FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Maust, MS Muramatsu, RS Egan, K Ahmed, I AF Maust, Michelle Samson Muramatsu, Russ S. Egan, Kathryn Ahmed, Iqbal TI Perphenazine-Associated Hyperosmolar Hyperglycemic State SO JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY LA English DT Letter ID ATYPICAL ANTIPSYCHOTICS; DIABETES-MELLITUS; COMA; RISK C1 [Maust, Michelle Samson; Muramatsu, Russ S.; Egan, Kathryn; Ahmed, Iqbal] Tripler Army Med Ctr, Dept Behav Hlth, Honolulu, HI 96859 USA. RP Maust, MS (reprint author), Tripler Army Med Ctr, Dept Behav Hlth, Honolulu, HI 96859 USA. EM michelle.s.maust.mil@mail.mil NR 20 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0271-0749 EI 1533-712X J9 J CLIN PSYCHOPHARM JI J. Clin. Psychopharmacol. PD AUG PY 2015 VL 35 IS 4 BP 485 EP 486 DI 10.1097/JCP.0000000000000359 PG 2 WC Pharmacology & Pharmacy; Psychiatry SC Pharmacology & Pharmacy; Psychiatry GA CM4QP UT WOS:000357670000033 PM 26120945 ER PT J AU Peatey, CL Chavchich, M Chen, NH Gresty, KJ Gray, KA Gatton, ML Waters, NC Cheng, Q AF Peatey, Christopher L. Chavchich, Marina Chen, Nanhua Gresty, Karryn J. Gray, Karen-Ann Gatton, Michelle L. Waters, Norman C. Cheng, Qin TI Mitochondrial Membrane Potential in a Small Subset of Artemisinin-Induced Dormant Plasmodium falciparum Parasites In Vitro SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE P. falciparum; artemisinin; dihydroartemisinin (DHA); dormancy; mitochondrial membrane potential ID ASEXUAL BLOOD STAGES; WESTERN CAMBODIA; ERYTHROCYTIC STAGES; TREATMENT FAILURE; RING STAGES; MALARIA; RHODAMINE-123; QUIESCENCE; MECHANISM AB Artemisinin-induced dormancy is a proposed mechanism for failures of monotherapy and is linked with artemisinin resistance in Plasmodium falciparum. The biological characterization and dynamics of dormant parasites are not well understood. Here we report that after dihydroartemisinin treatment in vitro, a small subset of morphologically dormant parasites was stained with rhodamine 123 (RH), a mitochondrial membrane potential marker, and persisted to recovery. RH-positive parasites sorted with fluorescence-activated cell sorting resumed growth at 10000/well whereas RH-negative parasites failed to recover at 5 million/well. Furthermore, transcriptional activity for mitochondrial enzymes was detected only in RH-positive dormant parasites. Importantly, after treatment of dormant parasites with different concentrations of atovaquone, a mitochondrial inhibitor, the recovery of dormant parasites was delayed or stopped. This demonstrates that mitochondrial activity is critical for survival and regrowth of dormant parasites and that RH staining provides a means of identifying these parasites. These findings provide novel paths for studying and eradicating this dormant stage. C1 [Peatey, Christopher L.; Chavchich, Marina; Chen, Nanhua; Gresty, Karryn J.; Gray, Karen-Ann; Cheng, Qin] Australian Army Malaria Inst, Drug Resistance & Diagnost, Brisbane, Qld, Australia. [Peatey, Christopher L.; Gresty, Karryn J.; Gray, Karen-Ann; Cheng, Qin] QIMR Berghofer Med Res Inst, Clin Trop Med, Brisbane, Qld, Australia. [Gatton, Michelle L.] Queensland Univ Technol, Sch Publ Hlth & Social Work, Brisbane, Qld 4001, Australia. [Waters, Norman C.] Walter Reed Army Inst Res, Malaria Vaccine Branch, Mil Malaria Res Program, Silver Spring, MD USA. RP Peatey, CL (reprint author), Australian Army Malaria Inst, Enoggera, Qld 4053, Australia. EM christopher.peatey@defence.gov.au FU National Health and Medical Research Council of Australia [1021273] FX This work was supported by the National Health and Medical Research Council of Australia (grant 1021273). NR 35 TC 7 Z9 7 U1 1 U2 11 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD AUG 1 PY 2015 VL 212 IS 3 BP 426 EP 434 DI 10.1093/infdis/jiv048 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA CM6TY UT WOS:000357824300012 PM 25635122 ER PT J AU Agha, M Lovich, JE Ennen, JR Augustine, B Arundel, TR Murphy, MO Meyer-Wilkins, K Bjurlin, C Delaney, D Briggs, J Austin, M Madrak, SV Price, SJ AF Agha, Mickey Lovich, Jeffrey E. Ennen, Joshua R. Augustine, Benjamin Arundel, Terence R. Murphy, Mason O. Meyer-Wilkins, Kathie Bjurlin, Curtis Delaney, David Briggs, Jessica Austin, Meaghan Madrak, Sheila V. Price, Steven J. TI Turbines and Terrestrial Vertebrates: Variation in Tortoise Survivorship Between a Wind Energy Facility and an Adjacent Undisturbed Wildland Area in the Desert Southwest (USA) SO ENVIRONMENTAL MANAGEMENT LA English DT Article DE Activity center; Desert tortoise; Gopherus agassizii; Landscape disturbance; Renewable energy ID GOPHERUS-AGASSIZII; MOJAVE DESERT; HOME-RANGE; WILDLIFE CONSERVATION; SOUTHERN CALIFORNIA; CLIMATIC VARIATION; PALM SPRINGS; POPULATIONS; IMPACTS; MORTALITY AB With the recent increase in utility-scale wind energy development, researchers have become increasingly concerned how this activity will affect wildlife and their habitat. To understand the potential impacts of wind energy facilities (WEF) post-construction (i.e., operation and maintenance) on wildlife, we compared differences in activity centers and survivorship of Agassiz's desert tortoises (Gopherus agassizii) inside or near a WEF to neighboring tortoises living near a wilderness area (NWA) and farther from the WEF. We found that the size of tortoise activity centers varied, but not significantly so, between the WEF (6.25 +/- A 2.13 ha) and adjacent NWA (4.13 +/- A 1.23 ha). However, apparent survival did differ significantly between the habitat types: over the 18-year study period apparent annual survival estimates were 0.96 +/- A 0.01 for WEF tortoises and 0.92 +/- A 0.02 for tortoises in the NWA. High annual survival suggests that operation and maintenance of the WEF has not caused considerable declines in the adult population over the past two decades. Low traffic volume, enhanced resource availability, and decreased predator populations may influence annual survivorship at this WEF. Further research on these proximate mechanisms and population recruitment would be useful for mitigating and managing post-development impacts of utility-scale wind energy on long-lived terrestrial vertebrates. C1 [Agha, Mickey; Price, Steven J.] Univ Kentucky, Dept Forestry, Lexington, KY 40546 USA. [Lovich, Jeffrey E.; Arundel, Terence R.; Austin, Meaghan] US Geol Survey, Southwest Biol Sci Ctr, Flagstaff, AZ 86001 USA. [Ennen, Joshua R.] Tennessee Aquarium Conservat Inst, Chattanooga, TN 37402 USA. [Augustine, Benjamin] Virginia Tech, Dept Fish & Wildlife Conservat, Blacksburg, VA 24061 USA. [Murphy, Mason O.] Univ Kentucky, Dept Biol, Lexington, KY 40506 USA. [Bjurlin, Curtis] Stantec Consulting, Cottage Grove, WI 53527 USA. [Delaney, David] US Army Construct Engn Res Lab, Champaign, IL 61826 USA. [Briggs, Jessica] Colorado State Univ, Warner Coll Nat Resources, Ft Collins, CO 80523 USA. [Madrak, Sheila V.] San Diego State Univ, Dept Biol, San Diego, CA 92182 USA. RP Price, SJ (reprint author), Univ Kentucky, Dept Forestry, Lexington, KY 40546 USA. EM mickey.agha@uky.edu; jeffrey_lovich@usgs.gov; jre@tnaqua.org; ben.augustine@uky.edu; tarundel@usgs.gov; mason.murphy@uky.edu; dirtgirl@me.com; curtbjurlin@gmail.com; david.delaney@usace.army.mil; meaghan.liszewski@gmail.com; svmadrak@gmail.com; steven.price@uky.edu OI Lovich, Jeffrey/0000-0002-7789-2831; Agha, Mickey/0000-0003-0961-8344 FU California Energy Commission Public Interest Energy Research Program [500-09-020]; California Desert District Office of the Bureau of Land Management; Desert Legacy Fund of the California Desert Research Program; University of Kentucky, Department of Forestry FX Our research was supported by the California Energy Commission Public Interest Energy Research Program (Contract NO: 500-09-020), the California Desert District Office of the Bureau of Land Management, and the Desert Legacy Fund of the California Desert Research Program, and University of Kentucky, Department of Forestry. Research was conducted under permits from the United States Fish and Wildlife Service, California Department of Fish and Game, and the Bureau of Land Management. Charles Yackulic, Jeff Laake and Simon Bonner provided statistical advice. Early manuscript reviews were conducted by Kenneth E. Nussear. Special thanks are given to A. Muth of the Boyd Deep Canyon Desert Research Center of the University of California, Riverside, for providing accommodations during our research. Any use of trade, product, or firm names is for descriptive purposes only and does not imply endorsement by the U.S. Government. NR 87 TC 0 Z9 0 U1 3 U2 30 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0364-152X EI 1432-1009 J9 ENVIRON MANAGE JI Environ. Manage. PD AUG PY 2015 VL 56 IS 2 BP 332 EP 341 DI 10.1007/s00267-015-0498-9 PG 10 WC Environmental Sciences SC Environmental Sciences & Ecology GA CL9FE UT WOS:000357280500004 PM 25894273 ER PT J AU Cerco, CF AF Cerco, Carl F. TI A Multi-module Approach to Calculation of Oyster (Crassostrea virginica) Environmental Benefits SO ENVIRONMENTAL MANAGEMENT LA English DT Article DE Oyster benefits; Bivalve bioenergetics; Environmental models; Great Wicomico River; Chesapeake Bay ID CHESAPEAKE BAY; WATER-QUALITY; ECOSYSTEM SERVICE; EASTERN OYSTER; MODEL; RESTORATION; RIVER; EUTROPHICATION; FILTRATION; GMELIN AB Environmental benefits are one of the motivations for management restoration of depleted bivalve populations. We describe a series of linked modules for benefits calculation. The modules include: oyster (Crassostrea virginica) bioenergetics, materials transport via the tidal prism, and benefits quantification. Quantified benefits include carbon, nitrogen, and phosphorus removal and shell production. The modules are demonstrated through application to the Great Wicomico River, a tributary of Chesapeake Bay, USA. Oysters on seven reefs (total area 2.8 x 10(5) m(2)) are calculated to remove 15.2, 6.2, and 0.2 tons per annum of carbon, nitrogen, and phosphorus, respectively, from the Great Wicomico. Oyster mortality contributes 108 tons per annum dry weight shell to the reefs. C1 US Army Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Cerco, CF (reprint author), US Army Engn Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM carl.f.cerco@usace.army.mil FU US Army Corps of Engineers System-Wide Water Resources Program; Ecosystem Management and Restoration Research Program FX Portions of this study were funded by the US Army Corps of Engineers System-Wide Water Resources Program and the Ecosystem Management and Restoration Research Program. NR 29 TC 0 Z9 0 U1 7 U2 18 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0364-152X EI 1432-1009 J9 ENVIRON MANAGE JI Environ. Manage. PD AUG PY 2015 VL 56 IS 2 BP 467 EP 479 DI 10.1007/s00267-015-0511-3 PG 13 WC Environmental Sciences SC Environmental Sciences & Ecology GA CL9FE UT WOS:000357280500013 PM 25924786 ER PT J AU Kardouni, JR Shaffer, SW Pidcoe, PE Finucane, SD Cheatham, SA Michener, LA AF Kardouni, Joseph R. Shaffer, Scott W. Pidcoe, Peter E. Finucane, Sheryl D. Cheatham, Seth A. Michener, Lori A. TI Immediate changes in pressure pain sensitivity after thoracic spinal manipulative therapy in patients with subacromial impingement syndrome: A randomized controlled study SO MANUAL THERAPY LA English DT Article DE Subacromial impingement; Thoracic manipulation; Pressure pain threshold ID MECHANICAL NECK PAIN; THRUST MANIPULATION; SHOULDER PAIN; CONTROLLED-TRIAL; EXPECTATIONS; RELIABILITY; THRESHOLD; OUTCOMES; WOMEN AB Background: Thoracic SMT can improve symptoms in patients with subacromial impingement syndrome. However, at this time the mechanisms of SMT are not well established. It is possible that changes in pain sensitivity may occur following SMT. Objectives: To assess the immediate pain response in patients with shoulder pain following thoracic spinal manipulative therapy (SMT) using pressure pain threshold (PPT), and to assess the relationship of change in pain sensitivity to patient-rated outcomes of pain and function following treatment. Design: Randomized Controlled Study. Methods: Subjects with unilateral subacromial impingement syndrome (n = 45) were randomly assigned to receive treatment with thoracic SMT or sham thoracic SMT. PPT was measured at the painful shoulder (deltoid) and unaffected regions (contralateral deltoid and bilateral lower trapezius areas) immediately pre- and post-treatment. Patient-rated outcomes were pain (numeric pain rating scale NPRS), function (Pennsylvania Shoulder Score - Penn), and global rating of change (GROC). Results: There were no significant differences between groups in pre-to post-treatment changes in PPT (p >= 0.583) nor were there significant changes in PPT within either group (p >= 0.372) following treatment. NPRS, Penn and GROC improved across both groups (p < 0.001), but there were no differences between the groups (p >= 0.574). Conclusion: There were no differences in pressure pain sensitivity between participants receiving thoracic SMT versus sham thoracic SMT. Both groups had improved patient-rated pain and function within 24-48 h of treatment, but there was no difference in outcomes between the groups. Published by Elsevier Ltd. C1 [Kardouni, Joseph R.] US Army Res Inst Environm Med, Total Army Injury & Hlth Outcomes Database TAIHOD, Natick, MA 01760 USA. [Shaffer, Scott W.] US Army Baylor Univ Doctoral Program Phys Therapy, Ft Sam Houston, TX USA. [Pidcoe, Peter E.; Finucane, Sheryl D.] Virginia Commonwealth Univ, Dept Phys Therapy, Richmond, VA USA. [Cheatham, Seth A.] Virginia Commonwealth Univ, Med Ctr, Dept Orthopaed Surg, Richmond, VA USA. [Michener, Lori A.] Univ So Calif, Div Biokinesiol & Phys Therapy, Los Angeles, CA USA. RP Kardouni, JR (reprint author), US Army Res Inst Environm Med, Mil Performance Div, 15 Kansas St,Bldg 42, Natick, MA 01760 USA. EM joseph.r.kardouni.mil@mail.mil OI Kardouni, Joseph/0000-0002-1948-045X FU Clinical and Translational Science Award from the National Center for Advancing Translational Sciences [UL1TR000058]; AD Williams' Fund of the Virginia Commonwealth University FX This research was funded through Clinical and Translational Science Award No. UL1TR000058 from the National Center for Advancing Translational Sciences and the AD Williams' Fund of the Virginia Commonwealth University. The authors certify that they have no affiliations with or financial involvement in any organization or entity with a direct financial interest in this study. NR 30 TC 5 Z9 5 U1 1 U2 6 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND SN 1356-689X EI 1532-2769 J9 MANUAL THER JI Man. Ther. PD AUG PY 2015 VL 20 IS 4 BP 540 EP 546 DI 10.1016/j.math.2014.12.003 PG 7 WC Rehabilitation SC Rehabilitation GA CM0EV UT WOS:000357352100004 PM 25595413 ER PT J AU Anantharaman, H Shunmugasamy, VC Strbik, OM Gupta, N Cho, K AF Anantharaman, Harish Shunmugasamy, Vasanth Chakravarthy Strbik, Oliver M., III Gupta, Nikhil Cho, Kyu TI Dynamic properties of silicon carbide hollow particle filled magnesium alloy (AZ91D) matrix syntactic foams SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE High strain rate testing; Syntactic foam; Metal foam; Dynamic mechanical Analysis ID HIGH-STRAIN RATES; COMPRESSIVE PROPERTIES; HEAT-TREATMENT; MECHANICAL-PROPERTIES; DAMPING BEHAVIOR; COMPOSITE FOAMS; MICROSTRUCTURE; FABRICATION; FREQUENCY; CORROSION AB Metal matrix syntactic foams of very low density (0.97 g/cc) were prepared using silicon carbide hollow particles dispersed in a magnesium alloy (AZ91D) matrix. The composite was evaluated for quasi-static and high strain rate (1330-2300/s) compression and dynamic mechanical properties. The compression test results show that the peak stress and the elastic energy absorbed were strain rate sensitive and the values at high strain rates were up to 1.5 times higher than the quasi-static values. The failure mechanisms of syntactic foams at high strain rates were observed to be failure of the hollow particles, plastic deformation of the matrix and fracture of precipitates that are oriented along the grain boundaries of the alloy. Extensive dynamic mechanical analysis was conducted under the conditions of (a) temperature variation at a constant frequency and (b) frequency variation over a wide range of temperatures to conduct time-temperature superposition (TTS). The damping parameter of the composites was observed to be higher than those of the matrix alloy at all temperatures. The TTS principle allowed extrapolating the material behavior over a wide frequency range from a limited frequency dataset range of 1-100 Hz. Such very low density syntactic foams can be useful in marine vessel and aerospace structures for weight saving. In addition, composites in this density range can directly compete with polymer matrix composites with added advantage of dimensional stability and mechanical property retention at higher temperatures. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Anantharaman, Harish; Shunmugasamy, Vasanth Chakravarthy; Gupta, Nikhil] NYU, Polytech Sch Engn, Dept Mech & Aerosp Engn, Composite Mat & Mech Lab, Brooklyn, NY 11201 USA. [Strbik, Oliver M., III] Deep Springs Technol LLC, Toledo, OH 43615 USA. [Cho, Kyu] US Army, Res Lab, RDRL WMM D, Aberdeen Proving Ground, MD 21005 USA. RP Gupta, N (reprint author), NYU, Polytech Sch Engn, Dept Mech & Aerosp Engn, Composite Mat & Mech Lab, Brooklyn, NY 11201 USA. EM ngupta@nyu.edu RI Shunmugasamy, Vasanth Chakravarthy/P-8618-2016; OI Shunmugasamy, Vasanth Chakravarthy/0000-0003-4818-004X; gupta, nikhil/0000-0001-7128-4459 FU U.S. Army Research Laboratory of DST [W911NF-10-2-0084]; NYU [W911NF-11-2-0096] FX This research is sponsored by the U.S. Army Research Laboratory contract W911NF-10-2-0084 of DST and the Cooperative Agreement W911NF-11-2-0096 with NYU. The Mechanical and Aerospace Engineering Department at NYU is acknowledged for providing facilities. Steven E. Zeltmann is thanked for help in manuscript preparation. NR 47 TC 7 Z9 8 U1 3 U2 21 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X EI 1879-3509 J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD AUG PY 2015 VL 82 SI SI BP 14 EP 24 DI 10.1016/j.ijimpeng.2015.04.008 PG 11 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA CL8OI UT WOS:000357233600004 ER PT J AU Howell, R Van Aken, DC AF Howell, Ryan A. Van Aken, David C. TI Microstructural and Fracture Behavior of Phosphorus-Containing Fe-30Mn-9Al-1Si-0.9C-0.5Mo Alloy Steel SO METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE LA English DT Article AB Five different phosphorus (P)-containing heat-treated Fe-Mn-Al-C alloys were tested in accordance with ASTM E 23 Charpy V-notch Energy (CVNE) standards. Room temperature CVNE of solution treated and quenched specimens revealed ductile fracture for 0.001 and 0.006 wt pct (pct P-containing alloys). Brittle cleavage fracture dominated the 0.043 and 0.07 pct P-containing alloys. A hard brittle P eutectic phase was observed in the 0.07 pct P-containing alloy. (C) The Minerals, Metals & Materials Society and ASM International (outside the USA) 2015 C1 [Howell, Ryan A.] US Army, Army Res Lab, Weap & Mat, Aberdeen Proving Ground, MD 21005 USA. [Van Aken, David C.] Missouri Univ Sci & Technol, Dept Mat Sci & Engn, Rolla, MO 65409 USA. RP Howell, R (reprint author), US Army, Army Res Lab, Weap & Mat, Aberdeen Proving Ground, MD 21005 USA. EM ryan.a.howell2.mil@mail.mil; dcva@mst.edu FU Army Research Laboratory FX This research was funded by the Army Research Laboratory. NR 12 TC 1 Z9 1 U1 3 U2 8 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1073-5623 EI 1543-1940 J9 METALL MATER TRANS A JI Metall. Mater. Trans. A-Phys. Metall. Mater. Sci. PD AUG PY 2015 VL 46A IS 8 BP 3309 EP 3316 DI 10.1007/s11661-015-2971-8 PG 8 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA CL1TQ UT WOS:000356728100001 ER PT J AU Hickey, JT Huff, R Dunn, CN AF Hickey, John T. Huff, Rochelle Dunn, Christopher N. TI Using habitat to quantify ecological effects of restoration and water management alternatives SO ENVIRONMENTAL MODELLING & SOFTWARE LA English DT Article DE HEC-EFM; Ecosystem Functions Model; Ecosystem restoration; Water resources planning; Flow-ecology relationships; Hydrologic Engineering Center ID ENVIRONMENTAL FLOWS; RIPARIAN VEGETATION; RIVER; ESTABLISHMENT; STREAMFLOW; REGIMES; FLOODS; TEXAS AB The Ecosystem Functions Model (HEC-EFM) is designed to help study teams determine ecosystem responses to changes in the flow regime of a river or connected wetland. HEC-EFM analyses involve: 1) statistical analyses of relationships between hydrology and ecology, 2) hydraulic modeling, and 3) use of Geographic Information Systems (GIS). Through this process, study teams define existing ecologic conditions, highlight promising restoration sites, and assess alternatives according to predicted ecosystem changes. HEC-EFM has many strengths, most notably it 1) is capable of testing change for many ecological relationships and management scenarios, 2) links ecology with established hydrologic, hydraulic, and GIS tools, and 3) can be applied quickly, inexpensively, and can incorporate expert knowledge. This paper introduces HEC-EFM and describes its use for statistical analyses and habitat mapping. Two examples are provided: Provision of Sacramento splittail minnow spawning habitat, San Joaquin River, California, USA, and cottonwood seedling establishment, Bill Williams River, Arizona, USA. Published by Elsevier Ltd. C1 [Hickey, John T.; Dunn, Christopher N.] US Army, Hydrol Engn Ctr, Corps Engn, Davis, CA 95616 USA. [Huff, Rochelle] David Ford Consulting Engn Inc, Sacramento, CA 95811 USA. RP Hickey, JT (reprint author), US Army, Hydrol Engn Ctr, Corps Engn, 609 2nd St, Davis, CA 95616 USA. EM john.hickey@usace.army.mil; rhuff@ford-consulting.com; christopher.dunn@usace.army.mil NR 46 TC 2 Z9 2 U1 5 U2 55 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1364-8152 EI 1873-6726 J9 ENVIRON MODELL SOFTW JI Environ. Modell. Softw. PD AUG PY 2015 VL 70 BP 16 EP 31 DI 10.1016/j.envsoft.2015.03.012 PG 16 WC Computer Science, Interdisciplinary Applications; Engineering, Environmental; Environmental Sciences SC Computer Science; Engineering; Environmental Sciences & Ecology GA CL1YR UT WOS:000356741300002 ER PT J AU LaBarre, ED Calderon-Colon, X Morris, M Tiffany, J Wetzel, E Merkle, A Trexler, M AF LaBarre, E. D. Calderon-Colon, X. Morris, M. Tiffany, J. Wetzel, E. Merkle, A. Trexler, M. TI Effect of a carbon nanotube coating on friction and impact performance of Kevlar SO JOURNAL OF MATERIALS SCIENCE LA English DT Article ID BALLISTIC IMPACT; HIGH-STRENGTH; FABRICS; YARN; MECHANISMS; BEHAVIOR; ENERGY AB Because surface treatments of high-performance fibers have previously resulted in increased friction and improved impact performance, it was of interest to evaluate the influence of multi-walled carbon nanotubes (MWNTs) on impact performance and contributing constituent properties of Kevlar. Kevlar K129 yarns and fabrics were modified via sonication in a solution of N-methylpyrrolidone (NMP) and MWNTs. This method has the potential to both improve the intrinsic properties of the fibers themselves as well as increase the friction, with very low mass addition. Tensile, static friction, and pull-out tests were performed to compare the properties of MWNT-treated materials to neat. As a result of MWNT augmentation, yarn modulus increased up to 15 %, and static and kinetic friction coefficients increased up to 30 %. Yarn pull-out tests revealed up to a 230 % increase in the forces required to pull-out yarns. To study the effects of MWNT augmentation on dynamic performance, low-velocity impact tests of steel spheres on a single ply of fabric were performed. These experiments demonstrated approximately 50 % increase in ballistic limit for MWNT-treated Kevlar with negligible (0.4-1.4 %) increase in mass. Entanglement among MWNTs along with increased surface roughness and surface area increased the resistance to motion, improving impact performance by increasing the energy required to pull-out yarns from the textile, while inhibiting textile windowing and driving a larger number of yarn failures. The observed changes in fabric response suggest that MWNT treatments have the potential to improve the ballistic limit of fabrics through increased interfilament and interyarn friction without compromising fiber strength or adding significant mass. C1 [LaBarre, E. D.; Calderon-Colon, X.; Morris, M.; Tiffany, J.; Merkle, A.; Trexler, M.] Johns Hopkins Univ, Appl Phys Lab, Laurel, MD 20723 USA. [Wetzel, E.] US Army Res Lab, Weap & Mat Res Directorate, Adelphi, MD 21005 USA. RP Trexler, M (reprint author), Johns Hopkins Univ, Appl Phys Lab, 11100 Johns Hopkins Rd, Laurel, MD 20723 USA. EM erin.labarre@jhuapl.edu; xiomara.calderon-colon@jhuapl.edu; melanie.morris@jhuapl.edu; jason.tiffany@jhuapl.edu; eric.d.wetzel2.civ@mail.mil; andrew.merkle@jhuapl.edu; morgana.trexler@jhuapl.edu FU Office of Naval Research [N00014-12-1-0402]; Johns Hopkins University Applied Physics Laboratory Research and Exploratory Development Mission Area; Janney Publication by the Johns Hopkins University Applied Physics Laboratory FX This work was funded in part by the Office of Naval Research Award Number N00014-12-1-0402. The authors acknowledge support from the Johns Hopkins University Applied Physics Laboratory Research and Exploratory Development Mission Area under independent research and development funds. The authors would also like to acknowledge funding from a Janney Publication Award provided by the Johns Hopkins University Applied Physics Laboratory. We would also like to thank Larry Long at the Army Research Laboratory for assistance in performing impact experiments. NR 30 TC 0 Z9 0 U1 7 U2 69 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0022-2461 EI 1573-4803 J9 J MATER SCI JI J. Mater. Sci. PD AUG PY 2015 VL 50 IS 16 BP 5431 EP 5442 DI 10.1007/s10853-015-9088-8 PG 12 WC Materials Science, Multidisciplinary SC Materials Science GA CJ6VH UT WOS:000355632500008 ER PT J AU Morelock, JD AF Morelock, Jerry D. TI 'I'm going to command the whole shebang' SO AMERICAN HISTORY LA English DT Article C1 US Army Command & Gen Staff Coll, Dept Hist, Ft Leavenworth, KS 66027 USA. RP Morelock, JD (reprint author), US Army Command & Gen Staff Coll, Dept Hist, Ft Leavenworth, KS 66027 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WEIDER HIST GRP INC PI LEESBURG PA 741 MILLER DR SE, STE D-2, LEESBURG, VA 20175 USA SN 1076-8866 J9 AM HIST JI Am. Hist. PD AUG PY 2015 VL 50 IS 3 SI SI BP 38 EP 44 PG 7 WC History SC History GA CI4XK UT WOS:000354757000019 ER PT J AU Sun, XX Nasrabadi, NM Tran, TD AF Sun, Xiaoxia Nasrabadi, Nasser M. Tran, Trac D. TI Task-Driven Dictionary Learning for Hyperspectral Image Classification With Structured Sparsity Constraints SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article DE Hyperspectral imagery (HSI) classification; joint sparsity (JS); Laplacian sparsity; sparse representation; supervised dictionary learning; task-driven dictionary learning (TDDL) ID MULTIPLE-MEASUREMENT VECTORS; LINEAR INVERSE PROBLEMS; REPRESENTATION; ALGORITHM AB Sparse representation models a signal as a linear combination of a small number of dictionary atoms. As a generative model, it requires the dictionary to be highly redundant in order to ensure both a stable high sparsity level and a low reconstruction error for the signal. However, in practice, this requirement is usually impaired by the lack of labeled training samples. Fortunately, previous research has shown that the requirement for a redundant dictionary can be less rigorous if simultaneous sparse approximation is employed, which can be carried out by enforcing various structured sparsity constraints on the sparse codes of the neighboring pixels. In addition, numerous works have shown that applying a variety of dictionary learning methods for the sparse representation model can also improve the classification performance. In this paper, we highlight the task-driven dictionary learning (TDDL) algorithm, which is a general framework for the supervised dictionary learning method. We propose to enforce structured sparsity priors on the TDDL method in order to improve the performance of the hyperspectral classification. Our approach is able to benefit from both the advantages of the simultaneous sparse representation and those of the supervised dictionary learning. We enforce two different structured sparsity priors, the joint and Laplacian sparsities, on the TDDL method and provide the details of the corresponding optimization algorithms. Experiments on numerous popular hyperspectral images demonstrate that the classification performance of our approach is superior to that of the sparse representation classifier with structured priors or the TDDL method. C1 [Sun, Xiaoxia; Tran, Trac D.] Johns Hopkins Univ, Dept Elect & Comp Engn, Baltimore, MD 21218 USA. [Nasrabadi, Nasser M.] US Army Res Lab, Adelphi, MD 20783 USA. RP Sun, XX (reprint author), Johns Hopkins Univ, Dept Elect & Comp Engn, Baltimore, MD 21218 USA. EM xsun9@jhu.edu; nnasraba@arl.army.mil; trac@jhu.edu FU National Science Foundation [CCF-1117545]; Army Research Office [60219-MA]; Office of Naval Research [N000141210765] FX This work was supported in part by the National Science Foundation under Grant CCF-1117545, by the Army Research Office under Grant 60219-MA, and by the Office of Naval Research under Grant N000141210765. NR 45 TC 11 Z9 12 U1 2 U2 27 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0196-2892 EI 1558-0644 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD AUG PY 2015 VL 53 IS 8 BP 4457 EP 4471 DI 10.1109/TGRS.2015.2399978 PG 15 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA CE3XQ UT WOS:000351763800025 ER PT J AU Austin, KG Price, LL McGraw, SM Lieberman, HR AF Austin, Krista G. Price, Lori Lyn McGraw, Susan M. Lieberman, Harris R. TI Predictors of Dietary Supplement Use by US Coast Guard Personnel SO PLOS ONE LA English DT Article ID ARMY SOLDIERS AB Background Personnel in Armed Forces entities such as the US Coast Guard (USCG) engage in strenuous tasks requiring high levels of physiological and psychological fitness. Previous reports have found increased prevalence of dietary supplement (DS) use by military personnel to meet the demands of their occupation. Objective This study assessed DS prevalence and patterns of use in USCG personnel and compared these findings to reports from other Armed Forces personnel. Design Use of DS by USCG personnel (n = 1059) was assessed by survey at USCG installations. Data were weighted by age, sex, and rank to be representative of total USCG demographics. Results Seventy percent of USCG personnel reported using a DS at least 1 time/wk. Thirty-three percent used 1-2 DS >= 1 time/wk, 18% 3-4 DS >= 1 time/wk, and almost 19% >= 5 DS >= 1 time/wk. Average expenditure on DSs by UCSG personnel was $40/mo. More than 47% of USCG personnel used a multivitamin and mineral, 33% consumed protein supplements, 22% used individual vitamins and minerals, 23% reported taking combination products, and 9% consumed herbal supplements. Increased use of DS use was associated with high intensity operational occupations, participating in high volumes of aerobic exercise and strength training. Use of DS was not associated with age, education or body mass index. Conclusion Occupation is an important determinate of DS use. Prevalence of DS use by USCG personnel is greater than reported for other Armed Forces personnel and reflects high levels of participation in aerobic and strength training activities. C1 [Austin, Krista G.; McGraw, Susan M.; Lieberman, Harris R.] US Army, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. [Austin, Krista G.] Oak Ridge Inst Sci & Educ, Belcamp, MD 21017 USA. [Price, Lori Lyn] Tufts Univ, Inst Clin Res & Hlth Policy Studies, Tufts Med Ctr, Tufts Clin & Translat Sci Inst, Boston, MA 02111 USA. RP Lieberman, HR (reprint author), US Army, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. EM harris.r.lieberman.civ@mail.mil FU United States Army Medical Research and Material Command (USAMRMC); Department of Defense Center Alliance for Dietary Supplement Research FX This work was supported by the United States Army Medical Research and Material Command (USAMRMC) and the Department of Defense Center Alliance for Dietary Supplement Research. NR 28 TC 1 Z9 1 U1 0 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUL 31 PY 2015 VL 10 IS 7 AR e0133006 DI 10.1371/journal.pone.0133006 PG 15 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CO0JY UT WOS:000358838400024 PM 26230407 ER PT J AU Wilkerson, RC Linton, YM Fonseca, DM Schultz, TR Price, DC Strickman, DA AF Wilkerson, Richard C. Linton, Yvonne-Marie Fonseca, Dina M. Schultz, Ted R. Price, Dana C. Strickman, Daniel A. TI Making Mosquito Taxonomy Useful: A Stable Classification of Tribe Aedini that Balances Utility with Current Knowledge of Evolutionary Relationships SO PLOS ONE LA English DT Article ID RIFT-VALLEY FEVER; EASTERN EQUINE ENCEPHALITIS; ALLIED TAXA DIPTERA; PHYLOGENETIC-RELATIONSHIPS; YELLOW-FEVER; LIFE STAGES; ARBOVIRUS SURVEILLANCE; WUCHERERIA-BANCROFTI; MORPHOLOGICAL DATA; CULICIDAE DIPTERA AB The tribe Aedini (Family Culicidae) contains approximately one-quarter of the known species of mosquitoes, including vectors of deadly or debilitating disease agents. This tribe contains the genus Aedes, which is one of the three most familiar genera of mosquitoes. During the past decade, Aedini has been the focus of a series of extensive morphology-based phylogenetic studies published by Reinert, Harbach, and Kitching (RH&K). Those authors created 74 new, elevated or resurrected genera from what had been the single genus Aedes, almost tripling the number of genera in the entire family Culicidae. The proposed classification is based on subjective assessments of the "number and nature of the characters that support the branches" subtending particular monophyletic groups in the results of cladistic analyses of a large set of morphological characters of representative species. To gauge the stability of RH&K's generic groupings we reanalyzed their data with unweighted parsimony jackknife and maximum-parsimony analyses, with and without ordering 14 of the characters as in RH&K. We found that their phylogeny was largely weakly supported and their taxonomic rankings failed priority and other useful taxon-naming criteria. Consequently, we propose simplified aedine generic designations that 1) restore a classification system that is useful for the operational community; 2) enhance the ability of taxonomists to accurately place new species into genera; 3) maintain the progress toward a natural classification based on monophyletic groups of species; and 4) correct the current classification system that is subject to instability as new species are described and existing species more thoroughly defined. We do not challenge the phylogenetic hypotheses generated by the above-mentioned series of morphological studies. However, we reduce the ranks of the genera and subgenera of RH&K to subgenera or informal species groups, respectively, to preserve stability as new data become available. C1 [Wilkerson, Richard C.; Linton, Yvonne-Marie; Schultz, Ted R.] Smithsonian Inst, Dept Entomol, Natl Museum Nat Hist, Washington, DC 20560 USA. [Linton, Yvonne-Marie] Smithsonian Inst, Museum Support Ctr, Walter Reed Biosystemat Unit, Suitland, MD USA. [Linton, Yvonne-Marie] Walter Reed Army Inst Res, Dept Entomol, Silver Spring, MD USA. [Linton, Yvonne-Marie] Uniformed Serv Univ Hlth Sci, Fac Preventat Med & Biometr, Bethesda, MD 20814 USA. [Fonseca, Dina M.; Price, Dana C.] Rutgers State Univ, Dept Entomol, Sch Environm & Biol Sci, New Brunswick, NJ 08903 USA. [Strickman, Daniel A.] Bill & Melinda Gates Fdn, Global Hlth Program, Seattle, WA USA. RP Wilkerson, RC (reprint author), Smithsonian Inst, Dept Entomol, Natl Museum Nat Hist, NHB 169, Washington, DC 20560 USA. EM wilkersonr@si.edu OI Fonseca, Dina/0000-0003-4726-7100 NR 104 TC 32 Z9 34 U1 4 U2 15 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUL 30 PY 2015 VL 10 IS 7 AR e0133602 DI 10.1371/journal.pone.0133602 PG 26 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CO0JT UT WOS:000358837700027 PM 26226613 ER PT J AU Bridewell, VL Alam, R Karwacki, CJ Kamat, PV AF Bridewell, Victoria L. Alam, Rabeka Karwacki, Christopher J. Kamat, Prashant V. TI CdSe/CdS Nanorod Photocatalysts: Tuning the Interfacial Charge Transfer Process through Shell Length SO CHEMISTRY OF MATERIALS LA English DT Article ID SEMICONDUCTOR NANOCRYSTALS; METHYL VIOLOGEN; ENERGY-TRANSFER; DYNAMICS; HETEROSTRUCTURES; NANOPARTICLES; GENERATION; RELAXATION; MORPHOLOGY; REDUCTION AB CdSe/CdS core/shell semiconductor ramrods (NR) with rod-in-rod morphology offer new strategies for designing highly emissive nanostructures. The interplay between energetically matched semiconductors results in enhanced emission from the CdSe core. In order to further evaluate the cooperative role of these two semiconductors in a core/shell geometry, we have probed the photoinduced charge transfer between CdSe/CdS core/shell semiconductor NR and methyl viologen (MV2+). The quenching of the emission by the electron acceptor, MV2+, as well as the production of electron transfer product MV center dot+ depends on the aspect ratio (l/w) of the NR thus pointing out the role of CdS shell in determining the overall photo catalytic efficiency. Transient absorption measurements show that the presence of MV2+ influences only the bleaching recovery of the CdS shell and not of the CdSe core recovery. Thus, optimization of shell aspect ratio plays a crucial role in maximizing the efficiency of this photocatalytic system. C1 [Bridewell, Victoria L.; Alam, Rabeka; Kamat, Prashant V.] Univ Notre Dame, Notre Dame Radiat Lab, Notre Dame, IN 46556 USA. [Bridewell, Victoria L.; Kamat, Prashant V.] Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA. [Karwacki, Christopher J.] US Army Res, Dev & Engn Command, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Kamat, PV (reprint author), Univ Notre Dame, Notre Dame Radiat Lab, Notre Dame, IN 46556 USA. EM pkamat@nd.edu FU Army Research Office [ARO 64011-CH]; Division of Chemical Sciences, Geosciences, and Biosciences, Office of Basic Energy Sciences of the U.S. Department of Energy [DE-FC02-04ER15533] FX The research described in this paper is supported by the Army Research Office through the award ARO 64011-CH. This is a document number 5070 from the Notre Dame Radiation Laboratory, which is supported by the Division of Chemical Sciences, Geosciences, and Biosciences, Office of Basic Energy Sciences of the U.S. Department of Energy through award DE-FC02-04ER15533. NR 45 TC 21 Z9 21 U1 10 U2 70 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0897-4756 EI 1520-5002 J9 CHEM MATER JI Chem. Mat. PD JUL 28 PY 2015 VL 27 IS 14 BP 5064 EP 5071 DI 10.1021/acs.chemmater.5b01689 PG 8 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA CO0EN UT WOS:000358823000023 ER PT J AU Ettisserry, DP Goldsman, N Akturk, A Lelis, AJ AF Ettisserry, D. P. Goldsman, N. Akturk, A. Lelis, A. J. TI Negative bias-and-temperature stress-assisted activation of oxygen-vacancy hole traps in 4H-silicon carbide metal-oxide-semiconductor field-effect transistors SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID THRESHOLD-VOLTAGE INSTABILITY; SPIN-RESONANCE EVIDENCE; SIC POWER MOSFETS; AMORPHOUS SILICA; TIME-DEPENDENCE; RELIABILITY; MODEL; SIO2; DYNAMICS; GENERATION AB We use hybrid-functional density functional theory-based Charge Transition Levels (CTLs) to study the electrical activity of near-interfacial oxygen vacancies located in the oxide side of 4H-Silicon Carbide (4H-SiC) power Metal-Oxide-Semiconductor Field-Effect Transistors (MOSFETs). Based on the "amorphousness" of their local atomic environment, oxygen vacancies are shown to introduce their CTLs either within (permanently electrically active) or outside of (electrically inactive) the 4H-SiC bandgap. The "permanently electrically active" centers are likely to cause threshold voltage (V-th) instability at room temperature. On the other hand, we show that the "electrically inactive" defects could be transformed into various "electrically active" configurations under simultaneous application of negative bias and high temperature stresses. Based on this observation, we present a model for plausible oxygen vacancy defects that could be responsible for the recently observed excessive worsening of Vth instability in 4H-SiC power MOSFETs under high temperature-and-gate bias stress. This model could also explain the recent electrically detected magnetic resonance observations in 4H-SiC MOSFETs. (C) 2015 AIP Publishing LLC. C1 [Ettisserry, D. P.; Goldsman, N.; Akturk, A.] Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA. [Lelis, A. J.] US Army Res Lab, Adelphi, MD 20783 USA. RP Goldsman, N (reprint author), Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA. EM deva@umd.edu OI Ettisserry, Devanarayanan/0000-0002-4214-2141 NR 59 TC 1 Z9 1 U1 0 U2 22 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD JUL 28 PY 2015 VL 118 IS 4 AR 044507 DI 10.1063/1.4927619 PG 13 WC Physics, Applied SC Physics GA CO1PR UT WOS:000358928000044 ER PT J AU Chiang, CY Uzoma, I Lane, DJ Memisevic, V Alem, F Yao, K Kota, KP Bavari, S Wallqvist, A Hakami, RM Panchal, RG AF Chiang, Chih-Yuan Uzoma, Ijeoma Lane, Douglas J. Memisevic, Vesna Alem, Farhang Yao, Kuan Kota, Krishna P. Bavari, Sina Wallqvist, Anders Hakami, Ramin M. Panchal, Rekha G. TI A reverse-phase protein microarray-based screen identifies host signaling dynamics upon Burkholderia spp. infection SO FRONTIERS IN MICROBIOLOGY LA English DT Article DE Burkholderia mallei; Burkholderia pseudomallei; lipopolysaccharide; reverse-phase protein microarrays ID NF-KAPPA-B; NITRIC-OXIDE; PATHWAY ACTIVATION; ANTIMICROBIAL ACTIVITY; MURINE MACROPHAGES; MOUSE MACROPHAGES; INTERFERON-BETA; INNATE IMMUNITY; PSEUDOMALLEI; MELIOIDOSIS AB Burkholderia is a diverse genus of gram-negative bacteria that causes high mortality rate in humans, equines and cattle. The lack of effective therapeutic treatments poses serious public health threats. Developing insights toward host-Burkholderia spp. interaction is critical for understanding the pathogenesis of infection as well as identifying therapeutic targets for drug development. Reverse-phase protein microarray technology was previously proven to identify and characterize novel biomarkers and molecular signatures associated with infectious disease and cancer. In the present study, this technology was utilized to interrogate changes in host protein expression and phosphorylation events in macrophages infected with a collection of geographically diverse strains of Burkholderia spp. The expression or phosphorylation state of 25 proteins was altered during Burkholderia spp. infections of which eight proteins were selected for further characterization by immunoblotting. Increased phosphorylation of AMPK-al, Src, and GSK3 beta suggested the importance of their roles in regulating Burkholderia spp. mediated innate immune response. Modulating the inflammatory response by perturbing their activities may provide therapeutic routes for future treatments. C1 [Chiang, Chih-Yuan; Uzoma, Ijeoma; Lane, Douglas J.; Bavari, Sina; Panchal, Rekha G.] US Army Med Res Inst Infect Dis, Mol & Translat Sci Div, Frederick, MD 21702 USA. [Memisevic, Vesna; Wallqvist, Anders] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Dept Def Biotechnol, High Performance Comp Software Applicat Inst, Frederick, MD USA. [Alem, Farhang; Yao, Kuan; Hakami, Ramin M.] George Mason Univ, Natl Ctr Biodef & Infect Dis, Manassas, VA USA. [Alem, Farhang; Yao, Kuan; Hakami, Ramin M.] George Mason Univ, Sch Syst Biol, Manassas, VA USA. [Kota, Krishna P.] PerkinElmer Inc, Waltham, MA USA. RP Panchal, RG (reprint author), US Army Med Res Inst Infect Dis, Mol & Translat Sci Div, 1425 Porter St, Frederick, MD 21702 USA. EM rekha.g.panchal.civ@mail.mil OI wallqvist, anders/0000-0002-9775-7469 FU Department of Defense Chemical Biological Defense Program through the Defense Threat Reduction Agency (DTRA) [JSTO-CBS.MEDBIO.02.10.RD.010]; U.S. Army Medical Research and Materiel Command [W81XWH-11-P-0310]; George Mason University FX This project was funded by the Department of Defense Chemical Biological Defense Program through the Defense Threat Reduction Agency (DTRA) JSTO-CBS.MEDBIO.02.10.RD.010 (to RP), and by funding awarded by the U.S. Army Medical Research and Materiel Command (W81XWH-11-P-0310) and George Mason University (to RMH). We would like to thank Oak Ridge Institute for Science and Education for participating in the Postgraduate Research Program at the U.S. Army Medical Research and Materiel Command. We also thank Professor Emanuel F. Petricoin for invaluable advice regarding the RPMA data analysis and assistance with performance of the RPMA experiments. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. NR 51 TC 4 Z9 4 U1 0 U2 3 PU FRONTIERS MEDIA SA PI LAUSANNE PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLAND SN 1664-302X J9 FRONT MICROBIOL JI Front. Microbiol. PD JUL 27 PY 2015 VL 6 AR 683 DI 10.3389/fmicb.2015.00683 PG 13 WC Microbiology SC Microbiology GA CO0YY UT WOS:000358881100001 PM 26284031 ER PT J AU Kjelland, ME Piercy, CD Lackey, T Swannack, TM AF Kjelland, Michael E. Piercy, Candice D. Lackey, Tahirih Swannack, Todd M. TI An integrated modeling approach for elucidating the effects of different management strategies on Chesapeake Bay oyster metapopulation dynamics SO ECOLOGICAL MODELLING LA English DT Article DE Integrated environmental modeling; Oyster; Metapopulation; Spatially-explicit; Agent-based; Hydrodynamic ID NO-TAKE RESERVES; CRASSOSTREA-VIRGINICA; POPULATION-DYNAMICS; PERKINSUS-MARINUS; DEVELOP RESISTANCE; DERMO DISEASE; RESTORATION; DISPERSAL; REEFS; GROWTH AB Eastern oyster abundance is at an all-time low, yet this species is a key component of many estuarine systems because it contributes to ecosystem function by providing habitat, improving water quality, stabilizing benthic and intertidal habitat, increasing landscape diversity and producing more oysters. Given the breadth of environmental benefits oysters provide, as well as their commercial and cultural importance, sustainable oyster production has become a priority in several regions, including the Chesapeake Bay. Current strategies include treating restored reefs as permanent sanctuaries, which provide long-term environmental benefits yet removes them from the fishery, or harvesting reefs on a rotational basis, which provides economic value yet decreases environmental benefits. The long term dynamics of these strategies is unknown. Oysters have a complex, biphasic life cycle (i.e., sessile adult and motile larval stages) and their viability is intimately tied to a suite of environmental factors including, but not limited to, flow regime, total suspended solids, temperature, salinity, and dissolved oxygen. In order to determine how different oyster management strategies affect oyster dynamics, we developed a multi-model approach that integrates a 2-D hydrodynamic model, a larval transport model, and a spatially-explicit, agent-based population dynamics model to simulate long term oyster dynamics. We applied our model to a ten reef system in the Great Wicomico River in the Chesapeake Bay, and simulated six different combinations of sanctuary and/or harvest management scenarios over an 8-year period. We evaluated the environmental and commercial benefits of each strategy. Our results indicated that sanctuary reefs are beneficial, and that the spatial position of sanctuary reefs strongly affected source-sink dynamics and must be considered before implementing a harvest regime. Simulations that did not consider the source/sink dynamics of the reefs yielded larger numbers of oysters for harvest in the short-term, yet resulted in a complete fishery collapse in the long term. Selective, rotational harvest, resulted in lower annual yield, but the fishery persisted throughout the eight year simulation. This integrated modeling approach helped reduce uncertainty within the study system and can help natural resource managers understand ecosystem-level processes leading to more informed decision making across spatial and temporal scales. Published by Elsevier B.V. C1 [Kjelland, Michael E.; Piercy, Candice D.; Lackey, Tahirih; Swannack, Todd M.] US Army, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Swannack, Todd M.] SW Texas State Univ, Dept Biol, San Marcos, TX 78666 USA. RP Swannack, TM (reprint author), US Army, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM todd.m.swannack@usace.army.mil FU USACE-Norfolk District FX C. Cerco provided critical feedback during model development. C. Shepard and J. D. Westervelt provided code support. J. Coakley provided data for model evaluation. D. Hall, E. Lazarus, and T.W. Clumpkin provided thoughtful discussions on model development and presentation of results. This work was funded by the USACE-Norfolk District and their cost-sharing partner the Virginia Marine Resource Commission. NR 98 TC 3 Z9 3 U1 6 U2 49 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3800 EI 1872-7026 J9 ECOL MODEL JI Ecol. Model. PD JUL 24 PY 2015 VL 308 BP 45 EP 62 DI 10.1016/j.ecolmodel.2015.03.012 PG 18 WC Ecology SC Environmental Sciences & Ecology GA CJ7VL UT WOS:000355708400005 ER PT J AU Sviatenko, LK Gorb, L Hill, FC Leszczynska, D Leszczynski, J AF Sviatenko, Liudmyla K. Gorb, Leonid Hill, Frances C. Leszczynska, Danuta Leszczynski, Jerzy TI Structure and Redox Properties of 5-Amino-3-nitro-1H-1,2,4-triazole (ANTA) Adsorbed on a Silica Surface: A DFT M05 Computational Study SO JOURNAL OF PHYSICAL CHEMISTRY A LA English DT Article ID ELECTRON-DENSITY DISTRIBUTION; KAOLINITE SURFACES; CLAY-MINERALS; AB-INITIO; ADSORPTION; BOND; 1,3,5-TRINITROBENZENE; 2,4-DINITROTOLUENE; DERIVATIVES; POTENTIALS AB A cluster approximation was applied at the M05/tzvp level to model an adsorption of 5-amino-3-nitro-1H-1,2,4-triazole (ANTA) on the (001) surface of a-quartz. Structures of the obtained ANTA-silica complexes confirm a nearly parallel orientation of the nitro compound toward the surface. The atoms in molecules (AIM) method was applied to analyze binding between ANTA and the silica surface. Attachment or loss of an electron was found to lead to a significant deviation from coplanarity in the complexes and to a strengthening of a hydrogen bonding. Redox properties of the adsorbed ANTA were compared with those of gas-phase and hydrated species by calculation of the ionization potential, electron affinity, oxidation and reduction Gibbs free energies, and oxidation and reduction potentials. It was shown that the adsorbed ANTA has a lower ability to undergo redox transformations as compared to that of the hydrated one. C1 [Sviatenko, Liudmyla K.; Leszczynski, Jerzy] Jackson State Univ, Dept Chem & Biochem, Interdisciplinary Ctr Nanotox, Jackson, MS 39217 USA. [Sviatenko, Liudmyla K.] Oles Honchar Dnipropetrovsk Natl Univ, Dept Organ Chem, UA-49000 Dnepropetrovsk, Ukraine. [Gorb, Leonid] HX5 LLC, Vicksburg, MS 39180 USA. [Hill, Frances C.] US Army ERDC, Vicksburg, MS 39180 USA. [Leszczynska, Danuta] Jackson State Univ, Dept Civil & Environm Engn, Interdisciplinary Ctr Nanotox, Jackson, MS 39217 USA. RP Leszczynski, J (reprint author), Jackson State Univ, Dept Chem & Biochem, Interdisciplinary Ctr Nanotox, 1400 JR Lynch St, Jackson, MS 39217 USA. EM jerzy@icnanotox.org FU ERDC [W912HZ-13-P-0037]; Extreme Science and Engineering Discovery Environment (XSEDE) by National Science Foundation [OCI-1053575]; XSEDE Award Allocation [DMR110088] FX We thank ERDC for financial support (Grant W912HZ-13-P-0037). The computation time was provided by the Extreme Science and Engineering Discovery Environment (XSEDE) by National Science Foundation Grant OCI-1053575 and XSEDE Award Allocation DMR110088 and by the Mississippi Center for Supercomputer Research. NR 38 TC 2 Z9 2 U1 5 U2 16 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1089-5639 J9 J PHYS CHEM A JI J. Phys. Chem. A PD JUL 23 PY 2015 VL 119 IS 29 BP 8139 EP 8145 DI 10.1021/acs.jpca.5b03393 PG 7 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA CN7OP UT WOS:000358624200022 PM 26098296 ER PT J AU Devine, W Woodring, JL Swaminathan, U Amata, E Patel, G Erath, J Roncal, NE Lee, PJ Leed, SE Rodriguez, A Mensa-Wilmot, K Sciotti, RJ Pollastri, MP AF Devine, William Woodring, Jennifer L. Swaminathan, Uma Amata, Emanuele Patel, Gautam Erath, Jessey Roncal, Norma E. Lee, Patricia J. Leed, Susan E. Rodriguez, Ana Mensa-Wilmot, Kojo Sciotti, Richard J. Pollastri, Michael P. TI Protozoan Parasite Growth Inhibitors Discovered by Cross-Screening Yield Potent Scaffolds for Lead Discovery SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID AFRICAN SLEEPING SICKNESS; AURORA KINASE INHIBITOR; DRUG DISCOVERY; TRYPANOSOMIASIS; COMPOUND; DISEASES AB Tropical protozoal infections are a significant cause of morbidity and mortality worldwide; four in particular (human African trypanosomiasis (HAT), Chagas disease, cutaneous leishmaniasis, and malaria) have an estimated combined burden of over 87 million disability-adjusted life years. New drugs are needed for each of these diseases, Building on the previous identification of NEU-617 (1) as a potent and nontoxic inhibitor of proliferation for the HAT pathogen (Trypanosoma brucei), we have now tested this class of analogs against other protozoal species: T. cruzi (Chagas disease), Leishmania major (cutaneous leishmaniasis), and Plasmodium falciparum (malaria). Based on hits identified in this screening campaign, we describe the preparation of several replacements for the quinazoline scaffold and report these inhibitors' biological activities against these parasites. In doing this, we have identified several potent proliferation inhibitors for each pathogen, such as 4-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-6-(4-((4-methyl-1,4-diazepan-1-yl)sulfonyl)phenyl)quinoline-3-carbonitrile (NEU-924, 83) for T. cruzi and N-(3-chloro-4-((3-fluorobenzypoxy)phenyl)-7-(4-((4-methyl-1,4-diazepan-1-yl)sulfonyl)phenyl)cinnolin-4-amine (NEU-1017, 68) for L. major and P. falciparum. C1 [Devine, William; Woodring, Jennifer L.; Swaminathan, Uma; Amata, Emanuele; Patel, Gautam; Pollastri, Michael P.] Northeastern Univ, Dept Chem & Chem Biol, Boston, MA 02115 USA. [Erath, Jessey; Rodriguez, Ana] NYU, Sch Med, Dept Microbiol, Div Parasitol, New York, NY 10010 USA. [Roncal, Norma E.; Lee, Patricia J.; Leed, Susan E.; Sciotti, Richard J.] Walter Reed Army Inst Res, Expt Therapeut, Silver Spring, MD 20910 USA. [Rodriguez, Ana] NYU, Sch Med, Antiinfect Screening Core, New York, NY 10010 USA. RP Pollastri, MP (reprint author), Northeastern Univ, Dept Chem & Chem Biol, 360 Huntington Ave, Boston, MA 02115 USA. EM m.pollastri@neu.edu OI amata, emanuele/0000-0002-4750-3479; Rodriguez, Ana/0000-0002-0060-3405 FU National Institutes of Health [R01AI082577, R56AI099476] FX This work was funded by the National Institutes of Health (Grant R01AI082577 to M.P.P.; Grant R56AI099476 to M.P.P. and K.M.-W.). A free academic license to OpenEye Scientific Software and ChemAxon for their suites of programs is gratefully acknowledged. We are grateful to AstraZeneca for performing the in vitro ADME experiments tabulated in Table 4. NR 34 TC 4 Z9 4 U1 5 U2 14 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0022-2623 EI 1520-4804 J9 J MED CHEM JI J. Med. Chem. PD JUL 23 PY 2015 VL 58 IS 14 BP 5522 EP 5537 DI 10.1021/acs.jmedchem.5b00515 PG 16 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA CN7OT UT WOS:000358624600012 PM 26087257 ER PT J AU Kundu, S Clavel, M Biswas, P Chen, B Song, HC Kumar, P Halder, NN Hudait, MK Banerji, P Sanghadasa, M Priya, S AF Kundu, Souvik Clavel, Michael Biswas, Pranab Chen, Bo Song, Hyun-Cheol Kumar, Prashant Halder, Nripendra N. Hudait, Mantu K. Banerji, Pallab Sanghadasa, Mohan Priya, Shashank TI Lead-free epitaxial ferroelectric material integration on semiconducting (100) Nb-doped SrTiO3 for low-power non-volatile memory and efficient ultraviolet ray detection SO SCIENTIFIC REPORTS LA English DT Article ID THIN-FILMS; POLARIZATION; DEVICES; DIODE AB We report lead-free ferroelectric based resistive switching non-volatile memory (NVM) devices with epitaxial (1-x)BaTiO3-xBiFeO(3) (x = 0.725) (BT-BFO) film integrated on semiconducting (100) Nb (0.7%) doped SrTiO3 (Nb: STO) substrates. The piezoelectric force microscopy (PFM) measurement at room temperature demonstrated ferroelectricity in the BT-BFO thin film. PFM results also reveal the repeatable polarization inversion by poling, manifesting its potential for read-write operation in NVM devices. The electroforming-free and ferroelectric polarization coupled electrical behaviour demonstrated excellent resistive switching with high retention time, cyclic endurance, and low set/reset voltages. X-ray photoelectron spectroscopy was utilized to determine the band alignment at the BT-BFO and Nb: STO heterojunction, and it exhibited staggered band alignment. This heterojunction is found to behave as an efficient ultraviolet photo-detector with low rise and fall time. The architecture also demonstrates half-wave rectification under low and high input signal frequencies, where the output distortion is minimal. The results provide avenue for an electrical switch that can regulate the pixels in low or high frequency images. Combined this work paves the pathway towards designing future generation low-power ferroelectric based microelectronic devices by merging both electrical and photovoltaic properties of BT-BFO materials. C1 [Kundu, Souvik; Chen, Bo; Song, Hyun-Cheol; Kumar, Prashant; Priya, Shashank] Virginia Tech, CEHMS, Dept Mech Engn, Blacksburg, VA 24061 USA. [Clavel, Michael; Hudait, Mantu K.] Virginia Tech, Bradley Dept Elect & Comp Engn, ADSEL, Blacksburg, VA 24061 USA. [Biswas, Pranab; Banerji, Pallab] Indian Inst Technol, Ctr Mat Sci, Kharagpur 721302, W Bengal, India. [Halder, Nripendra N.] Indian Inst Technol, Adv Technol Dev Ctr, Kharagpur 721302, W Bengal, India. [Sanghadasa, Mohan] US Army, AMRDEC, Huntsville, AL 35898 USA. RP Kundu, S (reprint author), Virginia Tech, CEHMS, Dept Mech Engn, Blacksburg, VA 24061 USA. EM souvikk@vt.edu; spriya@vt.edu OI Clavel, Michael/0000-0002-2925-6099 FU NSF [ECCS-1348653]; office of basic energy science, Department of Energy [DE-FG02-06ER46290] FX S.K, B.C, H.-C.S, and P.K acknowledge NSF INAMM program for financial support. S.K would like to thank ICTAS NCFL for providing characterization facilities. M.C acknowledges the final support from NSF ECCS-1348653. S.P acknowledges the partial support through office of basic energy science, Department of Energy (DE-FG02-06ER46290). S.K also acknowledges Dr. Zhou for providing PFM training and ferroelectric target preparations and G. Ghosh for some technical helps. NR 49 TC 7 Z9 7 U1 14 U2 76 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD JUL 23 PY 2015 VL 5 AR 12415 DI 10.1038/srep12415 PG 14 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CN3YB UT WOS:000358363400001 PM 26202946 ER PT J AU Heald, AE Charleston, JS Iversen, PL Warren, TK Saoud, JB Al-Ibrahim, M Wells, J Warfield, KL Swenson, DL Welch, LS Sazani, P Wong, M Berry, D Kaye, EM Bavari, S AF Heald, Alison E. Charleston, Jay S. Iversen, Patrick L. Warren, Travis K. Saoud, Jay B. Al-Ibrahim, Mohamed Wells, Jay Warfield, Kelly L. Swenson, Dana L. Welch, Lisa S. Sazani, Peter Wong, Michael Berry, Diane Kaye, Edward M. Bavari, Sina TI AVI-7288 for Marburg Virus in Nonhuman Primates and Humans SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID EBOLA-VIRUS; MORPHOLINO OLIGOMERS; FILOVIRUS INFECTIONS; HEMORRHAGIC-FEVER; EPIDEMIC; DISEASE AB BACKGROUND AVI-7288 is a phosphorodiamidate morpholino oligomer with positive charges that targets the viral messenger RNA that encodes Marburg virus (MARV) nucleoprotein. Its safety in humans is undetermined. METHODS We assessed the efficacy of AVI-7288 in a series of studies involving a lethal challenge with MARV in nonhuman primates. The safety of AVI-7288 was evaluated in a randomized, multiple-ascending-dose study in which 40 healthy humans (8 humans per dose group) received 14 once-daily infusions of AVI-7288 (1 mg, 4 mg, 8 mg, 12 mg, or 16 mg per kilogram of body weight) or placebo, in a 3: 1 ratio. We estimated the protective dose in humans by comparing pharmacokinetic variables in infected nonhuman primates, uninfected nonhuman primates, and uninfected humans. RESULTS Survival in infected nonhuman primates was dose-dependent, with survival rates of 0%, 30%, 59%, 87%, 100%, and 100% among monkeys treated with 0 mg, 3.75 mg, 7.5 mg, 15 mg, 20 mg, and 30 mg of AVI-7288 per kilogram, respectively (P < 0.001 with the use of the log-rank test for the comparison of survival across groups). No safety concern was identified at doses up to 16 mg per kilogram per day in humans. No serious adverse events were reported. Drug exposure (the area under the curve) was dose-dependent in both nonhuman primates and humans; drug clearance was independent of dose but was higher in nonhuman primates than in humans. The protective dose in humans was initially estimated, on the basis of exposure, to be 9.6 mg per kilogram per day (95% confidence interval, 6.6 to 12.5) for 14 days. Monte Carlo simulations supported a dose of 11 mg per kilogram per day to match the geometric mean protective exposure in nonhuman primates. CONCLUSIONS This study shows that, on the basis of efficacy in nonhuman primates and pharmacokinetic data in humans, AVI-7288 has potential as postexposure prophylaxis for MARV infection in humans. C1 [Heald, Alison E.; Charleston, Jay S.; Iversen, Patrick L.; Saoud, Jay B.; Sazani, Peter; Wong, Michael; Berry, Diane; Kaye, Edward M.] Sarepta Therapeut, Cambridge, MA USA. [Heald, Alison E.] Univ Washington, Div Infect Dis, Seattle, WA 98195 USA. [Iversen, Patrick L.] Oregon State Univ, Dept Environm & Mol Toxicol, Corvallis, OR 97331 USA. [Warren, Travis K.; Wells, Jay; Warfield, Kelly L.; Swenson, Dana L.; Welch, Lisa S.; Bavari, Sina] US Army Med Res Inst Infect Dis, Therapeut Discovery Ctr, Mol & Translat Sci, Frederick, MD USA. [Al-Ibrahim, Mohamed] SNBL Clin Pharmacol Ctr, Baltimore, MD USA. RP Heald, AE (reprint author), Harborview Med Ctr, 2 West Clin,Box 359930,325 Ninth Ave, Seattle, WA 98104 USA. EM healda@uw.edu FU Department of Defense FX Funded by the Department of Defense; ClinicalTrials.gov number, NCT01566877. NR 23 TC 10 Z9 10 U1 1 U2 2 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 EI 1533-4406 J9 NEW ENGL J MED JI N. Engl. J. Med. PD JUL 23 PY 2015 VL 373 IS 4 BP 339 EP 348 DI 10.1056/NEJMoa1410345 PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA CN3NL UT WOS:000358333500007 PM 26200980 ER PT J AU Potter, AW Gonzalez, JA Karis, AJ Xu, XJ AF Potter, Adam W. Gonzalez, Julio A. Karis, Anthony J. Xu, Xiaojiang TI Biophysical Assessment and Predicted Thermophysiologic Effects of Body Armor SO PLOS ONE LA English DT Article ID HEAT STRAIN; TEMPERATURE RESPONSE; EXERCISE; STRESS; PERFORMANCE; ENVIRONMENT; RESISTANCES; MECHANISMS; MANNEQUIN; HOT AB Introduction Military personnel are often required to wear ballistic protection in order to defend against enemies. However, this added protection increases mass carried and imposes additional thermal burden on the individual. Body armor (BA) is known to reduce combat casualties, but the effects of BA mass and insulation on the physical performance of soldiers are less well documented. Until recently, the emphasis has been increasing personal protection, with little consideration of the adverse impacts on human performance. Objective The purpose of this work was to use sweating thermal manikin and mathematical modeling techniques to quantify the tradeoff between increased BA protection, the accompanying mass, and thermal effects on human performance. Methods Using a sweating thermal manikin, total insulation (I-T, clo) and vapor permeability indexes (i(m)) were measured for a baseline clothing ensemble with and without one of seven increasingly protective U.S. Army BA configurations. Using mathematical modeling, predictions were made of thermal impact on humans wearing each configuration while working in hot/dry (desert), hot/humid (jungle), and temperate environmental conditions. Results In nearly still air (0.4 m/s), IT ranged from 1.57 to 1.63 clo and i(m) from 0.35 to 0.42 for the seven BA conditions, compared to IT and i(m) values of 1.37 clo and 0.45 respectively, for the baseline condition (no BA). Conclusion Biophysical assessments and predictive modeling show a quantifiable relationship exists among increased protection and increased thermal burden and decreased work capacity. This approach enables quantitative analysis of the tradeoffs between ballistic protection, thermal-work strain, and physical work performance. C1 [Potter, Adam W.; Gonzalez, Julio A.; Karis, Anthony J.; Xu, Xiaojiang] US Army, Environm Med Res Inst, Biophys & Biomed Modeling Div, Natick, MA 01760 USA. RP Potter, AW (reprint author), US Army, Environm Med Res Inst, Biophys & Biomed Modeling Div, Natick, MA 01760 USA. EM adam.w.potter.civ@mail.mil NR 33 TC 3 Z9 3 U1 1 U2 8 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUL 22 PY 2015 VL 10 IS 7 AR e0132698 DI 10.1371/journal.pone.0132698 PG 12 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CN7EO UT WOS:000358597100046 PM 26200906 ER PT J AU Bates, ME Larkin, S Keisler, JM Linkov, I AF Bates, Matthew E. Larkin, Sabrina Keisler, Jeffrey M. Linkov, Igor TI How decision analysis can further nanoinformatics SO BEILSTEIN JOURNAL OF NANOTECHNOLOGY LA English DT Editorial Material DE decision analysis; nanoinformatics; policy; portfolio analysis; risk assessment; value of information; weight of evidence ID NANOMATERIALS; WEIGHT AB The increase in nanomaterial research has resulted in increased nanomaterial data. The next challenge is to meaningfully integrate and interpret these data for better and more efficient decisions. Due to the complex nature of nanomaterials, rapid changes in technology, and disunified testing and data publishing strategies, information regarding material properties is often illusive, uncertain, and/or of varying quality, which limits the ability of researchers and regulatory agencies to process and use the data. The vision of nanoinformatics is to address this problem by identifying the information necessary to support specific decisions (a top-down approach) and collecting and visualizing these relevant data (a bottom-up approach). Current nanoinformatics efforts, however, have yet to efficiently focus data acquisition efforts on the research most relevant for bridging specific nanomaterial data gaps. Collecting unnecessary data and visualizing irrelevant information are expensive activities that overwhelm decision makers. We propose that the decision analytic techniques of multicriteria decision analysis (MCDA), value of information (VOI), weight of evidence (WOE), and portfolio decision analysis (PDA) can bridge the gap from current data collection and visualization efforts to present information relevant to specific decision needs. Decision analytic and Bayesian models could be a natural extension of mechanistic and statistical models for nanoinformatics practitioners to master in solving complex nanotechnology challenges. C1 [Bates, Matthew E.; Larkin, Sabrina; Linkov, Igor] US Army Engineer Res & Dev Ctr, Environm Lab, Concord, MA 02446 USA. [Keisler, Jeffrey M.] Univ Massachusetts, Coll Management, Dept Management Sci & Informat Syst, Boston, MA 02125 USA. RP Linkov, I (reprint author), US Army Engineer Res & Dev Ctr, Environm Lab, Concord, MA 02446 USA. EM Igor.Linkov@usace.army.mil NR 20 TC 1 Z9 1 U1 1 U2 6 PU BEILSTEIN-INSTITUT PI FRANKFURT AM MAIN PA TRAKEHNER STRASSE 7-9, FRANKFURT AM MAIN, 60487, GERMANY SN 2190-4286 J9 BEILSTEIN J NANOTECH JI Beilstein J. Nanotechnol. PD JUL 22 PY 2015 VL 6 BP 1594 EP 1600 DI 10.3762/bjnano.6.162 PG 7 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Science & Technology - Other Topics; Materials Science; Physics GA CN2UF UT WOS:000358276700001 PM 26425410 ER PT J AU Johnson, EA Guignet, MA Dao, TL Hamilton, TA Kan, RK AF Johnson, Erik A. Guignet, Michelle A. Dao, Thuy L. Hamilton, Tracey A. Kan, Robert K. TI Interleukin-18 expression increases in response to neurovascular damage following soman-induced status epilepticus in rats SO JOURNAL OF INFLAMMATION-LONDON LA English DT Article DE Interleukin 18; Status epilepticus; Soman (GD); Macrophage; T-cell; Neutrophil; Piriform cortex; Hippocampus; Thalamus ID SIGNAL-TRANSDUCTION PATHWAYS; INTERFERON-GAMMA PRODUCTION; TRAUMATIC BRAIN-INJURY; RHEUMATOID-ARTHRITIS; T-CELLS; MICROGLIAL ACTIVATION; MOLECULAR-MECHANISMS; INDUCED CONVULSIONS; INDUCED SEIZURES; B-CELLS AB Background: Status epilepticus (SE) can cause neuronal cell death and impaired behavioral function. Acute exposure to potent acetylcholinesterase inhibitors such as soman (GD) can cause prolonged SE activity, micro-hemorrhage and cell death in the hippocampus, thalamus and piriform cortex. Neuroinflammation is a prominent feature of brain injury with upregulation of multiple pro-inflammatory cytokines including those of the IL-1 family. The highly pleiotropic pro-inflammatory cytokine interleukin-18 (IL-18) belongs to the IL-1 family of cytokines and can propagate neuroinflammation by promoting immune cell infiltration, leukocyte and lymphocyte activation, and angiogenesis and helps facilitate the transition from the innate to the adaptive immune response. The purpose of this study is to characterize the regional and temporal expression of IL -18 and related factors in the brain following SE in a rat GD seizure model followed by localization of IL-18 to specific cell types. Methods: The protein levels of IL-18, vascular endothelial growth factor and interferon gamma was quantified in the lysates of injured brain regions up to 72 h following GD-induced SE onset using bead multiplex immunoassays. IL-18 was localized to various cell types using immunohistochemistry and transmission electron microscopy. In addition, macrophage appearance scoring and T-cell quantification was determined using immunohistochemistry. Micro-hemorrhages were identified using hematoxylin and eosin staining of brain sections. Results: Significant increases in IL-18 occurred in the piriform cortex, hippocampus and thalamus following SE. IL-18 was primarily expressed by endothelial cells and astrocytes associated with the damaged neurovascular unit. The increase in IL-18 was not related to macrophage accumulation, neutrophil infiltration or T-cell appearance in the injured tissue. Conclusions: These data show that IL-18 is significantly upregulated following GD-induced SE and localized primarily to endothelial cells in damaged brain vasculature. IL-18 upregulation occurred following leukocyte/lymphocyte infiltration and in the absence of other IL-18-related cytokines, suggesting another function, potentially for angiogenesis related to GD-induced micro-hemorrhage formation. Further studies at more chronic time points may help to elucidate this function. C1 [Johnson, Erik A.; Guignet, Michelle A.; Dao, Thuy L.; Kan, Robert K.] US Army, Med Res Inst Chem Def, Div Res, Pharmacol Branch, Aberdeen Proving Ground, MD 21010 USA. [Hamilton, Tracey A.] US Army, Med Res Inst Chem Def, Res Support Div, Comparat Pathol Branch, Aberdeen Proving Ground, MD 21010 USA. RP Johnson, EA (reprint author), US Army, Med Res Inst Chem Def, Div Res, Pharmacol Branch, Aberdeen Proving Ground, MD 21010 USA. EM erik.a.johnson1.civ@mail.mil FU Defense Threat Reduction Agency - Joint Science and Technology Office, Medical ST Division; U.S. Army's In-House Laboratory Independent Research (ILIR) program FX The authors would like to thank Nicole Rosellini, Marissa Babnew, and Dominique Scutella for their technical contributions to the research. This research was supported by the Defense Threat Reduction Agency - Joint Science and Technology Office, Medical S&T Division and by the U.S. Army's In-House Laboratory Independent Research (ILIR) program. The views expressed herein are those of the author(s) and do not reflect the official policy of the Department of Army, Department of Defense, or the U.S. Government. NR 54 TC 1 Z9 2 U1 0 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1476-9255 J9 J INFLAMM-LOND JI J. Inflamm.-Lond. PD JUL 22 PY 2015 VL 12 AR 43 DI 10.1186/s12950-015-0089-9 PG 11 WC Immunology SC Immunology GA CN1QR UT WOS:000358195400001 PM 26203299 ER PT J AU Carson, RA Sahni, O AF Carson, R. A. Sahni, O. TI Study of the relevant geometric parameters of the channel leak method for blast overpressure attenuation for a large caliber cannon SO COMPUTERS & FLUIDS LA English DT Article DE Blast; Overpressure; Shock; Pressure-ratio; Cannon; Leak-method ID SOUND PRESSURE; MUZZLE BLAST; FLOWFIELDS; FLOW AB This study examines the effect of relevant geometric parameters on blast overpressure attenuation and projectile exit velocity loss due to the channel leak method on a muzzle-loaded large caliber cannon. There are four basic geometric parameters which can be varied independently. These include the number of channels, channel length, channel height and channel width. From these basic parameters, three relevant parameters are selected which are expected to be most influential. These three relevant parameters include total leak volume, channel length, and total aspect ratio. Reduction in blast overpressure, and thus peak overpressure, is most affected by the leak volume, however, leak volume needs to be selected carefully to limit the loss in the projectile exit velocity. On the other hand, use of shorter channels is found to be detrimental for peak overpressure attenuation while a lower total aspect ratio has a positive effect. The best configuration, CLM-A1, shows over 50% reduction in peak overpressure at all monitored locations with about 4.8% loss in the projectile exit velocity which translates to the largest average Figure of Merit of 0.534. Shock structure and strength are also examined for the three best leak configurations, CLM-A1, CLM-E1 and CLM-E2, as well as the baseline configuration. Published by Elsevier Ltd. C1 [Carson, R. A.] US Army, ARDEC, Benet Labs, Watervliet, NY 12189 USA. [Sahni, O.] Rensselaer Polytech Inst, Mech Aerosp & Nucl Engn Dept, Troy, NY USA. RP Carson, RA (reprint author), US Army, ARDEC, Benet Labs, Watervliet, NY 12189 USA. EM roberta.carson26.civ@mail.mil FU U.S. Army Armament Research, Development and Engineering Center (ARDEC) Science Fellowship FX The authors would like to acknowledge several individuals for their contributions to this work. We would like to thank Andy Anderson, Willy Moss, and Sam Schofield from the Lawrence Livermore National Laboratory for their help in the development of the input deck for ALE3D and understanding the underlying discretization of the code. We would also like to thank Don Carlucci at Picatinny Arsenal and the support of U.S. Army Armament Research, Development and Engineering Center (ARDEC) Science Fellowship. The ARDEC Science Fellowship to the lead author was essential for this work. Additionally, we would like to thank Dr. Robert Dillon, Chief Scientist at Benet Laboratories, for his technical consultation in reviewing this work as well as Dan Crayon, Supervisor of the Armaments Health Monitoring and Mechatronics Branch at Benet Laboratories. NR 47 TC 2 Z9 2 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-7930 EI 1879-0747 J9 COMPUT FLUIDS JI Comput. Fluids PD JUL 22 PY 2015 VL 115 BP 211 EP 225 DI 10.1016/j.compfluid.2015.03.018 PG 15 WC Computer Science, Interdisciplinary Applications; Mechanics SC Computer Science; Mechanics GA CJ8SL UT WOS:000355773700017 ER PT J AU Liddell, AM Davey, RT Mehta, AK Varkey, JB Kraft, CS Tseggay, GK Badidi, O Faust, AC Brown, KV Suffredini, AF Barrett, K Wolcott, MJ Marconi, VC Lyon, GM Weinstein, GL Weinmeister, K Sutton, S Hazbun, M Albarino, CG Reed, Z Cannon, D Stroher, U Feldman, M Ribner, BS Lane, HC Fauci, AS Uyeki, TM AF Liddell, Allison M. Davey, Richard T., Jr. Mehta, Aneesh K. Varkey, Jay B. Kraft, Colleen S. Tseggay, Gebre K. Badidi, Oghenetega Faust, Andrew C. Brown, Katia V. Suffredini, Anthony F. Barrett, Kevin Wolcott, Mark J. Marconi, Vincent C. Lyon, G. Marshall, III Weinstein, Gary L. Weinmeister, Kenney Sutton, Shelby Hazbun, Munir Albarino, Cesar G. Reed, Zachary Cannon, Debi Stroeher, Ute Feldman, Mark Ribner, Bruce S. Lane, H. Clifford Fauci, Anthony S. Uyeki, Timothy M. TI Characteristics and Clinical Management of a Cluster of 3 Patients With Ebola Virus Disease, Including the First Domestically Acquired Cases in the United States SO ANNALS OF INTERNAL MEDICINE LA English DT Article ID WEST-AFRICA; SIERRA-LEONE AB Background: More than 26 000 cases of Ebola virus disease (EVD) have been reported in western Africa, with high mortality. Several patients have been medically evacuated to hospitals in the United States and Europe. Detailed clinical data are limited on the clinical course and management of patients with EVD outside western Africa. Objective: To describe the clinical characteristics and management of a cluster of patients with EVD, including the first cases of Ebola virus (EBOV) infection acquired in the United States. Design: Retrospective clinical case series. Setting: Three U.S. hospitals in September and October 2014. Patients: First imported EVD case identified in the United States and 2 secondary EVD cases acquired in the United States in critical care nurses who cared for the index case patient. Measurements: Clinical recovery, EBOV RNA level, resolution of Ebola viremia, survival with discharge from hospital, or death. Results: The index patient had high EBOV RNA levels, developed respiratory and renal failure requiring critical care support, and died. Both patients with secondary EBOV infection had nonspecific signs and symptoms and developed moderate illness; EBOV RNA levels were moderate, and both patients recovered. Limitation: Both surviving patients received uncontrolled treatment with multiple investigational agents, including convalescent plasma, which limits generalizability of the results. Conclusion: Early diagnosis, prompt initiation of supportive medical care, and moderate clinical illness likely contributed to successful outcomes in both survivors. The inability to determine the potential benefit of investigational therapies and the effect of patient-specific factors that may have contributed to less severe illness highlight the need for controlled clinical studies of these interventions, especially in the setting of a high level of supportive medical care. C1 [Liddell, Allison M.] Texas Hlth Presbyterian Hosp Dallas, Dallas, TX 75231 USA. NIH, Ctr Clin, Bethesda, MD 20892 USA. Emory Univ, Sch Med, Atlanta, GA USA. Ctr Dis Control & Prevent, Atlanta, GA USA. US Army, Med Res Inst Infect Dis, Frederick, MD USA. RP Liddell, AM (reprint author), Texas Hlth Presbyterian Hosp Dallas, 8230 Walnut Hill Lane,Suite 308, Dallas, TX 75231 USA. EM allisonliddell@texashealth.org RI Mehta, Aneesh/B-8054-2012; Marconi, Vincent/N-3210-2014 OI Mehta, Aneesh/0000-0002-6552-9162; Marconi, Vincent/0000-0001-8409-4689 FU National Center for Advancing Translational Sciences of the National Institutes of Health [Atlanta Clinical and Translational Science Institute] [UL1TR000454] FX The authors thank the entire staff of Texas Health Presbyterian Hospital Dallas, particularly Edward Goodman, MD, Beverly Dickson, MD, Otto Javier Marquez-Kerguelen, MD, Sarah S. Way, MD, Mark Till, MD, Glen Owen, MD, Bruce Wall, MD, Elaine Whitaker, MD, David Gonzales, MD, and Sarita Sharma-Louys, MD; Texas Health Resources for its unwavering support; William Dorman and Samantha Tostenson of the U.S. Army Medical Research Institute of Infectious Diseases for technical work on RT-PCR assays; David Henderson, MD, and Tara Palmore, MD, of the National Institutes of Health Clinical Center for their infection control leadership; the nursing and hospital epidemiology staff at the National Institutes of Health Clinical Center for their outstanding patient care; Anne Winkler, MD, of the Emory University Hospital Serious Communicable Diseases Unit for coordinating the convalescent plasma collection and administration; all of the members of the Emory University Hospital Serious Communicable Diseases Unit team for their outstanding contributions to the patient's excellent care (supported by award UL1TR000454 from the National Center for Advancing Translational Sciences of the National Institutes of Health [Atlanta Clinical and Translational Science Institute]); and Tara Sealy, MS, Aridith Gibbons, and Bobbie Rae Erickson, MPH, of the Centers for Disease Control and Prevention for their technical support on the laboratory assays. NR 19 TC 39 Z9 40 U1 2 U2 9 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 USA SN 0003-4819 EI 1539-3704 J9 ANN INTERN MED JI Ann. Intern. Med. PD JUL 21 PY 2015 VL 163 IS 2 BP 81 EP + DI 10.7326/M15-0530 PG 14 WC Medicine, General & Internal SC General & Internal Medicine GA CN4NS UT WOS:000358407500015 PM 25961438 ER PT J AU Scheff, JD Stallings, JD Reifman, J Rakesh, V AF Scheff, Jeremy D. Stallings, Jonathan D. Reifman, Jaques Rakesh, Vineet TI Mathematical Modeling of the Heat-Shock Response in HeLa Cells SO BIOPHYSICAL JOURNAL LA English DT Article ID PROTEIN-SYNTHESIS; TRANSCRIPTIONAL ACTIVATION; MOLECULAR CHAPERONES; GENE-TRANSCRIPTION; BINDING ACTIVITY; MAMMALIAN-CELLS; EXPRESSION; STRESS; HSP70; FACTOR-1 AB The heat-shock response is a key factor in diverse stress scenarios, ranging from hyperthermia to protein folding diseases. However, the complex dynamics of this physiological response have eluded mathematical modeling efforts. Although several computational models have attempted to characterize the heat-shock response, they were unable to model its dynamics across diverse experimental datasets. To address this limitation, we mined the literature to obtain a compendium of in vitro hyperthermia experiments investigating the heat-shock response in HeLa cells. We identified mechanisms previously discussed in the experimental literature, such as temperature-dependent transcription, translation, and heat-shock factor (HSF) oligomerization, as well as the role of heat-shock protein mRNA, and constructed an expanded mathematical model to explain the temperature-varying DNA-binding dynamics, the presence of free HSF during homeostasis and the initial phase of the heat-shock response, and heat-shock protein dynamics in the long-term heat-shock response. In addition, our model was able to consistently predict the extent of damage produced by different combinations of exposure temperatures and durations, which were validated against known cellular-response patterns. Our model was also in agreement with experiments showing that the number of HSF molecules in a HeLa cell is roughly 100 times greater than the number of stress-activated heat-shock element sites, further confirming the model's ability to reproduce experimental results not used in model calibration. Finally, a sensitivity analysis revealed that altering the homeostatic concentration of HSF can lead to large changes in the stress response without significantly impacting the homeostatic levels of other model components, making it an attractive target for intervention. Overall, this model represents a step forward in the quantitative understanding of the dynamics of the heat-shock response. C1 [Scheff, Jeremy D.; Reifman, Jaques; Rakesh, Vineet] US Army, High Performance Comp Software Applicat Inst, Telemed & Adv Technol Res Ctr, Med Res & Mat Command,Dept Def Biotechnol, Ft Detrick, MD 21702 USA. [Stallings, Jonathan D.] US Army, Ctr Environm Hlth Res, Environm Hlth Program, Ft Detrick, MD USA. RP Reifman, J (reprint author), US Army, High Performance Comp Software Applicat Inst, Telemed & Adv Technol Res Ctr, Med Res & Mat Command,Dept Def Biotechnol, Ft Detrick, MD 21702 USA. EM jaques.reifman.civ@mail.mil OI Stallings, Jonathan/0000-0002-6430-5888 FU U.S. Army Network Science Initiative; Military Operational Medicine Research Program, U.S. Army Medical Research and Materiel Command, Fort Detrick, MD FX The research was supported by the U.S. Army Network Science Initiative and the Military Operational Medicine Research Program, U.S. Army Medical Research and Materiel Command, Fort Detrick, MD. NR 46 TC 4 Z9 4 U1 0 U2 23 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 0006-3495 EI 1542-0086 J9 BIOPHYS J JI Biophys. J. PD JUL 21 PY 2015 VL 109 IS 2 BP 182 EP 193 DI 10.1016/j.bpj.2015.06.027 PG 12 WC Biophysics SC Biophysics GA CN3GE UT WOS:000358312800003 PM 26200855 ER PT J AU Chan, AP Sutton, G DePew, J Krishnakumar, R Choi, Y Huang, XZ Beck, E Harkins, DM Kim, M Lesho, EP Nikolich, MP Fouts, DE AF Chan, Agnes P. Sutton, Granger DePew, Jessica Krishnakumar, Radha Choi, Yongwook Huang, Xiao-Zhe Beck, Erin Harkins, Derek M. Kim, Maria Lesho, Emil P. Nikolich, Mikeljon P. Fouts, Derrick E. TI A novel method of consensus pan-chromosome assembly and large-scale comparative analysis reveal the highly flexible pan-genome of Acinetobacter baumannii SO GENOME BIOLOGY LA English DT Article ID ANTIBIOTIC-RESISTANCE GENES; EUROPEAN CLONE-II; MULTIDRUG-RESISTANCE; ESCHERICHIA-COLI; EFFLUX PUMPS; HAEMOPHILUS-INFLUENZAE; BACILLUS-SUBTILIS; BIOFILM FORMATION; ABIOTIC SURFACES; BETA-LACTAMASES AB Background: Infections by pan-drug resistant Acinetobacter baumannii plague military and civilian healthcare systems. Previous A. baumannii pan-genomic studies used modest sample sizes of low diversity and comparisons to a single reference genome, limiting our understanding of gene order and content. A consensus representation of multiple genomes will provide a better framework for comparison. A large-scale comparative study will identify genomic determinants associated with their diversity and adaptation as a successful pathogen. Results: We determine draft-level genomic sequence of 50 diverse military isolates and conduct the largest bacterial pan-genome analysis of 249 genomes. The pan-genome of A. baumannii is open when the input genomes are normalized for diversity with 1867 core proteins and a paralog-collapsed pan-genome size of 11,694 proteins. We developed a novel graph-based algorithm and use it to assemble the first consensus pan-chromosome, identifying both the order and orientation of core genes and flexible genomic regions. Comparative genome analyses demonstrate the existence of novel resistance islands and isolates with increased numbers of resistance island insertions over time, from single insertions in the 1950s to triple insertions in 2011. Gene clusters responsible for carbon utilization, siderophore production, and pilus assembly demonstrate frequent gain or loss among isolates. Conclusions: The highly variable and dynamic nature of the A. baumannii genome may be the result of its success in rapidly adapting to both abiotic and biotic environments through the gain and loss of gene clusters controlling fitness. Importantly, some archaic adaptation mechanisms appear to have reemerged among recent isolates. C1 [Chan, Agnes P.; Sutton, Granger; DePew, Jessica; Krishnakumar, Radha; Choi, Yongwook; Beck, Erin; Harkins, Derek M.; Kim, Maria; Fouts, Derrick E.] J Craig Venter Inst, Rockville, MD 20850 USA. [Huang, Xiao-Zhe; Nikolich, Mikeljon P.] Walter Reed Army Inst Res, Bacterial Dis Branch, Dept Emerging Bacterial Infect, Silver Spring, MD USA. [Lesho, Emil P.] Walter Reed Army Inst Res, Bacterial Dis Branch, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD USA. RP Fouts, DE (reprint author), J Craig Venter Inst, Rockville, MD 20850 USA. EM dfouts@jcvi.org FU federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services [HHSN272200900007C]; federal funds from the Department of Defense, Defense Medical Research and Development Program - Military Infectious Diseases Basic Research Award [W81XWH-12-2-0106] FX The authors thank Mary Kim, Diana Radune and Jaya Onuska for performing genome closure finishing reactions on the IHQD genomes, Galina Koroleva for 16S rRNA sequencing for validation of the 43 non-MRSN isolates, Ravi Sanka for modifications to the JCVI in-house MLST pipeline, and Drs M. Wright and M. Adams for helpful suggestions and comments. The opinions and assertions herein are solely those of the authors and are not to be construed as official or representing those of the US Army or Department of Defense. This project was funded in part with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services under contract number HHSN272200900007C and from the Department of Defense, Defense Medical Research and Development Program - Military Infectious Diseases Basic Research Award number W81XWH-12-2-0106. NR 116 TC 11 Z9 11 U1 1 U2 6 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1465-6906 EI 1474-760X J9 GENOME BIOL JI Genome Biol. PD JUL 21 PY 2015 VL 16 AR 143 DI 10.1186/s13059-015-0701-6 PG 28 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA CN0QE UT WOS:000358117600001 PM 26195261 ER PT J AU Cardile, AP Tan, C Lustik, MB Stratton, AN Madar, CS Elegino, J Hsue, G AF Cardile, Anthony P. Tan, Christopher Lustik, Michael B. Stratton, Amy N. Madar, Cristian S. Elegino, Jun Hsue, Guenther TI Optimization of time to initial vancomycin target trough improves clinical outcomes SO SPRINGERPLUS LA English DT Article DE Vancomycin; MRSA; TDM; Trough ID RESISTANT STAPHYLOCOCCUS-AUREUS; CRITICALLY-ILL PATIENTS; MINIMUM INHIBITORY CONCENTRATION; ACUTE KIDNEY INJURY; ORDER-ENTRY SYSTEM; CARE-UNIT PATIENTS; INTENSIVE-CARE; CONSENSUS GUIDELINES; HOSPITALIZED-PATIENTS; DOSING ASSESSMENT AB Background: Outcomes data for the efficacy of interventions designed to decrease the time to initial target vancomycin troughs are sparse. Objective: A vancomycin therapeutic drug monitoring (TDM) program was initiated to reduce the time to initial target troughs and to examine the impact on clinical outcomes. Methods: Single-center, pre- and post-intervention observational study in a 250 bed teaching facility. Adult inpatients treated with physician-guided, vancomycin therapy (historical control, CTRL) were compared to high trough, pharmacist-guided vancomycin therapy (TDM). Nephrotoxicity analyses were conducted to the ensure safety of the TDM. Clinical outcome analysis was limited to patients with normal renal function and culture-confirmed gram positive infections and a pre-defined MRSA subset. Results: 340 patients met initial inclusion criteria for the nephrotoxicity analysis (TDM, n = 173; CTRL, n = 167). Acute kidney injury occurrence was similar between the CTRL (n = 20) and TDM (n = 23) groups (p = 0.7). Further exclusions yielded 145 patients with gram positive infections for clinical outcomes evaluation (TDM, n = 66; CTRL, n = 75). The time to initial target trough was shorter in the TDM group (3 vs. 5 days, p < 0.001). Patients in the TDM group discharged from the hospital more rapidly, 7 vs. 14 days (Hazards Ratio (HR), 1.41; 95% Confidence Interval [CI] 1.08-1.83; p = 0.01), reached clinical stability faster, 4 vs. 8 days (HR, 1.51; 95% CI 1.08-2.11; p = 0.02), and had shorter courses of vancomycin, 4 vs. 7 days (HR, 1.5; 95% CI 1.15-1.95; p = 0.003). In the MRSA infection subset (TDM, n = 36; CTRL, n = 35), patients in the TDM group discharged from the hospital more rapidly, 7 vs. 16 days (HR, 1.89; 95% CI 1.08-3.3; p = 0.03), reached clinical stability faster, 4 vs. 6 days (HR, 2.69; 95% CI 1.27-5.7; p = 0.01), and had shorter courses of vancomycin, 5 vs. 8 days (HR, 2.52; 95% CI 1.38-4.6; p = 0.003). Attaining initial target troughs in < 5 days versus = 5 days was associated with improved clinical outcomes. All cause in-hospital mortality, and vancomycin treatment failure occurred at comparable rates between groups. Conclusions: Interventions designed to decrease the time to reach initial target vancomycin troughs can improve clinical outcomes in gram positive infections, and in particular MRSA infections. C1 [Cardile, Anthony P.; Stratton, Amy N.; Madar, Cristian S.; Elegino, Jun; Hsue, Guenther] Tripler Army Med Ctr, Dept Med, Honolulu, HI 96859 USA. [Tan, Christopher] Tripler Army Med Ctr, Dept Pharm, Honolulu, HI 96859 USA. [Lustik, Michael B.] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. [Hsue, Guenther] Tripler Army Med Ctr, Dept Infect Dis, Honolulu, HI 96859 USA. RP Cardile, AP (reprint author), Tripler Army Med Ctr, Dept Med, 1 Jarrett White Roadm, Honolulu, HI 96859 USA. EM anthony.p.cardile.mil@mail.mil NR 55 TC 4 Z9 4 U1 3 U2 8 PU SPRINGER INTERNATIONAL PUBLISHING AG PI CHAM PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND SN 2193-1801 J9 SPRINGERPLUS JI SpringerPlus PD JUL 19 PY 2015 VL 4 AR 364 DI 10.1186/s40064-015-1146-9 PG 14 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CO7XC UT WOS:000359375800001 PM 26203410 ER PT J AU Rolland, M Modjarrad, K AF Rolland, Morgane Modjarrad, Kayvon TI Multiple co-circulating HIV-1 subtypes in the Middle East and North Africa SO AIDS LA English DT Article ID PHYLOGENIES AB HIV-1 incidence has been increasing more rapidly in the Middle East and North Africa than in any other global region. Despite this trend, HIV epidemiology in the region remains poorly defined. We conducted an analysis of 3284 publicly available HIV-1 sequences from 15 countries in the Middle East and North Africa to better characterize the regional epidemic. A phylogenetic tree based on the reverse transcriptase gene revealed a complex mosaic of diverse HIV subtypes and circulating recombinant forms across the region. C1 [Rolland, Morgane; Modjarrad, Kayvon] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. [Rolland, Morgane; Modjarrad, Kayvon] Henry M Jackson Fdn Adv Mil Med Inc, Bethesda, MD USA. RP Rolland, M (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Bldg 503,Room 2A38, Silver Spring, MD 20910 USA. EM mrolland@hivresearch.org FU National Institute of Allergy and Infectious Diseases [Y1-AI-2642-12]; US Army Medical Research and Material Command [Y1-AI-2642-12]; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; US Department of Defense [W81XWH-07-2-0067] FX The study was supported by an Interagency Agreement between the National Institute of Allergy and Infectious Diseases and the US Army Medical Research and Material Command (Y1-AI-2642-12) and by a cooperative agreement between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the US Department of Defense (W81XWH-07-2-0067). NR 10 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0269-9370 EI 1473-5571 J9 AIDS JI Aids PD JUL 17 PY 2015 VL 29 IS 11 BP 1417 EP 1419 DI 10.1097/QAD.0000000000000764 PG 3 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA CR1VK UT WOS:000361113100002 PM 26091303 ER PT J AU Wang, WY Shang, SL Wang, Y Hu, YJ Darling, KA Kecskes, LJ Mathaudhu, SN Hui, XD Liu, ZK AF Wang, William Yi Shang, Shun Li Wang, Yi Hu, Yong Jie Darling, Kristopher A. Kecskes, Laszlo J. Mathaudhu, Suveen N. Hui, Xi Dong Liu, Zi-Kui TI Lattice distortion induced anomalous ferromagnetism and electronic structure in FCC Fe and Fe-TM (TM = Cr, Ni, Ta and Zr) alloys SO MATERIALS CHEMISTRY AND PHYSICS LA English DT Article DE Magnetic materials; Ab initio calculation; Electronic structure; Defects; Crystal structure ID BINARY NANOCRYSTALLINE ALLOYS; TOTAL-ENERGY CALCULATIONS; STACKING-FAULT ENERGIES; WAVE BASIS-SET; GRAIN-BOUNDARY; METALS; 1ST-PRINCIPLES; IRON; STABILITY; DENSITY AB Magnetic properties of BCC, FCC and HCP Fe and the effects of the Sigma 3 < 0<(1)over bar>0 > {111} grain boundary (GB) and the alloying elements of Cr, Ni, Ta and Zr are investigated by first-principles calculations. The FCC Fe changes continuously from the non-magnetic state at low volumes to the ferromagnetic state at high volumes. It is observed that Sigma 3{111} type GBs in FCC Fe have a negative formation energy since the formation of Sigma 3 GB is attributed to the local FCC-HCP transformation. Moreover, consistent with the variation of equilibrium volume caused by TM solute atoms, the magnetic moment of FCC Fe70TM2 is decreased with alloying Ni while increased with alloying Cr, Ta and Zr. Due to the difference in the valence electrons and atomic radius among those solute atoms, the chemical and mechanical effects on the bond structure of Sigma 3{111} GB in Fe and Fe70TM2 are respectively characterized by deformation electron density and plots of spin alignments. It is understood that the variation of the spin state of Fe70TM20 is dominated by the electron redistributions, as illustrated by the spin-flipping and the change of the bond structure. This work provides an insight into the effect of lattice distortion on ferromagnetism of FCC Fe and Fe70TM2 (C) 2015 Elsevier B.V. All rights reserved. C1 [Wang, William Yi; Shang, Shun Li; Wang, Yi; Hu, Yong Jie; Liu, Zi-Kui] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. [Darling, Kristopher A.; Kecskes, Laszlo J.] US Army Res Lab, Weap & Mat Res Directorate, RDRL WMM B, Aberdeen Proving Ground, MD 21005 USA. [Mathaudhu, Suveen N.] Univ Calif Riverside, Dept Mech Engn, Riverside, CA 92505 USA. [Wang, William Yi; Hui, Xi Dong] Univ Sci & Technol Beijing, State Key Lab Adv Met & Mat, Beijing 100083, Peoples R China. RP Wang, WY (reprint author), Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. EM yuw129@psu.edu RI Wang, William Yi/F-8212-2011; Wang, Yi/D-1032-2013; Shang, Shun-Li/A-6564-2009; Liu, Zi-Kui/A-8196-2009 OI Wang, William Yi/0000-0002-8814-525X; Shang, Shun-Li/0000-0002-6524-8897; Liu, Zi-Kui/0000-0003-3346-3696 FU National Science Foundation [DMR-1006557]; Army Research Laboratory in the Unites States [W911NF-08-2-0084]; National Natural Science Foundation of China [50431030, 50871013]; American Academic Exchange Service; China Scholarship Council [2008[3072]]; NSF [OCI-0821527, ACI-1053575] FX This work was financially supported by the National Science Foundation (Grant No. DMR-1006557) and the Army Research Laboratory (W911NF-08-2-0084) in the Unites States and National Natural Science Foundation of China (50431030 and 50871013). W.Y. Wang acknowledges the support from the Project Based Personnel Exchange Program with American Academic Exchange Service and China Scholarship Council (2008[3072]). First-principles calculations were carried out on the LION clusters at the Pennsylvania State University supported by the Materials Simulation Center and the Research Computing and Cyberinfrastructure unit at the Pennsylvania State University. Calculations were also carried out on the CyberStar funded by NSF through grant OCI-0821527 and the XSEDE supported by NSF with Grant No. ACI-1053575. NR 53 TC 2 Z9 2 U1 10 U2 28 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0254-0584 EI 1879-3312 J9 MATER CHEM PHYS JI Mater. Chem. Phys. PD JUL 15 PY 2015 VL 162 BP 748 EP 756 DI 10.1016/j.matchemphys.2015.06.051 PG 9 WC Materials Science, Multidisciplinary SC Materials Science GA CP5XN UT WOS:000359958800094 ER PT J AU Zhao, XG Fan, KB Zhang, JD Seren, HR Metcalfe, GD Wraback, M Averitt, RD Zhang, X AF Zhao, Xiaoguang Fan, Kebin Zhang, Jingdi Seren, Huseyin R. Metcalfe, Grace D. Wraback, Michael Averitt, Richard D. Zhang, Xin TI Optically tunable metamaterial perfect absorber on highly flexible substrate SO SENSORS AND ACTUATORS A-PHYSICAL LA English DT Article; Proceedings Paper CT 27th IEEE International Conference on Micro Electro Mechanical Systems (MEMS) CY JAN 26-30, 2014 CL San Francisco, CA SP IEEE, Robot & Automat Soc DE Metamaterials perfect absorber; Optically tuning; Flexible; Terahertz ID MODULATOR AB We present our recent progress on a highly flexible tunable perfect absorber at terahertz frequencies. Metamaterial unit cells were patterned on thin GaAs patches, which were fashioned in an array on a 10 mu m thick polyimide substrate via semiconductor transfer technique, and the backside of the substrate was coated with gold film as a ground plane. Optical-pump THz-probe reflection measurements show that the absorptivity can be tuned up to 25% at 0.78 THz and 40% at 1.75 THz through photo-excitation of free carriers in GaAs layers in presence of 800 am pump beam. Our flexible tunable metamaterial perfect absorber has potential applications in energy harvesting, THz modulation and even camouflages coating. (C) 2015 Elsevier B.V. All rights reserved. C1 [Zhao, Xiaoguang; Fan, Kebin; Seren, Huseyin R.; Zhang, Xin] Boston Univ, Dept Mech Engn, Boston, MA 02215 USA. [Zhang, Jingdi; Averitt, Richard D.] Boston Univ, Dept Phys, Boston, MA 02215 USA. [Metcalfe, Grace D.; Wraback, Michael] US Army Res Lab, Adelphi, MD 20783 USA. [Averitt, Richard D.] Univ Calif San Diego, Dept Phys, La Jolla, CA 92093 USA. RP Zhang, X (reprint author), Boston Univ, Dept Mech Engn, 110 Cummington Mall, Boston, MA 02215 USA. EM xinz@bu.edu RI Zhang, Xin/B-9244-2009; Fan, Kebin/B-2984-2012 OI Zhang, Xin/0000-0002-4413-5084; Fan, Kebin/0000-0002-0275-0871 NR 18 TC 6 Z9 7 U1 5 U2 25 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0924-4247 J9 SENSOR ACTUAT A-PHYS JI Sens. Actuator A-Phys. PD JUL 15 PY 2015 VL 231 BP 74 EP 80 DI 10.1016/j.sna.2015.02.040 PG 7 WC Engineering, Electrical & Electronic; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA CP4WK UT WOS:000359883100011 ER PT J AU Jones, CL Clancy, M Honnold, C Singh, S Snesrud, E Onmus-Leone, F McGann, P Ong, AC Kwak, Y Waterman, P Zurawski, DV Clifford, RJ Lesho, E AF Jones, Crystal L. Clancy, Megan Honnold, Cary Singh, Shweta Snesrud, Erik Onmus-Leone, Fatma McGann, Patrick Ong, Ana C. Kwak, Yoon Waterman, Paige Zurawski, Daniel V. Clifford, Robert J. Lesho, Emil TI Fatal Outbreak of an Emerging Clone of Extensively Drug-Resistant Acinetobacter baumannii With Enhanced Virulence SO CLINICAL INFECTIOUS DISEASES LA English DT Article DE Acinetobacter baumannii; virulence; outbreak; extensively drug resistant ID CRITICALLY-ILL PATIENTS; ACUTE PHYSIOLOGY; MATCHED COHORT; MOUSE MODEL; BACTEREMIA; MORTALITY; PNEUMONIA; INFECTION; SCORE; INTERVENTION AB Background. Severe Acinetobacter baumannii infections in immunocompetent patients are uncommon, and the virulence mechanisms of this organism are not fully understood. Methods. Following an outbreak of fatal A. baumannii infections in a cohort of relatively immunocompetent patients (low comorbidity and illness severity scores), isolates were investigated with comparative genomics and in animal models. Results. Two unrelated A. baumannii clades were associated with the outbreak. The clone associated with the majority of patient deaths, clade B, is evolutionarily distinct from the 3 international clonal complexes, belongs to multilocus sequence type (MLST) 10, and is most closely related to strains isolated from the Czech Republic, California, and Germany in 1994, 1997, and 2003, respectively. In 2 different murine models, clade B isolates were more virulent than comparator strains, including the highly virulent reference strain AB5075. The most virulent clade B derivative, MRSN 16897, was isolated from the patient with the lowest combined comorbidity/illness severity score. Clade B isolates possess a unique combination of putative virulence genes involved in iron metabolism, protein secretion, and glycosylation, which was leveraged to develop a rapid and specific clinical assay to detect this clade that cannot be distinguished by MLST. Conclusions. Clade B warrants continued surveillance and investigation. C1 [Jones, Crystal L.; Singh, Shweta; Zurawski, Daniel V.] Walter Reed Army Inst Res, Dept Wound Infect, Silver Spring, MD USA. [Clancy, Megan] Providence Alaska Med Ctr, Anchorage, AK USA. [Honnold, Cary] Walter Reed Army Inst Res, Dept Pathol, Silver Spring, MD USA. [Snesrud, Erik; Onmus-Leone, Fatma; McGann, Patrick; Ong, Ana C.; Kwak, Yoon; Waterman, Paige; Clifford, Robert J.; Lesho, Emil] Walter Reed Army Inst Res, Multidrug Resistant Organism Resp & Surveillance, Silver Spring, MD USA. RP Jones, CL (reprint author), 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM crystal.l.jones120.ctr@mail.mil OI Zurawski, Daniel/0000-0002-7920-5601 FU Defense Medical Research and Development Program [D61_I_10_J2_160]; Armed Forces Health Surveillance Center's Global Emerging Infections Surveillance and Response System; Military Infectious Diseases Research Program; Defense Medical Research and Development Program; US Army Medical Command FX This work was supported by the Defense Medical Research and Development Program (D61_I_10_J2_160). Surveillance and genomics were supported by the Armed Forces Health Surveillance Center's Global Emerging Infections Surveillance and Response System, and the US Army Medical Command. C. L. J., S. S., and D. V. Z. are funded via multiple grants from the Military Infectious Diseases Research Program and the Defense Medical Research and Development Program. NR 40 TC 12 Z9 12 U1 2 U2 10 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD JUL 15 PY 2015 VL 61 IS 2 BP 145 EP 154 DI 10.1093/cid/civ225 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA CO7MD UT WOS:000359342500002 PM 25824815 ER PT J AU Carlisle, RT Digiovanni, J AF Carlisle, Robert Thomas Digiovanni, John TI Differential Diagnosis of the Swollen Red Eyelid SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID HERPES-ZOSTER OPHTHALMICUS; ORBITAL CELLULITIS; PERIORBITAL INFECTIONS; CAPILLARY HEMANGIOMA; CLINICAL-FEATURES; NECK INFECTIONS; MANAGEMENT; CHALAZION; SINUSITIS; HEAD AB The swollen red eyelid is a common presentation in primary care. An understanding of the anatomy of the orbital region can guide care. Factors that guide diagnosis and urgency of care include acute vs. subacute onset of symptoms, presence or absence of pain, identifiable mass within the eyelid vs. diffuse lid swelling, and identification of vision change or ophthalmoplegia. Superficial skin processes presenting with swollen red eyelid include vesicles of herpes zoster ophthalmicus; erythematous irritation of contact dermatitis; raised, dry plaques of atopic dermatitis; and skin changes of malignancies, such as basal or squamous cell carcinoma. A well-defined mass at the lid margin is often a hordeolum or stye. A mass within the midportion of the lid is commonly a chalazion. Preseptal and orbital cellulitis are important to identify, treat, and differentiate from each other. Orbital cellulitis is more often marked by changes in ability of extraocular movements and vision as opposed to preseptal cellulitis where these characteristics are classically normal. Less commonly, autoimmune processes of the orbit or ocular tumors with mass effect can create an initial impression of a swollen eyelid. (Copyright (C) 2015 American Academy of Family Physicians.) C1 [Carlisle, Robert Thomas; Digiovanni, John] Tripler Army Med Ctr, Dept Family Med, Honolulu, HI 96858 USA. RP Carlisle, RT (reprint author), Tripler Army Med Ctr, Dept Family Med, 1 Jarrett White Rd, Honolulu, HI 96858 USA. EM Robert.t.carlisle8civ@mail.mil NR 39 TC 0 Z9 0 U1 4 U2 8 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X EI 1532-0650 J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD JUL 15 PY 2015 VL 92 IS 2 BP 106 EP 112 PG 7 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA CN4KN UT WOS:000358399100003 PM 26176369 ER PT J AU Prentice, HA Tomaras, GD Geraghty, DE Apps, R Fong, YY Ehrenberg, PK Rolland, M Kijak, GH Krebs, SJ Nelson, W DeCamp, A Shen, XY Yates, NL Zolla-Pazner, S Nitayaphan, S Rerks-Ngarm, S Kaewkungwal, J Pitisuttithum, P Ferrari, G McElrath, MJ Montefiori, DC Bailer, RT Koup, RA O'Connell, RJ Robb, ML Michael, NL Gilbert, PB Kim, JH Thomas, R AF Prentice, Heather A. Tomaras, Georgia D. Geraghty, Daniel E. Apps, Richard Fong, Youyi Ehrenberg, Philip K. Rolland, Morgane Kijak, Gustavo H. Krebs, Shelly J. Nelson, Wyatt DeCamp, Allan Shen, Xiaoying Yates, Nicole L. Zolla-Pazner, Susan Nitayaphan, Sorachai Rerks-Ngarm, Supachai Kaewkungwal, Jaranit Pitisuttithum, Punnee Ferrari, Guido McElrath, M. Juliana Montefiori, David C. Bailer, Robert T. Koup, Richard A. O'Connell, Robert J. Robb, Merlin L. Michael, Nelson L. Gilbert, Peter B. Kim, Jerome H. Thomas, Rasmi TI HLA class II genes modulate vaccine-induced antibody responses to affect HIV-1 acquisition SO SCIENCE TRANSLATIONAL MEDICINE LA English DT Article ID T-CELL RESPONSES; EFFICACY TRIAL; POTENT NEUTRALIZATION; ENVELOPE GLYCOPROTEIN; ALVAC-HIV; GP120; ASSOCIATION; ANTIGEN; BINDING; SUSCEPTIBILITY AB In the RV144 vaccine trial, two antibody responses were found to correlate with HIV-1 acquisition. Because human leukocyte antigen (HLA) class II-restricted CD4(+) T cells are involved in antibody production, we tested whether HLA class II genotypes affected HIV-1-specific antibody levels and HIV-1 acquisition in 760 individuals. Indeed, antibody responses correlated with acquisition only in the presence of single host HLA alleles. Envelope (Env)-specific immunoglobulin A (IgA) antibodies were associated with increased risk of acquisition specifically in individuals with DQB1*06. IgG antibody responses to Env amino acid positions 120 to 204 were higher and were associated with decreased risk of acquisition and increased vaccine efficacy only in the presence of DPB1*13. Screening IgG responses to overlapping peptides spanning Env 120-204 and viral sequence analysis of infected individuals defined differences in vaccine response that were associated with the presence of DPB1*13 and could be responsible for the protection observed. Overall, the underlying genetic findings indicate that HLA class II modulated the quantity, quality, and efficacy of antibody responses in the RV144 trial. C1 [Prentice, Heather A.; Ehrenberg, Philip K.; Rolland, Morgane; Kijak, Gustavo H.; Krebs, Shelly J.; Robb, Merlin L.; Michael, Nelson L.; Kim, Jerome H.; Thomas, Rasmi] US Mil HIV Res Program, Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Prentice, Heather A.; Rolland, Morgane; Kijak, Gustavo H.; Krebs, Shelly J.; Robb, Merlin L.; Thomas, Rasmi] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD 20818 USA. [Tomaras, Georgia D.; Shen, Xiaoying; Yates, Nicole L.; Ferrari, Guido; Montefiori, David C.] Duke Univ, Sch Med, Duke Human Vaccine Inst, Durham, NC 27710 USA. [Geraghty, Daniel E.; Nelson, Wyatt] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98109 USA. [Apps, Richard] Leidos Biomed Res Inc, Frederick Natl Lab Canc Res, Frederick, MD 21702 USA. [Fong, Youyi; DeCamp, Allan; McElrath, M. Juliana; Gilbert, Peter B.] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98109 USA. [Zolla-Pazner, Susan] NYU, Sch Med, Vet Affairs New York Harbor Healthcare Syst, New York, NY 10016 USA. [Zolla-Pazner, Susan] NYU, Sch Med, Dept Pathol, New York, NY 10016 USA. [Nitayaphan, Sorachai; O'Connell, Robert J.] Armed Forces Res Inst Med Sci, US Army Med Component, Dept Retrovirol, Bangkok 10400, Thailand. [Rerks-Ngarm, Supachai] Minist Publ Hlth, Dept Dis Control, Nonthaburi 11000, Thailand. [Kaewkungwal, Jaranit] Mahidol Univ, Fac Trop Med, Ctr Excellence Biomed & Publ Hlth Informat BIOPHI, Bangkok 10400, Thailand. [Pitisuttithum, Punnee] Mahidol Univ, Fac Trop Med, Vaccine Trial Ctr, Bangkok 10400, Thailand. [Bailer, Robert T.; Koup, Richard A.] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA. RP Thomas, R (reprint author), US Mil HIV Res Program, Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. EM rthomas@hivresearch.org RI Tomaras, Georgia/J-5041-2016 FU Henry M. Jackson Foundation for the Advancement of Military Medicine Inc. [W81XWH-07-2-0067]; U.S. Department of Defense, Bill & Melinda Gates Foundation (Collaboration for AIDS Vaccine Discovery) [W81XWH-07-2-0067, OPP1032144]; NIH/NIAID [UM1 AI068618, AI064518]; U.S. National Institute of Allergy and Infectious Disease FX This work was supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine Inc. and the U.S. Department of Defense, Bill & Melinda Gates Foundation (Collaboration for AIDS Vaccine Discovery, grant OPP1032144), and the NIH/NIAID (UM1 AI068618 and Duke Center for AIDS Research AI064518). This research was funded, in part, by the U.S. National Institute of Allergy and Infectious Disease. NR 43 TC 7 Z9 7 U1 0 U2 7 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 1946-6234 EI 1946-6242 J9 SCI TRANSL MED JI Sci. Transl. Med. PD JUL 15 PY 2015 VL 7 IS 296 AR 296ra112 DI 10.1126/scitranslmed.aab4005 PG 8 WC Cell Biology; Medicine, Research & Experimental SC Cell Biology; Research & Experimental Medicine GA CN9AQ UT WOS:000358738400005 PM 26180102 ER PT J AU Kenefick, RW Heavens, KR Dennis, WE Caruso, EM Guerriere, KI Charkoudian, N Cheuvront, SN AF Kenefick, Robert W. Heavens, K. R. Dennis, W. E. Caruso, E. M. Guerriere, K. I. Charkoudian, N. Cheuvront, S. N. TI Quantification of chromatographic effects of vitamin B supplementation in urine and implications for hydration assessment SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE hydration assessment; urine color; vitamin supplementation ID RIBOFLAVIN; EXERCISE; B12 AB Changes in body water elicit reflex adjustments at the kidney, thus maintaining fluid volume homeostasis. These renal adjustments change the concentration and color of urine, variables that can, in turn, be used as biomarkers of hydration status. It has been suggested that vitamin supplementation alters urine color; it is unclear whether any such alteration would confound hydration assessment via colorimetric evaluation. We tested the hypothesis that overnight vitamin B-2 and/or B-12 supplementation alters urine color as a marker of hydration status. Thirty healthy volunteers were monitored during a 3-day euhydrated baseline, confirmed via first morning nude body mass, urine specific gravity, and urine osmolality. Volunteers then randomly received B-2 (n = 10), B-12 (n = 10), or B-2 + B-12 (n = 10) at similar to 200 x recommended dietary allowance. Euhydration was verified on trial days (two of the following: body mass +/- 1.0% of the mean of visits 1-3, urine specific gravity < 1.02, urine osmolality < 700 mmol/kg). Vitamin purity and urinary B-2 concentration ([B-2]) and [B-12] were quantified via ultraperformance liquid chromatography. Two independent observers assessed urine color using an eight-point standardized color chart. Following supplementation, urinary [B-2] was elevated; however, urine color was not different between nonsupplemented and supplemented trials. For example, in the B-2 trial, urinary [B-2] increased from 8.6 x 10(4) +/- 7.7 x 10(4) to 5.7 x 10(6) +/- 5.3 x 10(6) nmol/l (P < 0.05), and urine color went from 4 +/- 1 to 5 +/- 1 (P > 0.05). Both conditions met the euhydrated color classification. We conclude that a large overnight dose of vitamins B-2 and B-12 does not confound assessment of euhydrated status via urine color. C1 [Kenefick, Robert W.; Heavens, K. R.; Caruso, E. M.; Guerriere, K. I.; Charkoudian, N.; Cheuvront, S. N.] US Army, Environm Med Res Inst, Natick, MA 01760 USA. [Dennis, W. E.] US Army, Ctr Environm Hlth Res, Ft Detrick, MD USA. RP Kenefick, RW (reprint author), US Army, Environm Med Res Inst, Thermal & Mt Med Div, Kansas St, Natick, MA 01760 USA. EM Robert.W.Kenefick.civ@mail.mil NR 20 TC 2 Z9 2 U1 1 U2 5 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 EI 1522-1601 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD JUL 15 PY 2015 VL 119 IS 2 BP 110 EP 115 DI 10.1152/japplphysiol.00068.2015 PG 6 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA CM8LL UT WOS:000357952300002 PM 25977447 ER PT J AU Xu, YH Wen, Y Zhu, YJ Gaskell, K Cychosz, KA Eichhorn, B Xu, K Wang, CS AF Xu, Yunhua Wen, Yang Zhu, Yujie Gaskell, Karen Cychosz, Katie A. Eichhorn, Bryan Xu, Kang Wang, Chunsheng TI Confined Sulfur in Microporous Carbon Renders Superior Cycling Stability in Li/S Batteries SO ADVANCED FUNCTIONAL MATERIALS LA English DT Article ID RECHARGEABLE LITHIUM BATTERIES; LONG LIFE-SPAN; S BATTERIES; CATHODE MATERIALS; ELEMENTAL SULFUR; HIGH-CAPACITY; ELECTROLYTE; POLYSULFIDE; PERFORMANCE; NANOTUBES AB The use of sulfur in the next generation Li-ion batteries is currently precluded by its poor cycling stability caused by irreversible Li2S formation and the dissolution of soluble polysulfides in organic electrolytes that leads to parasitic cell reactions. Here, a new C/S cathode material comprising short-chain sulfur species (predominately S-2) confined in carbonaceous subnanometer and the unique charge mechanism for the subnano-entrapped S-2 cathodes are reported. The first charge-discharge cycle of the C/S cathode in the carbonate electrolyte forms a new type of thiocarbonate-like solid electrolyte interphase (SEI). The SEI coated C/S cathode stably delivers approximate to 600 mAh g(-1) capacity over 4020 cycles (0.0014% loss cycle(-1)) at approximate to 100% Coulombic efficiency. Extensive X-ray photoelectron spectroscopy analysis of the discharged cathodes shows a new type of S-2 species and a new carbide-like species simultaneously, and both peaks disappear upon charging. These data suggest a new sulfur redox mechanism involving a separated Li+/S2- ion couple that precludes Li2S compound formation and prevents the dissolution of soluble sulfur anions. This new charge/discharge process leads to remarkable cycling stability and reversibility. C1 [Xu, Yunhua; Wen, Yang; Zhu, Yujie; Wang, Chunsheng] Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA. [Gaskell, Karen; Eichhorn, Bryan] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA. [Cychosz, Katie A.] Quantachrome Instruments, Boynton Beach, FL 33426 USA. [Xu, Kang] US Army Res Lab, Electrochem Branch, Power & Energy Div Sensor, Adelphi, MD 20783 USA. [Xu, Kang] US Army Res Lab, Electron Devices Directorate, Adelphi, MD 20783 USA. RP Xu, YH (reprint author), Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA. EM eichhorn@umd.edu; conrad.k.xu.civ@mail.mil; cswang@umd.edu RI Wang, Chunsheng/H-5767-2011 OI Wang, Chunsheng/0000-0002-8626-6381 FU Nanostructures for Electrical Energy Storage (NEES), an Energy Frontier Research Center - U.S. Department of Energy, Office of Science, Basic Energy Sciences [DESC0001160] FX This work was supported as part of the Nanostructures for Electrical Energy Storage (NEES), an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science, Basic Energy Sciences under Award number DESC0001160. NR 54 TC 42 Z9 42 U1 30 U2 287 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 1616-301X EI 1616-3028 J9 ADV FUNCT MATER JI Adv. Funct. Mater. PD JUL 15 PY 2015 VL 25 IS 27 BP 4312 EP 4320 DI 10.1002/adfm.201500983 PG 9 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA CM9AG UT WOS:000357996600015 ER PT J AU Carra, JH Martins, KAO Schokman, RD Robinson, CG Steffens, JT Bavari, S AF Carra, John H. Martins, Karen A. O. Schokman, Rowena D. Robinson, Camenzind G. Steffens, Jesse T. Bavari, Sina TI A thermostable, chromatographically purified Ebola nano-VLP vaccine SO JOURNAL OF TRANSLATIONAL MEDICINE LA English DT Article DE Filovirus; vaccine; Ebola; Virus-like particle; Immunogenicity; Thermostability ID VIRUS-LIKE PARTICLES; FILOVIRUS-LIKE PARTICLES; CANCER VACCINES; NANOPARTICLES; PROTECTION; DISCOVERY; ANTIBODY; SIZE AB Background: Filovirus virus-like particles (VLP) are strong immunogens with the potential for development into a safe, non-infectious vaccine. However, the large size and filamentous structure of this virus has heretofore made production of such a vaccine difficult. Herein, we present new assays and a purification procedure to yield a better characterized and more stable product. Methods: Sonication of VLP was used to produce smaller "nano-VLP", which were purified by membrane chromatography. The sizes and lengths of VLP particles were analyzed using electron microscopy and an assay based on transient occlusion of a nanopore. Using conformationally-sensitive antibodies, we developed an in vitro assay for measuring GP conformational integrity in the context of VLP, and used it to profile thermal stability. Results: We developed a new procedure for rapid isolation of Ebola VLP using membrane chromatography that yields a filterable and immunogenic product. Disruption of VLP filaments by sonication followed by filtration produced smaller particles of more uniform size, having a mean diameter close to 230 nm. These reduced-size VLP retained GP conformation and were protective against mouse-adapted Ebola challenge in mice. The "nano-VLP" consists of GP-coated particles in a mixture of morphologies including circular, branched, "6"-shaped, and filamentous ones up to similar to 1,500 nm in length. Lyophilization conferred a high level of thermostability on the nano-VLP. Unlike Ebola VLP in solution, which underwent denaturation of GP upon moderate heating, the lyophilized nano-VLP can withstand at least 1 h at 75 degrees C, while retaining conformational integrity of GP and the ability to confer protective immunity in a mouse model. Conclusions: We showed that Ebola virus-like particles can be reduced in size to a more amenable range for manipulation, and that these smaller particles retained their temperature stability, the structure of the GP antigen, and the ability to stimulate a protective immune response in mice. We developed a new purification scheme for "nano-VLP" that is more easily scaled up and filterable. The product could also be made thermostable by lyophilization, which is highly significant for vaccines used in tropical countries without a reliable "cold-chain" of refrigeration. C1 [Carra, John H.; Martins, Karen A. O.; Schokman, Rowena D.; Steffens, Jesse T.; Bavari, Sina] US Army, Med Res Inst Infect Dis, Mol & Translat Sci, Ft Detrick, MD 21702 USA. [Robinson, Camenzind G.] US Army, Med Res Inst Infect Dis, Div Pathol, Ft Detrick, MD 21702 USA. RP Carra, JH (reprint author), US Army, Med Res Inst Infect Dis, Mol & Translat Sci, Ft Detrick, MD 21702 USA. EM john.h.carra.civ@mail.mil FU Joint Science and Technology Office Defense Threat Reduction Agency (JSTO-DTRA) [CBM.VAXV.03.11.RD.009]; Joint Project Management Office of Medical Countermeasure Systems (JPM-MCS) [B.11, B.14] FX We thank Dr. David Hone for helpful suggestions, Dr. John Dye for antibodies used in this study, Dr. Andres Salazar of Oncovir for the poly-ICLC (Hiltonol), Steven Kern for statistics and Kathy Kuehl for EM sample preparation. Opinions, interpretations, conclusions, and recommendations are those of the author and are not necessarily endorsed by the U.S. Army. Funding was provided by the Joint Science and Technology Office Defense Threat Reduction Agency (JSTO-DTRA) #CBM.VAXV.03.11.RD.009 and the Joint Project Management Office of Medical Countermeasure Systems (JPM-MCS) #B.11 and B.14. NR 27 TC 2 Z9 2 U1 0 U2 7 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1479-5876 J9 J TRANSL MED JI J. Transl. Med. PD JUL 15 PY 2015 VL 13 AR 228 DI 10.1186/s12967-015-0593-y PG 14 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA CM8VK UT WOS:000357980200002 PM 26174690 ER PT J AU Jeldres, C Cullen, J Hurwitz, LM Wolff, EM Levie, KE Odem-Davis, K Johnston, RB Pham, KN Rosner, IL Brand, TC L'Esperance, JO Sterbis, JR Etzioni, R Porter, CR AF Jeldres, Claudio Cullen, Jennifer Hurwitz, Lauren M. Wolff, Erika M. Levie, Katherine E. Odem-Davis, Katherine Johnston, Richard B. Pham, Khanh N. Rosner, Inger L. Brand, Timothy C. L'Esperance, James O. Sterbis, Joseph R. Etzioni, Ruth Porter, Christopher R. TI Prospective quality-of-life outcomes for low-risk prostate cancer: Active surveillance versus radical prostatectomy SO CANCER LA English DT Article DE active surveillance; prostate cancer; quality of life; radical prostatectomy; survivorship ID MEN; CARE; MANAGEMENT; DIAGNOSIS; SURVIVORS; ANXIETY; MODELS; TRIAL AB BACKGROUNDFor patients with low-risk prostate cancer (PCa), active surveillance (AS) may produce oncologic outcomes comparable to those achieved with radical prostatectomy (RP). Health-related quality-of-life (HRQoL) outcomes are important to consider, yet few studies have examined HRQoL among patients with PCa who were managed with AS. In this study, the authors compared longitudinal HRQoL in a prospective, racially diverse, and contemporary cohort of patients who underwent RP or AS for low-risk PCa. METHODSBeginning in 2007, HRQoL data from validated questionnaires (the Expanded Prostate Cancer Index Composite and the 36-item RAND Medical Outcomes Study short-form survey) were collected by the Center for Prostate Disease Research in a multicenter national database. Patients aged 75 years who were diagnosed with low-risk PCa and elected RP or AS for initial disease management were followed for 3 years. Mean scores were estimated using generalized estimating equations adjusting for baseline HRQoL, demographic characteristics, and clinical patient characteristics. RESULTSOf the patients with low-risk PCa, 228 underwent RP, and 77 underwent AS. Multivariable analysis revealed that patients in the RP group had significantly worse sexual function, sexual bother, and urinary function at all time points compared with patients in the AS group. Differences in mental health between groups were below the threshold for clinical significance at 1 year. CONCLUSIONSIn this study, no differences in mental health outcomes were observed, but urinary and sexual HRQoL were worse for patients who underwent RP compared with those who underwent AS for up to 3 years. These data offer support for the management of low-risk PCa with AS as a means for postponing the morbidity associated with RP without concomitant declines in mental health. Cancer 2015;121:2465-2473. (c) 2015 American Cancer Society. Patients who undergo surgery for low-risk prostate cancer experience worse urinary and sexual function yet have similar mental health outcomes compared with patients on active surveillance. These results support the use of active surveillance for low-risk patients who seek to maintain their quality of life after prostate cancer diagnosis. C1 [Jeldres, Claudio; Wolff, Erika M.; Johnston, Richard B.; Pham, Khanh N.; Porter, Christopher R.] Virginia Mason, Sect Urol & Renal Transplantat, Seattle, WA USA. [Jeldres, Claudio] Univ Sherbrooke, Sherbrooke, PQ J1K 2R1, Canada. [Cullen, Jennifer; Hurwitz, Lauren M.; Levie, Katherine E.; Rosner, Inger L.; Brand, Timothy C.; L'Esperance, James O.; Sterbis, Joseph R.; Porter, Christopher R.] Ctr Prostate Dis Res, Dept Def, Rockville, MD 20852 USA. [Cullen, Jennifer; Hurwitz, Lauren M.; Levie, Katherine E.] Uniformed Serv Univ Hlth Sci, Henry M Jackson Fdn Adv Mil Med, Bethesda, MD 20814 USA. [Cullen, Jennifer] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. [Odem-Davis, Katherine] Univ Washington, Ctr Biomed Stat, Seattle, WA 98195 USA. [Rosner, Inger L.] Walter Reed Natl Mil Med Ctr, Urol Serv, Bethesda, MD USA. [Brand, Timothy C.] Madigan Army Med Ctr, Dept Urol, Tacoma, WA 98431 USA. [L'Esperance, James O.] Naval Med Ctr San Diego, Dept Urol, San Diego, CA USA. [Sterbis, Joseph R.] Tripler Army Med Ctr, Dept Urol, Honolulu, HI 96859 USA. [Etzioni, Ruth] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USA. RP Cullen, J (reprint author), Ctr Prostate Dis Res, Dept Def, 1530 East Jefferson St, Rockville, MD 20852 USA. EM jcullen@cpdr.org FU Center for Prostate Disease Research; Uniformed Services University of the Health Sciences; National Institutes of Health [UL1TR000423] FX This research was funded through the Center for Prostate Disease Research and the Uniformed Services University of the Health Sciences. Contributions by K.O.-D. were supported in part by the National Institutes of Health (UL1TR000423). NR 33 TC 3 Z9 3 U1 1 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0008-543X EI 1097-0142 J9 CANCER-AM CANCER SOC JI Cancer PD JUL 15 PY 2015 VL 121 IS 14 BP 2465 EP 2473 DI 10.1002/cncr.29370 PG 9 WC Oncology SC Oncology GA CM0AI UT WOS:000357340200024 PM 25845467 ER PT J AU Bologna, M Svenkeson, A West, BJ Grigolini, P AF Bologna, Mauro Svenkeson, Adam West, Bruce J. Grigolini, Paolo TI Diffusion in heterogeneous media: An iterative scheme for finding approximate solutions to fractional differential equations with time-dependent coefficients SO JOURNAL OF COMPUTATIONAL PHYSICS LA English DT Article DE Fractional calculus; Strange kinetics; Anomalous diffusion; Fractional index expansion; Time-dependent coefficients ID STRANGE KINETICS; LEVY FLUCTUATIONS; RANDOM-WALK; SPACE AB Diffusion processes in heterogeneous media, and biological systems in particular, are riddled with the difficult theoretical issue of whether the true origin of anomalous behavior is renewal or memory, or a special combination of the two. Accounting for the possible mixture of renewal and memory sources of subdiffusion is challenging from a computational point of view as well. This problem is exacerbated by the limited number of techniques available for solving fractional diffusion equations with time-dependent coefficients. We propose an iterative scheme for solving fractional differential equations with time-dependent coefficients that is based on a parametric expansion in the fractional index. We demonstrate how this method can be used to predict the long-time behavior of nonautonomous fractional differential equations by studying the anomalous diffusion process arising from a mixture of renewal and memory sources. (C) 2014 Elsevier Inc. All rights reserved. C1 [Bologna, Mauro] Univ Tarapaca, Inst Alta Invest, Arica, Chile. [Svenkeson, Adam; Grigolini, Paolo] Univ N Texas, Ctr Nonlinear Sci, Denton, TX 76203 USA. [Svenkeson, Adam] Army Res Lab, Adelphi, MD 20783 USA. [West, Bruce J.] Army Res Off, Informat Sci Directorate, Res Triangle Pk, NC 27709 USA. RP Svenkeson, A (reprint author), Univ N Texas, Ctr Nonlinear Sci, Denton, TX 76203 USA. EM mauroh69@gmail.com; adam.j.svenkeson.ctr@mail.mil; bruce.j.west.civ@mail.mil; grigo@unt.edu FU ARO [W911NF-11-1-0478]; Welch Foundation [B-1577]; FONDECYT [1120344] FX A.S. and P.G. warmly thank ARO and Welch Foundation for their support through Grants No. W911NF-11-1-0478 and No. B-1577, respectively. M.B. acknowledges financial support from FONDECYT project No. 1120344. NR 48 TC 2 Z9 2 U1 2 U2 21 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0021-9991 EI 1090-2716 J9 J COMPUT PHYS JI J. Comput. Phys. PD JUL 15 PY 2015 VL 293 SI SI BP 297 EP 311 DI 10.1016/j.jcp.2014.08.0270021 PG 15 WC Computer Science, Interdisciplinary Applications; Physics, Mathematical SC Computer Science; Physics GA CH6BC UT WOS:000354119500023 ER PT J AU Chan, MK Krebs, MO Cox, D Guest, PC Yolken, RH Rahmoune, H Rothermundt, M Steiner, J Leweke, FM van Beveren, NJM Niebuhr, DW Weber, NS Cowan, DN Suarez-Pinilla, P Crespo-Facorro, B Mam-Lam-Fook, C Bourgin, J Wenstrup, RJ Kaldate, RR Cooper, JD Bahn, S AF Chan, M. K. Krebs, M-O Cox, D. Guest, P. C. Yolken, R. H. Rahmoune, H. Rothermundt, M. Steiner, J. Leweke, F. M. van Beveren, N. J. M. Niebuhr, D. W. Weber, N. S. Cowan, D. N. Suarez-Pinilla, P. Crespo-Facorro, B. Mam-Lam-Fook, C. Bourgin, J. Wenstrup, R. J. Kaldate, R. R. Cooper, J. D. Bahn, S. TI Development of a blood-based molecular biomarker test for identification of schizophrenia before disease onset SO TRANSLATIONAL PSYCHIATRY LA English DT Article ID ULTRA-HIGH RISK; BIPOLAR DISORDER; 1ST EPISODE; PSYCHOSIS; SERUM; METAANALYSIS; INDIVIDUALS; EXPRESSION; SYMPTOMS; LEVEL AB Recent research efforts have progressively shifted towards preventative psychiatry and prognostic identification of individuals before disease onset. We describe the development of a serum biomarker test for the identification of individuals at risk of developing schizophrenia based on multiplex immunoassay profiling analysis of 957 serum samples. First, we conducted a meta-analysis of five independent cohorts of 127 first-onset drug-naive schizophrenia patients and 204 controls. Using least absolute shrinkage and selection operator regression, we identified an optimal panel of 26 biomarkers that best discriminated patients and controls. Next, we successfully validated this biomarker panel using two independent validation cohorts of 93 patients and 88 controls, which yielded an area under the curve (AUC) of 0.97 (0.95-1.00) for schizophrenia detection. Finally, we tested its predictive performance for identifying patients before onset of psychosis using two cohorts of 445 pre-onset or at-risk individuals. The predictive performance achieved by the panel was excellent for identifying USA military personnel (AUC: 0.90 (0.86-0.95)) and help-seeking prodromal individuals (AUC: 0.82 (0.71-0.93)) who developed schizophrenia up to 2 years after baseline sampling. The performance increased further using the latter cohort following the incorporation of CAARMS (Comprehensive Assessment of At-Risk Mental State) positive subscale symptom scores into the model (AUC: 0.90 (0.82-0.98)). The current findings may represent the first successful step towards a test that could address the clinical need for early intervention in psychiatry. Further developments of a combined molecular/symptom-based test will aid clinicians in the identification of vulnerable patients early in the disease process, allowing more effective therapeutic intervention before overt disease onset. C1 [Chan, M. K.; Cox, D.; Guest, P. C.; Rahmoune, H.; Cooper, J. D.; Bahn, S.] Univ Cambridge, Dept Chem Engn & Biotechnol, Cambridge CB2 1QT, England. [Krebs, M-O; Mam-Lam-Fook, C.; Bourgin, J.] Inst Psychiat, Ctr Psychiat & Neurosci, Lab Pathophysiol Psychiat Disorders, INSERM,UMR 894,GDR 3557, Paris, France. [Krebs, M-O; Mam-Lam-Fook, C.; Bourgin, J.] Univ Paris 05, Ctr Hosp St Anne, Serv Hosp Univ, Sorbonne Paris Cite,Fac Med Paris Descartes, Paris, France. [Yolken, R. H.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. [Rothermundt, M.] Univ Munster, Munster, Germany. [Rothermundt, M.] Evangel Klinikum Niederrhein, Oberhausen, Germany. [Steiner, J.] Univ Magdeburg, Dept Psychiat, D-39106 Magdeburg, Germany. [Leweke, F. M.] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Mannheim, Germany. [van Beveren, N. J. M.; Bahn, S.] Erasmus MC, Dept Neurosci, Rotterdam, Netherlands. [Niebuhr, D. W.; Weber, N. S.; Cowan, D. N.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Suarez-Pinilla, P.; Crespo-Facorro, B.] Univ Cantabria, Univ Hosp Marques de Valdecilla, Dept Psychiat, CIBERSAM,IDIVAL, E-39005 Santander, Spain. [Wenstrup, R. J.; Kaldate, R. R.] Myriad Genet Labs Inc, Salt Lake City, UT USA. RP Bahn, S (reprint author), Univ Cambridge, Dept Chem Engn & Biotechnol, Tennis Court Rd, Cambridge CB2 1QT, England. EM sb209@cam.ac.uk FU Stanley Medical Research Institute [07R-1888]; EU-FP7 SchizDX; French Ministry PHRC [AOM 07-118]; Fondation Deniker; Fondation pour la Recherche Medicale; Wenceslao Lopez-Albo fellowship (IDIVAL, Valdecilla Biomedical Research Institute, Santander, Spain); US Department of the Army FX MKC, PCG, RHY, HR, JDC, SB and DC were supported by grants from the Stanley Medical Research Institute (no. 07R-1888) and the EU-FP7 SchizDX. M-OK, JB and CM-L-F were supported by a grant from the French Ministry PHRC AOM 07-118, Fondation Deniker, Fondation pour la Recherche Medicale. PS-P and BC-F were supported by a Wenceslao Lopez-Albo fellowship (IDIVAL, Valdecilla Biomedical Research Institute, Santander, Spain). DWN, NSW and DNC were supported by the US Department of the Army. The funding organizations had no role in the design and conduct of the study; the collection, management, analysis and interpretation of the data; or the preparation or approval of the manuscript. We also thank all the patients, help-seekers and healthy volunteers for their selfless contribution to this study. NR 43 TC 18 Z9 18 U1 6 U2 14 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 2158-3188 J9 TRANSL PSYCHIAT JI Transl. Psychiatr. PD JUL 14 PY 2015 VL 5 AR e601 DI 10.1038/tp.2015.91 PG 10 WC Psychiatry SC Psychiatry GA DA2XN UT WOS:000367660600003 PM 26171982 ER PT J AU Jangu, C Savage, AM Zhang, ZY Schultz, AR Madsen, LA Beyer, FL Long, TE AF Jangu, Chainika Savage, Alice M. Zhang, Zhiyang Schultz, Alison R. Madsen, Louis A. Beyer, Frederick L. Long, Timothy E. TI Sulfonimide-Containing Triblock Copolymers for Improved Conductivity and Mechanical Performance SO MACROMOLECULES LA English DT Article ID CONTAINING ELECTROACTIVE MEMBRANES; RECHARGEABLE LITHIUM BATTERIES; PHOSPHONIUM IONIC LIQUID; POLYMER ELECTROLYTES; RADICAL POLYMERIZATION; MORPHOLOGY; TRANSPORT; LITFSI AB Ion-containing block copolymers continue to attract significant interest as conducting membranes in energy storage devices. Reversible addition-fragmentation chain transfer (RAFT) polymerization enables the synthesis of well-defined ionomeric A-BC-A triblock copolymers, featuring a microphase-separated morphology and a combination of excellent mechanical properties and high ion transport. The soft central "BC" block is composed of poly(4-styrenesulfonyl-(trifluoromethylsulfonyl)imide) (poly(Sty-Tf2N)) with -SO2-N--SO2-CF3 anionic groups associated with,a mobile lithium cation and low-T-g di(ethylene glycol)methyl ether methacrylate (DEGMEMA) units. External polystyrene A blocks provide mechanical strength with nanoscale morphology even at high ion content. Electrochemical impedance spectroscopy (EIS) and pulse-field-gradient (PFG) NMR spectroscopy have clarified the ion transport properties of these ionomeric A-BC-A triblock copolymers. Results confirmed that well-defined ionomeric A-BC-A triblock copolymers combine improved ion-transport properties with mechanical stability with significant potential for application in energy storage devices. C1 [Jangu, Chainika; Zhang, Zhiyang; Schultz, Alison R.; Madsen, Louis A.; Long, Timothy E.] Virginia Tech, Dept Chem, Blacksburg, VA 24061 USA. [Jangu, Chainika; Zhang, Zhiyang; Schultz, Alison R.; Madsen, Louis A.; Long, Timothy E.] Virginia Tech, MII, Blacksburg, VA 24061 USA. [Savage, Alice M.; Beyer, Frederick L.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Long, TE (reprint author), Virginia Tech, Dept Chem, Blacksburg, VA 24061 USA. EM telong@vt.edu FU US National Science Foundation [DMR 1507764]; Postgraduate Research Participation Program at the US Army Research Laboratory; US Department of Energy [ORISE1120-1120-99]; Army Research Laboratory [ORISE1120-1120-99] FX The PFG NMR diffusometry work was supported in part by the US National Science Foundation under Award DMR 1507764. We acknowledge Solvay for providing Tf2N-based ionic liquids used in the research. A.M.S. was supported by the Postgraduate Research Participation Program at the US Army Research Laboratory, administered by the Oak Ridge Institute of Science and Education through an interagency agreement between the US Department of Energy and Army Research Laboratory (Contract ORISE1120-1120-99). We also acknowledge Dr. Ken Sakaushi at National Institute of Materials Science, Japan, for insightful discussions on this research. NR 46 TC 13 Z9 13 U1 7 U2 64 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0024-9297 EI 1520-5835 J9 MACROMOLECULES JI Macromolecules PD JUL 14 PY 2015 VL 48 IS 13 BP 4520 EP 4528 DI 10.1021/acs.macromol.5b01009 PG 9 WC Polymer Science SC Polymer Science GA CN0LK UT WOS:000358104900031 ER PT J AU Schuster, J DeWames, RE DeCuir, EA Bellotti, E Wijewarnasuriya, PS AF Schuster, J. DeWames, R. E. DeCuir, E. A., Jr. Bellotti, E. Wijewarnasuriya, P. S. TI Junction optimization in HgCdTe: Shockley-Read-Hall generation-recombination suppression SO APPLIED PHYSICS LETTERS LA English DT Article ID PHOTODIODES; GEOMETRY AB Heterojunction device design concepts are leveraged to reduce depletion layer generation-recombination (G-R) dark current in planar P+-on-n SWIR HgCdTe infrared detectors. Shockley-Read-Hall (SRH) depletion dark current (when present) is expected to be the dominant dark current component at low temperatures, and in fact, it is beneficial for the transition from diffusion to G-R to be at such relatively low temperatures. However, it is empirically observed that even for relatively long values of the SRH lifetime (20 mu s), the transition occurs at relatively high temperatures (>200K) for material with a cut-off wavelength of 2:5 mu m. A key device design parameter of P+-on-n photodiodes is the position of the electrical junction relative to the hetero-metallurgical interface. Junction formation via p-type arsenic implantation into the narrow-gap absorber layer is typically chosen for efficient collection of diffusion current, however, other configurations are possible as well. In this letter, we numerically explore the conditions that reduce depletion dark current without reducing the quantum efficiency (QE). The findings support the assertion that device design conditions exist in SWIR HgCdTe that essentially eliminate the depletion dark current without significantly reducing the QE. (C) 2015 AIP Publishing LLC. C1 [Schuster, J.; DeCuir, E. A., Jr.; Wijewarnasuriya, P. S.] US Army Res Lab, Adelphi, MD 20783 USA. [Schuster, J.; Bellotti, E.] Boston Univ, Dept Elect & Comp Engn, Boston, MA 02215 USA. [DeWames, R. E.] Fulcrum Co, Centreville, VA 20120 USA. RP Schuster, J (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM jonathan.schuster2.ctr@mail.mil OI Schuster, Jonathan/0000-0002-0835-5733 NR 16 TC 8 Z9 8 U1 4 U2 24 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUL 13 PY 2015 VL 107 IS 2 AR 023502 DI 10.1063/1.4926603 PG 5 WC Physics, Applied SC Physics GA CN6FS UT WOS:000358530300050 ER PT J AU Files, BT Tjan, BS Jiang, JT Bernstein, LE AF Files, Benjamin T. Tjan, Bosco S. Jiang, Jintao Bernstein, Lynne E. TI Visual speech discrimination and identification of natural and synthetic consonant stimuli SO FRONTIERS IN PSYCHOLOGY LA English DT Article DE visual speech perception; visemes; lipreading/speechreading; discrimination; synthetic visual speech; motion capture; multisensory perception; audiovisual speech perception ID VOICE FUNDAMENTAL-FREQUENCY; AUDIOVISUAL SPEECH; WORD-RECOGNITION; SPEECHREADING SENTENCES; LEXICAL DISTINCTIVENESS; MISMATCH NEGATIVITY; FACE RECOGNITION; NORMAL-HEARING; PERCEPTION; INVERSION AB From phonetic features to connected discourse, every level of psycholinguistic structure including prosody can be perceived through viewing the talking face. Yet a longstanding notion in the literature is that visual speech perceptual categories comprise groups of phonemes (referred to as visemes), such as /p, b, m/ and /f, v/, whose internal structure is not informative to the visual speech perceiver. This conclusion has not to our knowledge been evaluated using a psychophysical discrimination paradigm. We hypothesized that perceivers can discriminate the phonemes within typical viseme groups, and that discrimination measured with d-prime (d') and response latency is related to visual stimulus dissimilarities between consonant segments. In Experiment 1, participants performed speeded discrimination for pairs of consonant-vowel spoken nonsense syllables that were predicted to be same, near, or far in their perceptual distances, and that were presented as natural or synthesized video. Near pairs were within-viseme consonants. Natural within-viseme stimulus pairs were discriminated significantly above chance (except for /k/-/h/). Sensitivity (d') increased and response times decreased with distance. Discrimination and identification were superior with natural stimuli, which comprised more phonetic information. We suggest that the notion of the viseme as a unitary perceptual category is incorrect. Experiment 2 probed the perceptual basis for visual speech discrimination by inverting the stimuli. Overall reductions in d' with inverted stimuli but a persistent pattern of larger d' for far than for near stimulus pairs are interpreted as evidence that visual speech is represented by both its motion and configural attributes. The methods and results of this investigation open up avenues for understanding the neural and perceptual bases for visual and audiovisual speech perception and for development of practical applications such as visual lipreading/speechreading speech synthesis. C1 [Files, Benjamin T.] US Army, Human Res & Engn Directorate, Res Lab, Aberdeen Proving Ground, MD USA. [Tjan, Bosco S.] Univ So Calif, Dept Psychol, Los Angeles, CA 90089 USA. [Jiang, Jintao] Applicat Technol, Mclean, VA USA. [Bernstein, Lynne E.] George Washington Univ, Dept Speech & Hearing Sci, Washington, DC 20052 USA. RP Bernstein, LE (reprint author), George Washington Univ, Dept Speech & Hearing Sci, Washington, DC 20052 USA. EM lbemste@gwu.edu FU NIH/NIDCD [R01 DC008583, R01 DC012634]; NIH [T32DC009975] FX Research reported in this publication was supported by NIH/NIDCD R01 DC008583 and R01 DC012634 (Bernstein, PI). Author BF was supported in addition by NIH Training Grant T32DC009975. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The authors thank the technicians and the participants who helped in carrying out the experiments. NR 93 TC 0 Z9 0 U1 7 U2 16 PU FRONTIERS MEDIA SA PI LAUSANNE PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLAND SN 1664-1078 J9 FRONT PSYCHOL JI Front. Psychol. PD JUL 13 PY 2015 VL 6 AR 878 DI 10.3389/fpsyg.2015.00878 PG 18 WC Psychology, Multidisciplinary SC Psychology GA CM8VR UT WOS:000357981000001 PM 26217249 ER PT J AU Perovich, DK Richter-Menge, JA AF Perovich, Donald K. Richter-Menge, Jacqueline A. TI Regional variability in sea ice melt in a changing Arctic SO PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES LA English DT Article DE Arctic sea ice; ice melt; surface melting; bottom melting; sea ice loss ID MASS-BALANCE BUOYS; COVER; THICKNESS; RETREAT AB In recent years, the Arctic sea ice cover has undergone a precipitous decline in summer extent. The sea ice mass balance integrates heat and provides insight on atmospheric and oceanic forcing. The amount of surface melt and bottom melt that occurs during the summer melt season was measured at 41 sites over the time period 1957 to 2014. There are large regional and temporal variations in both surface and bottom melting. Combined surface and bottom melt ranged from 16 to 294 cm, with a mean of 101 cm. The mean ice equivalent surface melt was 48 cm and the mean bottom melt was 53 cm. On average, surface melting decreases moving northward from the Beaufort Sea towards the North Pole; however interannual differences in atmospheric forcing can overwhelm the influence of latitude. Substantial increases in bottom melting are a major contributor to ice losses in the Beaufort Sea, due to decreases in ice concentration. In the central Arctic, surface and bottom melting demonstrate interannual variability, but show no strong temporal trends from 2000 to 2014. This suggests that under current conditions, summer melting in the central Arctic is not large enough to completely remove the sea ice cover. C1 [Perovich, Donald K.] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. [Perovich, Donald K.; Richter-Menge, Jacqueline A.] ERDC CRREL, Hanover, NH 03755 USA. RP Perovich, DK (reprint author), Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. EM donald.k.perovich@usace.army.mil FU United States National Science Foundation; National Oceanographic and Atmospheric Administration FX The authors thank the United States National Science Foundation and the National Oceanographic and Atmospheric Administration for their continued support of these sea ice mass balance studies. NR 40 TC 3 Z9 3 U1 6 U2 24 PU ROYAL SOC PI LONDON PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND SN 1364-503X EI 1471-2962 J9 PHILOS T R SOC A JI Philos. Trans. R. Soc. A-Math. Phys. Eng. Sci. PD JUL 13 PY 2015 VL 373 IS 2045 AR 20140165 DI 10.1098/rsta.2014.0165 PG 12 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CM0BM UT WOS:000357343200006 ER PT J AU Mayo, M Collier, ZA Winton, C Chappell, MA AF Mayo, Michael Collier, Zachary A. Winton, Corey Chappell, Mark A. TI Data-Driven Method to Estimate Nonlinear Chemical Equivalence SO PLOS ONE LA English DT Article ID LIFE-CYCLE ASSESSMENT; RISK-ASSESSMENT; SELENIUM TOXICITY; IMPACT ASSESSMENT; DECISION-ANALYSIS; MULTIMEDIA FATE; SUBSTANCES; POTENTIALS; FRAMEWORK; NETWORKS AB There is great need to express the impacts of chemicals found in the environment in terms of effects from alternative chemicals of interest. Methods currently employed in fields such as life-cycle assessment, risk assessment, mixtures toxicology, and pharmacology rely mostly on heuristic arguments to justify the use of linear relationships in the construction of "equivalency factors," which aim to model these concentration-concentration correlations. However, the use of linear models, even at low concentrations, oversimplifies the nonlinear nature of the concentration-response curve, therefore introducing error into calculations involving these factors. We address this problem by reporting a method to determine a concentration-concentration relationship between two chemicals based on the full extent of experimentally derived concentration-response curves. Although this method can be easily generalized, we develop and illustrate it from the perspective of toxicology, in which we provide equations relating the sigmoid and non-monotone, or "biphasic," responses typical of the field. The resulting concentration-concentration relationships are manifestly nonlinear for nearly any chemical level, even at the very low concentrations common to environmental measurements. We demonstrate the method using real-world examples of toxicological data which may exhibit sigmoid and biphasic mortality curves. Finally, we use our models to calculate equivalency factors, and show that traditional results are recovered only when the concentration-response curves are "parallel," which has been noted before, but we make formal here by providing mathematical conditions on the validity of this approach. C1 [Mayo, Michael; Collier, Zachary A.; Chappell, Mark A.] US Army, Environm Lab, Engn Res & Dev Ctr, Vicksburg, MS 39183 USA. [Winton, Corey] US Army, Informat Technol Lab, Engn Res & Dev Ctr, Vicksburg, MS 39183 USA. RP Mayo, M (reprint author), US Army, Environm Lab, Engn Res & Dev Ctr, Vicksburg, MS 39183 USA. EM Michael.L.Mayo@usace.army.mil FU Military Materials in the Environment (MME) Program for the U.S Army Engineer Research & Development (ERDC) Laboratory FX This work was funded through the Military Materials in the Environment (MME) Program for the U.S Army Engineer Research & Development (ERDC) Laboratory. NR 49 TC 2 Z9 2 U1 2 U2 8 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUL 9 PY 2015 VL 10 IS 7 AR e0130494 DI 10.1371/journal.pone.0130494 PG 24 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CN1EW UT WOS:000358161200012 PM 26158701 ER PT J AU Wang, GX Loh, GC Pandey, R Karna, SP AF Wang, Gaoxue Loh, G. C. Pandey, Ravindra Karna, Shashi P. TI Novel Two-Dimensional Silica Monolayers with Tetrahedral and Octahedral Configurations SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID HIGH-PRESSURE; ATOMIC-STRUCTURE; ELECTRONIC-PROPERTIES; CRYSTAL-STRUCTURE; FILMS; GRAPHENE; PHASE; GLASS; SIO2; POLYMORPHISM AB Freestanding and well-ordered two-dimensional (2D) silica monolayers with tetrahedral (T-silica) and octahedral (O-silica) building blocks are found to be stable by first-principles calculations. T-silica is formed by corner-sharing SiO4 tetrahedrons in a rectangular network, and O-silica consists of edge-sharing SiO6 octahedrons. Moreover, the insulating O-silica is the strongest silica monolayer, and can therefore act as a supporting substrate for nanostructures in sensing and catalytic applications. Nanoribbons of T-silica are metallic, while those of O-silica have band gaps regardless of the chirality and width. We find the interaction of O-silica with graphene to be weak, suggesting the possibility of its use as a monolayer dielectric material for graphene-based devices. Considering that the sixfold-coordinated silica exists at high pressure in the bulk phase, the prediction of a small energy difference of O-silica with the synthesized silica bilayer, together with the thermal stability at 1000 K, suggests that synthesis of O-silica can be achieved in experiments. C1 [Wang, Gaoxue; Loh, G. C.; Pandey, Ravindra] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. [Loh, G. C.] Inst High Performance Comp, Singapore 138632, Singapore. [Karna, Shashi P.] US Army Res Lab, Weap & Mat Res Directorate, ATTN RDRL WM, Aberdeen Proving Ground, MD 21005 USA. RP Pandey, R (reprint author), Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. EM pandey@mtu.edu RI Wang, Gaoxue/C-9492-2017 OI Wang, Gaoxue/0000-0003-2539-3405 FU Army Research Office [W911NF-14-2-0088] FX Helpful discussions with S. Gowtham are acknowledged. RAMA and Superior, high performance computing clusters at Michigan Technological University, were used in obtaining results presented in this paper. The authors appreciate D. R. Banyai for providing the code for STM simulation. This research was partially supported by the Army Research Office through Grant W911NF-14-2-0088. NR 50 TC 5 Z9 5 U1 6 U2 24 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD JUL 9 PY 2015 VL 119 IS 27 BP 15654 EP 15660 DI 10.1021/acs.jpcc.5b01646 PG 7 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA CM8PU UT WOS:000357964900094 ER PT J AU Beal, SA Osterberg, EC Zdanowicz, CM Fisher, DA AF Beal, Samuel A. Osterberg, Erich C. Zdanowicz, Christian M. Fisher, David A. TI Ice Core Perspective on Mercury Pollution during the Past 600 Years SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID ATMOSPHERIC MERCURY; ANTHROPOGENIC SOURCES; DEPOSITION; CANADA; EMISSIONS; HOLOCENE; RECORD; SNOW; AIR; ECOSYSTEM AB Past emissions of the toxic metal mercury (Fig) persist in the global environment yet these emissions remain poorly constrained by existing data. Ice cores are high-resolution archives of atmospheric deposition that may provide crucial insight into past atmospheric Hg levels during recent and historical time. Here we present a record of total Hg (Hg-T) in an ice core from the pristine summit plateau (5340 m asl) of Mount Logan, Yukon, Canada, representing atmospheric deposition from AD 1410 to 1998. The Colonial Period (similar to 1603-1850) and North American "Gold Rush" (1850-1900) represent minor fractions (8% and 14%, respectively) of total anthropogenic Hg deposition in the record, with the majority (78%) occurring during the 20th Century. A period of maximum HgT fluxes from 1940 to 1975 coincides with estimates of enhanced anthropogenic Hg emissions from commercial sources, as well as with industrial emissions of other toxic metals. Rapid declines in HgT fluxes following peaks during the Gold Rush and the mid-20th Century indicate that atmospheric Hg deposition responds quickly to reductions in emissions. Increasing HgT fluxes from 1993 until the youngest samples in 1998 may reflect the resurgence of Hg emissions from unregulated coal burning and small-scale gold mining. C1 [Beal, Samuel A.; Osterberg, Erich C.] Dartmouth Coll, Dept Earth Sci, Hanover, NH 03755 USA. [Zdanowicz, Christian M.] Uppsala Univ, Dept Earth Sci, S-75236 Uppsala, Sweden. [Fisher, David A.] Univ Ottawa, Dept Earth Sci, Ottawa, ON K1N 6N5, Canada. RP Beal, SA (reprint author), US Army Corps Engineers, Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM samuel.beal@usace.army.mil OI Zdanowicz, Christian/0000-0002-1045-5063 FU National Science Foundation [BCS-1232844] FX This material is based upon work supported by the National Science Foundation under Grant BCS-1232844. We thank the following collaborators: the Geological Survey of Canada for making the Mount Logan ice core available; T. Overly and G. Wong for ice core processing in Ottawa; Z. Courville for freezer access; B. Jackson and C. Lamborg for scientific insight; and J. Creswell and V. Engel at Brooks Rand Laboratories for instrument assistance. We also thank four anonymous reviewers. NR 46 TC 7 Z9 7 U1 5 U2 33 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD JUL 7 PY 2015 VL 49 IS 13 BP 7641 EP 7647 DI 10.1021/acs.est.5b01033 PG 7 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA CM6ZN UT WOS:000357840300019 PM 26011603 ER PT J AU Ashkar, R Nagao, M Butler, PD Woodka, AC Sen, MK Koga, T AF Ashkar, Rana Nagao, Michihiro Butler, Paul D. Woodka, Andrea C. Sen, Mani K. Koga, Tadanori TI Tuning Membrane Thickness Fluctuations in Model Lipid Bilayers SO BIOPHYSICAL JOURNAL LA English DT Article ID ANGLE NEUTRON-SCATTERING; PROTEIN FUNCTION; CHAIN-LENGTH; MONTE-CARLO; DYNAMICS; PHASE; RAFTS; FLUID; UNDULATIONS; SIMULATIONS AB Membrane thickness fluctuations have been associated with a variety of critical membrane phenomena, such as cellular exchange, pore formation, and protein binding, which are intimately related to cell functionality and effective pharmaceuticals. Therefore, understanding how these fluctuations are controlled can remarkably impact medical applications involving selective macromolecule binding and efficient cellular drug intake. Interestingly, previous reports on single-component bilayers show almost identical thickness fluctuation patterns for all investigated lipid tail-lengths, with similar temperature-independent membrane thickness fluctuation amplitude in the fluid phase and a rapid suppression of fluctuations upon transition to the gel phase. Presumably, in vivo functions require a tunability of these parameters, suggesting that more complex model systems are necessary. In this study, we explore lipid tail-length mismatch as a regulator for membrane fluctuations. Unilamellar vesicles of an equimolar mixture of dimyristoylphosphatidylcholine and distearoylphosphatidylcholine molecules, with different tail-lengths and melting transition temperatures, are used as a model system for this next level of complexity. Indeed, this binary system exhibits a significant response of membrane dynamics to thermal variations. The system also suggests a decoupling of the amplitude and the relaxation time of the membrane thickness fluctuations, implying a potential for independent control of these two key parameters. C1 [Ashkar, Rana; Nagao, Michihiro; Butler, Paul D.] NIST, Ctr Neutron Res, Gaithersburg, MD 20899 USA. [Ashkar, Rana] Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA. [Nagao, Michihiro] Indiana Univ, Ctr Explorat Energy & Matter, Bloomington, IN USA. [Butler, Paul D.] Univ Delaware, Dept Chem & Biomol Engn, Newark, DE USA. [Woodka, Andrea C.] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. [Sen, Mani K.; Koga, Tadanori] SUNY Stony Brook, Dept Mat Sci & Engn, Stony Brook, NY 11794 USA. [Koga, Tadanori] SUNY Stony Brook, Chem & Mol Engn Program, Stony Brook, NY 11794 USA. RP Nagao, M (reprint author), NIST, Ctr Neutron Res, Gaithersburg, MD 20899 USA. EM mnagao@indiana.edu RI Koga, Tadanori/A-4007-2010; Butler, Paul/D-7368-2011; OI Ashkar, Rana/0000-0003-4075-2330 FU National Institute of Standards and Technology (NIST), U.S. Department of Commerce [70NANB10H255]; U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences [DE-AC02-98CH10886] FX M.N. acknowledges funding support of cooperative agreement No. 70NANB10H255 from National Institute of Standards and Technology (NIST), U.S. Department of Commerce. The authors acknowledge the use of the NIST Center for Neutron Research facilities, which are supported in part by the National Science Foundation under agreement No. DMR-0944772. Use of the National Synchrotron Light Source was supported by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, under contract No. DE-AC02-98CH10886. NR 45 TC 4 Z9 4 U1 4 U2 35 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 0006-3495 EI 1542-0086 J9 BIOPHYS J JI Biophys. J. PD JUL 7 PY 2015 VL 109 IS 1 BP 106 EP 112 DI 10.1016/j.bpj.2015.05.033 PG 7 WC Biophysics SC Biophysics GA CM4QV UT WOS:000357670700013 PM 26153707 ER PT J AU Holt, KE Wertheim, H Zadoks, RN Baker, S Whitehouse, CA Dance, D Jenney, A Connor, TR Hsu, LY Severin, J Brisse, S Cao, HW Wilksch, J Gorrie, C Schultz, MB Edwards, DJ Nguyen, KV Nguyen, TV Dao, TT Mensinke, M Minh, VL Nhu, NTK Schultsz, C Kuntaman, K Newton, PN Moore, CE Strugnell, RA Thomson, NR AF Holt, Kathryn E. Wertheim, Heiman Zadoks, Ruth N. Baker, Stephen Whitehouse, Chris A. Dance, David Jenney, Adam Connor, Thomas R. Hsu, Li Yang Severin, Juliette Brisse, Sylvain Cao, Hanwei Wilksch, Jonathan Gorrie, Claire Schultz, Mark B. Edwards, David J. Kinh Van Nguyen Trung Vu Nguyen Trinh Tuyet Dao Mensinke, Martijn Vien Le Minh Nguyen Thi Khanh Nhu Schultsz, Constance Kuntaman, Kuntaman Newton, Paul N. Moore, Catrin E. Strugnell, Richard A. Thomson, Nicholas R. TI Genomic analysis of diversity, population structure, virulence, and antimicrobial resistance in Klebsiella pneumoniae, an urgent threat to public health SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE Klebsiella pneumoniae; genomics; virulence; antimicrobial resistance; population structure ID LIVER-ABSCESS; PHYLOGENETIC GROUPS; BETA-LACTAMASE; INFECTIONS; IDENTIFICATION; EPIDEMIOLOGY; EVOLUTION; STRAINS; K1; PREVALENCE AB Klebsiella pneumoniae is nowrecognized as an urgent threat to human health because of the emergence of multidrug-resistant strains associated with hospital outbreaks and hypervirulent strains associated with severe community-acquired infections. K. pneumoniae is ubiquitous in the environment and can colonize and infect both plants and animals. However, little is known about the population structure of K. pneumoniae, so it is difficult to recognize or understand the emergence of clinically important clones within this highly genetically diverse species. Here we present a detailed genomic framework for K. pneumoniae based on whole-genome sequencing of more than 300 human and animal isolates spanning four continents. Our data provide genome-wide support for the splitting of K. pneumoniae into three distinct species, KpI (K. pneumoniae), KpII (K. quasipneumoniae), and KpIII (K. variicola). Further, for K. pneumoniae (KpI), the entity most frequently associated with human infection, we show the existence of >150 deeply branching lineages including numerous multidrug-resistant or hypervirulent clones. We show K. pneumoniae has a large accessory genome approaching 30,000 protein-coding genes, including a number of virulence functions that are significantly associated with invasive community-acquired disease in humans. In our dataset, antimicrobial resistance genes were common among human carriage isolates and hospital-acquired infections, which generally lacked the genes associated with invasive disease. The convergence of virulence and resistance genes potentially could lead to the emergence of untreatable invasive K. pneumoniae infections; our data provide the whole-genome framework against which to track the emergence of such threats. C1 [Holt, Kathryn E.; Gorrie, Claire; Schultz, Mark B.; Edwards, David J.] Univ Melbourne, Dept Biochem & Mol Biol, Mol Sci & Biotechnol Inst Bio21, Parkville, Vic 3010, Australia. [Holt, Kathryn E.; Jenney, Adam; Cao, Hanwei; Wilksch, Jonathan; Gorrie, Claire; Strugnell, Richard A.] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3010, Australia. [Wertheim, Heiman] Univ Oxford, Clin Res Unit, Wellcome Trust Major Overseas Programme, Natl Hosp Trop Dis, Hanoi, Vietnam. [Wertheim, Heiman; Dance, David; Newton, Paul N.; Moore, Catrin E.] Univ Oxford, Ctr Trop Med, Nuffield Dept Clin Med, Oxford OX3 7BN, England. [Zadoks, Ruth N.; Mensinke, Martijn] Cornell Univ, Qual Milk Prod Serv, Ithaca, NY 14853 USA. [Zadoks, Ruth N.] Univ Glasgow, Coll Med Vet & Life Sci, Institute Biodivers Anim Hlth & Comparat Med, Glasgow G12 8QQ, Lanark, Scotland. [Baker, Stephen; Vien Le Minh; Nguyen Thi Khanh Nhu; Schultsz, Constance] Univ Oxford, Clin Res Unit, Hosp Trop Dis, Wellcome Trust Major Overseas Programme, Ho Chi Minh City, Vietnam. [Whitehouse, Chris A.] US Army Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Newton, Paul N.; Moore, Catrin E.] Mahosot Hosp, Microbiol Lab, Lao Oxford Mahosot Hosp Wellcome Trust Res Unit, Viangchan, Laos. [Jenney, Adam] Alfred Hosp, Dept Infect Dis, Melbourne, Vic 3004, Australia. [Jenney, Adam] Alfred Hosp, Microbiol Unit, Melbourne, Vic 3004, Australia. [Connor, Thomas R.; Thomson, Nicholas R.] Wellcome Trust Sanger Ctr, Pathogen Genom, Cambridge CB10 1SA, England. [Dance, David; Connor, Thomas R.] Cardiff Univ, Sch Biosci, Cardiff CF10 3AX, S Glam, Wales. [Hsu, Li Yang] Natl Univ Hlth Syst, Dept Med, Singapore 119228, Singapore. [Severin, Juliette] Erasmus Univ, Med Ctr, Dept Med Microbiol & Infect Dis, NL-3015 CE Rotterdam, Netherlands. [Brisse, Sylvain] CNRS, UMR3525, Inst Pasteur, Microbial Evolutionary Genom, Paris, France. [Cao, Hanwei; Wilksch, Jonathan; Gorrie, Claire; Strugnell, Richard A.] Univ Melbourne, Peter Doherty Inst, Parkville, Vic 3010, Australia. [Kinh Van Nguyen; Trung Vu Nguyen; Trinh Tuyet Dao] Natl Hosp Trop Dis, Hanoi, Vietnam. [Vien Le Minh] Univ Calif San Francisco, Dept Med, Div Infect Dis, San Francisco, CA 94118 USA. [Nguyen Thi Khanh Nhu] Univ Queensland, Sch Chem & Mol Biosci, Brisbane, Qld 4072, Australia. [Schultsz, Constance] Univ Amsterdam, Acad Med Ctr, NL-1012 WX Amsterdam, Netherlands. [Kuntaman, Kuntaman] Airlangga Univ, Sch Med, Dr Soetomo Acad Hosp, Dept Clin Microbiol, Surabaya, Jawa Timur, Indonesia. [Thomson, Nicholas R.] Univ London London Sch Hyg & Trop Med, Dept Pathogen Mol Biol, London WC1E 7HT, England. RP Holt, KE (reprint author), Univ Melbourne, Dept Biochem & Mol Biol, Mol Sci & Biotechnol Inst Bio21, Parkville, Vic 3010, Australia. EM kholt@unimelb.edu.au; nrt@sanger.ac.uk RI Holt, Kathryn/A-8108-2012; OI Holt, Kathryn/0000-0003-3949-2471; Strugnell, Richard/0000-0003-0614-5641; Connor, Thomas/0000-0003-2394-6504; Zadoks, Ruth/0000-0002-1164-8000; Schultz, Mark/0000-0002-7689-6531; Kuntaman, Kuntaman/0000-0003-4897-8879; Hsu, Li Yang/0000-0002-0396-066X; Dance, David/0000-0001-9189-7244 FU National Health and Medical Research Council of Australia [628930, 1061409, 606788]; Wellcome Trust [098051, 089275/H/09/Z]; Sir Henry Dale Fellowship; Royal Society; Victorian Life Sciences Computation Initiative Grant [VR0082] FX We thank the sequencing teams at the Wellcome Trust Sanger Institute (WTSI) for genome sequencing; Dr. Rattanaphone Phetsouvanh and the directors of Mahosot Hospital (Vientiane, Lao People's Democratic Republic) and Joy Silisouk for performing DNA extractions on the Lao strains; Associate Professor Tse Hsien Koh for isolates from the Singapore General Hospital (Singapore); T. Williammee and D. Sentochnik (Basett Healthcare) for human isolates from the United States; K. W. Simpson and B. Dogan (Cornell University) for isolates from human intestinal biopsies; and Brenda Werner and other staff at Quality Milk Production Services (Cornell University) for help in collecting and processing bovine and human samples from the United States. This work was funded by National Health and Medical Research Council of Australia Fellowships 628930 and 1061409 (to K. E. H.) and Program Grant 606788 (to R. A. S.); Wellcome Trust Grants 098051 (to the WTSI) and 089275/H/09/Z (to the Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit); Sir Henry Dale Fellowship (cofunded by the Royal Society) (to S. Baker); and by Victorian Life Sciences Computation Initiative Grant VR0082. NR 67 TC 48 Z9 50 U1 10 U2 34 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD JUL 7 PY 2015 VL 112 IS 27 BP E3574 EP E3581 DI 10.1073/pnas.1501049112 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CM2QU UT WOS:000357527600017 PM 26100894 ER PT J AU Mucker, EM Chapman, J Huzella, LM Huggins, JW Shamblin, J Robinson, CG Hensley, LE AF Mucker, Eric M. Chapman, Jennifer Huzella, Louis M. Huggins, John W. Shamblin, Joshua Robinson, Camenzind G. Hensley, Lisa E. TI Susceptibility of Marmosets (Callithrix jacchus) to Monkeypox Virus: A Low Dose Prospective Model for Monkeypox and Smallpox Disease SO PLOS ONE LA English DT Article ID NONHUMAN PRIMATE MODEL; VACCINIA VIRUS; POXVIRUS INFECTION; IN-VITRO; PROTECTION; COMPLEMENT; PATHOLOGY; VARIOLA; ST-246; VACCINATION AB Although current nonhuman primate models of monkeypox and smallpox diseases provide some insight into disease pathogenesis, they require a high titer inoculum, use an unnatural route of infection, and/or do not accurately represent the entire disease course. This is a concern when developing smallpox and/or monkeypox countermeasures or trying to understand host pathogen relationships. In our studies, we altered half of the test system by using a New World nonhuman primate host, the common marmoset. Based on dose finding studies, we found that marmosets are susceptible to monkeypox virus infection, produce a high viremia, and have pathological features consistent with smallpox and monkeypox in humans. The low dose (48 plaque forming units) required to elicit a uniformly lethal disease and the extended incubation (preclinical signs) are unique features among nonhuman primate models utilizing monkeypox virus. The uniform lethality, hemorrhagic rash, high viremia, decrease in platelets, pathology, and abbreviated acute phase are reflective of early-type hemorrhagic smallpox. C1 [Mucker, Eric M.; Huggins, John W.; Shamblin, Joshua] US Army Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21701 USA. [Chapman, Jennifer] Joint Pathol Ctr, Silver Spring, MD USA. [Huzella, Louis M.; Hensley, Lisa E.] NIAID, Integrated Res Facil, Ft Detrick, MD USA. [Robinson, Camenzind G.] US Army Med Res Inst Infect Dis, Div Pathol, Ft Detrick, MD USA. [Mucker, Eric M.] Tulane Univ, Sch Med, New Orleans, LA 70112 USA. RP Mucker, EM (reprint author), US Army Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21701 USA. EM eric.m.mucker.ctr@mail.mil FU United States Army Medical Research Institute of Infectious Diseases FX This work was internally funded by the United States Army Medical Research Institute of Infectious Diseases. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 46 TC 1 Z9 1 U1 0 U2 6 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUL 6 PY 2015 VL 10 IS 7 AR e0131742 DI 10.1371/journal.pone.0131742 PG 20 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CN1DQ UT WOS:000358157600139 PM 26147658 ER PT J AU Ockenhouse, CF Regules, J Tosh, D Cowden, J Kathcart, A Cummings, J Paolino, K Moon, J Komisar, J Kamau, E Oliver, T Chhoeu, A Murphy, J Lyke, K Laurens, M Birkett, A Lee, C Weltzin, R Wille-Reece, U Sedegah, M Hendriks, J Versteege, I Pau, MG Sadoff, J Vanloubbeeck, Y Lievens, M Heerwegh, D Moris, P Mendoza, YG Jongert, E Cohen, J Voss, G Ballou, WR Vekemans, J AF Ockenhouse, Christian F. Regules, Jason Tosh, Donna Cowden, Jessica Kathcart, April Cummings, James Paolino, Kristopher Moon, James Komisar, Jack Kamau, Edwin Oliver, Thomas Chhoeu, Austin Murphy, Jitta Lyke, Kirsten Laurens, Matthew Birkett, Ashley Lee, Cynthia Weltzin, Rich Wille-Reece, Ulrike Sedegah, Martha Hendriks, Jenny Versteege, Isabella Pau, Maria Grazia Sadoff, Jerold Vanloubbeeck, Yannick Lievens, Marc Heerwegh, Dirk Moris, Philippe Mendoza, Yolanda Guerra Jongert, Erik Cohen, Joe Voss, Gerald Ballou, W. Ripley Vekemans, Johan TI Ad35.CS.01-RTS,S/AS01 Heterologous Prime Boost Vaccine Efficacy against Sporozoite Challenge in Healthy Malaria-Naive Adults SO PLOS ONE LA English DT Article ID PLASMODIUM-FALCIPARUM MALARIA; CIRCUMSPOROZOITE PROTEIN VACCINE; RANDOMIZED CONTROLLED-TRIAL; PHASE 2A TRIAL; MOZAMBICAN CHILDREN; AFRICAN CHILDREN; IMMUNE-RESPONSES; DOUBLE-BLIND; IFN-GAMMA; FOLLOW-UP AB Methods In an observer blind, phase 2 trial, 55 adults were randomized to receive one dose of Ad35. CS. 01 vaccine followed by two doses of RTS,S/AS01 (ARR-group) or three doses of RTS, S/AS01 (RRR-group) at months 0, 1, 2 followed by controlled human malaria infection. Results ARR and RRR vaccine regimens were well tolerated. Efficacy of ARR and RRR groups after controlled human malaria infection was 44% (95% confidence interval 21%-60%) and 52% (25%-70%), respectively. The RRR-group had greater anti-CS specific IgG titers than did the ARR-group. There were higher numbers of CS-specific CD4 T-cells expressing > 2 cytokine/activation markers and more ex vivo IFN-gamma enzyme-linked immunospots in the ARR-group than the RRR-group. Protected subjects had higher CS-specific IgG titers than non-protected subjects (geometric mean titer, 120.8 vs 51.8 EU/ml, respectively; P = .001). Conclusions An increase in vaccine efficacy of ARR-group over RRR-group was not achieved. Future strategies to improve upon RTS, S-induced protection may need to utilize alternative highly immunogenic prime-boost regimens and/or additional target antigens. C1 [Ockenhouse, Christian F.; Regules, Jason; Tosh, Donna; Cowden, Jessica; Kathcart, April; Cummings, James; Paolino, Kristopher; Moon, James; Komisar, Jack; Kamau, Edwin; Oliver, Thomas; Chhoeu, Austin; Murphy, Jitta] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Lyke, Kirsten; Laurens, Matthew] Univ Maryland, Sch Med, Ctr Vaccine Dev, Baltimore, MD 21201 USA. [Birkett, Ashley; Lee, Cynthia; Weltzin, Rich; Wille-Reece, Ulrike] PATH MVI, Washington, DC USA. [Sedegah, Martha] Naval Med Res Ctr, Silver Spring, MD USA. [Hendriks, Jenny; Versteege, Isabella; Pau, Maria Grazia; Sadoff, Jerold] Crucell Holland BV, Leiden, Netherlands. [Vanloubbeeck, Yannick; Lievens, Marc; Heerwegh, Dirk; Moris, Philippe; Mendoza, Yolanda Guerra; Jongert, Erik; Cohen, Joe; Voss, Gerald; Ballou, W. Ripley; Vekemans, Johan] GSK Vaccines, Rixensart, Belgium. RP Ockenhouse, CF (reprint author), Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. EM cockenhouse@path.org RI Moon, James/B-6810-2011; Laurens, Matthew/E-7293-2013 OI Moon, James/0000-0002-9274-4554; Laurens, Matthew/0000-0003-3874-581X FU PATH Malaria Vaccine Initiative (Washington, D.C.); Military Infectious Diseases Research Program (Fort Detrick, MD); DMID [N01-AI05421] FX This work was supported by the PATH Malaria Vaccine Initiative (Washington, D.C.) and the Military Infectious Diseases Research Program (Fort Detrick, MD). The Ad35.CS.01 vaccine was manufactured by Crucell Holland BV., Leiden, The Netherlands, under DMID-supported contract N01-AI05421, NIAID, Bethesda, MD, USA. Crucell Holland BV. provided support in the form of salaries for authors AB, CL, RW, UWR, and contributed to project management, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the 'author contributions' section. NR 41 TC 11 Z9 11 U1 0 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUL 6 PY 2015 VL 10 IS 7 AR e0131571 DI 10.1371/journal.pone.0131571 PG 14 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CN1DQ UT WOS:000358157600109 PM 26148007 ER PT J AU Kalambate, PK Sanghavi, BJ Karna, SP Srivastava, AK AF Kalambate, Pramod K. Sanghavi, Bankim J. Karna, Shashi P. Srivastava, Ashwini K. TI Simultaneous voltammetric determination of paracetamol and domperidone based on a graphene/platinum nanoparticles/nafion composite modified glassy carbon electrode SO SENSORS AND ACTUATORS B-CHEMICAL LA English DT Article DE Paracetamol; Domperidone; Graphene; Platinum nanoparticles; Electrodeposition; Nafion ID POTENTIOMETRIC STRIPPING ANALYSIS; PASTE ELECTRODE; ELECTROCHEMICAL DETERMINATION; COPPER(II) COMPLEX; BIOMIMETIC SENSOR; GRAPHENE OXIDE; FOLIC-ACID; NANOCOMPOSITE; ACETAMINOPHEN; FORMULATIONS AB Graphene oxide and hexachloroplatinic acid were electrochemically reduced on a glassy carbon electrode (GCE) surface so as to form a graphene (Gr)-platinum nanoparticles (PtNP) composite. This nano composite was then coated with nafion (NAF) film so as to form NAF/PtNP/Gr/GCE. In this work, an electrochemical method based on adsorptive stripping square wave voltammetry (AdSSWV) employing NAF/PtNP/Gr/GCE has been proposed for the subnanomolar determination of paracetamol (PCT) and domperidone (DOM) simultaneously. The electrode material was characterized by scanning electron microscopy, energy dispersive X-ray spectroscopy, and X-ray diffraction. The electrochemical performance of PCT and DOM on modified electrode was investigated by cyclic voltammetry, electrochemical impedance spectroscopy, and chronocoulometry. A sixteen fold enhancement in the AdSSWV signal was observed at NAF/PtNP/Gr/GCE in pH 6.0, phosphate buffer, as compared to GCE. Under the optimized conditions, the method allowed simultaneous determination of PCT and DOM in the linear working range of 8.2 x 10(-6)-1.6 x 10(-9) M with detection limits (3 x SD/s) of 1.06 x 10(-10) and 4.37 x 10(-10) M for PCT and DOM respectively. The practical analytical utilities of the modified electrode were demonstrated by the determination of PCT and DOM in pharmaceutical formulations, human urine, and blood serum samples. This proposed method was validated by HPLC and the results are in agreement at the 95% confidence level. Simultaneous voltammetric determination of PCT and DOM has been reported for the first time. (C) 2015 Elsevier B.V. All rights reserved. C1 [Kalambate, Pramod K.; Srivastava, Ashwini K.] Univ Bombay, Dept Chem, Bombay 400098, Maharashtra, India. [Sanghavi, Bankim J.] Univ Virginia, Dept Elect & Comp Engn, Charlottesville, VA 22904 USA. [Karna, Shashi P.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Srivastava, AK (reprint author), Univ Bombay, Dept Chem, Bombay 400098, Maharashtra, India. EM aksrivastava@chem.mu.ac.in FU University Grants Commission, New Delhi, India [UGC/X-PGR23]; US Army International Technology Center, Tokyo, Japan [FA2386-12-1-4086] FX The funding for this work is partly by the University Grants Commission, New Delhi, India, Reference number UGC/X-PGR23 and partly by the US Army International Technology Center, Tokyo, Japan through contract number FA2386-12-1-4086. NR 45 TC 23 Z9 24 U1 15 U2 165 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0925-4005 J9 SENSOR ACTUAT B-CHEM JI Sens. Actuator B-Chem. PD JUL 5 PY 2015 VL 213 BP 285 EP 294 DI 10.1016/j.snb.2015.02.090 PG 10 WC Chemistry, Analytical; Electrochemistry; Instruments & Instrumentation SC Chemistry; Electrochemistry; Instruments & Instrumentation GA CE9GQ UT WOS:000352152500038 ER PT J AU Karim, MA Schroeder, PR Bunch, BW AF Karim, M. A. Schroeder, P. R. Bunch, B. W. TI A Preliminary Laboratory Investigation of PCB Flux from Dredge Resuspensions and Residuals SO SOIL & SEDIMENT CONTAMINATION LA English DT Article DE dredging; laboratory investigation; residuals; resuspension; Sediment contamination; PCB AB A preliminary laboratory investigation was conducted to understand the relative contributions of major dredge resuspension and residual processes on the releases of polychlorinated biphenyl (PCB) contaminants from sediments to water column. Sediments from New Bedford Harbor were used as test samples. Six sets of experiments were run for simulated resuspension and residual scenarios. During the experiments, water above the sediments was recirculated by peristaltic pumping or orbital shaking and the levels of two PCBs, Aroclor 1248 (PCB-1248) and Aroclor 1254 (PCB-1254), were monitored for 15days. Analysis of the model predicted data indicated that resulting water column PCB concentrations differed with sediment surface, residual, and resuspension type. Highest PCB water column concentrations were observed for a condition which used a settled fluff from thin sediment slurry as a residual source and the column water was recirculated by orbital shaking. Lowest water column PCB levels were observed for a thick sediment deposit placed over clean sand. The PCB levels in the water column for all six simulated conditions were several orders higher than the USEPA ambient water quality criteria concentrations for aquatic environment and human consumption. C1 [Karim, M. A.] Kennesaw State Univ, Dept Civil & Construct Engn, Marietta, GA 30060 USA. [Schroeder, P. R.; Bunch, B. W.] US Army, Corps Engineers, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Karim, MA (reprint author), Kennesaw State Univ, Dept Civil & Construct Engn, 1100 South Marietta Pkwy,M-162B,Marietta Campus, Marietta, GA 30060 USA. EM mkarim4@kennesaw.edu FU Environmental Laboratory, U.S. Army Corps of Engineers, under U.S. Army Research Office Scientific Services Program [0139, W911NF-11-D-0001] FX This work was supported by the Environmental Laboratory, U.S. Army Corps of Engineers, under the auspices of the U.S. Army Research Office Scientific Services Program administered by Battelle (Delivery Order 0139, Contract No. W911NF-11-D-0001). NR 11 TC 2 Z9 2 U1 1 U2 8 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1532-0383 EI 1549-7887 J9 SOIL SEDIMENT CONTAM JI Soil. Sediment. Contam. PD JUL 4 PY 2015 VL 24 IS 5 BP 526 EP 541 DI 10.1080/15320383.2015.986263 PG 16 WC Environmental Sciences SC Environmental Sciences & Ecology GA CJ9DV UT WOS:000355803600004 ER PT J AU Shurtleff, AC Bavari, S AF Shurtleff, Amy C. Bavari, Sina TI Animal models for ebolavirus countermeasures discovery: what defines a useful model? SO EXPERT OPINION ON DRUG DISCOVERY LA English DT Review DE African green; animal model; antiviral; countermeasure; cynomolgus; ebolavirus; FDA animal efficacy rule; filoviruses; guinea pig; hamster; hemorrhagic fever; in vivo; macaque; marmoset; mice; nonhuman primate; pig; rhesus; therapeutics; vaccine ID FILOVIRUS MEDICAL COUNTERMEASURES; HEMORRHAGIC-FEVER VIRUS; NONHUMAN PRIMATE MODEL; AFRICAN-GREEN MONKEYS; GUINEA-PIGS; RHESUS MACAQUES; ZAIRE-EBOLAVIRUS; IMMUNE-RESPONSES; DENDRITIC CELLS; MOUSE MODEL AB Introduction: Ebolaviruses are highly pathogenic filoviruses, which cause disease in humans and nonhuman primates (NHP) in Africa. The Zaire ebolavirus outbreak in 2014, which continues to greatly affect Western Africa and other countries to which the hemorrhagic fever was exported due to travel of unsymptomatic yet infected individuals, was complicated by the lack of available licensed vaccines or therapeutics to combat infection. After almost a year of research at an increased pace to find and test vaccines and therapeutics, there is now a deeper understanding of the available disease models for ebolavirus infection. Demonstration of vaccine or therapeutic efficacy in NHP models of ebolavirus infection is crucial to the development and eventual licensure of ebolavirus medical countermeasures, so that safe and effective countermeasures can be accelerated into human clinical trials.Areas covered: The authors describe ebolavirus hemorrhagic fever (EHF) disease in various animal species: mice, guinea pigs, hamsters, pigs and NHP, to include baboons, marmosets, rhesus and cynomolgus macaques, as well as African green monkeys. Because the NHP models are supremely useful for therapeutics and vaccine testing, emphasis is placed on comparison of these models, and their use as gold-standard models of EHF.Expert opinion: Animal models of EHF varying from rodents to NHP species are currently under evaluation for their reproducibility and utility for modeling infection in humans. Complete development and licensure of therapeutic agents and vaccines will require demonstration that mechanisms conferring protection in NHP models of infection are predictive of protective responses in humans, for a given countermeasure. C1 [Shurtleff, Amy C.; Bavari, Sina] US Army Med Res Inst Infect Dis, Div Mol & Translat Sci, 1425 Porter St, Frederick, MD 21702 USA. RP Bavari, S (reprint author), US Army Med Res Inst Infect Dis, Div Mol & Translat Sci, 1425 Porter St, Frederick, MD 21702 USA. EM sina.bavari@us.army.mil FU US Defense Threat Reduction Agency; Medical Countermeasures Systems FX The authors are supported by the US Defense Threat Reduction Agency and by Medical Countermeasures Systems. The opinions, interpretations, conclusions and recommendations are those of the authors and are not necessarily endorsed by the US Army. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. NR 137 TC 4 Z9 4 U1 0 U2 3 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1746-0441 EI 1746-045X J9 EXPERT OPIN DRUG DIS JI Expert. Opin. Drug Discov. PD JUL 3 PY 2015 VL 10 IS 7 BP 685 EP 702 DI 10.1517/17460441.2015.1035252 PG 18 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA DC7LK UT WOS:000369401300001 PM 26004783 ER PT J AU Fenton, E Chillag, K Michael, NL AF Fenton, Elizabeth Chillag, Kata Michael, Nelson L. TI Ethics Preparedness for Public Health Emergencies: Recommendations From the Presidential Bioethics Commission SO AMERICAN JOURNAL OF BIOETHICS LA English DT Letter ID POLITICS; EBOLA C1 [Fenton, Elizabeth; Chillag, Kata] Presidential Commiss Study Bioeth Issues, Washington, DC 20005 USA. [Michael, Nelson L.] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Fenton, E (reprint author), Presidential Commiss Study Bioeth Issues, 1425 New York Ave NW, Washington, DC 20005 USA. EM Elizabeth.Fenton@bioethics.gov NR 5 TC 0 Z9 1 U1 0 U2 3 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 1526-5161 EI 1536-0075 J9 AM J BIOETHICS JI Am. J. Bioeth. PD JUL 3 PY 2015 VL 15 IS 7 BP 77 EP 79 DI 10.1080/15265161.2015.1054162 PG 3 WC Ethics; Medical Ethics; Social Issues; Social Sciences, Biomedical SC Social Sciences - Other Topics; Medical Ethics; Social Issues; Biomedical Social Sciences GA CM2CO UT WOS:000357487600029 PM 26147281 ER PT J AU Hu, YJ Li, J Darling, KA Wang, WY VanLeeuwen, BK Liu, XL Kecskes, LJ Dickey, EC Liu, ZK AF Hu, Yong-Jie Li, Jing Darling, Kristopher A. Wang, William Y. VanLeeuwen, Brian K. Liu, Xuan L. Kecskes, Laszlo J. Dickey, Elizabeth C. Liu, Zi-Kui TI Nano-sized Superlattice Clusters Created by Oxygen Ordering in Mechanically Alloyed Fe Alloys SO SCIENTIFIC REPORTS LA English DT Article ID NANOCRYSTALLINE IRON; THERMAL-STABILITY; FERRITIC ALLOYS; GRAIN-SIZE; ZR ALLOYS; CR ALLOYS; TEMPERATURE; PARTICLES; STEEL; AL AB Creating and maintaining precipitates coherent with the host matrix, under service conditions is one of the most effective approaches for successful development of alloys for high temperature applications; prominent examples include Ni- and Co-based superalloys and Al alloys. While ferritic alloys are among the most important structural engineering alloys in our society, no reliable coherent precipitates stable at high temperatures have been found for these alloys. Here we report discovery of a new, nano-sized superlattice (NSS) phase in ball-milled Fe alloys, which maintains coherency with the BCC matrix up to at least 913 degrees C. Different from other precipitates in ferritic alloys, this NSS phase is created by oxygen-ordering in the BCC Fe matrix. It is proposed that this phase has a chemistry of Fe3O and a Do(3) crystal structure and becomes more stable with the addition of Zr. These nano-sized coherent precipitates effectively double the strength of the BCC matrix above that provided by grain size reduction alone. This discovery provides a new opportunity for developing high-strength ferritic alloys for high temperature applications. C1 [Hu, Yong-Jie; Wang, William Y.; VanLeeuwen, Brian K.; Liu, Xuan L.; Liu, Zi-Kui] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. [Li, Jing; Dickey, Elizabeth C.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Darling, Kristopher A.; Kecskes, Laszlo J.] US Army Res Lab, Weap & Mat Res Directorate, RDRL WMM F, Aberdeen Proving Ground, MD 21005 USA. RP Hu, YJ (reprint author), Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. EM yoh5120@psu.edu RI Wang, William Yi/F-8212-2011; Dickey, Elizabeth/A-3368-2011; Liu, Zi-Kui/A-8196-2009 OI Wang, William Yi/0000-0002-8814-525X; Dickey, Elizabeth/0000-0003-4005-7872; Liu, Zi-Kui/0000-0003-3346-3696 NR 52 TC 0 Z9 0 U1 6 U2 30 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD JUL 2 PY 2015 VL 5 AR 11772 DI 10.1038/srep11772 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CL9AZ UT WOS:000357267600001 PM 26134420 ER PT J AU Franz, DR AF Franz, David R. TI IMPLEMENTING THE SELECT AGENT LEGISLATION: PERFECT RECORD OR WRONG METRIC? SO HEALTH SECURITY LA English DT Editorial Material C1 [Franz, David R.] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. EM davidrfranz@gmail.com NR 11 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 2326-5094 EI 2326-5108 J9 HEALTH SECUR JI Health Secur. PD JUL-AUG PY 2015 VL 13 IS 4 BP 290 EP 294 DI 10.1089/hs.2015.0029 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA DD4QR UT WOS:000369908100006 PM 26230907 ER PT J AU Littlefield, PD Tolisano, AM Sabol, JV Herberg, ME Coppit, GL AF Littlefield, Philip D. Tolisano, Anthony M. Sabol, Jennifer V. Herberg, Matthew E. Coppit, George L., III TI Total Auricular Rehabilitation: Combined Cosmetic and Functional Lateral Temporal Bone Reconstruction SO JOURNAL OF CRANIOFACIAL SURGERY LA English DT Article DE Prostheses and implants; temporal bone/pathology; temporal bone/surgery ID ANCHORED HEARING-AID; ANTEROLATERAL THIGH FLAP; FREE TISSUE TRANSFER; ILIAC CREST; NECK DEFECTS; FOLLOW-UP; IMPLANT; EXPERIENCE; HEAD; COMPLICATIONS AB Objective: The aim of the study was to describe 3 cases of total auricular rehabilitation, including the novel use of iliac crest bone grafts to support bone-anchored auricular prostheses. Study Design: This study is a retrospective case series from a single institution. Results: Three cases with large lateral temporal bone and soft tissue defects were successfully treated with total auricular rehabilitation. Rehabilitation included the following: soft tissue coverage with an anterolateral thigh microvascular free flap, iliac crest-free bone graft with staged placement of a bone-anchored auricular prosthesis into the bone graft, and audiologic rehabilitation with a bone-anchored hearing aid (BAHA). All of the cases with grafts and flaps survived and were without significant donor site morbidity. Bone-anchored hearing aid abutment skin overgrowth was seen in 2 cases and was revised under local anesthesia. All of the patients had expected functional recovery on postoperative audiologic testing. Each patient continues to consistently wear his/her auricular prosthesis and BAHA during 3 years of follow-up. Conclusions: Total auricular rehabilitation is a complex task involving reconstruction of extensive soft tissue defects, bony defects, and the hearing apparatus. Acceptable cosmetic and functional outcomes and high patient satisfaction is possible in committed patients. C1 [Littlefield, Philip D.; Tolisano, Anthony M.] Tripler Army Med Ctr, Dept Otolaryngol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. [Littlefield, Philip D.; Herberg, Matthew E.; Coppit, George L., III] Walter Reed Natl Mil Med Ctr, Dept Otolaryngol, Bethesda, MD USA. [Sabol, Jennifer V.] Walter Reed Natl Mil Med Ctr, Dept Maxillofacial Prosthet, Bethesda, MD USA. RP Tolisano, AM (reprint author), Tripler Army Med Ctr, Dept Otolaryngol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM anthony.m.tolisano.mil@mail.mil NR 39 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1049-2275 EI 1536-3732 J9 J CRANIOFAC SURG JI J. Craniofac. Surg. PD JUL PY 2015 VL 26 IS 5 BP 1467 EP 1470 DI 10.1097/SCS.0000000000001770 PG 4 WC Surgery SC Surgery GA DD0LH UT WOS:000369611000049 PM 26114506 ER PT J AU Madrid, PB Panchal, RG Warren, TK Shurtleff, AC Endsley, AN Green, CE Kolokoltsov, A Davey, R Manger, ID Gilfillan, L Bavari, S Tanga, MJ AF Madrid, Peter B. Panchal, Raba G. Warren, Travis K. Shurtleff, Amy C. Endsley, Aaron N. Green, Carol E. Kolokoltsov, Andrey Davey, Robert Manger, Ian D. Gilfillan, Lynne Bavari, Sina Tanga, Mary J. TI Evaluation of Ebola Virus Inhibitors for Drug Repurposing SO ACS INFECTIOUS DISEASES LA English DT Article DE Ebola; viral inhibition; cellular toxicity; chloroquine; drug repurposing ID CLINICAL-IMPLICATIONS; HEMORRHAGIC-FEVER; VIRAL-INFECTIONS; PHARMACOKINETICS; CHLOROQUINE; ENTRY; HYDROXYCHLOROQUINE; NICLOSAMIDE; AMODIAQUINE; VOLUNTEERS AB A systematic screen of FDA-approved drugs was performed to identify compounds with in vitro antiviral activities against Ebola virus (EBOV). Compounds active (>50% viral inhibition and <30% cellular toxicity) at a single concentration were tested in dose response assays to quantitate the antiviral activities in replication and viral entry assays as well as cytotoxicity in the Vero cell line used to conduct these assays. On the basis of the approved human dosing, toxicity/tolerability, and pharmacokinetic data, seven of these in vitro hits from different pharmacological classes (chloroquine (CQ), amiodarone, prochlorperazine, benztropine, azithromycin, chlortetracycline, and clomiphene) were evaluated for their in vivo efficacy at a single dose and were administered via either intraperitoneal (ip) or oral route. Initially, azithromycin (100 mg/kg, twice daily, ip), CQ (90 mg/kg, twice daily, ip), and amiodarone (60 mg/kg, twice daily, ip) demonstrated significant increases in survival in the mouse model. After repeat evaluation, only CQ was found to reproducibly give significant efficacy in the mouse model with this dosing regimen. Azithromycin and CQ were also tested in a guinea pig model of EBOV infection over a range of doses, but none of the doses increased survival, and drug-related toxicity was observed at lower doses than in the mouse. These results show the benefits and specific challenges associated with drug repurposing and highlight the need for careful evaluation of approved drugs as rapidly deployable countermeasures against future pandemics. C1 [Madrid, Peter B.; Endsley, Aaron N.; Green, Carol E.; Manger, Ian D.; Gilfillan, Lynne; Tanga, Mary J.] SRI Int, Biosci Div, 333 Ravenswood Ave, Menlo Pk, CA 94025 USA. [Panchal, Raba G.; Warren, Travis K.; Shurtleff, Amy C.; Bavari, Sina] US Army Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Kolokoltsov, Andrey; Davey, Robert] Univ Texas Med Branch, Galveston, TX 77555 USA. RP Madrid, PB (reprint author), SRI Int, Biosci Div, 333 Ravenswood Ave, Menlo Pk, CA 94025 USA. EM peter.madrid@sri.com FU SRI International; Defense Threat Reduction Agency (DTRA) TMTI [HDTRA1-07-C-0083] FX This work was funded by internal grants of SRI International and the Defense Threat Reduction Agency (DTRA) TMTI Grant HDTRA1-07-C-0083. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We thank Jay Wells, Sean Vantongeren, and Kelly Stuthman for execution of the in vivo studies and other project team members, Rae Lyn Burke, Tiffany R. Keepers, Lalitha V. Iyer, Ricardo Carrion Jr., and Jean L. Patterson, for their valuable contributions to the overall DTRA drug-repurposing project. Opinions, interpretations, conclusions, and recommendations stated within the paper are those of the authors and are not necessarily endorsed by the U.S. Army nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. government. NR 25 TC 0 Z9 0 U1 1 U2 7 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 2373-8227 J9 ACS INFECT DIS JI ACS Infect. Dis. PD JUL PY 2015 VL 1 IS 7 BP 317 EP 326 DI 10.1021/acsinfecdis.5b00030 PG 10 WC Chemistry, Medicinal; Infectious Diseases SC Pharmacology & Pharmacy; Infectious Diseases GA DB4DM UT WOS:000368463700005 PM 27622822 ER PT J AU Netherland, MD AF Netherland, Michael D. TI Laboratory and greenhouse response of monoecious hydrilla to fluridone SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article DE aquatic herbicide; aquatic plant management; PAM fluorometer; photosynthesis; submersed invasive plant ID DIOECIOUS HYDRILLA; EURASIAN WATERMILFOIL; VERTICILLATA; TEMPERATURE; BIOTYPES; TURIONS; GROWTH; PHOTOPERIODS; EXPOSURES; TUBERS AB Spread of the monoecious biotype of hydrilla (Hydra la verticillata L.f. Royle) into natural lakes and streams of northern-tier states is of concern to resource managers. In response, multiple eradication programs relying on fluridone have been initiated. Although fluridone controls monoecious hydrilla, limited quantitative information exists on effective concentrations and exposures. I conducted growth-chamber and mesocosm studies to determine sensitivity of hydrilla to various concentrations and exposures of fluridone. Sprouted hydrilla tubers were exposed to fluridone at concentrations ranging from 1.5 to 48 mu g L-1 and chlorophyll fluorescence yield of apical shoots measured via a pulse amplitude-modulated fluorometer was reduced by over 85% at fluridone concentrations > 3 mu g L-1 Hthe response of established hydrilla to fluridone at concentrations of 3 to 48 mu g L-1. Although chorophyll fluorescence yield of apical shoots from established plants was similar to that observed in the lab tydrilla was also exposed to fluridone for intermittent periods and compared with plants that received continuous fluridone exposures. Removal of treated plants from fluridone for periods of 3 and 6 d followed by placing plants back in fluridone-treated water produced similar results through a 35-d period. Data confirm that a significant lag period exists between removal from fluridone exposure and recovery of photosynthetic pigments. I evaluated the response of sprouting tubers in greenhouse trials to fluridone at 1.5 to 12 mu g L-1. Fluridone at 6 and 12 mu g L-1 prevented hydrilla from emerging, whereas concentrations of 1.5 and 3 mu g L-1 reduced biomass by 84 to 96%. I also evaluated rials, the reduction in biomass was much slower over a 70-d period and was concentration dependent. Monoecious hydrilla is highly sensitive to fluridone and results suggest that control can be achieved via maintenance of low fluridone concentrations. Application of fluridone early in the growing season before shoot emergence or before accumulation of significant biomass is recommended to reduce overall exposure requirements. C1 [Netherland, Michael D.] US Army Engn Res & Dev Ctr, Gainesville, FL 32653 USA. RP Netherland, MD (reprint author), US Army Engn Res & Dev Ctr, 7922 NW 71st St, Gainesville, FL 32653 USA. EM Michael.D.Netherland@usace.army.mil FU Great Lakes Restoration Initiative through the U.S. Army Corps of Engineers Buffalo District; U.S. Army Engineer Research and Development Center, Aquatic Plant Control Research Program FX Funding for this project was provided by Great Lakes Restoration Initiative through the U.S. Army Corps of Engineers Buffalo District and the U.S. Army Engineer Research and Development Center, Aquatic Plant Control Research Program. The assistance of Erin Canter with data collection is greatly appreciated. Citation of trade names does not constitute endorsement or approval of the use of such commercial products. Permission to publish this paper was granted by the Chief of Engineers. NR 37 TC 1 Z9 1 U1 2 U2 6 PU AQUATIC PLANT MANAGEMENT SOC, INC PI VICKSBURG PA PO BOX 821265, VICKSBURG, MS 39182 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JUL PY 2015 VL 53 BP 178 EP 184 PG 7 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA DA7DO UT WOS:000367965000005 ER PT J AU Willey, LN Netherland, MD AF Willey, Leif N. Netherland, Michael D. TI Influence of sediment coverage on sprouting of crested floating-heart ramets and response of quiescent ramets to contact herbicides SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article C1 [Willey, Leif N.] Aquat Syst Inc, Pompano Beach, FL 33069 USA. US Army Engn Res & Dev Ctr, Ctr Aquat & Invas Plants, Gainesville, FL 32653 USA. RP Willey, LN (reprint author), Aquat Syst Inc, 2100 NW 33rd St, Pompano Beach, FL 33069 USA. EM leif.willey@aquaticsystems.com FU Florida Fish and Wildlife Commission, Invasive Plant Management Section FX Funding for this project was provided by the Florida Fish and Wildlife Commission, Invasive Plant Management Section. We also thank G. Hoyer and Z. Banks for assisting with data collection and maintaining plant stocks. Permission was granted by the Chief of Engineers to publish this information. Citation of trade names does not constitute endorsement or approval of the use of such commercial products. NR 10 TC 0 Z9 0 U1 0 U2 0 PU AQUATIC PLANT MANAGEMENT SOC, INC PI VICKSBURG PA PO BOX 821265, VICKSBURG, MS 39182 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JUL PY 2015 VL 53 BP 216 EP 219 PG 4 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA DA7DO UT WOS:000367965000011 ER PT J AU Pang, CK Hudas, GR Middleton, MB Le, CV Lewis, FL AF Pang, Chee Khiang Hudas, Greg R. Middleton, Matthew B. Le, Cao Vinh Lewis, Frank L. TI Discrete event command and control for network teams with multiple military missions SO JOURNAL OF DEFENSE MODELING AND SIMULATION-APPLICATIONS METHODOLOGY TECHNOLOGY-JDMS LA English DT Article DE discrete event control; military battlefield command and control; mission execution and resource assignment; rule-based control ID SYSTEM; DESIGN AB During mission execution in military applications, the US Army Training and Doctrine Command Pamphlet 525-66 Battle Command and Battle Space Awareness capabilities prescribe expectations that networked teams will perform in a reliable manner under changing mission requirements, varying resource availability and reliability, resource faults, etc. In this paper, a command and control structure is presented that allows for computer-aided execution of the networked team decision-making process, control of force resources, shared-resource dispatching, and adaptability to change based on battlefield conditions. A mathematically justified networked computing environment is provided called the Discrete Event Control (DEC) framework. DEC has the ability to provide the logical connectivity among all team participants, including mission planners, field commanders, warfighters, and robotic platforms. The proposed data management tools are developed and demonstrated with a simulation study on a realistic military ambush attack. The results show that the tasks of multiple missions are correctly sequenced in real time, and that shared resources are suitably assigned to competing tasks under dynamically changing conditions without conflicts and bottlenecks. C1 [Pang, Chee Khiang; Le, Cao Vinh] Natl Univ Singapore, Dept Elect & Comp Engn, Singapore 117583, Singapore. [Hudas, Greg R.] US Army, RDECOM TARDEC, JCR, Washington, DC USA. [Middleton, Matthew B.; Lewis, Frank L.] Univ Texas Arlington, UT Arlington Res Inst, Arlington, TX USA. RP Pang, CK (reprint author), Natl Univ Singapore, Fac Engn, Dept Elect & Comp Engn, Block E4 05-33,4 Engn Dr 3, Singapore 117583, Singapore. EM justinpang@nus.edu.sg NR 25 TC 1 Z9 1 U1 3 U2 4 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1548-5129 EI 1557-380X J9 J DEF MODEL SIMUL-AP JI J. Def. Model. Simul.