceptance criteria for the use of mechanical couplers in place of lap splicing of steel reinforcing bars in elements at specific locations and under certain conditions. Several types of mechanical couplers have been tested and validated for developing the strength of reinforcing steel for cyclic loading and strain-rates expected during earthquakes. However, no mechanical couplers were shown to meet the longstanding section 4-21.8 requirement that the coupler be capable of developing the ultimate dynamic tensile strength of the reinforcing bar under high strain-rate loading without reducing its ductility. This paper presents the results of tests performed by the U.S. Army Engineer Research and Development Center (ERDC) and documented in ERDC Technical Report TR-09-8, "High Strain-Rate Testing of Mechanical Couplers." Five different types of mechanical couplers that meet the American Concrete Institute 318 type II requirements were dynamically tested at low, medium, and high strain-rates to obtain their measured performances. The performances of these mechanical couplers were compared to control bars tested at the same strain-rates. The test results were evaluated to determine if requirements of TM 5-1300 and UFC 3-340-02 were achieved. While the evaluation showed that these five mechanical couplers did not consistently meet the section 4-21.8 requirement for unrestricted use, the tests did demonstrate adequate performance for certain couplers at lower response limits. The recent Change 1 of the UFC 3-340-02 is discussed and compared to the previous requirements to provide the industry guidance and a path forward to further testing and validation of mechanical couplers for use in hardened structures.
C1 [Rowell, Stephen P.] US Army Engineer Res & Dev Ctr ERDC, Struct Mech Branch, Geosci & Struct Div, Geotech & Struct Lab,ATTN CEERD GSM, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
RP Rowell, SP (reprint author), US Army Engineer Res & Dev Ctr ERDC, Struct Mech Branch, Geosci & Struct Div, Geotech & Struct Lab,ATTN CEERD GSM, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM stephen.p.rowell@usace.army.mil
FU NAVFAC EXWC
FX The research reported herein was conducted under the High Strain-Rate
Mechanical Coupler Tests project sponsored by NAVFAC EXWC. Mr. Kevin
Hager of NAVFAC EXWC served as the Program Manager. Permission from the
Director, Geotechnical and Structures Laboratory, and the NAVFAC EXWC to
publish this paper is gratefully acknowledged. Approved for public
release; distribution is unlimited.
NR 6
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC CIVIL ENGINEERS
PI NEW YORK
PA UNITED ENGINEERING CENTER, 345 E 47TH ST, NEW YORK, NY 10017-2398 USA
BN 978-0-7844-7911-7
PY 2015
BP 99
EP 114
PG 16
WC Construction & Building Technology; Engineering, Civil; Engineering,
Mechanical
SC Construction & Building Technology; Engineering
GA BG8WG
UT WOS:000392737000009
ER
PT J
AU North, T
AF North, Thomas
BE Ingraffea, N
Libby, M
TI Bridge Load Rating Practices for Cranes
SO Structures Congress 2015
LA English
DT Proceedings Paper
CT Structures Congress
CY APR 23-25, 2015
CL Portland, OR
SP Amer Soc Civil Engineers, Struct Engn Inst
AB Oversized and overweight Rough Terrain (RT) and All Terrain (AT) commercial cranes are used extensively at dam projects and continuously cross bridges that serve the requirements of the public agencies or private utilities that own them. Depending on the state jurisdiction, these cranes will be trailered or driven under a variety of local and multistate permit programs. The effects of crane loads on highway bridges are a frequent concern due to the variability in age, design, construction, and condition of the bridges. Currently, the only guidance available for analysis is criteria outlined in AASHTO Load and Resistance Factor Design (LRFD) Bridge Design Specifications and AASHTO Guide Manual for the Condition Evaluation and Load and Resistance Factor Rating of Highway Bridges (LRFR). The information in this presentation will help determine safe loading capacity and placement of three common types of classifications of oversized cranes on a bridge. It is based on vehicular loading and requires an analysis methodology that extrapolates an allowable crane permit loading from the LRFR bridge design or legal loading. The differences between vehicular & crane live and static loads, axle configurations, and load placements are discussed. There are recommendations for making informed decisions on adjustments in impact loads, live load distributions and lane loading based on the Strength II requirements outlined in the evaluation and rating procedures in the AASHTO LRFR and LRFD specifications. This article will also show an outline for planning a crane operation on a bridge that includes consideration of working loads, placement and minimizing risks.
C1 [North, Thomas] US Army, Corps Engineers, Northernwestern Div, 1125 NW Couch St,Suite 500, Portland, OR 97209 USA.
RP North, T (reprint author), US Army, Corps Engineers, Northernwestern Div, 1125 NW Couch St,Suite 500, Portland, OR 97209 USA.
EM thomas.north@usace.army.mil
NR 4
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC CIVIL ENGINEERS
PI NEW YORK
PA UNITED ENGINEERING CENTER, 345 E 47TH ST, NEW YORK, NY 10017-2398 USA
BN 978-0-7844-7911-7
PY 2015
BP 172
EP 182
PG 11
WC Construction & Building Technology; Engineering, Civil; Engineering,
Mechanical
SC Construction & Building Technology; Engineering
GA BG8WG
UT WOS:000392737000015
ER
PT B
AU Castro, CA
Wilcox, SL
AF Castro, Carl Andrew
Wilcox, Sherrie Leigh
BE Powles, A
Partow, N
Nelson, N
TI Mental Health and Combat Veterans
SO UNITED NATIONS PEACEKEEPING CHALLENGE: THE IMPORTANCE OF THE INTEGRATED
APPROACH
SE Global Security in a Changing World
LA English
DT Proceedings Paper
CT 8th Pacific Army Chiefs Conference / 37th Seminar on Pacific Armies
Management
CY SEP, 2013
CL Auckland, NEW ZEALAND
SP New Zealand Army, US Army
C1 [Castro, Carl Andrew] Univ Southern Calif, Sch Social Work, Los Angeles, CA 90089 USA.
[Castro, Carl Andrew] US Army Med Res Unit Europe, Heidelberg, Germany.
[Castro, Carl Andrew] US Army Med Res & Mat Command, Res Program, Walter Reed Army Inst, Dept Mil Psychiat, Ft Detrick, MD USA.
[Wilcox, Sherrie Leigh] USC, Sch Social Work, Los Angeles, CA USA.
[Wilcox, Sherrie Leigh] USC, Ctr Innovat & Res Vet & Mil Families, Los Angeles, CA USA.
RP Castro, CA (reprint author), Univ Southern Calif, Sch Social Work, Los Angeles, CA 90089 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ASHGATE PUBLISHING LTD
PI ALDERSHOT
PA GOWER HOUSE, CROFT ROAD, ALDERSHOT GU11 3HR, ENGLAND
BN 978-1-47-243247-6; 978-1-47-243246-9
J9 GLOB SECUR CHANG WOR
PY 2015
BP 149
EP 166
PG 18
WC International Relations
SC International Relations
GA BG6UT
UT WOS:000390845200013
ER
PT B
AU Flavin, W
AF Flavin, William
BE Powles, A
Partow, N
Nelson, N
TI Teaming for Success
SO UNITED NATIONS PEACEKEEPING CHALLENGE: THE IMPORTANCE OF THE INTEGRATED
APPROACH
SE Global Security in a Changing World
LA English
DT Proceedings Paper
CT 8th Pacific Army Chiefs Conference / 37th Seminar on Pacific Armies
Management
CY SEP, 2013
CL Auckland, NEW ZEALAND
SP New Zealand Army, US Army
C1 [Flavin, William] US Army War Coll, US Army Peacekeeping & Stabil Operat Inst PKSOI, Carlisle, PA 17013 USA.
[Flavin, William] PKSOI, Doctrine & Educ Div, Carlisle, PA USA.
[Flavin, William] Booz Allen & Hamilton Inc, Mclean, VA USA.
[Flavin, William] Ctr Strateg & Int Studies, Washington, DC 20006 USA.
[Flavin, William] Army War Coll, Carlisle, PA USA.
RP Flavin, W (reprint author), US Army War Coll, US Army Peacekeeping & Stabil Operat Inst PKSOI, Carlisle, PA 17013 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ASHGATE PUBLISHING LTD
PI ALDERSHOT
PA GOWER HOUSE, CROFT ROAD, ALDERSHOT GU11 3HR, ENGLAND
BN 978-1-47-243247-6; 978-1-47-243246-9
J9 GLOB SECUR CHANG WOR
PY 2015
BP 217
EP 233
PG 17
WC International Relations
SC International Relations
GA BG6UT
UT WOS:000390845200017
ER
PT J
AU Cotter, JL
Rael, JS
AF Cotter, J. L.
Rael, J. S.
BE Karvazy, K
Webster, VL
TI History of Federal Dam Construction in Texas
SO World Environmental and Water Resources Congress 2015: Floods, Droughts,
and Ecosystems
LA English
DT Proceedings Paper
CT World Environmental and Water Resources Congress
CY MAY 17-21, 2015
CL Austin, TX
SP Amer Soc Civil Engineers, Environm and Water Resources Inst
C1 [Cotter, J. L.; Rael, J. S.] US Army Corps Engn, Water Resource Branch, 819 Taylor St, Ft Worth, TX 76102 USA.
RP Cotter, JL (reprint author), US Army Corps Engn, Water Resource Branch, 819 Taylor St, Ft Worth, TX 76102 USA.
EM Jerry.L.Cotter@usace.army.mil; John.S.Rael@usace.army.mil
NR 14
TC 0
Z9 0
U1 0
U2 1
PU AMER SOC CIVIL ENGINEERS
PI NEW YORK
PA UNITED ENGINEERING CENTER, 345 E 47TH ST, NEW YORK, NY 10017-2398 USA
BN 978-0-7844-7916-2
PY 2015
BP 74
EP 94
PG 21
WC Engineering, Civil; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA BG8ZE
UT WOS:000392856300008
ER
PT J
AU Davis, DW
Fredrich, AJ
AF Davis, Darryl W.
Fredrich, Augustine J.
BE Karvazy, K
Webster, VL
TI The Hydrologic Engineering Center-50 Years of Hydrologic Engineering
History
SO World Environmental and Water Resources Congress 2015: Floods, Droughts,
and Ecosystems
LA English
DT Proceedings Paper
CT World Environmental and Water Resources Congress
CY MAY 17-21, 2015
CL Austin, TX
SP Amer Soc Civil Engineers, Environm and Water Resources Inst
AB The Hydrologic Engineering Center (HEC) was founded in 1964 by the U.S. Army Corps of Engineers (USACE 1989). Digital computers were just becoming widely available and the founders quickly recognized the potential for automating laborious manual calculations and extending applications to problems not here-to-fore practical. Their shared vision of achieving economy and consistency in hydrologic analysis and in exploiting the use of digital computers resulted in the creation of the discipline known today as hydrologic engineering and the Hydrologic Engineering Center as the organizational vehicle for making their vision a reality. HEC was created as a three-pronged organization designed to achieve the goal of improving USACE capability for hydrologic engineering. The three elements of the HEC mission were methods systemization and training, research, and special assistance. The three elements of the mission were integrated to provide feedback from users in Corps field offices to HEC so that the work at HEC remained focused on the needs of engineers engaged in real-world problem solving. The size of HEC has remained remarkably constant over the years - about 35 permanent staff plus a complement of students. In its 50-year history the Hydrologic Engineering Center has been a model for the development of technical expertise and knowledge sharing. Its work has been acclaimed by many and emulated by others in both the public and private sectors, and it stands as a singular example of how the vision of its founders could endure through half a century of technological changes that surpassed even their greatest expectations of what the profession of hydrologic engineering could become.
C1 [Davis, Darryl W.] US Army Corps Engineers, Inst Water Resources, 801 Malaga Ave, Davis, CA 95616 USA.
[Fredrich, Augustine J.] Univ Southern Indiana, Engn, Little Rock, AR 72212 USA.
RP Davis, DW (reprint author), US Army Corps Engineers, Inst Water Resources, 801 Malaga Ave, Davis, CA 95616 USA.
EM Darryl.W.Davis@usace.army.mil; ajfredrich@gmail.com
NR 10
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC CIVIL ENGINEERS
PI NEW YORK
PA UNITED ENGINEERING CENTER, 345 E 47TH ST, NEW YORK, NY 10017-2398 USA
BN 978-0-7844-7916-2
PY 2015
BP 161
EP 170
PG 10
WC Engineering, Civil; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA BG8ZE
UT WOS:000392856300015
ER
PT J
AU Weston, DM
Skahill, BE
Downer, CW
Graulau-Santiago, JA
Pradhan, N
Byrd, AR
AF Weston, David M.
Skahill, Brian E.
Downer, Charles W.
Graulau-Santiago, Jaime A.
Pradhan, Nawa
Byrd, Aaron R.
BE Karvazy, K
Webster, VL
TI Gridded Surface Subsurface Hydrologic Analysis Modeling for Analysis of
Flood Design Features at the Picayune Strand Restoration Project
SO World Environmental and Water Resources Congress 2015: Floods, Droughts,
and Ecosystems
LA English
DT Proceedings Paper
CT World Environmental and Water Resources Congress
CY MAY 17-21, 2015
CL Austin, TX
SP Amer Soc Civil Engineers, Environm and Water Resources Inst
ID PREDICTION INTERVALS; CONFIDENCE
AB The Picayune Strand Restoration Project is one of many components of the Comprehensive Everglades Restoration Project (CERP) intended to restore nearly 55,000 acres (22,258 hectare) of a failed residential development in southwestern Collier County, Florida, to its pre-development wetland conditions. A detailed analysis was preformed to derive a restoration plan that will achieve this goal. As required by the Water Resources Development Act (WRDA) 2000, the US Army Corps of Engineers (USACE) is required to ensure that no component of CERP results in an effective taking of land by adversely impacting the level of flood protection of adjacent landowners. To ensure the current level of flood protection is maintained, a hydrologic model was developed to assess the potential for flooding and help with the refinement of the proposed flood mitigation features. The USACE physically-based Gridded Sub-Surface Hydrologic Analysis (GSSHA) model was selected for this effort. The GSSHA model simulates fully coupled rainfall distribution, extraction, retention, overland flow, and one dimensional channel flow. The GSSHA model also has the capability of developing inset sub-models within the boundaries of a larger model domain (telescopic refinement) which allows for high resolution analysis of the hydrologic process being simulated. The inclusion of overland flow rating curves allowed critical hydraulic elements to be simulated with a reasonable model resolution.
The models were developed from existing and design data, and initially populated with parameter values from a previous hydrodynamic modeling effort. Parameters were then tuned to observed stage data using the Secant Levenberg-Marquardt (SLM) method, a nonlinear least squares minimization computer-based local search method. The calibrated model is capable of reproducing canal flows, canal stages, and overland stages with very high Nash Sutcliffe Forecast Efficiencies, generally 0.9 or higher. Subsequent uncertainty analysis allowed water stages to be estimated with 95% certainty.
The water level results and the uncertainty analysis allowed for the design refinement of the proposed flood mitigation features. The hydrologic models and analysis demonstrated that some of these features were either unnecessary or over-designed with respect to the original design.
C1 [Weston, David M.; Graulau-Santiago, Jaime A.] US Army, Adelphi, MD 20483 USA.
[Skahill, Brian E.; Downer, Charles W.; Pradhan, Nawa; Byrd, Aaron R.] US Army, Engn Res & Dev Ctr, Coastal & Hydraul Lab, Adelphi, MD 20483 USA.
RP Weston, DM (reprint author), US Army, Adelphi, MD 20483 USA.
NR 10
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC CIVIL ENGINEERS
PI NEW YORK
PA UNITED ENGINEERING CENTER, 345 E 47TH ST, NEW YORK, NY 10017-2398 USA
BN 978-0-7844-7916-2
PY 2015
BP 1500
EP 1511
PG 12
WC Engineering, Civil; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA BG8ZE
UT WOS:000392856300147
ER
PT J
AU Ramos, K
Gibson, S
Kavvas, LM
Heath, R
Sharp, J
AF Ramos, Kervi
Gibson, Stanford
Kavvas, Levent M.
Heath, Ronnie
Sharp, Jeremy
BE Karvazy, K
Webster, VL
TI Estimating Bed-Load Advection And Dispersion Coefficients With The
Method Of Moments
SO World Environmental and Water Resources Congress 2015: Floods, Droughts,
and Ecosystems
LA English
DT Proceedings Paper
CT World Environmental and Water Resources Congress
CY MAY 17-21, 2015
CL Austin, TX
SP Amer Soc Civil Engineers, Environm and Water Resources Inst
ID TRANSPORT
AB The Advection Dispersion (AD) equation is commonly used to simulate solute, wash load, and even suspended load transport, but is rarely applied to bed load. The obstacle to applying AD equation to bed load transport is empirical; it is challenging to estimate the advection and diffusion coefficients. This paper applies the method of moments to a flume experiment to compute the AD bed load coefficients.
Five colors of otherwise identical sand were introduced into an equilibrium sediment flume in sequence. After the experiment, surface, bed samples were collected along the length of the flume and sieved into eight-grain classes. Color distributions of each sample and each grain class were computed with image analysis. Longitudinal Probability Mass Function (PMF) of each color and each grain class were computed from these data. The method of moments was applied to the PMF of the particle displacements, where the advection coefficient was the temporal derivative of the first moment of each color and, the diffusion coefficient was defined as the temporal derivative of the variance. In this paper, advection and dispersion coefficients are computed for coarse sand material that consists of mean diameter of 1.3mm
C1 [Ramos, Kervi; Gibson, Stanford] US Army, Corps Engineers, Hydrol Engn Ctr, Inst Water Resources, 609 Second St, Davis, CA 95616 USA.
[Kavvas, Levent M.] Univ Calif Davis, Dept Civil & Environm Engn, Davis, CA 95616 USA.
[Heath, Ronnie; Sharp, Jeremy] US Army, Corps Engineers, Engn Res & Dev Ctr, Costal & Hydraul Lab, Vicksburg, MS 39180 USA.
RP Ramos, K (reprint author), US Army, Corps Engineers, Hydrol Engn Ctr, Inst Water Resources, 609 Second St, Davis, CA 95616 USA.
EM Kervi.Ramos@usace.mil; Stanford.Gibson@usace.army.mil;
leventkavvas@sbcglobal.net; Ronald.E.Heath@erdc.dren.mil;
Jeremy.Sharp@usace.army.mil
FU US Army Corps of Engineers' Flood; Coastal Storm Damage Reduction RD
Program
FX This work was funded by the US Army Corps of Engineers' Flood and
Coastal Storm Damage Reduction R&D Program. Glen Lischeske sieved the
samples and conducted the image analysis for this experiment.
NR 9
TC 2
Z9 2
U1 0
U2 0
PU AMER SOC CIVIL ENGINEERS
PI NEW YORK
PA UNITED ENGINEERING CENTER, 345 E 47TH ST, NEW YORK, NY 10017-2398 USA
BN 978-0-7844-7916-2
PY 2015
BP 1736
EP 1741
PG 6
WC Engineering, Civil; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA BG8ZE
UT WOS:000392856300169
ER
PT J
AU Dunn, CN
Baker, PR
AF Dunn, Christopher N.
Baker, Penni R.
BE Karvazy, K
Webster, VL
TI Converting Real-Time Water Management Models for Use in Water Resources
Studies
SO World Environmental and Water Resources Congress 2015: Floods, Droughts,
and Ecosystems
LA English
DT Proceedings Paper
CT World Environmental and Water Resources Congress
CY MAY 17-21, 2015
CL Austin, TX
SP Amer Soc Civil Engineers, Environm and Water Resources Inst
AB The U.S. Army Corps of Engineers (USACE) has been tasked to complete project studies more quickly without sacrificing model fidelity and to shift to a watershed and systems-based approach for decision making that incorporates risk analysis. These requirements are central to the USACE Civil Works and Planning Transformation Objectives. While tools exist to address these requirements, those tools have not been universally adopted. After the 2010 and 2011 floods, USACE initiated a plan to build real-time Corps Water Management System (CWMS) watersheds (212) throughout the Nation where USACE has a water management responsibility. One of the key reasons USACE management accepted the plan was that construction of CWMS models benefited other USACE mission areas. One benefit was that the CWMS models could be readily converted to planning models. Preliminary results indicated that the planning process could be shortened significantly if CWMS models were available early in the planning process. USACE performed a detailed study of three basins where CWMS models were converted to HEC-WAT (Watershed Analysis Tools) models. This paper will summarize the study and indicate that starting with CWMS watersheds; significant efficiencies are created thereby supporting the USACE goal of streamlining the planning process while still using detailed modeling.
C1 [Dunn, Christopher N.; Baker, Penni R.] US Army Corps Engineers, Hydrol Engn Ctr, Inst Water Resources, 609 Second St, Davis, CA 95616 USA.
RP Dunn, CN (reprint author), US Army Corps Engineers, Hydrol Engn Ctr, Inst Water Resources, 609 Second St, Davis, CA 95616 USA.
EM christopher.n.dunn@usace.army.mil; penni.r.baker@usace.army.mil
NR 7
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC CIVIL ENGINEERS
PI NEW YORK
PA UNITED ENGINEERING CENTER, 345 E 47TH ST, NEW YORK, NY 10017-2398 USA
BN 978-0-7844-7916-2
PY 2015
BP 2091
EP 2100
PG 10
WC Engineering, Civil; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA BG8ZE
UT WOS:000392856300206
ER
PT J
AU Manous, JD
AF Manous, Joe D., Jr.
BE Karvazy, K
Webster, VL
TI Critical Infrastructure - Preparing for the "Long Haul"
SO World Environmental and Water Resources Congress 2015: Floods, Droughts,
and Ecosystems
LA English
DT Proceedings Paper
CT World Environmental and Water Resources Congress
CY MAY 17-21, 2015
CL Austin, TX
SP Amer Soc Civil Engineers, Environm and Water Resources Inst
AB Critical infrastructure and sustainability have become key terms within the infrastructure design and governance communities over the past decade. This paper seeks to address issues related to sustainability and engineering design professionals by identifying key areas of need required from practitioners and academicians to chart a course for the long term.
The 2011 terrorist attacks on the United States galvanized discussion on critical infrastructure and, as importantly, provided funding to explore new ideas and methods. The consequences of Hurricanes Katrina and Rita in 2005 further shaped these discussions with an increased focus on water infrastructure. While additional "events" have facilitated the development of new ideas, academia has also responded by creating new courses and fields of study. Although these efforts are important and moving forward, they are in their infancy.
It is important to recognize that while efforts to develop a disciplinary field in these areas have begun, the efforts are independent and lack consistency of direction. There is a need for national-level leadership, but the source of such leadership is not clear.
C1 [Manous, Joe D., Jr.] US Army Corps Engineers, Inst Water Resources, 7701 Telegraph Rd, Alexandria, VA 22315 USA.
RP Manous, JD (reprint author), US Army Corps Engineers, Inst Water Resources, 7701 Telegraph Rd, Alexandria, VA 22315 USA.
EM Joe.Manous@usace.army.mil
NR 12
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC CIVIL ENGINEERS
PI NEW YORK
PA UNITED ENGINEERING CENTER, 345 E 47TH ST, NEW YORK, NY 10017-2398 USA
BN 978-0-7844-7916-2
PY 2015
BP 2293
EP 2299
PG 7
WC Engineering, Civil; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA BG8ZE
UT WOS:000392856300226
ER
PT J
AU Fleming, PEMJ
Duren, PEA
AF Fleming, Matthew J. P. E.
Duren, Angela P. E.
BE Karvazy, K
Webster, VL
TI Stochastic Hydrologic Simulation for Extension of Reservoir Pool Stage
Frequency Curves
SO World Environmental and Water Resources Congress 2015: Floods, Droughts,
and Ecosystems
LA English
DT Proceedings Paper
CT World Environmental and Water Resources Congress
CY MAY 17-21, 2015
CL Austin, TX
SP Amer Soc Civil Engineers, Environm and Water Resources Inst
AB A reservoir pool stage frequency curve, including an estimate of the 90-percent confidence limits, is required from the hydrologic analysis for a dam safety study. This information, in combination with estimates of potential dam failure scenarios, is used as a basis for estimating risk (which is comprised of the probability of occurrence and the associated consequences). In general, the pool stage frequency curve must be extended to peak elevations not yet experienced in the reservoir, such as the peak pool elevation generated by the Probable Maximum Flood (PMF) event. The pool stage frequency curve is used, along with hydraulic and consequence modeling, to estimate the damage and life loss for various possible failure modes of a dam. Dams are ranked in a priority order based on the amount of damage/life loss and the probability of failure. Extending the reservoir pool stage frequency curve out to the peak elevations not yet experienced by the reservoir is challenging due to the assumptions and uncertainties of routing synthetic events, including the PMF, through the reservoir. Due to unavailable tools or the inaccessibility of existing tools, the probabilities and associated uncertainties of the parameters and assumptions that is required for determining the peak pool elevation of a synthetic event are generally not accounted for in a pool stage frequency curve. In most cases, the exceedance probability assigned to the balanced hydrograph is also applied to a computed peak stage (with no accounting for the probability of the input parameters combined with the corresponding antecedent condition). New tools are under development at the Hydrologic Engineering Center (CEIWR-HEC) that provides the capability to evaluate these uncertainties in model assumptions and parameters.
C1 [Fleming, Matthew J. P. E.] US Army Corps Engineers, Hydrol Engn Ctr, Inst Water Resources, Hydrol & Hydraul Technol Div, 609 Second St, Davis, CA 95616 USA.
[Duren, Angela P. E.] US Army Corps Engineers, Portland, OR 97209 USA.
RP Fleming, PEMJ (reprint author), US Army Corps Engineers, Hydrol Engn Ctr, Inst Water Resources, Hydrol & Hydraul Technol Div, 609 Second St, Davis, CA 95616 USA.
EM matthew.j.fleming@usace.army.mil
NR 3
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC CIVIL ENGINEERS
PI NEW YORK
PA UNITED ENGINEERING CENTER, 345 E 47TH ST, NEW YORK, NY 10017-2398 USA
BN 978-0-7844-7916-2
PY 2015
BP 2648
EP 2657
PG 10
WC Engineering, Civil; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA BG8ZE
UT WOS:000392856300260
ER
PT J
AU Cap, A
Hunt, BJ
AF Cap, A.
Hunt, B. J.
TI The pathogenesis of traumatic coagulopathy
SO ANAESTHESIA
LA English
DT Review
ID ACTIVATED PROTEIN-C; DISSEMINATED INTRAVASCULAR COAGULATION;
LIFE-THREATENING HEMORRHAGE; FRESH WHOLE-BLOOD; 1ST 24 HOURS; MASSIVE
TRANSFUSION; TRANEXAMIC ACID; HEMOSTATIC RESUSCITATION; MAJOR TRAUMA;
ROTATION THROMBELASTOGRAPHY
AB Over the last 10years, the management of major haemorrhage in trauma patients has changed radically. This is mainly due to the recognition that many patients who are bleeding when they come in to the emergency department have an established coagulopathy before the haemodilution effects of fluid resuscitation. This has led to the use of new terminology: acute traumatic coagulopathy, acute coagulopathy of trauma shock or trauma-induced coagulopathy. The recognition of acute traumatic coagulopathy is important, because we now understand that its presence is a prognostic indicator, as it is associated with poor clinical outcome. This has driven a change in clinical management, so that the previous approach of maintaining an adequate circulating volume and oxygen carrying capacity before, as a secondary event, dealing with coagulopathy, has changed to haemostatic resuscitation as early as possible. While there is as yet no universally accepted assay or definition, many experts use prolongation of the prothrombin time to indicate that there is, indeed, a coagulopathy. Hypoxia, acidosis and hypothermia and hormonal, immunological and cytokine production, alongside consumption and blood loss, and the dilutional effects of resuscitation may occur to varying extents depending on the type of tissue damaged, the type and extent of injury, predisposing to, or amplifying, activation of coagulation, platelets, fibrinolysis. These are discussed in detail within the article.
C1 [Cap, A.] US Army, Med Corps, Sam Houston, TX USA.
[Cap, A.] Uniformed Serv Univ Hlth Sci, Blood Res Program, US Army Inst Surg Res, Sam Houston, TX USA.
[Hunt, B. J.] Guys & St Thomas NHS Fdn Trust, Dept Haematol, London, England.
[Hunt, B. J.] Guys & St Thomas NHS Fdn Trust, Dept Pathol, London, England.
[Hunt, B. J.] Guys & St Thomas NHS Fdn Trust, Dept Lupus, London, England.
RP Hunt, BJ (reprint author), Guys & St Thomas NHS Fdn Trust, Dept Haematol, London, England.
EM beverley.hunt@gstt.nhs.uk
NR 92
TC 18
Z9 19
U1 1
U2 23
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0003-2409
EI 1365-2044
J9 ANAESTHESIA
JI Anaesthesia
PD JAN
PY 2015
VL 70
SU 1
SI SI
DI 10.1111/anae.12914
PG 9
WC Anesthesiology
SC Anesthesiology
GA AU8JU
UT WOS:000345843500015
PM 25440402
ER
PT J
AU Wilkinson, JP
Boyd, T
Hagen, B
Maksym, T
Pegau, S
Roman, C
Singh, H
Zabilansky, L
AF Wilkinson, J. P.
Boyd, T.
Hagen, B.
Maksym, T.
Pegau, S.
Roman, C.
Singh, H.
Zabilansky, L.
TI Detection and quantification of oil under sea ice: The view from below
SO COLD REGIONS SCIENCE AND TECHNOLOGY
LA English
DT Article
DE Arctic; Oil spill; Sea ice; Oil detection; Sonar; Camera
AB Traditional measures for detecting oil spills in the open-ocean are both difficult to apply and less effective in ice-covered seas. In view of the increasing levels of commercial activity in the Arctic, there is a growing gap between the potential need to respond to an oil spill in Arctic ice-covered waters and the capability to do so. In particular, there is no robust operational capability to remotely locate oil spilt under or encapsulated within sea ice. To date, most research approaches the problem from on or above the sea ice, and thus they suffer from the need to 'see' through the ice and overlying snow. Here we present results from a large-scale tank experiment which demonstrate the detection of oil beneath sea ice, and the quantification of the oil layer thickness is achievable through the combined use of an upward-looking camera and sonar deployed in the water column below a covering of sea ice. This approach using acoustic and visible measurements from below is simple and effective, and potentially transformative with respect to the operational response to oil spills in the Arctic marine environment. These results open up a new direction of research into oil detection in ice-covered seas, as well as describing a new and important role for underwater vehicles as platforms for oil-detecting sensors under Arctic sea ice. (C) 2014 The Authors. Published by Elsevier B.V.
C1 [Wilkinson, J. P.] British Antarctic Survey, Cambridge CB3 0ET, England.
[Boyd, T.; Hagen, B.] Scottish Assoc Marine Sci, Oban PA37 1QA, Argyll, Scotland.
[Maksym, T.; Singh, H.] Woods Hole Oceanog Inst, Woods Hole, MA 02543 USA.
[Pegau, S.] Oil Spill Recovery Inst, Cordova, AK USA.
[Roman, C.] Univ Rhode Isl, Kingston, RI 02881 USA.
[Zabilansky, L.] Cold Reg Res Lab, Hanover, NH USA.
RP Wilkinson, JP (reprint author), British Antarctic Survey, High Cross Madingley Rd, Cambridge CB3 0ET, England.
EM jpw28@bas.ac.uk
FU Prince William Sound Oil Spill Recovery Institute (OSRI) [11-10-09]; EU
[265863]
FX This work was funded through a competitive grant for the detection of
oil under ice obtained from Prince William Sound Oil Spill Recovery
Institute (OSRI) (11-10-09). Additional funding/resources was obtained
through the EU FP7 funded ACCESS programme (Grant Agreement no. 265863).
NR 25
TC 1
Z9 1
U1 5
U2 38
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-232X
EI 1872-7441
J9 COLD REG SCI TECHNOL
JI Cold Reg. Sci. Tech.
PD JAN
PY 2015
VL 109
BP 9
EP 17
DI 10.1016/j.coldregions.2014.08.004
PG 9
WC Engineering, Environmental; Engineering, Civil; Geosciences,
Multidisciplinary
SC Engineering; Geology
GA AU5LG
UT WOS:000345647900002
ER
PT J
AU Zhang, LL
Jasa, J
Gazonas, G
Jerusalem, A
Negahban, M
AF Zhang, Lili
Jasa, John
Gazonas, George
Jerusalem, Antoine
Negahban, Mehrdad
TI Extracting continuum-like deformation and stress from molecular dynamics
simulations
SO COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING
LA English
DT Article
DE Molecular dynamics; Multi-scale; Deformation; Deformation gradients;
Stress; Minimization
ID ATOMIC-LEVEL STRESS; POTASSIUM CHANNEL; SYSTEM EQUIVALENCE; VIRIAL
STRESS; DEFINITIONS; TENSOR; MD
AB We present methods that use results from molecular dynamics (MD) simulations to construct continuum parameters, such as deformation gradient and Cauchy stress, from all or any part of an MD system. These parameters are based on the idea of minimizing the difference between MD measures for deformation and traction and their continuum counterparts. The procedures should be applicable to non-equilibrium and inhomogeneous systems, and to any part of a system, such as a polymer chain. The resulting procedures provide methods to obtain first and higher order deformation gradients associated with any subset of the MD system, and associated expressions for the Cauchy and nominal stresses. As these procedures are independent of the type of interactions, they can be used to study any MD simulation in a manner consistent with continuum mechanics and to extract information exploitable at the continuum scale to help construct continuum-level constitutive models. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Jasa, John; Negahban, Mehrdad] Univ Nebraska, Dept Mech & Mat Engn, Lincoln, NE 68588 USA.
[Gazonas, George] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Zhang, Lili; Jerusalem, Antoine] Univ Oxford, Dept Engn Sci, Oxford OX1 3PJ, England.
RP Negahban, M (reprint author), Univ Nebraska, W311 NH, Lincoln, NE 68588 USA.
EM mnegahban@unl.edu
OI Gazonas, George/0000-0002-2715-016X; Jerusalem,
Antoine/0000-0001-5026-8038
FU US Army Research Laboratory [W911NF-11-D-0001-0094]; European Research
Council under the European Union's Seventh Framework Program (FP7)/ERC
[306587]; Undergraduate Creative Activities and Research Experience
(UCARE) program at the University of Nebraska-Lincoln
FX The research has been partially supported by the US Army Research
Laboratory through Contract Number W911NF-11-D-0001-0094. Lili Zhang and
Antoine Jerusalem acknowledge funding from the European Research Council
under the European Union's Seventh Framework Program (FP7 2007-2013)/ERC
Grant Agreement No. 306587. John Jasa would like to acknowledge the
support of the Undergraduate Creative Activities and Research Experience
(UCARE) program at the University of Nebraska-Lincoln.
NR 39
TC 0
Z9 0
U1 5
U2 32
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0045-7825
EI 1879-2138
J9 COMPUT METHOD APPL M
JI Comput. Meth. Appl. Mech. Eng.
PD JAN 1
PY 2015
VL 283
BP 1010
EP 1031
DI 10.1016/j.cma.2014.10.018
PG 22
WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary
Applications; Mechanics
SC Engineering; Mathematics; Mechanics
GA AU8PM
UT WOS:000345858700042
ER
PT J
AU Ananworanich, J
Mellors, JW
AF Ananworanich, Jintanat
Mellors, John W.
TI A cure for HIV: what will it take?
SO CURRENT OPINION IN HIV AND AIDS
LA English
DT Editorial Material
ID LATENT RESERVOIR; CCR5
C1 [Ananworanich, Jintanat] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
[Ananworanich, Jintanat] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
[Mellors, John W.] Univ Pittsburgh, Pittsburgh, PA USA.
RP Ananworanich, J (reprint author), US Mil HIV Res Program, 6720A Rockledge Dr,Suite 400, Bethesda, MD 20817 USA.
EM jananworanich@hivresearch.org
FU NICHD NIH HHS [R01HD080435-01]
NR 10
TC 3
Z9 3
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1746-630X
EI 1746-6318
J9 CURR OPIN HIV AIDS
JI Curr. Opin. HIV AIDS
PD JAN
PY 2015
VL 10
IS 1
BP 1
EP 3
DI 10.1097/COH.0000000000000125
PG 3
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA AU9TY
UT WOS:000345938600001
PM 25389807
ER
PT J
AU Ananworanich, J
Dube, K
Chomont, N
AF Ananworanich, Jintanat
Dube, Karine
Chomont, Nicolas
TI How does the timing of antiretroviral therapy initiation in acute
infection affect HIV reservoirs?
SO CURRENT OPINION IN HIV AND AIDS
LA English
DT Review
DE acute HIV infection; early antiretroviral therapy; HIV DNA; HIV
reservoir; replication-competent virus
ID CD4(+) T-CELLS; IMMUNE-RESPONSES; SAMHD1; PERSISTENCE; SUBSETS; VIREMIA;
DECAY; ESTABLISHMENT; DRIVEN; VIRUS
AB Purpose of review
The long-lived viral reservoir is a major obstacle to achieving a cure for HIV. Therapeutic strategies, such as early antiretroviral therapy (ART), may be a prerequisite to achieving long-term control of viral replication upon ART withdrawal.
Recent findings
HIV persistence is established early in acute HIV infection (AHI) with infection in long-lived memory CD4(+) T cells. Studies conducted in nonhuman primates have suggested that this could occur as early as 3 days postinfection; however, the timing in humans is uncertain. ART during AHI significantly restricts the HIV reservoirs as compared with later treatment. Early ART, particularly prior to the detection of HIV immunoglobulin M, may also reduce the contribution of the long-lived central memory CD4(+) T cells to the total HIV reservoir, a profile observed in individuals who naturally control HIV without ART.
Summary
It is clear that early ART has a greater impact in limiting the HIV reservoirs than later treatment. However, latently infected long-lived memory CD4(+) T cells persist in most early treated individuals. Therefore, additional interventions will likely be required to eliminate all cells capable of producing replication-competent virus but treatment in AHI may be the critical first step in containing the HIV reservoirs.
C1 [Ananworanich, Jintanat] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
[Ananworanich, Jintanat] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
[Dube, Karine] Univ N Carolina, Chapel Hill, NC USA.
[Chomont, Nicolas] Vaccine & Gene Therapy Inst Florida, Port St Lucie, FL USA.
RP Ananworanich, J (reprint author), US Mil HIV Res Program, 6720A Rockledge Dr,Suite 400, Bethesda, MD 20817 USA.
EM Jananworanich@hivresearch.org
FU amfAR (ARCHE) [108687-54, 108928-56]; National Institutes of Health
[1R21 AI113096-01, 1U19AI096109]; National Institute of Allergy and
Infectious Diseases [R01HD080435-01]; CARE - Collaboratory of AIDS
Researchers for Eradication [U19AI096113]
FX The given work was supported in part by grants to N.C. from the amfAR
(ARCHE grants 108687-54 and 108928-56), the National Institutes of
Health (1R21 AI113096-01 and 1U19AI096109 - DARE: Delaney AIDS research
enterprise to find a cure) and a grant to J.A. from the National
Institute of Allergy and Infectious Diseases (R01HD080435-01). This work
was also partly supported by the CARE - Collaboratory of AIDS
Researchers for Eradication (U19AI096113); David M. Margolis PI.
NR 44
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U1 0
U2 17
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1746-630X
EI 1746-6318
J9 CURR OPIN HIV AIDS
JI Curr. Opin. HIV AIDS
PD JAN
PY 2015
VL 10
IS 1
BP 18
EP 28
DI 10.1097/COH.0000000000000122
PG 11
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA AU9TY
UT WOS:000345938600004
PM 25415421
ER
PT J
AU Goetz, FA
Jeanes, E
Moore, ME
Quinn, TP
AF Goetz, Fred A.
Jeanes, Eric
Moore, Megan E.
Quinn, Thomas P.
TI Comparative migratory behavior and survival of wild and hatchery
steelhead (Oncorhynchus mykiss) smolts in riverine, estuarine, and
marine habitats of Puget Sound, Washington
SO ENVIRONMENTAL BIOLOGY OF FISHES
LA English
DT Article
DE Behavior; Migration; Oncorhynchus mykiss; Survival; Telemetry
ID ATLANTIC SALMON SMOLTS; BRITISH-COLUMBIA; SOCKEYE-SALMON; CHINOOK
SALMON; PACIFIC SALMON; DETECTION PROBABILITIES; MARKED ANIMALS;
NORTH-AMERICA; KEOGH RIVER; TROUT
AB Declines in the survival of steelhead (Oncorhynchus mykiss) populations in protected waters of Washington and British Columbia have drawn attention to the need for more information on migratory patterns and losses in river, estuary, and nearshore habitats. Accordingly, acoustic telemetry was used to quantify movements by wild and hatchery steelhead smolts released from 2006 to 2009 in the Green River, and tracked through Puget Sound, Washington. Survival varied by release group and migration segment but overall survival rates from release to the Strait of Juan de Fuca were 9.7 % for wild and 3.6 % for hatchery fish. These rates are low relative to similar studies on steelhead. Survival was higher for wild fish along all migration segments than hatchery-origin fish; the greatest loss for both groups coincided with the slowest travel rates as fish first entered the estuary and as they exited Puget Sound. Wild fish travelled faster than hatchery fish in the river (15.1 vs. 4.4 km/d) with the fastest travel in the lower river (41 vs. 20.2 km/d) and slowest immediately after release (3.7 vs. 2.4 km/d). The travel rates of wild and hatchery fish became progressively more similar over time: 15.4 vs. 10.6 km/d in the estuary, and 10.3 vs. 9.3 km/d in nearshore areas. Movement was primarily nocturnal in the river, nearly equal between day and night in the upper estuary, and predominately diurnal in the lower estuary and nearshore waters, with no difference between wild and hatchery fish. The migration in marine water showed an early offshore movement and a strong northward and westward orientation, and all fish exited the Strait of Juan de Fuca rather than the Strait of Georgia. The findings support research suggesting that declines in wild and hatchery steelhead populations may be caused primarily by factors in the early marine period.
C1 [Goetz, Fred A.] US Army Corps Engineers, Seattle, WA 98134 USA.
[Goetz, Fred A.; Quinn, Thomas P.] Univ Washington, Sch Aquat & Fishery Sci, Seattle, WA 98105 USA.
[Jeanes, Eric] R2 Resource Consultants, Redmond, WA 98052 USA.
[Moore, Megan E.] Natl Ocean & Atmospher Adm Fisheries, Resource Enhancement & Utilizat Technol Div, NW Fisheries Sci Ctr, Manchester, WA 98353 USA.
RP Goetz, FA (reprint author), US Army Corps Engineers, POB 3755, Seattle, WA 98134 USA.
EM fgoetz@comcast.net
FU Washington Department of Fish and Wildlife (WDFW); Seattle District US
Army Corps of Engineers (USACE); H. Mason Keeler Endowment; Steelhead
Trout Club of Washington (STC); King County Department of Natural
Resources (KCDNR); Seattle City Light (SCL); Seattle Aquarium (SA); NOAA
Fisheries; Pacific Ocean Shelf Tracking (POST); Hydrophone Data
Repository (HYDRA)
FX This study was supported by funding and/or in-kind assistance by the
Washington Department of Fish and Wildlife (WDFW), Seattle District US
Army Corps of Engineers (USACE), H. Mason Keeler Endowment to the
University of Washington, Steelhead Trout Club of Washington (STC), King
County Department of Natural Resources (KCDNR), Seattle City Light
(SCL), Seattle Aquarium (SA), NOAA Fisheries, Pacific Ocean Shelf
Tracking (POST), and Hydrophone Data Repository (HYDRA). This study was
reviewed and approved by the University of Washington's Institutional
Animal Care and Use Committee. We thank Bob Leland, Kelly Kiyohara, Pat
Michael, Brody Antipa, Pete Topping, and Deborah Feldman of the WDFW for
their efforts in project planning, smolt collection, hatchery rearing,
tagging, and receiver deployment; Hal Boynton, John Kelly, Ed Conroy and
other members of the STC for their enthusiasm and support; Kelly Andrews
(NOAA Fisheries), Ed Connor (SCL), John Blaine and Jim Devereaux (KCNDR)
for their assistance; Correigh Greene (NOAA), Shawn Larson and Jeff
Christiansen (SA), Chuck Ebel (USACE), Kurt Dobszinsky, Paul Winchell,
David Welch and Debbie Goetz for deployment of receivers, and Jose
Reyes-Tomassini for assistance with the AquaTracker program. We also
thank Jennifer Scheuerell, Chris Ewing, and Dawn Pucci (HYDRA) and Jose
Gimenez and Aswea Porter (POST) for data sharing and management, and
Jonathan Thar and Jim Bolger for helping expand the POST project to
Puget Sound.
NR 69
TC 2
Z9 2
U1 8
U2 47
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0378-1909
EI 1573-5133
J9 ENVIRON BIOL FISH
JI Environ. Biol. Fishes
PD JAN
PY 2015
VL 98
IS 1
BP 357
EP 375
DI 10.1007/s10641-014-0266-3
PG 19
WC Ecology; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA AU5CS
UT WOS:000345625400031
ER
PT J
AU Videen, G
Kocifaj, M
Sun, WB
Kai, K
Kawamoto, K
Horvath, H
Mishchenko, M
AF Videen, Gorden
Kocifaj, Miroslav
Sun, Wenbo
Kai, Kenji
Kawamoto, Kazuaki
Horvath, Helmuth
Mishchenko, Michael
TI Topical issue on optical particle characterization and remote sensing of
the atmosphere: Part I
SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER
LA English
DT Editorial Material
C1 [Videen, Gorden] US Army Res Lab, Adelphi, MD 20783 USA.
[Kocifaj, Miroslav] Slovak Acad Sci, Bratislava 84503, Slovakia.
[Sun, Wenbo] Sci Syst & Applicat Inc, Hampton, VA 23666 USA.
[Kai, Kenji] Nagoya Univ, Chikusa Ku, Nagoya, Aichi 4648601, Japan.
[Kawamoto, Kazuaki] Nagasaki Univ, Fac Environm Studies, Nagasaki, Japan.
[Horvath, Helmuth] Univ Vienna, Dept Phys, A-1090 Vienna, Austria.
[Mishchenko, Michael] NASA, Goddard Inst Space Studies, New York, NY 10025 USA.
RP Videen, G (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM Gorden.w.videen.civ@mail.mil; kocifaj@savba.sk; wenbo.sun-1@nasa.gov;
kai@info.human.nagoya-u.ac.jp; kazukawa@nagasaki-u.ac.jp;
Horvath5@login.univie.ac.at; michael.i.mishchenko@nasa.gov
RI Mishchenko, Michael/D-4426-2012
NR 16
TC 2
Z9 2
U1 1
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-4073
EI 1879-1352
J9 J QUANT SPECTROSC RA
JI J. Quant. Spectrosc. Radiat. Transf.
PD JAN
PY 2015
VL 150
SI SI
BP 1
EP 2
DI 10.1016/j.jqsrt.2014.09.008
PG 2
WC Optics; Spectroscopy
SC Optics; Spectroscopy
GA AU8AQ
UT WOS:000345819600001
ER
PT J
AU Pan, YL
AF Pan, Yong-Le
TI Detection and characterization of biological and other organic-carbon
aerosol particles in atmosphere using fluorescence
SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER
LA English
DT Article
ID LASER-INDUCED FLUORESCENCE; MULTIPHOTON-EXCITED FLUORESCENCE;
CROSS-SECTIONS; POTENTIAL INTERFERENCES; INTRINSIC FLUORESCENCE;
EXCITATION WAVELENGTHS; UV FLUORESCENCE; SERUM-ALBUMIN; FUNGAL SPORES;
BIOAEROSOLS
AB This paper offers a brief review on the detection and characterization of biological and other organic-carbon (OC) aerosol particles in atmosphere using laser-induced-fluorescence (LIF) signatures, It focuses on single individual particles or aggregates in the micron and supermicron size range when they are successively drawn through the interrogation volume of a point detection system. Related technologies for these systems that have been developed in last two decades are also discussed. These results should provide a complementary view for studying atmospheric aerosol particles, particularly bioaerosol and OC aerosol particles from other analytical technologies. Published by Elsevier Ltd.
C1 US Army Res Lab, Adelphi, MD 20783 USA.
RP Pan, YL (reprint author), US Army Res Lab, Adelphi, MD 20783 USA.
EM yongle.pan.civ@mail.mil
FU U.S. Army Research Laboratory mission funds
FX Thank for the U.S. Army Research Laboratory mission funds. Thank Carol
Johnson and Water Bailey for assisting editing this article.
NR 105
TC 15
Z9 15
U1 1
U2 57
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-4073
EI 1879-1352
J9 J QUANT SPECTROSC RA
JI J. Quant. Spectrosc. Radiat. Transf.
PD JAN
PY 2015
VL 150
SI SI
BP 12
EP 35
DI 10.1016/j.jqsrt.2014.06.007
PG 24
WC Optics; Spectroscopy
SC Optics; Spectroscopy
GA AU8AQ
UT WOS:000345819600003
ER
PT J
AU Zubko, E
Shkuratov, Y
Videen, G
AF Zubko, Evgenij
Shkuratov, Yuriy
Videen, Gorden
TI Effect of morphology on light scattering by agglomerates
SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER
LA English
DT Article
DE Light scattering; Discrete dipole approximation; Agglomerate particles
ID DISCRETE-DIPOLE APPROXIMATION; INTERSTELLAR GRAINS; OPTICAL-CONSTANTS;
AEROSOL-PARTICLES; DUST; RADAR; MATRICES
AB Using the discrete dipole approximation (DDA), we compute light scattering from irregularly shaped particles with three different types of agglomerate morphologies. The packing density of materials in the model particles spans the range from 0.169 through 0.336. We investigate four different refractive indices m=1.313 + 0i, 1.6+0.0005i, 1.5+0.1i, and 1.855+0.45i, which are representative of various cosmic and terrestrial materials in the visible. In each case, we consider a wide range of size parameters that makes it possible to average the light-scattering response over particle size with a power-law size distribution. We find that despite noticeable differences in particle morphology, their light-scattering responses are remarkably similar; the difference in light scattering often does not exceed the error bars occurring in laboratory measurements of micronsized particles. On the contrary, the impact of refractive index and size distribution on light scattering appears to be much stronger compared with the morphology of complex, agglomerate particles. This finding may simplify considerably the interpretation of photo-polarimetric observations of atmospheric aerosols, cosmic dust particles, etc., because the precise specification of target-particle shape is unnecessary for the analysis. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Zubko, Evgenij; Shkuratov, Yuriy] Kharkov Natl Univ, Inst Astron, UA-61022 Kharkov, Ukraine.
[Videen, Gorden] US Army Res Lab, Adelphi, MD 20783 USA.
[Videen, Gorden] Space Sci Inst, Boulder, CO 80301 USA.
RP Zubko, E (reprint author), Kharkov Natl Univ, Inst Astron, 35 Sumskaya St, UA-61022 Kharkov, Ukraine.
EM evgenij.s.zubko@gmail.com
FU NASA Lunar Advanced Science and Exploration Research Program
[NNX11AB25G]; NASA Outer Planets Research Program [NNX10AP93G]
FX This work was partially supported by NASA Lunar Advanced Science and
Exploration Research Program (Contract NNX11AB25G) and NASA Outer
Planets Research Program (Contract NNX10AP93G). We thank two anonymous
referees for their constructive reviews.
NR 28
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U1 0
U2 18
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-4073
EI 1879-1352
J9 J QUANT SPECTROSC RA
JI J. Quant. Spectrosc. Radiat. Transf.
PD JAN
PY 2015
VL 150
SI SI
BP 42
EP 54
DI 10.1016/j.jqsrt.2014.06.023
PG 13
WC Optics; Spectroscopy
SC Optics; Spectroscopy
GA AU8AQ
UT WOS:000345819600005
ER
PT J
AU Videen, G
Zubko, E
Sun, WB
Shkuratov, Y
Yuffa, A
AF Videen, Gorden
Zubko, Evgenij
Sun, Wenbo
Shkuratov, Yuriy
Yuffa, Alex
TI Mixing rules and morphology dependence of the scatterer
SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER
LA English
DT Article
DE Bruggeman; Mixing rules; Morphology; Agglomerate; Agglomerated debris;
Light scattering
ID EFFECTIVE-MEDIUM APPROXIMATIONS; DISCRETE-DIPOLE APPROXIMATION;
OPTICAL-PROPERTIES; COMETARY DUST; LIGHT-SCATTERING; SPHERICAL
INCLUSIONS; COMPOSITE SPHERE; SOLAR-RADIATION; BLACK CARBON; PARTICLES
AB We use the discrete dipole algorithm (DDA) to calculate the light-scattering properties from arbitrarily shaped, heterogeneous agglomerated debris particles to study the performance of effective medium approximations. The homogenization of the material properties of the particle has little effect on the orientation-averaged intensity phase function. However, there are some differences in the polarization response. While the structure of the linear-polarization response is not significantly different between the homogeneous and heterogeneous cases, the amplitude of the polarization tends to show a dependence on particle heterogeneity. The Bruggeman mixing rule tends to reproduce the heterogeneous results marginally better than using the average of two distributions of the individual homogeneous components. In addition to the irregularly shaped particles, we also calculated scattering properties of equivalent-volume, homogeneous spheres. As expected, the errors due to assuming homogeneous particles are overwhelmed by those introduced by assuming the irregularly shaped particle may be replaced by an equivalent spherical particle. Published by Elsevier Ltd.
C1 [Videen, Gorden; Yuffa, Alex] Army Res Lab, Adelphi, MD 20783 USA.
[Videen, Gorden] Space Sci Inst, Boulder, CO 80301 USA.
[Zubko, Evgenij; Shkuratov, Yuriy] Kharkov Natl Univ, Inst Astron, UA-61022 Kharkov, Ukraine.
[Sun, Wenbo] Sci Syst & Applicat Inc, Hampton, VA 23666 USA.
RP Videen, G (reprint author), Army Res Lab, Adelphi, MD 20783 USA.
EM gorden.w.videen.civ@mail.mil
RI Richards, Amber/K-8203-2015; Yuffa, Alex/B-5498-2014
OI Yuffa, Alex/0000-0002-3600-1131
FU NASA Glory fund [09-GLORY09-0027]; NASA CLARREO mission
FX This work was supported by NASA Glory fund 09-GLORY09-0027. Wenbo Sun
also was supported by NASA CLARREO mission and he thanks Bruce A.
Wielicld and Rosemary R. Baize for this support.
NR 45
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U1 0
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-4073
EI 1879-1352
J9 J QUANT SPECTROSC RA
JI J. Quant. Spectrosc. Radiat. Transf.
PD JAN
PY 2015
VL 150
SI SI
BP 68
EP 75
DI 10.1016/j.jqsrt.2014.07.022
PG 8
WC Optics; Spectroscopy
SC Optics; Spectroscopy
GA AU8AQ
UT WOS:000345819600007
ER
PT J
AU Videen, G
Muinonen, K
AF Videen, Gorden
Muinonen, Karri
TI Light-scattering evolution from particles to regolith
SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER
LA English
DT Article
DE Light scattering; Agglomerate; Polarization; Coherent backscattering;
Radiative transfer; Opposition effect
ID COMETARY DUST; COHERENT BACKSCATTERING; PARTICULATE SURFACES;
SPHERICAL-PARTICLES; AGGREGATE PARTICLES; NUMERICAL-SOLUTION; PHASE
ANGLES; RANDOM-MEDIA; POLARIZATION; MATRIX
AB The radiative-transfer coherent-backscattering (RT-CB) model is unique among light-scattering methodologies as it can be used to calculate accurate light-scattering properties of sparsely populated particle volumes with sizes ranging from subwavelength to infinity. We use the RT-CB model to examine the evolution of light-scattering properties as a volume of particles increases from wavelength-sized to several hundreds of wavelengths. We examine the evolution of light-scattering intensity phase function and polarization, as well as linear and circular polarization ratios. We confirm the expected trends for backscattering features to shift to smaller phase angles as the volume increases. In addition, we also see the amplitude of these features increases to some maximum for volumes having size parameters kR similar to 100, before decaying to less than half this amplitude as their volumes approach infinity. Published by Elsevier Ltd.
C1 [Videen, Gorden] Army Res Lab, Adelphi, MD 20783 USA.
[Videen, Gorden] Space Sci Inst, Boulder, CO 80301 USA.
[Muinonen, Karri] Univ Helsinki, Dept Phys, FI-00014 Helsinki, Finland.
[Muinonen, Karri] Finnish Geodet Inst, FI-02431 Masala, Finland.
RP Videen, G (reprint author), Army Res Lab, Adelphi, MD 20783 USA.
EM gorden.w.videen.civ@mail.mil
FU ERC Advanced Grant [320773]; Academy of Finland [257966]; NASA Outer
Planets Research Program [NNX10AP93G]; NASA Lunar Advanced Science and
Exploration Research Program [NNX11AB25G]
FX Research funded, in part, by the ERC Advanced Grant no. 320773 entitled
"Scattering and Absorption of Electromagnetic Waves in Particulate
Media" (SAEMPL), the Academy of Finland (Contract 257966), NASA Outer
Planets Research Program (Contract NNX10AP93G), and NASA Lunar Advanced
Science and Exploration Research Program (Contract NNX11AB25G).
NR 46
TC 5
Z9 5
U1 1
U2 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-4073
EI 1879-1352
J9 J QUANT SPECTROSC RA
JI J. Quant. Spectrosc. Radiat. Transf.
PD JAN
PY 2015
VL 150
SI SI
BP 87
EP 94
DI 10.1016/j.jqsrt.2014.05.019
PG 8
WC Optics; Spectroscopy
SC Optics; Spectroscopy
GA AU8AQ
UT WOS:000345819600009
ER
PT J
AU Kocifaj, M
Videen, G
Klacka, J
AF Kocifaj, Miroslav
Videen, Gorden
Klacka, Jozef
TI Backscatter in a cloudy atmosphere as a lightning-threat indicator
SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER
LA English
DT Article
DE Charged water droplets; Water clouds; Electromagnetic scattering; Remote
sensing; Radar backscatter
ID ELECTROMAGNETIC-WAVES; CHARGED SPHERES; SCATTERING; CONSEQUENCES; DUST
AB We present a remote-sensing method for identifying electrically charged droplets in clouds. Our methodology utilizes the electromagnetic (EM) radiation backscattered by the cloud at multiple wavelengths. In general, the backscatter from collections of charged and neutral particles differs in Rayleigh regime. While a uniformly charged sphere can resonate with an incident EM radiation depending on electrostatic potential at the particle surface, the scatter by a neutral particle is governed by the Lorenz-Mie theory, thus resulting in different surface excitations. The effects of electric charges and other microphysical parameters on the electromagnetic interactions with particles are not easily separable. Because the spectral profile of the dielectric function for liquid water (or alternatively icy grains) is known, retrieval of net charges are possible based on the optical behavior of the backscattered EM signals. Such information can be used to determine charge build-up in the atmosphere, which is a condition for lightning. A basic configuration of a measuring system for lightning threats is discussed and described schematically. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Kocifaj, Miroslav] Slovak Acad Sci, ICA, Bratislava 84503, Slovakia.
[Kocifaj, Miroslav; Klacka, Jozef] Comenius Univ, Fac Math Phys & Informat, Bratislava 84248, Slovakia.
[Videen, Gorden] US Army, Res Lab, AMSRD ARL CI ES, Adelphi, MD 20783 USA.
RP Kocifaj, M (reprint author), Slovak Acad Sci, ICA, Dubravska Rd 9, Bratislava 84503, Slovakia.
EM kocifaj@savba.sk
FU Scientific Grant Agency VEGA [2/0002/12]; Slovak Research and
Development Agency [APVV-0177-10]
FX This work was partially supported by the Scientific Grant Agency VEGA,
Grant no. 2/0002/12 and by the Slovak Research and Development Agency
under Contract no: APVV-0177-10.
NR 25
TC 5
Z9 5
U1 2
U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-4073
EI 1879-1352
J9 J QUANT SPECTROSC RA
JI J. Quant. Spectrosc. Radiat. Transf.
PD JAN
PY 2015
VL 150
SI SI
BP 175
EP 180
DI 10.1016/j.jqsrt.2014.03.004
PG 6
WC Optics; Spectroscopy
SC Optics; Spectroscopy
GA AU8AQ
UT WOS:000345819600017
ER
PT J
AU McWilliams, B
Yu, J
Zavaliangos, A
AF McWilliams, Brandon
Yu, Jian
Zavaliangos, Antonios
TI Fully coupled thermal-electric-sintering simulation of electric field
assisted sintering of net-shape compacts
SO JOURNAL OF MATERIALS SCIENCE
LA English
DT Article
ID TEMPERATURE DISTRIBUTION; SPARK; POWDER; DISTRIBUTIONS; COMPOSITES;
COMPONENTS; TUNGSTEN; STRESS; MODEL
AB A fully coupled thermal-electric-sintering finite element model was developed and implemented to predict heterogeneous densification in net-shape compacts using electric field assisted sintering techniques (FAST). FAST is a single-step processing operation for producing bulk materials from powders, in which the powder is heated by the application of electric current under pressure. Previous modeling efforts on FAST have mostly considered the thermal-electric aspect of the problem and have largely neglected the sintering aspect of the problem. A new model was developed by integrating a phenomenological sintering model into a previously established thermal-electric finite element framework to predict the densification kinetics of the sample. The model was used to quantify the effect of specimen geometry on the evolution of thermoelectric gradients and resulting heterogeneous sintering kinetics during FAST processing of a conductive powder. It is shown that the new model which considers sintering kinetics and density-dependent properties provides a substantial increase in accuracy compared to thermal- electric only models. It is also shown that small changes in local resistance due to densification can greatly impact the distribution of thermoelectric gradients during the process, which are exacerbated by heterogeneous stress states induced by sample geometry. Experimental characterization of sintered specimens is used to provide qualitative validation of the model predictions.
C1 [McWilliams, Brandon; Yu, Jian] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, Aberdeen Proving Ground, MD 21005 USA.
[Zavaliangos, Antonios] Drexel Univ, Dept Mat Sci & Engn, Philadelphia, PA 19104 USA.
RP McWilliams, B (reprint author), US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, Aberdeen Proving Ground, MD 21005 USA.
EM brandon.a.mcwilliams.civ@mail.mil; jian.h.yu.civ@mail.mil;
azavalia@coe.drexel.edu
NR 32
TC 5
Z9 5
U1 5
U2 34
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0022-2461
EI 1573-4803
J9 J MATER SCI
JI J. Mater. Sci.
PD JAN
PY 2015
VL 50
IS 2
BP 519
EP 530
DI 10.1007/s10853-014-8463-1
PG 12
WC Materials Science, Multidisciplinary
SC Materials Science
GA AU1WJ
UT WOS:000345407900002
ER
PT J
AU Weingarten, NS
Byrd, EFC
AF Weingarten, N. Scott
Byrd, Edward F. C.
TI Special quasirandom structures of alon
SO COMPUTATIONAL MATERIALS SCIENCE
LA English
DT Article
DE Aluminum oxynitride; Special quasirandom structures; Density functional
theory; Elastic constants
ID GENERALIZED GRADIENT APPROXIMATION; INITIO MOLECULAR-DYNAMICS;
TOTAL-ENERGY CALCULATIONS; AUGMENTED-WAVE METHOD; N-O SYSTEM; ALUMINUM
OXYNITRIDE; ELECTRONIC-PROPERTIES; ALN-AL2O3 SECTION; BASIS-SET; SPINEL
AB The crystal structure of Al23O27N5, which is an ideal stoichiometry of aluminum oxynitride (or alon), is a defect spinel in which a vacancy is present in the unit cell. Despite the lattice positions being fixed, the location of the vacancy and the positions of the five nitrogen atoms are not unique, presenting a challenge to the prediction of the crystal structure. This problem is analogous to random alloys, for which a technique has been developed to identify small scale simulation cells called special quasirandom structures (SQS). We present SQS for alon, and discuss the unique features of these structures for this material. We also modified the SQS methodology to identify the first cubic crystal structure for alon with the above stoichiometry. Published by Elsevier B.V.
C1 [Weingarten, N. Scott; Byrd, Edward F. C.] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
RP Weingarten, NS (reprint author), US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
EM neil.s.weingarten.civ@mail.mil
NR 31
TC 3
Z9 3
U1 1
U2 29
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0927-0256
EI 1879-0801
J9 COMP MATER SCI
JI Comput. Mater. Sci.
PD JAN
PY 2015
VL 96
BP 312
EP 318
DI 10.1016/j.commatsci.2014.09.021
PN A
PG 7
WC Materials Science, Multidisciplinary
SC Materials Science
GA AT4XU
UT WOS:000344946600045
ER
PT J
AU Bruhl, JC
Varma, AH
Johnson, WH
AF Bruhl, Jakob C.
Varma, Amit H.
Johnson, William H.
TI Design of composite SC walls to prevent perforation from missile impact
SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING
LA English
DT Article
DE Projectile impact; Composite structure; Concrete; Steel plate
ID AIRCRAFT ENGINE MISSILES; SPHERICAL-NOSE RODS; REINFORCED-CONCRETE;
SHEAR CONNECTORS; LOCAL DAMAGE; PROJECTILES; PENETRATION; TARGETS;
PLATES
AB This paper presents a three-step method for designing steel plate composite (SC) walls subjected to missile impact. This method can be used to compute the minimum required steel plate thickness for SC walls to prevent perforation due to missile impact. The design method was verified using the complete experimental database of 130 SC wall missile impact tests compiled as part of this research. The design method compares favorably with the observations and results from the experimental database and can be used within its range of applicability to design SC walls to prevent missile perforation. The paper also presents the development and benchmarking of 3D finite element models for predicting the behavior and local failure of SC walls subjected to missile impact. The models were benchmarked using test results from the experimental database and results were used to confirm the failure mechanism of SC walls subjected to missile impact. The benchmarked models were used to conduct analytical parametric studies to expand the database, and further verify the design method. The numerical modeling approach is recommended for future research and design of specific SC wall configurations to resist design basis missiles. Published by Elsevier Ltd.
C1 [Bruhl, Jakob C.] US Army, W Lafayette, IN 47907 USA.
[Bruhl, Jakob C.; Varma, Amit H.] Purdue Univ, Sch Civil Engn, W Lafayette, IN 47907 USA.
[Johnson, William H.] Bechtel Corp, Frederick, MD 21703 USA.
RP Bruhl, JC (reprint author), US Army, 550 Stadium Mall Dr, W Lafayette, IN 47907 USA.
EM jbruhl@purdue.edu; ahvarma@purdue.edu; whjohnson@bechtel.com
OI Bruhl, Jakob/0000-0002-1645-4520; Varma, Amit/0000-0001-7153-4681
NR 33
TC 18
Z9 18
U1 0
U2 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0734-743X
EI 1879-3509
J9 INT J IMPACT ENG
JI Int. J. Impact Eng.
PD JAN
PY 2015
VL 75
BP 75
EP 87
DI 10.1016/j.ijimpeng.2014.07.015
PG 13
WC Engineering, Mechanical; Mechanics
SC Engineering; Mechanics
GA AT7JB
UT WOS:000345111200008
ER
PT J
AU Feng, YZ
Siegmund, T
Habtour, E
Riddick, J
AF Feng, Yuezhong
Siegmund, Thomas
Habtour, Ed
Riddick, Jaret
TI Impact mechanics of topologically interlocked material assemblies
SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING
LA English
DT Article
DE Topologically interlocking material assemblies; Impact loading;
Ballistic limit; Residual velocity; Modeling and simulation
ID MATERIAL-PROPERTY SPACE; ENERGY-ABSORPTION; BALLISTIC IMPACT; DYNAMIC
FRAGMENTATION; COMPOSITE-MATERIALS; HYBRID MATERIALS; SHAPED ELEMENTS;
STEEL PLATES; PENETRATION; PRINCIPLE
AB The objective of the present study is to provide understanding of potential energy absorption and dissipation mechanisms and benefits of topologically interlocked material (TIM) assemblies under impact loading. The study is motivated by earlier findings that TIMs under low rate loading demonstrated attractive properties including the capability to arrest and localize cracks and to exhibit a quasi-ductile response even when the unit elements are made of brittle materials. It is hypothesized that TIMs due to their modularity would possess advantageous impact characteristics. In order to test this hypothesis, a series of computational experiments on the dynamic loading of TIMs are conducted. Results obtained in this study are presented for a planar TIM configuration based on a dense packing of tetrahedral unit elements to form an energy absorption layer. Finite element models are calibrated on samples fabricated using fused deposition modeling (FDM) additive manufacturing (AM). With employing the Lambert-Jonas formula to interpret the numerical data, it is demonstrated that TIMs can absorb more impact energy than conventional solid plates. An extended Lambert-Jonas model is defined such that accurate description of the impact response of TIMs is obtained. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Feng, Yuezhong; Siegmund, Thomas] Purdue Univ, Sch Mech Engn, W Lafayette, IN 47907 USA.
[Habtour, Ed; Riddick, Jaret] US Army Res Lab, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA.
RP Siegmund, T (reprint author), Purdue Univ, Sch Mech Engn, W Lafayette, IN 47907 USA.
EM siegmund@purdue.edu
OI Habtour, Ed/0000-0002-9083-9285; Siegmund, Thomas/0000-0001-8162-9609
FU Army Research Office grant Mechanics of Multiscale Energy Dissipation
(ARO) [W911 NF-12-1-0370]; National Science Foundation (N.S.F.)
FX The authors Y. Feng and T. Siegmund acknowledge funding by the Army
Research Office grant Mechanics of Multiscale Energy Dissipation (ARO
Grant No. W911 NF-12-1-0370) in Topologically Interlocked Materials-11.1
STIR, (Larry Russell Jr, Solid Mechanics, Program Manager). T. Siegmund
also acknowledges support from the National Science Foundation (N.S.F.)
while working at N.S.F.
NR 44
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Z9 9
U1 2
U2 27
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0734-743X
EI 1879-3509
J9 INT J IMPACT ENG
JI Int. J. Impact Eng.
PD JAN
PY 2015
VL 75
BP 140
EP 149
DI 10.1016/j.ijimpeng.2014.08.003
PG 10
WC Engineering, Mechanical; Mechanics
SC Engineering; Mechanics
GA AT7JB
UT WOS:000345111200013
ER
PT J
AU Thiagarajan, G
Kadambi, AV
Robert, S
Johnson, CF
AF Thiagarajan, Ganesh
Kadambi, Anirudha V.
Robert, Stephen
Johnson, Carol F.
TI Experimental and finite element analysis of doubly reinforced concrete
slabs subjected to blast loads
SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING
LA English
DT Article
DE Blast loading; Reinforced concrete slab; Experimental data; Finite
element simulation; High strength materials
ID NUMERICAL-SIMULATION; MATERIAL MODEL; PERFORATION
AB This paper presents research on the response and behavior of both high strength concrete (107 MPa) and normal strength concrete (27.6 MPa) slabs doubly reinforced with high strength low alloy vanadium (HSLA-V) reinforcement (VR) and conventional steel reinforcing bars (NR) subjected to explosive loads. Four types of reinforced concrete (RC) slabs namely High Strength Concrete (HSC) with HSLA-V Steel Reinforcing bars (HSC-VR), High Strength Concrete with Conventional Steel Reinforcing bars (HSC-NR), Normal Strength Concrete (NSC) with HSLA-V Steel Reinforcing bars (NSC-VR), and Normal Strength Concrete with Conventional Steel Reinforcing bars (NSC-NR) have been studied and compared both experimentally and numerically. The slabs were subjected to blast loads using a shock tube capable of generating both positive and negative phase pressures. Data collected during the dynamic experiments consisted of reflected pressure obtained from several pressure gages arranged along the perimeter of the test article and mid-span deflections captured from an accelerometer, a laser device, and high speed video. The numerical analysis was performed with the commercial program LS-DYNA using two material models. The concrete material models considered were Winfrith Concrete Model (WCM) and Concrete Damage Model Release 3 (CDMR3). Results from the numerical simulation are compared with the experimental values to determine material parameters and other finite element model related constraints. Mesh sensitivity and crack propagation studies were also conducted. From this study it was observed that CDMR3 and WCM can be used over a wider range of concrete compressive strengths. The advantages and disadvantages of using high strength materials are discussed. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Thiagarajan, Ganesh; Kadambi, Anirudha V.] Univ Missouri, Dept Civil Engn, Kansas City, MO 64110 USA.
[Robert, Stephen; Johnson, Carol F.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Thiagarajan, G (reprint author), Univ Missouri, Dept Civil Engn, 352 Flarsheim Hall,5100 Rockhill Rd, Kansas City, MO 64110 USA.
EM ganesht@umkc.edu
NR 34
TC 12
Z9 14
U1 7
U2 33
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0734-743X
EI 1879-3509
J9 INT J IMPACT ENG
JI Int. J. Impact Eng.
PD JAN
PY 2015
VL 75
BP 162
EP 173
DI 10.1016/j.ijimpeng.2014.07.018
PG 12
WC Engineering, Mechanical; Mechanics
SC Engineering; Mechanics
GA AT7JB
UT WOS:000345111200015
ER
PT J
AU Nilakantan, G
Merrill, RL
Keefe, M
Gillespie, JW
Wetzel, ED
AF Nilakantan, Gaurav
Merrill, Richard L.
Keefe, Michael
Gillespie, John W., Jr.
Wetzel, Eric D.
TI Experimental investigation of the role of frictional yarn pull-out and
windowing on the probabilistic impact response of kevlar fabrics
SO COMPOSITES PART B-ENGINEERING
LA English
DT Article
DE Aramid fiber; Fabrics/textiles; Impact behavior; Statistical
properties/methods
ID BALLISTIC IMPACT; ENERGY-ABSORPTION; WOVEN FABRICS; STRENGTH;
PERFORMANCE; BEHAVIOR; SINGLE
AB The probabilistic impact responses of single layer greige and scoured plain-weave Kevlar KM2 fabrics are experimentally studied. Single-layer, 101 cm x 101 cm fabric targets are mounted in a novel equilateral octagon (EO) fixture that leaves the principal yarns unclamped. A probabilistic velocity response (PVR) curve, which describes the probability of fabric penetration as a function of projectile impact velocity, is generated through a series of thirty impact tests using a spherical steel projectile impacted at velocities between 69 and 113 m/s. Additional experiments are conducted by impacting targets repeatedly at identical velocities, and comparing the resulting residual velocities of the penetrating projectiles. Fabric penetration in all cases is entirely accommodated by yarn pull-out and windowing, without any principal yarn failure at the impact site. The results indicate that frictional yarn sliding and pull-out are the primary energy dissipating mechanisms during these impact conditions. Controlled yarn pull-out experiments are conducted on the same greige and scoured fabrics to statistically characterize the yarn pull-out loads. Variability in pull-out forces in the greige fabrics are measurably higher than the variability in pull-out forces for the scoured fabrics, which correlates well with variability trends in the PVR and residual velocity ballistic experiments. Additional factors, such as yarn-projectile friction and differences in filament packing efficiency, are hypothesized to also contribute to the observed differences in the greige and scoured fabric impact responses. Published by Elsevier Ltd.
C1 [Nilakantan, Gaurav] Univ So Calif, Dept Chem Engn & Mat Sci, MC Gill Composites Ctr, Los Angeles, CA 90089 USA.
[Merrill, Richard L.; Wetzel, Eric D.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Keefe, Michael] Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA.
[Nilakantan, Gaurav; Gillespie, John W., Jr.] Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA.
RP Wetzel, ED (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM eric.d.wetzel2.civ@mail.mil
FU Army Research Laboratory
FX The authors would like to acknowledge Kyle Slusarski (ARL) for
assistance with optical microscopy. This research was sponsored by the
Army Research Laboratory and was accomplished under Cooperative
Agreement Number W911NF-06-2-0011. The views and conclusions contained
in this document are those of the authors and should not be interested
as representing the official policies, either expressed or implied, of
the Army Research Laboratory or the U.S. Government. The U.S. Government
is authorized to reproduce and distribute reprints for Government
purposes notwithstanding any copyright notation herein.
NR 23
TC 5
Z9 6
U1 3
U2 27
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1359-8368
EI 1879-1069
J9 COMPOS PART B-ENG
JI Compos. Pt. B-Eng.
PD JAN
PY 2015
VL 68
BP 215
EP 229
DI 10.1016/j.compositesb.2014.08.033
PG 15
WC Engineering, Multidisciplinary; Materials Science, Composites
SC Engineering; Materials Science
GA AT3GK
UT WOS:000344823700025
ER
PT J
AU Russell, K
Reinhardt, L
Lee, WT
AF Russell, Kevin
Reinhardt, Lyonel
Lee, Wen-Tzong
TI AN EVALUATION OF PRIMER PRESEATING IN SMALL CALIBER CARTRIDGE PRODUCTION
SO MECHANICS BASED DESIGN OF STRUCTURES AND MACHINES
LA English
DT Article
DE Cartridge case; Primer seating; Small caliber ammunition production;
Stamping process
AB This work presents the findings of a study to quantify the relative effectiveness of the primer preseating operation in small caliber cartridge production. In theory, primer preseating would enable cartridge stamping tools to achieve deeper stamping penetration depths and subsequently, greater primer retention forces. This is because, with preseating incorporated in the existing small caliber cartridge production process, a cartridge stamping tool would be fully dedicated to performing the case stamping operation (rather than the simultaneous primer seating and case stamping operations it currently performs). The findings presented in this work include measured percentages of total stamping tool force dedicated to primer seating, stamping tool penetration depths with and without primer preseating and primer retention forces with and without primer preseating. These findings and their underlying principles were produced through a static force equilibrium analysis and finite element modeling and simulation studies.
C1 [Russell, Kevin] New Jersey Inst Technol, Dept Mech & Ind Engn, Newark, NJ 07102 USA.
[Reinhardt, Lyonel] US Army Res, Armaments Engn & Technol Ctr, Ctr Dev & Engn, Picatinny Arsenal, NJ USA.
[Lee, Wen-Tzong] Natl Pingtung Univ Sci & Technol, Dept Biomechatron Engn, Neipu, Pingtung, Taiwan.
RP Russell, K (reprint author), New Jersey Inst Technol, Dept Mech & Ind Engn, Newark, NJ 07102 USA.
EM kevin.russell@njit.edu
NR 11
TC 0
Z9 0
U1 2
U2 4
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 CHESTNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1539-7734
EI 1539-7742
J9 MECH BASED DES STRUC
JI Mech. Based Des. Struct. Mech.
PY 2015
VL 43
IS 1
BP 112
EP 123
DI 10.1080/15397734.2014.908725
PG 12
WC Mechanics
SC Mechanics
GA AP8FN
UT WOS:000342314300007
ER
PT J
AU Jokanovic, B
Amin, M
Dogaru, T
AF Jokanovic, Branka
Amin, Moeness
Dogaru, Traian
TI Time-Frequency Signal Representations Using Interpolations in
Joint-Variable Domains
SO IEEE GEOSCIENCE AND REMOTE SENSING LETTERS
LA English
DT Article
DE Ambiguity domain; cross-terms reduction; interpolation; micro Doppler;
radar; time-frequency distribution (TFD)
ID TARGET DETECTION; DECOMPOSITION; DISTRIBUTIONS; KERNELS
AB Time-frequency (TF) representations are a powerful tool for analyzing Doppler and micro-Doppler signals. These signals are frequently encountered in various radar applications. Data interpolators play a unique role in TF signal representations under missing samples. When applied in the instantaneous autocorrelation domain over the time variable, the low-pass filter characteristic underlying linear interpolators lends itself to cross-terms reduction in the ambiguity domain. This is in contrast to interpolation performed over the lag variable or a direct interpolation of the raw data. We demonstrate the interpolator performance in both the time domain and the time-lag domain and compare it with sparse signal reconstruction, which exploits the local sparsity property assumed by most Doppler radar signals.
C1 [Jokanovic, Branka; Amin, Moeness] Villanova Univ, Ctr Adv Commun, Villanova, PA 19085 USA.
[Dogaru, Traian] US Army Res Lab, Adelphi, MD 20783 USA.
RP Jokanovic, B (reprint author), Villanova Univ, Ctr Adv Commun, Villanova, PA 19085 USA.
EM branka.jokanovic@villanova.edu
FU U.S. Army Research Office/Army Research Laboratory [W911NF-11-1-0536]
FX This work was supported by the U.S. Army Research Office/Army Research
Laboratory under Contract W911NF-11-1-0536.
NR 26
TC 2
Z9 2
U1 0
U2 11
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1545-598X
EI 1558-0571
J9 IEEE GEOSCI REMOTE S
JI IEEE Geosci. Remote Sens. Lett.
PD JAN
PY 2015
VL 12
IS 1
BP 204
EP 208
DI 10.1109/LGRS.2014.2332162
PG 5
WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote
Sensing; Imaging Science & Photographic Technology
SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science
& Photographic Technology
GA AN9TU
UT WOS:000340952500042
ER
PT J
AU Hartzell, PJ
Glennie, CL
Finnegan, DC
AF Hartzell, Preston J.
Glennie, Craig L.
Finnegan, David C.
TI Empirical Waveform Decomposition and Radiometric Calibration of a
Terrestrial Full-Waveform Laser Scanner
SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING
LA English
DT Article
DE Calibration; full waveform; Light Detection And Ranging (LiDAR);
reflectance; remote sensing
ID INTENSITY DATA; LIDAR DATA; CLASSIFICATION; DISCRIMINATION
AB The parametric models used in Light Detection And Ranging (LiDAR) waveform decomposition routines are inherently estimates of the sensor's system response to backscattered laser pulse power. This estimation can be improved with an empirical system response model, yielding reduced waveform decomposition residuals and more precise echo ranging. We develop an empirical system response model for a Riegl VZ-400 terrestrial laser scanner, from a series of observations to calibrated reflectance targets, and present a numerical least squaresmethod for decomposing waveforms with the model. The target observations are also used to create an empirical radiometric calibration model that accommodates a nonlinear relationship between received optical power and echo peak amplitude, and to examine the temporal stability of the instrument. We find that the least squares waveform decomposition based on the empirical system response model decreases decomposition fitting errors by an order of magnitude for high-amplitude returns and reduces range estimation errors on planar surfaces by 17% over a Gaussian model. The empirical radiometric calibration produces reflectance values self-consistent to within 5% for several materials observed at multiple ranges, and analysis of multiple calibration data sets collected over a one-year period indicates that echo peak amplitude values are stable to within +/- 3% for target ranges up to 125 m.
C1 [Hartzell, Preston J.; Glennie, Craig L.] Univ Houston, Dept Civil & Environm Engn, Houston, TX 77204 USA.
[Finnegan, David C.] US Army, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA.
RP Hartzell, PJ (reprint author), Univ Houston, Dept Civil & Environm Engn, Houston, TX 77204 USA.
EM pjhartzell@uh.edu; clglennie@uh.edu; david.finnegan@usace.army.mil
FU U.S. Department of Energy; CRREL
FX The work of P. J. Hartzell was supported through an appointment to the
Student Research Participation Program at the U.S. Army Cold Regions
Research and Engineering Laboratory (CRREL) administered by the Oak
Ridge Institute for Science and Education through an interagency
agreement between the U.S. Department of Energy and CRREL.
NR 30
TC 6
Z9 6
U1 5
U2 38
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0196-2892
EI 1558-0644
J9 IEEE T GEOSCI REMOTE
JI IEEE Trans. Geosci. Remote Sensing
PD JAN
PY 2015
VL 53
IS 1
BP 162
EP 172
DI 10.1109/TGRS.2014.2320134
PG 11
WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote
Sensing; Imaging Science & Photographic Technology
SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science
& Photographic Technology
GA AO7MG
UT WOS:000341536700013
ER
PT J
AU Ramirez, A
Arce, GR
Sadler, BM
AF Ramirez, Ana
Arce, Gonzalo R.
Sadler, Brian M.
TI Spectral Image Unmixing From Optimal Coded-Aperture Compressive
Measurements
SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING
LA English
DT Article
DE Coded aperture; coded-aperture snapshot spectral imaging system (CASSI);
hyperspectral imagery; sparsity; spectral unmixing
ID DESIGN
AB Hyperspectral remote sensing often captures imagery where the spectral profiles of the spatial pixels are the result of the reflectance contribution of numerous materials. Spectral unmixing is then used to extract the collection of materials, or endmembers, contained in the measured spectra and a set of corresponding fractions that indicate the abundance of each material present at each pixel. This paper aims at developing a spectral unmixing algorithm directly from compressive measurements acquired using the coded-aperture snapshot spectral imaging (CASSI) system. The proposed method first uses the compressive measurements to find a sparse vector representation of each pixel in a 3-D dictionary formed by a 2-D wavelet basis and a known spectral library of endmembers. The sparse vector representation is estimated by solving a sparsity-constrained optimization problem using an algorithm based on the variable splitting augmented Lagrangian multipliers method. The performance of the proposed spectral unmixing method is improved by taking optimal CASSI compressive measurements obtained when optimal coded apertures are used in the optical system. The optimal coded apertures are designed such that the CASSI sensing matrix satisfies a restricted isometry property with high probability. Simulations with synthetic and real hyperspectral cubes illustrate the accuracy of the proposed unmixing method.
C1 [Ramirez, Ana] Univ Ind Santander, Dept Elect Engn, Santander 680002, Colombia.
[Arce, Gonzalo R.] Univ Delaware, Dept Elect & Comp Engn, Newark, DE 19716 USA.
[Sadler, Brian M.] US Army Res Lab, Adelphi, MD 20783 USA.
RP Ramirez, A (reprint author), Univ Ind Santander, Dept Elect Engn, Santander 680002, Colombia.
FU Army Research Laboratory; Army Research Office [W911NF-11-1-0368];
National Science Foundation [CCF-0915800]
FX Manuscript received September 15, 2013; revised February 27, 2014;
accepted April 29, 2014. This work was supported in part by the Army
Research Laboratory and the Army Research Office under Grant
W911NF-11-1-0368 and in part by the National Science Foundation under
Grant CCF-0915800.
NR 27
TC 2
Z9 3
U1 2
U2 29
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0196-2892
EI 1558-0644
J9 IEEE T GEOSCI REMOTE
JI IEEE Trans. Geosci. Remote Sensing
PD JAN
PY 2015
VL 53
IS 1
BP 405
EP 415
DI 10.1109/TGRS.2014.2322820
PG 11
WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote
Sensing; Imaging Science & Photographic Technology
SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science
& Photographic Technology
GA AO7MG
UT WOS:000341536700031
ER
PT J
AU Satapathi, S
Gill, HS
Li, L
Samuelson, L
Kumar, J
Mosurkal, R
AF Satapathi, Soumitra
Gill, Hardeep Singh
Li, Lian
Samuelson, Lynne
Kumar, Jayant
Mosurkal, Ravi
TI Synthesis of nanoparticles of P3HT and PCBM for optimizing morphology in
polymeric solar cells
SO APPLIED SURFACE SCIENCE
LA English
DT Article
DE Conjugated polymer; Nanoparticles; Morphology; Polymeric solar cells
ID BAND-GAP POLYMERS; FORCE MICROSCOPY; PHOTOVOLTAICS; LAYERS
AB Nanoparticles (NPs) with opposite charges of a donor polymer, poly(3-hexyl thiophene) (P3HT) and an acceptor molecule, phenyl-C61-butyric acid methyl ester (PCBM) were synthesized using simple miniemulsion technique. The NPs were examined by dynamic light scattering, atomic force microscopy and scanning electron microscopy to confirm the formation of the NPs. The NPs were assembled into thin films by spin-coating of a blend of the NPs dispersion. The built-up of a five layered film was monitored by UV-vis absorption spectroscopy. Our preliminary study demonstrated that a solar cell made from an annealed NP film can exhibit photovoltaic response. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Satapathi, Soumitra; Gill, Hardeep Singh; Kumar, Jayant] Univ Massachusetts, Ctr Adv Mat, Lowell, MA 01854 USA.
[Satapathi, Soumitra; Gill, Hardeep Singh; Kumar, Jayant] Univ Massachusetts, Dept Phys & Appl Phys, Lowell, MA 01854 USA.
[Li, Lian; Samuelson, Lynne; Mosurkal, Ravi] US Army, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA.
RP Mosurkal, R (reprint author), US Army, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA.
EM Ravi.Mosurkal.civ@mail.mil
RI MOSURKAL, RAVI/P-6981-2015
FU U.S. Army Natick Soldier Research, Development and Engineering Center
(NSRDEC); Energy Frontiers Research Centers (EFRC) from U.S. Department
of Energy; Center for Advanced Materials at the University of
Massachusetts Lowell
FX Financial support from U.S. Army Natick Soldier Research, Development
and Engineering Center (NSRDEC) and the Energy Frontiers Research
Centers (EFRC) from U.S. Department of Energy is gratefully
acknowledged. S.S. will like to thank the 2012 Tripathy Summer Graduate
Fellowship from the Center for Advanced Materials at the University of
Massachusetts Lowell. This research was also supported in part by an
appointment to the Faculty Research Participation Program at the U.S.
Army NSRDEC administered by the Oak Ridge Institute for Science and
Education through an inter-agency agreement between the U.S. Department
of Energy and NSRDEC.
NR 22
TC 10
Z9 10
U1 1
U2 38
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0169-4332
EI 1873-5584
J9 APPL SURF SCI
JI Appl. Surf. Sci.
PD DEC 30
PY 2014
VL 323
BP 13
EP 18
DI 10.1016/j.apsusc.2014.07.175
PG 6
WC Chemistry, Physical; Materials Science, Coatings & Films; Physics,
Applied; Physics, Condensed Matter
SC Chemistry; Materials Science; Physics
GA AU3KJ
UT WOS:000345511600004
ER
PT J
AU Zaar, M
Fedyk, CG
Pidcoke, HF
Scherer, MR
Ryan, KL
Rickards, CA
Hinojosa-Laborde, C
Convertino, VA
Cap, AP
AF Zaar, Morten
Fedyk, Chriselda G.
Pidcoke, Heather F.
Scherer, Michael R.
Ryan, Kathy L.
Rickards, Caroline A.
Hinojosa-Laborde, Carmen
Convertino, Victor A.
Cap, Andrew P.
TI Platelet Activation after Presyncope by Lower Body Negative Pressure in
Humans
SO PLOS ONE
LA English
DT Article
ID COAGULATION SYSTEM; BLOOD; VASOPRESSIN; MECHANISMS; HEMORRHAGE;
TOLERANCE; RESPONSES; TRAUMA; STATE; MEN
AB Central hypovolemia elevates hemostatic activity which is essential for preventing exsanguination after trauma, but platelet activation to central hypovolemia has not been described. We hypothesized that central hypovolemia induced by lower body negative pressure (LBNP) activates platelets. Eight healthy subjects were exposed to progressive central hypovolemia by LBNP until presyncope. At baseline and 5 min after presyncope, hemostatic activity of venous blood was evaluated by flow cytometry, thrombelastography, and plasma markers of coagulation and fibrinolysis. Cell counts were also determined. Flow cytometry revealed that LBNP increased mean fluorescence intensity of PAC-1 by 1959 +/- 455 units (P< 0.001) and percent of fluorescence-positive platelets by 27 +/- 18%-points (P=0.013). Thrombelastography demonstrated that coagulation was accelerated (R-time decreased by 0.8 +/- 0.4 min (P=0.001)) and that clot lysis increased (LY60 by 6.0 +/- 5.8%-points (P=0.034)). Plasma coagulation factor VIII and von Willebrand factor ristocetin cofactor activity increased (P=0.011 and P=0.024, respectively), demonstrating increased coagulation activity, while von Willebrand factor antigen was unchanged. Plasma protein C activity and tissue-type plasminogen activator increased (P=0.007 and P=0.017, respectively), and D-dimer increased by 0.03 +/- 0.02 mg l(-1) (P=0.031), demonstrating increased fibrinolytic activity. Plasma prothrombin time and activated partial thromboplastin time were unchanged. Platelet count increased by 15 +/- 13% (P=0.014) and red blood cells by 9 +/- 4% (P=0.002). In humans, LBNP-induced presyncope activates platelets, as evidenced by increased exposure of active glycoprotein IIb/IIIa, accelerates coagulation. LBNP activates fibrinolysis, similar to hemorrhage, but does not alter coagulation screening tests, such as prothrombin time and activated partial thromboplastin time. LBNP results in increased platelet counts, but also in hemoconcentration.
C1 [Zaar, Morten] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.
[Fedyk, Chriselda G.; Pidcoke, Heather F.; Scherer, Michael R.; Ryan, Kathy L.; Hinojosa-Laborde, Carmen; Convertino, Victor A.; Cap, Andrew P.] US Army Inst Surg Res, Ft Sam Houston, TX USA.
[Rickards, Caroline A.] Univ N Texas, Hlth Sci Ctr Ft Worth, Ft Worth, TX USA.
RP Zaar, M (reprint author), Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.
EM zaar@uthscsa.edu
FU United States Army, Medical Research and Materiel Command
FX This study was funded by the United States Army, Medical Research and
Materiel Command. The funders had no role in study design, data
collection and analysis, decision to publish, or preparation of the
manuscript.
NR 31
TC 1
Z9 1
U1 1
U2 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD DEC 29
PY 2014
VL 9
IS 12
DI 10.1371/journal.pone.0116174
PG 12
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AX7UN
UT WOS:000347120200104
ER
PT J
AU Schreiber, JM
Omcikus, ZR
Eden, TJ
Sharma, MM
Champagne, V
Patankar, SN
AF Schreiber, J. M.
Omcikus, Z. R.
Eden, T. J.
Sharma, M. M.
Champagne, V.
Patankar, S. N.
TI Combined effect of hot extrusion and heat treatment on the mechanical
behavior of 7055 AA processed via spray metal forming
SO JOURNAL OF ALLOYS AND COMPOUNDS
LA English
DT Article
DE Extrusion aluminum alloys
ID ALUMINUM-ALLOY; TENSILE PROPERTIES; MICROSTRUCTURE
AB The mechanical properties of 7xxx series alloys can be tailored by subjecting them to deformation processing and heat treatment. In the present study dealing with spray forming of 7055 AA, extrusion and heat treatment involving solutionizing followed by peak aging resulted in improved mechanical behavior. The strength and ductility obtained are comparable to that of extruded and heat treated as-cast 7055 AA (Mondal et al., 2011) [1]. Spray forming offers an alternate route to develop high strength aluminum alloys and the current study is an attempt that draws closer to the target value of 1GPa strength and 10% ductility for high strength aluminum alloys. Published by Elsevier B.V.
C1 [Schreiber, J. M.; Omcikus, Z. R.; Eden, T. J.; Patankar, S. N.] Penn State Univ, Appl Res Lab, State Coll, PA 16801 USA.
[Sharma, M. M.] Bucknell Univ, Dept Mech Engn, Lewisburg, PA 17837 USA.
[Champagne, V.] US Army, Res Lab, Washington, DC USA.
RP Patankar, SN (reprint author), Penn State Univ, Appl Res Lab, State Coll, PA 16801 USA.
EM snp11@psu.edu
NR 13
TC 3
Z9 4
U1 8
U2 36
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0925-8388
EI 1873-4669
J9 J ALLOY COMPD
JI J. Alloy. Compd.
PD DEC 25
PY 2014
VL 617
BP 135
EP 139
DI 10.1016/j.jallcom.2014.07.184
PG 5
WC Chemistry, Physical; Materials Science, Multidisciplinary; Metallurgy &
Metallurgical Engineering
SC Chemistry; Materials Science; Metallurgy & Metallurgical Engineering
GA AS2UX
UT WOS:000344135800024
ER
PT J
AU Challacombe, JF
Stubben, CJ
Klimko, CP
Welkos, SL
Kern, SJ
Bozue, JA
Worsham, PL
Cote, CK
Wolfe, DN
AF Challacombe, Jean F.
Stubben, Chris J.
Klimko, Christopher P.
Welkos, Susan L.
Kern, Steven J.
Bozue, Joel A.
Worsham, Patricia L.
Cote, Christopher K.
Wolfe, Daniel N.
TI Interrogation of the Burkholderia pseudomallei Genome to Address
Differential Virulence among Isolates
SO PLOS ONE
LA English
DT Article
ID BACILLUS-SUBTILIS; ANTIBIOTIC SUSCEPTIBILITY; NORTHERN AUSTRALIA; CARBON
METABOLISM; ACUTE MELIOIDOSIS; CAUSATIVE AGENT; GENE-EXPRESSION;
BACTERIA; RPOS; ADAPTATION
AB Infection by the Gram-negative pathogen Burkholderia pseudomallei results in the disease melioidosis, acquired from the environment in parts of southeast Asia and northern Australia. Clinical symptoms of melioidosis range from acute (fever, pneumonia, septicemia, and localized infection) to chronic (abscesses in various organs and tissues, most commonly occurring in the lungs, liver, spleen, kidney, prostate and skeletal muscle), and persistent infections in humans are difficult to cure. Understanding the basic biology and genomics of B. pseudomallei is imperative for the development of new vaccines and therapeutic interventions. This formidable task is becoming more tractable due to the increasing number of B. pseudomallei genomes that are being sequenced and compared.
Here, we compared three B. pseudomallei genomes, from strains MSHR668, K96243 and 1106a, to identify features that might explain why MSHR668 is more virulent than K96243 and 1106a in a mouse model of B. pseudomallei infection. Our analyses focused on metabolic, virulence and regulatory genes that were present in MSHR668 but absent from both K96243 and 1106a. We also noted features present in K96243 and 1106a but absent from MSHR668, and identified genomic differences that may contribute to variations in virulence noted among the three B. pseudomallei isolates. While this work contributes to our understanding of B. pseudomallei genomics, more detailed experiments are necessary to characterize the relevance of specific genomic features to B. pseudomallei metabolism and virulence. Functional analyses of metabolic networks, virulence and regulation shows promise for examining the effects of B. pseudomallei on host cell metabolism and will lay a foundation for future prediction of the virulence of emerging strains. Continued emphasis in this area will be critical for protection against melioidosis, as a better understanding of what constitutes a fully virulent Burkholderia isolate may provide for better diagnostic and medical countermeasure strategies.
C1 [Challacombe, Jean F.; Stubben, Chris J.] Los Alamos Natl Lab, Biosci Div, Los Alamos, NM 87545 USA.
[Klimko, Christopher P.; Welkos, Susan L.; Bozue, Joel A.; Worsham, Patricia L.; Cote, Christopher K.] US Army Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD USA.
[Kern, Steven J.] US Army Med Res Inst Infect Dis, Div Biostat, Ft Detrick, MD USA.
[Wolfe, Daniel N.] Def Threat Reduct Agcy, Chem & Biol Technol Dept, Ft Belvoir, VA USA.
RP Challacombe, JF (reprint author), Los Alamos Natl Lab, Biosci Div, Los Alamos, NM 87545 USA.
EM jchalla@lanl.gov
FU Defense Threat Reduction Agency (CCAR) [CB3846 PPE-1,
CBS119924543-7049-BASIC]
FX This project was funded by the Defense Threat Reduction Agency (CCAR#
CB3846 PPE-1 Burkholderia and CBS119924543-7049-BASIC). The funder had
no role in study design, data collection and analysis, or decision to
publish the manuscript. DNW contributed to the writing of the
manuscript.
NR 73
TC 5
Z9 5
U1 0
U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD DEC 23
PY 2014
VL 9
IS 12
AR e115951
DI 10.1371/journal.pone.0115951
PG 27
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AZ9UY
UT WOS:000348563300091
PM 25536074
ER
PT J
AU Coulibaly, S
Heinzmann, C
Beyer, FL
Balog, S
Weder, C
Fiore, GL
AF Coulibaly, Souleymane
Heinzmann, Christian
Beyer, Frederick L.
Balog, Sandor
Weder, Christoph
Fiore, Gina L.
TI Supramolecular Polymers with Orthogonal Functionality
SO MACROMOLECULES
LA English
DT Article
ID THERMOPLASTIC ELASTOMERS; TRIBLOCK COPOLYMERS; COMPLEXES; CHAIN
AB Supramolecular polymers with orthogonal interactions are of broad interest, and reports on such materials with multifunctional stimuli-responsive behavior are rare. Polymer blends based on a poly(ethylene-co-butylene) core (PEB) terminated with either 2-ureido-4[1H]-pyrimidinone (UPy) hydrogen-bonding motifs (UPy-PEB-UPy) or 2,6-bis(1'-methylbenzimidazolyl)pyridine (Mebip) ligands coordinated to metal ions ([M(Mebip-PEB-Mebip)](2+) (M = Zn, Fe)) were prepared. The degree of orthogonality of the supramolecular polymer blends was explored by UVvis spectroscopy, small-angle X-ray scattering, and dynamic mechanical thermal analysis (DMTA). Polymer blends of [Zn(Mebip-PEB-Mebip)](NTf2)(2) and UPy-PEB-UPy resulted in a statistical mixture of noncovalent interactions, whereas blends with [Fe(Mebip-PEB-Mebip)](ClO4)(2) and UPy-PEB-UPy assembled in an orthogonal fashion. Additionally, the DMTA showed two transitions for the disassembly of UPy (ca. 60 degrees C) and Fe2+-Mebip (ca. 180 degrees C) phases. The Fe2+-Mebip interactions were selectively disrupted by the addition of a competitive ligand, demonstrating that each supramolecular motif can be targeted with either a thermal or chemical stimulus.
C1 [Coulibaly, Souleymane; Heinzmann, Christian; Balog, Sandor; Weder, Christoph; Fiore, Gina L.] Univ Fribourg, Adolphe Merkle Inst, CH-1700 Fribourg, Switzerland.
[Beyer, Frederick L.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Weder, C (reprint author), Univ Fribourg, Adolphe Merkle Inst, Chemin Verdiers 4, CH-1700 Fribourg, Switzerland.
EM christoph.weder@unifr.ch; gina.fiore@unifr.ch
RI Balog, Sandor/F-3860-2014;
OI Balog, Sandor/0000-0002-4847-9845; Merkle Institute,
Adolphe/0000-0002-6220-424X
FU Swiss National Science Foundation [200021_13540/1, R'equip
206021_128728]; US Army Research Office [W911NF-12-1-0339]; Swiss
Commission for Technology and Innovation (CTI) [13746.1]; Adolphe Merkle
Foundation
FX We acknowledge funding from the Swiss National Science Foundation
(200021_13540/1 and R'equip 206021_128728), the US Army Research Office
(W911NF-12-1-0339), the Swiss Commission for Technology and Innovation
(CTI, Grant No 13746.1), and the Adolphe Merkle Foundation.
NR 33
TC 5
Z9 5
U1 5
U2 66
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0024-9297
EI 1520-5835
J9 MACROMOLECULES
JI Macromolecules
PD DEC 23
PY 2014
VL 47
IS 24
BP 8487
EP 8496
DI 10.1021/ma501492u
PG 10
WC Polymer Science
SC Polymer Science
GA AX8CO
UT WOS:000347138300002
ER
PT J
AU McConnell, ER
Bell, SM
Cote, I
Wang, RL
Perkins, EJ
Garcia-Reyero, N
Gong, P
Burgoon, LD
AF McConnell, Emma R.
Bell, Shannon M.
Cote, Ila
Wang, Rong-Lin
Perkins, Edward J.
Garcia-Reyero, Natalia
Gong, Ping
Burgoon, Lyle D.
TI Systematic Omics Analysis Review (SOAR) Tool to Support Risk Assessment
SO PLOS ONE
LA English
DT Review
ID GENE-EXPRESSION; CIGARETTE-SMOKE; DIESEL EXHAUST; TRANSCRIPTOME; TCDD;
MICROARRAY; EXPOSURE; CELLS
AB Environmental health risk assessors are challenged to understand and incorporate new data streams as the field of toxicology continues to adopt new molecular and systems biology technologies. Systematic screening reviews can help risk assessors and assessment teams determine which studies to consider for inclusion in a human health assessment. A tool for systematic reviews should be standardized and transparent in order to consistently determine which studies meet minimum quality criteria prior to performing in-depth analyses of the data. The Systematic Omics Analysis Review (SOAR) tool is focused on assisting risk assessment support teams in performing systematic reviews of transcriptomic studies. SOAR is a spreadsheet tool of 35 objective questions developed by domain experts, focused on transcriptomic microarray studies, and including four main topics: test system, test substance, experimental design, and microarray data. The tool will be used as a guide to identify studies that meet basic published quality criteria, such as those defined by the Minimum Information About a Microarray Experiment standard and the Toxicological Data Reliability Assessment Tool. Seven scientists were recruited to test the tool by using it to independently rate 15 published manuscripts that study chemical exposures with microarrays. Using their feedback, questions were weighted based on importance of the information and a suitability cutoff was set for each of the four topic sections. The final validation resulted in 100% agreement between the users on four separate manuscripts, showing that the SOAR tool may be used to facilitate the standardized and transparent screening of microarray literature for environmental human health risk assessment.
C1 [McConnell, Emma R.; Bell, Shannon M.] Oak Ridge Inst Sci & Educ, Res Triangle Pk, NC USA.
[Cote, Ila] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Arlington, VA USA.
[Wang, Rong-Lin] US EPA, Natl Exposure Res Lab, Off Res & Dev, Cincinnati, OH USA.
[Perkins, Edward J.] US Army, Corps Engineers, Dept Army, Dept Def, Vicksburg, MS 39180 USA.
[Garcia-Reyero, Natalia] Jackson State Univ, Dept Chem & Biochem, Jackson, MS USA.
[Gong, Ping] SpecPro Inc, Vicksburg, MS USA.
[Burgoon, Lyle D.] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Burgoon, LD (reprint author), US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
EM Burgoon.Lyle@epa.gov
OI Burgoon, Lyle/0000-0003-4977-5352
FU US EPA's Human Health Risk Assessment Program; SpecPro, Inc
FX This work was funded by the US EPA's Human Health Risk Assessment
Program. The funders had no role in study design, or data collection and
analysis. EPA management cleared the manuscript for publication, which
included helpful suggestions that improved the overall quality of the
manuscript, consistent with the US EPA Scientific Integrity Policy.
Co-author Ping Gong is employed by SpecPro, Inc. SpecPro, Inc provided
support in the form of salary for author PG, but did not have any
additional role in the study design, data collection and analysis,
decision to publish, or preparation of the manuscript. The specific role
of this author is articulated in the 'author contributions' section.
NR 29
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U1 1
U2 13
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD DEC 22
PY 2014
VL 9
IS 12
AR UNSP e110379
DI 10.1371/journal.pone.0110379
PG 14
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CA3ZY
UT WOS:000348845100002
PM 25531884
ER
PT J
AU Farquharson, S
Shende, C
Smith, W
Huang, H
Inscore, F
Sengupta, A
Sperry, J
Sickler, T
Prugh, A
Guicheteau, J
AF Farquharson, Stuart
Shende, Chetan
Smith, Wayne
Huang, Hermes
Inscore, Frank
Sengupta, Atanu
Sperry, Jay
Sickler, Todd
Prugh, Amber
Guicheteau, Jason
TI Selective detection of 1000 B. anthracis spores within 15 minutes using
a peptide functionalized SERS assay
SO ANALYST
LA English
DT Article
ID SURFACE-ENHANCED RAMAN; BACILLUS-ANTHRACIS; DIPICOLINIC ACID;
SPECTROSCOPY; SUBTILIS; ADSORPTION; EXTRACTION; PROTEINS; CEREUS; PCR
AB A surface-enhanced Raman spectroscopy (SERS) assay has been designed to detect Bacillus anthracis spores. The assay consists of silver nanoparticles embedded in a porous glass structure that have been functionalized with ATYPLPIR, a peptide developed to discriminately bind B. anthracis versus other species of Bacillus. Once bound, acetic acid was used to release the biomarker dipicolinic acid from the spores, which was detected by SERS through the addition of silver colloids. This SERS assay was used to selectively bind B. anthracis with a 100-fold selectivity versus B. cereus, and to detect B. anthracis Ames at concentrations of 1000 spores per mL within 15 minutes. The SERS assay measurements provide a basis for the development of systems that can detect spores collected from the air or from water supplies.
C1 [Farquharson, Stuart; Shende, Chetan; Smith, Wayne; Inscore, Frank] Real Time Analyzers Inc, Middletown, CT 06457 USA.
[Huang, Hermes] Smiths Detect, Danbury, CT 06810 USA.
[Sengupta, Atanu] Dr Reddys Labs, Bachupally 500090, Andhra Pradesh, India.
[Sperry, Jay] Univ Rhode Isl, Dept Cell & Mol Biol, Kingston, RI 02881 USA.
[Sickler, Todd; Prugh, Amber; Guicheteau, Jason] US Army Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA.
RP Farquharson, S (reprint author), Real Time Analyzers Inc, 362 Ind Pk Rd,Unit 8, Middletown, CT 06457 USA.
EM stu@rta.biz
FU Defense Advanced Research Projects Agency [N10PC2077, D11PC20171];
National Science Foundation [DMI-0349687, IIP-0810335, II-0956170]
FX The authors are grateful for funding from the Defense Advanced Research
Projects Agency (N10PC2077 and D11PC20171) and the National Science
Foundation (DMI-0349687, IIP-0810335, and II-0956170).
NR 42
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U1 6
U2 52
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 0003-2654
EI 1364-5528
J9 ANALYST
JI Analyst
PD DEC 21
PY 2014
VL 139
IS 24
BP 6366
EP 6370
DI 10.1039/c4an01163e
PG 5
WC Chemistry, Analytical
SC Chemistry
GA AT9SB
UT WOS:000345265300007
PM 25263740
ER
PT J
AU Yuffa, AJ
Gurton, KP
Videen, G
AF Yuffa, Alex J.
Gurton, Kristan P.
Videen, Gorden
TI Three-dimensional facial recognition using passive long-wavelength
infrared polarimetric imaging
SO APPLIED OPTICS
LA English
DT Article
ID HUMAN SKIN; OPTICAL-PROPERTIES; IN-VIVO; SURFACE; POLARIZATION; SHAPE;
RADIATION; TISSUES; RANGE; FIELD
AB We use a polarimetric camera to record the Stokes parameters and the degree of linear polarization of long-wavelength infrared radiation emitted by human faces. These Stokes images are combined with Fresnel relations to extract the surface normal at each pixel. Integrating over these surface normals yields a three-dimensional facial image. One major difficulty of this technique is that the normal vectors determined from the polarizations are not unique. We overcome this problem by introducing an additional boundary condition on the subject. The major sources of error in producing inversions are noise in the images caused by scattering of the background signal and the ambiguity in determining the surface normals from the Fresnel coefficients. (C) 2014 Optical Society of America
C1 [Yuffa, Alex J.; Gurton, Kristan P.; Videen, Gorden] US Army Res Lab, Computat & Informat Sci Directorate, Adelphi, MD 20783 USA.
RP Yuffa, AJ (reprint author), US Army Res Lab, Computat & Informat Sci Directorate, Adelphi, MD 20783 USA.
EM ayuffa@gmail.com
RI Yuffa, Alex/B-5498-2014
OI Yuffa, Alex/0000-0002-3600-1131
FU U.S. Army Research Laboratory Postdoctoral Fellowship Program
FX This research was supported in part by an appointment to the U.S. Army
Research Laboratory Postdoctoral Fellowship Program administered by the
Oak Ridge Associated Universities through a cooperative agreement with
the U.S. Army Research Laboratory.
NR 32
TC 5
Z9 5
U1 1
U2 9
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 1559-128X
EI 2155-3165
J9 APPL OPTICS
JI Appl. Optics
PD DEC 20
PY 2014
VL 53
IS 36
BP 8514
EP 8521
DI 10.1364/AO.53.008514
PG 8
WC Optics
SC Optics
GA AX3ED
UT WOS:000346822300018
PM 25608201
ER
PT J
AU Wiehe, K
Easterhoff, D
Luo, K
Nicely, NI
Bradley, T
Jaeger, FH
Dennison, SM
Zhang, RJ
Lloyd, KE
Stolarchuk, C
Parks, R
Sutherland, LL
Scearce, RM
Morris, L
Kaewkungwal, J
Nitayaphan, S
Pitisuttithum, P
Rerks-Ngarm, S
Sinangil, F
Phogat, S
Michael, NL
Kim, JH
Kelsoe, G
Montefiori, DC
Tomaras, GD
Bonsignori, M
Santra, S
Kepler, TB
Alam, SM
Moody, MA
Liao, HX
Haynes, BF
AF Wiehe, Kevin
Easterhoff, David
Luo, Kan
Nicely, Nathan I.
Bradley, Todd
Jaeger, Frederick H.
Dennison, S. Moses
Zhang, Ruijun
Lloyd, Krissey E.
Stolarchuk, Christina
Parks, Robert
Sutherland, Laura L.
Scearce, Richard M.
Morris, Lynn
Kaewkungwal, Jaranit
Nitayaphan, Sorachai
Pitisuttithum, Punnee
Rerks-Ngarm, Supachai
Sinangil, Faruk
Phogat, Sanjay
Michael, Nelson L.
Kim, Jerome H.
Kelsoe, Garnett
Montefiori, David C.
Tomaras, Georgia D.
Bonsignori, Mattia
Santra, Sampa
Kepler, Thomas B.
Alam, S. Munir
Moody, M. Anthony
Liao, Hua-Xin
Haynes, Barton F.
TI Antibody Light-Chain-Restricted Recognition of the Site of Immune
Pressure in the RV144 HIV-1 Vaccine Trial Is Phylogenetically Conserved
SO IMMUNITY
LA English
DT Article
ID IMMUNODEFICIENCY-VIRUS TYPE-1; PROXIMAL EXTERNAL REGION; NEUTRALIZING
ANTIBODIES; MONOCLONAL-ANTIBODIES; EFFICACY TRIAL; GP41; REACTIVITY;
AFFINITY; BINDING; IDENTIFICATION
AB In HIV-1, the ability to mount antibody responses to conserved, neutralizing epitopes is critical for protection. Here we have studied the light chain usage of human and rhesus macaque antibodies targeted to a dominant region of the HIV-1 envelope second variable (V2) region involving lysine (K) 169, the site of immune pressure in the RV144 vaccine efficacy trial. We found that humans and rhesus macaques used orthologous lambda variable gene segments encoding a glutamic acid-aspartic acid (ED) motif for K169 recognition. Structure determination of an unmutated ancestor antibody demonstrated that the V2 binding site was preconfigured for ED motifmediated recognition prior to maturation. Thus, light chain usage for recognition of the site of immune pressure in the RV144 trial is highly conserved across species. These data indicate that the HIV-1 K169-recognizing ED motif has persisted over the diversification between rhesus macaques and humans, suggesting an evolutionary advantage of this antibody recognition mode.
C1 [Wiehe, Kevin; Easterhoff, David; Luo, Kan; Nicely, Nathan I.; Bradley, Todd; Jaeger, Frederick H.; Dennison, S. Moses; Zhang, Ruijun; Lloyd, Krissey E.; Stolarchuk, Christina; Parks, Robert; Sutherland, Laura L.; Scearce, Richard M.; Kelsoe, Garnett; Montefiori, David C.; Tomaras, Georgia D.; Bonsignori, Mattia; Alam, S. Munir; Moody, M. Anthony; Liao, Hua-Xin; Haynes, Barton F.] Duke Univ, Sch Med, Duke Human Vaccine Inst, Durham, NC 27710 USA.
[Morris, Lynn] Natl Inst Communicable Dis, ZA-2131 Johannesburg, South Africa.
[Morris, Lynn] Ctr AIDS Programme Res South Africa CAPRISA, Durban, South Africa.
[Kaewkungwal, Jaranit; Pitisuttithum, Punnee] Mahidol Univ, Dept Trop Med, Bangkok 10400, Thailand.
[Nitayaphan, Sorachai] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
[Rerks-Ngarm, Supachai] Minist Publ Hlth, Dept Dis Control, Nonthaburi 11000, Thailand.
[Sinangil, Faruk] Sanofi Pasteur Inc, Swiftwater, PA 18370 USA.
[Phogat, Sanjay] Global Solut Infect Dis, San Francisco, CA 94080 USA.
[Michael, Nelson L.; Kim, Jerome H.] Walter Reed Army Inst Res, US Mil Res Program, Silver Spring, MD 20910 USA.
[Santra, Sampa] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Boston, MA 02215 USA.
[Kepler, Thomas B.] Boston Univ, Dept Microbiol, Boston, MA 02118 USA.
RP Wiehe, K (reprint author), Duke Univ, Sch Med, Duke Human Vaccine Inst, Durham, NC 27710 USA.
EM kevin.wiehe@dm.duke.edu; barton.haynes@dm.duke.edu
RI Tomaras, Georgia/J-5041-2016
FU Collaboration for AIDS Vaccine Discovery from the Bill & Melinda Gates
Foundation [OPP1033098]; Center for HIV/AIDS Vaccine
Immunology-Immuongen Discovery (CHAVI-ID) from NIH/NIAID/DAIDS
[UMI-AI100645]; Duke University Center for AIDS Research Flow Cytometry
core (NIAID, NIH) [P30-AI-64518]; U.S. Army Medical Research and
Material Command (USAMRMC) [Y1-AI-2642-12]; Henry M. Jackson Foundation
for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; U.S.
Department of Defense (DOD) [W81XWH-07-2-0067]; U.S. Department of
Energy, Office of Science, Office of Basic Energy Sciences
[W-31-109-Eng-38]; NIAID (NIH) [5T32-AI007392]
FX This work was supported by Collaboration for AIDS Vaccine Discovery
grants from the Bill & Melinda Gates Foundation (grant ID OPP1033098)
and by the Center for HIV/AIDS Vaccine Immunology-Immuongen Discovery
(CHAVI-ID; UMI-AI100645) grant from NIH/NIAID/DAIDS. This work was also
supported by grant number 5T32-AI007392 from the NIAID (NIH). Flow
cytometry work was additionally supported by The Duke University Center
for AIDS Research Flow Cytometry core (NIAID, NIH, CFAR grant
P30-AI-64518). Funding was also provided by Interagency Agreement
Y1-AI-2642-12 between U.S. Army Medical Research and Material Command
(USAMRMC) and the (W81XWH-07-2-0067) between the Henry M. Jackson
Foundation for the Advancement of Military Medicine, Inc., and the U.S.
Department of Defense (DOD). The views expressed in this article are
those of the authors and should not be construed as official or as
representing the views of the Department of Defense or the Department of
the Army. Use of the Advanced Photon Source was supported by the U.S.
Department of Energy, Office of Science, Office of Basic Energy
Sciences, under Contract No. W-31-109-Eng-38. We thank A. Foulger for
expert technical assistance in antibody production; D. Marshall and J.
Whitesides for expert technical assistance in flow cytometry; A.
Martelli for expert technical assistance in neutralization assays; and
K. Soderberg and S. Bowen for project management.
NR 43
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Z9 20
U1 1
U2 4
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 1074-7613
EI 1097-4180
J9 IMMUNITY
JI Immunity
PD DEC 18
PY 2014
VL 41
IS 6
BP 909
EP 918
DI 10.1016/j.immuni.2014.11.014
PG 10
WC Immunology
SC Immunology
GA AX0PM
UT WOS:000346654100010
PM 25526306
ER
PT J
AU Fasinu, PS
Tekwani, BL
Nanayakkara, NPD
Avula, B
Herath, HMTB
Wang, YH
Adelli, VR
Elsohly, MA
Khan, SI
Khan, IA
Pybus, BS
Marcsisin, SR
Reichard, GA
McChesney, JD
Walker, LA
AF Fasinu, Pius S.
Tekwani, Babu L.
Nanayakkara, N. P. Dhammika
Avula, Bharathi
Herath, H. M. T. Bandara
Wang, Yan-Hong
Adelli, Vijender R.
Elsohly, Mahmoud A.
Khan, Shabana I.
Khan, Ikhlas A.
Pybus, Brandon S.
Marcsisin, Sean R.
Reichard, Gregory A.
McChesney, James D.
Walker, Larry A.
TI Enantioselective metabolism of primaquine by human CYP2D6
SO MALARIA JOURNAL
LA English
DT Article
DE Primaquine enantiomers; CYP2D6; Metabolism; Ring-hydroxylation;
Quinone-imines; Orthoquinone
ID INDUCED HEMOLYTIC-ANEMIA; ANTIMALARIAL-DRUG PRIMAQUINE;
HUMAN-ERYTHROCYTES; RAT ERYTHROCYTES; VIVAX MALARIA;
5-HYDROXYPRIMAQUINE; 8-AMINOQUINOLINES; PHARMACOKINETICS;
IDENTIFICATION; HEMOTOXICITY
AB Background: Primaquine, currently the only approved drug for the treatment and radical cure of Plasmodium vivax malaria, is still used as a racemic mixture. Clinical use of primaquine has been limited due to haemolytic toxicity in individuals with genetic deficiency in glucose-6-phosphate dehydrogenase. Earlier studies have linked its therapeutic effects to CYP2D6-generated metabolites. The aim of the current study was to investigate the differential generation of the CYP2D6 metabolites by racemic primaquine and its individual enantiomers.
Methods: Stable isotope C-13-labelled primaquine and its two enantiomers were incubated with recombinant cytochrome-P450 supersomes containing CYP2D6 under optimized conditions. Metabolite identification and time-point quantitative analysis were performed using LC-MS/MS. UHPLC retention time, twin peaks with a mass difference of 6, MS-MS fragmentation pattern, and relative peak area with respect to parent compound were used for phenotyping and quantitative analysis of metabolites.
Results: The rate of metabolism of (+)-(S)-primaquine was significantly higher (50% depletion of 20 mu M in 120 min) compared to (-)-(R)-primaquine (30% depletion) when incubated with CYP2D6. The estimated V-max (mu mol/min/mg) were 0.75, 0.98 and 0.42, with K-m (mu M) of 24.2, 33.1 and 21.6 for (+/-)-primaquine, (+)-primaquine and (-)-primaquine, respectively. Three stable mono-hydroxylated metabolites, namely, 2-, 3-and 4-hydroxyprimaquine (2-OH-PQ, 3-OH-PQ, and 4-OH-PQ), were identified and quantified. 2-OH-PQ was preferentially formed from (+)-primaquine in a ratio of 4: 1 compared to (-)-primaquine. The racemic (+/-)-primaquine showed a pattern similar to the (-)-primaquine; 2-OH-PQ accounted for about 15-17% of total CYP2D6-mediated conversion of (+)-primaquine. In contrast, 4-OH-PQ was preferentially formed with (-)-primaquine (5: 1), accounting for 22% of the total (-)-primaquine conversion. 3-OH-PQ was generated from both enantiomers and racemate. 5-hydroxyprimaquine was unstable. Its orthoquinone degradation product (twice as abundant in (+)-primaquine compared to (-)-primaquine) was identified and accounted for 18-20% of the CYP2D6-mediated conversion of (+)-primaquine. Other minor metabolites included dihydroxyprimaquine species, two quinone-imine products of dihydroxylated primaquine, and a primaquine terminal alcohol with variable generation from the individual enantiomers.
Conclusion: The metabolism of primaquine by human CYP2D6 and the generation of its metabolites display enantio-selectivity regarding formation of hydroxylated product profiles. This may partly explain differential pharmacologic and toxicologic properties of primaquine enantiomers.
C1 [Fasinu, Pius S.; Tekwani, Babu L.; Nanayakkara, N. P. Dhammika; Avula, Bharathi; Herath, H. M. T. Bandara; Wang, Yan-Hong; Adelli, Vijender R.; Elsohly, Mahmoud A.; Khan, Shabana I.; Khan, Ikhlas A.; Walker, Larry A.] Univ Mississippi, Natl Ctr Nat Prod Res, University, MS 38677 USA.
[Tekwani, Babu L.; Khan, Shabana I.; Khan, Ikhlas A.; Walker, Larry A.] Univ Mississippi, BioMol Sci, University, MS 38677 USA.
[Elsohly, Mahmoud A.] Univ Mississippi, Sch Pharm, University, MS 38677 USA.
[Elsohly, Mahmoud A.] ElSohly Labs Inc, Oxford, MS 38655 USA.
[Pybus, Brandon S.; Marcsisin, Sean R.; Reichard, Gregory A.] Walter Reed Army Inst Res, Div Expt Therapeut, Mil Malaria Res Program, Silver Spring, MD 20910 USA.
[McChesney, James D.] Ironstone Separat Inc, Etta, MS 38627 USA.
RP Walker, LA (reprint author), Univ Mississippi, Natl Ctr Nat Prod Res, University, MS 38677 USA.
EM lwalker@olemiss.edu
FU Bill and Melinda Gates Foundation Phase I GCE Award [OPP53288]; US Army
Medical Research and Materiel Command Awards [W81XWH-07-2-0095,
W81XWH-10-2-0059]
FX This study is supported by Bill and Melinda Gates Foundation Phase I GCE
Award OPP53288 and the US Army Medical Research and Materiel Command
Awards Nos. W81XWH-07-2-0095 and W81XWH-10-2-0059 to the University of
Mississippi. The authors thank Dr David Jollow, Medical University of
South Carolina, retired, for his continuing input and advice and help in
interpretation.
NR 37
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U1 1
U2 9
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2875
J9 MALARIA J
JI Malar. J.
PD DEC 17
PY 2014
VL 13
AR 507
DI 10.1186/1475-2875-13-507
PG 12
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA AY4UW
UT WOS:000347574300001
PM 25518709
ER
PT J
AU Deng, YP
Ai, JM
Guan, X
Wang, ZH
Yan, B
Zhang, DQ
Liu, C
Wilbanks, MS
Escalon, BL
Meyers, SA
Yang, MQ
Perkins, EJ
AF Deng, Youping
Ai, Junmei
Guan, Xin
Wang, Zhaohui
Yan, Bin
Zhang, Daqin
Liu, Chang
Wilbanks, Mitch S.
Escalon, Barbara Lynn
Meyers, Sharon A.
Yang, Mary Qu
Perkins, Edward J.
TI MicroRNA and messenger RNA profiling reveals new biomarkers and
mechanisms for RDX induced neurotoxicity
SO BMC GENOMICS
LA English
DT Article
ID BOBWHITE COLINUS-VIRGINIANUS; AXON GUIDANCE; EXPOSURE; EXPRESSION;
TARGETS; LIVER; 1,3,5-TRINITRO-1,3,5-TRIAZINE; NEURODEGENERATION;
PHOSPHORYLATION; REPRESSION
AB Background: RDX is a well-known pollutant to induce neurotoxicity. MicroRNAs (miRNA) and messenger RNA (mRNA) profiles are useful tools for toxicogenomics studies. It is worthy to integrate MiRNA and mRNA expression data to understand RDX-induced neurotoxicity.
Results: Rats were treated with or without RDX for 48 h. Both miRNA and mRNA profiles were conducted using brain tissues. Nine miRNAs were significantly regulated by RDX. Of these, 6 and 3 miRNAs were up-and down-regulated respectively. The putative target genes of RDX-regulated miRNAs were highly nervous system function genes and pathways enriched. Fifteen differentially genes altered by RDX from mRNA profiles were the putative targets of regulated miRNAs. The induction of miR-71, miR-27ab, miR-98, and miR-135a expression by RDX, could reduce the expression of the genes POLE4, C5ORF13, SULF1 and ROCK2, and eventually induce neurotoxicity. Overexpression of miR-27ab, or reduction of the expression of unknown miRNAs by RDX, could up-regulate HMGCR expression and contribute to neurotoxicity. RDX regulated immune and inflammation response miRNAs and genes could contribute to RDX-induced neurotoxicity and other toxicities as well as animal defending reaction response to RDX exposure.
Conclusions: Our results demonstrate that integrating miRNA and mRNA profiles is valuable to indentify novel biomarkers and molecular mechanisms for RDX-induced neurological disorder and neurotoxicity.
C1 [Deng, Youping; Wang, Zhaohui; Liu, Chang] Wuhan Univ Sci & Technol, Wuhan 430081, Hubei, Peoples R China.
[Deng, Youping; Ai, Junmei] Rush Univ, Med Ctr, Dept Internal Med & Biochem, Chicago, IL 60612 USA.
[Guan, Xin] Bristol Bay Native Corp, Vicksburg, MS 39180 USA.
[Yan, Bin] Hong Kong Baptist Univ, Dept Biol, Kowloon, Hong Kong, Peoples R China.
[Yan, Bin] Univ Hong Kong, LKS Fac Med, Stem Cell & Regenerat Med Consortium, Hong Kong, Hong Kong, Peoples R China.
[Yan, Bin] Univ Hong Kong, Dept Physiol, Hong Kong, Hong Kong, Peoples R China.
[Zhang, Daqin] Soochow Univ, Ctr Syst Biol, Sch Math Sci, Suzhou 215006, Jiangsu, Peoples R China.
[Wilbanks, Mitch S.; Escalon, Barbara Lynn; Perkins, Edward J.] US Army, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Meyers, Sharon A.] NE Louisiana Univ, Sch Pharm, Monroe, LA 71209 USA.
[Wang, Zhaohui] Wuhan Univ Sci & Technol, Sch Comp Sci & Technol, Wuhan 430081, Hubei, Peoples R China.
[Yang, Mary Qu] Univ Arkansas, George W Donaghey Coll Engn & Informat Technol, MidSouth Bioinformat Ctr, Dept Informat Sci, Little Rock, AR 72204 USA.
[Yang, Mary Qu] Univ Arkansas, Joint Bioinformat Grad Program, Little Rock, AR 72204 USA.
[Yang, Mary Qu] Univ Arkansas Med Sci, Little Rock, AR 72204 USA.
RP Deng, YP (reprint author), Wuhan Univ Sci & Technol, Wuhan 430081, Hubei, Peoples R China.
EM youping_deng@rush.edu
FU Natural Science Foundation Hubei Province of China [2011CDB236]; United
States National Institutes of Health (NIH); NIH/NIGMS [5P20GM10342913];
ASTA [15-B-23]; NIH/NCI [R21CA164764]
FX This work and its publication were supported by research grants from
Natural Science Foundation Hubei Province of China (2011CDB236) and
United States National Institutes of Health (NIH). MQY was supported by
NIH/NIGMS 5P20GM10342913 and ASTA award # 15-B-23. YD was supported by
NIH/NCI R21CA164764.
NR 43
TC 6
Z9 6
U1 0
U2 3
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2164
J9 BMC GENOMICS
JI BMC Genomics
PD DEC 16
PY 2014
VL 15
SU 11
AR S1
DI 10.1186/1471-2164-15-S11-S1
PG 12
WC Biotechnology & Applied Microbiology; Genetics & Heredity
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA CH4CE
UT WOS:000353978200002
PM 25559034
ER
PT J
AU Ruiz, S
Wolfe, DN
AF Ruiz, Sara
Wolfe, Daniel N.
TI Vaccination against Q fever for biodefense and public health indications
SO FRONTIERS IN MICROBIOLOGY
LA English
DT Article
DE Q fever; vaccine; biodefense; Coxiella; epidemiology
ID COXIELLA-BURNETII INFECTION; METHANOL RESIDUE VACCINE; HIGH-RISK
PATIENTS; PHASE-I; SEROEPIDEMIOLOGICAL SURVEY; IMMUNE-RESPONSES;
BLOOD-DONORS; US MILITARY; BALB/C MICE; SEROPREVALENCE
AB Coxiella bumetii is the etiological agent of Q fever, a disease that is often spread to humans via inhalational exposure to the bacteria from contaminated agricultural sources. Outbreaks have been observed all over the world with larger foci generating interest in vaccination programs, most notably in Australia and the Netherlands. Importantly, exposure rates among military personnel deployed to the Middle East can be relatively high as measured by seroconversion to C. bumetii-specific antibodies. Q fever has been of interest to the biodefense community over the years due to its low infectious dose and environmental stability. Recent advances in cell-free growth and genetics of C. bumetii also make this organism easier to culture and manipulate. While there is a vaccine that is licensed for use in Australia, the combination of biodefense- and public health-related issues associated with Q fever warrant the development of a safer and more effective vaccine against this disease.
C1 [Ruiz, Sara] US Army Med Res Inst Infect Dis, Ctr Aerobiol Sci, Ft Detrick, MD USA.
[Wolfe, Daniel N.] Def Threat Reduct Agcy, Chem Biol Technol Dept, Ft Belvoir, VA 22060 USA.
RP Wolfe, DN (reprint author), Def Threat Reduct Agcy, Chem Biol Technol Dept, 8725 John Kingman Rd, Ft Belvoir, VA 22060 USA.
EM daniel.wolfe@dtra.mil
NR 85
TC 1
Z9 1
U1 2
U2 23
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1664-302X
J9 FRONT MICROBIOL
JI Front. Microbiol.
PD DEC 16
PY 2014
VL 5
AR 726
DI 10.3389/fmicb.2014.00726
PG 7
WC Microbiology
SC Microbiology
GA AX9TD
UT WOS:000347244000001
PM 25566235
ER
PT J
AU Hulse, EJ
Davies, JOJ
Simpson, AJ
Sciuto, AM
Eddleston, M
AF Hulse, Elspeth J.
Davies, James O. J.
Simpson, A. John
Sciuto, Alfred M.
Eddleston, Michael
TI Respiratory Complications of Organophosphorus Nerve Agent and
Insecticide Poisoning Implications for Respiratory and Critical Care
SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
LA English
DT Review
DE Organophosphorus; insecticide; nerve agent; critical care
ID ACUTE LUNG INJURY; VENTILATOR-ASSOCIATED PNEUMONIA; MUSCARINIC
ACETYLCHOLINE-RECEPTORS; RANDOMIZED CONTROLLED-TRIAL;
GASTRIC-ACID-SECRETION; INTERMEDIATE SYNDROME; DISTRESS-SYNDROME;
PULMONARY-EDEMA; ASPIRATION PNEUMONITIS; INHALATION TOXICITY
AB Organophosphorus (OP) compound poisoning is a major global public health problem. Acute OP insecticide self-poisoning kills over 200,000 people every year, the majority from self-harm in rural Asia. Highly toxic OP nerve agents (e.g., sarin) are a significant current terrorist threat, as shown by attacks in Damascus during 2013. These anticholinesterase compounds are classically considered to cause an acute cholinergic syndrome with decreased consciousness, respiratory failure, and, in the case of insecticides, a delayed intermediate syndrome that requires prolonged ventilation. Acute respiratory failure, by central and peripheral mechanisms, is the primary-cause of death in most cases, However, preclinical and clinical research over the last two decades has indicated a more complex picture of respiratory complications after OP insecticide poisoning, including onset of delayed neuromuscular junction dysfunction during the cholinergic syndrome, aspiration causing pneumonia and acute respiratory distress syndrome, and the involvement of solvents in OP toxicity. The treatment of OP poisoning has not changed over the last 50 years. However, a better understanding of the multiple respiratory complications of OP poisoning offers additional therapeutic opportunities.
C1 [Hulse, Elspeth J.; Eddleston, Michael] Univ Edinburgh, BHF Ctr Cardiovasc Sci, Edinburgh, Midlothian, Scotland.
[Hulse, Elspeth J.; Davies, James O. J.; Eddleston, Michael] Univ Peradeniya, South Asian Clin Toxicol Res Collaborat, Peradeniya, Sri Lanka.
[Davies, James O. J.] Univ Oxford, Weatherall Inst Mol Med, Oxford, England.
[Simpson, A. John] Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.
[Sciuto, Alfred M.] US Army Med Res Inst Chem Def, Analyt Toxicol Div, Aberdeen Proving Ground, MD USA.
RP Eddleston, M (reprint author), Queens Med Res Inst, E3-20,47 Little France Crescent, Edinburgh EH16 4TJ, Midlothian, Scotland.
EM m.eddleston@ed.ac.uk
FU Wellcome Trust [063560, 085979, 090886]
FX Supported by Wellcome Trust grants 063560, 085979, and 090886.
NR 115
TC 8
Z9 14
U1 2
U2 17
PU AMER THORACIC SOC
PI NEW YORK
PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA
SN 1073-449X
EI 1535-4970
J9 AM J RESP CRIT CARE
JI Am. J. Respir. Crit. Care Med.
PD DEC 15
PY 2014
VL 190
IS 12
BP 1342
EP 1354
DI 10.1164/rccm.201406-1150CI
PG 13
WC Critical Care Medicine; Respiratory System
SC General & Internal Medicine; Respiratory System
GA AX4IG
UT WOS:000346896000009
PM 25419614
ER
PT J
AU Martin, WA
Nestler, CC
Wynter, M
Larson, SL
AF Martin, W. Andy
Nestler, Catherine C.
Wynter, Michelle
Larson, Steven L.
TI Bullet on bullet fragmentation profile in soils
SO JOURNAL OF ENVIRONMENTAL MANAGEMENT
LA English
DT Article
DE Pb; Sb; Cu; Fragmentation; Bullet; Soil
ID ANTIMONY; RANGE; LEAD
AB Lead-antimony alloy slugs encased in a brass jackets are common small arms caliber ammunition used for training and target practice. When small caliber ammunition is fired at testing and training ranges, these metals-some of which are toxic-are introduced into the environment. Research was conducted on the effects of bullet on bullet impacts and the resulting bullet fragmentation. The extent of bullet fragmentation, among other factors, affects the formation of mobile metal species from small arms firing ranges. Bullet on bullet impact can increase the surface area to mass ratio of the bullet metal alloys in the soil. The solubility of a metal is typically associated with the specific corrosion rate in the berm environment which is dependent on the surface area of the fragments. The purpose of the study was to analyze the bullet on bullet impact effects in six soil types. Changes in the metal distribution as a result of bullet impact was evaluated through sieve analysis and changes in the particle size distribution. The bullet on bullet impact observed in this study demonstrated a significant and observable shift in the fragmentation profiles for the lead, antimony, and copper in soils after shooting an average of 1050 tungsten-nylon bullets into the legacy lead soils. This study provides new information to assist with determining the potential environmental fate, transport, and environmental availability associated with constant bullet on bullet impact at testing and training ranges. Published by Elsevier Ltd.
C1 [Martin, W. Andy; Wynter, Michelle; Larson, Steven L.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
[Martin, W. Andy] Purdue Univ, Dept Agron, W Lafayette, IN 47907 USA.
[Nestler, Catherine C.] Appl Res Associates Inc, Vicksburg, MS 39180 USA.
RP Martin, WA (reprint author), Purdue Univ, Dept Agron, W Lafayette, IN 47907 USA.
EM Andy.Martin@usace.army.mil
FU U.S. Army Armament Research, Development and Engineering Center
FX This study would not be possible without the financial support of the
U.S. Army Armament Research, Development and Engineering Center.
Analytical and technical support was provided by Mr. Chris Griggs and
Dr. Chuck Weiss of the U.S. Army Engineer Research and Development
Center. Citation of trade names in this manuscript does not constitute
an official endorsement or approval of the use of such commercial
products. This manuscript was approved for public release by the Chief
of Engineers.
NR 14
TC 1
Z9 1
U1 2
U2 29
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0301-4797
EI 1095-8630
J9 J ENVIRON MANAGE
JI J. Environ. Manage.
PD DEC 15
PY 2014
VL 146
BP 369
EP 372
DI 10.1016/j.jenvman.2014.04.041
PG 4
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA AR5HA
UT WOS:000343614400040
PM 25201767
ER
PT J
AU Singamaneni, SR
Fan, W
Prater, JT
Narayan, J
AF Singamaneni, Srinivasa Rao
Fan, Wu
Prater, J. T.
Narayan, J.
TI Magnetic properties of BaTiO3/La0.7Sr0.3MnO3 thin films integrated on
Si(100)
SO JOURNAL OF APPLIED PHYSICS
LA English
DT Article
ID PULSED-LASER DEPOSITION; BATIO3 FILMS; SILICON; HETEROSTRUCTURES; GROWTH
AB Two-phase multiferroic heterostructures composed of room-temperature ferroelectric BaTiO3 (BTO) and ferromagnetic La0.7Sr0.3MnO3 (LSMO) epitaxial thin films were grown on technologically important substrate Si (100). Bilayers of BTO/LSMO thin films display ferromagnetic Curie transition temperatures of similar to 350K, close to the bulk value, which are independent of BTO films thickness in the range of 25-100 nm. Discontinuous magnetization jumps associated with BTO structural transitions were suppressed in M(T) curves, probably due to substrate clamping effect. Interestingly, at cryogenic temperatures, the BTO/LSMO structure with BTO layer thickness of 100 nm shows almost 2-fold higher magnetic coercive field, 3-fold reduction in saturation magnetization, and improved squareness compared to the sample without BTO. We believe that the strong in-plane spin pinning of the ferromagnetic layer induced by BTO layer at BTO/LSMO interface could cause such changes in magnetic properties. This work forms a significant step forward in the integration of two-phase multiferroic heterostructures for CMOS applications. (C) 2014 AIP Publishing LLC.
C1 [Singamaneni, Srinivasa Rao; Prater, J. T.] Army Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA.
[Singamaneni, Srinivasa Rao; Fan, Wu; Prater, J. T.; Narayan, J.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA.
RP Singamaneni, SR (reprint author), Army Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA.
EM ssingam@ncsu.edu
OI , fan/0000-0001-5000-0592
FU National Academy of Science (NAS), USA of NRC; Army Research Office
[W911NF-04-D-0003]; State of North Carolina; National Science Foundation
FX S.R.S. acknowledges financial support from the National Academy of
Science (NAS), USA in the form of NRC postdoctoral research associate
fellowship. We thank Chrstian Binek, University of Nebraska and N. D.
Mathur, University of Cambridge for stimulating discussion. Also, the
authors are pleased to acknowledge the support of the Army Research
Office under Grant W911NF-04-D-0003. Also, the authors acknowledge the
use of the Analytical Instrumentation Facility (AIF) at North Carolina
State University, which was supported by the State of North Carolina and
the National Science Foundation.
NR 23
TC 5
Z9 5
U1 3
U2 53
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0021-8979
EI 1089-7550
J9 J APPL PHYS
JI J. Appl. Phys.
PD DEC 14
PY 2014
VL 116
IS 22
AR 224104
DI 10.1063/1.4903322
PG 6
WC Physics, Applied
SC Physics
GA AW4QR
UT WOS:000346266300042
ER
PT J
AU Wali, S
Gupta, R
Veselenak, RL
Li, YS
Yu, JJ
Murthy, AK
Cap, AP
Guentzel, MN
Chambers, JP
Zhong, GM
Rank, RG
Pyles, RB
Arulanandam, BP
AF Wali, Shradha
Gupta, Rishein
Veselenak, Ronald L.
Li, Yansong
Yu, Jieh-Juen
Murthy, Ashlesh K.
Cap, Andrew P.
Guentzel, M. Neal
Chambers, James P.
Zhong, Guangming
Rank, Roger G.
Pyles, Richard B.
Arulanandam, Bernard P.
TI Use of a Guinea Pig-Specific Transcriptome Array for Evaluation of
Protective Immunity against Genital Chlamydial Infection following
Intranasal Vaccination in Guinea Pigs
SO PLOS ONE
LA English
DT Article
ID CD4(+) T-CELLS; INCLUSION CONJUNCTIVITIS; TRACHOMATIS INFECTION;
MURIDARUM INFECTION; TRACT INFECTION; MOUSE PNEUMONITIS; ANIMAL-MODELS;
HOST RESPONSE; REPRODUCTIVE-TRACT; IFN-GAMMA
AB Guinea pigs have been used as a second animal model to validate putative anti-chlamydial vaccine candidates tested in mice. However, the lack of guinea pig-specific reagents has limited the utility of this animal model in Chlamydia sp. vaccine studies. Using a novel guinea pig-specific transcriptome array, we determined correlates of protection in guinea pigs vaccinated with Chlamydia caviae (C. caviae) via the intranasal route, previously reported by us and others to provide robust antigen specific immunity against subsequent intravaginal challenge. C. caviae vaccinated guinea pigs resolved genital infection by day 3 post challenge. In contrast, mock vaccinated animals continued to shed viable Chlamydia up to day 18 post challenge. Importantly, at day 80 post challenge, vaccinated guinea pigs experienced significantly reduced genital pathology - a sequelae of genital chlamydial infections, in comparison to mock vaccinated guinea pigs. Sera from vaccinated guinea pigs displayed antigen specific IgG responses and increased IgG1 and IgG2 titers capable of neutralizing GPIC in vitro.
C1 [Wali, Shradha; Gupta, Rishein; Yu, Jieh-Juen; Guentzel, M. Neal; Chambers, James P.; Arulanandam, Bernard P.] Univ Texas San Antonio, South Texas Ctr Emerging Infect Dis, San Antonio, TX 78249 USA.
[Wali, Shradha; Gupta, Rishein; Yu, Jieh-Juen; Guentzel, M. Neal; Chambers, James P.; Arulanandam, Bernard P.] Univ Texas San Antonio, Ctr Excellence Infect Genom, San Antonio, TX 78249 USA.
[Veselenak, Ronald L.; Pyles, Richard B.] Univ Texas Med Branch, Dept Pediat, Galveston, TX 77555 USA.
[Veselenak, Ronald L.; Pyles, Richard B.] Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA.
[Li, Yansong; Cap, Andrew P.] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Murthy, Ashlesh K.] Midwestern Univ, Dept Pathol, Downers Grove, IL 60148 USA.
[Zhong, Guangming] Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol & Immunol, San Antonio, TX 78229 USA.
[Rank, Roger G.] Univ Arkansas Med Sci, Dept Microbiol & Immunol, Little Rock, AR 72202 USA.
[Rank, Roger G.] Arkansas Childrens Hosp, Res Inst, Little Rock, AR 72202 USA.
RP Arulanandam, BP (reprint author), Univ Texas San Antonio, South Texas Ctr Emerging Infect Dis, One UTSA Circle, San Antonio, TX 78249 USA.
EM Bernard.Arulanandam@utsa.edu
OI Wali, Shradha/0000-0002-6077-7618
FU National Institutes of Health [1RO1AI074860, 1R03AI092621-01]; Army
Research Office of the Department of Defense [W911NF-11-1-0136]
FX This work was supported by National Institutes of Health Grant
1RO1AI074860, 1R03AI092621-01 and the Army Research Office of the
Department of Defense under Contract No. W911NF-11-1-0136. The funders
had no role in study design, data collection and analysis, decision to
publish, or preparation of the manuscript.
NR 73
TC 1
Z9 1
U1 0
U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD DEC 11
PY 2014
VL 9
IS 12
AR e114261
DI 10.1371/journal.pone.0114261
PG 21
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AX8FY
UT WOS:000347146700018
PM 25502875
ER
PT J
AU Haus, T
Palunko, I
Tolic, D
Bogdan, S
Lewis, FL
Mikulski, DG
AF Haus, Tomislav
Palunko, Ivana
Tolic, Domagoj
Bogdan, Stjepan
Lewis, Frank L.
Mikulski, Dariusz G.
TI Trust-based self-organising network control
SO IET CONTROL THEORY AND APPLICATIONS
LA English
DT Article
DE multi-agent systems; network theory (graphs); decentralised control;
networked control systems; adaptive control; convergence; directed
graphs; decentralised trust-based self-organising network control; trust
dependent consensus-based mechanism; adaptive control; trust value
negotiation; convergence; adaptive mechanism; autonomous agents;
decentralised formation control; directed weighted graph; network
topology
ID CONSENSUS; COORDINATION; COOPERATION; SYSTEMS; AGENTS
AB This study proposes a mechanism for decentralised trust-based self-organising network control. The driving force of this work is the idea that some agents are more versed in certain tasks, such as communication, data processing, localisation or trajectory tracking, at a given moment. The author's control objective is to reach an agreement throughout the network regarding each agent's suitability for a certain task. In particular, this study is interested in cultivating network trust towards each agent. Trust values reflect the reputation of each agent within the group. The authors initialise individual trust values towards each agent based on local observations and observations received from the neighbours. Next, a trust-dependent consensus-based mechanism is employed. Since this mechanism is decentralised, scenarios with unequal trusts values towards one agent need to be handled with caution in order not to compromise the collective behaviour. To that end, they employ adaptive control concepts when negotiating trust values. They formally prove convergence of the proposed adaptive mechanism for the network topologies that can be represented with directed weighted graphs. The proposed mechanism is illustrated through a case study of decentralised formation control of autonomous agents. They provide an in-depth analysis of several possible scenarios regarding the proposed control structure.
C1 [Haus, Tomislav; Palunko, Ivana; Tolic, Domagoj; Bogdan, Stjepan] Univ Zagreb, Fac Elect Engn & Comp, Zagreb 10000, Croatia.
[Lewis, Frank L.] Univ Texas Arlington, Automat & Robot Res Inst, Ft Worth, TX 76118 USA.
[Mikulski, Dariusz G.] US Army TARDEC, Warren, MI 48397 USA.
RP Haus, T (reprint author), Univ Zagreb, Fac Elect Engn & Comp, Unska 3, Zagreb 10000, Croatia.
EM tomislav.haus@fer.hr
FU Air Force Research Laboratory [FA8655-13-1-3055]; EU-ICT ASSISIbf
[601074]
FX This material is based on research sponsored by the Air Force Research
Laboratory, under agreement number FA8655-13-1-3055. The U.S. Government
is authorised to reproduce and distribute reprints for Governmental
purposes notwithstanding any copyright notation thereon. The views and
conclusions contained herein are those of the authors and should not be
interpreted as necessarily representing the official policies or
endorsements, either expressed or implied, of the Air Force Research
Laboratory or the U.S. Government. This work is partially supported by
EU-ICT ASSISIbf, grant number 601074.
NR 18
TC 2
Z9 2
U1 3
U2 14
PU INST ENGINEERING TECHNOLOGY-IET
PI HERTFORD
PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD SG1 2AY, ENGLAND
SN 1751-8644
EI 1751-8652
J9 IET CONTROL THEORY A
JI IET Contr. Theory Appl.
PD DEC 11
PY 2014
VL 8
IS 18
SI SI
BP 2126
EP 2135
DI 10.1049/iet-cta.2014.0333
PG 10
WC Automation & Control Systems; Engineering, Electrical & Electronic;
Instruments & Instrumentation
SC Automation & Control Systems; Engineering; Instruments & Instrumentation
GA AW1XT
UT WOS:000346082700002
ER
PT J
AU Bartolucci, SF
Supan, KE
Warrender, JM
Davis, CE
La Beaud, L
Knowles, K
Wiggins, JS
AF Bartolucci, Stephen F.
Supan, Karen E.
Warrender, Jeffrey M.
Davis, Christopher E.
La Beaud, Lawrence
Knowles, Kyler
Wiggins, Jeffrey S.
TI Laser-induced thermo-oxidative degradation of carbon
nanotube/polypropylene nanocomposites
SO COMPOSITES SCIENCE AND TECHNOLOGY
LA English
DT Article
DE Nanocomposites; Carbon nanotubes; Nanoclays; Thermal properties;
High-temperature properties
ID LAYERED-SILICATE NANOCOMPOSITES; FLAMMABILITY PROPERTIES; POLYMER
NANOCOMPOSITES; FIRE BEHAVIOR; NANOTUBE NANOCOMPOSITES; POLYPROPYLENE;
COMPOSITES; DISPERSION; PYROLYSIS; COATINGS
AB Nanocomposites of multi-walled carbon nanotubes and polypropylene were fabricated using twin screw extrusion and subjected to heating rates on the order of 100,000 degrees per second using laser pulse heating. Raman and infrared spectroscopy, as well as electron microscopy observations, showed that the nanotubes retain their structure and that a nanotube-rich layer formed at the surface of the composites during laser heating. By varying the weight fraction of filler in the composites, a 54% reduction in mass loss per laser pulse was achieved, compared to the pure polymer. The nanotube composites also displayed lower mass loss than nanoclay composites under the same conditions, despite having a significantly lower weight fraction of additive. Further reduction in mass loss per laser pulse was achieved in solvent-processed samples, which appear to have better dispersion than the extrusion-processed composites. We attribute these observations to the formation of a nanotube network formed on the surface, which acts as a protective barrier, slowing the degradation of the underlying polymer. Several observations made in this study are consistent with those reported in previously published slow heating rate studies, showing that while some phenomena are unique to transient heating, there are some commonalities between the two regimes. Published by Elsevier Ltd.
C1 [Bartolucci, Stephen F.; Supan, Karen E.; Warrender, Jeffrey M.; Davis, Christopher E.] US Army, Benet Labs, Armaments Res Dev & Engn Ctr, Watervliet, NY 12189 USA.
[Supan, Karen E.] Norwich Univ, Dept Mech Engn, Northfield, VT 05663 USA.
[Davis, Christopher E.] MIT, Dept Chem Engn, Cambridge, MA 02139 USA.
[La Beaud, Lawrence; Knowles, Kyler; Wiggins, Jeffrey S.] Univ So Mississippi, Sch Polymers & High Performance Mat, Hattiesburg, MS 39406 USA.
RP Bartolucci, SF (reprint author), US Army, Benet Labs, Armaments Res Dev & Engn Ctr, 1 Buffington St, Watervliet, NY 12189 USA.
OI Knowles, Kyler/0000-0002-0743-6056
NR 30
TC 2
Z9 2
U1 3
U2 13
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0266-3538
EI 1879-1050
J9 COMPOS SCI TECHNOL
JI Compos. Sci. Technol.
PD DEC 10
PY 2014
VL 105
BP 166
EP 173
DI 10.1016/j.compscitech.2014.09.018
PG 8
WC Materials Science, Composites
SC Materials Science
GA AX5BZ
UT WOS:000346943400021
ER
PT J
AU Xu, K
AF Xu, Kang
TI Electrolytes and Interphases in Li-Ion Batteries and Beyond
SO CHEMICAL REVIEWS
LA English
DT Review
ID CARBONATE-BASED ELECTROLYTES; LITHIUM SECONDARY BATTERIES; GRAPHITE
NEGATIVE-ELECTRODE; SURFACE-FILM FORMATION; RECHARGEABLE MAGNESIUM
BATTERIES; LOW-TEMPERATURE PERFORMANCE; SOLID POLYMER ELECTROLYTES;
ATOMIC LAYER DEPOSITION; EDGE PLANE GRAPHITE; RAY
PHOTOELECTRON-SPECTROSCOPY
C1 [Xu, Kang] US Army Res Lab, Sensor & Elect Directorate, Energy & Power Div, Electrochem Branch, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
RP Xu, K (reprint author), US Army Res Lab, Sensor & Elect Directorate, Energy & Power Div, Electrochem Branch, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM conrad.k.xu.civ@mail.mil
NR 826
TC 411
Z9 414
U1 193
U2 923
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0009-2665
EI 1520-6890
J9 CHEM REV
JI Chem. Rev.
PD DEC 10
PY 2014
VL 114
IS 23
BP 11503
EP 11618
DI 10.1021/cr500003w
PG 116
WC Chemistry, Multidisciplinary
SC Chemistry
GA AW5OC
UT WOS:000346323200004
PM 25351820
ER
PT J
AU Bromberg, L
Pomerantz, N
Schreuder-Gibson, H
Hatton, TA
AF Bromberg, Lev
Pomerantz, Natalie
Schreuder-Gibson, Heidi
Hatton, T. Alan
TI Degradation of Chemical Threats by Brominated Polymer Networks
SO INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
LA English
DT Article
ID NERVE AGENT VX; POLY(ETHYLENE-ALT-MALEIC ANHYDRIDE) COPOLYMER;
N-BROMOSUCCINIMIDE; WARFARE AGENTS; ELECTROCHEMICAL REDUCTION;
ANTIMICROBIAL PAINTS; AMBIENT CONDITIONS; OXIDATION; REAGENT; HYDROLYSIS
AB Poly(N-bromomaleimide) (PMAi-Br), poly(N-vinylpyrrolidone)-bromine adducts (PVPBr), and poly(ethylene-alt-N-bromomaleimide) (PEMAi-Br) and their cross-linked networks are introduced as reactive, self-decontaminating components of protective barriers. Synthetic routes toward polymaleimides include free-radical copolymerization of maleimide with divinyl cross-linkers as well as amidation of poly(ethylene-alt-maleic anhydride) with urea. The polymers are brominated by bromine in carbon tetrachloride or by copper(II) bromide in dimethylformamide, with the active bromine contents up to and above 4 mequiv/g, or >30 wt %. The brominated polymer networks exhibit considerable swelling in water and possess reversible redox peak potentials in cyclic voltammetry experiments due to the redox reactions of the bromine present in the polymer structures. In acidic aqueous media, PVPBr, PMAi-co-DVB-Br, and PEMAi-Br materials are able to degrade 100% of hydrazine, monomethylhydrazine, and 1,1-dimethylhydrazine down to concentrations below detectable levels of 0.150.25 mM. The hydrazine is converted to nitrogen gas. The insecticide malathion, tested as a simulant of a combat warfare agent VX, is efficiently and selectively oxidized to malaoxon in the presence of the brominated networks, whereas 2-(chloroethyl)ethyl sulfide (CEES), a simulant of the sulfur mustard agent, is rapidly oxidized, in both vapor and liquid states, into its less-toxic sulfone derivative, 1-chloro-2-(ethylsulfinyl)ethane (CEESO), with the only side product being 1,2-bis(ethylthio)ethane. The oxidation of CEES is proven to be selective, in that no toxic overoxidized CEES analogue, 1-chloro-2-(ethylsulfonyl)ethane, is formed. The developed brominated polymer networks are versatile materials with potential applications in coatings, filters, fabrics, and sorbents.
C1 [Bromberg, Lev; Hatton, T. Alan] MIT, Dept Chem Engn, Cambridge, MA 02139 USA.
[Pomerantz, Natalie; Schreuder-Gibson, Heidi] US Army Natick Soldier Res, Ctr Dev & Engn, Mat & Def Sci Div, Natick, MA 01760 USA.
RP Hatton, TA (reprint author), MIT, Dept Chem Engn, Cambridge, MA 02139 USA.
EM tahatton@mit.edu
FU Defense Threat Reduction Agency under Army Research Office
[W911NF-13-D-0001]
FX This work was supported by the Defense Threat Reduction Agency under
Army Research Office Grant W911NF-13-D-0001.
NR 87
TC 12
Z9 12
U1 1
U2 42
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0888-5885
J9 IND ENG CHEM RES
JI Ind. Eng. Chem. Res.
PD DEC 10
PY 2014
VL 53
IS 49
BP 18761
EP 18774
DI 10.1021/ie501055g
PG 14
WC Engineering, Chemical
SC Engineering
GA AW5NR
UT WOS:000346322200018
ER
PT J
AU Wang, RL
Bencic, DC
Garcia-Reyero, N
Perkins, EJ
Villeneuve, DL
Ankley, GT
Biales, AD
AF Wang, Rong-Lin
Bencic, David C.
Garcia-Reyero, Natalia
Perkins, Edward J.
Villeneuve, Daniel L.
Ankley, Gerald T.
Biales, Adam D.
TI Natural Variation in Fish Transcriptomes: Comparative Analysis of the
Fathead Minnow (Pimephales promelas) and Zebrafish (Danio rerio)
SO PLOS ONE
LA English
DT Article
ID GENE-EXPRESSION SIGNATURES; NOISE; CONSEQUENCES; MECHANISMS; PLATFORMS;
MOLECULES; EVOLUTION; VARIANCE; PROFILES; PATTERNS
AB Fathead minnow and zebrafish are among the most intensively studied fish species in environmental toxicogenomics. To aid the assessment and interpretation of subtle transcriptomic effects from treatment conditions of interest, better characterization and understanding are needed for natural variation in gene expression among fish individuals from lab cultures. Leveraging the transcriptomics data from a number of our toxicogenomics studies conducted over the years, we conducted a meta-analysis of nearly 600 microarrays generated from the ovary tissue of untreated, reproductively mature fathead minnow and zebrafish samples. As expected, there was considerable batch-to-batch transcriptomic variation; this "batch-effect'' appeared to differentially impact subsets of fish transcriptomes in a nonsystematic way. Temporally more closely spaced batches tended to share a greater transcriptomic similarity among one another. The overall level of within-batch variation was quite low in fish ovary tissue, making it a suitable system for studying chemical stressors with subtle biological effects. The observed differences in the within-batch variability of gene expression, at the levels of both individual genes and pathways, were probably both technical and biological. This suggests that biological interpretation and prioritization of genes and pathways targeted by experimental conditions should take into account both their intrinsic variability and the size of induced transcriptional changes. There was significant conservation of both the genomes and transcriptomes between fathead minnow and zebrafish. The high degree of conservation offers promising opportunities in not only studying fish molecular responses to environmental stressors by a comparative biology approach, but also effective sharing of a large amount of existing public transcriptomics data for developing toxicogenomics applications.
C1 [Wang, Rong-Lin; Bencic, David C.; Biales, Adam D.] US EPA, Ecol Exposure Res Div, Natl Exposure Res Lab, Cincinnati, OH 45268 USA.
[Garcia-Reyero, Natalia] Mississippi State Univ, Inst Genom Biocomp & Biotechnol, Starkville, MS USA.
[Perkins, Edward J.] US Army Corps Engn, US Army Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS USA.
[Wang, Rong-Lin; Villeneuve, Daniel L.; Ankley, Gerald T.] US EPA, Midcontinent Ecol Div, Natl Hlth & Environm Effects Res Lab, Duluth, MN USA.
RP Wang, RL (reprint author), US EPA, Ecol Exposure Res Div, Natl Exposure Res Lab, Cincinnati, OH 45268 USA.
EM wang.rong-lin@epa.gov
FU U.S. EPA; U.S. Army [BAA 11-4838]
FX Funding was provided by U.S. EPA and U.S. Army (grant BAA 11-4838). The
manuscript has been approved for publication by U.S. EPA and U.S. Army
Corps Chief of Engineers. The funders had no role in study design, data
collection and analysis, or preparation of the manuscript.
NR 56
TC 8
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U1 3
U2 27
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD DEC 10
PY 2014
VL 9
IS 12
AR e114178
DI 10.1371/journal.pone.0114178
PG 24
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AW9YP
UT WOS:000346611400034
PM 25493933
ER
PT J
AU Mion, T
Potrepka, DM
Crowne, FJ
Tauber, A
Tidrow, SC
AF Mion, Thomas
Potrepka, D. M.
Crowne, F. J.
Tauber, A.
Tidrow, Steven C.
TI Dielectric and X-ray Diffraction Analysis of Ba(Ga,Ta)(0.05)Ti0.90O3
SO FERROELECTRICS
LA English
DT Article
DE BaTiO3; dopant; dielectric; Rietveld refinement; Barium titanate;
dipole-like; X-ray diffraction; substitution; SEM
ID FERROELECTRIC MATERIALS; THERMAL-EXPANSION; THIN-FILMS; MICROWAVE;
PHASE; POLARIZABILITIES; PEROVSKITES; TECHNOLOGY; CAPACITORS; CERAMICS
AB Ba(Ga,Ta)(0.05)Ti0.90O3, a B-site dipole-like substituted material is investigated for structural phase transitions over the temperature range 30 to 900 degrees C using x-ray diffraction. Rietveld refinement of the data suggests the material to be Pm
[GRAPHICS]
m (cubic) from 200 to 900 degrees C, P4/mmm (tetragonal) from 30 to 200 degrees C with phases similar to those of BaTiO3 [12]. Average grain size determined using scanning electron microscopy is 650nm. Measurements of dielectric properties from -50 to 120 degrees C and over a frequency range of 10Hz to 2MHz show a relatively flat dielectric constant that is electric-field tunable indicating that Ba(Ga,Ta)(0.05)Ti0.90O3 is a reasonable candidate for frequency agile components.
C1 [Mion, Thomas; Tidrow, Steven C.] Univ Texas Pan Amer, Dept Phys & Geol, Edinburg, TX 78539 USA.
[Potrepka, D. M.; Crowne, F. J.] US Army Res Lab, Adelphi, MD 20783 USA.
[Tauber, A.] Geocenters Inc, US Army Res Lab, Washington, DC USA.
RP Tidrow, SC (reprint author), Univ Texas Pan Amer, Dept Phys & Geol, Edinburg, TX 78539 USA.
EM sctidrow@utpa.edu
FU U.S. Army Research Laboratory; U.S. Army Research Office
[W911NF-08-1-0353]
FX This work was supported in part by the U.S. Army Research Laboratory and
the U.S. Army Research Office through contract number W911NF-08-1-0353.
NR 31
TC 1
Z9 1
U1 1
U2 10
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0015-0193
EI 1563-5112
J9 FERROELECTRICS
JI Ferroelectrics
PD DEC 10
PY 2014
VL 473
IS 1
BP 13
EP 23
DI 10.1080/00150193.2014.974431
PG 11
WC Materials Science, Multidisciplinary; Physics, Condensed Matter
SC Materials Science; Physics
GA AW3MF
UT WOS:000346190100002
ER
PT J
AU West, BJ
AF West, Bruce J.
TI A mathematics for medicine: The Network Effect
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE physiologic networks; statistical extrema; complexity and disease;
fractional calculus; complexity hypothesis
ID HEART-RATE; NEURONAL AVALANCHES; FRACTIONAL DYNAMICS;
STOCHASTIC-PROCESS; BRONCHIAL TREE; RANDOM-WALKS; FLUCTUATIONS;
TURBULENCE; LONGEVITY; NOISE
AB The theory of medicine and its complement systems biology are intended to explain the workings of the large number of mutually interdependent complex physiologic networks in the human body and to apply that understanding to maintaining the functions for which nature designed them. Therefore, when what had originally been made as a simplifying assumption or a working hypothesis becomes foundational to understanding the operation of physiologic networks it is in the best interests of science to replace or at least update that assumption. The replacement process requires, among other things, an evaluation of how the new hypothesis affects modern day understanding of medical science. This paper identifies linear dynamics and Normal statistics as being such arcane assumptions and explores some implications of their retirement. Specifically we explore replacing Normal with fractal statistics and examine how the latter are related to non-linear dynamics and chaos theory. The observed ubiquity of inverse power laws in physiology entails the need for a new calculus, one that describes the dynamics of fractional phenomena and captures the fractal properties of the statistics of physiological time series. We identify these properties as a necessary consequence of the complexity resulting from the network dynamics and refer to them collectively as The Network Effect.
C1 Army Res Off, Math & Informat Sci Directorate, Res Triangle Pk, NC 27709 USA.
RP West, BJ (reprint author), Army Res Off, Math & Informat Sci Directorate, 4300 S Miami Blvd, Res Triangle Pk, NC 27709 USA.
EM bruce.j.west@att.net
FU Army Research Office
FX I would like to thank Drs. R. Magin, J. Milton, I. Osorio, and D.
Sornette for reading an early version of the paper and making
constructive suggestions for its improvements and M. Bologna for
suggestions on the proof in Appendix 6.2. I, of course, retain full
responsibility for the opinions and conclusions of the paper and thank
the Army Research Office for support of this research.
NR 97
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U1 1
U2 7
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015,
SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD DEC 9
PY 2014
VL 5
AR 456
DI 10.3389/fphys.2014.00456
PG 17
WC Physiology
SC Physiology
GA AY8MJ
UT WOS:000347807500001
PM 25538622
ER
PT J
AU Bergmeier, W
Piatt, R
Petrich, BG
Monroe, D
Mackman, N
Getz, TM
AF Bergmeier, Wolfgang
Piatt, Raymond
Petrich, Brian G.
Monroe, Dougald
Mackman, Nigel
Getz, Todd M.
TI Novel Mouse Hemostasis Model for Real-Time Determination of Bleeding
Time and Hemostatic Plug Composition
SO BLOOD
LA English
DT Meeting Abstract
C1 [Bergmeier, Wolfgang; Piatt, Raymond; Monroe, Dougald; Mackman, Nigel] Univ N Carolina, Chapel Hill, NC USA.
[Petrich, Brian G.] Emory Univ, Atlanta, GA 30322 USA.
[Getz, Todd M.] US Army, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC HEMATOLOGY
PI WASHINGTON
PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA
SN 0006-4971
EI 1528-0020
J9 BLOOD
JI Blood
PD DEC 6
PY 2014
VL 124
IS 21
PG 3
WC Hematology
SC Hematology
GA CA9KQ
UT WOS:000349242704181
ER
PT J
AU Darlington, DN
Chen, J
Wu, XW
Keesee, J
Liu, B
Cap, AP
AF Darlington, Daniel N.
Chen, Jacob
Wu, Xiaowu
Keesee, Jeffery
Liu, Bin
Cap, Andrew P.
TI Whole Blood Stored at 4 degrees C for 7 Days Is Equivalent to Fresh
Whole Blood for Resuscitation of Severe Polytrauma
SO BLOOD
LA English
DT Meeting Abstract
C1 [Darlington, Daniel N.] Inst Surg Res, Jbsa Ft Sam Houston, TX USA.
[Chen, Jacob; Wu, Xiaowu; Keesee, Jeffery; Liu, Bin; Cap, Andrew P.] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX USA.
NR 0
TC 0
Z9 0
U1 1
U2 2
PU AMER SOC HEMATOLOGY
PI WASHINGTON
PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA
SN 0006-4971
EI 1528-0020
J9 BLOOD
JI Blood
PD DEC 6
PY 2014
VL 124
IS 21
PG 3
WC Hematology
SC Hematology
GA CA9KQ
UT WOS:000349242700052
ER
PT J
AU Meledeo, MA
Valenciana, MV
Rodriguez, AC
Cap, AP
AF Meledeo, Michael A.
Valenciana, Melanie V.
Rodriguez, Armando C.
Cap, Andrew P.
TI Synergistic Anticoagulant Effect of Activated Protein C and Tissue
Factor Pathway Inhibitor As a Mechanism for Acute Traumatic Coagulopathy
SO BLOOD
LA English
DT Meeting Abstract
C1 [Meledeo, Michael A.; Valenciana, Melanie V.; Rodriguez, Armando C.; Cap, Andrew P.] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC HEMATOLOGY
PI WASHINGTON
PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA
SN 0006-4971
EI 1528-0020
J9 BLOOD
JI Blood
PD DEC 6
PY 2014
VL 124
IS 21
PG 3
WC Hematology
SC Hematology
GA CA9KQ
UT WOS:000349242708142
ER
PT J
AU Pidcoke, HF
Fedyk, CG
Montgomery, RK
Hinojosa-Laborde, C
Convertino, VA
Shade, RE
Cap, AP
AF Pidcoke, Heather F.
Fedyk, Chriselda G.
Montgomery, Robbie K.
Hinojosa-Laborde, Carmen
Convertino, Victor A.
Shade, Robert E.
Cap, Andrew P.
TI Global Activation of Coagulation Is the Initiating Event of Acute
Coagulopathy of Trauma As Modeled By Hemorrhage and Lower Body Negative
Pressure in Baboons
SO BLOOD
LA English
DT Meeting Abstract
C1 [Pidcoke, Heather F.; Fedyk, Chriselda G.; Montgomery, Robbie K.; Hinojosa-Laborde, Carmen; Convertino, Victor A.; Cap, Andrew P.] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX USA.
[Shade, Robert E.] Texas Biomed Res Inst, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 4
PU AMER SOC HEMATOLOGY
PI WASHINGTON
PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA
SN 0006-4971
EI 1528-0020
J9 BLOOD
JI Blood
PD DEC 6
PY 2014
VL 124
IS 21
PG 3
WC Hematology
SC Hematology
GA CA9KQ
UT WOS:000349242702042
ER
PT J
AU Wright, ZE
Stewart, I
Sosnov, J
Pidcoke, HF
Chriselda, F
Kwan, H
Heegard, K
White, C
Chung, K
Cap, AP
AF Wright, Zachary Edward
Stewart, Ian
Sosnov, Jonathan
Pidcoke, Heather F.
Chriselda, Fedyk
Kwan, Hana
Heegard, Kelly
White, Christopher
Chung, Kevin
Cap, Andrew P.
TI A Prospective Evaluation of Acute Traumatic Coagulopathy and Effects of
Damage Control Resuscitation in Military Trauma Patients in Afghanistan
SO BLOOD
LA English
DT Meeting Abstract
C1 [Wright, Zachary Edward; Stewart, Ian; Sosnov, Jonathan; Chriselda, Fedyk; Kwan, Hana; Heegard, Kelly; White, Christopher; Chung, Kevin] US Army Inst Surg Res, Ft Sam Houston, TX USA.
[Pidcoke, Heather F.; Cap, Andrew P.] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER SOC HEMATOLOGY
PI WASHINGTON
PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA
SN 0006-4971
EI 1528-0020
J9 BLOOD
JI Blood
PD DEC 6
PY 2014
VL 124
IS 21
PG 3
WC Hematology
SC Hematology
GA CA9KQ
UT WOS:000349242702191
ER
PT J
AU Bergmeier, W
Paul, DS
Stefanini, L
Robledo, RF
Chan, ER
Getz, TM
Piatt, R
Boulaftali, Y
Adams, MD
Peters, LL
AF Bergmeier, Wolfgang
Paul, David S.
Stefanini, Lucia
Robledo, Raymond F.
Chan, E. Ricky
Getz, Todd M.
Piatt, Raymond
Boulaftali, Yacine
Adams, Mark D.
Peters, Luanne L.
TI Premature Platelet Activation and Resistance to P2Y12 Inhibitors in
Rasa3 Mutant Mice
SO BLOOD
LA English
DT Meeting Abstract
CT 56th Annual Meeting of the American-Society-of-Hematology
CY DEC 06-09, 2014
CL San Francisco, CA
SP Amer Soc Hematol
C1 [Bergmeier, Wolfgang; Paul, David S.; Stefanini, Lucia; Piatt, Raymond; Boulaftali, Yacine] Univ N Carolina, Chapel Hill, NC USA.
[Robledo, Raymond F.; Peters, Luanne L.] Jackson Lab, Bar Harbor, ME 04609 USA.
[Chan, E. Ricky; Adams, Mark D.] Case Western Reserve Univ, Cleveland, OH 44106 USA.
[Getz, Todd M.] US Army, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC HEMATOLOGY
PI WASHINGTON
PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA
SN 0006-4971
EI 1528-0020
J9 BLOOD
JI Blood
PD DEC 6
PY 2014
VL 124
IS 21
PG 3
WC Hematology
SC Hematology
GA CA9KX
UT WOS:000349243502100
ER
PT J
AU Reddoch, KM
Montgomery, RK
Rodriguez, AC
Meledeo, MA
Pidcoke, HF
Ramasubramanian, AK
Cap, AP
AF Reddoch, Kristin Michelle
Montgomery, Robbie K.
Rodriguez, Armando C.
Meledeo, Michael A.
Pidcoke, Heather F.
Ramasubramanian, Anand K.
Cap, Andrew P.
TI Refrigerated Platelets Are Superior Compared to Standard-of-Care and
Respond to Physiologic Control Mechanisms Under Microfluidic Flow
Conditions
SO BLOOD
LA English
DT Meeting Abstract
CT 56th Annual Meeting of the American-Society-of-Hematology
CY DEC 06-09, 2014
CL San Francisco, CA
SP Amer Soc Hematol
C1 [Reddoch, Kristin Michelle; Ramasubramanian, Anand K.] Univ Texas San Antonio, San Antonio, TX USA.
[Montgomery, Robbie K.; Rodriguez, Armando C.; Meledeo, Michael A.; Pidcoke, Heather F.; Cap, Andrew P.] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX USA.
NR 0
TC 1
Z9 1
U1 0
U2 1
PU AMER SOC HEMATOLOGY
PI WASHINGTON
PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA
SN 0006-4971
EI 1528-0020
J9 BLOOD
JI Blood
PD DEC 6
PY 2014
VL 124
IS 21
PG 3
WC Hematology
SC Hematology
GA CA9HU
UT WOS:000349233806113
ER
PT J
AU Wu, XW
Darlington, DN
Cap, AP
AF Wu, Xiaowu
Darlington, Daniel N.
Cap, Andrew P.
TI Plasminogen and Plasmin Increase after Polytrauma Shifting the
Thrombin/Plasmin Activity Ratio Toward Fibrinolysis
SO BLOOD
LA English
DT Meeting Abstract
CT 56th Annual Meeting of the American-Society-of-Hematology
CY DEC 06-09, 2014
CL San Francisco, CA
SP Amer Soc Hematol
C1 [Wu, Xiaowu; Cap, Andrew P.] JBSA Ft Sam Houston, US Army Inst Surg Res, Houston, TX USA.
[Darlington, Daniel N.] JBSA Ft Sam Houston, Inst Surg Res, Houston, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC HEMATOLOGY
PI WASHINGTON
PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA
SN 0006-4971
EI 1528-0020
J9 BLOOD
JI Blood
PD DEC 6
PY 2014
VL 124
IS 21
PG 3
WC Hematology
SC Hematology
GA CA9HU
UT WOS:000349233801033
ER
PT J
AU Guenon, S
Ramirez, JG
Basaran, AC
Wampler, J
Thiemens, M
Taylor, S
Schuller, IK
AF Guenon, S.
Ramirez, J. G.
Basaran, Ali C.
Wampler, J.
Thiemens, M.
Taylor, S.
Schuller, Ivan K.
TI Search for Superconductivity in Micrometeorites
SO SCIENTIFIC REPORTS
LA English
DT Article
ID TEMPERATURE SUPERCONDUCTIVITY; MICROWAVE-ABSORPTION; VERWEY TRANSITION;
PRESOLAR STARDUST; COSMIC SPHERULES; ACCRETION RATE; MAGNETITE;
METEORITES; FIELD
AB We have developed a very sensitive, highly selective, non-destructive technique for screening inhomogeneous materials for the presence of superconductivity. This technique, based on phase sensitive detection of microwave absorption is capable of detecting 10(-12) cc of a superconductor embedded in a non-superconducting, non-magnetic matrix. For the first time, we apply this technique to the search for superconductivity in extraterrestrial samples. We tested approximately 65 micrometeorites collected from the water well at the Amundsen-Scott South pole station and compared their spectra with those of eight reference materials. None of these micrometeorites contained superconducting compounds, but we saw the Verwey transition of magnetite in our microwave system. This demonstrates that we are able to detect electro-magnetic phase transitions in extraterrestrial materials at cryogenic temperatures.
C1 [Guenon, S.; Ramirez, J. G.; Basaran, Ali C.; Wampler, J.; Schuller, Ivan K.] Univ Calif San Diego, Dept Phys, La Jolla, CA 92093 USA.
[Guenon, S.; Ramirez, J. G.; Basaran, Ali C.; Wampler, J.; Schuller, Ivan K.] Univ Calif San Diego, Ctr Adv Nanosci, La Jolla, CA 92093 USA.
[Guenon, S.] Univ Tubingen, CQ Ctr Collect Quantum Phenomena & Their Applicat, LISA, Inst Phys, D-72076 Tubingen, Germany.
[Thiemens, M.] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA.
[Taylor, S.] Cold Reg Res & Engn Lab, Hanover, NH 03766 USA.
RP Guenon, S (reprint author), Univ Calif San Diego, Dept Phys, La Jolla, CA 92093 USA.
EM stefan.guenon@uni-tuebingen.de
OI Ramirez, Juan Gabriel/0000-0001-8546-6966
FU Deutsche Forschungsgemeinschaft; Open Access Publishing Fund of
Tuebingen University; AFOSR [FA9550-14-1-0202]
FX We thank Dr. Andreas Morlock for pointing out the diversity of
extraterrestrial materials and for the useful discussions at the
beginning of our search for new superconductors. We thank Dr. H.
Weinstock for his original idea on the search for superconductivity in
unconventional materials. The micrometeorites were collected with
support from the National Science Foundation. We acknowledge support by
Deutsche Forschungsgemeinschaft and Open Access Publishing Fund of
Tuebingen University. Research supported by AFOSR grant
FA9550-14-1-0202.
NR 40
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U1 0
U2 26
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD DEC 5
PY 2014
VL 4
AR 7333
DI 10.1038/srep07333
PG 5
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AW4SF
UT WOS:000346270100004
PM 25476841
ER
PT J
AU Kotan, H
Darling, KA
Scattergood, RO
Koch, CC
AF Kotan, Hasan
Darling, Kris A.
Scattergood, Ronald O.
Koch, Carl C.
TI Influence of Zr and nano-Y2O3 additions on thermal stability and
improved hardness in mechanically alloyed Fe base ferritic alloys
SO JOURNAL OF ALLOYS AND COMPOUNDS
LA English
DT Article
DE Nanouystalline materials; Thermal stability; Grain growth; Hardness; ODS
ID NANOCRYSTALLINE MATERIALS; GRAIN-BOUNDARY; DISPERSION; STEEL; GROWTH;
ENERGY; SIZE
AB The motivation of this work was driven to improve the thermal stability in systems where polymorphic transformations can result in an additional driving force, upsetting the expected thermodynamic stability. In this study, Fe92Ni8 alloys with Zr and nano-Y2O3 additions were produced by ball milling and then annealed at high temperatures. Emphasis was placed on understanding the effects of dispersed nano-Y2O3 particle additions and their effect on microstructural stability at and above the bcc-to-fcc transformation occurring at 700 degrees C in Fe-Ni systems. Results reveal that microstructural stability and hardness can be promoted by a combination of Zr and Y2O3 additions, that being mostly effective for stability before and after phase transition, respectively. The mechanical strength of these alloys is achieved by a unique microstructure comprised a ultra-fine grain Fe base matrix, which contains dispersions of both nano-scale in-situ formed Zr base intermetallics and ex-situ added Y2O3 secondary oxide phases. Both of these were found to be essential for a combination of high thermal stability and high mechanical strength properties. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Kotan, Hasan] Necmettin Erbakan Univ, Dept Met Engn & Mat Sci, TR-42140 Meram, Konya, Turkey.
[Darling, Kris A.] US Army Res Lab, Weap & Mat Res Directorate, RDRL WMM F, Aberdeen Proving Ground, MD 21005 USA.
[Scattergood, Ronald O.; Koch, Carl C.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA.
RP Kotan, H (reprint author), Necmettin Erbakan Univ, Dept Met Engn & Mat Sci, Dere Asiklar Mah Demet Sokak, TR-42140 Meram, Konya, Turkey.
EM hkotan@konya.edu.tr
FU NSF-DMR [1005677]; Necmettin Erbakan University
FX The research reported in this paper was supported by NSF-DMR under Grant
No. 1005677 and by Necmettin Erbakan University.
NR 35
TC 4
Z9 4
U1 12
U2 73
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0925-8388
EI 1873-4669
J9 J ALLOY COMPD
JI J. Alloy. Compd.
PD DEC 5
PY 2014
VL 615
BP 1013
EP 1018
DI 10.1016/j.jallcom.2014.07.054
PG 6
WC Chemistry, Physical; Materials Science, Multidisciplinary; Metallurgy &
Metallurgical Engineering
SC Chemistry; Materials Science; Metallurgy & Metallurgical Engineering
GA AP7GL
UT WOS:000342245700157
ER
PT J
AU Stromdahl, E
Hamer, S
Jenkins, S
Sloan, L
Williamson, P
Foster, E
Nadolny, R
Elkins, C
Vince, M
Pritt, B
AF Stromdahl, Ellen
Hamer, Sarah
Jenkins, Sarah
Sloan, Lynne
Williamson, Phillip
Foster, Erik
Nadolny, Robyn
Elkins, Chad
Vince, Mary
Pritt, Bobbi
TI Comparison of phenology and pathogen prevalence, including infection
with the Ehrlichia muris-like (EML) agent, of Ixodes scapularis removed
from soldiers in the midwestern and the northeastern United States over
a 15 year period (1997-2012)
SO PARASITES & VECTORS
LA English
DT Article
DE Climate change; Co-infection; Ehrlichia muris-like agent; Engorgement;
Ixodes scapularis; Pathogen prevalence; Phenology; Surveillance; Tick
population establishment
ID POLYMERASE-CHAIN-REACTION; BORRELIA-BURGDORFERI; LYME-DISEASE;
ANAPLASMA-PHAGOCYTOPHILUM; DEER SURVEILLANCE; BABESIA-MICROTI; TICKS;
WISCONSIN; IXODIDAE; ACARI
AB Background: Since 1997, human-biting ticks submitted to the Department of Defense Human Tick Test Kit Program (HTTKP) of the US Army Public Health Command have been tested for pathogens by PCR. We noted differences in the phenology and infection prevalence among Ixodes scapularis ticks submitted from military installations in different geographic regions. The aim of this study was to characterize these observed differences, comparing the phenology and pathogen infection rates of I. scapularis submitted from soldiers at two sites in the upper Midwest ( Camp Ripley, MN, and Ft. McCoy, WI) and one site in the northeastern US (Ft. Indiantown Gap, PA).
Methods: From 1997 through 2012, the HTTKP received 1,981 I. scapularis from the three installations and tested them for Anaplasma phagocytophilum, Babesia microti, Borrelia burgdorferi and the Ehrlichia muris-like (EML) agent using PCR; pathogen presence was confirmed via sequencing or amplification of a second gene target. Pathogen and co-infection prevalence, tick engorgement status, and phenology were compared among installations.
Results: Greater rates of A. phagocytophilum and Ba. microti infections were detected in ticks submitted from installations in Minnesota than in Wisconsin or Pennsylvania, and the EML agent was only detected in ticks from Minnesota and Wisconsin. Midwestern ticks were also more likely to be co-infected than those from Pennsylvania. Both adult and nymphal ticks showed evidence of feeding on people, although nymphs were more often submitted engorged. Adult I. scapularis were received more frequently in June from Minnesota than from either of the other sites. Minnesota adult and nymphal peaks overlapped in June, and submissions of adults exceeded nymphs in that month.
Conclusions: There were clear differences in I. scapularis phenology, pathogen prevalence and rates of co-infection among the three military installations. Seasonal and temperature differences between the three sites and length of time a population had been established in each region may contribute to the observed differences. The synchrony of adults and nymphs observed in the upper Midwest has implications for pathogen infection prevalence. The EML agent was only detected in Minnesota and Wisconsin, supporting the previous assertion that this pathogen is currently limited to the upper Midwest.
C1 [Stromdahl, Ellen; Foster, Erik; Nadolny, Robyn; Elkins, Chad; Vince, Mary] US Army Publ Hlth Command, Aberdeen Proving Ground, MD 21010 USA.
[Hamer, Sarah] Texas A&M Univ, College Stn, TX USA.
[Jenkins, Sarah; Sloan, Lynne; Pritt, Bobbi] Mayo Clin, Rochester, MN USA.
[Williamson, Phillip] Univ N Texas, Hlth Sci Ctr, Ft Worth, TX USA.
[Williamson, Phillip] Creat Testing Solut, Tempe, AZ USA.
[Foster, Erik] Michigan Dept Community Hlth, Lansing, MI USA.
[Nadolny, Robyn] Old Dominion Univ, Dept Biol Sci, Norfolk, VA 23529 USA.
RP Stromdahl, E (reprint author), US Army Publ Hlth Command, Aberdeen Proving Ground, MD 21010 USA.
EM ellen.y.stromdahl.civ@mail.mil
OI Pritt, Bobbi/0000-0003-0261-1326
NR 38
TC 7
Z9 7
U1 2
U2 76
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1756-3305
J9 PARASITE VECTOR
JI Parasites Vectors
PD DEC 4
PY 2014
VL 7
AR 553
DI 10.1186/s13071-014-0553-z
PG 12
WC Parasitology
SC Parasitology
GA CA5JN
UT WOS:000348944800001
PM 25465046
ER
PT J
AU Stallings, JD
Ippolito, DL
Rakesh, V
Baer, CE
Dennis, WE
Helwig, BG
Jackson, DA
Leon, LR
Lewis, JA
Reifman, J
AF Stallings, Jonathan D.
Ippolito, Danielle L.
Rakesh, Vineet
Baer, Christine E.
Dennis, William E.
Helwig, Bryan G.
Jackson, David A.
Leon, Lisa R.
Lewis, John A.
Reifman, Jaques
TI Patterns of gene expression associated with recovery and injury in
heat-stressed rats
SO BMC GENOMICS
LA English
DT Article
DE Heat stress; Transcriptomics; Proteomics; Systems biology; Protein
aggregation
ID ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE; ACTIVATING
TRANSCRIPTION FACTOR-3; SHOCK PROTEINS; EXTRACELLULAR
HEAT-SHOCK-PROTEIN-72; CROSS-TOLERANCE; MESSENGER-RNA; CELL-SURVIVAL;
AUTOPHAGY; COMPLEX
AB Background: The in vivo gene response associated with hyperthermia is poorly understood. Here, we perform a global, multiorgan characterization of the gene response to heat stress using an in vivo conscious rat model.
Results: We heated rats until implanted thermal probes indicated a maximal core temperature of 41.8 degrees C (T-C,T- Max). We then compared transcriptomic profiles of liver, lung, kidney, and heart tissues harvested from groups of experimental animals at Tc, Max, 24 hours, and 48 hours after heat stress to time-matched controls kept at an ambient temperature. Cardiac histopathology at 48 hours supported persistent cardiac injury in three out of six animals. Microarray analysis identified 78 differentially expressed genes common to all four organs at Tc, Max. Self-organizing maps identified gene-specific signatures corresponding to protein-folding disorders in heat-stressed rats with histopathological evidence of cardiac injury at 48 hours. Quantitative proteomics analysis by iTRAQ (isobaric tag for relative and absolute quantitation) demonstrated that differential protein expression most closely matched the transcriptomic profile in heat-injured animals at 48 hours. Calculation of protein supersaturation scores supported an increased propensity of proteins to aggregate for proteins that were found to be changing in abundance at 24 hours and in animals with cardiac injury at 48 hours, suggesting a mechanistic association between protein misfolding and the heat-stress response.
Conclusions: Pathway analyses at both the transcript and protein levels supported catastrophic deficits in energetics and cellular metabolism and activation of the unfolded protein response in heat-stressed rats with histopathological evidence of persistent heat injury, providing the basis for a systems-level physiological model of heat illness and recovery.
C1 [Stallings, Jonathan D.; Dennis, William E.; Leon, Lisa R.] US Army Ctr Environm Hlth Res, Environm Hlth Program, Ft Detrick, MD 21702 USA.
[Ippolito, Danielle L.] Oak Ridge Inst Sci & Educ, Ft Detrick, MD USA.
[Rakesh, Vineet; Reifman, Jaques] US Army Med Res & Mat Command, DoD Biotechnol High Performance Comp Software App, Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA.
[Baer, Christine E.] Excet Inc, Ft Detrick, MD USA.
[Helwig, Bryan G.; Leon, Lisa R.] US Army Res Inst Environm Med, Thermal Mt Med Div, Natick, MA USA.
[Jackson, David A.] US Army Ctr Environm Hlth Res, Pulm Hlth Program, Ft Detrick, MD 21702 USA.
RP Stallings, JD (reprint author), US Army Ctr Environm Hlth Res, Environm Hlth Program, Bldg 568 Doughten Dr, Ft Detrick, MD 21702 USA.
EM jonathan.d.stallings.mil@mail.mil
OI Stallings, Jonathan/0000-0002-6430-5888
FU Research Participation Program at the US Army Center for Environmental
Health Research; Military Operational Medicine Research Program, US Army
Medical Research and Materiel Command, Fort Detrick, Maryland; U.S.
Department of Energy; MRMC; USACEHR
FX We would like to thank Dr. Roy Vigneulle (Military Operational Medicine
Research Program), CAPT Carroll D. Forcino (Director, Military
Operational Medicine Research Program), COL Richard P. Duncan (former
Commander, USACEHR), and COL Thomas C. Timmes (current Commander,
USACEHR) for their programmatic support, encouragement, and insightful
discussion. We also thank J. Ward, S. Dineen, M. Blaha, and R. Duran for
technical support with the rat heat-stress experiments. We thank Gian G.
Tartaglia and Michele Vendruscolo (University of Cambridge and
Northwestern University) for batch calculation of the zagg
and zaggSC used to calculate the sigmaf
scores reported in this paper. This research was supported in part by an
appointment to the Research Participation Program at the US Army Center
for Environmental Health Research administered by the Oak Ridge
Institute for Science and Education through an interagency agreement
between the U.S. Department of Energy and MRMC and USACEHR. The research
was supported by the Military Operational Medicine Research Program, US
Army Medical Research and Materiel Command, Fort Detrick, Maryland.
NR 95
TC 8
Z9 9
U1 1
U2 11
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2164
J9 BMC GENOMICS
JI BMC Genomics
PD DEC 3
PY 2014
VL 15
AR 1058
DI 10.1186/1471-2164-15-1058
PG 19
WC Biotechnology & Applied Microbiology; Genetics & Heredity
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA AW6OF
UT WOS:000346388000001
PM 25471284
ER
PT J
AU Lambeth, RH
Baranoski, MH
AF Lambeth, Robert H.
Baranoski, Myvan H.
TI Oxidative Stabilization of Poly(norbornene) Polymers Prepared by Ring
Opening Metathesis Polymerization
SO JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY
LA English
DT Article
DE stabilization; oxidation induction temperature; hindered phenol; ROMP
ID THERMAL-OXIDATION; ABILITY; ROMP
AB Polymers prepared by ring opening methathesis polymerization contain double bonds along the backbone and are susceptible to oxidation during high temperature processing or device operation. To overcome this, we report a simple method to improve the oxidative stability of ROMP based polymers by inclusion of a small percentage of monomer functionalized with a radical scavenger in the feedstock. The oxidation induction temperature was improved from 111 degrees C up to 262 degrees C when 8mol% of the functionalized comonomer was included in the feedstock. Modest improvements in the thermal decomposition temperature were also observed.
C1 [Lambeth, Robert H.; Baranoski, Myvan H.] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
RP Lambeth, RH (reprint author), US Army, Res Lab, Weap & Mat Res Directorate, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA.
EM robert.h.lambeth2.civ@mail.mil
NR 20
TC 1
Z9 1
U1 2
U2 19
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1060-1325
EI 1520-5738
J9 J MACROMOL SCI A
JI J. Macromol. Sci. Part A-Pure Appl. Chem.
PD DEC 2
PY 2014
VL 51
IS 12
BP 962
EP 965
DI 10.1080/10601325.2014.967085
PG 4
WC Polymer Science
SC Polymer Science
GA AT3WH
UT WOS:000344863400003
ER
PT J
AU Lundy, JB
AF Lundy, Jonathan B.
TI A Primer on Wound Healing in Colorectal Surgery in the Age of
Bioprosthetic Materials
SO CLINICS IN COLON AND RECTAL SURGERY
LA English
DT Article
DE wound healing; gastrointestinal; anastomosis; bioprosthetic mesh
ID ACELLULAR DERMAL MATRIX; KERATINOCYTE GROWTH-FACTOR; VENTRAL HERNIA
REPAIR; CROHNS-DISEASE; EXTRACELLULAR-MATRIX; PREOPERATIVE IRRADIATION;
INTESTINAL ANASTOMOSES; COLONIC ANASTOMOSES; REDUCED EXPRESSION;
COLLAGEN-SYNTHESIS
AB Wound healing is a complex, dynamic process that is vital for closure of cutaneous injuries, restoration of abdominal wall integrity after laparotomy closure, and to prevent anastomotic dehiscence after bowel surgery. Derangements in healing have been described in multiple processes including diabetes mellitus, corticosteroid use, irradiation for malignancy, and inflammatory bowel disease. A thorough understanding of the process of healing is necessary for clinical decision making and knowledge of the current state of the science may lead future researchers in developing methods to enable our ability to modulate healing, ultimately improving outcomes. An exciting example of this ability is the use of bioprosthetic materials used for abdominal wall surgery (hernia repair/reconstruction). These bioprosthetic meshes are able to regenerate and remodel from an allograft or xenograft collagen matrix into site-specific tissue; ultimately being degraded and minimizing the risk of long-term complications seen with synthetic materials. The purpose of this article is to review healing as it relates to cutaneous and intestinal trauma and surgery, factors that impact wound healing, and wound healing as it pertains to bioprosthetic materials.
C1 US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
RP Lundy, JB (reprint author), US Army, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.
EM Jonathan.b.lundy2.mil@mail.mil
NR 103
TC 1
Z9 1
U1 0
U2 0
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 1531-0043
EI 1530-9681
J9 CLIN COLON RECT SURG
JI Clin. Colon Rectal Surg.
PD DEC
PY 2014
VL 27
IS 4
BP 125
EP 133
DI 10.1055/s-0034-1394086
PG 9
WC Gastroenterology & Hepatology; Surgery
SC Gastroenterology & Hepatology; Surgery
GA CL3XH
UT WOS:000356884800003
PM 25435821
ER
PT J
AU Brooker, MJW
AF Brooker, Major John W.
TI IMPROVING UNIFORM CODE OF MILITARY JUSTICE REFORM
SO MILITARY LAW REVIEW
LA English
DT Article
C1 US Army, Washington, DC 20310 USA.
RP Brooker, MJW (reprint author), US Army, Washington, DC 20310 USA.
NR 237
TC 0
Z9 0
U1 3
U2 3
PU JUDGE ADVOCATE GENERALS SCHOOL
PI CHARLOTTESVILLE
PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA
SN 0026-4040
J9 MIL LAW REV
JI Milit. Law Rev.
PD WIN
PY 2014
VL 222
BP 1
EP 128
PG 128
WC Law
SC Government & Law
GA CI2ON
UT WOS:000354587000001
ER
PT J
AU Babb, MNH
AF Babb, Major Nathaniel H.
TI DON'T FORGET THE FAR EAST: A MODERN LESSON FROM THE CHINESE PROSECUTION
OF JAPANESE WAR CRIMINALS AFTER WORLD WAR II
SO MILITARY LAW REVIEW
LA English
DT Article
ID JUSTICE
C1 US Army, Washington, DC 20310 USA.
RP Babb, MNH (reprint author), US Army, Washington, DC 20310 USA.
NR 70
TC 0
Z9 0
U1 1
U2 1
PU JUDGE ADVOCATE GENERALS SCHOOL
PI CHARLOTTESVILLE
PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA
SN 0026-4040
J9 MIL LAW REV
JI Milit. Law Rev.
PD WIN
PY 2014
VL 222
BP 129
EP 155
PG 27
WC Law
SC Government & Law
GA CI2ON
UT WOS:000354587000002
ER
PT J
AU Hamaguchi, MCAM
AF Hamaguchi, Major Cara-Ann M.
TI A PRECARIOUS BALANCE: MANAGING STIGMA, CONFIDENTIALITY, AND COMMAND
AWARENESS IN THE MENTAL HEALTH ARENA
SO MILITARY LAW REVIEW
LA English
DT Article
C1 US Army, Washington, DC 20310 USA.
RP Hamaguchi, MCAM (reprint author), US Army, Washington, DC 20310 USA.
NR 77
TC 0
Z9 0
U1 1
U2 2
PU JUDGE ADVOCATE GENERALS SCHOOL
PI CHARLOTTESVILLE
PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA
SN 0026-4040
J9 MIL LAW REV
JI Milit. Law Rev.
PD WIN
PY 2014
VL 222
BP 156
EP 210
PG 55
WC Law
SC Government & Law
GA CI2ON
UT WOS:000354587000003
ER
PT J
AU Valente, JJ
LeGrande, CL
Johnson, VM
Fischer, RA
AF Valente, Jonathon J.
LeGrande, Christa L.
Johnson, Vincent M.
Fischer, Richard A.
TI A Method for Improving the Reliability of Sound Broadcast Systems Used
in Ecological Research and Management
SO WILDLIFE SOCIETY BULLETIN
LA English
DT Article
DE bird song; CD player; momentary action pushbutton switch; play button
depression mechanism; sound broadcast system
ID BREEDING HABITAT SELECTION; GAP-CROSSING DECISIONS; TEMPERATE
RAIN-FOREST; CONSPECIFIC-ATTRACTION; DETECTION PROBABILITY; SITE
SELECTION; SOCIAL INFORMATION; UNDERSTORY BIRDS; SONGBIRDS; CALLS
AB Automated sound broadcast systems have been used to address a variety of ecological questions, and show great potential as a management tool. Such systems need to be reliable because treatments are often applied in the absence of a human observer and system failure can cause methodological ambiguity. During the breeding seasons of 2012 and 2013, we used a sound broadcast system previously described by Farrell and Campomizzi (2011) in an experiment evaluating the use of post-breeding song in forest-bird habitat selection in southern Indiana, USA. This system incorporates a portable compact disc (CD) player where the play button is permanently depressed using manual compression so that when a timer connects an electrical current to the unit, the CD player automatically starts. Despite exhaustive efforts to find a reliable way to manually compress the play button on numerous CD player models, play button failure was the most significant source of broadcast system failure (88%) in 2012. We attempted to resolve this problem in 2013 by removing the need for manual compression and soldering the play button contact poles on each CD players' integrated circuit boards. Though we did experience broadcast system failures during < 5% of treatment periods in 2013, none of those were attributable to play button failure. By removing all possibility of failure from manual play button compression we improved our system reliability. Thus, soldering theCD player play button on such broadcast systems represents a methodological improvement that can be used by researchers and managers interested in sound broadcast. (C) 2014 The Wildlife Society.
C1 [Valente, Jonathon J.] Oregon State Univ, Dept Forest Ecosyst & Soc, Corvallis, OR 97331 USA.
[LeGrande, Christa L.] SUNY Coll Environm Sci & Forestry, Dept Environm & Forest Biol, Syracuse, NY 13210 USA.
[Johnson, Vincent M.] SUNY Agr & Tech Coll Cobleskill, Fisheries Wildlife & Environm Studies Dept, Cobleskill, NY 12043 USA.
[Fischer, Richard A.] US Army, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
RP Valente, JJ (reprint author), Oregon State Univ, Dept Forest Ecosyst & Soc, Corvallis, OR 97331 USA.
EM jonathon.j.valente@gmail.com
NR 28
TC 0
Z9 0
U1 0
U2 6
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1938-5463
J9 WILDLIFE SOC B
JI Wildl. Soc. Bull.
PD DEC
PY 2014
VL 38
IS 4
BP 827
EP 830
DI 10.1002/wsb.468
PG 4
WC Biodiversity Conservation
SC Biodiversity & Conservation
GA CD9RA
UT WOS:000351434500022
ER
PT J
AU Stone, JK
DeShazer, D
Brett, PJ
Burtnick, MN
AF Stone, Joshua K.
DeShazer, David
Brett, Paul J.
Burtnick, Mary N.
TI Melioidosis: molecular aspects of pathogenesis
SO EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
LA English
DT Review
DE Burkholderia pseudomallei; capsule; facultative intracellular pathogen;
lipopolysaccharide; melioidosis; pathogenesis; secretion systems;
virulence factors
ID III SECRETION SYSTEM; ACTIN-BASED MOTILITY; BURKHOLDERIA-PSEUDOMALLEI
LIPOPOLYSACCHARIDE; INFECTED MOUSE MACROPHAGES; INTRACELLULAR
LIFE-CYCLE; REGULATORY PROTEIN ALPHA; MOTIF-CONTAINING PROTEIN;
QUORUM-SENSING SYSTEM; GIANT-CELL FORMATION; IN-VIVO VIRULENCE
AB Burkholderia pseudomallei is a gram-negative bacterium that causes melioidosis, a multifaceted disease that is highly endemic in southeast Asia and northern Australia. This facultative intracellular pathogen possesses a large genome that encodes a wide array of virulence factors that promote survival in vivo by manipulating host cell processes and disarming elements of the host immune system. Antigens and systems that play key roles in B. pseudomallei virulence include capsular polysaccharide, lipopolysaccharide, adhesins, specialized secretion systems, actin-based motility and various secreted factors. This review provides an overview of the current and steadily expanding knowledge regarding the molecular mechanisms used by this organism to survive within a host and their contribution to the pathogenesis of melioidosis.
C1 [Stone, Joshua K.; Brett, Paul J.; Burtnick, Mary N.] Univ S Alabama, Dept Microbiol & Immunol, Mobile, AL 36688 USA.
[DeShazer, David] US Army, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA.
RP Burtnick, MN (reprint author), Univ S Alabama, Dept Microbiol & Immunol, 610 Clin Dr, Mobile, AL 36688 USA.
EM mburtnick@southalabama.edu
FU NIH-National Institute of Allergy and Infectious Diseases; DOD-Defense
Threat Reduction Agency; NIH-NIAID [AI065359, AIO91783]
FX The authors are funded by the NIH-National Institute of Allergy and
Infectious Diseases and DOD-Defense Threat Reduction Agency. MN Burtnick
and PJ Brett declare NIH-NIAID award numbers AI065359 and AIO91783. D
Deshazer declares DTRA/JSTO-CBD proposal number CBCALL12-LSI-2-0070. The
authors have no other relevant affiliations or financial involvement
with any organization or entity with a financial interest in or
financial conflict with the subject matter or materials discussed in the
manuscript apart from those disclosed.
NR 123
TC 7
Z9 7
U1 5
U2 23
PU EXPERT REVIEWS
PI LONDON
PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB,
ENGLAND
SN 1478-7210
EI 1744-8336
J9 EXPERT REV ANTI-INFE
JI Expert Rev. Anti-Infect. Ther.
PD DEC
PY 2014
VL 12
IS 12
BP 1487
EP 1499
DI 10.1586/14787210.2014.970634
PG 13
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA CB6XV
UT WOS:000349771200007
PM 25312349
ER
PT J
AU Lynn, DC
Lesemann, RK
Detro, JF
Seery, JM
AF Lynn, David C.
Lesemann, Rebecca K.
Detro, John F.
Seery, Jason M.
TI Employment of the "Role 2-Plus": Lessons Learned in a Time of High
OPTEMPO
SO MILITARY MEDICINE
LA English
DT Editorial Material
AB From 2009 to 2014, the medical units at Fort Bragg, North Carolina, gained extensive experience in the nondoctrinal employment of the Forward Surgical Team (FST) combined with an Area Support Medical Company (ASMC) or Brigade Support Medical Company (BSMC). The setup and execution of the so-called "Role 2-plus" offers multiple operational and clinical advantages over solitary employment, but also presents some significant logistical challenges without proper planning. At the time of authorship, current literature describes this entity, (1) but information or guidance as to the actual employment of the Role 2-plus (including web-based outlets such as Center for Army Lessons Learned) is almost nonexistent. (1-6) Former commanders of these units would like to share and document some of the lessons learned during a time of exceptionally high operational tempo (OPTEMPO).
C1 [Lynn, David C.] Womack Army Med Ctr, Dept Surg, Ft Bragg, NC 28310 USA.
[Lesemann, Rebecca K.] Texas A&M Univ, Bush Sch Govt & Publ Serv, College Stn, TX 77843 USA.
[Detro, John F.] USDA, XVIII Airborne Corps, Off Corps Surg, Ft Bragg, NC 28310 USA.
[Seery, Jason M.] Jackson Mem Hosp, US Army Trauma Training Ctr, Ryder Trauma Ctr, Miami, FL 33136 USA.
RP Lynn, DC (reprint author), Womack Army Med Ctr, Dept Surg, 2817 Reilly Rd, Ft Bragg, NC 28310 USA.
NR 16
TC 0
Z9 0
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD DEC
PY 2014
VL 179
IS 12
BP 1412
EP 1418
DI 10.7205/MILMED-D-14-00099
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA CA7MB
UT WOS:000349100300003
PM 25469961
ER
PT J
AU Bornemann, P
Bornemann, G
AF Bornemann, Paul
Bornemann, Gina
TI Military Family Physicians' Perceptions of a Pocket Point-of-Care
Ultrasound Device in Clinical Practice
SO MILITARY MEDICINE
LA English
DT Article
AB Point-of-care ultrasonography with a pocket ultrasound device, General Electric Medical Systems Vscan (Milwaukee, Wisconsin), has been shown to be effective and easy to learn. However, no studies to date have evaluated its use in the military primary care setting where its portability and value in bedside diagnosis would be especially beneficial. We tested the feasibility of the Vscan in the day-to-day care of patients by family physicians in their clinic, inpatient wards, and its potential for use in the military-deployed setting. Participants were trained and credentialed in the use of the point-of-care ultrasonography. Then, participants were provided with a pocket ultrasound device to use in their normal day-to-day practice. Additionally, participants completed surveys and provided ratings on their perceptions regarding the use of the device. According to the survey analysis, participants found the devices to be easy to use, valuable in discerning a diagnosis, and were not prohibitively time consuming. Moreover, patients were perceived by the participants to have been satisfied with the use of the device. Overall, participants had high satisfaction with the Vscan and perceived that the device would be highly valuable in the military-deployed setting.
C1 [Bornemann, Paul; Bornemann, Gina] Tripler Army Med Ctr, Dept Family Med, Honolulu, HI 96859 USA.
RP Bornemann, P (reprint author), Tripler Army Med Ctr, Dept Family Med, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
FU Department of Family Medicine at Tripler Army Medical Center; U.S. Army
Medical Research and Material Command, Fort Detrick, MD (DHP 6.7 Grant)
[20013008]
FX We thank the Department of Family Medicine at Tripler Army Medical
Center for supporting this study. We thank Dr. Matt Dawson, Dr. Mike
Mallin of The Ultrasound Podcast, and Dr. Will Scruggs for providing the
initial 16-hour training session. Financial support was received by the
U.S. Army Medical Research and Material Command, Fort Detrick, MD (DHP
6.7 Grant Number 20013008).
NR 5
TC 3
Z9 3
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD DEC
PY 2014
VL 179
IS 12
BP 1474
EP 1477
DI 10.7205/MILMED-D-14-00241
PG 4
WC Medicine, General & Internal
SC General & Internal Medicine
GA CA7MB
UT WOS:000349100300013
PM 25469971
ER
PT J
AU Sulsky, SI
Karlsson, LH
Bulzacchelli, MT
Luippold, RS
Rodriguez-Monguio, R
Bulathsinhala, L
Hill, OT
AF Sulsky, Sandra I.
Karlsson, Lee H.
Bulzacchelli, Maria T.
Luippold, Rose S.
Rodriguez-Monguio, Rosa
Bulathsinhala, Lakmini
Hill, Owen T.
TI Methodological Challenges of Using US Army Administrative Data to
Identify a Cohort of Basic Combat Trainees and Descriptive Analysis of
Trends in Characteristics That Are Potential Risk Factors for
Training-Related Injury
SO MILITARY MEDICINE
LA English
DT Article
ID YOUNG MEN; MILITARY; PREVENTION; OVERWEIGHT; OBESITY; STRESS; RATES;
WOMEN
AB Objectives: Training-related injury is a threat to military health and readiness. Prevalence of potential risk factors for training-related injury can change with U. S. Army recruitment goals and may influence basic combat training (BCT) injury rates. This article describes challenges of using administrative data to identify a trainee cohort and describes demographic and training characteristics across the five BCT locations. Methods: Data from the Total Army Injury and Health Outcomes Database were used to identify a U. S. Army-wide cohort of first-time trainees from January 1, 2002 to September 30, 2007 and describe its characteristics. Results: The cohort includes 368,102 first-time trainees. The annual number starting BCT increased from 52,187 in 2002 to 68,808 in 2004. The proportion of males increased from 81.57% in 2003 to 83.84% in 2007. Mean (SD) age increased from 20.67 (3.55) years in 2002 to 20.94 (3.65) years in 2007. Mean (SD) body mass index increased from 24.53 (3.56) kg/m(2) in 2002 to 24.94 (3.84) kg/m(2) in 2006. Other characteristics fluctuated by year, including proportions of race/ethnicity, accession waivers, and confirmed graduates. Conclusions: Fluctuations in trainee characteristics warrant further analysis of potential influence on BCT injury rates. For research uses, careful acquisition of administrative data is needed.
C1 [Sulsky, Sandra I.; Karlsson, Lee H.; Luippold, Rose S.] ENVIRON Int Corp, Amherst, MA 01002 USA.
[Bulzacchelli, Maria T.; Rodriguez-Monguio, Rosa] Univ Massachusetts, Dept Publ Hlth, Amherst, MA 01002 USA.
[Bulathsinhala, Lakmini; Hill, Owen T.] US Army Res Inst Environm Med, Mil Performance Div, Natick, MA 01760 USA.
RP Sulsky, SI (reprint author), ENVIRON Int Corp, 28 Amity St,Suite 2A, Amherst, MA 01002 USA.
FU U.S. Army Medical Research Materiel Command [W911QY-10-C-0194]; U.S.
Army Research Institute of Environmental Medicine
FX The authors thank the data providers, as well as DMDC data expert Mr.
Richard Moreno for assistance interpreting relationships among dates and
variables in the various data sources and Dr. Colleen Barkley for
supplying ATRRS data to verify the annual number of BCT recruits at Fort
Jackson, SC. We also thank Ms. Cynthia Lemire for assistance preparing
the manuscript. This work was supported by the U.S. Army Medical
Research Materiel Command under contract no. W911QY-10-C-0194 in
collaboration with the U.S. Army Research Institute of Environmental
Medicine.
NR 19
TC 1
Z9 1
U1 0
U2 2
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD DEC
PY 2014
VL 179
IS 12
BP 1487
EP 1496
DI 10.7205/MILMED-D-14-00007
PG 10
WC Medicine, General & Internal
SC General & Internal Medicine
GA CA7MB
UT WOS:000349100300015
PM 25469973
ER
PT J
AU Cutter, L
Clarke, T
AF Cutter, Laura
Clarke, Tim, Jr.
TI Anesthesia Advances During the Civil War
SO MILITARY MEDICINE
LA English
DT Editorial Material
C1 [Cutter, Laura; Clarke, Tim, Jr.] US Army Med Res & Mat Command, Natl Museum Hlth & Med, Silver Spring, MD 20910 USA.
RP Cutter, L (reprint author), US Army Med Res & Mat Command, Natl Museum Hlth & Med, 2500 Linden Lane, Silver Spring, MD 20910 USA.
NR 0
TC 1
Z9 1
U1 0
U2 1
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD DEC
PY 2014
VL 179
IS 12
BP 1503
EP 1503
DI 10.7205/MILMED-D-14-00344
PG 1
WC Medicine, General & Internal
SC General & Internal Medicine
GA CA7MB
UT WOS:000349100300017
PM 25469975
ER
PT J
AU Teyhen, DS
Aldag, M
Centola, D
Edinborough, E
Ghannadian, JD
Haught, A
Jackson, T
Kinn, J
Kunkler, KJ
Levine, B
Martindale, VE
Neal, D
Snyder, LB
Styn, MA
Thorndike, F
Trabosh, V
Parramore, DJ
AF Teyhen, Deydre S.
Aldag, Matt
Centola, Damon
Edinborough, Elton
Ghannadian, Jason D.
Haught, Andrea
Jackson, Theresa
Kinn, Julie
Kunkler, Kevin J.
Levine, Betty
Martindale, Valerie E.
Neal, David
Snyder, Leslie B.
Styn, Mindi A.
Thorndike, Frances
Trabosh, Valerie
Parramore, David J.
TI Incentives to Create and Sustain Healthy Behaviors: Technology Solutions
and Research Needs
SO MILITARY MEDICINE
LA English
DT Editorial Material
ID SELF-DETERMINATION THEORY; RANDOMIZED CONTROLLED-TRIAL;
PHYSICAL-ACTIVITY INTERVENTION; WEIGHT-LOSS MAINTENANCE; MASS-MEDIA
CAMPAIGNS; SOCIAL MEDIA; INTRINSIC MOTIVATION; INTERNET INTERVENTIONS;
COLLECTIVE DYNAMICS; EXTRINSIC REWARDS
AB Health-related technology, its relevance, and its availability are rapidly evolving. Technology offers great potential to minimize and/or mitigate barriers associated with achieving optimal health, performance, and readiness. In support of the U.S. Army Surgeon General's vision for a "System for Health" and its Performance Triad initiative, the U.S. Army Telemedicine and Advanced Technology Research Center hosted a workshop in April 2013 titled "Incentives to Create and Sustain Change for Health." Members of government and academia participated to identify and define the opportunities, gain clarity in leading practices and research gaps, and articulate the characteristics of future technology solutions to create and sustain real change in the health of individuals, the Army, and the nation. The key factors discussed included (1) public health messaging, (2) changing health habits and the environmental influence on health, (3) goal setting and tracking, (4) the role of incentives in behavior change intervention, and (5) the role of peer and social networks in change. This report summarizes the recommendations on how technology solutions could be employed to leverage evidence-based best practices and identifies gaps in research where further investigation is needed.
C1 [Teyhen, Deydre S.; Edinborough, Elton; Ghannadian, Jason D.; Haught, Andrea; Kunkler, Kevin J.; Levine, Betty; Trabosh, Valerie] US Army Med Res & Mat Command, Ft Detrick, MD 21702 USA.
[Aldag, Matt] Booz Allen Hamilton, Rockville, MD 20852 USA.
[Centola, Damon] Univ Penn, Annenberg Sch, Network Sci Inst, Philadelphia, PA 19104 USA.
[Jackson, Theresa] Army Inst Publ Hlth, Aberdeen Proving Ground, MD 21010 USA.
[Kinn, Julie] Joint Base Lewis McChord, Natl Ctr Telehlth & Technol, Washington, DC 20431 USA.
[Martindale, Valerie E.] Booz Allen Hamilton, Dayton, OH 45420 USA.
[Neal, David] Empirica Res, Miami, FL 33133 USA.
[Snyder, Leslie B.] Univ Connecticut, Ctr Hlth Intervent & Prevent, Dept Commun, Storrs, CT 06269 USA.
[Styn, Mindi A.] Univ Pittsburgh, Sch Nursing, Dept Hlth & Community Syst, Pittsburgh, PA 15261 USA.
[Styn, Mindi A.] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15261 USA.
[Thorndike, Frances] Univ Virginia Hlth Syst, Dept Psychiat & Neurobehav Sci, Charlottesville, VA 22908 USA.
[Parramore, David J.] Off Surg Gen, Falls Church, VA 22042 USA.
RP Teyhen, DS (reprint author), US Army Med Res & Mat Command, Ft Detrick, MD 21702 USA.
NR 124
TC 1
Z9 1
U1 2
U2 16
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD DEC
PY 2014
VL 179
IS 12
BP 1419
EP 1431
DI 10.7205/MILMED-D-14-00111
PG 13
WC Medicine, General & Internal
SC General & Internal Medicine
GA CA7MB
UT WOS:000349100300004
PM 25469962
ER
PT J
AU Williams, RM
Ray, LE
Lever, JH
Burzynski, AM
AF Williams, Rebecca M.
Ray, Laura E.
Lever, James H.
Burzynski, Amy M.
TI Crevasse Detection in Ice Sheets Using Ground Penetrating Radar and
Machine Learning
SO IEEE JOURNAL OF SELECTED TOPICS IN APPLIED EARTH OBSERVATIONS AND REMOTE
SENSING
LA English
DT Article
DE Geophysical signal processing; ground penetrating radar (GPR); robotic
sensing systems
ID HIDDEN MARKOV-MODELS; LANDMINE DETECTION; SPEECH RECOGNITION; GPR;
IMAGES
AB This paper presents methods to automatically classify ground penetrating radar (GPR) images of crevasses on ice sheets. We use a combination of support vector machines (SVMs) and hidden Markov models (HMMs) with down sampling, a preprocessing step that is unbiased and suitable for real-time analysis and detection. We perform modified cross-validation experiments with 129 examples of Greenland GPR imagery from 2012, collected by a lightweight robot towing a GPR. In order to minimize false positives, an HMM classifier is trained to prescreen the data and mark locations in the GPR files to evaluate with an SVM, and we evaluate the classification results with a similar modified cross-validation technique. The combined HMM-SVM method retains all of the correct classifications by the SVM, and reduces the false positive rate to 0.0007. This method also reduces the computational burden in classifying GPR traces because the SVM is evaluated only on select prescreened traces. Our experiments demonstrate the promise, robustness, and reliability of real-time crevasse detection and classification with robotic GPR surveys.
C1 [Williams, Rebecca M.] Dartmouth Coll, Hanover, NH 03755 USA.
[Ray, Laura E.] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA.
[Lever, James H.; Burzynski, Amy M.] US Army Cold Reg Res & Engn Lab, Hanover, NH 03755 USA.
RP Williams, RM (reprint author), Johns Hopkins Univ, Appl Phys Lab, Johns Hopkins Rd, Laurel, MD 20723 USA.
EM rebecca.williams@jhuapl.edu; lray@dartmouth.edu;
james.lever@erdc.dren.mil; amy.burzynski@unco.edu
FU National Science Foundation [NSF-ART0806157, NSF-DGE0801490]
FX This work was supported by the National Science Foundation under Grant
NSF-ART0806157 and Grant NSF-DGE0801490.
NR 27
TC 1
Z9 1
U1 3
U2 10
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1939-1404
EI 2151-1535
J9 IEEE J-STARS
JI IEEE J. Sel. Top. Appl. Earth Observ. Remote Sens.
PD DEC
PY 2014
VL 7
IS 12
SI SI
BP 4836
EP 4848
DI 10.1109/JSTARS.2014.2332872
PG 13
WC Engineering, Electrical & Electronic; Geography, Physical; Remote
Sensing; Imaging Science & Photographic Technology
SC Engineering; Physical Geography; Remote Sensing; Imaging Science &
Photographic Technology
GA AZ7BA
UT WOS:000348372000020
ER
PT J
AU Trope, RL
Hantover, LL
AF Trope, Roland L.
Hantover, Lixian Loong
TI In the Wake of Cyber Damage: Significant Decisions in Cybersecurity
2013-2014
SO BUSINESS LAWYER
LA English
DT Article
C1 [Trope, Roland L.] New York City Off Trope & Schramm LLP, New York, NY 10017 USA.
[Trope, Roland L.] US Mil Acad, Dept Law, West Point, NY USA.
[Hantover, Lixian Loong] Wilson Sonsini Goodrich & Rosati, Palo Alto Off, Palo Alto, CA USA.
RP Trope, RL (reprint author), New York City Off Trope & Schramm LLP, New York, NY 10017 USA.
EM rltrope@tropelaw.com; lhantover@wsgr.com
NR 5
TC 1
Z9 1
U1 0
U2 6
PU AMER BAR ASSOC, ADMINISTRATIVE LAW & REGULATORY PRACTICE SECTION
PI CHICAGO
PA 321 N CLARK ST, CHICAGO, IL 60610 USA
SN 0007-6899
EI 2164-1838
J9 BUS LAWYER
JI Bus. Lawyer
PD WIN
PY 2014
VL 70
IS 1
BP 223
EP 230
PG 8
WC Law
SC Government & Law
GA AZ5KT
UT WOS:000348260700009
ER
PT J
AU Newman, T
Farrell, SL
Richter-Menge, J
Connor, LN
Kurtz, NT
Elder, BC
McAdoo, D
AF Newman, Thomas
Farrell, Sinead L.
Richter-Menge, Jacqueline
Connor, Laurence N.
Kurtz, Nathan T.
Elder, Bruce C.
McAdoo, David
TI Assessment of radar-derived snow depth over Arctic sea ice
SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS
LA English
DT Article
DE snow; sea ice; remote sensing; instruments and techniques; wavelet
transform
ID THICKNESS; MISSION; LASER
AB Knowledge of contemporaneous snow depth on Arctic sea ice is important both to constrain the regional climatology and to improve the accuracy of satellite altimeter estimates of sea ice thickness. We assess new data available from the NASA Operation IceBridge snow radar instrument and derive snow depth estimates across the western Arctic ice pack using a novel methodology based on wavelet techniques that define the primary reflecting surfaces within the snow pack. We assign uncertainty to the snow depth estimates based upon both the radar system parameters and sea ice topographic variability. The accuracy of the airborne snow depth estimates are examined via comparison with coincident measurements gathered in situ across a range of ice types in the Beaufort Sea. We discuss the effect of surface morphology on the derivation, and consequently the accuracy, of airborne snow depth estimates. We find that snow depths derived from the airborne snow radar using the wavelet-based technique are accurate to 1 cm over level ice. Over rougher surfaces including multiyear and ridged ice, the radar system is impacted by ice surface morphology. Across basin scales, we find the snow-radar-derived snow depth on first-year ice is at least approximate to 60% of the value reported in the snow climatology for the Beaufort Sea, Canada Basin, and parts of the central Arctic, since these regions were previously dominated by multiyear ice during the measurement period of the climatology. Snow on multiyear ice is more consistent with the climatology.
C1 [Newman, Thomas; Farrell, Sinead L.; McAdoo, David] Univ Maryland, Earth Syst Sci Interdisciplinary Ctr, College Pk, MD 20742 USA.
[Newman, Thomas; Farrell, Sinead L.; Connor, Laurence N.; McAdoo, David] NOAA, Lab Satellite Altimetry, Satellite Oceanog & Climatol Div, Ctr Weather & Climate Predict, College Pk, MD USA.
[Richter-Menge, Jacqueline; Elder, Bruce C.] US Army Corps Engn, Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH USA.
[Kurtz, Nathan T.] NASA, Goddard Space Flight Ctr, Hydrospher & Biospher Sci Lab, Greenbelt, MD 20771 USA.
RP Newman, T (reprint author), Univ Maryland, Earth Syst Sci Interdisciplinary Ctr, College Pk, MD 20742 USA.
EM tnewman3@umd.edu
RI Connor, Laurence/E-7930-2011; McAdoo, Dave/F-5612-2010; Farrell,
Sinead/F-5586-2010
OI Connor, Laurence/0000-0002-5276-6257; McAdoo, Dave/0000-0002-7533-5564;
Farrell, Sinead/0000-0003-3222-2751
FU ONR Arctic grants [N000141210512, N0001412MP20150]; NOAA Ocean Remote
Sensing Program
FX Data used for the results of this paper are found at the National Snow
and Ice Data Center (NSIDC, nsidc.org). IceBridge data utilized in this
study are archived at the NSIDC: the IceBridge ATM Level-1B Elevation
and Return Strength (ILATM1B) data set is available at
http://nsidc.org/data/ilatm1b.html, the DMS L1B Geolocated and
Orthorectified Images (IODMS1B) data set is available at
http://nsidc.org/data/iodms1b.html, the NASA IceBridge Snow Radar
Level-1B Geolocated Radar Echo Strength Profiles (IRSNO1B) data set is
available at http://nsidc.org/data/irsno1b.html, and the IceBridge Sea
Ice Freeboard, Snow Depth, and Thickness (IDCSI2) data set is available
at http://nsidc.org/data/idcsi2.html. This work was supported by ONR
Arctic grants N000141210512 and N0001412MP20150 and by the NOAA Ocean
Remote Sensing Program. The authors thank Dr. L. Miller and two
anonymous reviewers for their comments which helped to improve the text.
The authors thank the IceBridge Instrument Teams, Science Team, and
Project Science Office, as well as the aircraft support crew, for their
diligent efforts in gathering and processing the OIB data. We
acknowledge the significant work done by the CReSIS faculty, staff, and
students in the design, development, operation, and data processing for
the snow radar system. The authors thank the U.S. Army Cold Regions
Research and Engineering Laboratory for collecting the in situ data. The
authors thank the Naval Research Laboratory for their logistical
support, including members of the field team. The authors thank the
Arctic Submarine Laboratory for providing the ice camp that served as
the base of operations for the in situ observation team and assisted in
the coordination of the aircraft over flights. Data used in this paper
were acquired by NASAs Operation IceBridge Project. The contents are
solely the opinions of the authors and do not constitute a statement of
policy, decision, or position on behalf of NOAA or the U.S. Government.
NR 41
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U1 3
U2 17
PU AMER GEOPHYSICAL UNION
PI WASHINGTON
PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA
SN 2169-9275
EI 2169-9291
J9 J GEOPHYS RES-OCEANS
JI J. Geophys. Res.-Oceans
PD DEC
PY 2014
VL 119
IS 12
BP 8578
EP 8602
DI 10.1002/2014JC010284
PG 25
WC Oceanography
SC Oceanography
GA AZ8GI
UT WOS:000348452800022
ER
PT J
AU Perovich, DK
Jones, KF
AF Perovich, Donald K.
Jones, Kathleen F.
TI The seasonal evolution of sea ice floe size distribution
SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS
LA English
DT Article
DE sea ice; floe size distribution; floe breaking
ID ARCTIC-OCEAN; SUMMER; COVER; SHEBA
AB The Arctic sea ice cover undergoes large changes over an annual cycle. In winter and spring, the ice cover consists of large, snow-covered plate-like ice floes, with very little open water. By the end of summer, the snow cover is gone and the large floes have broken into a complex mosaic of smaller, rounded floes surrounded by a lace of open water. This evolution strongly affects the distribution and fate of the solar radiation deposited in the ice-ocean system and consequently the heat budget of the ice cover. In particular, increased floe perimeter can result in enhanced lateral melting. We attempt to quantify the floe evolution process through the concept of a floe size distribution that is modified by lateral melting and floe breaking. A time series of aerial photographic surveys made during the SHEBA field experiment is analyzed to determine evolution of the floe size distribution from spring through summer. Based on earlier studies, we assume the floe size cumulative distribution could be represented by a power law D-, where D is the floe diameter. The exponent as well as the number density of floes N-tot are estimated from measurements of total ice area and perimeter. As summer progressed, there was an increase in as the size distribution shifted toward smaller floes and the number of floes increased. Lateral melting causes the distribution to deviate from a power law for small floe sizes.
C1 [Perovich, Donald K.; Jones, Kathleen F.] ERDC CRREL, Hanover, NH 03755 USA.
[Perovich, Donald K.] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA.
RP Perovich, DK (reprint author), ERDC CRREL, Hanover, NH 03755 USA.
EM Donald.k.perovich@usace.army.mil
FU Office of Naval Research; CRREL Microgrant program
FX This work was funded by the Office of Naval Research and the CRREL
Microgrant program. We thank the Editor, Andrey Proshutinsky, and three
anonymous reviewers for their valuable insights and suggestions. The
data and images used in this paper are available from the lead author.
NR 20
TC 7
Z9 8
U1 2
U2 7
PU AMER GEOPHYSICAL UNION
PI WASHINGTON
PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA
SN 2169-9275
EI 2169-9291
J9 J GEOPHYS RES-OCEANS
JI J. Geophys. Res.-Oceans
PD DEC
PY 2014
VL 119
IS 12
BP 8767
EP 8777
DI 10.1002/2014JC010136
PG 11
WC Oceanography
SC Oceanography
GA AZ8GI
UT WOS:000348452800031
ER
PT J
AU Freese, EC
Acitelli, RM
Gist, NH
Cureton, KJ
Evans, EM
O'Connor, PJ
AF Freese, Eric C.
Acitelli, Rachelle M.
Gist, Nicholas H.
Cureton, Kirk J.
Evans, Ellen M.
O'Connor, Patrick J.
TI Effect of Six Weeks of Sprint Interval Training on Mood and Perceived
Health in Women at Risk for Metabolic Syndrome
SO JOURNAL OF SPORT & EXERCISE PSYCHOLOGY
LA English
DT Article
DE exercise psychology; exercise training; health behavior
ID QUALITY-OF-LIFE; POSTPRANDIAL LIPEMIA; PHYSICAL-ACTIVITY; EXERCISE;
ADAPTATIONS; SYMPTOMS; CAPACITY; MUSCLE; PERFORMANCE; DEPRESSION
AB The purpose of this investigation was to determine whether 6 weeks of sprint interval training (SIT) is associated with changes in mood and perceived health in women at risk for developing metabolic syndrome (MetS). Physically inactive women (30-65 years) were randomized to 6 weeks of nutrition meetings and SIT (n = 23; 3 bouts/week of 4-8 30-s cycle sprints with 4-mM recovery) or a nonexercise control condition (CON; n = 24). Before and after the 6-week intervention, perceived health status and mood were assessed. Clinically relevant increases in role-physical scores (ES = 0.64) and vitality (ES = 0.52) were found after 6 weeks of SIT compared with a nonexercise control group. For middle-aged women at risk for MetS, it is concluded that high-intensity, low-volume SIT (1) increases feelings of vitality and perceptions of having fewer physical limitations and (2) does not induce mood disturbances as occurs with high-volume, high-intensity training.
C1 [Freese, Eric C.; Acitelli, Rachelle M.; Gist, Nicholas H.; Cureton, Kirk J.; Evans, Ellen M.; O'Connor, Patrick J.] Univ Georgia, Dept Kinesiol, Athens, GA 30602 USA.
[Gist, Nicholas H.] US Mil Acad, Dept Phys Educ, West Point, NY 10996 USA.
RP Freese, EC (reprint author), Univ Georgia, Dept Kinesiol, Athens, GA 30602 USA.
EM efreese2@gmail.com
FU Egg Nutrition Center
FX The authors thank Jeremy Dean, Sasha McBurse, and Chad Straight for
their assistance with the exercise training and Catherine Beck and
Whitni McConnell for their weight maintenance and dietary guidance. In
addition, the authors thank the undergraduate research assistants in the
Department of Kinesiology, especially Sara Dover and Rachel Butler, for
their assistance with testing, data entry, and supervising exercise
training sessions. This randomized clinical trial was supported by the
Egg Nutrition Center. The authors declare no conflicts of interest.
NR 31
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Z9 4
U1 2
U2 13
PU HUMAN KINETICS PUBL INC
PI CHAMPAIGN
PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA
SN 0895-2779
EI 1543-2904
J9 J SPORT EXERCISE PSY
JI J. Sport Exerc. Psychol.
PD DEC
PY 2014
VL 36
IS 6
BP 610
EP 618
DI 10.1123/jsep.2014-0083
PG 9
WC Hospitality, Leisure, Sport & Tourism; Psychology, Applied; Psychology;
Sport Sciences
SC Social Sciences - Other Topics; Psychology; Sport Sciences
GA AZ8UY
UT WOS:000348491000006
PM 25602143
ER
PT J
AU Enslen, JA
AF Enslen, Joshua Alma
TI Between Tijuca and Mars Maddening Intertextualities in Clarice
Lispector's "A imitacao da rosa"
SO LUSO-BRAZILIAN REVIEW
LA English
DT Article
C1 US Mil Acad, West Point, NY USA.
RP Enslen, JA (reprint author), US Mil Acad, West Point, NY USA.
NR 11
TC 0
Z9 0
U1 0
U2 1
PU UNIV WISCONSIN PRESS
PI MADISON
PA JOURNAL DIVISION, 1930 MONROE ST, 3RD FL, MADISON, WI 53711 USA
SN 0024-7413
EI 1548-9957
J9 LUSO-BRAZ REV
JI Luso-Braz. Rev.
PD DEC 1
PY 2014
VL 51
IS 2
BP 68
EP 79
PG 12
WC Humanities, Multidisciplinary
SC Arts & Humanities - Other Topics
GA AZ4OK
UT WOS:000348201700004
ER
PT J
AU Esposito, ER
Wilken, JM
AF Esposito, Elizabeth Russell
Wilken, Jason M.
TI Biomechanical risk factors for knee osteoarthritis when using passive
and powered ankle-foot prostheses
SO CLINICAL BIOMECHANICS
LA English
DT Article
DE Loading; Gait; Transtibial; Amputation; BiOM
ID TRANS-TIBIAL AMPUTATION; LOWER-LIMB AMPUTEES; FRONTAL PLANE; GAIT;
WALKING; JOINT; HIP; MOMENTS; LOAD; LEG
AB Background: Gait compensations following transtibial amputation negatively affect sound limb loading and increase the risk of knee osteoarthritis. Push-off assistance provided by new powered prostheses may decrease the demands on the sound limb. However, their effects in a young population in the early stages of prosthetic use are still unknown. The purpose of this study was to compare limb loading between 1. passive and powered ankle-foot prostheses, 2. sound and amputated limbs, and 3. individuals with amputations in the relatively early stages of prosthetic use and controls. Methods: Ten young, active individuals with unilateral transtibial amputation and 10 controls underwent biomechanical gait analysis at three speeds. The peak external knee flexor and adductor moments, adductor moment's angular impulse, peak vertical ground reaction force and loading rate were calculated. Repeated measures ANOVAs compared between limbs, prostheses, and groups. Findings: The powered prosthesis did not decrease the sound limb's peak adduction moment or its impulse, but did decrease the external flexor moment, peak vertical force and loading rate as speed increased. The powered prosthesis decreased the loading rate from controls. The sound limb did not display a significantly greater risk for knee osteoarthritis than the intact limb or than controls in either device. Interpretation: In the early stages of prosthetic use, young individuals with transtibial amputation display few biomechanical risk factors for knee osteoarthritis development. However, a powered ankle-foot prosthesis still offers some benefits and may be used prophylactically to mitigate potential increases of these variables with continued prosthetic use over time.
C1 Brooke Army Med Ctr, Ctr Intrepid, Ft Sam Houston, TX 78234 USA.
RP Esposito, ER (reprint author), Ctr Intrepid, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM erussell.kin@gmail.com
OI Wilken, Jason/0000-0002-5556-7667
FU Center for Rehabilitation Sciences Research (CRSR); Department of
Physical Medicine and Rehabilitation; Uniformed Services University of
Health Sciences, Bethesda, MD; U.S. Army Telemedicine & Advanced
Technology Research Center (TATRC) [W81K00-09-P-1129]
FX Support provided by the Center for Rehabilitation Sciences Research
(CRSR), Department of Physical Medicine and Rehabilitation, Uniformed
Services University of Health Sciences, Bethesda, MD and U.S. Army
Telemedicine & Advanced Technology Research Center (TATRC)
(W81K00-09-P-1129).
NR 56
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Z9 7
U1 4
U2 18
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0268-0033
EI 1879-1271
J9 CLIN BIOMECH
JI Clin. Biomech.
PD DEC
PY 2014
VL 29
IS 10
BP 1186
EP 1192
PG 7
WC Engineering, Biomedical; Orthopedics; Sport Sciences
SC Engineering; Orthopedics; Sport Sciences
GA AY5CW
UT WOS:000347591800016
ER
PT J
AU Koppenhaver, SL
Hebert, JJ
Kawchuk, GN
Childs, JD
Teyhen, DS
Croy, T
Fritz, JM
AF Koppenhaver, Shane L.
Hebert, Jeffrey J.
Kawchuk, Greg N.
Childs, John D.
Teyhen, Deydre S.
Croy, Theodore
Fritz, Julie M.
TI Criterion validity of manual assessment of spinal stiffness
SO MANUAL THERAPY
LA English
DT Article
DE Stiffness; Low back pain; Validity; Manual assessment
ID LOW-BACK-PAIN; RANDOMIZED CONTROLLED-TRIAL; CLINICAL-PREDICTION RULE;
LUMBAR SPINE; INTERVERTEBRAL MOTION; SEGMENTAL MOBILITY; NECK PAIN;
RELIABILITY; PALPATION; MANIPULATION
AB Assessment of spinal stiffness is widely used by manual therapy practitioners as a part of clinical diagnosis and treatment selection. Although studies have commonly found poor reliability of such procedures, conflicting evidence suggests that assessment of spinal stiffness may help predict response to specific treatments. The current study evaluated the criterion validity of manual assessments of spinal stiffness by comparing them to indentation measurements in patients with low back pain (LBP). As part of a standard examination, an experienced clinician assessed passive accessory spinal stiffness of the L3 vertebrae using posterior to anterior (PA) force on the spinous process of L3 in 50 subjects (54% female, mean (SD) age = 33.0 (12.8) years, BMI = 27.0 (6.0) kg/m(2)) with LBP. A criterion measure of spinal stiffness was performed using mechanized indentation by a blinded second examiner. Results indicated that manual assessments were uncorrelated to criterion measures of stiffness (spearman rho = 0.06, p = 0.67). Similarly, sensitivity and specificity estimates of judgments of hypomobility were low (0.20-0.45) and likelihood ratios were generally not statistically significant. Sensitivity and specificity of judgments of hypermobility were not calculated due to limited prevalence. Additional analysis found that BMI explained 32% of the variance in the criterion measure of stiffness, yet failed to improve the relationship between assessments. Additional studies should investigate whether manual assessment of stiffness relates to other clinical and biomechanical constructs, such as symptom reproduction, angular rotation, quality of motion, or end feel. Published by Elsevier Ltd.
C1 [Koppenhaver, Shane L.; Teyhen, Deydre S.; Croy, Theodore] Baylor Univ, US Army, Doctoral Program Phys Therapy, San Antonio, TX USA.
[Fritz, Julie M.] Univ Utah, Coll Hlth, Salt Lake City, UT USA.
[Fritz, Julie M.] Intermt Hlth Care, Salt Lake City, UT USA.
[Hebert, Jeffrey J.] Murdoch Univ, Sch Psychol & Exercise Sci, Perth, WA, Australia.
[Kawchuk, Greg N.] Univ Alberta, Dept Phys Therapy, Edmonton, AB T6G 2M7, Canada.
[Childs, John D.] Keesler Air Force Base, Dept Phys Therapy MSGS SGCUY, Med Grp 81st, Biloxi, MS USA.
RP Koppenhaver, SL (reprint author), 204 Tuttle Rd, San Antonio, TX USA.
EM shanekoppenhaver@mac.com
OI Croy, Theodore/0000-0002-3053-8974; Hebert, Jeffrey/0000-0002-6959-325X
FU National Institutes of Health, National Center for Complementary and
Alternative Medicine [R21 AT004221]
FX This study was supported by the National Institutes of Health, National
Center for Complementary and Alternative Medicine (R21 AT004221). This
study was approved by the Institutional Review Boards of the University
of Utah. The opinions or assertions contained herein are the private
views of the authors and are not to be construed as official or as
reflecting the views of the Departments of the Army or Defense.
NR 36
TC 2
Z9 2
U1 1
U2 5
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 1356-689X
EI 1532-2769
J9 MANUAL THER
JI Man. Ther.
PD DEC
PY 2014
VL 19
IS 6
BP 589
EP 594
DI 10.1016/j.math.2014.06.001
PG 6
WC Rehabilitation
SC Rehabilitation
GA AY7DH
UT WOS:000347721000013
PM 24965495
ER
PT J
AU Baker, MD
Simkins, S
Spokas, LA
Veneman, PLM
Xing, BS
AF Baker, M. D.
Simkins, S.
Spokas, L. A.
Veneman, P. L. M.
Xing, B. S.
TI Comparison of Phosphorus Sorption by Light-Weight Aggregates Produced in
the United States
SO PEDOSPHERE
LA English
DT Article
DE binding affinity; constructed wetlands; equilibrium P concentration;
media; P sorption capacity
ID POTENTIAL FILTER MEDIA; CONSTRUCTED WETLANDS; ETHANOL-PRODUCTION;
REMOVAL; WATER
AB In this study, phosphorus (P) sorption of thirteen light-weight aggregates (LWAs) from USA was compared during batch equilibrium experiments in order to identify those materials which had the highest P sorption capacity for further study. Seven different levels of sorption activity were observed, which were broadly grouped into three categories high performing, middle performing, and low performing aggregates. Chemical analysis of Ca, Al, Fe, and Mg was used to describe the differences between LWAs. There was a significant correlation between cation (especially Al, Ca, Fe, and Mg) content and P sorbed. Langmuir isotherms were used to describe P sorption maximum and binding affinity for four of the top five performing LWAs, Universal, Stalite "D", Stalite "Mix", and TXI. The fifth aggregate, Lehigh, exhibited more complex sorption, and was better described by the Freundlich isotherm. Universal had a mean P sorption at the highest concentration of 824 mg kg(-1), well above its calculated sorption maximum (702 mg kg(-1)), and also had the highest binding affinity (1.1 L mg(-1)). This experiment suggests that the top performing LWA (Universal) may perform poorly in column and field studies due to observed precipitates, which could degrade constructed wetland performance. Other LWAs may exhibit superior field performance due to their high calculated sorption maxima. In general, these results highlight the importance of batch experiments as a first step in identifying materials suitable for column and field experiments.
C1 [Baker, M. D.; Simkins, S.; Spokas, L. A.; Veneman, P. L. M.; Xing, B. S.] Univ Massachusetts, Stockbridge Sch Agr, Amherst, MA 01003 USA.
[Baker, M. D.] US Army, Ft Hood, TX 76544 USA.
RP Spokas, LA (reprint author), Univ Massachusetts, Stockbridge Sch Agr, Amherst, MA 01003 USA.
EM mspokas@psis.umass.edu
FU Soil Characterization Laboratory, University of Masachusetts, Amherst,
MA, USA
FX Supported by the Soil Characterization Laboratory, University of
Masachusetts, Amherst, MA, USA.
NR 23
TC 0
Z9 0
U1 2
U2 7
PU SCIENCE PRESS
PI BEIJING
PA 16 DONGHUANGCHENGGEN NORTH ST, BEIJING 100717, PEOPLES R CHINA
SN 1002-0160
EI 2210-5107
J9 PEDOSPHERE
JI Pedosphere
PD DEC
PY 2014
VL 24
IS 6
BP 808
EP 816
PG 9
WC Soil Science
SC Agriculture
GA AY7XN
UT WOS:000347769300012
ER
PT J
AU Willens, S
Cox, DM
Braue, EH
Myers, TM
Wegner, MD
AF Willens, Scott
Cox, David M.
Braue, Ernest H.
Myers, Todd M.
Wegner, Matthew D.
TI Novel Technique for Retroperitoneal Implantation of Telemetry
Transmitters for Physiologic Monitoring in Gottingen Minipigs (Sus
scrofa domesticus)
SO COMPARATIVE MEDICINE
LA English
DT Article
ID NERVE AGENT VX; PERCUTANEOUS-ABSORPTION; RHESUS MACAQUES; ECG LEAD;
SKIN; MODEL; PIG; PLACEMENT; TOXICITY; EXPOSURE
AB Telemetric monitoring of physiologic parameters in animal models is a critical component of chemical and biologic agent studies. The long-term collection of neurobehavioral and other physiologic data can require larger telemetry devices. Furthermore, such devices must be implanted in a location that is safe, well-tolerated, and functional. Gottingen minipigs (Sus scrota domesticus) present an ideal large animal model for chemical agent studies due to their relatively small size, characterized health status, and ease of training and handling. We report an effective approach to implanting a novel device to measure transthoracic impedance to approximate respiratory tidal volume and rate in Suidae. We tested the approach using 24 male Gottingen minipigs. A ventral midline abdominal incision extending from the umbilicus to the prepuce was followed by a paramedian incision of the parietal peritoneum and dorsal blunt dissection to create a retroperitoneal pocket. The device was anchored inside the pocket to the internal abdominal musculature with 3-0 nonabsorbable suture, biopotential leads were routed through the abdominal musculature, and the pocket was closed with 3-0 absorbable suture. Paired biopotential leads were anchored intermuscularly at the level of the seventh rib midway between spine and sternum bilaterally to provide surrogate data for respiratory function. Postoperative recovery and gross pathology findings at necropsy were used to assess safety and refine the surgical procedure. Results demonstrated that this procedure permitted effective monitoring of complex physiologic data, including transthoracic impedance, without negatively affecting the health and behavior of the animals.
C1 [Willens, Scott; Braue, Ernest H.; Myers, Todd M.] US Army, Med Res Inst Chem Def, Analyt Toxicol Div, Aberdeen Proving Ground, MD 21010 USA.
[Wegner, Matthew D.] US Army, Med Res Inst Chem Def, Res Support Div, Aberdeen Proving Ground, MD 21010 USA.
[Cox, David M.] Walter Reed Army Inst Res, Vet Serv Program, Silver Spring, MD USA.
RP Willens, S (reprint author), US Army, Med Res Inst Chem Def, Analyt Toxicol Div, Aberdeen Proving Ground, MD 21010 USA.
EM scott.willensanil@mail.mil
FU Defense Threat Reduction Agency-Joint Science and Technology Office,
Medical ST Division
FX We acknowledge the surgical expertise and assistance of LTC Chad D
Foster, Dipl ACLAM, and MAJ Eric D Lee, as well as the surgical and
telemetry training provided by Megan Swaab Fine, MS. Photographs were
taken by Ms Stephanie R Froberg. This research was supported by the
Defense Threat Reduction Agency-Joint Science and Technology Office,
Medical S&T Division. The views expressed in this report are those of
the authors and do not reflect the official policy of the Department of
Army, Department of Defense, or the US Government.
NR 36
TC 1
Z9 1
U1 0
U2 3
PU AMER ASSOC LABORATORY ANIMAL SCIENCE
PI MEMPHIS
PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA
SN 1532-0820
J9 COMPARATIVE MED
JI Comparative Med.
PD DEC
PY 2014
VL 64
IS 6
BP 464
EP 470
PG 7
WC Veterinary Sciences; Zoology
SC Veterinary Sciences; Zoology
GA AX4IE
UT WOS:000346895800006
PM 25527027
ER
PT J
AU Garrison, AR
Giomarelli, BG
Lear-Rooney, CM
Saucedo, CJ
Yellayi, S
Krumpe, LRH
Rose, M
Paragas, J
Bray, M
Olinger, GG
McMahon, JB
Huggins, J
O'Keefe, BR
AF Garrison, Aura R.
Giomarelli, Barbara G.
Lear-Rooney, Calli M.
Saucedo, Carrie J.
Yellayi, Srikanth
Krumpe, Lauren R. H.
Rose, Maura
Paragas, Jason
Bray, Mike
Olinger, Gene G., Jr.
McMahon, James B.
Huggins, John
O'Keefe, Barry R.
TI The cyanobacterial lectin scytovirin displays potent in vitro and in
vivo activity against Zaire Ebola virus
SO ANTIVIRAL RESEARCH
LA English
DT Article
DE Ebola; Scytovirin; Lectin; Natural product; Cyanobacteria
ID ANTI-HIV PROTEIN; CYANOVIRIN-N; INACTIVATING PROTEIN; FILOVIRUS
INFECTION; SCYTONEMA-VARIUM; GLYCOPROTEIN; ENTRY; GRIFFITHSIN;
INHIBITOR; BINDS
AB The cyanobacterial lectin scytovirin (SVN) binds with high affinity to mannose-rich oligosaccharides on the envelope glycoprotein (GP) of a number of viruses, blocking entry into target cells. In this study, we assessed the ability of SVN to bind to the envelope GP of Zaire Ebola virus (ZEBOV) and inhibit its replication. SVN interacted specifically with the protein's mucin-rich domain. In cell culture, it inhibited ZEBOV replication with a 50% virus-inhibitory concentration (EC50) of 50 nM, and was also active against the Angola strain of the related Marburg virus (MARV), with a similar EC50. Injected subcutaneously in mice, SVN reached a peak plasma level of 100 nm in 45 min, but was cleared within 4 h. When ZEBOV-infected mice were given 30 mg/kg/day of SVN by subcutaneous injection every 6 h, beginning the day before virus challenge, 9 of 10 animals survived the infection, while all infected, untreated mice died. When treatment was begun one hour or one day after challenge, 70-90% of mice survived. Quantitation of infectious virus and viral RNA in samples of serum, liver and spleen collected on days 2 and 5 postinfection showed a trend toward lower titers in treated than control mice, with a significant decrease in liver titers on day 2. Our findings provide further evidence of the potential of natural lectins as therapeutic agents for viral infections. Published by Elsevier B.V.
C1 [Garrison, Aura R.; Lear-Rooney, Calli M.; Paragas, Jason; Bray, Mike; Olinger, Gene G., Jr.; Huggins, John] US Army, Med Res Inst Infect Dis, Dept Viral Therapeut, Div Virol, Ft Detrick, MD 21702 USA.
[Giomarelli, Barbara G.; Saucedo, Carrie J.; Krumpe, Lauren R. H.; Rose, Maura; McMahon, James B.; O'Keefe, Barry R.] NCI, Ctr Canc Res, Mol Targets Lab, NIH,Frederick Natl Lab Canc Res, Ft Detrick, MD 21702 USA.
[Saucedo, Carrie J.; Krumpe, Lauren R. H.] Leidos Biomed Res Inc, Frederick Natl Lab Canc Res, Basic Sci Program, Frederick, MD 21702 USA.
[Yellayi, Srikanth] NIAID, Off Chief Scientist, Integrated Res Facil, Div Clin Res, Frederick, MD USA.
[Bray, Mike] NIAID, Div Clin Res, NIH, Bethesda, MD 20892 USA.
RP O'Keefe, BR (reprint author), NCI, Mol Targets Lab, Bldg 562,Rm 201, Ft Detrick, MD 21702 USA.
EM okeefeba@mail.nih.gov
FU Intramural Research Program of the NIH, National Cancer Institute,
Center for Cancer Research and the NIAID Trans-NIH/FDA Biodefense Grant
Program; Frederick National Laboratory for Cancer Research, National
Institutes of Health [HHSN261200800001E]
FX This research was supported by the Intramural Research Program of the
NIH, National Cancer Institute, Center for Cancer Research and the NIAID
Trans-NIH/FDA Biodefense Grant Program. This project has been funded in
whole or in part with federal funds from the Frederick National
Laboratory for Cancer Research, National Institutes of Health, under
contract HHSN261200800001E. The content of this publication does not
necessarily reflect the views or policies of the Department of Health
and Human Services, nor does mention of trade names, commercial
products, or organizations imply endorsement by the U.S. Government.
Opinions, interpretations, conclusions, and recommendations are those of
the author and are not necessarily endorsed by the U.S. Army.
NR 24
TC 11
Z9 13
U1 3
U2 26
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-3542
EI 1872-9096
J9 ANTIVIR RES
JI Antiviral Res.
PD DEC
PY 2014
VL 112
BP 1
EP 7
DI 10.1016/j.antiviral.2014.09.012
PG 7
WC Pharmacology & Pharmacy; Virology
SC Pharmacology & Pharmacy; Virology
GA AX5CE
UT WOS:000346943900001
PM 25265598
ER
PT J
AU Shekh-Ahmad, T
Mawasi, H
McDonough, JH
Finnell, RH
Wlodarczyk, BJ
Yavin, E
Bialer, M
AF Shekh-Ahmad, Tawfeeq
Mawasi, Hafiz
McDonough, John H.
Finnell, Richard H.
Wlodarczyk, Bogdan J.
Yavin, Eylon
Bialer, Meir
TI Enantioselective pharmacodynamic and pharmacokinetic analysis of two
chiral CNS-active carbamate derivatives of valproic acid
SO EPILEPSIA
LA English
DT Article
DE New antiepileptic drugs; Valproic acid; Carbamates derivatives of VPA;
CNS drugs; Enantioselective pharmacokinetic; Pharmacodynamic analysis
ID SOMAN-INDUCED SEIZURES; ANTIEPILEPTIC DRUGS; STATUS EPILEPTICUS;
ANTICONVULSANT ACTIVITY; UNIQUE ACTIVITY; EPILEPSY; DISCOVERY;
2ND-GENERATION; CARBAMAZEPINE; VALNOCTAMIDE
AB Objective2-Ethyl-3-methylbutyl-carbamate (EMC) and 2-isopropylpentyl-carbamate (IPC) are among the most potent anticonvulsant carbamate derivatives of valproic acid. EMC and IPC are chiral compounds. Consequently, the aim of the current study was to comparatively evaluate the pharmacokinetic (PK) and pharmacodynamic (PD anticonvulsant activity) profile of EMC and IPC individual enantiomers.
MethodsThe anticonvulsant activity of EMC and IPC individual enantiomers was evaluated in several anticonvulsant rodent models including maximal electroshock (MES), 6Hz psychomotor, subcutaneous (pentylenetetrazole) (scMet), and the pilocarpine-induced and soman-induced status epilepticus (SE). The PK-PD relationship of EMC and IPC individual enantiomers was evaluated following intraperitoneal administration (50mg/kg) to rats. Induction of neural tube defects (NTDs) was evaluated in a mouse strain that was highly susceptible to teratogen-induced NTDs.
ResultsIn mice and rats, (2S)-EMC exhibited anticonvulsant activity similar to that of racemic EMC in the MES and scMet tests, whereas in the 6Hz test, racemic EMC was more potent than its two individual enantiomers. Racemic EMC exhibited a potent activity in the soman-induced SE model when administered 5 and 20min after seizure onset with median effective dose (ED50) values of 33 and 48mg/kg, respectively. (2R)-IPC and (2S)-IPC exhibited ED50 values similar to those of racemic IPC in the mouse and rat MES and scMet models. (2R)-IPC had similar ED50 values on the 6Hz tests. Racemic IPC had an ED50 value of 107mg/kg in the pilocarpine-induced SE model when given 30min after seizure onset. Racemic EMC and IPC and their enantiomers had similar clearance (3.8-5.5L/h/kg) and short half-life (<1h). EMC and its enantiomers did not cause NTDs at doses 3-10 times higher than their anticonvulsant ED50 values.
SignificanceEMC and IPC did not exhibit enantioselective PK, a fact that may contribute to their nonenantioselective activity in any of the anticonvulsant models. The nonsignificant difference between racemic EMC and racemic IPC and their enantiomers, suggests that their wide spectrum of anticonvulsant activity is likely to be caused by multiple mechanisms of action.
C1 [Shekh-Ahmad, Tawfeeq; Mawasi, Hafiz; Yavin, Eylon; Bialer, Meir] Hebrew Univ Jerusalem, Sch Pharm, Inst Drug Res, Fac Med, IL-91120 Jerusalem, Israel.
[McDonough, John H.] US Army Med Res Inst Chem Def, Pharmacol Branch, Div Res, Aberdeen Proving Ground, MD USA.
[Finnell, Richard H.; Wlodarczyk, Bogdan J.] Univ Texas Austin, Dell Pediat Res Inst, Dept Nutr Sci, Austin, TX 78712 USA.
[Bialer, Meir] Hebrew Univ Jerusalem, David R Bloom Ctr Pharm, IL-91120 Jerusalem, Israel.
RP Bialer, M (reprint author), Hebrew Univ Jerusalem, Sch Pharm, Inst Drug Res, Fac Med, POB 12065, IL-91120 Jerusalem, Israel.
EM bialer@md.huji.ac.il
OI Wlodarczyk, Bogdan J./0000-0001-5249-5832
FU Bial; CTS Chemicals; Desitin; Janssen-Cilag; Johnson Johnson; Medgenics;
Rekah; Sepracor; Teva; UCB Pharma; Upsher-Smith
FX Dr. Meir Bialer has received in the last 3 years speakers or consultancy
fees from Bial, CTS Chemicals, Desitin, Janssen-Cilag, Johnson &
Johnson, Medgenics, Rekah, Sepracor, Teva, UCB Pharma, and Upsher-Smith.
Dr. Bialer has been involved in the design and development of new
antiepileptics and CNS drugs as well as new formulations of existing
drugs. None of the other authors has any conflict of interest to
disclose. We, the authors, confirm that we have read the Journal's
position on issues involved in ethical publication and affirm that this
report is consistent with those guidelines.
NR 39
TC 1
Z9 1
U1 1
U2 8
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0013-9580
EI 1528-1167
J9 EPILEPSIA
JI Epilepsia
PD DEC
PY 2014
VL 55
IS 12
BP 1944
EP 1952
DI 10.1111/epi.12857
PG 9
WC Clinical Neurology
SC Neurosciences & Neurology
GA AX5OE
UT WOS:000346975200014
PM 25442425
ER
PT J
AU Dankova, V
Balonova, L
Straskova, A
Spidlova, P
Putzova, D
Kijek, T
Bozue, J
Cote, C
Mou, S
Worsham, P
Szotakova, B
Cerveny, L
Stulik, J
AF Dankova, Vera
Balonova, Lucie
Straskova, Adela
Spidlova, Petra
Putzova, Daniela
Kijek, Todd
Bozue, Joel
Cote, Christopher
Mou, Sherry
Worsham, Patricia
Szotakova, Barbora
Cerveny, Lukas
Stulik, Jiri
TI Characterization of Tetratricopeptide Repeat-Like Proteins in
Francisella tularensis and Identification of a Novel Locus Required for
Virulence
SO INFECTION AND IMMUNITY
LA English
DT Article
ID LIVE VACCINE STRAIN; ESCHERICHIA-COLI; SIGNAL-TRANSDUCTION;
MEMBRANE-PROTEINS; TULAREMIA; MACROPHAGES; SYSTEM; GENES; REPLICATION;
MODULATION
AB Francisella tularensis is a highly infectious bacterium that causes the potentially lethal disease tularemia. This extremely virulent bacterium is able to replicate in the cytosolic compartments of infected macrophages. To invade macrophages and to cope with their intracellular environment, Francisella requires multiple virulence factors, which are still being identified. Proteins containing tetratricopeptide repeat (TPR)-like domains seem to be promising targets to investigate, since these proteins have been reported to be directly involved in virulence-associated functions of bacterial pathogens. Here, we studied the role of the FTS_0201, FTS_0778, and FTS_1680 genes, which encode putative TPR-like proteins in Francisella tularensis subsp. holarctica FSC200. Mutants defective in protein expression were prepared by TargeTron insertion mutagenesis. We found that the locus FTS_1680 and its ortholog FTT_0166c in the highly virulent Francisella tularensis type A strain SchuS4 are required for proper intracellular replication, full virulence in mice, and heat stress tolerance. Additionally, the FTS_1680-encoded protein was identified as a membrane-associated protein required for full cytopathogenicity in macrophages. Our study thus identifies FTS_1680/FTT_0166c as a new virulence factor in Francisella tularensis.
C1 [Dankova, Vera; Szotakova, Barbora] Charles Univ Prague, Fac Pharm Hradec Kralove, Dept Biochem Sci, Hradec Kralove, Czech Republic.
[Dankova, Vera; Balonova, Lucie; Straskova, Adela; Spidlova, Petra; Putzova, Daniela; Stulik, Jiri] Univ Def, Fac Mil Hlth Sci, Inst Mol Pathol, Hradec Kralove, Czech Republic.
[Kijek, Todd; Bozue, Joel; Cote, Christopher; Mou, Sherry; Worsham, Patricia] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
[Cerveny, Lukas] Charles Univ Prague, Fac Pharm Hradec Kralove, Dept Pharmacol & Toxicol, Hradec Kralove, Czech Republic.
RP Cerveny, L (reprint author), Charles Univ Prague, Fac Pharm Hradec Kralove, Dept Pharmacol & Toxicol, Hradec Kralove, Czech Republic.
EM cervenyl@faf.cuni.cz
FU Grant Agency of Charles University, Prague, Czech Republic
[160/50/15011, SVV260065, D-CZ-10-00001, CB3387 PA D-CZ-11-0001]
FX This work was supported by grants 160/50/15011 from the Grant Agency of
Charles University, Prague, Czech Republic (SVV260065, DTRA project
D-CZ-10-00001, and DTRA project CB3387 PA D-CZ-11-0001).
NR 47
TC 1
Z9 1
U1 2
U2 6
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0019-9567
EI 1098-5522
J9 INFECT IMMUN
JI Infect. Immun.
PD DEC
PY 2014
VL 82
IS 12
BP 5035
EP 5048
DI 10.1128/IAI.01620-14
PG 14
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA AX5HZ
UT WOS:000346958400014
PM 25245806
ER
PT J
AU Jelacic, TM
Chabot, DJ
Bozue, JA
Tobery, SA
West, MW
Moody, K
Yang, D
Oppenheim, JJ
Friedlander, AM
AF Jelacic, Tanya M.
Chabot, Donald J.
Bozue, Joel A.
Tobery, Steven A.
West, Michael W.
Moody, Krishna
Yang, De
Oppenheim, Joost J.
Friedlander, Arthur M.
TI Exposure to Bacillus anthracis Capsule Results in Suppression of Human
Monocyte-Derived Dendritic Cells (vol 82, pg 3405, 2014)
SO INFECTION AND IMMUNITY
LA English
DT Correction
C1 [Jelacic, Tanya M.; Chabot, Donald J.; Bozue, Joel A.; Tobery, Steven A.; West, Michael W.; Friedlander, Arthur M.] US Army, Med Res Inst Infect Dis, Frederick, MD 21702 USA.
[Yang, De; Oppenheim, Joost J.] Frederick Natl Lab Canc Res, Mol Immunoregulat Lab, Frederick, MD USA.
[Moody, Krishna] Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02118 USA.
RP Jelacic, TM (reprint author), US Army, Med Res Inst Infect Dis, Frederick, MD 21702 USA.
NR 1
TC 0
Z9 0
U1 0
U2 1
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0019-9567
EI 1098-5522
J9 INFECT IMMUN
JI Infect. Immun.
PD DEC
PY 2014
VL 82
IS 12
BP 5347
EP 5347
DI 10.1128/IAI.02665-14
PG 1
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA AX5HZ
UT WOS:000346958400043
ER
PT J
AU Yet, B
Perkins, ZB
Rasmussen, TE
Tai, NRM
Marsh, DWR
AF Yet, Barbaros
Perkins, Zane B.
Rasmussen, Todd E.
Tai, Nigel R. M.
Marsh, D. William R.
TI Combining data and meta-analysis to build Bayesian networks for clinical
decision support
SO JOURNAL OF BIOMEDICAL INFORMATICS
LA English
DT Article
DE Clinical decision support; Bayesian networks; Evidence-based medicine;
Evidence synthesis; Meta-analysis
ID MODEL; REGRESSION; INFERENCE; ALGORITHM; SCORES
AB Complex clinical decisions require the decision maker to evaluate multiple factors that may interact with each other. Many clinical studies, however, report 'univariate' relations between a single factor and outcome. Such univariate statistics are often insufficient to provide useful support for complex clinical decisions even when they are pooled using meta-analysis. More useful decision support could be provided by evidence-based models that take the interaction between factors into account. In this paper, we propose a method of integrating the univariate results of a meta-analysis with a clinical dataset and expert knowledge to construct multivariate Bayesian network (BN) models. The technique reduces the size of the dataset needed to learn the parameters of a model of a given complexity. Supplementing the data with the meta-analysis results avoids the need to either simplify the model - ignoring some complexities of the problem - or to gather more data. The method is illustrated by a clinical case study into the prediction of the viability of severely injured lower extremities. The case study illustrates the advantages of integrating combined evidence into BN development: the BN developed using our method outperformed four different data-driven structure learning methods, and a well-known scoring model (MESS) in this domain. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Yet, Barbaros; Marsh, D. William R.] Queen Mary Univ London, Sch Elect Engn & Comp Sci, London E1 4NS, England.
[Perkins, Zane B.] Queen Mary Univ London, Ctr Trauma Sci, London E1 4NS, England.
[Rasmussen, Todd E.] US Army Med Res & Mat Command, Ft Detrick, MD USA.
[Tai, Nigel R. M.] Royal London Hosp, London E1 1BB, England.
RP Yet, B (reprint author), Queen Mary Univ London, Sch Elect Engn & Comp Sci, Risk & Informat Management Res Grp, Room CS332,West Sq, London E1 4NS, England.
EM b.yet@qmul.ac.uk
RI Marsh, David/A-3213-2016;
OI Marsh, David/0000-0003-0212-6363; Yet, Barbaros/0000-0003-4058-2677
NR 41
TC 3
Z9 3
U1 0
U2 11
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1532-0464
EI 1532-0480
J9 J BIOMED INFORM
JI J. Biomed. Inform.
PD DEC
PY 2014
VL 52
BP 373
EP 385
DI 10.1016/jpi.2014.07.018
PG 13
WC Computer Science, Interdisciplinary Applications; Medical Informatics
SC Computer Science; Medical Informatics
GA AY0HC
UT WOS:000347277000038
PM 25111037
ER
PT J
AU Liu, LB
Arcone, SA
AF Liu, Lanbo
Arcone, Steven A.
TI Introduction to the GPR for Hydrogeology and Groundwater Problems
Special Issue of JEEG
SO JOURNAL OF ENVIRONMENTAL AND ENGINEERING GEOPHYSICS
LA English
DT Editorial Material
C1 [Liu, Lanbo] Univ Connecticut, Sch Engn, Storrs, CT 06269 USA.
[Arcone, Steven A.] ERDC Cold Reg Res & Engn Lab, Hanover, NH 03755 USA.
RP Liu, LB (reprint author), Univ Connecticut, Sch Engn, 261 Glenbrook Rd, Storrs, CT 06269 USA.
NR 1
TC 0
Z9 0
U1 0
U2 5
PU ENVIRONMENTAL ENGINEERING GEOPHYSICAL SOC
PI DENVER
PA 1720 SOUTH BELLAIRE, STE 110, DENVER, CO 80222-433 USA
SN 1083-1363
J9 J ENVIRON ENG GEOPH
JI J. Environ. Eng. Geophys.
PD DEC
PY 2014
VL 19
IS 4
SI SI
BP 205
EP 206
DI 10.2113/JEEG19.4.205
PG 2
WC Geochemistry & Geophysics; Engineering, Geological
SC Geochemistry & Geophysics; Engineering
GA AX5DG
UT WOS:000346946600001
ER
PT J
AU Arcone, S
Campbell, S
Pfeffer, WT
AF Arcone, Steven
Campbell, Seth
Pfeffer, W. Tad
TI GPR Profiles of Glacial Till and its Transition to Bedrock:
Interpretation of Water Content, Depth and Signal Loss from Diffractions
SO JOURNAL OF ENVIRONMENTAL AND ENGINEERING GEOPHYSICS
LA English
DT Article
ID GROUND-PENETRATING RADAR; WISCONSINAN MOUNTAIN-GLACIATION; NORTHERN
PRESIDENTIAL RANGE; NEW-HAMPSHIRE; SHEET STRUCTURE; NEW-ENGLAND;
SCATTERING; ORIGIN; ATTENUATION; PROPAGATION
AB We discuss GPR reflection profiles that we recorded on glacial till and a colluvial diamict at several locations in New Hampshire, and from which we interpret water contents, depths and rates of signal loss. We used pulses centered from 150-200 MHz and 300-360 MHz. The boulder-rich sediments reside over granitic and metavolcanics, the horizons of which we recognize from the relative strengths and phase of their waveforms, underlying fractures, and well-developed diffraction asymptotes. The till produced an apparent dense distribution of diffractions with limited asymptotes and dispersion, and occasional minor stratification. We use these diffractions and moveout profiles to calculate relative dielectric permittivities between 17 and 27, values which suggest up to 30% volumetric water, and likely saturation within these over-consolidated sediments. The evidence for transitions from till to bedrock ranges from a simple horizon to complex horizon segments, all characterized by diffractions and amenable to single-layer migration. A gradational loss in diffraction strength with depth suggests gradational weathering or changes in grain size as the cause. Maximum profiled depths range from 4 m to at least 10 m, with estimated scattering attenuation rates of about 3.3 dB m(-1). In contrast, one and possible two colluvial diamicts, which likely contained 3-m-size boulders, show short segments of stratification, rare diffraction asymptotes, allow more than 20-m penetration and provide scattering losses of about 0.5 dB m(-1). We measured extremely low conductivity and calculated permittivities ranging from 9-12, which suggest high densities and volumetric water content of 4-12%. Low, single scattering loss and deep penetration in the till are consistent with evidence of ground waves traveling up to 40 m one way. The phase polarity of waveforms within till and colluvial events show they may originate from either high or low dielectric contrasts, likely related to water or large boulders, respectively.
C1 [Arcone, Steven] US Army, Cold Reg Res & Engn Lab, ERDC, Hanover, NH 03755 USA.
[Campbell, Seth] Univ Maine, Climate Change Inst, Orono, ME 04469 USA.
[Pfeffer, W. Tad] Inst Arct & Alpine Res, Boulder, CO 80309 USA.
[Pfeffer, W. Tad] Univ Colorado, Dept Civil Environm & Architectural Engn, Boulder, CO 80309 USA.
RP Arcone, S (reprint author), US Army, Cold Reg Res & Engn Lab, ERDC, 72 Lyme Rd, Hanover, NH 03755 USA.
EM Steven.A.Arcone@usace.army.mil; Seth_Campbell@umit.maine.edu;
Tad.pfeffer@Colorado.edu
FU U.S. Army Engineer Research and Development Center 6.1 program in basic
research
FX This work was supported by the U.S. Army Engineer Research and
Development Center 6.1 program in basic research. Permission to publish
was granted by the Director, Cold Regions Research and Engineering
Laboratory.
NR 51
TC 1
Z9 1
U1 4
U2 12
PU ENVIRONMENTAL ENGINEERING GEOPHYSICAL SOC
PI DENVER
PA 1720 SOUTH BELLAIRE, STE 110, DENVER, CO 80222-433 USA
SN 1083-1363
J9 J ENVIRON ENG GEOPH
JI J. Environ. Eng. Geophys.
PD DEC
PY 2014
VL 19
IS 4
SI SI
BP 207
EP 228
DI 10.2113/JEEG19.4.207
PG 22
WC Geochemistry & Geophysics; Engineering, Geological
SC Geochemistry & Geophysics; Engineering
GA AX5DG
UT WOS:000346946600002
ER
PT J
AU Turell, MJ
Dohm, DJ
Fonseca, DM
AF Turell, Michael J.
Dohm, David J.
Fonseca, Dina M.
TI COMPARISON OF THE POTENTIAL FOR DIFFERENT GENETIC FORMS IN THE CULEX
PIPIENS COMPLEX IN NORTH AMERICA TO TRANSMIT RIFT VALLEY FEVER VIRUS
SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION
LA English
DT Article
DE Transmission; form pipiens; form molestus; hybrids; vector competence;
arbovirus
ID WEST-NILE-VIRUS; MOSQUITOS DIPTERA-CULICIDAE; VECTOR COMPETENCE;
SAUDI-ARABIA; NEW-YORK; POPULATION-STRUCTURE; MOLESTUS; EPIDEMIC;
HYBRIDIZATION; AFRICA
AB Rift Valley fever virus (RVFV), a mosquito-borne virus, has been responsible for large outbreaks in Africa that have resulted in hundreds of thousands of human infections and major economic disruption due to loss of livestock and to trade restrictions. Culex pipiens was implicated as the principal vector of the Egyptian outbreak in 1977 that affected about 200,000 people. In the northern USA, Cx. pipiens occurs both as a mix of forms pipiens and molestus (i.e., US Culex pipiens) as well as pure Cx. pipiens form molestus, the latter mostly in underground locations such as sewers and basements. In order to understand the potential risk of spread of RVFV in the USA, we compared their relative abilities to transmit RVFV in the laboratory. After feeding on hamsters with high viremias, >10(9) plaque-forming units (PFU)/ml, both US Cx. pipiens and Cx. pipiens form molestus were highly susceptible to infection (similar to 80%) and about 20% of each form developed a disseminated infection. In contrast, when fed on a hamster with a moderate viremia, 10(7.5) PFU/ml, US Cx. pipiens were significantly (P < 0.001) more susceptible (84%) than were the pure form molestus (47%). Similarly, dissemination rates were significantly (P = 0.0261) higher in US Cx. pipiens (34%) than they were in pure Cx. pipiens form molestus (10%). These results underscore differences in vector competence between genetic forms in the Cx. pipiens complex but also indicate that if RVFV were to arrive in the USA, competent vectors abound in the highly urbanized Northeast.
C1 [Turell, Michael J.; Dohm, David J.] US Army, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA.
[Fonseca, Dina M.] Rutgers State Univ, Ctr Vector Biol, New Brunswick, NJ 08901 USA.
[Fonseca, Dina M.] Rutgers State Univ, Dept Entomol, New Brunswick, NJ 08901 USA.
RP Turell, MJ (reprint author), US Army, Med Res Inst Infect Dis, Div Virol, 1425 Porter St, Ft Detrick, MD 21702 USA.
OI Fonseca, Dina/0000-0003-4726-7100
FU USDA-ARS [5410-32000-015-00D, 5410-32000-018-00D]; Department of
Homeland Security Interagency Agreement [HSHQDC-07-X-00982]
FX We thank Linda McCuiston (Rutgers University) for establishing and
maintaining most mosquito colonies at the Center for Vector Biology for
>40 years and dedicate this manuscript to her-Mrs. McCuiston retired in
2014 and medical entomology is losing an invaluable resource-Denise Nash
(USAMRIID) for caring for mosquitoes, and J. Williams (USAMRIID) for
caring for the hamsters. This project was funded in part by USDA-ARS
CRIS projects 5410-32000-015-00D, 5410-32000-018-00D, and a Department
of Homeland Security Interagency Agreement HSHQDC-07-X-00982.
NR 63
TC 4
Z9 4
U1 0
U2 8
PU AMER MOSQUITO CONTROL ASSOC
PI MOUNT LAUREL
PA 15000 COMMERCE PARKWAY, SUITE C, MOUNT LAUREL, NJ 08054 USA
SN 8756-971X
EI 1943-6270
J9 J AM MOSQUITO CONTR
JI J. Am. Mosq. Control Assoc.
PD DEC
PY 2014
VL 30
IS 4
BP 253
EP 259
DI 10.2987/14-6441R.1
PG 7
WC Entomology
SC Entomology
GA AX7GQ
UT WOS:000347085200001
PM 25843130
ER
PT J
AU Kim, Y
Blank, S
AF Kim, Younkyoo
Blank, Stephen
TI Putin and Korea's "Silk Road Express": Russia's Game on the Korean
Peninsula
SO KOREA OBSERVER
LA English
DT Article
DE Russia; North Korea; Silk Road Express; Eurasia Initiative
AB Moscow has shown interest in reducing tensions on the Korean peninsula through promotion of three major trilateral (RF-DPRK-ROK) infrastructure projects: uniting the railroads in both Koreas with the Tran-Siberian Railway as well as constructing gas pipelines and power lines from Primorye to South Korea through North Korea. North Korea's "rapprochement" with Russia is both the result of moves occurring among actors in this game and, at the same time itself a stimulus to ongoing and concurrent reactions by those players. After it reviews the trilateral cooperation among Russia-North Korea-South Korea regarding the gas pipeline in 2011-2012, this article examines the trilateral cooperation regarding railways in 2013-2014.
C1 [Kim, Younkyoo] Hanyang Univ, Div Int Studies, Seoul, South Korea.
[Kim, Younkyoo] Hanyang Univ, Ctr Energy Governance & Secur EGS, Seoul, South Korea.
[Blank, Stephen] Amer Foreign Policy Council, Washington, DC USA.
[Blank, Stephen] US Army War Coll, Natl Secur Affairs Strateg Studies Inst, Carlisle, PA USA.
RP Kim, Y (reprint author), Hanyang Univ, Div Int Studies, Seoul, South Korea.
EM younkyookim@hotmail.com; blank@afpc.org
NR 31
TC 0
Z9 0
U1 1
U2 7
PU INST KOREAN STUDIES
PI SEOUL
PA CPO BOX 3410, SEOUL, 100-364, SOUTH KOREA
SN 0023-3919
J9 KOREA OBS
JI Korea Obs.
PD WIN
PY 2014
VL 45
IS 4
BP 599
EP 626
PG 28
WC Area Studies; International Relations
SC Area Studies; International Relations
GA AX2DX
UT WOS:000346754900005
ER
PT J
AU Ferguson, JB
Schultz, BF
Cho, K
Rohatgi, PK
AF Ferguson, J. B.
Schultz, Benjamin F.
Cho, Kyu
Rohatgi, Pradeep K.
TI Correlation vs. Causation: The Effects of Ultrasonic Melt Treatment on
Cast Metal Grain Size
SO METALS
LA English
DT Article
DE ultrasonic cavitation; grain refinement; metals and alloys; nucleation
ID AZ91 MAGNESIUM ALLOY; MICROSTRUCTURE; SOLIDIFICATION; TEMPERATURE
AB Interest in ultrasonic treatment of liquid metal has waxed and waned for nearly 80 years. A review of several experiments representative of ultrasonic cavitation treatment of Al and Mg alloys shows that the theoretical mechanisms thought to be responsible for grain refinement are (1) cavitation-induced increase in melting temperature predicted by the Clausius-Clapeyron equation and (2) cavitation-induced wetting of otherwise unwetted insoluble particles. Neither of these theoretical mechanisms can be directly confirmed by experiment, and though they remain speculative, the available literature generally assumes that one or the other or both mechanisms are active. However, grain size is known to depend on temperature of the liquid, temperature of the mold, and cooling rate of the entire system. From the reviewed experiments, it is difficult to isolate temperature and cooling rate effects on grain size from the theoretical effects. Ultrasonic treatments of Al-A356 were carried out to isolate such effects, and though it was found that ultrasound produced significant grain refinement, the treatments also significantly chilled the liquid and thereby reduced the pouring temperature. The grain sizes attained closely correlated with pouring temperature suggesting that ultrasonic grain refinement is predominantly a result of heat removal by the horn and ultrasonic stirring.
C1 [Ferguson, J. B.; Schultz, Benjamin F.; Rohatgi, Pradeep K.] Univ Wisconsin, Mat Sci & Engn Dept, Milwaukee, WI 53211 USA.
[Cho, Kyu] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
RP Schultz, BF (reprint author), Univ Wisconsin, Mat Sci & Engn Dept, 3200 N Cramer St, Milwaukee, WI 53211 USA.
EM jbf2@uwm.edu; bfs2@uwm.edu; kyu.c.cho2.civ@mail.mil; prohatgi@uwm.edu
FU U.S. Army Research Laboratory [W911NF-08-2-0014]
FX The authors would like to thank Scott Derse for his assistance in
performing the ultrasonic cavitation experiments. This material is based
upon work supported by the U.S. Army Research Laboratory under
Cooperative Agreement No. W911NF-08-2-0014. The views, opinions, and
conclusions made in this document are those of the authors and should
not be interpreted as representing the official policies, either
expressed or implied, of Army Research Laboratory or the U.S.
Government. The U.S. Government is authorized to reproduce and
distribute reprints for Government purposes notwithstanding any
copyright notation herein.
NR 20
TC 2
Z9 2
U1 2
U2 21
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 2075-4701
J9 METALS-BASEL
JI Metals
PD DEC
PY 2014
VL 4
IS 4
BP 477
EP 489
DI 10.3390/met4040477
PG 13
WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical
Engineering
SC Materials Science; Metallurgy & Metallurgical Engineering
GA AX4MI
UT WOS:000346906200002
ER
PT J
AU Cox, J
Luong, DD
Shunmugasamy, VC
Gupta, N
Strbik, OM
Cho, K
AF Cox, James
Luong, Dung D.
Shunmugasamy, Vasanth Chakravarthy
Gupta, Nikhil
Strbik, Oliver M., III
Cho, Kyu
TI Dynamic and Thermal Properties of Aluminum Alloy A356/Silicon Carbide
Hollow Particle Syntactic Foams
SO METALS
LA English
DT Article
DE metal matrix syntactic foam; SiC hollow particle; high strain rate
compression; damping parameter
ID METAL-MATRIX COMPOSITES; PRESSURE INFILTRATION TECHNIQUE; HIGH-STRAIN
RATES; COMPRESSIVE PROPERTIES; POWDER-METALLURGY; MECHANICAL-PROPERTIES;
DAMPING BEHAVIOR; DENSITY; MICROSTRUCTURE; MICROSPHERES
AB Aluminum alloy A356 matrix syntactic foams filled with SiC hollow particles (SiCHP) are studied in the present work. Two compositions of syntactic foams are studied for quasi-static and high strain rate compression. In addition, dynamic mechanical analysis is conducted to study the temperature dependent energy dissipation and damping capabilities of these materials. The thermal characterization includes study of the coefficient of thermal expansion (CTE). A356/SiCHP syntactic foams are not strain rate sensitive as the compressive strength displayed little variation between the tested strain rates of 0.001-2100 s(-1). Microscopic analysis of the high strain rate compression tested specimens showed that the fracture is initiated by the failure of hollow particles at the onset of the plastic deformation region. This is followed by plastic deformation of the matrix material and further crushing of particles. The syntactic foams showed decrease in storage modulus with increasing temperature and the trend was nearly linear up to 500 degrees C. The alloy shows a similar behavior at low temperature but the decrease in storage modulus increases sharply over 375 degrees C. The loss modulus is very small for the tested materials because of lack of viscoelasticity in metallic materials. The trend in the loss modulus is opposite, where the matrix alloy has lower loss modulus than syntactic foams at low temperature. However, over 250 degrees C the matrix loss modulus starts to increase rapidly and attains a peak around 460 degrees C. Syntactic foams have higher damping parameter at low temperatures than the matrix alloy. Incorporation of SiCHP helps in decreasing CTE. Compared to the CTE of the matrix alloy, 23.4 x 10(-6) degrees C-1, syntactic foams showed CTE values as low as 11.67 x 10(-6) degrees C-1.
C1 [Cox, James; Luong, Dung D.; Shunmugasamy, Vasanth Chakravarthy; Gupta, Nikhil] NYU, Polytech Sch Engn, Mech & Aerosp Engn Dept, Composite Mat & Mech Lab, Brooklyn, NY 11201 USA.
[Strbik, Oliver M., III] Deep Springs Technol LLC, Toledo, OH 43615 USA.
[Cho, Kyu] US Army, RDRL, WMMD, Aberdeen Proving Ground, MD 21005 USA.
RP Gupta, N (reprint author), NYU, Polytech Sch Engn, Mech & Aerosp Engn Dept, Composite Mat & Mech Lab, Brooklyn, NY 11201 USA.
EM jc5430@nyu.edu; ddl268@nyu.edu; vs860@nyu.edu; ngupta@nyu.edu;
ostrbik@teamdst.com; kyu.c.cho2.civ@mail.mil
RI Shunmugasamy, Vasanth Chakravarthy/P-8618-2016
OI Shunmugasamy, Vasanth Chakravarthy/0000-0003-4818-004X
FU U.S. Army Research Laboratory of DST [W911NF-10-2-0084]; NYU
[W911NF-11-2-0096]; National Science Foundation [DGE-0741714]; Central
Brooklyn STEM Initiative (CBSI); J.P. Morgan Chase Foundation; Motorola
Innovation Generation Grant; NY Space Grant Consortium; Xerox
Foundation; White Cedar Fund; Black Male Donor Collaborative, Brooklyn
Community Foundation
FX This research is sponsored by the U.S. Army Research Laboratory contract
W911NF-10-2-0084 of DST and the Cooperative Agreement W911NF-11-2-0096
with NYU. James was supported in part by the National Science Foundation
under a GK-12 Fellows grant DGE-0741714: Applying Mechatronics to
Promote Science. The program was also supported in part by the Central
Brooklyn STEM Initiative (CBSI), which is funded by the Black Male Donor
Collaborative, Brooklyn Community Foundation, J.P. Morgan Chase
Foundation, Motorola Innovation Generation Grant, NY Space Grant
Consortium, Xerox Foundation, and White Cedar Fund. Steven E. Zeltmann
is thanked for help in manuscript preparation.
NR 47
TC 9
Z9 9
U1 6
U2 38
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 2075-4701
J9 METALS-BASEL
JI Metals
PD DEC
PY 2014
VL 4
IS 4
BP 530
EP 548
DI 10.3390/met4040530
PG 19
WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical
Engineering
SC Materials Science; Metallurgy & Metallurgical Engineering
GA AX4MI
UT WOS:000346906200006
ER
PT J
AU Brennan, CVW
Walck, SD
Swab, JJ
AF Brennan, Claire V. Weiss
Walck, Scott D.
Swab, Jeffrey J.
TI A Multi-Step Transmission Electron Microscopy Sample Preparation
Technique for Cracked, Heavily Damaged, Brittle Materials
SO MICROSCOPY AND MICROANALYSIS
LA English
DT Article
DE transmission electron microscopy; sample preparation; cracked materials;
brittle materials; ceramics
AB A new technique for the preparation of heavily cracked, heavily damaged, brittle materials for examination in a transmission electron microscope (TEM) is described in detail. In this study, cross-sectional TEM samples were prepared from indented silicon carbide (SiC) bulk ceramics, although this technique could also be applied to other brittle and/or multiphase materials. During TEM sample preparation, milling-induced damage must be minimized, since in studying deformation mechanisms, it would be difficult to distinguish deformation-induced cracking from cracking occurring due to the sample preparation. The samples were prepared using a site-specific, two-step ion milling sequence accompanied by epoxy vacuum infiltration into the cracks. This technique allows the heavily cracked, brittle ceramic material to stay intact during sample preparation and also helps preserve the true microstructure of the cracked area underneath the indent. Some preliminary TEM results are given and discussed in regards to deformation studies in ceramic materials. This sample preparation technique could be applied to other cracked and/or heavily damaged materials, including geological materials, archaeological materials, fatigued materials, and corrosion samples.
C1 [Brennan, Claire V. Weiss; Swab, Jeffrey J.] US Army, Res Lab, Weap & Mat Res Directorate, Ceram & Transparent Mat Branch,RDRL WMM E, Aberdeen Proving Ground, MD 21005 USA.
[Walck, Scott D.] US Army, Res Lab, Weap & Mat Res Directorate,RDRL WMM C, Coatings Corros & Engn Polymers Branch,TKC Global, Aberdeen Proving Ground, MD 21005 USA.
RP Brennan, CVW (reprint author), US Army, Res Lab, Weap & Mat Res Directorate, Ceram & Transparent Mat Branch,RDRL WMM E, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA.
EM claire.v.brennan.civ@mail.mil
FU United States Army Research Laboratory; TKC Global
FX The authors would like to thank Wendy Sarney, Kelvin Xie, Jason
Robinnette, and Jerry LaSalvia for their help. The authors acknowledge
the United States Army Research Laboratory and TKC Global for their
support.
NR 7
TC 0
Z9 0
U1 1
U2 3
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1431-9276
EI 1435-8115
J9 MICROSC MICROANAL
JI Microsc. microanal.
PD DEC
PY 2014
VL 20
IS 6
BP 1646
EP 1653
DI 10.1017/S1431927614013257
PG 8
WC Materials Science, Multidisciplinary; Microscopy
SC Materials Science; Microscopy
GA AX9PD
UT WOS:000347233400003
ER
PT J
AU Saxer, G
Krepps, MD
Merkley, ED
Ansong, C
Kaiser, BLD
Valovska, MT
Ristic, N
Yeh, PT
Prakash, VP
Leiser, OP
Nakhleh, L
Gibbons, HS
Kreuzer, HW
Shamoo, Y
AF Saxer, Gerda
Krepps, Michael D.
Merkley, Eric D.
Ansong, Charles
Kaiser, Brooke L. Deatherage
Valovska, Marie-Therese
Ristic, Nikola
Yeh, Ping T.
Prakash, Vittal P.
Leiser, Owen P.
Nakhleh, Luay
Gibbons, Henry S.
Kreuzer, Helen W.
Shamoo, Yousif
TI Mutations in Global Regulators Lead to Metabolic Selection during
Adaptation to Complex Environments
SO PLOS GENETICS
LA English
DT Article
ID ESCHERICHIA-COLI POPULATIONS; TERM EXPERIMENTAL EVOLUTION; ADAPTIVE
RADIATION; TRANSCRIPTIONAL MICROARRAYS; ECOLOGICAL SPECIALIZATION;
MONITORING UTILIZATION; ANTIBIOTIC-RESISTANCE; BENEFICIAL MUTATIONS;
CONSTANT ENVIRONMENT; SIGNAL-TRANSDUCTION
AB Adaptation to ecologically complex environments can provide insights into the evolutionary dynamics and functional constraints encountered by organisms during natural selection. Adaptation to a new environment with abundant and varied resources can be difficult to achieve by small incremental changes if many mutations are required to achieve even modest gains in fitness. Since changing complex environments are quite common in nature, we investigated how such an epistatic bottleneck can be avoided to allow rapid adaptation. We show that adaptive mutations arise repeatedly in independently evolved populations in the context of greatly increased genetic and phenotypic diversity. We go on to show that weak selection requiring substantial metabolic reprogramming can be readily achieved by mutations in the global response regulator arcA and the stress response regulator rpoS. We identified 46 unique single-nucleotide variants of arcA and 18 mutations in rpoS, nine of which resulted in stop codons or large deletions, suggesting that subtle modulations of ArcA function and knockouts of rpoS are largely responsible for the metabolic shifts leading to adaptation. These mutations allow a higher order metabolic selection that eliminates epistatic bottlenecks, which could occur when many changes would be required. Proteomic and carbohydrate analysis of adapting E. coli populations revealed an up-regulation of enzymes associated with the TCA cycle and amino acid metabolism, and an increase in the secretion of putrescine. The overall effect of adaptation across populations is to redirect and efficiently utilize uptake and catabolism of abundant amino acids. Concomitantly, there is a pronounced spread of more ecologically limited strains that results from specialization through metabolic erosion. Remarkably, the global regulators arcA and rpoS can provide a "one-step'' mechanism of adaptation to a novel environment, which highlights the importance of global resource management as a powerful strategy to adaptation.
C1 [Saxer, Gerda; Valovska, Marie-Therese; Yeh, Ping T.; Prakash, Vittal P.; Shamoo, Yousif] Rice Univ, Dept Biosci, Houston, TX 77251 USA.
[Krepps, Michael D.; Gibbons, Henry S.] US Army Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA.
[Krepps, Michael D.] EXCET Inc, Springfield, VA USA.
[Merkley, Eric D.; Ansong, Charles; Kaiser, Brooke L. Deatherage; Kreuzer, Helen W.] Pacific NW Natl Lab, Richland, WA 99352 USA.
[Ristic, Nikola; Nakhleh, Luay] Rice Univ, Dept Comp Sci, Houston, TX USA.
[Leiser, Owen P.] No Arizona Univ, Ctr Microbial Genet & Genom, Flagstaff, AZ 86011 USA.
RP Saxer, G (reprint author), Rice Univ, Dept Biosci, Houston, TX 77251 USA.
EM gsaxer@rice.edu; shamoo@rice.edu
OI Merkley, Eric/0000-0002-5486-4723
FU Defense Threat Reduction Agency [HDTRA-1-10-1-0069, DTRA10027IA-2129];
U.S. Department of Energy [DE-AC06-76RLO]
FX This work was supported by funding from the Defense Threat Reduction
Agency (HDTRA-1-10-1-0069) to YS and (DTRA10027IA-2129) to HWK. Pacific
Northwest National Laboratory is operated by Battelle Memorial Institute
for the U.S. Department of Energy under contract DE-AC06-76RLO. The
funders had no role in study design, data collection and analysis,
decision to publish, or preparation of the manuscript.
NR 86
TC 11
Z9 11
U1 3
U2 30
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1553-7390
EI 1553-7404
J9 PLOS GENET
JI PLoS Genet.
PD DEC
PY 2014
VL 10
IS 12
AR e1004872
DI 10.1371/journal.pgen.1004872
PG 17
WC Genetics & Heredity
SC Genetics & Heredity
GA AX0NW
UT WOS:000346649900065
PM 25501822
ER
PT J
AU Schuetz, A
Deleage, C
Sereti, I
Rerknimitr, R
Phanuphak, N
Phuang-Ngern, Y
Estes, JD
Sandler, NG
Sukhumvittaya, S
Marovich, M
Jongrakthaitae, S
Akapirat, S
Fletscher, JLK
Kroon, E
Dewar, R
Trichavaroj, R
Chomchey, N
Douek, DC
O'Connell, RJ
Ngauy, V
Robb, ML
Phanuphak, P
Michael, NL
Excler, JL
Kim, JH
de Souza, MS
Ananworanich, J
AF Schuetz, Alexandra
Deleage, Claire
Sereti, Irini
Rerknimitr, Rungsun
Phanuphak, Nittaya
Phuang-Ngern, Yuwadee
Estes, Jacob D.
Sandler, Netanya G.
Sukhumvittaya, Suchada
Marovich, Mary
Jongrakthaitae, Surat
Akapirat, Siriwat
Fletscher, James L. K.
Kroon, Eugene
Dewar, Robin
Trichavaroj, Rapee
Chomchey, Nitiya
Douek, Daniel C.
O'Connell, Robert J.
Ngauy, Viseth
Robb, Merlin L.
Phanuphak, Praphan
Michael, Nelson L.
Excler, Jean-Louis
Kim, Jerome H.
de Souza, Mark S.
Ananworanich, Jintanat
CA RV254 SEARCH 010 Study Grp
RV304 SEARCH 013 Study Grp
TI Initiation of ART during Early Acute HIV Infection Preserves Mucosal
Th17 Function and Reverses HIV-Related Immune Activation
SO PLOS PATHOGENS
LA English
DT Article
ID HUMAN-IMMUNODEFICIENCY-VIRUS; REGULATORY T-CELLS; ANTIRETROVIRAL
THERAPY; MICROBIAL TRANSLOCATION; TYPE-1 INFECTION; LYMPHOID-TISSUE;
PERIPHERAL LYMPHOCYTES; LENTIVIRAL INFECTIONS; DISEASE PROGRESSION;
GENE-EXPRESSION
AB Mucosal Th17 cells play an important role in maintaining gut epithelium integrity and thus prevent microbial translocation. Chronic HIV infection is characterized by mucosal Th17 cell depletion, microbial translocation and subsequent immune-activation, which remain elevated despite antiretroviral therapy (ART) correlating with increased mortality. However, when Th17 depletion occurs following HIV infection is unknown. We analyzed mucosal Th17 cells in 42 acute HIV infection (AHI) subjects (Fiebig (F) stage I-V) with a median duration of infection of 16 days and the short-term impact of early initiation of ART. Th17 cells were defined as IL-17+ CD4+ T cells and their function was assessed by the co-expression of IL-22, IL-2 and IFN gamma. While intact during FI/II, depletion of mucosal Th17 cell numbers and function was observed during FIII correlating with local and systemic markers of immune-activation. ART initiated at FI/II prevented loss of Th17 cell numbers and function, while initiation at FIII restored Th17 cell numbers but not their polyfunctionality. Furthermore, early initiation of ART in FI/II fully reversed the initially observed mucosal and systemic immune-activation. In contrast, patients treated later during AHI maintained elevated mucosal and systemic CD8+ T-cell activation post initiation of ART. These data support a loss of Th17 cells at early stages of acute HIV infection, and highlight that studies of ART initiation during early AHI should be further explored to assess the underlying mechanism of mucosal Th17 function preservation.
C1 [Schuetz, Alexandra; Phuang-Ngern, Yuwadee; Sukhumvittaya, Suchada; Jongrakthaitae, Surat; Akapirat, Siriwat; Kroon, Eugene; Trichavaroj, Rapee; O'Connell, Robert J.; Ngauy, Viseth; de Souza, Mark S.] Armed Forces Res Inst Med Sci US Component, Dept Retrovirol, Bangkok, Thailand.
[Schuetz, Alexandra; Robb, Merlin L.; Excler, Jean-Louis; Ananworanich, Jintanat] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
[Deleage, Claire; Estes, Jacob D.] Frederick Natl Lab Canc Res, Leidos Biomed Res Inc, AIDS & Canc Virus Program, Frederick, MD USA.
[Sereti, Irini] NIAID, Clin & Mol Retrovirol Sect, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA.
[Rerknimitr, Rungsun; Phanuphak, Praphan] Chulalongkorn Univ, Fac Med, Dept Med, Bangkok 10330, Thailand.
[Phanuphak, Nittaya; Fletscher, James L. K.; Kroon, Eugene; Chomchey, Nitiya; Phanuphak, Praphan; Kim, Jerome H.; de Souza, Mark S.; Ananworanich, Jintanat] SEARCH, Bangkok, Thailand.
[Phanuphak, Nittaya; Chomchey, Nitiya; Phanuphak, Praphan; Ananworanich, Jintanat] Thai Red Cross AIDS Res Ctr, Bangkok, Thailand.
[Sandler, Netanya G.; Douek, Daniel C.] NIAID, Human Immunol Sect, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA.
[Marovich, Mary; Robb, Merlin L.; Michael, Nelson L.; Excler, Jean-Louis; Kim, Jerome H.; Ananworanich, Jintanat] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
[Dewar, Robin] NCI, Virus Isolat & Serol Lab Appl & Dev Res Directora, Frederick Inc, Frederick Canc Res & Dev Ctr, Frederick, MD 21701 USA.
RP Schuetz, A (reprint author), Armed Forces Res Inst Med Sci US Component, Dept Retrovirol, Bangkok, Thailand.
EM schuetza@afrims.org
OI Utay, Netanya/0000-0002-6407-8670
FU Henry M. Jackson Foundation for the Advancement of Military Medicine,
Inc. [W81XWH-07-2-0067]; U.S. Department of Defense (DOD)
[W81XWH-07-2-0067]; Thai Red Cross AIDS Research Center; UCLA CFAR grant
[5P30 AI028697]; NIAID/NIH
FX This work was supported by a cooperative agreement (W81XWH-07-2-0067)
between the Henry M. Jackson Foundation for the Advancement of Military
Medicine, Inc., and the U.S. Department of Defense (DOD) and by an
intramural grant from the Thai Red Cross AIDS Research Center.
Antiretroviral therapy was supported by the Thai Government
Pharmaceutical Organization, Gilead, Merck and ViiV Healthcare. The UCLA
CFAR Mucosal Immunology Core Laboratory is funded by UCLA CFAR grant
5P30 AI028697 and provided support and guidance regarding the isolation
of MMC. The work of Irini Sereti was supported by Intramural Research
Program of NIAID/NIH. The funders had no role in study design, data
collection and analysis, decision to publish, or preparation of the
manuscript.
NR 79
TC 63
Z9 63
U1 0
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1553-7366
EI 1553-7374
J9 PLOS PATHOG
JI PLoS Pathog.
PD DEC
PY 2014
VL 10
IS 12
AR e1004543
DI 10.1371/journal.ppat.1004543
PG 15
WC Microbiology; Parasitology; Virology
SC Microbiology; Parasitology; Virology
GA AX1JB
UT WOS:000346702400030
PM 25503054
ER
PT J
AU Berkowitz, JF
Page, S
Noble, CV
AF Berkowitz, Jacob F.
Page, Sanderson
Noble, Chris V.
TI Potential Disconnect Between Observations of Hydrophytic Vegetation,
Wetland Hydrology Indicators, and Hydric Soils in Unique Pitcher Plant
Bog Habitats of the Southern Gulf Coast
SO SOUTHEASTERN NATURALIST
LA English
DT Article
ID IRIS
AB The Sarracenia spp. (pitcher plant) bogs located along the southern Gulf of Mexico represent a unique natural resource characterized by endangered and endemic wetland floral communities that include a number of carnivorous plants (e.g., pitcher plants and Drosera spp. [sundews]). Despite the prevalence of obligate wetland plant species and indicators of wetland hydrology, the soils underlying this niche ecosystem often lack clear indicators of hydric soil morphology, posing challenges to wetland delineation and resource management. The National Technical Committee for Hydric Soils and an interagency team of soil scientists investigated saturated conditions and anaerobic soil conditions in pitcher plant bogs. Our results demonstrate that many of the pitcher plant-bog soils examined failed to meet an approved hydric soil indicator. Herein, we discuss potential factors preventing the formation of typical hydric soil morphologies including: low organic-matter content, high iron-concentrations, extensive bioturbation, presence of high-chroma minerals (e.g., chert), and short saturation-intervals. Our examination of soil morphology and condition in these unique and ecologically valuable habitats indicates that additional studies are required to address the apparent disconnect between observations of soils, hydrophytic vegetation, and indicators of wetland hydrology to ensure the appropriate management of these endemic natural resources.
C1 [Berkowitz, Jacob F.; Noble, Chris V.] US Army Corps Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Page, Sanderson] Nat Resources Conservat Serv, USDA, Loxey, AL 36551 USA.
RP Berkowitz, JF (reprint author), US Army Corps Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
EM Jacob.F.Berkowitz@usace.army.mil
NR 38
TC 0
Z9 0
U1 3
U2 29
PU HUMBOLDT FIELD RESEARCH INST
PI STEUBEN
PA PO BOX 9, STEUBEN, ME 04680-0009 USA
SN 1528-7092
EI 1938-5412
J9 SOUTHEAST NAT
JI Southeast. Nat.
PD DEC
PY 2014
VL 13
IS 4
BP 721
EP 734
DI 10.1656/058.013.0410
PG 14
WC Biodiversity Conservation; Ecology
SC Biodiversity & Conservation; Environmental Sciences & Ecology
GA AX8QF
UT WOS:000347173000015
ER
PT J
AU Manning, JE
Satharath, P
Gaywee, J
Lopez, MN
Lon, C
Saunders, DL
AF Manning, Jessica E.
Satharath, Prom
Gaywee, Jariyanart
Nila Lopez, Maria
Lon, Chanthap
Saunders, David L.
TI Fighting the good fight: the role of militaries in malaria elimination
in Southeast Asia
SO TRENDS IN PARASITOLOGY
LA English
DT Review
DE malaria elimination; military; Southeast Asia
ID GREATER MEKONG SUBREGION; UNCOMPLICATED PLASMODIUM-FALCIPARUM;
ISOTHERMAL AMPLIFICATION ASSAY; ARTEMISININ-RESISTANT MALARIA;
INDIVIDUAL PATIENT DATA; SUB-SAHARAN AFRICA;
DIHYDROARTEMISININ-PIPERAQUINE; ARTESUNATE-AMODIAQUINE;
GLUCOSE-6-PHOSPHATE-DEHYDROGENASE DEFICIENCY; ARTEMETHER-LUMEFANTRINE
AB Despite significant progress in malaria control in the Greater Mekong Subregion (GMS), malaria is still endemic, with more than 30 million people infected annually. Important gaps remain in case management, service delivery, prevention, and vector control, particularly in hard-to-reach mobile populations. Rapidly evolving drug resistance has created a new urgency to move aggressively toward elimination. However, no clear and cost-effective strategy has been identified. Although GMS militaries are under-recognized as a malaria transmission reservoir, they are an important focal point for elimination activities, given their high mobility, frequent malaria exposure, and potential for asymptomatic carriage. At the same time, military organizational capacity and proximity to other mobile populations could facilitate elimination efforts if relevant political barriers could be overcome. Here, we review considerations for military involvement in regional malaria elimination efforts.
C1 [Manning, Jessica E.; Lon, Chanthap; Saunders, David L.] Armed Forces Res Inst Med Sci, US Army Med Component, Dept Immunol & Med, Bangkok 10400, Thailand.
[Satharath, Prom] Royal Cambodian Armed Forces, Phnom Penh, Cambodia.
[Gaywee, Jariyanart] Royal Thai Army, Bangkok, Thailand.
[Nila Lopez, Maria] Armed Forces Philippines, Manila, Philippines.
[Lon, Chanthap] Armed Forces Res Inst Med Sci, US Army Med Component, Phnom Penh, Cambodia.
RP Saunders, DL (reprint author), Armed Forces Res Inst Med Sci, US Army Med Component, Dept Immunol & Med, Bangkok 10400, Thailand.
EM david.saunders@afrims.org
NR 90
TC 4
Z9 5
U1 0
U2 8
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1471-4922
EI 1471-5007
J9 TRENDS PARASITOL
JI Trends Parasitol.
PD DEC
PY 2014
VL 30
IS 12
BP 571
EP 581
DI 10.1016/j.pt.2014.10.002
PG 11
WC Parasitology
SC Parasitology
GA AX8DK
UT WOS:000347140400006
PM 25455566
ER
PT J
AU Kott, A
Swami, A
McDaniel, P
AF Kott, Alexander
Swami, Ananthram
McDaniel, Patrick
TI Security Outlook: Six Cyber Game Changers for the Next 15 Years
SO COMPUTER
LA English
DT Editorial Material
AB Six potential cyber game changers gleaned from a recent long-range planning symposium can help experts identify priorities for future cybersecurity research and development.
C1 [Kott, Alexander; Swami, Ananthram] US Army Res Lab, Network Sci Div, Adelphi, MD 20783 USA.
[McDaniel, Patrick] Penn State Univ, Dept Comp Sci & Engn, University Pk, PA 16802 USA.
RP Kott, A (reprint author), US Army Res Lab, Network Sci Div, Adelphi, MD 20783 USA.
EM alexander.kott1.civ@mail.mil; ananthram.swami.civ@mail.mil;
mcdaniel@cse.psu.edu
NR 5
TC 1
Z9 1
U1 1
U2 5
PU IEEE COMPUTER SOC
PI LOS ALAMITOS
PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA
SN 0018-9162
EI 1558-0814
J9 COMPUTER
JI Computer
PD DEC
PY 2014
VL 47
IS 12
BP 104
EP 106
PG 3
WC Computer Science, Hardware & Architecture; Computer Science, Software
Engineering
SC Computer Science
GA AX2IJ
UT WOS:000346766500022
ER
PT J
AU Cafasso, DE
Nishikawa, C
Schneider, P
AF Cafasso, D. E.
Nishikawa, C.
Schneider, P.
TI Reinterventions in the superficial femoral artery
SO JOURNAL OF CARDIOVASCULAR SURGERY
LA English
DT Article
DE Peripheral arterial disease; Endovascular procedures; Femoral artery;
Popliteal artery; Stents
ID IN-STENT RESTENOSIS; PACLITAXEL-ELUTING STENTS; CRITICAL LIMB ISCHEMIA;
PROXIMAL POPLITEAL ARTERIES; RESILIENT RANDOMIZED-TRIAL; LONG-TERM
OUTCOMES; BARE-METAL STENTS; 2-YEAR FOLLOW-UP; BALLOON ANGIOPLASTY;
NITINOL STENT
AB The management of peripheral arterial disease (PAD) has drastically changed since the introduction and advancement of endovascular surgery The majority of PAD that requires mechanical treatment is managed with endovascular interventions using a variety of techniques and devices. The infrainguinal vasculature, especially the superficial femoral artery (SFA), poses a significant challenge to successful long-term outcomes for a variety of reasons. Because some of these procedures have limited longevity, the management of patients that require reintervention is worthy of special consideration and strategic discussion. This article reviews the risks and failure modes of SFA interventions and the treatment options and techniques for reinterventions.
C1 [Cafasso, D. E.] Tripler Army Med Ctr, Dept Gen Surg, Honolulu, HI 96859 USA.
[Nishikawa, C.] Univ Hawaii Manoa, John A Burns Sch Med, Honolulu, HI 96822 USA.
[Schneider, P.] Dept Vasc Surg, Hawaii Permanente Med Grp, Honolulu, HI USA.
RP Schneider, P (reprint author), Kaiser Fdn Hosp, Div Vasc Therapy, 3288 Moanalua Rd, Honolulu, HI 96819 USA.
EM peter.schneider@kp.org
NR 101
TC 0
Z9 0
U1 0
U2 1
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0021-9509
EI 1827-191X
J9 J CARDIOVASC SURG
JI J. Cardiovasc. Surg.
PD DEC
PY 2014
VL 55
IS 6
BP 767
EP 777
PG 11
WC Cardiac & Cardiovascular Systems; Surgery; Peripheral Vascular Disease
SC Cardiovascular System & Cardiology; Surgery
GA AX3CL
UT WOS:000346818100005
PM 25230775
ER
PT J
AU Hoge, CW
Warner, CH
AF Hoge, Charles W.
Warner, Christopher H.
TI Estimating PTSD Prevalence in US Veterans: Considering Combat Exposure,
PTSD Checklist Cutpoints, and DSM-5
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Editorial Material
ID POSTTRAUMATIC-STRESS-DISORDER; COMORBIDITY SURVEY REPLICATION;
MENTAL-HEALTH PROBLEMS; IV DISORDERS; IRAQ; AFGHANISTAN; DEPLOYMENT;
SERVICE; ONSET
C1 [Hoge, Charles W.] Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Silver Spring, MD 20910 USA.
[Warner, Christopher H.] Army Surg Gen & Div Surg, Airborne Div 101, Ft Campbell, KY USA.
RP Hoge, CW (reprint author), Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Silver Spring, MD 20910 USA.
EM charles.hoge@us.army.mil
NR 18
TC 4
Z9 4
U1 0
U2 7
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD DEC
PY 2014
VL 75
IS 12
BP E1439
EP E1441
DI 10.4088/JCP.14com09616
PG 3
WC Psychology, Clinical; Psychiatry
SC Psychology; Psychiatry
GA AX3RL
UT WOS:000346856500004
PM 25551241
ER
PT J
AU Seren, HR
Keiser, GR
Cao, LY
Zhang, JD
Strikwerda, AC
Fan, KB
Metcalfe, GD
Wraback, M
Zhang, X
Averitt, RD
AF Seren, Huseyin R.
Keiser, George R.
Cao, Lingyue
Zhang, Jingdi
Strikwerda, Andrew C.
Fan, Kebin
Metcalfe, Grace D.
Wraback, Michael
Zhang, Xin
Averitt, Richard D.
TI Optically Modulated Multiband Terahertz Perfect Absorber
SO ADVANCED OPTICAL MATERIALS
LA English
DT Article
ID METAMATERIAL ABSORBER; DOPED SILICON; FABRICATION; FREQUENCIES;
ABSORPTION; TRANSPORT; THZ
AB Development of tunable, dynamic, and broad bandwidth metamaterial designs is a keystone objective for metamaterials research, necessary for the future viability of metamaterial optics and devices across the electromagnetic spectrum. Yet, overcoming the inherently localized, narrow bandwidth, and static response of resonant metamaterials continues to be a challenging endeavor. Resonant perfect absorbers have flourished as one of the most promising metamaterial devices with applications ranging from power harvesting to terahertz imaging. Here, an optically modulated resonant perfect absorber is presented. Utilizing photo-excited free carriers in silicon pads placed in the capacitive gaps of split ring resonators, a dynamically modulated perfect absorber is designed and fabricated to operate in reflection. Large modulation depth (38% and 91%) in two absorption bands (with 97% and 92% peak absorption) is demonstrated, which correspond to the LC (0.7 THz) and dipole (1.1 THz) modes of the split ring resonators.
C1 [Seren, Huseyin R.; Fan, Kebin; Zhang, Xin] Boston Univ, Dept Mech Engn, Boston, MA 02215 USA.
[Keiser, George R.; Cao, Lingyue; Zhang, Jingdi; Averitt, Richard D.] Boston Univ, Dept Phys, Boston, MA 02215 USA.
[Strikwerda, Andrew C.] Tech Univ Denmark, Dept Photon Engn, DK-2800 Lyngby, Denmark.
[Metcalfe, Grace D.; Wraback, Michael] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
RP Zhang, X (reprint author), Boston Univ, Dept Mech Engn, 110 Cummington Mall, Boston, MA 02215 USA.
EM xinz@bu.edu; raveritt@bu.edu
RI Zhang, Xin/B-9244-2009; Fan, Kebin/B-2984-2012
OI Zhang, Xin/0000-0002-4413-5084; Fan, Kebin/0000-0002-0275-0871
FU Air Force Office of Scientific Research [FA9550-09-1-0708]; National
Science Foundation [ECCS 1309835]; DTRA [W911NF-06-2-0040]
FX This work was supported in part by the Air Force Office of Scientific
Research under Contract FA9550-09-1-0708, the National Science
Foundation under Contract ECCS 1309835, and DTRA under Contract
W911NF-06-2-0040 administered by the Army Research Laboratory. The
authors also thank Boston University Photonics Center for technical
support.
NR 45
TC 17
Z9 18
U1 4
U2 67
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY
SN 2195-1071
J9 ADV OPT MATER
JI Adv. Opt. Mater.
PD DEC
PY 2014
VL 2
IS 12
BP 1221
EP 1226
DI 10.1002/adom.201400197
PG 6
WC Materials Science, Multidisciplinary; Optics
SC Materials Science; Optics
GA AW4PA
UT WOS:000346261900013
ER
PT J
AU Aboudara, M
Cuadrado, D
Docekal, J
Hicks, B
Mahoney, P
AF Aboudara, Matthew
Cuadrado, Daniel
Docekal, Jeremy
Hicks, Brandi
Mahoney, Peter
TI IMPACT OF PRIMARY BLAST LUNG INJURY DURING COMBAT OPERATIONS IN
AFGHANISTAN
SO CRITICAL CARE MEDICINE
LA English
DT Meeting Abstract
C1 [Aboudara, Matthew; Docekal, Jeremy] Tripler Army Med Ctr, Honolulu, HI 96859 USA.
[Cuadrado, Daniel] Madigan Army Med Ctr, Tacoma, WA 98431 USA.
[Hicks, Brandi] William Beaumont Army Med Ctr, El Paso, TX 79920 USA.
[Mahoney, Peter] Royal Ctr Def Med, Birmingham, W Midlands, England.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0090-3493
EI 1530-0293
J9 CRIT CARE MED
JI Crit. Care Med.
PD DEC
PY 2014
VL 42
IS 12
SU S
MA 1055
PG 1
WC Critical Care Medicine
SC General & Internal Medicine
GA AW3UP
UT WOS:000346211801306
ER
PT J
AU Barnard, E
Bebarta, V
AF Barnard, Ed
Bebarta, Vikhyat
TI A MODEL TO PREDICT DURATION OF VENTILATION AND 30-DAY MORTALITY IN
PATIENTS WITH TRAUMATIC INJURIES
SO CRITICAL CARE MEDICINE
LA English
DT Meeting Abstract
C1 [Barnard, Ed] Univ Hosp Birmingham NHS Fdn Trust, Barnstaple, England.
[Bebarta, Vikhyat] US Army ISR, San Antonio Mil Med Ctr, San Antonio, TX USA.
RI Bebarta, Vikhyat/M-1513-2015; bebarta, vikhyat/K-3476-2015
NR 0
TC 0
Z9 0
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0090-3493
EI 1530-0293
J9 CRIT CARE MED
JI Crit. Care Med.
PD DEC
PY 2014
VL 42
IS 12
SU S
MA 379
PG 2
WC Critical Care Medicine
SC General & Internal Medicine
GA AW3UP
UT WOS:000346211800344
ER
PT J
AU Barrett, R
Skabelund, A
Morris, M
AF Barrett, Rebecca
Skabelund, Andrew
Morris, Michael
TI AORTIC MYCETOMA FROM DISSEMINATED CUNNINGHAMELLA INFECTION
SO CRITICAL CARE MEDICINE
LA English
DT Meeting Abstract
C1 [Barrett, Rebecca] DO, Ft Sam Houston, TX USA.
[Skabelund, Andrew] San Antonio Uniformed Serv BAMC, Ft Sam Houston, TX USA.
[Morris, Michael] Brooke Army Med Ctr, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0090-3493
EI 1530-0293
J9 CRIT CARE MED
JI Crit. Care Med.
PD DEC
PY 2014
VL 42
IS 12
SU S
MA 1192
PG 1
WC Critical Care Medicine
SC General & Internal Medicine
GA AW3UP
UT WOS:000346211801413
ER
PT J
AU Bebarta, V
AF Bebarta, Vikhyat
TI COMPARISON OF PROVIDER TYPES WHO PERFORMED PREHOSPITAL LIFESAVING
INTERVENTIONS: A PROSPECTIVE STUDY
SO CRITICAL CARE MEDICINE
LA English
DT Meeting Abstract
C1 [Bebarta, Vikhyat] US Army ISR, San Antonio Mil Med Ctr, San Antonio, TX USA.
RI Bebarta, Vikhyat/M-1513-2015; bebarta, vikhyat/K-3476-2015
NR 0
TC 0
Z9 0
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0090-3493
EI 1530-0293
J9 CRIT CARE MED
JI Crit. Care Med.
PD DEC
PY 2014
VL 42
IS 12
SU S
MA 146
PG 1
WC Critical Care Medicine
SC General & Internal Medicine
GA AW3UP
UT WOS:000346211800111
ER
PT J
AU Belenkiy, S
Park, T
Baker, W
Jordan, B
Dubick, M
Salinas, J
Cancio, L
Batchinsky, A
AF Belenkiy, Slava
Park, Timothy
Baker, William
Jordan, Bryan
Dubick, Michael
Salinas, Jose
Cancio, Leopoldo
Batchinsky, Andriy
TI ASSESSING HEMORRHAGE SEVERITY WITH CONTINUOUS AUTOMATIC
HEART-RATE-COMPLEXITY MONITORING IN SWINE
SO CRITICAL CARE MEDICINE
LA English
DT Meeting Abstract
C1 [Belenkiy, Slava; Baker, William; Jordan, Bryan; Dubick, Michael; Salinas, Jose; Cancio, Leopoldo; Batchinsky, Andriy] US Army Inst Surg Res, Ft Sam Houston, TX USA.
[Park, Timothy] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0090-3493
EI 1530-0293
J9 CRIT CARE MED
JI Crit. Care Med.
PD DEC
PY 2014
VL 42
IS 12
SU S
MA 186
PG 1
WC Critical Care Medicine
SC General & Internal Medicine
GA AW3UP
UT WOS:000346211800151
ER
PT J
AU Borgman, M
Spinella, P
Pidcoke, H
Cap, A
Cannon, J
AF Borgman, Matthew
Spinella, Philip
Pidcoke, Heather
Cap, Andrew
Cannon, Jeremy
TI TRANEXAMIC ACID FOR PEDIATRIC TRAUMA
SO CRITICAL CARE MEDICINE
LA English
DT Meeting Abstract
C1 [Borgman, Matthew] San Antonio Mil Med Ctr, Ft Sm Houston, TX USA.
[Spinella, Philip] Washington Univ, St Louis, MO USA.
[Cap, Andrew] US Army Inst Surg Res, Ft Sam Houston, TX USA.
[Cannon, Jeremy] Brooke Army Med Ctr, San Antonio, TX USA.
RI Borgman, Matthew/L-9477-2015
OI Borgman, Matthew/0000-0002-2008-7380
NR 0
TC 0
Z9 0
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0090-3493
EI 1530-0293
J9 CRIT CARE MED
JI Crit. Care Med.
PD DEC
PY 2014
VL 42
IS 12
SU S
MA 1029
PG 2
WC Critical Care Medicine
SC General & Internal Medicine
GA AW3UP
UT WOS:000346211801280
ER
PT J
AU Dubick, M
Scaravilli, V
Grubbs, D
Cancio, L
Batchinsky, A
AF Dubick, Michael
Scaravilli, Vittorio
Grubbs, Dana
Cancio, Leopoldo
Batchinsky, Andriy
TI TISSUE INFLAMMATION IN AWAKE SHEEP SUBJECTED TO EXTRACORPOREAL ACID LOAD
CO2 REMOVAL (ALCO2R)
SO CRITICAL CARE MEDICINE
LA English
DT Meeting Abstract
C1 [Dubick, Michael; Scaravilli, Vittorio; Grubbs, Dana; Cancio, Leopoldo] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX USA.
[Batchinsky, Andriy] US Army Inst Surg Res, Jbsa Ft San Houston, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0090-3493
EI 1530-0293
J9 CRIT CARE MED
JI Crit. Care Med.
PD DEC
PY 2014
VL 42
IS 12
SU S
MA 683
PG 1
WC Critical Care Medicine
SC General & Internal Medicine
GA AW3UP
UT WOS:000346211800648
ER
PT J
AU Mann-Salinas, E
Caldwell, N
Serio-Melvin, M
Luellen, D
Chung, K
Cancio, L
Salinas, J
AF Mann-Salinas, Elizabeth
Caldwell, Nicole
Serio-Melvin, Maria
Luellen, David
Chung, Kevin
Cancio, Leopoldo
Salinas, Jose
TI EVALUATION OF BURN SEPSIS AUTOMATED ALERTS IN AN INTENSIVE CARE UNIT
SO CRITICAL CARE MEDICINE
LA English
DT Meeting Abstract
C1 [Mann-Salinas, Elizabeth; Caldwell, Nicole; Serio-Melvin, Maria; Luellen, David; Chung, Kevin; Cancio, Leopoldo; Salinas, Jose] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0090-3493
EI 1530-0293
J9 CRIT CARE MED
JI Crit. Care Med.
PD DEC
PY 2014
VL 42
IS 12
SU S
MA 981
PG 1
WC Critical Care Medicine
SC General & Internal Medicine
GA AW3UP
UT WOS:000346211801232
ER
PT J
AU Mondello, S
Glass, L
Schmid, K
Tortella, F
AF Mondello, Stefania
Glass, Larry
Schmid, Kara
Tortella, Frank
TI CLINICAL UTILITY OF BRAIN INJURY MARKERS IN TBI CLINICAL TRIALS:FINDINGS
FROM THE INTREPID2566 TRIAL
SO CRITICAL CARE MEDICINE
LA English
DT Meeting Abstract
C1 [Mondello, Stefania] Univ Messina, Messina, Italy.
[Glass, Larry] Neuren Pharmaceut Ltd, Silver Spring, MD USA.
[Schmid, Kara; Tortella, Frank] Walter Reed Army Inst Res, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0090-3493
EI 1530-0293
J9 CRIT CARE MED
JI Crit. Care Med.
PD DEC
PY 2014
VL 42
IS 12
SU S
MA 558
PG 1
WC Critical Care Medicine
SC General & Internal Medicine
GA AW3UP
UT WOS:000346211800523
ER
PT J
AU Pamplin, J
Murray, S
Mann-Salinas, E
Serio-Melvin, M
Huzar, T
Wolf, S
Nemeth, C
AF Pamplin, Jeremy
Murray, Sarah
Mann-Salinas, Elizabeth
Serio-Melvin, Maria
Huzar, Todd
Wolf, Steven
Nemeth, Christopher
TI CARD SORTS HELP "UNPACK" CLINICIAN PERSPECTIVES ON PATIENT CONDITION AND
TREATMENT PRIORITIES
SO CRITICAL CARE MEDICINE
LA English
DT Meeting Abstract
C1 [Murray, Sarah; Wolf, Steven] US Army Inst Surg Res, San Antonio, TX USA.
[Murray, Sarah] Geneva Fdn, San Antonio, TX USA.
[Mann-Salinas, Elizabeth; Serio-Melvin, Maria] US Army Inst Surg Res, Ft Sam Houston, TX USA.
[Huzar, Todd] Univ Texas Hlth Sci Ctr Houston, Houston, TX 77030 USA.
[Nemeth, Christopher] Appl Res Associates Inc, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0090-3493
EI 1530-0293
J9 CRIT CARE MED
JI Crit. Care Med.
PD DEC
PY 2014
VL 42
IS 12
SU S
MA 911
PG 1
WC Critical Care Medicine
SC General & Internal Medicine
GA AW3UP
UT WOS:000346211801162
ER
PT J
AU Park, T
Batchinsky, A
Baker, W
Belenkiy, S
Jordan, B
Dubick, M
Salinas, J
Cancio, L
AF Park, Timothy
Batchinsky, Andriy
Baker, William
Belenkiy, Slava
Jordan, Bryan
Dubick, Michael
Salinas, Jose
Cancio, Leopoldo
TI RESUSCITATIVE ENDOVASCULAR BALLOON OCCLUSION OF THE AORTA IMPROVES
SURVIVAL IN LETHAL HEMORRHAGE
SO CRITICAL CARE MEDICINE
LA English
DT Meeting Abstract
C1 [Park, Timothy] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA.
[Batchinsky, Andriy] US Army, Inst Surg Res, Ft San Houston, TX USA.
[Baker, William; Belenkiy, Slava; Jordan, Bryan; Dubick, Michael; Salinas, Jose; Cancio, Leopoldo] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0090-3493
EI 1530-0293
J9 CRIT CARE MED
JI Crit. Care Med.
PD DEC
PY 2014
VL 42
IS 12
SU S
MA 248
PG 1
WC Critical Care Medicine
SC General & Internal Medicine
GA AW3UP
UT WOS:000346211800213
ER
PT J
AU Salinas, J
Waters, J
Fenrich, C
Serio-Melvin, M
Graybill, J
Cancio, L
Chung, K
Stewart, I
AF Salinas, Jose
Waters, J.
Fenrich, Craig
Serio-Melvin, Maria
Graybill, John
Cancio, Leopoldo
Chung, Kevin
Stewart, Ian
TI PREVALENCE OF KIDNEY INJURY IN BURN PATIENTS REQUIRING FLUID
RESUSCITATION
SO CRITICAL CARE MEDICINE
LA English
DT Meeting Abstract
C1 [Salinas, Jose; Fenrich, Craig; Serio-Melvin, Maria; Chung, Kevin] US Army Inst Surg Res, Ft Sam Houston, TX USA.
[Waters, J.; Graybill, John] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX USA.
[Cancio, Leopoldo] US Army Inst Surg Res, San Antonio, TX USA.
[Stewart, Ian] San Antonio Mil Med Ctr, Jbsa Ft Sam Houston, TX USA.
NR 0
TC 0
Z9 0
U1 1
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0090-3493
EI 1530-0293
J9 CRIT CARE MED
JI Crit. Care Med.
PD DEC
PY 2014
VL 42
IS 12
SU S
MA 1082
PG 2
WC Critical Care Medicine
SC General & Internal Medicine
GA AW3UP
UT WOS:000346211801333
ER
PT J
AU Elward, JM
Irudayanathan, FJ
Nangia, S
Chakraborty, A
AF Elward, Jennifer M.
Irudayanathan, Flaviyan Jerome
Nangia, Shikha
Chakraborty, Arindam
TI Optical Signature of Formation of Protein Corona in the Firefly
Luciferase-CdSe Quantum Dot Complex
SO JOURNAL OF CHEMICAL THEORY AND COMPUTATION
LA English
DT Article
ID ENERGY-TRANSFER; IN-VIVO; ELECTRONIC-PROPERTIES; SURFACE LIGANDS; DNA
INTERACTION; NANOCRYSTALS; NANOMATERIALS; SPECTRA; NANOPARTICLES;
CLUSTERS
AB Theoretical investigation of protein corona is challenging because of the size of the protein-dot complex. In this work, we have addressed this computational bottleneck by combining pseudopotential + explicitly correlated HartreeFock QM calculations with molecular mechanics, molecular dynamics, and Monte Carlo techniques. The optical gap of a 5 nm CdSe quantum dot (Cd1159Se1183) was computed by sequential addition of luciferase (Lu), and a red shift of 8 nm in the lambda(max) of protein corona (CdSeLu7) was observed.
C1 [Elward, Jennifer M.] Army Res Lab, Aberdeen, MD 21005 USA.
[Chakraborty, Arindam] Syracuse Univ, Dept Chem, Syracuse, NY 13244 USA.
[Irudayanathan, Flaviyan Jerome] Syracuse Univ, Dept Biomed & Chem Engn, Syracuse, NY 13244 USA.
[Nangia, Shikha] Syracuse Univ, Syracuse Biomat Inst, Syracuse, NY 13244 USA.
RP Nangia, S (reprint author), Syracuse Univ, Syracuse Biomat Inst, Syracuse, NY 13244 USA.
EM snangia@syr.edu; archakra@syr.edu
FU National Science Foundation [CHE-1349892, ACI-1053575]; Syracuse
University
FX We thank Professor Mathew Maye for insightful discussions. This research
was funded in part by National Science Foundation grant number
CHE-1349892 and by Syracuse University. This work used the Extreme
Science and Engineering Discovery Environment (XSEDE), which is
supported by National Science Foundation grant number ACI-1053575.
NR 51
TC 6
Z9 6
U1 2
U2 15
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1549-9618
EI 1549-9626
J9 J CHEM THEORY COMPUT
JI J. Chem. Theory Comput.
PD DEC
PY 2014
VL 10
IS 12
BP 5224
EP 5228
DI 10.1021/ct500681m
PG 5
WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical
SC Chemistry; Physics
GA AW5OK
UT WOS:000346324000002
PM 26583205
ER
PT J
AU Anderson, B
Thimmesch, I
Aardsma, N
Ed, DMT
Carstater, S
Schober, J
AF Anderson, B.
Thimmesch, I.
Aardsma, N.
Ed, M. Terrell D.
Carstater, S.
Schober, J.
TI The prevalence of abnormal genital findings, vulvovaginitis, enuresis
and encopresis in children who present with allegations of sexual abuse
SO JOURNAL OF PEDIATRIC UROLOGY
LA English
DT Article
DE Vaginitis; Enuresis; Child abuse; Sexual; Pediatrics; Elimination
disorders
ID PREPUBERTAL GIRLS; GARDNERELLA-VAGINALIS; NOCTURNAL ENURESIS;
ADOLESCENTS; VICTIMS; ASSAULT; SAMPLE
AB Objective: To assess the prevalence of vulvovaginitis, enuresis and encopresis in children who were referred for allegations of sexual abuse.
Subjects: A retrospective chart review of 1280 children presenting for non-acute examination after allegations of sexual abuse during a 15-year time span. Interview documentation, physical examination documentation, urinalysis, urine and vaginal cultures were reviewed.
Results: Of the 1280 children, 73.3% were female and 26.7% male. The ages of the children ranged from 6 months to 18 years (median age was 6 years). Interviews revealed that fondling contact was the most common allegation, followed by oral, vaginal, and anal penetration. Interviews also disclosed lower urinary tract symptoms, UTI, constipation, encopresis and enuresis. Physical examination revealed no abnormal genital findings in 44.7% of cases. Examinations of the vagina noted: erythema (18.1%); hymenal notching (posterior 16.8%, anterior 4.4%); vuvlovaginitis (14.0%); laceration or transection (0.6%); and bruising (0.4%). Examination of the anus noted: anal fissure/tear (14.9%); loss of anal tone (10.6%); reflex anal dilatation (9.2%); venous congestion (3.8%); and proctitis (0.9%). Vulvovaginitis was noted in 14% (131/936) and encopresis in 2.3% (21/936). Enuresis according to age was reported in 13% of 5-9 year olds, 14.7% of 10-16 year olds and 18.2% of 17-18 year olds suspected of being abused.
Conclusion: Prevalence of vulvovaginitis and enuresis were increased, and encopresis was decreased in children with allegations of sexual abuse when compared to the general pediatric population. Physicians should continue to be aware of the possibility of the presence of these conditions in children who have been sexually abused, and offer appropriate treatment. (C) 2014 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.
C1 [Anderson, B.; Aardsma, N.; Ed, M. Terrell D.] Lake Erie Coll Osteopath Med, Erie, PA 16509 USA.
[Thimmesch, I.] Womack Army Med Ctr, Ft Bragg, NC 28307 USA.
[Carstater, S.; Schober, J.] UPMC Hamot, Dept Urol, Erie, PA 16550 USA.
[Schober, J.] Rockefeller Univ, Dept Neurobiol & Behav, New York, NY 10065 USA.
RP Schober, J (reprint author), 333 State St,Suite 201, Erie, PA 16507 USA.
EM oz265@yahoo.com; irthimmesch@gmail.com; naardsma@gmail.com;
mterrell@lecom.edu; uropa@aol.com; schobermd@aol.com
NR 35
TC 3
Z9 3
U1 0
U2 6
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1477-5131
EI 1873-4898
J9 J PEDIATR UROL
JI J. Pediatr. Urol
PD DEC
PY 2014
VL 10
IS 6
BP 1216
EP 1221
DI 10.1016/j.jpurol.2014.06.011
PG 6
WC Pediatrics; Urology & Nephrology
SC Pediatrics; Urology & Nephrology
GA AW6FI
UT WOS:000346364600044
PM 25127358
ER
PT J
AU Zhang, YH
Qian, JF
Xu, W
Russell, SM
Chen, XL
Nasybulin, E
Bhattacharya, P
Engelhard, MH
Mei, DH
Cao, RG
Ding, F
Cresce, AV
Xu, K
Zhang, JG
AF Zhang, Yaohui
Qian, Jiangfeng
Xu, Wu
Russell, Selena M.
Chen, Xilin
Nasybulin, Eduard
Bhattacharya, Priyanka
Engelhard, Mark H.
Mei, Donghai
Cao, Ruiguo
Ding, Fei
Cresce, Arthur V.
Xu, Kang
Zhang, Ji-Guang
TI Dendrite-Free Lithium Deposition with Self-Aligned Nanorod Structure
SO NANO LETTERS
LA English
DT Article
DE Electrodeposition; Li dendrite; Li nanorods; dendrite free; surface
composition
ID ELECTROSTATIC SHIELD MECHANISM; VIBRATING ELECTRODE TECHNIQUE;
ATOMIC-FORCE MICROSCOPY; LI-ION BATTERIES; METAL BATTERIES;
ELECTROCHEMICAL DEPOSITION; NONAQUEOUS ELECTROLYTES; PROPYLENE
CARBONATE; SECONDARY BATTERIES; SOLID ELECTROLYTES
AB Suppressing lithium (Li) dendrite growth is one of the most critical challenges for the development of Li metal batteries. Here, we report for the first time the growth of dendrite-free lithium films with a self-aligned and highly compacted nanorod structure when the film was deposited in the electrolyte consisting of 1.0 M LiPF6 in propylene carbonate with 0.05 M CsPF6 as an additive. Evolution of both the surface and the cross-sectional morphologies of the Li films during repeated Li deposition/stripping processes were systematically investigated. It is found that the formation of the compact Li nanorod structure is preceded by a solid electrolyte interphase (SEI) layer formed on the surface of the substrate. Electrochemical analysis indicates that an initial reduction process occurred at similar to 2.05 V vs Li/Li+ before Li deposition is responsible for the formation of the initial SEI, while the X-ray photoelectron spectroscopy indicates that the presence of CsPF6 additive can largely enhance the formation of LiF in this initial SEI. Hence, the smooth Li deposition in Cs+-containing electrolyte is the result of a synergistic effect of Cs+ additive and preformed SEI layer. A fundamental understanding on the composition, internal structure, and evolution of Li metal films may lead to new approaches to stabilize the long-term cycling stability of Li metal and other metal anodes for energy storage applications.
C1 [Zhang, Yaohui; Qian, Jiangfeng; Xu, Wu; Chen, Xilin; Nasybulin, Eduard; Bhattacharya, Priyanka; Cao, Ruiguo; Ding, Fei; Zhang, Ji-Guang] Pacific NW Natl Lab, Energy & Environm Directorate, Richland, WA 99354 USA.
[Engelhard, Mark H.] Pacific NW Natl Lab, Environm & Mol Sci Lab, Richland, WA 99354 USA.
[Mei, Donghai] Pacific NW Natl Lab, Fundamental & Computat Sci Directorate, Richland, WA 99354 USA.
[Zhang, Yaohui] Harbin Inst Technol, Dept Phys, Harbin 150001, Heilongjiang, Peoples R China.
[Qian, Jiangfeng] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Hubei, Peoples R China.
[Ding, Fei] Tianjin Inst Power Sources, Natl Key Lab Power Sources, Tianjin 300381, Peoples R China.
[Russell, Selena M.; Cresce, Arthur V.; Xu, Kang] US Army Res Lab, Sensor & Electron Devices Directorate, Adelphi, MD 20783 USA.
RP Xu, W (reprint author), Pacific NW Natl Lab, Energy & Environm Directorate, Richland, WA 99354 USA.
EM wu.xu@pnnl.gov; jiguang.zhang@pnnl.gov
RI Mei, Donghai/A-2115-2012; Bhattacharya, Priyanka/E-1652-2011; Mei,
Donghai/D-3251-2011; Cao, Ruiguo/O-7354-2016;
OI Mei, Donghai/0000-0002-0286-4182; Bhattacharya,
Priyanka/0000-0003-0368-8480; Engelhard, Mark/0000-0002-5543-0812; Xu,
Wu/0000-0002-2685-8684
FU Joint Center for Energy Storage Research, an Energy Innovation Hub -
Basic Energy Sciences, Office of Science of the U.S. DOE; DOE's Office
of Biological and Environmental Research at PNNL; National Science
Foundation of China [21103037]; Linus Pauling Distinguished Postdoctoral
Fellowship at PNNL; DOE's Batteries for Advanced Transportation
Technologies (DOE-BATT) Program
FX The research work conducted at Pacific Northwest National Laboratory
(PNNL) was supported by the Joint Center for Energy Storage Research, an
Energy Innovation Hub funded by the Basic Energy Sciences, Office of
Science of the U.S. DOE. Preliminary work on the dendrite prevention was
supported by the Assistant Secretary for Energy Efficiency and Renewable
Energy, Office of Vehicle Technology of DOE. The SEM and EDX
measurements were performed in the Environmental Molecular Sciences
Laboratory, a national scientific user facility sponsored by the DOE's
Office of Biological and Environmental Research and located at PNNL.
Y.Z. was grateful for the support from the National Science Foundation
of China (21103037). P.B. was grateful for support from a Linus Pauling
Distinguished Postdoctoral Fellowship at PNNL. The EFM work conducted at
the U.S. Army Research Laboratory (ARL) was supported by the DOE's
Batteries for Advanced Transportation Technologies (DOE-BATT) Program.
S.M.R. was supported by an appointment to the U.S. ARL Postdoctoral
Fellowship Program administered by the Oak Ridge Associated Universities
through a cooperative agreement with the U.S. ARL.
NR 52
TC 44
Z9 44
U1 48
U2 279
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1530-6984
EI 1530-6992
J9 NANO LETT
JI Nano Lett.
PD DEC
PY 2014
VL 14
IS 12
BP 6889
EP 6896
DI 10.1021/nl5039117
PG 8
WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied;
Physics, Condensed Matter
SC Chemistry; Science & Technology - Other Topics; Materials Science;
Physics
GA AW5NY
UT WOS:000346322800022
PM 25419865
ER
PT J
AU Lande, RG
AF Lande, R. Gregory
TI Stress in Service Members
SO PSYCHIATRIC CLINICS OF NORTH AMERICA
LA English
DT Article
DE Military stress; Military culture; Deployment cycle; Alcohol use
disorders; Posttraumatic stress disorder; Early interventions;
Nonpharmacologic treatment
ID MENTAL-HEALTH; MILITARY PERSONNEL; ALCOHOL-USE; NUCLEUS-ACCUMBENS;
SUBSTANCE USE; JOB STRESS; DEPLOYMENT; BEHAVIORS; PERFORMANCE; SOLDIERS
AB Military service differs from civilian jobs in the stressors that service members experience, including frequent deployments (eg, to an area of combat operations), obedience, regimentation, subordination of self to the group, integrity, and flexibility. The military culture emphasizes teamwork and peer support. In some cases, service members cannot adapt to military life, become overwhelmed by stress, or cannot overcome a traumatic experience. Clinicians should conduct a thorough evaluation guided by an understanding of the military culture. Every effort should be made to identify the stress and the maladaptive response and provide early clinical interventions to prevent progression.
C1 [Lande, R. Gregory] US Army, Med Corps, Washington, DC USA.
[Lande, R. Gregory] Walter Reed Natl Mil Med Ctr, Dept Psychiat, Psychiat Continu Serv, Bethesda, MD 20889 USA.
RP Lande, RG (reprint author), Walter Reed Natl Mil Med Ctr, Dept Psychiat, Psychiat Continu Serv, Bldg 8,4th Floor,8901 Wisconsin Ave, Bethesda, MD 20889 USA.
EM Raymond.G.Lande.civ@health.mil
NR 39
TC 2
Z9 2
U1 0
U2 8
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0193-953X
EI 1558-3147
J9 PSYCHIAT CLIN N AM
JI Psychiatr. Clin. North Amer.
PD DEC
PY 2014
VL 37
IS 4
BP 547
EP +
DI 10.1016/j.psc.2014.08.007
PG 15
WC Psychiatry
SC Psychiatry
GA AX0CB
UT WOS:000346620000006
PM 25455065
ER
PT J
AU Bryan, Z
Bryan, I
Gaddy, BE
Reddy, P
Hussey, L
Bobea, M
Guo, W
Hoffmann, M
Kirste, R
Tweedie, J
Gerhold, M
Irving, DL
Sitar, Z
Collazo, R
AF Bryan, Zachary
Bryan, Isaac
Gaddy, Benjamin E.
Reddy, Pramod
Hussey, Lindsay
Bobea, Milena
Guo, Wei
Hoffmann, Marc
Kirste, Ronny
Tweedie, James
Gerhold, Michael
Irving, Douglas L.
Sitar, Zlatko
Collazo, Ramon
TI Fermi level control of compensating point defects during metalorganic
chemical vapor deposition growth of Si-doped AlGaN
SO APPLIED PHYSICS LETTERS
LA English
DT Article
ID SEMICONDUCTORS; GAN
AB A Fermi-level control scheme for point defect management using above-bandgap UV illumination during growth is presented. We propose an extension to the analogy between the Fermi level and the electrochemical potential such that the electrochemical potential of a charged defect in a material with steady-state populations of free charge carriers may be expressed in terms of the quasi-Fermi levels. A series of highly Si-doped Al0.65Ga0.35N films grown by metalorganic chemical vapor deposition with and without UV illumination showed that samples grown under UV illumination had increased free carrier concentration, free carrier mobility, and reduced midgap photoluminescence all indicating a reduction in compensating point defects. (c) 2014 AIP Publishing LLC.
C1 [Bryan, Zachary; Bryan, Isaac; Gaddy, Benjamin E.; Reddy, Pramod; Hussey, Lindsay; Bobea, Milena; Guo, Wei; Hoffmann, Marc; Kirste, Ronny; Tweedie, James; Irving, Douglas L.; Sitar, Zlatko; Collazo, Ramon] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA.
[Gerhold, Michael] Army Res Off, Engn Sci Directorate, Res Triangle Pk, NC 27703 USA.
RP Bryan, Z (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Box 7907, Raleigh, NC 27695 USA.
OI Reddy, Pramod/0000-0002-8556-1178
FU NSF [DMR-1108071, DMR-1312582]; ARO [W911NF-04-D-0003]; ARPA-E
[DE-AR0000299]; GAANN Fellowship; NDSEG Fellowship
FX Partial financial support from NSF (DMR-1108071 and DMR-1312582), ARO
(W911NF-04-D-0003), ARPA-E (DE-AR0000299), GAANN Fellowship, and NDSEG
Fellowship was greatly appreciated.
NR 21
TC 10
Z9 10
U1 7
U2 42
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0003-6951
EI 1077-3118
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD DEC 1
PY 2014
VL 105
IS 22
AR 222101
DI 10.1063/1.4903058
PG 4
WC Physics, Applied
SC Physics
GA AW4QH
UT WOS:000346265200037
ER
PT J
AU Papa, L
LaMee, A
Tan, CN
Hill-Pryor, C
AF Papa, Linda
LaMee, Alexander
Tan, Ciara N.
Hill-Pryor, Crystal
TI Systematic Review and Meta-Analysis of Noninvasive Cranial Nerve
Neuromodulation for Nervous System Disorders
SO ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
LA English
DT Review
DE Ataxia; Brain injuries; Gait; Magnetic resonance imaging; Nervous
system; Neuronal plasticity; Postural balance; Rehabilitation;
Rehabilitation, brain injuries; Trauma; Vertigo
ID DEEP BRAIN-STIMULATION; ELECTRICAL TONGUE STIMULATION; MAJOR DEPRESSIVE
EPISODES; PARKINSONS-DISEASE; SUBTHALAMIC NUCLEUS; NEUROPLASTICITY;
REHABILITATION; EFFICACY; VNS; MODALITIES
AB Objective: To systematically review the medical literature and comprehensively summarize clinical research done on rehabilitation with a novel portable and noninvasive electrical stimulation device called the cranial nerve noninvasive neuromodulator in patients suffering from nervous system disorders.
Data Sources: PubMed, MEDLINE, and Cochrane Database of Systematic Reviews from 1966 to March 2013.
Study Selection: Studies were included if they recruited adult patients with peripheral and central nervous system disorders, were treated with the cranial nerve noninvasive neuromodulator device, and were assessed with objective measures of function.
Data Extraction: After title and abstract screening of potential articles, full texts were independently reviewed to identify articles that met inclusion criteria.
Data Synthesis: The search identified 12 publications: 5 were critically reviewed, and of these 5, 2 were combined in a meta-analysis. There were no randomized controlled studies identified, and the meta-analysis was based on pre-post studies. Most of the patients were individuals with a chronic balance dysfunction. The pooled results demonstrated significant improvements in the dynamic gait index postintervention with a mean difference of 3.45 (95% confidence interval, 1.75-5.15; P<.001), Activities-specific Balance Confidence scale with a mean difference of 16.65 (95% confidence interval, 7.65-25.47; P<.001), and Dizziness Handicap Inventory with improvements of 26.07 (95% confidence interval, -35.78 to -16.35; P<.001). Included studies suffered from small sample sizes, lack of randomization, absence of blinding, use of referral populations, and variability in treatment schedules and follow-up rates.
Conclusions: Given these limitations, the results of the meta-analysis must be interpreted cautiously. Further investigation using rigorous randomized controlled trials is needed to evaluate this promising rehabilitation tool for nervous system disorders. (C) 2014 by the American Congress of Rehabilitation Medicine
C1 [Papa, Linda; Tan, Ciara N.] Orlando Reg Med Ctr Inc, Dept Emergency Med, Orlando, FL 32806 USA.
[LaMee, Alexander] Univ Cent Florida, Dept Biomed Sci, Orlando, FL 32816 USA.
[Hill-Pryor, Crystal] US Army, Med Res & Mat Command, Combat Casualty Care Res Program, Ft Detrick, MD USA.
RP Papa, L (reprint author), Orlando Reg Med Ctr Inc, Dept Emergency Med, 86 W Underwood S-200, Orlando, FL 32806 USA.
EM lpstat@aol.com
NR 40
TC 0
Z9 0
U1 2
U2 12
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0003-9993
EI 1532-821X
J9 ARCH PHYS MED REHAB
JI Arch. Phys. Med. Rehabil.
PD DEC
PY 2014
VL 95
IS 12
BP 2435
EP 2443
DI 10.1016/j.apmr.2014.04.018
PG 9
WC Rehabilitation; Sport Sciences
SC Rehabilitation; Sport Sciences
GA AW0AY
UT WOS:000345954000027
PM 24814561
ER
PT J
AU Griggs, CS
Barber, PS
Kelley, SP
Moser, RD
Seiter, JM
Thomas, CC
Coleman, JG
Medina, VF
Rogers, RD
AF Griggs, C. S.
Barber, P. S.
Kelley, S. P.
Moser, R. D.
Seiter, J. M.
Thomas, C. C.
Coleman, J. G.
Medina, V. F.
Rogers, R. D.
TI Biomimetic Mineralization of Uranium by Metabolically-Inactive Shrimp
Shell
SO CRYSTAL GROWTH & DESIGN
LA English
DT Article
ID AMORPHOUS CALCIUM-CARBONATE; BIOMINERALIZATION; HYDROXYAPATITE;
SOLUBILITY; CHEMISTRY; CRAYFISH; SORPTION; SYSTEMS; SOILS
AB Biomineralization in crustaceans is a remarkably efficient process of ion transport and phase transformation in a spatial template. Here we show the use of this preorganized pathway with waste shrimp shell as both a phosphate source and template for the mineralization of UO22+ to uramphite. By using the physical structural and chemical reservoir of the biogenic platform, the only requirement was to develop a solution for ion supply. Hydroxylammonium acetate, an amphiprotic salt parallel to the amine and carboxylic acid motif pervasive in biomolecules, was prepared and used for the delivery of dissolved uranyl ions into the spatial constraints of the exoskeleton. Although biomediated phase transformations of exogenous metals is typically limited to living organisms, our results show that metabolically inactive shrimp shells are adaptive and responsive toward a nonessential ion. This suggests the nonliving exoskeleton may provide rapid bottom-up assembly routes to technologically important new inorganic crystalline materials.
C1 [Griggs, C. S.; Barber, P. S.; Kelley, S. P.; Rogers, R. D.] Univ Alabama, Ctr Green Mfg, Tuscaloosa, AL 35487 USA.
[Griggs, C. S.; Barber, P. S.; Kelley, S. P.; Rogers, R. D.] Univ Alabama, Dept Chem, Tuscaloosa, AL 35487 USA.
[Griggs, C. S.; Moser, R. D.; Seiter, J. M.; Thomas, C. C.; Coleman, J. G.; Medina, V. F.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
[Griggs, C. S.; Moser, R. D.; Seiter, J. M.; Thomas, C. C.; Coleman, J. G.; Medina, V. F.] US Army Engineer Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA.
RP Rogers, RD (reprint author), Univ Alabama, Ctr Green Mfg, Tuscaloosa, AL 35487 USA.
EM rdrogers@ua.edu
OI Rogers, Robin D./0000-0001-9843-7494
FU DOE Office of Nuclear Energy Nuclear Energy University Programs
[DE-NE0000672]; Environmental Security Technology Certification Program
(ESTCP) [ER-201321]; U.S. Department of Energy (DOE), Geosciences
[DE-FG02-92ER14244]; DOE, Office of Science, Office of Basic Energy
Sciences [DE-AC02-98CH10886]
FX The UA authors would like to thank the DOE Office of Nuclear Energy
Nuclear Energy University Programs grant #DE-NE0000672 for support of
this work. Additional research support was provided by the Environmental
Security Technology Certification Program (ESTCP) project ER-201321. The
authors also thank the Gulf Coast Agricultural and Seafood Cooperative
in Bayou La Batre, AL for providing the shrimp shell. Portions of this
work were performed at Beamline X27A, National Synchrotron Light Source
(NSLS), Brookhaven National Laboratory. X27A is supported in part by the
U.S. Department of Energy (DOE), Geosciences (DE-FG02-92ER14244 to The
University of Chicago-CARS). Use of the NSLS was supported by the DOE,
Office of Science, Office of Basic Energy Sciences, under Contract No.
DE-AC02-98CH10886.
NR 30
TC 4
Z9 4
U1 3
U2 29
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1528-7483
EI 1528-7505
J9 CRYST GROWTH DES
JI Cryst. Growth Des.
PD DEC
PY 2014
VL 14
IS 12
BP 6172
EP 6176
DI 10.1021/cg5015576
PG 5
WC Chemistry, Multidisciplinary; Crystallography; Materials Science,
Multidisciplinary
SC Chemistry; Crystallography; Materials Science
GA AU9AJ
UT WOS:000345884000003
ER
PT J
AU Armanious, MMH
Olaya, SVB
Tyo, JS
Skipper, MC
Abdalla, MD
Altgilbers, LL
Bryan, A
AF Armanious, Miena M. H.
Olaya, Sandra V. Bernal
Tyo, J. Scott
Skipper, Michael C.
Abdalla, Michael D.
Altgilbers, Larry L.
Bryan, Austen
TI An Electrically Small Conical Folded Dipole Antenna for Use as a
Compact, Self-Resonant Mesoband High-Power Microwave Source
SO IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION
LA English
DT Article
DE Antennas; high power microwaves
ID WIDE-BAND SOURCE
AB Mesoband (MB) high-power microwave (HPM) sources use fast-risetime switches to trigger weak resonators in order to create a damped sinusoidal waveform. MB sources are more compact and less complicated than narrowband HPM sources, and they possess increased energy spectral density per pulse relative to ultrawideband HPM sources. In this paper we consider the design of a MB HPM system that operates at the low end of the VHF spectrum (below 50 MHz) that is based on a self-resonant, electrically small antenna (ESA). The ESA is based on a conical folded helix design. It is slowly charged up to high voltage, and it is then switched using a fast-rise time switch to convert the stored static energy into radiated electromagnetic fields. Here we show the design, modeling, and preliminary experimental results of the source operating as low as 38 MHz at an electrical size of, where is the radius of a sphere circumscribing the source. Experimental results are obtained in the far field for a charge voltage of 30 kV.
C1 [Armanious, Miena M. H.; Olaya, Sandra V. Bernal; Tyo, J. Scott] Univ Arizona, Ctr Opt Sci, Tucson, AZ 85721 USA.
[Skipper, Michael C.; Abdalla, Michael D.] ASR Corp, Albuquerque, NM 87131 USA.
[Altgilbers, Larry L.] US Army Space & Missile Def Command, Huntsville, AL 35807 USA.
[Bryan, Austen] Missile Def Agcy, Albuquerque, NM 87117 USA.
RP Armanious, MMH (reprint author), Univ Arizona, Ctr Opt Sci, Tucson, AZ 85721 USA.
EM tyo@ieee.org
FU STTR Contract from the Missile Defense Agency
FX This work was supported by a Phase I/Phase II STTR Contract from the
Missile Defense Agency.
NR 18
TC 3
Z9 3
U1 0
U2 9
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0018-926X
EI 1558-2221
J9 IEEE T ANTENN PROPAG
JI IEEE Trans. Antennas Propag.
PD DEC
PY 2014
VL 62
IS 12
BP 5960
EP 5967
DI 10.1109/TAP.2014.2360549
PG 8
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA AU8LY
UT WOS:000345849100003
ER
PT J
AU Talladay, TG
Templeton, DW
AF Talladay, Timothy G.
Templeton, Douglas W.
TI Glass Armor - An Overview
SO INTERNATIONAL JOURNAL OF APPLIED GLASS SCIENCE
LA English
DT Article
ID TRANSPARENT; CERAMICS
AB Transparent armor for military vehicles has recently gained renewed attention. However the ballistic impact and penetration processes of glass armors are not well understood. Different types of glasses exhibit different ballistic responses, and a pressing need exists to better comprehend and model these responses in order to develop lightweight armors. The need to better understand the processes of densification and dynamic fracture and the need for input and validation data for continuum models are highlighted as examples.
C1 [Talladay, Timothy G.; Templeton, Douglas W.] US Army Tank Automot Res Dev & Engn Ctr, Warren, MI 48397 USA.
RP Talladay, TG (reprint author), US Army Tank Automot Res Dev & Engn Ctr, Warren, MI 48397 USA.
EM timothy.g.talladay.civ@mail.mil
NR 19
TC 1
Z9 1
U1 4
U2 18
PU WILEY PERIODICALS, INC
PI SAN FRANCISCO
PA ONE MONTGOMERY ST, SUITE 1200, SAN FRANCISCO, CA 94104 USA
SN 2041-1286
EI 2041-1294
J9 INT J APPL GLASS SCI
JI Int. J. Appl. Glass Sci.
PD DEC
PY 2014
VL 5
IS 4
SI SI
BP 331
EP 333
DI 10.1111/ijag.12096
PG 3
WC Materials Science, Ceramics
SC Materials Science
GA AW0MY
UT WOS:000345987800002
ER
PT J
AU Swab, JJ
Patel, PJ
Tran, X
Gilde, L
Luoto, E
Gaviola, MH
Gott, A
Paulson, B
Kilczewski, S
AF Swab, Jeffrey J.
Patel, Parimal J.
Tran, Xuan
Gilde, Luke
Luoto, Ernest
Gaviola, Mariel H.
Gott, Ashley
Paulson, Blake
Kilczewski, Steven
TI Equibiaxial Flexure Strength of Glass: Influence of Glass Plate Size and
Equibiaxial Ring Ratio
SO INTERNATIONAL JOURNAL OF APPLIED GLASS SCIENCE
LA English
DT Article
ID FLOAT GLASS; DYNAMIC FATIGUE; SILICA GLASS; COATINGS; SURFACES; STRESS
AB Glass plays an important role in many engineering applications including transparent armor. Determining the actual strength of a glass is problematic because typical glass strength numbers are presented in the literature as ranges. Minor changes in surface finish, composition, test method employed, and processing all influence the mechanical strength of glass. A standardized method needs to be utilized to ensure that strength data can be compared universally. The use of a standard methodology is vital when comparing glass compositions or multiple sample lots of the same composition in order to attribute any real strength variations to the glass itself. While the procedures established in ASTM C1499 provide a good framework for glass strength measurement, flexibility in the experimental parameters of the standard allow for substantial strength variations when testing glass materials. The ratio between the load and support ring diameters, as well as the specimen dimensions, is shown to lead to variations in both the measured strength, as well as the number of valid/invalid tests based on where fracture initiates. The goal of this study is to quantify these effects in order to establish optimized testing conditions for determining the strength of float glass.
C1 [Swab, Jeffrey J.; Patel, Parimal J.; Tran, Xuan; Gilde, Luke; Luoto, Ernest; Gaviola, Mariel H.; Gott, Ashley; Paulson, Blake; Kilczewski, Steven] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
[Tran, Xuan; Gaviola, Mariel H.] Aberdeen High Sch, Sci & Math Acad, Senior Capstone Project, Aberdeen, MD USA.
[Luoto, Ernest] Cecil Cty Community Coll, Elkton, MD 21921 USA.
[Gott, Ashley] Univ Maryland, College Pk, MD USA.
[Paulson, Blake] Harford Community Coll, Churchville, MD USA.
RP Swab, JJ (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
EM jeffrey.j.swab.civ@mail.mil
FU USARL; US Department of Energy
FX Work performed through support by an appointment to the Research
Participation Program at the US Army Research Laboratory (USARL)
administered by the Oak Ridge Institute for Science and Education
through an interagency agreement between USARL and the US Department of
Energy.
NR 19
TC 2
Z9 2
U1 0
U2 5
PU WILEY PERIODICALS, INC
PI SAN FRANCISCO
PA ONE MONTGOMERY ST, SUITE 1200, SAN FRANCISCO, CA 94104 USA
SN 2041-1286
EI 2041-1294
J9 INT J APPL GLASS SCI
JI Int. J. Appl. Glass Sci.
PD DEC
PY 2014
VL 5
IS 4
SI SI
BP 384
EP 392
DI 10.1111/ijag.12094
PG 9
WC Materials Science, Ceramics
SC Materials Science
GA AW0MY
UT WOS:000345987800008
ER
PT J
AU Coleman, LS
Ford, WM
Dobony, CA
Britzke, ER
AF Coleman, Laci S.
Ford, W. Mark
Dobony, Chris A.
Britzke, Eric R.
TI A Comparison of Passive and Active Acoustic Sampling for a Bat Community
Impacted by White-Nose Syndrome
SO JOURNAL OF FISH AND WILDLIFE MANAGEMENT
LA English
DT Article
DE acoustics; active sampling; bats; detection probability; occupancy
analysis; passive sampling
ID ECHOLOCATION CALLS; MYOTIS-SODALIS; OCCUPANCY; DETECTORS;
IDENTIFICATION; INVENTORY; PROTOCOL; FOREST; RATES
AB In the summers of 2011 and 2012, we compared passive and active acoustic sampling for bats at 31 sites at Fort Drum Military Installation, New York. We defined active sampling as acoustic sampling that occurred in 30-min intervals between the hours of sunset and 0200 with a user present to manipulate the directionality of the microphone. We defined passive sampling as acoustic sampling that occurred over a 12-h period (1900-0700 hours) without a user present and with the microphone set in a predetermined direction. We detected seven of the nine possible species at Fort Drum, including the federally endangered Indiana bat Myotis sodalis, the proposed-for-listing northern bat M. septentrionalis, the little brown bat M. lucifugus, and the big brown bat Eptesicus fuscus, which are impacted by white-nose syndrome (WNS); and the eastern red bat Lasiurus borealis, the hoary bat L. cinereus, and the silver-haired bat Lasionycteris noctivagans, which are not known to be impacted by WNS. We did not detect two additional WNS-impacted species known to historically occur in the area: the eastern small-footed bat Myotis leibii and the tri-colored bat Perimyotis subflavus. Single-season occupancy models revealed lower detection probabilities of all detected species using active sampling versus passive sampling. Additionally, overall detection probabilities declined in detected WNS-impacted species between years. A paired t-test of simultaneous sampling on 21 occasions revealed that overall recorded foraging activity per hour was greater using active than passive sampling for big brown bats and greater using passive than active sampling for little brown bats. There was no significant difference in recorded activity between methods for other WNS-impacted species, presumably because these species have been so reduced in number that their "apparency" on the landscape is lower. Finally, a cost analysis of standard passive and active sampling protocols revealed that passive sampling is substantially more cost-effective than active sampling per hour of data collection. We recommend passive sampling over active sampling methodologies as they are defined in our study for detection probability and/or occupancy studies focused on declining bat species in areas that have experienced severe WNS-associated impacts.
C1 [Coleman, Laci S.] Virginia Polytech Inst & State Univ, Dept Fisheries & Wildlife Conservat, Blacksburg, VA 24061 USA.
[Ford, W. Mark] Virginia Polytech Inst & State Univ, Dept Fisheries & Wildlife Conservat, Virginia Cooperat Fish & Wildlife Res Unit, US Geol Survey, Blacksburg, VA 24061 USA.
[Dobony, Chris A.] Ft Drum Mil Installat, Nat Resources Branch, Ft Drum, NY 13602 USA.
[Britzke, Eric R.] US Army Engn Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Ford, WM (reprint author), Virginia Polytech Inst & State Univ, Dept Fisheries & Wildlife Conservat, Virginia Cooperat Fish & Wildlife Res Unit, US Geol Survey, 106 Cheatham Hall, Blacksburg, VA 24061 USA.
EM wmford@vt.edu
FU Fort Drum Natural Resources Branch through National Park Service,
Southern Appalachian Cooperative Ecosystem Study Unit
[W9126G-11-2-SOI-0029]; U.S. Geological Survey Cooperative Research Unit
Research Work Order [VA-RWO-142]
FX Funding for this study was provided by the Fort Drum Natural Resources
Branch through National Park Service, Southern Appalachian Cooperative
Ecosystem Study Unit contract W9126G-11-2-SOI-0029 and the U.S.
Geological Survey Cooperative Research Unit Research Work Order
VA-RWO-142. We thank R. Rainbolt, A. Dale, S. Dedrick, G. Luongo, and N.
Grosse for field assistance. Earlier drafts of this manuscript were
reviewed by D. Stauffer and J.B. Johnson. Additionally, this manuscript
received helpful peer review from the Subject Editor and two anonymous
reviewers.
NR 38
TC 1
Z9 3
U1 9
U2 265
PU U S FISH & WILDLIFE SERVICE
PI SHEPHERDSTOWN
PA NATL CONSERVATION TRAINING CENTER, CONSERVATION LIBRARY, 698
CONSERVATION WAY, SHEPHERDSTOWN, WV 25443 USA
SN 1944-687X
J9 J FISH WILDL MANAG
JI J. Fish Wildl. Manag.
PD DEC
PY 2014
VL 5
IS 2
BP 217
EP 226
DI 10.3996/082103-JFWM-057
PG 10
WC Biodiversity Conservation; Ecology
SC Biodiversity & Conservation; Environmental Sciences & Ecology
GA AW1MA
UT WOS:000346052300003
ER
PT J
AU Neiman, PJ
Gottas, DJ
White, AB
Schick, LJ
Ralph, FM
AF Neiman, Paul J.
Gottas, Daniel J.
White, Allen B.
Schick, Lawrence J.
Ralph, F. Martin
TI The Use of Snow-Level Observations Derived from Vertically Profiling
Radars to Assess Hydrometeorological Characteristics and Forecasts over
Washington's Green River Basin
SO JOURNAL OF HYDROMETEOROLOGY
LA English
DT Article
DE Hydrometeorology; Orographic effects; Radars; Radar observations; Wind
profilers; Forecast verification; skill
ID ATMOSPHERIC RIVERS; PACIFIC-NORTHWEST; MELTING LAYER; SIERRA-NEVADA;
OROGRAPHIC PRECIPITATION; NORTHERN CALIFORNIA; MOUNTAIN SNOWPACK;
SATELLITE; COAST; FLOW
AB Two vertically pointing S-band radars (coastal and inland) were operated in western Washington during two winters to monitor brightband snow-level altitudes. Similar snow-level characteristics existed at both sites, although the inland site exhibited lower snow levels by similar to 70 m because of proximity to cold continental air, and snow-level altitude changes were delayed there by several hours owing to onshore translation of weather systems. The largest precipitation accumulations and rates occurred when the snow level was largely higher than the adjacent terrain. A comparison of these observations with long-term operational radiosonde data reveals that the radar snow levels mirrored climatological conditions. The inland radar data were used to assess the performance of nearby operational freezing-level forecasts. The forecasts possessed a lower-than-observed bias of 100-250 m because of a combination of forecast error and imperfect representativeness between the forecast and observing points. These forecast discrepancies increased in magnitude with higher observed freezing levels, thus representing the hydrologically impactful situations where a greater fraction of mountain basins receive rain rather than snow and generate more runoff than anticipated. Vertical directional wind shear calculations derived from wind-profiler data, and concurrent surface temperature data, reveal that most snow-level forecast discrepancies occurred with warm advection aloft and low-level cold advection through the Stampede Gap. With warm advection, forecasts were too high (low) for observed snow levels below (above) 1.25 km MSL. An analysis of sea level pressure differences across the Cascades indicated that mean forecasts were too high (low) for observed snow levels below (above) 1.25 km MSL when higher pressure was west (east) of the range.
C1 [Neiman, Paul J.; Gottas, Daniel J.; White, Allen B.] NOAA ESRL Phys Sci Div, Boulder, CO 80305 USA.
[Schick, Lawrence J.] US Army Corps Engineers, Seattle, WA USA.
[Ralph, F. Martin] Univ Calif San Diego, Scripps Inst Oceanog, La Jolla, CA 92093 USA.
RP Neiman, PJ (reprint author), NOAA ESRL Phys Sci Div, 325 Broadway, Boulder, CO 80305 USA.
EM paul.j.neiman@noaa.gov
FU NOAA/ESRL/PSD; NOAA
FX This study benefited greatly from the support of the talented
engineering and technical team at NOAA/ESRL/PSD; they built, deployed,
and maintained the radars used in this study. In particular, we
acknowledge James Jordan and Clark King for managing the staff and field
deployments. We thank the city of Westport, WA, for providing a radar
site there. We also thank Pierce County and the city of Tacoma/Tacoma
Water for providing the Ravensdale radar site. This work was supported
by NOAA's Hydrometeorological Testbed program and Office of Oceanic and
Atmospheric Research, by the NWS Office of Science and Technology, and
by the NWS Office of Hydrologic Development. We are grateful for the
comments and suggestions offered by two anonymous reviewers. Their
efforts improved the scope and quality of this study.
NR 41
TC 1
Z9 1
U1 1
U2 7
PU AMER METEOROLOGICAL SOC
PI BOSTON
PA 45 BEACON ST, BOSTON, MA 02108-3693 USA
SN 1525-755X
EI 1525-7541
J9 J HYDROMETEOROL
JI J. Hydrometeorol.
PD DEC
PY 2014
VL 15
IS 6
BP 2522
EP 2541
DI 10.1175/JHM-D-14-0019.1
PG 20
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA AU9FZ
UT WOS:000345898400024
ER
PT J
AU Suffczynski, P
Crone, NE
Franaszczuk, PJ
AF Suffczynski, Piotr
Crone, Nathan E.
Franaszczuk, Piotr J.
TI Afferent inputs to cortical fast-spiking interneurons organize pyramidal
cell network oscillations at high-gamma frequencies (60-200 Hz)
SO JOURNAL OF NEUROPHYSIOLOGY
LA English
DT Article
DE cortex; high-gamma; model; oscillations
ID LOCAL-FIELD POTENTIALS; PRIMARY VISUAL-CORTEX; SOMATOSENSORY CORTEX;
INHIBITORY INTERNEURONS; ELECTRICAL SYNAPSES; MOTOR CORTEX; NEURONS;
HIPPOCAMPUS; MECHANISMS; NEOCORTEX
AB High-gamma activity, ranging in frequency between similar to 60 Hz and 200 Hz, has been observed in local field potential, electrocorticography, EEG and magnetoencephalography signals during cortical activation, in a variety of functional brain systems. The origin of these signals is yet unknown. Using computational modeling, we show that a cortical network model receiving thalamic input generates high-gamma responses comparable to those observed in local field potential recorded in monkey somatosensory cortex during vibrotactile stimulation. These high-gamma oscillations appear to be mediated mostly by an excited population of inhibitory fast-spiking interneurons firing at high-gamma frequencies and pacing excitatory regular-spiking pyramidal cells, which fire at lower rates but in phase with the population rhythm. The physiological correlates of high-gamma activity, in this model of local cortical circuits, appear to be similar to those proposed for hippocampal ripples generated by subsets of interneurons that regulate the discharge of principal cells.
C1 [Suffczynski, Piotr] Univ Warsaw, Inst Expt Phys, Dept Biomed Phys, PL-02093 Warsaw, Poland.
[Suffczynski, Piotr; Crone, Nathan E.; Franaszczuk, Piotr J.] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA.
[Franaszczuk, Piotr J.] US Army, Res Lab, Human Res & Engn Directorate, Aberdeen, MD USA.
RP Suffczynski, P (reprint author), Univ Warsaw, Inst Expt Phys, Dept Biomed Phys, Pasteura 5, PL-02093 Warsaw, Poland.
EM suffa@fuw.edu.pl
RI Franaszczuk, Piotr/B-6532-2008
OI Franaszczuk, Piotr/0000-0002-5166-4224
FU National Institute of Neurological Disorders and Stroke [NS-40596];
Kosciuszko Foundation
FX This work was supported by National Institute of Neurological Disorders
and Stroke Grant NS-40596. P. Suffczynski was partly sponsored by a
fellowship from the Kosciuszko Foundation.
NR 58
TC 5
Z9 5
U1 0
U2 13
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-3077
EI 1522-1598
J9 J NEUROPHYSIOL
JI J. Neurophysiol.
PD DEC 1
PY 2014
VL 112
IS 11
BP 3001
EP 3011
DI 10.1152/jn.00844.2013
PG 11
WC Neurosciences; Physiology
SC Neurosciences & Neurology; Physiology
GA AW1AN
UT WOS:000346023000025
PM 25210164
ER
PT J
AU Childs, JD
Harman, JS
Rodeghero, JR
Horn, M
George, SZ
AF Childs, John D.
Harman, Jeffrey S.
Rodeghero, Jason R.
Horn, Maggie
George, Steven Z.
TI Implications of Practice Setting on Clinical Outcomes and Efficiency of
Care in the Delivery of Physical Therapy Services
SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY
LA English
DT Article
DE cost; health services research; hospital; private practice;
rehabilitation
ID COMPUTERIZED ADAPTIVE TEST; LOW-BACK-PAIN; RESPONSIVE MEASURES; KNEE
IMPAIRMENTS; COSTS; VALIDITY; EPISODES; HIP
AB STUDY DESIGN: Retrospective analysis of episodes of care.
OBJECTIVE: To assess the implications of practice setting (hospital outpatient settings versus private practice) on clinical outcomes and efficiency of care in the delivery of physical therapy services.
BACKGROUND: Many patients with musculoskeletal conditions benefit from care provided by physical therapists. The majority of physical therapists deliver services in either a private practice setting or in a hospital outpatient setting. There have not been any recent studies comparing whether clinical outcomes or efficiency of care differ based on practice setting.
METHODS: Practices that use the Focus On Therapeutic Outcomes, Inc system were surveyed to determine the specific type of setting in which outcomes were collected in patients with musculoskeletal impairments. Patient outcome data over 12 months (2011-2012) were extracted from the database and analyzed to identify differences in the functional status achieved and the efficiency of the care delivery process between private practices and hospital outpatient settings.
RESULTS: The data suggest that patients experience more efficient care when receiving physical therapy in hospital outpatient settings compared to private practice settings, as demonstrated by 3.1 points of greater improvement in functional status over 2.9 fewer physical therapy visits. However, the difference in improvement between settings is less than the minimum clinically important difference of 9 points in functional status outcome score.
CONCLUSION: In this cohort, our data suggest that more efficient care was delivered in the hospital outpatient setting compared to the private practice setting. However, we cannot conclude that care delivered in the hospital setting is more cost-effective, because it is possible that any difference in efficiency of care favoring the hospital outpatient setting is more than offset by higher costs of care.
C1 [Childs, John D.] Baylor Univ, US Army, Doctoral Program Phys Therapy, Ft Sam Houston, TX USA.
[Harman, Jeffrey S.] Univ Florida, Coll Publ Hlth & Hlth Profess, Dept Hlth Serv Res Management & Policy, Gainesville, FL USA.
[Rodeghero, Jason R.] OSF St James John W Albrecht Med Ctr, Pontiac, IL USA.
[Horn, Maggie] Langston Univ, Sch Phys Therapy, Langston, OK USA.
[George, Steven Z.] Univ Florida, Ctr Pain Res & Behav Treatment, Dept Phys Therapy, Gainesville, FL USA.
RP Childs, JD (reprint author), Evidence Mot, 17325 Bell North Dr,Suite 2B, Schertz, TX 78154 USA.
EM childsjd@gmail.com
NR 33
TC 4
Z9 4
U1 0
U2 4
PU J O S P T,
PI ALEXANDRIA
PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA
SN 0190-6011
J9 J ORTHOP SPORT PHYS
JI J. Orthop. Sports Phys. Ther.
PD DEC
PY 2014
VL 44
IS 12
BP 955
EP 963
DI 10.2519/jospt.2014.5224
PG 9
WC Orthopedics; Rehabilitation; Sport Sciences
SC Orthopedics; Rehabilitation; Sport Sciences
GA AW2IR
UT WOS:000346111900006
PM 25350133
ER
PT J
AU Moore, N
Altman, DE
Vuong, CV
Sousa, JC
Marcsisin, SR
Zottig, VE
Genovese, RF
AF Moore, Nicole
Altman, Daniel E.
Vuong, Chau V.
Sousa, Jason C.
Marcsisin, Sean R.
Zottig, Victor E.
Genovese, Raymond F.
TI Developmental Status Shapes Physiological and Behavioral Responses to
Traumatic Stress Exposures in Male Rats
SO NEUROPSYCHOPHARMACOLOGY
LA English
DT Meeting Abstract
CT 53rd Annual Meeting of the American-College-of-Neuropsychopharmacology
(ACNP)
CY DEC 07-11, 2014
CL Phoenix, AZ
SP Amer Coll Neuropsychopharmacol
DE Adolescence; Traumatic stress; Neuroendocrine; Behavior
C1 [Moore, Nicole; Altman, Daniel E.; Vuong, Chau V.; Sousa, Jason C.; Marcsisin, Sean R.; Zottig, Victor E.; Genovese, Raymond F.] Walter Reed Army Inst Res, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0893-133X
EI 1740-634X
J9 NEUROPSYCHOPHARMACOL
JI Neuropsychopharmacology
PD DEC
PY 2014
VL 39
SU 1
MA M34
BP S132
EP S133
PG 2
WC Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA AU9IJ
UT WOS:000345905000242
ER
PT J
AU Ghebrebrhan, M
Hoke, LC
Aranda, FJ
Hoey, ML
Archambault, DM
Perry, J
Belton, L
Ziegler, D
Carlson, JB
Kimball, BR
AF Ghebrebrhan, Michael
Hoke, Landa C.
Aranda, Francisco J.
Hoey, Megan L.
Archambault, Deana M.
Perry, Jeffrey
Belton, Lauren
Ziegler, David
Carlson, Joel B.
Kimball, Brian R.
TI Design and fabrication of extruded retroreflective polymer fibers
SO OPTICAL MATERIALS EXPRESS
LA English
DT Article
ID TEXTILES; SHAPE
AB Extruded polymer fibers with submillimeter diameters are considered for tailored optical and near-IR properties. Retroreflection of light is demonstrated. Simulated and measured reflection spectra are compared and found to agree. Additional simulations suggest that retroreflection from gold coated 12-pointed star fibers could exceed retroreflection from microbeads on t-shirt. Finally, a novel, robust, extruded retroreflective fiber with performance approaching microbeads is presented. (C) 2014 Optical Society of America
C1 [Ghebrebrhan, Michael; Hoke, Landa C.; Aranda, Francisco J.; Hoey, Megan L.; Archambault, Deana M.; Belton, Lauren; Ziegler, David; Carlson, Joel B.; Kimball, Brian R.] US Army, Fiber & Mat Phys Div, Natick Soldier Res Engn & Dev Ctr, Natick, MA 01760 USA.
[Perry, Jeffrey] US Navy, Clothing & Text Res Facil, Natick, MA 01760 USA.
RP Ghebrebrhan, M (reprint author), US Army, Fiber & Mat Phys Div, Natick Soldier Res Engn & Dev Ctr, Natick, MA 01760 USA.
EM michael.ghebrebrhan2.ctr@mail.mil
FU U.S. Army Natick Soldier Research, Development, and Engineering Center;
U.S. Department of Energy; NSRDEC
FX The authors would like to thank Alfredo Alexander-Katz, Christopher
Drew, and Betty-Ann Welsh for useful discussions. This research was
supported in part by an appointment to the Postgraduate Research
Participation Program at the U.S. Army Natick Soldier Research,
Development, and Engineering Center administered by the Oak Ridge
Institute for Science and Education through an interagency agreement
between the U.S. Department of Energy and NSRDEC.
NR 20
TC 0
Z9 0
U1 1
U2 5
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 2159-3930
J9 OPT MATER EXPRESS
JI Opt. Mater. Express
PD DEC 1
PY 2014
VL 4
IS 12
BP 2656
EP 2662
DI 10.1364/OME.4.002656
PG 7
WC Materials Science, Multidisciplinary; Optics
SC Materials Science; Optics
GA AW1EU
UT WOS:000346034100022
ER
PT J
AU Walsh, MR
Walsh, ME
Voie, OA
AF Walsh, Michael R.
Walsh, Marianne E.
Voie, Oyvind A.
TI Presence and Persistence of White Phosphorus On Military Training Ranges
SO PROPELLANTS EXPLOSIVES PYROTECHNICS
LA English
DT Article
DE White phosphorus; Residues; Persistence; Contamination; Training ranges
ID DUCKS; WATERFOWL; KESTRELS; SIZE
AB The use of obscurants is a common practice by militaries worldwide. One of the most effective of these is white phosphorus (WP). WP is the elemental form of phosphorus that does not occur in nature and is highly toxic. The use of WP rounds on training ranges has led to a number of die-offs of grazing land animals and dabbling waterfowl, the first recorded in 1930. In the 1980s, thousands of waterfowl were dying annually at an impact range in Alaska, leading to the first large-scale investigation of WP as a lethal range contaminant. Tests were conducted at an upland impact range in New York to determine the quantity and persistence of WP in a typical environment. At all sites cited in this paper, WP was persistent for months to years following the detonation of WP munitions. At the Eagle River Flats range in AK, WP was identified from rounds fired in the 1950s, persisting over 45 years in a non-saturated environment. In New York, dispersal of gram quantities of WP occurred at detonation, and high concentrations of WP were found in the detonation craters a year after firing. Caution needs to be exercised when using white phosphorus munitions on ranges.
C1 [Walsh, Michael R.; Walsh, Marianne E.] US Army Corps Engineers, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA.
[Voie, Oyvind A.] Norwegian Def Res Estab FFI, Norwegian Minist Def, N-2027 Kjeller, Norway.
RP Walsh, MR (reprint author), US Army Corps Engineers, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA.
EM Michael.Walsh@usace.army.mil
NR 36
TC 1
Z9 1
U1 1
U2 5
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY
SN 0721-3115
EI 1521-4087
J9 PROPELL EXPLOS PYROT
JI Propellants Explos. Pyrotech.
PD DEC
PY 2014
VL 39
IS 6
BP 922
EP 931
DI 10.1002/prep.201400107
PG 10
WC Chemistry, Applied; Engineering, Chemical
SC Chemistry; Engineering
GA AW1PO
UT WOS:000346062000020
ER
PT J
AU Knapik, JJ
Steelman, R
Hoedebecke, K
Rankin, S
Klug, K
Collier, K
Jones, BH
AF Knapik, Joseph J.
Steelman, Ryan
Hoedebecke, Kyle
Rankin, Shawn
Klug, Kevin
Collier, Keith
Jones, Bruce H.
TI Injury incidence with T-10 and T-11 Parachutes in Military Airborne
Operations
SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE
LA English
DT Article
DE wind; temperature; night; combat load; aircraft entanglement
ID RISK-FACTORS; ALTITUDE; SYSTEM
AB Background: The T-10 parachute has been the U.S. Army standard parachute since 1952 and is now being replaced by the T-11, which has a capacity for heavier loads. This investigation compared injury rates between the two parachute systems during mass tactical parachute training exercises at Fort Bragg, NC. Methods: Investigators were on the drop zone for all parachute operations. Data on injured jumpers were collected on the drop zone and supplemented with medical records. Operational data were collected from standard reports and weather data were obtained using a Kestrel Model 4500 pocket weather tracker. Results: There were a total of 131,747 jumps resulting in 1101 injured service members for a crude incidence of 8.4 injuries/1000 jumps. Most injuries (88%) with a known injury mechanism were associated with ground impact. In univariate analysis, risk of injury with the T-10 was 9.1/1000 jumps and that with the T-11 was 5.2/1000 jumps [odds ratio (T-10/T-11) = 1.72, 95% confidence interval (95%CI) = 1.45-2.08, P<0.011. Other factors that independently increased injury risk included night jumps, combat loads, higher wind speeds, higher temperatures, certain aircraft, and entanglements. After controlling for these factors in a multivariate analysis, injury risk was still higher for the T-10 parachute when compared to the T-11 [odds ratio (T-10/T-11) = 1.56, 95%CI = 1.28-1.89, P<0.01). For virtually all strata of the independent risk factors, the T-11 had a lower injury rate. Conclusion: Compared to the T-10, the T-11 parachute had a lower injury incidence under virtually all the operational conditions examined.
C1 US Army, Inst Publ Hlth, Aberdeen Proving Ground, MD 21010 USA.
Womack Army Med Ctr, Ft Bragg, NC USA.
Concurrent Technol Corp, Fayetteville, NC USA.
Program Management Off, Ft Belvoir, VA USA.
Oak Ridge Inst Sci & Educ, Belcamp, MD USA.
RP Knapik, JJ (reprint author), US Army, Inst Publ Hlth, ATTN MCHB IP DI, Aberdeen Proving Ground, MD 21010 USA.
EM joseph.j.knapik.ctr@mail.mil
FU Office of the Assistant Secretary of the Army (Installations, Energy and
Environment) [W74V8H-04-D-0005 Tasks 0517, 0568]
FX We would like to thank the numerous personnel from the 82nd Airborne
Division and XVIII Airborne Corps who supported this effort. These
included LTC Robert Malsby, LTC Michael Sassano, COL Michael Smith, Dr.
Ellen Segan, Mr. Tommie Brown, Mr. Earl Jefferson, CPT King Cooper, MSG
Todd Winhoven, CW3 Thompson, CW4 Lewis, Mr. Nick Weidler, Mr. Terence
Hensey, CW5 Frazier, CW3 Rojas, and SFC Jess Brown. Data collection work
was funded through the Office of the Assistant Secretary of the Army
(Installations, Energy and Environment) and conducted under contract
W74V8H-04-D-0005 Tasks 0517 and 0568. This project was supported in part
by an appointment to the Research Participation Program for the U.S.
Army Public for Health Command administered by the Oak Ridge Institute
for Science and Education through an agreement between the U.S.
Department of Energy and the USAPHC.
NR 33
TC 3
Z9 3
U1 1
U2 2
PU AEROSPACE MEDICAL ASSOC
PI ALEXANDRIA
PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA
SN 0095-6562
EI 1943-4448
J9 AVIAT SPACE ENVIR MD
JI Aviat. Space Environ. Med.
PD DEC
PY 2014
VL 85
IS 12
BP 1159
EP 1169
DI 10.3357/ASEM.4012.2014
PG 11
WC Public, Environmental & Occupational Health; Medicine, General &
Internal; Sport Sciences
SC Public, Environmental & Occupational Health; General & Internal
Medicine; Sport Sciences
GA AU8BA
UT WOS:000345820500001
PM 25479257
ER
PT J
AU Martini, AK
Rodriguez, CM
Cap, AP
Martini, WZ
Dubick, MA
AF Martini, Angela K.
Rodriguez, Cassandra M.
Cap, Andrew P.
Martini, Wenjun Z.
Dubick, Michael A.
TI Acetaminophen and meloxicam inhibit platelet aggregation and coagulation
in blood samples from humans
SO BLOOD COAGULATION & FIBRINOLYSIS
LA English
DT Article
DE and human blood; nonsteroidal anti-inflammatory drug (NSAID); platelet
aggregation; thrombelastogram
ID HEALTHY; TOLERABILITY; PARAMETERS; ASPIRIN; DISEASE; ADULTS; DOGS
AB Acetaminophen (Ace) and meloxicam (Mel) are the two types of analgesic and antipyretic medications. This study investigated the dose responses of acetaminophen and meloxicam on platelet aggregation and coagulation function in human blood samples. Blood samples were collected from six healthy humans and processed to make platelet-adjusted (100x10(3)cells/l) blood samples. Acetaminophen (Tylenol, Q-PAP, 100mg/ml) was added at the doses of 0g/ml (control), 214g/ml (the standard dose, 1x), 4x, 8x, 10x, 12x, 16x, and 20x. Similarly, meloxicam (Metacam, 5mg/ml) was added at doses of 0g/ml (control), 2.85g/ml (the standard dose, 1x), 4x, 8x, 10x, 12x, 16x, and 20x. Fifteen minutes after the addition of acetaminophen and/or meloxicam, platelet aggregation was stimulated with collagen (2g/ml) or arachidonic acid (0.5mmol/l) and assessed using a Chrono-Log 700 aggregometer. Coagulation function was assessed by prothrombin time (PT), activated partial thromboplastin time (aPTT), and using Rotem thrombelastogram. A robust inhibition by acetaminophen and/or meloxicam was observed in arachidonic acid-stimulated platelet aggregation starting at 1x dose. Collagen-stimulated platelet aggregation was inhibited by ACE starting at 1x (78 +/- 10% of control), and by meloxicam starting at 4x (72 +/- 5% of control, both P<0.05). The inhibitions by acetaminophen and meloxicam combined were similar to those by acetaminophen or meloxicam. aPTT was prolonged by meloxicam starting at 4x. No changes were observed in PT or any of Rotem measurements by acetaminophen and/or meloxicam. Acetaminophen and meloxicam compromised platelet aggregation and aPTT. Further effort is warranted to characterize the effects of acetaminophen and meloxicam on bleeding in vivo.
C1 [Martini, Angela K.] Rice Univ, Houston, TX USA.
[Rodriguez, Cassandra M.; Cap, Andrew P.; Martini, Wenjun Z.; Dubick, Michael A.] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX 78234 USA.
RP Martini, WZ (reprint author), US Army Inst Surg Res, 3698 Chambers Pass, Jbsa Ft Sam Houston, TX 78234 USA.
EM wenjun.z.martini.civ@mail.mil
FU U.S. Army Medical Research and Materiel Command
FX This study was supported by the U.S. Army Medical Research and Materiel
Command. The opinions or assertions contained herein are the private
views of the authors and are not to be construed as official or as
reflecting the views of the U. S. Department of the Army or the U. S.
Department of Defense.
NR 22
TC 0
Z9 0
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0957-5235
EI 1473-5733
J9 BLOOD COAGUL FIBRIN
JI Blood Coagul. Fibrinolysis
PD DEC
PY 2014
VL 25
IS 8
BP 831
EP 837
DI 10.1097/MBC.0000000000000162
PG 7
WC Hematology
SC Hematology
GA AT4QZ
UT WOS:000344927000009
PM 25004022
ER
PT J
AU Kasten, SA
Zulli, S
Jones, JL
Dephillipo, T
Cerasoli, DM
AF Kasten, Shane A.
Zulli, Steven
Jones, Jonathan L.
Dephillipo, Thomas
Cerasoli, Douglas M.
TI Chiral Separation of G-type Chemical Warfare Nerve Agents via Analytical
Supercritical Fluid Chromatography
SO CHIRALITY
LA English
DT Article
DE organophosphorus (OP); tabun (GA); sarin (GB); soman (GD); cyclosarin
(GF); chiral stationary phase (CSP); Regis WhelkO1
ID SWINE BLOOD-SAMPLES; 4 STEREOISOMERS; LIQUID-CHROMATOGRAPHY; ACUTE
TOXICITY; ENANTIOMERS; SOMAN; QUANTIFICATION; ATTACK; MICE
AB Chemical warfare nerve agents (CWNAs) are extremely toxic organophosphorus compounds that contain a chiral phosphorus center. Undirected synthesis of G-type CWNAs produces stereoisomers of tabun, sarin, soman, and cyclosarin (GA, GB, GD, and GF, respectively). Analytical-scale methods were developed using a supercritical fluid chromatography (SFC) system in tandem with a mass spectrometer for the separation, quantitation, and isolation of individual stereoisomers of GA, GB, GD, and GF. Screening various chiral stationary phases (CSPs) for the capacity to provide full baseline separation of the CWNAs revealed that a Regis WhelkO1 (SS) column was capable of separating the enantiomers of GA, GB, and GF, with elution of the P(+) enantiomer preceding elution of the corresponding P(-) enantiomer; two WhelkO1 (SS) columns had to be connected in series to achieve complete baseline resolution. The four diastereomers of GD were also resolved using two tandem WhelkO1 (SS) columns, with complete baseline separation of the two P(+) epimers. A single WhelkO1 (RR) column with inverse stereochemistry resulted in baseline separation of the GD P(-) epimers. The analytical methods described can be scaled to allow isolation of individual stereoisomers to assist in screening and development of countermeasures to organophosphorus nerve agents. Chirality 26:817-824, 2014. (c) 2014 The Authors. Chirality published by John Wiley Periodicals, Inc.
C1 [Kasten, Shane A.; Cerasoli, Douglas M.] US Army, Med Res Inst Chem Def, Div Res, Physiol & Immunol Branch, Aberdeen Proving Ground, MD 21010 USA.
[Zulli, Steven; Jones, Jonathan L.] Waters Corp, New Castle, DE USA.
[Dephillipo, Thomas] Waters Corp, Milford, MA USA.
RP Kasten, SA (reprint author), US Army, Med Res Inst Chem Def, Div Res, Physiol & Immunol Branch, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA.
EM shane.a.kasten.ctr@mail.mil; douglas.m.cerasoli.civ@mail.mil
FU Defense Threat Reduction Agency-Joint Science and Technology Office,
Medical ST Division; U.S. Department of Energy; USAMRICD
FX We would like to thank John Richard Smith for insightful discussions on
chiral analysis, for kindly sharing reagents, and for previously
establishing initial conditions for chiral separations of CWNAs at the
USAMRICD. We also thank Jon Oyler, USAMRICD, for thoughtful discussion
and review of this manuscript. Also we thank Dan Rolle and Lakshmi
Subbarao from Waters Corporation for technical assistance important for
making this study possible. This work was supported by the Defense
Threat Reduction Agency-Joint Science and Technology Office, Medical S&T
Division. S.A.K. was supported in part by an appointment to the
Internship/Research Participation Program for the U.S. Army Medical
Research Institute of Chemical Defense, administered by the Oak Ridge
Institute for Science and Education through an agreement between the
U.S. Department of Energy and the USAMRICD. The views expressed in this
article are those of the author(s) and do not reflect the official
policy of the Department of Army, Department of Defense, or the U.S.
Government.
NR 19
TC 2
Z9 2
U1 4
U2 27
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0899-0042
EI 1520-636X
J9 CHIRALITY
JI Chirality
PD DEC
PY 2014
VL 26
IS 12
BP 817
EP 824
DI 10.1002/chir.22368
PG 8
WC Chemistry, Medicinal; Chemistry, Analytical; Chemistry, Organic;
Pharmacology & Pharmacy
SC Pharmacology & Pharmacy; Chemistry
GA AU5EO
UT WOS:000345630200009
PM 25298066
ER
PT J
AU Flores, M
Longnecker, M
Tomberlin, JK
AF Flores, Micah
Longnecker, Michael
Tomberlin, Jeffery K.
TI Effects of temperature and tissue type on Chrysomya rufifacies (Diptera:
Calliphoridae) (Macquart) development
SO FORENSIC SCIENCE INTERNATIONAL
LA English
DT Article
DE Hairy maggot; Blow fly; Forensic entomology; Phenotypic plasticity
ID COCHLIOMYIA-MACELLARIA DIPTERA; LUCILIA-SERICATA DIPTERA; PHORMIA-REGINA
DIPTERA; DIFFERENT BODY-TISSUES; FORENSIC ENTOMOLOGY; BLOW FLIES; RATES;
POPULATION; LARVAE; FLY
AB The hairy maggot blow fly, Chrysomya rufifacies (Diptera: Calliphoridae), is a forensically important fly often encountered on human and other vertebrate remains in temperate and tropic regions throughout the world including Australia, Asia, Central America and North America. C. rufifacies was reared under controlled laboratory conditions on three muscle types (i.e., porcine, equine and canine) at three temperatures (i. e., 20.8, 24.8 and 28.3 degrees C). Rate of larval weight gain across time was statistically significant between muscle types (P <= 0.0001) and approaching significance across time between temperatures (P = 0.0511). This research represents the first development study for C. rufifacies from central Texas, USA and the first study to examine the impact of tissue type on its development. Furthermore, these data, when compared to those available in the literature, indicate developmental differences that could be due to genetic differences in populations or possibly methods employed during the studies. Caution should be emphasized when applying development data for this species from one region to forensic investigations in other ecoregions as such differences in development based on tissue fed upon by larvae, population genetics, and methodologies used in the studies could represent error in estimating the time of colonization. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [Flores, Micah; Tomberlin, Jeffery K.] Texas A&M Univ, Dept Entomol, College Stn, TX 77843 USA.
[Longnecker, Michael] Texas A&M Univ, Dept Stat, College Stn, TX 77843 USA.
[Flores, Micah] Walter Reed Army Inst Res, Bacterial & Rickettsial Dept, Silver Spring, MD USA.
RP Flores, M (reprint author), Texas A&M Univ, Dept Entomol, 2475 TAMU, College Stn, TX 77843 USA.
EM chrysomicah@gmail.com
FU Agrilife Research; Department of Entomology; J.H. Benedict, Sr. Memorial
Scholarship
FX MF and JKT would like to thank Agrilife Research and the Department of
Entomology for providing partial financial support for this study.
Additionally we would like to thank the J.H. Benedict, Sr. Memorial
Scholarship for support during this research. They would also like to
thank Aaron M. Tarone and two anonymous reviewers for comments on
earlier drafts of this manuscript.
NR 37
TC 9
Z9 10
U1 3
U2 52
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0379-0738
EI 1872-6283
J9 FORENSIC SCI INT
JI Forensic Sci.Int.
PD DEC
PY 2014
VL 245
BP 24
EP 29
DI 10.1016/j.forsciint.2014.09.023
PG 6
WC Medicine, Legal
SC Legal Medicine
GA AU5DT
UT WOS:000345628100015
PM 25447170
ER
PT J
AU Drake, DL
Anderson, TL
Smith, LM
Lohraff, KM
Semlitsch, RD
AF Drake, Dana L.
Anderson, Thomas L.
Smith, Lauren M.
Lohraff, Kenton M.
Semlitsch, Raymond D.
TI PREDATION OF EGGS AND RECENTLY HATCHED LARVAE OF ENDEMIC RINGED
SALAMANDERS (AMBYSTOMA ANNULATUM) BY NATIVE AND INTRODUCED AQUATIC
PREDATORS
SO HERPETOLOGICA
LA English
DT Article
DE Amphibians; Community structure; Food choice; Hatchlings; Management;
Palatability; Refuge; Survival
ID MOSQUITOFISH GAMBUSIA-AFFINIS; NOTOPHTHALMUS-VIRIDESCENS; EXPERIMENTAL
WETLANDS; HABITAT COMPLEXITY; PREY INTERACTIONS; POND COMMUNITIES;
AMPHIBIAN LARVAE; FISH PREDATION; TADPOLES; SIZE
AB Predation is a key determinant of pond community structure, yet not all predators are equally effective and not all life stages of potential prey are similarly susceptible. Understanding the effects of native and introduced species is essential to informing management strategies, especially for endemic and species of conservation concern. We examined the effects of five common predators (three native: Central Newts [Notophthalmus viridescens louisianensis], aeshnid dragonfly naiads [Aeshnidae], and Southern Leopard Frog tadpoles [Lithobates sphenocephalus]; and two introduced: Fathead Minnows [Pimephales promelas] and Mosquitofish [Gambusia affinis]) on survival of eggs and recently hatched larvae of Ringed Salamanders (Ambystoma annulatum). We also examined the effect of supplemental food or cover availability on survival at each stage. Predators primarily showed a binary response to eggs, consuming all or none of them. Supplemental food did not influence whether eggs or larvae were consumed. Larvae were consumed by all predator species although the effect varied. The presence of cover did not reduce the impacts of the other predators on larval survival. Overall, the two introduced fish species had a greater impact on survival of the early stages of Ringed Salamanders than did the native predators. Further inquiries into the susceptibility of different life stages and survival will improve conservation strategies for rare and endemic species such as Ringed Salamanders.
C1 [Drake, Dana L.; Anderson, Thomas L.; Smith, Lauren M.; Semlitsch, Raymond D.] Univ Missouri, Div Biol Sci, Columbia, MO 65211 USA.
[Lohraff, Kenton M.] US Army, IMCOM, Ft Leonard Wood, MO 65473 USA.
[Lohraff, Kenton M.] US Army, FLW, DPW Nat Resources Branch, Ft Leonard Wood, MO 65473 USA.
RP Drake, DL (reprint author), Univ Missouri, Div Biol Sci, 105 Tucker Hall, Columbia, MO 65211 USA.
EM drake.dana.l@gmail.com
OI Semlitsch, Raymond/0000-0002-7999-5762
FU Department of Defense Strategic Environmental Research Development
Program [RC2155]
FX We thank J. Robinson and S. Politte for assistance with laboratory setup
and data collection. This research was approved by the University of
Missouri Animal Care and Use Committee (Protocol no. 7403), collections
were made under Missouri Department of Conservation Research Permit (no.
15562), and it was supported by the Department of Defense Strategic
Environmental Research Development Program (Award no. RC2155).
NR 50
TC 8
Z9 8
U1 4
U2 38
PU HERPETOLOGISTS LEAGUE
PI EMPORIA
PA EMPORIA STATE UNIV, DIVISION BIOLOGICAL SCIENCES, 1200 COMMERCIAL ST,
EMPORIA, KS 66801-5087 USA
SN 0018-0831
EI 1938-5099
J9 HERPETOLOGICA
JI Herpetologica
PD DEC
PY 2014
VL 70
IS 4
BP 378
EP 387
PG 10
WC Zoology
SC Zoology
GA AU8HS
UT WOS:000345837900002
ER
PT J
AU Rakesh, V
Stallings, JD
Reifman, J
AF Rakesh, Vineet
Stallings, Jonathan D.
Reifman, Jaques
TI A virtual rat for simulating environmental and exertional heat stress
SO JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Article
DE three-dimensional computational rat model; heat transfer; core
temperature circadian rhythm; organ-specific response; whole body
cooling
ID BODY-TEMPERATURE; STROKE; EXERCISE; HEATSTROKE; BRAIN; GHZ
AB Severe cases of environmental or exertional heat stress can lead to varying degrees of organ dysfunction. To understand heat-injury progression and develop efficient management and mitigation strategies, it is critical to determine the thermal response in susceptible organs under different heat-stress conditions. To this end, we used our previously published virtual rat, which is capable of computing the spatiotemporal temperature distribution in the animal, and extended it to simulate various heat-stress scenarios, including 1) different environmental conditions, 2) exertional heat stress, 3) circadian rhythm effect on the thermal response, and 4) whole body cooling. Our predictions were consistent with published in vivo temperature measurements for all cases, validating our simulations. We observed a differential thermal response in the organs, with the liver experiencing the highest temperatures for all environmental and exertional heat-stress cases. For every 3 degrees C rise in the external temperature from 40 to 46 degrees C, core and organ temperatures increased by similar to 0.8 degrees C. Core temperatures increased by 2.6 and 4.1 degrees C for increases in exercise intensity from rest to 75 and 100% of maximal O-2 consumption, respectively. We also found differences as large as 0.8 degrees C in organ temperatures for the same heat stress induced at different times during the day. Even after whole body cooling at a relatively low external temperature (1 degrees C for 20 min), average organ temperatures were still elevated by 2.3 to 2.5 degrees C compared with normothermia. These results can be used to optimize experimental protocol designs, reduce the amount of animal experimentation, and design and test improved heat-stress prevention and management strategies.
C1 [Rakesh, Vineet; Reifman, Jaques] US Army Med Res & Mat Command, MCMR TT, Telemed & Adv Technol Res Ctr, Dept Def,Biotechnol High Performance Comp Softwar, Ft Detrick, MD 21702 USA.
[Stallings, Jonathan D.] US Army Ctr Environm Hlth Res, Environm Hlth Program, Ft Detrick, MD USA.
RP Reifman, J (reprint author), US Army Med Res & Mat Command, MCMR TT, Telemed & Adv Technol Res Ctr, Dept Def,Biotechnol High Performance Comp Softwar, 504 Scott St, Ft Detrick, MD 21702 USA.
EM jaques.reifman.civ@mail.mil
OI Stallings, Jonathan/0000-0002-6430-5888
FU U.S. Army Network Science Initiative; Military Operational Medicine
Research Program, U.S. Army Medical Research and Materiel Command, Fort
Detrick, MD
FX The research was supported by the U.S. Army Network Science Initiative
and the Military Operational Medicine Research Program, U.S. Army
Medical Research and Materiel Command, Fort Detrick, MD.
NR 27
TC 1
Z9 2
U1 1
U2 6
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 8750-7587
EI 1522-1601
J9 J APPL PHYSIOL
JI J. Appl. Physiol.
PD DEC 1
PY 2014
VL 117
IS 11
BP 1278
EP 1286
DI 10.1152/japplphysiol.00614.2014
PG 9
WC Physiology; Sport Sciences
SC Physiology; Sport Sciences
GA AW0ZZ
UT WOS:000346021300006
PM 25277741
ER
PT J
AU Stewart, CL
Mulligan, J
Grudic, GZ
Convertino, VA
Moulton, SL
AF Stewart, Camille L.
Mulligan, Jane
Grudic, Greg Z.
Convertino, Victor A.
Moulton, Steven L.
TI Detection of low-volume blood loss: Compensatory reserve versus
traditional vital signs
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article; Proceedings Paper
CT 44th Annual Meeting of the Western-Trauma-Association
CY MAR 02-07, 2014
CL Steamboat Springs, CO
SP Western Trauma Assoc
DE Machine learning; compensatory reserve index; photoplethysmogram; acute
blood loss
ID BODY NEGATIVE-PRESSURE; PLETH VARIABILITY INDEX; FLUID RESPONSIVENESS;
BASE DEFICIT; CENTRAL HYPOVOLEMIA; TRAUMA PATIENTS; EARLY-DIAGNOSIS;
SHOCK; HEMORRHAGE; THERAPY
AB BACKGROUND: Humans are able to compensate for low-volume blood loss with minimal change in traditional vital signs. We hypothesized that a novel algorithm, which analyzes photoplethysmogram (PPG) wave forms to continuously estimate compensatory reserve would provide greater sensitivity and specificity to detect low-volume blood loss compared with traditional vital signs. The compensatory reserve index (CRI) is a measure of the reserve remaining to compensate for reduced central blood volume, where a CRI of 1 represents supine normovolemia and 0 represents the circulating blood volume at which hemodynamic decompensation occurs; values between 1 and 0 indicate the proportion of reserve remaining.
METHODS: Subjects underwent voluntary donation of 1 U (approximately 450 mL) of blood. Demographic and continuous noninvasive vital sign wave form data were collected, including PPG, heart rate, systolic blood pressure, cardiac output, and stroke volume. PPG wave forms were later processed by the algorithm to estimate CRI values.
RESULTS: Data were collected from 244 healthy subjects (79 males and 165 females), with a mean (SD) age of 40.1 (14.2) years and mean (SD) body mass index of 25.6 (4.7). After blood donation, CRI significantly decreased in 92% (alpha = 0.05; 95% confidence interval [CI], 88-95%) of the subjects. With the use of a threshold decrease in CRI of 0.05 or greater for the detection of 1 U of blood loss, the receiver operating characteristic area under the curve was 0.90, with a sensitivity of 0.84 and specificity of 0.86. In comparison, systolic blood pressure (52%; 95% CI, 45-59%), heart rate (65%; 95% CI, 58-72%), cardiac output (47%; 95% CI, 40-54%), and stroke volume (74%; 95% CI, 67-80%) changed in fewer subjects, had significantly lower receiver operating characteristic area under the curve values, and significantly lower specificities for detecting the same volume of blood loss.
CONCLUSION: Consistent with our hypothesis, CRI detected low-volume blood loss with significantly greater specificity than other traditional physiologic measures. These findings warrant further evaluation of the CRI algorithm in actual trauma settings. (Copyright 0 2014 by Lippincott Williams & Wilkins)
C1 [Stewart, Camille L.; Moulton, Steven L.] Univ Colorado, Dept Surg, Sch Med, Boulder, CO 80309 USA.
[Mulligan, Jane; Grudic, Greg Z.; Moulton, Steven L.] Flashback Technol Inc, Boulder, CO USA.
[Moulton, Steven L.] Childrens Hosp Colorado, Div Pediat Surg, Aurora, CO 80045 USA.
[Convertino, Victor A.] US Army Inst Surg Res, San Antonio, TX USA.
RP Moulton, SL (reprint author), Childrens Hosp Colorado, B-323,13123 E 16th Ave, Aurora, CO 80045 USA.
EM Steven.moulton@childrenscolorado.org
NR 40
TC 11
Z9 11
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 2163-0755
EI 2163-0763
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD DEC
PY 2014
VL 77
IS 6
BP 892
EP 897
DI 10.1097/TA.0000000000000423
PG 6
WC Critical Care Medicine; Surgery
SC General & Internal Medicine; Surgery
GA AU8EE
UT WOS:000345828500023
PM 25423536
ER
PT J
AU Xia, FN
Wang, H
Xiao, D
Dubey, M
Ramasubramaniam, A
AF Xia, Fengnian
Wang, Han
Xiao, Di
Dubey, Madan
Ramasubramaniam, Ashwin
TI Two-dimensional material nanophotonics
SO NATURE PHOTONICS
LA English
DT Review
ID ULTRAFAST GRAPHENE PHOTODETECTOR; TRANSITION-METAL DICHALCOGENIDES;
LIGHT-MATTER INTERACTIONS; FIELD-EFFECT TRANSISTORS; LAYER BLACK
PHOSPHORUS; ATOMICALLY THIN MOS2; PHOTOCURRENT GENERATION; VALLEY
POLARIZATION; ELECTRICAL CONTROL; HIGH-RESPONSIVITY
AB Two-dimensional materials exhibit diverse electronic properties, ranging from insulating hexagonal boron nitride and semiconducting transition metal dichalcogenides such as molybdenum disulphide, to semimetallic graphene. In this Review, we first discuss the optical properties and applications of various two-dimensional materials, and then cover two different approaches for enhancing their interactions with light: through their integration with external photonic structures, and through intrinsic polaritonic resonances. Finally, we present a narrow-bandgap layered material - black phosphorus - that serendipitously bridges the energy gap between the zero-bandgap graphene and the relatively large-bandgap transition metal dichalcogenides. The plethora of two-dimensional materials and their heterostructures, together with the array of available approaches for enhancing the light-matter interaction, offers the promise of scientific discoveries and nanophotonics technologies across a wide range of the electromagnetic spectrum.
C1 [Xia, Fengnian] Yale Univ, Dept Elect Engn, New Haven, CT 06511 USA.
[Wang, Han] Univ So Calif, Ming Hsieh Dept Elect Engn, Los Angeles, CA 90089 USA.
[Xiao, Di] Carnegie Mellon Univ, Dept Phys, Pittsburgh, PA 15213 USA.
[Dubey, Madan] Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
[Ramasubramaniam, Ashwin] Univ Massachusetts, Dept Mech & Ind Engn, Amherst, MA 01003 USA.
RP Xia, FN (reprint author), Yale Univ, Dept Elect Engn, 15 Prospect St, New Haven, CT 06511 USA.
EM fengnian.xia@yale.edu
RI Xiao, Di/B-1830-2008; Ramasubramaniam, Ashwin/A-4608-2009; Xia,
Fengnian/O-2637-2015
OI Xiao, Di/0000-0003-0165-6848; Ramasubramaniam,
Ashwin/0000-0001-6595-7442; Xia, Fengnian/0000-0001-5176-368X
FU Office of Naval Research [N00014-14-1-0565]; Air Force Office of
Scientific Research [FA9550-14-1-0277]; National Science Foundation
(CRISP NSF MRSEC) [DMR-1119826]; Army Research Laboratory
[W911NF-14-2-0113]; Department of Energy [SC0012509]; National Science
Foundation [EFRI-1433496]
FX We thank X. Xu at the University of Washington, Seattle and M.
Dresselhaus at Massachusetts Institute of Technology for insightful
comments. We would also like to thank T. Low at the University of
Minnesota for his input at the early stage of this project and L. Wang
at the University of Southern California for designing Fig. 6c,d. F.X.
acknowledges support from the Office of Naval Research
(N00014-14-1-0565), the Air Force Office of Scientific Research
(FA9550-14-1-0277) and the National Science Foundation (CRISP NSF MRSEC
DMR-1119826). H.W. acknowledges support from the Army Research
Laboratory (W911NF-14-2-0113). D.X. acknowledges support from the
Department of Energy (SC0012509), the Air Force Office of Scientific
Research (FA9550-14-1-0277), and the National Science Foundation
(EFRI-1433496).
NR 97
TC 295
Z9 297
U1 140
U2 788
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-4885
EI 1749-4893
J9 NAT PHOTONICS
JI Nat. Photonics
PD DEC
PY 2014
VL 8
IS 12
BP 899
EP 907
DI 10.1038/NPHOTON.2010.271
PG 9
WC Optics; Physics, Applied
SC Optics; Physics
GA AU8AG
UT WOS:000345818600008
ER
PT J
AU Phillips, BN
Chun, D
Barnes, SD
AF Phillips, Brandon N.
Chun, Dal
Barnes, Scott D.
TI Untitled Reply
SO RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
LA English
DT Letter
C1 [Phillips, Brandon N.; Barnes, Scott D.] Womack Army Med Ctr, Ophthalmol Serv, Ft Bragg, NC 28307 USA.
[Chun, Dal] Retina Grp Washington, Washington, DC USA.
RP Phillips, BN (reprint author), Womack Army Med Ctr, Ophthalmol Serv, Ft Bragg, NC 28307 USA.
NR 2
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0275-004X
EI 1539-2864
J9 RETINA-J RET VIT DIS
JI Retin.-J. Retin. Vitr. Dis.
PD DEC
PY 2014
VL 34
IS 12
BP E41
EP E41
PG 1
WC Ophthalmology
SC Ophthalmology
GA AU9KK
UT WOS:000345911300003
PM 25407236
ER
PT J
AU Kim, S
Bedigrew, K
Guda, T
Maloney, WJ
Park, S
Wenke, JC
Yang, YP
AF Kim, Sungwoo
Bedigrew, Katherine
Guda, Teja
Maloney, William J.
Park, Sangwon
Wenke, Joseph C.
Yang, Yunzhi Peter
TI Novel osteoinductive photo-cross-linkable chitosan-lactide-fibrinogen
hydrogels enhance bone regeneration in critical size segmental bone
defects
SO ACTA BIOMATERIALIA
LA English
DT Article
DE Chitosan; Lactide; Fibrinogen; Photo-cross-linkable hydrogel; BMP-2
ID HEPARIN-BINDING DOMAIN; MORPHOGENETIC PROTEIN-2; GROWTH-FACTORS;
CONTROLLED-RELEASE; IN-VITRO; DELIVERY; BMP-2; MATRIX; REPAIR;
DEGRADATION
AB The purpose of this study was to develop and characterize a novel photo-cross-linkable chitosan-lactide-fibrinogen (CLF) hydrogel and evaluate the efficacy of bone morphogenetic protein-2 (BMP-2) containing a CLF hydrogel for osteogenesis in vitro and in vivo. We synthesized the CLF hydrogels and characterized their chemical structure, degradation rate, compressive modulus and in vitro BMP-2 release kinetics. We evaluated bioactivities of the BMP-2 containing CLF hydrogels (0, 50, 100 and 500 ng ml(-1)) in vitro using W-20-17 preosteoblast mouse bone marrow stromal cells and C2C12 mouse myoblast cells. The effect of BMP-2 containing CLF gels (0, 0.5, 1, 2 and 5 mu g) on bone formation was evaluated using rat critical size segmental bone defects for 4 weeks. Fourier transform infrared spectroscopy spectra and scanning electron microscopy images showed chemical and structural changes by the addition of fibrinogen into the chitosan-lactide copolymer. The incorporation of fibrinogen molecules significantly increased the compressive modulus of the hydrogels. The in vitro BMP-2 release study showed initial burst releases from the CLF hydrogels followed by sustained releases, regardless of the concentration of the BMP-2 over 4 weeks. Cells in all groups were viable in the presence of the hydrogels regardless of BMP-2 doses, indicating non-cytotoxicity of hydrogels. Alkaline phosphate activity and mineralization of cells exhibited dose dependence on BMP-2 containing CLF hydrogels. Radiography, microcomputed tomography and histology confirmed that the BMP-2 containing CLF hydrogels prompted neo-osteogenesis and accelerated healing of the defects in a dose-dependent manner. Thus the CLF hydrogel is a promising delivery system of growth factors for bone regeneration. (C) 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
C1 [Kim, Sungwoo; Maloney, William J.; Yang, Yunzhi Peter] Stanford Univ, Dept Orthoped Surg, Stanford, CA 94305 USA.
[Bedigrew, Katherine; Wenke, Joseph C.] US Army, Extrem Trauma & Regenerat Med Task Area, Inst Surg Res, San Antonio, TX USA.
[Guda, Teja] US Army, Dept Craniomaxillofacial Regenerat Med Dent & Tra, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Park, Sangwon] Chonnam Natl Univ, Sch Dent, Dept Prosthodont, Dent Sci Res Inst, Kwangju, South Korea.
[Park, Sangwon] Chonnam Natl Univ, Sch Dent, Project BK21, Kwangju, South Korea.
[Yang, Yunzhi Peter] Stanford Univ, Dept Mat Sci & Engn, Stanford, CA 94305 USA.
RP Yang, YP (reprint author), Stanford Univ, Dept Orthoped Surg, Stanford, CA 94305 USA.
EM ypyang@stanford.edu
FU DOD [W81XWH-10-1-0966]; Airlift Research Foundation; Wallace H. Coulter
Foundation; NIH from NIAMS [R01AR057837]; NIH from NIDCR [R01DE021468]
FX We acknowledge the grant supports from DOD W81XWH-10-1-0966, Airlift
Research Foundation, Wallace H. Coulter Foundation, NIH R01AR057837 from
NIAMS and NIH R01DE021468 from NIDCR.
NR 49
TC 9
Z9 10
U1 7
U2 41
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1742-7061
EI 1878-7568
J9 ACTA BIOMATER
JI Acta Biomater.
PD DEC
PY 2014
VL 10
IS 12
BP 5021
EP 5033
DI 10.1016/j.actbio.2014.08.028
PG 13
WC Engineering, Biomedical; Materials Science, Biomaterials
SC Engineering; Materials Science
GA AU2SQ
UT WOS:000345468300011
PM 25174669
ER
PT J
AU Dickens, JF
Owens, BD
Cameron, KL
Kilcoyne, K
Allred, CD
Svoboda, SJ
Sullivan, R
Tokish, JM
Peck, KY
Rue, JP
AF Dickens, Jonathan F.
Owens, Brett D.
Cameron, Kenneth L.
Kilcoyne, Kelly
Allred, C. Dain
Svoboda, Steven J.
Sullivan, Robert
Tokish, John M.
Peck, Karen Y.
Rue, John-Paul
TI Return to Play and Recurrent Instability After In-Season Anterior
Shoulder Instability A Prospective Multicenter Study
SO AMERICAN JOURNAL OF SPORTS MEDICINE
LA English
DT Article
DE glenohumeral; anterior instability; in season; return
ID ARTHROSCOPIC BANKART REPAIR; FOLLOW-UP; NONOPERATIVE TREATMENT; INDEX
WOSI; DISLOCATION; MANAGEMENT; STABILIZATION; 1ST-TIME; LESIONS; YOUNG
AB Background: There is no consensus on the optimal treatment of in-season athletes with anterior shoulder instability, and limited data are available to guide return to play.
Purpose: To examine the likelihood of return to sport and the recurrence of instability after an in-season anterior shoulder instability event based on the type of instability (subluxation vs dislocation). Additionally, injury factors and patient-reported outcome scores administered at the time of injury were evaluated to assess the predictability of eventual successful return to sport and time to return to sport during the competitive season.
Study Design: Cohort study (prognosis); Level of evidence, 2.
Methods: Over 2 academic years, 45 contact intercollegiate athletes were prospectively enrolled in a multicenter observational study to assess return to play after in-season anterior glenohumeral instability. Baseline data collection included shoulder injury characteristics and shoulder-specific patient-reported outcome scores at the time of injury. All athletes underwent an accelerated rehabilitation program without shoulder immobilization and were followed during their competitive season to assess the success of return to play and recurrent instability.
Results: Thirty-three of 45 (73%) athletes returned to sport for either all or part of the season after a median 5 days lost from competition (interquartile range, 13). Twelve athletes (27%) successfully completed the season without recurrence. Twenty-one athletes (64%) returned to in-season play and had subsequent recurrent instability including 11 recurrent dislocations and 10 recurrent subluxations. Of the 33 athletes returning to in-season sport after an instability event, 67% (22/33) completed the season. Athletes with a subluxation were 5.3 times more likely (odds ratio [OR], 5.32; 95% CI, 1.00-28.07; P = .049) to return to sport during the same season when compared with those with dislocations. Logistic regression analysis suggests that the Western Ontario Shoulder Instability Index (OR, 1.05; 95% CI, 1.00-1.09; P = .037) and Simple Shoulder Test (OR, 1.03; 95% CI, 1.00-1.05; P = .044) administered after the initial instability event are predictive of the ability to return to play. Time loss from sport after a shoulder instability event was most strongly and inversely correlated with the Simple Shoulder Test (P = .007) at the time of initial injury.
Conclusion: In the largest prospective study evaluating shoulder instability in in-season contact athletes, 27% of athletes returned to play and completed the season without subsequent instability. While the majority of athletes who return to sport complete the season, recurrent instability events are common regardless of whether the initial injury was a subluxation or dislocation.
C1 US Naval Acad, Annapolis, MD 21402 USA.
US Mil Acad, West Point, NY 10996 USA.
US Air Force Acad, Colorado Springs, CO 80840 USA.
RP Dickens, JF (reprint author), US Mil Acad, Keller Army Hosp, 3328 East Continental Rd, West Point, NY 10996 USA.
EM jon.f.dickens@gmail.com
OI Cameron, Kenneth/0000-0002-6276-4482
NR 46
TC 15
Z9 15
U1 0
U2 12
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0363-5465
EI 1552-3365
J9 AM J SPORT MED
JI Am. J. Sports Med.
PD DEC
PY 2014
VL 42
IS 12
BP 2842
EP 2850
DI 10.1177/0363546514553181
PG 9
WC Orthopedics; Sport Sciences
SC Orthopedics; Sport Sciences
GA AU4SA
UT WOS:000345600600007
PM 25378207
ER
PT J
AU Brenner, MW
Boddu, VM
Kumar, A
AF Brenner, Matthew W.
Boddu, Veera M.
Kumar, Ashok
TI Control of morphology for energy dissipation in carbon nanotube forests
SO APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
LA English
DT Article
ID SOURCE GASES; GROWTH; COMPOSITES; ARRAYS; WIRES; TIPS
AB This study focuses on the effect of carbon precursor on the carbon nanotube (CNT) morphology and energy dissipation. Benzene, toluene, and m-xylene were used as carbon precursors for the synthesis of CNT forests following a chemical vapor deposition process. The results indicate that substituents on the benzene ring increase entanglement in the CNT forests. The absorbed energy was slightly greater for CNT forests synthesized using m-xylene than for toluene, but was much smaller for benzene. When compressed to a strain of 0.67, the toluene CNTs absorbed more energy than the m-xylene CNTs. The restitution was much higher for the forests synthesized with m-xylene than toluene while it further decreased for the forests made with benzene. A strong correlation is also observed between the average diameter of the CNTs and the number of methyl substituents on the benzene ring. The control of the entanglement of the CNT forests can potentially be used to design high energy absorbing composites for blast energy dissipation.
C1 [Brenner, Matthew W.; Boddu, Veera M.; Kumar, Ashok] US Army Engn Res & Dev Ctr, Environm Proc Branch, Construct Engn Res Lab ERDC CERL, Champaign, IL 61826 USA.
RP Boddu, VM (reprint author), US Army Engn Res & Dev Ctr, Environm Proc Branch, Construct Engn Res Lab ERDC CERL, Champaign, IL 61826 USA.
EM Veera.Boddu@usace.army.mil
FU U.S. Department of Energy; ERDC-CERL
FX This research was supported in part by an appointment to the
Postgraduate Research Participation Program at the U.S. Army Engineer
Research and Development Center, Construction Engineering Research
Laboratory (ERDC-CERL) administered by the Oak Ridge Institute for
Science and Education through an interagency agreement between the U.S.
Department of Energy and ERDC-CERL.
NR 33
TC 2
Z9 2
U1 1
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0947-8396
EI 1432-0630
J9 APPL PHYS A-MATER
JI Appl. Phys. A-Mater. Sci. Process.
PD DEC
PY 2014
VL 117
IS 4
BP 1849
EP 1857
DI 10.1007/s00339-014-8812-6
PG 9
WC Materials Science, Multidisciplinary; Physics, Applied
SC Materials Science; Physics
GA AU0DI
UT WOS:000345293200026
ER
PT J
AU Shields, BA
Brown, JN
Aden, JK
Salgueiro, M
Mann-Salinas, EA
Chung, KK
AF Shields, Beth A.
Brown, Jennifer N.
Aden, James K.
Salgueiro, Marybeth
Mann-Salinas, Elizabeth A.
Chung, Kevin K.
TI A pilot review of gradual versus goal re-initiation of enteral nutrition
after burn surgery in the hemodynamically stable patient
SO BURNS
LA English
DT Article
DE Enteral; Burn; Nutrition; Surgery; Calorie
ID RESTING ENERGY-EXPENDITURE; CRITICALLY-ILL PATIENTS; PROVISION;
PROTOCOL; IMMEDIATE; EFFICACY; TRIAL; ROUTE
AB Severe weight loss resulting from inadequate nutritional intake along with the hypermetabolism after thermal injury can result in impaired immune function and delayed wound healing. This observational study was conducted on adults admitted between October 2007 and April 2012 with at least 20% total body surface area burn requiring excision who previously tolerated gastric enteral nutrition at calorie goal and who returned from surgery hemodynamically stable (no new pressor requirement) and compared the effect of goal rate re-initiation versus slow re-initiation after the first excision and grafting. Demographic, intake, and tolerance data were collected during the 36 h following surgery and were analyzed with descriptive and comparative statistics. Data were collected on 14 subjects who met the inclusion criteria. Subjects in the goal rate re-initiation group (n = 7) met a significantly greater percentage of caloric goals (99 +/- 12% versus 58 +/- 21%, p = 0.003) during the 36 h following surgery than subjects in the slow re-initiation group (n = 7). There were no incidences of emesis, aspiration, or ischemic bowel in either group. The goal rate reinitiation group had a 29% incidence of either stool output > 1 L (n = 1) or gastric residual volumes > 500 mL (n = 1), whereas these were not present in the slow re-initiation group (p = 0.462). In conclusion, in this small pilot study, we found that enteral nutrition could be re-initiated after the first excision and grafting in those patients who previously tolerated gastric enteral nutrition meeting caloric goals who return from surgery hemodynamically stable without a significant difference in intolerance and with a significantly higher percentage of calorie goals achieved, but larger studies are required. Published by Elsevier Ltd and ISBI.
C1 [Shields, Beth A.; Brown, Jennifer N.; Salgueiro, Marybeth] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA.
[Aden, James K.; Mann-Salinas, Elizabeth A.; Chung, Kevin K.] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Chung, Kevin K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
RP Shields, BA (reprint author), US Army Inst Surg Res, Burn Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM beth.shields@us.army.mil
FU U.S. Army Institute of Surgical Research
FX The Clinical Trials in Burns and Trauma Task Area and the U.S. Army
Institute of Surgical Research.
NR 21
TC 0
Z9 0
U1 1
U2 5
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0305-4179
EI 1879-1409
J9 BURNS
JI Burns
PD DEC
PY 2014
VL 40
IS 8
BP 1587
EP 1592
DI 10.1016/j.burns.2014.02.015
PG 6
WC Critical Care Medicine; Dermatology; Surgery
SC General & Internal Medicine; Dermatology; Surgery
GA AU1ER
UT WOS:000345364400027
PM 24997527
ER
PT J
AU Mitchell, TA
Hardin, MO
Murray, CK
Ritchie, JD
Cancio, LC
Renz, EM
White, CE
AF Mitchell, Thomas A.
Hardin, Mark O.
Murray, Clinton K.
Ritchie, John D.
Cancio, Leopoldo C.
Renz, Evan M.
White, Christopher E.
TI Mucormycosis attributed mortality: A seven-year review of surgical and
medical management
SO BURNS
LA English
DT Article
DE Mucormycosis; Fungal wound infection; Fungal wound colonization; Trauma;
Combat; Amputation; War
ID BURN WOUND-INFECTION; FUNGAL-INFECTION; COLONIZATION
AB Introduction: Historically, mucormycosis infections have been associated with high mortality. The purpose of this study was to determine the incidence, associated mortality, and management strategies of mucormycosis in a major burn center.
Methods: A retrospective review was performed via obtaining all patients with mucormycosis admitted from January 2003 to November 2009 at our adult burn center was performed obtaining demographic data relevant to fungal burn wound infection or colonization.
Results: The incidence of mucormycosis at our facility was 4.9 per 1000 admissions; specifically, 11 military casualties and one civilian were diagnosed with mucormycosis. The median percentage Total Body Surface Area (TBSA) burned, 11 patients, or open wound, one patient, was 60 (IQR, 54.1-80.0), and the incidence of documented inhalation injury was 66.7% (8 of 12). Ten patients had surgical amputations. A median of eight days (IQR, 3.5-74.5) elapsed from diagnosis of mucormycosis until death in the 11 patients who expired. The overall mortality was 92%; however, autopsy attributed mucormycosis mortality was 54.5% (6 of 11) with all six patients having invasive mucormycosis.
Conclusion: Aggressive surgical intervention should be undertaken for invasive mucormycosis; additionally, implementation of standardized protocols for patients with large soft tissue injuries may mitigate mucormycosis superimposition. Published by Elsevier Ltd and ISBI
C1 [Mitchell, Thomas A.; Hardin, Mark O.; Murray, Clinton K.; Ritchie, John D.; Cancio, Leopoldo C.; Renz, Evan M.; White, Christopher E.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
RP White, CE (reprint author), Brooke Army Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM christopher.eric.white@us.army.mil
NR 17
TC 2
Z9 3
U1 1
U2 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0305-4179
EI 1879-1409
J9 BURNS
JI Burns
PD DEC
PY 2014
VL 40
IS 8
BP 1689
EP 1695
DI 10.1016/j.burns.2014.03.013
PG 7
WC Critical Care Medicine; Dermatology; Surgery
SC General & Internal Medicine; Dermatology; Surgery
GA AU1ER
UT WOS:000345364400039
PM 24881507
ER
PT J
AU Kamata, T
Natesan, M
Warfield, K
Aman, MJ
Ulrich, RG
AF Kamata, Teddy
Natesan, Mohan
Warfield, Kelly
Aman, M. Javad
Ulrich, Robert G.
TI Determination of Specific Antibody Responses to the Six Species of Ebola
and Marburg Viruses by Multiplexed Protein Microarrays
SO CLINICAL AND VACCINE IMMUNOLOGY
LA English
DT Article
ID LINKED-IMMUNOSORBENT-ASSAY; HEMORRHAGIC-FEVER VIRUSES;
NECROSIS-FACTOR-ALPHA; NUCLEOCAPSID PROTEINS; VIRION GLYCOPROTEINS;
IFN-ALPHA; NUCLEOPROTEIN; INFECTION; EPITOPES; TRANSCRIPTION
AB Infectious hemorrhagic fevers caused by the Marburg and Ebola filoviruses result in human mortality rates of up to 90%, and there are no effective vaccines or therapeutics available for clinical use. The highly infectious and lethal nature of these viruses highlights the need for reliable and sensitive diagnostic methods. We assembled a protein microarray displaying nucleoprotein (NP), virion protein 40 (VP40), and glycoprotein (GP) antigens from isolates representing the six species of filoviruses for use as a surveillance and diagnostic platform. Using the microarrays, we examined serum antibody responses of rhesus macaques vaccinated with trivalent (GP, NP, and VP40) virus-like particles (VLP) prior to infection with the Marburg virus (MARV) (i.e., Marburg marburgvirus) or the Zaire virus (ZEBOV) (i.e., Zaire ebolavirus). The microarray-based assay detected a significant increase in antigen-specific IgG resulting from immunization, while a greater level of antibody responses resulted from challenge of the vaccinated animals with ZEBOV or MARV. Further, while antibody cross-reactivities were observed among NPs and VP40s of Ebola viruses, antibody recognition of GPs was very specific. The performance of mucin-like domain fragments of GP (GP mucin) expressed in Escherichia coli was compared to that of GP ectodomains produced in eukaryotic cells. Based on results with ZEBOV and MARV proteins, antibody recognition of GP mucins that were deficient in posttranslational modifications was comparable to that of the eukaryotic cell-expressed GP ectodomains in assay performance. We conclude that the described protein microarray may translate into a sensitive assay for diagnosis and serological surveillance of infections caused by multiple species of filoviruses.
C1 [Kamata, Teddy; Natesan, Mohan; Ulrich, Robert G.] US Army, Med Res Inst Infect Dis, Frederick, MD 21702 USA.
[Warfield, Kelly; Aman, M. Javad] Integrated BioTherapeut Inc, Gaithersburg, MD USA.
RP Ulrich, RG (reprint author), US Army, Med Res Inst Infect Dis, Frederick, MD 21702 USA.
EM rulrich@bhsai.org
FU National Institute of Allergy and Infectious Diseases [R01AI096215];
Defense Threat Reduction Agency [CB3948]
FX This research was supported by the National Institute of Allergy and
Infectious Diseases (R01AI096215) and the Defense Threat Reduction
Agency (contract CB3948).
NR 51
TC 6
Z9 8
U1 1
U2 35
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 1556-6811
EI 1556-679X
J9 CLIN VACCINE IMMUNOL
JI Clin. Vaccine Immunol.
PD DEC
PY 2014
VL 21
IS 12
BP 1605
EP 1612
DI 10.1128/CVI.00484-14
PG 8
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA AU3RX
UT WOS:000345532300001
PM 25230936
ER
PT J
AU Dachir, S
Cohen, M
Sahar, R
Graham, J
Eisenkraft, A
Horwitz, V
Kadar, T
AF Dachir, Shlomit
Cohen, Maayan
Sahar, Rita
Graham, John
Eisenkraft, Arik
Horwitz, Vered
Kadar, Tamar
TI Beneficial effects of activated macrophages on sulfur mustard-induced
cutaneous burns, an in vivo experience
SO CUTANEOUS AND OCULAR TOXICOLOGY
LA English
DT Article
DE Hairless guinea pigs; macrophages; MMP; skin; TEWL
ID EAR VESICANT MODEL; WOUND REPAIR; NONINVASIVE METHODS; IRANIAN VETERANS;
HUMAN ULCERS; MOUSE MODEL; BLOOD UNIT; SKIN; INJURY; COMPLICATIONS
AB Objective: Macrophages are known to have key functions in almost every stage of wound healing and there is evidence for their beneficial effects in treating decubital ulcers and deep sternal wound infections in human. This study aimed to investigate the efficacy of a treatment with activated macrophages on ameliorating acute and long-term sulfur mustard (SM) induced skin injuries in the hairless guinea pig (HGP) model.
Methods: HGP were exposed to SM vapor and treated with either a single or multiple intradermal injections of human activated macrophages in suspension (hAMS) into the wound bed. Clinical and histological evaluations were conducted up to 4 weeks post-exposure.
Results: A single treatment with hAMS early after exposure (15 min and 6 h) resulted in a reduction in the number of damaged cells and vesications in the epidermis at 24 h. A substantial increase in cellular infiltration, mostly polymorphonuclears, was taking place in the hAMS-treated animals starting as early as 1 h after exposure. This flow of inflammatory cells continued, in the treated group, for at least 4 weeks, long after the injected macrophages were not detected. Repeated injections of hAMS (15 min, 48 h and 7 d post-exposure) decreased significantly the area of the wounds and improved the integrity of the barrier function as expressed by measuring trans-epidermal water loss up to 10 d.
Conclusions: Our results indicate that the role of macrophages in wound healing is complex; their efficacy may depend on the timing of administration. Further investigation is required to determine whether they are required during the early phase of wound development and/or during the late phase of scar formation and remodeling.
C1 [Dachir, Shlomit; Cohen, Maayan; Sahar, Rita; Horwitz, Vered; Kadar, Tamar] Israel Inst Biol Res, Dept Pharmacol, IL-74100 Ness Zion, Israel.
[Graham, John] US Army Med Res Inst Chem Def, Aberdeen Proving Ground, MD USA.
[Eisenkraft, Arik] Minist Def, NBC Protect Div, Tel Aviv, Israel.
[Eisenkraft, Arik] Med Corps Headquarters, IDF, Tel Aviv, Israel.
RP Dachir, S (reprint author), Israel Inst Biol Res, Dept Pharmacol, POB 19, IL-74100 Ness Zion, Israel.
EM shlomitd@iibr.gov.il
FU Defense Threat Reduction Agency - Joint Science and Technology Office,
Medical ST Division [W81XWH-08-2-128]
FX This work was supported by the Defense Threat Reduction Agency - Joint
Science and Technology Office, Medical S&T Division under award #:
W81XWH-08-2-128. The authors report no conflicts of interest.
NR 55
TC 1
Z9 2
U1 1
U2 6
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1556-9527
EI 1556-9535
J9 CUTAN OCUL TOXICOL
JI Cutan. Ocul. Toxicol.
PD DEC
PY 2014
VL 33
IS 4
BP 317
EP 326
DI 10.3109/15569527.2013.877023
PG 10
WC Ophthalmology; Toxicology
SC Ophthalmology; Toxicology
GA AU3FR
UT WOS:000345498400010
PM 24641113
ER
PT J
AU Park, S
Leonard, L
Handler, TE
Barstow, K
Cebe, KM
Chaudhuri, J
Hamelin, S
Hoskins, J
Tayob, N
Feng, ZD
Yamada, H
Xu, CB
Harrison, SA
AF Park, Stephen
Leonard, Lucas
Handler, Tristan E.
Barstow, Karol
Cebe, Katherine M.
Chaudhuri, Jayanata
Hamelin, Stefan
Hoskins, Jason
Tayob, Nabhah
Feng, Ziding
Yamada, Hiroyuki
Xu, Chuanbo
Harrison, Stephen A.
TI Development of a Non-Invasive Test for NAFLD That Distinguishes Isolated
Steatosis from NASH and NASH with Mild Fibrosis from NASH with Advanced
Fibrosis
SO HEPATOLOGY
LA English
DT Meeting Abstract
C1 [Park, Stephen; Leonard, Lucas; Handler, Tristan E.; Barstow, Karol; Cebe, Katherine M.; Chaudhuri, Jayanata; Hamelin, Stefan; Hoskins, Jason; Harrison, Stephen A.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
[Tayob, Nabhah; Feng, Ziding] Univ Texas Houston, MD Anderson Canc Ctr, Houston, TX 77030 USA.
[Yamada, Hiroyuki; Xu, Chuanbo] Wako Life Sci Inc, Mountain View, CA USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0270-9139
EI 1527-3350
J9 HEPATOLOGY
JI Hepatology
PD DEC
PY 2014
VL 60
IS 6
MA LB-17
BP 1278A
EP 1278A
PG 1
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA AU3MI
UT WOS:000345517000018
ER
PT J
AU Harrison, SA
Castiblanco, JE
Park, S
Handler, TE
Barstow, K
He, WJ
Harper, N
Ahuja, SK
AF Harrison, Stephen A.
Castiblanco, John E.
Park, Stephen
Handler, Tristan E.
Barstow, Karol
He, Weijing
Harper, Nathan
Ahuja, Sunil K.
TI Whole Genome RNA Sequencing (RNA-seq) Identifies CHI3L1 Gene Expression
as a Stronger Discriminator of Isolated Steatosis vs. NASH Compared with
Established Biomarker Scoring Systems
SO HEPATOLOGY
LA English
DT Meeting Abstract
C1 [Harrison, Stephen A.; Park, Stephen; Handler, Tristan E.; Barstow, Karol] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
[Castiblanco, John E.; He, Weijing; Harper, Nathan] South Texas Vet Hlth Care Syst, Vet Adm Ctr Personalized Med, San Antonio, TX USA.
[Ahuja, Sunil K.] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, San Antonio, TX 78229 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0270-9139
EI 1527-3350
J9 HEPATOLOGY
JI Hepatology
PD DEC
PY 2014
VL 60
IS 6
MA LB-41
BP 1290A
EP 1290A
PG 1
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA AU3MI
UT WOS:000345517000041
ER
PT J
AU Sherburn, JA
Hammons, MI
Roth, MJ
AF Sherburn, Jesse A.
Hammons, Michael I.
Roth, Michael J.
TI Modeling finite thickness slab perforation using a coupled
Eulerian-Lagrangian approach
SO INTERNATIONAL JOURNAL OF SOLIDS AND STRUCTURES
LA English
DT Article
DE Penetration; Coupled Eulerian-Lagrangian method; Concrete; Constitutive
law; Stochastic
ID PENETRATION; MECHANICS; TARGETS; PROJECTILES
AB A coupled Eulerian-Lagrangian (CEL) method can be used to model many types of dynamic events. Projectile penetration through solids is particularly well-suited to a CEL method. In this study the CEL method in the commercially-available code Abaqus was used to model a near rigid projectile perforating finite thickness concrete slabs. A near rigid projectile can be modeled as a Lagrangian material with distinct material interfaces, while the solid target can be modeled as an Eulerian material capable of large deformations. An improved concrete constitutive model is also described that was implemented into Abaqus as a user material model. A simplified stochastic model was also implemented to capture some of the heterogeneous nature of concrete. The CEL simulations are compared to experimental data to demonstrate the utility of this method for this type of perforation event. Published by Elsevier Ltd.
C1 [Sherburn, Jesse A.; Hammons, Michael I.; Roth, Michael J.] US Army, Engn Res & Dev Ctr, Vicksburg, MS USA.
RP Sherburn, JA (reprint author), 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM jesse.a.sherburn@usace.army.mil
NR 29
TC 2
Z9 2
U1 2
U2 12
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0020-7683
EI 1879-2146
J9 INT J SOLIDS STRUCT
JI Int. J. Solids Struct.
PD DEC
PY 2014
VL 51
IS 25-26
BP 4406
EP 4413
DI 10.1016/j.ijsolstr.2014.09.007
PG 8
WC Mechanics
SC Mechanics
GA AU2TM
UT WOS:000345470400018
ER
PT J
AU Hempen, GL
Keevin, TM
Rodgers, MT
Schneider, BM
AF Hempen, G. L.
Keevin, T. M.
Rodgers, M. T.
Schneider, B. M.
TI Mechanical rock grinding in the Mississippi River: anthropogenic noise
production and implications for the federally endangered pallid
sturgeon, Scaphirhynchus albus (Forbes & Richardson, 1905)
SO JOURNAL OF APPLIED ICHTHYOLOGY
LA English
DT Article; Proceedings Paper
CT 7th International Symposium on Sturgeons - Sturgeons, Science and
Society at the Cross-Roads - Meeting the Challenges of the 21st Century
CY JUL 21-25, 2013
CL Nanaimo, CANADA
SP Vancouver Isl Univ, WSCS
ID INNER-EAR; SOUND; FISH; ABUNDANCE; COD
AB The use of mechanical rock grinding to remove rock pinnacles and outcroppings, considered to be navigation hazards in the Mississippi River, was evaluated as a less damaging alternative when compared to the more conventional use of drilling and blasting. The project area contains the federally endangered pallid sturgeon (Scaphirhynchus albus) and there was concern that intense sound pressure levels (SPLs) could impact the species. SPLs were measured during production rock grinding (January 2012, just north of Thebes, Illinois) and compared to those values with SPLs known to cause fish mortality, hearing damage, temporary hearing threshold shifts (TTS), and stress. The source SPLs' maxima for each time block analyzed ranged from 160-172dB (re 1Pa @ 1m) at frequencies ranging from 100-1250Hz (1/3-octave band). The highest source SPL maximum recorded for the sound recording session was 172dB (re 1Pa @ 1m) at 1250Hz. These SPL levels at 1m from the grinder were well below levels responsible for mortality or noise induced hearing damage. The impact zone for stress (increases in cortisol) was calculated to be within a 9m radius of the grinder, while the impact zone for TTS was calculated to be within 31m of the grinder. Considering the small impact zones and continuous noise production during grinding, there is a strong possibility that sturgeon would either avoid or move out of the impact zone.
C1 [Hempen, G. L.; Keevin, T. M.; Rodgers, M. T.; Schneider, B. M.] US Army Corps Engineers, St Louis, MO 63103 USA.
RP Hempen, GL (reprint author), US Army Corps Engineers, 1222 Spruce St, St Louis, MO 63103 USA.
EM hempen69@sbcglobal.net
NR 26
TC 0
Z9 0
U1 0
U2 14
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0175-8659
EI 1439-0426
J9 J APPL ICHTHYOL
JI J. Appl. Ichthyol.
PD DEC
PY 2014
VL 30
IS 6
SI SI
BP 1492
EP 1496
DI 10.1111/jai.12582
PG 5
WC Fisheries; Marine & Freshwater Biology
SC Fisheries; Marine & Freshwater Biology
GA AU4NO
UT WOS:000345588500052
ER
PT J
AU Cole, SD
Madren-Whalley, JS
Li, AP
Dorsey, R
Salem, H
AF Cole, Stephanie D.
Madren-Whalley, Janna S.
Li, Albert P.
Dorsey, Russell
Salem, Harry
TI High Content Analysis of an In Vitro Model for Metabolic Toxicity:
Results with the Model Toxicants 4-Aminophenol and Cyclophosphamide
SO JOURNAL OF BIOMOLECULAR SCREENING
LA English
DT Article
DE metabolism; in vitro toxicology; high content analysis; co-culture;
human hepatocytes; 3T3-L1 cells
ID CYTOTOXIC METABOLITES; HEPATOCYTES
AB In vitro models that accurately and rapidly assess hepatotoxicity and the effects of hepatic metabolism on nonliver cell types are needed by the U.S. Department of Defense and the pharmaceutical industry to screen compound libraries. Here, we report the first use of high content analysis on the Integrated Discrete Multiple Organ Co-Culture (IdMOC) system, a high-throughput method for such studies. We cultured 3T3-L1 cells in the presence and absence of primary human hepatocytes, and exposed the cultures to 4-aminophenol and cyclophosphamide, model toxicants that are respectively detoxified and activated by the liver. Following staining with calcein-AM, ethidium homodimer-1, and Hoechst 33342, high content analysis of the cultures revealed four cytotoxic endpoints: fluorescence intensities of calcein-AM and ethidium homodimer-1, nuclear area, and cell density. Using these endpoints, we observed that the cytotoxicity of 4-aminophenol in 3T3-L1 cells in co-culture was less than that observed for 3T3-L1 monocultures, consistent with the known detoxification of 4-aminophenol by hepatocytes. Conversely, cyclophosphamide cytotoxicity for 3T3-L1 cells was enhanced by co-culturing with hepatocytes, consistent with the known metabolic activation of this toxicant. The use of IdMOC plates combined with high content analysis is therefore a multi-endpoint, high-throughput capability for measuring the effects of metabolism on toxicity.
C1 [Cole, Stephanie D.] CNR, Res Associate Program, Washington, DC 20418 USA.
[Madren-Whalley, Janna S.; Dorsey, Russell; Salem, Harry] US Army Res Dev & Engn Command, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA.
[Li, Albert P.] Vitro ADMET Labs Inc, Columbia, MD USA.
[Salem, Harry] Chem Secur Assessment Ctr, Dept Homeland Secur, Aberdeen Proving Ground, MD USA.
RP Cole, SD (reprint author), 5183 Blackhawk Rd, Gunpowder, MD 21010 USA.
EM stephanie.d.cole9.ctr@mail.mil
OI Li, Albert/0000-0001-5772-6265
FU National Research Council Research (NRC); Defense Threat Reduction
Agency's Chemical and Biological Defense Program
FX The authors disclosed receipt of the following financial support for the
research, authorship, and/or publication of this article: This research
was funded by the National Research Council Research (NRC) and the
Defense Threat Reduction Agency's Chemical and Biological Defense
Program while Stephanie Cole held an NRC Research Associateship Award at
the Edgewood Chemical Biological Center.
NR 14
TC 4
Z9 4
U1 1
U2 14
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1087-0571
EI 1552-454X
J9 J BIOMOL SCREEN
JI J. Biomol. Screen
PD DEC
PY 2014
VL 19
IS 10
BP 1402
EP 1408
DI 10.1177/1087057114550399
PG 7
WC Biochemical Research Methods; Biotechnology & Applied Microbiology;
Chemistry, Analytical
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
Chemistry
GA AU2PX
UT WOS:000345461400008
PM 25239051
ER
PT J
AU Boves, TJ
Sperry, JH
Comolli, K
Weatherhead, PJ
AF Boves, Than J.
Sperry, Jinelle H.
Comolli, Kristin
Weatherhead, Patrick J.
TI Brood parasitism of Black-capped Vireos: frontline and post-laying
behavioral responses and effects on productivity
SO JOURNAL OF FIELD ORNITHOLOGY
LA English
DT Article
DE adaptive behavior; Brown-headed Cowbird; coevolution; Molothrus ater;
nest abandonment; nest desertion; Vireo atricapilla
ID BROWN-HEADED COWBIRDS; YELLOW WARBLER EGGS; NEST DESERTION; REPRODUCTIVE
SUCCESS; CLUTCH ABANDONMENT; PREDATION RISK; MIGRATORY BIRD; BELLS
VIREO; HOST; REMOVAL
AB The cost of brood parasitism favors the evolution of host behaviors that reduce the risk or expense of being parasitized. Endangered Black-capped Vireos (Vireo atricapilla) have likely coexisted with brood-parasitic Brown-headed Cowbirds (Molothrus ater) for more than 10,000 yr, so it is likely that they have evolved anti-parasitic behaviors. We monitored naturally parasitized and non-parasitized vireo nests to evaluate factors that might explain parasitism risk and nest desertion behavior and also assessed whether behaviors that occurred after being parasitized improved reproductive output. Vireos reduced the risk of parasitism by initiating breeding early and nesting farther from open grasslands and edges of woody thickets. Post-laying, nest desertion was common (70% of parasitized nests) and increased with both the presence of at least one cowbird egg in nests and clutch reduction by cowbirds. After accounting for these cues, desertion was also more likely at nests located closer to cowbird foraging habitat and below potential cowbird vantage points. Despite its regularity, desertion did not appear to provide reproductive benefits to vireos. Instead, accepting cowbird eggs was a more effective strategy because 42% of cowbird eggs did not hatch. Furthermore, cowbird eggs were somehow ejected from at least three vireo nests. Our results suggest that Black-capped Vireos can behave in a variety of ways that reduce the impact of brood parasitism, with frontline behaviors appearing to provide the greatest benefit. Our results also suggest that habitat management should focus on providing Black-capped Vireos with adequate breeding habitat that provides access to safe nesting sites, and with high-quality wintering habitat that allows vireos to migrate and initiate nesting early.
RESUMEN Parasitismo reproductivo en Vireo atricapilla: respuestas de conducta pre y post-puesta y su efecto en la productividad El costo del parasitismo reproductivo favorece la evolucion de la conducta del huesped para que de alguna manera reduzca el riesgo o el costo de ser parasitado. El Vireo (Vireo atricapilla) ha coexistido, por mas de 10,000 anos, con el Tordo pardo (Molothrus ater) que es un parasito reproductivo y es posible que haya desarrollado alguna conducta anti parasitica. Monitoreamos nidos no parasitados y otros parasitados para evaluar los factoras que puedan explicar el riesgo parasitico y la conducta de abandonar el nido, y tambien si la conducta llevada a cabo, luego de ser parasitado un nido, mejora el rendimiento reproductivo. Los vireos reducen el riesgo de ser parasitados comenzando a reproducirse temprano y anidando lejos de herbazales abiertos y bordes de matorrales. El abandono de nidos, luego de la puesta, fue algo comun (70% de los nidos parasitados) e incremento, con la presencia de al menos un huevo de tordo o la reduccion de la camada de parte del parasito (remocion de huevos). Luego de tomar estas pistas en consideracion, la probabilidad de desercion fue mayor en nidos mas cercanos a las areas de forrajeo de los tordos y bajo el potencial de ventaja de los tordos. Pese a su regularidad, la desercion de nidos no parece proveer de beneficio reproductivo a los vireos. El aceptar los huevos de tordo resulto ser una estrategia mas efectiva porque el 42% de estos no eclosionaron. Mas aun, los huevos de tordo fueron sacados del nido en al menos tres nidos de vireos. Nuestros resultados sugieren que los vireos pueden conducirse de varias formas que a su vez puede reducir el impacto de parasitismo reproductivo, y exhibir conductas noveles que parecen proveer gran beneficio. Nuestros datos tambien sugieren que el manejo de habitat debe enfocar en proveer a los vireos de habitat adecuado para anidar, de lugares mas seguros para reproducirse y habitat invernal de gran calidad, que le permita a estos migrar e iniciar temprano el anidamiento.
C1 [Boves, Than J.] Arkansas State Univ, Dept Biol Sci, Jonesboro, AR 72401 USA.
[Boves, Than J.; Comolli, Kristin] Univ Illinois, Dept Nat Resources & Environm Sci, Urbana, IL 61801 USA.
[Sperry, Jinelle H.] Engineer Res & Dev Ctr, Champaign, IL 61826 USA.
[Weatherhead, Patrick J.] Univ Illinois, Program Ecol Evolut & Conservat Biol, Urbana, IL 61822 USA.
RP Boves, TJ (reprint author), Arkansas State Univ, Dept Biol Sci, Jonesboro, AR 72401 USA.
EM tboves@astate.edu
FU U.S. Army; Army Corps of Engineers, Engineer Research and Development
Center; United States Geological Survey [12052]
FX Funding for this project was provided by the U.S. Army through an
agreement between the Natural Resources Management Branch at Fort Hood,
U.S. Army ERDC, and University of Illinois Urbana-Champaign. Additional
support was provided by Army Corps of Engineers, Engineer Research and
Development Center. We thank T. Buchanan and T. Hayden for help in
arranging funding. We thank J. A. Kutylowski and several other
biologists for field assistance. We thank G. Ritchison and two anonymous
reviewers for comments that greatly improved the manuscript. Banding was
conducted under the auspices of United States Geological Survey, permit
#12052.
NR 70
TC 2
Z9 2
U1 4
U2 39
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0273-8570
EI 1557-9263
J9 J FIELD ORNITHOL
JI J. Field Ornithol.
PD DEC
PY 2014
VL 85
IS 4
BP 364
EP 378
DI 10.1111/jofo.12076
PG 15
WC Ornithology
SC Zoology
GA AU4IE
UT WOS:000345573200003
ER
PT J
AU Cardile, AP
Sanchez, CJ
Hardy, SK
Romano, DR
Hurtgen, BJ
Wenke, JC
Murray, CK
Akers, KS
AF Cardile, Anthony P.
Sanchez, Carlos J., Jr.
Hardy, Sharanda K.
Romano, Desiree R.
Hurtgen, Brady J.
Wenke, Joseph C.
Murray, Clinton K.
Akers, Kevin S.
TI Dakin solution alters macrophage viability and function
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE Sodium hypochlorite; Dakin solution; Macrophages; Phagocytosis
ID TOPICAL ANTIMICROBIAL AGENTS; SODIUM-HYPOCHLORITE; DERMAL FIBROBLASTS;
IN-VITRO; INFECTIONS; TOXICITY; CELLS; POLYMORPHONUCLEAR; ASPERGILLUS;
MONONUCLEAR
AB Background: Macrophages are important in wound defense and healing. Dakin's solution (DS), buffered sodium hypochlorite, has been used since World War I as a topical antimicrobial for wound care. DS has been shown to be toxic to host cells, but effects on immune cells are not well documented.
Materials and methods: DS at 0.5%, 0.125%, and ten-fold serial dilutions from 0.25%-0.00025% were evaluated for cellular toxicity on murine macrophages (J774A.1). The effect of DS on macrophage adhesion, phagocytosis, and generation of reactive oxygen species was examined. Macrophage polarization following DS exposure was determined by gene expression using quantitative real-time polymerase chain reaction.
Results: Concentrations of DS >0.0025% reduced macrophage viability to <5% in exposure times as short as 30 s. Similarly, phagocytosis of Staphylococcus aureus, Pseudomonas aeruginosa, and Aspergillus flavus were significantly reduced at all tested concentrations by macrophages pretreated with DS. H2O2 production was reduced by 8%-38% following treatment with 0.00025%-0.125% DS. Macrophage adherence was significantly increased with >0.0025% DS after 15 min of exposure compared with controls. Quantitative real-time polymerase chain reaction demonstrated that DS exposure resulted in classical macrophage activation, with increased expression of inducible nitric oxide synthase 2, interferon-gamma, and interleukin (IL)-1 beta.
Conclusions: DS at clinically used concentrations (0.025%-0.25%) was detrimental to macrophage survival and function. For optimal clinical use, understanding the impact of DS on macrophages is important as depletion may result in impaired pathogen clearance and delayed healing. These findings indicate that 0.00025% DS is a safe starting dose; however, optimal use of DS requires further validation with in vivo models. Published by Elsevier Inc.
C1 [Cardile, Anthony P.; Murray, Clinton K.; Akers, Kevin S.] Brooke Army Med Ctr, Infect Dis Serv MCHE MDI, Houston, TX 78234 USA.
[Sanchez, Carlos J., Jr.; Hardy, Sharanda K.; Romano, Desiree R.; Hurtgen, Brady J.; Wenke, Joseph C.; Akers, Kevin S.] US Army Inst Surg Res, Dept Extrem Trauma & Regenerat Med, Houston, TX 78234 USA.
RP Cardile, AP (reprint author), Brooke Army Med Ctr, Infect Dis Serv MCHE MDI, 3551 Roger Brooke Dr,JBSA Ft Sam, Houston, TX 78234 USA.
EM anthony.p.cardile.mil@mail.mil
FU National Research Council; Combat Casualty Research Program, Medical
Research and Material Command
FX C.J.S. and B.J.H. are supported through a post-doctoral research
fellowship through National Research Council. Portions of this work were
presented at the 2013 IDSA Annual Meeting, San Francisco, CA in October
2013. This work was supported by intramural funding from the Combat
Casualty Research Program, Medical Research and Material Command to
J.C.W.
NR 39
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U1 0
U2 6
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD DEC
PY 2014
VL 192
IS 2
BP 692
EP 699
DI 10.1016/j.jss.2014.07.019
PG 8
WC Surgery
SC Surgery
GA AU2BA
UT WOS:000345419900064
PM 25130774
ER
PT J
AU Chandler, MQ
Allison, PG
Rodriguez, RI
Moser, RD
Kennedy, AJ
AF Chandler, Mei Qiang
Allison, Paul G.
Rodriguez, Rogie I.
Moser, Robert D.
Kennedy, Alan J.
TI Finite element modeling of multilayered structures of fish scales
SO JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
LA English
DT Article
DE Atractosteus spatula; Polypterus senegalus; Multilayered structure;
Finite element; Fracture
ID MECHANICAL-PROPERTIES; LAMINATE STRUCTURE; ARAPAIMA-GIGAS; RESISTANCE
AB The interlinked fish scales of Atractosteus spatula (alligator gar) and Polypterus senegalus (gray and albino bichir) are effective multilayered armor systems for protecting fish from threats such as aggressive conspecific interactions or predation. Both types of fish scales have multi-layered structures with a harder and stiffer outer layer, and softer and more compliant inner layers. However, there are differences in relative layer thickness, property mismatch between layers, the property gradations and nanostructures in each layer. The fracture paths and patterns of both scales under microindentation loads were different. In this work, finite element models of fish scales of A. spatula and P. senegalus were built to investigate the mechanics of their multilayered structures under penetration loads. The models simulate a rigid microindenter penetrating the fish scales quasi-statically to understand the observed experimental results. Study results indicate that the different fracture patterns and crack paths observed in the experiments were related to the different stress fields caused by the differences in layer thickness, and spatial distribution of the elastic and plastic properties in the layers, and the differences in interface properties. The parametric studies and experimental results suggest that smaller fish such as P. senegalus may have adopted a thinner outer layer for light-weighting and improved mobility, and meanwhile adopted higher strength and higher modulus at the outer layer, and stronger interface properties to prevent ring cracking and interface cracking, and larger fish such as A. spatula and Arapaima gigas have lower strength and lower modulus at the outer layers and weaker interface properties, but have adopted thicker outer layers to provide adequate protection against ring cracking and interface cracking, possibly because weight is less of a concern relative to the smaller fish such as P. senegalus. Published by Elsevier Ltd.
C1 [Chandler, Mei Qiang; Moser, Robert D.; Kennedy, Alan J.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Allison, Paul G.; Rodriguez, Rogie I.] Univ Alabama, Dept Mech Engn, Tuscaloosa, AL 35487 USA.
RP Chandler, MQ (reprint author), US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
EM Mei.Q.Chandler@usace.army.mil
OI Allison, Paul/0000-0002-9041-237X
FU US Army Engineer Research and Development Center (ERDC) Military
Engineering 6.1 Basic Research Program
FX The authors acknowledge the financial support for this work provided by
the US Army Engineer Research and Development Center (ERDC) Military
Engineering 6.1 Basic Research Program. Permission to publish was
granted by the Director, ERDC Geotechnical and Structures Laboratory.
NR 18
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Z9 4
U1 2
U2 16
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1751-6161
EI 1878-0180
J9 J MECH BEHAV BIOMED
JI J. Mech. Behav. Biomed. Mater.
PD DEC
PY 2014
VL 40
BP 375
EP 389
DI 10.1016/j.jmbbm.2014.09.013
PG 15
WC Engineering, Biomedical; Materials Science, Biomaterials
SC Engineering; Materials Science
GA AU2SU
UT WOS:000345468700037
PM 25300062
ER
PT J
AU Scott, DJ
Watson, JDB
Heafner, TA
Clemens, MS
Propper, BW
Arthurs, ZM
AF Scott, Daniel J.
Watson, J. Devin B.
Heafner, Thomas A.
Clemens, Michael S.
Propper, Brandon W.
Arthurs, Zachary M.
TI Validation of the Short Musculoskeletal Function Assessment in patients
with battlefield-related extremity vascular injuries
SO JOURNAL OF VASCULAR SURGERY
LA English
DT Article; Proceedings Paper
CT Vascular Annual Meeting of the Society-for-Vascular-Surgery / Spring
Meeting of the Vascular-and-Endovascular-Surgery-Society
CY JUN 04-07, 2014
CL Boston, MA
SP Soc Vasc Surg, Vasc & Endovascular Surg Soc
ID FUNCTION ASSESSMENT QUESTIONNAIRE; CROSS-CULTURAL ADAPTATION; HEALTH
SURVEY SF-36; PENETRATING FEMOROPOPLITEAL INJURY; FUNCTION ASSESSMENT
SMFA; DAMAGE CONTROL ADJUNCT; MODERN WARFARE; VALIDITY; OUTCOMES;
RESPONSIVENESS
AB Objective: Vascular extremity injuries can be a significant burden on a patient's long-term quality of life. Currently, no limb-specific surveys have been used to quantify the relation between injury pattern and the resultant physical or psychological impact. The objective of this study was to validate the use of the Short Musculoskeletal Function Assessment (SMFA) in the setting of extremity vascular injury.
Methods: The Joint Theater Trauma Registry was queried and filtered for U.S. troops with an extremity vascular injury isolated to a single limb. Injury and management data were obtained, and the SMFA was administered after patient contact and consent. Validity was analyzed by characterization of SMFA score distribution, correlation with 36-Item Short Form Health Survey (SF-36) scores, and assessment of its discriminative capability to external measures of injury severity (ie, Injury Severity Score [ISS], Mangled Extremity Severity Score [MESS], and Medicare Part A disability qualification).
Results: At mean follow-up of 5 years, 164 patients (median age, 25 years; interquartile range, 22-31 years) completed both surveys. The overall SMFA Dysfunction Index was 24.8 +/- 15.2 (range, 0-78; skewness, 0.60; floor/ceiling effect, 0%-1.2%; and nonresponse, 0%), and the overall Bother Index was 29.4 +/- 20.2 (range, 0-96; skewness, 0.58; floor/ceiling effect, 0%-4.3%; and nonresponse, 0.6%). SF-36 physical component summary scores correlated inversely with the Dysfunction Index (r = -0.64; P < .01), whereas mental component summary scores correlated inversely with the Bother Index (r = -0.59; P < .01). No difference was found in reported scores between those considered severely injured (ISS > 15) and those not severely injured (ISS <= 15). However, those with mangled extremities (MESS >= 7) reported higher Dysfunction and Bother indices than those with lower scores (P < .05). In addition, patients considered disabled (per Medicare Part A qualifications) reported higher Dysfunction and Bother indices compared with those not considered disabled (P < .05).
Conclusions: Use of the SMFA is validated in those with extremity vascular injuries, and it should be considered an adjunctive tool in evaluating long-term patient outcomes.
C1 [Scott, Daniel J.; Watson, J. Devin B.; Heafner, Thomas A.; Propper, Brandon W.] Lackland AFB, Clin Res Div 59, San Antonio, TX USA.
[Scott, Daniel J.; Watson, J. Devin B.; Heafner, Thomas A.; Clemens, Michael S.; Propper, Brandon W.; Arthurs, Zachary M.] US Army, Inst Surg Res, Chambers Pass, Ft Sam Houston, TX 78234 USA.
RP Scott, DJ (reprint author), San Antonio Mil Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM danscott34@gmail.com
NR 34
TC 1
Z9 1
U1 0
U2 4
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0741-5214
J9 J VASC SURG
JI J. Vasc. Surg.
PD DEC
PY 2014
VL 60
IS 6
BP 1620
EP 1626
DI 10.1016/j.jvs.2014.08.060
PG 7
WC Surgery; Peripheral Vascular Disease
SC Surgery; Cardiovascular System & Cardiology
GA AU3MX
UT WOS:000345518600030
PM 25242269
ER
PT J
AU Milner, JL
Abu-Farha, F
Kurfess, T
Hammond, VH
AF Milner, Justin L.
Abu-Farha, Fadi
Kurfess, Thomas
Hammond, Vincent H.
TI Effects of induced shear deformation on microstructure and texture
evolution in CP-Ti rolled sheets
SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES
MICROSTRUCTURE AND PROCESSING
LA English
DT Article
DE Titanium; Shear rolling; Texture; Stretch formability; Digital image
correlation
ID SEVERE PLASTIC-DEFORMATION; AZ31 MAGNESIUM ALLOY; BONDING ARB PROCESS;
MECHANICAL-PROPERTIES; PURE TITANIUM; GRAIN-REFINEMENT; ALUMINUM;
RECRYSTALLIZATION; IMPROVEMENT; DUCTILITY
AB Commercial pure titanium sheets were deformed by shear rolling at 400 degrees C with subsequent annealing to investigate microstructure and texture evolution along with its effects on the mechanical properties. A four sheet multilayer rolling scheme was used to isolate shear strains within the outer sheets, termed isolated shear rolling (ISR), thus allowing for direct comparison between shear strained material (outer sheets) and plane-strained material under similar conditions. Microstructure and texture evolution were investigated by electron backscatter diffraction analysis, while mechanical properties were evaluated through tensile testing aided by digital image correlation (DIC). Texture was seen to evolve from a +/- 30 degrees transverse direction (TD) split basal texture to primarily basal texture ((0001)//Normal Direction) for the shear-strained sheets, in comparison with a slight rotation to a +/- 20 degrees TD-split for the plane-strained sheets. After short-term annealing at 600 degrees C for 15 min, texture remained similar to that of the as-processed material yet at lower intensity levels. Compared to the base material, shear-rolled material showed much higher Lankford Coefficient values, with a significant boost attributed to shear deformation. The greater stretch formability is achieved in the shear-rolled material by rotation of the basal poles to become parallel to the sheet thickness. The results obtained here with ISR in regards to the effects of inducing higher shear strains on the rolled material are comparable to those reported in the literature by differential speed rolling (DSR). (C) 2014 Elsevier B.V. All rights reserved.
C1 [Milner, Justin L.; Abu-Farha, Fadi] Clemson Univ, Dept Automot Engn, Greenville, SC 29607 USA.
[Kurfess, Thomas] Georgia Inst Technol, Sch Mech Engn, Atlanta, GA 30332 USA.
[Hammond, Vincent H.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Abu-Farha, F (reprint author), Clemson Univ, Dept Automot Engn, Greenville, SC 29607 USA.
EM FADI@clemson.edu
FU U.S. Army Research Laboratory [W911NF-10-1-0413]
FX The authors are grateful to RTI International Metals for providing
access to the rolling mill using which all the ISR runs reported in this
work were performed. All the electron microscopy work was performed at
the Advanced Material Research Lab (AMRL) of Clemson University; the
efforts of their team are greatly appreciated. This work was supported
in part by the U.S. Army Research Laboratory under Grant number
W911NF-10-1-0413.
NR 30
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U1 5
U2 26
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0921-5093
EI 1873-4936
J9 MAT SCI ENG A-STRUCT
JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process.
PD DEC 1
PY 2014
VL 619
BP 12
EP 25
DI 10.1016/j.msea.2014.09.004
PG 14
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary;
Metallurgy & Metallurgical Engineering
SC Science & Technology - Other Topics; Materials Science; Metallurgy &
Metallurgical Engineering
GA AU2TD
UT WOS:000345469500002
ER
PT J
AU Busey, B
Berry-Caban, CS
Hoedebecke, K
Barts, RN
AF Busey, Blake
Berry-Caban, Cristobal S.
Hoedebecke, Kyle
Barts, Rachel N.
TI A Rare Case of Moyamoya Disease in a 20-year-old Puerto Rican Female US
Soldier
SO PUERTO RICO HEALTH SCIENCES JOURNAL
LA English
DT Article
DE Moyamoya; Cerebrovascular occlusive disease; Ischemia
AB Moyamoya disease is a progressive, occlusive pathology involving the cerebral vasculature with particular involvement of the circle of Willis and its tributaries. The cause of moyamoya disease is unknown, but is believed to be hereditary. Females 20 to 39 years old with moyamoya represent 0.5% of all acute cerebral ischemia and infarcts with risk factors including smoking, estrogen- containing birth control use, coagulopathy, neoplasm, and congenital malformation. This case reports on a 20-year-old Puerto Rican female U.S. soldier with a 1-year history of migraine headaches with worsening right retro-orbital pain, blurred vision, and photophobia. The patient had minimal unilateral neurological deficits despite evidence of significant cerebral infarction on non-contrast computed tomography. Other neuroimaging findings were consistent with moyamoya disease with confirmation via cerebral angiography. This case details the process of diagnosis and treatment as well as discussing its incidence, identification, and treatment options.
C1 [Busey, Blake] Soldier Family Med Ctr, Ft Bliss, TX USA.
[Berry-Caban, Cristobal S.; Barts, Rachel N.] Womack Army Med Ctr, Dept Clin Invest, Ft Bragg, NC 28310 USA.
[Hoedebecke, Kyle] 82nd Combat Aviat Brigade, Ft Bragg, NC USA.
RP Berry-Caban, CS (reprint author), Womack Army Med Ctr, Dept Clin Invest, 2817 Reilly Rd, Ft Bragg, NC 28310 USA.
EM cristobal.s.berry-caban.civ@mail.mil
NR 12
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U1 0
U2 0
PU UNIV PUERTO RICO MEDICAL SCIENCES CAMPUS
PI SAN JUAN
PA OFFICE DEAN ACADEMIC AFFAIRS BOX 365067, SAN JUAN, PR 00936-5067 USA
SN 0738-0658
J9 P R HEALTH SCI J
JI P. R. Health Sci. J.
PD DEC
PY 2014
VL 33
IS 4
BP 197
EP 199
PG 3
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA AU3QS
UT WOS:000345529300008
PM 25563038
ER
PT J
AU Carlisle, P
Silliman, D
Talley, A
Tucker, D
Hale, R
Guelcher, S
Baer, PB
AF Carlisle, P.
Silliman, D.
Talley, A.
Tucker, D.
Hale, R.
Guelcher, S.
Baer, P. Brown
TI Localized Low Dose rhBMP-2 Is Effective at Promoting Bone Regeneration
in a Pre-Clinical Mandibular Segmental Defect Model
SO TISSUE ENGINEERING PART A
LA English
DT Meeting Abstract
CT TERMIS-AM Conference
CY DEC 13-16, 2014
CL Washington, DC
SP TERMIS AM
C1 [Carlisle, P.; Silliman, D.; Tucker, D.; Hale, R.; Baer, P. Brown] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Talley, A.; Guelcher, S.] Vanderbilt Univ, Sch Engn, Nashville, TN 37235 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1937-3341
EI 1937-335X
J9 TISSUE ENG PT A
JI Tissue Eng. Part A
PD DEC 1
PY 2014
VL 20
SU 1
MA O-246
BP S19
EP S19
PG 1
WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell
Biology
SC Cell Biology; Biotechnology & Applied Microbiology
GA AU6AK
UT WOS:000345684300066
ER
PT J
AU Guo, R
Ward, C
Nanney, L
Guelcher, S
AF Guo, R.
Ward, C.
Nanney, L.
Guelcher, S.
TI An Injectable and Settable Cell Delivery System Derived from In Situ
Chemical Polymerization Promotes Healing in a Porcine Full-Thickness
Excisional Wound Model
SO TISSUE ENGINEERING PART A
LA English
DT Meeting Abstract
CT TERMIS-AM Conference
CY DEC 13-16, 2014
CL Washington, DC
SP TERMIS AM
C1 [Guo, R.; Nanney, L.; Guelcher, S.] Vanderbilt Univ, Nashville, TN 37235 USA.
[Ward, C.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1937-3341
EI 1937-335X
J9 TISSUE ENG PT A
JI Tissue Eng. Part A
PD DEC 1
PY 2014
VL 20
SU 1
MA P-195
BP S70
EP S71
PG 2
WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell
Biology
SC Cell Biology; Biotechnology & Applied Microbiology
GA AU6AK
UT WOS:000345684300273
ER
PT J
AU Roy, D
Kowalczewski, C
Hall, R
Burnett, L
Tomblyn, S
Saul, J
Christy, R
AF Roy, D.
Kowalczewski, C.
Hall, R.
Burnett, L.
Tomblyn, S.
Saul, J.
Christy, R.
TI Antibiotic-Loaded Keratin Hydrogels Prevent Infection in a
Full-Thickness Porcine Excision Wound
SO TISSUE ENGINEERING PART A
LA English
DT Meeting Abstract
CT TERMIS-AM Conference
CY DEC 13-16, 2014
CL Washington, DC
SP TERMIS AM
C1 [Roy, D.; Christy, R.] US Army Inst Surg Res, Ft Sam Houston, TX USA.
[Kowalczewski, C.; Hall, R.; Saul, J.] Miami Univ, Oxford, OH 45056 USA.
[Burnett, L.; Tomblyn, S.] KeraNetics, Winston Salem, NC USA.
NR 0
TC 0
Z9 0
U1 2
U2 4
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1937-3341
EI 1937-335X
J9 TISSUE ENG PT A
JI Tissue Eng. Part A
PD DEC 1
PY 2014
VL 20
SU 1
MA P-148
BP S64
EP S64
PG 1
WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell
Biology
SC Cell Biology; Biotechnology & Applied Microbiology
GA AU6AK
UT WOS:000345684300245
ER
PT J
AU Silliman, D
Carlisle, P
Owens, D
Tucker, D
Hale, R
BrownBaer, P
AF Silliman, D.
Carlisle, P.
Owens, D.
Tucker, D.
Hale, R.
BrownBaer, P.
TI Segmental Mandibular Defects in Sinclair Miniature Pigs Mimic Human
Mandibular Reconstruction Cases
SO TISSUE ENGINEERING PART A
LA English
DT Meeting Abstract
CT TERMIS-AM Conference
CY DEC 13-16, 2014
CL Washington, DC
SP TERMIS AM
C1 [Silliman, D.; Carlisle, P.; Owens, D.; Tucker, D.; Hale, R.; BrownBaer, P.] US Army Inst Surg Res, JBSA Ft Sam Houston, Ft Sam Houston, TX 78234 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1937-3341
EI 1937-335X
J9 TISSUE ENG PT A
JI Tissue Eng. Part A
PD DEC 1
PY 2014
VL 20
SU 1
MA P-244
BP S77
EP S78
PG 2
WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell
Biology
SC Cell Biology; Biotechnology & Applied Microbiology
GA AU6AK
UT WOS:000345684300302
ER
PT J
AU Wang, H
Kaini, RR
Burke, TA
Golden, DJ
Johnson, AJ
AF Wang, H.
Kaini, R. R.
Burke, T. A.
Golden, D. J.
Johnson, A. J.
TI Matrix Proteins and Retina Development in a 3D In Vitro System
SO TISSUE ENGINEERING PART A
LA English
DT Meeting Abstract
CT TERMIS-AM Conference
CY DEC 13-16, 2014
CL Washington, DC
SP TERMIS AM
C1 [Wang, H.; Kaini, R. R.; Johnson, A. J.] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX USA.
[Burke, T. A.; Golden, D. J.] Cherokee Nation Businesses, Jbsa Ft Sam Houston, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1937-3341
EI 1937-335X
J9 TISSUE ENG PT A
JI Tissue Eng. Part A
PD DEC 1
PY 2014
VL 20
SU 1
MA O-271
BP S21
EP S22
PG 2
WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell
Biology
SC Cell Biology; Biotechnology & Applied Microbiology
GA AU6AK
UT WOS:000345684300077
ER
PT J
AU Wehmeyer, JL
Lund, BJ
Edsall, PR
Zamora, DO
AF Wehmeyer, J. L.
Lund, B. J.
Edsall, P. R.
Zamora, D. O.
TI Development of a Novel Method for the De-Epithelialization of Amniotic
Membrane
SO TISSUE ENGINEERING PART A
LA English
DT Meeting Abstract
CT TERMIS-AM Conference
CY DEC 13-16, 2014
CL Washington, DC
SP TERMIS AM
C1 [Wehmeyer, J. L.; Lund, B. J.; Edsall, P. R.; Zamora, D. O.] US Army Inst Surg Res, Ft Sam Houston, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1937-3341
EI 1937-335X
J9 TISSUE ENG PT A
JI Tissue Eng. Part A
PD DEC 1
PY 2014
VL 20
SU 1
MA P-562
BP S118
EP S118
PG 1
WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell
Biology
SC Cell Biology; Biotechnology & Applied Microbiology
GA AU6AK
UT WOS:000345684300464
ER
PT J
AU Reiter, MJ
Schwope, RB
Lisanti, CJ
AF Reiter, Michael J.
Schwope, Ryan B.
Lisanti, Christopher J.
TI Algorithmic approach to solid adnexal masses and their mimics:
utilization of anatomic relationships and imaging features to facilitate
diagnosis
SO ABDOMINAL IMAGING
LA English
DT Article
DE Solid adnexal mass; Ovarian cancer; Uterine leiomyoma; US; CT; MRI
ID GASTROINTESTINAL STROMAL TUMORS; MULLERIAN DUCT ANOMALIES; NERVE SHEATH
TUMORS; GERM-CELL TUMORS; PELVIC MASSES; PATHOLOGICAL CORRELATION;
COMPUTED-TOMOGRAPHY; OVARIAN TERATOMAS; CT; MRI
AB Solid adnexal masses, while less common than their cystic counterparts, may present a challenge for radiologists given the wide range of histologic entities that occur in this region. Pelvic masses, especially when large, can seem overwhelming at first but application of an algorithmic approach allows for more confident assessment. This approach focuses first on the use of anatomic relationships and interactions of various pelvic structures to localize the mass' origin. For instance, the directionality of ureteral displacement can suggest if a mass is intra or extraperitoneal. Then, key discriminating imaging features, such as the presence of fat, hypervascularity, or low T2 signal on magnetic resonance imaging (MRI) can be applied to further narrow the list of diagnostic possibilities. Entities such as leiomyomas, nerve sheath tumors, congenital uterine anomalies, and vascular abnormalities (ovarian torsion or iliac vessel aneurysm) in particular are often accurately characterized with sonography and/or MRI. For solid adnexal masses in which a definitive diagnosis by imaging is not reached, information germane to clinicians regarding further management can still be provided, principally with regard to surgical vs. nonsurgical treatment.
C1 [Reiter, Michael J.; Schwope, Ryan B.; Lisanti, Christopher J.] Brooke Army Med Ctr, Dept Radiol, San Antonio, TX 78234 USA.
[Reiter, Michael J.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
RP Reiter, MJ (reprint author), Brooke Army Med Ctr, Dept Radiol, 3551 Roger Brooke Dr, San Antonio, TX 78234 USA.
EM mikereiter13@yahoo.com
NR 64
TC 1
Z9 1
U1 1
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0942-8925
EI 1432-0509
J9 ABDOM IMAGING
JI Abdom. Imaging
PD DEC
PY 2014
VL 39
IS 6
BP 1284
EP 1296
DI 10.1007/s00261-014-0163-4
PG 13
WC Gastroenterology & Hepatology; Radiology, Nuclear Medicine & Medical
Imaging
SC Gastroenterology & Hepatology; Radiology, Nuclear Medicine & Medical
Imaging
GA AT5SW
UT WOS:000345003100019
PM 24852312
ER
PT J
AU Bulzacchelli, MT
Sulsky, SI
Rodriguez-Monguio, R
Karlsson, LH
Hill, OT
AF Bulzacchelli, Maria T.
Sulsky, Sandra I.
Rodriguez-Monguio, Rosa
Karlsson, Lee H.
Hill, Owen T.
TI Injury During US Army Basic Combat Training A Systematic Review of Risk
Factor Studies
SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE
LA English
DT Review
ID EXERCISE-RELATED INJURIES; STRESS-FRACTURES; YOUNG MEN; MILITARY;
RECRUITS; PREVENTION; TRAINEES; INTERVENTIONS; WOMEN; RATES
AB Context: Approximately one quarter of men and half of women in U.S. Army basic combat training experience an injury. Preventing basic combat training-related injuries would reduce associated human and economic costs and discharges from the Army. Identification of risk factors for such injuries is a crucial step toward their prevention. Although some research has begun to address this need, prior studies of risk factors for training-related injury have not been reviewed systematically. This study systematically reviews the literature on risk factors for injury during U.S. Army basic combat training.
Evidence acquisition: Original studies of risk factors for injury during U.S. Army basic combat training published since 1990 in peer-reviewed journals were identified using PubMed and manual searches of reference lists. This search was last performed in May 2013. Nineteen studies met the inclusion criteria.
Evidence synthesis: Methodologic quality and potential for bias were assessed. The findings of 11 studies deemed to be of high or medium quality were synthesized to determine the level of evidence supporting the association between each risk factor studied and risk of injury during basic combat training. Quality assessment and evidence synthesis were performed from June to September 2013.
Conclusions: There is strong or moderate evidence supporting association of older age, history of smoking, and self-rated low physical activity level prior to basic combat training with increased risk of training-related injury among male trainees. There is limited, mixed, or insufficient evidence to identify risk factors for injury among female trainees. (C) 2014 American Journal of Preventive Medicine. All rights reserved.
C1 [Bulzacchelli, Maria T.; Rodriguez-Monguio, Rosa] Univ Massachusetts, Dept Publ Hlth, Amherst, MA 01003 USA.
[Sulsky, Sandra I.; Karlsson, Lee H.] ENVIRON Int Corp, Amherst, MA USA.
[Hill, Owen T.] US Army Res Inst Environm Med, Natick, MA USA.
RP Bulzacchelli, MT (reprint author), Univ Massachusetts, Dept Publ Hlth, 715 N Pleasant St, Amherst, MA 01003 USA.
EM bulzacchelli@schoolph.umass.edu
FU U.S. Army Medical Research Materiel Command [W911QY-10-C-0194]; U.S.
Army Research Institute of Environmental Medicine
FX This work was supported by the U.S. Army Medical Research Materiel
Command, under Contract No. W911QY-10-C-0194, in collaboration with the
U.S. Army Research Institute of Environmental Medicine.
NR 37
TC 6
Z9 6
U1 2
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0749-3797
EI 1873-2607
J9 AM J PREV MED
JI Am. J. Prev. Med.
PD DEC
PY 2014
VL 47
IS 6
BP 813
EP 822
DI 10.1016/j.amepre.2014.08.008
PG 10
WC Public, Environmental & Occupational Health; Medicine, General &
Internal
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA AT9RP
UT WOS:000345264200015
PM 25455122
ER
PT J
AU Saunders, D
Vanachayangkul, P
Imerbsin, R
Khemawoot, P
Siripokasupkul, R
Tekwani, BL
Sampath, A
Nanayakkara, NPD
Ohrt, C
Lanteri, C
Gettyacamin, M
Teja-Isavadharm, P
Walker, L
AF Saunders, David
Vanachayangkul, Pattaraporn
Imerbsin, Rawiwan
Khemawoot, Phisit
Siripokasupkul, Raveewan
Tekwani, Babu L.
Sampath, Aruna
Nanayakkara, N. P. Dhammika
Ohrt, Colin
Lanteri, Charlotte
Gettyacamin, Montip
Teja-Isavadharm, Paktiya
Walker, Larry
TI Pharmacokinetics and Pharmacodynamics of (+)-Primaquine and
(-)-Primaquine Enantiomers in Rhesus Macaques (Macaca mulatta)
SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
LA English
DT Article
ID PLACEBO-CONTROLLED TRIAL; PLASMODIUM-VIVAX MALARIA; MAJOR PLASMA
METABOLITE; PRIMAQUINE ENANTIOMERS; PROPHYLAXIS; DRUG;
8-AMINOQUINOLINES; CARBOXYPRIMAQUINE; METHEMOGLOBINEMIA; SUSCEPTIBILITY
AB Primaquine (PQ) remains the sole available drug to prevent relapse of Plasmodium vivax malaria more than 60 years after licensure. While this drug was administered as a racemic mixture, prior studies suggested a pharmacodynamic advantage based on differential antirelapse activity and/or toxicities of its enantiomers. Oral primaquine enantiomers prepared using a novel, easily scalable method were given for 7 days to healthy rhesus macaques in a dose-rising fashion to evaluate their effects on the blood, liver, and kidneys. The enantiomers were then administered to Plasmodium cynomolgi-infected rhesus macaques at doses of 1.3 and 0.6 mg/kg of body weight/day in combination with chloroquine. The (-)-PQ enantiomer had higher clearance and apparent volume of distribution than did (+)-PQ and was more extensively converted to the carboxy metabolite. There is evidence for differential oxidative stress with a concentration-dependent rise in methemoglobin (MetHgb) with increasing doses of (+)-PQ greater than that seen for (-)-PQ. There was a marked, reversible hepatotoxicity in 2 of 3 animals dosed with (-)-PQ at 4.5 mg/kg. (-)-PQ in combination with chloroquine was successful in preventing P. cynomolgi disease relapse at doses of 0.6 and 1.3 mg/kg/day, while 1 of 2 animals receiving (+)-PQ at 0.6 mg/kg/day relapsed. While (-)-PQ was also associated with hepatotoxicity at higher doses as seen previously, this has not been identified as a clinical concern in humans during >60 years of use. Limited evidence for increased MetHgb generation with the (+) form in the rhesus macaque model suggests that it may be possible to improve the therapeutic window for hematologic toxicity in the clinic by separating primaquine into its enantiomers.
C1 [Saunders, David; Vanachayangkul, Pattaraporn; Khemawoot, Phisit; Siripokasupkul, Raveewan; Lanteri, Charlotte; Teja-Isavadharm, Paktiya] Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand.
[Imerbsin, Rawiwan; Gettyacamin, Montip] Armed Forces Res Inst Med Sci, Dept Vet Med, Bangkok 10400, Thailand.
[Tekwani, Babu L.; Sampath, Aruna; Nanayakkara, N. P. Dhammika; Walker, Larry] Univ Mississippi, Natl Ctr Nat Prod Res, Oxford, MS USA.
[Tekwani, Babu L.; Walker, Larry] Univ Mississippi, Sch Pharm, Dept Pharmacol, Oxford, MS USA.
[Ohrt, Colin] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA.
RP Saunders, D (reprint author), Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand.
EM David.Saunders@AFRIMS.org
NR 32
TC 3
Z9 3
U1 3
U2 6
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0066-4804
EI 1098-6596
J9 ANTIMICROB AGENTS CH
JI Antimicrob. Agents Chemother.
PD DEC
PY 2014
VL 58
IS 12
BP 7283
EP 7291
DI 10.1128/AAC.02576-13
PG 9
WC Microbiology; Pharmacology & Pharmacy
SC Microbiology; Pharmacology & Pharmacy
GA AT9AW
UT WOS:000345221000030
PM 25267666
ER
PT J
AU Hawkins, AD
Thornton, C
Steevens, JA
Willett, KL
AF Hawkins, Adam D.
Thornton, Cammi
Steevens, Jeffery A.
Willett, Kristine L.
TI ALTERATION IN PIMEPHALES PROMELAS MUCUS PRODUCTION AFTER EXPOSURE TO
NANOSILVER OR SILVER NITRATE
SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
LA English
DT Article
DE Metal toxicology; Nanoparticles; Nanotoxicology; Silver
ID TROUT ONCORHYNCHUS-MYKISS; RAINBOW-TROUT; TOXICITY; FISH; POLLUTION;
STRESS; WATER
AB The fish gill's ability to produce mucus effectively is a critical part of the stress response and protection against xenobiotic toxicity. Adult fathead minnows were exposed to silver nitrate (0.82 mu g/L or 13.2 mu g/L), polyvinylpyrrolidone-coated silver nanoparticles (11.1 mu g/L or 208 mu g/L), and citrate-coated silver nanoparticles (10.1 mu g/L or 175 mu g/L) for 96h. Mucus concentrations based on glucose as a surrogate were determined at 0h, 1h, 2h, 3h, 4 h and 24h after re-dosing each day. Higher mucus production rates following silver treatment were observed at the beginning as compared to controls and compared to after 3d of exposure. Control fish produced consistent mucus concentrations throughout the exposure (0.62mg/L and 0.40mg/L at 24h and 96h, respectively). Following 24h of exposure, all silver treatment groups produced significantly more mucus than controls. Following 96h of exposure, mucus concentrations in treatment groups were significantly reduced compared with each respective treatment at 24h. Reduced mucus production following long-term silver exposure could prevent the gills from removing silver, and thus increase toxicity. Environ Toxicol Chem 2014;33:2869-2872. (c) 2014 SETAC
C1 [Hawkins, Adam D.; Thornton, Cammi; Willett, Kristine L.] Univ Mississippi, Sch Pharm, Dept BioMol Sci, University, MS 38677 USA.
[Hawkins, Adam D.; Thornton, Cammi; Willett, Kristine L.] Univ Mississippi, Sch Pharm, Environm Toxicol Res Program, University, MS 38677 USA.
[Steevens, Jeffery A.] US Army, Environm Lab, Engn Res & Dev Ctr, Vicksburg, MS USA.
RP Willett, KL (reprint author), Univ Mississippi, Sch Pharm, Dept BioMol Sci, University, MS 38677 USA.
EM kwillett@olemiss.edu
RI Geracitano, Laura/E-6926-2013
FU Army Corp of Engineers Engineer Research and Development Center
[W912HZ-09-C-0033]
FX We would like to thank F. Booc and K. Alharthy for assistance with water
changes, feedings, and water sample collection, and A. Bednar for help
with inductively coupled plasma-mass spectrometry analyses. This
research is supported by Army Corp of Engineers Engineer Research and
Development Center funding (#W912HZ-09-C-0033).
NR 23
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Z9 2
U1 2
U2 11
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0730-7268
EI 1552-8618
J9 ENVIRON TOXICOL CHEM
JI Environ. Toxicol. Chem.
PD DEC
PY 2014
VL 33
IS 12
BP 2869
EP 2872
DI 10.1002/etc.2759
PG 4
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA AU0NE
UT WOS:000345319100028
PM 25262928
ER
PT J
AU McAllister, QP
Gillespie, JW
VanLandingham, MR
AF McAllister, Quinn P.
Gillespie, John W., Jr.
VanLandingham, Mark R.
TI The energy dissipative mechanisms of particle-fiber interactions in a
textile composite
SO JOURNAL OF COMPOSITE MATERIALS
LA English
DT Article
DE Kevlar; nanoindentation; nanoscratching; energy dissipation; textile
composite
ID FRAGMENT-CONTAINMENT APPLICATIONS; THICKENING-FLUID KEVLAR; BALLISTIC
IMPACT ENERGY; YARN PULL-OUT; HIGH-STRENGTH; WOVEN FABRICS; TRANSVERSE
COMPRESSION; ARAMID FABRICS; SINGLE-FIBER; PPTA FIBERS
AB Nanoindentation and nanoscratch tests made on the surface of Kevlar KM2 fibers impart contact geometries similar to a typical contact between a particle and a fiber in a particle-infused fabric. In this study, the forces required for indentation and scratching are used as a measure of a single particle gouge of the surface of a Kevlar fiber. The gouging forces and a geometric model are used to calculate the apparent friction and energy associated with particle gouging during impact. The friction associated with particle gouging can be increased up to approximate to 240% compared to Kevlar yarn-yarn friction levels. The energy of gouging a distribution of particles is on the order of 10% of the energy required for axial tensile failure and 25% of the energy required for transverse compression of the fiber (for a limiting transverse strain of approximate to 0.3). The relative contributions of the friction and energy associated with particle gouging to the overall energy dissipated by a textile composite are discussed.
C1 [McAllister, Quinn P.; Gillespie, John W., Jr.] Univ Delaware, Ctr Composite Mat, Dept Mat Sci & Engn, Newark, DE 19716 USA.
[Gillespie, John W., Jr.] Univ Delaware, Dept Civil & Environm Engn, Newark, DE 19716 USA.
[Gillespie, John W., Jr.] Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA.
[VanLandingham, Mark R.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD USA.
RP McAllister, QP (reprint author), Univ Delaware, Ctr Composite Mat, Dept Mat Sci & Engn, Newark, DE 19716 USA.
EM mcallq@gmail.com
FU Army Research Laboratory [W911NF-06-2-0011, W911NF-12-2-0022]
FX Research was sponsored by the Army Research Laboratory and was
accomplished under Cooperative Agreement Numbers W911NF-06-2-0011 and
W911NF-12-2-0022.
NR 46
TC 0
Z9 0
U1 3
U2 27
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0021-9983
EI 1530-793X
J9 J COMPOS MATER
JI J. Compos Mater.
PD DEC
PY 2014
VL 48
IS 28
BP 3553
EP 3567
DI 10.1177/0021998313511651
PG 15
WC Materials Science, Composites
SC Materials Science
GA AU0TH
UT WOS:000345336900009
ER
PT J
AU Harris, JT
Segall, AE
Robinson, D
Carter, R
AF Harris, J. T.
Segall, A. E.
Robinson, D.
Carter, R.
TI Interfacial Flaw Evolution of Coatings Under Severe Thermal and Pressure
Transients
SO JOURNAL OF PRESSURE VESSEL TECHNOLOGY-TRANSACTIONS OF THE ASME
LA English
DT Article
DE transient; thermal stress and strain; cylinder; cohesive zone
ID BARRIER COATINGS; THERMOMECHANICAL CRACKING; DAMAGE; DELAMINATION;
MECHANISMS; SUBSTRATE
AB The effects of severe thermal and pressure transients on coated substrates with indentation-induced, blister defects were analyzed by experimental and finite element methods. Cohesive zone properties evaluated in a previous study were first used in an implicit indentation simulation. Indentation simulation results then served as the initial conditions for explicit modeling of interfacial flaw evolution due to the already determined thermal and pressure transients that included interstitial pressure in the defect. The thermal structural model was used to assess the transient thermal-and stress-states and the propensity for fracture related damage and evolution while undergoing severe convective heating and pressure loading analogous to gun tube conditions. Results illustrated the overall benefits of the in-phase applied pressure in terms of suppressing crack growth except when delayed interstitial loading was considered. Thermal capacitance was also studied and it was found that crack growth decreased significantly with higher specific heat and demonstrates the potential importance of coating thermophysical properties.
C1 [Harris, J. T.; Segall, A. E.; Robinson, D.] Penn State Univ, University Pk, PA 16803 USA.
[Carter, R.] US Army Res Lab, AMSRL WM MB, Aberdeen Proving Ground, MD 21005 USA.
RP Harris, JT (reprint author), Penn State Univ, 212 EES Bldg, University Pk, PA 16803 USA.
EM jth203@psu.edu; aesegall@psu.edu; rcarter@arl.army.mil
FU Army Research Lab at the Department of Defense
FX The authors would like to acknowledge the Army Research Lab at the
Department of Defense for the funding that made this work possible.
NR 22
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U1 2
U2 5
PU ASME
PI NEW YORK
PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA
SN 0094-9930
EI 1528-8978
J9 J PRESS VESS-T ASME
JI J. Press. Vessel Technol.-Trans. ASME
PD DEC
PY 2014
VL 136
IS 6
AR 061205
DI 10.1115/1.4025721
PG 8
WC Engineering, Mechanical
SC Engineering
GA AT8AD
UT WOS:000345155300005
ER
PT J
AU Naito, C
Beacraft, M
Hoemann, J
Shull, J
Salim, H
Bewick, B
AF Naito, Clay
Beacraft, Mark
Hoemann, John
Shull, Jonathan
Salim, Hani
Bewick, Bryan
TI Blast Performance of Single-Span Precast Concrete Sandwich Wall Panels
SO JOURNAL OF STRUCTURAL ENGINEERING
LA English
DT Article
DE Blasting; Sandwich panels; Prestressed concrete; Composite beams;
Dynamic tests; Sandwich panels; Prestressed concrete; Composite beams;
Dynamic tests; Shock and vibratory effects
AB A research program was conducted to assess the capability of conventional non-load-bearing insulated precast concrete exterior wall panels to withstand blast loadings. Typical construction details from the tilt-up and prestressed concrete industries were examined. The sensitivity of insulation type, reinforcement, foam thickness, and shear tie type on the flexural resistance was assessed. Forty-two single-span static experiments were conducted on 14 different panel designs. From the results of these experiments, resistance functions and deformation limits for insulated concrete sandwich panels were determined. The resistance functions were used to develop predictive dynamic models for panels subjected to blast demands. The models were found to be accurate in comparison to measurements from four full-scale blast detonations. The findings of the research indicate that both prestressed and non-prestressed insulated concrete wall panels meet current rotational limits defined by the U.S. Army Corps of Engineers for protective structures. Simplified methods for modeling the pressure-deformation characteristics of insulated panels can be used to approximate the peak dynamic deformation and reaction loads.
C1 [Naito, Clay; Beacraft, Mark] Lehigh Univ, Dept Civil & Environm Engn, ATLSS Ctr, Bethlehem, PA 18015 USA.
[Hoemann, John] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Hoemann, John] Air Force Res Lab, Tyndall AFB, FL USA.
[Hoemann, John] Appl Res Associates Inc, Tyndall AFB, FL USA.
[Shull, Jonathan] Black & Veatch Consulting Engineers, Fed Serv Div, Webb City, MO 64870 USA.
[Salim, Hani] Univ Missouri, Dept Civil & Environm Engn, Columbia, MO 65211 USA.
[Bewick, Bryan] Protect Engn Consultants, Austin, TX 78737 USA.
[Bewick, Bryan] Air Force Res Lab, Panama City, FL 32403 USA.
RP Naito, C (reprint author), Lehigh Univ, Dept Civil & Environm Engn, ATLSS Ctr, 117 ATLSS Dr, Bethlehem, PA 18015 USA.
EM cjn3@lehigh.edu; mark.beacraft@gmail.com
OI Naito, Clay/0000-0003-3835-8131
FU Air Force Research Laboratory [FA4918-07-D-0001, FA8903-08-D-8768]
FX The authors thank the Air Force Research Laboratory (Dr. Robert Dinan
and Dr. Michael Hammons, Program Managers) for funding this work under
contracts FA4918-07-D-0001 and FA8903-08-D-8768. The experiments were
performed at the Air Force Research Laboratory located at Tyndall AFB,
FL, and at the University of Missouri - Columbia. The work was conducted
under a Cooperative Research and Development Agreement (CRADA) between
the Portland Cement Association, the Prestressed/Precast Concrete
Institute, and the Tilt-Up Concrete Association. The authors also thank
John Sullivan, Jason Krohn, Michael Sugrue, and the member companies of
these organizations for technical and fabrication support of the
research. In addition, the authors thank the Geotechnical and Structures
Laboratory of the U.S. Army Corps of Engineers for efforts in revising
this document. Citation of manufacturers or trade names does not
constitute an official endorsement or approval of the use thereof. The
U.S. Government is authorized to reproduce and distribute reprints for
Government purposes notwithstanding any copyright notation hereon.
NR 17
TC 1
Z9 1
U1 4
U2 30
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0733-9445
EI 1943-541X
J9 J STRUCT ENG
JI J. Struct. Eng.
PD DEC
PY 2014
VL 140
IS 12
AR 04014096
DI 10.1061/(ASCE)ST.1943-541X.0001020
PG 13
WC Construction & Building Technology; Engineering, Civil
SC Construction & Building Technology; Engineering
GA AU0RE
UT WOS:000345330900005
ER
PT J
AU Scalzitti, NJ
Pfannenstiel, TJ
AF Scalzitti, Nicholas J.
Pfannenstiel, Travis J.
TI A Lightning Strike Causing a Cholesteatoma: A Unique Form of Otologic
Blast Injury
SO OTOLOGY & NEUROTOLOGY
LA English
DT Article
DE Blast injury; Cholesteatoma; Lightening
ID TYMPANIC MEMBRANE; RARE-CAUSE; OVERPRESSURE; DISRUPTION; EAR
AB Objective: We present a case of a middle-aged male struck by lightning while walking in a parking lot. Assessment of the patient's injuries demonstrated common sequelae of an otologic blast injury. Review of this case should prepare the otolaryngologist to identify and manage otologic blast injuries regardless of their etiology.
Methods: Case study and literature review
Case Report: The patient presented to a level 1 trauma and burn center with a ruptured tympanic membrane, otalgia, mixed hearing loss, dizziness, and tinnitus. After 3 months of observation, the patient's tympanic membrane perforation demonstrated little spontaneous closure. Additionally, he was noted to have formation of a posttraumatic cholesteatoma in the posterior-superior mesotympanum. Over-under tympanoplasty with excision of the cholesteatoma was successful, and the ossicular chain remained intact. The patient underwent vestibular therapy for an ipsilateral uncompensated vestibular weakness. His dizziness resolved, allowing him to return to full employment. The patient's final audiogram demonstrated normal hearing thresholds sloping to a mild mixed hearing loss in the high frequencies, and the tinnitus reduced significantly in intensity but did not resolve.
Conclusion: The patient's injury pattern clearly resulted from the damaging effects of the shock wave generated by the lightning bolt, which impacted the patient's thorax. Management of his otologic care was conducted after practices developed for otologic blast injury and resulted in his being able to return to his primary occupation.
C1 [Scalzitti, Nicholas J.; Pfannenstiel, Travis J.] Brooke Army Med Ctr, San Antonio, TX USA.
RP Scalzitti, NJ (reprint author), JBSA Ft Sam, Dept Otolaryngol, 3551 Roger Brooke Dr, Houston, TX 78264 USA.
EM nicholas.j.sclazitti.mil@mail.mil
NR 9
TC 0
Z9 0
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1531-7129
EI 1537-4505
J9 OTOL NEUROTOL
JI Otol. Neurotol.
PD DEC
PY 2014
VL 35
IS 10
BP E298
EP E300
PG 3
WC Clinical Neurology; Otorhinolaryngology
SC Neurosciences & Neurology; Otorhinolaryngology
GA AT8AX
UT WOS:000345157200006
PM 25111525
ER
PT J
AU Nenno, PT
Wetzel, ED
AF Nenno, Paul T.
Wetzel, Eric D.
TI Design and properties of a rate-dependent 'dynamic ligament' containing
shear thickening fluid
SO SMART MATERIALS AND STRUCTURES
LA English
DT Article
DE shear thickening fluid; dynamic ligament; rate-dependent
ID COLLOIDAL DISPERSIONS; BALLISTIC PERFORMANCE; BROWNIAN SUSPENSIONS;
DENSE SUSPENSIONS; PARTICLE-SIZE; RHEOLOGY; FORCES
AB A 'dynamic ligament' device that exhibits a discontinuous, rate-dependent tensile response is developed and characterized. The device, based on a shear thickening fluid (STF) and flexible ribbons enclosed in elastomeric tubing, exhibits low resistance to extension at rates below 10 mm s(-1), but when stretched at 100 mm s(-1) or higher resists with more than tenfold higher force. A link between the rheology of the STF and the tensile performance of the dynamic ligament is presented to explain the rate-dependent response. Visualization experiments show evidence of void formation and dilation in the STF during high rate extension.
C1 [Nenno, Paul T.; Wetzel, Eric D.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Nenno, PT (reprint author), US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM eric.d.wetzel2.civ@mail.mil
FU Oak Ridge Institute for Science and Education; Defense Advanced Research
Projects Agency (DARPA) under the Warrior Web program (PI: LTC Joseph
Hitt)
FX This research was supported in part by an appointment to the
Postgraduate Research Participation Program at the US Army Research
Laboratory administered by the Oak Ridge Institute for Science and
Education through an interagency agreement between the US Department of
Energy and ARL. Seed funding to initiate the research was provided by
the Defense Advanced Research Projects Agency (DARPA) under the Warrior
Web program (PI: LTC Joseph Hitt). The authors also acknowledge
supporting contributions from Anthony Pallanta, Dr Jeremy Fowler and
Professor Norman Wagner at the University of Delaware.
NR 31
TC 1
Z9 2
U1 0
U2 17
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0964-1726
EI 1361-665X
J9 SMART MATER STRUCT
JI Smart Mater. Struct.
PD DEC
PY 2014
VL 23
IS 12
AR 125019
DI 10.1088/0964-1726/23/12/125019
PG 10
WC Instruments & Instrumentation; Materials Science, Multidisciplinary
SC Instruments & Instrumentation; Materials Science
GA AT9WU
UT WOS:000345275400020
ER
PT J
AU Zhang, H
Cho, K
Yen, CF
Ravi-Chandar, K
AF Zhang, H.
Cho, K.
Yen, C. F.
Ravi-Chandar, K.
TI Dynamic Crushing of Unidirectionally Reinforced Metal Matrix Composite
SO STRAIN
LA English
DT Article
DE dissipation; Hopkinson bar; kink band
ID COMPRESSIVE FAILURE; FIBER COMPOSITES; ALUMINUM
AB The strain rate-dependent response of Al2O3/Al composite is examined using a split-Hopkinson pressure bar apparatus. High-speed photography is used to establish that the strain develops inhomogeneously in the specimen due to the onset and propagation of a kink band. The power balance equation is exploited in order to determine the dissipation at the kink band. The mechanism of kink band is shown to be essentially unaltered, with only the amount of fibre fracture being influenced by the dynamic loading process.
C1 [Zhang, H.] Schlumberger, Sugar Land, TX 77478 USA.
[Cho, K.; Yen, C. F.] Army Res Lab, Aberdeen, MD USA.
[Ravi-Chandar, K.] Univ Texas Austin, Ctr Mech Solids Struct & Mat, Austin, TX 78712 USA.
RP Zhang, H (reprint author), Schlumberger, Sugar Land, TX 77478 USA.
FU Army Research Office [W911NF-09-1-0331]
FX This work was performed under a grant from the Army Research Office
under grant number W911NF-09-1-0331. This support is gratefully
acknowledged.
NR 13
TC 0
Z9 0
U1 3
U2 7
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1475-1305
J9 STRAIN
JI Strain
PD DEC
PY 2014
VL 50
IS 6
SI SI
BP 517
EP 526
DI 10.1111/str.12103
PG 10
WC Materials Science, Characterization & Testing
SC Materials Science
GA AT3YT
UT WOS:000344872600004
ER
PT J
AU Wallace, RM
Stanek, D
Griese, S
Krulak, D
Vora, NM
Pacha, L
Kan, V
Said, M
Williams, C
Burgess, TH
Clausen, SS
Austin, C
Gabel, J
Lehman, M
Finelli, LN
Selvaggi, G
Joyce, P
Gordin, F
Benator, D
Bettano, A
Cersovsky, S
Blackmore, C
Jones, SV
Buchanan, BD
Fernandez, AI
Dinelli, D
Agnes, K
Clark, A
Gill, J
Irmler, M
Blythe, D
Mitchell, K
Whitman, TJ
Zapor, MJ
Zorich, S
Witkop, C
Jenkins, P
Mora, P
Droller, D
Turner, S
Dunn, L
Williams, P
Richards, C
Ewing, G
Chapman, K
Corbitt, C
Girimont, T
Franka, R
Recuenco, S
Blanton, JD
Feldman, KA
AF Wallace, R. M.
Stanek, D.
Griese, S.
Krulak, D.
Vora, N. M.
Pacha, L.
Kan, V.
Said, M.
Williams, C.
Burgess, T. H.
Clausen, S. S.
Austin, C.
Gabel, J.
Lehman, M.
Finelli, L. N.
Selvaggi, G.
Joyce, P.
Gordin, F.
Benator, D.
Bettano, A.
Cersovsky, S.
Blackmore, C.
Jones, S. V.
Buchanan, B. D.
Fernandez, A. I.
Dinelli, D.
Agnes, K.
Clark, A.
Gill, J.
Irmler, M.
Blythe, D.
Mitchell, K.
Whitman, T. J.
Zapor, M. J.
Zorich, S.
Witkop, C.
Jenkins, P.
Mora, P.
Droller, D.
Turner, S.
Dunn, L.
Williams, P.
Richards, C.
Ewing, G.
Chapman, K.
Corbitt, C.
Girimont, T.
Franka, R.
Recuenco, S.
Blanton, J. D.
Feldman, K. A.
TI A Large-scale, Rapid Public Health Response to Rabies in an Organ
Recipient and the Previously Undiagnosed Organ Donor
SO ZOONOSES AND PUBLIC HEALTH
LA English
DT Article
ID POSTEXPOSURE PROPHYLAXIS; CARE-WORKERS; TRANSPLANT RECIPIENTS;
UNITED-STATES; TRANSMISSION; PREVENTION; VIRUS; RISK
AB This article describes and contrasts the public health response to two human rabies cases: one organ recipient diagnosed within days of symptom onset and the transplant donor who was diagnosed 18months post-symptom onset. In response to an organ-transplant-related rabies case diagnosed in 2013, organ donor and recipient investigations were conducted by multiple public health agencies. Persons with potential exposure to infectious patient materials were assessed for rabies virus exposure. An exposure investigation was conducted to determine the source of the organ donor's infection. Over 100 persons from more than 20 agencies spent over 2700h conducting contact investigations in healthcare, military and community settings. The 564 persons assessed include 417 healthcare workers [5.8% recommended for post-exposure prophylaxis (PEP)], 96 community contacts (15.6% recommended for PEP), 30 autopsy personnel (50% recommended for PEP), and 21 other persons (4.8% recommended for PEP). Donor contacts represented 188 assessed with 20.2% recommended for PEP, compared with 5.6% of 306 recipient contacts recommended for PEP. Human rabies cases result in substantial use of public health and medical resources, especially when diagnosis is delayed. Although rare, clinicians should consider rabies in cases of encephalitis of unexplained aetiology, particularly for cases that may result in organ donation.
C1 [Wallace, R. M.; Vora, N. M.; Franka, R.; Recuenco, S.; Blanton, J. D.] Ctr Dis Control & Prevent, Poxvirus & Rabies Branch, DHCPP, Atlanta, GA 30333 USA.
[Wallace, R. M.; Griese, S.; Vora, N. M.; Said, M.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA 30333 USA.
[Stanek, D.; Blackmore, C.] Florida Dept Hlth, Tallahassee, FL USA.
[Griese, S.; Williams, C.] North Carolina Dept Hlth, Raleigh, NC USA.
[Krulak, D.; Jones, S. V.; Buchanan, B. D.; Fernandez, A. I.; Dinelli, D.] Naval Hosp Pensacola, Pensacola, FL USA.
[Pacha, L.; Cersovsky, S.] US Army Publ Hlth Command, Aberdeen Proving Ground, MD USA.
[Kan, V.; Joyce, P.; Gordin, F.; Benator, D.; Agnes, K.; Clark, A.; Gill, J.; Irmler, M.] Washington DC Vet Affairs Med Ctr, Washington, DC USA.
[Kan, V.; Gordin, F.; Benator, D.] George Washington Univ, Washington, DC USA.
[Said, M.; Blythe, D.; Mitchell, K.; Feldman, K. A.] Maryland Dept Hlth & Mental Hyg, Baltimore, MD USA.
[Burgess, T. H.; Clausen, S. S.; Whitman, T. J.; Zapor, M. J.] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA.
[Austin, C.] Illinois Dept Publ Hlth, Springfield, IL 62761 USA.
[Gabel, J.] Georgia Dept Hlth, Atlanta, GA USA.
[Lehman, M.; Bettano, A.; Zorich, S.] US Air Force Sch Aerosp Med, Dayton, OH USA.
[Finelli, L. N.] Off Armed Forces Med Examiner, Dover, DE USA.
[Selvaggi, G.; Mora, P.; Droller, D.] Broward Cty Hosp, Broward, FL USA.
[Witkop, C.] Air Force Med Support Agcy, Dayton, OH USA.
[Jenkins, P.] Florida Dept Hlth Broward Cty, Ft Lauderdale, FL USA.
[Turner, S.; Dunn, L.; Williams, P.; Richards, C.] Florida Dept Hlth Escambia Cty, Pensacola, FL USA.
[Ewing, G.] Sacred Heart Hosp, Pensacola, FL USA.
[Chapman, K.] Okaloosa Cty Hlth Dept, Ft Walton Beach, FL USA.
[Corbitt, C.] LifeQuest, Pensacola, FL USA.
[Girimont, T.] Shands Transplant Ctr, Shands Transplant Lab, Gainesville, FL USA.
RP Wallace, RM (reprint author), Ctr Dis Control & Prevent, Poxvirus & Rabies Branch, DHCPP, 1600 Clifton Rd,Mailstop G-33, Atlanta, GA 30333 USA.
EM EUK5@cdc.gov
OI Recuenco-Cabrera, Sergio/0000-0002-8446-7411
NR 32
TC 3
Z9 3
U1 0
U2 5
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1863-1959
EI 1863-2378
J9 ZOONOSES PUBLIC HLTH
JI Zoonoses Public Health
PD DEC
PY 2014
VL 61
IS 8
BP 560
EP 570
DI 10.1111/zph.12105
PG 11
WC Public, Environmental & Occupational Health; Infectious Diseases;
Veterinary Sciences
SC Public, Environmental & Occupational Health; Infectious Diseases;
Veterinary Sciences
GA AU0LI
UT WOS:000345313800005
PM 24673934
ER
PT J
AU Margolis, LM
Murphy, NE
Martini, S
Spitz, MG
Thrane, I
McGraw, SM
Blatny, JM
Castellani, JW
Rood, JC
Young, AJ
Montain, SJ
Gundersen, Y
Pasiakos, SM
AF Margolis, Lee M.
Murphy, Nancy E.
Martini, Svein
Spitz, Marissa G.
Thrane, Ingjerd
McGraw, Susan M.
Blatny, Janet-Martha
Castellani, John W.
Rood, Jennifer C.
Young, Andrew J.
Montain, Scott J.
Gundersen, Yngvar
Pasiakos, Stefan M.
TI Effects of winter military training on energy balance, whole-body
protein balance, muscle damage, soreness, and physical performance
SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
LA English
DT Article
DE nitrogen; dietary protein; recommended dietary allowance; stress
ID DOUBLY LABELED WATER; EXERCISE; TURNOVER; EXPENDITURE; VALIDATION;
METABOLISM; PERSONNEL; NITROGEN; LEUCINE; DIETS
AB Physiological consequences of winter military operations are not well described. This study examined Norwegian soldiers (n = 21 males) participating in a physically demanding winter training program to evaluate whether short-term military training alters energy and whole-body protein balance, muscle damage, soreness, and performance. Energy expenditure ((D2O)-O-18) and intake were measured daily, and postabsorptive whole-body protein turnover ([N-15]-glycine), muscle damage, soreness, and performance (vertical jump) were assessed at baseline, following a 4-day, military task training phase (MTT) and after a 3-day, 54-km ski march (SKI). Energy intake (kcal.day(-1)) increased (P < 0.01) from (mean +/- SD (95% confidence interval)) 3098 +/- 236 (2985, 3212) during MTT to 3461 +/- 586 (3178, 3743) during SKI, while protein (g.kg(-1).day(-1)) intake remained constant (MTT, 1.59 +/- 0.33 (1.51, 1.66); and SKI, 1.71 +/- 0.55 (1.58, 1.85)). Energy expenditure increased (P < 0.05) during SKI (6851 +/- 562 (6580, 7122)) compared with MTT (5480 +/- 389 (5293, 5668)) and exceeded energy intake. Protein flux, synthesis, and breakdown were all increased (P < 0.05) 24%, 18%, and 27%, respectively, during SKI compared with baseline and MTT. Whole-body protein balance was lower (P < 0.05) during SKI (-1.41 +/- 1.11 (-1.98, -0.84) g.kg(-1).10 h) than MTT and baseline. Muscle damage and soreness increased and performance decreased progressively (P < 0.05). The physiological consequences observed during short-term winter military training provide the basis for future studies to evaluate nutritional strategies that attenuate protein loss and sustain performance during severe energy deficits.
C1 [Margolis, Lee M.; Murphy, Nancy E.; McGraw, Susan M.; Young, Andrew J.; Montain, Scott J.; Pasiakos, Stefan M.] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA.
[Martini, Svein; Thrane, Ingjerd; Blatny, Janet-Martha; Gundersen, Yngvar] Norwegian Def Res Estab, N-2007 Kjeller, Norway.
[Spitz, Marissa G.; Castellani, John W.] US Army Res Inst Environm Med, Thermal Mt & Med Div, Natick, MA 01760 USA.
[Rood, Jennifer C.] Louisiana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA.
RP Pasiakos, SM (reprint author), US Army Res Inst Environm Med, Mil Nutr Div, 15 Kansas St,Bldg 42, Natick, MA 01760 USA.
EM stefan.m.pasiakos.civ@mail.mil
RI Pasiakos, Stefan/E-6295-2014;
OI Pasiakos, Stefan/0000-0002-5378-5820; , Lee/0000-0002-0652-1304
FU US Army Medical Research and Material Command; Norwegian Defence
Research Establishment [W81XWH-12-0279]
FX The authors thank the soldiers that participated in this research
experiment, the command, and training staff at the Garrison in
Sor-Varanger (Kirkenes, Norway) for their support of this study. The
investigators adhered to the policies for protection of human subjects
as prescribed in Army Regulation 70-25, and the research was conducted
in adherence with the provisions of 32 CFR part 219. The opinions or
assertions contained herein are the private views of the authors and are
not to be construed as official or as reflecting the views of the Army
or the Department of Defense. Any citations of commercial organizations
and trade names in this report do not constitute an official Department
of the Army endorsement of approval of the products or services of these
organizations. This work was supported by the US Army Medical Research
and Material Command and the Norwegian Defence Research Establishment,
under agreement no. W81XWH-12-0279.
NR 33
TC 7
Z9 7
U1 1
U2 3
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 1715-5312
EI 1715-5320
J9 APPL PHYSIOL NUTR ME
JI Appl. Physiol. Nutr. Metab.
PD DEC
PY 2014
VL 39
IS 12
BP 1395
EP 1401
DI 10.1139/apnm-2014-0212
PG 7
WC Nutrition & Dietetics; Physiology; Sport Sciences
SC Nutrition & Dietetics; Physiology; Sport Sciences
GA AS9FJ
UT WOS:000344548200011
PM 25386980
ER
PT J
AU Doty, TJ
Japee, S
Ingvar, M
Ungerleider, LG
AF Doty, Tracy J.
Japee, Shruti
Ingvar, Martin
Ungerleider, Leslie G.
TI Intersubject variability in fearful face processing: the link between
behavior and neural activation
SO COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE
LA English
DT Article
DE Emotion; Fearful faces; Ventromedial prefrontal cortex; Subgenual
cingulate cortex; Striatum; Affective value
ID VENTROMEDIAL PREFRONTAL CORTEX; EMOTIONAL FACIAL EXPRESSIONS;
EXPERIMENTALLY INDUCED ANXIETY; HUMAN AMYGDALA; FUNCTIONAL CONNECTIVITY;
INDIVIDUAL-DIFFERENCES; PREDICTION ERRORS; VISUAL AWARENESS; ATTENTIONAL
BIAS; SKIN-CONDUCTANCE
AB Stimuli that signal threat show considerable variability in the extents to which they enhance behavior, even among healthy individuals. However, the neural underpinning of this behavioral variability is not well understood. By manipulating expectation of threat in an fMRI study of fearful versus neutral face categorization, we uncovered a network of areas underlying variability in threat processing in healthy adults. We explicitly altered expectations by presenting face images at three different expectation levels: 80 %, 50 %, and 20 %. Subjects were instructed to report as quickly and accurately as possible whether the face was fearful (signaled threat) or not. An uninformative cue preceded each face by 4 s. By taking the difference between reaction times (RTs) to fearful and neutral faces, we quantified an overall fear RT bias (i.e., faster to fearful than to neutral faces) for each subject. This bias correlated positively with late-trial fMRI activation (8 s after the face) during unexpected-fearful-face trials in bilateral ventromedial prefrontal cortex, the left subgenual cingulate cortex, and the right caudate nucleus, and correlated negatively with early-trial fMRI activation (4 s after the cue) during expected-neutral-face trials in bilateral dorsal striatum and the right ventral striatum. These results demonstrate that the variability in threat processing among healthy adults is reflected not only in behavior, but also in the magnitude of activation in medial prefrontal and striatal regions that appear to encode affective value.
C1 [Doty, Tracy J.; Japee, Shruti; Ungerleider, Leslie G.] NIMH, Lab Brain & Cognit, Bethesda, MD 20892 USA.
[Doty, Tracy J.; Ingvar, Martin] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.
[Doty, Tracy J.] US Army Res Lab, Translat Neurosci Branch, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA.
RP Doty, TJ (reprint author), US Army Res Lab, Translat Neurosci Branch, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA.
EM tracy.doty@alumni.duke.edu
OI Doty, Tracy/0000-0001-9921-2457; Ingvar, Martin/0000-0002-9041-5714
FU Intramural NIH HHS [ZIA MH002035-33]
NR 68
TC 6
Z9 6
U1 5
U2 16
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1530-7026
EI 1531-135X
J9 COGN AFFECT BEHAV NE
JI Cogn. Affect. Behav. Neurosci.
PD DEC
PY 2014
VL 14
IS 4
BP 1438
EP 1453
DI 10.3758/s13415-014-0290-y
PG 16
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA AT0TP
UT WOS:000344648000020
PM 24841078
ER
PT J
AU Cap, A
Hunt, B
AF Cap, Andrew
Hunt, Beverley
TI Acute traumatic coagulopathy
SO CURRENT OPINION IN CRITICAL CARE
LA English
DT Review
DE acute traumatic coagulopathy; endothelial activation; fibrinolysis;
hemostatic resuscitation; hypoperfusion; microparticles; platelet
dysfunction; tranexamic acid; viscoelastic coagulation monitoring
ID ACTIVATED PROTEIN-C; DISSEMINATED INTRAVASCULAR COAGULATION;
LIFE-THREATENING HEMORRHAGE; FRESH WHOLE-BLOOD; 1ST 24 HOURS; MASSIVE
TRANSFUSION; TRANEXAMIC ACID; HEMOSTATIC RESUSCITATION; SEVERE INJURY;
MAJOR TRAUMA
AB Purpose of review
Mortality from trauma remains a global public health challenge, with most preventable deaths due to bleeding. The recognition of acute traumatic coagulopathy as a distinct clinical entity characterized by early coagulation dysfunction, arising prior to medical intervention, has revolutionized trauma management over the last decade. The aim of this article is to review our current understanding of acute traumatic coagulopathy.
Recent findings
We focus on recent advances in the mechanistic understanding of acute traumatic coagulopathy, particularly the changes in coagulation factors, physiological anticoagulants, endothelial activation, fibrinolysis and platelet dysfunction. Evolving diagnostic and therapeutic approaches are discussed, including viscoelastic coagulation monitoring and the role of tranexamic acid and blood products.
Summary
Emphasis is now placed on early prevention, diagnosis, and aggressive initial treatment of coagulopathy and fibrinolysis with haemostatic blood products and tranexamic acid in addition to red cell units in order to reduce bleeding and improve clinical outcomes.
C1 [Cap, Andrew] Uniformed Serv Univ Hlth Sci, US Army, Blood Res Program, Inst Surg Res,JBSA FT Sam Houston, San Antonio, TX USA.
[Hunt, Beverley] St Thomas Hosp, Dept Haematol, London SE1 7EH, England.
[Hunt, Beverley] Dept Pathol, London SE1 7EH, England.
[Hunt, Beverley] Lupus Guys & St Thomas NHS Fdn Trust, London SE1 7EH, England.
RP Hunt, B (reprint author), St Thomas Hosp, Dept Haematol, Westminster Bridge Rd, London SE1 7EH, England.
EM Beverley.Hunt@gstt.nhs.uk
NR 95
TC 8
Z9 9
U1 0
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1070-5295
EI 1531-7072
J9 CURR OPIN CRIT CARE
JI Curr. Opin. Crit. Care
PD DEC
PY 2014
VL 20
IS 6
BP 638
EP 645
DI 10.1097/MCC.0000000000000158
PG 8
WC Critical Care Medicine
SC General & Internal Medicine
GA AS8XS
UT WOS:000344529000009
PM 25340382
ER
PT J
AU Sousa, JC
Milner, E
Carroll, D
McCalmont, W
Gardner, S
Moon, J
Johnson, JD
Lee, P
Auschwitz, J
Roncal, N
Caridha, D
Tungteung, A
Zeng, Q
Reyes, S
Smith, B
Li, QG
Kozar, MP
Melendez, V
Dow, G
AF Sousa, Jason C.
Milner, Erin
Carroll, Dustin
McCalmont, William
Gardner, Sean
Moon, Jay
Johnson, Jacob D.
Lee, Patricia
Auschwitz, Jennifer
Roncal, Norma
Caridha, Diana
Tungteung, Anchalee
Zeng, Qiang
Reyes, Sean
Smith, Bryan
Li, Qigui
Kozar, Michael P.
Melendez, Victor
Dow, Geoffrey
TI The use of a prodrug approach to minimize potential CNS exposure of next
generation quinoline methanols while maintaining efficacy in in vivo
animal models
SO EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
LA English
DT Article
DE Malaria; Mefloquine; Quinoline methanol; Blood-brain barrier; Central
nervous system; Prodrug
ID PLASMODIUM-FALCIPARUM; ANTIMALARIAL-DRUGS; INVITRO; GROWTH
AB The use of mefloquine (MQ) for antimalarial treatment and prophylaxis has diminished largely in response to concerns about its neurologic side effects. An analog campaign designed to maintain the efficacy of MQ while minimizing blood-brain barrier (BBB) penetration has resulted in the synthesis of a prodrug with comparable-to-superior in vivo efficacy versus mefloquine in a P. berghei mouse model while exhibiting a sixfold reduction in CNS drug levels. The prodrug, WR319670, performed poorly compared to MQ in in vitro efficacy assays, but had promising in vitro permeability in an MDCK-MDR1 cell line BBB permeability screen. Its metabolite, WR308245, exhibited high predicted BBB penetration with excellent in vitro efficacy. Both WR319670 and WR308245 cured 5/5 animals in separate in vivo efficacy studies. The in vivo efficacy of WR319670 was thought to be due to the formation of a more active metabolite, specifically WR308245. This was supported by pharmacokinetics studies in non-infected mice, which showed that both IV and oral administration of WR319670 produced essentially identical levels of WR319670 and WR308245 in both plasma and brain samples at all time points. In these studies, the levels of WR308245 in the brain were 1/4 and 1/6 that of MQ in similar IV and oral studies, respectively. These data show that the use of WR319670 as an antimalarial prodrug was able to maintain efficacy in in vivo efficacy screens, while significantly lowering overall penetration of drug and metabolites across the BBB.
C1 [Sousa, Jason C.; Milner, Erin; Carroll, Dustin; McCalmont, William; Gardner, Sean; Moon, Jay; Johnson, Jacob D.; Lee, Patricia; Auschwitz, Jennifer; Roncal, Norma; Caridha, Diana; Zeng, Qiang; Reyes, Sean; Smith, Bryan; Li, Qigui; Kozar, Michael P.; Melendez, Victor; Dow, Geoffrey] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
[Tungteung, Anchalee] US Army Med Component, Armed Forces Res Inst Med Sci, Bangkok, Thailand.
[Dow, Geoffrey] US Army Med Mat Dev Act, Frederick, MD 21702 USA.
RP Sousa, JC (reprint author), Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
EM Jason.sousa@amedd.army.mil; geoffrey.dow@us.army.mil
NR 14
TC 1
Z9 1
U1 2
U2 11
PU SPRINGER FRANCE
PI PARIS
PA 22 RUE DE PALESTRO, PARIS, 75002, FRANCE
SN 0378-7966
EI 2107-0180
J9 EUR J DRUG METAB PH
JI Eur. J. Drug Metabol. Pharmacokinet.
PD DEC
PY 2014
VL 39
IS 4
BP 231
EP 236
DI 10.1007/s13318-013-0162-9
PG 6
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA AT2DJ
UT WOS:000344741300001
PM 24705994
ER
PT J
AU O'Connell, RJ
Kim, JH
Excler, JL
AF O'Connell, Robert J.
Kim, Jerome H.
Excler, Jean-Louis
TI The HIV-1 gp120 V1V2 loop: structure, function and importance for
vaccine development
SO EXPERT REVIEW OF VACCINES
LA English
DT Review
DE efficacy; gp120; HIV vaccine; neutralizing antibodies; nonneutralizing
antibodies; RV144; V1V2 loop
ID IMMUNODEFICIENCY-VIRUS TYPE-1; RECOMBINANT GLYCOPROTEIN-120 VACCINE;
BROADLY NEUTRALIZING ANTIBODIES; T-CELL RESPONSES; EFFICACY TRIAL;
ENVELOPE GLYCOPROTEIN; HIV-1-INFECTED INDIVIDUALS;
MONOCLONAL-ANTIBODIES; RHESUS-MONKEYS; GLYCOSYLATION SITES
AB Although the second variable loop (V2) of the HIV-1 gp120 envelope glycoprotein shows substantial sequence diversity between strains, its functional importance imposes critical conservation of structure, and within particular microdomains, of sequence. V2 influences HIV-1 viral entry by contributing to trimer stabilization and co-receptor binding. It is one of 4 key domains targeted by the broadly neutralizing antibodies that arise during HIV-1 infection. HIV-1 uses V1V2 sequence variation and glycosylation to escape neutralizing antibody. In the Thai Phase III HIV-1 vaccine trial, RV144, vaccine-induced IgG against V1V2 inversely correlated with the risk of HIV-1 acquisition, and HIV-1 strains infecting RV144 vaccine recipients differed from those infecting placebo recipients in the V2 domain. Similarly, non-human primate challenge studies demonstrated an inverse correlation between vaccine-induced anti-V2 responses and simian immunodeficiency virus acquisition. We hypothesize that increased magnitude, frequency and duration of vaccine-induced anti-V2 antibody responses should improve efficacy afforded by pox-protein prime-boost HIV vaccine strategies.
C1 [O'Connell, Robert J.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
[Kim, Jerome H.; Excler, Jean-Louis] US Mil HIV Res Program MHRP, Bethesda, MD 20817 USA.
[Excler, Jean-Louis] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD 20817 USA.
RP O'Connell, RJ (reprint author), Armed Forces Res Inst Med Sci, 315-6 Rajvithi Rd, Bangkok 10400, Thailand.
EM robert.oconnell@afrims.org
FU US Army Medical Research and Materiel Command (USAMRMC)
[DAMD17-98-2-7007]; Henry M. Jackson Foundation for the Advancement of
Military Medicine
FX The authors received funding from the US Army Medical Research and
Materiel Command (USAMRMC), and its Cooperative Agreement
(DAMD17-98-2-7007) with the Henry M. Jackson Foundation for the
Advancement of Military Medicine. The views expressed in this manuscript
are those of the authors and do not reflect the official policy or
position of the Department of the Army, Department of Defense or the US
Government. The authors have no other relevant affiliations or financial
involvement with any organization or entity with a financial interest in
or financial conflict with the subject matter or materials discussed in
the manuscript apart from those disclosed.
NR 108
TC 3
Z9 3
U1 3
U2 23
PU EXPERT REVIEWS
PI LONDON
PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB,
ENGLAND
SN 1476-0584
EI 1744-8395
J9 EXPERT REV VACCINES
JI Expert Rev. Vaccines
PD DEC
PY 2014
VL 13
IS 12
BP 1489
EP 1500
DI 10.1586/14760584.2014.951335
PG 12
WC Immunology
SC Immunology
GA AT4TL
UT WOS:000344935000008
PM 25163695
ER
PT J
AU Reid, MW
Miller, KJ
Lange, RT
Cooper, DB
Tate, DF
Bailie, J
Brickell, TA
French, LM
Asmussen, S
Kennedy, JE
AF Reid, Matthew W.
Miller, Kelly J.
Lange, Rael T.
Cooper, Douglas B.
Tate, David F.
Bailie, Jason
Brickell, Tracey A.
French, Louis M.
Asmussen, Sarah
Kennedy, Jan E.
TI A Multisite Study of the Relationships between Blast Exposures and
Symptom Reporting in a Post-Deployment Active Duty Military Population
with Mild Traumatic Brain Injury
SO JOURNAL OF NEUROTRAUMA
LA English
DT Article
DE post-concussion; blast; post-traumatic stress; neurobehavioral symptom
inventory; mild traumatic brain injury
ID POSTTRAUMATIC-STRESS-DISORDER; OIF/OEF SERVICE MEMBERS; POSTCONCUSSIVE
SYMPTOMS; IRAQI FREEDOM; HEALTH; VETERANS; TBI; ASSOCIATIONS; PTSD
AB Explosive devices have been the most frequent cause of traumatic brain injury (TBI) among deployed contemporary U.S. service members. The purpose of this study was to examine the influence of previous cumulative blast exposures (that did or did not result in TBI) on later post-concussion and post-traumatic symptom reporting after sustaining a mild TBI (MTBI). Participants were 573 service members who sustained MTBI divided into four groups by number of blast exposures (1, 2, 3, and 4-10) and a nonblast control group. Post-concussion symptoms were measured using the Neurobehavioral Symptom Inventory (NSI) and post-traumatic stress disorder (PTSD) symptoms using the Post-traumatic Checklist-Civilian version (PCL-C). Results show groups significantly differed on total NSI scores (p<0.001), where symptom endorsement increased as number of reported blast exposures increased. Total NSI scores were significantly higher for the 3- and 4-10 blast groups compared with the 1- and 2-blast groups with effect sizes ranging from small to moderate (d=0.31 to 0.63). After controlling for PTSD symptoms using the PCL-C total score, NSI total score differences remained between the 4-10-blast group and the 1- and 2-blast groups, but were less pronounced (d=0.35 and d=0.24, respectively). Analyses of NSI subscale scores using PCL-C scores as a covariate revealed significant between-blast group differences on cognitive, sensory, and somatic, but not affective symptoms. Regression analyses revealed that cumulative blast exposures accounted for a small but significant amount of the variance in total NSI scores (4.8%; p=0.009) and total PCL-C scores (2.3%; p<0.001). Among service members exposed to blast, post-concussion symptom reporting increased as a function of cumulative blast exposures. Future research will need to determine the relationship between cumulative blast exposures, symptom reporting, and neuropathological changes.
C1 [Reid, Matthew W.; Miller, Kelly J.; Lange, Rael T.; Cooper, Douglas B.; Tate, David F.; Bailie, Jason; Brickell, Tracey A.; French, Louis M.; Asmussen, Sarah; Kennedy, Jan E.] Def & Vet Brain Injury Ctr, Silver Spring, MD USA.
[Reid, Matthew W.; Cooper, Douglas B.; Tate, David F.; Kennedy, Jan E.] San Antonio Mil Med Ctr, San Antonio, TX USA.
[Miller, Kelly J.; Lange, Rael T.; Brickell, Tracey A.; French, Louis M.] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA.
[Brickell, Tracey A.; French, Louis M.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Lange, Rael T.; Brickell, Tracey A.; French, Louis M.] Ctr Neurosci & Regenerat Med, Bethesda, MD USA.
[Lange, Rael T.] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada.
[Bailie, Jason; Asmussen, Sarah] Naval Med Ctr San Diego, San Diego, CA USA.
[Asmussen, Sarah] Marine Corps Base Camp Pendleton, Camp Pendleton, CA USA.
RP Reid, MW (reprint author), Brooke Army Med Ctr, MCHE MDU DVBIC, 3551 Roger Brooke Dr, Jbsa Ft Sam Houston, TX 78234 USA.
EM matthew.w.reid2.ctr@mail.mil
RI Tate, David/I-3963-2013
FU NINDS NIH HHS [L30 NS063444]
NR 26
TC 14
Z9 14
U1 1
U2 3
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD DEC 1
PY 2014
VL 31
IS 23
BP 1899
EP 1906
DI 10.1089/neu.2014.3455
PG 8
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA AT6US
UT WOS:000345075500001
PM 25036531
ER
PT J
AU Kogot, JM
Pennington, JM
Sarkes, DA
Kingery, DA
Pellegrino, PM
Stratis-Cullum, DN
AF Kogot, Joshua M.
Pennington, Joseph M.
Sarkes, Deborah A.
Kingery, David A.
Pellegrino, Paul M.
Stratis-Cullum, Dimitra N.
TI Screening and characterization of anti-SEB peptides using a bacterial
display library and microfluidic magnetic sorting
SO JOURNAL OF MOLECULAR RECOGNITION
LA English
DT Article
DE SEB; peptide; bacterial display; microfluidic; peptide ELISA; peptide
display; biothreat
ID STAPHYLOCOCCAL-ENTEROTOXIN-B; FLOW-CYTOMETRY; AFFINITY; PROTEINS;
LIGANDS
AB Bacterial peptide display libraries enable the rapid and efficient selection of peptides that have high affinity and selectivity toward their targets. Using a 15-mer random library on the outer surface of Escherichia coli (E.coli), high-affinity peptides were selected against a staphylococcal enterotoxin B (SEB) protein after four rounds of biopanning. On-cell screening analysis of affinity and specificity were measured by flow cytometry and directly compared to the synthetic peptide, off-cell, using peptide-ELISA. DNA sequencing of the positive clones after four rounds of microfluidic magnetic sorting (MMS) revealed a common consensus sequence of (S/T)CH(Y/F)W for the SEB-binding peptides R338, R418, and R445. The consensus sequence in these bacterial display peptides has similar amino acid characteristics with SEB peptide sequences isolated from phage display. The K-d measured by peptide-ELISA off-cell was 2.4nM for R418 and 3.0nM for R445. The bacterial peptide display methodology using the semiautomated MMS resulted in the discovery of selective peptides with affinity for a food safety and defense threat. Published 2014. This article is a U.S. Government work and is in the public domain in the USA. Journal of Molecular Recognition published by John Wiley & Sons, Ltd.
C1 [Kogot, Joshua M.; Pennington, Joseph M.; Sarkes, Deborah A.; Kingery, David A.; Pellegrino, Paul M.; Stratis-Cullum, Dimitra N.] US Army Res Lab, Adelphi, MD 20783 USA.
RP Stratis-Cullum, DN (reprint author), US Army Res Lab, Adelphi, MD 20783 USA.
EM dimitra.n.stratis-cullum.civ@mail.mil
NR 29
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Z9 4
U1 5
U2 46
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0952-3499
EI 1099-1352
J9 J MOL RECOGNIT
JI J. Mol. Recognit.
PD DEC
PY 2014
VL 27
IS 12
BP 739
EP 745
DI 10.1002/jmr.2400
PG 7
WC Biochemistry & Molecular Biology; Biophysics
SC Biochemistry & Molecular Biology; Biophysics
GA AS0WU
UT WOS:000343997400007
PM 25319622
ER
PT J
AU Jenks, C
AF Jenks, C.
TI Moral touchstone, not general deterrence: The role of international
criminal justice in fostering compliance with international humanitarian
law
SO INTERNATIONAL REVIEW OF THE RED CROSS
LA English
DT Article
DE deterrence; compliance; international criminal justice; international
humanitarian law; prevention
C1 [Jenks, C.] SMU Dedman Sch Law, Law, Dallas, TX 75205 USA.
[Jenks, C.] SMU Dedman Sch Law, Criminal Justice Clin, Dallas, TX USA.
[Jenks, C.] SMU, Fac Law, Dallas, TX USA.
[Jenks, C.] US Army, Washington, DC USA.
[Jenks, C.] Armys Int Law Branch, Pentagon, VA USA.
RP Jenks, C (reprint author), SMU Dedman Sch Law, Law, Dallas, TX 75205 USA.
NR 52
TC 0
Z9 0
U1 0
U2 0
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 1816-3831
EI 1607-5889
J9 INT REV RED CROSS
JI Int. Rev. Red Cross
PD DEC
PY 2014
VL 96
IS 895
BP 776
EP 794
PG 19
WC Law
SC Government & Law
GA V41PB
UT WOS:000209557000007
ER
PT J
AU Davis, MT
Mulvaney-Day, N
Larson, MJ
Hoover, R
Mauch, D
AF Davis, Margot T.
Mulvaney-Day, Norah
Larson, Mary Jo
Hoover, Ronald
Mauch, Danna
TI Complementary and Alternative Medicine Among Veterans and Military
Personnel A Synthesis of Population Surveys
SO MEDICAL CARE
LA English
DT Article
DE military veteran; complementary alternative medicine; population survey;
psychological health conditions; PTSD; survey analysis
AB Background: Recent reports reinforce the widespread interest in complementary and alternative medicine (CAM), not only among military personnel with combat-related disorders, but also among providers who are pressed to respond to patient demand for these therapies. However, an understanding of utilization of CAM therapies in this population is lacking.
Objective: The goals of this study are to synthesize the content of self-report population surveys with information on use of CAM in military and veteran populations, assess gaps in knowledge, and suggest ways to address current limitations.
Research Design: The research team conducted a literature review of population surveys to identify CAM definitions, whether military status was queried, the medical and psychological conditions queried, and each specific CAM question. Utilization estimates specific to military/veterans were summarized and limitations to knowledge was classified.
Results: Seven surveys of CAM utilization were conducted with military/veteran groups. In addition, 7 household surveys queried military status, although there was no military/veteran subgroup analysis. Definition of CAM varied widely limiting cross-survey analysis. Among active duty and Reserve military, CAM use ranged between 37% and 46%. Survey estimates do not specify CAM use that is associated with a medical or behavioral health condition.
Conclusions: Comparisons between surveys are hampered due to variation in methodologies. Too little is known about reasons for using CAM and conditions for which it is used. Additional information could be drawn from current surveys with additional subgroup analysis, and future surveys of CAM should include military status variable.
C1 [Davis, Margot T.; Larson, Mary Jo] Brandeis Univ, Heller Sch Social Policy & Management, Inst Behav Hlth, 415 South St, Waltham, MA 02454 USA.
[Mulvaney-Day, Norah; Mauch, Danna] Abt Associates Inc, Cambridge, MA USA.
[Hoover, Ronald] US Army Med Res & Mat Command, Ft Detrick, MD USA.
RP Davis, MT (reprint author), Brandeis Univ, Heller Sch Social Policy & Management, Inst Behav Hlth, 415 South St, Waltham, MA 02454 USA.
EM margotd@brandeis.edu
FU Institute of Behavioral Health, Heller School, Brandeis University
FX The authors would like to acknowledge the support of Institute of
Behavioral Health, Heller School, Brandeis University and additional
research help from Lauren Hajjar.
NR 43
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U1 4
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7079
EI 1537-1948
J9 MED CARE
JI Med. Care
PD DEC
PY 2014
VL 52
IS 12
SU 5
BP S83
EP S90
PG 8
WC Health Care Sciences & Services; Health Policy & Services; Public,
Environmental & Occupational Health
SC Health Care Sciences & Services; Public, Environmental & Occupational
Health
GA V45TM
UT WOS:000209838900014
PM 25397828
ER
PT J
AU Gerdes, J
Holness, A
Perez-Rosado, A
Roberts, L
Greisinger, A
Barnett, E
Kempny, J
Lingam, D
Yeh, CH
Bruck, HA
Gupta, SK
AF Gerdes, John
Holness, Alex
Perez-Rosado, Ariel
Roberts, Luke
Greisinger, Adrian
Barnett, Eli
Kempny, Johannes
Lingam, Deepak
Yeh, Chen-Haur
Bruck, Hugh A.
Gupta, Satyandra K.
TI Robo Raven: A Flapping-Wing Air Vehicle with Highly Compliant and
Independently Controlled Wings
SO SOFT ROBOTICS
LA English
DT Article
ID MANEUVERING FLIGHT; AVIAN TAIL; AERODYNAMICS; MECHANISMS; EFFICIENCY;
PIGEONS; DESIGN; BIRDS
AB Many current bird-inspired flapping-wing air vehicles (FWAVs) achieve their flight characteristics through deformations associated with compliant wings during the flapping cycle. Most FWAVs use a single actuator to flap both wings. This couples and synchronizes motions of the wings, which only provides variable rate flapping at constant amplitude to control wing deformations. Independent wing control has the potential to provide a greater flight envelope through the ability to program wing motions to achieve a desired wing shape and associated aerodynamic forces. This approach requires the use of at least two actuators with position and velocity control that can be programmed to drive the wings independently. Integration of two actuators in a flying platform significantly increases the weight and hence makes it challenging to achieve flight. Based on our previous designs with synchronized wing flapping, we developed a new FWAV platform using programmable digital servo motors and a compatible highly compliant wing design that enables shape control of the wings during the flapping cycle. The wings and flapping characteristics can generate the highest possible lift near the maximum power operating point for the servos. The servos were integrated into a wing drive subsystem consisting of 3D printed and laser-etched/cut structural components to reduce part count and weight. A servo-driven tail was also used to augment the steering control and lift of the FWAV. The platform reported in this article, known as Robo Raven, was the first demonstration of a bird-inspired platform doing outdoor aerobatics using independently actuated and controlled wings. This platform successfully performed dives, flips, and buttonhook turns, demonstrating the capability of bioinspired aerobatic maneuvers afforded by the new design.
C1 [Gerdes, John] US Army Res Lab, Aberdeen Proving Ground, MD USA.
[Holness, Alex; Perez-Rosado, Ariel; Roberts, Luke; Greisinger, Adrian; Barnett, Eli; Kempny, Johannes; Lingam, Deepak; Yeh, Chen-Haur; Bruck, Hugh A.; Gupta, Satyandra K.] Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA.
RP Gupta, SK (reprint author), Univ Maryland, Dept Mech Engn, 2181 Martin Hall, College Pk, MD 20742 USA.
EM skgupta@umd.edu
FU U.S. Army Research Laboratory Vehicle Technologies Directorate; Science,
Mathematics, & Research for Transformation Scholarship; AFOSR
[FA9550-12-1-0158]
FX This work was sponsored in part by U.S. Army Research Laboratory Vehicle
Technologies Directorate and the Science, Mathematics, & Research for
Transformation Scholarship, administered by the American Society for
Engineering Education and Naval Postgraduate School and AFOSR grant
FA9550-12-1-0158. The support of Dr. Byung-Lip "Les'' Lee program
manager, AFOSR is also greatly appreciated.
NR 58
TC 19
Z9 19
U1 4
U2 16
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2169-5172
EI 2169-5180
J9 SOFT ROBOT
JI Soft Robot.
PD DEC
PY 2014
VL 1
IS 4
BP 275
EP 288
DI 10.1089/soro.2014.0019
PG 14
WC Robotics
SC Robotics
GA CV8WI
UT WOS:000364568400008
ER
PT J
AU Gilbert, JA
Ball, M
Blainey, P
Blaser, MJ
Bohannan, BJ
Bateman, A
Bunge, J
Dominguez-Bello, MG
Epstein, S
Fierer, N
Gevers, D
Grikscheit, T
Hamdan, LJ
Harvey, J
Huttenhower, C
Kirkup, B
Kong, HH
Lauber, C
Lemon, KP
Lynch, SV
Martin, L
Mello, C
Palma, J
Parker, R
Petrosino, J
Segre, JA
Vosshall, L
Yi, R
Knight, R
AF Gilbert, Jack A.
Ball, Madeleine
Blainey, Paul
Blaser, Martin J.
Bohannan, Brendan Jm
Bateman, Ashley
Bunge, John
Dominguez-Bello, Maria Gloria
Epstein, Slava
Fierer, Noah
Gevers, Dirk
Grikscheit, Tracy
Hamdan, Leila J.
Harvey, James
Huttenhower, Curtis
Kirkup, Benjamin
Kong, Heidi H.
Lauber, Christian
Lemon, Katherine P.
Lynch, Susan V.
Martin, Lance
Mello, Charlene
Palma, Joseph
Parker, Roy
Petrosino, Joseph
Segre, Julia A.
Vosshall, Leslie
Yi, Rui
Knight, Rob
TI Meeting report for the 1st skin microbiota workshop, boulder, CO October
15-16 2012
SO STANDARDS IN GENOMIC SCIENCES
LA English
DT Article
DE Skin microbiome; Army; Bioinformatics
AB This report details the outcome of the 1st Skin Microbiota Workshop, Boulder, CO, held on October 15th-16th 2012. The workshop was arranged to bring Department of Defense personnel together with experts in microbial ecology, human skin physiology and anatomy, and computational techniques for interrogating the microbiome to define research frontiers at the intersection of these important areas. The workshop outlined a series of questions and created several working groups to address those questions, specifically to promote interdisciplinary activity and potential future collaboration. The US Army provided generous grant support and the meeting was organized and hosted by the University of Colorado at Boulder. A primary forward vision of the meeting was the importance of understanding skin microbial communities to improve the health and stealth of US Army warfighters.
C1 [Gilbert, Jack A.] Argonne Natl Lab, 9700 S Cass Ave, Argonne, IL 60439 USA.
[Gilbert, Jack A.] Univ Chicago, Dept Ecol & Evolut, Chicago, IL 60637 USA.
[Ball, Madeleine] Harvard Med Sch, Dept Genet, Boston, MA 02115 USA.
Broad Inst & MIT Dept Biol Engn, Cambridge, MA USA.
[Blaser, Martin J.] NYU Langone Med Ctr, Dept Med, New York, NY USA.
New York Harbor VA Med Ctr, New York, NY USA.
[Bohannan, Brendan Jm; Bateman, Ashley] Univ Oregon, Inst Ecol & Evolut, Eugene, OR 97403 USA.
[Bunge, John] Cornell Univ, Dept Stat Sci, Ithaca, NY USA.
[Dominguez-Bello, Maria Gloria] NYU, Dept Med, New York, NY 10016 USA.
[Dominguez-Bello, Maria Gloria] Univ Puerto Rico, Dept Biol, Mayaguez, PR USA.
[Epstein, Slava] Northeastern Univ, Dept Biol, Boston, MA 02115 USA.
[Fierer, Noah] Univ Colorado, Dept Ecol & Evolutionary Biol, Boulder, CO 80309 USA.
[Fierer, Noah; Lauber, Christian] Univ Colorado, CIRES, Boulder, CO 80309 USA.
[Gevers, Dirk] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.
[Grikscheit, Tracy] Childrens Hosp Los Angeles, Saban Res Inst, USC, Div Pediat Surg,Keck Sch Med, Los Angeles, CA 90027 USA.
[Hamdan, Leila J.] George Mason Univ, Manassas, VA 20110 USA.
[Harvey, James] US Army Res Off, Res Triangle Pk, NC USA.
[Huttenhower, Curtis] Harvard Sch Publ Hlth, Dept Biostat, Boston, MA USA.
[Kirkup, Benjamin] Walter Reed Army Inst Res, Dept Wound Infect, Silver Spring, MD USA.
[Kirkup, Benjamin] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA.
[Kong, Heidi H.] NCI, NIH, Dermatol Branch, Ctr Canc Res, Bethesda, MD 20892 USA.
[Lemon, Katherine P.] Forsyth Inst, Dept Microbiol, Cambridge, MA USA.
[Lemon, Katherine P.] Boston Childrens Hosp, Div Infect Dis, Boston, MA USA.
[Lynch, Susan V.] Univ Calif San Francisco, Dept Med, Div Gastroenterol, San Francisco, CA USA.
[Martin, Lance] Stanford Univ, Sch Med, Dept Bioengn, Program Epithelial Biol, Stanford, CA 94305 USA.
[Martin, Lance] Stanford Univ, Stanford, CA 94305 USA.
[Mello, Charlene; Palma, Joseph] US Natick Soldier Ctr, Natick, MA USA.
[Parker, Roy; Knight, Rob] Howard Hughes Med Inst, Boulder, CO USA.
[Parker, Roy; Knight, Rob] Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA.
[Parker, Roy; Knight, Rob] Univ Colorado, BioFrontiers Inst, Boulder, CO 80309 USA.
[Petrosino, Joseph] Baylor Coll Med, Dept Mol Virol & Microbiol, Alkek Ctr Metagen & Microbiome Res, Houston, TX 77030 USA.
[Segre, Julia A.] NHGRI, NIH, Bethesda, MD 20892 USA.
[Vosshall, Leslie] Rockefeller Univ, Howard Hughes Med Inst, New York, NY 10021 USA.
[Yi, Rui] Univ Colorado, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USA.
RP Gilbert, JA (reprint author), Argonne Natl Lab, 9700 S Cass Ave, Argonne, IL 60439 USA.
EM gilbertjack@gmail.com
OI Blainey, Paul/0000-0002-4889-8783; Kirkup, Benjamin/0000-0002-8722-6218;
Kong, Heidi/0000-0003-4424-064X
FU U.S. Army Research Laboratory; U.S. Army Research Office
[W911NF-12-1-0513]
FX This workshop was supported in part by the U.S. Army Research Laboratory
and the U.S. Army Research Office under grant number W911NF-12-1-0513.
We thank Wally Buchholtz, who is the program manager for this program,
and Jerry Kennedy and Ulla Westermann for superb assistance on the
logistics.
NR 26
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U1 1
U2 1
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1944-3277
J9 STAND GENOMIC SCI
JI Stand. Genomic Sci.
PD DEC
PY 2014
VL 9
IS 1
AR 13
DI 10.1186/1944-3277-9-13
PG 7
WC Genetics & Heredity; Microbiology
SC Genetics & Heredity; Microbiology
GA V45LA
UT WOS:000209816900013
ER
PT J
AU Westwood, J
Burnett, M
Spratt, D
Ball, M
Wilson, DJ
Wellsteed, S
Cleary, D
Green, A
Hutley, E
Cichowska, A
Hopkins, S
Wilcox, M
Kessel, A
Zoubiane, G
Bethke, L
Crook, DW
Walker, J
Sutton, M
Marsh, P
Moore, G
Wilson, P
Holmes, A
Hoffman, P
Smith, C
Oppenheim, B
Parkhill, J
Woodford, N
Robotham, J
Kidgell, C
Anyim, M
Gilkes, G
Field, D
Quick, J
Pickering, T
Kirkup, BC
Gilbert, J
AF Westwood, Jack
Burnett, Matthew
Spratt, David
Ball, Michael
Wilson, Daniel J.
Wellsteed, Sally
Cleary, David
Green, Andy
Hutley, Emma
Cichowska, Anna
Hopkins, Susan
Wilcox, Mark
Kessel, Anthony
Zoubiane, Ghada
Bethke, Lara
Crook, Derrick W.
Walker, Jimmy
Sutton, Mark
Marsh, Philip
Moore, Ginny
Wilson, Peter
Holmes, Alison
Hoffman, Peter
Smith, Chris
Oppenheim, Beryl
Parkhill, Julian
Woodford, Neil
Robotham, Julie
Kidgell, Claire
Anyim, Martin
Gilkes, Gabriella
Field, Dawn
Quick, Josh
Pickering, Tony
Kirkup, Benjamin C.
Gilbert, Jack
TI The hospital microbiome project: meeting report for the UK science and
innovation network UK-USA workshop 'beating the superbugs: hospital
microbiome studies for tackling antimicrobial resistance', October 14th
2013
SO STANDARDS IN GENOMIC SCIENCES
LA English
DT Article
DE Antibiotic resistance; Nosocomial infections; Hospital microbiome;
Superbugs
AB The UK Science and Innovation Network UK-USA workshop 'Beating the Superbugs: Hospital Microbiome Studies for tackling Antimicrobial Resistance' was held on October 14th 2013 at the UK Department of Health, London. The workshop was designed to promote US-UK collaboration on hospital microbiome studies to add a new facet to our collective understanding of antimicrobial resistance. The assembled researchers debated the importance of the hospital microbial community in transmission of disease and as a reservoir for antimicrobial resistance genes, and discussed methodologies, hypotheses, and priorities. A number of complementary approaches were explored, although the importance of the built environment microbiome in disease transmission was not universally accepted. Current whole genome epidemiological methods are being pioneered in the UK and the benefits of moving to community analysis are not necessarily obvious to the pioneers; however, rapid progress in other areas of microbiology suggest to some researchers that hospital microbiome studies will be exceptionally fruitful even in the short term. Collaborative studies will recombine different strengths to tackle the international problems of antimicrobial resistance and hospital and healthcare associated infections.
C1 [Westwood, Jack] British Consulate Gen, Chicago, IL 60611 USA.
[Burnett, Matthew; Smith, Chris] Univ Cambridge, Dept Pathol, Cambridge, England.
[Spratt, David] UCL Eastman Dent Inst, Dept Microbial Dis, London, England.
[Ball, Michael] Biotechnol & Biol Sci Res Council, Swindon, Wilts, England.
[Wilson, Daniel J.] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Med, Oxford, England.
[Wellsteed, Sally] Richmond House, Dept Hlth, London, England.
[Cleary, David] Def Sci & Technol Lab, Porton Down, Wilts, England.
[Green, Andy; Hutley, Emma] Royal Ctr Def Med, Birmingham, W Midlands, England.
[Cichowska, Anna; Hopkins, Susan; Kessel, Anthony] Publ Hlth England, London, England.
[Wilcox, Mark] Univ Leeds, Leeds, W Yorkshire, England.
[Wilcox, Mark] Leeds Teaching Hosp, Leeds, W Yorkshire, England.
[Zoubiane, Ghada] MRC, London, England.
[Bethke, Lara] Wellcome Trust Res Labs, London, England.
[Crook, Derrick W.] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Med, Oxford OX3 9DU, England.
[Walker, Jimmy; Moore, Ginny] Publ Hlth England, Biosafety Unit, Salisbury, Wilts, England.
[Sutton, Mark; Marsh, Philip] HPA Microbiol Serv, Salisbury, Wilts, England.
[Wilson, Peter] UCLH NHS Fdn Trust, Clin Microbiol & Virol, London, England.
[Holmes, Alison] Imperial Coll, London, England.
[Hoffman, Peter; Woodford, Neil] Publ Hlth England, Antimicrobial Resistance & Healthcare Associated, London, England.
[Smith, Chris] Addenbrookes Hosp, Clin Microbiol & Publ Hlth Lab, Cambridge, England.
[Oppenheim, Beryl] Queen Elizabeth Hosp, Birmingham, W Midlands, England.
[Parkhill, Julian] Wellcome Trust Genome Campus, Wellcome Trust Sanger Inst, Cambridge, England.
[Robotham, Julie] Publ Hlth England, Modeling & Econ Unit, Stat Modeling & Econ Dept, London, England.
[Kidgell, Claire] Univ Southampton, Natl Inst Hlth Res, Evaluat Trials & Studies Coordinating Ctr NETSCC, Southampton, Hants, England.
[Anyim, Martin] NIHR Invent Innovat Programme, London, England.
[Gilkes, Gabriella] Human Micro Biome Project, Eden Project, St Austell PL24 2SG, Cornwall, England.
[Field, Dawn] NERC Ctr Ecol & Hydrol, Oxford, England.
[Quick, Josh] Univ Birmingham, Inst Microbiol & Infect, Birmingham, W Midlands, England.
[Pickering, Tony] Univ South Manchester, North West Lung Res Ctr, Wythenshawe Hosp, Manchester, Lancs, England.
[Kirkup, Benjamin C.] Walter Reed Army Inst Res, Dept Wound Infect, Bethesda, MD USA.
[Gilbert, Jack] Univ Chicago, Dept Ecol & Evolut, 940 E 57Th St, Chicago, IL 60637 USA.
[Gilbert, Jack] Argonne Natl Lab, Inst Genom & Syst Biol, Argonne, IL 60439 USA.
RP Gilbert, J (reprint author), Univ Chicago, Dept Ecol & Evolut, 940 E 57Th St, Chicago, IL 60637 USA.
EM gilbertjack@uchicago.edu
OI Wilson, Daniel/0000-0002-0940-3311; Bethke, Lara/0000-0002-1316-4704;
Hopkins, Susan/0000-0001-5179-5702
FU UK Science and Innovation Network; British Consulate-General Chicago;
Foreign and Commonwealth Office; APSF; U.S. Dept. of Energy
[DE-AC02-06CH11357]
FX We acknowledge the UK Science and Innovation Network, British
Consulate-General Chicago and Foreign and Commonwealth Office, as well
as APSF for funding this workshop. This work was supported in part by
the U.S. Dept. of Energy under Contract DE-AC02-06CH11357. The opinions
and assertions contained herein are the private views of the authors and
are not to be construed as official or as reflecting true views of the
Department of Army or the Department of Defense.
NR 31
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U1 0
U2 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1944-3277
J9 STAND GENOMIC SCI
JI Stand. Genomic Sci.
PD DEC
PY 2014
VL 9
IS 1
AR 12
DI 10.1186/1944-3277-9-12
PG 12
WC Genetics & Heredity; Microbiology
SC Genetics & Heredity; Microbiology
GA V45LA
UT WOS:000209816900012
ER
PT J
AU Lichvar, RW
AF Lichvar, Robert W.
TI GENOMIC SIZE AND PLOIDY LEVEL PATTERNS OF INTERMOUNTAIN WEST LEPIDIUM
DETERMINED USING FLOW CYTOMETRY
SO WESTERN NORTH AMERICAN NATURALIST
LA English
DT Article
ID NUCLEAR-DNA AMOUNTS; GENUS DRABA; BRASSICACEAE; CRUCIFERAE; EVOLUTION;
PLANTS; ANGIOSPERMS; POLYPLOIDY; COMPLEX
AB The taxonomic status of members of the genus Lepidium in the Intermountain West has been in flux for years. Species concepts and classification of these endemic species from the western United States center on the highly variable L. montanum complex. Until recently, classification treatments that use morphological features in this group have been adequate, but as new species are discovered and more locations reported, the limited number of morphological features available for classification and defining species concepts has led to more uncertainty about taxonomic rankings. As part of a molecular and morphological-based treatment of the group, flow cytometry was used to evaluate 58 collections of Lepidium from the Intermountain West. The ploidy level for 14 species and 11 varieties of Lepidium was surveyed to assess whether ploidy levels affected the interpretation of taxonomic rankings. Of the Lepidium taxa surveyed, 90% were tetraploid, and several were diploid and hexaploid. Tetraploid occurrences crossed all major species and varieties. No geographic distribution or habitat patterns were associated with ploidy level.
C1 [Lichvar, Robert W.] US Army, Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA.
RP Lichvar, RW (reprint author), US Army, Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA.
EM robert.w.lichvar@usace.army.mil
FU U.S. Army Corps of Engineers Engineering and Research Development
Center/Cold Regions Research and Engineering Laboratory (ERDC/CRREL)
Hanover, New Hampshire
FX The quality and content of information reported here would not have been
possible without the guidance, comments, and reviews provided by Diana
Wolf and Gary Laursen of the University of Alaska and Ihsan Al-Shehbaz
of the Missouri Botanical Garden. Funding for this effort was made
possible by the U.S. Army Corps of Engineers Engineering and Research
Development Center/Cold Regions Research and Engineering Laboratory
(ERDC/CRREL), Hanover, New Hampshire.
NR 44
TC 0
Z9 0
U1 1
U2 2
PU BRIGHAM YOUNG UNIV
PI PROVO
PA 290 LIFE SCIENCE MUSEUM, PROVO, UT 84602 USA
SN 1527-0904
EI 1944-8341
J9 WEST N AM NATURALIST
JI West. North Am. Naturalist
PD DEC
PY 2014
VL 74
IS 4
BP 369
EP 377
DI 10.3398/064.074.0402
PG 9
WC Biodiversity Conservation; Ecology
SC Biodiversity & Conservation; Environmental Sciences & Ecology
GA DE8NN
UT WOS:000370892900001
ER
PT J
AU Migliaccio, CP
AF Migliaccio, Christopher P.
TI Resonance-induced condensate shedding for high-efficiency heat transfer
SO INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
LA English
DT Article
DE Dropwise condensation; Resonance; Condensate shedding; Vibrating
condenser
ID DROPWISE CONDENSATION; SUPERHYDROPHOBIC SURFACES; SESSILE DROPS;
VIBRATION; MOTION
AB Condensers are heat rejection devices vital to industrial-scale systems including those found in the process and power industries. In a dropwise condensation system, the heat transferred to the condensing surface is related to the size distribution of attached drops. This study subjects a vertically-oriented condensing surface to mechanical vibrations ranging from 100 to 400 Hz, exciting the resonance modes of appropriately sized condensate drops. Resonating drops mobilize and shed from the surface at smaller size and with greater frequency than compared to a case without vibration, reducing the population of large, thermally inefficient drops on the surface. Excitation frequencies of 100 and 200 Hz yielded net improvement in estimated heat transfer rate in excess of 70% over the stationary case, suggesting that substantial reductions in fuel usage and footprint may be realized by applying this concept in condenser design. Published by Elsevier Ltd.
C1 US Army Res Lab, Adelphi, MD 20783 USA.
RP Migliaccio, CP (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM christopher.p.migliaccio.civ@mail.mil
NR 41
TC 0
Z9 0
U1 6
U2 17
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0017-9310
EI 1879-2189
J9 INT J HEAT MASS TRAN
JI Int. J. Heat Mass Transf.
PD DEC
PY 2014
VL 79
BP 720
EP 726
DI 10.1016/j.ijheatmasstransfer.2014.08.054
PG 7
WC Thermodynamics; Engineering, Mechanical; Mechanics
SC Thermodynamics; Engineering; Mechanics
GA AR7TE
UT WOS:000343781900070
ER
PT J
AU Florio, LA
AF Florio, L. A.
TI Computation of fluid-particle interactions with high-speed compressible
flows and multiple particles with deformation, plasticity, and
collisions
SO POWDER TECHNOLOGY
LA English
DT Article
DE Fluid structure interaction; Computational fluid dynamics; Soft
collision model; Particle flow; Plasticity; Deformation
ID SIMULATION; MODEL; ASSEMBLIES; VISCOSITY; BEHAVIOR; SPHERES; NUMBER
AB Two phase direct particle-high speed compressible gas flow simulation techniques developed by the author are extended to include the effects of particle deformation and plasticity with a focus on high speed impact of metallic steel particles moving in high speed air. The first part of the study involves the development of the necessary modeling techniques. Using the results of fluid independent finite element analyses, normal force functions were devised to simulate the effect of a collision of two 1.5 mm radius steel particles over a range of relative impact velocities from 12.5 to 200 m/s with an elastic and then an elastic perfectly plastic material model. Methods were introduced to model the deformation of the particles/objects. Use of the collision force model and the inclusion of deformation in a simulation of the collision between two particles in air replicated the appropriate short term post collision velocities of the corresponding finite element analysis. The parametric studies conducted during this model development demonstrated the importance of utilizing the proper material model in predicting the motion of the particles. A longer contact time and increasingly comparable post collision velocities for the two colliding particles develop with an elastic perfectly plastic based collision model, with the differences from the elastic based model results growing with collision velocity. The modeling techniques were then applied to analyze the motion of fourteen steel particles placed ahead of a gas driven piston in a flow channel 19.5 mm in width for three different piston driving pressures of 50, 75, and 100 MPa, implementing the elastic and then the elastic plastic based collision force models. The results clearly indicate that the incorporation of plasticity and particle deformation causes the particles to remain closer together both inside and outside of the flow channel. The modeling methods developed provide the ability to incorporate the plasticity/deformation effects of multiple interacting particles together with the local flow induced force to simulate the coupled gas flow and particle motion. The techniques developed offer a tool to capture more of the physical phenomena occurring in the two phase flow regime of interest, extending the capabilities to simulate the motion of gas-particles to a wider range of particle and flow velocities and providing information to assist in the understanding of particle motion and interaction characteristics. Published by Elsevier B.V.
C1 US Army ARDEC, Technol Branch, Small Caliber Armaments Div, Picatinny Arsenal, NJ 07806 USA.
RP Florio, LA (reprint author), US Army ARDEC, Technol Branch, Small Caliber Armaments Div, Picatinny Arsenal, NJ 07806 USA.
EM laurie.a.florio.civ@mail.mil
FU ARDEC In-House Laboratory Independent Research Project
FX This work was funded by an ARDEC In-House Laboratory Independent
Research Project.
NR 29
TC 4
Z9 4
U1 1
U2 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0032-5910
EI 1873-328X
J9 POWDER TECHNOL
JI Powder Technol.
PD DEC
PY 2014
VL 268
BP 19
EP 37
DI 10.1016/j.powtec.2014.07.012
PG 19
WC Engineering, Chemical
SC Engineering
GA AR8WR
UT WOS:000343852700003
ER
PT J
AU Grujicic, M
Yavari, R
Snipes, JS
Ramaswami, S
Yen, CF
Cheeseman, BA
AF Grujicic, M.
Yavari, R.
Snipes, J. S.
Ramaswami, S.
Yen, C. -F.
Cheeseman, B. A.
TI The effect of plain-weaving on the mechanical properties of warp and
weft p-phenylene terephthalamide (PPTA) fibers/yarns
SO JOURNAL OF MATERIALS SCIENCE
LA English
DT Article
ID VINYL-ESTER-EPOXY; LEVEL ANALYSIS; ARAMID FIBERS; MODEL; PERFORMANCE;
STRENGTH; POLYUREA; ARMOR; VERIFICATION; WAVE
AB Coarse-grained molecular statics/dynamics methods are first used to investigate degradation in the PPTA fiber/yarn tensile strength, as a result of the prior compressive or tensile loading. PPTA fibers/yarns experience this type of loading in the course of a plain-weaving process, the process which is used in the fabrication of ballistic fabric and flexible armor. The more common all-atom molecular simulations were not used to assess strength degradation for two reasons: (a) the size of the associated computational domain rendering reasonable run-times would be too small and (b) modeling of the mechanical response of multi-fibril PPTA fibers could not be carried out (again due to the limited size of the computational domain). However, all-atom simulations were used to (a) define the coarse-grained particles (referred to as "beads") and (b) parameterize various components of the bead/bead force-field functions. In the second portion of the work, a simplified finite-element analysis of the plain-weaving process is carried out in order to assess the extent of tensile-strength degradation in warp and weft yarns during the weaving process. In this analysis, a new material model is used for the PPTA fibers/yarns. Specifically, PPTA is considered to be a linearly elastic, transversely isotropic material with degradable longitudinal-tensile strength and the longitudinal Young's modulus. Equations governing damage and strength/stiffness degradation in this material model are derived and parameterized using the coarse-grained simulation results. Lastly, the finite-element results are compared with their experimental counterparts, yielding a decent agreement.
C1 [Grujicic, M.; Yavari, R.; Snipes, J. S.; Ramaswami, S.] Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA.
[Yen, C. -F.; Cheeseman, B. A.] Weap & Mat Res Directorate, Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, 241 Engn Innovat Bldg, Clemson, SC 29634 USA.
EM gmica@clemson.edu
FU Army Research Office [W911NF-09-1-0513, W911NF-11-1-0207,
W911NF-11-1-0518]
FX The material presented in this paper is based on work supported by three
Army Research Office sponsored grants entitled "Multi-length Scale
Material Model Development for Armor-grade Composites" (Contract Number
W911NF-09-1-0513), "Friction Stir Welding Behavior of Selected 2000-
series and 5000-series Aluminum Alloys" (Contract Number
W911NF-11-1-0207), and "Concept Validation and Optimization for a
Vent-based Mine-blast Mitigation System" (Contract Number
W911NF-11-1-0518). The authors are indebted to Dr. Ralph A. Anthenien,
Jr., and Dr. Bryan J. Glaz of ARO for their continuing support and
interest in the present work.
NR 40
TC 6
Z9 6
U1 5
U2 44
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0022-2461
EI 1573-4803
J9 J MATER SCI
JI J. Mater. Sci.
PD DEC
PY 2014
VL 49
IS 24
BP 8272
EP 8293
DI 10.1007/s10853-014-8536-1
PG 22
WC Materials Science, Multidisciplinary
SC Materials Science
GA AQ0DO
UT WOS:000342453000007
ER
PT J
AU Lian, H
Du, P
Li, YZ
Liang, H
AF Lian, Heng
Du, Pang
Li, YuanZhang
Liang, Hua
TI Partially linear structure identification in generalized additive models
with NP-dimensionality
SO COMPUTATIONAL STATISTICS & DATA ANALYSIS
LA English
DT Article
DE Model structure identification; NP-dimensionality; Partially linear
structure; Polynomial splines; Quasi-likelihood
ID NONCONCAVE PENALIZED LIKELIHOOD; VARIABLE SELECTION; ORACLE PROPERTIES;
REGRESSION; LASSO
AB Separation of the linear and nonlinear components in additive models based on penalized likelihood has received attention recently. However, it remains unknown whether consistent separation is possible in generalized additive models, and how high dimensionality is allowed. In this article, we study the doubly SCAD-penalized approach for partial linear structure identification problems of non-polynomial (NP) dimensionality and demonstrate its oracle property. In particular, if the number of nonzero components is fixed, the dimensionality of the total number of components can be of order exp{n(d/(2d+1))} where d is the smoothness of the component functions. Under such dimensionality assumptions, we show that with probability approaching one, the proposed procedure can correctly identify the zero, linear, and nonlinear components in the model. We further establish the convergence rate of the estimator for the nonlinear component and the asymptotic normality of the estimator for the linear component. Performance of the proposed method is evaluated by simulation studies. The methods are demonstrated by analyzing a gene data set. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Lian, Heng] Nanyang Technol Univ, Sch Phys & Math Sci, Div Math Sci, Singapore 637371, Singapore.
[Du, Pang] Virginia Tech, Dept Stat, Blacksburg, VA 24060 USA.
[Li, YuanZhang] Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD USA.
[Liang, Hua] George Washington Univ, Dept Stat, Washington, DC 20052 USA.
RP Liang, H (reprint author), George Washington Univ, Dept Stat, Washington, DC 20052 USA.
EM HengLian@ntu.edu.sg; pangdu@vt.edu; hliang@gwu.edu
OI Lian, Heng/0000-0002-6008-6614
FU Singapore MOE Tier 1 Grant; NSF [DMS-1007126, DMS-1207444]; National
Natural Science Foundation of China [11228103]
FX The authors thank the AE and two reviewers for their insightful comments
and suggestions that lead to significant improvement of the manuscript.
Lian's research was supported by a Singapore MOE Tier 1 Grant. Du's
research was supported by the NSF grant DMS-1007126. Liang's research
was partially supported by NSF grant DMS-1207444 and by Award Number
11228103, given by the National Natural Science Foundation of China. The
views expressed are those of the authors and should not be construed to
represent the positions of the Department of the Army or Department of
Defense. None of the authors have any associations, financial or
otherwise, that may present a conflict of interest.
NR 21
TC 1
Z9 1
U1 0
U2 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0167-9473
EI 1872-7352
J9 COMPUT STAT DATA AN
JI Comput. Stat. Data Anal.
PD DEC
PY 2014
VL 80
BP 197
EP 208
DI 10.1016/j.csda.2014.06.021
PG 12
WC Computer Science, Interdisciplinary Applications; Statistics &
Probability
SC Computer Science; Mathematics
GA AO4YC
UT WOS:000341346300017
ER
PT J
AU Allen, JL
Borodin, O
Seo, DM
Henderson, WA
AF Allen, Joshua L.
Borodin, Oleg
Seo, Daniel M.
Henderson, Wesley A.
TI Combined quantum chemical/Raman spectroscopic analyses of Li+ cation
solvation: Cyclic carbonate solvents-Ethylene carbonate and propylene
carbonate
SO JOURNAL OF POWER SOURCES
LA English
DT Article
DE Battery; Electrolyte; Solvation number; Ethylene carbonate; Propylene
carbonate; Raman spectroscopy
ID NONAQUEOUS ELECTROLYTE-SOLUTIONS; LITHIUM PERCHLORATE; RAMAN-SPECTRA;
CONCENTRATED-SOLUTIONS; TRANSPORT-PROPERTIES; GAMMA-BUTYROLACTONE; ION
ASSOCIATION; LOCAL-STRUCTURE; LIQUID-PHASES; AB-INITIO
AB Combined computational/Raman spectroscopic analyses of ethylene carbonate (EC) and propylene carbonate (PC) salvation interactions with lithium salts are reported. It is proposed that previously reported Raman analyses of (EC)(n)-LiX mixtures have utilized faulty assumptions. In the present studies, density functional theory (DFT) calculations have provided corrections in terms of both the scaling factors for the solvent's Raman band intensity variations and information about band overlap. By accounting for these factors, the salvation numbers obtained from two different EC solvent bands are in excellent agreement with one another. The same analysis for PC, however, was found to be quite challenging. Commercially available PC is a racemic mixture of (S)- and (R)-PC isomers. Based upon the quantum chemistry calculations, each of these solvent isomers may exist as multiple conformers due to a low energy barrier for ring inversion, making deconvolution of the Raman bands daunting and inherently prone to significant error. Thus, Raman spectroscopy is able to accurately determine the extent of the EC ... Li+ cation salvation interactions using the provided methodology, but a similar analysis of PC ... Li+ cation salvation results in a significant underestimation of the actual salvation numbers. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Allen, Joshua L.; Seo, Daniel M.; Henderson, Wesley A.] N Carolina State Univ, Ion Liquids & Electrolytes Energy Technol ILEET L, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA.
[Allen, Joshua L.; Borodin, Oleg] US Army Res Lab, Electrochem Branch, Adelphi, MD 20783 USA.
[Henderson, Wesley A.] Pacific NW Natl Lab, Energy & Environm Directorate, Electrochem Mat & Syst Grp, Richland, WA 99352 USA.
RP Henderson, WA (reprint author), Pacific NW Natl Lab, Energy & Environm Directorate, Electrochem Mat & Syst Grp, Richland, WA 99352 USA.
EM oleg.a.borodin.civ@mail.mil; Wesley.Henderson@pnnl.gov
RI Borodin, Oleg/B-6855-2012
OI Borodin, Oleg/0000-0002-9428-5291
FU U.S. DOE BATT Program [DE-AC02-05-CH11231, DE-IA01-11EE003413]; U.S.
DOE, Office of Basic Energy Sciences, Division of Materials Sciences and
Engineering [DE-SC0002169]; SMART Graduate Research Fellowship by the
SMART Scholarship Program; American Society for Engineering Education
(ASEE)
FX This work was funded by the U.S. DOE BATT Program (contract number
DE-AC02-05-CH11231) for the experimental work related to the pure
solvents, the U.S. DOE, Office of Basic Energy Sciences, Division of
Materials Sciences and Engineering (contract number DE-SC0002169) for
the experimental work related to the solvent-lithium salt electrolytes
and the U.S. DOE BATT Program (contract number DE-IA01-11EE003413
through an Interagency Agreement between the U.S. DOE ABR program and
the U.S. Army Research Laboratory (ARL)) for the computational work.
J.L.A. is grateful for the award of a SMART Graduate Research Fellowship
by the SMART Scholarship Program and the American Society for
Engineering Education (ASEE).
NR 37
TC 19
Z9 19
U1 6
U2 140
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-7753
EI 1873-2755
J9 J POWER SOURCES
JI J. Power Sources
PD DEC 1
PY 2014
VL 267
BP 821
EP 830
DI 10.1016/j.jpowsour.2014.05.107
PG 10
WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials
Science, Multidisciplinary
SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science
GA AM1JI
UT WOS:000339601800098
ER
PT J
AU Terrill, WA
AF Terrill, W. Andrew
TI The Battle for Syria: 1918-1920
SO MIDDLE EAST JOURNAL
LA English
DT Book Review
C1 [Terrill, W. Andrew] US Army War Coll, Carlisle, PA 17013 USA.
RP Terrill, WA (reprint author), US Army War Coll, Carlisle, PA 17013 USA.
NR 1
TC 0
Z9 0
U1 0
U2 3
PU MIDDLE EAST INST
PI WASHINGTON
PA 1761 N ST NW, CIRCULATION DEPT, WASHINGTON, DC 20036-2882 USA
SN 0026-3141
J9 MIDDLE EAST J
JI Middle East J.
PD WIN
PY 2014
VL 68
IS 1
BP 175
EP 176
PG 2
WC Area Studies
SC Area Studies
GA AG2UD
UT WOS:000335271700020
ER
PT J
AU Knorr, DB
Williams, KS
Baril, NF
Weiland, C
Andzelm, JW
Lenhart, JL
Woicik, JC
Fischer, DA
Tidrow, MZ
Bandara, SV
Henry, NC
AF Knorr, Daniel B., Jr.
Williams, Kristen S.
Baril, Neil F.
Weiland, Conan
Andzelm, Jan W.
Lenhart, Joseph L.
Woicik, Joseph C.
Fischer, Daniel A.
Tidrow, Meimei Z.
Bandara, Sumith V.
Henry, Nathan C.
TI Use of 3-aminopropyltriethoxysilane deposited from aqueous solution for
surface modification of III-V materials
SO APPLIED SURFACE SCIENCE
LA English
DT Article
DE III/V materials; Aminopropylsilane; Surface passivation; NEXAFS; XPS;
InAs; GaSb
ID RAY PHOTOELECTRON-SPECTRA; SELF-ASSEMBLED MONOLAYERS; CHEMICAL DEPTH
PROFILE; SUPERLATTICE PHOTODIODES; GEOMETRY OPTIMIZATION; HYDROGEN
ADSORPTION; MOLECULAR-STRUCTURE; SULFUR PASSIVATION; CO2 ADSORPTION; XPS
METHOD
AB Focal plane arrays of strained layer superlattices (SLSs) composed of InAs/GaSb are excellent candidates for infrared imaging, but one key factor limiting their utility is the lack of a surface passivation technique capable of protecting the mesa sidewall from degradation. Along these lines, we demonstrate the use of aqueous 3-aminopropyl triethoxysilane (APTES) deposited as a surface functionalizing agent for subsequent polymer passivation on InAs and GaSb surfaces following a HCl/citric acid procedure to remove the conductive oxide In2O3. Using atomic force microscopy, variable angle spectroscopic ellipsometry, X-ray photoelectron spectroscopy (XPS), near-edge X-ray absorption fine structure (NE)(AFS), and modeling with density functional theory (DFT), we demonstrate that APTES films can successfully be deposited on III-V substrates by spin coating and directly compare these films to those deposited on silicon substrates. The HCl/citric acid surface preparation treatment is particularly effective at removing In2O3 without the surface segregation of In oxides observed from use of HCl alone. However, HCl/citric acid surface treatment method does result in heavy oxidation of both Ga and Sb, accompanied by segregation of Ga oxide to the surface. Deposited APTES layer thickness did not depend on the substrate choice, and thicknesses between 1 and 20 nm were obtained for APTES solution concentrations ranging from 0.1 to 2.5 vol %. XPS results for the N1s band of APTES showed that the content of ionic nitrogen was high (similar to 50%) for the thinnest films (similar to 1 nm), and decreased with increasing film thickness. These results indicate that APTES can indeed be used to form a silane surface layer to cover III-V materials substrates. Such APTES silane layers may prove useful in surface passivation of these materials alone, or as surface functionalizing agents for subsequent covalent binding with polymer overlayers like polyimide. Published by Elsevier B.V.
C1 [Knorr, Daniel B., Jr.; Williams, Kristen S.; Andzelm, Jan W.; Lenhart, Joseph L.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Baril, Neil F.; Tidrow, Meimei Z.; Bandara, Sumith V.; Henry, Nathan C.] US Army, RDECOM, CERDEC, NVSED, Ft Belvoir, VA 22060 USA.
[Weiland, Conan; Lenhart, Joseph L.; Woicik, Joseph C.] NIST, Gaithersburg, MD 20899 USA.
[Henry, Nathan C.] Corbin Co, Alexandria, VA 22314 USA.
RP Knorr, DB (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM daniel.knorr.civ@mail.mil; joseph.l.lenhart.civ@mail.mil
RI Weiland, Conan/K-4840-2012
FU U.S. Army Research Laboratory; U.S. Army Communications-Electronics
Research Development and Engineering Center CDIF program; U.S.
Department of Energy, Office of Science, Office of Basic Energy Sciences
[DE-AC02-98CH10886]; Postgraduate Research Participation Program at the
U.S. Army Research Laboratory (USARL); U.S. Department of Energy; USARL;
DoD High Performance Computing Modernization Programs at the U.S. Army
Research Laboratory; U.S. Air Force Research Laboratory DoD
Supercomputing Resource Centers
FX This work was supported by the U.S. Army Research Laboratory and the
U.S. Army Communications-Electronics Research Development and
Engineering Center CDIF program. Use of the National Synchrotron Light
Source, Brookhaven National Laboratory, was supported by the U.S.
Department of Energy, Office of Science, Office of Basic Energy
Sciences, under Contract No. DE-AC02-98CH10886. K. W. was supported in
part by an appointment to the Postgraduate Research Participation
Program at the U.S. Army Research Laboratory (USARL) administered by the
Oak Ridge Institute for Science and Education through an interagency
agreement between the U.S. Department of Energy and USARL. Modeling
studies were supported in part by grants of computer time from the DoD
High Performance Computing Modernization Programs at the U.S. Army
Research Laboratory and U.S. Air Force Research Laboratory DoD
Supercomputing Resource Centers.
NR 66
TC 2
Z9 2
U1 8
U2 55
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0169-4332
EI 1873-5584
J9 APPL SURF SCI
JI Appl. Surf. Sci.
PD NOV 30
PY 2014
VL 320
BP 414
EP 428
DI 10.1016/j.apsusc.2014.09.055
PG 15
WC Chemistry, Physical; Materials Science, Coatings & Films; Physics,
Applied; Physics, Condensed Matter
SC Chemistry; Materials Science; Physics
GA AU1SG
UT WOS:000345399900054
ER
PT J
AU Peddada, LY
Garbuzenko, OB
Devore, DI
Minko, T
Roth, CM
AF Peddada, Lavanya Y.
Garbuzenko, Olga B.
Devore, David I.
Minko, Tamara
Roth, Charles M.
TI Delivery of antisense oligonucleotides using poly(alkylene
oxide)-poly(propylacrylic acid) graft copolymers in conjunction with
cationic liposomes
SO JOURNAL OF CONTROLLED RELEASE
LA English
DT Article
DE Antisense; Gene silencing; Nanoparticle; Drug delivery; Self assembly;
Tumor
ID GENE-DELIVERY; INTRACELLULAR DELIVERY; POLYMERIC NANOPARTICLES; SERUM
STABILITY; NUCLEIC-ACIDS; IN-VIVO; CANCER; THERAPY; COMPLEXES; TUMOR
AB The clinical application of gene silencing is hindered by poor stability and low delivery efficiency of naked oligo-nucleotides. Here, we present the in vitro and in vivo behaviors of a rationally designed, ternary, self-assembled nanoparticle complex, consisting of an anionic copolymer, cationic DOTAP liposome, and antisense oligonucleotide (AON). The multifunctional copolymers are based on backbone poly(propylacrylic acid) (PPAA), a pH-sensitive hydrophobic polymer, with grafted poly(alkylene oxides) (PAOs) varying in extent of grafting and PAO chemistry. The nanoparticle complexes with PPAA-g-PAO copolymers enhance antisense gene silencing effects in A2780 human ovarian cancer cells. A greater amount of AON is delivered to ovarian tumor xenografts using the ternary copolymer-stabilized delivery system, compared to a binary DOTAP/AON complex, following intraperitoneal injection in mice. Further, intratumoral injection of the nanoparticle complexes containing 1 mol% grafted PAO reduced tumoral bcl-2 expression by up to 60%. The data for complexes across the set of PAO polymers support a strong role for the hydrophilic-lipophilic balance of the graft copolymer in achieving serum stability and cellular uptake. Based upon these results, we anticipate that this novel nanoparticle delivery system can be extended to the delivery of plasmid DNA, siRNA, or aptamers for preclinical and clinical development. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Peddada, Lavanya Y.; Roth, Charles M.] Rutgers State Univ, Dept Biomed Engn, Piscataway, NJ USA.
[Garbuzenko, Olga B.; Minko, Tamara] Rutgers State Univ, Dept Pharmaceut, Piscataway, NJ USA.
[Roth, Charles M.] Rutgers State Univ, Dept Chem & Biochem Engn, Piscataway, NJ USA.
[Devore, David I.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
RP Roth, CM (reprint author), 599 Taylor Rd, Piscataway, NJ 08854 USA.
EM cmroth@rutgers.edu
OI Roth, Charles/0000-0002-4924-0721
FU NIH [2R01 EB008278]; New Jersey Commission for Cancer Research
FX We gratefully acknowledge financial support from NIH Grant 2R01 EB008278
and a fellowship from the New Jersey Commission for Cancer Research to
LP. We thank Professor Joachim Kohn for access to polymer synthesis
facilities at the New Jersey Center for Biomaterials and are indebted to
Drs. Abraham Joy and Marius Costache for their assistance with polymer
synthesis and characterization. The opinions or assertions contained
herein are the private views of the authors and are not to be construed
as official or as reflecting the views of the Department of the Army or
the Department of Defense.
NR 56
TC 9
Z9 9
U1 4
U2 48
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0168-3659
EI 1873-4995
J9 J CONTROL RELEASE
JI J. Control. Release
PD NOV 28
PY 2014
VL 194
BP 103
EP 112
DI 10.1016/j.jconrel.2014.08.023
PG 10
WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy
SC Chemistry; Pharmacology & Pharmacy
GA AS4FU
UT WOS:000344229800010
PM 25192941
ER
PT J
AU Rutvisuttinunt, W
Chinnawirotpisan, P
Klungthong, C
Shrestha, SK
Thapa, AB
Pant, A
Yingst, SL
Yoon, IK
Fernandez, S
Pavlin, JA
AF Rutvisuttinunt, Wiriya
Chinnawirotpisan, Piyawan
Klungthong, Chonticha
Shrestha, Sanjaya Kumar
Thapa, Amod Bahadur
Pant, Arjun
Yingst, Samuel L.
Yoon, In-Kyu
Fernandez, Stefan
Pavlin, Julie A.
TI Evidence of West Nile virus infection in Nepal
SO BMC INFECTIOUS DISEASES
LA English
DT Article
DE West nile virus; Nepal; Febrile illness; Deep sequencing; NGS; Phylogeny
ID DYNAMICS; LINEAGE
AB Background: Acute febrile illness is common among those seeking medical care and is frequently treated empirically with the underlying illness remaining undiagnosed in resource-poor countries. A febrile illness study was conducted 2009-2010 to identify known and unknown pathogens circulating in Nepal.
Method: Study methods included diagnostic testing and preliminary ELISA screening of acute and convalescent samples for diseases both known and unknown to be circulating in Nepal, including West Nile virus (WNV). The molecular assays including Polymerase Chain Reaction (PCR), Sanger sequencing and ultra deep sequencing on MiSeq Illumina Platform were conducted to further confirm the presence of WNV.
Results: The study enrolled 2,046 patients presenting undifferentiated febrile illness with unknown etiology. Sera from 14 out of 2,046 patients were tested positive for west nile virus (WNV) by nested Reverse Transcription-Polymerase Chain Reaction (RT-PCR). Only two out of 14 cases were confirmed for the presence of WNV by sequencing and identified as WNV lineage 1 phylogentically. The two patients were adult males with fever and no neurological symptoms from Kathmandu and Bharatpur, Nepal.
Conclusion: Two out of 2,046 serum samples contained fragments of WNV genome resembling WNV lineage 1, which is evidence of the continued spread of WNV which should be considered a possible illness cause in Nepal.
C1 [Rutvisuttinunt, Wiriya; Chinnawirotpisan, Piyawan; Klungthong, Chonticha; Yingst, Samuel L.; Yoon, In-Kyu; Fernandez, Stefan] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
[Shrestha, Sanjaya Kumar] Walter Reed AFRIMS Res Unit Nepal, Kathmandu, Nepal.
[Thapa, Amod Bahadur] Bharatpur Hosp, Chitwan, Nepal.
[Pant, Arjun] Sukra Raj Trop Infect Dis Hosp, Kathmandu, Nepal.
[Pavlin, Julie A.] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD USA.
RP Rutvisuttinunt, W (reprint author), Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
EM wiriyar@afrims.org; julie.a.pavlin.civ@mail.mil
FU Armed Forces Health Surveillance Center - Global Emerging Infections
Surveillance and Response System (AFHSC-GEIS)
FX We would like to thank Armed Forces Health Surveillance Center - Global
Emerging Infections Surveillance and Response System (AFHSC-GEIS) for
financial support, staff at WARUN for subject enrolment, sample
processing and information management, staff at AFRIMS for clinical
information, processing WNV isolates and laboratory technical assistance
on nucleic acid measurement, and the bioinformatics team at Los Alamos
National Laboratory, Naval Medical Research Center and Prince of Songkla
University for Bioinformatics consultation. The views expressed in this
article are those of the authors and do not represent the official
policy or position of the US Department of the Army, Department of
Defense, or US Government.
NR 16
TC 2
Z9 2
U1 0
U2 4
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2334
J9 BMC INFECT DIS
JI BMC Infect. Dis.
PD NOV 27
PY 2014
VL 14
AR 606
DI 10.1186/s12879-014-0606-0
PG 6
WC Infectious Diseases
SC Infectious Diseases
GA AZ5CC
UT WOS:000348236800001
PM 25427544
ER
PT J
AU Seo, DM
Boyle, PD
Sommer, RD
Daubert, JS
Borodin, O
Henderson, WA
AF Seo, Daniel M.
Boyle, Paul D.
Sommer, Roger D.
Daubert, James S.
Borodin, Oleg
Henderson, Wesley A.
TI Solvate Structures and Spectroscopic Characterization of LiTFSI
Electrolytes
SO JOURNAL OF PHYSICAL CHEMISTRY B
LA English
DT Article
ID BIS(TRIFLUOROMETHANESULFONYL) IMIDE ANION; IONIC LIQUID; LITHIUM-ION;
PHASE-BEHAVIOR; 1-BUTYL-3-METHYLIMIDAZOLIUM
BIS(TRIFLUOROMETHANESULFONYL)IMIDE; COMPUTATIONAL/SPECTROSCOPIC
CHARACTERIZATION; POLYMER ELECTROLYTES; TRANSPORT-PROPERTIES;
RAMAN-SPECTROSCOPY; DFT CALCULATIONS
AB A Raman spectroscopic evaluation of numerous crystalline solvates with lithium bis(trifluoromethanesulfonyl)imide (LiTFSI or LiN(SO2CF3)(2)) has been conducted over a wide temperature range. Four new crystalline solvate structures-(PHEN)(3):LiTFSI, (2,9-DMPHEN)(2):LiTFSI, (G3)(1):LiTFSI and (2,6-DMPy)(1/2):LiTFSI with phenanthroline, 2,9-dimethyl[1,10]phenanthroline, triglyme, and 2,6-dimethylpyridine, respectively-have been determined to aid in this study. The spectroscopic data have been correlated with varying modes of TFSI-center dot center dot center dot Li+ cation coordination within the solvate structures to create an electrolyte characterization tool to facilitate the Raman band deconvolution assignments for the determination of ionic association interactions within electrolytes containing LiTFSI. It is found, however, that significant difficulties may be encountered when identifying the distributions of specific forms of TFSI- anion coordination present in liquid electrolyte mixtures due to the wide range of TFSI-center dot center dot center dot Li+ cation interactions possible and the overlap of the corresponding spectroscopic data signatures.
C1 [Seo, Daniel M.; Daubert, James S.; Henderson, Wesley A.] N Carolina State Univ, Dept Chem & Biomol Engn, Ion Liquids & Elect Energy Technol ILEET Lab, Raleigh, NC 27695 USA.
[Boyle, Paul D.; Sommer, Roger D.] N Carolina State Univ, Dept Chem, Xray Struct Facil, Raleigh, NC 27695 USA.
[Borodin, Oleg] US Army Res Lab, Electrochem Branch, Adelphi, MD 20783 USA.
[Henderson, Wesley A.] PNNL, Electrochem Mat & Syst Grp, Energy & Environm Directorate, Richland, WA 99352 USA.
RP Henderson, WA (reprint author), N Carolina State Univ, Dept Chem & Biomol Engn, Ion Liquids & Elect Energy Technol ILEET Lab, Raleigh, NC 27695 USA.
EM Wesley.Henderson@pnnl.gov
RI Borodin, Oleg/B-6855-2012;
OI Borodin, Oleg/0000-0002-9428-5291; Daubert, James/0000-0002-8151-9191
FU U.S. Department of Energy (DOE) Office of Basic Energy Science-Division
of Materials Sciences and Engineering [DE-SC0002169]
FX The authors wish to express their gratitude to the U.S. Department of
Energy (DOE) Office of Basic Energy Science-Division of Materials
Sciences and Engineering which fully supported the experimental research
under Award DE-SC0002169.
NR 44
TC 20
Z9 20
U1 7
U2 58
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1520-6106
J9 J PHYS CHEM B
JI J. Phys. Chem. B
PD NOV 27
PY 2014
VL 118
IS 47
SI SI
BP 13601
EP 13608
DI 10.1021/jp505006x
PG 8
WC Chemistry, Physical
SC Chemistry
GA AU6OU
UT WOS:000345722900035
PM 25345716
ER
PT J
AU Hooper, JW
Brocato, RL
Kwilas, SA
Hammerbeck, CD
Josleyn, MD
Royals, M
Ballantyne, J
Wu, H
Jiao, JA
Matsushita, H
Sullivan, EJ
AF Hooper, Jay W.
Brocato, Rebecca L.
Kwilas, Steven A.
Hammerbeck, Christopher D.
Josleyn, Matthew D.
Royals, Michael
Ballantyne, John
Wu, Hua
Jiao, Jin-an
Matsushita, Hiroaki
Sullivan, Eddie J.
TI DNA vaccine-derived human IgG produced in transchromosomal bovines
protect in lethal models of hantavirus pulmonary syndrome
SO SCIENCE TRANSLATIONAL MEDICINE
LA English
DT Article
ID SIN-NOMBRE-VIRUS; NEUTRALIZING ANTIBODY-RESPONSE; TO-PERSON
TRANSMISSION; ANDES VIRUS; UNITED-STATES; INCUBATION PERIOD;
NONHUMAN-PRIMATES; SYRIAN-HAMSTERS; RHESUS MACAQUES; DISEASE-MODEL
AB Polyclonal immunoglobulin-based medical products have been used successfully to treat diseases caused by viruses for more than a century. We demonstrate the use of DNA vaccine technology and transchromosomal bovines (TcBs) to produce fully human polyclonal immunoglobulins (IgG) with potent antiviral neutralizing activity. Specifically, two hantavirus DNA vaccines [Andes virus (ANDV) DNA vaccine and Sin Nombre virus (SNV) DNA vaccine] were used to produce a candidate immunoglobulin product for the prevention and treatment of hantavirus pulmonary syndrome (HPS). A needle-free jet injection device was used to vaccinate TcB, and high-titer neutralizing antibodies (titers >1000) against both viruses were produced within 1 month. Plasma collected at day 10 after the fourth vaccination was used to produce purified alpha-HPS TcB human IgG. Treatment with 20,000 neutralizing antibody units (NAU)/kg starting 5 days after challenge with ANDV protected seven of eight animals, whereas zero of eight animals treated with the same dose of normal TcB human IgG survived. Likewise, treatment with 20,000 NAU/kg starting 5 days after challenge with SNV protected immunocompromised hamsters from lethal HPS, protecting five of eight animals. Our findings that the alpha-HPS TcB human IgG is capable of protecting in animal models of lethal HPS when administered after exposure provides proof of concept that this approach can be used to develop candidate next-generation polyclonal immunoglobulin-based medical products without the need for human donors, despeciation protocols, or inactivated/attenuated vaccine antigen.
C1 [Hooper, Jay W.; Brocato, Rebecca L.; Kwilas, Steven A.; Hammerbeck, Christopher D.; Josleyn, Matthew D.] US Army Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21709 USA.
[Royals, Michael] Cedar Ind, Pierce, CO 80650 USA.
[Wu, Hua; Jiao, Jin-an; Matsushita, Hiroaki; Sullivan, Eddie J.] SAB Biotherapeut Inc, Sioux Falls, SD 57104 USA.
RP Hooper, JW (reprint author), US Army Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21709 USA.
EM jay.w.hooper.civ@mail.mil
OI Hooper, Jay/0000-0002-4475-0415
FU internal SAB funding; Military Infectious Disease Research Program,
Program Area T
FX This work was supported by internal SAB funding and by funding from the
Military Infectious Disease Research Program, Program Area T.
NR 50
TC 10
Z9 10
U1 0
U2 11
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 1946-6234
EI 1946-6242
J9 SCI TRANSL MED
JI Sci. Transl. Med.
PD NOV 26
PY 2014
VL 6
IS 264
AR 264ra162
DI 10.1126/scitranslmed.3010082
PG 9
WC Cell Biology; Medicine, Research & Experimental
SC Cell Biology; Research & Experimental Medicine
GA AU4PY
UT WOS:000345595200002
PM 25429055
ER
PT J
AU Li, W
Birdwell, AG
Amani, M
Burke, RA
Ling, X
Lee, YH
Liang, XL
Peng, LM
Richter, CA
Kong, J
Gundlach, DJ
Nguyen, NV
AF Li, Wei
Birdwell, A. Glen
Amani, Matin
Burke, Robert A.
Ling, Xi
Lee, Yi-Hsien
Liang, Xuelei
Peng, Lianmao
Richter, Curt A.
Kong, Jing
Gundlach, David J.
Nguyen, N. V.
TI Broadband optical properties of large-area monolayer CVD molybdenum
disulfide
SO PHYSICAL REVIEW B
LA English
DT Article
ID SINGLE-LAYER MOS2; CHEMICAL-VAPOR-DEPOSITION; HIGH-QUALITY MONOLAYER;
ELECTRONIC-STRUCTURE; ATOMIC LAYERS; BILAYER MOS2; SOLAR-CELLS;
PHOTOLUMINESCENCE; PHOTOTRANSISTORS; TRANSISTORS
AB Recently emerging large-area single-layer MoS2 grown by chemical vapor deposition has triggered great interest due to its exciting potential for applications in advanced electronic and optoelectronic devices. Unlike gapless graphene, MoS2 has an intrinsic band gap in the visible which crosses over from an indirect to a direct gap when reduced to a single atomic layer. In this paper, we report a comprehensive study of fundamental optical properties of MoS2 revealed by optical spectroscopy of Raman, photoluminescence, and vacuum ultraviolet spectroscopic ellipsometry. A band gap of 1.42 eV is determined by the absorption threshold of bulk MoS2 that shifts to 1.83 eV in monolayer MoS2. We extracted the high precision dielectric function up to 9.0 eV, which leads to the identification of many unique interband transitions at high symmetry points in the MoS2 momentum space. The positions of the so-called A and B excitons in single layers are found to shift upwards in energy compared with those of the bulk form and have smaller separation because of the decreased interactions between the layers. A very strong optical critical point predicted to correspond to a quasiparticle gap is observed at 2.86 eV, which is attributed to optical transitions along the parallel bands between the M and Gamma points in the reduced Brillouin zone. The absence of the bulk MoS2 spin-orbit interaction peak at similar to 3.0 eV in monolayer MoS2 is, as predicted, the consequence of the coalescence of nearby excitons. A higher energy optical transition at 3.98 eV, commonly occurring in bulk semiconductors, is associated with a combination of several critical points. Additionally, extending into the vacuum ultraviolet energy spectrum are a series of newly observed oscillations representing optical transitions from valence bands to higher conduction bands of the monolayer MoS2 complex band structure. These optical transitions herein reported enhance our understanding of monolayer MoS2 as well as of two-dimensional systems in general and thus provide informative guidelines for MoS2 optical device designs and theoretical considerations.
C1 [Li, Wei; Richter, Curt A.; Gundlach, David J.; Nguyen, N. V.] NIST, Semicond & Dimens Metrol Div, Gaithersburg, MD 20899 USA.
[Li, Wei; Liang, Xuelei; Peng, Lianmao] Peking Univ, Key Lab Phys & Chem Nanodevices, Beijing 100871, Peoples R China.
[Li, Wei; Liang, Xuelei; Peng, Lianmao] Peking Univ, Dept Elect, Beijing 100871, Peoples R China.
[Birdwell, A. Glen; Amani, Matin; Burke, Robert A.] US Army, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA.
[Ling, Xi; Lee, Yi-Hsien; Kong, Jing] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA.
[Lee, Yi-Hsien] Natl Tsing Hua Univ, Hsinchu 30013, Taiwan.
RP Li, W (reprint author), NIST, Semicond & Dimens Metrol Div, Gaithersburg, MD 20899 USA.
EM liangxl@pku.edu.cn; nhan.nguyen@nist.gov
RI Peng, Lianmao/E-2089-2011; Liang, Xuelei/C-4690-2013
FU Ministry of Science and Technology of China (STC) [2011CB921904];
Ministry of education of China [113003A]; Natural Science Foundation
(NSF) of China [61321001]; Beijing Municipal Science and Technology
Commission [Z141100003814006]; National Institute of Standards and
Technology; STC Center for Integrated Quantum Materials from NSF
[DMR-1231319]; US Army Research Laboratory (ARL) Director's Strategic
Initiative program
FX This work was supported by the Ministry of Science and Technology of
China (STC) (Grant No. 2011CB921904), the Ministry of education of China
(Grant No. 113003A) Natural Science Foundation (NSF) of China (Grant No.
61321001), and Beijing Municipal Science and Technology Commission
(Grant No. Z141100003814006). W. L. was partly supported by the National
Institute of Standards and Technology. J.K. acknowledges the support
through the STC Center for Integrated Quantum Materials from NSF Grant
No. DMR-1231319. A.G.B., M.A., and R.A.B. were supported by the US Army
Research Laboratory (ARL) Director's Strategic Initiative program on
interfaces in stacked 2D atomic layered materials.
NR 50
TC 19
Z9 19
U1 6
U2 114
PU AMER PHYSICAL SOC
PI COLLEGE PK
PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA
SN 1098-0121
EI 1550-235X
J9 PHYS REV B
JI Phys. Rev. B
PD NOV 21
PY 2014
VL 90
IS 19
AR 195434
DI 10.1103/PhysRevB.90.195434
PG 8
WC Physics, Condensed Matter
SC Physics
GA AU6WS
UT WOS:000345742800005
ER
PT J
AU Nyenswah, T
Fahnbulleh, M
Massaquoi, M
Nagbe, T
Bawo, L
Falla, JD
Kohar, H
Gasasira, A
Nabeth, P
Yett, S
Gergonne, B
Casey, S
Espinosa, B
McCoy, A
Feldman, H
Hensley, L
Baily, M
Fields, B
Lo, T
Lindblade, K
Mott, J
Boulanger, L
Christie, A
Wang, SS
Montgomery, J
Mahoney, F
AF Nyenswah, Tolbert
Fahnbulleh, Miatta
Massaquoi, Moses
Nagbe, Thomas
Bawo, Luke
Falla, James Dorbor
Kohar, Henry
Gasasira, Alex
Nabeth, Pierre
Yett, Sheldon
Gergonne, Bernadette
Casey, Sean
Espinosa, Benjamin
McCoy, Andrea
Feldman, Heinz
Hensley, Lisa
Baily, Mark
Fields, Barry
Lo, Terrence
Lindblade, Kim
Mott, Josh
Boulanger, Lucy
Christie, Athalia
Wang, Susan
Montgomery, Joel
Mahoney, Frank
TI Ebola Epidemic - Liberia, March-October 2014
SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
LA English
DT Article
ID DISEASE OUTBREAK; VIRUS DISEASE
C1 [Nyenswah, Tolbert; Fahnbulleh, Miatta; Massaquoi, Moses; Nagbe, Thomas; Bawo, Luke; Falla, James Dorbor; Kohar, Henry] Minist Hlth & Social Welf, Monrovia, Liberia.
[Gasasira, Alex; Nabeth, Pierre] World Hlth Org, Geneva, Switzerland.
[Yett, Sheldon] United Nations Childrens Fund, New York, NY USA.
[Gergonne, Bernadette] Medecins Sans Frontieres, Geneva, Switzerland.
[Casey, Sean] Int Med Corps, Los Angeles, CA USA.
[Espinosa, Benjamin; McCoy, Andrea] US Navy, Pentagon, AR USA.
[Feldman, Heinz; Hensley, Lisa] Natl Inst Hlth, Bethesda, MD USA.
[Baily, Mark] US Army Med Res Inst Infect Dis, Ft Detroit, MD USA.
[Fields, Barry; Lo, Terrence; Lindblade, Kim; Mott, Josh; Boulanger, Lucy; Christie, Athalia; Wang, Susan; Montgomery, Joel; Mahoney, Frank] CDC, Atlanta, GA 30333 USA.
RP Mahoney, F (reprint author), CDC, Atlanta, GA 30333 USA.
EM fmahoney@cdc.gov
NR 5
TC 15
Z9 16
U1 0
U2 14
PU CENTER DISEASE CONTROL & PREVENTION
PI ATLANTA
PA MAILSTOP E-90, ATLANTA, GA 30333 USA
SN 0149-2195
EI 1545-861X
J9 MMWR-MORBID MORTAL W
JI MMWR-Morb. Mortal. Wkly. Rep.
PD NOV 21
PY 2014
VL 63
IS 46
BP 1082
EP 1086
PG 5
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA AU3LO
UT WOS:000345514900009
PM 25412068
ER
PT J
AU Nyenswah, T
Fahnbulleh, M
Ketah, F
Massaquoi, M
Nagbe, T
Bawo, L
Falla, JD
Kohar, H
Gasasira, A
Nabeth, P
Popowitz, H
Yett, S
Hurum, L
Sailly, L
Casey, S
Espinosa, B
Mccoy, A
Feldman, H
Hensley, L
Baily, M
Pendarvis, J
Fields, B
Lo, T
Quin, J
Aberle-Grasse, J
Lindblade, K
Mott, J
Boulanger, L
Christie, A
Wang, SS
Montgomery, J
Mahoney, F
AF Nyenswah, Tolbert
Fahnbulleh, Miatta
Ketah, Francis
Massaquoi, Moses
Nagbe, Thomas
Bawo, Luke
Falla, James Dorbor
Kohar, Henry
Gasasira, Alex
Nabeth, Pierre
Popowitz, Heather
Yett, Sheldon
Hurum, Lindis
Sailly, Laurence
Casey, Sean
Espinosa, Benjamin
McCoy, Andrea
Feldman, Heinz
Hensley, Lisa
Baily, Mark
Pendarvis, Justin
Fields, Barry
Lo, Terrence
Quin, Jin
Aberle-Grasse, John
Lindblade, Kim
Mott, Josh
Boulanger, Lucy
Christie, Athalia
Wang, Susan
Montgomery, Joel
Mahoney, Frank
TI Ebola Epidemic - Liberia, March-October 2014 (vol 63, pg 1082, 2014)
SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
LA English
DT Correction
C1 [Nyenswah, Tolbert; Fahnbulleh, Miatta; Ketah, Francis; Massaquoi, Moses; Nagbe, Thomas; Bawo, Luke; Falla, James Dorbor; Kohar, Henry] Minist Hlth & Social Welf, Monrovia, Liberia.
[Gasasira, Alex; Nabeth, Pierre] World Hlth Org, Geneva, Switzerland.
[Popowitz, Heather; Yett, Sheldon] United Nations Childrens Fund, New York, NY USA.
[Hurum, Lindis; Sailly, Laurence] Medecins Sans Frontieres, Geneva, Switzerland.
[Casey, Sean] Int Med Corps, Los Angeles, CA USA.
[Espinosa, Benjamin; McCoy, Andrea] US Navy, Pentagon, AR USA.
[Feldman, Heinz; Hensley, Lisa] Natl Inst Hlth, Atlanta, GA USA.
[Baily, Mark] US Army Med Res Inst Infect Dis, Ft Detroit, MD USA.
[Pendarvis, Justin] US Agcy Int Dev, Washington, DC 20523 USA.
[Fields, Barry; Lo, Terrence; Quin, Jin; Aberle-Grasse, John; Lindblade, Kim; Mott, Josh; Boulanger, Lucy; Christie, Athalia; Wang, Susan; Montgomery, Joel; Mahoney, Frank] CDC, Atlanta, GA 30333 USA.
RP Nyenswah, T (reprint author), Minist Hlth & Social Welf, Monrovia, Liberia.
NR 1
TC 2
Z9 2
U1 0
U2 3
PU CENTER DISEASE CONTROL & PREVENTION
PI ATLANTA
PA MAILSTOP E-90, ATLANTA, GA 30333 USA
SN 0149-2195
EI 1545-861X
J9 MMWR-MORBID MORTAL W
JI MMWR-Morb. Mortal. Wkly. Rep.
PD NOV 21
PY 2014
VL 63
IS 46
BP 1094
EP 1094
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA AU3LO
UT WOS:000345514900012
ER
PT J
AU Kester, KE
Heppner, DG
Moris, P
Ofori-Anyinam, O
Krzych, U
Tornieporth, N
McKinney, D
Delchambre, M
Ockenhouse, CF
Voss, G
Holland, C
Beckey, JP
Ballou, WR
Cohen, J
AF Kester, Kent E.
Heppner, D. Gray, Jr.
Moris, Philippe
Ofori-Anyinam, Opokua
Krzych, Urszula
Tornieporth, Nadia
McKinney, Denise
Delchambre, Martine
Ockenhouse, Christian F.
Voss, Gerald
Holland, Carolyn
Beckey, Jolie Palensky
Ballou, W. Ripley
Cohen, Joe
CA RTS
TRAP Grp
TI Sequential Phase 1 and Phase 2 randomized, controlled trials of the
safety, immunogenicity and efficacy of combined pre-erythrocytic vaccine
antigens RTS,S and TRAP formulated with AS02 Adjuvant System in healthy,
malaria naive adults
SO VACCINE
LA English
DT Article
DE TRAP; RTS,S; AS02; Immune interference; Malaria vaccine; Challenge
ID FALCIPARUM CIRCUMSPOROZOITE PROTEIN; SPOROZOITE SURFACE PROTEIN-2;
PRIME-BOOST IMMUNIZATION; INSTITUTE-OF-RESEARCH; CD4(+) T-CELL;
PLASMODIUM-FALCIPARUM; VIRUS ANKARA; RECOMBINANT PROTEIN;
ANTIBODY-RESPONSES; AFRICAN CHILDREN
AB In an attempt to improve the efficacy of the candidate malaria vaccine RTS,S/AS02, two studies were conducted in 1999 in healthy volunteers of RTS,S/AS02 in combination with recombinant Plasmodium falciparum thrombospondin-related anonymous protein (TRAP). In a Phase 1 safety and immunogenicity study, volunteers were randomized to receive TRAP/AS02 (N = 10), RTS,S/AS02 (N = 10), or RTS,S + TRAP/AS02 (N = 20) at 0,1 and 6-months. In a Phase 2 challenge study, subjects were randomized to receive either RTS,S + TRAP/AS02 (N = 25) or TRAP/AS02 (N = 10) at 0 and 1-month, or to a challenge control group (N = 8). In both studies, the combination vaccine had an acceptable safety profile and was acceptably tolerated. Antigen-specific antibodies, lymphoproliferative responses, and IFN-gamma production by ELISPOT assay elicited with the combination vaccine were qualitatively similar to those generated by the single component vaccines. However, post-dose 2 anti-CS antibodies in the RTS,S + TRAP/AS02 vaccine recipients were lower than in the RTS,S/AS02 vaccine recipients. After challenge, 10 of 11 RTS,S + TRAP/AS02 vaccinees, 5 of 5 TRAP/AS02 vaccinees, and 8 of 8 infectivity controls developed parasitemia, with median pre-patent periods of 13.0, 11.0, and 12.0 days, respectively. The absence of any prevention or delay of parasitemia by TRAP/AS02 suggests no apparent added value of TRAP/AS02 as a candidate vaccine. The absence of significant protection or delay of parasitemia in the 11 RTS,S + TRAP/AS02 vaccine recipients contrasts with previous 2 dose studies of RTS,S/AS02. The small sample size did not permit identifying statistically significant differences between the study arms. However, we speculate, within the constraints of the challenge study, that the presence of the TRAP antigen may have interfered with the vaccine efficacy previously observed with this regimen of RTS,S/AS02, and that any future TRAP-based vaccines should consider employing alternative vaccine platforms. (C) 2014 The Authors. Published by Elsevier Ltd.
C1 [Kester, Kent E.; Heppner, D. Gray, Jr.; Krzych, Urszula; McKinney, Denise; Ockenhouse, Christian F.; Holland, Carolyn; Ballou, W. Ripley] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Moris, Philippe; Ofori-Anyinam, Opokua; Tornieporth, Nadia; Delchambre, Martine; Voss, Gerald; Cohen, Joe] GlaxoSmithKline Biol, Rixensart, Belgium.
[Beckey, Jolie Palensky] Stat Collaborat Inc, Washington, DC USA.
RP Kester, KE (reprint author), Sanofi Pasteur, Discovery Dr, Swiftwater, PA 18370 USA.
EM kent.kester@usuhs.edu; grayheppner@gmail.com; philippe.moris@gsk.com;
opokua.ofori-anyinam@gsk.com; urszula.krzych1@us.army.mil;
nadia.tornieporth@sanofipasteur.com; deniseam52@gmail.com;
martine.delchambre@gsk.com; cockenhouse@path.org; gerald.voss@gsk.com;
carolyn.holland@us.army.mil; alexandjolie@gmail.com;
ripley.w.ballou@gsk.com; joe.cohen@gsk.com
FU GlaxoSmithKline Biologicals, Rixensart, Belgium; United States Army
Medical Materiel Development Activity, Ft. Detrick, Maryland
FX Financial support for the Phase I study was provided by GlaxoSmithKline
Biologicals, Rixensart, Belgium. Financial support for the Phase II
study was provided by the United States Army Medical Materiel
Development Activity, Ft. Detrick, Maryland, and by GlaxoSmithKline
Biologicals, Rixensart, Belgium.
NR 45
TC 9
Z9 9
U1 0
U2 4
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
EI 1873-2518
J9 VACCINE
JI Vaccine
PD NOV 20
PY 2014
VL 32
IS 49
BP 6683
EP 6691
DI 10.1016/j.vaccine.2014.06.033
PG 9
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA AU8BD
UT WOS:000345820800016
PM 24950358
ER
PT J
AU Barouch, DH
Michael, NL
AF Barouch, Dan H.
Michael, Nelson L.
TI Accelerating HIV-1 Vaccine Efficacy Trials
SO CELL
LA English
DT Editorial Material
ID DOUBLE-BLIND; GAG/POL/NEF VACCINE; HVTN 503/PHAMBILI; RHESUS-MONKEYS;
SOUTH-AFRICA; PHASE 2H; INFECTION; CHALLENGES
C1 [Barouch, Dan H.] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Ctr Virol & Vaccine Res, Boston, MA 02215 USA.
[Barouch, Dan H.] MIT, Ragon Inst MGH, Cambridge, MA 02139 USA.
[Barouch, Dan H.] Harvard, Cambridge, MA 02139 USA.
[Michael, Nelson L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA.
RP Barouch, DH (reprint author), Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Ctr Virol & Vaccine Res, Boston, MA 02215 USA.
EM dbarouch@bidmc.harvard.edu; nmichael@hivresearch.org
FU NIAID NIH HHS [R01 AI084794, U19 AI078526, U19 AI095985, U19 AI096040]
NR 13
TC 9
Z9 9
U1 2
U2 17
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0092-8674
EI 1097-4172
J9 CELL
JI Cell
PD NOV 20
PY 2014
VL 159
IS 5
BP 969
EP 972
DI 10.1016/j.cell.2014.10.046
PG 4
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA AU3IP
UT WOS:000345506300008
PM 25416935
ER
PT J
AU Ananworanich, J
Robb, ML
AF Ananworanich, Jintanat
Robb, Merlin L.
TI The transient HIV remission in the Mississippi baby: why is this good
news?
SO JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
LA English
DT Editorial Material
ID LATENT RESERVOIR; CURE
C1 [Ananworanich, Jintanat; Robb, Merlin L.] US Mil Acad, Walter Reed Army Inst Res, HIV Res Program, Silver Spring, MD USA.
[Ananworanich, Jintanat; Robb, Merlin L.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
RP Ananworanich, J (reprint author), US Mil Acad, HIV Res Program, 6720A Rockledge Dr,Suite 400, Bethesda, MD 20817 USA.
EM jananworanich@hivresearch.org
NR 13
TC 2
Z9 2
U1 1
U2 6
PU INT AIDS SOCIETY
PI GENEVA
PA AVENUE DE FRANCE 23, GENEVA, 1202, SWITZERLAND
SN 1758-2652
J9 J INT AIDS SOC
JI J. Int. AIDS Soc.
PD NOV 20
PY 2014
VL 17
AR 19859
DI 10.7448/IAS.17.1.19859
PG 2
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA AU3HB
UT WOS:000345501900001
PM 25416415
ER
PT J
AU Shaw, M
Yu, KM
Ting, M
Powell, REL
Sarney, WL
Svensson, SP
Kent, AJ
Walukiewicz, W
Foxon, CT
Novikov, SV
Martin, RW
AF Shaw, M.
Yu, K. M.
Ting, M.
Powell, R. E. L.
Sarney, W. L.
Svensson, S. P.
Kent, A. J.
Walukiewicz, W.
Foxon, C. T.
Novikov, S. V.
Martin, R. W.
TI Composition and optical properties of dilute-Sb GaN1-xSbx highly
mismatched alloys grown by MBE
SO JOURNAL OF PHYSICS D-APPLIED PHYSICS
LA English
DT Article
DE molecular beam epitaxy; nitrides; semiconducting III-V materials;
cathodoluminescence
ID MOLECULAR-BEAM EPITAXY; NITRIDE; BAND; GAN
AB In this work the compositional and optical characterization of three series of dilute-Sb GaN1-xSbx alloys grown with various Sb flux, under N and Ga-rich conditions, are presented. Using wavelength dispersive x-ray microanalysis and Rutherford backscattering spectroscopy it is found that the N-rich samples (Ga flux < 2.3 x 10(-7) Torr) incorporate a higher magnitude of GaSb than the Ga-rich samples (Ga flux > 2.3 x 10(-7) Torr) under the same growth conditions. The optical properties of the Ga-rich samples are measured using room temperature cathodoluminescence (CL), photoluminescence (PL) and absorption measurements. A broad luminescence peak is observed around 2.2 eV. The nature and properties of this peak are considered, as is the suitability of these dilute-Sb alloys for use in solar energy conversion devices.
C1 [Shaw, M.; Martin, R. W.] Univ Strathclyde, Dept Phys, SUPA, Glasgow G4 0NG, Lanark, Scotland.
[Yu, K. M.; Ting, M.; Walukiewicz, W.] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Mat Sci, Berkeley, CA 94720 USA.
[Ting, M.] Univ Calif Berkeley, Dept Mech Engn, Berkeley, CA 94720 USA.
[Powell, R. E. L.; Foxon, C. T.; Novikov, S. V.] Univ Nottingham, Sch Phys & Astron, Nottingham NG7 2RD, England.
[Sarney, W. L.; Svensson, S. P.] US Army, Res Lab, Adelphi, MD 20783 USA.
RP Shaw, M (reprint author), Univ Strathclyde, Dept Phys, SUPA, Glasgow G4 0NG, Lanark, Scotland.
EM martin.shaw@strath.ac.uk
RI martin, rob/A-7127-2010;
OI martin, rob/0000-0002-6119-764X; Kent, Anthony/0000-0002-2391-6869; Yu,
Kin Man/0000-0003-1350-9642
FU EPSRC UK [EP/I004203/1, EP/I00467X/1]; US Army Foreign Technology
Assessment Support (FTAS) program [W911NF-12-2-0003]; Office of Science,
Office of Basic Energy Sciences, Materials Sciences and Engineering
Division, of the US Department of Energy [DE-AC02-05CH11231]
FX This work was undertaken with support from the EPSRC UK, under grant
numbers EP/I004203/1 and EP/I00467X/1. The MBE growth at Nottingham was
also supported by the US Army Foreign Technology Assessment Support
(FTAS) program (grant W911NF-12-2-0003). The characterization work
performed at LBNL was supported by the Director, Office of Science,
Office of Basic Energy Sciences, Materials Sciences and Engineering
Division, of the US Department of Energy under Contract No.
DE-AC02-05CH11231. Data associated with research published in this paper
can be accessed by contacting the corresponding author.
NR 26
TC 3
Z9 3
U1 1
U2 9
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0022-3727
EI 1361-6463
J9 J PHYS D APPL PHYS
JI J. Phys. D-Appl. Phys.
PD NOV 19
PY 2014
VL 47
IS 46
AR 465102
DI 10.1088/0022-3727/47/46/465102
PG 7
WC Physics, Applied
SC Physics
GA AT3UG
UT WOS:000344859800003
ER
PT J
AU Wu, TYH
Singh, M
Miller, AT
De Gregorio, E
Doro, F
D'Oro, U
Skibinski, DAG
Mbow, ML
Bufali, S
Herman, AE
Cortez, A
Li, Y
Nayak, BP
Tritto, E
Filippi, CM
Otten, GR
Brito, LA
Monaci, E
Li, C
Aprea, S
Valentini, S
Calabro, S
Laera, D
Brunelli, B
Caproni, E
Malyala, P
Panchal, RG
Warren, TK
Bavari, S
O'Hagan, DT
Cooke, MP
Valiante, NM
AF Wu, Tom Y. -H.
Singh, Manmohan
Miller, Andrew T.
De Gregorio, Ennio
Doro, Francesco
D'Oro, Ugo
Skibinski, David A. G.
Mbow, M. Lamine
Bufali, Simone
Herman, Ann E.
Cortez, Alex
Li, Yongkai
Nayak, Bishnu P.
Tritto, Elaine
Filippi, Christophe M.
Otten, Gillis R.
Brito, Luis A.
Monaci, Elisabetta
Li, Chun
Aprea, Susanna
Valentini, Sara
Calabro, Samuele
Laera, Donatello
Brunelli, Brunella
Caproni, Elena
Malyala, Padma
Panchal, Rekha G.
Warren, Travis K.
Bavari, Sina
O'Hagan, Derek T.
Cooke, Michael P.
Valiante, Nicholas M.
TI Rational design of small molecules as vaccine adjuvants
SO SCIENCE TRANSLATIONAL MEDICINE
LA English
DT Article
ID SEROGROUP-B MENINGOCOCCUS; NEISSERIA-MENINGITIDIS; RESIQUIMOD;
IMMUNIZATION; AGONISTS; ASSAY; IDENTIFICATION; CANDIDATES; INFECTION;
DISCOVERY
AB Adjuvants increase vaccine potency largely by activating innate immunity and promoting inflammation. Limiting the side effects of this inflammation is a major hurdle for adjuvant use in vaccines for humans. It has been difficult to improve on adjuvant safety because of a poor understanding of adjuvant mechanism and the empirical nature of adjuvant discovery and development historically. We describe new principles for the rational optimization of small-molecule immune potentiators (SMIPs) targeting Toll-like receptor 7 as adjuvants with a predicted increase in their therapeutic indices. Unlike traditional drugs, SMIP-based adjuvants need to have limited bioavailability and remain localized for optimal efficacy. These features also lead to temporally and spatially restricted inflammation that should decrease side effects. Through medicinal and formulation chemistry and extensive immunopharmacology, we show that in vivo potency can be increased with little to no systemic exposure, localized innate immune activation and short in vivo residence times of SMIP-based adjuvants. This work provides a systematic and generalizable approach to engineering small molecules for use as vaccine adjuvants.
C1 [Wu, Tom Y. -H.; Miller, Andrew T.; Herman, Ann E.; Cortez, Alex; Li, Yongkai; Nayak, Bishnu P.; Filippi, Christophe M.; Li, Chun; Cooke, Michael P.] Novartis Fdn, Genom Inst, San Diego, CA 92121 USA.
[Singh, Manmohan; Mbow, M. Lamine; Otten, Gillis R.; Brito, Luis A.; Malyala, Padma; O'Hagan, Derek T.; Valiante, Nicholas M.] Novartis Vaccines, Cambridge, MA 02139 USA.
[De Gregorio, Ennio; Doro, Francesco; D'Oro, Ugo; Skibinski, David A. G.; Bufali, Simone; Tritto, Elaine; Monaci, Elisabetta; Aprea, Susanna; Valentini, Sara; Calabro, Samuele; Laera, Donatello; Brunelli, Brunella; Caproni, Elena] Novartis Vaccines, I-53100 Siena, Italy.
[Panchal, Rekha G.; Warren, Travis K.; Bavari, Sina] US Army Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
RP Valiante, NM (reprint author), Novartis Vaccines, 45 Sidney St, Cambridge, MA 02139 USA.
EM derek.ohagan@novartis.com; mcooke@gnf.org;
nicholas.valiante@novartis.com
FU Department of Defense Chemical and Biological Defense program through
the Defense Threat Reduction Agency [HDTRA1-07-9-0001]
FX This work was supported in part by the Transformational Medical
Technologies program contract HDTRA1-07-9-0001 from the Department of
Defense Chemical and Biological Defense program through the Defense
Threat Reduction Agency.
NR 39
TC 33
Z9 33
U1 2
U2 26
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 1946-6234
EI 1946-6242
J9 SCI TRANSL MED
JI Sci. Transl. Med.
PD NOV 19
PY 2014
VL 6
IS 263
AR 263ra160
DI 10.1126/scitranslmed.3009980
PG 12
WC Cell Biology; Medicine, Research & Experimental
SC Cell Biology; Research & Experimental Medicine
GA AT8CD
UT WOS:000345160500006
PM 25411473
ER
PT J
AU Talley, AK
Healy, SA
Finney, OC
Murphy, SC
Kublin, J
Salas, CJ
Lundebjerg, S
Gilbert, P
Van Voorhis, WC
Whisler, J
Wang, RB
Ockenhouse, CF
Heppner, DG
Kappe, SH
Duffy, PE
AF Talley, Angela K.
Healy, Sara A.
Finney, Olivia C.
Murphy, Sean C.
Kublin, James
Salas, Carola J.
Lundebjerg, Susan
Gilbert, Peter
Van Voorhis, Wesley C.
Whisler, John
Wang, Ruobing
Ockenhouse, Chris F.
Heppner, D. Gray
Kappe, Stefan H.
Duffy, Patrick E.
TI Safety and Comparability of Controlled Human Plasmodium falciparum
Infection by Mosquito Bite in Malaria-Naive Subjects at a New Facility
for Sporozoite Challenge
SO PLOS ONE
LA English
DT Article
ID TO-BLOOD INOCULA; HUMAN VOLUNTEERS; VACCINES; IMMUNITY; UPDATE; COHORT;
VIVAX; CELLS; MODEL; RATES
AB Background: Controlled human malaria infection (CHMI) studies which recapitulate mosquito-borne infection are a critical tool to identify protective vaccine and drug candidates for advancement to field trials. In partnership with the Walter Reed Army Institute of Research, the CHMI model was established at the Seattle Biomedical Research Institute's Malaria Clinical Trials Center (MCTC). Activities and reagents at both centers were aligned to ensure comparability and continued safety of the model. To demonstrate successful implementation, CHMI was performed in six healthy malaria-naive volunteers.
Methods: All volunteers received NF54 strain Plasmodium falciparum by the bite of five infected Anopheles stephensi mosquitoes under controlled conditions and were monitored for signs and symptoms of malaria and for parasitemia by peripheral blood smear. Subjects were treated upon diagnosis with chloroquine by directly observed therapy. Immunological (T cell and antibody) and molecular diagnostic (real-time quantitative reverse transcriptase polymerase chain reaction [qRT-PCR]) assessments were also performed.
Results: All six volunteers developed patent parasitemia and clinical malaria. No serious adverse events occurred during the study period or for six months post-infection. The mean prepatent period was 11.2 days (range 9-14 days), and geometric mean parasitemia upon diagnosis was 10.8 parasites/mu L (range 2-69) by microscopy. qRT-PCR detected parasites an average of 3.7 days (range 2-4 days) earlier than blood smears. All volunteers developed antibodies to the blood-stage antigen merozoite surface protein 1 (MSP-1), which persisted up to six months. Humoral and cellular responses to pre-erythrocytic antigens circumsporozoite protein (CSP) and liver-stage antigen 1 (LSA-1) were limited.
Conclusion: The CHMI model was safe, well tolerated and characterized by consistent prepatent periods, pre-symptomatic diagnosis in 3/6 subjects and adverse event profiles as reported at established centers. The MCTC can now evaluate candidates in the increasingly diverse vaccine and drug pipeline using the CHMI model.
C1 [Talley, Angela K.; Finney, Olivia C.; Lundebjerg, Susan; Whisler, John; Wang, Ruobing; Kappe, Stefan H.] Seattle Biomed Res Inst, Malaria Clin Trials Ctr, Seattle, WA 98109 USA.
[Healy, Sara A.; Duffy, Patrick E.] NIAID, Lab Malaria Immunol & Vaccinol, NIH, Bethesda, MD 20892 USA.
[Murphy, Sean C.] Univ Washington, Med Ctr, Dept Lab Med, Seattle, WA 98195 USA.
[Kublin, James; Gilbert, Peter] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA.
[Salas, Carola J.] US Naval Med Res Unit 6, Lima, Peru.
[Van Voorhis, Wesley C.] Univ Washington, Med Ctr, Dept Med, Seattle, WA 98195 USA.
[Ockenhouse, Chris F.; Heppner, D. Gray] Walter Reed Army Inst Res, US Mil Malaria Vaccine Program, Silver Spring, MD USA.
RP Duffy, PE (reprint author), NIAID, Lab Malaria Immunol & Vaccinol, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
EM patrick.duffy@nih.gov
FU PATH Malaria Vaccine Initiative (MVI); United States Department of
Defense; Intramural Research Program of National Institute of Allergy
and Infectious Diseases, National Institutes of Health; Global Emerging
Infections Surveillance and Response System of the United States
Department of Defense (AFHSC/GEIS) [847705.82000.256B.B0016]
FX Funding for the initial MCTC infrastructure and for this clinical trial
funding was provided by the PATH Malaria Vaccine Initiative (MVI) and
the United States Department of Defense. MVI staff (Florence Kaltovich
and Cynthia Lee) provided technical support on the chemistry,
manufacturing, and control section of the IND application and the
clinical operations aspects associated with this study, the latter
through MVI's clinical quality assurance consultants at The Total
Approach. C. F. O. is now employed by MVI/PATH and contributed to the
review of the manuscript. This work was also supported by the Intramural
Research Program of National Institute of Allergy and Infectious
Diseases, National Institutes of Health (S. A. H., P. E. D.), and the
Global Emerging Infections Surveillance and Response System of the
United States Department of Defense (AFHSC/GEIS) under work unit number
847705.82000.256B.B0016 (C. J. S.). The authors have no conflicts that
affect their adherence to all PLOS ONE policies on sharing data and
materials.
NR 27
TC 6
Z9 7
U1 0
U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD NOV 18
PY 2014
VL 9
IS 11
AR e109654
DI 10.1371/journal.pone.0109654
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AX7UZ
UT WOS:000347121300006
PM 25405724
ER
PT J
AU Baker, DR
Simmerman, RF
Sumner, JJ
Bruce, BD
Lundgren, CA
AF Baker, David R.
Simmerman, Richard F.
Sumner, James J.
Bruce, Barry D.
Lundgren, Cynthia A.
TI Photoelectrochemistry of Photosystem I Bound in Nafion
SO LANGMUIR
LA English
DT Article
ID AMPEROMETRIC GLUCOSE SENSORS; REDOX POLYMER-FILMS; ENZYME ELECTRODES;
REACTION CENTERS; OXIDASE; ELECTROCHEMISTRY; IMMOBILIZATION; PROTEINS;
CELLS; POLYPYRROLE
AB Developing a solid state Photosystem I (PSI) modified electrode is attractive for photoelectrochemical applications because of the quantum yield of PSI, which approaches unity in the visible spectrum. Electrodes are constructed using a Nafion film to encapsulate PSI as well as the hole-scavenging reox me PY diator Os(b) Cl The photoactive electrodes generate photo, currents of 4 mu A/cm2.+1,vhen illuminated with 1.4 mW/cm(2) of 676 nm band-pass' filtered light. Methyl viologen (MV4) is present in the electrolyte to scavenge photoelectrons from PSI in the Nafion film and transport charges to the counter electrode. Because MV2+ is positively charged in both reduced and oxidized states, it is able to diffuse through the cation permeable channels of Nafion. Photocurrent is produced when the working electrode is set to voltages negative of the 0s3+/Os2+ redox potential. Charge transfer through the Nafion film and photohole,scavenging at the PSI luminal surface by Os(bpy)(2) Cl-2 depends on the reduction of Os redox centers to Os2+ via hole scavenging from PSI. The optimal film densities of Nafion (10 pg/cm 2 Nafion) and PSI (100 trg/cm2 PSI), are determined to provide the highest photocurrents. These optimal film densities force films to be thin to allow the majority of PSI to have productive electrical contact with the backing electrode.
C1 [Baker, David R.; Sumner, James J.; Lundgren, Cynthia A.] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
[Simmerman, Richard F.; Bruce, Barry D.] Univ Tennessee, Dept Biochem & Cellular & Mol Biol, Knoxville, TN 37996 USA.
RP Lundgren, CA (reprint author), 2800 Powder Mill Rd Adelphi, Adelphi, MD 20783 USA.
EM cynthia.a.lundgren2.civ@mail.mil
FU U.S. Department of the Army; U.S. Army Materiel Command; U.S. Army
Research Laboratory Postdoctoral Fellowship Program administered by the
Oak Ridge Associated Universities; NSF-EPSCOR [EPS-1004083]; National
Science Foundation IGERT program [DGE0801470]; Directors Strategic
Initiative, "Understanding Photosystem I as a Biomolecular Reactor for
Energy Conversion" at the Army Research Laboratory, Ade lphi, MD, USA
[W911NF-11-2-0029]
FX Financial support from the U.S. Department of the Army and U.S. Army
Materiel Command are gratefully acknowledged.Research was supported, in
part, by a contractual appointment to the U.S. Army Research Laboratory
Postdoctoral Fellowship Program administered by the Oak Ridge Associated
Universities (D.RB.). B.D.B. acknowledges support from TNSCORE, a
multidisciplinary research program sponsored by NSF-EPSCOR
(EPS-1004083), and support from the Gibson Family Foundation. R.F.S. was
supported as an IGERT fellow from the National Science Foundation IGERT
program (DGE0801470). We also acknowledge support from the Directors
Strategic Initiative, "Understanding Photosystem I as a Biomolecular
Reactor for Energy Conversion" at the Army Research Laboratory, Ade
lphi, MD, USA (ARL Contract #W911NF-11-2-0029).
NR 45
TC 8
Z9 8
U1 6
U2 56
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0743-7463
J9 LANGMUIR
JI Langmuir
PD NOV 18
PY 2014
VL 30
IS 45
BP 13650
EP 13655
DI 10.1021/la503132h
PG 6
WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science,
Multidisciplinary
SC Chemistry; Materials Science
GA AT9RS
UT WOS:000345264500019
PM 25341002
ER
PT J
AU Massaro, E
Bagnoli, F
AF Massaro, Emanuele
Bagnoli, Franco
TI Epidemic spreading and risk perception in multiplex networks: A
self-organized percolation method
SO PHYSICAL REVIEW E
LA English
DT Article
ID INTERDEPENDENT NETWORKS; SOCIAL NETWORKS; EVOLUTION; WORLD
AB In this paper we study the interplay between epidemic spreading and risk perception on multiplex networks. The basic idea is that the effective infection probability is affected by the perception of the risk of being infected, which we assume to be related to the fraction of infected neighbors, as introduced by Bagnoli et al. [Phys. Rev. E 76, 061904 (2007)]. We rederive previous results using a self-organized method that automatically gives the percolation threshold in just one simulation. We then extend the model to multiplex networks considering that people get infected by physical contacts in real life but often gather information from an information network, which may be quite different from the physical ones. The similarity between the physical and the information networks determines the possibility of stopping the infection for a sufficiently high precaution level: if the networks are too different, there is no means of avoiding the epidemics.
C1 [Massaro, Emanuele] US Army Engineer Res & Dev Ctr, Risk & Decis Sci Team, Concord, MA 01742 USA.
[Massaro, Emanuele] Carnegie Mellon Univ, Dept Civil & Environm Engn, Pittsburgh, PA 15213 USA.
[Bagnoli, Franco] Univ Florence, Dipartimento Fis & Astron, I-50019 Florence, Italy.
[Bagnoli, Franco] Univ Florence, CSDC, I-50019 Florence, Italy.
[Bagnoli, Franco] Ist Nazl Fis Nucl, Sez Firenze, I-50019 Florence, Italy.
RP Massaro, E (reprint author), US Army Engineer Res & Dev Ctr, Risk & Decis Sci Team, 696 Virginia Rd, Concord, MA 01742 USA.
EM emassaro@andrew.cmu.edu; franco.bagnoli@unifi.it
RI Bagnoli, Franco/K-6904-2015
OI Bagnoli, Franco/0000-0002-6293-0305
FU European Commission [ICT-20111.1.6, 288021, FP7-ICT-2013-10, 611299
SciCafe 2.0]
FX The authors are grateful to Dr. Nicola Perra for helpful discussions. F.
B. acknowledges partial financial support from European Commission
(ICT-20111.1.6) Proposal No. 288021 EINS - Network of Excellence in
Internet Science and European Commission (FP7-ICT-2013-10) Proposal No.
611299 SciCafe 2.0.
NR 23
TC 17
Z9 19
U1 0
U2 19
PU AMER PHYSICAL SOC
PI COLLEGE PK
PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA
SN 2470-0045
EI 2470-0053
J9 PHYS REV E
JI Phys. Rev. E
PD NOV 18
PY 2014
VL 90
IS 5
AR 052817
DI 10.1103/PhysRevE.90.052817
PG 8
WC Physics, Fluids & Plasmas; Physics, Mathematical
SC Physics
GA AT9MN
UT WOS:000345251500009
ER
PT J
AU Turalska, M
West, BJ
AF Turalska, M.
West, B. J.
TI Imitation versus payoff: Duality of the decision-making process
demonstrates criticality and consensus formation
SO PHYSICAL REVIEW E
LA English
DT Article
ID EVOLUTIONARY GAMES; PRISONERS-DILEMMA; PROMOTE COOPERATION; BEHAVIOR
AB We consider a dual model of decision making, in which an individual forms its opinion based on contrasting mechanisms of imitation and rational calculation. The decision-making model (DMM) implements imitating behavior by means of a network of coupled two-state master equations that undergoes a phase transition at a critical value of a control parameter. The evolutionary spatial game, being a generalization of the prisoner's dilemma game, is used to determine in objective fashion the cooperative or anticooperative strategy adopted by individuals. Interactions between two sources of dynamics increases the domain of initial states attracted to phase transition dynamics beyond that of the DMM network in isolation. Additionally, on average the influence of the DMM on the game increases the final observed fraction of cooperators in the system.
C1 [Turalska, M.; West, B. J.] Duke Univ, Dept Phys, Durham, NC 27709 USA.
[West, B. J.] US Army Res Off, Informat Sci Directorate, Res Triangle Pk, NC 27708 USA.
RP Turalska, M (reprint author), Duke Univ, Dept Phys, Durham, NC 27709 USA.
FU Army Research Office [W911NF-04-D-0001]
FX The authors thank the Army Research Office for support of this research
(Grant No. W911NF-04-D-0001).
NR 35
TC 1
Z9 1
U1 0
U2 11
PU AMER PHYSICAL SOC
PI COLLEGE PK
PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA
SN 2470-0045
EI 2470-0053
J9 PHYS REV E
JI Phys. Rev. E
PD NOV 18
PY 2014
VL 90
IS 5
AR 052815
DI 10.1103/PhysRevE.90.052815
PG 7
WC Physics, Fluids & Plasmas; Physics, Mathematical
SC Physics
GA AT9MN
UT WOS:000345251500007
ER
PT J
AU McWilliams, B
Dibelka, J
Yen, CF
AF McWilliams, B.
Dibelka, J.
Yen, C. -F.
TI Multi scale modeling and characterization of inelastic deformation
mechanisms in continuous fiber and 2D woven fabric reinforced metal
matrix composites
SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES
MICROSTRUCTURE AND PROCESSING
LA English
DT Article
DE Metal matrix composites (MMCs); Mechanical properties; Finite element
method; Micromechanics; Cohesive zone modeling
ID TENSILE-STRENGTH; FLOW-STRESS; ALUMINUM; DAMAGE; BEHAVIOR; EVOLUTION;
FRACTURE; YIELD
AB Continuous unidirectional ceramic fiber and woven fabric reinforced metal matrix composites (MMCs) have potential to obtain very high specific strengths and stiffnesses, but use in structural applications has thus far been limited by their inherently low ductility, particularly in tensile loading conditions. In this work, a multi-scale micromechanics based finite element framework is used to predict, and understand the effect of microstructure on the tensile deformation behavior, including progressive damage and failure, of ceramic fiber and fabric reinforced MMCs. A hierarchal approach is implemented in which a micro-scale model is used to determine the transversely isotropic elasto-plastic mechanical behavior of unidirectional fiber reinforced MMC based on the properties of an aluminum alloy matrix, individual ceramic fibers, and the fiber-matrix interface. The validated transversely isotropic constitutive behavior is then input into a unit cell model for a woven fabric MMC consisting of unidirectional MMC tows in an aluminum matrix. Parallel experimental tensile testing and characterization of fracture mechanisms are used to validate our model for unidirectional and 2D weave fabric MMC. Cohesive zones are used to model the interfacial properties at both scales and we are able to quantify the contribution of various deformation and damage mechanisms such as ductile matrix failure, interfacial decohesion, transverse plasticity, and axial fiber fracture to the overall mechanical response of the MMC. It was found that interfacial debonding contributes significantly to the inelastic response of unidirectional and woven fabric MMC and that experimental data are relatively well reproduced by a model that assumes a weak interfacial debonding cohesive law (maximum allowable interface stresses on the order of 100 MPa and total work of decohesion = 75 J/m(2)). Published by Elsevier B.V.
C1 [McWilliams, B.; Yen, C. -F.] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
[Dibelka, J.] Naval Surface Warfare Ctr, Carderock Div, West Bethesda, MD USA.
RP McWilliams, B (reprint author), US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
EM brandon.a.mcwilliams.civ@mail.mil; jessica.a.dibelka.civ@mail.mil;
chianfong.yen.civ@mail.mil
NR 48
TC 3
Z9 3
U1 3
U2 24
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0921-5093
EI 1873-4936
J9 MAT SCI ENG A-STRUCT
JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process.
PD NOV 17
PY 2014
VL 618
BP 142
EP 152
DI 10.1016/j.msea.2014.08.063
PG 11
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary;
Metallurgy & Metallurgical Engineering
SC Science & Technology - Other Topics; Materials Science; Metallurgy &
Metallurgical Engineering
GA AS7MG
UT WOS:000344439500018
ER
PT J
AU Adlakha, I
Tschopp, MA
Solanki, KN
AF Adlakha, I.
Tschopp, M. A.
Solanki, K. N.
TI The role of grain boundary structure and crystal orientation on crack
growth asymmetry in aluminum
SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES
MICROSTRUCTURE AND PROCESSING
LA English
DT Article
DE Grain boundary; Twinning; Dislocation; Fracture; Directional anisotropy
ID MOLECULAR-DYNAMICS SIMULATION; SYMMETRICAL TILT BOUNDARIES; CSL TWIST
BOUNDARIES; DISLOCATION NUCLEATION; FCC METALS; DIRECTIONAL DEPENDENCE;
COMPUTER-SIMULATION; COPPER/SAPPHIRE BICRYSTAL; NANOCRYSTALLINE
MATERIALS; DEFORMATION-MECHANISM
AB Atomistic simulations have shown that the grain boundary (GB) structure affects a number of physical, mechanical, thermal, and chemical properties, which can have a profound effect on macroscopic properties of polycrystalline materials. The research objective herein is to use atomistic simulations to explore the role that GB structure and the adjacent crystallographic orientations have on the directional asymmetry of an intergranular crack (i.e. cleavage behavior is favored along one direction, while ductile behavior along the other direction of the interface) for aluminum grain boundaries. Simulation results from seven [110] symmetric tilt grain boundaries (STGBs) show that the GB structure and the associated free volume directly influence the stress-strain response, crack growth rate, and crack tip plasticity mechanisms for middle-tension (M(T)) crack propagation specimens. In particular, the structural units present within the GB promote whether a dislocation or twinning-based mechanism operates at the crack tip during intergranular fracture along certain GBs (e.g., the 'E' structural unit promotes twinning at the crack tip in Al). Furthermore, the crystallography of the adjacent grains, and therefore the available slip planes, can significantly affect the crack growth rates in both directions of the crack - this creates a strong directional asymmetry in the crack growth rate in the Sigma 11 (113) and the Sigma 27 (552) STGBs. Upon comparing these results with the theoretical Rice criterion, it was found that certain GBs in this study (Sigma 9 (221), Sigma 11 (332) and Sigma 33 (441)) show an absence of directional asymmetry in the observed crack growth behavior, in conflict with the Rice criterion. The significance of the present research is that it provides a physical basis for the role of GB character and crystallographic orientation on intergranular crack tip deformation behavior. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Adlakha, I.; Solanki, K. N.] Arizona State Univ, Sch Engn Matter Transport & Energy, Tempe, AZ 85287 USA.
[Tschopp, M. A.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Solanki, KN (reprint author), Arizona State Univ, Sch Engn Matter Transport & Energy, Tempe, AZ 85287 USA.
EM kiran.solanki@asu.edu
RI Solanki, Kiran/E-8337-2010;
OI Adlakha, Ilaksh/0000-0002-2028-3357; Tschopp, Mark/0000-0001-8471-5035
FU Office of Naval Research [N000141110793]
FX The authors would like to recognize Dr. W. Mullins and Dr. A.K.
Vasudevan from the Office of Naval Research for providing insights and
valuable suggestions. This material is based upon work supported by the
Office of Naval Research under contract no. N000141110793. We would also
like to acknowledge the Fulton High Performance Computing at Arizona
State University.
NR 78
TC 7
Z9 7
U1 5
U2 56
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0921-5093
EI 1873-4936
J9 MAT SCI ENG A-STRUCT
JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process.
PD NOV 17
PY 2014
VL 618
BP 345
EP 354
DI 10.1016/j.msea.2014.08.083
PG 10
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary;
Metallurgy & Metallurgical Engineering
SC Science & Technology - Other Topics; Materials Science; Metallurgy &
Metallurgical Engineering
GA AS7MG
UT WOS:000344439500041
ER
PT J
AU Williams, CL
Chen, CQ
Ramesh, KT
Dandekar, DP
AF Williams, C. L.
Chen, C. Q.
Ramesh, K. T.
Dandekar, D. P.
TI On the shock stress, substructure evolution, and spall response of
commercially pure 1100-O aluminum
SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES
MICROSTRUCTURE AND PROCESSING
LA English
DT Article
DE Shock stress; Shock hardening; Dynamic recovery; Substructure;
Evolution; Recovery
ID STRAIN RATE DEFORMATION; STAINLESS-STEEL; GRAIN-SIZE; MICROSTRUCTURES;
BEHAVIOR; FAILURE; METALS; COPPER; NICKEL
AB Plate impact shock and spall recovery experiments were conducted to study the effects of peak shock stress on the substructure evolution and spall response of fully annealed 1100 aluminum. The substructure of the material evolves substantially with increase in peak shock stress ranging from 4 GPa to 9 GPa with dislocation debris uniformly distributed throughout the interior of the subgrain. Observations from substructure evolution in conjunction with spall failure results suggest that ductile fracture by void nucleation, growth, and coalescence was perhaps the dominant fracture mode for shock stresses up to approximately 8.3 GPa. Whereas, beyond 8.3 GPa the material softened possibly due to dislocation reorganization (dynamic recovery) and brittle intergranular fracture by decohesion with isolated pockets of nanovoids was perhaps the dominant fracture mode. The contributions of nanovoids to the dynamic recovery process, if any, were unresolved. Microhardness measurements show an increase in residual hardness throughout the shock stress range studied implying shock hardening up to approximately 8.3 GPa. This observation also suggests that thermal softening was not operative throughout the shock stress range studied. However, dynamic recovery was thermally influenced during shock loading. Published by Elsevier B.V.
C1 [Williams, C. L.; Dandekar, D. P.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Chen, C. Q.; Ramesh, K. T.] Johns Hopkins Univ, Baltimore, MD 21218 USA.
RP Williams, CL (reprint author), US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM cyril.l.williams.civ@mail.mil
FU United States Army Research Laboratory (ARL) at Aberdeen Proving Ground;
Center for Advanced Metallic and Ceramic Systems (CAMCS) at The Johns
Hopkins University under ARMAC-RTP [W911NF-06-2-0006]
FX Funding for this research was provided by both the United States Army
Research Laboratory (ARL) at Aberdeen Proving Ground and the Center for
Advanced Metallic and Ceramic Systems (CAMCS) at The Johns Hopkins
University under ARMAC-RTP Cooperative Agreement no. W911NF-06-2-0006.
The authors wish to acknowledge Dr. George ''Rusty'' Gray III (Los
Alamos National Laboratory) for his valuable technical suggestions with
regards to the recovery experiments and Dr. John D. Clayton for
reviewing the manuscript
NR 55
TC 1
Z9 1
U1 2
U2 15
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0921-5093
EI 1873-4936
J9 MAT SCI ENG A-STRUCT
JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process.
PD NOV 17
PY 2014
VL 618
BP 596
EP 604
DI 10.1016/j.msea.2014.09.030
PG 9
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary;
Metallurgy & Metallurgical Engineering
SC Science & Technology - Other Topics; Materials Science; Metallurgy &
Metallurgical Engineering
GA AS7MG
UT WOS:000344439500073
ER
PT J
AU Garg, K
Corona, BT
Walters, TJ
AF Garg, Koyal
Corona, Benjamin T.
Walters, Thomas J.
TI Losartan administration reduces fibrosis but hinders functional recovery
after volumetric muscle loss injury
SO JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Article
DE losartan; fibrosis; volumetric muscle loss; regeneration
ID SPONTANEOUSLY HYPERTENSIVE-RATS; REVERSES MYOCARDIAL FIBROSIS;
GROWTH-FACTOR-BETA; COLLAGEN TYPE-I; SKELETAL-MUSCLE; ANGIOTENSIN-II;
TGF-BETA; INFLAMMATORY RESPONSE; MOLECULAR-MECHANISMS; ANTIFIBROSIS
AGENT
AB Losartan is a Food and Drug Administration approved antihypertensive medication that is recently emerging as an antifibrotic therapy. Previously, losartan has been successfully used to reduce fibrosis and improve both muscle regeneration and function in several models of recoverable skeletal muscle injuries, such as contusion and laceration. In this study, the efficacy of losartan treatment in reducing fibrosis and improving regeneration was determined in a Lewis rat model of volumetric muscle loss (VML) injury. VML has been defined as the traumatic or surgical loss of skeletal muscle with resultant functional impairment. It is among the top 10 causes for wounded service members to be medically retired from the military. This study shows that, after several weeks of recovery, VML injury results in little to no muscle regeneration, but is marked by persistent inflammation, chronic upregulation of profibrotic markers and extracellular matrix (i.e., collagen type I), and fat deposition at the defect site, which manifest irrecoverable deficits in force production. Losartan administration at 10 mg.kg(-1).day(-1) was able to modulate the gene expression of fibrotic markers and was also effective at reducing fibrosis (i.e., the deposition of collagen type I) in the injured muscle. However, there were no improvements in muscle regeneration, and deleterious effects on muscle function were observed instead. We propose that, in the absence of regeneration, reduction in fibrosis worsens the ability of the VML injured muscle to transmit forces, which ultimately results in decreased muscle function.
C1 [Garg, Koyal; Corona, Benjamin T.; Walters, Thomas J.] US Army, Inst Surg Res Extrem Trauma & Regenerat Med, Ft Sam Houston, TX 78234 USA.
RP Walters, TJ (reprint author), US Army, Inst Surg Res Extrem Trauma & Regenerat Med, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.
EM thomas.j.walters22.civ@mail.mil
FU Combat Casualty Care Research Program, Medical Research and Materiel
Command
FX These studies were funded by the Combat Casualty Care Research Program,
Medical Research and Materiel Command.
NR 57
TC 6
Z9 6
U1 2
U2 5
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 8750-7587
EI 1522-1601
J9 J APPL PHYSIOL
JI J. Appl. Physiol.
PD NOV 15
PY 2014
VL 117
IS 10
BP 1120
EP 1131
DI 10.1152/japplphysiol.00689.2014
PG 12
WC Physiology; Sport Sciences
SC Physiology; Sport Sciences
GA AT9MW
UT WOS:000345252300006
PM 25257876
ER
PT J
AU Koster, R
Mitra, N
D'Andrea, K
Vardhanabhuti, S
Chung, CC
Wang, ZM
Erickson, RL
Vaughn, DJ
Litchfield, K
Rahman, N
Greene, MH
McGlynn, KA
Turnbull, C
Chanock, SJ
Nathanson, KL
Kanetsky, PA
AF Koster, Roelof
Mitra, Nandita
D'Andrea, Kurt
Vardhanabhuti, Saran
Chung, Charles C.
Wang, Zhaoming
Erickson, R. Loren
Vaughn, David J.
Litchfield, Kevin
Rahman, Nazneen
Greene, Mark H.
McGlynn, Katherine A.
Turnbull, Clare
Chanock, Stephen J.
Nathanson, Katherine L.
Kanetsky, Peter A.
TI Pathway-based analysis of GWAs data identifies association of sex
determination genes with susceptibility to testicular germ cell tumors
SO HUMAN MOLECULAR GENETICS
LA English
DT Article
ID GENOME-WIDE ASSOCIATION; CARCINOMA IN-SITU; TRANSCRIPTION FACTOR GATA-4;
TESTIS DIFFERENTIATION; EXPRESSION PROFILES; ENRICHMENT ANALYSIS;
MAMMALIAN TESTIS; DMRT1; CANCER; VARIANTS
AB Genome-wide association (GWA) studies of testicular germ cell tumor (TGCT) have identified 18 susceptibility loci, some containing genes encoding proteins important in male germ cell development. Deletions of one of these genes, DMRT1, lead to male-to-female sex reversal and are associated with development of gonadoblastoma. To further explore genetic association with TGCT, we undertook a pathway-based analysis of SNP marker associations in the Penn GWAs (349 TGCT cases and 919 controls). We analyzed a custom-built sex determination gene set consisting of 32 genes using three different methods of pathway-based analysis. The sex determination gene set ranked highly compared with canonical gene sets, and it was associated with TGCT (FDRG(5) = 2.28 x 10(-5), FDRM = 0.014 and FDRI = 0.008 for Gene Set Analysis-SNP (GSA-SNP), Meta-Analysis Gene Set Enrichment of Variant Associations (MAGENTA) and Improved Gene Set Enrichment Analysis for Genomewide Association Study (i-GSEA4GWAS) analysis, respectively). The association remained after removal of DMRT1 from the gene set (FDRG = 0.0002, FDRM = 0.055 and FDRI = 0.009). Using data from the NCI GWA scan (582 TGCT cases and 1056 controls) and UK scan (986 TGCT cases and 4946 controls), we replicated these findings (NCI: FDRG = 0.006, FDRM = 0.014, FDRI = 0.033, and UK: FDRG = 1.04 x 10(-6), FDRM = 0.016, FDRI = 0.025). After removal of DMRT1 from the gene set, the sex determination gene set remains associated ith TGCT in the NCI (FDRG = 0.039, FDRM = 0.050 and FDRI = 0.055) and UK scans (FDRG = 3.00 x 10(-5), FDRM = 0.056 and FDRI = 0.044). With the exception of DMRT1, genes in the sex determination gene set have not previously been identified as TGCT susceptibility loci in these GWA scans, demonstrating the complementary nature of a pathway-based approach for genome-wide analysis of TGCT.
C1 [Koster, Roelof; D'Andrea, Kurt; Nathanson, Katherine L.] Univ Penn, Perelman Sch Med, Dept Med, Philadelphia, PA 19104 USA.
[Mitra, Nandita; Vardhanabhuti, Saran; Kanetsky, Peter A.] Univ Penn, Perelman Sch Med, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA.
[Vaughn, David J.] Univ Penn, Perelman Sch Med, Dept Med, Div Hematol Oncol, Philadelphia, PA 19104 USA.
[Vaughn, David J.; Nathanson, Katherine L.; Kanetsky, Peter A.] Univ Penn, Perelman Sch Med, Abramson Canc Ctr, Philadelphia, PA 19104 USA.
[Chung, Charles C.; Wang, Zhaoming; Greene, Mark H.; McGlynn, Katherine A.; Chanock, Stephen J.] NCI, Div Canc Epidemiol & Genet, Dept Hlth & Human Serv, NIH, Bethesda, MD 20892 USA.
[Wang, Zhaoming] NCI, Canc Genome Res Lab, Div Canc Epidemiol & Genet, SAIC Frederick Inc, Frederick, MD 21701 USA.
[Erickson, R. Loren] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Litchfield, Kevin; Rahman, Nazneen; Turnbull, Clare] Inst Canc Res, Div Genet & Epidemiol, Sutton, Surrey, England.
RP Kanetsky, PA (reprint author), H Lee Moffitt Canc Ctr & Res Inst, 12902 Magnolia Dr, Tampa, FL 33612 USA.
EM peter.kanetsky@moffitt.org
RI Koster, Roelof/E-2158-2016; Rahman, Nazneen/D-2802-2013
OI Koster, Roelof/0000-0003-1424-8579; Litchfield,
Kevin/0000-0002-3725-0914; Rahman, Nazneen/0000-0003-4376-0440
FU Abramson Cancer Center at the University of Pennsylvania; US National
Institutes of Health [R01CA114478]; NCI; Westat, Inc.
[HHSN261200655004C]; Institute of Cancer Research, Cancer Research UK;
Wellcome Trust
FX The Penn GWAS (PENN) was supported by the Abramson Cancer Center at the
University of Pennsylvania and US National Institutes of Health grant
R01CA114478 to P. A. K. and K.L.N. The NCIGWAS work was supported by the
Intramural Research Program of the NCI and by support services contract
HHSN261200655004C with Westat, Inc. The UK testicular cancer study was
supported by the Institute of Cancer Research, Cancer Research UK and
the Wellcome Trust and made use of control data generated by the
Wellcome Trust Case Control Consortium 2 (WTCCC2).
NR 75
TC 11
Z9 12
U1 1
U2 11
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0964-6906
EI 1460-2083
J9 HUM MOL GENET
JI Hum. Mol. Genet.
PD NOV 15
PY 2014
VL 23
IS 22
BP 6061
EP 6068
DI 10.1093/hmg/ddu305
PG 8
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA AT1CY
UT WOS:000344671900018
PM 24943593
ER
PT J
AU Sarney, WL
Svensson, SP
Anderson, EM
Lundquist, AM
Pearson, C
Millunchick, JM
AF Sarney, W. L.
Svensson, S. P.
Anderson, E. M.
Lundquist, A. M.
Pearson, C.
Millunchick, J. M.
TI The influence of growth temperature on Sb incorporation in InAsSb, and
the temperature-dependent impact of Bi surfactants
SO JOURNAL OF CRYSTAL GROWTH
LA English
DT Article
DE Molecular beam epitaxy; Semiconducting III-V materials
ID MOLECULAR-BEAM EPITAXY; BISMUTH; INSB; GAAS
AB A series of two layer InAsSb films were grown with molecular beam epitaxy (MBE). We report the effect of substrate temperature on the composition of InAsSb grown with and without a Bi surfactant and find that the Sb incorporation is suppressed as the substrate temperature increases, and that it is also further suppressed by the presence of Bi at all temperatures. We examine the data with a kinetic model, which gives insights into the composition of mixed anion alloys using straightforward rate equations for each process that occurs during growth. It was shown that the reduction in Sb composition is due to the preferential removal of Bi by As, and that removal rate obeys an Arrhenius dependence with an activation energy of 1.35 eV. Published by Elsevier B.V.
C1 [Sarney, W. L.; Svensson, S. P.] US Army, Res Lab, Adelphi, MD 20783 USA.
[Anderson, E. M.; Lundquist, A. M.; Millunchick, J. M.] Univ Michigan, Dept Mat Sci & Engn, Ann Arbor, MI 48109 USA.
[Pearson, C.] Univ Michigan, Dept Comp Sci Engn & Phys, Flint, MI 48502 USA.
RP Sarney, WL (reprint author), US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM wendy.l.sarney.civ@mail.mil
FU Department of Defense, Army Research Office [W911NF-12-1-0338]
FX EMA, AML, CP, and JMM gratefully acknowledge Chakrapani Varanasi and the
support of the Department of Defense, Army Research Office via the Grant
number W911NF-12-1-0338.
NR 15
TC 1
Z9 1
U1 4
U2 24
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-0248
EI 1873-5002
J9 J CRYST GROWTH
JI J. Cryst. Growth
PD NOV 15
PY 2014
VL 406
BP 8
EP 11
DI 10.1016/j.jcrysgro.2014.07.048
PG 4
WC Crystallography; Materials Science, Multidisciplinary; Physics, Applied
SC Crystallography; Materials Science; Physics
GA AQ8QC
UT WOS:000343092800002
ER
PT J
AU Pike, AW
Zuo, QH
AF Pike, A. W.
Zuo, Q. H.
TI Geometric design consideration for controlled fragmentation of metallic
shells
SO FINITE ELEMENTS IN ANALYSIS AND DESIGN
LA English
DT Article
DE Controlled fragmentation; Natural fragmentation; CTH simulations;
Geometric consideration; Johnson-Cook failure model; Explosive loading
ID PHYSICS
AB Geometric designs for the controlled fragmentation of metal cylindrical shells have been considered via CTH hydrocode simulations. Fragmentation is controlled by engineering notches on the interior of the shells. Design parameters considered include the shell radius, thickness, and the depth and spacing of interior notches. A large number of shell designs were analyzed and their effectiveness on the controlled fragmentation categorized. The best overall controlled fragmentation designs exhibit full and complete fragment breakup as prescribed along the system of interior notches without any of the individual fragments naturally fragmenting throughout their thicknesses. For the combination of the Composition C-4 explosive and the 4340 steel, the best performing designs were shown to commonly possess the Following characteristics: (1) they each have notch or groove depths greater than half of the shell thickness. (2) they each have notch or groove spacing within a range that is approximately the same as the shell thickness, and (3) they each have shell thicknesses many times smaller than the shell radius. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Pike, A. W.; Zuo, Q. H.] Univ Alabama, Dept Mech & Aerosp Engn, Huntsville, AL 35899 USA.
[Pike, A. W.] US Army, AMRDEC, Redstone Arsenal, AL 35898 USA.
RP Zuo, QH (reprint author), Univ Alabama, Dept Mech & Aerosp Engn, Huntsville, AL 35899 USA.
EM zuo@eng.uah.edu
FU US Army's Aviation and Missile Research, Development, and Engineering
Center (AMRDEC); University of Alabama in Huntsville
FX The authors would like to thank J. Gilbert, A. Kissell, B, J. Smith, G.
Tackett, and D. Wallace for their guidance and support. the work was
supported in part by the US Army's Aviation and Missile Research,
Development, and Engineering Center (AMRDEC) and a research startup fund
from the University of Alabama in Huntsville. The authors are grateful
to two reviewers for their comments and suggestions which resulted in a
number of improvements of the manuscript.
NR 18
TC 2
Z9 3
U1 0
U2 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0168-874X
EI 1872-6925
J9 FINITE ELEM ANAL DES
JI Finite Elem. Anal. Des.
PD NOV 15
PY 2014
VL 91
BP 59
EP 67
DI 10.1016/j.finel.2014.07.012
PG 9
WC Mathematics, Applied; Mechanics
SC Mathematics; Mechanics
GA AO4KW
UT WOS:000341307800006
ER
PT J
AU Song, HS
Reifman, J
Wallqvist, A
AF Song, Hyun-Seob
Reifman, Jaques
Wallqvist, Anders
TI Prediction of Metabolic Flux Distribution from Gene Expression Data
Based on the Flux Minimization Principle
SO PLOS ONE
LA English
DT Article
ID ESCHERICHIA-COLI; SACCHAROMYCES-CEREVISIAE; BALANCE ANALYSIS; SYSTEMS
BIOLOGY; HIGH-THROUGHPUT; DRUG TARGETS; MODELS; NETWORKS;
RECONSTRUCTIONS; BIOMARKERS
AB Prediction of possible flux distributions in a metabolic network provides detailed phenotypic information that links metabolism to cellular physiology. To estimate metabolic steady-state fluxes, the most common approach is to solve a set of macroscopic mass balance equations subjected to stoichiometric constraints while attempting to optimize an assumed optimal objective function. This assumption is justifiable in specific cases but may be invalid when tested across different conditions, cell populations, or other organisms. With an aim to providing a more consistent and reliable prediction of flux distributions over a wide range of conditions, in this article we propose a framework that uses the flux minimization principle to predict active metabolic pathways from mRNA expression data. The proposed algorithm minimizes a weighted sum of flux magnitudes, while biomass production can be bounded to fit an ample range from very low to very high values according to the analyzed context. We have formulated the flux weights as a function of the corresponding enzyme reaction's gene expression value, enabling the creation of context-specific fluxes based on a generic metabolic network. In case studies of wild-type Saccharomyces cerevisiae, and wild-type and mutant Escherichia coli strains, our method achieved high prediction accuracy, as gauged by correlation coefficients and sums of squared error, with respect to the experimentally measured values. In contrast to other approaches, our method was able to provide quantitative predictions for both model organisms under a variety of conditions. Our approach requires no prior knowledge or assumption of a context-specific metabolic functionality and does not require trial-and-error parameter adjustments. Thus, our framework is of general applicability for modeling the transcription-dependent metabolism of bacteria and yeasts.
C1 [Song, Hyun-Seob; Reifman, Jaques; Wallqvist, Anders] US Army Med Res & Mat Command, Dept Def, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA.
RP Wallqvist, A (reprint author), US Army Med Res & Mat Command, Dept Def, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA.
EM awallqvist@bhsai.org
OI wallqvist, anders/0000-0002-9775-7469
FU U.S. Army Network Science Initiative
FX This work was funded as part of the U.S. Army Network Science
Initiative. The funders had no role in study design, data collection and
analysis, decision to publish, or preparation of the manuscript.
NR 41
TC 5
Z9 5
U1 1
U2 12
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD NOV 14
PY 2014
VL 9
IS 11
AR e112524
DI 10.1371/journal.pone.0112524
PG 11
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AU4DF
UT WOS:000345558500057
PM 25397773
ER
PT J
AU Sliozberg, Y
Chantawansri, T
AF Sliozberg, Yelena
Chantawansri, Tanya
TI Damage in spherical cellular membrane generated by the shock waves:
Coarse-grained molecular dynamics simulation of lipid vesicle
SO JOURNAL OF CHEMICAL PHYSICS
LA English
DT Article
ID DISSIPATIVE PARTICLE DYNAMICS; TRAUMATIC BRAIN-INJURY; MESOSCOPIC
SIMULATION; NEURONAL INJURY; IN-VITRO; PRESSURE; BILAYERS; PERMEABILITY;
LITHOTRIPSY; MORPHOLOGY
AB Traumatic Brain Injury is a major health issue that is hard to diagnose since it often occurs without signs of external injuries. While it is well known that exposure of biological cells to shock waves causes damage to the cell membrane, it is currently unknown by which mechanisms damage is caused, and how it depends on physical parameters such as shock wave velocity, shock pulse duration, or shock pulse shape. In this computational study, we use a coarse-grained model of the lipid vesicle as a generic model of a cell membrane to elucidate the general principles of the cellular damage induced by the shock wave direct passage through the cranium. Results indicate that the extent of the liposome compression does not strongly depend on the pressure pulse and that liposome extension is very sensitive to the change in the negative pressure phase. The structural integrity of the vesicle is altered as pores form in the lipid membrane at overall pressure impulses generated by supersonic shock waves, which are greater than 5 Pa . s at single or repetitive exposure. Consequently, these permeability changes may lead to changes in the influx of sodium, potassium, and calcium ions. (C) 2014 AIP Publishing LLC.
C1 [Sliozberg, Yelena] US Army Res Lab, TKC Global, Aberdeen Proving Ground, MD 21005 USA.
[Chantawansri, Tanya] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Sliozberg, Y (reprint author), US Army Res Lab, TKC Global, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA.
FU U.S. Army Research Laboratory [W911QX-14-C-0016]
FX The research reported in this document was performed in connection with
contract/instrument W911QX-14-C-0016 with the U.S. Army Research
Laboratory.
NR 53
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U1 3
U2 18
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0021-9606
EI 1089-7690
J9 J CHEM PHYS
JI J. Chem. Phys.
PD NOV 14
PY 2014
VL 141
IS 18
AR 184904
DI 10.1063/1.4901130
PG 10
WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical
SC Chemistry; Physics
GA AT3PZ
UT WOS:000344847600038
PM 25399159
ER
PT J
AU Arnold, BR
Roberson, SD
Pellegrino, PM
AF Arnold, Bradley R.
Roberson, Stephen D.
Pellegrino, Paul M.
TI Repopulation of Nitrogen Excited Triplet State Following Laser-Induced
Filamentation
SO JOURNAL OF PHYSICAL CHEMISTRY A
LA English
DT Article
ID ELECTRIC-FIELD STRENGTH; EMISSION-SPECTROSCOPY; ATMOSPHERIC-PRESSURE;
INTENSITY RATIO; SPECTRAL BANDS; MOLECULAR NITROGEN; RADIATIVE LIFETIME;
METASTABLE STATES; IMPACT EXCITATION; C3PIU STATE
AB Laser-induced filamentation was used to study the dynamics of excited molecular nitrogen decay processes. It is well-known that upper excited nitrogen triplet states can be repopulated at time delays far longer than their fluorescence lifetimes. Examination of the time-resolved emission from several different species indicates that there are two major mechanisms acting to repopulate the N-2((CIIu)-I-3) excited state. The results implicate dissociative electron recombination with the nitrogen cation dimer, N-4(+), and energy pooling between two N-2(A(u)(3 Sigma)(+)) triplet states as the main pathways to repopulate the emissive upper triplet state. The densities of N-2(A(3)Sigma(+)(u)) and free electrons produced during filamentation were measured under atmospheric pressures in nitrogen and estimated to be [N-2(A(3)Sigma(+)(u))](0) = 3 X 10(15) cm(-3) and [e](0) = 3 X 10(13) cm(-3). The methods outlined in this report could find significant utility in measuring the concentration profiles of these important reactive intermediates within laser-induced filaments produced under different conditions.
C1 [Arnold, Bradley R.; Roberson, Stephen D.; Pellegrino, Paul M.] US Army Res Lab, RDRL SEE O, Adelphi, MD 20783 USA.
[Arnold, Bradley R.] Univ Maryland Baltimore Cty, Dept Chem & Biochem, Baltimore, MD 21250 USA.
RP Arnold, BR (reprint author), US Army Res Lab, RDRL SEE O, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM barnold@umbc.edu
FU MPCA; RDECOM-ARL: Army Research Laboratory under U.S. Army Research
Office Scientific Services Program [0979, W911NF-07-D-0001]; Department
of Chemistry and Biochemistry at UMBC
FX The authors wish to acknowledge the MPCA for partial support of this
research. BRA further acknowledges support by the RDECOM-ARL: Army
Research Laboratory under the auspices of the U.S. Army Research Office
Scientific Services Program administered by Battelle (Delivery Order
0979, Contract No. W911NF-07-D-0001) and the Department of Chemistry and
Biochemistry at UMBC.
NR 53
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Z9 0
U1 2
U2 17
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1089-5639
J9 J PHYS CHEM A
JI J. Phys. Chem. A
PD NOV 13
PY 2014
VL 118
IS 45
BP 10456
EP 10463
DI 10.1021/jp504237p
PG 8
WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical
SC Chemistry; Physics
GA AT5IK
UT WOS:000344976900020
PM 24991979
ER
PT J
AU Lakhashe, SK
Byrareddy, SN
Zhou, MK
Bachler, BC
Hemashettar, G
Hu, SL
Villinger, F
Else, JG
Stock, S
Lee, SJ
Vargas-Inchaustegui, DA
Cofano, EB
Robert-Guroff, M
Johnson, WE
Polonis, VR
Forthal, DN
Loret, EP
Rasmussen, RA
Ruprecht, RM
AF Lakhashe, Samir K.
Byrareddy, Siddappa N.
Zhou, Mingkui
Bachler, Barbara C.
Hemashettar, Girish
Hu, Shiu-Lok
Villinger, Francois
Else, James G.
Stock, Shannon
Lee, Sandra J.
Vargas-Inchaustegui, Diego A.
Cofano, Egidio Brocca
Robert-Guroff, Marjorie
Johnson, Welkin E.
Polonis, Victoria R.
Forthal, Donald N.
Loret, Erwann P.
Rasmussen, Robert A.
Ruprecht, Ruth M.
TI Multimodality vaccination against clade C SHIV: Partial protection
against mucosal challenges with a heterologous tier 2 virus
SO VACCINE
LA English
DT Article
DE HIV vaccine; SHIV-C; Heterologous tier 2 virus; Rhesus monkey; Cellular
immunity; ADCC
ID SIMIAN IMMUNODEFICIENCY VIRUS; OVERLAPPING SYNTHETIC PEPTIDES; HIGHLY
PATHOGENIC SIV; RHESUS MACAQUES; NEUTRALIZING ANTIBODIES;
REPLICATION-COMPETENT; MOLECULAR CLONES; HIV-1 INFECTION; TAT VARIANTS;
EFFICACY
AB We sought to test whether vaccine-induced immune responses could protect rhesus macaques (RMs) against upfront heterologous challenges with an R5 simian-human immunodeficiency virus, SHIV-2873Nip. This SHIV strain exhibits many properties of transmitted HIV-1, such as tier 2 phenotype (relatively difficult to neutralize), exclusive CCR5 tropism, and gradual disease progression in infected RMs. Since no human AIDS vaccine recipient is likely to encounter an HIV-1 strain that exactly matches the immunogens, we immunized the RMs with recombinant Env proteins heterologous to the challenge virus. For induction of immune responses against Gag, Tat, and Nef, we explored a strategy of immunization with overlapping synthetic peptides (OSP). The immune responses against Gag and Tat were finally boosted with recombinant proteins. The vaccinees and a group of ten control animals were given five low-dose intrarectal (i.r.) challenges with SHIV-2873 Nip. All controls and seven out of eight vaccinees became systemically infected; there was no significant difference in viremia levels of vaccinees vs. controls. Prevention of viremia was observed in one vaccinee which showed strong boosting of virus-specific cellular immunity during virus exposures. The protected animal showed no challenge virus-specific neutralizing antibodies in the TZM-bl or A3R5 cell-based assays and had low-level ADCC activity after the virus exposures. Microarray data strongly supported a role for cellular immunity in the protected animal. Our study represents a case of protection against heterologous tier 2 SHIV-C by vaccine-induced, virus-specific cellular immune responses. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Lakhashe, Samir K.; Zhou, Mingkui; Ruprecht, Ruth M.] Texas Biomed Res Inst, San Antonio, TX 78245 USA.
[Ruprecht, Ruth M.] Southwest Natl Primate Res Ctr, San Antonio, TX USA.
[Lakhashe, Samir K.; Byrareddy, Siddappa N.; Zhou, Mingkui; Bachler, Barbara C.; Hemashettar, Girish; Stock, Shannon; Lee, Sandra J.; Rasmussen, Robert A.; Ruprecht, Ruth M.] Dana Farber Canc Inst, Boston, MA 02115 USA.
[Lakhashe, Samir K.; Byrareddy, Siddappa N.; Zhou, Mingkui; Lee, Sandra J.; Rasmussen, Robert A.; Ruprecht, Ruth M.] Harvard Univ, Sch Med, Boston, MA USA.
[Hu, Shiu-Lok] Univ Washington, Seattle, WA 98195 USA.
[Byrareddy, Siddappa N.; Villinger, Francois; Else, James G.] Emory Univ, Sch Med, Dept Pathol & Lab Med, Atlanta, GA 30322 USA.
[Villinger, Francois; Else, James G.] Emory Univ, Yerkes Natl Primate Res Ctr, Atlanta, GA 30322 USA.
[Vargas-Inchaustegui, Diego A.; Cofano, Egidio Brocca; Robert-Guroff, Marjorie] NCI, Vaccine Branch, NIH, Bethesda, MD 20892 USA.
[Johnson, Welkin E.] Boston Coll, Dept Biol, Chestnut Hill, MA 02167 USA.
[Polonis, Victoria R.] Walter Reed Army Inst Res, Mil HIV Res Program, Silver Spring, MD USA.
[Forthal, Donald N.] Univ Calif Irvine, Irvine Sch Med, Dept Med, Div Infect Dis, Irvine, CA USA.
[Loret, Erwann P.] Aix Marseille Univ, CNRS, Fac Pharm, ETRAV Lab, F-13385 Marseille 5, France.
RP Ruprecht, RM (reprint author), Texas Biomed Res Inst, POB 760549, San Antonio, TX 78245 USA.
EM rruprecht@txbiomed.org
FU NIH [R01 AI100703, P01 AI048240, AI095092]; Intramural Research Program
of the NIH, National Cancer Institute; Office of Research Infrastructure
Programs [OD P51 OD011132, OD P51 OD011133]; NCRR [P51 RR13986]
FX We thank Stephanie Ehnert, Chris Souder and Kalpana Patel from the YNPRC
for assistance with the primate studies. We acknowledge ABL, Inc. for
the production of the clade C gp145 protein. This work was supported by
NIH grants R01 AI100703 to RMR and P01 AI048240 to RMR, SLH, RAR and
JLE. This project was also funded in part by the Intramural Research
Program of the NIH, National Cancer Institute and by the Office of
Research Infrastructure Programs/OD P51 OD011132 to the YNPRC and OD P51
OD011133 (previously NCRR grant P51 RR13986) to the Southwest National
Primate Research Center. The work conducted by WEJ was supported by NIH
grant AI095092.
NR 64
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U1 0
U2 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
EI 1873-2518
J9 VACCINE
JI Vaccine
PD NOV 12
PY 2014
VL 32
IS 48
BP 6527
EP 6536
DI 10.1016/j.vaccine.2014.08.065
PG 10
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA AU2SY
UT WOS:000345469000032
PM 25245933
ER
PT J
AU Zander, NE
Dong, H
Steele, J
Grant, JT
AF Zander, Nicole E.
Dong, Hong
Steele, Joshua
Grant, John T.
TI Metal Cation Cross-Linked Nanocellulose Hydrogels as Tissue Engineering
Substrates
SO ACS APPLIED MATERIALS & INTERFACES
LA English
DT Article
DE nanocellulose; tissue engineering; fibroblasts; fibronectin; XPS; FTIR
ID NATIVE CELLULOSE; SCAFFOLDS; NANOTECHNOLOGY; PROLIFERATION; FIBRONECTIN;
BIOACTIVITY; ADSORPTION; EXTRACTION; ATTACHMENT; NANOFIBERS
AB The use of cellulose materials for biomedical applications is attractive due to their low cost, biocompatibility, and biodegradability. Specific processing of cellulose to yield nanofibrils further improves mechanical properties and suitability as a tissue engineering substrate due to the similarity to the fibrous structure, porosity, and size-scale of the native extracellular matrix. In order to generate the substrate, nanocellulose hydrogels were fabricated from carboxylated cellulose nanofibrils via hydrogelation using metal salts. Hydrogels cross-linked with Ca2+ and Fe3+ were investigated as tissue culture substrates for C3H10T1/2 fibroblast cells. Control substrates as well as those with physically adsorbed and covalently attached fibronectin protein were evaluated with X-ray photoelectron spectroscopy (XPS), Fourier transform infrared (FTIR), and enzyme linked immunosorbent assay (ELISA). Significantly more cells were attached to surfaces modified with protein, with the highest number of cells adhered to the calcium cross-linked hydrogels with covalently attached protein.
C1 [Zander, Nicole E.; Dong, Hong; Steele, Joshua] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
[Dong, Hong] Bowhead Sci & Technol LLC, Belcamp, MD 21017 USA.
[Grant, John T.] Univ Dayton, Res Inst, Dayton, OH 45324 USA.
RP Zander, NE (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
EM nicole.e.zander.civ@mail.mil
NR 34
TC 10
Z9 10
U1 9
U2 47
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1944-8244
J9 ACS APPL MATER INTER
JI ACS Appl. Mater. Interfaces
PD NOV 12
PY 2014
VL 6
IS 21
BP 18502
EP 18510
DI 10.1021/am506007z
PG 9
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary
SC Science & Technology - Other Topics; Materials Science
GA AT5IY
UT WOS:000344978200021
PM 25295848
ER
PT J
AU Matsumoto, M
Lee, SJ
Waters, ML
Gagne, MR
AF Matsumoto, Masaomi
Lee, Stephen J.
Waters, Marcey L.
Gagne, Michel R.
TI A Catalyst Selection Protocol That Identifies Biomimetic Motifs from
beta-Hairpin Libraries
SO JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Article
ID HISTIDINE-ASPARTATE COUPLE; GENERAL-ACID CATALYSIS; BARRIER
HYDROGEN-BOND; SERINE PROTEASES; ACYL-TRANSFER; AROMATIC INTERACTIONS;
ACTIVE-SITE; COMBINATORIAL APPROACH; ASYMMETRIC CATALYSIS; ESTER
HYDROLYSIS
AB Assaying a solid-phase library of histidine-containing beta-hairpin peptides by a reactive tagging scheme in organic solvents selects for catalysts that reproduce the strategies used by His-based enzyme active sites to accelerate acyl- and phosphonyl-transfer reactions. Rate accelerations (k(rel)) in organic solvents of up to 2.4 x 10(8) are observed.
C1 [Matsumoto, Masaomi; Waters, Marcey L.; Gagne, Michel R.] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA.
[Lee, Stephen J.] US Army, Res Off, Res Triangle Pk, NC 27709 USA.
RP Waters, ML (reprint author), Univ N Carolina, Dept Chem, CB 3290, Chapel Hill, NC 27599 USA.
EM mlwaters@unc.edu; mgagne@unc.edu
FU Defense Threat Reduction Agency [HDTRA1-10-1-0030]; Army Research
Office; NRC
FX For financial support, M.R.G. and M.L.W. acknowledge the Defense Threat
Reduction Agency (HDTRA1-10-1-0030), S.J.L. acknowledges the Army
Research Office, and M.M. acknowledges a postdoctoral fellowship from
the NRC.
NR 52
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Z9 10
U1 2
U2 35
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0002-7863
J9 J AM CHEM SOC
JI J. Am. Chem. Soc.
PD NOV 12
PY 2014
VL 136
IS 45
BP 15817
EP 15820
DI 10.1021/ja503012g
PG 4
WC Chemistry, Multidisciplinary
SC Chemistry
GA AT4JQ
UT WOS:000344906100003
PM 25347708
ER
PT J
AU Jaiswal, A
Tian, LM
Tadepalli, S
Liu, KK
Fei, M
Farrell, ME
Pellegrino, PM
Singamaneni, S
AF Jaiswal, Amit
Tian, Limei
Tadepalli, Sirimuvva
Liu, Keng-ku
Fei, Max
Farrell, Mikella E.
Pellegrino, Paul M.
Singamaneni, Srikanth
TI Plasmonic Nanorattles with Intrinsic Electromagnetic Hot-Spots for
Surface Enhanced Raman Scattering
SO SMALL
LA English
DT Article
ID GOLD NANO-OCTAHEDRA; METALLIC NANOPARTICLES; NANOSPHERE LITHOGRAPHY;
CHEMICAL-DETECTION; CLUSTER ARRAYS; SERS; SPECTROSCOPY; PAPER;
NANOSTRUCTURES; RESONANCE
C1 [Jaiswal, Amit; Tian, Limei; Tadepalli, Sirimuvva; Liu, Keng-ku; Fei, Max; Singamaneni, Srikanth] Washington Univ, Inst Mat Sci & Engn, Dept Mech Engn & Mat Sci, St Louis, MO 63130 USA.
[Farrell, Mikella E.; Pellegrino, Paul M.] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
RP Singamaneni, S (reprint author), Washington Univ, Inst Mat Sci & Engn, Dept Mech Engn & Mat Sci, St Louis, MO 63130 USA.
EM singamaneni@wustl.edu
OI Tadepalli, Sirimuvva/0000-0001-9658-9988
FU Army Research Office (ARO); Army Research Lab (ARL) [W911NF-11-2-0091];
National Science Foundation [CBET-1254399]
FX A.J. and L.T. contributed equally to this work. The work was supported
by Army Research Office (ARO) and Army Research Lab (ARL) under Contract
No. W911NF-11-2-0091 and National Science Foundation under CBET-1254399.
The authors thank Nano Research Facility (NRF), a member of the National
Nanotechnology Infrastructure Network (NNIN), for providing access to
electron microscopy facilities.
NR 50
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U1 3
U2 64
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY
SN 1613-6810
EI 1613-6829
J9 SMALL
JI Small
PD NOV 12
PY 2014
VL 10
IS 21
BP 4287
EP 4292
DI 10.1002/smll.201401278
PG 6
WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied;
Physics, Condensed Matter
SC Chemistry; Science & Technology - Other Topics; Materials Science;
Physics
GA AT4IT
UT WOS:000344903500009
PM 25045064
ER
PT J
AU Khavrutskii, IV
Legler, PM
Friedlander, AM
Wallqvist, A
AF Khavrutskii, Ilja V.
Legler, Patricia M.
Friedlander, Arthur M.
Wallqvist, Anders
TI A Reaction Path Study of the Catalysis and Inhibition of the Bacillus
anthracis CapD gamma-Glutamyl Transpeptidase
SO BIOCHEMISTRY
LA English
DT Article
ID TERMINAL NUCLEOPHILE HYDROLASE; SUBSTRATE-ASSISTED CATALYSIS; PENICILLIN
ACYLASE; CRYSTAL-STRUCTURES; ESCHERICHIA-COLI; QUANTUM-MECHANICS; LETHAL
TOXIN; ENZYME; CAPSULE; ONIOM
AB The CapD enzyme of Bacillus anthracis is a gamma-glutamyl transpeptidase from the N-terminal nucleophile hydrolase superfamily that covalently anchors the poly-gamma-d-glutamic acid (pDGA) capsule to the peptidoglycan. The capsule hinders phagocytosis of B. anthracis by host cells and is essential for virulence. The role CapD plays in capsule anchoring and remodeling makes the enzyme a promising target for anthrax medical countermeasures. Although the structure of CapD is known, and a covalent inhibitor, capsidin, has been identified, the mechanisms of CapD catalysis and inhibition are poorly understood. Here, we used a computational approach to map out the reaction steps involved in CapD catalysis and inhibition. We found that the rate-limiting step of either CapD catalysis or inhibition was a concerted asynchronous formation of the tetrahedral intermediate with a barrier of 22-23 kcal/mol. However, the mechanisms of these reactions differed for the two amides. The formation of the tetrahedral intermediate with pDGA was substrate-assisted with two proton transfers. In contrast, capsidin formed the tetrahedral intermediate in a conventional way with one proton transfer. Interestingly, capsidin coupled a conformational change in the catalytic residue of the tetrahedral intermediate to stretching of the scissile amide bond. Furthermore, capsidin took advantage of iminol-amide tautomerism of its diacetamide moiety to convert the tetrahedral intermediate to the acetylated CapD. As evidence of the promiscuous nature of CapD, the enzyme cleaved the amide bond of capsidin by attacking it on the opposite side compared to pDGA.
C1 [Khavrutskii, Ilja V.; Wallqvist, Anders] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Dept Def Biotechnol High Performance Comp Softwar, Ft Detrick, MD 21702 USA.
[Legler, Patricia M.] Naval Res Labs, Ctr Biomol Sci & Engn, Washington, DC 20375 USA.
[Friedlander, Arthur M.] US Army Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
RP Khavrutskii, IV (reprint author), US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Dept Def Biotechnol High Performance Comp Softwar, Ft Detrick, MD 21702 USA.
EM ikhavrutskii@bhsai.org
FU Defense Threat Reduction Agency [CBM.THERB.02.11.RD.012]
FX This work was sponsored by Defense Threat Reduction Agency Grant
CBM.THERB.02.11.RD.012.
NR 56
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Z9 3
U1 2
U2 28
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0006-2960
J9 BIOCHEMISTRY-US
JI Biochemistry
PD NOV 11
PY 2014
VL 53
IS 44
BP 6954
EP 6967
DI 10.1021/bi500623c
PG 14
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA AT4JJ
UT WOS:000344905400011
PM 25334088
ER
PT J
AU Golecki, HM
Yuan, HY
Glavin, C
Potter, B
Badrossamay, MR
Goss, JA
Phillips, MD
Parker, KK
AF Golecki, Holly McIlwee
Yuan, Hongyan
Glavin, Calla
Potter, Benjamin
Badrossamay, Mohammad R.
Goss, Josue A.
Phillips, Michael D.
Parker, Kevin Kit
TI Effect of Solvent Evaporation on Fiber Morphology in Rotary Jet Spinning
SO LANGMUIR
LA English
DT Article
ID NANOFIBERS; MODEL; DIAMETER; DEVICES
AB The bulk production of polymeric nanofibers is important for fabricating high-performance, nanoscale materials. Rotary jet spinning (RJS) enables the mass production of nanostructured fibers by centrifugal forces but may result in inconsistent surface morphologies. Because nanofiber performance is dependent upon its surface features, we asked which parameters must be optimized during production to control fiber morphology. We developed and tested a mathematical model that describes how the competition between fluid instability and solvent removal in RJS regulates the degree of beading in fibers. Our data suggest that solvent evaporation during the spinning process causes an increase in jet viscosity and that these changes inhibit both bead formation and jet thinning. The RJS was used to vary experimental parameters, showing that fiber beading can be reduced by increasing solvent volatility, solution viscosity, and spinning velocity. Collectively, our results demonstrate that nanofiber morphology and diameter can be precisely controlled during RJS manufacturing.
C1 [Golecki, Holly McIlwee; Yuan, Hongyan; Glavin, Calla; Potter, Benjamin; Badrossamay, Mohammad R.; Goss, Josue A.; Phillips, Michael D.; Parker, Kevin Kit] Harvard Univ, Dis Biophys Grp, Wyss Inst Biol Inspired Engn, Sch Engn & Appl Sci, Cambridge, MA 02138 USA.
[Glavin, Calla; Potter, Benjamin; Phillips, Michael D.; Parker, Kevin Kit] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA.
RP Parker, KK (reprint author), Harvard Univ, Dis Biophys Grp, Wyss Inst Biol Inspired Engn, Sch Engn & Appl Sci, Cambridge, MA 02138 USA.
EM kkparker@seas.harvard.edu
FU Wyss Institute for Biologically Inspired Engineering, Harvard University
Materials Research Science and Engineering Center (MRSEC); Harvard
University Nanoscale Science and Engineering Center (NSEC); Harvard
Center for Nanoscale Systems (CNS); National Science Foundation Graduate
Research Fellowship Program
FX The authors acknowledge L. Mahadevan for helpful discussions. The
authors thank Leila F. Deravi and Alexander P. Nesmith for reviewing the
manuscript. The authors acknowledge financial support of this work from
Wyss Institute for Biologically Inspired Engineering, Harvard University
Materials Research Science and Engineering Center (MRSEC), Harvard
University Nanoscale Science and Engineering Center (NSEC), and Harvard
Center for Nanoscale Systems (CNS). Holly McIlwee Golecki acknowledges
the National Science Foundation Graduate Research Fellowship Program.
NR 25
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Z9 12
U1 2
U2 37
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0743-7463
J9 LANGMUIR
JI Langmuir
PD NOV 11
PY 2014
VL 30
IS 44
BP 13369
EP 13374
DI 10.1021/la5023104
PG 6
WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science,
Multidisciplinary
SC Chemistry; Materials Science
GA AT4JG
UT WOS:000344905100029
PM 25353398
ER
PT J
AU Campione, S
de Ceglia, D
Guclu, C
Vincenti, MA
Scalora, M
Capolino, F
AF Campione, Salvatore
de Ceglia, Domenico
Guclu, Caner
Vincenti, Maria A.
Scalora, Michael
Capolino, Filippo
TI Fano collective resonance as complex mode in a two-dimensional planar
metasurface of plasmonic nanoparticles
SO APPLIED PHYSICS LETTERS
LA English
DT Article
ID LEAKY MODES; NANOCLUSTERS; NANOSPHERES; CLUSTERS
AB Fano resonances are features in transmissivity/reflectivity/absorption that owe their origin to the interaction between a broad bright resonance and a dark (i.e., sub-radiant) narrower one. They may emerge in the optical properties of planar two-dimensional (2D) periodic arrays (metasurfaces) of plasmonic nanoparticles. In this letter, we provide a thorough assessment of their nature for the general case of normal and oblique plane wave incidence, highlighting when a Fano resonance is affected by the mutual coupling in an array and its capability to support free modal solutions. We analyze the representative case of a metasurface of plasmonic nanoshells at ultraviolet frequencies and compute its absorption under TE- and TM-polarized, oblique plane-wave incidence. In particular, we find that plasmonic metasurfaces display two distinct types of resonances observable as absorption peaks: one is related to the Mie electric dipolar resonance of each nanoparticle and the other is due to the forced excitation of free modes with small attenuation constant, usually found at oblique incidence. The latter is thus an array-induced collective Fano resonance. This realization opens up to manifold flexible designs at optical frequencies mixing individual and collective resonances. We explain the physical origin of such Fano resonances using the modal analysis through which we calculate the free modes with complex wavenumber supported by the metasurface. We define equivalent array dipolar polarizabilities that are directly related to the absorption physics at oblique incidence and show a direct dependence between array modal phase and attenuation constants and Fano resonances. We thus provide a more complete picture of Fano resonances that may lead to the design of filters, energy-harvesting devices, photodetectors, and sensors at ultraviolet frequencies. Similar resonances may be also extended to the visible range with an appropriate choice of geometries and materials. (C) 2014 AIP Publishing LLC.
C1 [Campione, Salvatore; Guclu, Caner; Capolino, Filippo] Univ Calif Irvine, Dept Elect Engn & Comp Sci, Irvine, CA 92697 USA.
[de Ceglia, Domenico; Vincenti, Maria A.] Natl Res Council AMRDEC, Charles M Bowden Res Lab, Redstone Arsenal, AL 35898 USA.
[Scalora, Michael] US Army RDECOM, AMRDEC, Charles M Bowden Res Lab, Redstone Arsenal, AL 35898 USA.
RP Campione, S (reprint author), Sandia Natl Labs, Ctr Integrated Nanotechnol, POB 5800, Albuquerque, NM 87185 USA.
EM sncampi@sandia.gov; f.capolino@uci.edu
RI Campione, Salvatore/A-2349-2015
OI Campione, Salvatore/0000-0003-4655-5485
FU National Science Foundation [CM.MI-1101074]; National Research Council
Research Associateship award at the U.S. Army Aviation and Missile
Research Development and Engineering Center
FX S.C., C. G., and F. C. acknowledge partial support from the National
Science Foundation under Grant No. CM.MI-1101074. This research was
performed while the authors D.d.C. and M. A. V. held a National Research
Council Research Associateship award at the U.S. Army Aviation and
Missile Research Development and Engineering Center.
NR 32
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U1 8
U2 80
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0003-6951
EI 1077-3118
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD NOV 10
PY 2014
VL 105
IS 19
AR 191107
DI 10.1063/1.4901183
PG 5
WC Physics, Applied
SC Physics
GA AT8YZ
UT WOS:000345216100007
ER
PT J
AU Ananworanich, J
Datta, AA
Fletcher, JL
Townamchai, N
Chomchey, N
Kroon, E
Sereti, I
Valcour, V
Kim, JH
AF Ananworanich, Jintanat
Datta, Anandita A.
Fletcher, James Lk
Townamchai, Natavudh
Chomchey, Nitiya
Kroon, Eugene
Sereti, Irini
Valcour, Victor
Kim, Jerome H.
TI Acute tubular nephropathy in a patient with acute HIV infection: review
of the literature
SO AIDS RESEARCH AND THERAPY
LA English
DT Article
DE HIV; Acute renal failure; Acute tubular nephropathy; Acute retroviral
syndrome; Acute HIV infection; Elderly
ID IMMUNODEFICIENCY-VIRUS-INFECTION; RISK
AB We report a 57-year old man with diabetes mellitus and hypertension who presented with acute HIV infection. Routine blood tests showed an elevated blood urea nitrogen and creatinine. Renal biopsy showed acute tubular nephropathy, which has not been reported to occur during acute HIV infection, in the absence of rhabdomyolysis or multiple organ system failure. Antiretroviral therapy was initiated. His renal failure gradually resolved without further intervention. At one year of follow-up his HIV RNA was undetectable, and his renal function was normal. The case illustrates a rare manifestation of acute HIV infection - acute renal failure - in an older man with diabetes and hypertension. In this setting acute kidney injury might mistakenly have been attributed to his chronic comorbidities, and this case supports early HIV-1 testing in the setting of a high index of suspicion.
C1 [Ananworanich, Jintanat; Fletcher, James Lk; Chomchey, Nitiya; Kroon, Eugene] Thai Red Cross AIDS Res Ctr, SEARCH, Bangkok, Thailand.
[Ananworanich, Jintanat; Townamchai, Natavudh] Chulalongkorn Univ, Dept Med, Fac Med, Bangkok 10330, Thailand.
[Ananworanich, Jintanat; Kim, Jerome H.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA.
[Ananworanich, Jintanat] Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Bethesda, MD 20817 USA.
[Datta, Anandita A.] Joint Pathol Ctr, Div Nephropathol, Silver Spring, MD 20910 USA.
[Sereti, Irini] Lab Immunoregulat, Clin & Mol Retrovirol Sect, Bethesda, MD 20892 USA.
[Valcour, Victor] Univ Calif San Francisco, Memory & Aging Ctr, San Francisco, CA 94143 USA.
RP Ananworanich, J (reprint author), Thai Red Cross AIDS Res Ctr, SEARCH, Bangkok, Thailand.
EM jananworanich@hivresearch.org
FU Thai Red Cross AIDS Research Center; US Military HIV Research Program;
US National Institute of Allergy and Infectious Diseases
FX We are grateful to Dr. Anchalee Avihingsanon, Dr. Opass Putcharoen, Ms.
Peeriya Mangu, Ms. Duanghathai Suttichom and Ms. Sasiwimol Ubolyam for
facilitating the clinical care of this patient. We thank Ms. Piraporn
June Ohata for helping to prepare and submit the manuscript. This work
was supported by the intramural research programs at the Thai Red Cross
AIDS Research Center, US Military HIV Research Program and the US
National Institute of Allergy and Infectious Diseases.
NR 15
TC 0
Z9 0
U1 0
U2 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1742-6405
J9 AIDS RES THER
JI Aids Res. Ther.
PD NOV 7
PY 2014
VL 11
AR 34
DI 10.1186/1742-6405-11-34
PG 6
WC Infectious Diseases
SC Infectious Diseases
GA AX4YP
UT WOS:000346935000001
PM 25745498
ER
PT J
AU Ettisserry, DP
Goldsman, N
Akturk, A
Lelis, AJ
AF Ettisserry, D. P.
Goldsman, N.
Akturk, A.
Lelis, A. J.
TI Structure, bonding, and passivation of single carbon-related oxide hole
traps near 4H-SiC/SiO2 interfaces
SO JOURNAL OF APPLIED PHYSICS
LA English
DT Article
ID SIO2; SILICA; SITES
AB Single carbon interstitial in silicon dioxide, existing in carboxyl configuration, is shown to act as a border hole trap near 4H-SiC/SiO2 interface. Using density functional theory-based formation energy considerations, it is found to switch charge state between +2 and neutral as the 4H-SiC Fermi level sweeps its charge transition level located 1.4 eV above 4H-SiC valence band edge. Thus, carboxyl defect is predicted to be a potential candidate for threshold voltage instability in 4H-SiC MOSFETs. Post oxidation annealing of the interface with nitric oxide is shown to remove carboxyl defects. However, treating the defect in H-2 creates a hole trap level at 1.1 eV above 4H-SiC valence band edge similar to the original carboxyl defect. The stability of carboxyl and H2 treated carboxyl defects in their doubly positive state is explained on the basis of their structural and bonding transformations during hole capture. These include puckering and back-bonding of silicon with lattice oxygen as in the well-known oxygen vacancy (E' center) hole traps and an increase in the bond order between carboxyl carbon and oxygen. (C) 2014 AIP Publishing LLC.
C1 [Ettisserry, D. P.; Goldsman, N.; Akturk, A.] Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA.
[Goldsman, N.; Akturk, A.] CoolCAD Elect, College Pk, MD 20740 USA.
[Lelis, A. J.] US Army Res Lab, Adelphi, MD 20783 USA.
RP Ettisserry, DP (reprint author), Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA.
EM deva@umd.edu
OI Ettisserry, Devanarayanan/0000-0002-4214-2141
NR 39
TC 4
Z9 4
U1 2
U2 44
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0021-8979
EI 1089-7550
J9 J APPL PHYS
JI J. Appl. Phys.
PD NOV 7
PY 2014
VL 116
IS 17
AR 174502
DI 10.1063/1.4900981
PG 7
WC Physics, Applied
SC Physics
GA AT7ZH
UT WOS:000345152900058
ER
PT J
AU Brown, TN
O'Donovan, M
Hasselquist, L
Corner, B
Schiffman, JM
AF Brown, Tyler N.
O'Donovan, Meghan
Hasselquist, Leif
Corner, Brian
Schiffman, Jeffrey M.
TI Soldier-relevant loads impact lower limb biomechanics during anticipated
and unanticipated single-leg cutting movements
SO JOURNAL OF BIOMECHANICS
LA English
DT Article
DE Joint power; Kinematics; Kinetics; Locomotion; Backpack; Stance time
ID LOWER-EXTREMITY BIOMECHANICS; CRUCIATE LIGAMENT INJURY; JOINT COORDINATE
SYSTEM; GROUND REACTION FORCES; KNEE-JOINT; SPATIOTEMPORAL PARAMETERS;
DROP-LANDINGS; BACKPACK LOAD; ACL INJURY; KINEMATICS
AB This study quantified how body borne load impacts hip and knee biomechanics during anticipated and unanticipated single-leg cutting maneuvers. Fifteen male military personnel performed a series of single-leg cutting maneuvers with three different load configurations (light, similar to 6 kg, medium, similar to 20 kg, and heavy, similar to 40 kg). Subject-based means of the specific lower limb biomechanical variables were submitted to repeated measures ANOVA to test the main and interaction effects of body borne load and movement type. With body borne load, stance time (P<0.001) increased, while larger hip (P=0.027) and knee flexion (P=0.004), and hip adduction (P<0.001) moments, and decreased hip (P=0.002) and knee flexion (P<0.001), and hip adduction (P=0.003) postures were evident. Further, the hip (P<0.001) and ankle (P=0.024) increased energy absorption, while the knee (P=0.020) increased energy generation with body borne load. During the unanticipated maneuvers, the hip (P=0.009) and knee (P=0.032) increased energy generation, and peak hip flexion moment (P=0.002) increased relative to the anticipated movements. With the body borne load, participants adopted biomechanical patterns that decreased their locomotive ability including larger moments and reduced flexion postures of the lower limb. During the single-leg cut, participants used greater energy absorption from the large, proximal muscles of the hip and greater energy generation from the knee with the addition of load. Participant's performance when carrying a range of loads was not compromised by anticipation, as they did not exhibit the hip and knee kinetic and kinematic adaptations previously demonstrated when reacting to an unplanned stimulus. Published by Elsevier Ltd.
C1 [Brown, Tyler N.] Oak Ridge Inst Sci & Educ, Belcamp, MD USA.
[Brown, Tyler N.; O'Donovan, Meghan; Hasselquist, Leif; Corner, Brian; Schiffman, Jeffrey M.] US Army, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA.
[Schiffman, Jeffrey M.] Liberty Mutual Res Inst Safety, Hopkinton, MA USA.
RP Brown, TN (reprint author), Natick Soldier RD & E Ctr, Dept Army, 15 Kansas St, Natick, MA 01760 USA.
EM tyler.n.brown4.civ@mail.mil
FU Competitive In-house Laboratory Independent Research (ILIR) Award
program from the Department of the Army, Office of the Assistant
Secretary of the Army - Acquisition Logistics and Technology
FX This work was supported by a FY 2012-2014 Competitive In-house
Laboratory Independent Research (ILIR) Award program from the Department
of the Army, Office of the Assistant Secretary of the Army - Acquisition
Logistics and Technology. The authors thank Ms. Marina Carboni and Mr.
Albert Adams for their assistance with this study.
NR 47
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Z9 5
U1 0
U2 15
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0021-9290
EI 1873-2380
J9 J BIOMECH
JI J. Biomech.
PD NOV 7
PY 2014
VL 47
IS 14
BP 3494
EP 3501
DI 10.1016/j.jbiomech.2014.09.002
PG 8
WC Biophysics; Engineering, Biomedical
SC Biophysics; Engineering
GA AT8KZ
UT WOS:000345183500010
PM 25257813
ER
PT J
AU AbdulHameed, MDM
Tawa, GJ
Kumar, K
Ippolito, DL
Lewis, JA
Stallings, JD
Wallqvist, A
AF AbdulHameed, Mohamed Diwan M.
Tawa, Gregory J.
Kumar, Kamal
Ippolito, Danielle L.
Lewis, John A.
Stallings, Jonathan D.
Wallqvist, Anders
TI Systems Level Analysis and Identification of Pathways and Networks
Associated with Liver Fibrosis
SO PLOS ONE
LA English
DT Article
ID STELLATE CELL-MIGRATION; HUMAN HEART-FAILURE; LARGE GENE LISTS;
HEPATIC-FIBROSIS; PROBE LEVEL; DATA SETS; EXPRESSION; DATABASE;
MECHANISMS; INJURY
AB Toxic liver injury causes necrosis and fibrosis, which may lead to cirrhosis and liver failure. Despite recent progress in understanding the mechanism of liver fibrosis, our knowledge of the molecular-level details of this disease is still incomplete. The elucidation of networks and pathways associated with liver fibrosis can provide insight into the underlying molecular mechanisms of the disease, as well as identify potential diagnostic or prognostic biomarkers. Towards this end, we analyzed rat gene expression data from a range of chemical exposures that produced observable periportal liver fibrosis as documented in DrugMatrix, a publicly available toxicogenomics database. We identified genes relevant to liver fibrosis using standard differential expression and co-expression analyses, and then used these genes in pathway enrichment and protein-protein interaction (PPI) network analyses. We identified a PPI network module associated with liver fibrosis that includes known liver fibrosis-relevant genes, such as tissue inhibitor of metalloproteinase-1, galectin-3, connective tissue growth factor, and lipocalin-2. We also identified several new genes, such as perilipin-3, legumain, and myocilin, which were associated with liver fibrosis. We further analyzed the expression pattern of the genes in the PPI network module across a wide range of 640 chemical exposure conditions in DrugMatrix and identified early indications of liver fibrosis for carbon tetrachloride and lipopolysaccharide exposures. Although it is well known that carbon tetrachloride and lipopolysaccharide can cause liver fibrosis, our network analysis was able to link these compounds to potential fibrotic damage before histopathological changes associated with liver fibrosis appeared. These results demonstrated that our approach is capable of identifying early-stage indicators of liver fibrosis and underscore its potential to aid in predictive toxicity, biomarker identification, and to generally identify disease-relevant pathways.
C1 [AbdulHameed, Mohamed Diwan M.; Tawa, Gregory J.; Kumar, Kamal; Wallqvist, Anders] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, High Performance Comp Software Applicat Inst, Dept Def Biotechnol, Ft Detrick, MD 21702 USA.
[Ippolito, Danielle L.; Lewis, John A.; Stallings, Jonathan D.] US Army Ctr Environm Hlth Res, Ft Detrick, MD USA.
RP Wallqvist, A (reprint author), US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, High Performance Comp Software Applicat Inst, Dept Def Biotechnol, Ft Detrick, MD 21702 USA.
EM awallqvist@bhsai.org
RI AbdulHameed, Mohamed Diwan M/O-3088-2015;
OI AbdulHameed, Mohamed Diwan M/0000-0003-1483-4084; Stallings,
Jonathan/0000-0002-6430-5888; Kumar, Kamal/0000-0002-9470-6682;
wallqvist, anders/0000-0002-9775-7469
FU Military Operational Medicine Research Program; U.S. Army's Network
Science Initiative, U.S. Army Medical Research and Materiel Command
(USAMRMC); U.S. Department of Energy; USAMRMC
FX The authors were supported by the Military Operational Medicine Research
Program and the U.S. Army's Network Science Initiative, U.S. Army
Medical Research and Materiel Command (USAMRMC,
http://mrmc.amedd.army.mil), Ft. Detrick, MD. This research was
supported in part by an appointment to the Postgraduate Research
Participation Program at the U.S. Army Center for Environmental Health
Research (USACEHR, http://usacehr.amedd.army.mil) administered by the
Oak Ridge Institute for Science and Education through an interagency
agreement between the U.S. Department of Energy and USAMRMC. The funders
had no role in study design, data collection and analysis, decision to
publish, or preparation of the manuscript.
NR 84
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Z9 13
U1 3
U2 21
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD NOV 7
PY 2014
VL 9
IS 11
AR e112193
DI 10.1371/journal.pone.0112193
PG 14
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AT3WF
UT WOS:000344863100061
PM 25380136
ER
PT J
AU Atanasov, SE
Oldham, CJ
Slusarski, KA
Taggart-Scarff, J
Sherman, SA
Senecal, KJ
Filocamo, SF
McAllister, QP
Wetzel, ED
Parsons, GN
AF Atanasov, Sarah E.
Oldham, Christopher J.
Slusarski, Kyle A.
Taggart-Scarff, Joshua
Sherman, Shalli A.
Senecal, Kris J.
Filocamo, Shaun F.
McAllister, Quinn P.
Wetzel, Eric D.
Parsons, Gregory N.
TI Improved cut-resistance of Kevlar (R) using controlled interface
reactions during atomic layer deposition of ultrathin (< 50 angstrom)
inorganic coatings
SO JOURNAL OF MATERIALS CHEMISTRY A
LA English
DT Article
ID SHEAR THICKENING FLUID; MECHANICAL-PROPERTIES; BALLISTIC IMPACT;
THIN-FILMS; FIBERS; FABRICS; PROTECTION; POLYMERS; FAILURE; ENERGY
AB Conformal atomic layer deposition (ALD) of Al2O3 and TiO2 thin films on Kevlar (R), poly(p-phenylene terephthalamide) (PPTA) fibers at 50 and 100 degrees C affects the fiber cut resistance. Systematic studies of ALD coatings between 10 to 400 angstrom thick formed at 50 and 100 degrees C revealed excellent conformality, and trends in cutting performance depended on materials and process details. A 50 angstrom/50 angstrom TiO2/Al2O3 bilayer formed at 50 degrees C increased cut resistance of PPTA by 30% compared to untreated fiber materials. In situ infrared analysis shows that trimethylaluminum (TMA) Al2O3 precursor reacts sub-surface with PPTA and tends to degraded mechanical performance. The TiCl4 TiO2 precursor reacts to form a barrier that limits TMA/PPTA interactions, allowing a harder Al2O3 layer to form on top of TiO2. The thin ALD coatings do not substantially affect durability, flexibility, or weight of the PPTA, making ALD a potentially viable means to enhance the protective properties of Kevlar and other polymer fiber systems.
C1 [Atanasov, Sarah E.; Oldham, Christopher J.; Parsons, Gregory N.] N Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA.
[Slusarski, Kyle A.; Taggart-Scarff, Joshua; McAllister, Quinn P.; Wetzel, Eric D.] Army Res Lab, Aberdeen Proving Ground, MD USA.
[Sherman, Shalli A.; Senecal, Kris J.; Filocamo, Shaun F.] US Army Natick Res, Ctr Dev & Engn, Natick, MA USA.
RP Parsons, GN (reprint author), N Carolina State Univ, Dept Chem & Biomol Engn, Campus Box 7905, Raleigh, NC 27695 USA.
EM parsons@ncsu.edu
RI Parsons, Gregory/O-9762-2014
OI Parsons, Gregory/0000-0002-0048-5859
FU State of North Carolina; National Science Foundation; US Army
FX The authors acknowledge R. Garcia and F. Stevie at the Analytical
Instrumentation Facility (AIF) for assistance with TEM and XPS analysis,
respectively. AIF is located at North Carolina State University and is
supported by the State of North Carolina and the National Science
Foundation. We are also thankful to the US Army for funding this
research.
NR 33
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U1 3
U2 45
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 2050-7488
EI 2050-7496
J9 J MATER CHEM A
JI J. Mater. Chem. A
PD NOV 7
PY 2014
VL 2
IS 41
BP 17371
EP 17379
DI 10.1039/c4ta03662j
PG 9
WC Chemistry, Physical; Energy & Fuels; Materials Science,
Multidisciplinary
SC Chemistry; Energy & Fuels; Materials Science
GA AQ4JW
UT WOS:000342763300022
ER
PT J
AU Caballero, IS
Yen, JY
Hensley, LE
Honko, AN
Goff, AJ
Connor, JH
AF Caballero, Ignacio S.
Yen, Judy Y.
Hensley, Lisa E.
Honko, Anna N.
Goff, Arthur J.
Connor, John H.
TI Lassa and Marburg viruses elicit distinct host transcriptional responses
early after infection
SO BMC GENOMICS
LA English
DT Article
DE Transcriptomics; Transcriptional response; Lassa virus; Marburg virus;
Interferon-stimulated genes; Biomarker; Gene expression profile; Early
stage diagnostics
ID DIFFERENTIAL EXPRESSION ANALYSIS; HEMORRHAGIC-FEVER; CYNOMOLGUS
MACAQUES; IMMUNE-RESPONSE; WEST-AFRICA; IN-VITRO; RNA-SEQ; EBOLA;
APOPTOSIS; DISEASE
AB Background: Lassa virus and Marburg virus are two causative agents of viral hemorrhagic fever. Their diagnosis is difficult because patients infected with either pathogen present similar nonspecific symptoms early after infection. Current diagnostic tests are based on detecting viral proteins or nucleic acids in the blood, but these cannot be found during the early stages of disease, before the virus starts replicating in the blood. Using the transcriptional response of the host during infection can lead to earlier diagnoses compared to those of traditional methods.
Results: In this study, we use RNA sequencing to obtain a high-resolution view of the in vivo transcriptional dynamics of peripheral blood mononuclear cells (PBMCs) throughout both types of infection. We report a subset of host mRNAs, including heat-shock proteins like HSPA1B, immunoglobulins like IGJ, and cell adhesion molecules like SIGLEC1, whose differences in expression are strong enough to distinguish Lassa infection from Marburg infection in non-human primates. We have validated these infection-specific expression differences by using microarrays on a larger set of samples, and by quantifying the expression of individual genes using RT-PCR.
Conclusions: These results suggest that host transcriptional signatures are correlated with specific viral infections, and that they can be used to identify highly pathogenic viruses during the early stages of disease, before standard detection methods become effective.
C1 [Caballero, Ignacio S.] Boston Univ, Bioinformat Grad Program, Boston, MA 02215 USA.
[Yen, Judy Y.; Connor, John H.] Boston Univ, Dept Microbiol, Sch Med, Boston, MA 02118 USA.
[Hensley, Lisa E.; Honko, Anna N.; Goff, Arthur J.] US Army, Div Virol, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
[Hensley, Lisa E.; Honko, Anna N.] NIAID, Integrated Res Facil Ft Detrick, NIH, Ft Detrick, MD 21702 USA.
RP Caballero, IS (reprint author), Boston Univ, Bioinformat Grad Program, 24 Cummington St, Boston, MA 02215 USA.
EM nacho@bu.edu
OI Connor, John/0000-0002-8867-7256; Honko, Anna/0000-0001-9165-148X
FU National Institutes of Health [R01 AI1096159]; United States Army
[W81XWH 100-02-0008, 11-02-0130]; Fulbright Commission Spain; Regional
Government of Andalusia
FX This work was supported by the National Institutes of Health grant R01
AI1096159, and the United States Army contracts W81XWH 100-02-0008 and
11-02-0130. ISC was supported by the Fulbright Commission Spain and the
Regional Government of Andalusia. The funders had no role in study
design, data collection and analysis, decision to publish, or
preparation of the manuscript.
NR 55
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U1 0
U2 7
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2164
J9 BMC GENOMICS
JI BMC Genomics
PD NOV 6
PY 2014
VL 15
AR 960
DI 10.1186/1471-2164-15-960
PG 12
WC Biotechnology & Applied Microbiology; Genetics & Heredity
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA AT9MH
UT WOS:000345250900001
PM 25377889
ER
PT J
AU Yuan, H
Newton, DL
Seymour, LA
Metz, A
Cropek, D
Holder, AA
Ofoli, RY
AF Yuan, Hao
Newton, De'Andra L.
Seymour, Luke A.
Metz, Anja
Cropek, Donald
Holder, Alvin A.
Ofoli, Robert Y.
TI Characterization and functional assessment of a cobalt(III)-oxo cubane
cluster water oxidation catalyst immobilized on ITO
SO CATALYSIS COMMUNICATIONS
LA English
DT Article
DE Electrochemical deposition; Catalyst recycle; Cyclic voltammetry;
Artificial photosynthesis
ID OXYGEN-EVOLVING COMPLEX; SYNTHETIC MODEL; PHOTOSYSTEM-II; CORE
AB A cobalt(III) oxo cubane water oxidation catalyst, a structural mimic of the natural oxygen-evolving center, was immobilized on indium tin oxide (ITO) to promote recycling. The structure and composition of the complex were characterized by Fourier transform-infrared (FT-IR) spectroscopy, surface FT-IR, scanning electron microscopy, and energy dispersive X-ray spectroscopy. Cyclic voltammetry was used to assess catalyst functionality, stability, and recyclability. The results showed that this catalyst can be successfully immobilized on ITO, and that the complex functions in the same manner as the free catalyst in solution. This separation of synthesis and immobilization has great potential for optimizing heterogeneous catalysts. (C) 2014 Published by Elsevier B.V.
C1 [Yuan, Hao; Ofoli, Robert Y.] Michigan State Univ, Dept Chem Engn & Mat Sci, E Lansing, MI 48824 USA.
[Newton, De'Andra L.; Seymour, Luke A.; Holder, Alvin A.] Old Dominion Univ, Dept Chem & Biochem, Norfolk, VA 23529 USA.
[Metz, Anja; Cropek, Donald] US Army Corps Engineers, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA.
RP Ofoli, RY (reprint author), Michigan State Univ, Dept Chem Engn & Mat Sci, E Lansing, MI 48824 USA.
EM ofoli@egr.msu.edu
RI Holder, Alvin/B-6329-2016
OI Holder, Alvin/0000-0001-9618-5297
FU U.S. Army Engineer Research and Development Center (Construction
Engineering Research Laboratory) [W9132T-10-2-0025]
FX This research was supported in part by the U.S. Army Engineer Research
and Development Center (Construction Engineering Research Laboratory)
(W9132T-10-2-0025), administered by the Oak Ridge Institute for Science
and Education through an interagency agreement between the U.S.
Department of Energy and ERDC-CERL.
NR 11
TC 7
Z9 7
U1 3
U2 43
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1566-7367
EI 1873-3905
J9 CATAL COMMUN
JI Catal. Commun.
PD NOV 5
PY 2014
VL 56
BP 76
EP 80
DI 10.1016/j.catcom.2014.06.007
PG 5
WC Chemistry, Physical
SC Chemistry
GA AP7JB
UT WOS:000342252500017
ER
PT J
AU Akhvlediani, T
Bautista, CT
Shakarishvili, R
Tsertsvadze, T
Imnadze, P
Tatishvili, N
Davitashvili, T
Samkharadze, T
Chlikadze, R
Dvali, N
Dzigua, L
Karchava, M
Gatserelia, L
Macharashvili, N
Kvirkvelia, N
Habashy, EE
Farrell, M
Rowlinson, E
Sejvar, J
Hepburn, M
Pimentel, G
Dueger, E
House, B
Rivard, R
AF Akhvlediani, Tamar
Bautista, Christian T.
Shakarishvili, Roman
Tsertsvadze, Tengiz
Imnadze, Paata
Tatishvili, Nana
Davitashvili, Tamar
Samkharadze, Tamar
Chlikadze, Rusudan
Dvali, Natia
Dzigua, Lela
Karchava, Mariam
Gatserelia, Lana
Macharashvili, Nino
Kvirkvelia, Nana
Habashy, Engy Emil
Farrell, Margaret
Rowlinson, Emily
Sejvar, James
Hepburn, Matthew
Pimentel, Guillermo
Dueger, Erica
House, Brent
Rivard, Robert
TI Etiologic Agents of Central Nervous System Infections among Febrile
Hospitalized Patients in the Country of Georgia
SO PLOS ONE
LA English
DT Article
ID BACTERIAL-MENINGITIS; VIRAL-INFECTIONS; ENCEPHALITIS; EPIDEMIOLOGY;
DIAGNOSIS
AB Objectives: There is a large spectrum of viral, bacterial, fungal, and prion pathogens that cause central nervous system (CNS) infections. As such, identification of the etiological agent requires multiple laboratory tests and accurate diagnosis requires clinical and epidemiological information. This hospital-based study aimed to determine the main causes of acute meningitis and encephalitis and enhance laboratory capacity for CNS infection diagnosis.
Methods: Children and adults patients clinically diagnosed with meningitis or encephalitis were enrolled at four reference health centers. Cerebrospinal fluid (CSF) was collected for bacterial culture, and in-house and multiplex RT-PCR testing was conducted for herpes simplex virus (HSV) types 1 and 2, mumps virus, enterovirus, varicella zoster virus (VZV), Streptococcus pneumoniae, HiB and Neisseria meningitidis.
Results: Out of 140 enrolled patients, the mean age was 23.9 years, and 58% were children. Bacterial or viral etiologies were determined in 51% of patients. Five Streptococcus pneumoniae cultures were isolated from CSF. Based on in-house PCR analysis, 25 patients were positive for S. pneumoniae, 6 for N. meningitidis, and 1 for H. influenzae. Viral multiplex PCR identified infections with enterovirus (n = 26), VZV (n = 4), and HSV-1 (n = 2). No patient was positive for mumps or HSV-2.
Conclusions: Study findings indicate that S. pneumoniae and enteroviruses are the main etiologies in this patient cohort. The utility of molecular diagnostics for pathogen identification combined with the knowledge provided by the investigation may improve health outcomes of CNS infection cases in Georgia.
C1 [Akhvlediani, Tamar] Javakhishvili Tbilisi State Univ, Dept Neurol & Neurosurg, Tbilisi, Rep of Georgia.
[Akhvlediani, Tamar] US Army, Med Res Unit Georgia, Tbilisi, Rep of Georgia.
[Bautista, Christian T.] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Shakarishvili, Roman] Sarajishvili Inst Clin Neurol & Neurosurg, Tbilisi, Rep of Georgia.
[Tsertsvadze, Tengiz; Davitashvili, Tamar; Dvali, Natia; Dzigua, Lela; Karchava, Mariam; Gatserelia, Lana; Macharashvili, Nino] Sci Res Ctr Infect Pathol AIDS & Clin Immunol, Tbilisi, Rep of Georgia.
[Imnadze, Paata; Chlikadze, Rusudan] Natl Ctr Dis Control & Publ Hlth, Tbilisi, Rep of Georgia.
[Tatishvili, Nana; Samkharadze, Tamar] Iashvili Childrens Hosp, Dept Neurol, Tbilisi, Rep of Georgia.
[Habashy, Engy Emil; Farrell, Margaret; Rowlinson, Emily; Pimentel, Guillermo; Dueger, Erica; House, Brent] US Naval, Global Dis Detect & Response Program, Med Res Unit 3, Cairo, Egypt.
[Sejvar, James] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA USA.
[Dueger, Erica] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA.
[Hepburn, Matthew; Rivard, Robert] US Army, Med Res Inst Infect Dis, Frederick, MD USA.
RP Akhvlediani, T (reprint author), Javakhishvili Tbilisi State Univ, Dept Neurol & Neurosurg, Tbilisi, Rep of Georgia.
EM t_akhvlediani@yahoo.com
FU U.S. Department of Defense Global Emerging Infections Surveillance
(GEIS) Program; U.S. Centers for Disease Control and Prevention
FX This work was funded by the U.S. Department of Defense Global Emerging
Infections Surveillance (GEIS) Program and supported by the U.S. Centers
for Disease Control and Prevention. The funders had no role in study
design, data collection and analysis, decision to publish, or
preparation of the manuscript.
NR 21
TC 4
Z9 4
U1 0
U2 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD NOV 4
PY 2014
VL 9
IS 11
AR e111393
DI 10.1371/journal.pone.0111393
PG 7
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA AS6XG
UT WOS:000344402000051
PM 25369023
ER
PT J
AU Alout, H
Krajacich, BJ
Meyers, JI
Grubaugh, ND
Brackney, DE
Kobylinski, KC
Diclaro, JW
Bolay, FK
Fakoli, LS
Diabate, A
Dabire, RK
Bougma, RW
Foy, BD
AF Alout, Haoues
Krajacich, Benjamin J.
Meyers, Jacob I.
Grubaugh, Nathan D.
Brackney, Doug E.
Kobylinski, Kevin C.
Diclaro, Joseph W., II
Bolay, Fatorma K.
Fakoli, Lawrence S.
Diabate, Abdoulaye
Dabire, Roch K.
Bougma, Roland W.
Foy, Brian D.
TI Evaluation of ivermectin mass drug administration for malaria
transmission control across different West African environments
SO MALARIA JOURNAL
LA English
DT Article
DE Mass drug administration; Ivermectin; Transmission; West Africa; Malaria
control; Plasmodium falciparum; Anopheles gambiae; Survival; Parity;
Environment
ID PLASMODIUM-FALCIPARUM; ANOPHELES-GAMBIAE; PARASITE TRANSMISSION;
ALBENDAZOLE; MOSQUITOS; HUMANS; IMPACT
AB Background: Mass drug administration (MDA) of ivermectin to humans for control and elimination of filarial parasites can kill biting malaria vectors and lead to Plasmodium transmission reduction. This study examines the degree and duration of mosquitocidal effects resulting from single MDAs conducted in three different West African countries, and the subsequent reductions in parity and Plasmodium sporozoite rates.
Methods: Indoor-resting, blood-fed and outdoor host-seeking Anopheles spp. were captured on days surrounding MDAs from 2008-2013 in Senegalese, Liberian and Burkinabe villages. Mortality was assessed on a portion of the indoor collection, and parity status was determined on host-seeking mosquitoes. The effect of MDA was then analysed against the time relative to the MDA, the distributed drugs and environmental variables.
Results: Anopheles gambiae survivorship was reduced by 33.9% for one week following MDA and parity rates were significantly reduced for more than two weeks after the MDAs. Sporozoite rates were significantly reduced by >77% for two weeks following the MDAs in treatment villages despite occurring in the middle of intense transmission seasons. These observed effects were consistent across three different West African transmission dynamics.
Conclusions: These data provide a comprehensive and crucial evidence base for the significant reduction in malaria transmission following single ivermectin MDAs across diverse field sites. Despite the limited duration of transmission reduction, these results support the hypothesis that repeated MDAs with optimal timing could help sustainably control malaria as well as filarial transmission.
C1 [Alout, Haoues; Krajacich, Benjamin J.; Meyers, Jacob I.; Grubaugh, Nathan D.; Brackney, Doug E.; Foy, Brian D.] Colorado State Univ, Dept Microbiol Immunol & Pathol, Arthropod Borne & Infect Dis Lab, Ft Collins, CO 80523 USA.
[Meyers, Jacob I.] Colorado State Univ, Dept Biomed Sci, Ft Collins, CO 80523 USA.
[Kobylinski, Kevin C.] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Kobylinski, Kevin C.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
[Diclaro, Joseph W., II] US Naval Med Res Unit 3, Cairo, Egypt.
[Bolay, Fatorma K.; Fakoli, Lawrence S.] Liberian Inst Biomed Res, Charlesville, Liberia.
[Diabate, Abdoulaye; Dabire, Roch K.] Inst Rech Sci Sante, Direct Reg Ouest, Bobo Dioulasso, Burkina Faso.
[Bougma, Roland W.] Minist Hlth, Ouagadougou, Burkina Faso.
RP Alout, H (reprint author), Colorado State Univ, Dept Microbiol Immunol & Pathol, Arthropod Borne & Infect Dis Lab, Ft Collins, CO 80523 USA.
EM haoues.alout@colostate.edu
RI Alout, Haoues/N-9556-2016; Foy, Brian/E-6230-2017
OI Alout, Haoues/0000-0001-7917-2697; Foy, Brian/0000-0002-9117-203X
FU National Institute of Allergy and Infectious Diseases [R21-AI079528,
R01-AI094349-01A1]; US Armed Forces Health Surveillance Center: Global
Emerging Infections Surveillance Network; Grand Challenges Explorations
from the Bill and Melinda Gates Foundation [51995]
FX We thank the local people in Senegal, Liberia and Burkina Faso for
participating in this study, as well as the local authorities for their
support. We are very grateful to the IRSS staff in Burkina Faso, to
collaborators in Senegal and to the LIBR staff in Liberia for their
technical assistance. We thank Infoscitex Corp for the use of their tent
traps in our studies. We thank Jon Seaman, Meg Gray, Timothy Burton, and
Wojtek Kuklinski for their assistance in mosquito processing. We are
very thankful to Peter U Fischer for discussion and comments. We
acknowledge and are grateful for support from National Institute of
Allergy and Infectious Diseases grants R21-AI079528 and
R01-AI094349-01A1, US Armed Forces Health Surveillance Center: Global
Emerging Infections Surveillance Network, and Grand Challenges
Explorations grant 51995 from the Bill and Melinda Gates Foundation. The
funding sources had no role in study design, data collection and
analysis, decision to publish, or preparation of the manuscript.
NR 31
TC 12
Z9 12
U1 3
U2 10
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2875
J9 MALARIA J
JI Malar. J.
PD NOV 3
PY 2014
VL 13
AR 417
DI 10.1186/1475-2875-13-417
PG 10
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA AU6LF
UT WOS:000345713900001
PM 25363349
ER
PT J
AU Valisetty, RR
Dongare, AM
Rajendran, AM
Namburu, RR
AF Valisetty, R. R.
Dongare, A. M.
Rajendran, A. M.
Namburu, R. R.
TI Atomistic Modeling of Spa 11 Response in a Single Crystal Aluminum
SO CMC-COMPUTERS MATERIALS & CONTINUA
LA English
DT Article
DE Molecular dynamics; void nucleation; spall stress; crystal orientation;
strain rate
ID VOID-GROWTH; DISLOCATION NUCLEATION; DUCTILE FRACTURE; DYNAMIC FAILURE;
YIELD CRITERIA; STRAIN RATES; SPALLATION; STRENGTH; METALS; CU
AB Materials used in soldier protective structures, such as armor, vehicles and civil infrastructures, are being improved for performance in extreme dynamic environments. Accordingly, atomistic molecular dynamics simulations were performed to study the spall response in a single crystal aluminum atom system. A planar 9.6 picoseconds (ps) shock pulse was generated through impacts with a shock piston at velocities ranging from 0.6 km/s to 1.5 km/s in three <1,0,0>, <1,1,0>, and <1,1,1> crystal orientations. In addition to characterizing the transient spall region width and duration, the spall response was characterized in terms of the traditional axial stress vs. axial strain response for gaining an understanding of the material failure in spall. Using an atom section averaging process, the snapshots, or the time history plots of the stress and strain axial distributions in the shock direction, were obtained from the MD simulations' outputs of the atom level stresses and displacements. These snapshots guided the analyses to an estimation of the spall widths and spall transients. The results were interpreted to highlight the effects of crystal orientation and impact velocity on the spall width, spall duration, spall stress, strain rate, critical strain values at the void nucleation, and the void volume fraction at the void coalescence. For all the combinations of the crystal orientations and the impact velocities, the void nucleation was observed when the stress reached a peak hydrostatic state and the stress triaxiality factor reached a minimum, i.e. by the simultaneous occurring of these three conditions for the stress state: 1. pressure reaching a negative minimum, 2. axial stress reaching the magnitude value of the peak pressure, and 3. the effective stress reaching a zero value. At these conditions, void nucleation was mainly caused by atom de-bonding. In fact, the void nucleation strains were shown to have been preceded by the strains of the stress triaxiality condition in this study, thus confirming the stress triaxiality condition for the void nucleation in spall. Based on the observation that the axial stress reached a maximum value of similar to 6 GPa during the void nucleation phase in spall and stayed approximately at that value for different crystal orientations and impact velocities, the value was proposed as a material spall strength.
C1 [Valisetty, R. R.; Namburu, R. R.] Army Res Lab, Comp & Info Sci Directorate, Aberdeen Proving Ground, MD 21005 USA.
[Dongare, A. M.] Univ Connecticut, Dept Mat Sci & Engn, Storrs, CT 06269 USA.
[Rajendran, A. M.] Univ Mississippi, Dept Mech Engn, University, MS 38677 USA.
RP Valisetty, RR (reprint author), Army Res Lab, Comp & Info Sci Directorate, Aberdeen Proving Ground, MD 21005 USA.
EM ramakrishna.r.valisetty.civ@mail.mil; dongare@uconn.edu
OI Dongare, Avinash/0000-0003-3189-3588
NR 47
TC 0
Z9 0
U1 0
U2 1
PU TECH SCIENCE PRESS
PI NORCROSS
PA 6825 JIMMY CARTER BLVD, STE 1850, NORCROSS, GA 30071 USA
SN 1546-2218
EI 1546-2226
J9 CMC-COMPUT MATER CON
JI CMC-Comput. Mat. Contin.
PD NOV
PY 2014
VL 44
IS 1
BP 23
EP 57
PG 35
WC Engineering, Multidisciplinary; Materials Science, Multidisciplinary;
Mathematics, Interdisciplinary Applications
SC Engineering; Materials Science; Mathematics
GA CO9QL
UT WOS:000359510300002
ER
PT J
AU Michael, N
Kim, J
Robb, M
Thomas, R
Haynes, B
AF Michael, Nelson
Kim, Jerome
Robb, Merlin
Thomas, Rasmi
Haynes, Barton
TI Advances in Prophylactic HIV Vaccine Development
SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
LA English
DT Meeting Abstract
CT 16th Annual International Meeting of the Institute-of-Human-Virology
(IHV)
CY SEP 14-14, 2014
CL Univ Maryland Sch Med, Baltimore, MD
SP Inst Human Virol
HO Univ Maryland Sch Med
C1 [Michael, Nelson; Kim, Jerome; Robb, Merlin; Thomas, Rasmi] Walter Reed Army Inst Res, Mil HIV Res Program, Silver Spring, MD USA.
[Haynes, Barton] Duke Univ, Med Ctr, Duke Human Vaccine Inst, Durham, NC 27706 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1525-4135
EI 1077-9450
J9 JAIDS-J ACQ IMM DEF
JI JAIDS
PD NOV
PY 2014
VL 67
SU 3
MA E-102
BP 59
EP 59
PG 1
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA CH6BF
UT WOS:000354119800045
ER
PT J
AU Hughes, L
Hamm, T
Crawford, K
Lenneman, T
Kibuuka, H
Maswai, J
Clinkscales, J
Robb, M
Michael, N
AF Hughes, Lindsay
Hamm, Tiffany
Crawford, Keith
Lenneman, Tessa
Kibuuka, Hannah
Maswai, Jonah
Clinkscales, Jessica
Robb, Merlin
Michael, Nelson
TI Assessing quality of HIV treatment in the United States Military HIV
Research Program/President's Emergency Plan for AIDS Relief
(PEPFAR)-supported programs in Africa
SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
LA English
DT Meeting Abstract
CT 16th Annual International Meeting of the Institute-of-Human-Virology
(IHV)
CY SEP 14-14, 2014
CL Univ Maryland Sch Med, Baltimore, MD
SP Inst Human Virol
HO Univ Maryland Sch Med
C1 [Hughes, Lindsay; Hamm, Tiffany; Clinkscales, Jessica; Robb, Merlin; Michael, Nelson] US Mil HIV Res Program, Walter Reed Army Inst Res, Silver Spring, MD USA.
[Hughes, Lindsay; Hamm, Tiffany; Crawford, Keith; Clinkscales, Jessica] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
[Crawford, Keith] US Mil HIV Res Program, Silver Spring, MD USA.
[Crawford, Keith] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Lenneman, Tessa] Hosp Univ Munich, Dept Infect Dis & Trop Med, Munich, Germany.
[Kibuuka, Hannah] Makerere Univ, Walter Reed Project, Kampala, Uganda.
[Maswai, Jonah] Walter Reed Project Kenya, Kericho, Kenya.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1525-4135
EI 1077-9450
J9 JAIDS-J ACQ IMM DEF
JI JAIDS
PD NOV
PY 2014
VL 67
SU 3
MA P-A12
BP 81
EP 81
PG 1
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA CH6BF
UT WOS:000354119800084
ER
PT J
AU Kota, KP
Soloveva, V
Wanner, LM
Gomba, G
Kiris, E
Panchal, RG
Kane, CD
Bavari, S
AF Kota, Krishna P.
Soloveva, Veronica
Wanner, Laura M.
Gomba, Glenn
Kiris, Erkan
Panchal, Rekha G.
Kane, Christopher D.
Bavari, Sina
TI A High Content Imaging Assay for Identification of Botulinum Neurotoxin
Inhibitors
SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
LA English
DT Article
DE Neuroscience; Issue 93; neuroscience; neurobiology; Botulinum
neurotoxin; Clostridium botulinum; high content imaging system;
neurotoxicity
ID SEROTYPE
AB Synaptosomal-associated protein-25 (SNAP-25) is a component of the soluble NSF attachment protein receptor (SNARE) complex that is essential for synaptic neurotransmitter release. Botulinum neurotoxin serotype A (BoNT/A) is a zinc metalloprotease that blocks exocytosis of neurotransmitter by cleaving the SNAP-25 component of the SNARE complex. Currently there are no licensed medicines to treat BoNT/A poisoning after internalization of the toxin by motor neurons. The development of effective therapeutic measures to counter BoNT/A intoxication has been limited, due in part to the lack of robust high-throughput assays for screening small molecule libraries. Here we describe a high content imaging (HCI) assay with utility for identification of BoNT/A inhibitors. Initial optimization efforts focused on improving the reproducibility of inter-plate results across multiple, independent experiments. Automation of immunostaining, image acquisition, and image analysis were found to increase assay consistency and minimize variability while enabling the multiparameter evaluation of experimental compounds in a murine motor neuron system.
C1 [Kota, Krishna P.] Perkin Elmer Inc, Waltham, MA 02451 USA.
[Soloveva, Veronica; Kane, Christopher D.] Henry M Jackson Fdn, Bethesda, MD USA.
[Wanner, Laura M.; Kiris, Erkan] Geneva Fdn, Tacoma, WA USA.
[Gomba, Glenn] ORISE, Oak Ridge, TN USA.
[Kiris, Erkan] Frederick Natl Lab Canc Res, Frederick, MD USA.
[Kota, Krishna P.; Soloveva, Veronica; Wanner, Laura M.; Gomba, Glenn; Kiris, Erkan; Panchal, Rekha G.; Kane, Christopher D.; Bavari, Sina] US Army Med Res Inst Infect Dis, Div Mol & Translat Sci, Frederick, MD USA.
[Soloveva, Veronica; Kane, Christopher D.] USAMRMC, TATRC, DoD Biotechnol High Performance Comp Software App, Frederick, MD USA.
RP Kota, KP (reprint author), Perkin Elmer Inc, Waltham, MA 02451 USA.
EM krishna.p.kota.ctr@mail.mil
FU Joint Science and Technology Office - Chemical Biological Defense
(JSTO-CBD) Defense Threat Reduction Agency (DTRA) [CB3675]; National
Institutes of Health [1 R21 AI101387-01, 5 U01AI082051-05]
FX Funding was provided by the Joint Science and Technology Office -
Chemical Biological Defense (JSTO-CBD) Defense Threat Reduction Agency
(DTRA) under sponsor project number CCAR# CB3675 and National Institutes
of Health (1 R21 AI101387-01 and 5 U01AI082051-05).
NR 14
TC 2
Z9 2
U1 1
U2 3
PU JOURNAL OF VISUALIZED EXPERIMENTS
PI CAMBRIDGE
PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA
SN 1940-087X
J9 JOVE-J VIS EXP
JI J. Vis. Exp.
PD NOV
PY 2014
IS 93
AR e51915
DI 10.3791/51915
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CB0JH
UT WOS:000349311400022
PM 25489815
ER
PT J
AU Montain, S
Jonas, WB
AF Montain, Scott
Jonas, Wayne B.
TI Nutritional Armor: Omega-3 for the Warfighter
SO MILITARY MEDICINE
LA English
DT Editorial Material
C1 [Montain, Scott] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA.
[Jonas, Wayne B.] Samueli Inst, Alexandria, VA 22314 USA.
RP Montain, S (reprint author), US Army Res Inst Environm Med, Mil Nutr Div, Bldg 42,Kansas St, Natick, MA 01760 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD NOV
PY 2014
VL 179
IS 11
SU S
BP 1
EP 1
DI 10.7205/MILMED-D-14-00452
PG 1
WC Medicine, General & Internal
SC General & Internal Medicine
GA CA7LS
UT WOS:000349099400001
PM 25373086
ER
PT J
AU Washington, MA
AF Washington, Michael A.
TI Melanized Fungi and Military Medical Operations in the Nuclear
Environment
SO MILITARY MEDICINE
LA English
DT Editorial Material
ID INFECTIONS
C1 Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA.
RP Washington, MA (reprint author), Tripler Army Med Ctr, Dept Clin Invest, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
NR 16
TC 0
Z9 0
U1 1
U2 4
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD NOV
PY 2014
VL 179
IS 11
BP 1181
EP 1183
DI 10.7205/MILMED-D-14-00152
PG 3
WC Medicine, General & Internal
SC General & Internal Medicine
GA CA7LK
UT WOS:000349098600007
PM 25373038
ER
PT J
AU Melanson, VR
Scheirer, JL
Van de Wyngaerde, MT
Bourzac, K
Wu, SJ
Kochel, T
McAvin, JC
AF Melanson, Vanessa R.
Scheirer, Jessica L.
Van de Wyngaerde, Marshall T.
Bourzac, Kevin
Wu, Shuenn-Jue
Kochel, Tadeusz
McAvin, James C.
TI Leveraging Arthropod-Borne Disease Surveillance Assays for Clinical
Diagnostic Use
SO MILITARY MEDICINE
LA English
DT Article
ID DENGUE VIRUS; IDENTIFICATION
AB Researchers at the Walter Reed Army Institute of Research have taken a joint service approach to filling an identified diagnostic capability gap by leveraging a vector surveillance assay. Specifically, the Army took a field-stable real-time polymerase chain reaction assay, developed by the Air Force, for dengue virus surveillance in arthropod vectors and collaborated with Navy researchers for utility in human diagnostics. As current Department of Defense diagnostic PCR assays employ the Joint Biological Agent Identification and Diagnostic System, the dengue assay was tested for use on this platform. The low rates of false negative and false positive dengue samples in clinical matrices demonstrate excellent utility as a human diagnostic assay. Overall, converting an arboviral vector surveillance assay to human diagnostic assay and potentially vice versa is both cost effective and labor reducing. Codevelopment with harmonization of vector surveillance and diagnostics offers monetary and resource advantages to the Department of Defense and should be considered as a path forward in times when downsizing threatens assay development and pathogen discovery.
C1 [Melanson, Vanessa R.; Scheirer, Jessica L.; Van de Wyngaerde, Marshall T.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
[Bourzac, Kevin] BioFire Diagnost Inc, Salt Lake City, UT 84108 USA.
[Wu, Shuenn-Jue; Kochel, Tadeusz] Navy Med Res Ctr, Silver Spring, MD 20910 USA.
[McAvin, James C.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
RP Melanson, VR (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
FU Military Infectious Disease Research Program (MIDRP), Program Area L
[L0245_12_WR]
FX We thank Tobin Rowland for providing us with his knowledge and insectary
support and Dr. Warren V. Kalina and Michael C. Yarnell for assistance
provided in peer review. The study was funded by the Military Infectious
Disease Research Program (MIDRP), Program Area L (L0245_12_WR), and
conducted through a Walter Reed Army Institute of Research/BioFire
Diagnostics Cooperative Research and Development Agreement.
NR 15
TC 0
Z9 0
U1 0
U2 1
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD NOV
PY 2014
VL 179
IS 11
BP 1207
EP 1211
DI 10.7205/MILMED-D-14-00019
PG 5
WC Medicine, General & Internal
SC General & Internal Medicine
GA CA7LK
UT WOS:000349098600011
PM 25373042
ER
PT J
AU Ciuffreda, KJ
Ludlam, DP
Thiagarajan, P
Yadav, NK
Capo-Aponte, J
AF Ciuffreda, Kenneth J.
Ludlam, Diana P.
Thiagarajan, Preethi
Yadav, Naveen K.
Capo-Aponte, Jose
TI Proposed Objective Visual System Biomarkers for Mild Traumatic Brain
Injury
SO MILITARY MEDICINE
LA English
DT Article
ID OCULOMOTOR REHABILITATION; EVOKED POTENTIALS; PROTOCOL; MTBI;
DYSFUNCTIONS; POPULATION; CONCUSSION; TRACKING; TBI; VEP
AB The challenge and search for objectively based biomarkers to assess for the presence of concussion/mild traumatic brain injury is a high priority for the military establishment. We present a documented overview of specific test areas and related targeted, high-yield, objectively based parameters that may be potential "vision biomarkers" for the detection of concussion/mild traumatic brain injury based on results from our laboratory and others, with emphasis on oculomotor aspects. These findings have military relevance with respect to the initial diagnosis in the battlefield and in the far-forward medical facilities, pre-/postdeployment issues, pre-/postvisual rehabilitation evaluation, fitness-for-duty assessment, and establishment of a return-to-duty timeline.
C1 [Ciuffreda, Kenneth J.; Ludlam, Diana P.; Thiagarajan, Preethi; Yadav, Naveen K.] SUNY State Coll Optometry, Dept Biol & Vis Sci, New York, NY 10036 USA.
[Capo-Aponte, Jose] Womack Army Med Ctr, Dept Optometry, Ft Bragg, NC 28310 USA.
RP Ciuffreda, KJ (reprint author), SUNY State Coll Optometry, Dept Biol & Vis Sci, 33 West 42nd St, New York, NY 10036 USA.
FU Department of Defense (DoD) [W81XWH-12-1-0240, W81XWH-10-1-0141];
Langeloth Foundation; College of Optometrists in Vision Development
(COVD); William C. Ezell Fellowship
FX We thank LTC James Truong for his helpful comments during manuscript
preparation. Our studies were supported from the following sources:
Department of Defense (DoD grants (W81XWH-12-1-0240 and
W81XWH-10-1-0141), Langeloth Foundation, College of Optometrists in
Vision Development (COVD), and the William C. Ezell Fellowship.
NR 49
TC 5
Z9 5
U1 0
U2 9
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD NOV
PY 2014
VL 179
IS 11
BP 1212
EP 1217
DI 10.7205/MILMED-D-14-00059
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA CA7LK
UT WOS:000349098600012
PM 25373043
ER
PT J
AU Nadler, R
Gendler, S
Chen, J
Lending, G
Abramovitch, A
Glassberg, E
AF Nadler, Roy
Gendler, Sami
Chen, Jacob
Lending, Gadi
Abramovitch, Amir
Glassberg, Elon
TI The Israeli Defense Force Experience With Intraosseous Access
SO MILITARY MEDICINE
LA English
DT Article
ID INFUSION; SERVICE; DEVICES; EMS
AB Introduction: Obtaining vascular access is of paramount importance in trauma care. When peripheral venous access is indicated but cannot be obtained, the intraosseous route represents an alternative. The Bone Injection Gun (BIG) is the device used for intraosseous access by the Israeli Defense Force (IDF). The purpose of this study is to assess the success rate of intraosseous access using this device. Method: The IDF Trauma Registry from 1999 to 2012 was searched for patients for whom at least 1 attempt at intraosseous access was made. Results: 37 attempts at intraosseous access were identified in 30 patients. Overall success rate was 50%. No differences in success rates were identified between different care givers. Overall mortality was 87%. Conclusion: The use of BIG in the IDF was associated with a low success rate at obtaining intraosseous access. Although inability to achieve peripheral venous access can be considered an indicator for poor prognosis, the high mortality rate for patients treated with BIG can also stand for the provider's low confidence in using this tool, making its use a last resort. This study serves as an example to ongoing learning process that includes data collection, analysis, and improvement, constantly taking place in the IDF.
C1 [Nadler, Roy; Gendler, Sami; Chen, Jacob; Lending, Gadi; Abramovitch, Amir; Glassberg, Elon] Israel Def Forces, Surg Gen HQ, Trauma & Combat Med Branch, IL-5262000 Ramat Gan, Israel.
[Chen, Jacob] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
RP Nadler, R (reprint author), Israel Def Forces, Surg Gen HQ, Trauma & Combat Med Branch, Yaakov Dori Rd, IL-5262000 Ramat Gan, Israel.
NR 15
TC 2
Z9 2
U1 0
U2 1
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD NOV
PY 2014
VL 179
IS 11
BP 1254
EP 1257
DI 10.7205/MILMED-D-1400013
PG 4
WC Medicine, General & Internal
SC General & Internal Medicine
GA CA7LK
UT WOS:000349098600019
PM 25373050
ER
PT J
AU Tubb, CC
Oh, JS
Do, NV
Tai, NR
Meissel, MP
Place, ML
AF Tubb, Creighton C.
Oh, John S.
Do, Nhan V.
Tai, Nigel R.
Meissel, Michael P.
Place, Michael L.
TI Trauma Care at a Multinational United Kingdom-Led Role 3 Combat
Hospital: Resuscitation Outcomes From a Multidisciplinary Approach
SO MILITARY MEDICINE
LA English
DT Article
ID MAJOR LIMB TRAUMA; LEVEL-I; MASSIVE TRANSFUSION; CASUALTIES; MORTALITY;
CENTERS; THEATER; INJURY; VOLUME; IRAQ
AB Recent conflicts have led significant advancements in casualty care. Facilities serving combat wounded operate in challenging environments. Our purpose is to describe the multidisciplinary resuscitation algorithm utilized at a United Kingdom-led, Role 3 multinational treatment facility in Afghanistan focusing on injury severity and in-hospital mortality. Methods: Data were extracted from our prospectively collected trauma registry on military members wounded in action. Results: From November 1, 2009 to September 30, 2011, there were 3483 military trauma admissions. Common mechanisms of injury were improvised explosive devices (48%), followed by gunshot wounds (29%). Most patients (83.1%) had an Injury Severity Score (ISS) <15. For patients with complete ISS data, 8.4% had massive transfusion and 6.1% had an initial base deficit >5. Patients admitted with signs of life had a died of wounds rate of 1.8% with an average 1.2 day hospital stay. The mortality rate for patients undergoing massive transfusion was 4.8%, and for patients with a base deficit >5, mortality was 12.3%. Severely injured patients (ISS > 24) had a mortality rate of 16.5%. Conclusion: A systematic, multidisciplinary approach to trauma is associated with low in-hospital mortality. The outcomes in this study serve as a measure for future care in Role 3 facilities.
C1 [Tubb, Creighton C.] San Antonio Mil Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA.
[Oh, John S.] Walter Reed Natl Mil Med Ctr, Dept Surg, Bethesda, MD 20889 USA.
[Do, Nhan V.] Clin Capabil Management, Falls Church, VA 22042 USA.
[Tai, Nigel R.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham B15 2SQ, W Midlands, England.
[Meissel, Michael P.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Place, Michael L.] Natl Def Univ, Eisenhower Sch, Arlington, VA 22204 USA.
RP Tubb, CC (reprint author), San Antonio Mil Med Ctr, Dept Orthopaed & Rehabil, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
NR 24
TC 1
Z9 1
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD NOV
PY 2014
VL 179
IS 11
BP 1258
EP 1262
DI 10.7205/MILMED-D-14-00042
PG 5
WC Medicine, General & Internal
SC General & Internal Medicine
GA CA7LK
UT WOS:000349098600020
PM 25373051
ER
PT J
AU Matthews, T
Abraham, J
Zacher, LL
Morris, MJ
AF Matthews, Tokunbo
Abraham, Joseph
Zacher, Lisa L.
Morris, Michael J.
TI The Impact of Deployment on COPD in Active Duty Military Personnel
SO MILITARY MEDICINE
LA English
DT Article
ID GULF-WAR VETERANS; KUWAIT OIL FIRES; RESPIRATORY SYMPTOMS; AFGHANISTAN;
EXPOSURE; ILLNESS; US
AB Purpose: To identify trends in chronic obstructive pulmonary disease (COPD) diagnoses among active duty U.S. military personnel based on deployment history and whether International Classification of Disease, 9th edition (ICD-9) coding meet criteria for the diagnosis of COPD. Methods: A retrospective chart review using the electronic medical system was conducted for military personnel diagnosed with COPD based on ICD-9 codes for emphysema or chronic obstructive lung disease with at least three qualifying outpatient COPD-coded encounters. Clinical symptoms, smoking history, pulmonary function testing, and radiographs obtained during the diagnostic workup were reviewed. The established diagnosis of COPD was analyzed in relation to deployment. Results: A total of 371 patients were identified during the study period (2005-2009). Of these patients, 194 (52.3%) deployed, whereas 177 (47.7%) did not deploy to Southwest Asia since 2003. Thirty-four percent had no documented smoking history despite the diagnosis of COPD. Airway obstruction was identified by spirometry in only 67% of individuals diagnosed with COPD. No statistically significant differences in pulmonary function testing values were identified between those deployed and nondeployed individuals. Conclusion: Despite evidence of increased respiratory symptoms in deployed military personnel, the impact of deployment on increased diagnosis of COPD or severity of disease appears minimal.
C1 [Matthews, Tokunbo] Joint Base Elmendorf Richardson Hosp, Pulm Dis Serv, Jber, AK 99506 USA.
[Matthews, Tokunbo] US Army Publ Hlth Command, Aberdeen Proving Ground, MD 21010 USA.
[Zacher, Lisa L.] Orlando Vet Adm Hosp, Dept Med, Orlando, FL 32803 USA.
[Morris, Michael J.] San Antonio Mil Med Ctr, Pulm Crit Care Serv, Dept Med, Ft Sam Houston, TX 78234 USA.
RP Matthews, T (reprint author), Joint Base Elmendorf Richardson Hosp, Pulm Dis Serv, 5955 Zeamer Ave, Jber, AK 99506 USA.
NR 12
TC 1
Z9 1
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD NOV
PY 2014
VL 179
IS 11
BP 1273
EP 1278
DI 10.7205/MILMED-D-14-00066
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA CA7LK
UT WOS:000349098600023
PM 25373054
ER
PT J
AU Gehrich, AP
Patzwald, JR
Kern, ME
Squires, CC
Lustik, MB
AF Gehrich, Alan P.
Patzwald, Jason R.
Kern, Molly E.
Squires, Chris C.
Lustik, Michael B.
TI The Incidence of Early and Recurrent Urinary Tract Infections After
Midurethral Sling Operations
SO MILITARY MEDICINE
LA English
DT Article
ID RANDOMIZED CONTROLLED-TRIAL; ANTIBIOTIC-PROPHYLAXIS; INCONTINENCE
SURGERY; STRESS-INCONTINENCE; WOMEN; COMPLICATIONS; RISK
AB Objective: To define the incidence of early and recurrent urinary tract infections (RUTIs) in the 12-month postoperative period following midurethral sling (MUS) operations and evaluate for risk factors. Methods: This retrospective chart review compiled all urine analyses and urine culture results within 12 months of MUS surgery on all patients in the years 2006-2012 for which data were available. All coincident risk factors were tabulated. Statistical analysis was performed using SAS v 9.2 (SAS Institute, Cary, North Carolina). Results: 141 MUS procedures were performed in the 6-year time frame utilizing standard antibiotic prophylaxis regimens. 133 had adequate data for analysis. 10 patients (7.5% confidence intervals [CI] [3.7-12.4]) developed an acute UTI in the first 8 weeks postoperatively. 3 of 121 patients (2.3% CI [0.5-5.9]) developed RUTIs in the first year following surgery. Bivariate and multiple logistic regression analyses of the data did not reveal any risk factors for either isolated postoperative UTIs or RUTIs. Conclusions: This study documents a low incidence of both acute and RUTIs in the female population undergoing MUS operations. These results support the current recommendations for perioperative prophylactic antibiotics for anti-incontinence procedures.
C1 [Gehrich, Alan P.; Patzwald, Jason R.; Kern, Molly E.; Squires, Chris C.; Lustik, Michael B.] Tripler Army Med Ctr, Dept Obstet & Gynecol, Honolulu, HI 96859 USA.
[Lustik, Michael B.] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA.
RP Gehrich, AP (reprint author), Tripler Army Med Ctr, Dept Obstet & Gynecol, Honolulu, HI 96859 USA.
NR 19
TC 2
Z9 2
U1 1
U2 2
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD NOV
PY 2014
VL 179
IS 11
BP 1301
EP 1306
DI 10.7205/MILMED-D-14-00122
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA CA7LK
UT WOS:000349098600027
PM 25373058
ER
PT J
AU Bedno, S
Hauret, K
Loringer, K
Kao, TC
Mallon, T
Jones, B
AF Bedno, Sheryl
Hauret, Keith
Loringer, Kelly
Kao, Tzu-Cheg
Mallon, Timothy
Jones, Bruce
TI Effects of Personal and Occupational Stress on Injuries in a Young,
Physically Active Population: A Survey of Military Personnel
SO MILITARY MEDICINE
LA English
DT Article
ID EXERCISE-RELATED INJURIES; FORCE SAFETY CENTER; FEMALE ARMY TRAINEES;
LIMITED-DUTY DAYS; RISK-FACTORS; MUSCULOSKELETAL INJURIES; SPORTS
INJURIES; PREVENTION; WORK; RECOMMENDATIONS
AB The aim of this study was to document risk factors for any injury and sports- and exercise-related injuries, including personal and occupational stress among active duty service members (SMs) in the Air Force, Army, Marine Corps, and Navy. A total of 10,692 SMs completed the April 2008 Status of Forces Survey of Active Duty Members. The survey asked about demographics, personal stress and occupational stress, injuries from any cause, and participation in sports-and exercise-related activities in the past year. The survey used a complex sampling procedure to create a representative sample of SMs. Logistic regression was used to examine the associations of injury outcomes with potential risk factors. 49% of SMs sought medical care for an injury in the past year and 25% sustained a sports-and exercise-related activities injury. Odds of injury were higher for the Army and Marine Corps than for the Air Force or Navy. This survey showed that higher personal and occupational stress was associated with higher risks of injury. SMs who experienced higher levels of personal or occupational stress reported higher risks of injuries. The effects of stress reduction programs on injury risks should be evaluated in military and other young physically active populations.
C1 [Bedno, Sheryl] William Beaumont Army Med Ctr, Dept Clin Invest, El Paso, TX 79920 USA.
[Hauret, Keith; Jones, Bruce] US Army Publ Hlth Command, Aberdeen Proving Ground, MD 21010 USA.
[Loringer, Kelly] 28th Med Grp, Ellsworth AFB, SD 57706 USA.
[Kao, Tzu-Cheg; Mallon, Timothy] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA.
RP Bedno, S (reprint author), William Beaumont Army Med Ctr, Dept Clin Invest, 5005 Piedras, El Paso, TX 79920 USA.
FU Uniformed Services University of the Health Sciences [CO874F]
FX This study received an intramural grant (CO874F) from the Uniformed
Services University of the Health Sciences.
NR 47
TC 1
Z9 1
U1 0
U2 3
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD NOV
PY 2014
VL 179
IS 11
BP 1311
EP 1318
DI 10.7205/MILMED-D-14-00080
PG 8
WC Medicine, General & Internal
SC General & Internal Medicine
GA CA7LK
UT WOS:000349098600029
PM 25373060
ER
PT J
AU Spooner, SP
Tyner, SD
Sowers, C
Tsao, J
Stuessi, K
AF Spooner, Shawn P.
Tyner, Stuart D.
Sowers, Christopher
Tsao, Jack
Stuessi, Keith
TI Utility of a Sports Medicine Model in Military Combat Concussion and
Musculoskeletal Restoration Care
SO MILITARY MEDICINE
LA English
DT Article
ID OPERATION-IRAQI-FREEDOM; INJURY; RETURN; DUTY; WAR
AB Combat-related concussions are significant sources of injury and morbidity among deployed military service members. Musculoskeletal injury also is one of the most prevalent battle and nonbattle-related deployed injury types. Both injuries threaten the service member's physical condition as well as unit and mission readiness due to reduced duty status or evacuation from military theater of operations. In August 2010, the Concussion Restoration Care Center (CRCC) was established at Camp Leatherneck, Afghanistan, to address the need for consistent and specialized evaluation and care of concussion and musculoskeletal injury. This performance improvement effort examined evaluation and treatment of concussion and musculoskeletal injury at the CRCC. Among 4,947 military personnel evaluated at the CRCC between August 2010 and May 2013, 97.9% were returned to duty and retained in theater. Members averaged 10 to 12 days of limited duty status to achieve complete recovery. Concussion injury was secondary to blast injury in 90% of cases. Sport/recreation, occupational, and other accidental injuries each represented 30% of the musculoskeletal injuries with only 10% reported as result of combat. The utilization patterns and outcome measures demonstrate the success and utility of a multidisciplinary clinical model of care for these two types of injuries in the far-forward deployed setting.
C1 [Spooner, Shawn P.] Captain James A Lovell Fed Healthcare Ctr, N Chicago, IL 60064 USA.
[Spooner, Shawn P.] Unity Point Clin, Des Moines, IA 50322 USA.
[Spooner, Shawn P.] Unity Point Clin Sports Med Urbandale, Urbandale, IA 50322 USA.
[Tyner, Stuart D.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Stuessi, Keith] Naval Hosp Camp Pendleton, Camp Pendleton, CA 92055 USA.
[Tsao, Jack] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
RP Spooner, SP (reprint author), Captain James A Lovell Fed Healthcare Ctr, 3001 Green Bay Rd, N Chicago, IL 60064 USA.
NR 12
TC 0
Z9 0
U1 0
U2 1
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD NOV
PY 2014
VL 179
IS 11
BP 1319
EP 1324
DI 10.7205/MILMED-D-14-00191
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA CA7LK
UT WOS:000349098600030
PM 25373061
ER
PT J
AU Jones, RS
Simmons, A
Boykin, GL
Stamper, D
Thompson, JC
AF Jones, Robert S.
Simmons, Angela
Boykin, Gary L., Sr.
Stamper, David
Thompson, Jennifer C.
TI Measuring Intravenous Cannulation Skills of Practical Nursing Students
Using Rubber Mannequin Intravenous Training Arms
SO MILITARY MEDICINE
LA English
DT Article
ID SIMULATION
AB This study examined the effectiveness of two training methods for peripheral intravenous (IV) cannulation; one using rubber mannequin IV training arms, and the other consisting of students performing the procedure on each other. Two hundred-sixty Phase II Army Practical Nursing students were randomized into two groups and trained to perform an IV cannulation procedure. All students watched a 12-minute training video covering standard IV placement procedures. Afterward, both groups practiced the procedure for an hour according to their assigned group. Students were then tested on IV placement in a live human arm using a 14-item testing instrument in three trials that were scored pass/fail. There was no difference in the groups' performance of the IV procedure on the first attempt: 51.7% (n = 92) of the human arm group passed the test, and 48.3% (n = 86) of the rubber mannequin group passed the test (p = 0.074). These data suggest that using rubber mannequin IV arms for IV skills training may be just as effective as training students using traditional methods. In addition, using simulation provides an extra benefit of reducing risks associated with learning the procedure on a fellow student.
C1 [Jones, Robert S.] Army Med Dept Ctr & Sch, Dept Nursing Sci, Ft Sam Houston, TX 78234 USA.
[Simmons, Angela] Brooke Army Med Ctr, Ctr Nursing Sci & Clin Inquiry, Ft Sam Houston, TX 78234 USA.
[Boykin, Gary L., Sr.] US Army Res Lab, AMEDD, Ft Sam Houston, TX 78234 USA.
[Stamper, David] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
[Thompson, Jennifer C.] Orlando VA Med Ctr, Orlando, FL 32803 USA.
RP Jones, RS (reprint author), Army Med Dept Ctr & Sch, Dept Nursing Sci, 3490 Forage Rd, Ft Sam Houston, TX 78234 USA.
NR 17
TC 2
Z9 2
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD NOV
PY 2014
VL 179
IS 11
BP 1361
EP 1367
DI 10.7205/MILMED-D-13-00576
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA CA7LK
UT WOS:000349098600036
PM 25373067
ER
PT J
AU Cranor, LF
Buchler, N
AF Cranor, Lorrie Faith
Buchler, Norbou
TI Better Together: Usability and Security Go Hand in Hand
SO IEEE SECURITY & PRIVACY
LA English
DT Article
C1 [Cranor, Lorrie Faith] Carnegie Mellon Univ, Pittsburgh, PA 15213 USA.
[Buchler, Norbou] US Army Res Lab, Human Res & Engn Directorate, Washington, DC USA.
RP Cranor, LF (reprint author), Carnegie Mellon Univ, Pittsburgh, PA 15213 USA.
EM lorrie@acm.org; norbou.buchler.civ@mail.mil
OI Cranor, Lorrie/0000-0003-2125-0124
NR 17
TC 0
Z9 0
U1 2
U2 5
PU IEEE COMPUTER SOC
PI LOS ALAMITOS
PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA
SN 1540-7993
EI 1558-4046
J9 IEEE SECUR PRIV
JI IEEE Secur. Priv.
PD NOV-DEC
PY 2014
VL 12
IS 6
BP 89
EP 93
PG 5
WC Computer Science, Information Systems; Computer Science, Software
Engineering
SC Computer Science
GA AZ2JC
UT WOS:000348059000015
ER
PT J
AU Apland, JP
Aroniadou-Anderjaska, V
Figueiredo, TH
Rossetti, F
Miller, SL
Braga, MFM
AF Apland, James P.
Aroniadou-Anderjaska, Vassiliki
Figueiredo, Taiza H.
Rossetti, Franco
Miller, Steven L.
Braga, Maria F. M.
TI The Limitations of Diazepam as a Treatment for Nerve Agent-Induced
Seizures and Neuropathology in Rats: Comparison with UBP302
SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
LA English
DT Article
ID REFRACTORY STATUS EPILEPTICUS; RECEPTOR ANTAGONIST LY293558;
SOMAN-INDUCED SEIZURES; ANXIETY-LIKE BEHAVIOR; BASOLATERAL AMYGDALA;
GABA(A) RECEPTORS; KAINATE RECEPTORS; PILOCARPINE MODEL; FOLLOW-UP;
HIPPOCAMPUS
AB Exposure to nerve agents induces prolonged status epilepticus (SE), causing brain damage or death. Diazepam (DZP) is the current US Food and Drug Administration-approved drug for the cessation of nerve agent-induced SE. Here, we compared the efficacy of DZP with that of UBP302 [(S)-3-(2-carboxybenzyl) willardiine; an antagonist of the kainate receptors that contain the GluK1 subunit] against seizures, neuropathology, and behavioral deficits induced by soman in rats. DZP, administered 1 hour or 2 hours postexposure, terminated the SE, but seizures returned; thus, the total duration of SE within 24 hours after soman exposure was similar to (DZP at 1 hour) or longer than (DZP at 2 hours) that in the soman-exposed rats that did not receive the anticonvulsant. Compared with DZP, UBP302 stopped SE with a slower time course, but dramatically reduced the total duration of SE within 24 hours. Neuropathology and behavior were assessed in the groups that received anticonvulsant treatment 1 hour after exposure. UBP302, but not DZP, reduced neuronal degeneration in a number of brain regions, as well as neuronal loss in the basolateral amygdala and the CA1 hippocampal area, and prevented interneuronal loss in the basolateral amygdala. Anxiety-like behavior was assessed in the open field and by the acoustic startle response 30 days after soman exposure. The results showed that anxiety-like behavior was increased in the DZP-treated group and in the group that did not receive anticonvulsant treatment, but not in the UBP302-treated group. The results argue against the use of DZP for the treatment of nerve agent-induced seizures and brain damage and suggest that targeting GluK1-containing receptors is a more effective approach.
C1 [Apland, James P.] US Army, Med Res Inst Chem Def, Neurotoxicol Branch, Aberdeen Proving Ground, MD 21010 USA.
[Aroniadou-Anderjaska, Vassiliki; Figueiredo, Taiza H.; Miller, Steven L.; Braga, Maria F. M.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Anat Physiol & Genet, Bethesda, MD 20814 USA.
[Aroniadou-Anderjaska, Vassiliki; Braga, Maria F. M.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Psychiat, Bethesda, MD 20814 USA.
RP Braga, MFM (reprint author), Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Anat Physiol & Genet, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
EM maria.braga@usuhs.edu
OI Miller, Steven/0000-0002-2061-8188
FU National Institutes of Health Office of the Director; National
Institutes of Health National Institute of Neurologic Disorders and
Stroke CounterACT Program [5U01-NS058162-07]
FX This work was supported by the National Institutes of Health Office of
the Director and the National Institutes of Health National Institute of
Neurologic Disorders and Stroke CounterACT Program [Grant
5U01-NS058162-07]. The views expressed in this article are those of the
authors and do not reflect the official policy of the Department of the
Army, the Department of Defense, or the US Government.
NR 64
TC 10
Z9 10
U1 0
U2 8
PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA
SN 0022-3565
EI 1521-0103
J9 J PHARMACOL EXP THER
JI J. Pharmacol. Exp. Ther.
PD NOV
PY 2014
VL 351
IS 2
BP 359
EP 372
DI 10.1124/jpet.114.217299
PG 14
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA CA2LK
UT WOS:000348739800005
PM 25157087
ER
PT J
AU West, JC
Wilk, JE
Duffy, FF
Kuramoto, SJ
Rae, DS
Moscicki, EK
Hoge, CW
AF West, Joyce C.
Wilk, Joshua E.
Duffy, Farifteh F.
Kuramoto, S. Janet
Rae, Donald S.
Moscicki, Eve K.
Hoge, Charles W.
TI Mental Health Treatment Access and Quality in the Army: Survey of Mental
Health Clinicians
SO JOURNAL OF PSYCHIATRIC PRACTICE
LA English
DT Article
DE mental health; substance abuse; access; quality; military
ID RATES; IRAQ
AB Objective. The goal of this study was to identify factors affecting timely, quality mental health and substance abuse treatment for service members and characterize patients at the greatest risk of having problems accessing treatment. Methods. An electronic survey was emailed to 2,310 Army mental healthcare providers. After providers with undeliverable emails and who self-reported not being behavioral health providers were excluded, 543 (26%) of the remaining 2,104 providers responded. This represented approximately a quarter of all Army behavioral health providers at the time of the survey. Of these 543 providers, 399 (73%) reported treating at least one service member during their last typical work week and provided clinically detailed data on one systematically selected service member. Results. The majority of the clinicians reported being able to spend sufficient time with patients (91.8%) and schedule encounters to meet patients' needs (82.4%). The clinicians also identified services where treatment access was more limited and patient subgroups with an unmet need for additional clinical care or services. Specifically, a significant proportion of clinicians reported that they were "never, rarely, or sometimes" able to provide or arrange for mental health treatment for the sampled service member's children (52.0%), provide or arrange for marriage and family therapy (40.1%), coordinate care effectively with primary care (36.7%), provide or arrange for care/case management (28.3%), or provide or arrange for substance abuse treatment (24.9%). Patients with more severe symptoms and diagnostic and clinical complexity had higher rates of problems with treatment access. Conclusions. Our findings highlight opportunities to improve access to timely, quality treatment for service members and their families.
C1 [West, Joyce C.; Duffy, Farifteh F.; Kuramoto, S. Janet; Rae, Donald S.; Moscicki, Eve K.] Amer Psychiat Inst Res & Educ, Arlington, VA USA.
[Wilk, Joshua E.; Hoge, Charles W.] Walter Reed Army Inst Res, Dept Mil Psychiat, Ctr Mil Psychiat & Neurosci Res, Silver Spring, MD USA.
RP West, JC (reprint author), Amer Psychiat Fdn, Amer Psychiat Inst Res & Educ, 1000 Wilson Blvd,Suite 1825, Arlington, VA 22209 USA.
EM Jwest@psych.org
FU Walter Reed Army Institute of Research; Army Office of the Surgeon
General
FX Acknowledgements: This study was funded by the Walter Reed Army
Institute of Research. We thank the U.S. Army behavioral health
providers and the Army Office of the Surgeon General for their support
and participation in this study and for their service to our nation. We
thank the Mountain West Research Center for their work in developing the
on-line survey.
NR 20
TC 2
Z9 2
U1 1
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-4160
EI 1538-1145
J9 J PSYCHIATR PRACT
JI J. Psychiatr. Pract.
PD NOV
PY 2014
VL 20
IS 6
BP 448
EP 459
DI 10.1097/01.pra.0000456593.58739.61
PG 12
WC Psychiatry
SC Psychiatry
GA CA0CR
UT WOS:000348583000005
PM 25406049
ER
PT J
AU Ivashchenko, VI
Scrynskyy, PL
Lytvyn, OS
Butenko, OO
Sinelnichenko, OK
Gorb, L
Hill, F
Leszczynski, J
Kozak, AO
AF Ivashchenko, V. I.
Scrynskyy, P. L.
Lytvyn, O. S.
Butenko, O. O.
Sinelnichenko, O. K.
Gorb, L.
Hill, F.
Leszczynski, J.
Kozak, A. O.
TI Comparative investigation of NbN and Nb-Si-N films: Experiment and
theory
SO JOURNAL OF SUPERHARD MATERIALS
LA English
DT Article
DE NbN and Nb-Si-N films; magnetron sputtering; film structure; bonding
picture; nanoindentation; first-principles calculations; stress-strain
curves
ID NITRIDE THIN-FILMS; ARC-DEPOSITED NBN; MECHANICAL-PROPERTIES; MULTILAYER
COATINGS; MICROSTRUCTURE; MULTICOMPONENT; HARDNESS
AB NbN and Nb-Si-N films have been deposited by magnetron sputtering of the Nb and Si targets on silicon wafers at various powers supplied to the Nb target. The films have been investigated by an atomic force microscope, X-ray diffraction, X-ray photoelectron spectroscopy, nanoindentaion and microindentation. The NbN films were nanostructured, and the Nb-Si-N films represented an aggregation of delta-NbN (x) nanocrystallites embedded into the amorphous Si3N4 matrix (nc-delta-NbN (x) /a-Si3N4). The annealing of the films in vacuum showed that their intensive oxidation occurred at annealing temperature higher than 600A degrees C. To explain the experimental results on the Nb-Si-N films, first-principles molecular dynamics simulations of the NbN(001)/Si3N4 heterostructures have been carried out.
C1 [Ivashchenko, V. I.; Scrynskyy, P. L.; Butenko, O. O.; Sinelnichenko, O. K.; Kozak, A. O.] Natl Acad Sci Ukraine, Frantsevich Inst Mat Sci Problems, UA-03680 Kiev, Ukraine.
[Lytvyn, O. S.] Natl Acad Sci, Lashkarev Inst Phys Semicond, UA-03028 Kiev, Ukraine.
[Gorb, L.; Leszczynski, J.] Jackson State Univ, Interdisciplinary Ctr Nanotox, Jackson, MS 39217 USA.
[Gorb, L.] Badger Tech Serv LLC, Vicksburg, MS 39180 USA.
[Hill, F.] US Army, Erdc, Vicksburg, MS 39180 USA.
RP Ivashchenko, VI (reprint author), Natl Acad Sci Ukraine, Frantsevich Inst Mat Sci Problems, Vul Krzhizhanovskogo 3, UA-03680 Kiev, Ukraine.
EM ivash@ipms.kiev.ua
FU STCU [5539]; directorate of the Summery Institute at Jackson State
University
FX This work was partially supported by STCU Contract No. 5539. The authors
are grateful to Dr. Timofejeva and Dr. Dub for XRD investigations and
nanoindentation of the films. The authors are grateful to the
directorate of the Summery Institute at Jackson State University for
financial support and the possibility to perform large-scale
calculations.
NR 36
TC 2
Z9 2
U1 3
U2 20
PU ALLERTON PRESS INC
PI NEW YORK
PA 18 WEST 27TH ST, NEW YORK, NY 10001 USA
SN 1063-4576
EI 1934-9408
J9 J SUPERHARD MATER+
JI J. Superhard Mater.
PD NOV
PY 2014
VL 36
IS 6
BP 381
EP 392
DI 10.3103/S1063457614060033
PG 12
WC Materials Science, Multidisciplinary
SC Materials Science
GA AX4PI
UT WOS:000346913700003
ER
PT J
AU Vuyovich, CM
Jacobs, JM
Daly, SF
AF Vuyovich, Carrie M.
Jacobs, Jennifer M.
Daly, Steven F.
TI Comparison of passive microwave and modeled estimates of total watershed
SWE in the continental United States
SO WATER RESOURCES RESEARCH
LA English
DT Article
ID EQUIVALENT RETRIEVAL ALGORITHMS; NORTHERN GREAT-PLAINS; SNOW DEPTH;
WESTERN CANADA; IN-SITU; USA; UNCERTAINTY; AFGHANISTAN; RADIATION;
BASINS
AB In the U.S., a dedicated system of snow measurement stations and snowpack modeling products is available to estimate the snow water equivalent (SWE) throughout the winter season. In other regions of the world that depend on snowmelt for water resources, snow data can be scarce, and these regions are vulnerable to drought or flood conditions. Even in the U.S., water resource management is hampered by limited snow data in certain regions, as evident by the 2011 Missouri Basin flooding due in large part to the significant Plains snowpack. Satellite data could potentially provide important information in under-sampled areas. This study compared the daily AMSR-E and SSM/I SWE products over nine winter seasons to spatially distributed, modeled output SNODAS summed over 2100 watersheds in the conterminous U.S. Results show large areas where the passive microwave retrievals are highly correlated to the SNODAS data, particularly in the northern Great Plains and southern Rocky Mountain regions. However, the passive microwave SWE is significantly lower than SNODAS in heavily forested areas, and regions that typically receive a deep snowpack. The best correlations are associated with basins in which maximum annual SWE is less than 200 mm, and forest fraction is less than 20%. Even in many watersheds with poor correlations between the passive microwave data and SNODAS maximum annual SWE values, the overall pattern of accumulation and ablation did show good agreement and therefore may provide useful hydrologic information on melt timing and season length.
C1 [Vuyovich, Carrie M.; Daly, Steven F.] Cold Reg Res & Engn Lab, Hanover, NH 03755 USA.
[Jacobs, Jennifer M.] Univ New Hampshire, Dept Civil Engn, Durham, NH 03824 USA.
RP Vuyovich, CM (reprint author), Cold Reg Res & Engn Lab, Hanover, NH 03755 USA.
EM carrie.m.vuyovich@usace.army.mil
FU NASA EPSCoR [NNX11AQ34A]; University of New Hampshire; U.S. Army
Engineer Research and Development Center's Cold Regions Research and
Engineering Laboratory
FX This work was supported by a NASA EPSCoR grant NNX11AQ34A, the
University of New Hampshire and the U.S. Army Engineer Research and
Development Center's Cold Regions Research and Engineering Laboratory.
We are grateful to Jeff Neihaus for his assistance in obtaining archived
SNODAS data. We would like to thank Jeff Dozier, the associate editor,
and two anonymous reviewers for their valuable feedback. All data used
in this study are freely available and can be obtained by contacting the
corresponding author.
NR 52
TC 9
Z9 9
U1 1
U2 18
PU AMER GEOPHYSICAL UNION
PI WASHINGTON
PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA
SN 0043-1397
EI 1944-7973
J9 WATER RESOUR RES
JI Water Resour. Res.
PD NOV
PY 2014
VL 50
IS 11
BP 9088
EP 9102
DI 10.1002/2013WR014734
PG 15
WC Environmental Sciences; Limnology; Water Resources
SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water
Resources
GA AX0PQ
UT WOS:000346654600039
ER
PT J
AU Brunye, TT
Cantelon, J
Holmes, A
Taylor, HA
Mahoney, CR
AF Brunye, Tad T.
Cantelon, Julie
Holmes, Amanda
Taylor, Holly A.
Mahoney, Caroline R.
TI Mitigating Cutaneous Sensation Differences During tDCS: Comparing Sham
Versus Low Intensity Control Conditions
SO BRAIN STIMULATION
LA English
DT Article
DE Brain stimulation; Methodology; Cutaneous sensation; Inhibitory control
ID DIRECT-CURRENT STIMULATION; MULTISOURCE INTERFERENCE TASK; TRANSCRANIAL
DC STIMULATION; PREFRONTAL CORTEX; BRAIN-STIMULATION; MOTOR CORTEX;
PERCEPTION; FMRI; EXCITABILITY; BEHAVIOR
AB Background: Cutaneous sensations at electrode sites during the administration of direct current brain stimulation may inadvertently influence participants' subjective experience and task performance.
Objective: The present study evaluated the utility of a methodological variation that substitutes sham administration with very low intensity (0.5 mA) current delivery.
Methods: We used a 4 x 1 high-definition ring electrode transcranial direct current (HD-tDCS) system to target the left dorsolateral prefrontal cortex (Brodmann's Area 9). Four stimulation conditions were compared in a repeated-measures design: sham 2.0 mA and 0.5 mA intensity, versus active 2.0 mA and 0.5 mA intensity. During stimulation participants performed a cognitive interference task that activates the cingulo-frontal-parietal network, and periodically provided perceived sensation ratings.
Results: We demonstrate that a relatively low intensity control condition attenuates otherwise large differences in perceived sensation between active and sham conditions. Critically, behavioral task differences maintained between the two active conditions.
Conclusion: A low intensity control stimulation condition may prove a viable methodological alternative to conventional sham techniques used in repeated-measures designs, though important limitations are discussed. Published by Elsevier Inc.
C1 [Brunye, Tad T.; Cantelon, Julie; Holmes, Amanda; Mahoney, Caroline R.] US Army, NSRDEC, RDNS SEW THC, Natick, MA 01760 USA.
[Brunye, Tad T.; Cantelon, Julie; Holmes, Amanda; Taylor, Holly A.; Mahoney, Caroline R.] Tufts Univ, Dept Psychol, Medford, MA 02155 USA.
RP Brunye, TT (reprint author), US Army, NSRDEC, RDNS SEW THC, 15 Kansas St, Natick, MA 01760 USA.
EM tbruny01@tufts.edu
OI Brunye, Tad/0000-0002-8788-8764
NR 28
TC 4
Z9 4
U1 1
U2 8
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1935-861X
EI 1876-4754
J9 BRAIN STIMUL
JI Brain Stimul.
PD NOV-DEC
PY 2014
VL 7
IS 6
SI SI
BP 832
EP 835
DI 10.1016/j.brs.2014.09.015
PG 4
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA AW7OZ
UT WOS:000346455200010
PM 25444591
ER
PT J
AU Song, J
Han, XG
Gaskell, KJ
Xu, K
Lee, SB
Hu, LB
AF Song, Jaehee
Han, Xiaogang
Gaskell, Karen J.
Xu, Kang
Lee, Sang Bok
Hu, Liangbing
TI Enhanced electrochemical stability of high-voltage LiNi0.5Mn1.5O4
cathode by surface modification using atomic layer deposition
SO JOURNAL OF NANOPARTICLE RESEARCH
LA English
DT Article
DE Ultrathin coating Al2O3; Atomic layer deposition; LiNi0.5Mn1.5O4
nanoparticle; XPS investigation; Li-ion battery; Energy storage
ID LITHIUM-ION BATTERIES; THIN-FILM; SPINEL; LICOO2; TEMPERATURE;
PERFORMANCE; PROGRESS; CELLS; XPS
AB We report improved cycling performance of high-voltage LiNi0.5Mn1.5O4 cathode for lithium-ion batteries by modifying its surface with ultrathin layer coating of Al2O3 (<1 nm) using atomic layer deposition (ALD) technique. Four and six layers of ALD Al2O3 were coated directly on the porous LiNi0.5Mn1.5O4 nanoparticle (similar to 200 nm) slurry composite. Electrochemical characterization results show that LiNi0.5Mn1.5O4 electrode with four and six layers of ALD Al2O3 maintained 92 and 98 % of their initial capacity after 200 cycles, respectively, in comparison to bare LiNi0.5Mn1.5O4 electrode which showed 84 % capacity retention. We show that the ALD Al2O3 coated cathode surface is protected from undesired side reactions occurring at the electrode/electrolyte interface. For the first time, we used XPS studies to investigate the surface chemistry of ultrathin ALD Al2O3 coated LiNi0.5Mn1.5O4 and confirmed that the ultrathin ALD Al2O3 layer reduces side reactions involving organic components of the electrolyte decomposition product in high-voltage cathodes.
C1 [Song, Jaehee; Gaskell, Karen J.; Lee, Sang Bok] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA.
[Han, Xiaogang; Lee, Sang Bok; Hu, Liangbing] Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA.
[Xu, Kang] US Army Res Lab, Electrochem Branch, Power & Energy Div, Sensor & Electron Devices Directorate, Adelphi, MD 20783 USA.
RP Lee, SB (reprint author), Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA.
EM slee@umd.edu; binghu@umd.edu
RI Han, Xiaogang/D-6430-2015; Lee, Sang Bok/B-4421-2009; Hu,
Liangbing/N-6660-2013
OI Han, Xiaogang/0000-0002-4785-6506;
FU Nanostructures for Electrical Energy Storage (NEES), an Energy Frontier
Research Centre (EFRC) - U.S. Department of Energy, Office of Science,
Office of Basic Energy Sciences [DESC0001160]
FX This work was supported as part of the Nanostructures for Electrical
Energy Storage (NEES), an Energy Frontier Research Centre (EFRC) funded
by the U.S. Department of Energy, Office of Science, Office of Basic
Energy Sciences under Award Number DESC0001160. We also acknowledge the
Maryland NanoCenter and its NispLab for use of SEM and TEM.
NR 24
TC 3
Z9 3
U1 6
U2 81
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1388-0764
EI 1572-896X
J9 J NANOPART RES
JI J. Nanopart. Res.
PD NOV
PY 2014
VL 16
IS 11
AR 2745
DI 10.1007/s11051-014-2745-z
PG 8
WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials
Science, Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA AX1GX
UT WOS:000346696900070
ER
PT J
AU Legree, PJ
Psotka, J
Robbins, J
Roberts, RD
Putka, DJ
Mullins, HM
AF Legree, Peter J.
Psotka, Joseph
Robbins, Jordan
Roberts, Richard D.
Putka, Dan J.
Mullins, Heather M.
TI Profile Similarity Metrics as an Alternate Framework to Score
Rating-Based Tests: MSCEIT Reanalyses
SO INTELLIGENCE
LA English
DT Article
DE Profile Similarity Metrics; Emotional Intelligence; MSCEIT; Situational
Judgment; Consensus Based Assessment
ID SITUATIONAL JUDGMENT TESTS; EMOTIONAL INTELLIGENCE; TACIT KNOWLEDGE;
SATISFACTION; PERFORMANCE; COMMITMENT; MODELS
AB Profile similarity metrics provide an ideal framework to score rating-based judgment tests. These tests are distinct in asking subjects to rate the relative adequacy of multiple responses for each question. Respondent scores should be based on how well an individual's rating profile matches the answer key. However, respondents whose "rating-elevation" (tendency to give systematically low or high ratings) or "rating-scatter" (tendency to use more or less of the available scale) differs from the elevation and scatter of the scoring key can be given inappropriately low scores by distance-based algorithms. This can occur despite very high response accuracy with respect to the goal of correctly rating the relative adequacy of the response options for each question, "rating shape." Using this framework, reanalyses of MSCEIT data showed that after correcting scores for elevation and scatter effects, the MSCEIT is best described by a single factor that is highly g-loaded, (r = .79), not multiple factors with low g-loadings as hypothesized by its measurement model. These results demonstrate the importance of using profile similarity metrics (i.e., shape, elevation, and scatter) to evaluate the construct-related validity for rating-based judgment tests. Published by Elsevier Inc.
C1 [Legree, Peter J.; Psotka, Joseph; Robbins, Jordan; Mullins, Heather M.] US Army Res Inst Behav & Social Sci, Ft Belvoir, VA 22026 USA.
[Roberts, Richard D.] Profess Examinat Serv, New York, NY USA.
[Putka, Dan J.] Human Resources Res Org, Alexandria, VA USA.
RP Legree, PJ (reprint author), US Army Res Inst Behav & Social Sci, 6000 6th St Bldg 1464 Mail Stop 5610, Ft Belvoir, VA 22026 USA.
EM Peter.J.Legree.Civ@Mail.Mil
NR 27
TC 7
Z9 7
U1 2
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0160-2896
EI 1873-7935
J9 INTELLIGENCE
JI Intelligence
PD NOV-DEC
PY 2014
VL 47
BP 159
EP 174
DI 10.1016/j.intell.2014.09.005
PG 16
WC Psychology, Multidisciplinary
SC Psychology
GA AU9YR
UT WOS:000345948400018
ER
PT J
AU Grumstrup, EM
Gabriel, MM
Pinion, CW
Parker, JK
Cahoon, JF
Papanikolas, JM
AF Grumstrup, Erik M.
Gabriel, Michelle M.
Pinion, Christopher W.
Parker, James K.
Cahoon, James F.
Papanikolas, John M.
TI Reversible Strain-Induced Electron-Hole Recombination in Silicon
Nanowires Observed with Femtosecond Pump-Probe Microscopy
SO NANO LETTERS
LA English
DT Article
DE Ultrafast imaging; strained nanomaterials; spectroscopy
ID ULTRAFAST CARRIER DYNAMICS; BENT ZNO MICROWIRES; SURFACE RECOMBINATION;
CHARGE SEPARATION; MODULATION; SCATTERING; EMISSION; LIFETIME
AB Strain-induced changes to the electronic structure of nanoscale materials provide a promising avenue for expanding the optoelectronic functionality of semiconductor nanostructures in device applications. Here we use pump-probe microscopy with femtosecond temporal resolution and submicron spatial resolution to characterize charge-carrier recombination and transport dynamics in silicon nanowires (NWs) locally strained by bending deformation. The electron-hole recombination rate increases with strain for values above a threshold of similar to 1% and, in highly strained (similar to 5%) regions of the NW, increases 6-fold. The changes in recombination rate are independent of NW diameter and reversible upon reduction of the applied strain, indicating the effect originates from alterations to the NW bulk electronic structure rather than introduction of defects. The results highlight the strong relationship between strain, electronic structure, and charge-carrier dynamics in low-dimensional semiconductor systems, and we anticipate the results will assist the development of strain-enabled optoelectronic devices with indirect-bandgap materials such as silicon.
C1 [Grumstrup, Erik M.; Gabriel, Michelle M.; Pinion, Christopher W.; Cahoon, James F.; Papanikolas, John M.] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA.
[Grumstrup, Erik M.; Parker, James K.] US Army Res Off, Div Chem Sci, Res Triangle Pk, NC 27709 USA.
RP Grumstrup, EM (reprint author), Montana State Univ, Dept Chem & Biochem, Bozeman, MT 59717 USA.
EM erik.grumstrup@montana.edu; jfcahoon@unc.edu; john_papanikolas@unc.edu
FU National Science Foundation [CHE-1213379, DMR-1308695]; National
Research Council - Army Research Office
FX This project was supported by the National Science Foundation under
grant numbers CHE-1213379 (E.M.G., M.M.G, and J.M.P) and DMR-1308695
(C.W.P. and J.F.C.). E.M.G. was supported by a National Research Council
postdoctoral fellowship funded by the Army Research Office.
NR 31
TC 8
Z9 8
U1 4
U2 38
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1530-6984
EI 1530-6992
J9 NANO LETT
JI Nano Lett.
PD NOV
PY 2014
VL 14
IS 11
BP 6287
EP 6292
DI 10.1021/nl5026166
PG 6
WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied;
Physics, Condensed Matter
SC Chemistry; Science & Technology - Other Topics; Materials Science;
Physics
GA AU6PE
UT WOS:000345723800041
PM 25259929
ER
PT J
AU Wang, H
Wang, XM
Xia, FN
Wang, LH
Jiang, H
Xia, QF
Chin, ML
Dubey, M
Han, SJ
AF Wang, Han
Wang, Xiaomu
Xia, Fengnian
Wang, Luhao
Jiang, Hao
Xia, Qiangfei
Chin, Matthew L.
Dubey, Madan
Han, Shu-jen
TI Black Phosphorus Radio-Frequency Transistors
SO NANO LETTERS
LA English
DT Article
DE Black phosphorus; phosphorene; radio frequency; transistor; 2D
materials; graphene
ID THIN-FILM TRANSISTORS; FIELD-EFFECT TRANSISTORS; GRAPHENE TRANSISTORS;
GIGAHERTZ FREQUENCIES; ELECTRONICS; FT
AB Few-layer and thin film forms of layered black phosphorus (BP) have recently emerged as a promising material for applications in high performance nanoelectronics and infrared optoelectronics. Layered BP thin films offer a moderate bandgap of around 0.3 eV and high carrier mobility, which lead to transistors with decent onoff ratios and high on-state current densities. Here, we demonstrate the gigahertz frequency operation of BP field-effect transistors for the first time. The BP transistors demonstrated here show respectable current saturation with an onoff ratio that exceeds 2 x 10(3). We achieved a current density in excess of 270 mA/mm and DC transconductance above 180 mS/mm for hole conduction. Using standard high frequency characterization techniques, we measured a short-circuit current-gain cutoff frequency f(T) of 12 GHz and a maximum oscillation frequency f(max) of 20 GHz in 300 nm channel length devices. BP devices may offer advantages over graphene transistors for high frequency electronics in terms of voltage and power gain due to the good current saturation properties arising from their finite bandgap, thus can be considered as a promising candidate for the future high performance thin film electronics technology for operation in the multi-GHz frequency range and beyond.
C1 [Wang, Han; Wang, Luhao] Univ So Calif, Ming Hsieh Dept Elect Engn, Los Angeles, CA 90089 USA.
[Wang, Xiaomu; Xia, Fengnian] Yale Univ, Dept Elect Engn, New Haven, CT 06511 USA.
[Jiang, Hao; Xia, Qiangfei] Univ Massachusetts, Dept Elect & Comp Engn, Amherst, MA 01003 USA.
[Chin, Matthew L.; Dubey, Madan] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20723 USA.
[Han, Shu-jen] IBM TJ Watson Res Ctr, Yorktown Hts, NY 10598 USA.
RP Wang, H (reprint author), Univ So Calif, Ming Hsieh Dept Elect Engn, Los Angeles, CA 90089 USA.
EM han.wang.4@usc.edu; fengnian.xia@yale.edu
RI Xia, Fengnian/O-2637-2015; Wang, Xiaomu/Q-8638-2016
OI Xia, Fengnian/0000-0001-5176-368X;
FU Army Research Laboratory (ARL); Office of Naval Research (ONR); US Air
Force Office of Scientific Research (AFOSR) through a MURI grant
FX We thank T.-P. Ma at Yale University for the stimulating discussions on
the transistor performance. We thank M. Dresselhaus at MIT for the
valuable discussions on BP properties. We would like to thank Y. Jia at
Yale University for assistance in the measurement of the infrared
extinction spectra of BP flakes. We acknowledge W. Haensch and S. Guha
at IBM for their support of this work. H.W. acknowledges support from
the Army Research Laboratory (ARL). F.X. acknowledges support from the
Office of Naval Research (ONR). H.J. and Q.X. are partially supported by
the US Air Force Office of Scientific Research (AFOSR) through a MURI
grant.
NR 42
TC 98
Z9 98
U1 13
U2 176
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1530-6984
EI 1530-6992
J9 NANO LETT
JI Nano Lett.
PD NOV
PY 2014
VL 14
IS 11
BP 6424
EP 6429
DI 10.1021/nl5029717
PG 6
WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied;
Physics, Condensed Matter
SC Chemistry; Science & Technology - Other Topics; Materials Science;
Physics
GA AU6PE
UT WOS:000345723800062
PM 25347787
ER
PT J
AU Quinn, MCL
Taylor, ODS
AF Quinn, Meghan C. L.
Taylor, Oliver-Denzil S.
TI Hazard Topography: Visual Approach for Identifying Critical Failure
Combinations for Infrastructure
SO NATURAL HAZARDS REVIEW
LA English
DT Article
DE Natural disasters; Slope stability; Finite element method; Public safety
ID EARTH DAMS
AB Infrastructure catastrophes, such as the levee failure during Hurricane Katrina and the Fukashima nuclear disaster, are often triggered by a critical combination of events. Typically, engineers evaluate the risk of failure of infrastructure for a single probabilistic combination of events. This paper focuses on a visual multihazard evaluation method to evaluate infrastructure stability and critical hazard combinations. To present this method, the authors considered the multihazard stability of a flood control earth embankment, evaluated by calculating a factor of safety (FS). Multihazard topography promotes the comparison of design/repair options with stability and two other variables that affect stability. This evaluation tool will assist engineers, owners, and regulatory agencies in the best design or best mitigation evaluation process (for both cost and hazard reduction). (C) 2014 American Society of Civil Engineers.
C1 [Quinn, Meghan C. L.] US Army Corps Engn, Concord, MA 01742 USA.
[Taylor, Oliver-Denzil S.] US Army Engn Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA.
RP Quinn, MCL (reprint author), US Army Corps Engn, Concord, MA 01742 USA.
EM meghan.c.quinn@usace.army.mil; oliver.d.taylor@usace.army.mil
FU Geotechnical and Structures Laboratory, Engineer Research and
Development Center
FX Research funding and permission to publish was granted by Director,
Geotechnical and Structures Laboratory, Engineer Research and
Development Center, and the report is approved for public release;
distribution is unlimited.
NR 22
TC 2
Z9 2
U1 4
U2 16
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 1527-6988
EI 1527-6996
J9 NAT HAZARDS REV
JI Nat. Hazards Rev.
PD NOV
PY 2014
VL 15
IS 4
AR 04014012
DI 10.1061/(ASCE)NH.1527-6996.0000131
PG 13
WC Engineering, Civil; Environmental Studies; Geosciences,
Multidisciplinary; Meteorology & Atmospheric Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Geology; Meteorology &
Atmospheric Sciences; Water Resources
GA AU6XH
UT WOS:000345744200005
ER
PT J
AU Warren, TK
Trefry, JC
Marko, ST
Chance, TB
Wells, JB
Pratt, WD
Johnson, JC
Mucker, EM
Norris, SL
Chappell, M
Dye, JM
Honko, AN
AF Warren, Travis K.
Trefry, John C.
Marko, Shannon T.
Chance, Taylor B.
Wells, Jay B.
Pratt, William D.
Johnson, Joshua C.
Mucker, Eric M.
Norris, Sarah L.
Chappell, Mark
Dye, John M.
Honko, Anna N.
TI Euthanasia Assessment in Ebola Virus Infected Nonhuman Primates
SO VIRUSES-BASEL
LA English
DT Article
DE filovirus; nonhuman primate; viral hemorrhagic fever; euthanasia;
clinical pathology; Ebola virus
ID POSTEXPOSURE PROTECTION; HEMORRHAGIC-FEVER; RHESUS-MONKEYS; DISEASE;
CHALLENGE
AB Multiple products are being developed for use against filoviral infections. Efficacy for these products will likely be demonstrated in nonhuman primate models of filoviral disease to satisfy licensure requirements under the Animal Rule, or to supplement human data. Typically, the endpoint for efficacy assessment will be survival following challenge; however, there exists no standardized approach for assessing the health or euthanasia criteria for filovirus-exposed nonhuman primates. Consideration of objective criteria is important to (a) ensure test subjects are euthanized without unnecessary distress; (b) enhance the likelihood that animals exhibiting mild or moderate signs of disease are not prematurely euthanized; (c) minimize the occurrence of spontaneous deaths and loss of end-stage samples; (d) enhance the reproducibility of experiments between different researchers; and (e) provide a defensible rationale for euthanasia decisions that withstands regulatory scrutiny. Historic records were compiled for 58 surviving and non-surviving monkeys exposed to Ebola virus at the US Army Medical Research Institute of Infectious Diseases. Clinical pathology parameters were statistically analyzed and those exhibiting predicative value for survival are reported. These findings may be useful for standardization of objective euthanasia assessments in rhesus monkeys exposed to Ebola virus and may serve as a useful approach for other standardization efforts.
C1 [Warren, Travis K.; Trefry, John C.; Marko, Shannon T.; Chance, Taylor B.; Wells, Jay B.; Pratt, William D.; Johnson, Joshua C.; Mucker, Eric M.; Norris, Sarah L.; Chappell, Mark; Dye, John M.; Honko, Anna N.] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
[Marko, Shannon T.] Madigan Army Med Ctr, Tacoma, WA 98431 USA.
[Johnson, Joshua C.; Honko, Anna N.] NIAID, Integrated Res Facil, Ft Detrick, MD 21702 USA.
[Chappell, Mark] Armed Forces Radiobiol Res Inst, Bethesda, MD 20889 USA.
RP Warren, TK (reprint author), US Army, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA.
EM travis.k.warren.ctr@mail.mil; john.c.trefry.ctr@mail.mil;
shannon.t.marko.mil@mail.mil; taylor.b.chance.mil@mail.mil;
jay.b.wells.ctr@mail.mil; william.d.pratt4.civ@mail.mil;
joshua.johnson@nih.gov; eric.m.mucker.ctr@mail.mil;
sarah.l.norris2.civ@mail.mil; mark.chappell@usuhs.edu;
john.m.dye1.civ@mail.mil; anna.honko@nih.gov
OI Johnson, Joshua/0000-0002-5677-3841; Honko, Anna/0000-0001-9165-148X
FU Defense Threat Reduction Agency
FX Financial contributions for this work were provided in part by the
Defense Threat Reduction Agency. The authors acknowledge the
contributions of the numerous individuals who participated in the
historic nonhuman primate evaluations described in this report.
Opinions, interpretations, conclusions, and recommendations are those of
the authors and are not necessarily endorsed by the U.S. Army. Research
was conducted under an IACUC approved protocol in compliance with the
Animal Welfare Act, PHS Policy, and other Federal statutes and
regulations relating to animals and experiments involving animals. The
facility where this research was conducted is accredited by the
Association for Assessment and Accreditation of Laboratory Animal Care,
International and adheres to principles stated in the Guide for the Care
and Use of Laboratory Animals, National Research Council, 2011.
NR 22
TC 6
Z9 6
U1 0
U2 11
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 1999-4915
J9 VIRUSES-BASEL
JI Viruses-Basel
PD NOV
PY 2014
VL 6
IS 11
BP 4666
EP 4682
DI 10.3390/v6114666
PG 17
WC Virology
SC Virology
GA AU4FL
UT WOS:000345565200031
PM 25421892
ER
PT J
AU Kuhn, JH
Andersen, KG
Baize, S
Bao, YM
Bavari, S
Berthet, N
Blinkova, O
Brister, JR
Clawson, AN
Fair, J
Gabriel, M
Garry, RF
Gire, SK
Goba, A
Gonzalez, JP
Gunther, S
Happi, CT
Jahrling, PB
Kapetshi, J
Kobinger, G
Kugelman, JR
Leroy, EM
Maganga, GD
Mbala, PK
Moses, LM
Muyembe-Tamfum, JJ
N'Faly, M
Nichol, ST
Omilabu, SA
Palacios, G
Park, DJ
Paweska, JT
Radoshitzky, SR
Rossi, CA
Sabeti, PC
Schieffelin, JS
Schoepp, RJ
Sealfon, R
Swanepoel, R
Towner, JS
Wada, J
Wauquier, N
Yozwiak, NL
Formenty, P
AF Kuhn, Jens H.
Andersen, Kristian G.
Baize, Sylvain
Bao, Yiming
Bavari, Sina
Berthet, Nicolas
Blinkova, Olga
Brister, J. Rodney
Clawson, Anna N.
Fair, Joseph
Gabriel, Martin
Garry, Robert F.
Gire, Stephen K.
Goba, Augustine
Gonzalez, Jean-Paul
Guenther, Stephan
Happi, Christian T.
Jahrling, Peter B.
Kapetshi, Jimmy
Kobinger, Gary
Kugelman, Jeffrey R.
Leroy, Eric M.
Maganga, Gael Darren
Mbala, Placide K.
Moses, Lina M.
Muyembe-Tamfum, Jean-Jacques
N'Faly, Magassouba
Nichol, Stuart T.
Omilabu, Sunday A.
Palacios, Gustavo
Park, Daniel J.
Paweska, Janusz T.
Radoshitzky, Sheli R.
Rossi, Cynthia A.
Sabeti, Pardis C.
Schieffelin, John S.
Schoepp, Randal J.
Sealfon, Rachel
Swanepoel, Robert
Towner, Jonathan S.
Wada, Jiro
Wauquier, Nadia
Yozwiak, Nathan L.
Formenty, Pierre
TI Nomenclature- and Database-Compatible Names for the Two Ebola Virus
Variants that Emerged in Guinea and the Democratic Republic of the Congo
in 2014
SO VIRUSES-BASEL
LA English
DT Article
DE Ebola; Ebola virus; ebolavirus; filovirid; Filoviridae; filovirus;
genome annotation; Lomela; Lokolia; Makona; mononegavirad;
Mononegavirales; mononegavirus; virus classification; virus isolate;
virus nomenclature; virus strain; virus taxonomy; virus variant
ID INTERNATIONAL COMMITTEE; TAXONOMIC PROPOSALS; FAMILY FILOVIRIDAE;
RATIFICATION VOTE
AB In 2014, Ebola virus (EBOV) was identified as the etiological agent of a large and still expanding outbreak of Ebola virus disease (EVD) in West Africa and a much more confined EVD outbreak in Middle Africa. Epidemiological and evolutionary analyses confirmed that all cases of both outbreaks are connected to a single introduction each of EBOV into human populations and that both outbreaks are not directly connected. Coding-complete genomic sequence analyses of isolates revealed that the two outbreaks were caused by two novel EBOV variants, and initial clinical observations suggest that neither of them should be considered strains. Here we present consensus decisions on naming for both variants (West Africa: "Makona", Middle Africa: "Lomela") and provide database-compatible full, shortened, and abbreviated names that are in line with recently established filovirus sub-species nomenclatures.
C1 [Kuhn, Jens H.; Clawson, Anna N.; Jahrling, Peter B.; Wada, Jiro] NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD 21702 USA.
[Andersen, Kristian G.; Gire, Stephen K.; Sabeti, Pardis C.; Yozwiak, Nathan L.] Harvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USA.
[Baize, Sylvain] Inst Pasteur, Unite Biol Infect Virales Emergentes, Lyon, France.
[Baize, Sylvain] Univ Lyon 1, CNRS, Ecole Normale Super Lyon, CIRI,INSERM,U1111,UMR5308, F-69365 Lyon, France.
[Bao, Yiming; Blinkova, Olga; Brister, J. Rodney] NIH, Informat Engn Branch, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20894 USA.
[Bavari, Sina; Kugelman, Jeffrey R.; Palacios, Gustavo; Radoshitzky, Sheli R.; Rossi, Cynthia A.; Schoepp, Randal J.] US Army, Med Res Inst Infect Dis, Frederick, MD 21702 USA.
[Berthet, Nicolas; Leroy, Eric M.; Maganga, Gael Darren] Ctr Int Rech Med Franceville, Franceville, Gabon.
[Fair, Joseph] Fdn Merieux, Washington, DC 20036 USA.
[Gabriel, Martin; Guenther, Stephan] WHO, Bernhard Nocht Inst Trop Med, Collaborating Ctr Arbovirus & Hemorrhag Fever Ref, D-20259 Hamburg, Germany.
[Gabriel, Martin; Guenther, Stephan] German Ctr Infect Res DZIF, D-20259 Hamburg, Germany.
[Garry, Robert F.; Moses, Lina M.; Schieffelin, John S.] Tulane Univ, Sch Med, New Orleans, LA 70112 USA.
[Goba, Augustine] Kenema Govt Hosp, Kenema, Sierra Leone.
[Gonzalez, Jean-Paul; Wauquier, Nadia] Metabiota Inc, San Francisco, CA 94104 USA.
[Happi, Christian T.] Redeemers Univ, Coll Nat Sci, Dept Biol Sci, Mowe, Ogun State, Nigeria.
[Happi, Christian T.] Redeemers Univ, African Ctr Excellence Genom Infect Dis, Mowe, Ogun State, Nigeria.
[Kobinger, Gary] Publ Hlth Agcy Canada, Natl Microbiol Lab, Special Pathogens Program, Winnipeg, MB R3E 3R2, Canada.
[N'Faly, Magassouba] Univ Gamal Abdel Nasser de Conakry, Lab Fievres Hemorrag Guinee, Hop Natl Donka, Serv Malad Infect & Trop, Conakry, Guinea.
[Nichol, Stuart T.; Towner, Jonathan S.] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Div High Consequence Pathogens & Pathol, Viral Special Pathogens Branch, Atlanta, GA 30333 USA.
[Omilabu, Sunday A.] Univ Lagos, Coll Med, Dept Med Microbiol & Parasitol, Lagos, Nigeria.
[Park, Daniel J.] Broad Inst, Cambridge, MA 02142 USA.
[Paweska, Janusz T.] Natl Hlth Lab Serv, Natl Inst Communicable Dis, Ctr Emerging & Zoonot Dis, ZA-2192 Sandringham Johannesburg, Gauteng, South Africa.
[Sealfon, Rachel] MIT, Comp Sci & Artificial Intelligence Lab, Cambridge, MA 02139 USA.
[Swanepoel, Robert] Univ Pretoria, Zoonoses Res Unit, ZA-0028 Pretoria, South Africa.
[Formenty, Pierre] WHO, CH-1211 Geneva, Switzerland.
RP Kuhn, JH (reprint author), NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD 21702 USA.
EM kuhnjens@mail.nih.gov; kandersen@oeb.harvard.edu;
sylvain.baize@inserm.fr; bao@ncbi.nlm.nih.gov; sina.bavari.civ@mail.mil;
nicolas.berthet@pasteur.fr; olga.blinkova@nih.gov;
jamesbr@ncbi.nlm.nih.gov; anna@logosconsulting.us;
joseph.fair@fondation-merieux.org; gabriel@bni-hamburg.de;
rfgarry@tulane.edu; sgire@oeb.harvard.edu; augstgoba@yahoo.com;
jpgonzalez@metabiota.com; guenther@bni.uni-hamburg.de;
happic@run.edu.ng; jahrlingp@niaid.nih.gov; jimmy_kap@hotmail.com;
gary.kobinger@phac-aspc.gc.ca; jeffrey.r.kugelman.mil@mail.mil;
eric.leroy@ird.fr; gael_maganga@yahoo.fr; mbalaplacide@gmail.com;
lmoses2@tulane.edu; muyembejj@gmail.com; cmagassouba01@gmail.com;
stn1@cdc.gov; omilabusa@yahoo.com; gustavo.f.palacios.ctr@us.army.mil;
dpark@broadinstitute.org; januszp@nicd.ac.za;
sheli.r.radoshitzky.ctr@mail.mil; cynthia.a.rossi.civ@mail.mil;
pardis@broadinstitute.org; jschieff@tulane.edu;
randal.j.schoepp.civ@mail.mil; sealfon@gmail.com;
bobswanepoel@gmail.com; jit8@cdc.gov; wadaj@niaid.nih.gov;
nadia.wauquier@gmail.com; nyozwiak@broadinstitute.org; formentyp@who.int
RI Berthet, Nicolas/J-9373-2012; Kuhn, Jens H./B-7615-2011; Palacios,
Gustavo/I-7773-2015; LEROY, Eric/I-4347-2016
OI Kuhn, Jens H./0000-0002-7800-6045; Palacios,
Gustavo/0000-0001-5062-1938; LEROY, Eric/0000-0003-0022-0890
FU Battelle Memorial Institute; US National Institute of Allergy and
Infectious Diseases (NIAID) [HHSN272200700016I]; Intramural Research
Program of the NIH, National Library of Medicine
FX We thank Laura Bollinger (IRF-Frederick) for carefully editing the
manuscript. The content of this publication does not necessarily reflect
the views or policies of the US Department of Health and Human Services
(DHHS) or of the institutions and companies affiliated with the authors.
This work was funded in part through Battelle Memorial Institute's prime
contract with the US National Institute of Allergy and Infectious
Diseases (NIAID) under Contract No. HHSN272200700016I. J.W. performed
this work as an employee of Battelle Memorial Institute. Subcontractors
to Battelle Memorial Institute who performed this work are: J.H.K., an
employee of Tunnell Government Services, Inc. This research was further
supported in part by the Intramural Research Program of the NIH,
National Library of Medicine (Y.B., O.B., and J.R.B.).
NR 22
TC 39
Z9 41
U1 3
U2 29
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 1999-4915
J9 VIRUSES-BASEL
JI Viruses-Basel
PD NOV
PY 2014
VL 6
IS 11
BP 4760
EP 4799
DI 10.3390/v6114760
PG 40
WC Virology
SC Virology
GA AU4FL
UT WOS:000345565200035
PM 25421896
ER
PT J
AU Biddle, TD
AF Biddle, Tami Davis
TI The Bombing War: Europe, 1939-1945
SO WAR IN HISTORY
LA English
DT Book Review
C1 [Biddle, Tami Davis] US Army War Coll, Carlisle, PA USA.
RP Biddle, TD (reprint author), US Army War Coll, Carlisle, PA USA.
NR 1
TC 0
Z9 0
U1 0
U2 1
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0968-3445
EI 1477-0385
J9 WAR HIST
JI War Hist.
PD NOV
PY 2014
VL 21
IS 4
BP 553
EP 555
PG 3
WC History; International Relations
SC History; International Relations
GA AU6RX
UT WOS:000345730600024
ER
PT J
AU Richardson, L
Keefe, K
Huber, C
Racevskis, L
Reynolds, G
Thourot, S
Miller, I
AF Richardson, Leslie
Keefe, Kelly
Huber, Christopher
Racevskis, Laila
Reynolds, Gregg
Thourot, Scott
Miller, Ian
TI Assessing the value of the Central Everglades Planning Project (CEPP) in
Everglades restoration: An ecosystem service approach
SO ECOLOGICAL ECONOMICS
LA English
DT Article
DE Ecosystem services; Nonmarket valuation; Peat accretion; Carbon
sequestration; Comprehensive Everglades Restoration Plan (CERP); Central
Everglades Planning Project (CEPP); Benefit transfer
ID CONCEPTUAL ECOLOGICAL MODEL; CALOOSAHATCHEE-ESTUARY; AGRICULTURAL AREA;
SOUTH FLORIDA; ORGANIC SOILS; WATER-QUALITY; NATIONAL-PARK; FIRE
REGIMES; PINK SHRIMP; SUBSIDENCE
AB This study identifies a full range of ecosystem services that could be affected by a restoration project in the central Everglades and monetizes the economic value of a subset of these services using existing data. Findings suggest that the project will potentially increase many ecosystem services that have considerable economic value to society. The ecosystem services monetized within the scope of this study are a subset of the difference between the future-with the Central Everglades Planning Project (CEPP) and the future-without CEPP, and they totaled similar to $1.8 billion USD at a 2.5% discount rate. Findings suggest that the use of ecosystem services in project planning and communications may require acknowledgment of the difficulty of monetizing important services and the limitations associated with using only existing data and models. Results of this study highlight the need for additional valuation efforts in this region, focused on those services that are likely to be impacted by restoration activities but were notably challenging to value in this assessment due to shortages of data. Published by Elsevier B.V.
C1 [Richardson, Leslie; Huber, Christopher] US Geol Survey, Ft Collins Sci Ctr, Ft Collins, CO 80526 USA.
[Keefe, Kelly] US Army Corps Engineers, Cent Everglades Branch, Jacksonville, FL 32217 USA.
[Racevskis, Laila] Univ Florida, Food & Resource Econ Dept, Gainesville, FL 32611 USA.
[Reynolds, Gregg] South Florida Ecosyst Off, Everglades Natl Pk, Natl Pk Serv, Homestead, FL 33030 USA.
[Thourot, Scott; Miller, Ian] South Florida Water Management Dist, W Palm Beach, FL 33406 USA.
RP Richardson, L (reprint author), US Geol Survey, Ft Collins Sci Ctr, 2150 Ctr Ave,Bldg C, Ft Collins, CO 80526 USA.
EM lrichardson@usgs.gov; KellyJ.Keefe@usace.army.mil; chuber@usgs.gov;
gregg_reynolds@nps.gov; sthourot@sfwmd.gov; imiller@sfwmd.gov
FU U.S. Army Corps of Engineers; South Florida Water Management District
FX This work was funded by cost sharing between the U.S. Army Corps of
Engineers and the South Florida Water Management District within the
Comprehensive Everglades Restoration Plan. In addition to the two
anonymous peer reviewers who provided very insightful comments, this
work benefitted tremendously from the following contributors and
reviewers: Rick Anderson, Joan Browder, Eric Bush, David Crane, Janet
Cushing, Vic Engel, Jason Godin, Patti Gorman, Chris Kelble, Jerry
Krenz, Agnes McLean, Christopher McVoy, Max Millstein, Barron Moody,
Matt Morrison, Elizabeth Murray, Sashi Nair, Melissa Nasuti, Todd
Osborne, Leonard Pearlstine, Marshall Plumley, K. Ramesh Reddy, Jed
Redwine, Stephanie Romanach, Paul Scodari, Liberta Scotto, Tom Teets,
Kim Taplin, Steve Traxler, Lisa Wainger, Harden Waddle, Walter Wilcox,
and Kevin Wittmann. Any errors or omissions are those of the authors
alone.
NR 94
TC 1
Z9 1
U1 5
U2 40
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0921-8009
EI 1873-6106
J9 ECOL ECON
JI Ecol. Econ.
PD NOV
PY 2014
VL 107
BP 366
EP 377
DI 10.1016/j.ecolecon.2014.09.011
PG 12
WC Ecology; Economics; Environmental Sciences; Environmental Studies
SC Environmental Sciences & Ecology; Business & Economics
GA AU2WG
UT WOS:000345474800035
ER
PT J
AU Zhao, Y
Strope, PK
Kozmin, SG
McCusker, JH
Dietrich, FS
Kokoska, RJ
Petes, TD
AF Zhao, Ying
Strope, Pooja K.
Kozmin, Stanislav G.
McCusker, John H.
Dietrich, Fred S.
Kokoska, Robert J.
Petes, Thomas D.
TI Structures of Naturally Evolved CUP1 Tandem Arrays in Yeast Indicate
That These Arrays Are Generated by Unequal Nonhomologous Recombination
SO G3-GENES GENOMES GENETICS
LA English
DT Article
DE copper resistance; tandemly repeated genes; recombination; Saccharomyces
cerevisiae
ID COPY-NUMBER VARIATION; SACCHAROMYCES-CEREVISIAE; GENE AMPLIFICATION;
DNA-REPLICATION; COPPER RESISTANCE; RIBOSOMAL DNA; REARRANGEMENTS;
TRANSCRIPTION; EVOLUTION; SEQUENCE
AB An important issue in genome evolution is the mechanism by which tandem duplications are generated from single-copy genes. In the yeast Saccharomyces cerevisiae, most strains contain tandemly duplicated copies of CUP1, a gene that encodes a copper-binding metallothionein. By screening 101 natural isolates of S. cerevisiae, we identified five different types of CUP1-containing repeats, as well as strains that only had one copy of CUP1. A comparison of the DNA sequences of these strains indicates that the CUP1 tandem arrays were generated by unequal nonhomologous recombination events from strains that had one CUP1 gene.
C1 [Zhao, Ying; Strope, Pooja K.; Kozmin, Stanislav G.; McCusker, John H.; Dietrich, Fred S.; Petes, Thomas D.] Duke Univ, Dept Mol Genet & Microbiol, Med Ctr, Durham, NC 27710 USA.
[Zhao, Ying; Strope, Pooja K.; Kozmin, Stanislav G.; McCusker, John H.; Dietrich, Fred S.; Petes, Thomas D.] Duke Univ, Univ Program Genet & Genom, Med Ctr, Durham, NC 27710 USA.
[Kokoska, Robert J.] US Army Res Off, Phys Sci Directorate, Res Triangle Pk, NC 27709 USA.
RP Petes, TD (reprint author), Duke Univ, Dept Mol Genet & Microbiol, Med Ctr, 213 Res Dr, Durham, NC 27710 USA.
EM tom.petes@duke.edu
FU National Institutes of Health [GM24110, GM52319, GM098287, T32
AI052080]; Army Research Office (SPS) [200531]
FX We thank D. Thiel for the yeast strain DTY3, and Y. Yin, S. Andersen,
and S. Jinks-Robertson for comments on the manuscript. The research was
supported by National Institutes of Health grants GM24110 and GM52319 to
T. P. and GM098287 to J.H.M. Y.Z. and P. K. S. were supported by grants
from the Army Research Office (SPS #200531), and the National Institutes
of Health (T32 AI052080), respectively.
NR 39
TC 8
Z9 8
U1 1
U2 3
PU GENETICS SOCIETY AMERICA
PI BETHESDA
PA 9650 ROCKVILLE AVE, BETHESDA, MD 20814 USA
SN 2160-1836
J9 G3-GENES GENOM GENET
JI G3-Genes Genomes Genet.
PD NOV 1
PY 2014
VL 4
IS 11
BP 2259
EP 2269
DI 10.1534/g3.114.012922
PG 11
WC Genetics & Heredity
SC Genetics & Heredity
GA AU0BR
UT WOS:000345288700021
PM 25236733
ER
PT J
AU Kim, Y
Mohan, S
Siegel, JB
Stefanopoulou, AG
Ding, Y
AF Kim, Youngki
Mohan, Shankar
Siegel, Jason B.
Stefanopoulou, Anna G.
Ding, Yi
TI The Estimation of Temperature Distribution in Cylindrical Battery Cells
Under Unknown Cooling Conditions
SO IEEE TRANSACTIONS ON CONTROL SYSTEMS TECHNOLOGY
LA English
DT Article
DE Dual Kalman filter (DKF); lithium ion (Li-ion) batteries; reduced-order
model; state and parameter estimation; thermal modeling
ID LITHIUM-ION BATTERY; THERMAL-ANALYSIS; PERFORMANCE; MODEL; ELECTRODE;
BEHAVIOR; CYCLE
AB The estimation of temperature inside a battery cell requires accurate information about the cooling conditions even when the battery surface temperature is measured. This paper presents a model-based approach for estimating temperature distribution inside a cylindrical battery under unknown convective cooling conditions. A reduced-order thermal model using a polynomial approximation of the temperature profile inside the battery is used. A dual Kalman filter (DKF), a combination of a Kalman filter and an extended Kalman filter, is then applied for the identification of the convection coefficient and the estimation of the battery core temperature. The thermal properties are modeled by volume averaged lumped-values under the assumption of a homogeneous and isotropic volume. The model is parameterized and validated using experimental data from a 2.3 Ah 26 650 lithium-iron-phosphate battery cell with a forced-air convective cooling during hybrid electric vehicle drive cycles. Experimental results show that the proposed DKF-based estimation method can provide an accurate prediction of the core temperature under unknown cooling conditions by measuring battery current and voltage along with surface and ambient temperatures.
C1 [Kim, Youngki; Siegel, Jason B.; Stefanopoulou, Anna G.] Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA.
[Mohan, Shankar] Univ Michigan, Dept Elect Engn, Ann Arbor, MI 48109 USA.
[Ding, Yi] US Army Tank Automot Res Dev & Engn Ctr, Warren, MI 48397 USA.
RP Kim, Y (reprint author), Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA.
EM youngki@umich.edu; elemsn@umich.edu; siegeljb@umich.edu;
annastef@umich.edu; yi.ding8.civ@mail.mil
OI Mohan, Shankar/0000-0002-6107-7672
FU Automotive Research Center [W56HZV-04-2-0001]; U.S. Army Tank Automotive
Research, Development and Engineering Center, Warren, MI, USA
FX This work was supported in part by the Automotive Research Center
through the Cooperative Agreement under Grant W56HZV-04-2-0001 and in
part by the U.S. Army Tank Automotive Research, Development and
Engineering Center, Warren, MI, USA. Recommended by Associate Editor S.
Varigonda.
NR 31
TC 21
Z9 21
U1 2
U2 20
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1063-6536
EI 1558-0865
J9 IEEE T CONTR SYST T
JI IEEE Trans. Control Syst. Technol.
PD NOV
PY 2014
VL 22
IS 6
BP 2277
EP 2286
DI 10.1109/TCST.2014.2309492
PG 10
WC Automation & Control Systems; Engineering, Electrical & Electronic
SC Automation & Control Systems; Engineering
GA AU4JH
UT WOS:000345576300016
ER
PT J
AU Wildman, RA
Gazonas, GA
AF Wildman, Raymond A.
Gazonas, George A.
TI A finite difference-augmented peridynamics method for reducing wave
dispersion
SO INTERNATIONAL JOURNAL OF FRACTURE
LA English
DT Article
DE Finite difference; Peridynamics; Fracture; Wave propagation
ID TRANSIENT HEAT-CONDUCTION; LONG-RANGE FORCES; MAXWELLS EQUATIONS;
ADAPTIVE REFINEMENT; NUMERICAL-SOLUTION; ELASTIC-WAVES; PROPAGATION;
MEDIA; MECHANICS; SCHEME
AB A method is presented for the modeling of brittle elastic fracture which combines peridynamics and a finite difference method to mitigate the wave dispersion properties of peridynamics. Essentially, a finite difference method is used in the bulk for wave propagation modeling, while peridynamics is automatically inserted in high strain areas to model crack initiation and growth. The dispersion properties of finite difference methods and discretized peridynamics are reviewed and the interface reflection properties between the two regions are investigated. Results show that the augmented method can improve the modeling of wave propagation and boundary conditions. In addition, the numerical stress intensity factor computed at a crack tip shows reduced oscillations in the augmented method, likely due to the improved dispersion properties of the bulk. Dynamic fracture simulations show a difference in crack paths between the methods.
C1 [Wildman, Raymond A.; Gazonas, George A.] US Army Res Lab, Attn RDRL WMM B, Aberdeen, MD 21005 USA.
RP Wildman, RA (reprint author), US Army Res Lab, Attn RDRL WMM B, Aberdeen, MD 21005 USA.
EM raymond.a.wildman.civ@mail.mil
OI Gazonas, George/0000-0002-2715-016X
NR 32
TC 4
Z9 4
U1 2
U2 6
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0376-9429
EI 1573-2673
J9 INT J FRACTURE
JI Int. J. Fract.
PD NOV
PY 2014
VL 190
IS 1-2
BP 39
EP 52
DI 10.1007/s10704-014-9973-1
PG 14
WC Materials Science, Multidisciplinary; Mechanics
SC Materials Science; Mechanics
GA AU1WR
UT WOS:000345408700003
ER
PT J
AU Reiter, MJ
Schwope, RB
Kini, JA
York, GE
Theler, JM
AF Reiter, Michael J.
Schwope, Ryan B.
Kini, Jonathan A.
York, Gerald E.
Theler, Jared M.
TI Computed Tomography Imaging Manifestations of Commonly Used Materials in
Posttraumatic Craniofacial Repair
SO JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY
LA English
DT Review
DE bone graft; alloplast; craniofacial; trauma; CT
ID BONE-GRAFT MATERIALS; ORBITAL IMPLANTS; BIOMATERIALS; RECONSTRUCTION;
SUBSTITUTES
AB An expansive array of materials exists within the armamentarium of craniofacial surgeons. For patients undergoing repair of posttraumatic injuries, computed tomography is the imaging modality of choice in the postoperative setting. Therefore, radiologists will invariably encounter implants constructed with various materials, depending on the surgeon's preference. The appearance of these materials on computed tomography is broad, ranging from hyperdense to radiolucent. To avoid misdiagnosis, radiologists should be familiar with all of the materials currently in use.
C1 [Reiter, Michael J.; Schwope, Ryan B.; Kini, Jonathan A.; York, Gerald E.] Brooke Army Med Ctr, Dept Radiol, San Antonio, TX 78234 USA.
[Reiter, Michael J.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Theler, Jared M.] Brooke Army Med Ctr, Dept Otolaryngol, San Antonio, TX 78234 USA.
RP Reiter, MJ (reprint author), Brooke Army Med Ctr, Dept Radiol, 3551 Roger Brooke Dr, San Antonio, TX 78234 USA.
EM mikereiter13@yahoo.com
NR 20
TC 1
Z9 1
U1 1
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0363-8715
EI 1532-3145
J9 J COMPUT ASSIST TOMO
JI J. Comput. Assist. Tomogr.
PD NOV-DEC
PY 2014
VL 38
IS 6
BP 890
EP 897
PG 8
WC Radiology, Nuclear Medicine & Medical Imaging
SC Radiology, Nuclear Medicine & Medical Imaging
GA AU2EW
UT WOS:000345430200014
PM 25119065
ER
EF