-Appl. Methodol. Technol.-JDMS PD JUL PY 2015 VL 12 IS 3 BP 241 EP 255 DI 10.1177/1548512912472772 PG 15 WC Engineering, Multidisciplinary SC Engineering GA DA1IT UT WOS:000367550200004 ER PT J AU Richardson, GP Black, LJ Deegan, M Ghaffarzadegan, N Greer, D Kim, H Luna-Reyes, LF MacDonald, R Rich, E Stave, KA Zimmermann, N Andersen, DF AF Richardson, George P. Black, Laura J. Deegan, Michael Ghaffarzadegan, Navid Greer, Donald Kim, Hyunjung Luna-Reyes, Luis F. MacDonald, Roderick Rich, Eliot Stave, Krystyna A. Zimmermann, Nicole Andersen, David F. TI Reflections on peer mentoring for ongoing professional development in system dynamics SO SYSTEM DYNAMICS REVIEW LA English DT Article C1 [Richardson, George P.; Luna-Reyes, Luis F.; Rich, Eliot; Andersen, David F.] SUNY Albany, Albany, NY 12222 USA. [Black, Laura J.] Montana State Univ, Bozeman, MT 59717 USA. [Deegan, Michael] US Army Corps Engineers, Washington, DC USA. [Ghaffarzadegan, Navid] Virginia Tech, Blacksburg, VA 24061 USA. [Greer, Donald] Greer Black Co, Bozeman, MT 69715 USA. [Kim, Hyunjung] Calif State Univ Chico, Chico, CA 95929 USA. [MacDonald, Roderick] SUNY Albany, Initiat Syst Dynam, Publ Sect, Albany, NY 12222 USA. [Stave, Krystyna A.] Univ Nevada, Las Vegas, NV 89154 USA. [Zimmermann, Nicole] UCL, London WC1E 6BT, England. RP Kim, H (reprint author), Calif State Univ Chico, Dept Mangagement, Chico, CA 95929 USA. EM hkim18@csuchico.edu RI Luna-Reyes, Luis/G-5548-2012 OI Luna-Reyes, Luis/0000-0002-0852-404X NR 2 TC 1 Z9 1 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0883-7066 EI 1099-1727 J9 SYST DYNAM REV JI Syst. Dyn. Rev. PD JUL-SEP PY 2015 VL 31 IS 3 BP 173 EP 181 DI 10.1002/sdr.1542 PG 9 WC Management; Social Sciences, Mathematical Methods SC Business & Economics; Mathematical Methods In Social Sciences GA CZ6RK UT WOS:000367228200004 ER PT J AU Nicely, NI Wiehe, K Kepler, TB Jaeger, FH Dennison, SM Rerks-Ngarm, S Nitayaphan, S Pitisuttithum, P Kaewkungwal, J Robb, ML O'Connell, RJ Michael, NL Kim, JH Liao, HX Alam, SM Hwang, KK Bonsignori, M Haynes, BF AF Nicely, Nathan I. Wiehe, Kevin Kepler, Thomas B. Jaeger, Frederick H. Dennison, S. Moses Rerks-Ngarm, Supachai Nitayaphan, Sorachai Pitisuttithum, Punnee Kaewkungwal, Jaranit Robb, Merlin L. O'Connell, Robert J. Michael, Nelson L. Kim, Jerome H. Liao, Hua-Xin Alam, S. Munir Hwang, Kwan-Ki Bonsignori, Mattia Haynes, Barton F. TI Structural analysis of the unmutated ancestor of the HIV-1 envelope V2 region antibody CH58 isolated from an RV144 vaccine efficacy trial vaccinee SO EBIOMEDICINE LA English DT Article DE HIV-1; Gp120; V2; RV-144; Antibody maturation; Germline; Unmutated ancestor ID NEUTRALIZING ANTIBODIES; AFFINITY MATURATION; INTEGRIN ALPHA(4)BETA(7); MONOCLONAL-ANTIBODIES; CRYSTAL-STRUCTURE; IMMUNE-RESPONSE; RECOGNITION; BINDING; BROAD; FLEXIBILITY AB Human monoclonal antibody CH58 isolated from an RV144 vaccinee binds at Lys169 of the HIV-1 Env gp120 V2 region, a site of vaccine-induced immune pressure. CH58 neutralizes HIV-1 CRF_ 01 AE strain 92TH023 and mediates ADCC against CD4+T cell targets infected with CRF_ 01 AE tier 2 virus. CH58 and other antibodies that bind to a gp120 V2 epitope have a second light chain complementarity determining region (LCDR2) bearing a glutamic acid, aspartic acid (ED) motif involved in forming salt bridges with polar, basic side amino acid side chains in V2. In an effort to learn how V2 responses develop, we determined the crystal structures of the CH58-UA antibody unliganded and bound to V2 peptide. The structures showed an LCDR2 structurally preconformed from germline to interact with V2 residue Lys169. LCDR3 was subject to conformational selection through the affinity maturation process. Kinetic analyses demonstrate that only a few contacts were responsible for a 2000-fold increase in KD through maturation, and this effect was predominantly due to an improvement in off-rate. This study shows that preconformation and preconfiguration can work in concert to produce antibodies with desired immunogenic properties. (C) 2015 The Authors. Published by Elsevier B. V. C1 [Nicely, Nathan I.; Wiehe, Kevin; Jaeger, Frederick H.; Dennison, S. Moses; Liao, Hua-Xin; Alam, S. Munir; Hwang, Kwan-Ki; Bonsignori, Mattia; Haynes, Barton F.] Duke Univ, Sch Med, Duke Human Vaccine Inst, Durham, NC 27708 USA. [Kepler, Thomas B.] Boston Univ, Dept Microbiol, Boston, MA 02215 USA. [Rerks-Ngarm, Supachai] Minist Publ Hlth, Nonthaburi, Thailand. [Nitayaphan, Sorachai; O'Connell, Robert J.] Armed Forces Res Inst Med Sci, Bangkok, Thailand. [Pitisuttithum, Punnee; Kaewkungwal, Jaranit] Mahidol Univ, Bangkok 10700, Thailand. [Robb, Merlin L.] US Mil HIV Res Program, Henry Jackson Fdn HIV Program, Bethesda, MD USA. [Michael, Nelson L.; Kim, Jerome H.] Walter Reed Army Inst Res, US Mil HIV Res Program MHRP, Silver Spring, MD USA. RP Nicely, NI (reprint author), Duke Univ, Sch Med, Duke Human Vaccine Inst, Durham, NC 27708 USA. EM nathan.nicely@duke.edu; hayne002@mc.duke.edu NR 50 TC 4 Z9 4 U1 0 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 2352-3964 J9 EBIOMEDICINE JI EBioMedicine PD JUL PY 2015 VL 2 IS 7 BP 713 EP 722 DI 10.1016/j.ebiom.2015.06.016 PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA CX8LB UT WOS:000365953900024 PM 26288844 ER PT J AU Riaz, M Certal, V Camacho, M AF Riaz, M. Certal, V. Camacho, M. TI Portable power supply options for positive airway pressure devices SO RURAL AND REMOTE HEALTH LA English DT Article DE CPAP battery; PAP backup power; PAP power options; portable CPAP; sleep apnea and power outages; sleep apnea travelers; sleep apnea travelers to remote areas; wilderness and sleep apnea ID OBSTRUCTIVE SLEEP-APNEA; RANDOMIZED CONTROLLED-TRIAL; STROKE; ASSOCIATION; ADHERENCE; THERAPY; DISEASE; ADULTS; DEATH AB Introduction: Patients with obstructive sleep apnea (OSA) often face the challenge of how to power their positive airway pressure (PAP) devices when alternating current power supplies are not available in remote areas with lack of electricity or frequent power outages. This article elucidates portable power supply options for PAP devices with the aim to increase alternative power source awareness among medical providers. Methods: A search of scientific databases (Medline, Scopus, Web of Science, Google Scholar, and the Cochrane Library) was carried out on the topic of alternative portable power supply options for treatment of OSA. Results: Scientific databases listed above yielded only limited results. Most articles were found via Google search. These articles were reviewed for alternative power supply options for OSA patients when alternating current is not available. The power supply options in this article include lead-acid batteries (starter, marine and deep-cycle batteries), lithium ion batteries, solar kits, battery packs, backup power systems, portable generators, and travel-size PAP devices. Conclusions: There are several options to power PAP devices with direct current when alternating current is not available. Knowledgeable primary care physicians especially in rural and remote areas can help OSA patients improve PAP compliance in order to mitigate morbidity and long-term complications of OSA. C1 [Riaz, M.] Univ Michigan, Ann Arbor, MI 48109 USA. [Certal, V.] Hosp CUF, Sleep Med Ctr, Dept Otorhinolaryngol, Oporto, Portugal. [Camacho, M.] Tripler Army Med Ctr, Dept Sleep Med & Otolaryngol Head & Neck Surg, Honolulu, HI 96859 USA. RP Riaz, M (reprint author), Univ Michigan, Ann Arbor, MI 48109 USA. RI FMUP, CINTESIS/C-6631-2014; OI FMUP, CINTESIS/0000-0001-7248-2086; Riaz, Muhammad/0000-0001-9512-3334; Camacho, Macario/0000-0001-9200-9085 NR 37 TC 0 Z9 0 U1 0 U2 4 PU AUSTRALIAN RURAL HEALTH EDUC NETWORK PI DEAKIN WEST PA PO BOX 242, DEAKIN WEST, ACT 2600, AUSTRALIA SN 1445-6354 J9 RURAL REMOTE HEALTH JI Rural Remote Health PD JUL-SEP PY 2015 VL 15 IS 3 AR 3499 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CX3LZ UT WOS:000365601800041 PM 26220154 ER PT J AU Harris, JT Segall, AE Robinson, D Carter, R AF Harris, J. T. Segall, A. E. Robinson, D. Carter, R. TI Cohesive Zone Property Measurement by a Hybrid Experimental and Numerical Method Using Ball Indentations SO JOURNAL OF TESTING AND EVALUATION LA English DT Article DE cohesive zone; ball indentation; FEA; fracture energy; bond strength ID THIN POLYMER-COATINGS; DUCTILE SUBSTRATE; ADHESIVE JOINTS; STRONG FILM; FRACTURE; DELAMINATION; INTERFACES; STRENGTH; MODELS AB Although there are several techniques available for the evaluation of various interfacial cohesive zone properties of coatings, each has difficulties and limitations. For instance, the four-point bend method is often plagued by excessive deformation and plasticity without any coating delamination, and the button test is limited by the constant stress distribution assumption. Given such issues, a new hybrid numerical/experimental technique has been developed that is based on ball indentations, which can usually induce delamination regardless of the materials used. Using this method, indentations were first made on coated samples (nickel-on-steel and aluminum-on-aluminum for the current study) to intentionally create localized, circular delaminations, the initiation and dimensions of which were functions of the applied loads. Numerical models using finite element analysis were then used with the known indentation loads to inversely evaluate the cohesive zone properties, which reproduced the experimental results. The technique was validated based on the successful prediction of the indentation results evaluated using properties from four-point bend results. C1 [Harris, J. T.; Segall, A. E.; Robinson, D.] Penn State Univ, Engn Sci & Mech, University Pk, PA 16803 USA. [Carter, R.] US Army Res Lab, AMSRL WM MB, Aberdeen Proving Ground, MD 21005 USA. RP Segall, AE (reprint author), Penn State Univ, Engn Sci & Mech, University Pk, PA 16803 USA. EM aesegall@psu.edu; rcarter@arl.army.mil NR 25 TC 0 Z9 0 U1 2 U2 3 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 USA SN 0090-3973 EI 1945-7553 J9 J TEST EVAL JI J. Test. Eval. PD JUL PY 2015 VL 43 IS 4 BP 765 EP 775 DI 10.1520/JTE20130102 PG 11 WC Materials Science, Characterization & Testing SC Materials Science GA CV1XG UT WOS:000364050800004 ER PT J AU Wehmeyer, JL Natesan, S Christy, RJ AF Wehmeyer, Jennifer L. Natesan, Shanmugasundaram Christy, Robert J. TI Development of a Sterile Amniotic Membrane Tissue Graft Using Supercritical Carbon Dioxide SO TISSUE ENGINEERING PART C-METHODS LA English DT Article ID HUMAN FETAL MEMBRANES; LIMBAL EPITHELIAL-CELLS; SURFACE RECONSTRUCTION; DONOR SKIN; TRANSPLANTATION; COLLAGEN; STERILIZATION; IDENTIFICATION; PROTEINS; MATRIX AB Numerous techniques have been reported for preparing and sterilizing amniotic membrane (AM) for use in clinical applications. However, these preparations either do not produce completely sterile tissue or are detrimental to molecules unique to the tissue matrix, thus compromising beneficial wound-healing properties of the AM graft. The objective of this work was to produce a sterile human AM tissue graft using a novel preparation technique involving supercritical carbon dioxide (SCCO2). AM tissue was subjected to various sterilization treatment groups that optimized the duration of exposure to SCCO2 and the amount of peracetic acid (PAA) required to achieve a sterility assurance level of 10(-6) log reduction in bacterial load. Effects of sterilization treatment on the histological, biophysical, and biochemical properties of the sterile AM were evaluated and compared with those of native AM tissue. Exposure of the AM tissue to combined SCCO2 and PAA sterilization treatment did not significantly alter tissue architecture, the amounts of pertinent extracellular matrix proteins (type IV collagen, glycosaminoglycans, elastin) present in the tissue, or the biophysical properties of the tissue. AMs treated with SCCO2 were also found to be excellent substrates for adipose-derived stem cell (ASC) attachment and proliferation in vitro. Human ASCs, attached to all treatment groups after 24h of culture and continued to proliferate over the next few days. The current study's results indicate that SCCO2 can be used to sterilize AM tissue grafts while simultaneously preserving their biological attributes. The preservation of these features make AM appealing for use in numerous clinical and tissue engineering applications. C1 [Wehmeyer, Jennifer L.; Natesan, Shanmugasundaram; Christy, Robert J.] US Army Inst Surg Res, Extrem Trauma Res & Regenerat Med, Jbsa Ft Sam Houston, TX 78234 USA. RP Christy, RJ (reprint author), US Army Inst Surg Res, Extrem Trauma Res & Regenerat Med, Jbsa Ft Sam Houston, TX 78234 USA. EM robert.j.christy12.civ@mail.mil OI Natesan, Shanmugasundaram/0000-0003-4213-3111 FU Clinical and Rehabilitative Medicine Research Program, U.S Army Medical Research and Materiel Command FX The authors would like to thank the Alamo Tissue Service for use of their equipment and facilities; Dr. Tao You of the USAISR for assistance acquiring the SEM images; Ms. Sandra Becerra of the USAISR for her technical support; and Dr. Henry Rawls of the University of Texas Health Science Center San Antonio for use of his DSC equipment. Jennifer Wehmeyer's funding was provided by the Clinical and Rehabilitative Medicine Research Program, U.S Army Medical Research and Materiel Command. NR 47 TC 2 Z9 2 U1 1 U2 4 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1937-3384 EI 1937-3392 J9 TISSUE ENG PART C-ME JI Tissue Eng. Part C-Methods PD JUL 1 PY 2015 VL 21 IS 7 BP 649 EP 659 DI 10.1089/ten.tec.2014.0304 PG 11 WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell Biology SC Cell Biology; Biotechnology & Applied Microbiology GA CV0GY UT WOS:000363929600002 PM 25471248 ER PT J AU Dobson, CP Eide, M Nylund, CM AF Dobson, Craig P. Eide, Matilda Nylund, Cade M. TI Hypertension Prevalence, Cardiac Complications, and Antihypertensive Medication Use in Children SO JOURNAL OF PEDIATRICS LA English DT Article ID LEFT-VENTRICULAR HYPERTROPHY; AMERICAN-HEART-ASSOCIATION; HIGH BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE; SCIENTIFIC STATEMENT; RISK-FACTORS; ADOLESCENTS; CHILDHOOD; OBESITY; TRENDS AB Objective To determine the prevalence of hypertension diagnosis in children of US military members and quantify echocardiography evaluations, cardiac complications, and antihypertensive prescriptions in the post-2004 guideline era. Study design Using billing data from military health insurance (TRICARE) enrollees, hypertension cases were defined as 2 or more visits with a primary or unspecified hypertension diagnosis during any calendar year or 1 such visit if with a cardiologist or nephrologist. Results During 2006-2011, the database contained an average 1.3 million subjects aged 2-18 years per year. A total of 16 322 met the definition of hypertension (2.6/1000). The incidence of hypertension increased by 17% between 2006 and 2011 (from 2.3/1000 to 2.7/1000; P < .001). Hypertension was more common in adolescents aged 12-18 years than in younger children (5.4/1000 vs 0.9/1000). Among patients with hypertension, 5585 (34%) underwent echocardiography. The frequency of annual echocardiograms increased from 22.7% to 27.7% (P < .001). In patients with echocardiography, 8.0% had left ventricular hypertrophy or dysfunction. Among the patients with hypertension, 6353 (38.9%) received an antihypertensive medication. Conclusion The prevalence of hypertension in children has increased. Compliance with national guidelines is poor. Of pediatric patients with hypertension who receive an echocardiogram, 1 in 12 had identified cardiac complications, supporting the current recommendations for echocardiography in children with hypertension. Less than one-half of children with hypertension are treated with medication. C1 [Dobson, Craig P.] Tripler Army Med Ctr, Dept Pediat, Honolulu, HI 96859 USA. [Dobson, Craig P.; Eide, Matilda; Nylund, Cade M.] Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA. RP Dobson, CP (reprint author), Tripler Army Med Ctr, Dept Pediat, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM Craig.p.dobson.mil@mail.mil OI Nylund, Cade/0000-0003-4543-6804 FU NCATS NIH HHS [UL1 TR001425, UL1 TR000077] NR 26 TC 6 Z9 7 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-3476 EI 1097-6833 J9 J PEDIATR-US JI J. Pediatr. PD JUL PY 2015 VL 167 IS 1 BP 92 EP U456 DI 10.1016/j.jpeds.2015.04.016 PG 7 WC Pediatrics SC Pediatrics GA CS9ZS UT WOS:000362453900024 PM 25957976 ER PT J AU Peng, ZM Gurram, P Kwon, H Yin, WT AF Peng, Zhimin Gurram, Prudhvi Kwon, Heesung Yin, Wotao TI Sparse Kernel Learning-Based Feature Selection for Anomaly Detection SO IEEE TRANSACTIONS ON AEROSPACE AND ELECTRONIC SYSTEMS LA English DT Article ID HYPERSPECTRAL IMAGERY; TARGET RECOGNITION; ALGORITHM AB In this paper, a novel framework of sparse kernel learning for support vector data description (SVDD) based anomaly detection is presented. By introducing 0-1 control variables to original features in the input space, sparse feature selection for anomaly detection is modeled as a mixed integer programming problem. Due to the prohibitively high computational complexity, it is relaxed into a quadratically constrained linear programming (QCLP) problem. The QCLP problem can then be practically solved by using an iterative optimization method, in which multiple subsets of features are iteratively found as opposed to a single subset. However, when a nonlinear kernel such as Gaussian radial basis function kernel, associated with an infinite-dimensional reproducing kernel Hilbert space (RKHS) is used in the QCLP-based iterative optimization, it is impractical to find optimal subsets of features due to a large number of possible combinations of the original features. To tackle this issue, a feature map called the empirical kernel map, which maps data points in the input space into a finite space called the empirical kernel feature space (EKFS), is used in the proposed work. The QCLP-based iterative optimization problem is solved in the EKFS instead of in the input space or the RKHS. This is possible because the geometrical properties of the EKFS and the corresponding RKHS remain the same. Now, an explicit nonlinear exploitation of the data in a finite EKFS is achievable, which results in optimal feature ranking. Comprehensive experimental results on three hyperspectral images and several machine learning datasets show that our proposed method can provide improved performance over the current state-of-the-art techniques. C1 [Peng, Zhimin; Yin, Wotao] Univ Calif Los Angeles, Dept Math, Los Angeles, CA 90095 USA. [Gurram, Prudhvi] US Army Res Lab, Image Proc Branch, Adelphi, MD USA. [Kwon, Heesung] US Army Res Lab, Adelphi, MD USA. RP Peng, ZM (reprint author), Univ Calif Los Angeles, Dept Math, Los Angeles, CA 90095 USA. EM heesung.kwon@us.army.mil FU NSF [DMS-1317602]; ARO MURI [FA9550-10-1-0567] FX The research of W. Yin and Z. Peng were supported in part by NSF Grant DMS-1317602 and ARO MURI Grant FA9550-10-1-0567. NR 37 TC 0 Z9 0 U1 4 U2 18 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9251 EI 1557-9603 J9 IEEE T AERO ELEC SYS JI IEEE Trans. Aerosp. Electron. Syst. PD JUL PY 2015 VL 51 IS 3 BP 1698 EP 1716 DI 10.1109/TAES.2015.130730 PG 19 WC Engineering, Aerospace; Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA CS4AA UT WOS:000362015800009 ER PT J AU Hinojosa-Laborde, C Jespersen, B Shade, R AF Hinojosa-Laborde, Carmen Jespersen, Brian Shade, Robert TI Physiology Lab Demonstration: Glomerular Filtration Rate in a Rat SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS LA English DT Article DE Physiology; Issue 101; kidney; rat; glomerular filtration rate; urine flow rate; sodium excretion; potassium excretion; filtered load; blood pressure ID RENAL-FUNCTION; FITC-INULIN; CLEARANCE; ANESTHESIA; ANTHRONE; INFUSION; KIDNEY; MICE AB Measurements of glomerular filtration rate (GFR), and the fractional excretion of sodium (Na) and potassium (K) are critical in assessing renal function in health and disease. GFR is measured as the steady state renal clearance of inulin which is filtered at the glomerulus, but not secreted or reabsorbed along the nephron. The fractional excretion of Na and K can be determined from the concentration of Na and K in plasma and urine. The renal clearance of inulin can be demonstrated in an anesthetized animal which has catheters in the femoral artery, femoral vein and bladder. The equipment and supplies used for this procedure are those commonly available in a research core facility, and thus makes this procedure a practical means for measuring renal function. The purpose of this video is to demonstrate the procedures required to perform a lab demonstration in which renal function is assessed before and after a diuretic drug. The presented technique can be utilized to assess renal function in rat models of renal disease. C1 [Hinojosa-Laborde, Carmen] US Army, Inst Surg Res, Tact Combat Casualty Care Res, Edison, NJ USA. [Jespersen, Brian] Michigan State Univ, Dept Pharmacol & Toxicol, E Lansing, MI 48824 USA. [Shade, Robert] Texas Biomed Res Inst, Southwest Natl Primate Res Ctr, San Antonio, TX USA. RP Jespersen, B (reprint author), Michigan State Univ, Dept Pharmacol & Toxicol, E Lansing, MI 48824 USA. EM jespers1@msu.edu FU NIGMS [GM077119] FX The funding source for the lab demonstration was NIGMS grant: GM077119. We thank Dr. Joseph R. Haywood and Dr. Peter Cobbett for their support of the Short Couse in Integrative and Organ Systems Pharmacology. We also thank Ms. Hannah Garver for her technical support of the laboratory demonstration. NR 21 TC 0 Z9 0 U1 0 U2 1 PU JOURNAL OF VISUALIZED EXPERIMENTS PI CAMBRIDGE PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA SN 1940-087X J9 JOVE-J VIS EXP JI J. Vis. Exp. PD JUL PY 2015 IS 101 AR e52425 DI 10.3791/52425 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CR7ND UT WOS:000361536200011 PM 26274567 ER PT J AU Vuong, C Xie, LH Potter, BMJ Zhang, J Zhang, P Duan, DH Nolan, CK Sciotti, RJ Zottig, VE Nanayakkara, NPD Tekwani, BL Walker, LA Smith, PL Paris, RM Read, LT Li, QG Pybus, BS Sousa, JC Reichard, GA Smith, B Marcsisin, SR AF Vuong, Chau Xie, Lisa H. Potter, Brittney M. J. Zhang, Jing Zhang, Ping Duan, Dehui Nolan, Christina K. Sciotti, Richard J. Zottig, Victor E. Nanayakkara, N. P. Dhammika Tekwani, Babu L. Walker, Larry A. Smith, Philip L. Paris, Robert M. Read, Lisa T. Li, Qigui Pybus, Brandon S. Sousa, Jason C. Reichard, Gregory A. Smith, Bryan Marcsisin, Sean R. TI Differential Cytochrome P450 2D Metabolism Alters Tafenoquine Pharmacokinetics SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID PLASMODIUM-VIVAX MALARIA; ANTIMALARIAL-DRUG PRIMAQUINE; WR 238605; DOUBLE-BLIND; FALCIPARUM MALARIA; RAT ERYTHROCYTES; CYP 2D6; EFFICACY; 8-AMINOQUINOLINE; PROPHYLAXIS AB Cytochrome P450 (CYP) 2D metabolism is required for the liver-stage antimalarial efficacy of the 8-aminoquinoline molecule tafenoquine in mice. This could be problematic for Plasmodium vivax radical cure, as the human CYP 2D ortholog (2D6) is highly polymorphic. Diminished CYP 2D6 enzyme activity, as in the poor-metabolizer phenotype, could compromise radical curative efficacy in humans. Despite the importance of CYP 2D metabolism for tafenoquine liver-stage efficacy, the exact role that CYP 2D metabolism plays in the metabolism and pharmacokinetics of tafenoquine and other 8-aminoquinoline molecules has not been extensively studied. In this study, a series of tafenoquine pharmacokinetic experiments were conducted in mice with different CYP 2D metabolism statuses, including wild-type (WT) (reflecting extensive metabolizers for CYP 2D6 substrates) and CYPmouse 2D knockout (KO) (reflecting poor metabolizers for CYP 2D6 substrates) mice. Plasma and liver pharmacokinetic profiles from a single 20-mg/kg of body weight dose of tafenoquine differed between the strains; however, the differences were less striking than previous results obtained for primaquine in the same model. Additionally, the presence of a 5,6ortho- quinone tafenoquine metabolite was examined in both mouse strains. The 5,6-ortho-quinone species of tafenoquine was observed, and concentrations of the metabolite were highest in the WT extensive-metabolizer phenotype. Altogether, this study indicates that CYP 2D metabolism in mice affects tafenoquine pharmacokinetics and could have implications for human tafenoquine pharmacokinetics in polymorphic CYP 2D6 human populations. C1 [Vuong, Chau; Xie, Lisa H.; Potter, Brittney M. J.; Zhang, Jing; Zhang, Ping; Duan, Dehui; Nolan, Christina K.; Sciotti, Richard J.; Zottig, Victor E.; Smith, Philip L.; Paris, Robert M.; Read, Lisa T.; Li, Qigui; Pybus, Brandon S.; Sousa, Jason C.; Reichard, Gregory A.; Marcsisin, Sean R.] Walter Reed Army Inst Res, Mil Malaria Res Program, Div Expt Therapeut, Silver Spring, MD 20910 USA. [Nanayakkara, N. P. Dhammika; Tekwani, Babu L.; Walker, Larry A.] Natl Ctr Nat Prod Res, Oxford, MS USA. [Tekwani, Babu L.; Walker, Larry A.] Univ Mississippi, Sch Pharm, Dept Biomol Sci, Oxford, MS USA. [Smith, Bryan] US Army, Med Mat Dev Act, Frederick, MD USA. RP Marcsisin, SR (reprint author), Walter Reed Army Inst Res, Mil Malaria Res Program, Div Expt Therapeut, Silver Spring, MD 20910 USA. EM sean.r.marcsisin.mil@mail.mil FU Joint Warfighter Medical Research Program (JWMRP) [W81XWH1320026]; Military Infectious Diseases Research Program (MIDRP) [Q0302_12_WR_CS] FX This work was supported in part by Joint Warfighter Medical Research Program (JWMRP) award number W81XWH1320026 and Military Infectious Diseases Research Program (MIDRP) project number Q0302_12_WR_CS. NR 33 TC 7 Z9 7 U1 2 U2 9 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD JUL PY 2015 VL 59 IS 7 BP 3864 EP 3869 DI 10.1128/AAC.00343-15 PG 6 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA CQ8YF UT WOS:000360896000021 PM 25870069 ER PT J AU Kleinfelter, LM Jangra, RK Jae, LT Herbert, AS Mittler, E Stiles, KM Wirchnianski, AS Kielian, M Brummelkamp, TR Dye, JM Chandran, K AF Kleinfelter, Lara M. Jangra, Rohit K. Jae, Lucas T. Herbert, Andrew S. Mittler, Eva Stiles, Katie M. Wirchnianski, Ariel S. Kielian, Margaret Brummelkamp, Thijn R. Dye, John M. Chandran, Kartik TI Haploid Genetic Screen Reveals a Profound and Direct Dependence on Cholesterol for Hantavirus Membrane Fusion SO MBIO LA English DT Article ID VIRUS ENTRY REQUIRES; SEMLIKI-FOREST-VIRUS; CLEAVAGE-ACTIVATING PROTEIN; HEMORRHAGIC-FEVER; HANTAAN-VIRUS; RENAL SYNDROME; GLYCOPROTEIN PRECURSOR; SUBTILASE SKI-1/S1P; PULMONARY SYNDROME; BETA(3) INTEGRINS AB Hantaviruses cause hemorrhagic fever with renal syndrome (HFRS) in the Old World and a highly fatal hantavirus cardiopulmonary syndrome (HCPS) in the New World. No vaccines or antiviral therapies are currently available to prevent or treat hantavirus disease, and gaps in our understanding of how hantaviruses enter cells challenge the search for therapeutics. We performed a haploid genetic screen in human cells to identify host factors required for entry by Andes virus, a highly virulent New World hantavirus. We found that multiple genes involved in cholesterol sensing, regulation, and biosynthesis, including key components of the sterol response element-binding protein (SREBP) pathway, are critical for Andes virus entry. Genetic or pharmacological disruption of the membrane-bound transcription factor peptidase/site-1 protease (MBTPS1/S1P), an SREBP control element, dramatically reduced infection by virulent hantaviruses of both the Old World and New World clades but not by rhabdoviruses or alphaviruses, indicating that this pathway is broadly, but selectively, required by hantaviruses. These results could be fully explained as arising from the modest depletion of cellular membrane cholesterol that accompanied S1P disruption. Mechanistic studies of cells and with protein-free liposomes suggested that high levels of cholesterol are specifically needed for hantavirus membrane fusion. Taken together, our results indicate that the profound dependence on target membrane cholesterol is a fundamental, and unusual, biophysical property of hantavirus glycoprotein-membrane interactions during entry. IMPORTANCE Although hantaviruses cause important human diseases worldwide, no specific antiviral treatments are available. One of the major obstacles to the development of new therapies is a lack of understanding of how hantaviruses hijack our own host factors to enter cells. Here, we identified multiple cellular genes that control the levels of cholesterol in cellular membranes to be important for hantavirus entry. Our findings suggest that high concentrations of cholesterol in cellular membranes are required at a specific step in the entry process-fusion between viral and cellular membranes-that allows escape of the hantavirus genome into the host cell cytoplasm to initiate infection. Our findings uncover a fundamental feature of the hantavirus infection mechanism and point to cholesterol-lowering drugs as a potential new treatment of hantaviral infections. C1 [Kleinfelter, Lara M.; Jangra, Rohit K.; Mittler, Eva; Chandran, Kartik] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10467 USA. [Jae, Lucas T.; Brummelkamp, Thijn R.] Netherlands Canc Inst, Amsterdam, Netherlands. [Herbert, Andrew S.; Wirchnianski, Ariel S.; Dye, John M.] US Army Med Res Inst Infect Dis, Ft Detrick, MD USA. [Stiles, Katie M.; Kielian, Margaret] Albert Einstein Coll Med, Dept Cell Biol, Bronx, NY 10467 USA. RP Chandran, K (reprint author), Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10467 USA. EM john.m.dye1.civ@mail.mil; kartik.chandran@einstein.yu.edu FU NIH [R01 AI088027, R01 GM057454]; JSTO-CBD Defense Threat Reduction Agency [CB3947]; European Research Council (ERC) [ERC-2012-StG 309634]; Irma T. Hirschl/Monique Weill-Caulier Trust; Harold and Muriel Block Faculty Scholarship at the Albert Einstein College of Medicine; NIH Training Program in Cellular and Molecular Biology and Genetics [T32 GM007491] FX This work was supported by NIH grants R01 AI088027 (to K.C.) and R01 GM057454 (to M.K.), a JSTO-CBD Defense Threat Reduction Agency grant from project CB3947 (to J.M.D.), and a European Research Council (ERC) starting grant (ERC-2012-StG 309634) (to T.R.B.). K.C. was additionally supported by a fellowship from the Irma T. Hirschl/Monique Weill-Caulier Trust and by a Harold and Muriel Block Faculty Scholarship at the Albert Einstein College of Medicine. L.M.K. was additionally supported by the NIH Training Program in Cellular and Molecular Biology and Genetics (grant T32 GM007491). NR 73 TC 9 Z9 9 U1 1 U2 7 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 2150-7511 J9 MBIO JI mBio PD JUL-AUG PY 2015 VL 6 IS 4 AR e00801-15 DI 10.1128/mBio.00801-15 PG 14 WC Microbiology SC Microbiology GA CQ8EN UT WOS:000360839400013 PM 26126854 ER PT J AU Sanchez, JL Cooper, MJ Myers, CA Cummings, JF Vest, KG Russell, KL Sanchez, JL Hiser, MJ Gaydos, CA AF Sanchez, Jose L. Cooper, Michael J. Myers, Christopher A. Cummings, James F. Vest, Kelly G. Russell, Kevin L. Sanchez, Joyce L. Hiser, Michelle J. Gaydos, Charlotte A. TI Respiratory Infections in the US Military: Recent Experience and Control SO CLINICAL MICROBIOLOGY REVIEWS LA English DT Review ID INFLUENZA-A H1N1; COMMUNITY-ACQUIRED PNEUMONIA; HEALTH-CARE WORKERS; REAL-TIME PCR; DEPARTMENT-OF-DEFENSE; BACTEREMIC PNEUMOCOCCAL PNEUMONIA; IMMUNIZATION PRACTICES ACIP; DRUG-RESISTANT TUBERCULOSIS; RANDOMIZED CONTROLLED-TRIAL; SYNCYTIAL VIRUS-INFECTION AB This comprehensive review outlines the impact of military-relevant respiratory infections, with special attention to recruit training environments, influenza pandemics in 1918 to 1919 and 2009 to 2010, and peacetime operations and conflicts in the past 25 years. Outbreaks and epidemiologic investigations of viral and bacterial infections among high-risk groups are presented, including (i) experience by recruits at training centers, (ii) impact on advanced trainees in special settings, (iii) morbidity sustained by shipboard personnel at sea, and (iv) experience of deployed personnel. Utilizing a pathogen-by-pathogen approach, we examine (i) epidemiology, (ii) impact in terms of morbidity and operational readiness, (iii) clinical presentation and outbreak potential, (iv) diagnostic modalities, (v) treatment approaches, and (vi) vaccine and other control measures. We also outline military-specific initiatives in (i) surveillance, (ii) vaccine development and policy, (iii) novel influenza and coronavirus diagnostic test development and surveillance methods, (iv) influenza virus transmission and severity prediction modeling efforts, and (v) evaluation and implementation of nonvaccine, nonpharmacologic interventions. C1 [Sanchez, Jose L.; Cooper, Michael J.; Cummings, James F.; Vest, Kelly G.; Russell, Kevin L.; Hiser, Michelle J.] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD 20910 USA. [Myers, Christopher A.] Naval Hlth Res Ctr, San Diego, CA USA. [Sanchez, Joyce L.] Mayo Clin, Div Gen Internal Med, Rochester, MN USA. [Hiser, Michelle J.] US Army Publ Hlth Command, Oak Ridge Inst Sci & Educ, Postgrad Res Participat Program, Aberdeen, MD USA. [Gaydos, Charlotte A.] Johns Hopkins Univ, Div Infect Dis, Int STD Resp & Biothreat Res Lab, Baltimore, MD USA. RP Sanchez, JL (reprint author), Armed Forces Hlth Surveillance Ctr, Silver Spring, MD 20910 USA. EM jose.l.sanchez76.ctr@mail.mil FU Global Emerging Infections Surveillance and Response Division at the Armed Forces Health Surveillance Center FX Michelle J. Hiser's work in collating routine surveillance data, reports, and publications included in this project was partially supported by an appointment to the Postgraduate Research Participation Program administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USAPHC. This work was funded by the Global Emerging Infections Surveillance and Response Division at the Armed Forces Health Surveillance Center. NR 703 TC 5 Z9 5 U1 5 U2 27 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0893-8512 EI 1098-6618 J9 CLIN MICROBIOL REV JI Clin. Microbiol. Rev. PD JUL PY 2015 VL 28 IS 3 BP 743 EP 800 DI 10.1128/CMR.00039-14 PG 58 WC Microbiology SC Microbiology GA CQ3IH UT WOS:000360495000008 PM 26085551 ER PT J AU Aycrigg, JL Belote, RT Dietz, MS Aplet, GH Fischer, RA AF Aycrigg, Jocelyn L. Belote, R. Travis Dietz, Matthew S. Aplet, Gregory H. Fischer, Richard A. TI Bombing for Biodiversity in the United States: Response to Zentelis & Lindenmayer 2015 SO CONSERVATION LETTERS LA English DT Letter DE Biodiversity; Department of Defense; ecological systems; military training areas; representation; United States C1 [Aycrigg, Jocelyn L.] Univ Idaho, Dept Fish & Wildlife Sci, Moscow, ID 83844 USA. [Belote, R. Travis] Wilderness Soc, Bozeman, MT USA. [Dietz, Matthew S.] Wilderness Soc, San Francisco, CA USA. [Aplet, Gregory H.] Wilderness Soc, Denver, CO USA. [Fischer, Richard A.] US Army Engineer R&D Ctr, Environm Lab, Vicksburg, MS USA. RP Aycrigg, JL (reprint author), Univ Idaho, Dept Fish & Wildlife Sci, 875 Perimeter Dr MS-1136, Moscow, ID 83844 USA. EM aycrigg@uidaho.edu NR 6 TC 1 Z9 1 U1 5 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1755-263X J9 CONSERV LETT JI Conserv. Lett. PD JUL-AUG PY 2015 VL 8 IS 4 BP 306 EP 307 DI 10.1111/conl.12197 PG 2 WC Biodiversity Conservation SC Biodiversity & Conservation GA CQ2SM UT WOS:000360451400010 ER PT J AU Warr, BJ Fellin, RE Sauer, SG Goss, DL Frykman, PN Seay, JF AF Warr, Bradley J. Fellin, Rebecca E. Sauer, Shane G. Goss, Donald L. Frykman, Peter N. Seay, Joseph F. TI Characterization of Foot-Strike Patterns: Lack of an Association With Injuries or Performance in Soldiers SO MILITARY MEDICINE LA English DT Article ID RUNNING INJURIES; RUNNERS; BAREFOOT; DISABILITY; MARATHON AB Objectives: Characterize the distribution of foot-strike (FS) patterns in U.S. Army Soldiers and determine if FS patterns are related to self-reported running injuries and performance. Methods: 341 male Soldiers from a U.S. Army Combined Arms Battalion ran at their training pace for 100 meters, and FSs were recorded in the sagittal plane. Participants also completed a survey related to training habits, injury history, and run times. Two researchers classified FS patterns as heel strike (HS) or nonheel strike (NHS, combination of midfoot strike and forefoot strike patterns). Two clinicians classified the musculoskeletal injuries as acute or overuse. The relationship of FS type with two-mile run time and running-related injury was analyzed (p = 0.05). Results: The Soldiers predominately landed with an HS (87%) and only 13% were characterized as NHS. Running-related injury was similar between HS (50.3%) and NHS (55.6%) patterns (p = 0.51). There was no difference (p = 0.14) between overuse injury rates between an HS pattern (31.8%) and an NHS pattern (31.0%). Two-mile run times were also similar, with both groups averaging 14: 48 minutes. Conclusion: Soldiers were mostly heel strikers (87%) in this U.S. Army Combined Arms Battalion. Neither FS pattern was advantageous for increased performance or decreased incidence of running-related injury. C1 [Warr, Bradley J.; Fellin, Rebecca E.; Sauer, Shane G.; Frykman, Peter N.; Seay, Joseph F.] US Army Res Inst Environm Med, Mil Performance Div, Natick, MA 01760 USA. [Goss, Donald L.] Keller Army Community Hosp, West Point, NY 10996 USA. [Goss, Donald L.] Army Med Dept Ctr & Sch, Ft Sam Houston, TX 78234 USA. RP Warr, BJ (reprint author), US Army Res Inst Environm Med, Mil Performance Div, 15 Kansas St, Natick, MA 01760 USA. FU U.S. Army Research Institute of Environmental Medicine FX Research supported in part by appointments (R.E.F., S.G.S.) to the Postgraduate Research Participation program funded by U.S. Army Research Institute of Environmental Medicine & administered by Oak Ridge Institute for Science and Engineering. The authors thank the 1-66 Armor Battalion from Fort Carson, CO, for their participation, particularly the coordination efforts of CPT Anthony Spalloni. The authors also thank Ms. Amanda Winkler and Ms. Caitlin Dillon for their assistance in data management. NR 21 TC 1 Z9 1 U1 0 U2 6 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JUL PY 2015 VL 180 IS 7 BP 830 EP 834 DI 10.7205/MILMED-D-14-00220 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA CQ3SU UT WOS:000360523600028 PM 26126256 ER PT J AU Schierkolk, A AF Schierkolk, Andrea TI HAM, A Space Pioneer SO MILITARY MEDICINE LA English DT Editorial Material C1 US Army Med Res & Mat Command, Natl Museum Hlth & Med, Silver Spring, MD 20910 USA. RP Schierkolk, A (reprint author), US Army Med Res & Mat Command, Natl Museum Hlth & Med, 2500 Linden Lane, Silver Spring, MD 20910 USA. NR 3 TC 0 Z9 0 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JUL PY 2015 VL 180 IS 7 BP 835 EP 836 DI 10.7205/MILMED-D-15-00033 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA CQ3SU UT WOS:000360523600029 PM 26126257 ER PT J AU Charny, G Booms, Z McDonough, P Schauer, S AF Charny, Grigory Booms, Zachary McDonough, Patrick Schauer, Steven TI Airborne Priapism: A Case of Nonischemic Priapism After Military Static-Line Parachute Injury SO MILITARY MEDICINE LA English DT Article ID MANAGEMENT AB We report the case of a 21-year-old active duty U.S. Army soldier with painful and nonresolving priapism following blunt pelvic and lower extremity trauma from military static-line parachute injury during training. The patient's condition was initially managed with corporal aspiration and intracavernosal injections of phenylephrine that provided temporary relief but recurrence soon after. Referral to Urology at the site of the patient's injury yielded a diagnosis of penile hematoma. On subsequent evaluation by Urology on return to the patient's home duty station (over 96 hours after injury, with symptoms persisting), the corpora cavernosa were rigid, the corpus spongiosum was soft, and corporal blood gas drawn by the emergency department consistent with arterial blood. Penile duplex ultrasound revealed an isolated arterial-cavernosal fistula within the proximal left corporal body. The patient underwent percutaneous embolization of the fistula with successful resolution of his condition and return of normal erectile function. We discuss this unique case of high-flow priapism occurring after blunt trauma from military parachute injury and review suggested management in a stepwise fashion. The case is significant in that extensive literature review yields no previously described case of priapism following trauma from military parachute injury. C1 [Charny, Grigory] Womack Army Med Ctr, Dept Emergency Med, Ft Bragg, NC 28307 USA. [Booms, Zachary] 122 Aviat Support Battal, Combat Aviat Brigade 82, Ft Bragg, NC 28310 USA. [McDonough, Patrick] Womack Army Med Ctr, Urol Serv, Ft Bragg, NC 28307 USA. [Schauer, Steven] Bayne Jones Army Community Hosp, Dept Emergency Med, Fort Polk, LA 71459 USA. RP Charny, G (reprint author), Womack Army Med Ctr, Dept Emergency Med, 2817 Reilly Rd, Ft Bragg, NC 28307 USA. NR 6 TC 0 Z9 0 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JUL PY 2015 VL 180 IS 7 BP E853 EP E857 DI 10.7205/MILMED-D-14-00483 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA CQ3SU UT WOS:000360523600005 PM 26126262 ER PT J AU Oldani, A Valco, D Min, K Edwards, J Kweon, CB Allen, C Lee, T AF Oldani, Anna Valco, Daniel Min, Kyungwook Edwards, James Kweon, Chol-Bum Allen, Casey Lee, Tonghun TI Conventional and Bio-Derived Jet Fuel Surrogate Modeling in Low Temperature and Lean Combustion SO ENERGY & FUELS LA English DT Article; Proceedings Paper CT 2nd International Conference Biogas Science CY 2014 CL Vienna, AUSTRIA ID AUTOIGNITION CHARACTERISTICS; OXIDATION; IGNITION; JP-8; BEHAVIOR; CAMELINA; KINETICS AB Recently published chemical kinetic mechanisms are used to evaluate autoignition characteristics for conventional and alternative hydrotreated renewable jet (HRJ) fuels at low temperature and under lean combustion conditions. These kinetic models are examined for their predictive capabilities of ignition delay times compared against previously obtained experimental results from direct test chamber rapid compression machine (RCM) tests. Cases were evaluated at P-c = 20 bar in the low temperature (T-c = 630-730 K) and lean mixture (phi = 0.25 and 0.50) operating limits. The Ranzi mechanism was used for further simulation analysis in this work, where two-component jet fuel blends were developed to model camelina-based hydrotreated renewable jet fuels (HRJ-5 and HRJ-8), and the published conventional jet fuel surrogate of the Ranzi mechanism was used to represent both JP-5 and JP-8 jet fuels. Modeling results generally agree with RCM test results, indicating greater reactivity for the mostly paraffinic HRJ fuels at both mixture conditions. The kinetic models accurately capture the unique, multistage ignition observed in experimental results for the extra lean (phi = 0.25) case. Further analysis suggests several reactions potentially responsible for this unique ignition trend, namely, CO oxidation through the CO + OH --> CO2 + H and CO + HO2 --> CO2 + OH reactions, resulting in a mild third stage ignition for phi = 0.25 conditions. Additional examination of H-2 production and destruction reactions reveals similar reactions occurring in conventional and alternative jet fuels with CO-H-2-O-2 kinetics dominating the final stage oxidation kinetics. C1 [Oldani, Anna; Min, Kyungwook; Lee, Tonghun] Univ Illinois, Dept Mech Sci & Engn, Urbana, IL 61801 USA. [Valco, Daniel] Univ Illinois, Dept Chem & Biomol Engn, Urbana, IL 61801 USA. [Edwards, James] US Air Force, Res Lab, Wright Patterson AFB, OH 45433 USA. [Kweon, Chol-Bum] US Army, Res Lab, Aberdeen, MD 21005 USA. [Allen, Casey] Marquette Univ, Dept Mech Engn, Milwaukee, WI 53233 USA. RP Lee, T (reprint author), Univ Illinois, Dept Mech Sci & Engn, Urbana, IL 61801 USA. EM tonghun@illinois.edu RI Kweon, Chol-Bum/G-5425-2016 FU Office of Naval Research [N00014-14-1-0212]; National Science Foundation [DGE-1144245] FX The authors gratefully recognize the support of the Office of Naval Research under Grant N00014-14-1-0212. This material is based upon work supported by the National Science Foundation Graduate Research Fellowship Program under Grant DGE-1144245. Finally, the authors would like to acknowledge Dr. Robert Morris from the Naval Research Laboratory for his fuel composition analysis work. NR 23 TC 1 Z9 2 U1 2 U2 16 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0887-0624 EI 1520-5029 J9 ENERG FUEL JI Energy Fuels PD JUL PY 2015 VL 29 IS 7 BP 4597 EP 4607 DI 10.1021/acs.energyfuels.5b00917 PG 11 WC Energy & Fuels; Engineering, Chemical SC Energy & Fuels; Engineering GA CP6VS UT WOS:000360026900065 ER PT J AU Skyllingstad, ED Shell, KM Collins, L Polashenski, C AF Skyllingstad, Eric D. Shell, Karen M. Collins, Lee Polashenski, Chris TI Simulation of the melt season using a resolved sea ice model with snow cover and melt ponds SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article ID SURFACE; BALANCE; SHEBA AB A three-dimensional sea ice model is presented with resolved snow thickness variations and melt ponds. The model calculates heating from solar radiative transfer and simulates the formation and movement of brine/melt water through the ice system. Initialization for the model is based on observations of snow topography made during the summer melt seasons of 2009, 2010, and 2012 from a location off the coast of Barrow, AK. Experiments are conducted to examine the importance of snow properties and snow and ice thickness by comparing observed and modeled pond fraction and albedo. One key process simulated by the model is the formation of frozen layers in the ice as relatively warm fresh water grid cells freeze when cooled by adjacent, cold brine-filled grid cells. These layers prevent vertical drainage and lead to flooding of melt water commonly observed at the beginning of the melt season. Flooding persists until enough heat is absorbed to melt through the frozen layer. The resulting long-term melt pond coverage is sensitive to both the spatial variability of snow cover and the minimum snow depth. For thin snow cover, initial melting results in earlier, reduced flooding with a small change in pond fraction after drainage of the melt water. Deeper snow tends to generate a delayed, larger peak pond fraction before drainage. C1 [Skyllingstad, Eric D.; Shell, Karen M.; Collins, Lee] Oregon State Univ, Coll Earth Ocean & Atmospher Sci, Corvallis, OR 97331 USA. [Polashenski, Chris] US Army, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, Hanover, NH 03755 USA. RP Skyllingstad, ED (reprint author), Oregon State Univ, Coll Earth Ocean & Atmospher Sci, Corvallis, OR 97331 USA. EM skylling@coas.oregonstate.edu RI Shell, Karen/C-5161-2009 OI Shell, Karen/0000-0002-9059-6842 FU National Science Foundation [ARC-1022991]; National Science Foundation FX This research was funded by the National Science Foundation grant ARC-1022991. We would like to acknowledge high-performance computing support from Yellowstone (ark:/85065/d7wd3xhc) provided by NCAR's Computational and Information Systems Laboratory, sponsored by the National Science Foundation. Meteorological and net atmospheric radiation data from the U.S. Department of Energy as part of the Atmospheric Radiation Measurement (ARM) Climate Research Facility North Slope Alaska site were used in this study (available at http://www.arm.gov/). We would also like to thank Elizabeth Hunke and one anonymous reviewer for very constructive comments that greatly improved this paper. NR 26 TC 1 Z9 1 U1 0 U2 3 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-9275 EI 2169-9291 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD JUL PY 2015 VL 120 IS 7 BP 5194 EP 5215 DI 10.1002/2014JC010569 PG 22 WC Oceanography SC Oceanography GA CP3JU UT WOS:000359776000032 ER PT J AU Yalamanchili, C Manda, VK Chittiboyina, AG Harrell, WA Webb, RP Khan, IA AF Yalamanchili, C. Manda, V. K. Chittiboyina, A. G. Harrell, W. A., Jr. Webb, R. P. Khan, I. A. TI Identification of novel inhibitors of botulinum neurotoxin A SO PLANTA MEDICA LA English DT Meeting Abstract CT Annual Meeting of the American-Society-of-Pharmacognosy CY JUL 25-29, 2015 CL CO SP Amer Soc Pharmacognosy C1 [Yalamanchili, C.; Manda, V. K.; Chittiboyina, A. G.; Khan, I. A.] Univ Mississippi, Natl Ctr Nat Prod Res, University, MS 38677 USA. [Yalamanchili, C.; Khan, I. A.] Univ Mississippi, Dept BioMol Sci, Divison Pharmacognosy, University, MS 38677 USA. [Webb, R. P.] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU GEORG THIEME VERLAG KG PI STUTTGART PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY SN 0032-0943 EI 1439-0221 J9 PLANTA MED JI Planta Med. PD JUL PY 2015 VL 81 IS 11 MA PK12 BP 898 EP 898 PG 1 WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary Medicine; Pharmacology & Pharmacy SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary Medicine GA CP6AP UT WOS:000359967000206 ER PT J AU Huang, YM Rueda, LM AF Huang, Yiau-Min Rueda, Leopoldo M. TI PSEUDALBUGINOSUS, A NEW SUBGENUS OF AEDES, AND A REDESCRIPTION OF AEDES (PSEUDALBUGINOSUS) GRJEBINEI HAMON, TAUFFLIEB, AND MAILLOT (DIPTERA: CULICIDAE) SO PROCEEDINGS OF THE ENTOMOLOGICAL SOCIETY OF WASHINGTON LA English DT Article DE Pseudalbuginosus; new subgenus; Aedes grjebinei; characteristics; systematics; Culicidae; Gabon ID AFROTROPICAL REGION DIPTERA; ALLIED TAXA DIPTERA; LIFE STAGES; MORPHOLOGICAL DATA; AEDINI DIPTERA; PICTORIAL KEY; CLASSIFICATION; PHYLOGENY; OCHLEROTATUS AB Pseudalbuginosus, a new subgenus of Aedes Meigen, is characterized and diagnosed. Aedes grjebinei Hamon, Taufflieb, and Maillot is removed from the subgenus Aedimorphus Theobald and placed in the new monotypic subgenus Pseudalbuginosus on the basis of a critical study of all known specimens. The adult male and the male genitalia of Ae. (Pseudalbuginosus) grjebinei are described, with the illustration of the genitalia and images of the proboscis and maxillary palpi. Its affinity to other subgenera of the genus Aedes is discussed. Information on type data, distribution, bionomics, medical importance and a taxonomic discussion of this species are presented. C1 [Huang, Yiau-Min] Smithsonian Inst, Dept Entomol, Washington, DC 20013 USA. [Rueda, Leopoldo M.] Smithsonian Inst, Museum Support Ctr, WRBU, Suitland, MD 20746 USA. [Rueda, Leopoldo M.] Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD 20910 USA. RP Huang, YM (reprint author), Smithsonian Inst, Dept Entomol, POB 37012,MSC C1109,MRC 534, Washington, DC 20013 USA. EM huangy@si.edu; ruedapol@si.edu NR 18 TC 0 Z9 0 U1 1 U2 2 PU ENTOMOL SOC WASHINGTON PI WASHINGTON PA SMITHSONIAN INSTITUTION DEPT ENTOMOLOGY, WASHINGTON, DC 20560 USA SN 0013-8797 J9 P ENTOMOL SOC WASH JI Proc. Entomol. Soc. Wash. PD JUL PY 2015 VL 117 IS 3 BP 381 EP 388 DI 10.4289/0013-8797.117.3.381 PG 8 WC Entomology SC Entomology GA CP7GC UT WOS:000360054200006 ER PT J AU Matthews, SJ AF Matthews, Suzanne J. TI Heterogeneous Compression of Large Collections of Evolutionary Trees SO IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS LA English DT Article; Proceedings Paper CT International-Society-for-Computational-Biology (ISCB) as GIW ISCB Asia CY DEC 15-17, 2014 CL Tokyo Int Exchange Ctr, Tokyo Waterfront Area, Tokyo, JAPAN HO Tokyo Int Exchange Ctr, Tokyo Waterfront Area DE Phylogeny; heterogeneity; heterogeneous; compression; trees; collections; TreeZip ID BAYESIAN PHYLOGENETIC INFERENCE; MIXED MODELS; ALGORITHMS; EFFICIENT; MRBAYES AB Compressing heterogeneous collections of trees is an open problem in computational phylogenetics. In a heterogeneous tree collection, each tree can contain a unique set of taxa. An ideal compression method would allow for the efficient archival of large tree collections and enable scientists to identify common evolutionary relationships over disparate analyses. In this paper, we extend TreeZip to compress heterogeneous collections of trees. TreeZip is the most efficient algorithm for compressing homogeneous tree collections. To the best of our knowledge, no other domain-based compression algorithm exists for large heterogeneous tree collections or enable their rapid analysis. Our experimental results indicate that TreeZip averages 89.03 percent (72.69 percent) space savings on unweighted (weighted) collections of trees when the level of heterogeneity in a collection is moderate. The organization of the TRZ file allows for efficient computations over heterogeneous data. For example, consensus trees can be computed in mere seconds. Lastly, combining the TreeZip compressed (TRZ) file with general-purpose compression yields average space savings of 97.34 percent (81.43 percent) on unweighted (weighted) collections of trees. Our results lead us to believe that TreeZip will prove invaluable in the efficient archival of tree collections, and enables scientists to develop novel methods for relating heterogeneous collections of trees. C1 US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA. EM suzanne.matthews@usma.edu OI Matthews, Suzanne/0000-0001-9170-2240 FU US National Science Foundation [DEB-0629849, IIS-0713168, IIS-1018785]; Dissertation Fellowship program at Texas AM University FX The author is grateful for the mentorship of T.L. Williams in the earlier stages of this work. This work was supported by the US National Science Foundation under Grants DEB-0629849, IIS-0713168, and IIS-1018785. This work was also supported in part by the Dissertation Fellowship program at Texas A&M University. The opinions in this paper are those of the authors and do not necessarily reflect the opinions of the US Department of Defense, or the U.S. Army. NR 23 TC 0 Z9 0 U1 0 U2 4 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 1545-5963 EI 1557-9964 J9 IEEE ACM T COMPUT BI JI IEEE-ACM Trans. Comput. Biol. Bioinform. PD JUL-AUG PY 2015 VL 12 IS 4 BP 807 EP 814 DI 10.1109/TCBB.2014.2366756 PG 8 WC Biochemical Research Methods; Computer Science, Interdisciplinary Applications; Mathematics, Interdisciplinary Applications; Statistics & Probability SC Biochemistry & Molecular Biology; Computer Science; Mathematics GA CO6KF UT WOS:000359264900013 PM 26357320 ER PT J AU McCain, WC Crouse, LCB Bazar, MA Roszell, LE Leach, GJ Middleton, JR Reddy, G AF McCain, Wilfred C. Crouse, Lee C. B. Bazar, Mathew A. Roszell, Laurie E. Leach, Glenn J. Middleton, John R. Reddy, Gunda TI Subchronic Oral Toxicity of Sodium Tungstate in Sprague-Dawley Rats SO INTERNATIONAL JOURNAL OF TOXICOLOGY LA English DT Article DE sodium tungstate; CAS 10213-10-2; rats; 90-day study; subchronic toxicity oral toxicity; kidney toxicity ID CHURCHILL COUNTY; NEVADA; DISPOSITION; LEUKEMIA; RODENTS; SINGLE AB The subchronic toxicity of sodium tungstate dihydrate aqueous solution in male and female Sprague-Dawley rats was evaluated by daily oral gavage of 0, 10, 75, 125, or 200 mg/kg/d for 90 days. Measured parameters included food consumption, body weight measurements, hematology, clinical chemistry, and histopathological changes. There was a significant decrease in food consumption and body weight gain in males at 200 mg/kg/d from days 77 to 90; however, there was no effect in food consumption and body weights in females. There were no changes in the hematological and clinical parameters studied. Histopathological changes were seen in kidney of male and female and epididymis of male rats. Histopathological changes were observed in the kidneys of male and female rats dosed at 125 or 200 mg/k/d consisting of mild to severe cortical tubule basophilia in 2 high-dose groups. Histological changes in epididymides included intraluminal hypospermia with cell debris in the 200 mg/kg/d dosed male rats. Histopathological changes were observed in the glandular stomach including inflammation and metaplasia in the high-dose groups (125 or 200 mg/kg/d) of both sexes of rats. Based on histopathology effects seen in the kidneys, the lowest observable adverse effect level was 125 mg/kg/d and the no observable adverse effect level was 75 mg/kg/d in both sexes of rats for oral subchronic toxicity. C1 [McCain, Wilfred C.; Crouse, Lee C. B.; Bazar, Mathew A.; Roszell, Laurie E.; Leach, Glenn J.; Reddy, Gunda] US Army Publ Hlth Command, Toxicol Portfolio, Army Inst Publ Hlth, Aberdeen Proving Ground, MD 21010 USA. [Middleton, John R.] ARDEC, PM Maneuver Ammunit Syst MAS, Picatinny Arsenal, NJ USA. RP Reddy, G (reprint author), US Army Publ Hlth Command, Toxicol Portfolio, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM USarmy.apg.medcom-phc.mbx.tox-info@mail.mil FU Army Research Development and Engineering Center (ARDEC), Picatinny, NJ FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Financial support from Army Research Development and Engineering Center (ARDEC), Picatinny, NJ. NR 43 TC 1 Z9 1 U1 1 U2 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1091-5818 EI 1092-874X J9 INT J TOXICOL JI Int. J. Toxicol. PD JUL-AUG PY 2015 VL 34 IS 4 BP 336 EP 345 DI 10.1177/1091581815585568 PG 10 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA CO8FJ UT WOS:000359401300006 PM 26023051 ER PT J AU Kirawittaya, T Yoon, IK Wichit, S Green, S Ennis, FA Gibbons, RV Thomas, SJ Rothman, AL Kalayanarooj, S Srikiatkhachorn, A AF Kirawittaya, Tawatchai Yoon, In-Kyu Wichit, Sineewanlaya Green, Sharone Ennis, Francis A. Gibbons, Robert V. Thomas, Stephen J. Rothman, Alan L. Kalayanarooj, Siripen Srikiatkhachorn, Anon TI Evaluation of Cardiac Involvement in Children with Dengue by Serial Echocardiographic Studies SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID HEART-RATE-VARIABILITY; SERUM NITRIC-OXIDE; HEMORRHAGIC-FEVER; DIASTOLIC DYSFUNCTION; VIRAL-INFECTION; VIRUS-INFECTION; COMMUNITY; SOCIETY; STAGE AB Background Infection with dengue virus results in a wide range of clinical manifestations from dengue fever (DF), a self-limited febrile illness, to dengue hemorrhagic fever (DHF) which is characterized by plasma leakage and bleeding tendency. Although cardiac involvement has been reported in dengue, the incidence and the extent of cardiac involvement are not well defined. Methods and Principal findings We characterized the incidence and changes in cardiac function in a prospective in-patient cohort of suspected dengue cases by serial echocardiography. Plasma leakage was detected by serial chest and abdominal ultrasonography. Daily cardiac troponin-T levels were measured. One hundred and eighty one dengue cases were enrolled. On the day of enrollment, dengue cases that already developed plasma leakage had lower cardiac index (2695 (127) vs 3188 (75) (L/min/m(2)), p = .003) and higher left ventricular myocardial performance index (.413 (.021) vs.328 (.026), p = .021) and systemic vascular resistance (2478 (184) vs 1820 (133) (dynes.s/cm(5)), p = .005) compared to those without plasma leakage. Early diastolic wall motion of the left ventricle was decreased in dengue cases with plasma leakage compared to those without. Decreased left ventricular wall motility was more common in dengue patients compared to non-dengue cases particularly in cases with plasma leakage. Differences in cardiac function between DF and DHF were most pronounced around the time of plasma leakage. Cardiac dysfunction was transient and did not require treatment. Transient elevated troponin-T levels were more common in DHF cases compared to DF (14.5% vs 5%, p = 0.028). Conclusions Transient left ventricular systolic and diastolic dysfunction was common in children hospitalized with dengue and related to severity of plasma leakage. The functional abnormality spontaneously resolved without specific treatment. Cardiac structural changes including myocarditis were uncommon. C1 [Kirawittaya, Tawatchai; Kalayanarooj, Siripen] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand. [Yoon, In-Kyu; Wichit, Sineewanlaya] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Green, Sharone; Ennis, Francis A.; Srikiatkhachorn, Anon] Univ Massachusetts, Sch Med, Dept Med, Div Infect Dis & Immunol, Worcester, MA USA. [Gibbons, Robert V.] US Army Inst Surg Res, Inst Surg Res, Houston, TX USA. [Thomas, Stephen J.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD USA. [Rothman, Alan L.] Univ Rhode Isl, Inst Immunol & Informat, Providence, RI 02908 USA. RP Kirawittaya, T (reprint author), Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand. EM anon.srikiatkhachorn@umassmed.edu FU National Institutes of Health [NIH-P01AI34533]; Military Infectious Disease Research Program [S0328_11_AF_PP] FX This research was supported by the National Institutes of Health (NIH-P01AI34533 to SG, FAE, ALR, SK, AS) and Military Infectious Disease Research Program (S0328_11_AF_PP to SJT, RVG, IKY). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 43 TC 1 Z9 1 U1 0 U2 1 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD JUL PY 2015 VL 9 IS 7 AR e0003943 DI 10.1371/journal.pntd.0003943 PG 17 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA CO3SM UT WOS:000359079700046 PM 26226658 ER PT J AU Sivasuthan, S Karthik, VU Mathialakan, T Rawashdeh, MR Jayakumar, P Thyagarajan, RS Hoole, SRH AF Sivasuthan, Sivamayam Karthik, Victor U. Mathialakan, Thavappiragasam Rawashdeh, Mohammad R. Jayakumar, Paramsothy Thyagarajan, Ravi S. Hoole, S. Ratnajeevan. H. TI GRAPHICS PROCESSING UNIT COMPUTATIONS FOR FINITE ELEMENT OPTIMIZATION: A REVIEW AND SOME ISSUES TO BE ADDRESSED SO REVUE ROUMAINE DES SCIENCES TECHNIQUES-SERIE ELECTROTECHNIQUE ET ENERGETIQUE LA English DT Article DE Finite element method (FEM); Parallelization; Matrix computation; Graphics processing unit (GPU) ID OPTIMAL-DESIGN; ELECTROMAGNETIC DEVICES; GENETIC ALGORITHM; SHAPE OPTIMIZATION; GPU; FEM; MAGNET; FIELDS AB In finite element optimization, the computational load is a limiting issue. Parallelization has been the preferred route to overcome this problem but was again limited by the cost of computers and the number of processors available. The graphics processing unit (GPU) on a PC provides a means of implementing the massive computations on numerous parallel threads cheaply on PCs. The purpose of this is to review finite element matrix equation solution on the GPU and point out areas where further investigation is warranted. Our intention is to direct computational research and computer architecture development so that we may use the GPU better for more effective computational parallelization in finite element field computation. C1 [Sivasuthan, Sivamayam; Karthik, Victor U.; Mathialakan, Thavappiragasam; Rawashdeh, Mohammad R.; Hoole, S. Ratnajeevan. H.] Michigan State Univ, Dept Elect & Comp Engn, E Lansing, MI 48823 USA. [Jayakumar, Paramsothy; Thyagarajan, Ravi S.] US Army Tank Automot Res Dev & Engn Ctr, Warren, MI 48397 USA. RP Sivasuthan, S (reprint author), Michigan State Univ, Dept Elect & Comp Engn, E Lansing, MI 48823 USA. EM srhhoole@gmail.com FU us army's tardec [w911nf-11-d-0001] FX This work was funded in part by the us army's tardec under contract w911nf-11-d-0001. No copyright restrictions apply. distribution in the us without restriction (opsec ref. 24315). NR 40 TC 0 Z9 0 U1 1 U2 2 PU EDITURA ACAD ROMANE PI BUCURESTI PA CALEA 13 SEPTEMBRIE NR 13, SECTOR 5, BUCURESTI 050711, ROMANIA SN 0035-4066 J9 REV ROUM SCI TECH-EL JI Rev. Roum. Sci. Tech.-Ser. Electro. PD JUL-SEP PY 2015 VL 60 IS 3 BP 241 EP 251 PG 11 WC Engineering, Electrical & Electronic SC Engineering GA CP2BS UT WOS:000359683100003 ER PT J AU Lim, R AF Lim, Robert TI Comment on: Secondary surgery after sleeve gastrectomy: Roux-en-Y gastric bypass or biliopancreatic diversion with duodenal switch SO SURGERY FOR OBESITY AND RELATED DISEASES LA English DT Editorial Material C1 Tripler Army Med Ctr, Sect Gen Surg, Honolulu, HI 96859 USA. RP Lim, R (reprint author), Tripler Army Med Ctr, Sect Gen Surg, Honolulu, HI 96859 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1550-7289 EI 1878-7533 J9 SURG OBES RELAT DIS JI Surg. Obes. Relat. Dis. PD JUL-AUG PY 2015 VL 11 IS 4 BP 777 EP 778 PG 2 WC Surgery SC Surgery GA CO7HF UT WOS:000359329500006 PM 25533625 ER PT J AU Choi, Y AF Choi, Yong TI Comment on: Indications and outcomes of reversal of Roux-en-Y gastric bypass SO SURGERY FOR OBESITY AND RELATED DISEASES LA English DT Editorial Material ID LAPAROSCOPIC REVERSAL; NORMAL ANATOMY; SURGERY; HYPERTENSION; OBESITY C1 Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA. RP Choi, Y (reprint author), Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA. NR 9 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1550-7289 EI 1878-7533 J9 SURG OBES RELAT DIS JI Surg. Obes. Relat. Dis. PD JUL-AUG PY 2015 VL 11 IS 4 BP 826 EP 827 PG 2 WC Surgery SC Surgery GA CO7HF UT WOS:000359329500017 PM 25862178 ER PT J AU Choi, Y AF Choi, Yong TI Comment on: Hypoalbuminemia is disproportionately associated with adverse outcomes in obese elective surgical patients SO SURGERY FOR OBESITY AND RELATED DISEASES LA English DT Editorial Material ID NUTRITIONAL-STATUS; SURGERY C1 Dwight D Eisenhower Army Med Ctr, Gen Surg Clin, Ft Gordon, GA 30905 USA. RP Choi, Y (reprint author), Dwight D Eisenhower Army Med Ctr, Gen Surg Clin, Ft Gordon, GA 30905 USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1550-7289 EI 1878-7533 J9 SURG OBES RELAT DIS JI Surg. Obes. Relat. Dis. PD JUL-AUG PY 2015 VL 11 IS 4 BP 918 EP 919 PG 2 WC Surgery SC Surgery GA CO7HF UT WOS:000359329500036 PM 25465133 ER PT J AU Berger, ST Netherland, MD MacDonald, GE AF Berger, Sarah T. Netherland, Michael D. MacDonald, Gregory E. TI Development of a Rapid Assay to Detect Reduced Fluridone Sensitivity in Invasive Watermilfoils SO WEED TECHNOLOGY LA English DT Article DE Chlorophyll fluorescence; rapid assay; resistance detection ID HYDRILLA HYDRILLA-VERTICILLATA; EURASIAN WATERMILFOIL; EUHRYCHIOPSIS-LECONTEI; MYRIOPHYLLUM-SPICATUM; HYBRID WATERMILFOIL; LAKE; HERBICIDE; POPULATIONS; MILFOIL; WEEVIL AB Fluridone has been used to successfully manage Eurasian watermilfoil since the late 1980s. However, recent documentation of hybrid watermilfoils and the resulting potential for reduced herbicide sensitivity necessitate the need for an assay to determine individual population response to fluridone. A known fluridone-resistant hybrid watermilfoil population from Townline Lake in Michigan was compared to 11 Eurasian and hybrid watermilfoil populations in laboratory experiments to develop a method for determining response to fluridone. Apical shoot tips were exposed to increasing concentrations of fluridone (0 to 48 mu g L-1) for 3, 5, and 7 d. Chlorophyll fluorescence (F-v/F-m) was evaluated using a pulse-amplitude modulated fluorometer at each interval along with pigment analysis of chlorophyll and beta-carotene at the 7-d interval. F-v/F-m and pigment analysis yielded the same results. A fluridone concentration of 12 mu g L-1 and an analysis interval of 7 d were found to be optimal in determining invasive watermilfoil response to fluridone. Use of such small-scale assays can provide resource managers a rapid tool to cost-effectively evaluate invasive watermilfoil response to fluridone. C1 [Berger, Sarah T.; MacDonald, Gregory E.] Univ Florida, Dept Agron, Gainesville, FL 32611 USA. [Netherland, Michael D.] US Army, Engineer Res & Dev Ctr Biologist, Gainesville, FL 32653 USA. RP Netherland, MD (reprint author), US Army, Engineer Res & Dev Ctr Biologist, Gainesville, FL 32653 USA. EM mdnether@ufl.edu NR 28 TC 1 Z9 1 U1 7 U2 17 PU WEED SCI SOC AMER PI LAWRENCE PA 810 EAST 10TH ST, LAWRENCE, KS 66044-8897 USA SN 0890-037X EI 1550-2740 J9 WEED TECHNOL JI Weed Technol. PD JUL-SEP PY 2015 VL 29 IS 3 BP 605 EP 610 DI 10.1614/WT-D-14-00077.1 PG 6 WC Agronomy; Plant Sciences SC Agriculture; Plant Sciences GA CO8UU UT WOS:000359448400030 ER PT J AU Shi, C Xu, ZH Smolinski, BL Arienti, PM O'Connor, G Meng, XG AF Shi, Cong Xu, Zhonghou Smolinski, Benjamin L. Arienti, Per M. O'Connor, Gregory Meng, Xiaoguang TI Spectrophotometric analyses of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) in water SO JOURNAL OF ENVIRONMENTAL SCIENCES LA English DT Article DE Berthelot reaction; Exchange resins; RDX; Spectrophotometric method; Water ID BERTHELOT REACTION; ION-EXCHANGE; BIODEGRADATION; AMMONIUM; REMOVAL AB A simple and accurate spectrophotometric method for on-site analysis of royal demolition explosive (RDX) in water samples was developed based on the Berthelot reaction. The sensitivity and accuracy of an existing spectrophotometric method was improved by: replacing toxic chemicals with more stable and safer reagents; optimizing the reagent dose and reaction time; improving color stability; and eliminating the interference from inorganic nitrogen compounds in water samples. Cation and anion exchange resin cartridges were developed and used for sample pretreatment to eliminate the effect of ammonia and nitrate on RDX analyses. The detection limit of the method was determined to be 100 mu g/L. The method was used successfully for analysis of RDX in untreated industrial wastewater samples. It can be used for on-site monitoring of RDX in wastewater for early detection of chemical spills and failure of wastewater treatment systems. (C) 2015 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V. C1 [Shi, Cong; Xu, Zhonghou; Meng, Xiaoguang] Stevens Inst Technol, Ctr Environm Syst, Hoboken, NJ 07030 USA. [Smolinski, Benjamin L.; Arienti, Per M.; O'Connor, Gregory] US Army RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA. RP Meng, XG (reprint author), Stevens Inst Technol, Ctr Environm Syst, Hoboken, NJ 07030 USA. EM scgalileo@gmail.com; xmeng@stevens.edu RI Xu, Zhonghou/L-9969-2016 OI Xu, Zhonghou/0000-0003-4021-8154 NR 16 TC 0 Z9 0 U1 2 U2 7 PU SCIENCE PRESS PI BEIJING PA 16 DONGHUANGCHENGGEN NORTH ST, BEIJING 100717, PEOPLES R CHINA SN 1001-0742 EI 1878-7320 J9 J ENVIRON SCI-CHINA JI J. Environ. Sci. PD JUL 1 PY 2015 VL 33 BP 39 EP 44 DI 10.1016/j.jes.2015.02.001 PG 6 WC Environmental Sciences SC Environmental Sciences & Ecology GA CO2HE UT WOS:000358976000005 PM 26141876 ER PT J AU Colby, D Phanuphak, N Sirivichayakul, S Prueksakaew, P Saengtawan, P Trichavaroj, R Crowell, T Kim, J Ananworanich, J Phanuphak, P AF Colby, Donn Phanuphak, Nittaya Sirivichayakul, Sunee Prueksakaew, Peeriya Saengtawan, Putthachard Trichavaroj, Rapee Crowell, Trevor Kim, Jerome Ananworanich, Jintanat Phanuphak, Praphan CA RV254 SEARCH010 Study Grp TI HIV transmitted drug resistance declined from 2009 to 2014 among acutely infected MSM in Bangkok, Thailand SO JOURNAL OF THE INTERNATIONAL AIDS SOCIETY LA English DT Meeting Abstract C1 [Colby, Donn; Phanuphak, Nittaya; Prueksakaew, Peeriya; Saengtawan, Putthachard] SEARCH, Thai Red Cross AIDS Res Ctr, Bangkok, Thailand. [Sirivichayakul, Sunee] Chulalongkorn Univ Hosp, Bangkok, Thailand. [Trichavaroj, Rapee] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Crowell, Trevor; Kim, Jerome; Ananworanich, Jintanat] US Mil HIV Res Program, Bethesada, MD USA. [Phanuphak, Praphan] Thai Red Cross AIDS Res Ctr, Bangkok, Thailand. EM doctordonn@gmail.com NR 0 TC 0 Z9 0 U1 0 U2 2 PU INT AIDS SOCIETY PI GENEVA PA AVENUE DE FRANCE 23, GENEVA, 1202, SWITZERLAND SN 1758-2652 J9 J INT AIDS SOC JI J. Int. AIDS Soc. PD JUL PY 2015 VL 18 SU 4 MA WEAB0104 DI 10.7448/IAS.18.5.20401 PG 1 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA CN8FS UT WOS:000358675700114 ER PT J AU Fletcher, JLK Pinyakorn, S de Souza, M Akapirat, S Trichavaroj, R Pankam, T Kroon, E Colby, D Prueksakaew, P Suttichom, D Kim, JH Phanuphak, P Phanuphak, N Ananworanich, J AF Fletcher, James L. K. Pinyakorn, Suteeraporn de Souza, Mark Akapirat, Siriwat Trichavaroj, Rapee Pankam, Tippawan Kroon, Eugene Colby, Donn Prueksakaew, Peeriya Suttichom, Duanghathai Kim, Jerome H. Phanuphak, Praphan Phanuphak, Nittaya Ananworanich, Jintanat CA SEARCH10 RV254 Study Grp TI High rates of non-reactive HIV serology after antiretroviral treatment initiated in acute HIV infection SO JOURNAL OF THE INTERNATIONAL AIDS SOCIETY LA English DT Meeting Abstract C1 [Fletcher, James L. K.; de Souza, Mark; Kroon, Eugene; Colby, Donn; Prueksakaew, Peeriya; Suttichom, Duanghathai; Phanuphak, Nittaya] SEARCH, Thai Red Cross AIDS Res Ctr, Bangkok, Thailand. [Pinyakorn, Suteeraporn; Kim, Jerome H.; Ananworanich, Jintanat] US Mil HIV Res Program, Walter Reed Army Inst Res, Silver Spring, MD USA. [Akapirat, Siriwat; Trichavaroj, Rapee; Kroon, Eugene; Kim, Jerome H.] Armed Forces Res Inst Med Sci US Component, Dept Retrovirol, Bangkok, Thailand. [Pankam, Tippawan; Phanuphak, Praphan; Phanuphak, Nittaya] Thai Red Cross AIDS Res Ctr, Thai Red Cross Anonymous Clin, Bangkok, Thailand. [Phanuphak, Praphan] Chulalongkorn Univ, Fac Med, Dept Med, Bangkok 10330, Thailand. [Ananworanich, Jintanat] Henry M Jackson Fdn Advancement Mil Med, Bethesda, MD USA. EM james.f@searchthailand.org NR 0 TC 0 Z9 0 U1 0 U2 1 PU INT AIDS SOCIETY PI GENEVA PA AVENUE DE FRANCE 23, GENEVA, 1202, SWITZERLAND SN 1758-2652 J9 J INT AIDS SOC JI J. Int. AIDS Soc. PD JUL PY 2015 VL 18 SU 4 MA WEAB0102 DI 10.7448/IAS.18.5.20399 PG 1 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA CN8FS UT WOS:000358675700112 ER PT J AU Manno, EC Bamford, A Conejo, PR Marquez, L Mellado, MJ Munoz-Fernandez, MA Spoulou, V Klein, N Ananworanich, J Della Negra, M Ziegler, JB Meanson, E Lyall, H Shingadia, D Di Biagio, A Giacomet, V Vibeke, R Marques, HHD Salo, E Volokha, A Scherpbier, HJ Niehues, T Levy, J Marczynska, M Mardarescu, M Reliquet, V Giaquinto, C Bernardi, S Palma, P AF Manno, Emma Concetta Bamford, Alasdair Rojo Conejo, Pablo Marquez, Laura Jose Mellado, Maria Angeles Munoz-Fernandez, M. Spoulou, Vana Klein, Nigel Ananworanich, Jintanat Della Negra, Marinella Ziegler, John Bernard Meanson, Esse Lyall, Hermione Shingadia, Delane Di Biagio, Antonio Giacomet, Vania Vibeke, Rosenfeldt de Sousa Marques, Heloisa Helena Salo, Eeva Volokha, Alla Scherpbier, Henriette J. Niehues, Tim Levy, Jack Marczynska, Magdalena Mardarescu, Mariana Reliquet, Veronique Giaquinto, Carlo Bernardi, Stefania Palma, Paolo TI Immunization practice and vaccine safety perception in centres caring for children with prenatally acquired HIV: results from the Pediatric European Network for Treatment of AIDS survey SO JOURNAL OF THE INTERNATIONAL AIDS SOCIETY LA English DT Meeting Abstract C1 [Manno, Emma Concetta; Bernardi, Stefania; Palma, Paolo] Childrens Hosp Bambino Gesu, Unit Immune & Infect Dis, DPUO, Univ Dept Pediat, Rome, Italy. [Bamford, Alasdair] Guys & St Thomas NHS Fdn Trust, Evelina London Childrens Hosp, Dept Paediat Infect Dis & Immunol, London, England. [Rojo Conejo, Pablo] Hosp Univ Doce Octubre, Unidad Inmunodeficiencias Paediat, Serv Pediat, Madrid, Spain. [Marquez, Laura] Ctr Hosp Porto, Pediat Infect Dis & Immunodeficiencies Unit, Oporto, Portugal. [Jose Mellado, Maria] Hosp Univ Infantil La Paz Madrid, Serv Pediat & Enfermedades Infecciosas & Trop, Madrid, Spain. [Angeles Munoz-Fernandez, M.] Hosp Gen Univ Gregorio Maranon, Lab InmunoBiol Mol, Madrid, Spain. [Spoulou, Vana] Aghia Sophia Childrens Hosp, Dept Infect Dis, Athens, Greece. [Klein, Nigel] UCL, Inst Child Hlth, Infect Dis & Microbiol Unit, London, England. [Ananworanich, Jintanat] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Ananworanich, Jintanat] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Della Negra, Marinella] Inst Infectol Emilio Ribas, Sao Paulo, Brazil. [Ziegler, John Bernard] Sydney Childrens Hosp, Dept Immunol & Infect Dis, Sydney, NSW, Australia. [Meanson, Esse] Guys & St Thomas NHS Fdn Trust, Dept Paediat Infect Dis & Immunol, Evelina London Childrens Hosp, London, England. [Lyall, Hermione] Imperial Coll Healthcare NHS Trust, London, England. [Shingadia, Delane] Great Ormond St Hosp Children NHS Fdn Trust, London, England. [Di Biagio, Antonio] Univ Genoa, Infect Dis Unit, IRCCS San Martino Univ Hosp IST, Genoa, Italy. [Giacomet, Vania] L Sacco Univ Hosp, Dept Paediat, Milan, Italy. [Vibeke, Rosenfeldt] Hvidovre Univ Hosp, Dept Paediat, Copenhagen, Denmark. [de Sousa Marques, Heloisa Helena] Univ Sao Paulo, Fac Med, Hosp Clin, Inst Crianca, Sao Paulo, Brazil. [Salo, Eeva] Univ Helsinki, Cent Hosp, Childrens Hosp, Helsinki, Finland. [Salo, Eeva] Univ Helsinki, Helsinki, Finland. [Volokha, Alla] Children Ctr Clin Immunol, Kiev, Ukraine. [Scherpbier, Henriette J.] Emma Childrens Hosp, Dept Pediat Haematol Immunol & Infect Dis, Acad Med Ctr, Amsterdam, Netherlands. [Niehues, Tim] Helios Clin Krefeld, Dept Pediat, Krefeld, Germany. [Levy, Jack] St Pierre Univ Hosp, Brussels, Belgium. [Marczynska, Magdalena] Med Univ Warsaw, Pediat Dept Infect Dis, Warsaw, Poland. [Mardarescu, Mariana] Prof Dr Matei Bal Natl Inst Infect Dis, Dept Paediat Immunodepress, Bucharest, Romania. [Reliquet, Veronique] CHU Nantes, Dept Infect Dis, F-44035 Nantes 01, France. [Giaquinto, Carlo] Univ Padua, Dept Paediat, Padua, Italy. EM emma_m@hotmail.it NR 0 TC 0 Z9 0 U1 1 U2 6 PU INT AIDS SOCIETY PI GENEVA PA AVENUE DE FRANCE 23, GENEVA, 1202, SWITZERLAND SN 1758-2652 J9 J INT AIDS SOC JI J. Int. AIDS Soc. PD JUL PY 2015 VL 18 SU 4 MA WEAD0204 DI 10.7448/IAS.18.5.20414 PG 1 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA CN8FS UT WOS:000358675700129 ER PT J AU Prasitsuebsai, W Teeraananchai, S Truong, KH Ananworanich, J Do, VC Van Nguyen, L Kosalaraksa, P Kurniati, N Sudjaritruk, T Chokephaibulkit, K Singtoroj, T Kerr, SJ Sohn, AH AF Prasitsuebsai, Wasana Teeraananchai, Sirinya Truong, Khanh Huu Ananworanich, Jintanat Do, Viet Chau Van Nguyen, Lam Kosalaraksa, Pope Kurniati, Nia Sudjaritruk, Tavitiya Chokephaibulkit, Kulkanya Singtoroj, Thida Kerr, Stephen J. Sohn, Annette H. CA TASER-Pediat Study TI Treatment and resistance outcomes of Asian children on second-line antiretroviral therapy SO JOURNAL OF THE INTERNATIONAL AIDS SOCIETY LA English DT Meeting Abstract C1 [Prasitsuebsai, Wasana; Teeraananchai, Sirinya; Kerr, Stephen J.] HIV NAT, Thai Red Cross AIDS Res Ctr, Bangkok, Thailand. [Truong, Khanh Huu] Childrens Hosp 1, Ho Chi Minh City, Vietnam. [Ananworanich, Jintanat] HIV NAT, SEARCH, Thai Red Cross AIDS Res Ctr, Bangkok, Thailand. [Ananworanich, Jintanat] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Ananworanich, Jintanat] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Do, Viet Chau] Childrens Hosp 2, Ho Chi Minh City, Vietnam. [Van Nguyen, Lam] Natl Hosp Pediat, Hanoi, Vietnam. [Kosalaraksa, Pope] Khon Kaen Univ, Dept Pediat, Div Infect Dis, Khon Kaen, Thailand. [Kurniati, Nia] Cipto Mangunkusumo Gen Hosp, Jakarta, Indonesia. [Sudjaritruk, Tavitiya] Chiang Mai Univ, Fac Med, Chiang Mai 50000, Thailand. [Sudjaritruk, Tavitiya] Chiang Mai Univ, Res Inst Hlth Sci, Chiang Mai 50000, Thailand. [Chokephaibulkit, Kulkanya; Sohn, Annette H.] Mahidol Univ, Siriraj Hosp, Fac Med, Bangkok 10700, Thailand. [Singtoroj, Thida] Fdn AIDS Res, TREAT Asia amfAR, Bangkok, Thailand. [Kerr, Stephen J.] AIGHD, Amsterdam, Netherlands. EM annette.sohn@amfar.org NR 0 TC 0 Z9 0 U1 0 U2 3 PU INT AIDS SOCIETY PI GENEVA PA AVENUE DE FRANCE 23, GENEVA, 1202, SWITZERLAND SN 1758-2652 J9 J INT AIDS SOC JI J. Int. AIDS Soc. PD JUL PY 2015 VL 18 SU 4 MA MOAB0105 DI 10.7448/IAS.18.5.20332 PG 2 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA CN8FS UT WOS:000358675700017 ER PT J AU Prentice, H Tomaras, G Geraghty, D Apps, R Fong, YY Ehrenberg, P Rolland, M Kijak, G Nelson, W Decamp, A Shen, XY Yates, N Zolla-Pazner, S Nitayaphan, S Rerks-Ngarm, S Pitisuttithum, P Ferrari, G Montefiori, D McElrath, J Bailer, R Koup, R O'Connell, R Robb, M Michael, N Kim, J Thomas, R AF Prentice, Heather Tomaras, Georgia Geraghty, Daniel Apps, Richard Fong, Youyi Ehrenberg, Philip Rolland, Morgane Kijak, Gustavo Nelson, Wyatt Decamp, Allan Shen, Xiaoying Yates, Nicole Zolla-Pazner, Susan Nitayaphan, Sorachai Rerks-Ngarm, Supachai Pitisuttithum, Punnee Ferrari, Guido Montefiori, David McElrath, Juliana Bailer, Robert Koup, Richard O'Connell, Robert Robb, Merlin Michael, Nelson Kim, Jerome Thomas, Rasmi TI HIV-1-specific IgG antibody levels correlate with the presence of a specific HLA class II allele to impact acquisition and vaccine efficacy SO JOURNAL OF THE INTERNATIONAL AIDS SOCIETY LA English DT Meeting Abstract C1 [Prentice, Heather; Ehrenberg, Philip; Rolland, Morgane; Kijak, Gustavo; Robb, Merlin; Michael, Nelson; Kim, Jerome; Thomas, Rasmi] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Tomaras, Georgia; Shen, Xiaoying; Yates, Nicole; Ferrari, Guido; Montefiori, David] Duke Univ, Sch Med, Durham, NC 27706 USA. [Geraghty, Daniel; Fong, Youyi; Nelson, Wyatt; Decamp, Allan; McElrath, Juliana] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Apps, Richard] Leidos Inc, Frederick Natl Lab Canc Res, Frederick, MD USA. [Zolla-Pazner, Susan] NYU, Sch Med, New York, NY USA. [Nitayaphan, Sorachai; O'Connell, Robert] AFRIMS, Bangkok, Thailand. [Rerks-Ngarm, Supachai] Minist Publ Hlth, Nonthaburi, Thailand. [Pitisuttithum, Punnee] Mahidol Univ, Bangkok 10700, Thailand. [Bailer, Robert; Koup, Richard] NIH, Vaccine Res Ctr, Bethesda, MD 20892 USA. EM rthomas@hivresearch.org RI Tomaras, Georgia/J-5041-2016 NR 0 TC 0 Z9 0 U1 0 U2 3 PU INT AIDS SOCIETY PI GENEVA PA AVENUE DE FRANCE 23, GENEVA, 1202, SWITZERLAND SN 1758-2652 J9 J INT AIDS SOC JI J. Int. AIDS Soc. PD JUL PY 2015 VL 18 SU 4 MA TUAA0106LB DI 10.7448/IAS.18.5.20541 PG 1 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA CN8FS UT WOS:000358675700052 ER PT J AU Wang, LS Shi, W Joyce, MG Modjarrad, K Zhang, Y Leung, K Lees, CR Zhou, TQ Yassine, HM Kanekiyo, M Yang, ZY Chen, XJ Becker, MM Freeman, M Vogel, L Johnson, JC Olinger, G Todd, JP Bagci, U Solomon, J Mollura, DJ Hensley, L Jahrling, P Denison, MR Rao, SS Subbarao, K Kwong, PD Mascola, JR Kong, WP Graham, BS AF Wang, Lingshu Shi, Wei Joyce, M. Gordon Modjarrad, Kayvon Zhang, Yi Leung, Kwanyee Lees, Christopher R. Zhou, Tongqing Yassine, Hadi M. Kanekiyo, Masaru Yang, Zhi-yong Chen, Xuejun Becker, Michelle M. Freeman, Megan Vogel, Leatrice Johnson, Joshua C. Olinger, Gene Todd, John P. Bagci, Ulas Solomon, Jeffrey Mollura, Daniel J. Hensley, Lisa Jahrling, Peter Denison, Mark R. Rao, Srinivas S. Subbarao, Kanta Kwong, Peter D. Mascola, John R. Kong, Wing-Pui Graham, Barney S. TI Evaluation of candidate vaccine approaches for MERS-CoV SO NATURE COMMUNICATIONS LA English DT Article ID RESPIRATORY SYNDROME CORONAVIRUS; RECEPTOR-BINDING DOMAIN; HUMAN MONOCLONAL-ANTIBODIES; SPIKE PROTEIN; IMMUNE-RESPONSES; NEUTRALIZING ANTIBODIES; PROTECTIVE IMMUNITY; RIBI ADJUVANT; SAUDI-ARABIA; DNA VACCINES AB The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) as a cause of severe respiratory disease highlights the need for effective approaches to CoV vaccine development. Efforts focused solely on the receptor-binding domain (RBD) of the viral Spike (S) glycoprotein may not optimize neutralizing antibody (NAb) responses. Here we show that immunogens based on full-length S DNA and S1 subunit protein elicit robust serumneutralizing activity against several MERS-CoV strains in mice and non-human primates. Serological analysis and isolation of murine monoclonal antibodies revealed that immunization elicits NAbs to RBD and, non-RBD portions of S1 and S2 subunit. Multiple neutralization mechanisms were demonstrated by solving the atomic structure of a NAb-RBD complex, through sequencing of neutralization escape viruses and by constructing MERS-CoV S variants for serological assays. Immunization of rhesus macaques confers protection against MERS-CoV-induced radiographic pneumonia, as assessed using computerized tomography, supporting this strategy as a promising approach for MERS-CoV vaccine development. C1 [Wang, Lingshu; Shi, Wei; Joyce, M. Gordon; Modjarrad, Kayvon; Zhang, Yi; Leung, Kwanyee; Lees, Christopher R.; Zhou, Tongqing; Yassine, Hadi M.; Kanekiyo, Masaru; Yang, Zhi-yong; Chen, Xuejun; Todd, John P.; Rao, Srinivas S.; Kwong, Peter D.; Mascola, John R.; Kong, Wing-Pui; Graham, Barney S.] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA. [Modjarrad, Kayvon] US Mil HIV Res Program, Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Modjarrad, Kayvon] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD 20817 USA. [Yang, Zhi-yong] Sanofi Aventis, Cambridge, MA 02139 USA. [Becker, Michelle M.; Freeman, Megan; Denison, Mark R.] Vanderbilt Univ, Med Ctr, Dept Pediat, Nashville, TN 37232 USA. [Vogel, Leatrice; Subbarao, Kanta] NIAID, Emerging Resp Viruses Sect, Infect Dis Lab, NIH, Bethesda, MD 20892 USA. [Johnson, Joshua C.; Olinger, Gene; Hensley, Lisa; Jahrling, Peter] NIAID, Integrated Res Facil, NIH, Frederick, MD 21702 USA. [Bagci, Ulas; Solomon, Jeffrey; Mollura, Daniel J.] NIH, Ctr Infect Dis Imaging, Dept Radiol & Imaging Sci, Bethesda, MD 20892 USA. [Bagci, Ulas] Univ Cent Florida, CRCV, Orlando, FL 32816 USA. [Denison, Mark R.] Vanderbilt Univ, Dept Pathol Microbiol & Immunol, Med Ctr, Nashville, TN 37232 USA. RP Kong, WP (reprint author), NIAID, Vaccine Res Ctr, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA. EM wkong@niaid.nih.gov; bgraham@nih.gov RI Zhou, Tongqing/A-6880-2010; OI Zhou, Tongqing/0000-0002-3935-4637; Bagci, Ulas/0000-0001-7379-6829 FU Intramural Research Program of the Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH; US Department of Energy, Basic Energy Sciences, Office of Science [W-31-109-Eng-38]; [RO1-AI-108197] FX We thank members of the Viral Pathogenesis and Virology Laboratories as well as the Structural Biology and Structural Bioinformatics Sections at the Vaccine Research Center for insightful comments and helpful discussions. We also thank Brenda Hartman and Jonathon Stuckey for their assistance in preparing the figures. The data presented in this manuscript are tabulated in the main paper and the Supplementary Materials. Atomic coordinates and structure factors of the reported crystal structures have been deposited in the Protein Data Bank under accession codes 4ZPT, 4ZPV and 4ZPW. This work was supported by the Intramural Research Program of the Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH. Use of sector 22 (SER-CAT) at the Advanced Photon Source was supported by the US Department of Energy, Basic Energy Sciences, Office of Science, under contract number W-31-109-Eng-38. M.R.D, and M.M.B. were supported by RO1-AI-108197. Research was conducted in compliance with the Animal Welfare Act and other federal statutes and regulations relating to animals and experiments involving animals and adheres to principles stated in the Guide for the Care and Use of Laboratory Animals, NRC Publication, 2011 edition. NR 54 TC 20 Z9 23 U1 2 U2 6 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2041-1723 J9 NAT COMMUN JI Nat. Commun. PD JUL PY 2015 VL 6 AR 7712 DI 10.1038/ncomms8712 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CO0RA UT WOS:000358858500018 PM 26218507 ER PT J AU Herrera, RA AF Herrera, Ricardo A. TI Becoming Men of Some Consequence: Youth and Military Service in the Revolutionary War. SO WILLIAM AND MARY QUARTERLY LA English DT Book Review C1 [Herrera, Ricardo A.] US Army, Sch Adv Mil Studies, Ocala, FL 34470 USA. RP Herrera, RA (reprint author), US Army, Sch Adv Mil Studies, Ocala, FL 34470 USA. NR 10 TC 0 Z9 0 U1 0 U2 0 PU INST EARLY AMER HIST CULT PI WILLIAMSBURG PA BOX 220, WILLIAMSBURG, VA 23187 USA SN 0043-5597 J9 WILLIAM MARY QUART JI William Mary Q. PD JUL PY 2015 VL 72 IS 3 BP 557 EP 560 DI 10.5309/willmaryquar.72.3.0557 PG 4 WC History SC History GA CN9ZN UT WOS:000358809800020 ER PT J AU Ward, CL Ji, L Corona, BT AF Ward, Catherine L. Ji, Lisa Corona, Benjamin T. TI An Autologous Muscle Tissue Expansion Approach for the Treatment of Volumetric Muscle Loss SO BIORESEARCH OPEN ACCESS LA English DT Article DE physiology; tissue engineering; skeletal muscle; injury ID MINCED SKELETAL-MUSCLE; LOSS INJURY; EXTRACELLULAR-MATRIX; STEM-CELLS; MACROPHAGE PHENOTYPE; FUNCTIONAL DEFICITS; SATELLITE CELLS; LUMBAR FUSIONS; DEFECT MODEL; MURINE MODEL AB Volumetric muscle loss (VML) is a hallmark of orthopedic trauma with no current standard of care. As a potential therapy for some VML indications, autologous minced muscle grafts (1 mm(3) pieces of muscle) are effective in promoting remarkable de novo fiber regeneration. But they require ample donor muscle tissue and therefore may be limited in their application for large clinical VML. Here, we tested the hypothesis that autologous minced grafts may be volume expanded in a collagen hydrogel, allowing for the use of lesser autologous muscle while maintaining regenerative and functional efficacy. The results of the study indicate that 50% (but not 75%) less minced graft tissue suspended in a collagen hydrogel promoted a functional improvement similar to that of a 100% minced graft repair. However, approximately half of the number of fibers regenerated de novo with 50% graft repair. Moreover, the fibers that regenerated had a smaller cross-sectional area. These findings support the concept of using autologous minced grafts for the regeneration of muscle tissue after VML, but indicate the need to identify optimal carrier materials for expansion. C1 [Ward, Catherine L.; Ji, Lisa; Corona, Benjamin T.] US Army, Inst Surg Res, Extrem Trauma & Regenerat Med, Ft Sam Houston, TX 78234 USA. RP Corona, BT (reprint author), US Army, Inst Surg Res, Extrem Trauma & Regenerat Med, 3698 Chambers Pass,Bldg 3611, Ft Sam Houston, TX 78234 USA. EM benjamin.t.corona.vol@mail.mil NR 48 TC 4 Z9 4 U1 0 U2 3 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 2164-7844 EI 2164-7860 J9 BIORESEARCH OPEN ACC JI BioResearch Open Access PD JUL PY 2015 VL 4 IS 1 BP 198 EP 208 DI 10.1089/biores.2015.0009 PG 11 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA CL9QD UT WOS:000357312300019 PM 26309796 ER PT J AU Zaidi, SAR Afzal, A Hafeez, M Ghogho, M McLernon, DC Swami, A AF Zaidi, Syed Ali Raza Afzal, Asma Hafeez, Maryam Ghogho, Mounir McLernon, Desmond C. Swami, Ananthram TI Solar Energy Empowered 5G Cognitive Metro-Cellular Networks SO IEEE COMMUNICATIONS MAGAZINE LA English DT Article AB Harvesting energy from natural (solar, wind, vibration, etc.) and synthesized (microwave power transfer) sources is envisioned as a key enabler for realizing green wireless networks. Energy efficient scheduling is one of the prime objectives in emerging cognitive radio platforms. To that end, in this article we present a comprehensive framework to characterize the performance of a cognitive metro-cellular network empowered by solar energy harvesting. The proposed model allows designers to capture both the spatial and temporal dynamics of the energy field and the mobile user traffic. A new definition for the "energy outage probability" metric, which characterizes the self-sustainable operation of the base stations under energy harvesting, is proposed, and the process for quantifying is described with the help of a case study for various UK cities. It is shown that the energy outage probability is strongly coupled with the path-loss exponent, required quality of service, and base station and user density. Moreover, the energy outage probability varies both on a daily and yearly basis depending on the solar geometry. It is observed that even in winter, BSs can run for three to six hours without any purchase of energy from the power grid by harvesting instantaneous energy. C1 [Zaidi, Syed Ali Raza; Afzal, Asma; Hafeez, Maryam; Ghogho, Mounir; McLernon, Desmond C.] Univ Leeds, Leeds LS2 9JT, W Yorkshire, England. [Swami, Ananthram] US Army Res Lab, Adelphi, MD USA. [Ghogho, Mounir] Int Univ Rabat, Rabat, Morocco. RP Zaidi, SAR (reprint author), Univ Leeds, Leeds LS2 9JT, W Yorkshire, England. EM s.a.zaidi@leeds.ac.uk; elaaf@leeds.ac.uk; elmh@leeds.ac.uk; m.ghogho@leeds.ac.uk; d.c.mclernon@leeds.ac.uk; a.swami@ieee.org FU U.S. Army Research Labortatory [W911NF-13-1-0216] FX This work was supported by the U.S. Army Research Labortatory under Grant W911NF-13-1-0216. NR 9 TC 1 Z9 1 U1 1 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0163-6804 EI 1558-1896 J9 IEEE COMMUN MAG JI IEEE Commun. Mag. PD JUL PY 2015 VL 53 IS 7 BP 70 EP 77 PG 8 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA CN6KU UT WOS:000358544500011 ER PT J AU Kierzewski, IM Boteler, L Bedair, SS Meyer, CD Hanrahan, BM Lazarus, N AF Kierzewski, Iain M. Boteler, Lauren Bedair, Sarah S. Meyer, Christopher D. Hanrahan, Brendan M. Lazarus, Nathan TI Electroplated Copper for Heterogeneous Die Integration SO IEEE TRANSACTIONS ON COMPONENTS PACKAGING AND MANUFACTURING TECHNOLOGY LA English DT Article DE Copper; multichip module; through-silicon vias (TSVs); wafer scale integration ID THROUGH-SILICON VIAS; WAFER AB This paper introduces a heterogeneous die integration process using electroplated copper to mount a bare die into a silicon handling wafer while simultaneously forming vertical, through-wafer vias. Deep reactive-ion etching is used to form openings in the handling wafer allowing the die to be flush-mounted for minimal device thickness. The backsides of the support wafer and die are coated by copper sputtering and electroplating, which physically secures the die in place. Electrical isolation is achieved through passivation of the silicon handle wafer sidewalls before copper electroplating. Wet thermal oxide growth was chosen over plasma-enhanced chemical vapor deposition as the sidewall passivation technique, as wet thermal oxide was found to yield superior coverage and uniformity. Topside interconnects were realized using a previously established thick-film copper metallization process. A 3 x 3 die array was successfully produced and tested for die-to-die connectivity. Thermal modeling of the fabricated devices showed that power densities up to 1 W/cm(2) could be accommodated while keeping the maximum temperature below 85 degrees C. C1 [Kierzewski, Iain M.] Adelphi Lab Ctr, Gen Tech Serv Inc, Army Res Lab, Adelphi, MD 20783 USA. [Boteler, Lauren; Bedair, Sarah S.; Meyer, Christopher D.; Hanrahan, Brendan M.; Lazarus, Nathan] Adelphi Lab Ctr, US Army Res Lab, Adelphi, MD 20783 USA. RP Kierzewski, IM (reprint author), Adelphi Lab Ctr, Gen Tech Serv Inc, Army Res Lab, Adelphi, MD 20783 USA. EM iain.m.kierzewski.ctr@mail.mil; lauren.m.boteler.civ@mail.mil; sarah.s.bedair.civ@mail.mil; christopher.d.meyer1.civ@mail.mil; brendan.m.hanrahan.civ@mail.mil; nathan.lazarus2.civ@mail.mil NR 23 TC 0 Z9 0 U1 1 U2 7 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 2156-3950 EI 2156-3985 J9 IEEE T COMP PACK MAN JI IEEE Trans. Compon. Pack. Manuf. Technol. PD JUL PY 2015 VL 5 IS 7 BP 895 EP 901 DI 10.1109/TCPMT.2015.2444814 PG 7 WC Engineering, Manufacturing; Engineering, Electrical & Electronic; Materials Science, Multidisciplinary SC Engineering; Materials Science GA CN5TX UT WOS:000358494900004 ER PT J AU Bastian, ND McMurry, P Fulton, LV Griffin, PM Cui, SS Hanson, T Srinivas, S AF Bastian, Nathaniel D. McMurry, Pat Fulton, Lawrence V. Griffin, Paul M. Cui, Shisheng Hanson, Thor Srinivas, Sharan TI The AMEDD Uses Goal Programming to Optimize Workforce Planning Decisions SO INTERFACES LA English DT Article DE workforce planning; mixed-integer linear programming; stochastic optimization; goal programming; multiple-criteria decision making; military medicine ID SYSTEM; MODELS AB The mission of the Army Medical Department (AMEDD) is to provide medical and healthcare delivery for the U.S. Army. Given the large number of medical specialties in the AMEDD, determining the appropriate number of hires and promotions for each medical specialty is a complex task. The AMEDD Personnel Proponency Directorate (APPD) previously used a manual approach to project the number of hires, promotions, and personnel inventory for each medical specialty across the AMEDD to support a 30-year life cycle. As a means of decision support to APPD, we proffer the objective force model (OFM) to optimize AMEDD workforce planning. We also employ a discrete-event simulation model to verify and validate the results. In this paper, we describe the OFM applied to the Medical Specialist Corps, one of the six officer corps in the AMEDD. The OFM permits better transparency of personnel for senior AMEDD decision makers, whereas effectively projecting the optimal number of officers to meet the demands of the current workforce structure. The OFM provides tremendous value to APPD in terms of time, requiring only seconds to solve rather than months; this enables APPD to conduct quick what-if analyses for decision support, which was impossible to do manually. C1 [Bastian, Nathaniel D.] Penn State Univ, Dept Ind & Mfg Engn, Ctr Integrated Healthcare Delivery Syst, University Pk, PA 16802 USA. [Bastian, Nathaniel D.] US Army Med Dept Ctr & Sch, Ctr AMEDD Strateg Studies, Ft Sam Houston, TX 78234 USA. [McMurry, Pat] US Army Med Dept Ctr & Sch, AMEDD Personnel Proponency Directorate, Ft Sam Houston, TX 78234 USA. [Fulton, Lawrence V.] Texas Tech Univ, Ctr Healthcare Innovat Educ & Res, Rawls Coll Business Adm, Lubbock, TX 79410 USA. [Griffin, Paul M.] Georgia Inst Technol, H Milton Stewart Sch Ind & Syst Engn, Atlanta, GA 30332 USA. [Cui, Shisheng; Hanson, Thor; Srinivas, Sharan] Penn State Univ, Dept Ind & Mfg Engn, University Pk, PA 16802 USA. RP Bastian, ND (reprint author), Penn State Univ, Dept Ind & Mfg Engn, Ctr Integrated Healthcare Delivery Syst, University Pk, PA 16802 USA. EM ndbastian@psu.edu; pat.m.mcmurry.civ@mail.mil; larry.fulton@ttu.edu; paul.griffin@isye.gatech.edu; suc256@psu.edu; tkh138@psu.edu; sus412@psu.edu OI Srinivas, Sharan/0000-0003-2066-8836 FU National Science Foundation [DGE1255832]; Seth Bonder Foundation/INFORMS Bonder Scholarship for Applied Operations Research FX Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Science Foundation, Pennsylvania State University, Texas Tech University, Georgia Institute of Technology, or United States Army. We would like to thank Michael O'Connor for his assistance at the Center for AMEDD Strategic Studies. This material is based upon work supported by the National Science Foundation [Grant DGE1255832] and the Seth Bonder Foundation/INFORMS Bonder Scholarship for Applied Operations Research. NR 25 TC 1 Z9 1 U1 2 U2 11 PU INFORMS PI CATONSVILLE PA 5521 RESEARCH PARK DR, SUITE 200, CATONSVILLE, MD 21228 USA SN 0092-2102 EI 1526-551X J9 INTERFACES JI Interfaces PD JUL-AUG PY 2015 VL 45 IS 4 BP 305 EP 324 DI 10.1287/inte.2014.0779 PG 20 WC Management; Operations Research & Management Science SC Business & Economics; Operations Research & Management Science GA CN5XD UT WOS:000358505700003 ER PT J AU Richie, D Ross, J Park, S Shires, D AF Richie, David Ross, James Park, Song Shires, Dale TI Threaded MPI programming model for the Epiphany RISC array processor SO JOURNAL OF COMPUTATIONAL SCIENCE LA English DT Article; Proceedings Paper CT 15th Annual International Conference on Computational Science (ICCS) CY JUN 01-03, 2015 CL Reykjavik Univ, Reykjavik, ICELAND SP Elsevier, Univ Amsterdam, NTU Singapore, Univ Tennessee HO Reykjavik Univ DE 2D RISC array; Threaded MPI; Adapteva Epiphany; Parallella; Energy efficiency AB The low-power Adapteva Epiphany RISC array processor offers high computational energy-efficiency and parallel scalability. However, extracting performance with a standard parallel programming model remains a great challenge. We present an effective programming model for the Epiphany architecture based on the Message Passing Interface (MPI) standard adapted for coprocessor offload. Using MPI exploits the similarities between the Epiphany architecture and a networked parallel distributed cluster. Furthermore, our approach enables codes written with MPI to execute on the RISC array processor with little modification. We present experimental results for matrix-matrix multiplication using MPI and highlight the importance of fast inter-core data transfers. Using MPI we demonstrate an on-chip performance of 9.1 GFLOPS with an efficiency of 15.3 GFLOPS/W. Threaded MPI exhibits the highest performance reported for the Epiphany architecture using a standard parallel programming model. (C) 2015 Elsevier B.V. All rights reserved. C1 [Richie, David] Brown Deer Technol, Rockville, MD 20850 USA. [Ross, James] Engility Corp, Adelphi, MD USA. [Park, Song; Shires, Dale] US Army Res Lab, Adelphi, MD USA. RP Richie, D (reprint author), Brown Deer Technol, Rockville, MD 20850 USA. EM drichie@browndeertechnology.com; james.ross@engilitycorp.com; song.j.park.civ@mail.mil; dale.r.shires.civ@mail.mil NR 20 TC 2 Z9 2 U1 0 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1877-7503 J9 J COMPUT SCI-NETH JI J. Comput. Sci. PD JUL PY 2015 VL 9 SI SI BP 94 EP 100 DI 10.1016/j.jocs.2015.04.023 PG 7 WC Computer Science, Interdisciplinary Applications; Computer Science, Theory & Methods SC Computer Science GA CN7PZ UT WOS:000358627800017 ER PT J AU Buxton, VL Ward, MP Sperry, JH AF Buxton, Valerie L. Ward, Michael P. Sperry, Jinelle H. TI Use of chorus sounds for location of breeding habitat in 2 species of anuran amphibians SO BEHAVIORAL ECOLOGY LA English DT Article DE Anaxyrus; breeding behavior; chorus sounds; conspecific attraction; Hyla ID INADVERTENT SOCIAL INFORMATION; BARKING TREEFROGS HYLA; TOAD BUFO-AMERICANUS; CONSPECIFIC-ATTRACTION; WOOD FROGS; PHONOTACTIC RESPONSES; PUBLIC INFORMATION; SEXUAL SELECTION; OVIPOSITION SITE; ADULT CHOICE AB How do frogs and toads find new breeding ponds? Using an experimental field study, we found that Cope's gray tree frogs were attracted to tree frog chorus sounds, indicating that acoustic cues facilitate orientation to new breeding ponds. American toads, however, did not exhibit attraction to toad chorus sounds, suggesting that this behavior may vary according to life-history characteristics and breeding ecology.Conspecific cues have been shown to influence habitat selection in many different species. In anurans, conspecific chorus sounds may facilitate location of new breeding ponds, but direct experimental evidence supporting this notion is lacking. We conducted an experimental field study on American toads (Anaxyrus americanus) and Cope's gray tree frogs (Hyla chrysoscelis) to determine whether toads and tree frogs use acoustic cues to find new breeding areas by broadcasting chorus sounds at artificial ponds. We found that acoustic cues were effective in attracting H. chrysoscelis to ponds; playback ponds were detected by H. chrysoscelis at significantly faster rates and had greater rates of use than control ponds. Anaxyrus americanus did not colonize ponds regardless of the presence of chorus sounds. This study provides some of the first experimental field evidence that anurans use conspecific cues to locate new breeding habitat; however, species with certain life-history traits may be more likely to exhibit this behavior. These findings may have valuable applications to amphibian conservation and management. If certain anuran species use presence of conspecifics to select habitat, managers may manipulate conspecific cues to passively translocate individuals across the landscape to target wetlands. C1 [Buxton, Valerie L.; Ward, Michael P.; Sperry, Jinelle H.] Univ Illinois, Dept Nat Resources & Environm Sci, Urbana, IL 61801 USA. [Ward, Michael P.] Univ Illinois, Illinois Nat Hist Survey, Champaign, IL 61802 USA. [Sperry, Jinelle H.] Engineer Res & Dev Ctr, Champaign, IL 61826 USA. RP Buxton, VL (reprint author), Univ Illinois, Dept Nat Resources & Environm Sci, 1102 S Goodwin Ave, Urbana, IL 61801 USA. EM vbuxton2@illinois.edu FU Construction Engineering Research Laboratory of the Engineer Research Development Center [W9132T-15-0004] FX Funding was provided by the Construction Engineering Research Laboratory of the Engineer Research Development Center (grant number W9132T-15-0004). NR 60 TC 3 Z9 3 U1 0 U2 28 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1045-2249 EI 1465-7279 J9 BEHAV ECOL JI Behav. Ecol. PD JUL-AUG PY 2015 VL 26 IS 4 BP 1111 EP 1118 DI 10.1093/beheco/arv059 PG 8 WC Behavioral Sciences; Biology; Ecology; Zoology SC Behavioral Sciences; Life Sciences & Biomedicine - Other Topics; Environmental Sciences & Ecology; Zoology GA CN1IG UT WOS:000358171600022 ER PT J AU Ledford, CJW Cafferty, LA Seehusen, DA AF Ledford, Christy J. W. Cafferty, Lauren A. Seehusen, Dean A. TI Socializing Identity Through Practice: A Mixed Methods Approach to Family Medicine Resident Perspectives on Uncertainty SO FAMILY MEDICINE LA English DT Article ID DECISION-MAKING; CARE; PHYSICIANS; HIV AB OBJECTIVE: Uncertainty is a central theme in the practice of medicine and particularly primary care. This study explored how family medicine resident physicians react to uncertainty in their practice. METHODS: This study incorporated a two-phase mixed methods approach, including semi-structured personal interviews (n=21) and longitudinal selfreport surveys (n=21) with family medicine residents. RESULTS: Qualitative analysis showed that though residents described uncertainty as an implicit part of their identity, they still developed tactics to minimize or manage uncertainty in their practice. Residents described increasing comfort with uncertainty the longer they practiced and anticipated that growth continuing throughout their careers. Quantitative surveys showed that reactions to uncertainty were more positive over time; however, the difference was not statistically significant. DISCUSSION: Qualitative and quantitative results show that as family medicine residents practice medicine their perception of uncertainty changes. To reduce uncertainty, residents use relational information-seeking strategies. From a broader view of practice, residents describe uncertainty neutrally, asserting that uncertainty is simply part of the practice of family medicine. C1 [Ledford, Christy J. W.; Cafferty, Lauren A.] Uniformed Serv Univ Hlth Sci, Dept Family Med, Bethesda, MD 20814 USA. [Seehusen, Dean A.] Eisehower Army Med Ctr, Dept Family & Community Med, Ft Gordon, GA USA. RP Ledford, CJW (reprint author), Uniformed Serv Univ Hlth Sci, Dept Family Med, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM christian.ledford@usuhs.edu NR 32 TC 1 Z9 1 U1 1 U2 1 PU SOC TEACHERS FAMILY MEDICINE PI LEAWOOD PA 11400 TOMAHAWK CREEK PARKWAY, STE 540, LEAWOOD, KS 66207 USA SN 0742-3225 EI 1938-3800 J9 FAM MED JI Fam. Med. PD JUL-AUG PY 2015 VL 47 IS 7 BP 549 EP 553 PG 5 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA CM7XF UT WOS:000357909100009 PM 26562644 ER PT J AU Muhie, S Hammamieh, R Cummings, C Yang, D Jett, M AF Muhie, S. Hammamieh, R. Cummings, C. Yang, D. Jett, M. TI Stress-caused anergy of leukocytes towards Staphylococcal enterotoxin B and exposure transcriptome signatures SO GENES AND IMMUNITY LA English DT Article ID T-CELL-RECEPTOR; CYTOKINE PRODUCTION; IMMUNE SUPPRESSION; GENE-EXPRESSION; TOXIC-SHOCK; IN-VITRO; SUPERANTIGEN; ACTIVATION; INFLAMMATION; MECHANISM AB Leucocytes from soldiers exposed to battlefield-like stress (RASP: Rangers Assessment and Selection Program) were exposed in vitro to Staphylococcal enterotoxin B (SEB). We assayed SEB-induced regulation of gene expression, both in the presence and absence of severe stress, to generate two sets of gene profiles. One set of transcripts and microRNAs were specific to post-RASP SEB exposure, and another set were signatures of SEB exposure common to both the pre-and post-RASP leucocytes. Pathways and upstream regulatory analyses indicated that the post-RASP SEB-signature transcripts were manifestation of the anergic state of post-RASP leucocytes. These were further verified using expression-based predictions of cellular processes and literature searches. Specificity of the second set of transcripts to SEB exposure was verified using machine-learning algorithms on our and four other (Gene Expression Omnibus) data sets. Cell adhesion, coagulation, hypoxia and vascular endothelial growth factor-mediated vascular leakage were SEB-specific pathways even under the background of severe stress. Hsa-miR-155-3p was the top SEB exposure predictor in our data set, and C-X-C motif chemokine ligand 9 was SEB specific in all the analyzed data sets. The SEB-signature transcripts (which also showed distinct expression signatures from Yersinia pestis and dengue virus) may serve as potential biomarkers of SEB exposure even under the background of stress. C1 [Muhie, S.] Frederick Natl Lab Canc Res, Adv Biomed Comp Ctr, Frederick, MD USA. [Hammamieh, R.; Jett, M.] US Army, Integrat Syst Biol Program, Ctr Environm Hlth Res, Frederick, MD 21702 USA. [Yang, D.] Georgetown Univ, Dept Chem, Washington, DC 20057 USA. RP Jett, M (reprint author), US Army, Integrat Syst Biol Program, Ctr Environm Hlth Res, Frederick, MD 21702 USA. EM marti.jett-tilton.civ@mail.mil FU Defense Threat Reduction Agency FX We thank Julia Scheerer and Allison Hoke for editing the manuscript and for their invaluable comments. We are grateful to The Defense Threat Reduction Agency for funding. NR 30 TC 0 Z9 0 U1 1 U2 4 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1466-4879 EI 1476-5470 J9 GENES IMMUN JI Genes Immun. PD JUL-AUG PY 2015 VL 16 IS 5 BP 330 EP 346 DI 10.1038/gene.2015.16 PG 17 WC Genetics & Heredity; Immunology SC Genetics & Heredity; Immunology GA CN4CC UT WOS:000358375500006 PM 26020283 ER PT J AU Rubal, BJ Meyers, BL Kramer, SA Hanson, MA Andrews, JM DeLorenzo, RA AF Rubal, Bernard J. Meyers, Belinda L. Kramer, Sarah A. Hanson, Margaret A. Andrews, Jared M. DeLorenzo, Robert A. TI FAT INTRAVASATION FROM INTRAOSSEOUS FLUSH AND INFUSION PROCEDURES SO PREHOSPITAL EMERGENCY CARE LA English DT Article ID TOTAL HIP-ARTHROPLASTY; RANDOMIZED CLINICAL-TRIAL; BONE-MARROW EMBOLISM; VASCULAR ACCESS; CARDIOPULMONARY-RESUSCITATION; HIGH-PRESSURE; SWINE MODEL; DEVICES; ECHOCARDIOGRAPHY; PHLEBOGRAPHY AB Study hypothesis. The primary study objective was to delineate the procedural aspects of intraosseous (JO) infusions responsible for fat intravasation by testing the hypothesis that the fat content of effluent blood increases during 10 infusions. Methods. JO cannulas were inserted into the proximal tibiae of 35 anesthetized swine (Sus scrofa, 50.1 +/- 3.5 kg) and intravasated fat was assessed using a lipophilic fluoroprobe (Nile red) and by vascular ultrasound imaging. Effluent blood bone marrow fat was assessed at baseline, during flush, and with regimens of controlled infusion pressures (73-300 mmHg) and infusion flow rates (0.3-3.0 mL per second). Fat intravasation was also assessed with JO infusions at different tibial cannulation sites and in the distal femur. In 7 animals, the lipid uptake of alveolar macrophages and lung tissue assessed for fat embolic burden using oil red 0 stain 24 hours post infusion. Additionally, bone marrow shear-strain was assessed radiographically with JO infusions. Results. Fat intravasation was observed during all 10 infusion regimens, with subclinical pulmonary fat emboli persisting 24 hours post infusion. It was noted that initial flush was a significant factor in fat intravasation, low levels of intravasation occurred with infusions <= 300 mmHg, fat intravasation and bone marrow shear-strain increased with IO infusion rates, and intravasation was influenced by carmula insertion site. Ultrasound findings suggest that echogenic particles consistent with fat emboli are carried in fast and slow venous blood flow fields. Echo reflective densities were observed to rise to the nondependent endovascular margins and coalesce in accordance with Stoke's law. In addition, ultrasound findings suggested that intravasated bone marrow fat was thrombogenic. Conclusion. Results suggest that in swine the intravasation of bone marrow fat is a common consequence of JO infusion procedures and that its magnitude is influenced by the site of cannulation and infusion forces. Although the efficacy and benefits of TO infusions for emergent care are well established, emergency care providers also should be cognizant that infusion procedures affect bone marrow fat intravasation. C1 [Rubal, Bernard J.; Andrews, Jared M.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Meyers, Belinda L.; Kramer, Sarah A.; Hanson, Margaret A.; DeLorenzo, Robert A.] US Army Inst Surg Res, Ft Sam Houston, TX USA. RP Rubal, BJ (reprint author), Brooke Army Med Ctr, Serv Cardiol, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM bernard.j.rubal.civ@mail.mil FU U.S. Army Medical Department Advanced Medical Technology Initiative (AAMTI), Telemedicine and Advanced Technology Research Center (TATRC) FX Funding for this project was provided by the U.S. Army Medical Department Advanced Medical Technology Initiative (AAMTI), Telemedicine and Advanced Technology Research Center (TATRC). NR 76 TC 0 Z9 0 U1 0 U2 3 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1090-3127 EI 1545-0066 J9 PREHOSP EMERG CARE JI Prehosp. Emerg. Care PD JUL-SEP PY 2015 VL 19 IS 3 BP 376 EP 390 DI 10.3109/10903127.2014.980475 PG 15 WC Emergency Medicine; Public, Environmental & Occupational Health SC Emergency Medicine; Public, Environmental & Occupational Health GA CN1OL UT WOS:000358189200005 PM 25495011 ER PT J AU Kragh, JF Kotwal, RS Cap, AP Aden, JK Walters, TJ Kheirabadi, BS Gerhardt, RT DeLorenzo, RA Pidcoke, HF Cancio, LC AF Kragh, John F., Jr. Kotwal, Russ S. Cap, Andrew P. Aden, James K., III Walters, Thomas J. Kheirabadi, Bijan S. Gerhardt, Robert T. DeLorenzo, Robert A. Pidcoke, Heather F. Cancio, Leopoldo C. TI PERFORMANCE OF JUNCTIONAL TOURNIQUETS IN NORMAL HUMAN VOLUNTEERS SO PREHOSPITAL EMERGENCY CARE LA English DT Article DE tourniquets; hemorrhage; resuscitation; groin; inguinal; medical device ID COMBAT CASUALTY CARE; HEMORRHAGE AB Background. Ing-uinal bleeding is a common and preventable cause of death on the battlefield. Four FDA-cleared junctional tourniquets (Combat Ready Clamp [CRoC], Abdominal Aortic and Junctional Tourniquet [AAJT], Junctional Emergency Treatment Tool [JETT], and SAM Junctional Tourniquet [SJTI) were assessed in a laboratory on volunteers in order to describe differential performance of models. Objective. To examine safety and effectiveness of junctional tourniquets in order to inform the discussions of device selection for possible fielding to military units. Methods. The experiment measured safety and effectiveness parameters over timed, repeated applications. Lower extremity pulses were measured in 10 volunteers before and after junctional tourniquet application aimed at stopping the distal pulse assessed by Doppler auscultation. Safety was determined as the absence of adverse events during the time of application. Results. The CRoC, SJT, and JETT were most effective; their effectiveness did not differ (p > 0.05). All tourniquets were applied safely and successfully in at least one instance each, but pain varied by model. Subjects assessed the CRoC as most tolerable. The CRoC and SJT were the fastest to apply. Users ranked CRoC and SJT equally as performing best. Conclusion. The CRoC and SJT were the best-performing junctional tourniquets using these methods. C1 [Kragh, John F., Jr.; Kotwal, Russ S.; Cap, Andrew P.; Aden, James K., III; Walters, Thomas J.; Kheirabadi, Bijan S.; DeLorenzo, Robert A.; Pidcoke, Heather F.; Cancio, Leopoldo C.] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX 78234 USA. [Gerhardt, Robert T.] US Army Med Dept Ctr & Sch, Med Evacuat Fus Cell, Jbsa Ft Sam Houston, TX USA. RP Kragh, JF (reprint author), US Army Inst Surg Res, 3698 Chambers Pass, Jbsa Ft Sam Houston, TX 78234 USA. EM john.f.kragh.civ@mail.mil FU USAISR; Defense Health Program [201105] FX This project was funded with internal USAISR funds and the Defense Health Program (Proposal 201105: Operational system management and post-market surveillance of hemorrhage control devices used in medical care of U.S. servicepersons in the current war). NR 13 TC 5 Z9 5 U1 0 U2 0 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1090-3127 EI 1545-0066 J9 PREHOSP EMERG CARE JI Prehosp. Emerg. Care PD JUL-SEP PY 2015 VL 19 IS 3 BP 391 EP 398 DI 10.3109/10903127.2014.980478 PG 8 WC Emergency Medicine; Public, Environmental & Occupational Health SC Emergency Medicine; Public, Environmental & Occupational Health GA CN1OL UT WOS:000358189200006 PM 25494825 ER PT J AU Shaw, AP Poret, JC Grau, HA Gilbert, RA AF Shaw, Anthony P. Poret, Jay C. Grau, Henry A., Jr. Gilbert, Robert A., Jr. TI Demonstration of the B4C/NaIO4/PTFE Delay in the U.S. Army Hand-Held Signal SO ACS SUSTAINABLE CHEMISTRY & ENGINEERING LA English DT Article DE Pyrotechnic delay; Boron carbide; Periodate; Hand-held signal; Sustainable chemistry ID PYROTECHNICS; ILLUMINANTS; PERFORMANCE; FORMULATION; OXIDANTS; FUEL AB A pyrotechnic time delay based on boron carbide has been demonstrated as a viable replacement for the perchlorate- and chromate-containing formulation currently used in U.S. Army hand-held signals. Tests involving fully assembled hand-held signal rockets were conducted to evaluate the characteristics of the B4C/NaIO4/PTFE delay system in an operational configuration. The delay times observed in such dynamic tests were substantially shorter than those expected from prior static testing, necessitating the use of very slow-burning compositions to achieve the desired 5-6 s dynamic delay time. The behavior of the system at extreme temperatures (-54 and +71 degrees C) was also evaluated, confirming its reliability and safety. Impact, friction, and electrostatic discharge tests have shown that the boron carbide-based delay is insensitive to unintended ignition. TGA/DSC analysis indicated an ignition temperature of 475 degrees C, well above the decomposition temperature of NaIO4 and above the melting points of NaIO3 and PTFE. C1 [Shaw, Anthony P.; Poret, Jay C.; Grau, Henry A., Jr.; Gilbert, Robert A., Jr.] US Army RDECOM ARDEC, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07806 USA. RP Shaw, AP (reprint author), US Army RDECOM ARDEC, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07806 USA. EM anthony.p.shaw.civ@mail.mil FU U.S. Army through the RDECOM Environmental Quality Technology Program FX Karl D. Oyler and Jessica A. Vanatta are thanked for particle size measurements. Travis Fletcher and John Dixon are thanked for conducting the dynamic rocket tests. The U.S. Army is thanked for funding this work through the RDECOM Environmental Quality Technology Program. Table of contents photo credit, caption, and identifier: Master Sgt. Scott Wagers, U.S. Air Force; a U.S. Air Force security forces Airman fires an M127 parachute signal flare October 23, 2007, during Creek Defender at U.S. Army Garrison, Baumholder, Germany; defense imagery identification number 071023-F-EF201-098. NR 32 TC 2 Z9 2 U1 1 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 2168-0485 J9 ACS SUSTAIN CHEM ENG JI ACS Sustain. Chem. Eng. PD JUL PY 2015 VL 3 IS 7 BP 1558 EP 1563 DI 10.1021/acssuschemeng.5b00254 PG 6 WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Chemical SC Chemistry; Science & Technology - Other Topics; Engineering GA CM5EE UT WOS:000357708800036 ER PT J AU Ploran, EJ Rovira, E Thompson, JC Parasuraman, R AF Ploran, Elisabeth J. Rovira, Ericka Thompson, James C. Parasuraman, Raja TI Underlying Spatial Skills to Support Navigation Through Large, Unconstrained Environments SO APPLIED COGNITIVE PSYCHOLOGY LA English DT Article ID INDIVIDUAL-DIFFERENCES; WORKING-MEMORY; PERFORMANCE; DIRECTION; SENSE; STRATEGIES; REPRESENTATIONS; PERSPECTIVE; ORIENTATION; ABILITY AB Studies of spatial navigation in real-world settings have been limited to neighborhoods, campuses, and buildings. These locations have structural components, such as roads or hallways, which may direct navigation. The current study assessed navigational skills within a large-scale forested environment that contained few pre-established paths. Participants were asked to find flags using only a map and compass; dependent variables included target-finding accuracy and efficiency. In addition, measurements of sense of direction, strategy, and working memory were taken to identify how these cognitive abilities influence performance. The results demonstrate the expected correlations between sense of direction and navigational success. An unexpected correlation between spatial working memory and navigational success was also found, which was the only significant predictor of performance when all measures were regressed together. These results suggest that studies should not forget basic cognitive abilities, which may predict success more than measures of sense of direction. Copyright (c) 2015 John Wiley & Sons, Ltd. C1 [Ploran, Elisabeth J.] Hofstra Univ, Dept Psychol, Hempstead, NY 11550 USA. [Thompson, James C.; Parasuraman, Raja] George Mason Univ, Dept Psychol, Fairfax, VA 22030 USA. [Rovira, Ericka] US Mil Acad, Dept Behav Sci & Leadership, West Point, NY USA. RP Ploran, EJ (reprint author), 135 Hofstra Univ, Hempstead, NY 11549 USA. EM elisabeth.j.ploran@hofstra.edu OI Ploran, Elisabeth/0000-0002-3803-5474 FU Office of Naval Research [N000141010198]; Office of Naval Research In-house Laboratory Independent Research (ILIR) FX This research was supported by the Office of Naval Research (N000141010198). The authors would like to thank Peter Squire for the suggestion and refinement of the specific spatial working memory paradigm included in this study, supported by the Office of Naval Research In-house Laboratory Independent Research (ILIR) to Naval Surface Warfare Center, Dahlgren Division. NR 22 TC 1 Z9 1 U1 2 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0888-4080 EI 1099-0720 J9 APPL COGNITIVE PSYCH JI Appl. Cogn. Psychol. PD JUL-AUG PY 2015 VL 29 IS 4 BP 608 EP 613 DI 10.1002/acp.3135 PG 6 WC Psychology, Experimental SC Psychology GA CM9CT UT WOS:000358004500013 ER PT J AU Hew-Butler, T Rosner, MH Fowkes-Godek, S Dugas, JP Hoffman, MD Lewis, DP Maughan, RJ Miller, KC Montain, SJ Rehrer, NJ Roberts, WO Rogers, IR Siegel, AJ Stuempfle, KJ Winger, JM Verbalis, JG AF Hew-Butler, Tamara Rosner, Mitchell H. Fowkes-Godek, Sandra Dugas, Jonathan P. Hoffman, Martin D. Lewis, Douglas P. Maughan, Ronald J. Miller, Kevin C. Montain, Scott J. Rehrer, Nancy J. Roberts, William O. Rogers, Ian R. Siegel, Arthur J. Stuempfle, Kristin J. Winger, James M. Verbalis, Joseph G. TI Statement of the Third International Exercise-Associated Hyponatremia Consensus Development Conference, Carlsbad, California, 2015 SO CLINICAL JOURNAL OF SPORT MEDICINE LA English DT Article DE EAH; exercise-associated collapse; hydration ID SERUM SODIUM CONCENTRATION; INTRAVENOUS HYPERTONIC SALINE; COLLAPSED ULTRAMARATHON RUNNERS; CANYON-NATIONAL-PARK; TOTAL-BODY WATER; CYSTIC-FIBROSIS; MARATHON RUNNERS; SYMPTOMATIC HYPONATREMIA; IRONMAN TRIATHLON; RISK-FACTORS C1 [Hew-Butler, Tamara] Oakland Univ, Exercise Sci Program, Rochester, MI 48309 USA. [Rosner, Mitchell H.] Univ Virginia Hlth Syst, Div Nephrol, Charlottesville, VA USA. [Fowkes-Godek, Sandra] W Chester Univ, Dept Sports Med, W Chester, PA 19380 USA. [Dugas, Jonathan P.] Vital Grp, Chicago, IL USA. [Hoffman, Martin D.] VA Northern Calif Hlth Care Syst, Dept Phys Med & Rehabil, Sacramento, CA USA. [Hoffman, Martin D.] Univ Calif Davis, Sacramento, CA 95817 USA. [Lewis, Douglas P.] Via Christi Hosp Wichita Inc, Family Med Residency Program, Wichita, KS USA. [Maughan, Ronald J.] Univ Loughborough, Dept Sport & Exercise Nutr, Loughborough, Leics, England. [Miller, Kevin C.] Cent Michigan Univ, Athlet Training Program, Mt Pleasant, MI 48859 USA. [Montain, Scott J.] US Army, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. [Rehrer, Nancy J.] Univ Otago, Sch Phys Educ Sport & Exercise Sci, Dunedin, New Zealand. [Roberts, William O.] Univ Minnesota, Dept Family Med & Community Hlth, Minneapolis, MN USA. [Rogers, Ian R.] St John God Murdoch Hosp, Dept Emergency Med, Perth, WA, Australia. [Rogers, Ian R.] Univ Notre Dame, Perth, WA, Australia. [Siegel, Arthur J.] Harvard Univ, Sch Med, Dept Internal Med, Boston, MA USA. [Stuempfle, Kristin J.] Gettysburg Coll, Dept Hlth Sci, Gettysburg, PA 17325 USA. [Winger, James M.] Loyola Univ, Chicago Stritch Sch Med, Dept Family Med, Chicago, IL 60611 USA. [Verbalis, Joseph G.] Georgetown Univ, Med Ctr, Dept Endocrinol & Metab, Washington, DC 20007 USA. RP Hew-Butler, T (reprint author), Oakland Univ, Sch Hlth Sci, Rochester, MI 48309 USA. EM hew@oakland.edu RI maughan, ron/G-5370-2016; OI maughan, ron/0000-0002-7642-354X; Hoffman, Martin/0000-0001-8819-5989; Roberts, William O/0000-0003-4517-4330 FU food and beverage industry FX R.J.M. has received research funding and consulting fees from the food and beverage industry. He is currently Chair of the Science Advisory Board of the European Hydration Institute. The remaining authors report no conflicts of interest. NR 189 TC 26 Z9 26 U1 0 U2 12 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1050-642X EI 1536-3724 J9 CLIN J SPORT MED JI Clin. J. Sport Med. PD JUL PY 2015 VL 25 IS 4 BP 303 EP 320 DI 10.1097/JSM.0000000000000221 PG 18 WC Orthopedics; Physiology; Sport Sciences SC Orthopedics; Physiology; Sport Sciences GA CM2EK UT WOS:000357492400002 PM 26102445 ER PT J AU Houston, JR AF Houston, J. R. TI Shoreline Response to Sea-Level Rise on the Southwest Coast of Florida SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE Coastal erosion; coastal accretion ID BRUUN RULE; SEDIMENT TRANSPORT; EROSION; RIDGES; SHELF AB The state of Florida has a unique database of shoreline position measured about every 300 m and dating back to the mid-1800s that presents an opportunity to determine the effects of sea-level rise on shoreline position. In addition to sea-level rise (Bruun rule initially assumed), data are available on the southwest coast of Florida for other factors contributing to shoreline change, including beach nourishment, inlet shoal change, and longshore sediment transport. The sum of these factors should have caused significant shoreline recession, but instead the average shoreline position of this coast was stable during the early period from the 1800s to the 1970s (prior to beach nourishment) and strongly accretive from the 1800s to the 2000s. When the Bruun rule is used, shoreline change predicted by the sum of the factors compares poorly with measured data, but it compares quite well when the Dean equilibrium concept is used. The Dean equilibrium concept says that under wave action and with sufficient available offshore sand, shorelines will advance with sea-level rise due to onshore sand transport. Long-term shoreline change data for most of the Florida east coast and the Dutch central coast also support the Dean equilibrium concept. The source of the onshore sand transport in southwest Florida is identified. Sea-level rise results in long-term shoreline advance rather than recession for shorelines with sufficient onshore sand movement from beyond closure depth to the active profile, probably during episodic storms. C1 US Army, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Houston, JR (reprint author), US Army, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM james.r.houston@usace.army.mil NR 50 TC 4 Z9 4 U1 1 U2 16 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0749-0208 EI 1551-5036 J9 J COASTAL RES JI J. Coast. Res. PD JUL PY 2015 VL 31 IS 4 BP 777 EP 789 DI 10.2112/JCOASTRES-D-14-00161.1 PG 13 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA CM9KS UT WOS:000358027900001 ER PT J AU Brutsche, KE Wang, P Rosati, JD Beck, TM AF Brutsche, Katherine E. Wang, Ping Rosati, Julie D. Beck, Tanya M. TI Evolution of a Swash Zone Berm Nourishment and Influence of Berm Elevation on the Performance of Beach-Nearshore Nourishments along Perdido Key, Florida, USA SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE Beach morphology; equilibrium beach profile; coastal morphodynamics; nearshore sediment transport; Gulf of Mexico ID WEST-CENTRAL FLORIDA; BARRIER ISLANDS; PROJECT; PROFILE; COAST AB A nourishment was placed within the swash zone along eastern Perdido Key, Florida, in 2011-2012 using maintenance-dredged material from nearby Pensacola Pass, referred to here as a "swash zone berm nourishment." The study area was divided into three sections, the swash zone berm project and two adjacent areas to the west and east, and was monitored with time series beach surveys. The performance of the 2011-2012 nourishment with a constructed berm elevation of +0.91m North American Vertical Datum 1988 (NAVD88) was compared with two previous nourishments in 1985 and 1989-1991, with +3.0 m NAVD88 and +1.2 m NAVD88 elevations, respectively. The low elevation for the 2011-2012 nourishment allowed natural overwash processes to occur frequently, which resulted in net onshore sediment transport and growth of the active berm. The swash zone berm evolved back to the natural equilibrium profile shape maintained in the study area within 8 months. The high-wave energy conditions associated with the passages of Tropical Storm Debby and Hurricane Isaac accelerated the equilibrium process. Sediment volume gain west of the project area due to longshore spreading of the nourishment occurred mostly in the trough between the shoreline and the bar, rather than on the dry beach. In terms of rate of shoreline retreat, the short 1.2-km 1985 nourishment performed the poorest with a rate of 40 m/y. The long 7.3-km 1989-1991 nourishment performed the best with a retreat rate of 11 m/y. This suggests that high berm elevations do not necessarily lead to better nourishment performance. Instead, longshore extent of a nourishment may dominate project performance. Furthermore, the very high nourishment density of 1550 m(3)/m did not improve nourishment longevity. C1 [Brutsche, Katherine E.; Rosati, Julie D.; Beck, Tanya M.] US Army Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. [Wang, Ping] Univ S Florida, Sch Geosci, Coastal Res Lab, Tampa, FL 33620 USA. RP Brutsche, KE (reprint author), US Army Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. EM Katherine.E.Brutsche@usace.army.mil FU U.S. Army Corps of Engineers' Engineering Research and Development Center, Coastal and Hydraulics Laboratory, Coastal Inlets Research Program; University of South Florida FX This study was funded by the U.S. Army Corps of Engineers' Engineering Research and Development Center, Coastal and Hydraulics Laboratory, Coastal Inlets Research Program, and the University of South Florida. We thank Jeff Giles of the USACE Mobile District for supporting the field operations and many USF Coastal Research Lab student participants for their field assistance. We are grateful to Mark Nicholas of the U.S. National Park Service for his cooperation. Permission was granted by Headquarters, U.S. Army Corps of Engineers, to publish this information. NR 41 TC 1 Z9 1 U1 1 U2 7 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0749-0208 EI 1551-5036 J9 J COASTAL RES JI J. Coast. Res. PD JUL PY 2015 VL 31 IS 4 BP 964 EP 977 DI 10.2112/JCOASTRES-D-14-00087.1 PG 14 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA CM9KS UT WOS:000358027900017 ER PT J AU Styles, R AF Styles, Richard TI Flow and Turbulence over an Oyster Reef SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE Bottom roughness; hard bottoms; oysters; Reynolds stress ID CRASSOSTREA-VIRGINICA LARVAE; STRESS; SETTLEMENT; ROUGHNESS; SHALLOW AB Simultaneous measurements of near-bed flow and turbulence were collected on opposite banks of an intertidal channel in the North Inlet/Winyah Bay National Estuary Research Reserve. One bank supported an extensive cover of oysters and the other a mixture of sand and mud. The measurements allow comparisons of flow and turbulence characteristics in a similar flow regime but widely varying roughness conditions. Near-bed velocities are higher over the sandbank and occur during the maximum flood portion of the tidal cycle. In contrast, turbulence parameters are higher over the oyster reef, resulting from the presence of the larger roughness elements. Turbulent kinetic energy and Reynolds stress components increase as a function of flow speed, consistent with equilibrium boundary layer shear flows. For some bursts, the energy spectrum exhibits a -5/3 slope, indicating a defined inertial subrange. Dissipation over the oyster bank is on the order of 10 cm(2) s(-3) during maximum flood, when the near-bed current speeds are greatest. Drag coefficient and hydraulic roughness are likewise greater over the oyster bank, with average values of C-D = 0.025 and z(0) = 0.78 cm compared with C-D = 0.004 and z(0) = 0.02 cm for the sandbank. The analysis reveals a simple roughness formula for oysters in which the physical bottom roughness is equal to 5 times the average height of the oysters. C1 US Army, Corps Engineers, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. RP Styles, R (reprint author), US Army, Corps Engineers, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. EM richard.styles@usace.army.mil FU Office of Naval Research [N00014-02-1-0972]; National Oceanographic and Atmospheric Administration [NA04NOS4190109] FX I thank Hannuman Bull for assistance in the field, Megan Schuler for help with the data analysis, and the staff of the Belle W. Baruch Institute for Marine and Coastal Sciences for use of their facilities and logistical support in the field. Funding for this work was provided by the Office of Naval Research under grant N00014-02-1-0972 and by the National Oceanographic and Atmospheric Administration under grant NA04NOS4190109. NR 24 TC 5 Z9 5 U1 5 U2 16 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0749-0208 EI 1551-5036 J9 J COASTAL RES JI J. Coast. Res. PD JUL PY 2015 VL 31 IS 4 BP 978 EP 985 DI 10.2112/JCOASTRES-D-14-00115.1 PG 8 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA CM9KS UT WOS:000358027900018 ER PT J AU Kelley, AM Ranes, BM Estrada, A Grandizio, CM AF Kelley, Amanda M. Ranes, Bethany M. Estrada, Art Grandizio, Catherine M. TI Evaluation of the Military Functional Assessment Program: Preliminary Assessment of the Construct Validity Using an Archived Database of Clinical Data SO JOURNAL OF HEAD TRAUMA REHABILITATION LA English DT Article ID TRAUMATIC BRAIN-INJURY; INVENTORY AB Background: Several important factors must be considered when deciding to return a soldier to duty after a traumatic brain injury (TBI). Premature return increases risk for not only second-impact syndrome during the acute phase but also permanent changes from repetitive concussions. Thus, there is a critical need for return-to-duty (RTD) assessment criteria that encompass the spectrum of injury and disease experienced by US soldiers, particularly TBI. Objectives: To provide evidence-based standards to eventually serve as criteria for operational competence and performance of a soldier after injury. Specifically, the relationships between clinical assessments and novel military-specific tasks were evaluated. Method: Exploratory analyses (including nonparametric tests and Spearman rank correlations) of an archived database. Participants: A total of 79 patients with TBI who participated in an RTD assessment program at a US Army rehabilitation and recovery center. Main Measures: Military Functional Assessment Program (to determine a soldier's operational competence and performance after TBI) tasks; Dizziness Handicap Inventory; Dynamic Visual Acuity (vestibular function); Sensory Organization Test (postural control); Repeatable Battery for the Assessment of Neuropsychological Status (neuropsychological screening test); Beck Depression Inventory-II; Beck Anxiety Inventory; Comprehensive Trail Making Test (visual search and sequencing); posttraumatic stress disorder checklist military version; Alcohol Use Disorders Identification Test; Epworth Sleepiness Scale; Patient Health Questionnaire; and Military Acute Concussion Evaluation. Results: Selected military operational assessment tasks correlated significantly with clinical measures of vestibular function, psychological well-being, and cognitive function. Differences on occupational therapy assessments, a concussion screening tool, and a self-report health questionnaire were seen between those who passed and those who failed the RTD assessment. Specifically, those who passed the RTD assessment scored more favorably on these clinical assessments. Conclusions: This study demonstrated convergent validity between Military Functional Assessment Program tasks and clinical assessment scores. The Military Functional Assessment Program shows promise for augmenting decision making related to RTD and soldier skills. Additional research is needed to determine the effectiveness of this program in predicting RTD success. C1 [Kelley, Amanda M.; Estrada, Art; Grandizio, Catherine M.] US Army Aeromed Res Lab, Warfighter Hlth Div, Ft Rucker, AL USA. [Ranes, Bethany M.] Oak Ridge Inst, Sci & Educ, Oak Ridge, TN USA. [Kelley, Amanda M.] Natl Highway Traff Safety Adm US, Dept Transportat, Washington, DC 20590 USA. [Grandizio, Catherine M.] Embry Riddle Aeronaut Univ, Daytona Beach, FL USA. RP Kelley, AM (reprint author), Natl Highway Traff Safety Adm US, Dept Transportat, 1200 New Jersey Ave SE, Washington, DC 20590 USA. EM amanda.kelley@dot.gov FU US Army Medical Research and Materiel Command's (USAMRMC's) Military Operational Medicine Research Program; US Department of Energy; USAMRMC FX This study was funded by the US Army Medical Research and Materiel Command's (USAMRMC's) Military Operational Medicine Research Program. This research was supported in part by an appointment to the Postgraduate Research Participation Program at the US Army Aeromedical Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the US Department of Energy and USAMRMC. NR 23 TC 0 Z9 0 U1 3 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0885-9701 EI 1550-509X J9 J HEAD TRAUMA REHAB JI J. Head Trauma Rehabil. PD JUL-AUG PY 2015 VL 30 IS 4 BP E11 EP E20 DI 10.1097/HTR.0000000000000060 PG 10 WC Clinical Neurology; Rehabilitation SC Neurosciences & Neurology; Rehabilitation GA CM8JB UT WOS:000357944800002 PM 24922040 ER PT J AU Rafuse, ES AF Rafuse, Ethan S. TI The Civil War Guerrilla: Unfolding the Black Flag in History, Memory, and Myth SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Rafuse, Ethan S.] US Army Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. RP Rafuse, ES (reprint author), US Army Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 EI 1543-7795 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 2015 VL 79 IS 3 BP 835 EP 836 PG 2 WC History SC History GA CM6ZU UT WOS:000357841000030 ER PT J AU Kardouni, JR Pidcoe, PE Shaffer, SW Finucane, SD Cheatham, SA Sousa, CO Michener, LA AF Kardouni, Joseph R. Pidcoe, Peter E. Shaffer, Scott W. Finucane, Sheryl D. Cheatham, Seth A. Sousa, Catarina O. Michener, Lori A. TI Thoracic Spine Manipulation in Individuals With Subacromial Impingement Syndrome Does Not Immediately Alter Thoracic Spine Kinematics, Thoracic Excursion, or Scapular Kinematics: A Randomized Controlled Trial SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE biomechanics; manual therapy; thrust ID CERVICOTHORACIC MOTION SEGMENT; NECK-SHOULDER PAIN; PHYSICAL-EXAMINATION; THRUST MANIPULATION; RELIABILITY; THERAPY; EXPECTATIONS; COMPLAINTS; MOBILITY; POSITION AB STUDY DESIGN: Randomized controlled trial. OBJECTIVES: To determine if thoracic spinal manipulative therapy (SMT) alters thoracic kinematics, thoracic excursion, and scapular kinematics compared to a sham SMT in individuals with subacromial impingement syndrome, and also to compare changes in patient-reported outcomes between treatment groups. BACKGROUND: Prior studies indicate that thoracic SMT can improve pain and disability in individuals with subacromial impingment syndrome. However, the mechanisms underlying these benefits are not well understood. METHODS: Participants with shoulder impingement symptoms (n = 52) were randomly assigned to receive a single session of thoracic SMT or sham SMT. Thoracic and scapular kinematics during active arm elevation and overall thoracic excursion were measured before and after the intervention. Patient-reported outcomes measured were pain (numeric pain-rating scale), function (Penn Shoulder Score), and global rating of change. RESULTS: Following the intervention, there were no significant differences in changes between groups for thoracic kinematics or excursion, scapular kinematics, and patient-reported outcomes (P>.05). Both groups showed an increase in scapular internal rotation during arm raising (mean, 0.9 degrees; 95% confidence interval [CI]: 0.3 degrees, 1.6 degrees; P =.003) and lowering (0.8 degrees; 95% CI: 0.0 degrees, 1.5 degrees; P =.041), as well as improved pain reported on the numeric pain-rating scale (1.2 points; 95% CI: 0.3, 1.8; P<.001) and function on the Penn Shoulder Score (9.1 points; 95% CI: 6.5, 11.7; P<.001). CONCLUSION: Thoracic spine extension and excursion did not change significantly following thoracic SMT. There were small but likely not clinically meaningful changes in scapular internal rotation in both groups. Patient-reported pain and function improved in both groups; however, there were no significant differences in the changes between the SMT and the sham SMT groups. Overall, patient-reported outcomes improved in both groups without meaningful changes to thoracic or scapular motion. C1 [Kardouni, Joseph R.] US Army, Environm Med Res Inst, Natick, MA 01760 USA. [Pidcoe, Peter E.; Finucane, Sheryl D.] Virginia Commonwealth Univ, Dept Phys Therapy, Richmond, VA USA. [Shaffer, Scott W.] US Army Baylor Univ Doctoral Program Phys Therapy, Ft Sam Houston, TX USA. [Cheatham, Seth A.] Virginia Commonwealth Univ, Med Ctr, Dept Orthopaed Surg, Richmond, VA USA. [Sousa, Catarina O.] Univ Fed Rio Grande do Norte, Dept Phys Therapy, BR-59072970 Natal, RN, Brazil. [Michener, Lori A.] Univ So Calif, Div Biokinesiol & Phys Therapy, Los Angeles, CA USA. RP Kardouni, JR (reprint author), US Army, Environm Med Res Inst, Mil Performance Div, 15 Kansas St,Bldg 42, Natick, MA 01760 USA. EM joseph.r.kardouni.mil@mail.mil FU Clinical and Translational Science Award from National Center for Advancing Translational Sciences [ULITR000058]; A.D. Williams Fund of the Virginia Commonwealth University FX The study protocol was approved by the Institutional Review Board of Virginia Commonwealth University. This research was supported by Clinical and Translational Science Award number ULITR000058 from the National Center for Advancing Translational Sciences and the A.D. Williams Fund of the Virginia Commonwealth University. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or reflecting the views of the National Center for Advancing Translational Sciences, National Institutes of Health, the Department of the Army, or the Department of Defense. Any citations of commercial organizations and trade names in this report do not constitute an official Department of the Army endorsement or approval of the products or services of these organizations. The authors certify that they have no affiliations with or financial involvement in any organization or entity with a direct financial interest in the subject matter or materials discussed in the article. NR 33 TC 1 Z9 1 U1 4 U2 8 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD JUL PY 2015 VL 45 IS 7 BP 527 EP 538 DI 10.2519/jospt.2015.5647 PG 12 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA CM5BG UT WOS:000357701200004 PM 25996365 ER PT J AU Rahane, AB Kumar, V Dunn, JS AF Rahane, Amol B. Kumar, Vijay Dunn, Jennifer S. TI Carbon Doping in Boron Suboxide: Structure, Energetics, and Elastic Properties SO JOURNAL OF THE AMERICAN CERAMIC SOCIETY LA English DT Article ID HIGH-TEMPERATURE SYNTHESES; SUPERHARD B6O MATERIALS; AUGMENTED-WAVE METHOD; N-O SYSTEM; HIGH-PRESSURE; ASSISTED DENSIFICATION; MECHANICAL-PROPERTIES; CRYSTAL-STRUCTURE; CARBIDE; AMORPHIZATION AB The structural, electronic, and elastic properties of pristine and carbon-doped boron suboxide (B6O) are calculated using density functional theory. The results indicate that it is energetically preferable for a single carbon atom to substitute into an oxygen site rather than a boron site. The lattice parameters and cell volume increase to relieve the residual stress created by the carbon substitution. The interstitial position is not favorable for a single atom substitution. However, if two carbon atoms substitute for two neighboring oxygen atoms, then it becomes energetically favorable to dope an interstitial oxygen, boron, or carbon atom along the C-C chain. If the interstitial dopant is either boron or carbon, a local B4C-like structure with either a C-B-C or C-C-C chain is created within the boron suboxide unit cell. The resulting structure shows improvements in the bulk modulus at the expense of the shear and Young's moduli. The moduli further improve if an additional carbon is substituted within a polar or equatorial site of the neighboring B-12 icosahedron. Based on these calculations, we conclude that carbon doping can either harden or soften B6O depending on the manner in which the substitutions are populated. Furthermore, as B6O samples are often oxygen deficient, C doping can occupy such sites and improve the elastic properties. C1 [Rahane, Amol B.; Kumar, Vijay] Dr Vijay Kumar Fdn, Gurgaon 122001, Haryana, India. [Kumar, Vijay] Shiv Nadar Univ, Sch Nat Sci, Ctr Informat, Gautam Budh Nagar 201314, Uttar Pradesh, India. [Dunn, Jennifer S.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen, MD 21085 USA. RP Kumar, V (reprint author), Dr Vijay Kumar Fdn, 1969 Sect 4, Gurgaon 122001, Haryana, India. EM kumar@vkf.in FU U.S. Army Research Laboratory; International Technology Center-Pacific FX We are grateful to J. P. Singh for all his support and discussions and for making this collaboration possible. We are thankful to Jerry LaSalvia and Bob Pavlacka for providing the experimental point of view. We acknowledge the Center for Development of Advance Computing (CDAC), Pune for providing the supercomputing facilities and the U.S. Army Research Laboratory and the International Technology Center-Pacific for funding this research. NR 59 TC 1 Z9 1 U1 2 U2 18 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-7820 EI 1551-2916 J9 J AM CERAM SOC JI J. Am. Ceram. Soc. PD JUL PY 2015 VL 98 IS 7 BP 2223 EP 2233 DI 10.1111/jace.13588 PG 11 WC Materials Science, Ceramics SC Materials Science GA CM7RT UT WOS:000357894800036 ER PT J AU Kowalski, PC Belcher, DC Keltner, NL Dowben, JS AF Kowalski, Peter C. Belcher, David C. Keltner, Norman L. Dowben, Jonathan S. TI Huntington's Disease SO PERSPECTIVES IN PSYCHIATRIC CARE LA English DT Article C1 [Belcher, David C.] US Air Force, Dept Psychiat, San Antonio, TX USA. [Keltner, Norman L.] Univ Alabama Birmingham, Sch Nursing, Birmingham, AL USA. [Dowben, Jonathan S.] Brooke Army Med Ctr, Pediat & Behav Hlth Serv, San Antonio, TX USA. EM normankeltner@gmail.com NR 8 TC 0 Z9 0 U1 1 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0031-5990 EI 1744-6163 J9 PERSPECT PSYCHIATR C JI Perspect. Psychiatr. Care PD JUL PY 2015 VL 51 IS 3 BP 157 EP 161 DI 10.1111/ppc.12121 PG 5 WC Nursing; Psychiatry SC Nursing; Psychiatry GA CM9GW UT WOS:000358016700002 PM 26010510 ER PT J AU Enquobahrie, DA Moore, A Muhie, S Tadesse, MG Lin, SL Williams, MA AF Enquobahrie, Daniel A. Moore, Amy Muhie, Seid Tadesse, Mahlet G. Lin, Shili Williams, Michelle A. TI Early Pregnancy Maternal Blood DNA Methylation in Repeat Pregnancies and Change in Gestational Diabetes Mellitus Status-A Pilot Study SO REPRODUCTIVE SCIENCES LA English DT Article DE repeat pregnancies; DNA methylation; gestational diabetes mellitus; pregnancy; peripheral blood ID GENE; DISEASE; EXPRESSION; METABOLISM; PREVENTION; SUBUNITS; SEPTINS AB Repeat pregnancies with different perinatal outcomes minimize underlying maternal genetic diversity and provide unique opportunities to investigate nongenetic risk factors and epigenetic mechanisms of pregnancy complications. We investigated gestational diabetes mellitus (GDM)-related differential DNA methylation in early pregnancy peripheral blood samples collected from women who had a change in GDM status in repeat pregnancies. Six study participants were randomly selected from among women who had 2 consecutive pregnancies, only 1 of which was complicated by GDM (case pregnancy) and the other was not (control pregnancy). Epigenome-wide DNA methylation was profiled using Illumina HumanMethylation 27 BeadChips. Differential Identification using Mixture Ensemble and false discovery rate (<10%) cutoffs were used to identify differentially methylated targets between the 2 pregnancies of each participant. Overall, 27 target sites, 17 hypomethylated (fold change [ FC] range: 0.77-0.99) and 10 hypermethylated (FC range: 1.01-1.09), were differentially methylated between GDM and control pregnancies among 5 or more study participants. Novel genes were related to identified hypomethylated (such as NDUFC1, HAPLN3, HHLA3, and RHOG) or hypermethylated sites (such as SEP11, ZAR1, and DDR). Genes related to identified sites participated in cell morphology, cellular assembly, cellular organization, cellular compromise, and cell cycle. Our findings support early pregnancy peripheral blood DNA methylation differences in repeat pregnancies with change in GDM status. Similar, larger, and repeat pregnancy studies can enhance biomarker discovery and mechanistic studies of GDM. C1 [Enquobahrie, Daniel A.] Swedish Med Ctr, Ctr Perinatal Studies, Seattle, WA 98104 USA. [Enquobahrie, Daniel A.; Moore, Amy] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA. [Muhie, Seid] Walter Reed Army Med Ctr, Washington, DC USA. [Tadesse, Mahlet G.] Georgetown Univ, Dept Math & Stat, Washington, DC USA. [Lin, Shili] Ohio State Univ, Dept Stat, Columbus, OH 43210 USA. [Williams, Michelle A.] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. RP Enquobahrie, DA (reprint author), Swedish Med Ctr, Ctr Perinatal Studies, 1124 Columbia St,Suite 750, Seattle, WA 98104 USA. EM danenq@uw.edu FU Eunice Kennedy Shriver National Institute of Child Health and Human Development [HD/HL R01-032562, HD T32-052462]; National Heart, Lung, and Blood Institute of the National Institutes of Health [HL K01-103174]; National Science Foundation [DMS-1042946]; Bursary Service Award from the Department of Biostatistics, Section on Statistical Genetics of the University of Alabama [R25GM093044] FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by grants from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD/HL R01-032562, HD T32-052462), the National Heart, Lung, and Blood Institute (HL K01-103174) of the National Institutes of Health, the National Science Foundation (DMS-1042946), as well as a Bursary Service Award from the Department of Biostatistics, Section on Statistical Genetics of the University of Alabama (R25GM093044). NR 29 TC 2 Z9 2 U1 1 U2 4 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1933-7191 EI 1933-7205 J9 REPROD SCI JI Reprod. Sci. PD JUL PY 2015 VL 22 IS 7 BP 904 EP 910 DI 10.1177/1933719115570903 PG 7 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA CN0BF UT WOS:000358076100017 PM 25676578 ER PT J AU Barstow, C Rerucha, C AF Barstow, Craig Rerucha, Caitlyn TI Evaluation of Short and Tall Stature in Children SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID IDIOPATHIC SHORT STATURE; CONSENSUS GUIDELINES; RESEARCH-SOCIETY; AGE ASSESSMENT; GROWTH; MANAGEMENT; HEIGHT; DEFICIENCY; STATEMENT; STANDARDS AB Short stature is defined as a height more than two standard deviations below the mean for age (less than the 3rd percentile). Tall stature is defined as a height more than two standard deviations above the mean for age (greater than the 97th percentile). The initial evaluation of short and tall stature should include a history and physical examination, accurate serial measurements, and determination of growth velocity, midparental height, and bone age. Common normal variants of short stature are familial short stature, constitutional delay of growth and puberty, and idiopathic short stature. Pathologic causes of short stature include chronic diseases; growth hormone deficiency; and genetic disorders, such as Turner syndrome. Tall stature has the same prevalence as short stature, but it is a much less common reason for referral to subspecialty care. Common causes of tall stature include familial tall stature, obesity, Klinefelter syndrome, Marfan syndrome, and precocious puberty. Although most children with short or tall stature have variants of normal growth, children who are more than three standard deviations from the mean for age are more likely to have underlying pathology. Evaluation for pathologic etiologies is guided by history and physical examination findings. Copyright (C) 2015 American Academy of Family Physicians. C1 [Barstow, Craig] Womack Army Med Ctr, Ft Bragg, NC 28310 USA. [Rerucha, Caitlyn] Carl R Darnall Army Med Ctr, Dept Family Med, Ft Hood, TX USA. RP Barstow, C (reprint author), Womack Army Med Ctr, 2817 Reilly Rd, Ft Bragg, NC 28310 USA. EM craig.h.barstow.mil@mail.mil NR 28 TC 1 Z9 2 U1 0 U2 3 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X EI 1532-0650 J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD JUL 1 PY 2015 VL 92 IS 1 BP 43 EP 50 PG 8 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA CM1GW UT WOS:000357430300008 PM 26132126 ER PT J AU Shaha, JS Cook, JB Song, DJ Rowles, DJ Bottoni, CR Shaha, SH Tokish, JM AF Shaha, James S. Cook, Jay B. Song, Daniel J. Rowles, Douglas J. Bottoni, Craig R. Shaha, Steven H. Tokish, John M. TI Redefining "Critical" Bone Loss in Shoulder Instability: Functional Outcomes Worsen With "Subcritical" Bone Loss SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article DE instability; glenoid; bone loss; arthroscopic ID ARTHROSCOPIC BANKART REPAIR; TRAUMATIC ANTERIOR DISLOCATIONS; 3-DIMENSIONAL COMPUTED-TOMOGRAPHY; GLENOID DEFECT; RISK-FACTORS; FOLLOW-UP; GLENOHUMERAL INSTABILITY; STABILIZATION; STABILITY; REHABILITATION AB Background: Glenoid bone loss is a common finding in association with anterior shoulder instability. This loss has been identified as a predictor of failure after operative stabilization procedures. Historically, 20% to 25% has been accepted as the critical cutoff where glenoid bone loss should be addressed in a primary procedure. Few data are available, however, on lesser, subcritical amounts of bone loss (below the 20%-25% range) on functional outcomes and failure rates after primary arthroscopic stabilization for shoulder instability. Purpose: To evaluate the effect of glenoid bone loss, especially in subcritical bone loss (below the 20%-25% range), on outcomes assessments and redislocation rates after an isolated arthroscopic Bankart repair for anterior shoulder instability. Study Design: Cohort study; Level of evidence, 3. Methods: Subjects were 72 consecutive anterior instability patients (73 shoulders) who underwent isolated anterior arthroscopic labral repair at a single military institution by 1 of 3 sports medicine fellowship-trained orthopaedic surgeons. Data were collected on demographics, the Western Ontario Shoulder Instability (WOSI) score, Single Assessment Numeric Evaluation (SANE) score, and failure rates. Failure was defined as recurrent dislocation. Glenoid bone loss was calculated via a standardized technique on preoperative imaging. The average bone loss across the group was calculated, and patients were divided into quartiles based on the percentage of glenoid bone loss. Outcomes were analyzed for the entire cohort, between the quartiles, and within each quartile. Outcomes were then further stratified between those sustaining a recurrence versus those who remained stable. Results: The mean age at surgery was 26.3 years (range, 20-42 years), and the mean follow-up was 48.3 months (range, 23-58 months). The cohort was divided into quartiles based on bone loss. Quartile 1 (n = 18) had a mean bone loss of 2.8% (range, 0%-7.1%), quartile 2 (n = 19) had 10.4% (range, 7.3%-13.5%), quartile 3 (n = 18) had 16.1% (range, 13.5%-19.8%), and quartile 4 (n = 18) had 24.5% (range, 20.0%-35.5%). The overall mean WOSI score was 756.8 (range, 0-2097). The mean WOSI score correlated with SANE scores and worsened as bone loss increased in each quartile. There were significant differences (P < .05) between quartile 1 (mean WOSI/SANE, 383.3/62.1) and quartile 2 (mean, 594.0/65.2), between quartile 2 and quartile 3 (mean, 839.5/52.0), and between quartile 3 and quartile 4 (mean, 1187.6/46.1). Additionally, between quartiles 2 and 3 (bone loss, 13.5%), the WOSI score increased to rates consistent with a poor clinical outcome. There was an overall failure rate of 12.3%. The percentage of glenoid bone loss was significantly higher among those repairs that failed versus those that remained stable (24.7% vs 12.8%, P < .01). There was no significant difference in failure rate between quartiles 1, 2, and 3, but there was a significant increase in failure (P < .05) between quartiles 1, 2, and 3 (7.3%) when compared with quartile 4 (27.8%). Notably, even when only those patients who did not sustain a recurrent dislocation were compared, bone loss was predictive of outcome as assessed by the WOSI score, with each quartile's increasing bone loss predictive of a worse functional outcome. Conclusion: While critical bone loss has yet to be defined for arthroscopic Bankart reconstruction, our data indicate that critical bone loss should be lower than the 20% to 25% threshold often cited. In our population with a high level of mandatory activity, bone loss above 13.5% led to a clinically significant decrease in WOSI scores consistent with an unacceptable outcome, even in patients who did not sustain a recurrence of their instability. C1 [Shaha, James S.; Cook, Jay B.; Song, Daniel J.; Rowles, Douglas J.; Bottoni, Craig R.; Shaha, Steven H.; Tokish, John M.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Shaha, JS (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM jshaha6@gmail.com NR 42 TC 15 Z9 15 U1 2 U2 5 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0363-5465 EI 1552-3365 J9 AM J SPORT MED JI Am. J. Sports Med. PD JUL PY 2015 VL 43 IS 7 BP 1719 EP 1725 DI 10.1177/0363546515578250 PG 7 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA CM2UG UT WOS:000357537200025 PM 25883168 ER PT J AU Thomas, SJ Aldstadt, J Jarman, RG Buddhari, D Yoon, IK Richardson, JH Ponlawat, A Iamsirithaworn, S Scott, TW Rothman, AL Gibbons, RV Lambrechts, L Endy, TP AF Thomas, Stephen J. Aldstadt, Jared Jarman, Richard G. Buddhari, Darunee Yoon, In-Kyu Richardson, Jason H. Ponlawat, Alongkot Iamsirithaworn, Sopon Scott, Thomas W. Rothman, Alan L. Gibbons, Robert V. Lambrechts, Louis Endy, Timothy P. TI Improving Dengue Virus Capture Rates in Humans and Vectors in Kamphaeng Phet Province, Thailand, Using an Enhanced Spatiotemporal Surveillance Strategy SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID PRIMARY-SCHOOL CHILDREN; AEDES-AEGYPTI; HEMORRHAGIC-FEVER; HUMAN MOVEMENT; TRANSMISSION; INFECTIONS; VILLAGES; EPIDEMIOLOGY; SEVERITY; DISEASE AB Dengue is of public health importance in tropical and sub-tropical regions. Dengue virus (DENV) transmission dynamics was studied in Kamphaeng Phet Province, Thailand, using an enhanced spatiotemporal surveillance of 93 hospitalized subjects with confirmed dengue (initiates) and associated cluster individuals (associates) with entomologic sampling. A total of 438 associates were enrolled from 208 houses with household members with a history of fever, located within a 200-m radius of an initiate case. Of 409 associates, 86(21%) had laboratory-confirmed DENV infection. A total of 63 (1.8%) of the 3,565 mosquitoes collected were dengue polymerase chain reaction positive (PCR+). There was a significant relationship between spatial proximity to the initiate case and likelihood of detecting DENV from associate cases and Aedes mosquitoes. The viral detection rate from human hosts and mosquito vectors in this study was higher than previously observed by the study team in the same geographic area using different methodologies. We propose that the sampling strategy used in this study could support surveillance of DENV transmission and vector interactions. C1 [Thomas, Stephen J.; Jarman, Richard G.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD 20910 USA. [Buddhari, Darunee] Armed Forces Res Inst Med Sci, US Army Med Component, Dept Virol, Bangkok 10400, Thailand. [Aldstadt, Jared] SUNY Buffalo, Dept Geog, Buffalo, NY 14260 USA. Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Iamsirithaworn, Sopon] Minist Publ Hlth, Dept Dis Control Sci, Bur Epidemiol, Nonthaburi, Thailand. [Scott, Thomas W.] Univ Calif Davis, Dept Entomol, Davis, CA 95616 USA. [Rothman, Alan L.] Univ Rhode Isl, Inst Immunol & Informat, Providence, RI 02908 USA. [Lambrechts, Louis] CNRS, Inst Pasteur, Insect Virus Interact Grp, Dept Genomes & Genet, Paris, France. [Endy, Timothy P.] SUNY Syracuse, Dept Infect Dis, Syracuse, NY USA. NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. [Yoon, In-Kyu; Gibbons, Robert V.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Richardson, Jason H.] Armed Forces Pest Management Board, Silver Spring, MD USA. [Richardson, Jason H.] Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD 20910 USA. [Ponlawat, Alongkot] Armed Forces Res Inst Med Sci, Entomol Branch, Bangkok 10400, Thailand. RP Thomas, SJ (reprint author), Walter Reed Army Inst Res, Viral Dis Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM stephen.j.thomas3.mil@mail.mil; geojared@buffalo.edu; richard.g.jarman.mil@mail.mil; DaruneeT@afrims.org; In-Kyu.Yoon@afrims.org; jason.h.richardson.mil@mail.mil; AlongkotP@afrims.org; iamsiri@yahoo.com; twscott@ucdavis.edu; alan_rothman@mail.uri.edu; robert.v.gibbons2.mil@mail.mil; lambrechts.louis@gmail.com; endyt@upstate.edu RI Aldstadt, Jared/A-8508-2009; Lambrechts, Louis/A-2057-2010 OI Aldstadt, Jared/0000-0001-9162-7439; Lambrechts, Louis/0000-0001-5958-2138 FU NIAID NIH HHS [P01 AI034533] NR 32 TC 2 Z9 2 U1 1 U2 6 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUL PY 2015 VL 93 IS 1 BP 24 EP 32 DI 10.4269/ajtmh.14-0242 PG 9 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA CM5YG UT WOS:000357764300007 PM 25986580 ER PT J AU Drake, DL Ousterhout, BH Johnson, JR Anderson, TL Peterman, WE Shulse, CD Hocking, DJ Lohraff, KL Harper, EB Rittenhouse, TAG Rothermel, BB Eggert, LS Semlitsch, RD AF Drake, Dana L. Ousterhout, Brittany H. Johnson, Jarrett R. Anderson, Thomas L. Peterman, William E. Shulse, Christopher D. Hocking, Daniel J. Lohraff, Kenton L. Harper, Elizabeth B. Rittenhouse, Tracy A. G. Rothermel, Betsie B. Eggert, Lori S. Semlitsch, Raymond D. TI Pond-Breeding Amphibian Community Composition in Missouri SO AMERICAN MIDLAND NATURALIST LA English DT Editorial Material ID SALAMANDERS AMBYSTOMA-ANNULATUM; PREDATION; BULLFROGS; DECLINES; FISH AB We examined pond-breeding amphibian community composition at 210 ponds in Missouri between 2002 and 2012 using drift fence, dipnet, and funnel trap data. We encountered a total of 20 pond-breeding amphibian species in the combined surveys. We also examined whether the presence of American Bullfrogs, Lithobates catesbeianus, and fish influenced these patterns of diversity. Our results indicate the presence of American Bullfrogs, fish, and their interaction influenced the community composition of amphibians at these sites but in opposite patterns. American Bullfrogs often had a positive relationship with the total number of species, total caudate species, and total anuran species, whereas fish presence was negatively associated overall with species diversity, and the presence of both American Bullfrogs and fish was negatively associated with anuran species diversity. It is important to have baseline community species composition data from wide geographical ranges so spatiotemporal changes in community structure can be noted and assessed. C1 [Drake, Dana L.; Ousterhout, Brittany H.; Anderson, Thomas L.; Peterman, William E.; Eggert, Lori S.; Semlitsch, Raymond D.] Univ Missouri, Div Biol Sci, Columbia, MO 65211 USA. [Johnson, Jarrett R.] Western Kentucky Univ, Dept Biol, Bowling Green, KY 42101 USA. [Shulse, Christopher D.] Missouri Dept Transportat, Jefferson City, MO 65102 USA. [Hocking, Daniel J.] Univ New Hampshire, Dept Nat Resources & Environm, Durham, NH 03824 USA. [Lohraff, Kenton L.] US Army, IMCOM & FLW, DPW Nat Resources Branch, Ft Leonard Wood, MO 65473 USA. [Harper, Elizabeth B.] Paul Smiths Coll, Div Nat Resource Management & Ecol, New York, NY 12970 USA. [Rittenhouse, Tracy A. G.] Univ Connecticut, Dept Nat Resources & Environm, Storrs, CT 06269 USA. [Rothermel, Betsie B.] Archbold Biol Stn, Venus, FL 33960 USA. RP Drake, DL (reprint author), Univ Missouri, Div Biol Sci, Columbia, MO 65211 USA. RI Peterman, William/H-7809-2013; OI Peterman, William/0000-0001-5229-9268; Ousterhout, Brittany/0000-0001-5303-515X NR 20 TC 0 Z9 0 U1 1 U2 7 PU AMER MIDLAND NATURALIST PI NOTRE DAME PA UNIV NOTRE DAME, BOX 369, ROOM 295 GLSC, NOTRE DAME, IN 46556 USA SN 0003-0031 EI 1938-4238 J9 AM MIDL NAT JI Am. Midl. Nat. PD JUL PY 2015 VL 174 IS 1 BP 180 EP 187 PG 8 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA CM7JY UT WOS:000357869400014 ER PT J AU Quartana, PJ Finan, PH Page, GG Smith, MT AF Quartana, Phillip J. Finan, Patrick H. Page, Gayle G. Smith, Michael T. TI Effects of insomnia disorder and knee osteoarthritis on resting and pain-evoked inflammatory markers SO BRAIN BEHAVIOR AND IMMUNITY LA English DT Article DE Osteoarthritis; Insomnia disorder; Sleep; Inflammation; Cytokines; Pain; Stress ID TEMPOROMANDIBULAR-JOINT DISORDER; NECROSIS-FACTOR-ALPHA; C-REACTIVE PROTEIN; OLDER-ADULTS; SLEEP-DEPRIVATION; PSYCHOLOGICAL STRESS; PHYSICAL PERFORMANCE; OSTEO-ARTHRITIS; SEVERITY INDEX; INTERLEUKIN-6 AB Osteoarthritis is the most prevalent arthritic condition. Systemic inflammatory cytokines appear to have an important role in the onset and maintenance of the disease. Sleep disturbances are prevalent in osteoarthritis and associated with alterations in systemic inflammatory cytokines, suggesting a common pathophysiology across these conditions. A comparative investigation of the effects of insomnia disorder and osteoarthritis on pain-evoked cytokine responses has yet to be undertaken. We examined the influence of symptomatic knee osteoarthritis and insomnia disorder on resting C-reactive protein (CRP), interleukin (IL)-6, and IL-10 levels, and pain-evoked IL-6 and IL-10 responses. Participants were N= 117 older adults (mean age = 59.7 years; 61.8% women) rigorously evaluated for knee osteoarthritis and insomnia disorder using established diagnostic guidelines. Results revealed no association of osteoarthritis or insomnia disorder with CRP. Resting IL-6 was greater in osteoarthritis participants versus those without osteoarthritis, although this association was largely attributable to BMI. IL-10 was highest among participants with osteoarthritis or insomnia disorder. Growth curve modeling revealed that participants with insomnia disorder had greater pain-evoked IL-6 responses than participants without insomnia disorder or osteoarthritis. These findings highlight the utility of laboratory pain testing methods for understanding individual differences in inflammatory cytokines. Moreover, our findings provide evidence for amplified pain-evoked pro-inflammatory cytokine reactivity among older adults with clinically diagnosed insomnia disorder, even after controlling for individual differences in BMI and age. Additional research will be required determine whether an amplified pain-related cytokine response contributes to OA, and possibly other age-related disease, associated with insomnia disorder. Published by Elsevier Inc. C1 [Quartana, Phillip J.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. [Finan, Patrick H.; Smith, Michael T.] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21218 USA. [Smith, Michael T.] Johns Hopkins Univ, Sch Med, Ctr Behav & Hlth, Baltimore, MD 21218 USA. [Page, Gayle G.] Johns Hopkins Univ, Sch Nursing, Baltimore, MD 21218 USA. RP Quartana, PJ (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM phillip.j.quartana2.civ@mail.mil FU NIH/NIDA [1K23DA035915]; NIH/NIAMS [R01 AR05487, R01 AR059410] FX This research study was supported by grants NIH/NIDA 1K23DA035915 (PHF) and NIH/NIAMS grants R01 AR05487 (MTS) and R01 AR059410 (MTS). NR 75 TC 1 Z9 1 U1 5 U2 12 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0889-1591 EI 1090-2139 J9 BRAIN BEHAV IMMUN JI Brain Behav. Immun. PD JUL PY 2015 VL 47 SI SI BP 228 EP 237 DI 10.1016/j.bbi.2014.12.010 PG 10 WC Immunology; Neurosciences SC Immunology; Neurosciences & Neurology GA CL8NM UT WOS:000357231400027 PM 25532786 ER PT J AU Hathaway, JE Rishel, JP Walsh, ME Walsh, MR Taylor, S AF Hathaway, John E. Rishel, Jeremy P. Walsh, Marianne E. Walsh, Michael R. Taylor, Susan TI Explosive particle soil surface dispersion model for detonated military munitions SO ENVIRONMENTAL MONITORING AND ASSESSMENT LA English DT Article DE Explosives; Particulate materials; Simulations AB The accumulation of high explosive mass residue from the detonation of military munitions on training ranges is of environmental concern because of its potential to contaminate the soil, surface water, and groundwater. The US Department of Defense wants to quantify, understand, and remediate high explosive mass residue loadings that might be observed on active firing ranges. Previously, efforts using various sampling methods and techniques have resulted in limited success, due in part to the complicated dispersion pattern of the explosive particle residues upon detonation. In our efforts to simulate particle dispersal for high-and low-order explosions on hypothetical firing ranges, we use experimental particle data from detonations of munitions from a 155-mm howitzer, which are common military munitions. The mass loadings resulting from these simulations provide a previously unattained level of detail to quantify the explosive residue sourceterm for use in soil and water transport models. In addition, the resulting particle placements can be used to test, validate, and optimize particle sampling methods and statistical models as applied to firing ranges. Although the presented results are for a hypothetical 155-mm howitzer firing range, the method can be used for other munition types once the explosive particle characteristics are known. C1 [Hathaway, John E.; Rishel, Jeremy P.] Pacific NW Natl Lab, Richland, WA 99352 USA. [Walsh, Marianne E.; Walsh, Michael R.; Taylor, Susan] Cold Reg Res & Engn Lab, Hanover, NH USA. RP Hathaway, JE (reprint author), Pacific NW Natl Lab, Richland, WA 99352 USA. EM john.hathaway@pnnl.gov FU Environmental Security Technology Certification Program (ESTCP) FX We would like to acknowledge the funding support of the Environmental Security Technology Certification Program (ESTCP) and the guidance of Andrea Leeson, the Environmental Restoration program manager of ESTCP. Additionally, we thank the Cold Regions Research and Engineering Laboratory and Pacific Northwest National Laboratory for their resource support. NR 13 TC 0 Z9 0 U1 1 U2 1 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0167-6369 EI 1573-2959 J9 ENVIRON MONIT ASSESS JI Environ. Monit. Assess. PD JUL PY 2015 VL 187 IS 7 AR 415 DI 10.1007/s10661-015-4652-x PG 15 WC Environmental Sciences SC Environmental Sciences & Ecology GA CM0AL UT WOS:000357340500023 PM 26050065 ER PT J AU Martin, KD Patterson, D Phisitkul, P Cameron, KL Femino, J Amendola, A AF Martin, Kevin D. Patterson, David Phisitkul, Phinit Cameron, Kenneth L. Femino, John Amendola, Annunziato TI Ankle Arthroscopy Simulation Improves Basic Skills, Anatomic Recognition, and Proficiency During Diagnostic Examination of Residents in Training SO FOOT & ANKLE INTERNATIONAL LA English DT Article DE simulation; arthroscopic education; ankle ID SHOULDER ARTHROSCOPY; PERFORMANCE; MODEL AB Background: The purpose of this study was to determine whether low-fidelity arthroscopic simulation training improves basic ankle arthroscopy performance and efficiency among orthopedic trainees. Methods: Twenty-nine orthopedic surgery trainees with varying levels of experience in ankle arthroscopy were randomized into either simulation or standard practice groups. At baseline testing, all participants performed simulator-based testing and a cadaveric diagnostic ankle arthroscopy with video recording. The simulation group subsequently received 4 one-on-one, 15-minute simulation training sessions over a 4-month period, while the standard practice group received no additional simulation training or exposure. After intervention, both groups were reevaluated with simulator testing and a second recorded cadaveric diagnostic ankle arthroscopy. Two blinded, independent experts evaluated each randomized arthroscopic performance using the 15-point checklist, Arthroscopic Surgery Skill Evaluation Tool (ASSET), and total elapsed time, and all outcome measures were compared within and between groups. Results: Baseline arthroscopic experience, simulator task performance measures, and ASSET scores were equivalent between the simulation and standard practice groups. After completion of training, the simulation group outscored the control group in total ASSET score (34.9 vs 19.6; P < .001) and checklist score (14.5 vs 8.4; P < .001) and achieved nearly expert ASSET Safety scores (4.7 vs 2.9; P < .001) on the simulator model. Cadaver testing also demonstrated significant improvements in total ASSET score (28.8 vs 16.8; P < .001), checklist score (12.6 vs 7.1; P < .001), and ASSET Safety score (3.9 vs 2.6; P < .001). Conclusion: These results demonstrate that low-fidelity ankle arthroscopy simulation training can improve basic surgical skills, efficiency of movement, and anatomic recognition. The results suggest greater patient safety during ankle arthroscopy following simulation training. Level of Evidence: Level I, prospective comparative study. C1 [Martin, Kevin D.; Patterson, David; Phisitkul, Phinit; Femino, John; Amendola, Annunziato] Univ Iowa Hosp & Clin, Univ Iowa Sports Med Ctr, Orthopaed Surg, Iowa City, IA 52242 USA. [Cameron, Kenneth L.] US Mil Acad, Keller Army Hosp, West Point, NY 10996 USA. RP Martin, KD (reprint author), Univ Iowa Hosp & Clin, Univ Iowa Sports Med Ctr, Orthopaed Surg, 200 Hawkins Dr, Iowa City, IA 52242 USA. EM Dr.Kevin.D.Martin@gmail.com OI Cameron, Kenneth/0000-0002-6276-4482 FU American Orthopaedic Foot Ankle Society; Orthopaedic Foot & Ankle Foundation FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Supported by a grant from the American Orthopaedic Foot & Ankle Society with funding from the Orthopaedic Foot & Ankle Foundation NR 16 TC 2 Z9 2 U1 0 U2 3 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1071-1007 EI 1944-7876 J9 FOOT ANKLE INT JI Foot Ankle Int. PD JUL PY 2015 VL 36 IS 7 BP 827 EP 835 DI 10.1177/1071100715576369 PG 9 WC Orthopedics SC Orthopedics GA CL9KA UT WOS:000357295900013 PM 25761850 ER PT J AU Darwish, AM Ibrahim, AA Qiu, JX Viveiros, E Hung, HA AF Darwish, Ali M. Ibrahim, Amr A. Qiu, Joe X. Viveiros, Edward Hung, H. Alfred TI A Broadband 1-to-N Power Divider/Combiner With Isolation and Reflection Cancellation SO IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES LA English DT Article DE Balanced amplifier; power combiner; power divider; Wilkinson divider ID DIVIDER; DESIGN AB A novel 1-to-broadband "i pi-wave" power divider/combiner with reflection cancellation is presented and demonstrated. The new i pi-wave structure provides reflection cancellation and output port isolation with 1-to-N (arbitrary N) signal splitting or N-to-1 summing. It has low loss due to its use of low-impedance transmission lines and provides a relative bandwidth of 50%-200%. The concept is studied theoretically and demonstrated experimentally with several 1-to-4 dividers. The divider/combiner pair provides power amplifiers with broadband operation and well-matched input/output impedances. The concept can be implemented in hybrid circuits or monolithic microwave integrated circuits (MMICs). C1 [Darwish, Ali M.; Qiu, Joe X.; Viveiros, Edward; Hung, H. Alfred] Army Res Lab, Adelphi, MD 20783 USA. [Ibrahim, Amr A.] Univ Michigan, Ann Arbor, MI 48109 USA. RP Darwish, AM (reprint author), Army Res Lab, Adelphi, MD 20783 USA. EM darwish@alum.mit.edu; amralaa87@gmail.com NR 15 TC 1 Z9 1 U1 2 U2 13 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9480 EI 1557-9670 J9 IEEE T MICROW THEORY JI IEEE Trans. Microw. Theory Tech. PD JUL PY 2015 VL 63 IS 7 BP 2253 EP 2263 DI 10.1109/TMTT.2015.2431690 PG 11 WC Engineering, Electrical & Electronic SC Engineering GA CM3YW UT WOS:000357622300018 ER PT J AU Hinson, JM Dave, S Mcmenamy, SS Dave, K Turell, MJ AF Hinson, Juanita M. Dave, Sonia Mcmenamy, Scott S. Dave, Kirti Turell, Michael J. TI Immuno-Chromatographic Wicking Assay for the Rapid Detection of Chikungunya Viral Antigens in Mosquitoes (Diptera: Culicidae) SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE wicking assay; arbovirus; rapid detection; dipstick; surveillance ID REEMERGENCE; VIRUSES AB The outbreak of disease caused by chikungunya virus (CHIKV) in 2006 and the recent spread of this virus to the Americas in 2013 indicate the potential for this virus to spread and cause significant disease. However, there are currently no accurate and reliable field-usable, diagnostic methods to provide critical, real-time information for early detection of CHIKV within the vector populations in order to implement appropriate vector control and personal protective measures. In this article, we report the ability of an immuno-chromatographic assay developed by VecTOR Test Systems Inc. to detect CHIKV in a pool of female Aedes mosquitoes containing a single CHIKV-infected mosquito. The CHIKV dipstick assay was simple to use, did not require a cold chain, and provided clear results within 1 h. It was highly specific and did not cross-react with samples spiked with a variety of other alpha, bunya, and flaviviruses. The CHIKV assay can provide real-time critical information on the presence of CHIKV in mosquitoes to public health personnel. Results from this assay will allow a rapid threat assessment and the focusing of vector control measures in high-risk areas. C1 [Hinson, Juanita M.; Mcmenamy, Scott S.] US Army, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. [Dave, Sonia; Dave, Kirti] VecTOR Test Syst Inc, Thousand Oaks, CA 91320 USA. RP Turell, MJ (reprint author), US Army, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. EM michael.j.turell.civ@mail.mil FU Department of Defense Small Business Innovation Research (DoD SBIR) [W81XWH-10-C-0041]; Military Infectious Diseases Research Program (MIDRP) [U0 312_11_WR] FX This project was funded in part by Department of Defense Small Business Innovation Research (DoD SBIR) contract W81XWH-10-C-0041 to VecTOR Test Systems, Inc. and Military Infectious Diseases Research Program (MIDRP) study U0 312_11_WR. NR 13 TC 0 Z9 0 U1 1 U2 2 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-2585 EI 1938-2928 J9 J MED ENTOMOL JI J. Med. Entomol. PD JUL PY 2015 VL 52 IS 4 BP 699 EP 704 DI 10.1093/jme/tjv047 PG 6 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA CM4XD UT WOS:000357688400021 PM 26335477 ER PT J AU Ruhl, D Camacho, M Lustik, M Cable, B AF Ruhl, Douglas Camacho, Macario Lustik, Michael Cable, Benjamin TI Head and Neck Complications after PCV7 Vaccine: Additional Considerations SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Letter ID CLINICAL-PRACTICE GUIDELINE; OTITIS-MEDIA; MANAGEMENT C1 [Ruhl, Douglas; Camacho, Macario; Cable, Benjamin] Tripler Army Med Ctr, Dept Otolaryngol Head & Neck Surg, Honolulu, HI 96859 USA. [Lustik, Michael] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. RP Ruhl, D (reprint author), Tripler Army Med Ctr, Dept Otolaryngol Head & Neck Surg, Honolulu, HI 96859 USA. OI Camacho, Macario/0000-0001-9200-9085 NR 5 TC 0 Z9 0 U1 0 U2 0 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0194-5998 EI 1097-6817 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD JUL PY 2015 VL 153 IS 1 BP 155 EP 156 DI 10.1177/0194599815583976 PG 2 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA CL9KL UT WOS:000357297000027 PM 26124466 ER PT J AU Holcombe, H Parry, NM Rick, M Brown, DE Albers, TM Refsal, KR Morris, J Kelly, R Marko, ST AF Holcombe, H. Parry, N. M. Rick, M. Brown, D. E. Albers, T. M. Refsal, K. R. Morris, J. Kelly, R. Marko, S. T. TI Hypervitaminosis D and Metastatic Calcification in a Colony of Inbred Strain 13 Guinea Pigs, Cavia porcellus SO VETERINARY PATHOLOGY LA English DT Article DE guinea pigs; vitamin D; toxicity; metastatic calcification; cholecalciferol ID SOFT TISSUE CALCIFICATION; VITAMIN-D; RENAL-FAILURE; CALCIUM; PHOSPHORUS; METABOLISM; MAGNESIUM; DIET; SPERMATOZOA; HALIPHAGIA AB A commercial diet fed to a colony of inbred strain 13 guinea pigs for approximately 6 weeks was subsequently recalled for excessive levels of vitamin D. Twenty-one of 62 animals exhibited clinical signs, including anorexia, lethargy, and poor body condition. Nine affected and 4 clinically normal animals were euthanized for further evaluation, including serum chemistry, urinalysis, and gross and/or histopathology. Macroscopic findings included white discoloration in multiple organs in 8 animals, and microscopic evaluation confirmed multiorgan mineralization in tissues from 7 animals. Serum 25-hydroxyvitamin D levels were elevated in 10 animals. Serum inorganic phosphorus and alkaline phosphatase levels were increased in all exposed animals; however, total calcium and ionized calcium levels were not significantly higher in exposed animals than in control strain 13 guinea pigs from a different institution. The data support a diagnosis of hypervitaminosis D with metastatic calcification. Following the diet recall, the remaining guinea pigs increased their food intake and regained body condition. Diagnostic testing of 8 animals euthanized approximately 3 months after returning to a normal diet demonstrated that serum parathyroid hormone remained significantly lower, and ionized calcium and ionized magnesium were significantly higher, in recovered animals compared to controls and exposed animals. These results indicate that diagnostic tests other than serum calcium are necessary for a diagnosis of hypervitaminosis D in guinea pigs. C1 [Holcombe, H.; Parry, N. M.] MIT, Div Comparat Med, Cambridge, MA 02139 USA. [Rick, M.; Refsal, K. R.] Michigan State Univ, Diagnost Ctr Populat & Anim Hlth, Lansing, MI USA. [Brown, D. E.; Morris, J.] Massachusetts Gen Hosp, Ctr Comparat Med, Boston, MA 02114 USA. [Brown, D. E.] Harvard Univ, Sch Med, Dept Pathol, Massachusetts Gen Hosp, Boston, MA 02115 USA. [Albers, T. M.] Res Models & Serv, Wilmington, MA USA. [Kelly, R.; Marko, S. T.] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Holcombe, H (reprint author), MIT, Div Comparat Med, 77 Massachusetts Ave, Cambridge, MA 02139 USA. EM hrh@mit.edu FU NIH HHS [R21 OD011193] NR 31 TC 0 Z9 0 U1 2 U2 11 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0300-9858 EI 1544-2217 J9 VET PATHOL JI Vet. Pathol. PD JUL PY 2015 VL 52 IS 4 BP 741 EP 751 DI 10.1177/0300985814551423 PG 11 WC Pathology; Veterinary Sciences SC Pathology; Veterinary Sciences GA CM2MT UT WOS:000357515400022 PM 25281651 ER PT J AU DiPasquale, DM Strangman, GE Harris, NS Muza, SR AF DiPasquale, Dana M. Strangman, Gary E. Harris, N. Stuart Muza, Stephen R. TI Hypoxia, Hypobaria, and Exercise Duration Affect Acute Mountain Sickness SO AEROSPACE MEDICINE AND HUMAN PERFORMANCE LA English DT Article DE normobaric; hypobaric; altitude; physical activity; severity; acute mountain sickness ID NORMOBARIC HYPOXIA; HIGH-ALTITUDE; VENTILATION; SATURATION; RESPONSES; HUMANS; SLEEP AB INTRODUCTION: This study simultaneously quantified the effects of normobaric hypoxia (NH), hypobaric hypoxia (HH), exercise duration, and exposure time on acute mountain sickness severity (AMS-C). METHODS: Thirty-six subjects (27.7 +/- 7.8 yr) participated in a partial repeated measures study, completing two of six conditions: normobaric normoxia (NN: 300 m/984 ft equivalent), NH or HH (PO2 = 91 mmHg; 4400 m/14,436 ft equivalent), combined with moderate intensity cycling for 10 or 60 min. Subjects completed the Environmental Symptoms Questionnaire and oxygen saturation (SpO2) was measured before, 1.5 h, 4 h, and 6.5 h into an 8-h exposure, and 1.5 h post-exposure. We fit multiple linear regression models with cluster adjusted standard errors on the exposure times using NH, HH, and long exercise as indicator variables, and AMS-C as the outcome variable. The SpO2 and pre-exposure AMS-C score were used as covariates. RESULTS: NH and HH led to substantial and progressively increasing AMS-C, but NN did not. The effect of HH on AMS-C was significantly different from NH, with AMS-C in HH being 1.6 times higher than in NH. HH led to significantly increasing AMS-C, regardless of the exercise duration, while NH only did so in combination with longer exercise. DISCUSSION: Increases in AMS-C were each independently related to NH, HH, and long duration exercise, with HH affecting AMS-C more severely. This suggests that hypobaria may affect AMS development above the level induced by hypoxia alone. This further suggests that NH and HH may not be interchangeable for studying AMS and that exercise duration may impact physiological responses. C1 [DiPasquale, Dana M.] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA. Massachusetts Gen Hosp, Div Wilderness Med, Dept Emergency Med, Boston, MA 02114 USA. Harvard Univ, Sch Med, Boston, MA USA. US Army Res Inst Environm Med, Environm Med & Mil Performance Div, Natick, MA USA. RP DiPasquale, DM (reprint author), Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA. EM dipasquale.dana@gmail.com FU DOD CDMRP program [W81-XWH1020199] FX We gratefully acknowledge the support of the DOD CDMRP program and grant W81-XWH1020199. We would also like to thank the following individuals for their assistance with this project: Andrea Gunn, Richard Goldstein, Janet Staab, Chuck Fulco, Beth Beidleman, Ingrid Sills, Vincent Forte, Marie Grunbeck, Sean Andrew, Katylin Guerriere, Myra Jones, Leslie Levine, SPC Bodunrin Shobayo, LTC James Persson, and all the USARIEM chamber operators. NR 22 TC 8 Z9 9 U1 0 U2 7 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 2375-6314 EI 2375-6322 J9 AEROSP MED HUM PERF JI Aerosp. Med.Hum. Perform. PD JUL PY 2015 VL 86 IS 7 BP 614 EP 619 DI 10.3357/AMHP.4266.2015 PG 6 WC Biophysics; Public, Environmental & Occupational Health; Medicine, Research & Experimental SC Biophysics; Public, Environmental & Occupational Health; Research & Experimental Medicine GA CM0RG UT WOS:000357385400004 PM 26102141 ER PT J AU DiPasquale, DM Strangman, GE Harris, NS Muza, SR AF DiPasquale, D. M. Strangman, G. E. Harris, N. S. Muza, S. R. TI Acute Mountain Sickness, Hypoxia, Hypobaria and Exercise Duration each Affect Heart Rate SO INTERNATIONAL JOURNAL OF SPORTS MEDICINE LA English DT Article DE altitude; normobaric; hypobaric; cardiovascular ID PULMONARY ARTERIAL BARORECEPTORS; EXHALED NITRIC-OXIDE; NORMOBARIC HYPOXIA; HIGH-ALTITUDE; PHYSIOLOGICAL-RESPONSES; SIMULATED ALTITUDE; BODY-TEMPERATURE; EXPOSURE; HUMANS; SUSCEPTIBILITY AB In this study, we quantified the changes in post-exercise resting heart rate (HRrst) associated with acute mountain sickness (AMS), and compared the effects of hypobaric hypoxia (HH) and normobaric hypoxia (NH) on HRrst. We also examined the modulating roles of exercise duration and exposure time on HRrst. Each subject participated in 2 of 6 conditions: normobaric normoxia (NN), NH, or HH (4400m altitude equivalent) combined with either 10 or 60min of moderate cycling at the beginning of an 8-h exposure. AMS was associated with a 2bpm higher HRrst than when not sick, after taking into account the ambient environment, exercise duration, and SpO(2). In addition, HRrst was elevated in both NH and HH compared to NN with HRrst being 50% higher in HH than in NH. Participating in long duration exercise led to elevated resting HRs (0.8-1.4bpm higher) compared with short exercise, while short exercise caused a progressive increase in HRrst over the exposure period in both NH and HH (0.77-1.2bpm/h of exposure). This data suggests that AMS, NH, HH, exercise duration, time of exposure, and SpO(2) have independent effects on HRrst. It further suggests that hypobaria exerts its own effect on HRrst in hypoxia. Thus NH and HH may not be interchangeable environments. C1 [DiPasquale, D. M.] Univ Pittsburgh, Dept Sports Med & Nutr, Pittsburgh, PA 15203 USA. [DiPasquale, D. M.; Strangman, G. E.] Massachusetts Gen Hosp, Psychiat, Charlestown, MA USA. [Harris, N. S.] Massachusetts Gen Hosp, Dept Emergency Med, Boston, MA 02114 USA. [DiPasquale, D. M.; Strangman, G. E.; Harris, N. S.] Harvard Univ, Sch Med, Boston, MA USA. [Muza, S. R.] US Army Res Inst Environm Med, Thermal & Mt Med Div, Natick, MA USA. RP DiPasquale, DM (reprint author), Univ Pittsburgh, Dept Sports Med & Nutr, 3830 South Water St, Pittsburgh, PA 15203 USA. EM dmd116@pitt.edu FU DOD CDMRP program; [W81-XWH1020199] FX We gratefully acknowledge the support of the DOD CDMRP program and grant W81-XWH1020199. We also thank the following individuals for their assistance: Andrea Gunn, Richard Goldstein, Janet Staab, Chuck Fulco, Beth Beidleman, Ingrid Sills, Vincent Forte, Marie Grunbeck, Sean Andrew, Katylin Guerriere and Myra Jones. Approved for public release; distribution is unlimited. The views, opinions and/or findings contained in this publication are those of the authors and should not be construed as an official Dept. of the Army position, policy or decision unless so designated by other documentation. For the protection of human subjects, the investigators adhered to policies of applicable Federal Law CFR 46. Human subjects participated in these studies after giving their free and informed consent. Investigators adhered to AR 70-25 and USAMRMC Regulation 70-25 on the use of volunteers in research. Any citations of commercial organizations and trade names in this report do not constitute an official Dept. of the Army endorsement of approval of the products or services of the organizations. NR 40 TC 6 Z9 6 U1 1 U2 8 PU GEORG THIEME VERLAG KG PI STUTTGART PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY SN 0172-4622 EI 1439-3964 J9 INT J SPORTS MED JI Int. J. Sports Med. PD JUL PY 2015 VL 36 IS 8 BP 609 EP 614 DI 10.1055/s-0034-1398623 PG 6 WC Sport Sciences SC Sport Sciences GA CL8HL UT WOS:000357215100001 PM 25837245 ER PT J AU Hoge, CW Jonas, WB AF Hoge, Charles W. Jonas, Wayne B. TI Hyperbaric Oxygen Treatment for Persistent Postconcussion Symptoms-A Placebo Effect? Reply SO JAMA INTERNAL MEDICINE LA English DT Letter ID CEREBRAL-PALSY; THERAPY; CHILDREN C1 [Hoge, Charles W.] Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Silver Spring, MD 20910 USA. [Jonas, Wayne B.] Samueli Inst, Alexandria, VA USA. RP Hoge, CW (reprint author), Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM charles.w.hoge.civ@mail.mil NR 7 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6106 EI 2168-6114 J9 JAMA INTERN MED JI JAMA Intern. Med. PD JUL PY 2015 VL 175 IS 7 BP 1241 EP 1241 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA CM3SM UT WOS:000357604400047 PM 26146915 ER PT J AU Hu, FS Yadav, SK La Scala, JJ Sadler, JM Palmese, GR AF Hu, Fengshuo Yadav, Santosh Kumar La Scala, John J. Sadler, Joshua M. Palmese, Giuseppe R. TI Preparation and Characterization of Fully Furan-Based Renewable Thermosetting Epoxy-Amine Systems SO MACROMOLECULAR CHEMISTRY AND PHYSICS LA English DT Article DE amine; epoxy; furan-based; renewable; thermoset AB Fully furan-based epoxy/amine thermosetting materials are prepared and investigated using a furanyl epoxy monomer, 2,5-bis[(2-oxiranylmethoxy)methyl]-furan (BOF), and two furanyl amine hardeners, 5,5-methylenedifurfurylamine (DFDA) and 5,5-ethylidenedifurfirylamine (CH3-DFDA). These furan-based thermosets have shown promising glass transition temperatures (62 and 69 degrees C, respectively, using tan delta) and room temperature storage moduli (approximate to 3.5 GPa). The BOF/CH3-DFDA sample is exhibited higher T-g than the BOF/DFDA system due to the presence of an additional methyl group in CH3-DFDA. Used as curing agents for DGEBA, DFDA and CH3-DFDA have shown excellent performance with resulting T(g)s well above 120 degrees C. Onset degradation temperature of the fully furan-based samples is observed around 270 degrees C with high char yields (approximate to 40 wt%) at 750 degrees C in argon. Based on their thermal and mechanical properties, the renewable fully furan-based thermosets are found suitable for coating, adhesive, and composite applications, and are therefore potential replacements for incumbent systems. C1 [Hu, Fengshuo; Yadav, Santosh Kumar; Palmese, Giuseppe R.] Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA. [La Scala, John J.; Sadler, Joshua M.] Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Palmese, GR (reprint author), Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA. EM grp27@drexel.edu FU SERDP [WP03-015, W911NF-15-2-0017, SERDP-2402]; U.S. Army Research Laboratory under the Army Materials Center of Excellence Program [W911NF-06-2-0013]; China Scholarship Council FX The authors F.H. and S.K.Y. contributed equally to this work. The authors acknowledge financial support from SERDP under Project No. WP03-015, Cooperative agreement W911NF-15-2-0017 and SERDP-2402, and the U.S. Army Research Laboratory under the Army Materials Center of Excellence Program, Contract No. W911NF-06-2-0013. Support to Fengshuo Hu from the China Scholarship Council is also acknowledged. NR 13 TC 10 Z9 10 U1 5 U2 29 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY SN 1022-1352 EI 1521-3935 J9 MACROMOL CHEM PHYS JI Macromol. Chem. Phys. PD JUL PY 2015 VL 216 IS 13 BP 1441 EP 1446 DI 10.1002/macp.201500142 PG 6 WC Polymer Science SC Polymer Science GA CL9ZC UT WOS:000357336900010 ER PT J AU Yoo, SW Motari, MG Susuki, K Prendergast, J Mountney, A Hurtado, A Schnaar, RL AF Yoo, Seung-Wan Motari, Mary G. Susuki, Keiichiro Prendergast, Jillian Mountney, Andrea Hurtado, Andres Schnaar, Ronald L. TI Sialylation regulates brain structure and function SO FASEB JOURNAL LA English DT Article DE animal models; behavior; gangliosides; myelin; oligodendrocyte precursor cells ID MYELIN-ASSOCIATED GLYCOPROTEIN; LACKING COMPLEX GANGLIOSIDES; GM3 SYNTHASE DEFICIENCY; GROWTH-FACTOR RECEPTOR; CRUCIAL ROLE; CELL-GROWTH; MICE; EXPRESSION; DIFFERENTIATION; BIOSYNTHESIS AB Every cell expresses a molecularly diverse surface glycan coat (glycocalyx) comprising its interface with its cellular environment. In vertebrates, the terminal sugars of the glycocalyx are often sialic acids, 9-carbon backbone anionic sugars implicated in intermolecular and intercellular interactions. The vertebrate brain is particularly enriched in sialic acid-containing glycolipids termed gangliosides. Human congenital disorders of ganglioside biosynthesis result in paraplegia, epilepsy, and intellectual disability. To better understand sialoglycan functions in the nervous system, we studied brain anatomy, histology, biochemistry, and behavior in mice with engineered mutations in St3gal2 and St3gal3, sialyltransferase genes responsible for terminal sialylation of gangliosides and some glycoproteins. St3gal2/3 double-null mice displayed dysmyelination marked by a 40% reduction in major myelin proteins, 30% fewer myelinated axons, a 33% decrease in myelin thickness, and molecular disruptions at nodes of Ranvier. In part, these changes may be due to dysregulation of ganglioside-mediated oligodendroglial precursor cell proliferation. Neuronal markers were also reduced up to 40%, and hippocampal neurons had smaller dendritic arbors. Young adult St3gal2/3 double-nullmice displayed impaired motor coordination, disturbed gait, and profound cognitive disability. Comparisons among sialyltransferase mutant mice provide insights into the functional roles of brain gangliosides and sialoglycoproteins consistent with related human congenital disorders. C1 [Yoo, Seung-Wan; Motari, Mary G.; Prendergast, Jillian; Schnaar, Ronald L.] Johns Hopkins Univ, Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD 21205 USA. [Hurtado, Andres] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA. [Schnaar, Ronald L.] Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA. [Susuki, Keiichiro] Baylor Coll Med, Dept Neurosci, Houston, TX 77030 USA. [Mountney, Andrea] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect & Neurorestorat Branch, Silver Spring, MD USA. [Hurtado, Andres] Kennedy Krieger, Hugo W Moser Res Inst, Int Ctr Spinal Cord Injury, Baltimore, MD USA. RP Schnaar, RL (reprint author), Johns Hopkins Univ, Sch Med, Dept Pharmacol & Mol Sci, 725 North Wolfe St, Baltimore, MD 21205 USA. EM schnaar@jhu.edu RI Schnaar, Ronald/S-8967-2016 OI Schnaar, Ronald/0000-0002-7701-5484 FU U.S. National Institutes of Health, National Institute of Neurological Disorders and Stroke [NS037096, NS057338]; U.S. National Multiple Sclerosis Society grant FX The authors thank Jamey D. Marth (University of California, Santa Barbara, Santa Barbara, CA, USA) for providing founder mice for these studies and Alison Nairn (University of Georgia, Athens, GA, USA) for expert transcript analyses. This work was supported by U.S. National Institutes of Health, National Institute of Neurological Disorders and Stroke Grants NS037096 and NS057338 (to R.L.S.) and a U.S. National Multiple Sclerosis Society grant (to Dr. Matthew N. Rasband, Department of Neuroscience, Baylor College of Medicine in support of K.S.). The views of the authors do not purport or reflect the position of the U.S. Department of the Army or the U.S. Department of Defense (para 4-3, AR 360-5). All research was conducted in compliance with the Animal Welfare Act, the Guide for the Care and Use of Laboratory Animals (U.S. National Research Council), and other federal statutes and regulations relating to animals and experiments involving animals. NR 58 TC 6 Z9 6 U1 0 U2 10 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD JUL PY 2015 VL 29 IS 7 BP 3040 EP 3053 DI 10.1096/fj.15-270983 PG 14 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA CL3OI UT WOS:000356859100031 PM 25846372 ER PT J AU Bridges, TS AF Bridges, Todd S. TI REMEMBERING DR. ROBERT (BOB) M ENGLER 1941-2015 IN MEMORIAM SO INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT LA English DT Biographical-Item C1 US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Bridges, TS (reprint author), US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. NR 1 TC 0 Z9 0 U1 0 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1551-3777 EI 1551-3793 J9 INTEGR ENVIRON ASSES JI Integr. Environ. Assess. Manag. PD JUL PY 2015 VL 11 IS 3 BP 341 EP 342 DI 10.1002/ieam.1647 PG 2 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA CL5RZ UT WOS:000357019400001 PM 26119879 ER PT J AU Bologna, M Beig, MT Svenkeson, A Grigolini, P West, BJ AF Bologna, M. Beig, M. T. Svenkeson, A. Grigolini, P. West, B. J. TI Spectral Decomposition of a Fokker-Planck Equation at Criticality SO JOURNAL OF STATISTICAL PHYSICS LA English DT Article DE Criticality; Critical slowing down; Temporal complexity; Decision making model; Stochastic linearization ID CRITICAL SLOWING-DOWN; BIFURCATION; MODEL AB The mean field for a complex network consisting of a large but finite number of random two-state elements, , has been shown to satisfy a nonlinear Langevin equation. The noise intensity is inversely proportional to . In the limiting case , the solution to the Langevin equation exhibits a transition from exponential to inverse power law relaxation as criticality is approached from above or below the critical point. When , the inverse power law is truncated by an exponential decay with rate , the evaluation of which is the main purpose of this article. An analytic/numeric approach is used to obtain the lowest-order eigenvalues in the spectral decomposition of the solution to the corresponding Fokker-Planck equation and its equivalent Schrodinger equation representation. C1 [Bologna, M.] Univ Tarapaca, Inst Alta Invest, Arica, Chile. [Beig, M. T.; Grigolini, P.] Univ N Texas, Ctr Nonlinear Sci, Denton, TX 76203 USA. [Svenkeson, A.] Army Res Lab, Adelphi, MD 20883 USA. [West, B. J.] Army Res Off, Informat Sci Directorate, Res Triangle Pk, NC 27709 USA. RP Beig, MT (reprint author), Univ N Texas, Ctr Nonlinear Sci, Denton, TX 76203 USA. EM mauroh69@libero.it; mirzatanweer@gmail.com FU FONDECYT [1120344]; ARO [W911NF-11-1-0478]; Welch [B-1577] FX MB acknowledges financial support from FONDECYT Project No. 1120344. MTB, AS and PG warmly thank ARO and Welch for their support through Grants No. W911NF-11-1-0478 and No. B-1577, respectively. NR 19 TC 2 Z9 2 U1 3 U2 9 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0022-4715 EI 1572-9613 J9 J STAT PHYS JI J. Stat. Phys. PD JUL PY 2015 VL 160 IS 2 BP 466 EP 476 DI 10.1007/s10955-015-1262-5 PG 11 WC Physics, Mathematical SC Physics GA CL3AB UT WOS:000356819400011 ER PT J AU Firoozabadi, R Alton, T Wenke, J AF Firoozabadi, Reza Alton, Timothy Wenke, Joseph TI Novel Strategies for the Diagnosis of Posttraumatic Infections in Orthopaedic Trauma Patients SO JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS LA English DT Review DE posttraumatic; infection; molecular diagnostics ID C-REACTIVE PROTEIN; ERYTHROCYTE SEDIMENTATION-RATE; FDG-PET; BIOFILM INFECTIONS; JOINT INFECTIONS; OSTEOMYELITIS; BONE; CULTURE; SCINTIGRAPHY; SENSITIVITY AB Orthopaedic infections that occur after trauma are common. Clinical examination, laboratory markers, imaging modalities, and culture and molecular technologies are used to aid the diagnosis of infection. Culture methods comprise the backbone of diagnostic systems used in hospital laboratory settings; however, several studies have questioned the ability of these techniques to adequately identify infections, particularly in cases where orthopaedic implants were used or when the presence of biofilm bacteria is suspected. Advances in imaging and molecular diagnostics can provide orthopaedic surgeons with an improved means of diagnosing and treating infections. C1 [Firoozabadi, Reza; Alton, Timothy] Univ Washington, Dept Orthopaed, Seattle, WA 98195 USA. [Wenke, Joseph] US Army Inst Surg Res, San Antonio, TX USA. RP Firoozabadi, R (reprint author), Univ Washington, Dept Orthopaed, Seattle, WA 98195 USA. NR 45 TC 2 Z9 2 U1 0 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1067-151X EI 1940-5480 J9 J AM ACAD ORTHOP SUR JI J. Am. Acad. Orthop. Surg. PD JUL PY 2015 VL 23 IS 7 BP 443 EP 451 DI 10.5435/JAAOS-D-14-00174 PG 9 WC Orthopedics; Surgery SC Orthopedics; Surgery GA CL3TK UT WOS:000356873300006 PM 26040954 ER PT J AU Gunia, BC Sipos, ML LoPresti, M Adler, AB AF Gunia, Brian C. Sipos, Maurice L. LoPresti, Matthew Adler, Amy B. TI Sleep Leadership in High-Risk Occupations: An Investigation of Soldiers on Peacekeeping and Combat Missions SO MILITARY PSYCHOLOGY LA English DT Article DE combat; leadership; peacekeeping; sleep; unit climate ID SUPPORTIVE SUPERVISOR BEHAVIORS; WORK-FAMILY CONFLICT; MENTAL-HEALTH; TRANSFORMATIONAL LEADERSHIP; NEUROCOGNITIVE CONSEQUENCES; GROUP CONSENSUS; SOCIAL SUPPORT; SAFETY; IRAQ; DEPRIVATION AB Individuals in high-risk occupations (e. g., military service) often report physical, psychological, and organizational problems. Although leaders can partially buffer their subordinates against these problems, the impact of established leadership skills appears limited, especially in high-risk occupations. Thus, building on recent theories of domain-specific leadership, we examined whether leadership focused on the specific domain of sleep might be negatively associated with some specific problems facing individuals in high-risk occupations, beyond their relationship with general leadership. Studying military personnel on peacekeeping and combat deployments, we predicted that "sleep leadership" would be negatively associated with sleep problems (physical), depressive symptoms (psychological), and negative climate (organizational), and that sleep would mediate the relationship between sleep leadership and the psychological and organizational problems. Results were generally supportive, contributing to theories of domain-specific leadership by showing that sleep-focused leader behaviors may go beyond general leadership behaviors, relating directly to the problems facing individuals in high-risk occupations. C1 [Gunia, Brian C.] Johns Hopkins Univ, Carey Business Sch, Baltimore, MD 21202 USA. [Gunia, Brian C.; Adler, Amy B.] Walter Reed Army Inst Res, US Army Med Res Unit Europe, Sembach, Germany. [Sipos, Maurice L.; LoPresti, Matthew] Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Silver Spring, MD USA. RP Gunia, BC (reprint author), Johns Hopkins Univ, Carey Business Sch, 100 Int Dr, Baltimore, MD 21202 USA. EM brian.gunia@jhu.edu RI Gunia, Brian/D-7887-2015 OI Gunia, Brian/0000-0001-8922-1747 NR 69 TC 1 Z9 1 U1 5 U2 18 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0899-5605 EI 1532-7876 J9 MIL PSYCHOL JI Milit. Psychol. PD JUL PY 2015 VL 27 IS 4 BP 197 EP 211 DI 10.1037/mil0000078 PG 15 WC Psychology, Multidisciplinary SC Psychology GA CL5BS UT WOS:000356975400001 ER PT J AU Kragh, JF Aden, JK Steinbaugh, J Bullard, M Dubick, MA AF Kragh, John F., Jr. Aden, James K. Steinbaugh, John Bullard, Mary Dubick, Michael A. TI Gauze vs XSTAT in wound packing for hemorrhage control SO AMERICAN JOURNAL OF EMERGENCY MEDICINE LA English DT Letter ID COMBAT CASUALTY CARE C1 [Kragh, John F., Jr.; Aden, James K.; Dubick, Michael A.] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Kragh, John F., Jr.] USAISR, Houston, TX USA. [Kragh, John F., Jr.] Uniformed Serv Univ Hlth Sci F Edward Hebert, Sch Med, Bethesda, MD USA. [Dubick, Michael A.] USAISR, Damage Control Resuscitat, Ft Sam Houston, TX USA. RP Kragh, JF (reprint author), US Army Inst Surg Res Damage Control Resuscitat, 3698 Chambers Pass,Ste B, Ft Sam Houston, TX 78234 USA. EM john.f.kragh.civ@mail.mil NR 2 TC 2 Z9 2 U1 4 U2 9 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0735-6757 EI 1532-8171 J9 AM J EMERG MED JI Am. J. Emerg. Med. PD JUL PY 2015 VL 33 IS 7 BP 974 EP 976 PG 4 WC Emergency Medicine SC Emergency Medicine GA CL0BG UT WOS:000356602900027 PM 25934248 ER PT J AU Edla, S Reisner, AT Liu, JB Convertino, VA Carter, R Reifman, J AF Edla, Shwetha Reisner, Andrew T. Liu, Jianbo Convertino, Victor A. Carter, Robert, III Reifman, Jaques TI In reply to "Utility of shock index calculation in hemorrhagic trauma" SO AMERICAN JOURNAL OF EMERGENCY MEDICINE LA English DT Letter ID VITAL SIGNS C1 [Edla, Shwetha; Liu, Jianbo; Reifman, Jaques] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Biotechnol High Performance Comp Software Applica, Dept Def, Ft Detrick, MD 21702 USA. [Reisner, Andrew T.] Massachusetts Gen Hosp, Dept Emergency Med, Boston, MA 02114 USA. [Convertino, Victor A.; Carter, Robert, III] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Reifman, J (reprint author), US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Biotechnol High Performance Comp Software Applica, Dept Def,ATTN MCMR TT, 504 Scott St, Ft Detrick, MD 21702 USA. EM jaques.reifman.civ@mail.mil NR 5 TC 1 Z9 1 U1 2 U2 2 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0735-6757 EI 1532-8171 J9 AM J EMERG MED JI Am. J. Emerg. Med. PD JUL PY 2015 VL 33 IS 7 BP 978 EP 979 DI 10.1016/j.ajem.2015.04.002 PG 4 WC Emergency Medicine SC Emergency Medicine GA CL0BG UT WOS:000356602900031 PM 25913084 ER PT J AU Jones, BH Hauschild, VD Dada, EO Grier, TL Cowan, DN AF Jones, Bruce H. Hauschild, Veronique D. Dada, Esther O. Grier, Tyson L. Cowan, David N. TI Regarding the Bulzacchelli et al. Article on Injury During US Army Basic Combat Training SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Letter ID RISK-FACTORS; TRAINEES; MEN C1 [Jones, Bruce H.; Hauschild, Veronique D.; Dada, Esther O.; Grier, Tyson L.] US Army Publ Hlth Command, Army Inst Publ Hlth, Aberdeen Proving Ground, MD 21010 USA. [Cowan, David N.] Walter Reed Army Inst Res, Prevent Med Branch, Silver Spring, MD USA. [Cowan, David N.] ManTech Int Corp, ManTech Hlth, Herndon, VA USA. RP Jones, BH (reprint author), US Army Publ Hlth Command, Army Inst Publ Hlth, Aberdeen Proving Ground, MD 21010 USA. NR 9 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 EI 1873-2607 J9 AM J PREV MED JI Am. J. Prev. Med. PD JUL PY 2015 VL 49 IS 1 BP E1 EP E3 DI 10.1016/j.amepre.2015.03.010 PG 3 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA CK6UI UT WOS:000356363400001 PM 26094236 ER PT J AU Gao, X Gillespie, JW Jensen, RE Li, W Haque, BZ McKnight, SH AF Gao, X. Gillespie, J. W., Jr. Jensen, R. E. Li, W. Haque, B. Z. (Gama) McKnight, S. H. TI Effect of fiber surface texture on the mechanical properties of glass fiber reinforced epoxy composite SO COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING LA English DT Article DE Glass fibers; Fiber/matrix interphase; Damage mechanisms; Punch shear & microdroplet testing ID THICK-SECTION COMPOSITES; FRACTURE-TOUGHNESS; ENERGY-ABSORPTION; BALLISTIC IMPACT; INTERPHASE PROPERTIES; PENETRATION MODEL; COLLOIDAL SILICA; INTERFACE; ADHESION; STRENGTH AB The effect of fiber sizing and surface texture on the strength and energy absorbing capacity of fiber reinforced composites has been evaluated at two length scales using the macromechanical quasi-static punch shear test and the micromechanical microdroplet test methods. E-Glass/SC-79 epoxy composite laminates with four different fiber sizing formulations with various degrees of chemical bonding and surface texture have been investigated. The failure modes during perforation and different energy dissipating damage mechanisms were identified and quantified. The punch shear strength and the total energy absorption per unit volume of composite with hybrid sizing have increased by 48% and 100% over the incompatible sizing. These results showed linear correlations with the interphase properties reported earlier by the authors (Gao et al., 2011) and provided a methodology for developing new sizing by tailoring chemical bonding and the fiber surface texture at the fiber matrix interphase for improving both strength and energy absorption of composites. (C) 2015 Elsevier Ltd: All rights reserved. C1 [Gao, X.; Gillespie, J. W., Jr.; Li, W.; Haque, B. Z. (Gama)] Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. [Gao, X.; Gillespie, J. W., Jr.] Dept Mat Sci & Engn, Newark, DE 19716 USA. [Gillespie, J. W., Jr.] Dept Civil & Environm Engn, Newark, DE 19716 USA. [Gillespie, J. W., Jr.; Haque, B. Z. (Gama)] Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA. [Jensen, R. E.; McKnight, S. H.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Haque, BZ (reprint author), Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA. EM gama@udel.edu FU Army Research Laboratory; [W911NF-06-2-0011]; [W911NF-12-2-0022] FX Research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-06-2-0011 and W911NF-12-2-0022. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. The authors wish to acknowledge Joseph Deitzel, Chaoying Ni, Maureen Foley and Andres Leal for their contribution and valuable discussions and the technical assistance provided by S.M. Waliul Islam, Mostafezur Rahman, John Thiravong and Anthony Thiravong at the University of Delaware. NR 24 TC 5 Z9 5 U1 5 U2 32 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1359-835X EI 1878-5840 J9 COMPOS PART A-APPL S JI Compos. Pt. A-Appl. Sci. Manuf. PD JUL PY 2015 VL 74 BP 10 EP 17 DI 10.1016/j.compositesa.2015.03.023 PG 8 WC Engineering, Manufacturing; Materials Science, Composites SC Engineering; Materials Science GA CK9IK UT WOS:000356553600002 ER PT J AU Fowler, KR Jenkins, EW Ostrove, C Chrispell, JC Farthing, MW Parno, M AF Fowler, K. R. Jenkins, E. W. Ostrove, C. Chrispell, J. C. Farthing, M. W. Parno, M. TI A decision making framework with MODFLOW-FMP2 via optimization: Determining trade-offs in crop selection SO ENVIRONMENTAL MODELLING & SOFTWARE LA English DT Article DE Simulation-based optimization; Multi-objective; Farm management ID EVOLUTIONARY ALGORITHMS; MANAGEMENT-PRACTICES; WATER AVAILABILITY; FARMING SYSTEMS; HIGH-PLAINS; DESIGN; SIMULATION; MODEL; SUSTAINABILITY; IRRIGATION AB Farmers in regions experiencing water stress or drought conditions can struggle to balance their crop portfolios. Periods of low precipitation often lead to increased, unsustainable reliance on groundwater-supplied irrigation. As a result, regional water management agencies place limits on the amount of water which can be obtained from groundwater, requiring farmers to reduce acreage for more water-intensive crops or remove them from the portfolio entirely. Real-time decisions must be made by the farmer to ensure viability of their farming operation and reduce the impacts associated with limited water resources. Evolutionary algorithms, coupled with accurate, flexible, realistic simulation tools, are ideal mechanisms to allow farmers to assess scenarios with regard to multiple, competing objectives. In order to effective, however, one must be able to select among a variety of simulation tools and optimization algorithms. Many simulation tools allow no access to the source code, and many optimization algorithms are now packaged as part of a suite of tools available to a user. In this work, we describe a framework for integrating these different software components using only their associated input and output streams. We analyze our strategy by coupling a multi-objective genetic algorithm available in the DAKOTA optimization suite (developed and distributed by Sandia National Laboratory) with the MODFLOW-FMP2 simulation tool (developed and distributed by the United States Geological Survey). MODFLOW-FMP2 has been used extensively to model hydrological and farming processes in agriculture-dciminated regions, allowing us to represent both farming and conservation interests. We evaluate our integration by considering a case study related to planting decisions facing farmers experiencing water stress. We present numerical results for three competing objectives associated with stakeholders in a given region (i.e., profitability, meeting demand targets, and water conservation). The data obtained from the optimization are robust with respect to algorithmic parameter choices, validating the ability of the associated evolutionary algorithm to perform well without expert guidance. This is integral to our approach, as a motivation for this work is providing decision-making tools. In addition, the results from this study demonstrate that output from the chosen evolutionary algorithm provides a suite of feasible planting scenarios, giving farmers and policy makers the ability to compromise solutions based on realistic simulation data. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Fowler, K. R.; Ostrove, C.] Clarkson Univ, Dept Math & Comp Sci, Potsdam, NY 13676 USA. [Jenkins, E. W.] Clemson Univ, Dept Math Sci, Clemson, SC USA. [Chrispell, J. C.] Indiana Univ Penn, Dept Math, Indiana, PA 15705 USA. [Farthing, M. W.] US Army Corps Engineers, Coastal & Hydraul Lab, Engineer Res & Dev Ctr, Vicksburg, MS USA. [Parno, M.] MIT, Dept Aeronaut & Astronaut, Cambridge, MA 02139 USA. RP Fowler, KR (reprint author), Clarkson Univ, Dept Math & Comp Sci, Potsdam, NY 13676 USA. EM krfowler@clarkson.edu; lea@clemson.edu; ostrovci@clarkson.edu; john.chrispell@iup.edu; matthew.w.farthing@erdc.dren.mil; mparno@mit.edu FU American Institute of Mathematics SQuaRE grant FX The authors wish to thank Dr. Randall Hanson of the United States Geological Survey for his assistance in coupling external software with the MODFLOW-FMP2 simulation tool, as well as the many useful discussions and insights on various aspects of the simulation tool. We also thank Dr. Stacy Howington of ERDC USACE for guidance on the hydrology. We also thank Stephen Carter of Mathworks for his initial algorithm development. This work was supported in part through an American Institute of Mathematics SQuaRE grant. NR 64 TC 3 Z9 3 U1 5 U2 26 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1364-8152 EI 1873-6726 J9 ENVIRON MODELL SOFTW JI Environ. Modell. Softw. PD JUL PY 2015 VL 69 BP 280 EP 291 DI 10.1016/j.envsoft.2014.11.031 PG 12 WC Computer Science, Interdisciplinary Applications; Engineering, Environmental; Environmental Sciences SC Computer Science; Engineering; Environmental Sciences & Ecology GA CK9GO UT WOS:000356548800024 ER PT J AU Lazarus, N Meyer, CD Bedair, SS AF Lazarus, Nathan Meyer, Chris D. Bedair, Sarah S. TI Stretchable Inductor Design SO IEEE TRANSACTIONS ON ELECTRON DEVICES LA English DT Article DE Compliant interconnect; inductor geometries; inductors; stretchable electronics ID ELECTRONIC-CIRCUITS; INTERCONNECTS; SYSTEMS AB High-quality inductors are difficult to realize in stretchable electronics, since the thick parallel traces needed to minimize resistance also result in a highly rigid structure. Adding periodic waves or kinks to the traces of an inductor coil has been found to result in a more compliant structure that will not permanently deform or break after stretching by tens of percent. In this paper, the effects on electrical performance of creating inductor coils from stretchable wavy traces are investigated. Eight different tortuous trace designs were modeled and experimentally tested in one-and three-turn inductors, as well as an electrical transformer design. Incorporating waves into an inductor was found to result in a negative mutual coupling along the traces, degrading the inductor performance. The incremental self-inductance per resistance of the added length due to the waviness, similar to 1.2 nH/Omega, was similar for all interconnect types tested. This value is less than a third that of using a longer straight conductor of similar cross section (4.4 nH/Omega), resulting in a drop in ratio of inductance to resistance and resulting peak quality factor in the measured inductors by as much as a factor of two. C1 [Lazarus, Nathan; Meyer, Chris D.; Bedair, Sarah S.] US Army Res Lab, Elect Devices Directorate, Adelphi, MD 20783 USA. RP Lazarus, N (reprint author), US Army Res Lab, Elect Devices Directorate, Adelphi, MD 20783 USA. EM nathan.lazarus2.civ@mail.mil; christopher.d.meyer1.civ@mail.mil; sarah.s.bedair.civ@mail.mil NR 20 TC 2 Z9 2 U1 1 U2 8 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9383 EI 1557-9646 J9 IEEE T ELECTRON DEV JI IEEE Trans. Electron Devices PD JUL PY 2015 VL 62 IS 7 BP 2270 EP 2277 DI 10.1109/TED.2015.2431221 PG 8 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA CK7ZY UT WOS:000356457900030 ER PT J AU Rutvisuttinunt, W Chinnawirotpisan, P Thaisomboonsuk, B Rodpradit, P Ajariyakhajorn, C Manasatienkij, W Simasathien, S Shrestha, SK Yoon, IK Klungthong, C Fernandez, S AF Rutvisuttinunt, W. Chinnawirotpisan, P. Thaisomboonsuk, B. Rodpradit, P. Ajariyakhajorn, C. Manasatienkij, W. Simasathien, S. Shrestha, S. K. Yoon, I. K. Klungthong, C. Fernandez, S. TI Viral subpopulation diversity in influenza virus isolates compared to clinical specimens SO JOURNAL OF CLINICAL VIROLOGY LA English DT Article DE Influenza; Viral subpopulations; Viral isolates; Clinical specimens; Variances; Next generation Sequencing ID BURROWS-WHEELER TRANSFORM; DNA-SEQUENCING DATA; A VIRUSES; NEURAMINIDASE INHIBITORS; ANTIVIRAL RESISTANCE; MOLECULAR MARKERS; A/H3N2 VIRUSES; READ ALIGNMENT; H1N1 VIRUSES; VACCINE AB Background: Influenza virus (IFV) isolates obtained from mammalian cell cultures are valuable reagents used for vaccine production, antigenic characterization, laboratory assays, and epidemiological and evolutionary studies. Complete genomic comparison of IFV isolates with their original clinical specimens provides insight into cell culture-driven genomic changes which may sequentially alter the virus phenotype. Objectives: The genome of the viral isolates and of the viruses in the clinical specimens was examined by deep sequencing in order to determine nucleotide heterogeneity (measured number of variances or numbers of mixed bases) as a marker for IFV population diversity. Study design: Clinical respiratory specimens were collected between July and October 2012 and identified by RT-PCR as positive for influenza A H3N2 or H1N1, or influenza B. The viruses in the clinical specimens were amplified using mammalian cell culture. Next generation sequencing (NGS) was used to investigate genomic differences between IFV isolates and their corresponding clinical specimens. Results: There was less nucleotide heterogeneity in 5 of 6 viral isolates compared to the corresponding clinical specimens, especially for influenza B. A phylogenetic analysis of the hemagglutinin (HA) gene consensus sequences obtained from deep and Sanger sequencing showed that the viral isolates and their corresponding clinical specimens contained the same IFV strains with less than 5% pair-wise genetic distance. Conclusion: The IFV sequence data analysis detected a substantial decrease in nucleotide heterogeneity from clinical specimens to viral cultures in 5 out of 6 investigated cases. (C) 2015 The Authors. Published by Elsevier B.V. C1 [Rutvisuttinunt, W.; Chinnawirotpisan, P.; Thaisomboonsuk, B.; Rodpradit, P.; Ajariyakhajorn, C.; Manasatienkij, W.; Yoon, I. K.; Klungthong, C.; Fernandez, S.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Simasathien, S.] Phramongkutklao Hosp, Bangkok, Thailand. [Shrestha, S. K.] Walter Reed AFRIMS Res Unit Nepal, Kathmandu, Nepal. RP Rutvisuttinunt, W (reprint author), Armed Forces Res Inst Med Sci, Dept Virol, 315-6 Rajavithi Rd, Bangkok 10400, Thailand. EM Wiriyar@afrims.org; PiyawanC@afrims.org; ButsayaT@afrims.org; PrinyadaR@afrims.org; ChuanpisA@afrims.org; WudtichaiM@afrims.org; ssriluck@hotmail.com; ShresthaSK@afrims.org; YoonI@afrims.org; ChontichaK@afrims.org; Fernandezs@afrims.org FU Armed Forces Health Surveillance Center - Global Emerging Infections Surveillance and Response System (AFHSC-GEIS) FX This work was supported by Armed Forces Health Surveillance Center - Global Emerging Infections Surveillance and Response System (AFHSC-GEIS). NR 38 TC 2 Z9 2 U1 0 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1386-6532 EI 1873-5967 J9 J CLIN VIROL JI J. Clin. Virol. PD JUL PY 2015 VL 68 BP 16 EP 23 DI 10.1016/j.jcv.2015.04.010 PG 8 WC Virology SC Virology GA CK3FF UT WOS:000356101300004 PM 26071329 ER PT J AU Skowronska, AG Gorsich, DJ Pandey, V Mourelatos, ZP AF Skowronska, Annette G. Gorsich, David J. Pandey, Vijitashwa Mourelatos, Zissimos P. TI Optimizing the Reliability and Performance of Remote Vehicle-to-Grid Systems Using a Minimal Set of Metrics SO JOURNAL OF ENERGY RESOURCES TECHNOLOGY-TRANSACTIONS OF THE ASME LA English DT Article ID ELECTRIC-DRIVE VEHICLES; FUEL-CELL VEHICLES; POWER; ENERGY AB Vehicles connected to electric systems are considered "plug-in" vehicles. They can be an integral part of a microgrid. Ground vehicles have become more electrified over time, providing electrical power for the propulsion system (hybrid) and a complex suite of auxiliary power systems, enhancing their use in microgrids. Optimizing the microgrid system for performance and reliability considering many external loads and sources is a challenging problem. This is especially true when the plug-in vehicles may enter and leave the microgrid randomly becoming either sources or loads. The microgrid is a repairable system. Recent work has shown that multiple metrics are needed to fully account for the performance of repairable systems under uncertainty. In this paper, we propose a decision-based framework to design and maintain repairable systems for optimal performance and reliability using a set of metrics such as minimum failure free period (MFFP), number of failures in planning horizon, and cost. Optimal tradeoffs among a minimal set of metrics (MSOM) can be used in the design and maintenance of these systems. The optimal solution includes the initial design, the system maintenance throughout the planning horizon, and the protocol to operate the system. Critical remote military installations with plug-in vehicles connected to the microgrids require careful consideration of cost and repair strategies because of logistical challenges in performing repairs and supplying necessary spare parts in unsafe locations. We show how a MSOM helps to solve the complex optimization problem of finding the best microgrid power management strategy considering performance, reliability, and cost. C1 [Skowronska, Annette G.; Gorsich, David J.] US Army TARDEC, Warren, MI 48397 USA. [Skowronska, Annette G.; Mourelatos, Zissimos P.] Oakland Univ, Dept Mech Engn, Rochester, MI 48309 USA. [Pandey, Vijitashwa] Oakland Univ, Ind & Syst Engn Dept, Rochester, MI 48309 USA. RP Mourelatos, ZP (reprint author), Oakland Univ, Dept Mech Engn, Rochester, MI 48309 USA. FU Automotive Research Center (ARC), a U.S. Army Center of Excellence in Modeling and Simulation of Ground Vehicles led by the University of Michigan FX This work was supported in part by the Automotive Research Center (ARC), a U.S. Army Center of Excellence in Modeling and Simulation of Ground Vehicles led by the University of Michigan. Such support does not constitute an endorsement by the sponsors of the opinions expressed in this article. NR 21 TC 0 Z9 0 U1 1 U2 3 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0195-0738 J9 J ENERG RESOUR-ASME JI J. Energy Resour. Technol.-Trans. ASME PD JUL PY 2015 VL 137 IS 4 AR 041204 DI 10.1115/1.4030317 PG 7 WC Energy & Fuels SC Energy & Fuels GA CL0GE UT WOS:000356618000004 ER PT J AU Medina, VF Johnson, JL Waisner, SA Wade, R Mattei-Sosa, J AF Medina, Victor F. Johnson, Jared L. Waisner, Scott A. Wade, Roy Mattei-Sosa, Jose TI Development of a Treatment Process for Electrodialysis Reversal Concentrate with Intermediate Softening and Secondary Reverse Osmosis to Approach 98-Percent Water Recovery SO JOURNAL OF ENVIRONMENTAL ENGINEERING LA English DT Article DE Electrodialysis; Intermediate softening; Reverse osmosis; High recovery ID DESALINATION; LIME AB The United States Army is constructing a new water-treatment facility for Fort Irwin/National Training Center in the Mojave Desert region of southern California to address existing regulatory requirements and to account for anticipated expansion at the installation. The proposed treatment, electrodialysis reversal (EDR), is anticipated to recover 92% of the influent water. The ultimate goal was to achieve 99% recovery, which required additional recovery of the EDR concentrate. This paper describes laboratory testing of conventional water-treatment methods to achieve water recovery beyond standard practice. The effectiveness of lime softening followed by secondary reverse osmosis (RO) was evaluated to treat the concentrate stream and recover additional water to approach 98%. Partial lime softening at dosages of 500 -2,000 mg/L of hydrated lime was capable of removing hardness from simulated EDR concentrate. Adding magnesium chloride to the lime softening step increased silica removal, bringing SiO2 concentrations in the simulated EDR concentrate from 110 to 6.8 mg/L at room temperature. The resulting treated water was suitable for effective reverse osmosis with a standard seawater polyamide membrane. Rejection for all of the dissolved constituents was well above 90% with the exception of arsenic, which was reduced from 50 mu g/L to levels on the order of 20 mu g/L. To achieve 99% recovery, mechanical vapor recompression is being considered to further recover the concentrate from the RO unit, although this unit process was not evaluated in the research reported in this paper. (C) 2015 American Society of Civil Engineers. C1 [Medina, Victor F.; Johnson, Jared L.; Waisner, Scott A.; Wade, Roy; Mattei-Sosa, Jose] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Medina, VF (reprint author), US Army Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM victor.f.medina@usace.army.mil OI Waisner, Scott/0000-0003-4360-4712 FU U.S. Army Military Construction (MILCON) program FX The writers would like acknowledge that funding for the research reported in this paper came from the U.S. Army Military Construction (MILCON) program. The water-treatment plant project was managed by Debra Ford and LTC Joseph Seybold of the Los Angeles District of the U.S. Army Corps of Engineers. Permission was granted by the Chief of Engineers to publish this information. The views expressed in this paper are those of the writers and do not reflect the official policy or position of the Department of the Army, Department of Defense, or the U.S. Government. The use of trade, product, or firm names in this paper is for descriptive purposes only and does not imply endorsement by the U.S. Government. NR 38 TC 0 Z9 0 U1 6 U2 19 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9372 EI 1943-7870 J9 J ENVIRON ENG JI J. Environ. Eng.-ASCE PD JUL PY 2015 VL 141 IS 7 AR 04015002 DI 10.1061/(ASCE)EE.1943-7870.0000929 PG 10 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA CK7EX UT WOS:000356395500003 ER PT J AU Semper, SR Crassidis, JL George, J Mukherjee, S Singla, P AF Semper, Sean R. Crassidis, John L. George, Jemin Mukherjee, Siddharth Singla, Puneet TI Rao-Blackwellization for Adaptive Gaussian Sum Nonlinear Model Propagation SO JOURNAL OF GUIDANCE CONTROL AND DYNAMICS LA English DT Article ID STATE-SPACE MODELS; PARTICLE FILTERS C1 [Semper, Sean R.] NASA, Goddard Space Flight Ctr, Guidance Nav & Control Hardware, Greenbelt, MD 20771 USA. [Semper, Sean R.] NASA, Components Branch, Greenbelt, MD 20771 USA. [George, Jemin] SUNY Buffalo, Dept Mech & Aerosp Engn, Space Situat Awareness, Amherst, NY 14260 USA. [George, Jemin] US Army Res Lab, Networked Sensing & Fus Branch, Adelphi, MD 20783 USA. [Mukherjee, Siddharth; Singla, Puneet] SUNY Buffalo, Dept Mech & Aerosp Engn, Amherst, NY 14260 USA. RP Semper, SR (reprint author), NASA, Goddard Space Flight Ctr, Guidance Nav & Control Hardware, Greenbelt, MD 20771 USA. EM sean.r.semper@nasa.gov; johnc@buffalo.edu; jemin.george.civ@mail.mil; smukherj@buffalo.edu; psingla@buffalo.edu RI Singla, Puneet/D-3642-2012 OI Singla, Puneet/0000-0002-2441-2531 NR 12 TC 1 Z9 1 U1 0 U2 0 PU AMER INST AERONAUTICS ASTRONAUTICS PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0731-5090 EI 1533-3884 J9 J GUID CONTROL DYNAM JI J. Guid. Control Dyn. PD JUL PY 2015 VL 38 IS 7 BP 1290 EP 1295 DI 10.2514/1.G001042 PG 6 WC Engineering, Aerospace; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA CK4HB UT WOS:000356183800011 ER PT J AU Howard, IL Carruth, WD AF Howard, Isaac L. Carruth, William D. TI Chemical Stabilization of VHMS for Disaster Recovery Applications SO JOURNAL OF MATERIALS IN CIVIL ENGINEERING LA English DT Article DE Portland cement; Soil stabilization; Clays; Disaster recovery; Shear strength; Moisture; Slurries; Soil modulus ID CEMENT; CLAY; BEHAVIOR AB Very high moisture content fine grained soils (abbreviated as VHMS for very high moisture soils) have been studied from many perspectives, yet their role in disaster recovery has not been heavily investigated. This paper's primary objective is to present material properties of portland cement stabilized VHMS and discuss its immediate reuse for disaster recovery. The paper focuses on laboratory properties that can be achieved by combinations of three soils with differing plasticity, seven portland cements at varying dosages, and two very high moisture levels. Approximately 1,200 unconfined compression tests were performed. Laboratory test results indicated shear strengths of 0.1-3.8kg/cm2 could be achieved after 1-7days of room temperature curing. Literature and practice review indicated chemically stabilized VHMS (i.e.,emergency construction material) could be mixed with pugmills or concrete ready-mix trucks, pumped 1-3.2km, and placed without mechanical compaction. Beneficial reuse after disaster recovery ceases is also likely in many applications. The overall assessment of the paper is that portland cement stabilized VHMS can be a viable solution for disaster recovery. C1 [Howard, Isaac L.] Mississippi State Univ, Dept Civil & Environm Engn, Mat & Construct Ind Chair, Mississippi State, MS 39762 USA. [Carruth, William D.] US Army Engineer Res & Dev Ctr, CEERD GM A, Vicksburg, MS 39180 USA. RP Carruth, WD (reprint author), US Army Engineer Res & Dev Ctr, CEERD GM A, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM ilhoward@cee.msstate.edu; William.D.Carruth@usace.army.mil FU Southeast Region Research Initiative (SERRI) at the Department of Energy's Oak Ridge National Laboratory FX The Department of Homeland Security sponsored by the Southeast Region Research Initiative (SERRI) at the Department of Energy's Oak Ridge National Laboratory funded this research, with Isaac L. Howard as the principal investigator. Tim Cost, PE, F.ACI and Holcim (US), Inc. are owed thanks for considerable in-kind support to this research. Permission to publish this paper was given by the Director, Geotechnical and Structures Laboratory, U.S. Army Engineer Research and Development Center. NR 21 TC 2 Z9 2 U1 0 U2 1 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0899-1561 EI 1943-5533 J9 J MATER CIVIL ENG JI J. Mater. Civ. Eng. PD JUL PY 2015 VL 27 IS 7 AR 04014200 DI 10.1061/(ASCE)MT.1943-5533.0001075 PG 8 WC Construction & Building Technology; Engineering, Civil; Materials Science, Multidisciplinary SC Construction & Building Technology; Engineering; Materials Science GA CK7OF UT WOS:000356421200007 ER PT J AU Cacioppo, JT Adler, AB Lester, PB McGurk, D Thomas, JL Chen, HY Cacioppo, S AF Cacioppo, John T. Adler, Amy B. Lester, Paul B. McGurk, Dennis Thomas, Jeffrey L. Chen, Hsi-Yuan Cacioppo, Stephanie TI Building Social Resilience in Soldiers: A Double Dissociative Randomized Controlled Study SO JOURNAL OF PERSONALITY AND SOCIAL PSYCHOLOGY LA English DT Article DE social isolation; military; loneliness; training; group randomized trial ID MENTAL-HEALTH; IRAQ RANDOMIZATION; POSITIVE EVENTS; CHICAGO HEALTH; SELF-EFFICACY; PRIMARY-CARE; LONELINESS; INTERVENTIONS; SCALE; TRUST AB Can social resilience be trained? We report results of a double-dissociative randomized controlled study in which 48 Army platoons were randomly assigned to social resilience training (intervention condition) or cultural awareness training (active control group). The same surveys were administered to all platoons at baseline and after the completion of training to determine the short-term training effects, generalization effects beyond training, and possible adverse effects. Multilevel modeling analyses indicated that social resilience, compared with cultural awareness, training produced small but significant improvements in social cognition (e.g., increased empathy, perspective taking, & military hardiness) and decreased loneliness, but no evidence was found for social resilience training to generalize beyond these training foci nor to have adverse effects. Moreover, as predicted, cultural awareness, compared with social resilience, training produced increases in knowledge about and decreases in prejudice toward Afghans. Additional research is warranted to determine the long-term durability, safety, and generalizability of social resilience training. C1 [Cacioppo, John T.] Univ Chicago, Dept Psychol, Dept Psychiat & Behav Neurosci, Chicago, IL 60637 USA. [Cacioppo, John T.; Chen, Hsi-Yuan; Cacioppo, Stephanie] Univ Chicago, Ctr Cognit & Social Neurosci, Chicago, IL 60637 USA. [Adler, Amy B.; Thomas, Jeffrey L.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Lester, Paul B.] Army Analyt Grp, Res Facilitat Lab, Monterey, CA USA. [McGurk, Dennis] US Army Med Res & Mat Command, Frederick, MD USA. [Cacioppo, Stephanie] Univ Chicago, Dept Psychiat & Behav Neurosci, Chicago, IL 60637 USA. RP Cacioppo, JT (reprint author), Univ Chicago, Dept Psychol, 5848 S Univ Ave, Chicago, IL 60637 USA. EM Cacioppo@uchicago.edu FU Department of the Army [W81XWH-11-2-0114] FX This research was supported by Department of the Army Award W81XWH-11-2-0114 and was reviewed and approved by the University of Chicago Institutional Review Board (IRB H11297) and the U.S. Army Medical Research and Material Command Human Research Protection Office (HRPO A-16547). We express our gratitude to Rhonda Cornum, Kenneth Riddle, Louise Hawkley, Maike Luhmann, Jessica Bell, Harry Reis, Alex Zautra, Katharine Nassauer, Ramon Prieto, D. Alan Nelson, Mike Fravell, Katie Nasser, Carson Mayo, Josh Mayo, Paul Bliese, and the Social Awareness and Action Training team for their contributions to various aspects of this research. NR 95 TC 5 Z9 5 U1 5 U2 22 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0022-3514 EI 1939-1315 J9 J PERS SOC PSYCHOL JI J. Pers. Soc. Psychol. PD JUL PY 2015 VL 109 IS 1 BP 90 EP 105 DI 10.1037/pspi0000022 PG 16 WC Psychology, Social SC Psychology GA CK9ZR UT WOS:000356598600006 PM 26098588 ER PT J AU Mulligan, RP Walsh, JP Wadman, HM AF Mulligan, Ryan P. Walsh, J. P. Wadman, Heidi M. TI Storm Surge and Surface Waves in a Shallow Lagoonal Estuary during the Crossing of a Hurricane SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING LA English DT Article DE Surface waves; Cyclones; Storm surge; Hurricanes; Estuaries; Hydrodynamics; Floods; Barrier islands; Lagoons; Surface waves; Storm surge; Hurricanes; Currents; Estuaries; Wave modeling; Hydrodynamic modeling; Flooding; High water levels; Barrier islands ID PAMLICO SOUND; MODEL; VALIDATION; SYSTEM; TRANSPORT; IRENE; WATER; WIND; NC AB Tropical cyclones deliver intense winds that can generate some of the most severe surface wave and storm surge conditions in the coastal ocean. Hurricane Irene (2011) crossed a large, shallow lagoonal estuarine system in North Carolina, causing flooding and erosion of the adjacent low-lying coastal plain and barrier islands. This event provided an opportunity to improve understanding of the estuarine response to strong and rotating wind forcing. Observations from acoustic sensors in subestuaries and water-level elevation measurements from a network of pressure sensors across the system are presented. Data are examined with two modeling techniques: (1) a simple numerical approach using a momentum balance between the wind stress, flow acceleration, pressure gradient, and bottom friction that gives insight into temporal variability in water levels through the passage of the storm; and (2) an advanced hydrodynamic model based on the full shallow water fluid momentum equations, coupled to a spectral surface wave model that accounts for the spatially varying bathymetry and wind field. The results indicate that both wind-generated surface waves and the wind-driven storm surge are important contributors to the total water surface elevations that induce flooding along estuarine shorelines under strong hurricane forcing. C1 [Mulligan, Ryan P.] Queens Univ, Dept Civil Engn, Kingston, ON K7L 3N6, Canada. [Walsh, J. P.] E Carolina Univ, Dept Geol Sci, Greenville, NC 27858 USA. [Wadman, Heidi M.] US Army COE, Field Res Facil, Duck, NC 27949 USA. RP Mulligan, RP (reprint author), Queens Univ, Dept Civil Engn, Kingston, ON K7L 3N6, Canada. EM mulliganr@civil.queensu.ca FU U.S. National Science Foundation; David Mallinson at East Carolina University (ECU); Natural Science and Engineering Research Council of Canada; Research Initiation Grant from Queen's University FX This work is motivated by the need to understand the response of the APES to hurricanes and to climate change, funded by the U.S. National Science Foundation, with David Mallinson at East Carolina University (ECU). R. P. Mulligan also acknowledges support from the Natural Science and Engineering Research Council of Canada and a Research Initiation Grant from Queen's University. The authors thank Jesse McNinch, Jeff Hanson, and Kent Hathaway at the FRF for the Aquadopp data and D. Reide Corbett at ECU for deploying the Vector just before the hurricane. Helpful comments from Bill Birkemeier and three anonymous reviewers are gratefully acknowledged. NR 32 TC 0 Z9 0 U1 5 U2 16 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-950X EI 1943-5460 J9 J WATERW PORT COAST JI J. Waterw. Port Coast. Ocean Eng. PD JUL PY 2015 VL 141 IS 4 AR A5014001 DI 10.1061/(ASCE)WW.1943-5460.0000260 PG 11 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA CK5CW UT WOS:000356240800007 ER PT J AU Radoshitzky, SR Bao, YM Buchmeier, MJ Charrel, RN Clawson, AN Clegg, CS DeRisi, JL Emonet, S Gonzalez, JP Kuhn, JH Lukashevich, IS Peters, CJ Romanowski, V Salvato, MS Stenglein, MD de la Torre, JC AF Radoshitzky, Sheli R. Bao, Yimng Buchmeier, Michael J. Charrel, Remi N. Clawson, Anna N. Clegg, Christopher S. DeRisi, Joseph L. Emonet, Sebastien Gonzalez, Jean-Paul Kuhn, Jens H. Lukashevich, Igor S. Peters, Clarence J. Romanowski, Victor Salvato, Maria S. Stenglein, Mark D. de la Torre, Juan Carlos TI Past, present, and future of arenavirus taxonomy SO ARCHIVES OF VIROLOGY LA English DT Article DE Arenavirid; Arenaviridae; Arenavirus; Bat virus; Bibdavirus; ICTV; Inclusion body disease; International Committee on Taxonomy of Viruses; Mammarenavirus; PASC; Reptarenavirus; Rodent virus; Snake virus; TaxoProp; Viral hemorrhagic fever; Virus classification; Virus nomenclature; Virus taxonomy ID LYMPHOCYTIC CHORIOMENINGITIS VIRUS; FINGER-Z-PROTEIN; OLD-WORLD ARENAVIRUSES; INCLUSION-BODY DISEASE; VIRAL-RNA SYNTHESIS; LASSA-VIRUS; PICHINDE VIRUS; WEST-AFRICA; PHYLOGENETIC ANALYSIS; FAMILY-ARENAVIRIDAE AB Until recently, members of the monogeneric family Arenaviridae (arenaviruses) have been known to infect only muroid rodents and, in one case, possibly phyllostomid bats. The paradigm of arenaviruses exclusively infecting small mammals shifted dramatically when several groups independently published the detection and isolation of a divergent group of arenaviruses in captive alethinophidian snakes. Preliminary phylogenetic analyses suggest that these reptilian arenaviruses constitute a sister clade to mammalian arenaviruses. Here, the members of the International Committee on Taxonomy of Viruses (ICTV) Arenaviridae Study Group, together with other experts, outline the taxonomic reorganization of the family Arenaviridae to accommodate reptilian arenaviruses and other recently discovered mammalian arenaviruses and to improve compliance with the Rules of the International Code of Virus Classification and Nomenclature (ICVCN). PAirwise Sequence Comparison (PASC) of arenavirus genomes and NP amino acid pairwise distances support the modification of the present classification. As a result, the current genus Arenavirus is replaced by two genera, Mammarenavirus and Reptarenavirus, which are established to accommodate mammalian and reptilian arenaviruses, respectively, in the same family. The current species landscape among mammalian arenaviruses is upheld, with two new species added for Lunk and Merino Walk viruses and minor corrections to the spelling of some names. The published snake arenaviruses are distributed among three new separate reptarenavirus species. Finally, a non-Latinized binomial species name scheme is adopted for all arenavirus species. In addition, the current virus abbreviations have been evaluated, and some changes are introduced to unequivocally identify each virus in electronic databases, manuscripts, and oral proceedings. C1 [Radoshitzky, Sheli R.] US Army Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Bao, Yimng] NIH, Informat Engn Branch, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20892 USA. [Buchmeier, Michael J.] Univ Calif Irvine, Dept Mol Biol & Biochem, Irvine, CA 92717 USA. [Charrel, Remi N.] Aix Marseille Univ, Emergence Pathol Virales EPV UMR D 190, IRD, French Inst Res Dev,EHESP,French Sch Publ Hlth, F-13385 Marseille, France. [Clawson, Anna N.; Kuhn, Jens H.] NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD USA. [DeRisi, Joseph L.] Univ Calif San Francisco, Dept Med, San Francisco, CA USA. [DeRisi, Joseph L.] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA. [DeRisi, Joseph L.] Univ Calif San Francisco, Dept Microbiol, San Francisco, CA 94143 USA. [Emonet, Sebastien] Echelon Rech Lyon, IRBA, Unite Virol, Lyon, France. [Gonzalez, Jean-Paul] Metabiota Inc, Emerging Dis & Biosecur, Washington, DC USA. [Lukashevich, Igor S.] Univ Louisville, Sch Med, Dept Pharmacol & Toxicol, Ctr Predict Med Biodef & Emerging Infect Dis, Louisville, KY 40292 USA. [Peters, Clarence J.] Univ Texas Med Branch, Galveston Natl Lab, Galveston, TX 77555 USA. [Romanowski, Victor] CONICET UNLP, CCT La Plata, Inst Biotecnol & Biol Mol, La Plata, Buenos Aires, Argentina. [Salvato, Maria S.] Univ Maryland, Sch Med, Inst Human Virol, Baltimore, MD 21201 USA. [Stenglein, Mark D.] Colorado State Univ, Dept Microbiol Immunol & Pathol, Ft Collins, CO 80523 USA. [de la Torre, Juan Carlos] Scripps Res Inst, Dept Immunol & Microbial Sci IMM 6, La Jolla, CA 92037 USA. [Charrel, Remi N.] Hosp Marseille, IHU Mediterranee Infect, APHM Publ Hosp Marseille, F-13385 Marseille, France. RP Radoshitzky, SR (reprint author), US Army Med Res Inst Infect Dis, 1425 Porter St, Frederick, MD 21702 USA. EM sheli.r.radoshitzky.ctr@mail.mil; juanct@scripps.edu RI Stenglein, Mark/E-3541-2017 OI Stenglein, Mark/0000-0002-0993-813X FU National Institutes of Health/National Institute of Allergy and Infectious Diseases [HHSN272200700016I]; National Institutes of Health, National Library of Medicine FX The content of this publication does not necessarily reflect the views or policies of the US Department of Health and Human Services, the US Department of the Army, the US Department of Defense or of the institutions and companies affiliated with the authors. JHK performed this work as an employee of Tunnell Government Services, Inc., and ANC as the owner of Logos Consulting, Inc., both subcontractors to Battelle Memorial Institute under its prime contract with the National Institutes of Health/National Institute of Allergy and Infectious Diseases, under Contract No. HHSN272200700016I. YB's contribution was also supported in part by the Intramural Research Program of the National Institutes of Health, National Library of Medicine. NR 144 TC 20 Z9 20 U1 1 U2 19 PU SPRINGER WIEN PI WIEN PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA SN 0304-8608 EI 1432-8798 J9 ARCH VIROL JI Arch. Virol. PD JUL PY 2015 VL 160 IS 7 BP 1851 EP 1874 DI 10.1007/s00705-015-2418-y PG 24 WC Virology SC Virology GA CK3FA UT WOS:000356100800030 PM 25935216 ER PT J AU Clayton, JD Tonge, AL AF Clayton, J. D. Tonge, A. L. TI A nonlinear anisotropic elastic-inelastic constitutive model for polycrystalline ceramics and minerals with application to boron carbide SO INTERNATIONAL JOURNAL OF SOLIDS AND STRUCTURES LA English DT Article DE Nonlinear elasticity; Plasticity; Shock physics; Ceramics; Minerals ID GRAIN-BOUNDARY PROPERTIES; SHOCK-WAVE COMPRESSION; BRITTLE MATERIALS; MICROMECHANICAL MODEL; BALLISTIC PERFORMANCE; DYNAMIC COMPRESSION; TITANIUM DIBORIDE; POROUS MATERIALS; SINGLE-CRYSTALS; FINITE STRAIN AB A new continuum constitutive theory is developed and implemented for study of polycrystalline brittle solids subjected to possibly large stress and finite deformation. The general theory accounts for elastic anisotropy, nonlinear elasticity (via higher-order elastic constants), thermoelastic coupling, and various inelastic deformation mechanisms, including, but not restricted to, fracture, pore crushing, bulking, and stress-induced amorphization. The internal energy function depends on a logarithmic measure of material strain, entropy, and internal state variables accounting for defect accumulation, for example effects of micro-cracks on the tangent stiffness of the solid. The theory is applied towards a study of dynamic compression of boron carbide ceramic. Solutions to a planar impact problem are Investigated for isotropic and anisotropic, i.e., textured, polycrystals. For the isotropic case, an implementation of the theory containing only two fitting parameters whereby conjugate thermodynamic forces provide evolution laws for damage and granular flow provides close agreement with Hugoniot data. Poled boron carbide polycrystals shocked along the c-axis are predicted to demonstrate higher peak shear stress, but reduced ductility, relative to isotropic polycrystals. Amorphization associated with nonlinear elastic instability is predicted to occur at smaller volumetric compression in poled boron carbide than its isotropic counterpart, which could further reduce relative ductility and strength of the former. Published by Elsevier Ltd. C1 [Clayton, J. D.; Tonge, A. L.] US Army Res Lab, Impact Phys RDRL WMP C, Aberdeen Proving Ground, MD 21005 USA. [Clayton, J. D.] Univ Maryland, A James Clark Sch Engn, College Pk, MD 20742 USA. [Tonge, A. L.] Oak Ridge Associated Univ, Oak Ridge, TN 37831 USA. RP Clayton, JD (reprint author), US Army Res Lab, Impact Phys RDRL WMP C, Aberdeen Proving Ground, MD 21005 USA. EM john.d.clayton1.civ@mail.mil; andrew.l.tonge.civ@mail.mil RI Clayton, John/C-7760-2009 NR 106 TC 6 Z9 6 U1 3 U2 26 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0020-7683 EI 1879-2146 J9 INT J SOLIDS STRUCT JI Int. J. Solids Struct. PD JUL PY 2015 VL 64-65 BP 191 EP 207 DI 10.1016/j.ijsolstr.2015.03.024 PG 17 WC Mechanics SC Mechanics GA CK3JQ UT WOS:000356112800017 ER PT J AU Zheng, ZL Joshi, U Henein, N Sattler, E AF Zheng, Ziliang Joshi, Umashankar Henein, Naeim Sattler, Eric TI Effect of Cetane Improver on Combustion and Emission Characteristics of Coal-Derived Sasol Isomerized Paraffinic Kerosene in a Single Cylinder Diesel Engine SO JOURNAL OF ENGINEERING FOR GAS TURBINES AND POWER-TRANSACTIONS OF THE ASME LA English DT Article ID NUMBER; FUEL; PERFORMANCE; BLEND AB Sasol isomerized paraffinic kerosene (IPK) is a coal-derived synthetic fuel under consideration as a blending stock with JP-8 for use in military ground vehicles. Since Sasol IPK is a low ignition quality fuel with derived cetane number (DCN) of 31, there is a need to improve its ignition quality. This paper investigates the effect of adding different amounts of Lubrizol 8090 cetane improver to Sasol IPK on increasing its DCN. The experimental investigation was conducted in a single cylinder research type diesel engine. The engine is equipped with a common rail injection system and an open engine control unit. Experiments covered different injection pressures and intake air temperatures. Analysis of test results was made to determine the effect of cetane improver percentage in the coal-derived Sasol IPK blend on auto-ignition, combustion and emissions of carbon monoxide (CO), total unburned hydrocarbon (HC), oxides of nitrogen (NOx), and particulate matter (PM). In addition, the effect of cetane improver on the apparent activation energy of the global auto-ignition reactions was determined. C1 [Zheng, Ziliang; Joshi, Umashankar; Henein, Naeim] Wayne State Univ, Detroit, MI 48202 USA. [Sattler, Eric] US Army RDECOM TARDEC, Warren, MI 48092 USA. RP Zheng, ZL (reprint author), Wayne State Univ, 5050 Anthony Wayne Dr Suite 2100, Detroit, MI 48202 USA. EM zhengziliang@gmail.com; umashankar.joshi84@gmail.com; henein@eng.wayne.edu FU U.S. Army RDECOM-TARDEC; U.S. Department of Energy; Next Energy and Automotive Research Center (ARC): A Center of Excellence in Simulation and Modeling - U.S. Army RDECOM-TARDEC FX This research was sponsored by U.S. Army RDECOM-TARDEC, U.S. Department of Energy, Next Energy and Automotive Research Center (ARC): A Center of Excellence in Simulation and Modeling sponsored by U.S. Army RDECOM-TARDEC and directed by University of Michigan. Our special thanks are to Patsy Muzzell and Dr. Peter Schihl of U.S. Army RDECOM-TARDEC. We also would like to thank National Bio-fuel Energy Laboratory, Lidia Nedeltcheva, Eugene Snowden, and Wayne State University Center of Automotive Research (CAR) members for their help in conducting this research. NR 46 TC 5 Z9 5 U1 4 U2 9 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0742-4795 EI 1528-8919 J9 J ENG GAS TURB POWER JI J. Eng. Gas. Turbines Power-Trans. ASME PD JUL PY 2015 VL 137 IS 7 AR 071506 DI 10.1115/1.4029207 PG 11 WC Engineering, Mechanical SC Engineering GA CJ8RD UT WOS:000355770300009 ER PT J AU Downer, CW Pradhan, NR Ogden, FL Byrd, AR AF Downer, Charles W. Pradhan, Nawa Raj Ogden, Fred L. Byrd, Aaron R. TI Testing the Effects of Detachment Limits and Transport Capacity Formulation on Sediment Runoff Predictions Using the US Army Corps of Engineers GSSHA Model SO JOURNAL OF HYDROLOGIC ENGINEERING LA English DT Article DE Hydrology; Sediment; Sediment transport; Detachment limits; Transport capacity; Modeling ID SOIL-EROSION PROCESSES; SPLASH DETACHMENT; INTERRILL; INFILTRATION; FLOW AB The physics-based Gridded Surface Subsurface Hydrologic Analysis (GSSHA) model was developed by the U.S. Army Corps of Engineers for hydrologic, sediment transport, and water quality analyses. GSSHA simulates erosion and transport of sediments on the overland flow plain based on rainfall intensity and overland flow depth and velocity. The original sediment transport capabilities in GSSHA were taken from the GSSHA predecessor, CASC2D-SED. Independent testing of the sediment transport methods in CASC2D-SED by researchers identified several deficiencies in the formulation that caused significant overestimation of sediment yield during hydrologic events that were much larger than a calibration event. Sediment detachment limits and a variety of overland sediment transport equations were incorporated into the GSSHA model to address these deficiencies. This paper presents an evaluation of these modifications in terms of GSSHA sediment yield predictions of both single-event and summer growing season sediment yields. Simulation results are compared with research-quality sediment discharge data set from the USDA Goodwin Creek Experimental Watershed (GCEW). Results show that the reformulated GSSHA sediment transport model predicts event-total sediment discharge volume within (+/-) 50% over hydrologic events that vary by three orders of magnitude. The transport capacity method selected for use in the simulation had a large effect on the model results. C1 [Downer, Charles W.; Pradhan, Nawa Raj; Byrd, Aaron R.] Engineer Res & Dev Ctr, Hydrol Syst Branch, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. [Ogden, Fred L.] Univ Wyoming, Dept Civil & Architectural Engn, Engn Environm & Nat Resources, Laramie, WY 82071 USA. RP Downer, CW (reprint author), Engineer Res & Dev Ctr, Hydrol Syst Branch, Coastal & Hydraul Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM charles.w.downer@usace.army.mil FU U.S. Army Research Office [52454EVDPS] FX The authors acknowledge the USDA-ARS National Sedimentation Laboratory in Oxford, Mississippi, for providing access to the Goodwin Creek Experimental Watershed data set. This work was partially supported by the U.S. Army Research Office through Grant 52454EVDPS to the third author. NR 36 TC 0 Z9 0 U1 9 U2 13 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1084-0699 EI 1943-5584 J9 J HYDROL ENG JI J. Hydrol. Eng. PD JUL PY 2015 VL 20 IS 7 AR 04014082 DI 10.1061/(ASCE)HE.1943-5584.0001104 PG 11 WC Engineering, Civil; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA CK5CB UT WOS:000356238600014 ER PT J AU Hossain, F Arnold, J Beighley, E Brown, C Burian, S Chen, J Madadgar, S Mitra, A Niyogi, D Pielke, R Tidwell, V Wegner, D AF Hossain, Faisal Arnold, Jeffrey Beighley, Ed Brown, Casey Burian, Steve Chen, Ji Madadgar, Shahrbanou Mitra, Anindita Niyogi, Dev Pielke, Roger, Sr. Tidwell, Vincent Wegner, Dave TI Local-To-Regional Landscape Drivers of Extreme Weather and Climate: Implications for Water Infrastructure Resilience SO JOURNAL OF HYDROLOGIC ENGINEERING LA English DT Article ID PROBABLE MAXIMUM PRECIPITATION; USE/LAND COVER CHANGES; AMERICAN RIVER; LAND-USE; IMPACTS; RAINFALL; MODELS; FUTURE; DAM; MANAGEMENT AB Forum papers are thought-provoking opinion pieces or essays founded in fact, sometimes containing speculation, on a civil engineering topic of general interest and relevance to the readership of the journal. The views expressed in this Forum article do not necessarily reflect the views of ASCE or the Editorial Board of the journal. C1 [Hossain, Faisal] Univ Washington, Dept Civil & Environm Engn, Seattle, WA 98195 USA. [Arnold, Jeffrey] US Army Corps Engineers, Inst Water Resources, Seattle, WA USA. [Beighley, Ed] Northeastern Univ, Dept Civil & Environm Engn, Boston, MA 02115 USA. [Brown, Casey] Univ Massachusetts, Dept Civil & Environm Engn, Amherst, MA 01003 USA. [Burian, Steve] Univ Utah, Dept Civil & Environm Engn, Salt Lake City, UT 84112 USA. [Chen, Ji] Univ Hong Kong, Dept Civil Engn, Pokfulam, Hong Kong, Peoples R China. [Madadgar, Shahrbanou] Univ Calif Irvine, Civil & Environm Engn, Irvine, CA 92697 USA. [Mitra, Anindita] PERSI, Planning Sustainable Infrastruct, AICP, Seattle, WA 98103 USA. [Niyogi, Dev] Purdue Univ, Dept Agron Crops Soils & Environm Sci, W Lafayette, IN 47907 USA. [Niyogi, Dev] Purdue Univ, Dept Earth Atmospher & Planetary Sci, W Lafayette, IN 47907 USA. [Pielke, Roger, Sr.] Univ Colorado, CIRES, Boulder, CO 80309 USA. [Tidwell, Vincent] Sandia Natl Labs, Albuquerque, NM 87185 USA. [Wegner, Dave] Comm Transportat & Infrastruct, Subcomm Water Resources & Environm, Washington, DC 20515 USA. RP Hossain, F (reprint author), Univ Washington, Dept Civil & Environm Engn, More Hall 201, Seattle, WA 98195 USA. EM fhossain@uw.edu RI Chen, Ji/C-1795-2009; OI Burian, Steven/0000-0003-0523-4968 NR 62 TC 1 Z9 1 U1 5 U2 17 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1084-0699 EI 1943-5584 J9 J HYDROL ENG JI J. Hydrol. Eng. PD JUL PY 2015 VL 20 IS 7 AR 02515002 DI 10.1061/(ASCE)HE.1943-5584.0001210 PG 9 WC Engineering, Civil; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA CK5CB UT WOS:000356238600023 ER PT J AU Ulrich, MP AF Ulrich, Marybeth Peterson TI Civil-Military Relations and Shared Responsibility: A Four-Nation Study SO RUSSIAN REVIEW LA English DT Book Review C1 [Ulrich, Marybeth Peterson] US Army War Coll, Carlisle, PA USA. RP Ulrich, MP (reprint author), US Army War Coll, Carlisle, PA USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0036-0341 EI 1467-9434 J9 RUSS REV JI Russ. Rev. PD JUL PY 2015 VL 74 IS 3 BP 526 EP 527 PG 2 WC History SC History GA CK3AM UT WOS:000356087400042 ER PT J AU Delano, MJ Rizoli, SB Rhind, SG Cuschieri, J Junger, W Baker, AJ Dubick, MA Hoyt, DB Bulger, EM AF Delano, Matthew J. Rizoli, Sandro B. Rhind, Shawn G. Cuschieri, Joseph Junger, Wolfgang Baker, Andrew J. Dubick, Michael A. Hoyt, David B. Bulger, Eileen M. TI Prehospital Resuscitation of Traumatic Hemorrhagic Shock with Hypertonic Solutions Worsens Hypocoagulation and Hyperfibrinolysis SO SHOCK LA English DT Article ID SALINE RESUSCITATION; INDUCED COAGULOPATHY; HYPOVOLEMIC SHOCK; BLUNT TRAUMA; COAGULATION; ACTIVATION; FLUID; DEXTRAN; TRIAL; HYPOPERFUSION AB Impaired hemostasis frequently occurs after traumatic shock and resuscitation. The prehospital fluid administered can exacerbate subsequent bleeding and coagulopathy. Hypertonic solutions are recommended as first-line treatment of traumatic shock; however, their effects on coagulation are unclear. This study explores the impact of resuscitation with various hypertonic solutions on early coagulopathy after trauma. We conducted a prospective observational subgroup analysis of large clinical trial on out-of-hospital single-bolus (250 mL) hypertonic fluid resuscitation of hemorrhagic shock trauma patients (systolic blood pressure, <= 70 mmHg). Patients received 7.5% NaCl (HS), 7.5% NaCl/6% Dextran 70 (HSD), or 0.9% NaCl (normal saline [NS]) in the prehospital setting. Thirty-four patients were included: 9 HS, 8 HSD, 17 NS. Treatment with HS/HSD led to higher admission systolic blood pressure, sodium, chloride, and osmolarity, whereas lactate, base deficit, fluid requirement, and hemoglobin levels were similar in all groups. The HSD-resuscitated patients had higher admission international normalized ratio values and more hypocoagulable patients, 62% (vs. 55% HS, 47% NS; P < 0.05). Prothrombotic tissue factor was elevated in shock treated with NS but depressed in both HS and HSD groups. Fibrinolytic tissue plasminogen activator and anti-fibrinolytic plasminogen activator inhibitor type 1 were increased by shock but not thrombin-activatable fibrinolysis inhibitor. The HSD patients had the worst imbalance between procoagulation/anticoagulation and profibrinolysis/antifibrinolysis, resulting in more hypocoagulability and hyperfibrinolysis. We concluded that resuscitation with hypertonic solutions, particularly HSD, worsens hypocoagulability and hyperfibrinolysis after hemorrhagic shock in trauma through imbalances in both procoagulants and anticoagulants and both profibrinolytic and antifibrinolytic activities. C1 [Delano, Matthew J.] Univ Michigan, Dept Surg, Div Acute Care Surg, Ann Arbor, MI 48109 USA. [Hoyt, David B.] Univ Calif Irvine, Dept Surg, Amer Coll Surg, Irvine, CA 92717 USA. [Rizoli, Sandro B.] St Michaels Hosp, Dept Surg & Crit Care Med, Toronto, ON M5B 1W8, Canada. [Rhind, Shawn G.] Univ Toronto, Def Res & Dev Canada Toronto, Toronto, ON, Canada. [Cuschieri, Joseph; Bulger, Eileen M.] Univ Washington, Harborview Med Ctr, Dept Surg, Seattle, WA 98104 USA. [Junger, Wolfgang] Harvard Univ, Beth Israel Deaconess Med Ctr, Dept Surg, Sch Med, Boston, MA 02215 USA. [Baker, Andrew J.] Univ Toronto, St Michaels Hosp, Li Ka Shing Knowledge Inst, Brain Injury Lab,Cara Phelan Ctr Trauma Res Keena, Toronto, ON, Canada. [Dubick, Michael A.] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX USA. RP Delano, MJ (reprint author), Univ Michigan, Dept Surg, Div Acute Care Surg, Surg,Univ Hosp, 1C340D 1500 E Med Ctr Dr,SPC 5033, Ann Arbor, MI 48109 USA. EM mjdelano@umich.edu OI Delano, Matthew/0000-0001-7540-5166 FU National Institutes of Health NIGMS [1R01GM76101-01]; Defence Research and Development Canada FX This work was funded in part by grants from the National Institutes of Health NIGMS 1R01GM76101-01 and Defence Research and Development Canada. NR 45 TC 11 Z9 11 U1 1 U2 12 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUL PY 2015 VL 44 IS 1 BP 25 EP 31 DI 10.1097/SHK.0000000000000368 PG 7 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA CK5DQ UT WOS:000356242800004 PM 25784523 ER PT J AU Alayev, Y Bar-Noy, A Johnson, MP Kaplan, L La Porta, TF AF Alayev, Yosef Bar-Noy, Amotz Johnson, Matthew P. Kaplan, Lance La Porta, Thomas F. TI You can't get there from here: sensor scheduling with refocusing delays SO WIRELESS NETWORKS LA English DT Article DE Sensor scheduling; Delay constraints; Sensor networks; Sensors; Surveillance; Resource allocation; Algorithms ID NETWORKS; SERVICE AB We study a problem in which a single sensor is scheduled to observe sites periodically, motivated by applications in which the goal is to maintain up-to-date readings for all the observed sites. In the existing literature, it is typically assumed that the time for a sensor switching from one site to another is negligible. This may not be the case in applications such as camera surveillance of a border, however, in which the camera takes time to pan and tilt to refocus itself to a new geographical location. We formulate a problem with constraints modeling refocusing delays. We prove the problem to be NP-hard and then study a special case in which refocusing is proportional to some Euclidian metric. We give a lower bound on the optimal cost for the scheduling problem, and we derive exact solutions for some special cases of the problem. Finally, we provide and experimentally evaluate several heuristic algorithms, some of which are based on the computed lower bound, for the setting of one sensor and many sites. C1 [Alayev, Yosef] CUNY, Grad Ctr, Comp Sci, New York, NY 10017 USA. [Bar-Noy, Amotz] CUNY Brooklyn Coll, Comp & Informat Sci, New York, NY USA. [Bar-Noy, Amotz] CUNY, Grad Ctr, Dept Comp Sci, New York, NY USA. [Johnson, Matthew P.] CUNY, Grad Ctr, New York, NY USA. [Johnson, Matthew P.] CUNY Herbert H Lehman Coll, Comp Sci, New York, NY USA. [Kaplan, Lance] US Army Res Lab, Sensors & Electron Device Directorate, Adelphi, MD USA. [La Porta, Thomas F.] Penn State Univ, Comp Sci & Engn, State Coll, PA USA. RP Alayev, Y (reprint author), CUNY, Grad Ctr, Comp Sci, New York, NY 10017 USA. EM yosef.alayev@gmail.com; amotz@sci.brooklyn.cuny.edu; mpjohnson@gmail.com; lkaplan@arl.army.mil; tlp@cse.psu.edu FU US Army Research laboratory; UK Ministry of Defence FX This research was sponsored by US Army Research laboratory and the UK Ministry of Defence and was accomplished under Agreement Number W911NF-06-3-0001. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the US Army Research Laboratory, the US Government, the UK Ministry of Defence, or the UK Government. The US and UK Governments are authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation hereon. NR 21 TC 0 Z9 0 U1 0 U2 2 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1022-0038 EI 1572-8196 J9 WIREL NETW JI Wirel. Netw. PD JUL PY 2015 VL 21 IS 5 BP 1683 EP 1698 DI 10.1007/s11276-014-0873-0 PG 16 WC Computer Science, Information Systems; Engineering, Electrical & Electronic; Telecommunications SC Computer Science; Engineering; Telecommunications GA CK3DN UT WOS:000356096800019 ER PT J AU Engel, CC Litz, B Magruder, KM Harper, E Gore, K Stein, N Yeager, D Liu, X Coe, TR AF Engel, Charles C. Litz, Brett Magruder, Kathryn M. Harper, Elizabeth Gore, Kristie Stein, Nathan Yeager, Derik Liu, Xian Coe, T. Ray TI Delivery of self training and education for stressful situations (DESTRESS-PC): a randomized trial of nurse assisted online self-management for PTSD in primary care SO GENERAL HOSPITAL PSYCHIATRY LA English DT Article DE Posttraumatic Stress Disorder; Depression; Military mental health; Primary care; Telehealth ID COMORBIDITY SURVEY REPLICATION; MENTAL-HEALTH PROBLEMS; POSTTRAUMATIC-STRESS; DISORDER; DEPRESSION; PREVALENCE; SEVERITY; INTERNET; IRAQ; AFGHANISTAN AB Objective: This randomized controlled trial examined the effectiveness of a nurse assisted online cognitive-behavioral self-management intervention forwar-related posttraumatic stress disorder (PTSD), compared to optimized usual primary care PTSD Treatment (OUC) to reduce PTSD symptoms. Method: Participants were 80 veterans of recent military conflicts with PTSD as assessed by the PTSD Checklist (PCL) seeking primary care treatment at one of three Veterans Affairs (VA) and four Army clinics. DESTRESS-PC consisted of logins to a secure website three times per week for 6 weeks with monitoring by a study nurse. All participants received nurse care management in the form of phone check-ins every two weeks and feedback to their primary care providers. Blinded raters assessed outcomes 6, 12, and 18 weeks post-randomization. Results: DESTRESS-PC was associated with a significantly greater decrease in PTSD symptoms compared to OUC (F(3, 186)=3.72, p=.012). The effect was largest at the 12-week assessment (Delta PCL=12.6 +/- 16.6 versus 5.7 +/- 12.5, p<0.05) with the treatment effect disappearing by the 18-week follow-up. Notably, there was a dose effect; number of logins correlated significantly with PTSD outcomes, with more logins associated with greater PTSD symptom improvement. None of the secondary outcomes (depression, anxiety, somatic symptoms, and functional status) showed statistically significant improvement; however, the treatment effect on depression approached significance (F(3, 186)=2.17, p=.093). Conclusions: DESTRESS-PC shows promise as a means of delivering effective, early PTSD treatment in primary care. Larger trials are needed. (C) 2015 Elsevier Inc. All rights reserved. C1 [Engel, Charles C.; Liu, Xian] Uniformed Serv Univ Hlth Sci, Dept Psychiat, Bethesda, MD 20814 USA. [Litz, Brett; Stein, Nathan] VA Boston Healthcare Syst, Massachusetts Vet Epidemiol Res & Informat Ctr, Jamaica Plain, MA USA. [Litz, Brett; Stein, Nathan] Boston Univ, Dept Psychiat, Boston, MA 02215 USA. [Magruder, Kathryn M.; Yeager, Derik] Ralph H Johnson VA Med Ctr, Charleston, SC USA. [Magruder, Kathryn M.; Yeager, Derik] Med Univ S Carolina, Dept Psychiat, Charleston, SC 29425 USA. [Harper, Elizabeth; Gore, Kristie; Liu, Xian] Walter Reed Natl Mil Med Ctr, Deployment Hlth Clin Ctr, Bethesda, MD USA. [Liu, Xian] Uniformed Serv Univ Hlth Sci, Dept Psychiat, Ctr Study Traumat Stress, Bethesda, MD 20814 USA. [Coe, T. Ray] Womack Army Med Ctr, Ft Bragg, NC USA. RP Engel, CC (reprint author), RAND Corp, 1200 South Hayes St, Arlington, VA 22202 USA. EM cengel@rand.org FU NIMH NIH HHS [R34 MH078874] NR 32 TC 3 Z9 3 U1 4 U2 15 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0163-8343 EI 1873-7714 J9 GEN HOSP PSYCHIAT JI Gen. Hosp. Psych. PD JUL-AUG PY 2015 VL 37 IS 4 BP 323 EP 328 DI 10.1016/j.genhosppsych.2015.04.007 PG 6 WC Psychiatry SC Psychiatry GA CJ5UG UT WOS:000355555800010 PM 25929985 ER PT J AU Alfson, KJ Avena, LE Beadles, MW Staples, H Nunneley, JW Ticer, A Dick, EJ Owston, MA Reed, C Patterson, JL Carrion, R Griffiths, A AF Alfson, Kendra J. Avena, Laura E. Beadles, Michael W. Staples, Hilary Nunneley, Jerritt W. Ticer, Anysha Dick, Edward J., Jr. Owston, Michael A. Reed, Christopher Patterson, Jean L. Carrion, Ricardo, Jr. Griffiths, Anthony TI Particle-to-PFU Ratio of Ebola Virus Influences Disease Course and Survival in Cynomolgus Macaques SO JOURNAL OF VIROLOGY LA English DT Article ID DEFECTIVE INTERFERING PARTICLES; HEMORRHAGIC-FEVER; RNA VIRUS; INFECTION; FILOVIRUSES; EVOLUTION; CULTURES; ANIMALS; GENOMES; RULE AB This study addresses the role of Ebola virus (EBOV) specific infectivity in virulence. Filoviruses are highly lethal, enveloped, single-stranded negative-sense RNA viruses that can cause hemorrhagic fever. No approved vaccines or therapies exist for filovirus infections, and infectious virus must be handled in maximum containment. Efficacy testing of countermeasures, in addition to investigations of pathogenicity and immune response, often requires a well-characterized animal model. For EBOV, an obstacle in performing accurate disease modeling is a poor understanding of what constitutes an infectious dose in animal models. One well-recognized consequence of viral passage in cell culture is a change in specific infectivity, often measured as a particle-toPFU ratio. Here, we report that serial passages of EBOV in cell culture resulted in a decrease in particle-to-PFU ratio. Notably, this correlated with decreased potency in a lethal cynomolgus macaque (Macaca fascicularis) model of infection; animals were infected with the same viral dose as determined by plaque assay, but animals that received more virus particles exhibited increased disease. This suggests that some particles are unable to form a plaque in a cell culture assay but are able to result in lethal disease in vivo. These results have a significant impact on how future studies are designed to model EBOV disease and test countermeasures. IMPORTANCE Ebola virus (EBOV) can cause severe hemorrhagic disease with a high case-fatality rate, and there are no approved vaccines or therapies. Specific infectivity can be considered the total number of viral particles per PFU, and its impact on disease is poorly understood. In stocks of most mammalian viruses, there are particles that are unable to complete an infectious cycle or unable to cause cell pathology in cultured cells. We asked if these particles cause disease in nonhuman primates by infecting monkeys with equal infectious doses of genetically identical stocks possessing either high or low specific infectivities. Interestingly, some particles that did not yield plaques in cell culture assays were able to result in lethal disease in vivo. Furthermore, the number of PFU needed to induce lethal disease in animals was very low. Our results have a significant impact on how future studies are designed to model EBOV disease and test countermeasures. C1 [Alfson, Kendra J.; Avena, Laura E.; Beadles, Michael W.; Staples, Hilary; Nunneley, Jerritt W.; Ticer, Anysha; Patterson, Jean L.; Carrion, Ricardo, Jr.; Griffiths, Anthony] Texas Biomed Res Inst, Dept Virol & Immunol, San Antonio, TX 78227 USA. [Alfson, Kendra J.; Griffiths, Anthony] Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol & Immunol, San Antonio, TX 78229 USA. [Dick, Edward J., Jr.; Owston, Michael A.] Texas Biomed Res Inst, Southwest Natl Primate Res Ctr, San Antonio, TX USA. [Reed, Christopher] US Army Med Res Inst Infect Dis, Div Virol, Frederick, MD USA. RP Griffiths, A (reprint author), Texas Biomed Res Inst, Dept Virol & Immunol, San Antonio, TX 78227 USA. EM agriffiths@txbiomed.org FU Department of Defense Medical Countermeasure Systems-Joint Vaccine Acquisition Program [W911QY-12-C-0076]; Research Facilities Improvement Program from the NCRR [C06 RR012087]; U.S. Department of Defense (DoD) Joint Project Manager Medical Countermeasure Systems (JPM-MCS) [W911QY-12-C-0076] FX This work was supported by the Department of Defense Medical Countermeasure Systems-Joint Vaccine Acquisition Program (W911QY-12-C-0076). This work was conducted in facilities constructed with support from the Research Facilities Improvement Program (grant number C06 RR012087) from the NCRR.; This work is currently being conducted under contract W911QY-12-C-0076 with the U.S. Department of Defense (DoD) Joint Project Manager Medical Countermeasure Systems (JPM-MCS). The views expressed here are those of the authors and do not necessarily represent the views or official position of the DoD or JPM-MCS. NR 34 TC 8 Z9 8 U1 0 U2 9 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X EI 1098-5514 J9 J VIROL JI J. Virol. PD JUL PY 2015 VL 89 IS 13 BP 6773 EP 6781 DI 10.1128/JVI.00649-15 PG 9 WC Virology SC Virology GA CJ6GW UT WOS:000355593000021 PM 25903348 ER PT J AU Mikita-Barbato, RA Kelly, JJ Tate, RL AF Mikita-Barbato, Robyn A. Kelly, John J. Tate, Robert L., III TI Wildfire effects on the properties and microbial community structure of organic horizon soils in the New Jersey Pinelands SO SOIL BIOLOGY & BIOCHEMISTRY LA English DT Article DE Wildfire; Bacteria; Archaea; Fungi; Organic horizon ID GRADIENT GEL-ELECTROPHORESIS; 16S RIBOSOMAL-RNA; PRESCRIBED FIRE; BACTERIAL COMMUNITIES; FOREST SOIL; NONTUBERCULOUS MYCOBACTERIA; UNITED-STATES; PINE-BARRENS; DIVERSITY; LITTER AB The frequency and intensity of wildfires are expected to increase in the coming years due to the changing climate, particularly in areas of high net primary production. Wildfires represent severe perturbations to terrestrial ecosystems and may have lasting effects. The objective of this study was to characterize the impacts of wildfire on an ecologically and economically important ecosystem by linking soil properties to shifts in microbial community structure in organic horizon soils. The study was conducted after a severe wildfire burned over 7000 ha of the New Jersey Pinelands, a low nutrient system with a historical incidence of fires. Soil properties in burned and non-burned soils were measured periodically up to two years after the fire occurred, in conjunction with molecular analysis of the soil bacterial, fungal and archaeal communities to determine the extent and duration of the ecosystem responses. The results of our study indicate that the wildfire resulted in significant changes in the soil physical and chemical characteristics in the organic horizon, including declines in soil organic matter, moisture content and total Kjeldahl nitrogen. These changes persisted for up to 25 months post-fire and were linked to shifts in the composition of soil bacterial, fungal and archaeal communities in the organic horizon. Of particular interest is the fact that the bacterial, fungal and archaeal communities in the severely burned soils all changed most dramatically during the first year after fire, changed more slowly during the second year after the fire, and were still distinct from communities in the non-burned soils 25 months post-fire. This slow recovery in soil physical, chemical and biological properties could have long term consequences for the soil ecosystem. These results highlight the importance of relating the response of the soil microbial communities to changing soil properties after a naturally occurring wildfire. Published by Elsevier Ltd. C1 [Mikita-Barbato, Robyn A.; Tate, Robert L., III] Rutgers State Univ, Dept Environm Sci, New Brunswick, NJ 08901 USA. [Kelly, John J.] Loyola Univ, Dept Biol, Chicago, IL 60660 USA. RP Mikita-Barbato, RA (reprint author), Cold Reg Res & Engn Lab, Engn Res & Dev Ctr, 72 Lyme Rd, Hanover, NH 03257 USA. EM robyn.a.barbato@erdc.dren.mil NR 76 TC 4 Z9 4 U1 3 U2 51 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0038-0717 J9 SOIL BIOL BIOCHEM JI Soil Biol. Biochem. PD JUL PY 2015 VL 86 BP 67 EP 76 DI 10.1016/j.soilbio.2015.03.021 PG 10 WC Soil Science SC Agriculture GA CJ4ZF UT WOS:000355496500009 ER PT J AU Watson, R Gray, W Sponsel, WE Lund, BJ Glickman, RD Groth, SL Reilly, MA AF Watson, Richard Gray, Walt Sponsel, William E. Lund, Brian J. Glickman, Randolph D. Groth, Sylvia L. Reilly, Matthew A. TI Simulations of Porcine Eye Exposure to Primary Blast Insult SO TRANSLATIONAL VISION SCIENCE & TECHNOLOGY LA English DT Article DE primary blast; ocular trauma; computational modeling; injury modeling; simulation ID OPTIC-NERVE INJURY; FINITE-ELEMENT; TRAUMA; IMPACT; MODEL; LENS; MECHANISMS; IRAQI; WAR AB Purpose: A computational model of the porcine eye was developed to simulate primary blast exposure. This model facilitates understanding of blast-induced injury mechanisms. Methods: A computational model of the porcine eye was used to simulate the effects of primary blast loading for comparison with experimental findings from shock tube experiments. The eye model was exposed to overpressure-time histories measured during physical experiments. Deformations and mechanical stresses within various ocular tissues were then examined for correlation with pathological findings in the experiments. Results: Stresses and strains experienced in the eye during a primary blast event increase as the severity of the blast exposure increases. Peak stresses in the model occurred in locations in which damage was most often observed in the physical experiments. Conclusions: Blast injuries to the anterior chamber may be due to inertial displacement of the lens and ciliary body while posterior damage may arise due to contrecoup interactions of the vitreous and retina. Correlation of modeling predictions with physical experiments lends confidence that the model accurately represents the conditions found in the physical experiments. Translational Relevance: This computational model offers insights into the mechanisms of ocular injuries arising due to primary blast and may be used to simulate the effects of new protective eyewear designs. C1 [Watson, Richard; Sponsel, William E.; Reilly, Matthew A.] Univ Texas San Antonio, Dept Biomed Engn, San Antonio, TX USA. [Watson, Richard] Biodynamic Res Corp, San Antonio, TX USA. [Gray, Walt] Univ Texas San Antonio, Dept Geol Sci, San Antonio, TX USA. [Sponsel, William E.] WESMD Profess Associates, San Antonio, TX USA. [Sponsel, William E.] Univ Incarnate Word, Rosenberg Sch Optometry, San Antonio, TX USA. [Lund, Brian J.] US Army, Inst Surg Res, JBSA Ft Sam Houston, San Antonio, TX USA. [Glickman, Randolph D.] Univ Texas Hlth Sci Ctr San Antonio, Dept Ophthalmol, San Antonio, TX 78229 USA. [Groth, Sylvia L.] Univ N Carolina, Dept Ophthalmol, Sch Med, Chapel Hill, NC USA. RP Reilly, MA (reprint author), 1 UTSA Circle, San Antonio, TX 78249 USA. EM Matthew.reilly@utsa.edu FU U.S. Army Medical Research and Material Command under Vision Research Program [W81XWH-12-2-0055] FX Supported by the U.S. Army Medical Research and Material Command under Vision Research Program Grant Number W81XWH-12-2-0055. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official views of the Department of the Army of the Department of Defense. NR 35 TC 1 Z9 1 U1 1 U2 1 PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC PI ROCKVILLE PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA SN 2164-2591 J9 TRANSL VIS SCI TECHN JI Transl. Vis. Sci. Technol. PD JUL PY 2015 VL 4 IS 4 AR 8 DI 10.1167/tvst.4.4.8 PG 11 WC Ophthalmology SC Ophthalmology GA ED2FS UT WOS:000388659900008 ER PT J AU Wu, X Grover, N Paskaleva, EE Mundra, RV Page, MA Kane, RS Dordick, JS AF Wu, Xia Grover, Navdeep Paskaleva, Elena E. Mundra, Ruchir V. Page, Martin A. Kane, Ravi S. Dordick, Jonathan S. TI Characterization of the activity of the spore cortex lytic enzyme CwlJ1 SO BIOTECHNOLOGY AND BIOENGINEERING LA English DT Article DE CwlJ1; amidase; germination; cortex; Bacillus anthracis ID BACILLUS-SUBTILIS; CRYSTAL-STRUCTURE; PEPTIDOGLYCAN-BINDING; CATALYTIC DOMAIN; IN-VITRO; GERMINATION; ANTHRACIS; BACTERIOPHAGE; RESISTANCE; ENDOLYSIN AB The germination enzyme CwlJ1 plays an important role in degrading the cortex during the germination of Bacillus anthracis spores. However, the specific function and catalytic activity of CwlJ1 remain elusive. Here we report for the first time a detailed in vitro mechanistic study of CwlJ1 expressed in Escherichia coli and its activity against the spore cortical fragments of B. anthracis when added exogenously. CwlJ1 was active on both decoated spores and spore cortical fragments. Through liquid chromatography-mass spectrometry analysis of the digested cortical fragments, we determined that CwlJ1 was a thermostable N-acetylmuramoyl-l-alanine amidase. CwlJ1 mainly recognized large segments of glycan chains in the cortex instead of the minimal structural unit tetrasaccharide, with specificity for muramic acid--lactam-containing glycan chains and preference for the tetrapeptide side chain. Unlike most amidases, CwlJ1 did not appear to contain a divalent cation, as it retained its activity in the presence of EDTA. This study shines some light on the mechanism of spore germination, and provides increased insight into the development of sporicidal enzyme systems for decontamination of B. anthracis and other related bacteria. Biotechnol. Bioeng. 2015;112: 1365-1375. (c) 2015 Wiley Periodicals, Inc. C1 [Wu, Xia; Mundra, Ruchir V.; Kane, Ravi S.; Dordick, Jonathan S.] Rensselaer Polytech Inst, Howard P Isermann Dept Chem & Biol Engn, Troy, NY 12180 USA. [Wu, Xia; Grover, Navdeep; Paskaleva, Elena E.; Mundra, Ruchir V.; Kane, Ravi S.; Dordick, Jonathan S.] Rensselaer Polytech Inst, Ctr Biotechnol & Interdisciplinary Studies, Troy, NY 12180 USA. [Page, Martin A.] US Army Engn Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL USA. [Dordick, Jonathan S.] Rensselaer Polytech Inst, Dept Biomed Engn, Dept Biol, Dept Mat Sci & Engn, Troy, NY 12180 USA. RP Dordick, JS (reprint author), Rensselaer Polytech Inst, Howard P Isermann Dept Chem & Biol Engn, 110 8th St, Troy, NY 12180 USA. EM kaner@rpi.edu; dordick@rpi.edu OI Wu, Xia/0000-0002-4161-6552 FU Defense Threat Reduction Agency FX Contract grant sponsor: Defense Threat Reduction Agency NR 40 TC 0 Z9 0 U1 0 U2 8 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0006-3592 EI 1097-0290 J9 BIOTECHNOL BIOENG JI Biotechnol. Bioeng. PD JUL PY 2015 VL 112 IS 7 BP 1365 EP 1375 DI 10.1002/bit.25565 PG 11 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA CJ2RW UT WOS:000355333200009 PM 25676066 ER PT J AU Nezafati, M Sohn, I Ferguson, JB Park, JS Cho, K Kim, CS AF Nezafati, Marjan Sohn, Il Ferguson, J. B. Park, Joon-Sang Cho, Kyu Kim, Chang-Soo TI DFT study on the adsorption and absorption behaviors of liquid nitrogen in the Mg nano alloys synthesized from powder metallurgy SO COMPUTATIONAL MATERIALS SCIENCE LA English DT Article DE Density-functional theory; Cryomilling; Liquid nitrogen; Powder metallurgy; Magnesium nano alloys ID MECHANICAL-PROPERTIES; NANOCOMPOSITES; MAGNESIUM; STRENGTH; MICROSTRUCTURE; NANOPARTICLES; COMPOSITE; MOLECULES; DUCTILITY; ENERGY AB Mg-based metal-matrix nanocomposites (MMNCs) are lauded as one of the most promising structural materials for vehicle, military, and construction applications. These Mg MMNCs are often synthesized using the powder metallurgy (PM) process under liquid nitrogen cryogenic environments to control the grain sizes. It is believed that proper incorporation of the nitrogen species into the bulk lattice during processing could strongly enhance the mechanical properties of MMNCs by forming N-rich dispersoids. In this work, using the density-functional theory (DFT), we have studied the adsorption and absorption phenomena of liquid nitrogen molecule/atoms that can be applied to the Mg MMNC PM processing. The study includes the impacts of binding sites, alloying elements (Al, Zn, and Y), and surface crystallographic planes on the nitrogen molecule adsorption energies. We also examined the transition state (TS) behaviors for the bond breaking and lattice diffusion of nitrogen. The results show that similar to 1.13 eV would be required for nitrogen molecule to break the triple bonding and to diffuse into the Mg bulk lattice. Also, it was found that addition of Y can greatly enhance the binding strength of N-2 molecule on the Mg surface. (C) 2015 Elsevier B.V. All rights reserved. C1 [Nezafati, Marjan; Ferguson, J. B.; Kim, Chang-Soo] Univ Wisconsin, Mat Sci & Engn Dept, Milwaukee, WI 53211 USA. [Sohn, Il] Yonsei Univ, Mat Sci & Engn Dept, Seoul 120749, South Korea. [Park, Joon-Sang] Hongik Univ, Dept Comp Engn, Seoul 121791, South Korea. [Cho, Kyu] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Kim, CS (reprint author), Univ Wisconsin, Mat Sci & Engn Dept, 3200 N Cramer St, Milwaukee, WI 53211 USA. EM kimcs@uwm.edu OI Nezafati, Marjan/0000-0002-6939-0460 FU U.S. Army Research Laboratory [W911NF-08-2-0014] FX This material is based upon work supported by the U.S. Army Research Laboratory under Cooperative Agreement No. W911NF-08-2-0014. The views, opinions, and conclusions made in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 30 TC 3 Z9 3 U1 4 U2 22 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0927-0256 EI 1879-0801 J9 COMP MATER SCI JI Comput. Mater. Sci. PD JUL PY 2015 VL 105 BP 18 EP 26 DI 10.1016/j.commatsci.2015.04.017 PG 9 WC Materials Science, Multidisciplinary SC Materials Science GA CJ0CK UT WOS:000355139800004 ER PT J AU Munday, LB Crone, JC Knap, J AF Munday, Lynn B. Crone, Joshua C. Knap, Jaroslaw TI The role of free surfaces on the formation of prismatic dislocation loops SO SCRIPTA MATERIALIA LA English DT Article DE Dislocation dynamics; Void growth; Image stress; Cross-slip ID VOID GROWTH; DYNAMICS; SIMULATIONS; INCLUSION; MODEL AB Prismatic punching is a process where voids grow through the nucleation and emission of prismatic dislocation loops (PDLs). In this work we employ dislocation dynamics to determine the effect of image stresses produced by the void's free surface on PDL formation in a face-centered cubic lattice. We find that image stresses cause PDL formation to fall into two distinct pressure regimes. In the low pressure regime, image stresses dominate dislocation cross-slip, reducing the PDL's size and formation rate. Published by Elsevier Ltd. on behalf of Acta Materialia Inc. C1 [Munday, Lynn B.; Crone, Joshua C.; Knap, Jaroslaw] US Army, Res Lab, RDRL CIH C, Aberdeen Proving Ground, MD 21005 USA. RP Munday, LB (reprint author), US Army, Res Lab, RDRL CIH C, Aberdeen Proving Ground, MD 21005 USA. EM lynn.b.munday.civ@mail.mil FU U.S. Army Research Laboratory's Enterprise for Multiscale Research of Materials FX Support of the U.S. Army Research Laboratory's Enterprise for Multiscale Research of Materials is gratefully acknowledged. Computing support was provided by the MD Supercomputing Resource Center located at the U.S. Army Research Laboratory. NR 19 TC 4 Z9 4 U1 4 U2 15 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6462 J9 SCRIPTA MATER JI Scr. Mater. PD JUL 1 PY 2015 VL 103 BP 65 EP 68 DI 10.1016/j.scriptamat.2015.03.009 PG 4 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA CH9GE UT WOS:000354343200017 ER PT J AU Garcia-Avila, M Portanova, M Rabiei, A AF Garcia-Avila, Matias Portanova, Marc Rabiei, Afsaneh TI Ballistic performance of composite metal foams SO COMPOSITE STRUCTURES LA English DT Article DE Composite metal foam; Dynamic loading; Hollow spheres; Powder metallurgy; Ballistics; Finite element analysis ID ARMOR CERAMICS INFLUENCE; ALUMINUM-STEEL; DESIGN AB The application of advance materials to manufacture hard armor systems has led to high performance ballistic protection. Due to its light-weight and high impact energy absorption capabilities, composite metal foams have shown good potential for applications as ballistic armor. A high-performance lightweight composite armor system has been manufactured using boron carbide ceramics as the strike face, composite metal foam processed by powder metallurgy technique as a bullet kinetic energy absorber interlayer, and aluminum 7075 or Kevlar (TM) panels as backplates with a total armor thickness less than 25 mm. The ballistic tolerance of this novel composite armor system has been evaluated against the 7.62 x 51 mm M80 and 7.62 x 63 mm M2 armor piercing projectiles according to U.S. National Institute of Justice (NIJ) standard 0101.06. The results showed that composite metal foams absorbed approximately 60-70% of the total kinetic energy of the projectile effectively and stopped both types of projectiles with less depth of penetration and backplate deformation than that specified in the NIJ 0101.06 standard guidelines. Finite element analysis was performed using Abaqus/Explicit to study the failure mechanisms and energy absorption of the armor system. The results showed close agreement between experimental and analytical results. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Garcia-Avila, Matias; Rabiei, Afsaneh] N Carolina State Univ, Dept Mech & Aerosp Engn, Adv Mat Res Lab, Raleigh, NC 27695 USA. [Portanova, Marc] US Army Res Dev & Engn Ctr, Aviat Appl Technol Directorate, Ft Eustis, VA USA. RP Rabiei, A (reprint author), N Carolina State Univ, Dept Mech & Aerosp Engn, 911 Oval Dr,Campus Box 7910, Raleigh, NC 27695 USA. EM arabiei@ncsu.edu FU North Carolina State University FX The authors would like to acknowledge North Carolina State University's Chancellor Innovation Fund (CIF) for its financial support that made this project possible. Special thanks to Dr. Robert Bryant and his team at the Advanced Materials and Processing Branch at NASA Langley Research Center, for granting access to their material processing facilities. NR 33 TC 5 Z9 6 U1 8 U2 67 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0263-8223 EI 1879-1085 J9 COMPOS STRUCT JI Compos. Struct. PD JUL PY 2015 VL 125 BP 202 EP 211 DI 10.1016/j.compstruct.2015.01.031 PG 10 WC Materials Science, Composites SC Materials Science GA CG3JX UT WOS:000353177600022 ER PT J AU Li, XY Deng, ZD Martinez, JJ Fu, T Titzler, PS Hughes, JS Weiland, MA Brown, RS Trumbo, BA Ahmann, ML Renholds, JF AF Li, Xinya Deng, Zhiqun D. Martinez, Jayson J. Fu, Tao Titzler, P. Scott Hughes, James S. Weiland, Mark A. Brown, Richard S. Trumbo, Bradly A. Ahmann, Martin L. Renholds, Jon F. TI Three-dimensional tracking of juvenile salmon at a mid-reach location between two dams SO FISHERIES RESEARCH LA English DT Article DE Acoustic telemetry; 3-D tracking; Juvenile salmon; Mid-reach reservoir ID ACOUSTIC TELEMETRY SYSTEM; POSITION ACCURACY; LOCALIZATION; PASSAGE; FISH; INSTRUMENTATION; DESIGN; RIVERS; TAGS AB Evaluating fish behavior and migration in response to environmental changes is a fundamental component of fisheries research and recovery of freshwater ecosystems. While spatial distribution and behavior of fishes has been well studied around hydropower facilities, little research has been conducted at a mid-reach location between two dams. The Juvenile Salmon Acoustic Telemetry System (JSATS) cabled receiver system was developed and employed as a reference sensor network for detecting and tracking juvenile salmon in the Columbia River Basin. To supplement acquisition of detection and three-dimensional (3-D) tracking data to estimate survival and fish behavior in the forebays of Little Goose and Lower Monumental dams on the Snake River in eastern Washington State, a mid-reach location was needed to investigate the spatial distribution of migrating juvenile salmon in open-water conditions between the two dams. Lyons Ferry Bridge on State Route 261 at the confluence of the Snake and Palouse Rivers was chosen as the mid-reach location. A JSATS-cabled receiver system configuration was successfully designed and deployed from the bridge's pier structure. Theoretical analysis confirmed the functionality and precision of the deployment design. Validation tests demonstrated sub-meter accuracy of 3-D tracking up to a horizontal distance of 50 m upstream and downstream from the Lyons Ferry Bridge piers. Detection and tracking probabilities of the LFB cabled array were estimated to be 99.98% from field application. This research provided a detailed description of acoustic telemetry system deployment and 3-D tracking as guidance for better understanding of fish migration behavior as they pass through dams and continue downstream through the river between dams. (C) 2015 Elsevier B.V. All rights reserved. C1 [Li, Xinya; Deng, Zhiqun D.; Martinez, Jayson J.; Fu, Tao] Pacific NW Natl Lab, Hydrol Grp, Richland, WA 99352 USA. [Titzler, P. Scott; Hughes, James S.; Weiland, Mark A.; Brown, Richard S.] Pacific NW Natl Lab, Ecol Grp, Richland, WA 99352 USA. [Trumbo, Bradly A.; Ahmann, Martin L.; Renholds, Jon F.] US Army Corps Engineers, Walla Walla, WA 99362 USA. RP Deng, ZD (reprint author), Pacific NW Natl Lab, Hydrol Grp, 3320 Innovat Blvd,POB 999, Richland, WA 99352 USA. EM zhiqun.deng@pnnl.gov RI Deng, Daniel/A-9536-2011 OI Deng, Daniel/0000-0002-8300-8766 FU U.S. Army Corps of Engineers (USACE) Walla Walla District FX This study was funded by the U.S. Army Corps of Engineers (USACE) Walla Walla District and conducted at Pacific Northwest National Laboratory (PNNL), which is operated by Battelle for the U.S. Department of Energy. We greatly appreciate the assistance of USACE staff members including Derek Fryer, Eric Hockersmith, Steve Juhnke, Marvin Shutters, and Tim Wik. We are also grateful to many staff of PNNL, Pacific States Marine Fisheries Commission, and the University of Washington for their technical help and field support. NR 25 TC 3 Z9 3 U1 11 U2 40 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-7836 EI 1872-6763 J9 FISH RES JI Fish Res. PD JUL PY 2015 VL 167 BP 216 EP 224 DI 10.1016/j.fishres.2015.01.018 PG 9 WC Fisheries SC Fisheries GA CH0VO UT WOS:000353740700025 ER PT J AU Vanhoy, JR Hicks, SF Chakraborty, A Champine, BR Combs, BM Crider, BP Kersting, LJ Kumar, A Lueck, CJ Liu, SH McDonough, PJ McEllistrem, MT Peters, EE Prados-Estevez, FM Sidwell, LC Sigillito, AJ Watts, DW Yates, SW AF Vanhoy, J. R. Hicks, S. F. Chakraborty, A. Champine, B. R. Combs, B. M. Crider, B. P. Kersting, L. J. Kumar, A. Lueck, C. J. Liu, S. H. McDonough, P. J. McEllistrem, M. T. Peters, E. E. Prados-Estevez, F. M. Sidwell, L. C. Sigillito, A. J. Watts, D. W. Yates, S. W. TI Neutron scattering differential cross sections for Na-23 from 1.5 to 4.5 MeV SO NUCLEAR PHYSICS A LA English DT Article DE Elastic and inelastic neutron scattering; Na-23(n,n); Na-23(n,n ') and (n,n 'gamma) cross sections; ECIS06 calculations ID ANGULAR-DISTRIBUTIONS; INELASTIC-SCATTERING; NUCLEAR-DYNAMICS; EXCITATIONS; SENSITIVITY; EFFICIENCY; DETECTOR; SYSTEM; PT-194 AB Measurements of neutron elastic and inelastic scattering cross sections from Na-23 have been performed for sixteen incident neutron energies between 1.5 and 4.5 MeV. These measurements were complemented by gamma-ray excitation functions using the (n, n'gamma) reaction to include excited levels not resolved in the neutron detection measurements. The time-of-flight (TOF) technique was employed for background reduction in both neutron and gamma-ray measurements and for energy determination in neutron detection measurements. Previous reaction model evaluations relied primarily on neutron total cross sections and four (n, n(0)) and (n, n(1)) angular distributions in the 5 to 9 MeV range. The inclusion of more inelastic channels and measurements at lower incident neutron energies provide additional information on direct couplings between elastic and inelastic scattering as a function of angular momentum transfer. Reaction model calculations examining collective direct-coupling and compound absorption components were performed. (C) 2015 Elsevier B.V. All rights reserved. C1 [Vanhoy, J. R.; Watts, D. W.] US Naval Acad, Dept Phys, Annapolis, MD 21402 USA. [Hicks, S. F.; Combs, B. M.; Kersting, L. J.; Lueck, C. J.; McDonough, P. J.; Sidwell, L. C.; Sigillito, A. J.] Univ Dallas, Dept Phys, Irving, TX 75062 USA. [Chakraborty, A.; Kumar, A.; Liu, S. H.; Peters, E. E.; Prados-Estevez, F. M.; Yates, S. W.] Univ Kentucky, Dept Chem, Lexington, KY 40506 USA. [Chakraborty, A.; Crider, B. P.; Kumar, A.; Liu, S. H.; McEllistrem, M. T.; Prados-Estevez, F. M.; Yates, S. W.] Univ Kentucky, Dept Phys & Astron, Lexington, KY 40506 USA. [Champine, B. R.] US Mil Acad, Dept Phys & Nucl Engn, West Point, NY 10996 USA. RP Vanhoy, JR (reprint author), US Naval Acad, Dept Phys, Annapolis, MD 21402 USA. EM vanhoy@usna.edu; hicks@udallas.edu RI Sigillito, Anthony/N-5981-2015 OI Sigillito, Anthony/0000-0002-4765-9414 FU U.S. Department of Energy Office of Science Nuclear Energy Universities Program [NU-12-KY-UK-0201-05]; U.S. National Science Foundation [PHY-1305801]; USMA Nuclear Science and Engineering Research Center; USNA James Kinnear Fellowship; Cowan Physics Fund at the University of Dallas FX Research at the University of Kentucky Accelerator Laboratory is supported by a contract from the U.S. Department of Energy Office of Science Nuclear Energy Universities Program award NU-12-KY-UK-0201-05, the U.S. National Science Foundation under grant PHY-1305801, the USMA Nuclear Science and Engineering Research Center, the USNA James Kinnear Fellowship, and the Cowan Physics Fund at the University of Dallas. The authors also acknowledge the many contributions of H.E. Baber to these measurements. NR 49 TC 3 Z9 3 U1 0 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0375-9474 EI 1873-1554 J9 NUCL PHYS A JI Nucl. Phys. A PD JUL PY 2015 VL 939 BP 121 EP 140 DI 10.1016/j.nuclphysa.2015.03.006 PG 20 WC Physics, Nuclear SC Physics GA CH1BF UT WOS:000353755400009 ER PT J AU West, BJ AF West, Bruce J. TI Exact solution to fractional logistic equation SO PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS LA English DT Article DE Fractional calculus; Logistic; Nonlinear; Exact solution AB The logistic equation is one of the most familiar nonlinear differential equations in the biological and social sciences. Herein we provide an exact solution to an extension of this equation to incorporate memory through the use of fractional derivatives in time. The solution to the fractional logistic equation (FLE) is obtained using the Carleman embedding technique that allows the nonlinear equation to be replaced by an infinite-order set of linear equations, which we then solve exactly. The formal series expansion for the initial value solution of the FLE is shown to be expressed in terms of a series of weighted Mittag-Leffler functions that reduces to the well known analytic solution in the limit where the fractional index for the derivative approaches unity. The numerical integration to the FLE provides an excellent fit to the analytic solution. We propose this approach as a general technique for solving a class of nonlinear fractional differential equations. Published by Elsevier B.V. C1 Army Res Off, Informat Sci Directorate, Res Triangle Pk, NC 27709 USA. RP West, BJ (reprint author), Army Res Off, Informat Sci Directorate, Res Triangle Pk, NC 27709 USA. EM bruce.j.west.civ@mail.mil FU Army Research Office FX The author thanks the Army Research Office for supporting this research and M. Turalska for supplying the figure. NR 20 TC 7 Z9 7 U1 1 U2 14 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-4371 EI 1873-2119 J9 PHYSICA A JI Physica A PD JUL 1 PY 2015 VL 429 BP 103 EP 108 DI 10.1016/j.physa.2015.02.073 PG 6 WC Physics, Multidisciplinary SC Physics GA CG2CJ UT WOS:000353082200011 ER PT J AU Price, SR Donohoe, JP Fairley, J AF Price, Steven R. Donohoe, J. Patrick Fairley, Josh TI Impacts of Wall-Target Interaction on Matched Illumination Waveforms for TWRI SO IEEE GEOSCIENCE AND REMOTE SENSING LETTERS LA English DT Article DE Computational electromagnetics; target detection; through-wall imaging; through-wall radar; through-wall waveform design; waveform design ID DESIGN; SYSTEM AB The impacts of wall-target interaction on matched illumination waveforms for through-the-wall radar imaging are examined via finite-difference time-domain simulation. Returns from various wall-target scenarios are considered as a function of the target-to-wall separation in order to examine the effectiveness of the so-called primary-wave target response in the matched illumination implementation. The primary-wave target response is shown to effectively maximize the signal-to-interference-and-noise ratio (SINR) in through-wall radar applications where the wall-target interaction is minor, and the primary-wave response closely resembles the full-wave target response, which contains all wall-target interactions. The ability of the primary-wave target response to maximize the SINR can be degraded by relatively minor errors in the wall-target transfer function caused by the incomplete wall-target physics inherent to the scheme. In such cases, the resulting matched illumination waveform spectrum is generally characterized by narrowband energy concentrated at suboptimal frequencies. C1 [Price, Steven R.; Donohoe, J. Patrick] Mississippi State Univ, Dept Elect & Comp Engn, Mississippi State, MS 39762 USA. [Fairley, Josh] US Army Geotech & Struct Lab, Vicksburg, MS 39180 USA. RP Price, SR (reprint author), Mississippi State Univ, Dept Elect & Comp Engn, Mississippi State, MS 39762 USA. EM sp391@msstate.edu; donohoe@ece.msstate.edu; Josh.Fairley@usace.army.mil NR 10 TC 1 Z9 1 U1 2 U2 6 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1545-598X EI 1558-0571 J9 IEEE GEOSCI REMOTE S JI IEEE Geosci. Remote Sens. Lett. PD JUL PY 2015 VL 12 IS 7 BP 1402 EP 1405 DI 10.1109/LGRS.2015.2403791 PG 4 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA CF5CI UT WOS:000352572600004 ER PT J AU Young, MD Field, JJ Sheetz, KE Bartels, RA Squier, J AF Young, Michael D. Field, Jeffrey J. Sheetz, Kraig E. Bartels, Randy A. Squier, Jeff TI A pragmatic guide to multiphoton microscope design SO ADVANCES IN OPTICS AND PHOTONICS LA English DT Article ID LASER-SCANNING MICROSCOPY; RAMAN-SCATTERING MICROSCOPY; EXCITATION FLUORESCENCE MICROSCOPY; TOTAL EMISSION DETECTION; 2-DIMENSIONAL NONIMAGING CONCENTRATORS; FEMTOSECOND YB-KGD(WO4)(2) LASER; MULTIFOCAL NONLINEAR MICROSCOPY; SPECTRAL PHASE INTERFEROMETRY; ELECTRIC-FIELD RECONSTRUCTION; PHOTON-COUNTING MICROSCOPY AB Multiphoton microscopy has emerged as a ubiquitous tool for studying microscopic structure and function across a broad range of disciplines. As such, the intent of this paper is to present a comprehensive resource for the construction and performance evaluation of a multiphoton microscope that will be understandable to the broad range of scientific fields that presently exploit, or wish to begin exploiting, this powerful technology. With this in mind, we have developed a guide to aid in the design of a multiphoton microscope. We discuss source selection, optical management of dispersion, image-relay systems with scan optics, objective-lens selection, single-element light-collection theory, photon-counting detection, image rendering, and finally, an illustrated guide for building an example microscope. (C) 2015 Optical Society of America C1 [Young, Michael D.; Squier, Jeff] Colorado Sch Mines, Dept Phys, Ctr Microintegrated Opt Adv Biol Control, Golden, CO 80401 USA. [Field, Jeffrey J.; Bartels, Randy A.] Colorado State Univ, WM Keck Lab Raman Imaging Cell To Cell Commun, Ft Collins, CO 80523 USA. [Field, Jeffrey J.; Bartels, Randy A.] Colorado State Univ, Dept Elect & Comp Engn, Ft Collins, CO 80523 USA. [Sheetz, Kraig E.] US Mil Acad, Photon Res Ctr, Dept Phys & Nucl Engn, West Point, NY 10996 USA. [Bartels, Randy A.] Colorado State Univ, Sch Biomed Engn, Ft Collins, CO 80523 USA. RP Young, MD (reprint author), Colorado Sch Mines, Dept Phys, Ctr Microintegrated Opt Adv Biol Control, 1500 Illinois St, Golden, CO 80401 USA. EM miyoung@mines.edu FU National Institute of Biomedical Imaging and Bioengineering under the Bioengineering Research Partnership [EB003832] FX This work was funded by the National Institute of Biomedical Imaging and Bioengineering under the Bioengineering Research Partnership EB003832. We acknowledge Yves Bellouard for supplying the specimens in Figs. 53-56, help in identifying the features with these specimens, and the annotation of Fig. 56. Jeffrey Field and Randy Bartels thank Stu Tobert for the generous donation of the murine tissue samples in Figs. 21, 58, and 59. The authors thank the reviewers for their time, helpful suggestions, and recommendations. NR 370 TC 3 Z9 3 U1 1 U2 31 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1943-8206 J9 ADV OPT PHOTONICS JI Adv. Opt. Photonics PD JUN 30 PY 2015 VL 7 IS 2 BP 276 EP 378 DI 10.1364/AOP.7.000276 PG 103 WC Optics SC Optics GA CM1RY UT WOS:000357459200004 PM 27182429 ER PT J AU Alvarez, LM Rivera, JJ Stockdale, L Saini, S Lee, RT Griffith, LG AF Alvarez, Luis M. Rivera, Jaime J. Stockdale, Linda Saini, Sunil Lee, Richard T. Griffith, Linda G. TI Tethering of Epidermal Growth Factor (EGF) to Beta Tricalcium Phosphate (beta TCP) via Fusion to a High Affinity, Multimeric beta TCP-Binding Peptide: Effects on Human Multipotent Stromal Cells/Connective Tissue Progenitors SO PLOS ONE LA English DT Article ID MESENCHYMAL STEM-CELLS; HUMAN BONE-MARROW; ACID-RICH SEQUENCES; IN-VIVO; FACTOR RECEPTOR; FILAMENTOUS BACTERIOPHAGE; HYDROXYAPATITE CRYSTALS; ADSORPTION PROTEIN; TITANIUM SURFACES; COLONY FORMATION AB Transplantation of freshly-aspirated autologous bone marrow, together with a scaffold, is a promising clinical alternative to harvest and transplantation of autologous bone for treatment of large defects. However, survival proliferation, and osteogenic differentiation of the marrow-resident stem and progenitor cells with osteogenic potential can be limited in large defects by the inflammatory microenvironment. Previous studies using EGF tethered to synthetic polymer substrates have demonstrated that surface-tethered EGF can protect human bone marrow-derived osteogenic stem and progenitor cells from pro-death inflammatory cues and enhance their proliferation without detriment to subsequent osteogenic differentiation. The objective of this study was to identify a facile means of tethering EGF to clinically-relevant beta TCP scaffolds and to demonstrate the bioactivity of EGF tethered to beta TCP using stimulation of the proliferative response of human bone-marrow derived mesenchymal stem cells (hBMSC) as a phenotypic metric. We used a phage display library and panned against beta TCP and composites of beta TCP with a degradable polyester biomaterial, together with orthogonal blocking schemes, to identify a 12-amino acid consensus binding peptide sequence, LLADTTHHRPWT, with high affinity for beta TCP. When a single copy of this beta TCP-binding peptide sequence was fused to EGF via a flexible peptide tether domain and expressed recombinantly in E. coli together with a maltose-binding domain to aid purification, the resulting fusion protein exhibited modest affinity for beta TCP. However, a fusion protein containing a linear concatamer containing 10 repeats of the binding motif the resulting fusion protein showed high affinity stable binding to beta TCP, with only 25% of the protein released after 7 days at 37 degrees C. The fusion protein was bioactive, as assessed by its abilities to activate kinase signaling pathways downstream of the EGF receptor when presented in soluble form, and to enhance the proliferation of hBMSC when presented in tethered form on commercial beta TCP bone regeneration scaffolds. C1 [Alvarez, Luis M.; Rivera, Jaime J.; Stockdale, Linda; Griffith, Linda G.] MIT, Dept Biol Engn, Cambridge, MA 02139 USA. [Saini, Sunil] Integra Life Sci, Plainsboro, NJ USA. [Lee, Richard T.] Harvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA. [Alvarez, Luis M.] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. [Alvarez, Luis M.] NCI, Canc & Dev Biol Lab, Frederick, MD 21701 USA. RP Griffith, LG (reprint author), MIT, Dept Biol Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA. EM griff@mit.edu FU NIH [R01DE019523, 1R01HL117986]; Armed Forces Institute for Regenerative Medicine (AFIRM); NIH Biotechnology Training Program [T32 GM008334]; Hertz Foundation FX Funding: Funding for this work was provided by NIH R01DE019523 (LGG), the Armed Forces Institute for Regenerative Medicine (AFIRM) (LGG), NIH Biotechnology Training Program T32 GM008334 fellowship (JR), NIH 1R01HL117986 (RTL), and a Hertz Foundation Pre-doctoral Fellowship (LMA). NR 94 TC 2 Z9 2 U1 3 U2 8 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUN 29 PY 2015 VL 10 IS 6 AR e0129600 DI 10.1371/journal.pone.0129600 PG 21 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CN1BL UT WOS:000358150400023 PM 26121597 ER PT J AU Nilsson, C Hejdeman, B Godoy-Ramirez, K Tecleab, T Scarlatti, G Brave, A Earl, PL Stout, RR Robb, ML Shattock, RJ Biberfeld, G Sandstrom, E Wahren, B AF Nilsson, Charlotta Hejdeman, Bo Godoy-Ramirez, Karina Tecleab, Teghesti Scarlatti, Gabriella Brove, Andreas Earl, Patricia L. Stout, Richard R. Robb, Merlin L. Shattock, Robin J. Biberfeld, Gunnel Sandstrom, Eric Wahren, Britta TI HIV-DNA Given with or without Intradermal Electroporation Is Safe and Highly Immunogenic in Healthy Swedish HIV-1 DNA/MVA Vaccinees: A Phase I Randomized Trial SO PLOS ONE LA English DT Article ID T-CELL RESPONSES; HUMORAL IMMUNE-RESPONSES; BOOST VACCINE; VIRUS ANKARA; VIVO ELECTROPORATION; RHESUS MACAQUES; BROAD; IMMUNIZATION; EXPRESSION; DELIVERY AB Background We compared safety and immunogenicity of intradermal (ID) vaccination with and without electroporation (EP) in a phase I randomized placebo-controlled trial of an HIV-DNA prime HIV-MVA boost vaccine in healthy Swedish volunteers. Methods HIV-DNA plasmids encoding HIV-1 genes gp160 subtypes A, B and C; Rev B; Gag A and B and RTmut B were given ID at weeks 0, 6 and 12 in a dose of 0.6 mg. Twenty-five volunteers received vaccine using a needle-free device (ZetaJet) with (n= 16) or without (n= 9) ID EP (Dermavax). Five volunteers were placebo recipients. Boosting with recombinant MVACMDR expressing HIV-1 Env, Gag, Pol of CRF01_AE (HIV-MVA) or placebo was performed at weeks 24 and 40. Nine of the vaccinees received a subtype C CN54 gp140 protein boost together with HIV-MVA. Results The ID/EP delivery was very well tolerated. After three HIV-DNA immunizations, no statistically significant difference was seen in the IFN-. ELISpot response rate to Gag between HIV-DNA ID/EP recipients (5/15, 33%) and HIV-DNA ID recipients (1/7, 14%, p= 0.6158). The first HIV-MVA or HIV-MVA+ gp140 vaccination increased the IFN-. ELISpot response rate to 18/19 (95%). CD4(+) and/or CD8(+) T cell responses to Gag or Env were demonstrable in 94% of vaccinees. A balanced CD4(+) and CD8(+) T cell response was noted, with 78% and 71% responders, respectively. IFN-. and IL-2 dominated the CD4+ T cell response to Gag and Env. The CD8(+) response to Gag was broader with expression of IFN-gamma, IL-2, MIP-1 beta and/or CD107. No differences were seen between DNA vaccine groups. Binding antibodies were induced after the second HIV-MVA+/-gp140 in 93% of vaccinees to subtype C Env, with the highest titers among EP/gp140 recipients. Conclusion Intradermal electroporation of HIV-DNA was well tolerated. Strong cell-and antibody-mediated immune responses were elicited by the HIV-DNA prime and HIV-MVA boosting regimen, with or without intradermal electroporation use. C1 [Nilsson, Charlotta; Godoy-Ramirez, Karina; Tecleab, Teghesti; Brove, Andreas; Biberfeld, Gunnel] Publ Hlth Agcy Sweden, Dept Microbiol, Solna, Sweden. [Nilsson, Charlotta; Biberfeld, Gunnel; Wahren, Britta] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden. [Nilsson, Charlotta] Karolinska Inst, Dept Lab Med, Huddinge, Sweden. [Hejdeman, Bo] Karolinska Inst, Dept Educ & Clin Res, Venhalsan, Stockholm, Sweden. [Scarlatti, Gabriella] IRCCS San Raffaele Sci Inst, Div Immunol Transplantat & Infect Dis, Viral Evolut & Transmiss Unit, Milan, Italy. [Earl, Patricia L.] NIAID, NIH, Bethesda, MD 20892 USA. [Stout, Richard R.] Bioject Inc, Tigard, OR USA. [Robb, Merlin L.] Walter Reed Army Inst Res, Mil HIV Res Program, Rockville, MD USA. [Shattock, Robin J.] Univ London Imperial Coll Sci Technol & Med, Dept Infect Dis, Div Med, London, England. RP Nilsson, C (reprint author), Publ Hlth Agcy Sweden, Dept Microbiol, Solna, Sweden. EM charlotta.nilsson@folkhalsomyndigheten.se FU Regional HIV/AIDS Team for Africa; Embassy of Sweden, Lusaka; Sweden and Norway [2150012801]; US Military HIV Research program; Walter Reed Army Institute of Research (WRAIR); Division of Intramural Research; NIAID; NIH FX This study was supported by The Regional HIV/AIDS Team for Africa, Embassy of Sweden, Lusaka, jointly funded by Sweden and Norway (Sida contribution number 2150012801). Additional support was provided by the US Military HIV Research program, Walter Reed Army Institute of Research (WRAIR) and the Division of Intramural Research, NIAID, NIH. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The views and opinions expressed herein do not necessarily reflect those of the U.S. Army or the department of Defense. NR 40 TC 4 Z9 4 U1 1 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUN 29 PY 2015 VL 10 IS 6 AR e0131748 DI 10.1371/journal.pone.0131748 PG 18 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CN1BL UT WOS:000358150400151 PM 26121679 ER PT J AU Dong, L Wang, J Namburu, R O'Regan, TP Dubey, M Dongare, AM AF Dong, Liang Wang, Jin Namburu, Raju O'Regan, Terrance P. Dubey, Madan Dongare, Avinash M. TI Edge effects on band gap energy in bilayer 2H-MoS2 under uniaxial strain SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID TRANSITION-METAL DICHALCOGENIDES; DENSITY-FUNCTIONAL THEORY; ATOMICALLY THIN MOS2; MAGNETIC-PROPERTIES; ELECTRONIC-PROPERTIES; NANORIBBONS; MONOLAYER; GRAPHENE; TRANSISTORS; NANOSHEETS AB The potential of ultrathin MoS2 nanostructures for applications in electronic and optoelectronic devices requires a fundamental understanding in their electronic structure as a function of strain. Previous experimental and theoretical studies assume that an identical strain and/or stress state is always maintained in the top and bottom layers of a bilayer MoS2 film. In this study, a bilayer MoS2 supercell is constructed differently from the prototypical unit cell in order to investigate the layer-dependent electronic band gap energy in a bilayer MoS2 film under uniaxial mechanical deformations. The supercell contains an MoS2 bottom layer and a relatively narrower top layer (nanoribbon with free edges) as a simplified model to simulate the as-grown bilayer MoS2 flakes with free edges observed experimentally. Our results show that the two layers have different band gap energies under a tensile uniaxial strain, although they remain mutually interacting by van der Waals interactions. The deviation in their band gap energies grows from 0 to 0.42 eV as the uniaxial strain increases from 0% to 6% under both uniaxial strain and stress conditions. The deviation, however, disappears if a compressive uniaxial strain is applied. These results demonstrate that tensile uniaxial strains applied to bilayer MoS2 films can result in distinct band gap energies in the bilayer structures. Such variations need to be accounted for when analyzing strain effects on electronic properties of bilayer or multilayered 2D materials using experimental methods or in continuum models. (C) 2015 AIP Publishing LLC. C1 [Dong, Liang; Wang, Jin; Dongare, Avinash M.] Univ Connecticut, Dept Mat Sci & Engn, Storrs, CT 06269 USA. [Dong, Liang; Wang, Jin; Dongare, Avinash M.] Univ Connecticut, Inst Mat Sci, Storrs, CT 06269 USA. [Namburu, Raju] US Army Res Lab, Computat & Informat Sci Directorate, Aberdeen Proving Ground, MD 21005 USA. [O'Regan, Terrance P.; Dubey, Madan] US Army Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. RP Dongare, AM (reprint author), Univ Connecticut, Dept Mat Sci & Engn, Storrs, CT 06269 USA. EM dongare@uconn.edu RI Dong, Liang/O-3439-2015 FU Army Research Laboratory [W911NF-14-2-0059]; U.S. Army Research Laboratory (ARL) Director's Strategic Initiative (DSI) FX Research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement No. W911NF-14-2-0059. The authors R. R. Namburu, T. P. O'Regan, and M. Dubey acknowledge the support of the U.S. Army Research Laboratory (ARL) Director's Strategic Initiative (DSI) program on interfaces in stacked 2D atomic layered materials. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 50 TC 5 Z9 5 U1 6 U2 52 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD JUN 28 PY 2015 VL 117 IS 24 AR 244303 DI 10.1063/1.4922811 PG 9 WC Physics, Applied SC Physics GA CM3VT UT WOS:000357613900028 ER PT J AU Sosanya, NM Cacheaux, LP Workman, ER Niere, F Perrone-Bizzozero, NI Raab-Graham, KF AF Sosanya, Natasha M. Cacheaux, Luisa P. Workman, Emily R. Niere, Farr Perrone-Bizzozero, Nora I. Raab-Graham, Kimberly F. TI Mammalian Target of Rapamycin (mTOR) Tagging Promotes Dendritic Branch Variability through the Capture of Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII) mRNAs by the RNA-binding Protein HuD SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article DE fluorescence; mammalian target of rapamycin (mTOR); mRNA decay; neuron; protein synthesis; RNA-binding protein; dendritic branch; in situ hybridization; synaptic tagging and capture; translational control ID LONG-TERM POTENTIATION; SYNAPTIC PLASTICITY; HIPPOCAMPAL-NEURONS; SIGNALING PATHWAY; CYTOPLASMIC POLYADENYLATION; UP-REGULATION; POLY(A) TAIL; GAP-43 GENE; MEMORY; TRANSLATION AB Background: Memory requires protein synthesis of dendritic CaMKII. Results: HuD directs CaMKII expression in a branch-specific manner. mTOR inhibition reduces HuD binding and promotes deadenylation of CaMKII mRNA. Conclusion: mTOR activity tags synapses, allowing HuD to capture CaMKII in a branch-specific manner. Significance: mTOR and HuD provide a molecular model for the synaptic tagging and capture hypothesis. The fate of a memory, whether stored or forgotten, is determined by the ability of an active or tagged synapse to undergo changes in synaptic efficacy requiring protein synthesis of plasticity-related proteins. A synapse can be tagged, but without the capture of plasticity-related proteins, it will not undergo long lasting forms of plasticity (synaptic tagging and capture hypothesis). What the tag is and how plasticity-related proteins are captured at tagged synapses are unknown. Ca2+/calmodulin-dependent protein kinase II (CaMKII) is critical in learning and memory and is synthesized locally in neuronal dendrites. The mechanistic (mammalian) target of rapamycin (mTOR) is a protein kinase that increases CaMKII protein expression; however, the mechanism and site of dendritic expression are unknown. Herein, we show that mTOR activity mediates the branch-specific expression of CaMKII, favoring one secondary, daughter branch over the other in a single neuron. mTOR inhibition decreased the dendritic levels of CaMKII protein and mRNA by shortening its poly(A) tail. Overexpression of the RNA-stabilizing protein HuD increased CaMKII protein levels and preserved its selective expression in one daughter branch over the other when mTOR was inhibited. Unexpectedly, deleting the third RNA recognition motif of HuD, the domain that binds the poly(A) tail, eliminated the branch-specific expression of CaMKII when mTOR was active. These results provide a model for one molecular mechanism that may underlie the synaptic tagging and capture hypothesis where mTOR is the tag, preventing deadenylation of CaMKII mRNA, whereas HuD captures and promotes its expression in a branch-specific manner. C1 [Sosanya, Natasha M.; Cacheaux, Luisa P.; Workman, Emily R.; Niere, Farr; Raab-Graham, Kimberly F.] Univ Texas Austin, Ctr Learning & Memory, Dept Neurosci, Austin, TX 78712 USA. [Sosanya, Natasha M.; Raab-Graham, Kimberly F.] Univ Texas Austin, Inst Cell Biol, Austin, TX 78712 USA. [Workman, Emily R.; Raab-Graham, Kimberly F.] Univ Texas Austin, Inst Neurosci, Austin, TX 78712 USA. [Sosanya, Natasha M.] US Army Inst Surg Res, Joint Base San Antonio Ft Sam, Houston, TX 78234 USA. [Perrone-Bizzozero, Nora I.] Univ New Mexico, Hlth Sci Ctr, Dept Neurosci Psychiat & Behav Sci, Albuquerque, NM 87131 USA. RP Raab-Graham, KF (reprint author), Univ Texas Austin, Ctr Learning & Memory, Dept Neurosci, 1 Univ Stn,C7000, Austin, TX 78712 USA. EM Kimberly@mail.clm.utexas.edu RI Regan, Clinton/E-6250-2012 FU National Science Foundation (NSF) [IOS 1026527, IOS 1355158]; National Institutes of Health [R01 NS30255, DA034897]; NSF Postdoctoral Research Fellowship in Biology [DBI-1103738, DBI-1306528] FX This work was supported by National Science Foundation (NSF) Grants IOS 1026527 and IOS 1355158 (to K. F. R.-G.) and by National Institutes of Health Grants R01 NS30255 and DA034897 (to N. I. P.-B.). The authors declare that they have no conflicts of interest with the contents of this article.; Supported by NSF Postdoctoral Research Fellowship in Biology DBI-1103738.; Supported by NSF Postdoctoral Research Fellowship in Biology DBI-1306528. NR 48 TC 10 Z9 10 U1 0 U2 5 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA SN 0021-9258 EI 1083-351X J9 J BIOL CHEM JI J. Biol. Chem. PD JUN 26 PY 2015 VL 290 IS 26 BP 16357 EP 16371 DI 10.1074/jbc.M114.599399 PG 15 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA CL4NR UT WOS:000356930100037 PM 25944900 ER PT J AU George, A Phillips, M Sweeney, L Colombo, C AF George, Amaya Phillips, Michael Sweeney, Lori Colombo, Christopher TI CASE REVIEW A 56 year old woman with syncope, weakness, and refractory hypotension SO BMJ-BRITISH MEDICAL JOURNAL LA English DT Editorial Material C1 [George, Amaya] Dwight D Eisenhower Army Med Ctr, Dept Internal Med, Ft Gordon, GA 30905 USA. [Phillips, Michael] Brooke Army Med Ctr, Dept Cardiol, Ft Sam Houston, TX 78234 USA. [Sweeney, Lori] Virginia Commonwealth Univ Hlth Syst, Dept Endocrinol, Richmond, VA USA. [Colombo, Christopher] Dwight D Eisenhower Army Med Ctr, Dept Crit Care, Ft Gordon, GA USA. RP George, A (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Internal Med, Ft Gordon, GA 30905 USA. EM amaya.d.george.mil@mail.mil NR 5 TC 0 Z9 0 U1 1 U2 2 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1756-1833 J9 BMJ-BRIT MED J JI BMJ-British Medical Journal PD JUN 25 PY 2015 VL 350 AR h3387 DI 10.1136/bmj.h3387 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA CL7OB UT WOS:000357160500003 PM 26113625 ER PT J AU Darling, KA Huskins, EL Schuster, BE Wei, Q Kecskes, LJ AF Darling, K. A. Huskins, E. L. Schuster, B. E. Wei, Q. Kecskes, L. J. TI Mechanical properties of a high strength Cu-Ta composite at elevated temperature SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE Nanocrystalline alloys; CU-Ta alloys; Thermal-strain rate effect; Dynamic compression test ID BINARY NANOCRYSTALLINE ALLOYS; MOLECULAR-DYNAMICS SIMULATIONS; SEVERE PLASTIC-DEFORMATION; GRAIN-GROWTH; THERMAL-STABILITY; THIN-FILMS; THERMOKINETIC DESCRIPTION; THERMODYNAMIC STABILITY; MICROSTRUCTURAL STABILITY; ELECTRICAL-PROPERTIES AB Nominally pure nanocrystalline metals do not remain nanostructured under extreme conditions of intense heating and or deformation preventing the study of their physical response under such conditions. Here we present the coupled effect of temperature and strain rate on the mechanical response of a thermally stabilized nanocrystalline Cu alloyed with 10 at% Ta. Compressive mechanical testing was performed from 24 to 1000 degrees C and strain rates ranging from,quasi-static (10(-1) s(-1)) to dynamic (10(4) s(-1)) rates. The response of this material exhibits a maximum quasi-static yield stress of 1.05 GPa at room temperature and an approximate yield stress of 0.5 GPa at 600 degrees C, with an apparently linear temperature response. In contrast to pure coarse-grained Cu, our assessment indicates that this Cu-based composite derives its properties from a combination of very small Cu-rich grains and well-dispersed Ta clusters and nanometer ( < 10 nm) size Ta precipitates. Such microstructural features translate into a strong resistance to coarsening even after extensive exposure to elevated temperatures and high rates of deformation. Published by Elsevier B.V. C1 [Darling, K. A.; Huskins, E. L.; Schuster, B. E.; Kecskes, L. J.] US Army Res Lab, Weap & Mat Res Directorate, RDRL WMM F, Aberdeen Proving Ground, MD 21005 USA. [Wei, Q.] Univ N Carolina, Dept Mech Engn & Engn Sci, Charlotte, NC 28223 USA. RP Darling, KA (reprint author), US Army Res Lab, Weap & Mat Res Directorate, RDRL WMM F, Aberdeen Proving Ground, MD 21005 USA. EM Kristopher.darling.civ@mail.mil RI Wei, Qiuming/B-7579-2008 NR 75 TC 6 Z9 6 U1 6 U2 29 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 EI 1873-4936 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD JUN 25 PY 2015 VL 638 BP 322 EP 328 DI 10.1016/j.msea.2015.04.069 PG 7 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA CL1WK UT WOS:000356735400038 ER PT J AU Yeh, IC Andzelm, JW Rutledge, GC AF Yeh, In-Chul Andzelm, Jan W. Rutledge, Gregory C. TI Mechanical and Structural Characterization of Semicrystalline Polyethylene under Tensile Deformation by Molecular Dynamics Simulations SO MACROMOLECULES LA English DT Article ID HIGH-DENSITY POLYETHYLENE; PLASTIC-DEFORMATION; AMORPHOUS POLYMERS; WEIGHT POLYETHYLENE; YIELD-STRESS; CHAIN; CRYSTALLINE; CAVITATION; MELTS; ENTANGLEMENT AB We have studied tensile deformations of semicrystalline polyethylene (PE) with molecular dynamics simulations at two different strain rates and temperatures. Compared to earlier studies, the modeled systems were approximately 5 times larger, which allowed significantly larger strains up to about 120% to be examined. Two different modes of structural transformation of semicrystalline PE were observed at the higher temperature of 350 K, depending on the strain rate. At the faster strain rate of 5 x 10(7) s(-1), cavitation in the noncrystalline region dominated, with little change in the crystalline region, resulting in monotonically declining stress with increasing strain after the yield point. However, in a small number of cases, significant deviations from the average stress strain profile were observed that correlated with topological constraints, such as bridges and bridging entanglements connecting crystalline regions separated by the noncrystalline region, and destabilization of the crystalline region. At the slower strain rate of 5 x 10(6) s(-1), we observed repeated melting/recrystallization events and significant oscillations in stress associated with variations of density in crystalline and noncrystalline regions and the displacement of polymer chains from crystalline to noncrystalline regions. When averaged over an ensemble of starting configurations for semicrystalline PE, the oscillations were found to be less coherent from microstate to microstate and offset one another. The postyield stress became notably smoother and began to resemble the plastic flow observed macroscopically, followed by stress hardening at the later stage of deformation. At the lower temperature of 250 K, cavity formation was the only mechanism observed, for both strain rates. The interplay between the thermodynamic stability of the crystalline region and the topological constraints imposed by bridges and entanglements in the noncrystalline region is crucial to understanding structural transformations of semicrystalline PE during tensile deformations. C1 [Yeh, In-Chul; Andzelm, Jan W.] US Army Res Lab, Macromol Sci & Technol Branch, Mat & Mfg Sci Div, Aberdeen Proving Ground, MD 21005 USA. [Rutledge, Gregory C.] MIT, Dept Chem Engn, Cambridge, MA 02139 USA. RP Andzelm, JW (reprint author), US Army Res Lab, Macromol Sci & Technol Branch, Mat & Mfg Sci Div, Aberdeen Proving Ground, MD 21005 USA. EM jan.w.andzelm.civ@mail.mil; rutledge@mit.edu FU U.S. Army Research Laboratory (ARL); DoD HPC Modernization Office FX This work was supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Research Laboratory (ARL) administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and ARL. The DoD HPC Modernization Office supported this project by supplying supercomputer time under the Computing Challenge Project C5M. We thank Drs. Mark O. Robbins, Pieter in 't Veld, Jun Mo Kim, Rebeca Locker, and B. Christopher Rinderspacher for helpful discussions and comments. NR 43 TC 13 Z9 13 U1 3 U2 37 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0024-9297 EI 1520-5835 J9 MACROMOLECULES JI Macromolecules PD JUN 23 PY 2015 VL 48 IS 12 BP 4228 EP 4239 DI 10.1021/acs.macromol.5b00697 PG 12 WC Polymer Science SC Polymer Science GA CL5GV UT WOS:000356988700048 ER PT J AU Knorr, DB Masser, KA Elder, RM Sirk, TW Hindenlang, MD Yu, JH Richardson, AD Boyd, SE Spurgeon, WA Lenhart, JL AF Knorr, Daniel B., Jr. Masser, Kevin A. Elder, Robert M. Sirk, Timothy W. Hindenlang, Mark D. Yu, Jian H. Richardson, Adam D. Boyd, Steven E. Spurgeon, William A. Lenhart, Joseph L. TI Overcoming the structural versus energy dissipation trade-off in highly crosslinked polymer networks: Ultrahigh strain rate response in polydicyclopentadiene SO COMPOSITES SCIENCE AND TECHNOLOGY LA English DT Article DE Polymers; Amorphous materials; Fracture toughness; Matrix cracking; Impact behavior ID OPENING METATHESIS POLYMERIZATION; EPOXY-RESINS; MOLECULAR SIMULATION; MECHANICAL-BEHAVIOR; GLASS-TRANSITION; BALLISTIC IMPACT; COMPOSITES; ABSORPTION; DICYCLOPENTADIENE; DYNAMICS AB Ballistic performance, at effective strain rates of (10(4)-10(5) s(-1)), for polymeric dicyclopentadiene (pDCPD) was compared with two epoxy resin/diamine systems with comparable glass transition temperatures. The high rate response was characterized in terms of a projectile penetration kinetic energy, KE50, which describes the projectile kinetic energy at a velocity with a 50% probability of sample penetration. pDCPD showed superior penetration resistance, with a 300-400% improvement in ballistic energy dissipation, when compared with the structural epoxy resins. In addition, unlike typical highly crosslinked networks that become brittle at low temperatures, the improved pDCPD performance occurred over a very broad temperature range (-55 to 75 degrees C), despite exhibiting a glass transition temperature characteristic of structural resins (similar to 142 degrees C). In addition to the high T-g, pDCPD exhibited a room temperature glassy storage modulus of 1.7 GPa, offering the potential to circumvent the common structural versus energy dissipation trade-off encountered with conventional crosslinked polymers. Quasi-static measurements suggested that the performance of pDCPD is phenomenologically related to higher fracture toughness and lower yield stress relative to typical epoxies, while molecular dynamics simulations suggest the origin is the lack of strong non-covalent interactions and the facile formation of nanoscale voids to accommodate strain in pDCPD. Published by Elsevier Ltd. C1 [Knorr, Daniel B., Jr.; Masser, Kevin A.; Elder, Robert M.; Sirk, Timothy W.; Hindenlang, Mark D.; Yu, Jian H.; Richardson, Adam D.; Boyd, Steven E.; Spurgeon, William A.; Lenhart, Joseph L.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Lenhart, JL (reprint author), US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM joseph.l.lenhart.civ@mail.mil RI Elder, Robert/H-9886-2016 FU U.S. Army Research Laboratory FX Funding for this work was provided by the U.S. Army Research Laboratory. This work was supported by grants of computer time from the DOD High Performance Computing Modernization Program at the U.S. Air Force Research Laboratory and U.S. Army Engineer Research and Development Center DoD Supercomputing Resource Centers. NR 38 TC 8 Z9 8 U1 5 U2 28 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0266-3538 EI 1879-1050 J9 COMPOS SCI TECHNOL JI Compos. Sci. Technol. PD JUN 19 PY 2015 VL 114 BP 17 EP 25 DI 10.1016/j.compscitech.2015.03.021 PG 9 WC Materials Science, Composites SC Materials Science GA CK3NT UT WOS:000356123500003 ER PT J AU Gibson, DB AF Gibson, Douglas Brandt TI Effect size as the essential statistic in developing methods for mTBI diagnosis SO FRONTIERS IN NEUROLOGY LA English DT Review DE traumatic brain injury; classical measurement theory; effect size; MACE ID CONCUSSION AB The descriptive statistic known as "effect size" measures the distinguishability of two sets of data. Distingishability is at the core of diagnosis. This article is intended to point out the importance of effect size in the development of effective diagnostics for mild traumatic brain injury and to point out the applicability of the effect size statistic in comparing diagnostic efficiency across the main proposed TBI diagnostic methods: psychological, physiological, biochemical, and radiologic. Comparing diagnostic approaches is difficult because different researcher in different fields have different approaches to measuring efficacy. Converting diverse measures to effect sizes, as is done in meta-analysis, is a relatively easy way to make studies comparable. C1 US Army Res Inst, Programs Budget & Strategies Off, Ft Belvoir, VA 22060 USA. RP Gibson, DB (reprint author), US Army Res Inst, Programs Budget & Strategies Off, 6000 6th St,Bldg 1464, Ft Belvoir, VA 22060 USA. EM dglsbgbsn@yahoo.com NR 13 TC 1 Z9 1 U1 0 U2 1 PU FRONTIERS MEDIA SA PI LAUSANNE PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLAND SN 1664-2295 J9 FRONT NEUROL JI Front. Neurol. PD JUN 18 PY 2015 VL 6 AR UNSP 126 DI 10.3389/fneur.2015.00126 PG 5 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA CU9FJ UT WOS:000363849300001 PM 26150801 ER PT J AU Park, DJ Dudas, G Wohl, S Goba, A Whitmer, SLM Andersen, KG Sealfon, RS Ladner, JT Kugelman, JR Matranga, CB Winnicki, SM Qu, J Gire, SK Gladden-Young, A Jalloh, S Nosamiefan, D Yozwiak, NL Moses, LM Jiang, PP Lin, AE Schaffner, SF Bird, B Towner, J Mamoh, M Gbakie, M Kanneh, L Kargbo, D Massally, JLB Kamara, FK Konuwa, E Sellu, J Jalloh, AA Mustapha, I Foday, M Yillah, M Erickson, BR Sealy, T Blau, D Paddock, C Brault, A Amman, B Basile, J Bearden, S Belser, J Bergeron, E Campbell, S Chakrabarti, A Dodd, K Flint, M Gibbons, A Goodman, C Klena, J McMullan, L Morgan, L Russell, B Salzer, J Sanchez, A Wang, D Jungreis, I Tomkins-Tinch, C Kislyuk, A Lin, MF Chapman, S MacInnis, B Matthews, A Bochicchio, J Hensley, LE Kuhn, JH Nusbaum, C Schieffelin, JS Birren, BW Forget, M Nichol, ST Palacios, GF Ndiaye, D Happi, C Gevao, SM Vandi, MA Kargbo, B Holmes, EC Bedford, T Gnirke, A Stroher, U Rambaut, A Garry, RF Sabeti, PC AF Park, Daniel J. Dudas, Gytis Wohl, Shirlee Goba, Augustine Whitmer, Shannon L. M. Andersen, Kristian G. Sealfon, Rachel S. Ladner, Jason T. Kugelman, Jeffrey R. Matranga, Christian B. Winnicki, Sarah M. Qu, James Gire, Stephen K. Gladden-Young, Adrianne Jalloh, Simbirie Nosamiefan, Dolo Yozwiak, Nathan L. Moses, Lina M. Jiang, Pan-Pan Lin, Aaron E. Schaffner, Stephen F. Bird, Brian Towner, Jonathan Mamoh, Mambu Gbakie, Michael Kanneh, Lansana Kargbo, David Massally, James L. B. Kamara, Fatima K. Konuwa, Edwin Sellu, Josephine Jalloh, Abdul A. Mustapha, Ibrahim Foday, Momoh Yillah, Mohamed Erickson, Bobbie R. Sealy, Tara Blau, Dianna Paddock, Christopher Brault, Aaron Amman, Brian Basile, Jane Bearden, Scott Belser, Jessica Bergeron, Eric Campbell, Shelley Chakrabarti, Ayan Dodd, Kimberly Flint, Mike Gibbons, Aridth Goodman, Christin Klena, John McMullan, Laura Morgan, Laura Russell, Brandy Salzer, Johanna Sanchez, Angela Wang, David Jungreis, Irwin Tomkins-Tinch, Christopher Kislyuk, Andrey Lin, Michael F. Chapman, Sinead MacInnis, Bronwyn Matthews, Ashley Bochicchio, James Hensley, Lisa E. Kuhn, Jens H. Nusbaum, Chad Schieffelin, John S. Birren, Bruce W. Forget, Marc Nichol, Stuart T. Palacios, Gustavo F. Ndiaye, Daouda Happi, Christian Gevao, Sahr M. Vandi, Mohamed A. Kargbo, Brima Holmes, Edward C. Bedford, Trevor Gnirke, Andreas Stroeher, Ute Rambaut, Andrew Garry, Robert F. Sabeti, Pardis C. TI Ebola Virus Epidemiology, Transmission, and Evolution during Seven Months in Sierra Leone SO CELL LA English DT Article ID RNA VIRUSES; SELECTION; OUTBREAK; DATABASE AB The 2013-2015 Ebola virus disease (EVD) epidemic is caused by the Makona variant of Ebola virus (EBOV). Early in the epidemic, genome sequencing provided insights into virus evolution and transmission and offered important information for outbreak response. Here, we analyze sequences from 232 patients sampled over 7 months in Sierra Leone, along with 86 previously released genomes from earlier in the epidemic. We confirm sustained human-to-human transmission within Sierra Leone and find no evidence for import or export of EBOV across national borders after its initial introduction. Using high-depth replicate sequencing, we observe both host-to-host transmission and recurrent emergence of intrahost genetic variants. We trace the increasing impact of purifying selection in suppressing the accumulation of nonsynonymous mutations over time. Finally, we note changes in the mucin-like domain of EBOV glycoprotein that merit further investigation. These findings clarify the movement of EBOV within the region and describe viral evolution during prolonged human-to-human transmission. C1 [Park, Daniel J.; Wohl, Shirlee; Sealfon, Rachel S.; Matranga, Christian B.; Winnicki, Sarah M.; Qu, James; Gire, Stephen K.; Gladden-Young, Adrianne; Nosamiefan, Dolo; Yozwiak, Nathan L.; Jiang, Pan-Pan; Lin, Aaron E.; Schaffner, Stephen F.; Tomkins-Tinch, Christopher; Chapman, Sinead; MacInnis, Bronwyn; Matthews, Ashley; Bochicchio, James; Nusbaum, Chad; Birren, Bruce W.; Gnirke, Andreas; Sabeti, Pardis C.] Broad Inst Harvard & MIT, Cambridge, MA 02142 USA. [Dudas, Gytis; Rambaut, Andrew] Univ Edinburgh, Inst Evolutionary Biol, Ashworth Labs, Edinburgh EH9 3FL, Midlothian, Scotland. [Wohl, Shirlee; Winnicki, Sarah M.; Gire, Stephen K.; Yozwiak, Nathan L.; Jiang, Pan-Pan; Lin, Aaron E.; Schaffner, Stephen F.; Matthews, Ashley] Harvard Univ, Cambridge, MA 02138 USA. [Goba, Augustine; Jalloh, Simbirie; Mamoh, Mambu; Gbakie, Michael; Kanneh, Lansana; Kargbo, David; Massally, James L. B.; Kamara, Fatima K.; Konuwa, Edwin; Sellu, Josephine; Jalloh, Abdul A.; Mustapha, Ibrahim; Foday, Momoh; Yillah, Mohamed] Kenema Govt Hosp, Kenema, Sierra Leone. [Whitmer, Shannon L. M.; Bird, Brian; Towner, Jonathan; Erickson, Bobbie R.; Sealy, Tara; Blau, Dianna; Paddock, Christopher; Brault, Aaron; Amman, Brian; Basile, Jane; Bearden, Scott; Belser, Jessica; Bergeron, Eric; Campbell, Shelley; Chakrabarti, Ayan; Dodd, Kimberly; Flint, Mike; Gibbons, Aridth; Goodman, Christin; Klena, John; McMullan, Laura; Morgan, Laura; Russell, Brandy; Salzer, Johanna; Sanchez, Angela; Wang, David; Nichol, Stuart T.; Stroeher, Ute] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [Whitmer, Shannon L. M.; Bird, Brian; Towner, Jonathan; Erickson, Bobbie R.; Sealy, Tara; Blau, Dianna; Paddock, Christopher; Brault, Aaron; Amman, Brian; Basile, Jane; Bearden, Scott; Belser, Jessica; Bergeron, Eric; Campbell, Shelley; Chakrabarti, Ayan; Dodd, Kimberly; Flint, Mike; Gibbons, Aridth; Goodman, Christin; Klena, John; McMullan, Laura; Morgan, Laura; Russell, Brandy; Salzer, Johanna; Sanchez, Angela; Wang, David; Nichol, Stuart T.; Stroeher, Ute] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Andersen, Kristian G.] Scripps Res Inst, Scripps Translat Sci Inst, La Jolla, CA 92037 USA. [Sealfon, Rachel S.; Jungreis, Irwin] MIT, Cambridge, MA 02139 USA. [Ladner, Jason T.; Kugelman, Jeffrey R.; Palacios, Gustavo F.] US Army, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Moses, Lina M.; Schieffelin, John S.; Garry, Robert F.] Tulane Univ, New Orleans, LA 70112 USA. [Kislyuk, Andrey; Lin, Michael F.] DNAnexus, Mountain View, CA 94040 USA. [Hensley, Lisa E.; Kuhn, Jens H.] NIAID, Integrated Res Facil Ft Detrick, Div Clin Res, NIH, Frederick, MD 21702 USA. [Forget, Marc] Med Sans Frontieres, B-1050 Brussels, Belgium. [Ndiaye, Daouda] Univ Cheikh Anta Diop, Dakar, Senegal. [Happi, Christian] Redeemers Univ Nigeria, Redemption City, Ogun State, Nigeria. [Gevao, Sahr M.] Univ Sierra Leone, Freetown, Sierra Leone. [Vandi, Mohamed A.; Kargbo, Brima] Sierra Leone Minist Hlth & Sanitat, Freetown, Sierra Leone. [Holmes, Edward C.] Univ Sydney, Johns Hopkins Dr, Camperdown, NSW 2050, Australia. [Bedford, Trevor] Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA. [Rambaut, Andrew] Univ Edinburgh, Ctr Immunol Infect & Evolut, Ashworth Labs, Edinburgh EH9 3FL, Midlothian, Scotland. [Rambaut, Andrew] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. RP Park, DJ (reprint author), Broad Inst Harvard & MIT, 75 Ames St, Cambridge, MA 02142 USA. EM dpark@broadinstitute.org; a.rambaut@ed.ac.uk; pardis@broadinstitute.org RI Palacios, Gustavo/I-7773-2015; Schaffner, Stephen/D-1189-2011; OI Palacios, Gustavo/0000-0001-5062-1938; Flint, Michael/0000-0002-5373-787X; Dudas, Gytis/0000-0002-0227-4158; Tomkins-Tinch, Christopher/0000-0002-9114-6421; Holmes, Edward/0000-0001-9596-3552 FU European Union grant FP7 [278433-PREDEMICS]; European Research Council [260864]; Natural Environment Research Council [D76739X]; NIH [U54 GM111274, GM080177, 1U01HG007480-01]; National Science Foundation Graduate Research Fellowship [DGE 1144152]; National Health and Medical Research Council, Australia; Defense Threat Reduction Agency (USAMRIID); NIH/NIAID (Broad Institute) [U19AI110818]; Bill and Melinda Gates Foundation (Broad Institute) [OPP1123407]; US National Institute of Allergy and Infectious Diseases (NIAID) [HHSN272200700016I]; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services [HHSN272201400028C]; NIAID (Harvard/Tulane) [HHSN272200900049C]; Zalgen Labs FX This work was supported by European Union grant FP7/2007-2013 278433-PREDEMICS and European Research Council grant 260864 (A.R.); Natural Environment Research Council grant D76739X (G.D.); NIH U54 GM111274 (T.B.); NIH grant GM080177 (S.W.); NIH grant 1U01HG007480-01 (C.H.); National Science Foundation Graduate Research Fellowship Grant No. DGE 1144152 (A.E.L.); the National Health and Medical Research Council, Australia (E.C.H.); the Defense Threat Reduction Agency (USAMRIID); NIH/NIAID U19AI110818 (Broad Institute); the Bill and Melinda Gates Foundation OPP1123407 (Broad Institute); and NIAID HHSN272200900049C (Harvard/Tulane). This work was funded, in part, through Battelle Memorial Institute's prime contract with the US National Institute of Allergy and Infectious Diseases (NIAID) under contract number HHSN272200700016I. Subcontractors to Battelle Memorial Institute who performed this work are: J.H.K., an employee of Tunnell Government Services, Inc. R.F.G. is co-founder of Zalgen Labs.; The Virus Pathogen Database and Analysis Resource (ViPR) has been wholly funded with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under contract number HHSN272201400028C. NR 30 TC 65 Z9 67 U1 7 U2 75 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 0092-8674 EI 1097-4172 J9 CELL JI Cell PD JUN 18 PY 2015 VL 161 IS 7 BP 1516 EP 1526 DI 10.1016/j.cell.2015.06.007 PG 11 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA CL0GG UT WOS:000356618200010 PM 26091036 ER PT J AU Cheng, X Marcus, D Van Horn, JD Luo, Q Mattay, VS Weinberger, DR AF Cheng, Xi Marcus, Daniel Van Horn, John D. Luo, Qian Mattay, Venkata S. Weinberger, Daniel R. TI Going beyond the current neuroinformatics infrastructure SO FRONTIERS IN NEUROINFORMATICS LA English DT Editorial Material DE neuroinformatics; infrastructure; neuroscience; informatics; data sharing ID NEUROIMAGING-DATA; VISUALIZATION; BRAIN; NEUROSCIENCE; FRAMEWORK; SOFTWARE; GENETICS; PLATFORM; TOOLS; ELECTROPHYSIOLOGY C1 [Cheng, Xi; Mattay, Venkata S.; Weinberger, Daniel R.] Lieber Inst Brain Dev, Johns Hopkins Med Campus, Baltimore, MD USA. [Marcus, Daniel] Washington Univ, Sch Med, Dept Radiol, St Louis, MO 63110 USA. [Van Horn, John D.] Univ So Calif, Dept Neurol, Inst Neuroimaging & Informat, Lab Neuro Imaging, Los Angeles, CA USA. [Luo, Qian] Walter Reed Army Res Inst, Ctr Mil Psychiat & Neurosci Res, Silver Spring, MD USA. RP Cheng, X (reprint author), Lieber Inst Brain Dev, Johns Hopkins Med Campus, Baltimore, MD USA. EM chengxi001@gmail.com NR 38 TC 1 Z9 1 U1 3 U2 7 PU FRONTIERS MEDIA SA PI LAUSANNE PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLAND SN 1662-5196 J9 FRONT NEUROINFORM JI Front. Neuroinformatics PD JUN 16 PY 2015 VL 9 AR 15 DI 10.3389/fninf.2015.00015 PG 3 WC Mathematical & Computational Biology; Neurosciences SC Mathematical & Computational Biology; Neurosciences & Neurology GA DE4ND UT WOS:000370605600001 PM 26136680 ER PT J AU Ricker, R Hendricks, S Perovich, DK Helm, V Gerdes, R AF Ricker, Robert Hendricks, Stefan Perovich, Donald K. Helm, Veit Gerdes, Ruediger TI Impact of snow accumulation on CryoSat-2 range retrievals over Arctic sea ice: An observational approach with buoy data SO GEOPHYSICAL RESEARCH LETTERS LA English DT Article DE sea ice freeboard; sea ice thickness; CryoSat-2; snow depth; ice mass balance; radar altimetry ID MICROWAVE-FREQUENCIES; THICKNESS; FREEBOARD; COVER; CLIMATE; GROWTH AB Radar altimetry measurements of the current satellite mission CryoSat-2 show an increase of Arctic sea ice thickness in autumn 2013, compared to previous years but also related to March 2013. Such an increase over the melting season seems unlikely and needs to be investigated. Recent studies show that the influence of the snow cover is not negligible and can highly affect the CryoSat-2 range retrievals if it is assumed that the main scattering horizon is given by the snow-ice interface. Our analysis of Arctic ice mass balance buoy records and coincident CryoSat-2 data between 2012 and 2014 adds observational evidence to these findings. Linear trends of snow and ice freeboard measurements from buoys and nearby CryoSat-2 freeboard retrievals are calculated during accumulation events. We find a positive correlation between buoy snow freeboard and CryoSat-2 freeboard estimates, revealing that early snow accumulation might have caused a bias in CryoSat-2 sea ice thickness in autumn 2013. C1 [Ricker, Robert; Hendricks, Stefan; Helm, Veit; Gerdes, Ruediger] Helmholtz Ctr Polar & Marine Res, Alfred Wegener Inst, Bremerhaven, Germany. [Perovich, Donald K.] US Army Cold Reg Res & Engn Lab, Hanover, NH USA. RP Ricker, R (reprint author), Helmholtz Ctr Polar & Marine Res, Alfred Wegener Inst, Bremerhaven, Germany. EM robert.ricker@awi.de RI Ricker, Robert/H-8874-2016; Hendricks, Stefan/D-5168-2011 OI Ricker, Robert/0000-0001-6928-7757; Hendricks, Stefan/0000-0002-1412-3146 FU German Federal Ministry of Economics and Technology [50EE1008] FX Ice mass balance buoy data are provided by the Cold Regions Research and Engineering Laboratory (CRREL). CryoSat-2 data are provided by the European Space Agency (ESA). The work of S. Hendricks and V. Helm was funded by the German Federal Ministry of Economics and Technology (grant 50EE1008). All this is gratefully acknowledged. Thanks also to Marcel Nicolaus and Sandra Schwegmann for their input. NR 30 TC 6 Z9 6 U1 1 U2 11 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0094-8276 EI 1944-8007 J9 GEOPHYS RES LETT JI Geophys. Res. Lett. PD JUN 16 PY 2015 VL 42 IS 11 BP 4447 EP 4455 DI 10.1002/2015GL064081 PG 9 WC Geosciences, Multidisciplinary SC Geology GA CM2LI UT WOS:000357511200025 ER PT J AU Stewart, IJ Glass, KR Howard, JT Morrow, BD Sosnov, JA Siew, ED Wickersham, N Latack, W Kwan, HK Heegard, KD Diaz, C Henderson, AT Saenz, KK Ikizler, TA Chung, KK AF Stewart, Ian J. Glass, Kristen R. Howard, Jeffrey T. Morrow, Benjamin D. Sosnov, Jonathan A. Siew, Edward D. Wickersham, Nancy Latack, Wayne Kwan, Hana K. Heegard, Kelly D. Diaz, Christina Henderson, Aaron T. Saenz, Kristin K. Ikizler, T. Alp Chung, Kevin K. TI The potential utility of urinary biomarkers for risk prediction in combat casualties: a prospective observational cohort study SO CRITICAL CARE LA English DT Article ID ACUTE KIDNEY INJURY; GELATINASE-ASSOCIATED LIPOCALIN; CARDIAC-SURGERY; CRITICALLY-ILL; CYSTATIN-C; OUTCOMES; TRAUMA; MORTALITY; FAILURE; SCORE AB Introduction: Traditional risk scoring prediction models for trauma use either anatomically based estimations of injury or presenting vital signs. Markers of organ dysfunction may provide additional prognostic capability to these models. The objective of this study was to evaluate if urinary biomarkers are associated with poor outcomes, including death and the need for renal replacement therapy. Methods: We conducted a prospective, observational study in United States Military personnel with traumatic injury admitted to the intensive care unit at a combat support hospital in Afghanistan. Results: Eighty nine patients with urine samples drawn at admission to the intensive care unit were studied. Twelve patients subsequently died or needed renal replacement therapy. Median admission levels of urinary cystatin C (CyC), interleukin 18 (IL-18), L-type fatty acid binding protein (LFABP) and neutrophil gelatinase-associated lipocalin (NGAL) were significantly higher in patients that developed the combined outcome of death or need for renal replacement therapy. Median admission levels of kidney injury molecule-1 were not associated with the combined outcome. The area under the receiver operating characteristic curves for the combined outcome were 0.815, 0.682, 0.842 and 0.820 for CyC, IL-18, LFABP and NGAL, respectively. Multivariable regression adjusted for injury severity score, revealed CyC (OR 1.97, 95 % confidence interval 1.26-3.10, p = 0.003), LFABP (OR 1.92, 95 % confidence interval 1.24-2.99, p = 0.004) and NGAL (OR 1.80, 95 % confidence interval 1.21-2.66, p = 0.004) to be significantly associated with the composite outcome. Conclusions: Urinary biomarker levels at the time of admission are associated with death or need for renal replacement therapy. Larger multicenter studies will be required to determine how urinary biomarkers can best be used in future prediction models. C1 [Glass, Kristen R.; Morrow, Benjamin D.; Sosnov, Jonathan A.; Kwan, Hana K.; Henderson, Aaron T.; Saenz, Kristin K.] San Antonio Mil Med Ctr, Houston, TX 78234 USA. [Stewart, Ian J.; Glass, Kristen R.; Morrow, Benjamin D.; Sosnov, Jonathan A.; Chung, Kevin K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Howard, Jeffrey T.; Diaz, Christina; Chung, Kevin K.] US Army, Inst Surg Res, Houston, TX 78234 USA. [Siew, Edward D.; Wickersham, Nancy; Ikizler, T. Alp] Vanderbilt Univ, Med Ctr, Nashville, TN 37232 USA. [Latack, Wayne] Kessler Med Ctr, Keesler AFB, MS 39534 USA. [Heegard, Kelly D.] Eglin Hosp, Eglin AFB, FL 32542 USA. [Stewart, Ian J.] David Grant Med Ctr, Travis Air Force Base, CA 94535 USA. RP Stewart, IJ (reprint author), Uniformed Serv Univ Hlth Sci, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM ian.stewart@us.af.mil FU Air Force Medical Support Agency grant [EC-I-12-003]; Oak Ridge Institute of Science and Education FX The study was funded by an Air Force Medical Support Agency grant (EC-I-12-003) awarded to IJS and KKC. This project was also supported in part by a postdoctoral fellowship provided by the Oak Ridge Institute of Science and Education (JTH). The funding sources had no role in the design of the study, data collection, analysis or interpretation. The authors would like to thank the members of the United States Central Command Joint Combat Casualty Research Team who assisted with data collection. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Air Force, the Department of the Army or the Department of Defense. NR 26 TC 3 Z9 3 U1 3 U2 4 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1466-609X EI 1364-8535 J9 CRIT CARE JI Crit. Care PD JUN 16 PY 2015 VL 19 AR 252 DI 10.1186/s13054-015-0965-y PG 8 WC Critical Care Medicine SC General & Internal Medicine GA CL7KO UT WOS:000357151100001 PM 26077788 ER PT J AU Ahmed, A Gajavelli, S Spurlock, M Leung, LY Shear, D Tortella, F Bullock, R AF Ahmed, Aminul Gajavelli, Shyam Spurlock, Markus Leung, Lai Yee Shear, Deborah Tortella, Frank Bullock, Ross TI DIFFERENTIATION OF FDA-APPROVED HUMAN NEURAL STEM CELLS WITH FUNCTIONAL IMPROVEMENT AFTER A PENETRATING TBI SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 33rd Annual National Neurotrauma Symposium CY JUN 28-JUL 01, 2015 CL Santa Fe, NM DE Human Stem Cells; Penetrating Injury; Axonal Growth; Immunosuppression C1 [Ahmed, Aminul; Gajavelli, Shyam; Spurlock, Markus; Bullock, Ross] Univ Miami, Miami Project Cure Paralysis, Miami, FL USA. [Leung, Lai Yee; Shear, Deborah; Tortella, Frank] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2015 VL 32 IS 12 MA D4-02 BP A106 EP A107 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA CV0OB UT WOS:000363949000289 ER PT J AU Arun, P Wilder, D Rittase, W Mccuistion, M Oguntayo, S Wang, Y Gist, I Long, J AF Arun, Peethambaran Wilder, Donna Rittase, William Mccuistion, Meghan Oguntayo, Samuel Wang, Ying Gist, Irene Long, Joseph TI ALTERED TRYPTOPHAN METABOLISM IN BLAST-INDUCED TRAUMATIC BRAIN INJURY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 33rd Annual National Neurotrauma Symposium CY JUN 28-JUL 01, 2015 CL Santa Fe, NM DE Traumatic brain injury; Blast exposure; Tryptophan; Serotonin; Indoleamine 2,3-dioxygenase C1 [Arun, Peethambaran; Wilder, Donna; Rittase, William; Mccuistion, Meghan; Oguntayo, Samuel; Wang, Ying; Gist, Irene; Long, Joseph] Walter Reed Army Inst Res, Blast Induced Neurotrauma Ctr Mil Psychiat & Neur, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2015 VL 32 IS 12 MA C4-02 BP A83 EP A84 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA CV0OB UT WOS:000363949000225 ER PT J AU Boutte, A Wilfred, B Grant, S Abbatiello, B Cardiff, K Shear, D Tortella, F Leung, L AF Boutte, Angela Wilfred, Bernard Grant, Shonnette Abbatiello, Brittany Cardiff, Katherine Shear, Deborah Tortella, Frank Leung, LaiYee TI HYPOXEMIA AND HEMORRHAGIC SHOCK DELAY INFLAMMATION AND GFAP-DEGRADATION IN RAT PENETRATING BALLISTIC-LIKE BRAIN INJURY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 33rd Annual National Neurotrauma Symposium CY JUN 28-JUL 01, 2015 CL Santa Fe, NM DE Penetrating; Polytrauma; Hypoxemia; Hemorrhagic Shock; Cytokines C1 [Boutte, Angela; Wilfred, Bernard; Grant, Shonnette; Abbatiello, Brittany; Cardiff, Katherine; Shear, Deborah; Tortella, Frank; Leung, LaiYee] Walter Reed Army Inst Res, Brain Trauma Neuroprotect & Neurorestorat Branch, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2015 VL 32 IS 12 MA C7-28 BP A96 EP A96 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA CV0OB UT WOS:000363949000260 ER PT J AU Boutte, A Abbatiello, B Grant, S Hook, G Hook, V Tortella, F Shear, D AF Boutte, Angela Abbatiello, Brittany Grant, Shonnette Hook, Gregory Hook, Vivian Tortella, Frank Shear, Deborah TI BRAIN CATHEPSIN B IS ELEVATED IN BOTH MILD-CLOSED AND SEVERE-PENETRATING TRAUMATIC BRAIN INJURY MODELS SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 33rd Annual National Neurotrauma Symposium CY JUN 28-JUL 01, 2015 CL Santa Fe, NM DE Cathepsin B; Penetrating Ballistic-like Brain Injury; Projectile Concussive Impact C1 [Boutte, Angela; Abbatiello, Brittany; Grant, Shonnette; Tortella, Frank; Shear, Deborah] Walter Reed Army Inst Res, Brain Trauma Neuroprotect & Neurorestorat Branch, Silver Spring, MD USA. [Hook, Gregory] Amer Life Sci Pharmaceut Inc, Res & Dev, San Diego, CA USA. [Hook, Vivian] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, Dept Neurosci, La Jolla, CA 92093 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2015 VL 32 IS 12 MA B2-10 BP A49 EP A49 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA CV0OB UT WOS:000363949000131 ER PT J AU Boutte, A Mountney, A Abbatiello, B Grant, S Johnson, D Cartagena, C Tortella, F Shear, D AF Boutte, Angela Mountney, Andrea Abbatiello, Brittany Grant, Shonnette Johnson, David Cartagena, Casandra Tortella, Frank Shear, Deborah TI MULTIVARIATE BIOMARKER PROFILING, SENSORY MOTOR DEFICITS, CONSCIOUSNESS AFTER SINGLE AND REPEAT PROJECTILE CONCUSSIVE INJURY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 33rd Annual National Neurotrauma Symposium CY JUN 28-JUL 01, 2015 CL Santa Fe, NM DE Mild TBI; Concussion; CSF; GFAP; Tau; UCH-L1 C1 [Boutte, Angela; Mountney, Andrea; Abbatiello, Brittany; Grant, Shonnette; Johnson, David; Cartagena, Casandra; Tortella, Frank; Shear, Deborah] Walter Reed Army Inst Res, Brain Trauma Neuroprotect & Neurorestorat Branch, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2015 VL 32 IS 12 MA A5-18 BP A35 EP A36 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA CV0OB UT WOS:000363949000092 ER PT J AU Cartagena, C Jones, S Mountney, A Shear, D Braverman, S Wilson, C Jaiswal, S Tortella, F Selwyn, R AF Cartagena, Casandra Jones, Scott Mountney, Andrea Shear, Deborah Braverman, Stephanie Wilson, Colin Jaiswal, Shalini Tortella, Frank Selwyn, Reed TI ACUTE CHANGES IN FDG PET AFTER SINGLE AND REPEAT MTBI IN RATS CORRELATE WITH CLINICALLY RELEVANT SYMPTOMS OF CONCUSSION SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 33rd Annual National Neurotrauma Symposium CY JUN 28-JUL 01, 2015 CL Santa Fe, NM DE Concussion; mTBI; PET; FDG C1 [Cartagena, Casandra; Mountney, Andrea; Shear, Deborah; Braverman, Stephanie; Tortella, Frank] Walter Reed Army Inst Res, Brain Trauma Neuroprotect & Neurorestorat, Silver Spring, MD USA. [Jones, Scott; Wilson, Colin; Jaiswal, Shalini; Selwyn, Reed] Uniformed Serv Univ Hlth Sci, Translat Imaging Facil, Bethesda, MD 20814 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2015 VL 32 IS 12 MA B6-22 BP A66 EP A66 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA CV0OB UT WOS:000363949000176 ER PT J AU Caudle, K Mondello, S Gilsdorf, J Tortella, F Shear, D AF Caudle, Krista Mondello, Stefania Gilsdorf, Janice Tortella, Frank Shear, Deborah TI EVALUATION OF KOLLIDON VA64 IN THE WRAIR PBBI MODEL: STUDIES FROM THE OPERATION BRAIN TRAUMA THERAPY (OBTT) CONSORTIUM SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 33rd Annual National Neurotrauma Symposium CY JUN 28-JUL 01, 2015 CL Santa Fe, NM DE traumatic brain injury (TBI); Kollidon VA64; Operation Brain Trauma Therapy (OBTT); neurobehavior motor cognitive C1 [Caudle, Krista; Gilsdorf, Janice; Tortella, Frank; Shear, Deborah] Walter Reed Army Inst Res, Brain Trauma Neuroprotect & Neurorestorat, Silver Spring, MD USA. [Mondello, Stefania] Univ Messina, Dept Neurosci, Messina, Italy. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2015 VL 32 IS 12 MA D8-23 BP A121 EP A121 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA CV0OB UT WOS:000363949000330 ER PT J AU Demar, J Hill, M Wilder, D Rosenberger, J Mccuistion, M Long, J AF Demar, James Hill, Miya Wilder, Donna Rosenberger, John Mccuistion, Meghan Long, Joseph TI EVALUATION OF POLYUNSATURATED FATTY ACID DERIVED MEDIATORS OF INFLAMMATION TO AMELIORATE PRIMARY BLAST WAVE INJURIES IN RATS SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 33rd Annual National Neurotrauma Symposium CY JUN 28-JUL 01, 2015 CL Santa Fe, NM DE Blast wave; Rat; Eye; Retina; Brain; Polyunsaturated Fatty Acids C1 [Demar, James; Hill, Miya; Wilder, Donna; Rosenberger, John; Mccuistion, Meghan; Long, Joseph] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2015 VL 32 IS 12 MA C7-25 BP A95 EP A95 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA CV0OB UT WOS:000363949000257 ER PT J AU Deng-Bryant, Y Mondello, S Leung, LY Gilsdorf, J Pedersen, R Sun, J Flerlage, W Tortella, F Shear, D AF Deng-Bryant, Ying Mondello, Stefania Leung, Lai Yee Gilsdorf, Janice Pedersen, Rebecca Sun, Justin Flerlage, William Tortella, Frank Shear, Deborah TI EVALUATION OF GLIBENCLAMIDE IN THE WRAIR PBBI MODEL: STUDIES FROM THE OPERATION BRAIN TRAUMA THERAPY (OBTT) CONSORTIUM SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 33rd Annual National Neurotrauma Symposium CY JUN 28-JUL 01, 2015 CL Santa Fe, NM DE PBBI; Behavior C1 [Deng-Bryant, Ying; Mondello, Stefania; Leung, Lai Yee; Gilsdorf, Janice; Pedersen, Rebecca; Sun, Justin; Flerlage, William; Tortella, Frank; Shear, Deborah] Walter Reed Army Inst Res, Ctr Mil Psychiatry & Neurosci, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2015 VL 32 IS 12 MA D8-26 BP A122 EP A122 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA CV0OB UT WOS:000363949000333 ER PT J AU Deng-Bryant, Y Leung, LY Yang, WH Tortella, F Shear, D AF Deng-Bryant, Ying Leung, Lai Yee Yang, Weihong Tortella, Frank Shear, Deborah TI DISCOVERING PROGNOSTICATORS FOR REPEATED CONCUSSIONS: A GLOBAL METABOLOMIC STUDY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 33rd Annual National Neurotrauma Symposium CY JUN 28-JUL 01, 2015 CL Santa Fe, NM DE Metabolomics; Concussion C1 [Deng-Bryant, Ying; Leung, Lai Yee; Yang, Weihong; Tortella, Frank; Shear, Deborah] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2015 VL 32 IS 12 MA A5-20 BP A36 EP A36 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA CV0OB UT WOS:000363949000094 ER PT J AU Deng-Bryant, Y Madathil, SK Leung, LY Liao, ZL Tortella, F Shear, D AF Deng-Bryant, Ying Madathil, Sindhu Kizhakke Leung, Lai Yee Liao, Zhilin Tortella, Frank Shear, Deborah TI CHARACTERIZATION OF ENDOGENOUS BRAIN-DERIVED NEUROTROPHIC FACTOR EXPRESSION IN RESPONSE TO PENETRATING BALLISTIC-LIKE INJURY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 33rd Annual National Neurotrauma Symposium CY JUN 28-JUL 01, 2015 CL Santa Fe, NM DE BDNF; Synaptophysin; GAP-43; PBBI C1 [Deng-Bryant, Ying; Madathil, Sindhu Kizhakke; Leung, Lai Yee; Liao, Zhilin; Tortella, Frank; Shear, Deborah] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2015 VL 32 IS 12 MA S10-05 BP A11 EP A11 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA CV0OB UT WOS:000363949000026 ER PT J AU Gajavelli, S Spurlock, M Ahmed, A Rivera, K Leung, LY Shear, D Yokobori, S Tortella, F Hazel, T Bullock, R AF Gajavelli, Shyam Spurlock, Markus Ahmed, Aminul Rivera, Karla Leung, Lai Yee Shear, Deborah Yokobori, Shoji Tortella, Frank Hazel, Tom Bullock, Ross TI SURVIVAL AND BIODISTRIBUTION OF HUMAN FETAL NEURAL STEM CELL TRANSPLANTS IN PENETRATING BALLISTIC BRAIN INJURY (PBBI) SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 33rd Annual National Neurotrauma Symposium CY JUN 28-JUL 01, 2015 CL Santa Fe, NM DE Penetrating traumatic brain injury; Neural stem cell transplants; FDA; Neurogenesis; Light sheet microscopy C1 [Gajavelli, Shyam; Spurlock, Markus; Ahmed, Aminul; Rivera, Karla; Bullock, Ross] Univ Miami, Miami Project Cure Paralysis, Miami, FL USA. [Yokobori, Shoji] Nippon Med Sch, Dept Emergency & Crit Care Med, Tokyo 113, Japan. [Leung, Lai Yee; Shear, Deborah; Tortella, Frank] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect & Neurorestorat, Silver Spring, MD USA. [Hazel, Tom] Neuralstem Inc, Germantown, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2015 VL 32 IS 12 MA D3-01 BP A105 EP A106 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA CV0OB UT WOS:000363949000286 ER PT J AU Johnson, D Boutte, A Schmid, K Dave, J Tortella, F Cartagena, C AF Johnson, David Boutte, Angela Schmid, Kara Dave, Jitendra Tortella, Frank Cartagena, Casandra TI ACUTE AND SUBACUTE MICRORNA MODULATION FOLLOWING PBBI SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 33rd Annual National Neurotrauma Symposium CY JUN 28-JUL 01, 2015 CL Santa Fe, NM DE microRNA; TBI; Array C1 [Johnson, David; Boutte, Angela; Schmid, Kara; Dave, Jitendra; Tortella, Frank; Cartagena, Casandra] Walter Reed Army Inst Res, Psychiat & Neurosci, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2015 VL 32 IS 12 MA C7-26 BP A95 EP A95 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA CV0OB UT WOS:000363949000258 ER PT J AU Johnson, D Boutte, A Schmid, K Shear, D Dave, J Tortella, F Cartagena, C AF Johnson, David Boutte, Angela Schmid, Kara Shear, Deborah Dave, Jitendra Tortella, Frank Cartagena, Casandra TI INVESTIGATION OF PUTATIVE ACUTE SERUM DIAGNOSTIC BIOMARKERS IN A PROJECTILE CONCUSSIVE IMPACT INJURY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 33rd Annual National Neurotrauma Symposium CY JUN 28-JUL 01, 2015 CL Santa Fe, NM DE microRNA; mild TBI; array C1 [Johnson, David; Boutte, Angela; Schmid, Kara; Shear, Deborah; Dave, Jitendra; Tortella, Frank; Cartagena, Casandra] Walter Reed Army Inst Res, Psychiat & Neurosci, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2015 VL 32 IS 12 MA A5-19 BP A36 EP A36 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA CV0OB UT WOS:000363949000093 ER PT J AU Leung, LY Deng-Bryant, Y Wilfred, B Cardiff, K Yang, XF Vandermerwe, C Shear, D Tortella, F AF Leung, Lai Yee Deng-Bryant, Ying Wilfred, Bernard Cardiff, Katherine Yang, Xiaofang Vandermerwe, Christopher Shear, Deborah Tortella, Frank TI SELECTIVE BRAIN COOLING REDUCES MOTOR DEFICITS INDUCED BY COMBINED TRAUMATIC BRAIN INJURY, HYPOXEMIA AND HEMORRHAGIC SHOCK SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 33rd Annual National Neurotrauma Symposium CY JUN 28-JUL 01, 2015 CL Santa Fe, NM DE Polytrauma; therapeutic hypothermia; selective brain cooling; hypoxemia; hemorrhagic shock C1 [Leung, Lai Yee; Deng-Bryant, Ying; Wilfred, Bernard; Cardiff, Katherine; Yang, Xiaofang; Vandermerwe, Christopher; Shear, Deborah; Tortella, Frank] Walter Reed Army Inst Res, Brain Trauma Neuroprotect & Neurorestorat Branch, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2015 VL 32 IS 12 MA D8-25 BP A122 EP A122 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA CV0OB UT WOS:000363949000332 ER PT J AU Lu, XCM Cao, Y Liao, ZL Tortella, F Shear, D AF Lu, Xi-Chun May Cao, Ying Liao, Zhinlin Tortella, Frank Shear, Deborah TI TIME-COURSE PROFILE OF EEG ABNORMALITY DETECTED BY QEEG POWER SPECTRAL ANALYSIS FOLLOWING A SINGLE CONCUSSIVE BRAIN INJURY IN RATS SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 33rd Annual National Neurotrauma Symposium CY JUN 28-JUL 01, 2015 CL Santa Fe, NM DE EEG Power Spectrum Analysis; Projectile Concussive Impact Brain Injury; Rats C1 [Lu, Xi-Chun May; Cao, Ying; Liao, Zhinlin; Tortella, Frank; Shear, Deborah] Walter Reed Army Inst Res, Brain Trauma Neuroprotect & Neurorestorat Psychia, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2015 VL 32 IS 12 MA C6-04 BP A86 EP A86 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA CV0OB UT WOS:000363949000232 ER PT J AU Lu, XCM Tallarida, R Cao, Y Liao, ZL Shear, D Tortella, F AF Lu, Xi-Chun May Tallarida, Ronald Cao, Ying Liao, Zhinlin Shear, Deborah Tortella, Frank TI EFFECTS OF LEVETIRACETAM AND GABAPENTIN COMBINATION THERAPY ON POST-TRAUMATIC NON-CONVULSIVE SEIZURES (NCS) INDUCED BY A PENETRATIN SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 33rd Annual National Neurotrauma Symposium CY JUN 28-JUL 01, 2015 CL Santa Fe, NM DE Combination Therapy; Penetrating brain Injury; Levetiracetam; Gabapentin; Isobolographic analysis C1 [Lu, Xi-Chun May; Cao, Ying; Liao, Zhinlin; Shear, Deborah; Tortella, Frank] Walter Reed Army Inst Res, Brain Trauma Neuroprotect & Neurorestorat Psychia, Silver Spring, MD USA. [Tallarida, Ronald] Temple Univ, Dept Pharmacol, Philadelphia, PA 19122 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2015 VL 32 IS 12 MA B4-04 BP A56 EP A56 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA CV0OB UT WOS:000363949000150 ER PT J AU Lu, XCM Tallarida, R Cao, Y Liao, ZL Shear, D Tortella, F AF Lu, Xi-Chun May Tallarida, Ronald Cao, Ying Liao, Zhilin Shear, Deborah Tortella, Frank TI SYNERGISTIC EFFECTS OF PHENYTOIN AND ETHOSUXIMIDE AGAINST POST-TRAUMATIC NONCONVULSIVE SEIZURES SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 33rd Annual National Neurotrauma Symposium CY JUN 28-JUL 01, 2015 CL Santa Fe, NM DE Combination Therapy; Penetrating Brain Injury; Phenytoin; Ethoxusimide; Isobolographic Analysis C1 [Lu, Xi-Chun May; Cao, Ying; Liao, Zhilin; Shear, Deborah; Tortella, Frank] Walter Reed Army Inst Res, Brain Trauma Neuroprotect & Neurorestorat Psychia, Silver Spring, MD USA. [Tallarida, Ronald] Temple Univ, Dept Pharmacol, Philadelphia, PA 19122 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2015 VL 32 IS 12 MA B4-05 BP A57 EP A57 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA CV0OB UT WOS:000363949000151 ER PT J AU Madathil, SK Leung, LY Cardiff, K Yang, XF Tortella, F Shear, D Deng-Bryant, Y AF Madathil, Sindhu Kizhakke Leung, Lai Yee Cardiff, Katherine Yang, Xiaofang Tortella, Frank Shear, Deborah Deng-Bryant, Ying TI TEMPORAL AND REGIONAL CHANGES IN MICROGLIAL PROLIFERATION FOLLOWING PENETRATING BALLISTIC-LIKE BRAIN INJURY IN RATS SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 33rd Annual National Neurotrauma Symposium CY JUN 28-JUL 01, 2015 CL Santa Fe, NM DE Microglia; Proliferation; PBBI C1 [Madathil, Sindhu Kizhakke; Leung, Lai Yee; Cardiff, Katherine; Yang, Xiaofang; Tortella, Frank; Shear, Deborah; Deng-Bryant, Ying] Walter Reed Army Inst Res, BTNN, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2015 VL 32 IS 12 MA C7-29 BP A96 EP A97 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA CV0OB UT WOS:000363949000261 ER PT J AU Mountney, A Shear, D Rho, C Flerlage, W Dougherty, J Schmid, K Balkin, T Tortella, F AF Mountney, Andrea Shear, Deborah Rho, Chanyang Flerlage, William Dougherty, Jacqueline Schmid, Kara Balkin, Thomas Tortella, Frank TI THE EFFECTS OF SLEEP-ALTERING DRUGS ON SLEEP ARCHITECTURE RELATIVE TO TRAUMATIC BRAIN INJURY IN RATS SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 33rd Annual National Neurotrauma Symposium CY JUN 28-JUL 01, 2015 CL Santa Fe, NM DE sleep; TBI; caffeine; ambien C1 [Mountney, Andrea; Shear, Deborah; Rho, Chanyang; Flerlage, William; Dougherty, Jacqueline; Schmid, Kara; Tortella, Frank] Walter Reed Army Inst Res, BTNN, Silver Spring, MD USA. [Balkin, Thomas] Walter Reed Army Inst Res, Behav Biol, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 3 U2 3 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2015 VL 32 IS 12 MA D8-24 BP A121 EP A122 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA CV0OB UT WOS:000363949000331 ER PT J AU Shear, D AF Shear, Deborah TI A UNIQUE TOOL FOR CROSS MODEL COMPARISON IN PRECLINICAL TRAUMATIC BRAIN INJURY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 33rd Annual National Neurotrauma Symposium CY JUN 28-JUL 01, 2015 CL Santa Fe, NM DE TBI; OBTT; Neuroprotection; Biomarkers C1 [Shear, Deborah] Walter Reed Army Inst Res, Brain Trauma Neuroprotect & Neurorestorat Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2015 VL 32 IS 12 MA S08-02 BP A142 EP A142 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA CV0OB UT WOS:000363949000399 ER PT J AU Smith, DH Hicks, RR Johnson, VE Cummings, DM Bergstrom, DA Noble, LJ Hovda, D Whalen, M Ahlers, ST LaPlaca, M Tortella, FC Duhaime, AC Dixon, CE AF Smith, Douglas H. Hicks, Ramona R. Johnson, Victoria E. Cummings, Diana M. Bergstrom, Debra A. Noble, Linda J. Hovda, David Whalen, Michael Ahlers, Stephen T. LaPlaca, Michelle Tortella, Frank C. Duhaime, Ann-Christine Dixon, C. Edward TI PRECLINICAL TRAUMATIC BRAIN INJURY COMMON DATA ELEMENTS: TOWARDS A COMMON LANGUAGE ACROSS LABORATORIES SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 33rd Annual National Neurotrauma Symposium CY JUN 28-JUL 01, 2015 CL Santa Fe, NM DE Modeling C1 [Smith, Douglas H.; Johnson, Victoria E.] Univ Penn, Dept Neurosurg, Philadelphia, PA 19104 USA. [Hicks, Ramona R.; Cummings, Diana M.; Bergstrom, Debra A.] NINDS, NIH, Bethesda, MD 20892 USA. [Hicks, Ramona R.] One Mind, Leadership Team, Seattle, WA USA. [Noble, Linda J.] Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA USA. [Hovda, David] Univ Calif Los Angeles, Neurosurg, Los Angeles, CA USA. [Whalen, Michael] Massachusetts Gen Hosp, Neurosci Ctr, Charlestown, MA USA. [Ahlers, Stephen T.] Naval Med Res Ctr, Operat & Undersea Med, Silver Spring, MD USA. [LaPlaca, Michelle] Georgia Tech, Atlanta, GA USA. [LaPlaca, Michelle] Emory Univ, Biomed Engn, Atlanta, GA 30322 USA. [Tortella, Frank C.] Walter Reed Army Inst Res, Brain Trauma Neuroprotect & Neurorestorat, Silver Spring, MD USA. [Duhaime, Ann-Christine] Harvard Univ, Sch Med, Dept Neurosurg, Boston, MA USA. [Dixon, C. Edward] Univ Pittsburgh, Dept Neurol Surg, Pittsburg, KS USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2015 VL 32 IS 12 MA PL07-03 BP A135 EP A135 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA CV0OB UT WOS:000363949000375 ER PT J AU Temkin, N Bell, K Fann, J Brockway, JA Cole, W AF Temkin, Nancy Bell, Kathleen Fann, Jesse Brockway, Jo Ann Cole, Wesley CA CONTACT Study Grp TI TELEPHONE PROBLEM SOLVING TREATMENT FOR ACTIVE DUTY SERVICE MEMBERS WITH MILD TRAUMATIC BRAIN INJURY: A RANDOMIZED CONTROLLED TRIAL SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 33rd Annual National Neurotrauma Symposium CY JUN 28-JUL 01, 2015 CL Santa Fe, NM DE Military; Mild traumatic brain injury; Randomized controlled trial; Telehealth; Problem-solving treatment C1 [Temkin, Nancy] Univ Washington, Neurol Surg & Biostat, Seattle, WA 98195 USA. [Bell, Kathleen; Brockway, Jo Ann] UW, Rehabil Med, Seattle, WA USA. [Fann, Jesse] UW, Psychiat & Behav Sci, Seattle, WA USA. [Cole, Wesley] Womack Army Med Ctr, Def & Vet Brain Injury Ctr, Brain Injury Med, Ft Bragg, NC USA. [CONTACT Study Grp] INTRuST, San Diego, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2015 VL 32 IS 12 MA D6-08 BP A112 EP A112 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA CV0OB UT WOS:000363949000304 ER PT J AU Wang, Y Wei, YL Oguntayo, S Wilder, D Arun, P Gist, I Long, J AF Wang, Ying Wei, Yanling Oguntayo, Samuel Wilder, Donna Arun, Peethambaran Gist, Irene Long, Joseph TI CCL2 LEVELS IN CSF AND ITS CORRELATION WITH BLAST-INDUCED NEUROTRAUMA IN RATS SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 33rd Annual National Neurotrauma Symposium CY JUN 28-JUL 01, 2015 CL Santa Fe, NM DE Blast; Neurotrauma; Chemokine; CSF C1 [Wang, Ying; Wei, Yanling; Oguntayo, Samuel; Wilder, Donna; Arun, Peethambaran; Gist, Irene; Long, Joseph] Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2015 VL 32 IS 12 MA C7-27 BP A96 EP A96 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA CV0OB UT WOS:000363949000259 ER PT J AU Lesho, EP AF Lesho, Emil P. TI Fighting Ebola and Advancing Knowledge on the Front Lines in a Capital City SO CLINICAL INFECTIOUS DISEASES LA English DT Editorial Material DE Ebola; relief mission; humanitarian response; predictors ID HEMORRHAGIC-FEVER; VIRUS DISEASE; EXPRESSION; OUTBREAK; CONGO; EPIDEMIC; KIKWIT; CELLS C1 Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Lesho, EP (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM carolinelesho@yahoo.com NR 29 TC 1 Z9 1 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD JUN 15 PY 2015 VL 60 IS 12 BP 1825 EP 1827 DI 10.1093/cid/civ204 PG 3 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA CN0BC UT WOS:000358075800016 PM 25770170 ER PT J AU Drost, RJ Sadler, BM Chen, G AF Drost, Robert J. Sadler, Brian M. Chen, Gang TI Dead time effects in non-line-of-sight ultraviolet communications SO OPTICS EXPRESS LA English DT Article ID PHOTOCOUNTING DISTRIBUTIONS; COUNTING STATISTICS; LASER-RADIATION; PATH LOSS; PERFORMANCE; RANGE; CHANNELS AB By exploiting unique properties of the atmospheric propagation of radiation in the deep-ultraviolet band (200-300 nm), ultraviolet communications (UVC) offers the novel possibility of establishing non-line-of-sight (NLOS) optical links. UVC systems often employ photon-counting receivers, which may exhibit nonideal behavior owing to dead time, a period of time after the detection of a photon during which such a receiver is unable to detect subsequently impinging photons. In this paper, we extend a NLOS UVC channel model to account for dead time and then use this extended model to study the effects of dead time in representative system scenarios. Experimentally collected channel-sounding data is then used for model validation and real-world illustration of these effects. Finally, we investigate the effect of dead time on communication performance. The results demonstrate that dead time can have a significant impact in practical communication scenarios and suggest the usefulness of the proposed modeling framework in developing receiver designs that compensate for dead time effects. (C) 2015 Optical Society of America C1 [Drost, Robert J.; Sadler, Brian M.] Army Res Lab, Adelphi, MD 20783 USA. [Chen, Gang] Univ Calif Riverside, Dept Elect Engn, Riverside, CA 92521 USA. RP Drost, RJ (reprint author), Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM robert.j.drost6.civ@mail.mil NR 33 TC 2 Z9 3 U1 1 U2 13 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD JUN 15 PY 2015 VL 23 IS 12 BP 15748 EP 15761 DI 10.1364/OE.23.015748 PG 14 WC Optics SC Optics GA CL4DJ UT WOS:000356902500061 PM 26193553 ER PT J AU Steinmacher, M Harmon, GJC AF Steinmacher, Michael Harmon, G. J. Corey TI What's in the Box? SO LIBRARY JOURNAL LA English DT Editorial Material C1 [Steinmacher, Michael] Barr Mem Lib, Ft Knox, KY 40121 USA. [Harmon, G. J. Corey] US Mil Acad, West Point, NY 10996 USA. RP Steinmacher, M (reprint author), Barr Mem Lib, Ft Knox, KY 40121 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD JUN 15 PY 2015 VL 140 IS 11 BP 44 EP 44 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA CL0OI UT WOS:000356641600021 ER PT J AU Burgess, E AF Burgess, Edwin TI Base Nation: How US Military Bases Abroad Harm America and the World SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin] US Army Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. RP Burgess, E (reprint author), US Army Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD JUN 15 PY 2015 VL 140 IS 11 BP 100 EP 100 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA CL0OI UT WOS:000356641600193 ER PT J AU Redding, B Pan, YL AF Redding, Brandon Pan, Yong-Le TI Optical trap for both transparent and absorbing particles in air using a single shaped laser beam SO OPTICS LETTERS LA English DT Article ID RADIATION PRESSURE; MANIPULATION; LEVITATION; AEROSOLS AB Optical trapping of airborne particles is emerging as an essential tool in applications ranging from online characterization of living cells and aerosols to particle transport and delivery. However, existing optical trapping techniques using a single laser beam can trap only transparent particles (via the radiative pressure force) or absorbing particles (via the photophoretic force), but not particles of either type-limiting the utility of trapping-enabled aerosol characterization techniques. Here, we present the first optical trapping technique capable of trapping both transparent and absorbing particles with arbitrary morphology using a single shaped laser beam. Such a general-purpose optical trapping mechanism could enable new applications such as trapping-enabled aerosol characterization with high specificity. (C) 2015 Optical Society of America C1 [Redding, Brandon; Pan, Yong-Le] US Army Res Lab, Adelphi, MD 20783 USA. RP Pan, YL (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM yongle.pan.civ@mail.mil FU Defense Threat Reduction Agency (DTRA) [HDTRA1310184, HDTRA1514122]; US Army Research Laboratory [W911NF-12-2-0019] FX Defense Threat Reduction Agency (DTRA) (HDTRA1310184, HDTRA1514122); US Army Research Laboratory (W911NF-12-2-0019). NR 31 TC 8 Z9 9 U1 3 U2 16 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0146-9592 EI 1539-4794 J9 OPT LETT JI Opt. Lett. PD JUN 15 PY 2015 VL 40 IS 12 BP 2798 EP 2801 DI 10.1364/OL.40.002798 PG 4 WC Optics SC Optics GA CK5AK UT WOS:000356234300032 PM 26076265 ER PT J AU Lee, M Leiter, K Eisner, C Crone, J Knap, J AF Lee, M. Leiter, K. Eisner, C. Crone, J. Knap, J. TI Extended Huckel and Slater's rule initial guess for real space grid-based density functional theory SO COMPUTATIONAL AND THEORETICAL CHEMISTRY LA English DT Article DE Finite element method; Molecular orbital; Slater orbital; Self-consistent field; Iterative eigensolver; Poisson equation ID EIGENVALUE PROBLEMS; BASIS-SETS; ITERATION; CONSTANTS; EQUATIONS; SYSTEMS AB The Extended Huckel method is commonly used as an initial guess for Gaussian basis set quantum chemistry calculations. In this work, we combine the Extended Huckel method and Slater's rules to form an initial guess of the electron density and molecular orbitals for all-electron real-space finite element Kohn-Sham density functional theory (FE-KSDFT). With this approach, the first SCF iteration is close in energy to the converged solution, and a factor of two speedup is obtained vs. a naive initial electron density composed of a superposition of atomic densities. In addition, because the guessed molecular orbitals are already partially self-consistent with the guess density, we can now employ less robust, but fast, block eigensolvers such as Chebyshev-filtered subspace iteration even in the first SCF iteration to achieve 2-10x further gains vs. a conventional Jacobi-Davidson eigensolver. Published by Elsevier B.V. C1 [Lee, M.; Leiter, K.; Eisner, C.; Crone, J.; Knap, J.] US Army, Res Lab, Simulat Sci Branch, Aberdeen Proving Ground, MD 21005 USA. [Eisner, C.] Secure Miss Solut, Reston, VA USA. RP Lee, M (reprint author), US Army, Res Lab, Simulat Sci Branch, Aberdeen Proving Ground, MD 21005 USA. EM michael.s.lee131.civ@mail.mil FU ARL Computational Methods for Multi-Scale Modeling program FX We would like to thank Prof. V. Gavini, Dr. P. Motamarri and Dr. M. Iyer for helpful conversations and the mesh generation script. Computational time was provided by the U.S. Army Research Laboratory DoD Supercomputing Resource Center and the Navy DoD Supercomputing Resource Center. Funding was provided by the ARL Computational Methods for Multi-Scale Modeling program. NR 23 TC 2 Z9 2 U1 1 U2 12 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 2210-271X EI 1872-7999 J9 COMPUT THEOR CHEM JI Comput. Theor. Chem. PD JUN 15 PY 2015 VL 1062 BP 24 EP 29 DI 10.1016/j.comptc.2015.03.011 PG 6 WC Chemistry, Physical SC Chemistry GA CI8TF UT WOS:000355043900003 ER PT J AU Rowan, MP Cancio, LC Elster, EA Burmeister, DM Rose, LF Natesan, S Chan, RK Christy, RJ Chung, KK AF Rowan, Matthew P. Cancio, Leopoldo C. Elster, Eric A. Burmeister, David M. Rose, Lloyd F. Natesan, Shanmugasundaram Chan, Rodney K. Christy, Robert J. Chung, Kevin K. TI Burn wound healing and treatment: review and advancements SO CRITICAL CARE LA English DT Review ID CULTURED EPITHELIAL AUTOGRAFT; ENGINEERED SKIN SUBSTITUTES; HYPERBARIC-OXYGEN THERAPY; HUMAN DERMAL FIBROBLASTS; MUSCLE PROTEIN-SYNTHESIS; COMBAT-RELATED INJURIES; MESENCHYMAL STEM-CELLS; GRAFT DONOR-SITE; THERMAL BURNS; EARLY EXCISION AB Burns are a prevalent and burdensome critical care problem. The priorities of specialized facilities focus on stabilizing the patient, preventing infection, and optimizing functional recovery. Research on burns has generated sustained interest over the past few decades, and several important advancements have resulted in more effective patient stabilization and decreased mortality, especially among young patients and those with burns of intermediate extent. However, for the intensivist, challenges often exist that complicate patient support and stabilization. Furthermore, burn wounds are complex and can present unique difficulties that require late intervention or life-long rehabilitation. In addition to improvements in patient stabilization and care, research in burn wound care has yielded advancements that will continue to improve functional recovery. This article reviews recent advancements in the care of burn patients with a focus on the pathophysiology and treatment of burn wounds. C1 [Rowan, Matthew P.; Cancio, Leopoldo C.; Burmeister, David M.; Rose, Lloyd F.; Natesan, Shanmugasundaram; Chan, Rodney K.; Christy, Robert J.; Chung, Kevin K.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Elster, Eric A.; Chung, Kevin K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Chan, Rodney K.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Rowan, MP (reprint author), US Army, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM p.rowan.vol@mail.mil OI Natesan, Shanmugasundaram/0000-0003-4213-3111 FU US Department of Energy; US Army Medical Research and Materiel Command FX The authors would like to thank the staff of the Clinical Trials task area at the US Army Institute of Surgical Research for administrative support. The authors would also like to thank Dr Harold Klemcke for critical review of this manuscript. This work was supported in part by an appointment (MPR) to the Postgraduate Research Participation Program and an appointment (LCC) to the Knowledge Preservation Program at the US Army Institute of Surgical Research administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the US Department of Energy and US Army Medical Research and Materiel Command. NR 213 TC 6 Z9 6 U1 18 U2 63 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1466-609X EI 1364-8535 J9 CRIT CARE JI Crit. Care PD JUN 12 PY 2015 VL 19 DI 10.1186/s13054-015-0961-2 PG 12 WC Critical Care Medicine SC General & Internal Medicine GA CK4ZV UT WOS:000356232800001 ER PT J AU Ervin, MH AF Ervin, Matthew H. TI Etching holes in graphene supercapacitor electrodes for faster performance SO NANOTECHNOLOGY LA English DT Article DE graphene; supercapacitor; reactive ion etching; electrodes; electrochemical sensors ID ELECTROCHEMICAL CAPACITORS; FILM; DEPOSITION; IMPEDANCE; OXIDE AB Graphene is being widely investigated as a material to replace activated carbon in supercapacitor (electrochemical capacitor) electrodes. Supercapacitors have much higher energy density, but are typically slow devices (similar to 0.1 Hz) compared to other types of capacitors. Here, top-down semiconductor processing has been applied to graphene-based electrodes in order to fabricate ordered arrays of holes through the graphene electrodes. This is demonstrated to increase the speed of the electrodes by reducing the ionic impedance through the electrode thickness. This approach may also be applicable to speeding up other types of devices, such as batteries and sensors, that use porous electrodes. C1 US Army, Res Lab, Adelphi, MD 20783 USA. RP Ervin, MH (reprint author), US Army, Res Lab, Adelphi, MD 20783 USA. EM Matthew.H.Ervin.civ@mail.mil NR 23 TC 1 Z9 1 U1 7 U2 63 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0957-4484 EI 1361-6528 J9 NANOTECHNOLOGY JI Nanotechnology PD JUN 12 PY 2015 VL 26 IS 23 AR 234003 DI 10.1088/0957-4484/26/23/234003 PG 9 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Science & Technology - Other Topics; Materials Science; Physics GA CI6UT UT WOS:000354899200003 PM 25994042 ER PT J AU Chaccour, CJ Rabinovich, NR Slater, H Canavati, SE Bousema, T Lacerda, M ter Kuile, F Drakeley, C Bassat, Q Foy, BD Kobylinski, K AF Chaccour, Carlos J. Rabinovich, N. Regina Slater, Hannah Canavati, Sara E. Bousema, Teun Lacerda, Marcus ter Kuile, Feiko Drakeley, Chris Bassat, Quique Foy, Brian D. Kobylinski, Kevin TI Establishment of the Ivermectin Research for Malaria Elimination Network: updating the research agenda SO MALARIA JOURNAL LA English DT Article DE Ivermectin; Endectocides; Vector control; Residual malaria transmission; Malaria elimination; Research agenda ID PLASMODIUM-FALCIPARUM; PARASITE TRANSMISSION; MASS TREATMENT; EFFICACY; VECTORS; SAFETY; ONCHOCERCIASIS; ERADICATION; PIPERAQUINE; CHALLENGES AB The potential use of ivermectin as an additional vector control tool is receiving increased attention from the malaria elimination community, driven by the increased importance of outdoor/residual malaria transmission and the threat of insecticide resistance where vector tools have been scaled-up. This report summarizes the emerging evidence presented at a side meeting on "Ivermectin for malaria elimination: current status and future directions" at the annual meeting of the American Society of Tropical Medicine and Hygiene in New Orleans on November 4, 2014. One outcome was the creation of the "Ivermectin Research for Malaria Elimination Network" whose main goal is to establish a common research agenda to generate the evidence base on whether ivermectin-based strategies should be added to the emerging arsenal to interrupt malaria transmission. C1 [Chaccour, Carlos J.] Univ Navarra Clin, Dept Internal Med, Pamplona, Spain. [Chaccour, Carlos J.; Rabinovich, N. Regina; Bassat, Quique] Univ Barcelona, Hosp Clin, ISGlobal, Barcelona Ctr Int Hlth Res CRESIB, Barcelona, Spain. [Chaccour, Carlos J.] Univ Navarra, Inst Salud Trop, E-31080 Pamplona, Spain. [Rabinovich, N. Regina] Harvard TH Chan Sch Publ Hlth, Boston, MA USA. [Slater, Hannah] Univ London Imperial Coll Sci Technol & Med, Dept Infect Dis Epidemiol, MRC Ctr Outbreak Anal & Modelling, London, England. [Canavati, Sara E.] Mahidol Univ, Fac Trop Med, Dept Clin Trop Med, Bangkok 10700, Thailand. [Bousema, Teun] Radboud Univ Nijmegen, Med Ctr, NL-6525 ED Nijmegen, Netherlands. [Lacerda, Marcus] Fiocruz MS, Fundacao Med Trop Dr Heitor Vieira Dourado, Manaus, Amazonas, Brazil. [ter Kuile, Feiko] Univ Liverpool, Liverpool Sch Trop Med, Liverpool L3 5QA, Merseyside, England. [Drakeley, Chris] London Sch Hyg & Trop Med, Malaria Ctr, London WC1, England. [Bassat, Quique] Ctr Invest Saude Manh, Maputo, Mozambique. [Foy, Brian D.] Colorado State Univ, Dept Microbiol, Arthropod Borne & Infect Dis Lab, Immunol & Pathol, Ft Collins, CO 80523 USA. [Kobylinski, Kevin] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Kobylinski, Kevin] Walter Reed Inst Res, Entomol Branch, Silver Spring, MD USA. RP Chaccour, CJ (reprint author), Univ Navarra Clin, Dept Internal Med, Pamplona, Spain. EM carlos.chaccour@isglobal.org RI Bousema, Teun/N-3574-2014; Bassat, Quique/P-2341-2016; Foy, Brian/E-6230-2017; OI Bassat, Quique/0000-0003-0875-7596; Foy, Brian/0000-0002-9117-203X; Slater, Hannah/0000-0003-4291-7899; ter Kuile, Feiko/0000-0003-3663-5617 FU Instituto de Salud Tropical, Universidad de Navarra (ISTUN); Barcelona Institute for Global health (ISGlobal) FX The side meeting "Ivermectin for malaria elimination: current status and future directions" was funded by the Instituto de Salud Tropical, Universidad de Navarra (ISTUN) and the Barcelona Institute for Global health (ISGlobal). The opinions or assertions contained herein are the private views of the author, and are not to be construed as official, or as reflecting true views of the Department of the Army or the Department of Defense. NR 37 TC 10 Z9 10 U1 2 U2 6 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD JUN 11 PY 2015 VL 14 AR 243 DI 10.1186/s12936-015-0691-6 PG 8 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA CK8KZ UT WOS:000356488200001 PM 26068560 ER PT J AU Kiris, E Nuss, JE Stanford, SM Wanner, LM Cazares, L Maestre, MF Du, HT Gomba, GY Burnett, JC Gussio, R Bottini, N Panchal, RG Kane, CD Tessarollo, L Bavari, S AF Kiris, Erkan Nuss, Jonathan E. Stanford, Stephanie M. Wanner, Laura M. Cazares, Lisa Maestre, Michael F. Du, Hao T. Gomba, Glenn Y. Burnett, James C. Gussio, Rick Bottini, Nunzio Panchal, Rekha G. Kane, Christopher D. Tessarollo, Lino Bavari, Sina TI Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays SO PLOS ONE LA English DT Article ID PROTEIN-KINASE-C; SYNAPTOSOME-ASSOCIATED PROTEIN; TYROSINE PHOSPHORYLATION; NEUROTRANSMITTER RELEASE; DIFFERENTIAL PHOSPHORYLATION; DEPENDENT PHOSPHORYLATION; DIRECTED DIFFERENTIATION; POSSIBLE INVOLVEMENT; PRL PHOSPHATASES; CATALYTIC DOMAIN AB There is an urgent need to develop novel treatments to counter Botulinum neurotoxin (BoNT) poisoning. Currently, the majority of BoNT drug development efforts focus on directly inhibiting the proteolytic components of BoNT, i.e. light chains (LC). Although this is a rational approach, previous research has shown that LCs are extremely difficult drug targets and that inhibiting multi-serotype BoNTs with a single LC inhibitor may not be feasible. An alternative approach would target neuronal pathways involved in intoxication/recovery, rather than the LC itself. Phosphorylation-related mechanisms have been implicated in the intoxication pathway( s) of BoNTs. However, the effects of phosphatase inhibitors upon BoNT activity in the physiological target of BoNTs, i.e. motor neurons, have not been investigated. In this study, a small library of phosphatase inhibitors was screened for BoNT antagonismin the context of mouse embryonic stem cell-derived motor neurons (ES-MNs). Four inhibitors were found to function as BoNT/A antagonists. Subsequently, we confirmed that these inhibitors protect against BoNT/A in a dose-dependent manner in human ES-MNs. Additionally, these compounds provide protection when administered in post-intoxication scenario. Importantly, the inhibitors were also effective against BoNT serotypes B and E. To the best of our knowledge, this is the first study showing phosphatase inhibitors as broad-spectrum BoNT antagonists. C1 [Kiris, Erkan] Geneva Fdn, Tacoma, WA 98402 USA. [Kiris, Erkan; Nuss, Jonathan E.; Wanner, Laura M.; Cazares, Lisa; Du, Hao T.; Gomba, Glenn Y.; Panchal, Rekha G.; Kane, Christopher D.; Bavari, Sina] US Army, Med Res Inst Infect Dis, Dept Mol & Translat Sci, Frederick, MD USA. [Kiris, Erkan; Tessarollo, Lino] NCI, Ctr Canc Res, Mouse Canc Genet Program, Frederick, MD 21701 USA. [Stanford, Stephanie M.; Maestre, Michael F.; Bottini, Nunzio] La Jolla Inst Allergy & Immunol, Div Cellular Biol, La Jolla, CA USA. [Burnett, James C.] NCI, Leidos Biomed Res Inc, CDDG, Frederick, MD 21701 USA. [Burnett, James C.; Gussio, Rick] NCI, CDDG, Dev Therapeut Program, Frederick, MD 21701 USA. [Tessarollo, Lino] Henry M Jackson Fdn, Bethesda, MD USA. [Kane, Christopher D.] US Army, Med Res & Mat Command, TATRC, DoD Biotechnol High Performance Comp Software App, Frederick, MD USA. RP Kiris, E (reprint author), Geneva Fdn, Tacoma, WA 98402 USA. EM erkan.kiris@nih.gov; sina.bavari.civ@mail.mil FU Defense Threat Reduction Agency; National Institutes of Health [4R33AI101387-03]; National Cancer Institute (NCI), National Institutes of Health (NIH) [HHSN261200800001E]; Intramural Research Program of the NCI, Center for Cancer Research, NIH; Leidos Biomedical Research, Inc. FX This research was supported by grants from the Defense Threat Reduction Agency and National Institutes of Health (4R33AI101387-03). For JCB this project has been funded in whole or in part with federal funds from the National Cancer Institute (NCI), National Institutes of Health (NIH), under contract no. HHSN261200800001E. LT has been supported by the Intramural Research Program of the NCI, Center for Cancer Research, NIH. Leidos Biomedical Research, Inc. provided support in the form of salary for author JCB, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific role of this author is articulated in the 'author contributions' section. NR 87 TC 2 Z9 2 U1 0 U2 8 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUN 10 PY 2015 VL 10 IS 6 AR e0129264 DI 10.1371/journal.pone.0129264 PG 18 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CK1PO UT WOS:000355979500135 PM 26061731 ER PT J AU Friedlander, AM AF Friedlander, Arthur M. TI Management of Potential Bioterrorism-Related Conditions SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter ID ANTHRAX C1 US Army, Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Friedlander, AM (reprint author), US Army, Med Res Inst Infect Dis, Frederick, MD 21702 USA. EM arthur.m.friedlander.civ@mail.mil NR 3 TC 0 Z9 0 U1 4 U2 974 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 EI 1533-4406 J9 NEW ENGL J MED JI N. Engl. J. Med. PD JUN 4 PY 2015 VL 372 IS 23 BP 2272 EP 2272 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA CK1GK UT WOS:000355955100029 PM 26039617 ER PT J AU Venkatesan, MM Van de Verg, LL AF Venkatesan, Malabi M. Van de Verg, Lillian L. TI Combination vaccines against diarrheal diseases SO HUMAN VACCINES & IMMUNOTHERAPEUTICS LA English DT Review DE combination; diarrhea; ETEC; Shigella; vaccines ID ENTEROTOXIGENIC ESCHERICHIA-COLI; INFLUENZAE-TYPE-B; GLOBAL ENTERIC MULTICENTER; SHIGELLA-FLEXNERI 2A; HEAT-LABILE TOXIN; DIPHTHERIA-TETANUS-PERTUSSIS; INACTIVATED POLIO VACCINE; TOXOID CONJUGATE VACCINE; NON-TYPHOIDAL SALMONELLA; LOW-INCOME COUNTRIES AB Diarrheal diseases remain a leading cause of global childhood mortality and morbidity. Several recent epidemiological studies highlight the rate of diarrheal diseases in different parts of the world and draw attention to the impact on childhood growth and survival. Despite the well-documented global burden of diarrheal diseases, currently there are no combination diarrheal vaccines, only licensed vaccines for rotavirus and cholera, and Salmonella typhi-based vaccines for typhoid fever. The recognition of the impact of diarrheal episodes on infant growth, as seen in resource-poor countries, has spurred action from governmental and non-governmental agencies to accelerate research toward affordable and effective vaccines against diarrheal diseases. Both travelers and children in endemic countries will benefit from a combination diarrheal vaccine, but it can be argued that the greater proportion of any positive impact will be on the public health status of the latter. The history of combination pediatric vaccines indicate that monovalent or single disease vaccines are typically licensed first prior to formulation in a combination vaccine, and that the combinations themselves undergo periodic revision in response to need for improvement in safety or potential for wider coverage of important pediatric pathogens. Nevertheless combination pediatric vaccines have proven to be an effective tool in limiting or eradicating communicable childhood diseases worldwide. The landscape of diarrheal vaccine candidates indicates that there now several in active development that offer options for potential testing of combinations to combat those bacterial and viral pathogens responsible for the heaviest disease burdenrotavirus, ETEC, Shigella, Campylobacter, V. cholera and Salmonella. C1 [Venkatesan, Malabi M.] Walter Reed Army Inst Res, Bacterial Dis Branch, Silver Spring, MD 20910 USA. [Van de Verg, Lillian L.] PATH, Enter Vaccine Initiat, Vaccine Dev Global Program, Washington, DC USA. RP Venkatesan, MM (reprint author), Walter Reed Army Inst Res, Bacterial Dis Branch, Silver Spring, MD 20910 USA. EM malabi.venkatesan@us.army.mil NR 161 TC 2 Z9 2 U1 6 U2 15 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 2164-5515 EI 2164-554X J9 HUM VACC IMMUNOTHER JI Human Vaccines Immunother. PD JUN 3 PY 2015 VL 11 IS 6 BP 1434 EP 1448 DI 10.4161/21645515.2014.986984 PG 15 WC Biotechnology & Applied Microbiology; Immunology SC Biotechnology & Applied Microbiology; Immunology GA CK7QI UT WOS:000356426800033 PM 25891647 ER PT J AU Wang, G Pandey, R Karna, SP AF Wang, Gaoxue Pandey, Ravindra Karna, Shashi P. TI Atomically Thin Group V Elemental Films: Theoretical Investigations of Antimonene Allotropes SO ACS APPLIED MATERIALS & INTERFACES LA English DT Article DE 2D materials; antimonene; electronic properties; Raman spectra; STM ID BLACK PHOSPHORUS; SEMICONDUCTOR; GRAPHENE AB Group V elemental monolayers including phosphorene are emerging as promising 2D materials with semiconducting electronic properties. Here, we present the results of first-principles calculations on stability, mechanical and electronic properties of 2D antimony (Sb), antimonene. Our calculations show that free-standing alpha and beta allotropes of antimonene are stable and semiconducting. The a-Sb has a puckered structure with two atomic sublayers and beta-Sb has a buckled hexagonal lattice. The calculated Raman spectra and STM images have distinct features thus facilitating characterization of both allotropes. The beta-Sb has nearly isotropic mechanical properties, whereas alpha-Sb shows strongly anisotropic characteristics. An indirect-direct band gap transition is expected with moderate tensile strains applied to the monolayers, which opens up the possibility of their applications in optoelectronics. C1 [Wang, Gaoxue; Pandey, Ravindra] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. [Karna, Shashi P.] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Pandey, R (reprint author), Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. EM pandey@mtu.edu; shashi.p.karna.civ@mail.mil RI Wang, Gaoxue/C-9492-2017 OI Wang, Gaoxue/0000-0003-2539-3405 FU Army Research Office [W911NF-14-2-0088] FX RAMA and Superior, high performance computing clusters at Michigan Technological University, were used in obtaining results presented in this paper. Support from Dr. S. Gowtham is gratefully acknowledged. This research was partially supported by the Army Research Office through Grant W911NF-14-2-0088. NR 45 TC 34 Z9 34 U1 23 U2 105 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1944-8244 J9 ACS APPL MATER INTER JI ACS Appl. Mater. Interfaces PD JUN 3 PY 2015 VL 7 IS 21 BP 11490 EP 11496 DI 10.1021/acsami.5b02441 PG 7 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA CK0JO UT WOS:000355891700055 PM 25955131 ER PT J AU Thompson, T Sharafi, A Johannes, MD Huq, A Allen, JL Wolfenstine, J Sakamoto, J AF Thompson, Travis Sharafi, Asma Johannes, Michelle D. Huq, Ashfia Allen, Jan L. Wolfenstine, Jeff Sakamoto, Jeff TI A Tale of Two Sites: On Defining the Carrier Concentration in Garnet-Based Ionic Conductors for Advanced Li Batteries SO ADVANCED ENERGY MATERIALS LA English DT Article DE batteries; garnet; ionic conductivity; neutron diffraction; solid electrolytes ID RUBIDIUM SILVER-IODIDE; SOLID-ELECTROLYTE; LITHIUM GARNETS; ALPHA-AGI; CONDUCTIVITY; LI7LA3ZR2O12; DISORDER; OXIDES; SB; AL AB Solid electrolytes based on the garnet crystal structure have recently been identified as a promising material to enable advance Li battery cell chemistries because of the unprecedented combination of high ionic conductivity and electrochemical stability against metallic Li. To better understand the mechanisms that give rise to high conductivity, the goal of this work is to correlate Li site occupancy with Li-ion transport. Toward this goal, the Li site occupancy is studied in cubic garnet as a function of Li concentration over the compositions range: Li7-xLa3Zr2-xTaxO12 (x = 0.5, 0.75, and 1.5). The distribution of Li between the two interstitial sites (24d and 96h) is determined using neutron and synchrotron diffraction. The bulk conductivity is measured on >97% relative density polycrystalline specimens to correlate Li-ion transport as a function of Li site occupancy. It is determined that the conductivity changes nonlinearly with the occupancy of the octahedral (96h) Li site. It is shown that the effective carrier concentration is dependent on the Li site occupancy and suggests that this is a consequence of significant carrier-carrier coulombic interactions. Furthermore, the observation of maximum conductivity near Li = 6.5 mol is explained. C1 [Thompson, Travis; Sharafi, Asma; Sakamoto, Jeff] Univ Michigan, Dept Mech Engn, GG Brown Lab, Ann Arbor, MI 48109 USA. [Johannes, Michelle D.] Naval Res Lab, Ctr Computat Mat Sci, Anacostia, VA 20375 USA. [Huq, Ashfia] Oak Ridge Natl Lab, Spallat Neutron Source, Oak Ridge, TN 37831 USA. [Allen, Jan L.; Wolfenstine, Jeff] Army Res Lab, RDRL SED C, Adelphi, MD 20783 USA. RP Sakamoto, J (reprint author), Univ Michigan, Dept Mech Engn, GG Brown Lab, 2350 Hayward Ave, Ann Arbor, MI 48109 USA. EM jeffsaka@umich.edu RI Huq, Ashfia/J-8772-2013 OI Huq, Ashfia/0000-0002-8445-9649 FU Revolutionary Materials for Solid State Energy Conversion, an Energy Frontier Research Center - U.S. Department of Energy, Office of Science, Office of Basic Energy Science [DE-SC001054]; U.S. Army Research Laboratory (ARL); Office of Naval Research through the Naval Research Laboratory's Basic Research Program; Scientific User Facilities Division, Office of Basic Energy Sciences, U.S. Department of Energy FX T.T., A.S., and J.S. would like to acknowledge support from the Revolutionary Materials for Solid State Energy Conversion, an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science, Office of Basic Energy Science under Award No. DE-SC001054. J.W. and J.L.A. would like to acknowledge support of the U.S. Army Research Laboratory (ARL). Funding for M.D.J. was provided by the Office of Naval Research through the Naval Research Laboratory's Basic Research Program. The diffraction research conducted at the Spallation Neutron Source at Oak Ridge National Laboratory and the Advanced Photon Source at Argonne National Laboratory was sponsored by the Scientific User Facilities Division, Office of Basic Energy Sciences, U.S. Department of Energy. NR 58 TC 14 Z9 14 U1 22 U2 135 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY SN 1614-6832 EI 1614-6840 J9 ADV ENERGY MATER JI Adv. Energy Mater. PD JUN 3 PY 2015 VL 5 IS 11 AR 1500096 DI 10.1002/aenm.201500096 PG 9 WC Chemistry, Physical; Energy & Fuels; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Energy & Fuels; Materials Science; Physics GA CJ8LU UT WOS:000355753300007 ER PT J AU Hoyer, MV McNabb, T Allen, M Netherland, MD AF Hoyer, Mark V. McNabb, Terry Allen, Micheal Netherland, Michael D. TI IMPROVING COMMUNICATION/COOPERATION AMONG AQUATIC PROFESSIONAL SOCIETIES SO FISHERIES LA English DT News Item C1 [Hoyer, Mark V.; Allen, Micheal] Univ Florida, IFAS, Sch Forest Resources & Conservat, Fisheries & Aquat Sci, Gainesville, FL 32653 USA. [McNabb, Terry] Aquatechnex LLC, Couer Dalene, ID 83816 USA. [Netherland, Michael D.] USACE ERDC Environm Lab, Ctr Aquat & Invas Plants, Gainesville, FL 32653 USA. RP Hoyer, MV (reprint author), Univ Florida, IFAS, Sch Forest Resources & Conservat, Fisheries & Aquat Sci, Gainesville, FL 32653 USA. EM mvhoyer@ufl.edu; tmcnabb@aquatechnex.com; msal@ufl.edu; mdnether@ufl.edu NR 1 TC 0 Z9 0 U1 0 U2 1 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 0363-2415 EI 1548-8446 J9 FISHERIES JI Fisheries PD JUN 3 PY 2015 VL 40 IS 6 BP 248 EP 251 PG 4 WC Fisheries SC Fisheries GA CJ6NB UT WOS:000355609400002 ER PT J AU Johansen, LM DeWald, LE Shoemaker, CJ Hoffstrom, BG Lear-Rooney, CM Stossel, A Nelson, E Delos, SE Simmons, JA Grenier, JM Pierce, LT Pajouhesh, H Lehar, J Hensley, LE Glass, PJ White, JM Olinger, GG AF Johansen, Lisa M. DeWald, Lisa Evans Shoemaker, Charles J. Hoffstrom, Benjamin G. Lear-Rooney, Calli M. Stossel, Andrea Nelson, Elizabeth Delos, Sue E. Simmons, James A. Grenier, Jill M. Pierce, Laura T. Pajouhesh, Hassan Lehar, Joseph Hensley, Lisa E. Glass, Pamela J. White, Judith M. Olinger, Gene G. TI A screen of approved drugs and molecular probes identifies therapeutics with anti-Ebola virus activity SO SCIENCE TRANSLATIONAL MEDICINE LA English DT Article ID NIEMANN-PICK C1; CELL ENTRY; HEMORRHAGIC-FEVER; FILOVIRUS ENTRY; MOUSE MODEL; GLYCOPROTEIN; INFECTION; BINDING; FUSION; ACID AB Currently, no approved therapeutics exist to treat or prevent infections induced by Ebola viruses, and recent events have demonstrated an urgent need for rapid discovery of new treatments. Repurposing approved drugs for emerging infections remains a critical resource for potential antiviral therapies. We tested similar to 2600 approved drugs and molecular probes in an in vitro infection assay using the type species, Zaire ebolavirus. Selective antiviral activity was found for 80 U.S. Food and Drug Administration-approved drugs spanning multiple mechanistic classes, including selective estrogen receptor modulators, antihistamines, calcium channel blockers, and antidepressants. Results using an in vivo murine Ebola virus infection model confirmed the protective ability of several drugs, such as bepridil and sertraline. Viral entry assays indicated that most of these antiviral drugs block a late stage of viral entry. By nature of their approved status, these drugs have the potential to be rapidly advanced to clinical settings and used as therapeutic countermeasures for Ebola virus infections. C1 [Johansen, Lisa M.; Hoffstrom, Benjamin G.; Grenier, Jill M.; Pierce, Laura T.; Pajouhesh, Hassan; Lehar, Joseph] Horizon Discovery Inc, Cambridge, MA 02142 USA. [DeWald, Lisa Evans; Lear-Rooney, Calli M.; Stossel, Andrea; Hensley, Lisa E.; Glass, Pamela J.; Olinger, Gene G.] US Army Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Shoemaker, Charles J.; Nelson, Elizabeth; Delos, Sue E.; Simmons, James A.; White, Judith M.] Univ Virginia, Charlottesville, VA 22908 USA. [Lehar, Joseph] Boston Univ, Bioinformat Program, Boston, MA 02215 USA. RP Olinger, GG (reprint author), NIAID, Integrated Res Facil, Div Clin Res, B-8200 Res Plaza, Frederick, MD 21702 USA. EM gene.olinger@nih.gov FU Defense Threat Reduction Agency project [4.10007_08_RD_B]; USAMRIID [W81XWH-08-0051]; NIH [U54 AI057168]; DTRA [W81XWH-12-P-0007]; National Research Council Research Associateship Award at USAMRIID FX This work is funded by Defense Threat Reduction Agency project 4.10007_08_RD_B awarded to G.G.O. and subcontract (W81XWH-08-0051) awarded to L.M.J. from USAMRIID and an NIH grant U54 AI057168 and DTRA subcontract W81XWH-12-P-0007 awarded to J.M.W. This research was performed while L.E.D. held a National Research Council Research Associateship Award at USAMRIID. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army. NR 57 TC 18 Z9 18 U1 7 U2 20 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 1946-6234 EI 1946-6242 J9 SCI TRANSL MED JI Sci. Transl. Med. PD JUN 3 PY 2015 VL 7 IS 290 AR 290ra89 DI 10.1126/scitranslmed.aaa5597 PG 13 WC Cell Biology; Medicine, Research & Experimental SC Cell Biology; Research & Experimental Medicine GA CJ6WI UT WOS:000355635500007 PM 26041706 ER PT J AU Oliveira, F Rowton, E Aslan, H Gomes, R Castrovinci, PA Alvarenga, PH Abdeladhim, M Teixeira, C Meneses, C Kleeman, LT Guimaraes-Costa, AB Rowland, TE Gilmore, D Doumbia, S Reed, SG Lawyer, PG Andersen, JF Kamhawi, S Valenzuela, JG AF Oliveira, Fabiano Rowton, Edgar Aslan, Hamide Gomes, Regis Castrovinci, Philip A. Alvarenga, Patricia H. Abdeladhim, Maha Teixeira, Clarissa Meneses, Claudio Kleeman, Lindsey T. Guimaraes-Costa, Anderson B. Rowland, Tobin E. Gilmore, Dana Doumbia, Seydou Reed, Steven G. Lawyer, Phillip G. Andersen, John F. Kamhawi, Shaden Valenzuela, Jesus G. TI A sand fly salivary protein vaccine shows efficacy against vector-transmitted cutaneous leishmaniasis in nonhuman primates SO SCIENCE TRANSLATIONAL MEDICINE LA English DT Article ID DELAYED-TYPE HYPERSENSITIVITY; PHLEBOTOMUS-PAPATASI; VISCERAL LEISHMANIASIS; IMMUNE-RESPONSE; MAJOR INFECTION; LUTZOMYIA-LONGIPALPIS; CYTOKINE PRODUCTION; PROTECTION; FLIES; ANTIGEN AB Currently, there are no commercially available human vaccines against leishmaniasis. In rodents, cellular immunity to salivary proteins of sand fly vectors is associated to protection against leishmaniasis, making them worthy targets for further exploration as vaccines. We demonstrate that nonhuman primates (NHP) exposed to Phlebotomus duboscqi uninfected sand fly bites or immunized with salivary protein PdSP15 are protected against cutaneous leishmaniasis initiated by infected bites. Uninfected sand fly-exposed and 7 of 10 PdSP15-immunized rhesus macaques displayed a significant reduction in disease and parasite burden compared to controls. Protection correlated to the early appearance of Leishmania-specific CD4(+)IFN-gamma(+) lymphocytes, suggesting that immunity to saliva or PdSP15 augments the host immune response to the parasites while maintaining minimal pathology. Notably, the 30% unprotected PdSP15-immunized NHP developed neither immunity to PdSP15 nor an accelerated Leishmania-specific immunity. Sera and peripheral blood mononuclear cells from individuals naturally exposed to P. duboscqi bites recognized PdSP15, demonstrating its immunogenicity in humans. PdSP15 sequence and structure show no homology to mammalian proteins, further demonstrating its potential as a component of a vaccine for human leishmaniasis. C1 [Oliveira, Fabiano; Aslan, Hamide; Gomes, Regis; Castrovinci, Philip A.; Abdeladhim, Maha; Teixeira, Clarissa; Meneses, Claudio; Kleeman, Lindsey T.; Guimaraes-Costa, Anderson B.; Gilmore, Dana; Kamhawi, Shaden; Valenzuela, Jesus G.] NIAID, Vector Mol Biol Sect, Lab Malaria & Vector Res, NIH, Rockville, MD 20852 USA. [Rowton, Edgar; Rowland, Tobin E.; Lawyer, Phillip G.] Walter Reed Army Inst Res, Dept Entomol, Silver Spring, MD 20910 USA. [Gomes, Regis; Teixeira, Clarissa] Fundacao Oswaldo Cruz FIOCRUZ, Ctr Pesquisas Goncalo Moniz CPqGM, BR-40296710 Salvador, BA, Brazil. [Alvarenga, Patricia H.] Univ Fed Rio de Janeiro, Inst Bioquim Med, Lab Bioquim Resposta Estresse, BR-21941902 Rio De Janeiro, Brazil. [Alvarenga, Patricia H.] Univ Fed Rio de Janeiro, INCT EM, BR-21941902 Rio De Janeiro, Brazil. [Doumbia, Seydou] Univ Bamako, Fac Med Pharm & Odontostomatol, Bamako 1805, Mali. [Reed, Steven G.] Infectious Dis Res Inst, Seattle, WA 98102 USA. [Andersen, John F.] NIAID, Vector Biol Sect, Lab Malaria & Vector Res, NIH, Rockville, MD 20852 USA. RP Valenzuela, JG (reprint author), NIAID, Vector Mol Biol Sect, Lab Malaria & Vector Res, NIH, Rockville, MD 20852 USA. EM skamhawi@niaid.nih.gov; jvalenzuela@niaid.nih.gov FU Intramural Research Program at the NIAID, NIH; Grand Challenges Explorations grant from the Bill and Melinda Gates Foundation; Science Without Borders Fellowship from the National Council for Scientific and Technological Development (CNPq)-Brazil FX Support for this work was provided by the Intramural Research Program at the NIAID, NIH, and by the Grand Challenges Explorations grant from the Bill and Melinda Gates Foundation. A.B.G.-C. was partially funded by a Science Without Borders Fellowship from the National Council for Scientific and Technological Development (CNPq)-Brazil. Fundacao de Amparo a Pesquisa do Rio de Janeiro Carlos Chagas Filho and Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (P.H.A.). NR 59 TC 13 Z9 13 U1 1 U2 13 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 1946-6234 EI 1946-6242 J9 SCI TRANSL MED JI Sci. Transl. Med. PD JUN 3 PY 2015 VL 7 IS 290 AR 290ra90 DI 10.1126/scitranslmed.aaa3043 PG 12 WC Cell Biology; Medicine, Research & Experimental SC Cell Biology; Research & Experimental Medicine GA CJ6WI UT WOS:000355635500009 PM 26041707 ER PT J AU Ausset, S Glassberg, E Nadler, R Sunde, G Cap, AP Hoffmann, C Plang, S Sailliol, A AF Ausset, Sylvain Glassberg, Elon Nadler, Roy Sunde, Geir Cap, Andrew P. Hoffmann, Clement Plang, Soryapong Sailliol, Anne TI Tranexamic acid as part of remote damage-control resuscitation in the prehospital setting: A critical appraisal of the medical literature and available alternatives SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article; Proceedings Paper CT 4th Annual Conference on Remote Damage Control Resuscitation (RDCR) CY JUN 09-11, 2014 CL Bergen, NORWAY DE Tranexamic acid; hemorrhage; military; prehospital; resuscitation ID COMBAT CASUALTY CARE; RANDOMIZED CONTROLLED-TRIAL; OPERATION-ENDURING-FREEDOM; RECOMBINANT FACTOR VIIA; TRAUMA PATIENTS; BLOOD-TRANSFUSION; DEFENSE FORCES; MILITARY; INJURY; DEATH AB BACKGROUND: Hemorrhage remains the leading cause of preventable trauma-associated mortality. Interventions that improve prehospital hemorrhage control and resuscitation are needed. Tranexamic acid (TXA) has recently been shown to reduce mortality in trauma patients when administered upon hospital admission, and available data suggest that early dosing confers maximum benefit. Data regarding TXA implementation in prehospital trauma care and analyses of alternatives are lacking. This review examines the available evidence that would inform selection of hemostatic interventions to improve outcomes in prehospital trauma management as part of a broader strategy of ''remote damage-control resuscitation" (RDCR). METHODS: The medical literature available concerning both the safety and the efficacy of TXA and other hemostatic agents was reviewed. RESULTS: TXA use in surgery was studied in 129 randomized controlled trials, and a meta-analysis was identified. More than 800,000 patients were followed up in large cohort study. In trauma, a large randomized controlled trial, the CRASH-2 study, recruited more than 20,000 patients, and two cohort studies studied more than 1,000 war casualties. In the prehospital setting, the US, French, British, and Israeli militaries as well as the British, Norwegian, and Israeli civilian ambulance services have implemented TXA use as part of RDCR policies. CONCLUSION: Available data support the efficacy and the safety of TXA. High-level evidence supports its use in trauma and strongly suggests that its implementation in the prehospital setting offers a survival advantage to many patients, particularly when evacuation to surgical care may be delayed. TXA plays a central role in the development of RDCR strategies. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved. C1 [Ausset, Sylvain] Percy Mil Hosp, Dept Anesthesiol & Intens Care, 101 Ave Henri Barbusse,BP 406, F-92141 Clamart, France. [Plang, Soryapong; Sailliol, Anne] Ctr Transfus Sanguine Armees, Rue Raoul Batany, Clamart, France. [Hoffmann, Clement] Ecole Val de Grace, French Mil Hlth Serv Acad, Paris, France. [Glassberg, Elon; Nadler, Roy] Israel Def Forces Med Corps, Surg Gen Headquarters, Trauma & Combat Med Branch, Ramat Gan, Israel. [Sunde, Geir] Norwegian Air Ambulance Fdn, Drobak, Norway. [Cap, Andrew P.] US Army, Blood Res Program, Inst Surg Res, Jbsa Ft Sam Houston, TX USA. RP Ausset, S (reprint author), Percy Mil Hosp, Dept Anesthesiol & Intens Care, 101 Ave Henri Barbusse,BP 406, F-92141 Clamart, France. EM sylvain.ausset@gmail.com OI Ausset, Sylvain/0000-0001-8345-1058 NR 49 TC 13 Z9 13 U1 1 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD JUN PY 2015 VL 78 SU 1 BP S70 EP S75 DI 10.1097/TA.0000000000000640 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA DJ7QU UT WOS:000374406700012 PM 26002268 ER PT J AU Cap, AP Pidcoke, HF DePasquale, M Rappold, JF Glassberg, E Eliassen, HS Bjerkvig, CK Fosse, TK Kane, S Thompson, P Sikorski, R Miles, E Fisher, A Ward, KR Spinella, PC Strandenes, G AF Cap, Andrew P. Pidcoke, Heather F. DePasquale, Marc Rappold, Joseph F. Glassberg, Elon Eliassen, Hakon S. Bjerkvig, Christopher K. Fosse, Theodor K. Kane, Shawn Thompson, Patrick Sikorski, Robert Miles, Ethan Fisher, Andrew Ward, Kevin R. Spinella, Philip C. Strandenes, Geir TI Blood far forward: Time to get moving! SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article; Proceedings Paper CT 4th Annual Conference on Remote Damage Control Resuscitation (RDCR) CY JUN 09-11, 2014 CL Bergen, NORWAY DE Hemorrhage; shock; resuscitation; blood transfusion; whole blood ID COMBAT CASUALTY CARE; DAMAGE CONTROL RESUSCITATION; WHOLE-BLOOD; BATTLEFIELD; TRANSFUSION; HEMORRHAGE; SURGERY; SOMALIA; DEATH AB In planning for future contingencies, current problems often crowd out historical perspective and planners often turn to technological solutions to bridge gaps between desired outcomes and the reality of recent experience. The US Military, North Atlantic Treaty Organization, and other allies are collectively taking stock of 10-plus years of medical discovery and rediscovery of combat casualty care after the wars in Iraq and Afghanistan. There has been undeniable progress in the treatment of combat wounded during the course of the conflicts in Southwest Asia, but continued efforts are required to improve hemorrhage control and provide effective prehospital resuscitation that treats both coagulopathy and shock. This article presents an appraisal of the recent evolution in medical practice in historical context and suggests how further gains in far forward resuscitation might be achieved using existing technology and methods based on whole-blood transfusion while research on new approaches continues. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved.) C1 [Cap, Andrew P.; Pidcoke, Heather F.] US Army Inst Surg Res, Coagulat Blood Res Program, Houston, TX USA. [DePasquale, Marc] Deployment Med Int, Washington, DC USA. [Rappold, Joseph F.] Temple Univ, Sch Med, Dept Surg, Philadelphia, PA 19122 USA. [Glassberg, Elon] Israel Def Forces, Surg Gen HW, Trauma & Combat Med Branch, Ramat Gan, Israel. [Eliassen, Hakon S.; Strandenes, Geir] Norwegian Naval Special Operat Commando, Bergen, Norway. [Bjerkvig, Christopher K.; Fosse, Theodor K.] Haukeland Hosp, Dept Anaesthesia & Intens Care, N-5021 Bergen, Norway. [Kane, Shawn] US Army Special Operat Command, Ft Bragg, NC USA. [Thompson, Patrick] Adv Tact & Emergency Med, London, England. [Sikorski, Robert] Univ Maryland, Dept Anesthesiol, Div Trauma Anesthesiol,Sch Med, Med Director Perfus Cell Salvage Serv,R Adams Cow, Baltimore, MD 21201 USA. [Miles, Ethan; Fisher, Andrew] Ranger Regiment, Ft Benning, GA USA. [Ward, Kevin R.] Univ Michigan, Dept Emergency Med, Michigan Ctr Integrat Res Crit Care, Ann Arbor, MI 48109 USA. [Spinella, Philip C.] Washington Univ, Dept Pediat, Div Pediat Crit Care, St Louis, MO 63130 USA. [Strandenes, Geir] Haukeland Hosp, Dept Immunol Transfus Med, N-5021 Bergen, Norway. RP Strandenes, G (reprint author), Haukeland Hosp, Dept Immunol Transfus Med, N-5021 Bergen, Norway.; Strandenes, G (reprint author), Norwegian Naval Special Operat, Bergen, Norway. EM geir@docfish.no RI Fisher, Andrew/M-8683-2015 OI Fisher, Andrew/0000-0003-1994-7774 NR 26 TC 3 Z9 3 U1 1 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD JUN PY 2015 VL 78 SU 1 BP S2 EP S6 DI 10.1097/TA.0000000000000626 PG 5 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA DJ7QU UT WOS:000374406700002 PM 26002259 ER PT J AU Pidcoke, HF Isbell, CL Herzig, MC Fedyk, CG Schaffer, BS Chung, KK White, CE Wolf, SE Wade, CE Cap, AP AF Pidcoke, Heather F. Isbell, Claire L. Herzig, Maryanne C. Fedyk, Chriselda G. Schaffer, Beverly S. Chung, Kevin K. White, Christopher E. Wolf, Steven E. Wade, Charles E. Cap, Andrew P. TI Acute blood loss during burn and soft tissue excisions: An observational study of blood product resuscitation practices and focused review SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article; Proceedings Paper CT 4th Annual Conference on Remote Damage Control Resuscitation (RDCR) CY JUN 09-11, 2014 CL Bergen, NORWAY DE Damage control resuscitation; burn excision; soft tissue excision; acute traumatic coagulopathy; severe hemorrhage ID ACUTE TRAUMATIC COAGULOPATHY; COMBAT CASUALTY CARE; IMPROVED SURVIVAL; TRANSFUSION; COAGULATION; MORTALITY; INJURY; RATIO; TRIAL; MULTICENTER AB BACKGROUND: Many military and civilian centers have shifted to a damage-control resuscitation approach, focused on providing oxygen-carrying capacity while simultaneously mitigating coagulopathy with a balanced ratio of platelets and plasma to red blood cells. It is unclear to what degree this strategy is used during burn or soft tissue excision. Here, we characterized blood product transfusion during burn and soft tissue surgery and reviewed the published literature regarding intraoperative coagulation changes. We hypothesized that blood product resuscitation during burn and soft tissue excision is not hemostatic and would be insufficient to address hemorrhage-induced coagulopathy. METHODS: Consented adult patients were enrolled into an institutional review board-approved prospective observational study. Number, component type, volume, and age of the blood products transfused were recorded during burn excision/grafting or soft tissue debridement. Component bags (packed red blood cells, fresh frozen plasma, platelets, and cryoprecipitate) were collected, and the remaining sample was harvested from the bag and tubing. Aliquots of 1/1,000th the original volume of each blood product were obtained and combined, producing an amalgam sample containing the same ratio of product transfused. Platelet count, rotational thromboelastometry, and impedance aggregometry were measured. Significance was set at p < 0.05. RESULTS: Amalgamated transfusate samples produced abnormally weak clots (p <= 0.001) particularly if they did not contain platelets. Clot strength (48.8 [2.6] mm; reference range, 49-71 mm) for platelet-containing amalgams was below the lower limit of the reference range despite platelet-red blood cell ratios greater than 1:1. Platelet aggregation was abnormally low; transfused platelets were functionally inferior to native platelets. CONCLUSION: Our study and focused review demonstrate that further work is needed to fully understand the needs of patients undergoing tissue excision. The three studies reviewed and the results of our observational work suggest that coagulopathy and thrombocytopenia may contribute to intraoperative hemorrhage. Blood product resuscitation during burn and soft tissue excision is not hemostatic. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved. C1 [Pidcoke, Heather F.; Herzig, Maryanne C.; Fedyk, Chriselda G.; Schaffer, Beverly S.; Chung, Kevin K.; White, Christopher E.; Cap, Andrew P.] US Army, Inst Surg Res, San Antonio, TX USA. [Isbell, Claire L.; Wolf, Steven E.] Univ Texas SW Med Ctr Dallas, Dept Surg, Dallas, TX 75390 USA. [Wade, Charles E.] Univ Texas Hlth Sci Ctr Houston, Dept Surg, Houston, TX 77030 USA. [Wade, Charles E.] Univ Texas Hlth Sci Ctr Houston, Ctr Translat Injury Res, Houston, TX 77030 USA. [Chung, Kevin K.; Cap, Andrew P.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Pidcoke, HF (reprint author), US Army, Coagulat & Blood Res Program, Inst Surg Res, 3650 Chambers Pass, Jbsa Ft Sam Houston, TX 78234 USA. EM heather.f.pidcoke2.civ@mail.mil FU NHLBI NIH HHS [U01 HL077863] NR 50 TC 2 Z9 2 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD JUN PY 2015 VL 78 SU 1 BP S39 EP S47 DI 10.1097/TA.0000000000000627 PG 9 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA DJ7QU UT WOS:000374406700007 PM 26002262 ER PT J AU Spinella, PC Frazier, E Pidcoke, HF Dietzen, DJ Pati, S Gorkun, O Aden, JK Norris, PJ Cap, AP AF Spinella, Philip C. Frazier, Elfaridah Pidcoke, Heather F. Dietzen, Dennis J. Pati, Shibani Gorkun, Oleg Aden, James K. Norris, Philip J. Cap, Andrew P. TI All plasma products are not created equal: Characterizing differences between plasma products SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article; Proceedings Paper CT 4th Annual Conference on Remote Damage Control Resuscitation (RDCR) CY JUN 09-11, 2014 CL Bergen, NORWAY DE Plasma quality; thrombin; microparticle; hemostasis; solvent detergent ID FRESH-FROZEN PLASMA; RED-BLOOD-CELLS; CLINICAL-RELEVANCE; ENDOTHELIAL-CELLS; LIQUID PLASMA; MICROPARTICLES; PLATELETS; RESUSCITATION; LEUKOCYTE; PERMEABILITY AB BACKGROUND: Plasma can be manufactured by multiple methods. Few studies have compared quality parameters between plasma products that may affect efficacy and safety. METHODS: Four different plasma products were analyzed to include fresh frozen plasma (FFP), liquid plasma (LP), solvent detergent plasma (SDP), and a spray-dried, solvent detergent-treated plasma (SD-SDP) at multiple time points of storage. Parameters measured included red blood cell, platelet, and white blood cell counts; microparticle phenotypes; thrombin generation; and thrombelastography. These parameters were compared in 10 samples of each product. RESULTS: SDP and SD-SDP contained the smallest number of residual cells compared with FFP and LP. Platelets were the most common residual cell in all products and were highest in LP. FFP contained the greatest number of residual red blood cells. Total microparticle counts were elevated in LP and FFP compared with SDP and SD-SDP. Cell-derived microparticles in both LP and FFP were mostly platelet in origin. Microparticle counts in SDP and SD-SDP were negligible. Thrombelastography results demonstrated similar thrombin, fibrinogen, and platelet function on Day 28 LP compared with Day 5 thawed FFP. Thrombin generation assays revealed that the total, lag time to, and peak thrombin formation were higher in SDP and SD-SDP compared with FFP and LP. All parameters in FFP and LP products were characterized by a large degree of variability. CONCLUSION: The differences in cellular, microparticle, and functional hemostatic parameters measured between plasma products have the potential to affect efficacy and safety. Further study is needed to elucidate the potential immune effects of the cellular and microparticle differences noted as well as the clinical implications of altered thrombin generation kinetics in SD products. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved. C1 [Spinella, Philip C.; Frazier, Elfaridah] Washington Univ, Dept Pediat, Div Crit Care, St Louis, MO 63130 USA. [Spinella, Philip C.; Dietzen, Dennis J.] Washington Univ, Dept Pediat, Lab Med, St Louis, MO 63130 USA. [Pidcoke, Heather F.; Aden, James K.; Cap, Andrew P.] US Army, Inst Surg Res, Brooke Army Med Ctr, San Antonio, TX USA. [Pati, Shibani; Norris, Philip J.] Blood Syst Res Inst, San Francisco, CA USA. [Pati, Shibani; Norris, Philip J.] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Gorkun, Oleg] Entegrion, Res Triangle Pk, NC USA. RP Norris, PJ (reprint author), Campus Box 8116,NWT 10th Floor,1 Childrens Pl, St Louis, MO 63110 USA. EM spinella_p@kids.wustl.edu NR 35 TC 6 Z9 6 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD JUN PY 2015 VL 78 SU 1 BP S18 EP S25 DI 10.1097/TA.0000000000000629 PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA DJ7QU UT WOS:000374406700004 PM 26002258 ER PT J AU Strandenes, G Austlid, I Apelseth, TO Hervig, TA Sommerfelt-Pettersen, J Herzig, MC Cap, AP Pidcoke, HF Kristoffersen, EK AF Strandenes, Geir Austlid, Ivar Apelseth, Torunn O. Hervig, Tor A. Sommerfelt-Pettersen, Jan Herzig, Maryanne C. Cap, Andrew P. Pidcoke, Heather F. Kristoffersen, Einar K. TI Coagulation function of stored whole blood is preserved for 14 days in austere conditions: A ROTEM feasibility study during a Norwegian antipiracy mission and comparison to equal ratio reconstituted blood SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article; Proceedings Paper CT 4th Annual Conference on Remote Damage Control Resuscitation (RDCR) CY JUN 09-11, 2014 CL Bergen, NORWAY DE Whole blood transfusion; austere environments; reconstituted whole blood; remote damage-control resuscitation; damage-control resuscitation ID DAMAGE CONTROL RESUSCITATION; IMPROVED SURVIVAL; TRANSFUSION; TRAUMA; REDUCTION AB BACKGROUND: Formulation of a medical preparedness plan for treating severely bleeding casualties during naval deployment is a significant challenge because of territory covered during most missions. The aim of this study was to evaluate the concept of "walking blood bank" as a supportable plan for supplying safe blood and blood products. METHODS: In 2013, the Royal Norwegian Navy conducted antipiracy operations from a frigate, beginning in the Gulf of Aden and ending in the Indian Ocean. Crews were on 24-hour emergency alert in preparation for an enemy assault on the frigate. Under an approved command protocol, a "walking blood bank," using crew blood donations, was established for use on board and on missions conducted in rigid-hulled inflatable boats, during which freeze-dried plasma and leukoreduced, group O low anti-A/anti-B titer, cold-stored whole blood were stored in Golden Hour Boxes. Data demonstrating the ability to collect, store, and provide whole blood were collected to establish feasibility of implementing a whole blood-focused remote damage-control resuscitation program aboard a naval vessel. In addition, ROTEM data were collected to demonstrate feasibility of performing this analysis on a large naval vessel and to also measure hemostatic efficacy of cold-stored leukoreduced whole blood (CWB) stored during a period of 14 days. ROTEM data on CWB was compared with reconstituted whole blood. RESULTS: Drills simulating massive transfusion activation were conducted, in which 2 U of warm fresh whole blood with platelet sparing leukoreduction were produced in 40 minutes, followed by collection of two additional units at 15-minute increments. The ROTEM machine performed well during ship-rolling, as shown by the overlapping calculated and measured mechanical piston movements measured by the ROTEM device. Error messages were recorded in 4 (1.5%) of 267 tests. CWB yielded reproducible ROTEM results demonstrating preserved fibrinogen function and platelet function for at least 3.5 weeks and 2 weeks, respectively. The frequency of ROTEM tests were as follows: EXTEM (n = 88), INTEM (n = 85), FIBTEM (n = 82), and APTEM (n = 12). CWB results were grouped. Compared with Days 0 to 2, EXTEM maximum clot firmness was significantly reduced, beginning on Days 10 to 14; however, results through that date remained within reference ranges and were comparable with the EXTEM maximum clot firmness for the reconstituted whole blood samples containing Day 5 room temperature-stored platelets. CONCLUSION: A "walking blood bank" can provide a balanced transfusion product to support damage-control resuscitation/remote damage-control resuscitation aboard a frigate in the absence of conventional blood bank products. ROTEM analysis is feasible to monitor damage-control resuscitation and blood product quality. ROTEM analysis was possible in challenging operational conditions. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved. C1 [Strandenes, Geir] Haukeland Hosp, Norwegian Naval Special Operat Commando, N-5021 Bergen, Norway. [Strandenes, Geir; Apelseth, Torunn O.; Hervig, Tor A.; Kristoffersen, Einar K.] Haukeland Hosp, Dept Immunol & Transfus Med, N-5021 Bergen, Norway. [Apelseth, Torunn O.] Haukeland Hosp, Lab Clin Biochem, N-5021 Bergen, Norway. [Austlid, Ivar] Royal Norwegian Navy, Maritime Logist, Bergen, Norway. [Sommerfelt-Pettersen, Jan] Norwegian Armed Forces Joint Med Serv, Sessvollmoen, Ullensaker, Norway. [Herzig, Maryanne C.; Cap, Andrew P.; Pidcoke, Heather F.] US Army, Inst Surg Res, Coagulat & Blood Res Program, San Antonio, TX USA. RP Strandenes, G (reprint author), Haukeland Hosp, Dept Immunol & Transfus Med, Jonas Liesvei 65, N-5021 Bergen, Norway. EM geir@docfish.no NR 15 TC 7 Z9 7 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD JUN PY 2015 VL 78 SU 1 BP S31 EP S38 DI 10.1097/TA.0000000000000628 PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA DJ7QU UT WOS:000374406700006 PM 26002261 ER PT J AU Watson, S AF Watson, Samuel TI American Carnage: Wounded Knee, 1890 SO NEW MEXICO HISTORICAL REVIEW LA English DT Book Review C1 [Watson, Samuel] US Mil Acad, West Point, NY 10996 USA. RP Watson, S (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU UNIV NEW MEXICO PI ALBUQUERQUE PA NEW MEXICO HISTORICAL REVIEW, 1013 MESA VISTA HALL, ALBUQUERQUE, NM 87131-1186 USA SN 0028-6206 J9 NEW MEX HIST REV JI N. M. Hist. Rev. PD SUM PY 2015 VL 90 IS 3 BP 401 EP 402 PG 2 WC History SC History GA DJ2QO UT WOS:000374050300024 ER PT J AU Trevelyan, AJ Muldoon, SF Merricks, EM Racca, C Staley, KJ AF Trevelyan, Andrew J. Muldoon, Sarah F. Merricks, Edward M. Racca, Claudia Staley, Kevin J. TI The Role of Inhibition in Epileptic Networks SO JOURNAL OF CLINICAL NEUROPHYSIOLOGY LA English DT Review DE epilepsy; seizure; GABA; interneuron; chloride ID TEMPORAL-LOBE EPILEPSY; GAP-JUNCTION BLOCKERS; HILAR SOMATOSTATIN INTERNEURONS; HIPPOCAMPAL PYRAMIDAL CELLS; MOSSY FIBER REORGANIZATION; DENTATE GRANULE CELLS; GABAERGIC NEURONS; PILOCARPINE MODEL; VISUAL-CORTEX; MOUSE MODEL AB Inhibition plays many roles in cortical circuits, including coordination of network activity in different brain rhythms and neuronal clusters, gating of activity, gain control, and dictating the manner in which activity flows through the network. This latter is particularly relevant to epileptic states, when extreme hypersynchronous discharges can spread across cortical territories. We review these different physiological and pathological roles and discuss how inhibition can be compromised and why this predisposes the network to seizures. C1 [Trevelyan, Andrew J.; Merricks, Edward M.; Racca, Claudia] Newcastle Univ, Sch Med, Inst Neurosci, Framlington Pl, Newcastle Upon Tyne NE2 2PP, Tyne & Wear, England. [Muldoon, Sarah F.] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA. [Muldoon, Sarah F.] US Army, Res Lab, Bethesda, MD USA. [Staley, Kevin J.] Massachusetts Gen Hosp, Neurol Res, Boston, MA 02114 USA. RP Trevelyan, AJ (reprint author), Newcastle Univ, Sch Med, Inst Neurosci, Framlington Pl, Newcastle Upon Tyne NE2 2PP, Tyne & Wear, England. EM andytrev@gmail.com FU Medical Research Council [MR/J013250/1] NR 100 TC 3 Z9 4 U1 4 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0736-0258 EI 1537-1603 J9 J CLIN NEUROPHYSIOL JI J. Clin. Neurophysiol. PD JUN PY 2015 VL 32 IS 3 BP 227 EP 234 PG 8 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA DD0DB UT WOS:000369589400007 PM 26035675 ER PT J AU Ndhlovu, LC D'Antoni, ML Ananworanich, J Byron, MM Chalermchai, T Sithinamsuwan, P Tipsuk, S Ho, E Slike, BM Schuetz, A Zhang, GX Agsalda-Garcia, M Shiramizu, B Shikuma, CM Valcour, VV AF Ndhlovu, Lishomwa C. D'Antoni, Michelle L. Ananworanich, Jintanat Byron, Mary Margaret Chalermchai, Thep Sithinamsuwan, Pasiri Tipsuk, Somporn Ho, Erika Slike, Bonnie M. Schuetz, Alexandra Zhang, Guangxiang Agsalda-Garcia, Melissa Shiramizu, Bruce Shikuma, Cecilia M. Valcour, Victor Valcour TI Loss of CCR2 Expressing Non-Classical Monocytes are Associated with Cognitive Impairment in Antiretroviral Therapy-Naive HIV-Infected Thais SO JOURNAL OF NEUROVIROLOGY LA English DT Meeting Abstract CT 13th International Symposium on NeuroVirology CY JUN 02-06, 2015 CL San Diego, CA C1 [Ndhlovu, Lishomwa C.; D'Antoni, Michelle L.; Byron, Mary Margaret; Ho, Erika; Agsalda-Garcia, Melissa; Shiramizu, Bruce; Shikuma, Cecilia M.] Univ Hawaii, John A Burns Sch Med, Hawaii Ctr AIDS, Honolulu, HI 96822 USA. [Ndhlovu, Lishomwa C.; D'Antoni, Michelle L.; Byron, Mary Margaret; Chalermchai, Thep; Tipsuk, Somporn; Agsalda-Garcia, Melissa; Shiramizu, Bruce] Univ Hawaii, John A Burns Sch Med, Dept Trop Med Med Microbiol & Pharmacol, Honolulu, HI 96822 USA. [Ananworanich, Jintanat] Walter Reed Army Inst Res, US Mil HIV Res Program, SEARCH, Bangkok, Thailand. [Ananworanich, Jintanat; Slike, Bonnie M.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Sithinamsuwan, Pasiri] Thai Red Cross AIDS Res Ctr, Bangkok, Thailand. [Slike, Bonnie M.; Schuetz, Alexandra] Walter Reed Army Inst Res, US Mil HIV Res Program, Bangkok, Thailand. [Schuetz, Alexandra] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Zhang, Guangxiang] Univ Hawaii, John A Burns Sch Med, Biostat & Data Management Core, Honolulu, HI 96822 USA. [Valcour, Victor Valcour] Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA USA. EM dantonim@hawaii.edu NR 0 TC 0 Z9 0 U1 1 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1355-0284 EI 1538-2443 J9 J NEUROVIROL JI J. Neurovirol. PD JUN PY 2015 VL 21 SU 1 MA P111 BP S51 EP S52 PG 2 WC Neurosciences; Virology SC Neurosciences & Neurology; Virology GA DA5ET UT WOS:000367826400112 ER PT J AU Singamaneni, SR Narayan, J Prater, JT AF Singamaneni, Srinivasa Rao Narayan, Jay Prater, John T. TI Multifunctional heterostructures integrated on Si (100) SO EMERGING MATERIALS RESEARCH LA English DT Review DE magnetic materials; oxides; thin films ID BATIO3 THIN-FILMS; X-RAY-DIFFRACTION; EPITAXIAL-GROWTH; EXCHANGE BIAS; NI FILMS; MISFIT DISLOCATIONS; DIELECTRIC-PROPERTIES; VAPOR-DEPOSITION; STRAIN RELIEF; SILICON AB Complex oxide films and heterostructures exhibit a wide range of functional properties, including colossal magnetoresistance, magnetocaloric effects, coupled magnetic and polarisation (multiferroic) behaviour, and some interesting physical phenomena including spin, charge and orbital ordering. However, putting this functionality to work remains a challenge. To date, most of the work reported in the literature has dealt with heterostructures deposited on closely lattice-matched insulating substrates such as DyScO3 (DSO), NdGaO3 (NGO), MgO and SrTiO3 (STO). Unfortunately, these substrates are incompatible with existing complementary metal oxide semiconductor (CMOS)-based technology, where silicon (Si) (100) substrates dominate. This review covers the major advances in the integration of multifunctional (oxide and non-oxide) materials onto Si (100) substrates reported in the recent past by the authors' group using pulsed laser deposition in conjunction with a novel layer growth approach called domain-matching epitaxy' (DME). This paper focuses on the growth of several important oxide systems, including BiFeO3 (BFO), La0.7Sr0.3MnO3 (LSMO), BaTiO3 (BTO), and non-oxide films including permalloy/MgO and Ni/MgO. It is shown that one can achieve thin-film epitaxy over an extended misfit scale by using the paradigm of DME. This will be critical for the future integration of multifunctional heterostructures onto CMOS-based chips in order to create smart structures for the next-generation solid-state devices. In addition, this paper explores the utility of using laser processing to introduce defect populations that induce magnetism in non-magnetic oxides such as STO and BTO as an alternative to incorporating more traditional magnetic layers into the structure. C1 [Singamaneni, Srinivasa Rao; Narayan, Jay; Prater, John T.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Singamaneni, Srinivasa Rao] Army Res Off, Div Mat Sci, Res Triangle Pk, NC USA. RP Singamaneni, SR (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Box 7907, Raleigh, NC 27695 USA. EM ssingam@ncsu.edu FU National Academy of Science (NAS), USA; Army Research Office [W911NF-04-D-0003]; State of North Carolina; National Science Foundation FX Srinivasa Rao Singamaneni acknowledges National Academy of Science (NAS), USA, for awarding the National Research Council (NRC) postdoctoral research associate fellowship. The authors acknowledge the support of the Army Research Office under Grant W911NF-04-D-0003. Also, the authors acknowledge the use of the Analytical Instrumentation Facility (AIF) at North Carolina State University, which is supported by the State of North Carolina and the National Science Foundation. NR 78 TC 3 Z9 3 U1 7 U2 35 PU ICE PUBLISHING PI WESTMINISTER PA INST CIVIL ENGINEERS, 1 GREAT GEORGE ST, WESTMINISTER SW 1P 3AA, ENGLAND SN 2046-0147 EI 2046-0155 J9 EMERG MATER RES JI Emerg. Mater. Res. PD JUN PY 2015 VL 4 IS 1 BP 50 EP 70 DI 10.1680/emr.14.00030 PG 21 WC Materials Science, Multidisciplinary SC Materials Science GA CX5CS UT WOS:000365719700007 ER PT J AU Goss, DL Lewek, M Yu, B Ware, WB Teyhen, DS Gross, MT AF Goss, Donald L. Lewek, Michael Yu, Bing Ware, William B. Teyhen, Deydre S. Gross, Michael T. TI Lower Extremity Biomechanics and Self-Reported Foot-Strike Patterns Among Runners in Traditional and Minimalist Shoes SO JOURNAL OF ATHLETIC TRAINING LA English DT Article DE barefoot running; ground reaction forces; negative work; loading rate ID GROUND REACTION FORCE; TIBIAL STRESS-FRACTURES; GENDER-DIFFERENCES; DISTANCE RUNNERS; FEMALE RUNNERS; RUNNING INJURIES; BAREFOOT; KINEMATICS; KNEE; ELECTROMYOGRAPHY AB Context: The injury incidence rate among runners is approximately 50%. Some individuals have advocated using an anterior-foot-strike pattern to reduce ground reaction forces and injury rates that they attribute to a rear-foot-strike pattern. The proportion of minimalist shoe wearers who adopt an anterior-foot-strike pattern remains unclear. Objective: To evaluate the accuracy of self-reported foot-strike patterns, compare negative ankle-and knee-joint angular work among runners using different foot-strike patterns and wearing traditional or minimalist shoes, and describe average vertical-loading rates. Design: Descriptive laboratory study. Setting: Research laboratory. Patients or Other Participants: A total of 60 healthy volunteers (37 men, 23 women; age = 34.9 +/- 8.9 years, height = 1.74 +/- 0.08 m, mass = 70.9 +/- 13.4 kg) with more than 6 months of experience wearing traditional or minimalist shoes were instructed to classify their foot-strike patterns. Intervention(s): Participants ran in their preferred shoes on an instrumented treadmill with 3-dimensional motion capture. Main Outcome Measure(s): Self-reported foot-strike patterns were compared with 2-dimensional video assessments. Runners were classified into 3 groups based on video assessment: traditional-shoe rear-foot strikers (TSR; n = 22), minimalist-shoe anterior-foot strikers (MSA; n = 21), and minimalist-shoe rear-foot strikers (MSR; n = 17). Ankle and knee negative angular work and average vertical-loading rates during stance phase were compared among groups. Results: Only 41 (68.3%) runners reported foot-strike patterns that agreed with the video assessment (kappa = 0.42, P < .001). The TSR runners demonstrated greater ankle-dorsiflexion and knee-extension negative work than MSA and MSR runners (P < .05). The MSA (P < .001) and MSR (P = .01) runners demonstrated greater ankle plantar-flexion negative work than TSR runners. The MSR runners demonstrated a greater average vertical-loading rate than MSA and TSR runners (P < .001). Conclusions: Runners often cannot report their foot-strike patterns accurately and may not automatically adopt an anterior-foot-strike pattern after transitioning to minimalist running shoes. C1 [Goss, Donald L.] Keller Army Community Hosp, US Mil Baylor Univ Sports Med Doctoral Program, West Point, NY 10996 USA. [Lewek, Michael; Yu, Bing; Ware, William B.; Gross, Michael T.] Univ N Carolina, Chapel Hill, NC USA. [Teyhen, Deydre S.] Def Hlth Headquarters, Syst Hlth & Performance Triad, Falls Church, VA USA. RP Goss, DL (reprint author), Keller Army Community Hosp, US Mil Baylor Univ Sports Med Doctoral Program, Bldg 900 Washington Rd, West Point, NY 10996 USA. EM Donald_Goss@baylor.edu NR 50 TC 4 Z9 4 U1 3 U2 12 PU NATL ATHLETIC TRAINERS ASSOC INC PI DALLAS PA 2952 STEMMONS FREEWAY, DALLAS, TX 75247 USA SN 1062-6050 EI 1938-162X J9 J ATHL TRAINING JI J. Athl. Train. PD JUN PY 2015 VL 50 IS 6 BP 603 EP 611 DI 10.4085/1062-6050.49.6.06 PG 9 WC Sport Sciences SC Sport Sciences GA CW7MK UT WOS:000365183100006 PM 26098391 ER PT J AU Rutvisuttinunt, W Schaecher, KE Noedl, H Lon, CT Tyner, S Lanteri, CA Jongsakul, K Bethell, D Smith, BL Saunders, DL Fukuda, MM AF Rutvisuttinunt, Wiriya Schaecher, Kurt E. Noedl, Harald Lon, Chan Thap Tyner, Stuart Lanteri, Charlotte A. Jongsakul, Krisada Bethell, Delia Smith, Bryan L. Saunders, David L. Fukuda, Mark M. TI Sequence analysis of Plasmodium falciparum SERCA-type pfATPase6 in field isolates collected along Thai-Cambodian border SO ASIAN BIOMEDICINE LA English DT Article DE PfATPase6; pfATP6; plasmodium falciparum; SERCA ID ANTIMALARIAL-DRUG ARTEMISININ; GENE COPY NUMBER; PFMDR 1 GENE; UNCOMPLICATED MALARIA; MULTIDRUG-RESISTANCE; CLINICAL-RESPONSE; WESTERN CAMBODIA; POINT MUTATIONS; CANDIDATE GENES; SOUTHEAST-ASIA AB Background: Polymorphisms in the P. falciparum gene for ATPase6 (pfATPase6) have been proposed as markers for artemisinin resistance, though the precise artemisinin binding pocket has not yet been comprehensively investigated in cases of treatment failure from along the Thai-Cambodian border. Objective: To investigate the specific regions of pfATPase6 in adequate clinical and parasitological response and treatment failures from Thai-Cambodian border. Methods: We examined polymorphisms in pfATPase6 by sequence analysis in parasites collected from 164 patients with uncomplicated malaria showing variable clinical phenotypes (13 cases of treatment failure and 151 adequate clinical and parasitological response) from adjacent areas on either side of the Thai-Cambodian border during the period 2005-2007. We investigated potential correlations between putative binding pocket polymorphisms with clinical response. Results: The majority of DNA sequences coding for the proposed artesunate binding pocket (M3, M5, and M7 helices) and the regions around Ser769 were conserved in parasite populations collected from patients in both study sites, regardless of clinical outcome. Conclusions: The previously proposed areas of pfATPase6 did not appear to vary based on clinical outcome in a large number of patients from Southeast Asia, suggesting these regions are unlikely to be useful as molecular markers of resistance in clinical specimens from the Southeast Asian region. C1 [Rutvisuttinunt, Wiriya; Schaecher, Kurt E.; Tyner, Stuart; Lanteri, Charlotte A.; Jongsakul, Krisada; Bethell, Delia; Smith, Bryan L.; Saunders, David L.; Fukuda, Mark M.] Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand. [Noedl, Harald] Med Univ Vienna, Vienna, Austria. [Lon, Chan Thap] Armed Forces Res Inst Med Sci, Dept Immunol & Med, Phnom Penh, Cambodia. RP Rutvisuttinunt, W (reprint author), Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand. EM Wiriyar@afrims.org FU Global Emerging Infections Surveillance and Response System FX We thank CNM, staff, Director and staff of hospitals at Tasanh, Cambodia, and Trat, Thailand. We thank Dr. Suwanna Chaorattanakawee, Ms. Nitima Chanarat, Ms. Sabaithip Sriwichai, Ms. Mali Ittiverakul and other staff at Molecular and Culture-In vitro laboratory at Department of Immunology and Medicine, AFRIMS, and Dr. Piyawan Chinnawirotpisan and Dr. Chonticha Klungthong from the Molecular Section, Department of Virology for their assistance in laboratory procedures, program analysis, and clinical documents. All authors thank the Global Emerging Infections Surveillance and Response System for financial support of this work. We are grateful to the patients who participated in this study and hope that the knowledge gained will contribute to a continuing decrease of severe malaria in Cambodia. NR 43 TC 0 Z9 0 U1 0 U2 0 PU CHULALONGKORN UNIV, FAC MED PI BANGKOK PA CHULALONGKORN UNIV, FAC MED, 1873, RAMA 4, BANGKOK, 10330, THAILAND SN 1905-7415 EI 1875-855X J9 ASIAN BIOMED JI Asian Biomed. PD JUN PY 2015 VL 9 IS 3 BP 343 EP 351 DI 10.5372/1905-7415.0903.403 PG 9 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA CV8EA UT WOS:000364510900010 ER PT J AU Akekawatchai, C Sretapunya, W Pipatsatitpong, D Chuenchit, T AF Akekawatchai, Chareeporn Sretapunya, Warisara Pipatsatitpong, Duangnate Chuenchit, Tippawan TI Hepatitis B or C virus coinfection in and risks for transaminitis in human immunodeficiency virus - infected Thais on combined antiretroviral therapy SO ASIAN BIOMEDICINE LA English DT Article DE Coinfection; combination antiretroviral therapy; hepatitis B virus; hepatitis C virus; hepatotoxicity; human immunodeficiency virus; transaminitis ID HEPATOCELLULAR-CARCINOMA; HIV-1-INFECTED ADULTS; VIRAL-HEPATITIS; LIVER-DISEASE; HIV-INFECTION; THAILAND; HEPATOTOXICITY; HAART; METAANALYSIS; INDIVIDUALS AB Background: The impact of hepatitis B or C virus (HBV or HCV) coinfection on the progression of liver diseases in patients infected with human immunodeficiency virus (HIV) on highly active antiretroviral therapy (HAART) has not been fully studied in resource-limited settings. Objectives: To examine the seroprevalence of HBV or HCV coinfection and its effect on hepatic function in HIV-infected Thai patients receiving HAART. Methods: A single-center cross-sectional study was conducted from October 2011 to January 2013 in Thai patients infected with HIV (n = 211). Combination ART was received by 94.3% of the patients (median duration, 32.1 (range, 0-95.3) months). The patients were screened for HBV and HCV infection and examined for transaminitis, defined as levels of aspartate aminotransferases (AST) and/or alanine aminotransferase (ALT) increased above the upper normal limits, and ARV-associated hepatotoxicity. Regression analyses were performed to determine risks for transaminitis in the studied group. Results: Prevalence of HBV or HCV coinfection in the HIV-infected patients was 11.4% and 7.6%, respectively and the rate of transaminitis was 26.5%, with only one patient developing severe grade 3 hepatotoxicity. Univariate and multivariate analyses indicated that predictive risk factors for transaminitis in this study group were seropositivity for HCV (OR 12.3, 95% CI 3.0-50.1, P < 0.001), but not for HBV, together with age difference, sex, and CD4(+) cell count. Conclusions: Coinfection with HCV is a potentially more important risk for transaminitis than coinfection with HBV, leading to chronic liver diseases in HIV-infected Thai patients with ongoing HAART. C1 [Akekawatchai, Chareeporn; Pipatsatitpong, Duangnate] Thammasat Univ, Fac Allied Hlth Sci, Dept Med Technol, Pathum Thani 12121, Thailand. [Sretapunya, Warisara] Thammasat Univ, Fac Allied Hlth Sci, Grad Program Med Technol, Pathum Thani 12121, Thailand. [Chuenchit, Tippawan] Armed Forces Res Inst Med Sci, Res Div, Bangkok 10400, Thailand. RP Akekawatchai, C (reprint author), Thammasat Univ, Fac Allied Hlth Sci, Dept Med Technol, Pathum Thani 12121, Thailand. EM ejareepo@tu.ac.th FU Thammasat University, Thailand FX Special thanks are due to the patients who voluntarily participated in this study and Pattarakan Thongkhonburi, M.D., Nakhon Nayok hospital, for her advice. The authors also thank Professor Pramuan Tepchaisri, Thammasat University, for reviewing the manuscript. This study was financially supported by the 2013-2014 fiscal year budget of Thammasat University, Thailand. NR 35 TC 1 Z9 1 U1 1 U2 3 PU CHULALONGKORN UNIV, FAC MED PI BANGKOK PA CHULALONGKORN UNIV, FAC MED, 1873, RAMA 4, BANGKOK, 10330, THAILAND SN 1905-7415 EI 1875-855X J9 ASIAN BIOMED JI Asian Biomed. PD JUN PY 2015 VL 9 IS 3 BP 353 EP 361 DI 10.5372/1905-7415.0903.404 PG 9 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA CV8EA UT WOS:000364510900011 ER PT J AU Glaz, B Riddick, J Habtour, E Kang, H AF Glaz, Bryan Riddick, Jaret Habtour, Ed Kang, Hao TI Interfacial Strain Energy Dissipation in Hybrid Nanocomposite Beams Under Axial Strain Fields SO AIAA JOURNAL LA English DT Article ID ROTARY-WING AEROELASTICITY; CARBON NANOTUBE COMPOSITES; POLYMER MATRIX COMPOSITES; DAMPING CHARACTERISTICS; FRICTION; ROTOR; LOADS; SLIP AB A micromechanics and structural dynamics analysis of inherent damping exhibited by representative hybrid nanocomposite beams under axial strains is presented. The approximate model is used to assess the potential aeroelastic/aeromechanical stability enhancement of helicopter rotor blades from carbon nanotube matrix inclusions. The matrix/nanoinclusion micromechanics before the occurrence of interfacial slip are based on the Cox model for discontinuous fiber reinforcement, and the frictional energy dissipation is assumed to be proportional to the interfacial shear force where slip has occurred. The validity of the model is established by comparing with experimental measurements of storage and loss moduli for a polymer nanocomposite. The relatively simple model captures the salient features of nanocomposite interfacial slip energy dissipation once uncertainties in fiber orientation and dispersion are accounted for in an approximate manner by using an effective volume fraction. The validated model is then used to calculate damping of the first in-plane bending mode when a beam is subjected to axial strain fields representative of hingeless rotor blades. Results indicate that hybrid nanocomposites with nanoinclusions show significant potential for contributing to future vertical lift capabilities by augmenting rotorcraft aeromechanical stability margins of hingeless/bearingless rotors. C1 [Glaz, Bryan; Riddick, Jaret; Habtour, Ed; Kang, Hao] US Army, Res Lab, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Glaz, B (reprint author), US Army, Res Lab, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA. OI Habtour, Ed/0000-0002-9083-9285 NR 26 TC 2 Z9 2 U1 2 U2 5 PU AMER INST AERONAUTICS ASTRONAUTICS PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0001-1452 EI 1533-385X J9 AIAA J JI AIAA J. PD JUN PY 2015 VL 53 IS 6 BP 1544 EP 1554 DI 10.2514/1.J053390 PG 11 WC Engineering, Aerospace SC Engineering GA CH9WD UT WOS:000354386200012 ER PT J AU Choi, JH Kim, YH Novak, J Mendoza, D Morris, R Burke, T Edsall, PR Akers, A Johnson, AJ Lund, BJ AF Choi, Jae Hyek Kim, Yu H. Novak, Joseph Mendoza, Danilo Morris, Ryan Burke, Teresa Edsall, Peter R. Akers, Andre Johnson, Anthony J. Lund, Brain J. TI Intravitereal Pressure (IVP) During Primary Blast Exposure in an in-situ Porcine Cadaver Model SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract CT Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO) CY MAY 03-07, 2015 CL Denver, CO SP Assoc Res Vis & Ophthalmol C1 [Choi, Jae Hyek; Mendoza, Danilo; Morris, Ryan; Burke, Teresa; Edsall, Peter R.; Akers, Andre; Johnson, Anthony J.; Lund, Brain J.] US Army, Inst Surg Rearch, Ocular Trauma Task Area, San Antonio, TX USA. [Kim, Yu H.] US Army, Brook Army Med Ctr, Dept Surg, Jbsa Ft Sam Houston, TX USA. [Novak, Joseph] US Army, Inst Surg Res, Dept Pathol, Jbsa Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC PI ROCKVILLE PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA SN 0146-0404 EI 1552-5783 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD JUN PY 2015 VL 56 IS 7 MA 6024 PG 2 WC Ophthalmology SC Ophthalmology GA CT5ZY UT WOS:000362891107093 ER PT J AU Cornell, LE Desilva, M Johnson, AJ Zamora, DO AF Cornell, Lauren Elsworth Desilva, Mauris Johnson, Anthony J. Zamora, David O. TI Potential therapeutic use of nanoparticle-loaded cells to repair damaged corneal endothelium SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract CT Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO) CY MAY 03-07, 2015 CL Denver, CO SP Assoc Res Vis & Ophthalmol C1 [Cornell, Lauren Elsworth; Johnson, Anthony J.; Zamora, David O.] US Army Inst Surg Res, Ocular Trauma & Vis Restorat, Ft Sam Houston, TX USA. [Desilva, Mauris] Naval Med Res Unit San Antonio JBSA, Maxillofacial Injury & Dis Dept, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC PI ROCKVILLE PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA SN 0146-0404 EI 1552-5783 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD JUN PY 2015 VL 56 IS 7 MA 5037 PG 2 WC Ophthalmology SC Ophthalmology GA CT5ZY UT WOS:000362891104394 ER PT J AU Glickman, RD Gray, W Lund, B Sponsel, WE Sherwood, D Reilly, MA AF Glickman, Randolph D. Gray, Walter Lund, Brian Sponsel, William Eric Sherwood, Daniel Reilly, Matthew Aaron CA Sub-Lethal Ocular Trauma TI Risk of Injury to Ocular Tissues from Primary Blast Overpressure Exposure SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract CT Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO) CY MAY 03-07, 2015 CL Denver, CO SP Assoc Res Vis & Ophthalmol C1 [Glickman, Randolph D.] Univ Texas Hlth Sci Ctr SA, Dept Ophthalmol, San Antonio, TX USA. [Glickman, Randolph D.; Sponsel, William Eric; Sherwood, Daniel; Reilly, Matthew Aaron] Univ Texas San Antonio, Biomed Engn, San Antonio, TX USA. [Gray, Walter] Univ Texas San Antonio, Geosci, San Antonio, TX USA. [Lund, Brian] US Army, Inst Surg Res, Ocular Trauma, Joint Base San Antonio, TX USA. [Sponsel, William Eric] WESMD Profess Associates, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 3 U2 3 PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC PI ROCKVILLE PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA SN 0146-0404 EI 1552-5783 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD JUN PY 2015 VL 56 IS 7 MA 6029 PG 2 WC Ophthalmology SC Ophthalmology GA CT5ZY UT WOS:000362891107098 ER PT J AU Hernandez, J Reilly, MA Gray, W Lund, B Sponsel, WE Glickman, RD AF Hernandez, Jessica Reilly, Matthew Aaron Gray, Walter Lund, Brian Sponsel, William Eric Glickman, Randolph D. CA Sub-lethal Ocular Trauma TI Ocular Trauma-Induced Changes in Aqueous and Plasma Biomarker Expression Levels SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract CT Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO) CY MAY 03-07, 2015 CL Denver, CO SP Assoc Res Vis & Ophthalmol C1 [Hernandez, Jessica; Reilly, Matthew Aaron; Sponsel, William Eric; Glickman, Randolph D.] UTSA, Biomed Engn, San Antonio, TX USA. [Gray, Walter] UTSA, Geosci, San Antonio, TX USA. [Lund, Brian] US Army, Inst Surg Res, JBSA Ft Sam Houston, San Antonio, TX USA. [Sponsel, William Eric] Incarnate Word, Optometry, San Antonio, TX USA. [Glickman, Randolph D.] UTHSCSA, Ophthalmol, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC PI ROCKVILLE PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA SN 0146-0404 EI 1552-5783 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD JUN PY 2015 VL 56 IS 7 MA 6026 PG 3 WC Ophthalmology SC Ophthalmology GA CT5ZY UT WOS:000362891107095 ER PT J AU Jones, K Hyek-Choi, J Sponsel, WE Gray, W Groth, SL Glickman, RD Reilly, MA Lund, B AF Jones, Kirstin Hyek-Choi, Jae Sponsel, William Eric Gray, Walter Groth, Sylvia Linner Glickman, Randolph D. Reilly, Matthew Aaron Lund, Brian TI Effects of in vivo Isolated Low-level Primary Blast Overpressure in Dutch Belted Rabbit: Corneal and Retinal Tomographic Responses SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract CT Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO) CY MAY 03-07, 2015 CL Denver, CO SP Assoc Res Vis & Ophthalmol C1 [Jones, Kirstin; Sponsel, William Eric; Reilly, Matthew Aaron] UTSA, Biomed Engn, Fair Oaks Ranch, TX USA. [Hyek-Choi, Jae; Lund, Brian] US Army, Inst Surg Res, JBSA Ft Sam Houston, San Antonio, TX USA. [Sponsel, William Eric] Univ Incarnate Word, Rosenberg Sch Optometry, San Antonio, TX USA. [Gray, Walter] Univ Texas San Antonio, Dept Geol Sci, San Antonio, TX USA. [Groth, Sylvia Linner] Univ N Carolina, Dept Ophthalmol, Chapel Hill, NC USA. [Glickman, Randolph D.] Univ Texas Hlth Sci Ctr San Antonio, Dept Ophthalmol, San Antonio, TX 78229 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC PI ROCKVILLE PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA SN 0146-0404 EI 1552-5783 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD JUN PY 2015 VL 56 IS 7 MA 6025 PG 2 WC Ophthalmology SC Ophthalmology GA CT5ZY UT WOS:000362891107094 ER PT J AU Kaini, RR Golden, D Bukre, TA Wang, HCH AF Kaini, Ramesh Raj Golden, Dallas Bukre, Teresa A. Wang, Heuy-Ching Hetty TI Extracellular matrix remodeling during 3D retinal differentiation of human induced pluripotent stem cells SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract CT Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO) CY MAY 03-07, 2015 CL Denver, CO SP Assoc Res Vis & Ophthalmol C1 [Kaini, Ramesh Raj; Golden, Dallas; Bukre, Teresa A.; Wang, Heuy-Ching Hetty] US Army, Inst Surg Rsrch, Ocular Trauma, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC PI ROCKVILLE PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA SN 0146-0404 EI 1552-5783 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD JUN PY 2015 VL 56 IS 7 MA 3600 PG 2 WC Ophthalmology SC Ophthalmology GA CT5ZY UT WOS:000362891101225 ER PT J AU Lund, B Choi, JH Novak, J Mendoza, D Bukre, TA Edsall, PR Akers, A Cleland, JM Johnson, AJ Wang, HCH AF Lund, Brian Choi, Jae Hyek Novak, Joseph Mendoza, Danilo Bukre, Teresa A. Edsall, Peter R. Akers, Andre Cleland, Jeffery M. Johnson, Anthony J. Wang, Heuy-Ching Hetty TI Cumulative Effects of Repeated Low-Level Blast on the Optic Nerve in a Rat Model SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract CT Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO) CY MAY 03-07, 2015 CL Denver, CO SP Assoc Res Vis & Ophthalmol C1 [Lund, Brian; Choi, Jae Hyek; Mendoza, Danilo; Bukre, Teresa A.; Edsall, Peter R.; Akers, Andre; Cleland, Jeffery M.; Johnson, Anthony J.; Wang, Heuy-Ching Hetty] US Army, Inst Surg Res, Ocular Trauma, Jbsa Ft Sam Houston, TX USA. [Novak, Joseph] US Army, Inst Surg Res, Pathol, Jbsa Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC PI ROCKVILLE PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA SN 0146-0404 EI 1552-5783 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD JUN PY 2015 VL 56 IS 7 MA 6051 PG 2 WC Ophthalmology SC Ophthalmology GA CT5ZY UT WOS:000362891107120 ER PT J AU Watson, R Gray, W Sponsel, WE Lund, B Glickman, RD Groth, SL Reilly, MA AF Watson, Richard Gray, Walter Sponsel, William Eric Lund, Brian Glickman, Randolph D. Groth, Sylvia Linner Reilly, Matthew Aaron TI Simulations of Porcine Eye Exposure to Primary Blast Insult SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract CT Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO) CY MAY 03-07, 2015 CL Denver, CO SP Assoc Res Vis & Ophthalmol C1 [Watson, Richard; Gray, Walter; Sponsel, William Eric; Reilly, Matthew Aaron] UTSA, Biomed Engn, Helotes, TX USA. [Lund, Brian] US Army, Inst Surg Res, San Antonio, TX USA. [Glickman, Randolph D.] Univ Texas Hlth Sci Ctr San Antonio, Dept Opthalmol, San Antonio, TX 78229 USA. [Groth, Sylvia Linner] Univ N Carolina, Sch Med, Dept Opthalmol, Chapel Hill, NC USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC PI ROCKVILLE PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA SN 0146-0404 EI 1552-5783 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD JUN PY 2015 VL 56 IS 7 MA 6030 PG 2 WC Ophthalmology SC Ophthalmology GA CT5ZY UT WOS:000362891107099 ER PT J AU Wehmeyer, JL Johnson, AJ Zamora, D AF Wehmeyer, Jennifer L. Johnson, Anthony J. Zamora, David TI Development of a lyophilized amniotic membrane allograft for the treatment of ophthalmic injury SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract CT Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO) CY MAY 03-07, 2015 CL Denver, CO SP Assoc Res Vis & Ophthalmol C1 [Wehmeyer, Jennifer L.; Johnson, Anthony J.; Zamora, David] US Army Inst Surg Res, Ocular Trauma & Vis Restorat Program, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC PI ROCKVILLE PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA SN 0146-0404 EI 1552-5783 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD JUN PY 2015 VL 56 IS 7 MA 3480 PG 2 WC Ophthalmology SC Ophthalmology GA CT5ZY UT WOS:000362891101119 ER PT J AU Greene, W AF Greene, Whitney TI The development of an in vitro model of proliferative vitreoretinopathy using retinal pigment epithelium derived from induced pluripotent stem cells SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract CT Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO) CY MAY 03-07, 2015 CL Denver, CO SP Assoc Res Vis & Ophthalmol C1 [Greene, Whitney] US Army Inst Surg Res, Ocular Trauma, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC PI ROCKVILLE PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA SN 0146-0404 EI 1552-5783 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD JUN PY 2015 VL 56 IS 7 MA 1274 PG 2 WC Ophthalmology SC Ophthalmology GA CT5WQ UT WOS:000362882203176 ER PT J AU Griffith, GL Wirostko, BM Lee, HK Zamora, DO Johnson, AJ AF Griffith, Gina L. Wirostko, Barbara M. Lee, Hee-Kyoung Zamora, David O. Johnson, Anthony James TI Model development: Use of a biocompatible thiolated hyaluronic acid biomaterial for the treatment of corneal epithelial wounds SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract CT Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO) CY MAY 03-07, 2015 CL Denver, CO SP Assoc Res Vis & Ophthalmol C1 [Griffith, Gina L.; Zamora, David O.; Johnson, Anthony James] US Army Inst Surg Res, Ocular Trauma, Ft Sam Houston, TX USA. [Wirostko, Barbara M.; Lee, Hee-Kyoung] Univ Utah, Moran Eye Ctr, Salt Lake City, UT USA. [Wirostko, Barbara M.; Lee, Hee-Kyoung] Jade Therapeut Inc, Salt Lake City, UT USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC PI ROCKVILLE PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA SN 0146-0404 EI 1552-5783 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD JUN PY 2015 VL 56 IS 7 MA 3089 PG 2 WC Ophthalmology SC Ophthalmology GA CT5WQ UT WOS:000362882207252 ER PT J AU Packer, K Chen, S Andreo, L Lowry, J Zumbrun, S AF Packer, Kyle Chen, Sien Andreo, Larry Lowry, Jake Zumbrun, Steve TI Novel Anterior Chamber Tube Shunt with Tissue Autograft SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract CT Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO) CY MAY 03-07, 2015 CL Denver, CO SP Assoc Res Vis & Ophthalmol C1 [Packer, Kyle; Chen, Sien; Andreo, Larry; Lowry, Jake; Zumbrun, Steve] Eisenhower Army Med Ctr, Ft Gordon, GA USA. [Packer, Kyle] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC PI ROCKVILLE PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA SN 0146-0404 EI 1552-5783 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD JUN PY 2015 VL 56 IS 7 MA 2706 PG 2 WC Ophthalmology SC Ophthalmology GA CT5WQ UT WOS:000362882206275 ER PT J AU Wirostko, BM Griffith, GL Zamora, DO Rafii, M Johnson, AJ Lee, HK AF Wirostko, Barbara M. Griffith, Gina L. Zamora, David O. Rafii, MaryJane Johnson, Anthony James Lee, Hee-Kyoung TI Sustained Delivery of rHGH via a Novel, Biodegradable, Hyaluronic Acid (HA) Polymer Film SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract CT Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO) CY MAY 03-07, 2015 CL Denver, CO SP Assoc Res Vis & Ophthalmol C1 [Wirostko, Barbara M.; Rafii, MaryJane; Lee, Hee-Kyoung] Jade Therapeut, Salt Lake City, UT USA. [Wirostko, Barbara M.] Univ Utah, Moran Eye Ctr, Salt Lake City, UT USA. [Griffith, Gina L.; Zamora, David O.; Johnson, Anthony James] US Army Inst Surg Res, Ocular Trauma, Ft Sam Houston, TX USA. [Lee, Hee-Kyoung] Univ Utah, Salt Lake City, UT USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC PI ROCKVILLE PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA SN 0146-0404 EI 1552-5783 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD JUN PY 2015 VL 56 IS 7 MA 262 PG 3 WC Ophthalmology SC Ophthalmology GA CT5WQ UT WOS:000362882201021 ER PT J AU Zhu, H Johnson, AJ Lewis, A DeMartelaere, S Cho, R Kim, M Wang, HC Kochevar, IE AF Zhu, Hong Johnson, Anthony J. Lewis, Andrew DeMartelaere, Sheri Cho, Raymond Kim, Mirang Wang, Heuy-Ching Kochevar, Irene E. TI Comparison of Chemical and Photo-Crosslinked Amniotic Membrane with Cryopreserved Amniotic Membrane for the Treatment of Severe Exposure Keratopathy in the New Zealand White Rabbit SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract CT Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO) CY MAY 03-07, 2015 CL Denver, CO SP Assoc Res Vis & Ophthalmol C1 [Zhu, Hong; Kochevar, Irene E.] Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA. [Johnson, Anthony J.; Kim, Mirang; Wang, Heuy-Ching] US Army Inst Surg Res, Res, Ft Sam Houston, TX USA. [Lewis, Andrew; DeMartelaere, Sheri; Cho, Raymond] San Antonio Mil Med Ctr, Res, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC PI ROCKVILLE PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA SN 0146-0404 EI 1552-5783 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD JUN PY 2015 VL 56 IS 7 MA 735 PG 3 WC Ophthalmology SC Ophthalmology GA CT5WQ UT WOS:000362882202073 ER PT J AU Cui, Y Chang, WH Mahoney, E AF Cui, Yue Chang, Wen-Huei Mahoney, Ed TI ECONOMIC IMPACTS OF RECREATIONAL USE OF INLAND WATERWAYS IN US SO INTERNATIONAL JOURNAL OF TRANSPORT ECONOMICS LA English DT Article DE Economic impacts; recreation; navigation; performance ID TOURISM AB Recreational activities, such as boating, on inland waterways are becoming increasingly more popular at a time when public funding for developing and maintaining recreational facilities and services is generally being reduced. In the United States, federal budgetary funds are allocated based on performance outputs and national economic development benefits and clear priority is given to commercial harbours and navigation channels over recreational harbours. This has created significant difficulties particularly when it comes to dredging during this current period of extremely low water levels. Recreational boating advocates argue that boating is too economically important not to maintain and enhance these recreational harbours, and even more so because of the economic downturn in many regions. Considering these backgrounds, this study provides a review of different methods for estimating the economic impacts of water based recreation activities, including recreational boating, fishing and cruise ship, which are benefited from US Army Corps of Engineers' navigation projects. This paper in further demonstrates the proposed methods by a simulation tool, RECONS (Regional Economic System), developed for US Army Corps of Engineers. This study includes a review of various methods (e.g., surveys) for estimating spending (e.g., annual craft, trip spending) required for use in economic impact assessment models. It will also discuss the importance of and alternative ways to produce reliable estimates of boating use (e.g., boating trips), including several recent surveys designed and conducted by the authors. This study provides a comprehensive analysis of the recreational uses of Inland Waterways and develops economic impacts spending frameworks for different types of recreational activities. This was rarely done by previous studies. C1 [Cui, Yue; Mahoney, Ed] Michigan State Univ, E Lansing, MI 48824 USA. [Chang, Wen-Huei; Mahoney, Ed] US Army Corps Engineers, Inst Water Resources, Washington, DC USA. RP Cui, Y (reprint author), Michigan State Univ, E Lansing, MI 48824 USA. EM cuiyue@msu.edu NR 23 TC 1 Z9 1 U1 0 U2 3 PU IST EDITORIALI POLGRAFICI INT PI PISA PA CASELLA POSTALE N 1, SUCCURSALE N 8, 56123 PISA, ITALY SN 0391-8440 J9 INT J TRANSP ECON JI Int. J. Transp. Econ. PD JUN PY 2015 VL 42 IS 2 SI SI BP 171 EP 189 PG 19 WC Economics; Transportation SC Business & Economics; Transportation GA CS7AX UT WOS:000362237000003 ER PT J AU Simon, TE Daab, LJ White, PW White, JM Walker, PF Whittaker, DR Golarz, SR Craig, RM Brown, KA AF Simon, Todd E. Daab, Leo J. White, Paul W. White, Joseph M. Walker, Patrick F. Whittaker, David R. Golarz, Scott R. Craig, Robert M. Brown, Kevin A. TI A Quality Improvement Project to Improve IVC Filter Retrieval SO JOURNAL OF VASCULAR SURGERY LA English DT Meeting Abstract CT Vascular Annual Meeting CY 2015 CL Chicago, IL C1 [Simon, Todd E.; Daab, Leo J.; Walker, Patrick F.; Whittaker, David R.; Golarz, Scott R.; Brown, Kevin A.] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA. [White, Paul W.] Uniformed Serv Univ Hlth Sci, Walter Reed Natl Mil Med Ctr, Bethesda, MD 20814 USA. [Craig, Robert M.] US Army, Walter Reed Natl Mil Med Ctr, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0741-5214 J9 J VASC SURG JI J. Vasc. Surg. PD JUN PY 2015 VL 61 IS 6 SU S MA PC190 BP 169S EP 169S PG 1 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA CS2FS UT WOS:000361884200314 ER PT J AU Tracy, FT Oppe, TC Ward, WA Corcoran, MK AF Tracy, Fred T. Oppe, Thomas C. Ward, William A. Corcoran, Maureen K. TI A SCALABILITY STUDY USING SUPERCOMPUTERS FOR HUGE FINITE ELEMENT VARIABLY SATURATED FLOW SIMULATIONS SO SCALABLE COMPUTING-PRACTICE AND EXPERIENCE LA English DT Article DE high performance computing; finite element method; variably saturated seepage flow modeling AB This paper describes the challenges and scalability results of running a large finite element model of variably saturated flow in a three-dimensional (3-D) levee on a large high performance, parallel computer using a mesh with more than a billion nodes and two billion elements. MPI (Message Passing Interface) was used for the parallelization. The original finite element model consisted of 3,017,367 nodes and 5,836,072 3-D prism elements. The model exhibited three characteristics which made the problem difficult to solve. First, the different soil layers had soil properties that differed by several orders of magnitude. Secondly, there existed a 5 ft x 6 ft x 6 ft region at the toe of the levee where the mesh was refined using 1 in x 1 in x 1 in 3-D prism elements having randomly generated soil properties. Thirdly, variably saturated flow in levees is governed by the highly nonlinear Richards' equation. A utility program was written to increase the size of the original problem by an arbitrarily large factor by replicating the original mesh in the y direction. A factor of two, for instance, would exactly double the number of elements and double the number of nodes less the interface nodes connecting the two pieces. The original data set was run using 32, 64, 96, and 256 MPI processes (one core per process was used throughout this study) with time to solution taken for each of these process counts. The data set was then magnified by 2 and runs for 64, 128, 192, and 512 processes were made with time to solution again recorded. This procedure was repeated for different numbers of processes and magnification values. The largest data set was generated from a magnification of 350 yielding a mesh of 1,044,246,303 nodes and 2,042,625,200 3-D prism elements. The Cray XE6 and Cray XC30 computers were used in this study. A tabulation of results is presented and analyzed, as well as the significant challenges that occurred in scaling up the problem size. Weak and strong scalability results are also presented in this paper. C1 [Tracy, Fred T.] Engn Res & Dev Ctr ERDC, Informat Technol Lab ITL, Vicksburg, MS USA. [Oppe, Thomas C.] Erdc, ITL, Vicksburg, MS USA. [Ward, William A.] Erdc, ITL, HPCMP, Vicksburg, MS USA. [Corcoran, Maureen K.] Erdc, Geotech & Struct Lab, Vicksburg, MS USA. RP Tracy, FT (reprint author), Engn Res & Dev Ctr ERDC, Informat Technol Lab ITL, Vicksburg, MS USA. NR 16 TC 0 Z9 0 U1 0 U2 0 PU UNIV VEST TIMISOARA, WEST UNIV TIMISOARA PI TIMISOARA PA BLVD VASILE PARVAN 4, TIMISOARA, TIMIS 300223, ROMANIA SN 1895-1767 J9 SCALABLE COMPUT-PRAC JI Scalable Comput.-Pract. Exp. PD JUN PY 2015 VL 16 IS 2 SI SI BP 153 EP 168 PG 16 WC Computer Science, Software Engineering SC Computer Science GA CR6OG UT WOS:000361466300004 ER PT J AU Carlson, TA Welch, CR Kriven, WM Marsh, CP AF Carlson, Thomas A. Welch, Charles R. Kriven, Waltraud M. Marsh, Charles P. TI Effects of time, temperature, and pressure on the microstructure of spark plasma sintered silicon carbide SO JOURNAL OF CERAMIC PROCESSING RESEARCH LA English DT Article DE Silicon carbide; Spark plasma sintering; Densification; Microstructure ID MECHANICAL-PROPERTIES; SIC CERAMICS; DENSIFICATION; POWDER; SPS; TRANSFORMATION AB Silicon carbide is a ceramic material with useful properties that have many potential advanced applications. Achieving a range of desired properties is possible by carefully controlling the microstructure, which itself can be controlled by the spark plasma sintering conditions. We varied three sintering conditions and characterized the resulting microstructure. Our samples did not reach full density, and the densification and grain growth of nano-sized silicon carbide powder did not follow traditional trends. Instead, both features increased simultaneously. We conclude that additional experimentation is necessary to obtain fully dense samples and to characterize the microstructure of nanometer-sized silicon carbide powder affected by spark plasma sintering conditions. C1 [Carlson, Thomas A.; Marsh, Charles P.] US Army, Corps Engineers, Construct Engn Res Lab, Champaign, IL 61822 USA. [Welch, Charles R.] US Army, Corps Engineers, Informat Technol Lab, Vicksburg, MS 39180 USA. [Carlson, Thomas A.; Kriven, Waltraud M.] Univ Illinois, Dept Mat Sci & Engn, Urbana, IL 61820 USA. [Marsh, Charles P.] Univ Illinois, Dept Nucl Plasma & Radiol Engn, Urbana, IL 61820 USA. RP Carlson, TA (reprint author), US Army, Corps Engineers, Construct Engn Res Lab, Champaign, IL 61822 USA. EM tacarlso@illinois.edu FU U.S. Army Engineer Research and Development Center, Construction Engineering Research Laboratory, Champaign, IL under Section 219 Center Directed Research Program, "Nanoscale Studies of the Synthesis of Ceramic (Polycrystalline) Materials" FX This work was supported by the U.S. Army Engineer Research and Development Center, Construction Engineering Research Laboratory, Champaign, IL, under the Section 219 Center Directed Research Program, "Nanoscale Studies of the Synthesis of Ceramic (Polycrystalline) Materials." NR 15 TC 1 Z9 1 U1 0 U2 4 PU KOREAN ASSOC CRYSTAL GROWTH, INC PI SEOUL PA SUNGDONG POST OFFICE, P O BOX 27, SEOUL 133-600, SOUTH KOREA SN 1229-9162 J9 J CERAM PROCESS RES JI J. Ceram. Process. Res. PD JUN PY 2015 VL 16 IS 3 BP 303 EP 307 PG 5 WC Materials Science, Ceramics SC Materials Science GA CQ8BV UT WOS:000360832100005 ER PT J AU DeRosa, R Stackhouse, DA McMann, LP Sterbis, JR AF DeRosa, Raffaella Stackhouse, Danielle A. McMann, Leah P. Sterbis, Joseph R. TI Penile Squamous Cell Carcinoma After a Childhood Hypospadias Repair With Bladder Mucosa Graft SO UROLOGY LA English DT Article ID EMPHASIS AB Bladder mucosa grafts were historically used for hypospadias surgical repairs, when preputial or penile skin was unavailable and in cases of prior failed hypospadias repairs. We present a case of advanced penile squamous cell carcinoma diagnosed 22 years after a childhood hypospadias repair with a free bladder mucosa graft. Published by Elsevier Inc. C1 [DeRosa, Raffaella; Stackhouse, Danielle A.; McMann, Leah P.; Sterbis, Joseph R.] Tripler Army Med Ctr, Div Urol, Dept Surg, Honolulu, HI 98659 USA. RP DeRosa, R (reprint author), Tripler Army Med Ctr, Div Urol, Dept Surg, 1 Jarrett White Rd, Honolulu, HI 98659 USA. EM Raffaella.Derosa.mil@mail.mil NR 9 TC 0 Z9 0 U1 1 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0090-4295 EI 1527-9995 J9 UROLOGY JI Urology PD JUN PY 2015 VL 85 IS 6 BP 1471 EP 1473 DI 10.1016/j.urology.2015.02.021 PG 3 WC Urology & Nephrology SC Urology & Nephrology GA CP8QJ UT WOS:000360158900068 PM 25863837 ER PT J AU Ogden, FL Lai, WC Steinke, RC Zhu, JT Talbot, CA Wilson, JL AF Ogden, Fred L. Lai, Wencong Steinke, Robert C. Zhu, Jianting Talbot, Cary A. Wilson, John L. TI A new general 1-D vadose zone flow solution method SO WATER RESOURCES RESEARCH LA English DT Article ID PARTICLE-SIZE DISTRIBUTION; SHALLOW-WATER TABLE; RICHARDS EQUATION; UNSATURATED FLOW; PONDED CONDITIONS; SOIL-MOISTURE; INFILTRATION; MODEL; REDISTRIBUTION; RUNOFF AB We have developed an alternative to the one-dimensional partial differential equation (PDE) attributed to Richards (1931) that describes unsaturated porous media flow in homogeneous soil layers. Our solution is a set of three ordinary differential equations (ODEs) derived from unsaturated flux and mass conservation principles. We used a hodograph transformation, the Method of Lines, and a finite water-content discretization to produce ODEs that accurately simulate infiltration, falling slugs, and groundwater table dynamic effects on vadose zone fluxes. This formulation, which we refer to as finite water-content, simulates sharp fronts and is guaranteed to conserve mass using a finite-volume solution. Our ODE solution method is explicitly integrable, does not require iterations and therefore has no convergence limits and is computationally efficient. The method accepts boundary fluxes including arbitrary precipitation, bare soil evaporation, and evapotranspiration. The method can simulate heterogeneous soils using layers. Results are presented in terms of fluxes and water content profiles. Comparing our method against analytical solutions, laboratory data, and the Hydrus-1D solver, we find that predictive performance of our finite water-content ODE method is comparable to or in some cases exceeds that of the solution of Richards' equation, with or without a shallow water table. The presented ODE method is transformative in that it offers accuracy comparable to the Richards (1931) PDE numerical solution, without the numerical complexity, in a form that is robust, continuous, and suitable for use in large watershed and land-atmosphere simulation models, including regional-scale models of coupled climate and hydrology. C1 [Ogden, Fred L.; Lai, Wencong; Steinke, Robert C.; Zhu, Jianting] Univ Wyoming, Dept Civil & Architectural Engn, Laramie, WY 82071 USA. [Talbot, Cary A.] US Army Corps Engn, Coastal & Hydraul Lab, Engineer Res & Dev Ctr, Vicksburg, MS USA. [Wilson, John L.] New Mexico Inst Min & Technol, Dept Earth & Environm Sci, Socorro, NM USA. RP Ogden, FL (reprint author), Univ Wyoming, Dept Civil & Architectural Engn, Laramie, WY 82071 USA. EM fogden@uwyo.edu FU U.S. National Science Foundation, EPSCoR program [1135483] FX Contribution: Improvements to the Talbot and Ogden [2008] algorithm were collaboratively made by Fred Ogden, Wencong Lai, and Bob Steinke, with the addition of capillary relaxation, falling slugs, and groundwater table dynamic effects on the vadose zone. Fred Ogden performed the original derivation of the T-O equation presented herein. Bob Steinke added falling slugs to the simulation code using a linked-list methodology. Julian Zhu served as an internal reviewer. Cary Talbot participated in discussions and provided the improved finite water-content figures. John Wilson suggested that the improved T-O method might be closer to RE than we had originally supposed, improved, and verified the derivation. This work was funded by the U.S. National Science Foundation, EPSCoR program through cooperative agreement 1135483 Collaborative Research: CI-WATER, Cyberinfrastructure to Advance High Performance Water Resource Modeling. Dani Or was instrumental in discussing the physical aspects of water behavior in the vadose zone. Craig C. Douglas and Vitaly Zlotnik provided useful input on the computer science and mathematics of our solution. Nels Frazier discovered that capillary relaxation of infiltration or groundwater fronts is equivalent to a numerical sort. Glenn Warner reviewed an earlier draft of this paper. We acknowledge the constructive review comments of WRR editor Graham Sander, Philip Broadbridge, and one anonymous reviewer. Panama rainfall data were provided by NSF EAR-1360384 WSC-Category 2 Collaborative Research: Planning and Land Management in a Tropical Ecosystem: Complexities of Land-use and Hydrology Coupling in the Panama Canal Watershed, and the Smithsonian Tropical Research Institute. Data / model statement: The code and data used for the 8 month infiltration test is available from http://dx.doi.org/10.15786/M2WC70. A video of the 8 month infiltration simulation on loam soil, with infiltration using Panama rainfall and ET data using the finite water-content discretization is available on you tube: http://youtu.be/vYwixGnTgms NR 69 TC 5 Z9 5 U1 8 U2 31 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0043-1397 EI 1944-7973 J9 WATER RESOUR RES JI Water Resour. Res. PD JUN PY 2015 VL 51 IS 6 BP 4282 EP 4300 DI 10.1002/2015WR017126 PG 19 WC Environmental Sciences; Limnology; Water Resources SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA CN3CK UT WOS:000358301200022 ER PT J AU Dorney, JR Paugh, L Smith, AP Allen, T Cusack, MT Savage, R Hughes, EB Munoz, B AF Dorney, John R. Paugh, LeiLani Smith, Alexander P. (Sandy) Allen, Thomas (Brad) Cusack, Matthew T. Savage, Rick Hughes, Emily B. Munoz, Breda TI The North Carolina Wetland Assessment Method (NC WAM): Development of a Rapid Wetland Assessment Method and Use for Compensatory Mitigation SO ENVIRONMENTAL PRACTICE LA English DT Review AB The North Carolina Wetland Assessment Method (NC WAM) was developed from 2003 to 2007 by a team of federal and state agencies to rapidly assess the level of wetland function. NC WAM is a field method which is science-based, reproducible, rapid, and observational in nature used to determine the level of wetland function relative to reference for each of 16 North Carolina general wetland types. Three major functions (Hydrology, Water Quality, and Habitat) were recognized along with 10 sub-functions. Sub-functions and functions are evaluated using 22 field metrics on a field assessment form. Data are entered into a computer program to generate High, Medium, and Low ratings for each sub-function, function, and the overall assessment area based on an iterative Boolean logic process using 71 unique combinations. The method was field tested across the state at more than 280 sites of varying wetland quality. Examples are presented for the use of NC WAM for compensatory mitigation notably to calculate functional uplift from wetland enhancement. Calibration and verification analyses to date show that the results of the method are significantly correlated with long-term wetland monitoring data and NC WAM has been verified for one wetland type (headwater forest) using these data. C1 [Dorney, John R.] Moffatt & Nichol, Raleigh, NC 27609 USA. [Paugh, LeiLani] North Carolina Dept Transportat, Nat Environm Unit, Raleigh, NC USA. [Smith, Alexander P. (Sandy)] Axiom Environm Inc, Raleigh, NC USA. [Savage, Rick] North Carolina Dept Environm & Nat Resources, Div Water Resources, Raleigh, NC USA. [Allen, Thomas (Brad); Cusack, Matthew T.] Atkins, Raleigh, NC USA. [Hughes, Emily B.] US Army Corps Engineers, Wilmington, NC USA. [Munoz, Breda] RTI Int, Res Triangle Pk, NC USA. RP Dorney, JR (reprint author), Moffatt & Nichol, 1616 East Millbrook Rd,Suite 160, Raleigh, NC 27609 USA. EM jdorney@moffattnichol.com NR 23 TC 0 Z9 0 U1 1 U2 4 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND SN 1466-0466 EI 1466-0474 J9 ENVIRON PRAC JI Environ. Pract. PD JUN PY 2015 VL 17 IS 2 BP 145 EP 155 DI 10.1017/S1466046615000046 PG 11 WC Environmental Sciences SC Environmental Sciences & Ecology GA CN4CH UT WOS:000358376000006 ER PT J AU McGann, P Snesrud, E Ong, AC Appalla, L Koren, M Kwak, YI Waterman, PE Lesho, EP AF McGann, Patrick Snesrud, Erik Ong, Ana C. Appalla, Lakshmi Koren, Michael Kwak, Yoon I. Waterman, Paige E. Lesho, Emil P. TI War Wound Treatment Complications Due to Transfer of an IncN Plasmid Harboring bla(OXA-181) from Morganella morganii to CTX-M-27-Producing Sequence Type 131 Escherichia coli SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID D BETA-LACTAMASE; CARBA NP TEST; KLEBSIELLA-PNEUMONIAE; UNITED-STATES; ENTEROBACTERIACEAE; INFECTIONS; RESISTANCE; CARBAPENEMASES; IMPACT; IDENTIFICATION AB A 22-year-old male developed a recurrent sacral abscess associated with embedded shrapnel following a blast injury. Cultures grew extended-spectrum beta-lactamase (ESBL)-producing, carbapenem-susceptible Escherichia coli. Ertapenem was administered, but the infection recurred after each course of antibiotics. Initial surgical interventions were unsuccessful, and subsequent cultures yielded E. coli and Morganella morganii, both nonsusceptible to carbapenems. The isolates were Carba NP test negative, gave ambiguous results with the modified Hodge test, and amplified the bla(OXA48)-like gene by real-time PCR. All E. coli isolates were sequence type 131 (ST131), carried nine resistance genes (including bla(CTX-M-27)) on an IncF plasmid, and were identical by genome sequencing, except for 150 kb of plasmid DNA in carbapenem-nonsusceptible isolates only. Sixty kilobases of this was shared by M. morganii and represented an IncN plasmid harboring bla(OXA-181). In M. morganii, the gene was flanked by IS3000 and ISKpn19, but in all but one of the E. coli isolates containing bla(OXA-181), a second copy of ISKpn19 had inserted adjacent to IS3000. To the best of our knowledge, this is the first report of bla(OXA-181) in the virulent ST131 clonal group and carried by the promiscuous IncN family of plasmids. The tendency of M. morganii to have high MICs of imipenem, a bla(OXA-181) substrate profile that includes penicillins but not extended-spectrum cephalosporins, and weak carbapenemase activity almost resulted in the presence of bla(OXA-181) being overlooked. We highlight the importance of surveillance for carbapenem resistance in all species, even those with intrinsic resistances, and the value of advanced molecular techniques in detecting subtle genetic changes. C1 [McGann, Patrick; Snesrud, Erik; Ong, Ana C.; Appalla, Lakshmi; Kwak, Yoon I.; Waterman, Paige E.; Lesho, Emil P.] Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD 20910 USA. [Koren, Michael] Walter Reed Natl Mil Med Ctr, Infect Dis Serv, Bethesda, MD USA. RP McGann, P (reprint author), Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD 20910 USA. EM patrick.t.mcgann4.ctr@mail.mil FU U.S. Army Medical Command; Global Emerging Infections Surveillance and Response System; Defense Medical Research and Development Program FX This study was funded by the U.S. Army Medical Command, the Global Emerging Infections Surveillance and Response System, and the Defense Medical Research and Development Program. NR 42 TC 6 Z9 6 U1 1 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD JUN PY 2015 VL 59 IS 6 BP 3556 EP 3562 DI 10.1128/AAC.04442-14 PG 7 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA CN7OF UT WOS:000358623200073 PM 25870058 ER PT J AU Roberts, AT Medley, SK Gregory, DA Dhote, NB AF Roberts, Adam T. Medley, Stephanie K. Gregory, Don A. Dhote, Nilesh B. TI Simplified estimation of the eye's response to flashing light-emitting diodes SO JOURNAL OF BIOMEDICAL OPTICS LA English DT Article DE light-emitting diode; effective intensity; photopic measurements; eye response; pulsed light ID VISION AB A useful laboratory technique has been devised using commonly available optical hardware and software to accurately measure the eye's response to flashing light-emitting diode (LED) sources. A simplified version of the modified Allard technique is implemented using a silicon detector, a digital multimeter, and Labview (R) software to collect and analyze the data. Using calibrated radiometric measurements, the method presented allows quantifying, in photopic units, the human eye's response to these sources. The procedure first requires exact conversion of irradiance measurements from radiometric to photopic units and this is done; however, during the study, it was determined that for LEDs with narrow spectra, this conversion can be simplified using an approximation. This involves taking the spectral form of the LED to be a delta function situated at its peak wavelength, which makes the conversion from watts to lumens a simple multiplication by the luminous efficiency, eta(lambda) value at that peak wavelength. For LEDs with a full width at half maximum of 20 nm or less, this approximation is found to be accurate to +/- 5% throughout the visible range. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. C1 [Roberts, Adam T.; Medley, Stephanie K.; Gregory, Don A.] Univ Alabama, Dept Phys, Huntsville, AL 35899 USA. [Roberts, Adam T.] US Army, Weapon Sci Directorate, Aviat & Missile Res & Dev Command, Redstone Arsenal, AL 35898 USA. [Medley, Stephanie K.] Simulat Technol Inc, Huntsville, AL 35805 USA. [Dhote, Nilesh B.] K Sci, Huntsville, AL 35805 USA. RP Gregory, DA (reprint author), Univ Alabama, Dept Phys, Huntsville, AL 35899 USA. EM gregoryd@uah.edu NR 17 TC 0 Z9 0 U1 0 U2 5 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 1083-3668 EI 1560-2281 J9 J BIOMED OPT JI J. Biomed. Opt. PD JUN PY 2015 VL 20 IS 6 AR 065005 DI 10.1117/1.JBO.20.6.065005 PG 5 WC Biochemical Research Methods; Optics; Radiology, Nuclear Medicine & Medical Imaging SC Biochemistry & Molecular Biology; Optics; Radiology, Nuclear Medicine & Medical Imaging GA CN6AP UT WOS:000358516100016 PM 26091373 ER PT J AU Perez, C AF Perez, Celestino, Jr. TI War's Ends: Human Rights, International Order, and the Ethics of Peace SO PERSPECTIVES ON POLITICS LA English DT Book Review C1 [Perez, Celestino, Jr.] US Army Command, Ft Leavenworth, KS USA. [Perez, Celestino, Jr.] Gen Staff Coll, Ft Leavenworth, KS USA. RP Perez, C (reprint author), US Army War Coll, Carlisle, PA 17013 USA. EM perez.celestino@gmail.com NR 13 TC 1 Z9 1 U1 0 U2 2 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 1537-5927 EI 1541-0986 J9 PERSPECT POLIT JI Perspect. Polit. PD JUN PY 2015 VL 13 IS 2 BP 449 EP 454 DI 10.1017/S1537592715000274 PG 6 WC Political Science SC Government & Law GA CN7MR UT WOS:000358619200026 ER PT J AU Jackson, JC Albert, PS Zhang, ZW AF Jackson, John C. Albert, Paul S. Zhang, Zhiwei TI A TWO-STATE MIXED HIDDEN MARKOV MODEL FOR RISKY TEENAGE DRIVING BEHAVIOR SO ANNALS OF APPLIED STATISTICS LA English DT Article DE Adaptive quadrature; hidden Markov model; joint model; random effects ID LONGITUDINAL DATA; TRIAL DATA; ALGORITHMS; DRIVERS AB This paper proposes a joint model for longitudinal binary and count outcomes. We apply the model to a unique longitudinal study of teen driving where risky driving behavior and the occurrence of crashes or near crashes are measured prospectively over the first 18 months of licensure. Of scientific interest is relating the two processes and predicting crash and near crash outcomes. We propose a two-state mixed hidden Markov model whereby the hidden state characterizes the mean for the joint longitudinal crash/near crash outcomes and elevated g-force events which are a proxy for risky driving. Heterogeneity is introduced in both the conditional model for the count outcomes and the hidden process using a shared random effect. An estimation procedure is presented using the forward-backward algorithm along with adaptive Gaussian quadrature to perform numerical integration. The estimation procedure readily yields hidden state probabilities as well as providing for a broad class of predictors. C1 [Jackson, John C.] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. [Albert, Paul S.; Zhang, Zhiwei] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Div Intramural Populat Hlth Res, Biostat & Bioinformat, Bethesda, MD 20892 USA. RP Jackson, JC (reprint author), US Mil Acad, Dept Math Sci, Thayer Hall, West Point, NY 10996 USA. EM john.jackson@usma.edu; albertp@mail.nih.gov FU Intramural Research program of the National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development FX Supported by the Intramural Research program of the National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development. NR 19 TC 0 Z9 0 U1 0 U2 4 PU INST MATHEMATICAL STATISTICS PI CLEVELAND PA 3163 SOMERSET DR, CLEVELAND, OH 44122 USA SN 1932-6157 J9 ANN APPL STAT JI Ann. Appl. Stat. PD JUN PY 2015 VL 9 IS 2 BP 849 EP 865 DI 10.1214/14-AOAS765 PG 17 WC Statistics & Probability SC Mathematics GA CN3ZR UT WOS:000358368000014 PM 27766124 ER PT J AU Kerzner, E Butler, LA Hansen, C Meyer, M AF Kerzner, Ethan Butler, Lee A. Hansen, Charles Meyer, Miriah TI A Shot at Visual Vulnerability Analysis SO COMPUTER GRAPHICS FORUM LA English DT Article AB Increasing the safety of vehicles is an important goal for vehicle manufacturers. These manufacturers often turn to simulations to understand how to improve a vehicle's design as real-world safety tests are expensive and time consuming. Understanding the results of these simulations, however, is challenging due to the complexity of the data, which often includes both spatial and nonspatial data types. In this design study we collaborated with analysts who are trying to understand the vulnerability of military vehicles. From this design study we contribute a problem characterization, data abstraction, and task analysis for vehicle vulnerability analysis, as well as a validated and deployed tool called Shotviewer. Shotviewer links 3D spatial views with abstract 2D views to support a broad range of analysis needs. Furthermore, reflection on our design study process elucidates a strategy of view-design parallelism for creating multiview visualizations, as well as four recommendations for conducting design studies in large organizations with sensitive data. C1 [Kerzner, Ethan; Hansen, Charles; Meyer, Miriah] Univ Utah, Salt Lake City, UT 84112 USA. [Butler, Lee A.] US Army Res Lab, Adelphi, MD USA. RP Kerzner, E (reprint author), Univ Utah, Salt Lake City, UT 84112 USA. EM kerzner@sci.utah.edu NR 38 TC 0 Z9 0 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0167-7055 EI 1467-8659 J9 COMPUT GRAPH FORUM JI Comput. Graph. Forum PD JUN PY 2015 VL 34 IS 3 BP 391 EP 400 DI 10.1111/cgf.12651 PG 10 WC Computer Science, Software Engineering SC Computer Science GA CN3LP UT WOS:000358328200042 ER PT J AU Farmer, AR Murray, CK Driscoll, IR Wickes, BL Wiederhold, N Sutton, DA Sanders, C Mende, K Enniss, B Feig, J Ganesan, A Rini, EA Vento, TJ AF Farmer, Aaron R. Murray, Clinton K. Driscoll, Ian R. Wickes, Brian L. Wiederhold, Nathan Sutton, Deanna A. Sanders, Carmita Mende, Katrin Enniss, Brent Feig, James Ganesan, Anuradha Rini, Elizabeth A. Vento, Todd J. TI Combat-Related Pythium aphanidermatum Invasive Wound Infection: Case Report and Discussion of Utility of Molecular Diagnostics SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID IN-VITRO SUSCEPTIBILITY; CENTRAL-NERVOUS-SYSTEM; MOLD INFECTIONS; FUNGAL-INFECTIONS; HUMAN PYTHIOSIS; INSIDIOSUM; SPECIMENS; TRAUMA; IDENTIFICATION; CASPOFUNGIN AB We describe a 22-year-old soldier with 19% total body surface area burns, polytrauma, and sequence- and culture-confirmed Pythium aphanidermatum wound infection. Antemortem histopathology suggested disseminated Pythium infection, including brain involvement; however, postmortem PCR revealed Cunninghamella elegans, Lichtheimia corymbifera, and Saksenaea vasiformis coinfection. The utility of molecular diagnostics in invasive fungal infections is discussed. C1 [Farmer, Aaron R.; Murray, Clinton K.; Mende, Katrin; Enniss, Brent; Vento, Todd J.] JBSA Ft Sam Houston, San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA. [Mende, Katrin; Ganesan, Anuradha] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Wickes, Brian L.] Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol & Immunol, San Antonio, TX 78229 USA. [Wiederhold, Nathan; Sutton, Deanna A.; Sanders, Carmita] Univ Texas Hlth Sci Ctr San Antonio, Fungus Testing Lab, Dept Pathol, San Antonio, TX 78229 USA. [Ganesan, Anuradha] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA. [Rini, Elizabeth A.] Landstuhl Reg Med Ctr, Landstuhl, Germany. [Driscoll, Ian R.] US Army Inst Surg Res, JBSA Ft Sam Houston, Ft Sam Houston, TX USA. [Feig, James] Bexar Cty Med Examiners Off, San Antonio, TX USA. RP Farmer, AR (reprint author), JBSA Ft Sam Houston, San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA. EM Aaron.r.farmer.mil@mail.mil OI Wiederhold, Nathan/0000-0002-2225-5122 FU U.S. Army Medical Research and Materiel Command [W81XWH-13-C-0103]; Army Research Office of the Department of Defense [W911NF-11-1-0136]; Office of Congressionally Directed Medical Research Programs; Joint Warfighter Medical Research Program; Department of the Navy under the Wounded, Ill, and Injured Program; military infectious disease research program [D_MIDCTA_I_12_J2_29] FX A.R.F., C.K.M., I.R.D., E.A.R., and T.J.V. are employees of the U.S. Government. B.L.W. is supported by grant W81XWH-13-C-0103 from the U.S. Army Medical Research and Materiel Command, Office of Congressionally Directed Medical Research Programs, Joint Warfighter Medical Research Program, and the Army Research Office of the Department of Defense under contract no. W911NF-11-1-0136. A.G. was supported by the Department of the Navy under the Wounded, Ill, and Injured Program and the military infectious disease research program D_MIDCTA_I_12_J2_29. NR 39 TC 1 Z9 1 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 EI 1098-660X J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JUN PY 2015 VL 53 IS 6 BP 1968 EP 1975 DI 10.1128/JCM.00410-15 PG 8 WC Microbiology SC Microbiology GA CN2WZ UT WOS:000358284600032 PM 25832301 ER PT J AU Terrill, WA AF Terrill, W. Andrew TI The Good Spy: The Life and Death of Robert Ames SO MIDDLE EAST JOURNAL LA English DT Book Review C1 [Terrill, W. Andrew] US Army War Coll, Strateg Studies Inst, Carlisle, PA 17013 USA. RP Terrill, WA (reprint author), US Army War Coll, Strateg Studies Inst, Carlisle, PA 17013 USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU MIDDLE EAST INST PI WASHINGTON PA 1761 N ST NW, CIRCULATION DEPT, WASHINGTON, DC 20036-2882 USA SN 0026-3141 EI 1940-3461 J9 MIDDLE EAST J JI Middle East J. PD SUM PY 2015 VL 69 IS 3 BP 486 EP 488 PG 3 WC Area Studies SC Area Studies GA CN2SO UT WOS:000358272400021 ER PT J AU Welton, MD AF Welton, Mark D. TI Doubt in Islamic Law: A History of Legal Maxims, Interpretation, and Islamic Criminal Law SO MIDDLE EAST JOURNAL LA English DT Book Review C1 [Welton, Mark D.] US Mil Acad, West Point, NY 10996 USA. RP Welton, MD (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU MIDDLE EAST INST PI WASHINGTON PA 1761 N ST NW, CIRCULATION DEPT, WASHINGTON, DC 20036-2882 USA SN 0026-3141 EI 1940-3461 J9 MIDDLE EAST J JI Middle East J. PD SUM PY 2015 VL 69 IS 3 BP 489 EP 490 PG 2 WC Area Studies SC Area Studies GA CN2SO UT WOS:000358272400023 ER PT J AU Rojhirunsakool, T Darling, KA Tschopp, MA Pun, GPP Mishin, Y Banerjee, R Kecskes, LJ AF Rojhirunsakool, Tanaporn Darling, Kristopher A. Tschopp, Mark A. Pun, Ganga P. Purja Mishin, Yuri Banerjee, Rajarshi Kecskes, Laszlo J. TI Structure and thermal decomposition of a nanocrystalline mechanically alloyed supersaturated Cu-Ta solid solution SO MRS COMMUNICATIONS LA English DT Article ID ATOM-PROBE TOMOGRAPHY; CHANNEL ANGULAR EXTRUSION; FERRITIC ALLOYS; COPPER; STABILIZATION; TANTALUM; SHEAR AB The formation of a metastable Cu-Ta solid solution in a mechanically alloyed Cu-10 at.% Ta alloy and its subsequent decomposition during annealing was investigated by atom probe tomography. During annealing, the as-milled Cu-rich alloy undergoes phase separation; Ta atoms diffuse out of the Cu lattice to form Ta clusters and particles along grain boundaries and within the Cu grains. The role of the Ta clusters and the nature of the solid solution as a potential strengthening mechanism for these alloys are discussed. C1 [Rojhirunsakool, Tanaporn; Banerjee, Rajarshi] Univ N Texas, Ctr Adv Res & Technol, Denton, TX 76203 USA. [Rojhirunsakool, Tanaporn; Banerjee, Rajarshi] Univ N Texas, Dept Mat Sci & Engn, Denton, TX 76203 USA. [Darling, Kristopher A.; Tschopp, Mark A.; Kecskes, Laszlo J.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 20005 USA. [Pun, Ganga P. Purja; Mishin, Yuri] George Mason Univ, Dept Phys & Astron, Fairfax, VA 22030 USA. RP Darling, KA (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 20005 USA. EM kristopher.darling.civ@mail.mil RI Mishin, Yuri/P-2020-2015; OI Tschopp, Mark/0000-0001-8471-5035 NR 25 TC 3 Z9 3 U1 2 U2 11 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 2159-6859 EI 2159-6867 J9 MRS COMMUN JI MRS Commun. PD JUN PY 2015 VL 5 IS 2 BP 333 EP 339 DI 10.1557/mrc.2015.34 PG 7 WC Materials Science, Multidisciplinary SC Materials Science GA CN1AK UT WOS:000358147300026 ER PT J AU Carter, SP AF Carter, Susan Payne TI Payday Loan and Pawnshop Usage: The Impact of Allowing Payday Loan Rollovers SO JOURNAL OF CONSUMER AFFAIRS LA English DT Article AB Millions of US households rely on payday loans and pawnshops for short-term credit. Payday loan interest rates are as high as 25% per 2- to 4-week loans and individuals use a post-dated check to secure the loan. Pawnshop usage is available for anyone with collateral. This article examines whether individuals using payday loans in states where rollovers are allowed are more likely to also use pawnshops together with payday loans. I find that this is true for individuals who make less than $30,000, but it does not hold for those with higher levels of income. There may be some complementary relationships between payday loan rollovers and pawnshops for these lower-income individuals. These results are important when considering whether to allow payday loan rollovers. C1 US Mil Acad, Dept Social Sci, Off Econ & Manpower Anal, West Point, NY 10996 USA. RP Carter, SP (reprint author), US Mil Acad, Dept Social Sci, Off Econ & Manpower Anal, West Point, NY 10996 USA. EM susan.carter@usma.edu FU Vanderbilt Dissertation Fellowship FX I would first of all like to thank the Vanderbilt Dissertation Fellowship for funding my final year of research at Vanderbilt. In addition, I would like to thank my dissertation committee William Collins, Andrew Daughety, Miguel Palacios, Paige Skiba, and Jennifer Reinganum for their helpful comments. I received numerous other helpful comments at seminars at various institutions while on the job market, and I am extremely grateful for all feedback. The views expressed in this article are those of the author and do not reflect the official policy or position of the Department of the Army, Department of Defense (DOD), or the US Government. All mistakes are my own. NR 23 TC 1 Z9 1 U1 1 U2 11 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0022-0078 EI 1745-6606 J9 J CONSUM AFF JI J. Consum. Aff. PD SUM PY 2015 VL 49 IS 2 BP 436 EP 456 DI 10.1111/joca.12072 PG 21 WC Business; Economics SC Business & Economics GA CM7PD UT WOS:000357886200006 ER PT J AU Stearns, LA Hamilton, GS van der Veen, CJ Finnegan, DC O'Neel, S Scheick, JB Lawson, DE AF Stearns, L. A. Hamilton, G. S. van der Veen, C. J. Finnegan, D. C. O'Neel, S. Scheick, J. B. Lawson, D. E. TI Glaciological and marine geological controls on terminus dynamics of Hubbard Glacier, southeast Alaska SO JOURNAL OF GEOPHYSICAL RESEARCH-EARTH SURFACE LA English DT Article DE glacier dynamics; calving processes; remote sensing; ice-ocean interactions ID TIDEWATER GLACIER; LECONTE GLACIER; MELT; GREENLAND; ADVANCE; USA; VELOCITY; CLIMATE; RETREAT; SYSTEM AB Hubbard Glacier, located in southeast Alaska, is the world's largest nonpolar tidewater glacier. It has been steadily advancing since it was first mapped in 1895; occasionally, the advance creates an ice or sediment dam that blocks a tributary fjord (Russell Fiord). The sustained advance raises the probability of long-term closure in the near future, which will strongly impact the ecosystem of Russell Fiord and the nearby community of Yakutat. Here, we examine a 43year record of flow speeds and terminus position to understand the large-scale dynamics of Hubbard Glacier. Our long-term record shows that the rate of terminus advance has increased slightly since 1895, with the exception of a slowed advance between approximately 1972 and 1984. The short-lived closure events in 1986 and 2002 were not initiated by perturbations in ice velocity or environmental forcings but were likely due to fluctuations in sedimentation patterns at the terminus. This study points to the significance of a coupled system where short-term velocity fluctuations and morainal shoal development control tidewater glacier terminus position. C1 [Stearns, L. A.] Univ Kansas, Dept Geol, Lawrence, KS 66045 USA. [Hamilton, G. S.; Scheick, J. B.] Univ Maine, Sch Earth & Climate Sci, Orono, ME USA. [van der Veen, C. J.] Univ Kansas, Dept Geog, Lawrence, KS 66045 USA. [Finnegan, D. C.; Lawson, D. E.] USACE Cold Reg Res & Engn Lab, Hanover, NH USA. [O'Neel, S.] USGS, Alaska Sci Ctr, Anchorage, AK USA. RP Stearns, LA (reprint author), Univ Kansas, Dept Geol, Lawrence, KS 66045 USA. EM stearns@ku.edu FU NSF RAPID [NSF-OPP/ARC-094977] FX The supporting information list images used in this study to derive terminus area and ice velocity. Ice velocity and terminus data products are available on the CRREL glacier data repository: www.glacierresearch.org/locations/hubbard/satellite-data. This work was partially funded by an NSF RAPID grant awarded to D. Lawson (NSF-OPP/ARC-094977). The authors would also like to thank the community of Yakutat and the US Army Corps of Engineers-Alaska District, Anchorage, Alaska. We thank Martin Truffer, Roman Motyka, and Jeremy Bassis for providing insightful edits that greatly improved this manuscript. NR 49 TC 6 Z9 6 U1 4 U2 10 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-9003 EI 2169-9011 J9 J GEOPHYS RES-EARTH JI J. Geophys. Res.-Earth Surf. PD JUN PY 2015 VL 120 IS 6 BP 1065 EP 1081 DI 10.1002/2014JF003341 PG 17 WC Geosciences, Multidisciplinary SC Geology GA CM8ZQ UT WOS:000357994400007 ER PT J AU Sozhamannan, S Holland, MY Hall, AT Negron, DA Ivancich, M Koehler, JW Minogue, TD Campbell, CE Berger, WJ Christopher, GW Goodwin, BG Smith, MA AF Sozhamannan, Shanmuga Holland, Mitchell Y. Hall, Adrienne T. Negron, Daniel A. Ivancich, Mychal Koehler, Jeffrey W. Minogue, Timothy D. Campbell, Catherine E. Berger, Walter J. Christopher, George W. Goodwin, Bruce G. Smith, Michael A. TI Evaluation of Signature Erosion in Ebola Virus Due to Genomic Drift and Its Impact on the Performance of Diagnostic Assays SO VIRUSES-BASEL LA English DT Article ID OUTBREAK; RNA; DNA AB Genome sequence analyses of the 2014 Ebola Virus (EBOV) isolates revealed a potential problem with the diagnostic assays currently in use; i.e., drifting genomic profiles of the virus may affect the sensitivity or even produce false-negative results. We evaluated signature erosion in ebolavirus molecular assays using an in silico approach and found frequent potential false-negative and false-positive results. We further empirically evaluated many EBOV assays, under real time PCR conditions using EBOV Kikwit (1995) and Makona (2014) RNA templates. These results revealed differences in performance between assays but were comparable between the old and new EBOV templates. Using a whole genome approach and a novel algorithm, termed BioVelocity, we identified new signatures that are unique to each of EBOV, Sudan virus (SUDV), and Reston virus (RESTV). Interestingly, many of the current assay signatures do not fall within these regions, indicating a potential drawback in the past assay design strategies. The new signatures identified in this study may be evaluated with real-time reverse transcription PCR (rRT-PCR) assay development and validation. In addition, we discuss regulatory implications and timely availability to impact a rapidly evolving outbreak using existing but perhaps less than optimal assays versus redesign these assays for addressing genomic changes. C1 [Sozhamannan, Shanmuga; Goodwin, Bruce G.; Smith, Michael A.] Med Countermeasure Syst Annex, Crit Reagents Program, Frederick, MD 21702 USA. [Sozhamannan, Shanmuga] Tauri Grp LLC, Alexandria, VA 22310 USA. [Holland, Mitchell Y.; Negron, Daniel A.; Ivancich, Mychal; Berger, Walter J.] Noblis Inc, Falls Church, VA 22042 USA. [Hall, Adrienne T.; Koehler, Jeffrey W.; Minogue, Timothy D.] US Army Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. [Campbell, Catherine E.] DCE Consulting, Vienna, VA 22181 USA. [Christopher, George W.] Med Countermeasure Syst, Ft Belvoir, VI 22060 USA. RP Sozhamannan, S (reprint author), Med Countermeasure Syst Annex, Crit Reagents Program, 110 Thomas Johnson Dr, Frederick, MD 21702 USA. EM shanmuga.sozhamannan.ctr@mail.mil; mitchell.holland@noblis.org; adrienne.t.hall2.civ@mail.mil; daniel.negron@noblis.org; mychal.ivancich@noblis.org; jeff.w.koehler.ctr@mail.mil; timothy.d.minogue.civ@mail.mil; dceconsulting@verizon.net; walter.berger@noblis.org; george.w.christopher.civ@mail.mil; bruce.g.goodwin4.civ@mail.mil; michael.a.smith215.civ@mail.mil OI Koehler, Jeffrey/0000-0003-3225-6599 FU Defense Threat Reduction Agency (DTRA) [CB3901] FX Work conducted at Noblis, Advanced Analytics for Bioinformatics within the Center for Applied High Performance Computing, was supported by internal research and development funds targeted to aid in the response to the 2014 Western African EBOV epidemic. Work performed at USAMRIID was supported by funding from Defense Threat Reduction Agency (DTRA) under grant # CB3901 to TDM. The authors would like to thank Amanda Horstman-Smith and Fedora Daye for many useful comments that improved the manuscript immensely and A. Scott Brown for help with graphics. The views expressed here are those of the authors and do not necessarily represent the views or official position of CRP, JPM-MCS or DoD. The CRP/MCS authors MAS, BBG are US Government employees and this work was prepared as part of their official duties. Title 17 U.S.C. Ag105 provides that "Copyright protection under this title is not available for any work of the United States Government." Title 17 U.S.C. Ag101 defines a U.S. Government work as a work prepared by a military service member or employee of the U.S. Government as part of that person's official duties. NR 29 TC 7 Z9 7 U1 0 U2 3 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1999-4915 J9 VIRUSES-BASEL JI Viruses-Basel PD JUN PY 2015 VL 7 IS 6 BP 3130 EP 3154 DI 10.3390/v7062763 PG 25 WC Virology SC Virology GA CM6LC UT WOS:000357799000019 PM 26090727 ER PT J AU Creech, CT Siqueira, RB Selegean, JP Miller, C AF Creech, Calvin T. Siqueira, Rafael Brito Selegean, James P. Miller, Carol TI Anthropogenic impacts to the sediment budget of Sao Francisco River navigation channel using SWAT SO INTERNATIONAL JOURNAL OF AGRICULTURAL AND BIOLOGICAL ENGINEERING LA English DT Article DE sediment budget; aggradation rate; Sao Francisco River; anthropogenic impact; SWAT ID WATER ASSESSMENT-TOOL; MODEL DEVELOPMENT; COASTAL OCEAN; SOIL; CALIBRATION; QUALITY; HUMANS; YIELD; INDIA; AREA AB The Sao Francisco River Basin, located in eastern Brazil, has undergone a significant amount of anthropogenic changes in the last several decades, such as agricultural expansion, irrigation activities, mining, and the construction of large dams. Together, these changes have altered the historic sediment budget and have led to an aggradation of sediments in the navigation channel, impacting the ability to efficiently ship agricultural commodities to regional ports. In an effort to aid decision makers in future waterway navigation planning, an international partnership between the Brazilian government agency CODEVASF and the US Army Corps of Engineers (USACE) was created. Through this partnership a SWAT model of the 630 000 km(2) Sao Francisco River basin was developed to better understand both the historic and current sediment budget within the navigation channel. The SWAT model of the Sao Francisco River Basin was calibrated for hydrology and sediment loads. Monthly discharges were calibrated at 17 Agencia Nacional de Aguas (ANA) gages, with Nash-Sutcliffe efficiency (NSE) values ranging from 0.42 to 0.75 for an eleven year simulation. Sediment loads were calibrated to an ANA sediment gage located in the Middle Sao Francisco River Navigation Channel, with a PBIAS (Percent Bias) of 11.6. Based on model results, the aggradation rate of sediment in the Sao Francisco River and major tributaries has increased by approximately 20 Mt since Pre-European settlement of the basin (from approximately 7 Mt/a to 27 Mt/a). This increase has contributed to an impaired navigation channel due to shoaling of sandy sediments in the navigation channel. C1 [Creech, Calvin T.; Miller, Carol] Wayne State Univ, Detroit, MI 48202 USA. [Siqueira, Rafael Brito] Companhia Desenvolvimento Vales Sao Francisco & P, BR-70830 Brasilia, DF, Brazil. [Selegean, James P.] US Army Corps Engineers, Detroit, MI 48226 USA. [Creech, Calvin T.] US Army Corps Engineers, Mobile, AL 36628 USA. RP Creech, CT (reprint author), Wayne State Univ, Detroit, MI 48202 USA. EM Calvin.T.Creech@usace.army.mil; rafael.siqueira@codevasf.gov.br; James.P.Selegean@usace.army.mil; ab1421@wayne.edu NR 55 TC 4 Z9 4 U1 3 U2 11 PU CHINESE ACAD AGRICULTURAL ENGINEERING PI BEIJING PA RM 506, 41, MAIZIDIAN ST, CHAOYANG DISTRICT, BEIJING, 100125, PEOPLES R CHINA SN 1934-6344 EI 1934-6352 J9 INT J AGR BIOL ENG JI Int. J. Agric. Biol. Eng. PD JUN PY 2015 VL 8 IS 3 SI SI BP 140 EP 157 DI 10.3965/j.ijabe.20150803.1372 PG 18 WC Agricultural Engineering SC Agriculture GA CM2UD UT WOS:000357536900011 ER PT J AU Cheuvront, SN Kenefick, RW Zambraski, EJ AF Cheuvront, Samuel N. Kenefick, Robert W. Zambraski, Edward J. TI Spot Urine Concentrations Should Not be Used for Hydration Assessment: A Methodology Review SO INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM LA English DT Review DE urine specific gravity; urine osmolality; urine color ID ANTIDIURETIC-HORMONE; BIOLOGICAL VARIATION; ACUTE DEHYDRATION; SOCCER PLAYERS; SODIUM-BALANCE; FLUID INTAKE; 24-H URINE; GRAVITY; WATER; OSMOLALITY AB A common practice in sports science is to assess hydration status using the concentration of a single spot urine collection taken at any time of day for comparison against concentration (specific gravity, osmolality, color) thresholds established from first morning voids. There is strong evidence that this practice can be confounded by fluid intake, diet, and exercise, among other factors, leading to false positive/negative assessments. Thus, the purpose of this paper is to provide a simple explanation as to why this practice leads to erroneous conclusions and should be curtailed in favor of consensus hydration assessment recommendations. C1 [Cheuvront, Samuel N.; Kenefick, Robert W.; Zambraski, Edward J.] US Army, Environm Med Res Inst, Natick, MA 01760 USA. RP Cheuvront, SN (reprint author), US Army, Environm Med Res Inst, Natick, MA 01760 USA. EM samuel.n.cheuvront.civ@mail.mil NR 47 TC 7 Z9 7 U1 3 U2 12 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA SN 1526-484X EI 1543-2742 J9 INT J SPORT NUTR EXE JI Int. J. Sport Nutr. Exerc. Metab. PD JUN PY 2015 VL 25 IS 3 BP 293 EP 297 DI 10.1123/ijsnem.2014-0138 PG 5 WC Nutrition & Dietetics; Sport Sciences SC Nutrition & Dietetics; Sport Sciences GA CM4NK UT WOS:000357661300009 PM 25386829 ER PT J AU Buchta, JN Zarndt, BS Garver, LS Rowland, T Shi, M Davidson, SA Rowton, ED AF Buchta, Jessica N. Zarndt, Bethany S. Garver, Lindsey S. Rowland, Tobin Shi, Meng Davidson, Silas A. Rowton, Edgar D. TI BLOOD-FEEDING BEHAVIORS OF ANOPHELES STEPHENSI BUT NOT PHLEBOTOMUS PAPATASI ARE INFLUENCED BY ACTIVELY WARMING GUINEA PIGS (CAVIA PORCELLUS) UNDER GENERAL ANESTHESIA SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article DE Anopheles stephensi; Phlebotomus papatasi; core body temperature; blood feeding; host seeking ID HOST; TEMPERATURE; MOSQUITOS; RESPONSES; DIPTERA; CULICIDAE; SKIN AB Animal models are often used to study hematophagous insect feeding behavior and evaluate products such as topical repellents. However, when these models are used the study animals often experience significant drops in core body temperature because of the effects of anesthesia. This study used a guinea pig model to investigate whether maintaining a normothermic core body temperature during anesthesia influenced the rate of Anopheles stephensi and Phlebotomus papatasi blood feeding. Experiments were conducted with anesthetized animals that had their body temperatures either maintained with a warming device or were allowed to drop naturally. Results showed that when guinea pigs were actively warmed by a heating device, An. stephensi feeding behavior was similar at the beginning and end of anesthesia. However, when a warming device was not used, fewer An. stephensi took a blood meal after the animals' temperatures had dropped. Phlebotomus papatasi were not as sensitive to changes in temperature and feeding rates were similar whether a warming device was used or not. These results are discussed and it is recommended that warming devices are used when conducting feeding experiments with insects sensitive to changes in host body temperature, such as An. stephensi. C1 [Buchta, Jessica N.; Zarndt, Bethany S.] Walter Reed Army Inst Res, Vet Med, Silver Spring, MD 20910 USA. [Garver, Lindsey S.; Rowland, Tobin; Davidson, Silas A.; Rowton, Edgar D.] Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD USA. [Shi, Meng] Walter Reed Army Inst Res, Div Med Audio Visual Lib & Stat Serv, Silver Spring, MD 20910 USA. RP Buchta, JN (reprint author), Walter Reed Army Inst Res, Vet Med, 511 Robert Grant Ave, Silver Spring, MD 20910 USA. NR 25 TC 0 Z9 0 U1 0 U2 3 PU AMER MOSQUITO CONTROL ASSOC PI MOUNT LAUREL PA 15000 COMMERCE PARKWAY, SUITE C, MOUNT LAUREL, NJ 08054 USA SN 8756-971X EI 1943-6270 J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD JUN PY 2015 VL 31 IS 2 BP 149 EP 154 PG 6 WC Entomology SC Entomology GA CM5DM UT WOS:000357707000004 PM 26181690 ER PT J AU Murdoch, HA Darling, KA Roberts, AJ Kecskes, L AF Murdoch, Heather A. Darling, Kristopher A. Roberts, Anthony J. Kecskes, Laszlo TI Mechanical Behavior of Ultrafine Gradient Grain Structures Produced via Ambient and Cryogenic Surface Mechanical Attrition Treatment in Iron SO METALS LA English DT Article ID SEVERE PLASTIC-DEFORMATION; HIGH-TENSILE DUCTILITY; NANOCRYSTALLINE COPPER; CORROSION BEHAVIOR; METALS; FE; CU; TEMPERATURES; REFINEMENT; ALLOY C1 [Murdoch, Heather A.; Darling, Kristopher A.; Roberts, Anthony J.; Kecskes, Laszlo] US Army Res Lab, Weap & Mat Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Murdoch, HA (reprint author), US Army Res Lab, Weap & Mat Directorate, Aberdeen Proving Ground, MD 21005 USA. EM heather.a.murdoch.civ@mail.mil; kristopher.a.darling.civ@mail.mil; anthony.j.roberts69.ctr@mail.mil; laszlo.j.kecskes.civ@mail.mil FU U.S. Army Research Laboratory FX The authors would like to acknowledge Jim Catalano (ARL), Tom Luckenbaugh (Bowhead) and Micah Gallagher (Bowhead) for valuable experimental input. AJR would like to acknowledge support from the U.S. Army Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and ARL. NR 40 TC 3 Z9 3 U1 5 U2 14 PU MDPI AG PI BASEL PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND SN 2075-4701 J9 METALS-BASEL JI Metals PD JUN PY 2015 VL 5 IS 2 BP 976 EP 985 PG 10 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA CM2KJ UT WOS:000357508400032 ER PT J AU Goodson, WH Lowe, L Carpenter, DO Gilbertson, M Ali, AM Salsamendi, ALD Lasfar, A Carnero, A Azqueta, A Amedei, A Charles, AK Collins, AR Ward, A Salzberg, AC Colacci, A Olsen, AK Berg, A Barclay, BJ Zhou, BHP Blanco-Aparicio, C Baglole, CJ Dong, CF Mondello, C Hsu, CW Naus, CC Yedjou, C Curran, CS Laird, DW Koch, DC Carlin, DJ Felsher, DW Roy, D Brown, DG Ratovitski, E Ryan, EP Corsini, E Rojas, E Moon, EY Laconi, E Marongiu, F Al-Mulla, F Chiaradonna, F Darroudi, F Martin, FL Van Schooten, FJ Goldberg, GS Wagemaker, G Nangami, G Calaf, GM Williams, G Wolf, GT Koppen, G Brunborg, G Lyerly, HK Krishnan, H Ab Hamid, H Yasaei, H Sone, H Kondoh, H Salem, HK Hsu, HY Park, HH Koturbash, I Miousse, IR Scovassi, AI Klaunig, JE Vondracek, J Raju, J Roman, J Wise, JP Whitfield, JR Woodrick, J Christopher, JA Ochieng, J Martinez-Leal, JF Weisz, J Kravchenko, J Sun, J Prudhomme, KR Narayanan, KB Cohen-Solal, KA Moorwood, K Gonzalez, L Soucek, L Jian, L D'Abronzo, LS Lin, LT Li, L Gulliver, L McCawley, LJ Memeo, L Vermeulen, L Leyns, L Zhang, LP Valverde, M Khatami, M Romano, MF Chapellier, M Williams, MA Wade, M Manjili, MH Lleonart, M Xia, MH Gonzalez, MJ Karamouzis, MV Kirsch-Volders, M Vaccari, M Kuemmerle, NB Singh, N Cruickshanks, N Kleinstreuer, N van Larebeke, N Ahmed, N Ogunkua, O Krishnakumar, PK Vadgama, P Marignani, PA Ghosh, PM Ostrosky-Wegman, P Thompson, P Dent, P Heneberg, P Darbre, P Leung, PS Nangia-Makker, P Cheng, Q Robey, RB Al-Temaimi, R Roy, R Andrade-Vieira, R Sinha, RK Mehta, R Vento, R Di Fiore, R Ponce-Cusi, R Dornetshuber-Fleiss, R Nahta, R Castellino, RC Palorini, R Abd Hamid, R Langie, SAS Eltom, S Brooks, SA Ryeom, S Wise, SS Bay, SN Harris, SA Papagerakis, S Romano, S Pavanello, S Eriksson, S Forte, S Casey, SC Luanpitpong, S Lee, TJ Otsuki, T Chen, T Massfelder, T Sanderson, T Guarnieri, T Hultman, T Dormoy, V Odero-Marah, V Sabbisetti, V Maguer-Satta, V Rathmell, WK Engstrom, W Decker, WK Bisson, WH Rojanasakul, Y Luqmani, Y Chen, ZB Hu, ZW AF Goodson, William H., III Lowe, Leroy Carpenter, David O. Gilbertson, Michael Ali, Abdul Manaf de Cerain Salsamendi, Adela Lopez Lasfar, Ahmed Carnero, Amancio Azqueta, Amaya Amedei, Amedeo Charles, Amelia K. Collins, Andrew R. Ward, Andrew Salzberg, Anna C. Colacci, Annamaria Olsen, Ann-Karin Berg, Arthur Barclay, Barry J. Zhou, Binhua P. Blanco-Aparicio, Carmen Baglole, Carolyn J. Dong, Chenfang Mondello, Chiara Hsu, Chia-Wen Naus, Christian C. Yedjou, Clement Curran, Colleen S. Laird, Dale W. Koch, Daniel C. Carlin, Danielle J. Felsher, Dean W. Roy, Debasish Brown, Dustin G. Ratovitski, Edward Ryan, Elizabeth P. Corsini, Emanuela Rojas, Emilio Moon, Eun-Yi Laconi, Ezio Marongiu, Fabio Al-Mulla, Fahd Chiaradonna, Ferdinando Darroudi, Firouz Martin, Francis L. Van Schooten, Frederik J. Goldberg, Gary S. Wagemaker, Gerard Nangami, Gladys Calaf, Gloria M. Williams, Graeme Wolf, Gregory T. Koppen, Gudrun Brunborg, Gunnar Lyerly, H. Kim Krishnan, Harini Ab Hamid, Hasiah Yasaei, Hemad Sone, Hideko Kondoh, Hiroshi Salem, Hosni K. Hsu, Hsue-Yin Park, Hyun Ho Koturbash, Igor Miousse, Isabelle R. Scovassi, A. Ivana Klaunig, James E. Vondracek, Jan Raju, Jayadev Roman, Jesse Wise, John Pierce, Sr. Whitfield, Jonathan R. Woodrick, Jordan Christopher, Joseph A. Ochieng, Josiah Fernando Martinez-Leal, Juan Weisz, Judith Kravchenko, Julia Sun, Jun Prudhomme, Kalan R. Narayanan, Kannan Badri Cohen-Solal, Karine A. Moorwood, Kim Gonzalez, Laetitia Soucek, Laura Jian, Le D'Abronzo, Leandro S. Lin, Liang-Tzung Li, Lin Gulliver, Linda McCawley, Lisa J. Memeo, Lorenzo Vermeulen, Louis Leyns, Luc Zhang, Luoping Valverde, Mahara Khatami, Mahin Romano, Maria Fiammetta Chapellier, Marion Williams, Marc A. Wade, Mark Manjili, Masoud H. Lleonart, Matilde Xia, Menghang Gonzalez, Michael J. Karamouzis, Michalis V. Kirsch-Volders, Micheline Vaccari, Monica Kuemmerle, Nancy B. Singh, Neetu Cruickshanks, Nichola Kleinstreuer, Nicole van Larebeke, Nik Ahmed, Nuzhat Ogunkua, Olugbemiga Krishnakumar, P. K. Vadgama, Pankaj Marignani, Paola A. Ghosh, Paramita M. Ostrosky-Wegman, Patricia Thompson, Patricia Dent, Paul Heneberg, Petr Darbre, Philippa Leung, Po Sing Nangia-Makker, Pratima Cheng, Qiang (Shawn) Robey, R. Brooks Al-Temaimi, Rabeah Roy, Rabindra Andrade-Vieira, Rafaela Sinha, Ranjeet K. Mehta, Rekha Vento, Renza Di Fiore, Riccardo Ponce-Cusi, Richard Dornetshuber-Fleiss, Rita Nahta, Rita Castellino, Robert C. Palorini, Roberta Abd Hamid, Roslida Langie, Sabine A. S. Eltom, Sakina Brooks, Samira A. Ryeom, Sandra Wise, Sandra S. Bay, Sarah N. Harris, Shelley A. Papagerakis, Silvana Romano, Simona Pavanello, Sofia Eriksson, Staffan Forte, Stefano Casey, Stephanie C. Luanpitpong, Sudjit Lee, Tae-Jin Otsuki, Takemi Chen, Tao Massfelder, Thierry Sanderson, Thomas Guarnieri, Tiziana Hultman, Tove Dormoy, Valerian Odero-Marah, Valerie Sabbisetti, Venkata Maguer-Satta, Veronique Rathmell, W. Kimryn Engstrom, Wilhelm Decker, William K. Bisson, William H. Rojanasakul, Yon Luqmani, Yunus Chen, Zhenbang Hu, Zhiwei TI Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead SO CARCINOGENESIS LA English DT Review ID BREAST-CANCER CELLS; ESTROGEN-RECEPTOR-ALPHA; EPITHELIAL-MESENCHYMAL TRANSITION; VASCULAR ENDOTHELIAL-CELLS; ARYL-HYDROCARBON RECEPTOR; ACTIVATED PROTEIN-KINASES; POLYBROMINATED DIPHENYL ETHERS; ENDOCRINE-DISRUPTING CHEMICALS; BISPHENOL-A EXPOSURE; SPRAGUE-DAWLEY RATS AB Low-dose exposures to common environmental chemicals that are deemed safe individually may be combining to instigate carcinogenesis, thereby contributing to the incidence of cancer. This risk may be overlooked by current regulatory practices and needs to be vigorously investigated.Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of cancers attributable to toxic environmental exposures is between 7% and 19%. To explore the hypothesis that low-dose exposures to mixtures of chemicals in the environment may be combining to contribute to environmental carcinogenesis, we reviewed 11 hallmark phenotypes of cancer, multiple priority target sites for disruption in each area and prototypical chemical disruptors for all targets, this included dose-response characterizations, evidence of low-dose effects and cross-hallmark effects for all targets and chemicals. In total, 85 examples of chemicals were reviewed for actions on key pathways/mechanisms related to carcinogenesis. Only 15% (13/85) were found to have evidence of a dose-response threshold, whereas 59% (50/85) exerted low-dose effects. No dose-response information was found for the remaining 26% (22/85). Our analysis suggests that the cumulative effects of individual (non-carcinogenic) chemicals acting on different pathways, and a variety of related systems, organs, tissues and cells could plausibly conspire to produce carcinogenic synergies. Additional basic research on carcinogenesis and research focused on low-dose effects of chemical mixtures needs to be rigorously pursued before the merits of this hypothesis can be further advanced. However, the structure of the World Health Organization International Programme on Chemical Safety 'Mode of Action' framework should be revisited as it has inherent weaknesses that are not fully aligned with our current understanding of cancer biology. C1 [Goodson, William H., III] Calif Pacific Med Ctr, Res Inst, San Francisco, CA 94115 USA. 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[Guarnieri, Tiziana] S Orsola Malpighi Univ Hosp, Ctr Appl Biomed Res, I-40126 Bologna, Italy. [Guarnieri, Tiziana] Natl Inst Biostruct & Biosyst, I-00136 Rome, Italy. [Hultman, Tove; Engstrom, Wilhelm] Swedish Univ Agr Sci, Fac Vet Med, Dept Biosci & Vet Publ Hlth, S-75007 Uppsala, Sweden. [Dormoy, Valerian] Univ Calif Irvine, Dept Cell & Dev Biol, Irvine, CA 92697 USA. [Odero-Marah, Valerie] Clark Atlanta Univ, Dept Biol, Ctr Canc Res & Therapeut Dev, Atlanta, GA 30314 USA. [Sabbisetti, Venkata] Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA. [Decker, William K.] Baylor Coll Med, Houston, TX 77030 USA. [Rojanasakul, Yon] W Virginia Univ, Dept Pharmaceut Sci, Morgantown, WV 26506 USA. [Luqmani, Yunus] Kuwait Univ, Fac Pharm, Dept Pharmaceut Chem, Safat 13110, Kuwait. [Hu, Zhiwei] Ohio State Univ, Coll Med, Dept Surg, James Comprehens Canc Ctr, Columbus, OH 43210 USA. RP Goodson, WH (reprint author), Calif Pacific Med Ctr, Res Inst, 2100 Webster St 401, San Francisco, CA 94115 USA. EM whg3md@att.net; leroy.lowe@gettingtoknowcancer.org RI Massfelder, Thierry/I-1260-2016; Dormoy, Valerian/P-5109-2016; Marongiu, Fabio/E-6294-2016; Robey, R. Brooks/J-7099-2013; Forte, Stefano/D-3645-2013; Vermeulen, Louis/B-7488-2008; Jian, Le/B-9180-2012; Laird, Dale /E-4176-2015; Hu, Zhiwei/L-3727-2013; Wade, Mark /B-6719-2009; Lopez de Cerain, Adela/L-4572-2014; IBIS, CANCER/P-3323-2015; CHIARADONNA, Ferdinando/K-4959-2016; Gonzalez, Laetitia/F-5116-2011; Leung, Po Sing/P-5758-2014; Heneberg, Petr/C-1881-2012; Vondracek, Jan/J-3037-2012; Mondello, Chiara/B-8305-2015; OI Marongiu, Fabio/0000-0001-5860-4227; Robey, R. Brooks/0000-0001-5059-3965; Forte, Stefano/0000-0001-5746-7451; Roy, Debasish/0000-0001-6590-0569; Valverde, Mahara/0000-0001-6975-1185; Luanpitpong, Sudjit/0000-0002-1639-4935; Vermeulen, Louis/0000-0002-6066-789X; Hu, Zhiwei/0000-0002-0023-1170; Wade, Mark /0000-0002-2688-5965; Lopez de Cerain, Adela/0000-0002-2085-1289; CHIARADONNA, Ferdinando/0000-0001-8529-2732; Gonzalez, Laetitia/0000-0003-4182-3428; Heneberg, Petr/0000-0002-0703-951X; Vondracek, Jan/0000-0003-4071-1969; Kleinstreuer, Nicole/0000-0002-7914-3682; Nangia-Makker, Pratima/0000-0002-1917-169X; Blanco-Aparicio, Carmen/0000-0002-3249-6595; Soucek, Laura/0000-0002-4750-7971; Whitfield, Jonathan/0000-0002-4925-7283; Barclay, Barry/0000-0002-8325-115X; Mondello, Chiara/0000-0002-8379-9246; Scovassi, Anna Ivana/0000-0003-3484-9881; L Martin, Francis/0000-0001-8562-4944 FU National Institute of Health-National Institute of Environmental Health Sciences (NIEHS) [R13ES023276]; California Breast Cancer Research Program; Clarence Heller Foundation; California Pacific Medical Center Foundation; University of Sultan Zainal Abidin, Malaysia; Rutgers Cancer Institute of New Jersey; Research Council of Norway (RCN) through its Centres of Excellence funding scheme [223268/F50]; Spanish Ministry of Economy and Competitivity, ISCIII [Fis: PI12/00137, RTICC: RD12/0036/0028]; FEDER from Regional Development European Funds (European Union); Consejeria de Ciencia e Innovacion [CTS-1848]; Consejeria de Salud of the Junta de Andalucia [PI-0306-2012]; Ministerio de Educacion y Ciencia (Juande la Cierva' programme) of the Spanish Government; Italian Ministry of University and Research [2009FZZ4XM_002]; University of Florence; University of Oslo; Emilia-Romagna Region - Project 'Supersite' in Italy; Fonds de recherche du Quebec-Sante (FRQ-S); Fondazione Cariplo in Milan, Italy [2011-0370]; National Institutes of Health (NIH-NIMHD) [G12MD007581]; Burroughs Wellcome Fund Postdoctoral Enrichment Award; Timor Biology Training grant [NIH T32CA09151]; United States Department of Health and Human Services, NIH [R01 CA170378 PQ22, RO1 CA184384, U54 CA149145, U54 CA151459, P50 CA114747, 1121 CA169964]; CONACyT [152473]; AIRC (Italian Association for Cancer Research) [IG 14640]; Sardinian Regional Government (RAS); Public Problem-Solving Program [NRF-015M3C8A6A06014500]; National Research Foundation of Korea (NRF) [2013M2B2A9A03051296, 2010-0018545]; Ministry of Education, Science and Technology (MEST) in Korea; Kuwait Foundation for the Advancement of Sciences [2011-1302-06]; SysBioNet, a grant for the Italian Roadmap of European Strategy Forum on Research Infrastructures (ESFRI); AIRC (Associazione Italiana Ricerca sul Cancro) [IG 15364]; Rosemere Cancer Foundation; New Jersey Health Foundation; Fondo Nacional de Ciencia y Tecnologia (FONDECYT), Ministerio de Educacion de Chile (MINEDUC), Universidad de Tarapao (UTA); Flemish Institute for Technological Research (VITO), Belgium; National Centre for the Replacement, Refinement and Reduction (NC3Rs) of animals in research [NC.K500045.1, G0800697]; Ministry of Education, Culture, Sports, Science, and Technology of Japan; Japan Science and Technology Agency; JST, CREST; Ministry of Science and Technology of Taiwan [NSC93-2314-B-320-006, NSC94-2314-B-320-002]; National Research Foundation of Korea (NRF) of the Ministry of Education, Science and Technology [2012R1A2A2A01010870]; Ministry of Health and Welfare, Republic of Korea [HI13C1449]; UAMS/NIH Clinical and Translational Science Award [UL1TR000039, KL2TR000063]; Arkansas Biosciences Institute; Czech Science Foundation [13-07711S]; NIH [CA116812]; National Institute of Environmental Health Sciences [ES016893]; Maine Center for Toxicology and Environmental Health; FERO Foundation in Barcelona, Spain; Cancer Research UK; International Journal of Experimental Pathology; Swim Across America Cancer Research Award; American Cancer Society [116683-RSG-09-087-01-TBE]; Fund for Scientific Research-Flanders (FWO-Vlaanderen); Inter University Attraction Pole grant [IAP-P7-07]; Miguel Servet Research Contract Program [CP10/00656]; Taipei Medical University [TMU101-AE3-Y19]; Genesis Oncology Trust (NZ) Professional Development Grant; Faculty of Medicine, University of Otago, Dunedin, New Zealand; Dutch Cancer Society [UVA2011-4969]; AICR [14-1164]; Breast Cancer Research Program [W81XWH-14-1-0087]; Department of Science and Technology, Government of India [SR/FT/LS-063/2008]; NIEHS contracts [N01-ES 35504, HHSN27320140003C]; King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia [T.K. 11-0629]; Dalhousie Medical Research Foundation; Beatrice Hunter Cancer Institute; CIHR; Nova Scotia Lung Association; PHS grants from the NIH [R01-CA141704, R01-CA150214, R01-DK52825, R01-CA61774]; Charles University in Prague [UNCE 204015, PRVOUK P31/2012]; Health and Medical Research Fund of Food and Health Bureau, Hong Kong Special Administrative Region [10110021]; [PI12/01104]; [CP03/00101] FX We gratefully acknowledge the support of the National Institute of Health-National Institute of Environmental Health Sciences (NIEHS) conference grant travel support (R13ES023276); Glenn Rice, Office of Research and Development, United States Environmental Protection Agency, Cincinnati, OH, USA also deserves thanks for his thoughtful feedback and inputs on the manuscript; William H.Goodson III was supported by the California Breast Cancer Research Program, Clarence Heller Foundation and California Pacific Medical Center Foundation; Abdul M.Ali would like to acknowledge the financial support of the University of Sultan Zainal Abidin, Malaysia; Ahmed Lasfar was supported by an award from the Rutgers Cancer Institute of New Jersey; Ann-Karin Olsen and Gunnar Brunborg were supported by the Research Council of Norway (RCN) through its Centres of Excellence funding scheme (223268/F50), Amancio Camaro's lab was supported by grants from the Spanish Ministry of Economy and Competitivity, ISCIII (Fis: PI12/00137, RTICC: RD12/0036/0028) co-funded by FEDER from Regional Development European Funds (European Union), Consejeria de Ciencia e Innovacion (CTS-1848) and Consejeria de Salud of the Junta de Andalucia (PI-0306-2012); Matilde E. Lleonart was supported by a trienal project grant PI12/01104 and by project CP03/00101 for personal support. Amaya Azqueta would like to thank the Ministerio de Educacion y Ciencia (Juande la Cierva' programme, 2009) of the Spanish Government for personal support; Amedeo Amedei was supported by the Italian Ministry of University and Research (2009FZZ4XM_002), and the University of Florence (ex60%2012); Andrew R.Collins was supported by the University of Oslo; Annamaria Colacci was supported by the Emilia-Romagna Region - Project 'Supersite' in Italy; Carolyn Baglole was supported by a salary award from the Fonds de recherche du Quebec-Sante (FRQ-S); Chiara Mondello's laboratory is supported by Fondazione Cariplo in Milan, Italy (grant n. 2011-0370); Christian C.Naus holds a Canada Research Chair; Clement Yedjou was supported by a grant from the National Institutes of Health (NIH-NIMHD grant no. G12MD007581); Daniel C.Koch is supported by the Burroughs Wellcome Fund Postdoctoral Enrichment Award and the Timor Biology Training grant: NIH T32CA09151; Dean W. Felsher would like to acknowledge the support of United States Department of Health and Human Services, NIH grants (R01 CA170378 PQ22, RO1 CA184384, U54 CA149145, U54 CA151459, P50 CA114747 and 1121 CA169964); Emilio Rojas would like to thank CONACyT support 152473; Ezio Laconi was supported by AIRC (Italian Association for Cancer Research, grant no. IG 14640) and by the Sardinian Regional Government (RAS); Eun-Yi Moon was supported by grants from the Public Problem-Solving Program (NRF-015M3C8A6A06014500) and Nuclear R&D Program (#2013M2B2A9A03051296 and 2010-0018545) through the National Research Foundation of Korea (NRF) and funded by the Ministry of Education, Science and Technology (MEST) in Korea; Fahd Al-Mulla was supported by the Kuwait Foundation for the Advancement of Sciences (2011-1302-06); Ferdinando Chiaradonna is supported by SysBioNet, a grant for the Italian Roadmap of European Strategy Forum on Research Infrastructures (ESFRI) and by AIRC (Associazione Italiana Ricerca sul Cancro; IG 15364); Francis L.Martin acknowledges funding from Rosemere Cancer Foundation; he also thanks Lancashire Teaching Hospitals NHS trust and the patients who have facilitated the studies he has undertaken over the course of the last 10 years; Gary S.; Goldberg would like to acknowledge the support of the New Jersey Health Foundation; Gloria M.Calaf was supported by Fondo Nacional de Ciencia y Tecnologia (FONDECYT), Ministerio de Educacion de Chile (MINEDUC), Universidad de Tarapac6 (UTA); Gudrun Koppen was supported by the Flemish Institute for Technological Research (VITO), Belgium; Hemad Yasaei was supported from a triennial project grant (Strategic Award) from the National Centre for the Replacement, Refinement and Reduction (NC3Rs) of animals in research (NC.K500045.1 and G0800697); Hiroshi Kondoh was supported in part by grants from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, Japan Science and Technology Agency and by JST, CREST; Hsue-Yin Hsu was supported by the Ministry of Science and Technology of Taiwan (NSC93-2314-B-320-006 and NSC94-2314-B-320-002); Hyun Ho Park was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) of the Ministry of Education, Science and Technology (2012R1A2A2A01010870) and a grant from the Korea Healthcare Technology R&D project, Ministry of Health and Welfare, Republic of Korea (HI13C1449); Igor Koturbash is supported by the UAMS/NIH Clinical and Translational Science Award (UL1TR000039 and KL2TR000063) and the Arkansas Biosciences Institute, the major research component of the Arkansas Tobacco Settlement Proceeds Act of 2000; Jan VondrLek acknowledges funding from the Czech Science Foundation (13-07711S); Jesse Roman thanks the NIH for their support (CA116812); John Pierce Wise Sr. and Sandra S.Wise were supported by National Institute of Environmental Health Sciences (ES016893 to J.P.W.) and the Maine Center for Toxicology and Environmental Health; Jonathan Whitfield acknowledges support from the FERO Foundation in Barcelona, Spain; Joseph Christopher is funded by Cancer Research UK and the International Journal of Experimental Pathology; Julia Kravchenko is supported by a philanthropic donation by Fred and Alice Stanback; Jun Sun is supported by a Swim Across America Cancer Research Award; Karine A.Cohen-Solal is supported by a research scholar grant from the American Cancer Society (116683-RSG-09-087-01-TBE); Laetitia Gonzalez received a postdoctoral fellowship from the Fund for Scientific Research-Flanders (FWO-Vlaanderen) and support by an Inter University Attraction Pole grant (IAP-P7-07); Laura Soucek is supported by grant #CP10/00656 from the Miguel Servet Research Contract Program and acknowledges support from the FERO Foundation in Barcelona, Spain; Liang-Tzung Lin was supported by funding from the Taipei Medical University (TMU101-AE3-Y19); Linda Gulliver is supported by a Genesis Oncology Trust (NZ) Professional Development Grant, and the Faculty of Medicine, University of Otago, Dunedin, New Zealand; Louis Vermeulen is supported by a Fellowship of the Dutch Cancer Society (KWF, UVA2011-4969) and a grant from the AICR (14-1164); Mahara Valverde would like to thank CONACyT support 153781; Masoud H. Manjili was supported by the office of the Assistant Secretary of Defense for Health Affairs (USA) through the Breast Cancer Research Program under Award No. W81XWH-14-1-0087 Neetu Singh was supported by grant #SR/FT/LS-063/2008 from the Department of Science and Technology, Government of India; Nicole Kleinstreuer is supported by NIEHS contracts (N01-ES 35504 and HHSN27320140003C); P.K. Krishnakumar is supported by the Funding (No. T.K. 11-0629) of King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia; Paola A.; Marignani is supported by the Dalhousie Medical Research Foundation, The Beatrice Hunter Cancer Institute and CIHR and the Nova Scotia Lung Association; Paul Dent is the holder of the Universal Inc. Chair in Signal Transduction Research and is supported with funds from PHS grants from the NIH (R01-CA141704, R01-CA150214, R01-DK52825 and R01-CA61774); Petr Heneberg was supported by the Charles University in Prague projects UNCE 204015 and PRVOUK P31/2012, and by the Czech Science Foundation projects P301/12/1686 and 15-03834Y; Po Sing Leung was supported by the Health and Medical Research Fund of Food and Health Bureau, Hong Kong Special Administrative Region, Ref. No: 10110021; Qiang Cheng was supported in part by grant NSF IIS4218712; R. Brooks Robey is supported by the United States Department of Veterans Affairs; Rabindra Roy was supported by United States Public Health Service Grants (RO1 CA92306, RO1 CA92306-S1 and RO1 CA113447); Rafaela AndradeVieira is supported by the Beatrice Hunter Cancer Research Institute and the Nova Scotia Health Research Foundation; Renza Vento was partially funded by European Regional Development Fund, European Territorial Cooperation 2007-13 (CCI 2007 CB 163 PO 037, OP Italia-Malta 2007-13) and grants from the Italian Ministry of Education, University and Research (MIUR) ex-60%, 2007; Riccardo Di Fiore was a recipient of fellowship granted by European Regional Development Fund, European Territorial Cooperation 2007-2013 (CCI 2007 CB 163 PO 037, OP Italia-Malta 2007-2013); Rita Dornetshuber-Fleiss was supported by the Austrian Science Fund (FWF, project number T 451-B18) and the Johanna Mahlke, geb.-Obermann-Stiftung; Roberta Palorini is supported by a SysBioNet fellowship; Roslida Abd Hamid is supported by the Ministry of Education, Malaysia-Exploratory Research Grant Scheme-Project no: ERGS/1-2013/5527165; Sabine A.S.Langie is the beneficiary of a postdoctoral grant from the AXA Research Fund and the Cefic-LRI Innovative Science Award 2013; Sakina Eltom is supported by NIH grant SC1CA153326; Samira A. Brooks was supported by National Research Service Award (T32 ES007126) from the National Institute of Environmental Health Sciences and the HHMI Translational Medicine Fellowship; Sandra Ryeom was supported by The Garrett B. Smith Foundation and the TedDriven Foundation; Thierry Massfelder was supported by the Institut National de la Sante et de la Recherche Medicale INSERM and Universite de Strasbourg; Thomas Sanderson is supported by the Canadian Institutes of Health Research (CIHR; MOP115019), the Natural Sciences and Engineering Council of Canada (NSERC; 313313) and the California Breast Cancer Research Program (CBCRP; 17UB-8703); Tiziana Guarnieri is supported by a grant from Fundamental Oriented Research (RFO) to the Alma Mater Studiorum University of Bologna, Bologna, Italy and thanks the Fondazione Cassa di Risparmio di Bologna and the Fondazione Banca del Monte di Bologna e Ravenna for supporting the Center for Applied Biomedical Research, S.Orsola-Malpighi University Hospital, Bologna, Italy; W.Kimryn Rathmell is supported by the V Foundation for Cancer Research and the American Cancer Society; William K.Decker was supported in part by grant RP110545 from the Cancer Prevention Research Institute of Texas; William H.; Bisson was supported with funding from the NIH P30 ES000210; Yon Rojanasakul was supported with NIH grant R01-ES022968; Zhenbang Chen is supported by NIH grants (MD004038, CA163069 and MD007593); Zhiwei Hu is grateful for the grant support from an institutional start-up fund from The Ohio State University College of Medicine and The OSU James Comprehensive Cancer Center (OSUCCC) and a Seed Award from the OSUCCC Translational Therapeutics Program, NR 508 TC 34 Z9 36 U1 14 U2 73 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0143-3334 EI 1460-2180 J9 CARCINOGENESIS JI Carcinogenesis PD JUN PY 2015 VL 36 SU 1 BP S254 EP S296 DI 10.1093/carcin/bgv039 PG 43 WC Oncology SC Oncology GA CL6AQ UT WOS:000357048100013 PM 26106142 ER PT J AU Dagefu, FT Verma, G Rao, CR Yu, PL Fink, JR Sadler, BM Sarabandi, K AF Dagefu, Fikadu T. Verma, Gunjan Rao, Chirag R. Yu, Paul L. Fink, Jonathan R. Sadler, Brian M. Sarabandi, Kamal TI Short-Range Low-VHF Channel Characterization in Cluttered Environments SO IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION LA English DT Article DE Channel phase distortion; indoor/outdoor propagation measurements; lower VHF band; near-ground propagation; path loss; transfer function measurements; wireless channel characterization ID PATH-LOSS MODEL; COMMUNICATION-SYSTEMS; WAVE-PROPAGATION; RADIO AB The lower VHF band has potential for low-power, short-range communications, as well as for geolocation applications, in both indoor and urban environments. Most prior work at low VHF focuses on longer range path loss modeling, often with one node elevated. In this paper, we study indoor/outdoor near-ground scenarios through experiments and electromagnetic wave propagation simulations. These include the effects of indoor penetration through walls and obstacles, as well as indoor/outdoor cases, for both line of sight (LoS) and nonLoS (NLoS), at ranges up to 200 m. Mounting our receiver (Rx) on a robotic platform enabled the collection of thousands of measurements over an extended indoor/outdoor test area. We measure the channel transfer function, employing bandpass waveform sampling, with pulse and tone probe signals. Based on statistical tests, we show that the measured channels have a nearly ideal scalar attenuation and delay transfer function, with minimal phase distortion, and little to no evidence of multipath propagation. Compared with higher VHF and above, the measured short-range VHF channels do not exhibit small-scale fading, which simplifies communications Rx signal processing, and enables phase-based geolocation techniques. C1 [Dagefu, Fikadu T.; Verma, Gunjan; Rao, Chirag R.; Yu, Paul L.; Fink, Jonathan R.; Sadler, Brian M.] Army Res Lab, Adelphi, MD 20783 USA. [Sarabandi, Kamal] Univ Michigan, Dept Elect Engn & Comp Sci, Ann Arbor, MI 48109 USA. RP Dagefu, FT (reprint author), Army Res Lab, Adelphi, MD 20783 USA. EM fikadu.t.dagefu.ctr@mail.mil; gunjan.verma.civ@mail.mil; chirag.r.rao.civ@mail.mil; paul.l.yu.civ@mail.mil; jonathan.r.fink3.civ@mail.mil; brian.m.sadler6.civ@mail.mil; saraband@eecs.umich.edu NR 23 TC 4 Z9 4 U1 2 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-926X EI 1558-2221 J9 IEEE T ANTENN PROPAG JI IEEE Trans. Antennas Propag. PD JUN PY 2015 VL 63 IS 6 BP 2719 EP 2727 DI 10.1109/TAP.2015.2418346 PG 9 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA CM3SV UT WOS:000357605400032 ER PT J AU Jalah, R Torres, OB Mayorov, AV Li, FY Antoline, JFG Jacobson, AE Rice, KC Deschamps, JR Beck, Z Alving, CR Matyas, GR AF Jalah, Rashmi Torres, Oscar B. Mayorov, Alexander V. Li, Fuying Antoline, Joshua F. G. Jacobson, Arthur E. Rice, Kenner C. Deschamps, Jeffrey R. Beck, Zoltan Alving, Carl R. Matyas, Gary R. TI Efficacy, but Not Antibody Titer or Affinity, of a Heroin Hapten Conjugate Vaccine Correlates with Increasing Hapten Densities on Tetanus Toxoid, but Not on CRM197 Carriers SO BIOCONJUGATE CHEMISTRY LA English DT Article ID SUBSTANCE-ABUSE; GLYCOCONJUGATE VACCINES; MORPHINE/HEROIN VACCINE; PROTEIN; TOXIN; RATS; 6-MONOACETYLMORPHINE; IMMUNOGENICITY; DERIVATIVES; ADDICTION AB Vaccines against drugs of abuse have induced antibodies in animals that blocked the biological effects of the drug by sequestering the drug in the blood and preventing it from crossing the blood-brain barrier. Drugs of abuse are too small to induce antibodies and, therefore, require conjugation of drug hapten analogs to a carrier protein. The efficacy of these conjugate vaccines depends on several factors including hapten design, coupling strategy, hapten density, carrier protein selection, and vaccine adjuvant. Previously, we have shown that 1 (MorHap), a heroin/morphine hapten, conjugated to tetanus toxoid (TT) and mixed with liposomes containing monophosphoryl lipid A [L(MPLA)] as adjuvant, partially blocked the antinociceptive effects of heroin in mice. Herein, we extended those findings, demonstrating greatly improved vaccine induced antinociceptive effects up to 3% mean maximal potential effect (%MPE). This was obtained by evaluating the effects of vaccine efficacy of hapten 1 vaccine conjugates with varying hapten densities using two different commonly used carrier proteins, TT and cross-reactive material 197 (CRM197). Immunization of mice with these conjugates mixed with L(MPLA) induced very high anti-1 IgG peak levels of 400-1500 mu g/mL that bound to both heroin and its metabolites, 6-acetylmorphine and morphine. Except for the lowest hapten density for each carrier, the antibody titers and affinity were independent of hapten density. The TT carrier based vaccines induced long-lived inhibition of heroin-induced antinociception that correlated with increasing hapten density. The best formulation contained TT with the highest hapten density of >= 30 haptens/TT molecule and induced %MPE of approximately 3% after heroin challenge. In contrast, the best formulation using CRM197 was with intermediate 1 densities (10-15 haptens/CRM197 molecule), but the % MPE was approximately 13%. In addition, the chemical synthesis of 1, the optimization of the conjugation method, and the methods for the accurate quantification of hapten density are described. C1 [Jalah, Rashmi; Torres, Oscar B.; Mayorov, Alexander V.; Beck, Zoltan; Alving, Carl R.; Matyas, Gary R.] US Mil HIV Res Program, Lab Adjuvant & Antigen Res, Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Jalah, Rashmi; Torres, Oscar B.; Mayorov, Alexander V.] US Mil HIV Res Program, Henry M Jackson Fdn Adv Mil Med, Bethesda, MD 20817 USA. [Li, Fuying; Antoline, Joshua F. G.; Jacobson, Arthur E.; Rice, Kenner C.] NIDA, Drug Design & Synth Sect, Mol Targets & Medicat Discovery Branch, NIH,Dept Hlth & Human Serv, Bethesda, MD 20892 USA. [Li, Fuying; Antoline, Joshua F. G.; Jacobson, Arthur E.; Rice, Kenner C.] NIAAA, NIH, Bethesda, MD 20892 USA. [Deschamps, Jeffrey R.] Naval Res Lab, Ctr Biomol Sci & Engn, Washington, DC 20375 USA. RP Matyas, GR (reprint author), US Mil HIV Res Program, Lab Adjuvant & Antigen Res, Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM gmatyas@hivresearch.org RI Mayorov, Alexander/G-5204-2014; OI Mayorov, Alexander/0000-0002-0899-7138; Matyas, Gary/0000-0002-2074-2373 FU Henry M. Jackson Foundation for the Advancement of Military Medicine [W81XWH-07-2-067]; U.S. Army Medical Research and Materiel Command (MRMC) [W81XWH-07-2-067]; National Institute on Drug Abuse (NIH) [1DP1DA034787-01]; NIH Intramural Research Programs of the National Institute on Drug Abuse; National Institute of Alcohol Abuse and Alcoholism, NIH, DHHS; NIDA [Y1-DA1101]; Naval Research Laboratory (NRL) FX This work was supported through a Cooperative Agreement Award (no. W81XWH-07-2-067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine and the U.S. Army Medical Research and Materiel Command (MRMC). The work was partially supported by an Avant Garde award to GRM from the National Institute on Drug Abuse (NIH grant no. 1DP1DA034787-01). The work of FL, JFGA, AEJ, and KCR was supported by the NIH Intramural Research Programs of the National Institute on Drug Abuse and the National Institute of Alcohol Abuse and Alcoholism, NIH, DHHS. The X-ray crystallographic work was supported by NIDA through an Interagency Agreement #Y1-DA1101 with the Naval Research Laboratory (NRL). The authors thank Drs. Klaus Gawrisch and Walter Teague (Laboratory of Membrane Biochemistry and Biophysics, NIAAA), for NMR spectral data; and Noel Whittaker (Mass Spectrometry Facility, NIDDK) for mass spectral data. The authors also thank Mr. Marcus Gallon, Ms. Elaine Morrison, Ms. Courtney Tucker, and Ms. Caroline Kittinger for providing outstanding technical assistance. Research was conducted in compliance with the Animal Welfare Act and other federal statutes and regulations relating to animals and experiments involving animals and adhered to principles stated in the Guide for the Care and Use of Laboratory Animals, NRC Publication, 1996 edition. The views expressed in this article are those of the authors and do not necessarily reflect the official policy of the Department of the Army, Department of Defense, or NIH, or the U.S. Government. NR 49 TC 5 Z9 5 U1 2 U2 19 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1043-1802 J9 BIOCONJUGATE CHEM JI Bioconjugate Chem. PD JUN PY 2015 VL 26 IS 6 BP 1041 EP 1053 DI 10.1021/acs.bioconjchem.5b00085 PG 13 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Chemistry, Multidisciplinary; Chemistry, Organic SC Biochemistry & Molecular Biology; Chemistry GA CL2DS UT WOS:000356754400011 PM 25970207 ER PT J AU Kasten, SA Thayer, A AF Kasten, Shane A. Thayer, Angie TI Chiral SFC Separation of Chemical Warfare Nerve Agents Using the Whelk-O (R) 1 Chiral Stationary Phase SO LC GC NORTH AMERICA LA English DT Editorial Material C1 [Kasten, Shane A.] US Army, Med Res Inst Chem Def, APG, Physiol & Immunol Branch,Res Div, Aberdeen Proving Ground, MD 21010 USA. [Thayer, Angie] Regis Technol Inc, Grove, IL 60053 USA. RP Kasten, SA (reprint author), US Army, Med Res Inst Chem Def, APG, Physiol & Immunol Branch,Res Div, Aberdeen Proving Ground, MD 21010 USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU ADVANSTAR COMMUNICATIONS INC PI DULUTH PA 131 W 1ST STREET, DULUTH, MN 55802 USA SN 1527-5949 EI 1939-1889 J9 LC GC N AM JI LC GC N. AM. PD JUN PY 2015 SU S BP 13 EP 13 PG 1 WC Chemistry, Analytical SC Chemistry GA CL3IT UT WOS:000356844300004 ER PT J AU Zaccaro, SJ Connelly, S Repchick, KM Daza, AI Young, MC Kilcullen, RN Gilrane, VL Robbins, JM Bartholomew, LN AF Zaccaro, Stephen J. Connelly, Shane Repchick, Kristin M. Daza, Andreina I. Young, Mark C. Kilcullen, Robert N. Gilrane, Veronica L. Robbins, Jordan M. Bartholomew, Lindsey N. TI The influence of higher order cognitive capacities on leader organizational continuance and retention: The mediating role of developmental experiences SO LEADERSHIP QUARTERLY LA English DT Article DE Leader retention; Leader turnover; Problem solving skills; Developmental experiences ID POSITION ANALYSIS QUESTIONNAIRE; PERCEIVED SUPERVISOR SUPPORT; EMPLOYEE TURNOVER; VOLUNTARY TURNOVER; PERSONALITY CONSTRUCTS; INCREMENTAL VALIDITY; INTEGRATED MODEL; JOB-PERFORMANCE; MODERATING ROLE; METAANALYSIS AB The relationship between cognitive capacities and retention or turnover has received scant attention in the extant literature. The few findings that have been reported show mixed to no linear effects of general mental ability on organizational continuance. In this study, we examined the association of more specific higher order cognitive capacities including complex problem solving skills and divergent thinking with officer continuance in the U.S. Army. We also tested the role of developmental experiences as a partial mediator of this relationship. Our sample included 640 officers who completed measures of these skills and of their career experiences in 1992-1993. To this sample, we added years of service from date of commissioning to 2008, as well as data on whether officers experienced particular assignments considered to be challenging and developmental. Our findings support the association of complex problem solving and divergent thinking skills with leader continuance. We also found that this effect is partially mediated by challenging developmental experiences. Thus, we provide stronger evidence than in prior studies for a linear relationship between cognitive abilities and continuance in an organization. (C) 2015 Elsevier Inc. All rights reserved. C1 [Zaccaro, Stephen J.; Repchick, Kristin M.; Daza, Andreina I.; Gilrane, Veronica L.; Robbins, Jordan M.; Bartholomew, Lindsey N.] Consortium Univ, Washington, DC USA. [Zaccaro, Stephen J.; Repchick, Kristin M.; Daza, Andreina I.; Gilrane, Veronica L.; Robbins, Jordan M.; Bartholomew, Lindsey N.] George Mason Univ, Fairfax, VA 22030 USA. [Connelly, Shane] Univ Oklahoma, Norman, OK 73019 USA. [Young, Mark C.; Kilcullen, Robert N.] US Army Res Inst Behav & Social Sci, Arlington, VA USA. RP Zaccaro, SJ (reprint author), George Mason Univ, Dept Psychol, MSN 3F5, Fairfax, VA 22030 USA. FU [W5J9CQ-11-C-0040]; [W5J9CQ-13-C-0004] FX Stephen J. Zaccaro, a professor of Psychology at George Mason University, and Shane Connelly, a professor of Psychology at the University of Oklahoma completed this research as Senior Fellows with the Consortium of Universities in Washington DC. Kristin M. Repchick, Andreina I. Daza, Veronica L. Gilrane, Jordan M. Robbins and Lindsey N. Bartholomew, as psychology graduate students at George Mason University completed this research as Junior Fellows with the Consortium of Universities. This research was fully funded and conducted under contracts W5J9CQ-11-C-0040 and W5J9CQ-13-C-0004 for the U.S. Army Research Institute for the Behavioral and Social Sciences (ARI). The views, opinions, and findings contained in this article are solely those of the authors and should not be construed as an official U.S. Department of the Army or U.S. Department of Defense position, policy, or decision, unless so designated by other documentation. Portions of this paper appeared in an API technical report and were also presented at the 121st annual meeting of the American Psychological Association, Honolulu, 2013. The authors wish to thank Winnie Young and Michael Ingerick for their work in constructing and documenting the very large and complex database used in this research. This article is not subject to copyright protection in the United States. NR 91 TC 1 Z9 1 U1 2 U2 13 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1048-9843 EI 1873-3409 J9 LEADERSHIP QUART JI Leadersh. Q. PD JUN PY 2015 VL 26 IS 3 SI SI BP 342 EP 358 DI 10.1016/j.leaqua.2015.03.007 PG 17 WC Psychology, Applied; Management SC Psychology; Business & Economics GA CL3HR UT WOS:000356841500004 ER PT J AU Ford, DD Lenahan, S Jorgensen, M Dube, P Delude, M Concannon, PE Anderson, SR Oyler, KD Cheng, G Mehta, N Salan, JS AF Ford, David D. Lenahan, Shannon Joergensen, Matthew Dube, Pascal Delude, Mark Concannon, Paul E. Anderson, Stephen R. Oyler, Karl D. Cheng, Gartung Mehta, Neha Salan, Jerry S. TI Development of a Lean Process to the Lead-Free Primary Explosive DBX-1 SO ORGANIC PROCESS RESEARCH & DEVELOPMENT LA English DT Article ID PERCHLORATE AB Copper(I) 5-nitrotetrazolate (DBX-1) has emerged in recent years as a primary explosive that could serve as a replacement for lead azide (LA), a widely used explosive that has fallen out of favor due to its toxicity and chemical compatibility issues. While there is a significant amount of interest in this material, the development of DBX-1 has been hampered by the tedious and poorly understood chemical process for its preparation. To consistently produce DBX-1, two explosive intermediates must be isolated, and one of them requires purification. In this article, we present an improved process for the synthesis of DBX-1. In this process, neither of these intermediates needs to be handled by an operator, and the purification step is no longer necessary. It would be practical to perform the entire process under remote control, a necessity for energetic material manufacturing. We discuss the implications of our findings for the development of a robust process for the reproducible production of high-quality DBX-1. C1 [Ford, David D.; Lenahan, Shannon; Joergensen, Matthew; Dube, Pascal; Delude, Mark; Concannon, Paul E.; Anderson, Stephen R.; Salan, Jerry S.] Nalas Engn Serv Inc, Centerbook, CT 06409 USA. [Oyler, Karl D.; Cheng, Gartung; Mehta, Neha] US Army, Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07885 USA. RP Mehta, N (reprint author), US Army, Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07885 USA. EM neha.mehta.civ@mail.mil; jerry.salan@nalasengineering.com FU U.S. Army RDECOM Environmental Acquisition and Logistics Sustainment Program (Environmental Quality Technology Pollution Prevention) FX The authors would like to thank the U.S. Army RDECOM Environmental Acquisition and Logistics Sustainment Program (Environmental Quality Technology Pollution Prevention) for supporting this program. NR 23 TC 3 Z9 3 U1 0 U2 8 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1083-6160 EI 1520-586X J9 ORG PROCESS RES DEV JI Org. Process Res. Dev. PD JUN PY 2015 VL 19 IS 6 BP 673 EP 680 DI 10.1021/acs.oprd.5b00107 PG 8 WC Chemistry, Applied; Chemistry, Organic SC Chemistry GA CL3IW UT WOS:000356844600010 ER PT J AU Duy, J Smith, RL Collins, SD Connell, LB AF Duy, Janice Smith, Rosemary L. Collins, Scott D. Connell, Laurie B. TI Rapid Colorimetric Detection of the Fungal Phytopathogen Synchytrium endobioticum Using Cyanine dye-Indicated PNA Hybridization SO AMERICAN JOURNAL OF POTATO RESEARCH LA English DT Article DE Potato wart fungus; Peptide nucleic acid; qPCR ID 16S RIBOSOMAL-RNA; PEPTIDE NUCLEIC-ACIDS; POTATO WART DISEASE; OLIGONUCLEOTIDE PROBES; CAUSAL AGENT; DNA; MICROARRAYS; SEQUENCE; ASSAY; SOIL AB Synchytrium endobioticum is a parasitic fungus that is considered to be the most important potato pathogen worldwide. Spread of the fungus can result in catastrophic impacts to agriculture and economy, as it is very infective and can survive in spore form for over 70 years. To date, the gold standard for S. endobioticum identification relies on visual classification by highly trained personnel. This paper presents the colorimetric detection of S. endobioticum from potato wart samples using a peptide nucleic acid (PNA) probe and a cyanine dye. A segment of the 18S ribosomal RNA gene was sequenced for several S. endobioticum pathotypes and used to design a species-specific PNA probe. The probe was used in a rapid colorimetric hybridization assay that detected RNA from infected wart tissue down to 10(-17) mol within 15 min. This technique demonstrates potential for rapid identification of potato wart in non-laboratory settings with minimally trained staff. C1 [Duy, Janice; Smith, Rosemary L.; Collins, Scott D.; Connell, Laurie B.] Univ Maine, ESRB LASST, Grad Sch Biomed Sci & Engn, Orono, ME 04469 USA. [Duy, Janice] US Army, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Smith, Rosemary L.] Univ Maine, Elect & Comp Engn Dept, Orono, ME 04469 USA. [Collins, Scott D.] Univ Maine, Dept Chem, Orono, ME 04469 USA. [Connell, Laurie B.] Univ Maine, Sch Marine Sci, Orono, ME 04469 USA. [Connell, Laurie B.] Univ Maine, Dept Mol & Biomed Sci, Orono, ME 04469 USA. RP Duy, J (reprint author), US Army, Med Res Inst Infect Dis, 1425 Porter St Ft Detrick, Frederick, MD 21702 USA. EM janice.duy@umit.maine.edu RI Smith, Rosemary/H-7359-2015; Collins, Scott/A-5806-2016 OI Smith, Rosemary/0000-0001-8483-6777; Collins, Scott/0000-0003-0204-5109 NR 53 TC 1 Z9 1 U1 2 U2 13 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1099-209X EI 1874-9380 J9 AM J POTATO RES JI Am. J. Potato Res. PD JUN PY 2015 VL 92 IS 3 BP 398 EP 409 DI 10.1007/s12230-015-9450-z PG 12 WC Agronomy SC Agriculture GA CK6KT UT WOS:000356337700011 ER PT J AU Bricker, JD Gibson, S Takagi, H Imamura, F AF Bricker, Jeremy D. Gibson, Stanford Takagi, Hiroshi Imamura, Fumihiko TI On the Need for Larger Manning's Roughness Coefficients in Depth-Integrated Tsunami Inundation Models SO COASTAL ENGINEERING JOURNAL LA English DT Article DE Tsunami inundation model; Manning's n; land-use; roughness; friction ID VEGETATION ROUGHNESS; COASTAL FOREST; WAVES; RIVER; PROPAGATION; HYDRAULICS; SIMULATION; FLOW AB Manning's n values for open channel (river) flow have been studied by hydraulic engineers since the late 19th century, and a rich literature exists on the topic including large-scale laboratory experiments and actual field measurements. Both river flood models and shallow water equation tsunami inundation models incorporate the importance of varying equivalent roughness values with the large-scale roughness elements present for different land use types. However, many tsunami models (especially in Japan) use n values based on a very limited set of small-scale model laboratory experiments with inappropriate Reynolds and Weber numbers, instead of using Manning's n values from the open channel flow literature. Due to this, equivalent Manning's n values for vegetated and urban areas in these tsunami inundation models are too small, causing the mitigating effect of forests and urban regions to be underestimated. This paper presents a review of Manning's n research applied to both river flood and tsunami inundation models, and suggests values to improve the reliability of the latter. C1 [Bricker, Jeremy D.; Imamura, Fumihiko] Tohoku Univ, Int Res Inst Disaster Sci, Aoba Ku, Sendai, Miyagi 9800845, Japan. [Gibson, Stanford] US Army, Corps Engineers, Hydrol Engn Ctr, Davis, CA 95616 USA. [Takagi, Hiroshi] Tokyo Inst Technol, Dept Int Dev Engn, Meguro Ku, Tokyo 1528550, Japan. RP Bricker, JD (reprint author), Tohoku Univ, Int Res Inst Disaster Sci, Aoba Ku, 468-1-E304 Aoba, Sendai, Miyagi 9800845, Japan. EM bricker@irides.tohoku.ac.jp; Stanford.Gibson@usace.army.mil; takagi@ide.titech.ac.jp; imamura@irides.tohoku.ac.jp RI Takagi, Hiroshi/B-4566-2017 OI Takagi, Hiroshi/0000-0002-3668-688X FU International Research Institute of Disaster Science (IRIDeS) Tokutei Project Grant for International Collaboration; JSPS-NSF Cooperative Program for Interdisciplinary Joint Research Projects in Hazards and Disasters FX Discussions with the participants of the International Workshop on the Application of Fluid Mechanics to Disaster Reduction (AFMDR) were essential to this paper. In addition to the authors, these participants included Akihiko Nakayama, Akira Mano, Edward Gross, Kwok Fai Cheung, Yoshiaki Kuriyama, Lisa Andes, Solomon Yim, Gary Chock, Jun Mitsui, Koji Kawasaki, Tadaru Ishikawa and Mathew Francis. Celso Ferreira, Scott Stonestreet, Ingrid Charvet, Volker Roeber, Nguyen Xuan Dao and Erick Mas also provided insightful ideas. The AFMDR workshop was funded by an International Research Institute of Disaster Science (IRIDeS) Tokutei Project Grant for International Collaboration. The JSPS-NSF Cooperative Program for Interdisciplinary Joint Research Projects in Hazards and Disasters, project entitled "Evolution of Urban Regions in Response to Recurring Disasters", also supported the workshop. Workshop content is posted online at http://hydraulic.lab.irides.tohoku.ac.jp/app-def/S-102/2014/?page_id=15. NR 64 TC 5 Z9 5 U1 6 U2 21 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE SN 0578-5634 EI 1793-6292 J9 COAST ENG J JI Coast Eng. J. PD JUN PY 2015 VL 57 IS 2 AR 1550005 DI 10.1142/S0578563415500059 PG 13 WC Engineering, Civil; Engineering, Ocean SC Engineering GA CK8XE UT WOS:000356522600005 ER PT J AU Wirtz, ED Hoshino, D Maldonado, AT Tyson, DR Weaver, AM AF Wirtz, Eric D. Hoshino, Daisuke Maldonado, Anthony T. Tyson, Darren R. Weaver, Alissa M. TI Response of Head and Neck Squamous Cell Carcinoma Cells Carrying PIK3CA Mutations to Selected Targeted Therapies SO JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY LA English DT Article ID ONCOGENE ADDICTION; DRUG-SENSITIVITY; NODE METASTASIS; CANCER-CELLS AB IMPORTANCE The PIK3CA mutation is one of the most common mutations in head and neck squamous cell carcinoma (HNSCC). Through this research we attempt to elicit the role of oncogene dependence and effects of targeted therapy on this PIK3CA mutation. OBJECTIVES (1) To determine the role of oncogene dependence on PIK3CA-one of the more common and targetable oncogenes in HNSCC, and (2) to evaluate the consequence of this oncogene on the effectiveness of newly developed targeted therapies. DESIGN, SETTING, AND PARTICIPANTS This was a cell culture-based, in vitro study performed at an academic research laboratory assessing the viability of PIK3CA-mutated head and neck cell lines when treated with targeted therapy. EXPOSURES PIK3CA-mutated head and neck cell lines were treated with 17-AAG, GDC-0941, trametinib, and BEZ-235. MAIN OUTCOMES AND MEASURES Assessment of cell viability of HNSCC cell lines characterized for PIK3CA mutations or SCC25 cells engineered to express the PIK3CA hotspot mutations E545K or H1047R RESULTS Surprisingly, in engineered cell lines, the hotspot E545K and H1047R mutations conferred increased, rather than reduced, IC50 assay measurements when treated with the respective HSP90, PI3K, and MEK inhibitors, 17-AAG, GDC-0941, and trametinib, compared with the SCC25 control cell lines. When treated with BEZ-235, H1047R-expressing cell lines showed increased sensitivity to inhibition compared with control, whereas those expressing E545K showed slightly increased sensitivity of unclear significance. CONCLUSIONS AND RELEVANCE (1) The PIK3CA mutations within our engineered cell model did not lead to enhanced oncogene-dependent cell death when treated with direct inhibition of the PI3K enzyme yet did show increased sensitivity compared with control with dual PI3K/mTOR inhibition. (2) Oncogene addiction to PIK3CA hotspot mutations, if it occurs, is likely to evolve in vivo in the context of additional molecular changes that remain to be identified. Additional study is required to develop new model systems and approaches to determine the role of targeted therapy in the treatment of PI3K-overactive HNSCC tumors. C1 [Wirtz, Eric D.] Tripler Army Med Ctr, Dept Otolaryngol Head & Neck Surg, Honolulu, HI 96859 USA. [Hoshino, Daisuke] Kanagawa Canc Ctr, Div Canc Cell Res, Yokohama, Kanagawa 2410815, Japan. [Maldonado, Anthony T.; Tyson, Darren R.; Weaver, Alissa M.] Vanderbilt Univ, Med Ctr, Dept Canc Biol, Nashville, TN 37232 USA. RP Weaver, AM (reprint author), Vanderbilt Univ, Med Ctr, Dept Canc Biol, 2220 Pierce Ave,Preston Res Bldg,Room 748, Nashville, TN 37232 USA. EM alissa.weaver@vanderbilt.edu OI Tyson, Darren/0000-0002-3272-4308 FU National Institutes of Health-National Cancer Institute grant [R01-CA163592]; Robert J. Kleberg Jr and Helen C. Kleberg Foundation via the Vanderbilt-Ingram Cancer Center FX Funding was provided by National Institutes of Health-National Cancer Institute grant R01-CA163592 to A.M.W. and Pilot funding from the Robert J. Kleberg Jr and Helen C. Kleberg Foundation via the Vanderbilt-Ingram Cancer Center to E.D.W. and A.M.W. NR 18 TC 2 Z9 2 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6181 EI 2168-619X J9 JAMA OTOLARYNGOL JI JAMA Otolaryngol-Head Neck Surg. PD JUN PY 2015 VL 141 IS 6 BP 543 EP 549 DI 10.1001/jamaoto.2015.0471 PG 7 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA CK8AC UT WOS:000356458300009 PM 25855885 ER PT J AU Amberg, JJ McCalla, SG Monroe, E Lance, R Baerwaldt, K Gaikowski, MP AF Amberg, Jon J. McCalla, S. Grace Monroe, Emy Lance, Richard Baerwaldt, Kelly Gaikowski, Mark P. TI Improving efficiency and reliability of environmental DNA analysis for silver carp SO JOURNAL OF GREAT LAKES RESEARCH LA English DT Article DE eDNA; Asian carp; Invasive species; Bighead carp; Silver carp ID WATER SAMPLES; EXTRACTION; ABUNDANCE; KITS; PCR AB Natural resource agencies have established surveillance programs which use environmental DNA (eDNA) for the early detection of bighead carp Hypophthalmichthys nobilis and silver carp Hypophthalmichthys molitrix before they establish populations within the Great Lakes. This molecular monitoring technique must be highly accurate and precise for confident interpretation and also efficient, both in detection threshold and cost. Therefore, we compared two DNA extraction techniques and compared a new quantitative PCR (qPCR) assay with the conventional PCR (cPCR) assay used by monitoring programs. Both the qPCR and cPCR assays were able to amplify the DNA of silver carp present in environmental samples taken from locations where mixed populations of bigheaded carps existed. However, the qPCR assay had substantially fewer PCR positive samples which were subsequently determined not to contain DNA of bigheaded carps than the cPCR assay. Additionally, the qPCR assay was able to amplify the DNA of bigheaded carps even in the presence of inhibitors that blocked amplification with cPCR. Also, the selection of an appropriate DNA extraction method can significantly alter the efficiency of eDNA surveillance programs by lowering detection limits and by decreasing costs associated with sample processing. The results reported herein are presently being incorporated into eDNA surveillance programs to decrease the costs, increase DNA yield and increase the confidence that assays are amplifying the target DNA. These results are critical to enhancing our ability to accurately and confidently interpret the results reported from monitoring programs using eDNA for early detection of invasive species. Published by Elsevier B.V. on behalf of International Association for Great Lakes Research. C1 [Amberg, Jon J.; McCalla, S. Grace; Gaikowski, Mark P.] US Geol Survey, Upper Midwest Environm Sci Ctr, La Crosse, WI 54603 USA. [Monroe, Emy] US Fish & Wildlife Serv Resource Ctr, Whitney Genet Lab, Onalaska, WI 54650 USA. [Lance, Richard] US Army Corps Engineers, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Baerwaldt, Kelly] US Army Corps Engineers, Rock Isl, IL 61204 USA. RP Amberg, JJ (reprint author), US Geol Survey, Upper Midwest Environm Sci Ctr, 2630 Fanta Reed Rd, La Crosse, WI 54603 USA. EM jamberg@usgs.gov OI McCalla, S. Grace/0000-0003-4292-8694; Gaikowski, Mark/0000-0002-6507-9341 FU Great Lakes Restoration Initiative [DW14958229010] FX This project was funded through the Great Lakes Restoration Initiative (DW14958229010) and was part of the Environmental DNA Calibration Study managed by the U.S. Army Corps of Engineers. The authors thank Dr. Peter Sorensen and staff of the University of Minnesota, Dr. Loren Miller and staff of Minnesota Department of Natural Resources, Byron Karns of the National Park Service and James Lamer of Western Illinois University for collecting and processing water samples from Square Lake and below Lock and Dan 19 on the Mississippi River. The authors also thank the staffs of the molecular laboratory of the USGS Upper Midwest Environmental Sciences Center, USFWS Whitney Genetics Laboratory, and the Environmental Laboratory at the US Army Engineer Research and Development Center for helping to collect, process and analyze samples. NR 34 TC 6 Z9 6 U1 10 U2 64 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0380-1330 J9 J GREAT LAKES RES JI J. Gt. Lakes Res. PD JUN PY 2015 VL 41 IS 2 BP 367 EP 373 DI 10.1016/j.jglr.2015.02.009 PG 7 WC Environmental Sciences; Limnology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA CK7GE UT WOS:000356400000007 ER PT J AU Baskaran, M Miller, CJ Kumar, A Andersen, E Hui, J Selegean, JP Creech, CT Barkach, J AF Baskaran, M. Miller, C. J. Kumar, A. Andersen, E. Hui, J. Selegean, J. P. Creech, C. T. Barkach, J. TI Sediment accumulation rates and sediment dynamics using five different methods in a well-constrained impoundment: Case study from Union Lake, Michigan SO JOURNAL OF GREAT LAKES RESEARCH LA English DT Article DE Reservoir sedimentation; Pb-210 dating; Sediment retention; Cs-137 dating ID PB-210; CS-137; WATER; TRANSPORT; GEOCHRONOLOGIES; MOBILIZATION; RADIOCESIUM; CESIUM-137; CHRONOLOGY; PROFILES AB The single most important factor affecting the longevity of US dams is sedimentation, reducing and perhaps eliminating the reservoir capacity for future sediment storage and flood wave attenuation. A better understanding of the sedimentation rates and sediment dynamics is required for a better management of these dams. Towards this, we collected and analyzed 7 sediment cores from Union Lake for excess Pb-210 and Cs-132 to determine the sediment accumulation rates (Pb-210(xs)-based: 0.12 to 0.28 g cm(-2) y(-1); peak Cs-137-based: 0.13 to 0.29 g cm(-2) y(-1)). These average sediment accumulation rates obtained using radionuclides are compared with three other methods: i) bathymetry-based, from the cumulative mass depth of the core and age of the impoundment (0.09 to 0.26 g cm(-2) y(-1)); ii) sediment-yield curve obtained for 61 other watersheds (1.2 g cm(-2) y(-1)); and iii) gage data of sediment discharge (0.21 g cm(-2) y(-1)). Such a comparison provides insight on refining the sediment-yield curve-based sediment loading in the impoundment. Vertical profiles of Cs-132 provide not only insight on sediment mixing (based on a novel method by analyzing the Gaussian-like curve), but also the effectiveness of vibra-coring method in retrieving the full length of the soft sediment deposited since the construction of the dam. The present investigation can serve as a model study for application to other dams in the Great Lakes region and has implications to larges lakes in the Great Lakes catchment for the prediction of sediment accumulation rates using a variety of methods. (C) 2015 International Association for Great Lakes Research. Published by Elsevier B.V. All rights reserved. C1 [Baskaran, M.; Kumar, A.] Wayne State Univ, Dept Geol, Detroit, MI 48202 USA. [Miller, C. J.; Andersen, E.; Hui, J.] Wayne State Univ, Dept Civil & Environm Engn, Detroit, MI 48202 USA. [Selegean, J. P.; Creech, C. T.] US Army Corps Engineers, Detroit, MI 48226 USA. [Barkach, J.] Great Lakes Environm Ctr Inc, Farmington Hills, MI 48334 USA. RP Baskaran, M (reprint author), Wayne State Univ, Dept Geol, Detroit, MI 48202 USA. EM Baskaran@wayne.edu OI Baskaran, Mark/0000-0002-2218-4328 FU U.S. Army Corps of Engineers [W911XK-10-C-0011, W911X1C-14-C-0023] FX We thank a large number of people who assisted with various aspects of this project that include Pranesh Jayakumar and a large number of undergraduate students. We thank Editor-in-Chief Robert Hecky for providing insights on the relevance of this study to larger lakes. This project was funded by the U.S. Army Corps of Engineers (W911XK-10-C-0011 and W911X1C-14-C-0023). NR 37 TC 2 Z9 2 U1 0 U2 13 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0380-1330 J9 J GREAT LAKES RES JI J. Gt. Lakes Res. PD JUN PY 2015 VL 41 IS 2 BP 607 EP 617 DI 10.1016/j.jglr.2015.03.013 PG 11 WC Environmental Sciences; Limnology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA CK7GE UT WOS:000356400000032 ER PT J AU Elder, RM Pfaendtner, J Jayaraman, A AF Elder, Robert M. Pfaendtner, Jim Jayaraman, Arthi TI Effect of Hydrophobic and Hydrophilic Surfaces on the Stability of Double-Stranded DNA SO BIOMACROMOLECULES LA English DT Article AB DNA hybridization is the foundation for numerous technologies like DNA origami and DNA sensing/microarrays. Using molecular simulations, enhanced-sampling methods, and free-energy calculations, we show the effects of hydrophilic and hydrophobic surfaces on DNA hybridization. Hydrophilic surfaces compete with terminal bases' H-bonds but stabilize central base stacking. Hydrophobic surfaces strengthen terminal H-bonds but destabilize central base,stacking. Regardless of surface chemistry, for terminal bases, melting proceeds through breaking H-bonds, followed by unstacking from-the neighboring base. For central bases in bulk or near hydrophobic surfaces, melting proceeds by disruption of H-bonds, followed by unstacking, whereas on hydrophilic Surfaces, unstacking from one neighboring base precedes complete disruption of the H-bonds, followed by unstacking from the second neighboring base. Kinetic barriers to melting and hybridization show that the central bases melt rapidly near hydrophobic surfaces, Which can accelerate conformational searching and thereby accelerate folding into the desired conformation. C1 [Elder, Robert M.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Elder, Robert M.; Jayaraman, Arthi] Univ Colorado, Dept Chem & Biol Engn, Boulder, CO 80309 USA. [Pfaendtner, Jim] Univ Washington, Dept Chem Engn, Seattle, WA 98195 USA. [Jayaraman, Arthi] Univ Delaware, Dept Chem & Biomol Engn, Newark, DE 19716 USA. [Jayaraman, Arthi] Univ Delaware, Dept Mat Sci & Engn, Newark, DE 19716 USA. RP Elder, RM (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM robert.elder26.ctr@mail.mil; arthij@udel.edu RI Elder, Robert/H-9886-2016 FU NSF [CBET-1264459, CNS-0821794]; NSF DMR Biomaterials Grant [DMR-1206894]; XSEDE [TG-MCB100140]; University of Colorado Boulder FX R.M.E. was supported by an appointment to the Postgraduate Research Participation Program at the U.S. Army Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USARL. J.P. acknowledges financial support from NSF award CBET-1264459. R.M.E and A.J. acknowledge financial support from NSF DMR Biomaterials Grant DMR-1206894 and supercomputing time through XSEDE (TG-MCB100140). This work used the Janus supercomputer, which is supported by the NSF (CNS-0821794) and University of Colorado Boulder. A.J. thanks J.J. de Pablo for useful scientific comments. NR 77 TC 7 Z9 7 U1 9 U2 32 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1525-7797 EI 1526-4602 J9 BIOMACROMOLECULES JI Biomacromolecules PD JUN PY 2015 VL 16 IS 6 BP 1862 EP 1869 DI 10.1021/acs.biomac.5b00469 PG 8 WC Biochemistry & Molecular Biology; Chemistry, Organic; Polymer Science SC Biochemistry & Molecular Biology; Chemistry; Polymer Science GA V39IY UT WOS:000209405900020 PM 25961882 ER PT J AU Swiss, TP Ruhl, DS Roofe, SB AF Swiss, Tyler P. Ruhl, Douglas S. Roofe, Scott B. TI Neuropathic pain from a nasal valve suspension suture SO ENT-EAR NOSE & THROAT JOURNAL LA English DT Editorial Material C1 [Swiss, Tyler P.; Ruhl, Douglas S.; Roofe, Scott B.] Tripler Army Med Ctr, Otolaryngol Head & Neck Surg Serv, Honolulu, HI 96859 USA. [Roofe, Scott B.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Swiss, TP (reprint author), Tripler Army Med Ctr, Otolaryngol Head & Neck Surg Serv, Honolulu, HI 96859 USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU VENDOME GROUP LLC PI NEW YORK PA 6 EAST 32 ST, 8 FLOOR, NEW YORK, NY 10016 USA SN 0145-5613 EI 1942-7522 J9 ENT-EAR NOSE THROAT JI ENT-Ear Nose Throat J. PD JUN PY 2015 VL 94 IS 6 BP 216 EP + PG 2 WC Otorhinolaryngology SC Otorhinolaryngology GA CK1IR UT WOS:000355961500005 PM 26053978 ER PT J AU Menning, B AF Menning, Bruce TI Russian Military Intelligence, July 1914: What St. Petersburg Perceived and Why It Mattered SO HISTORIAN LA English DT Article ID WAR C1 [Menning, Bruce] Univ Kansas, Hist & Russian & East European Studies, Lawrence, KS 66045 USA. [Menning, Bruce] US Army Command, Ft Leavenworth, KS USA. [Menning, Bruce] Gen Staff Coll, Ft Leavenworth, KS USA. RP Menning, B (reprint author), Univ Kansas, Hist & Russian & East European Studies, Lawrence, KS 66045 USA. NR 182 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0018-2370 EI 1540-6563 J9 HISTORIAN JI Historian PD SUM PY 2015 VL 77 IS 2 BP 213 EP 268 DI 10.1111/hisn.12065 PG 56 WC History SC History GA CK0FM UT WOS:000355880900002 ER PT J AU Yu, PL Verma, G Sadler, BM AF Yu, Paul L. Verma, Gunjan Sadler, Brian M. TI Wireless Physical Layer Authentication via Fingerprint Embedding SO IEEE COMMUNICATIONS MAGAZINE LA English DT Article AB Authentication is a fundamental requirement for secure communications. In this article, we describe a general framework for fingerprint embedding at the physical layer in order to provide message authentication that is secure and bandwidth-efficient. Rather than depending on channel or device characteristics that are outside of our control, deliberate fingerprint embedding for message authentication enables control over performance trade-offs by design. Furthermore, low-power fingerprint designs enhance security by making the authentication tags less accessible to adversaries. We define metrics for communications and authentication performance, and discuss the trade-offs in system design. Results from our wireless software-defined radio experiments validate the theory and demonstrate the low complexity, practicality, and enhanced security of the approach. C1 [Yu, Paul L.; Verma, Gunjan; Sadler, Brian M.] US Army Res Lab, Adelphi, MD 20783 USA. RP Yu, PL (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. NR 14 TC 3 Z9 3 U1 7 U2 10 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0163-6804 EI 1558-1896 J9 IEEE COMMUN MAG JI IEEE Commun. Mag. PD JUN PY 2015 VL 53 IS 6 BP 48 EP 53 PG 6 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA CK3ZV UT WOS:000356157000008 ER PT J AU Vasterling, JJ Taft, CT Proctor, SP Macdonald, HZ Lawrence, A Kalill, K Kaiser, AP Lee, LO King, DW King, LA Fairbank, JA AF Vasterling, Jennifer J. Taft, Casey T. Proctor, Susan P. Macdonald, Helen Z. Lawrence, Amy Kalill, Kathleen Kaiser, Anica P. Lee, Lewina O. King, Daniel W. King, Lynda A. Fairbank, John A. TI Establishing a methodology to examine the effects of war-zone PTSD on the family: the family foundations study SO INTERNATIONAL JOURNAL OF METHODS IN PSYCHIATRIC RESEARCH LA English DT Article DE war-zone veterans; family; PTSD; longitudinal; risk factors ID POSTTRAUMATIC-STRESS-DISORDER; MILITARY SERVICE MEMBERS; MALE VIETNAM VETERANS; NEUROCOGNITION DEPLOYMENT HEALTH; INTIMATE PARTNER VIOLENCE; ALCOHOL-USE DISORDERS; YOUNG-CHILDREN; MENTAL-HEALTH; US MILITARY; HEAD-INJURY AB Military deployment may adversely affect not only returning veterans, but their families, as well. As a result, researchers have increasingly focused on identifying risk and protective factors for successful family adaptation to war-zone deployment, re-integration of the returning veteran, and the longer-term psychosocial consequences of deployment experienced by some veterans and families. Post-traumatic stress disorder (PTSD) among returning veterans may pose particular challenges to military and military veteran families; however, questions remain regarding the impact of the course of veteran PTSD and other potential moderating factors on family adaptation to military deployment. The Family Foundations Study builds upon an established longitudinal cohort of Army soldiers (i.e. the Neurocognition Deployment Health Study) to help address remaining knowledge gaps. This report describes the conceptual framework and key gaps in knowledge that guided the study design, methodological challenges and special considerations in conducting military family research, and how these gaps, challenges, and special considerations are addressed by the study. Copyright (c) 2015 John Wiley & Sons, Ltd. C1 [Vasterling, Jennifer J.; Taft, Casey T.; Kaiser, Anica P.; Lee, Lewina O.; King, Daniel W.; King, Lynda A.] VA Boston Healthcare Syst, VA Natl Ctr PTSD, Boston, MA 02130 USA. [Vasterling, Jennifer J.; Taft, Casey T.; Lawrence, Amy; Kalill, Kathleen; Kaiser, Anica P.; Lee, Lewina O.; King, Daniel W.; King, Lynda A.] Boston Univ, Sch Med, Boston, MA 02118 USA. [Proctor, Susan P.] US Army Res Inst Environm Med, Boston, MA USA. [Proctor, Susan P.] Boston Univ, Sch Publ Hlth, Boston, MA USA. [Macdonald, Helen Z.] Univ Cambridge Emmanuel Coll, Boston, MA USA. [Lawrence, Amy; Kalill, Kathleen] VA Boston Healthcare Syst, Boston, MA 02130 USA. [Fairbank, John A.] Duke Univ, Durham VA Med Ctr, VA Mid Atlantic VISN 6, MIRECC, Durham, NC USA. RP Vasterling, JJ (reprint author), VA Boston Healthcare Syst, Psychol 116B, 150 S Huntington Ave, Boston, MA 02130 USA. EM jennifer.vasterling@va.gov FU National Institute for Mental Health [1R01MH094422-02]; VA National Center for PTSD FX The Family Foundations Study is supported by the National Institute for Mental Health (1R01MH094422-02). A related pilot phase was supported by the VA National Center for PTSD. Interface with VA CSP #566 has been greatly facilitated by the VA Cooperative Studies Program Central Office and the Clinical Epidemiological Research Center at VA Connecticut Healthcare System. The authors also appreciate the assistance of Ms Molly Franz in initiating the study, the assistance of Ms Rebecca Wilken in both the on-going conduct of the study and manuscript preparation, and the contributions of Dr Michael Suvak to a previous version of the quantitative methodology. NR 86 TC 1 Z9 1 U1 8 U2 23 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1049-8931 EI 1557-0657 J9 INT J METH PSYCH RES JI Int. J. Methods Psychiatr. Res. PD JUN PY 2015 VL 24 IS 2 BP 143 EP 155 DI 10.1002/mpr.1464 PG 13 WC Psychiatry SC Psychiatry GA CK5ZP UT WOS:000356307600004 PM 26077194 ER PT J AU White, NJ Contaifer, D Martin, EJ Newton, JC Mohammed, BM Bostic, JL Brophy, GM Spiess, BD Pusateri, AE Ward, KR Brophy, DF AF White, N. J. Contaifer, D., Jr. Martin, E. J. Newton, J. C. Mohammed, B. M. Bostic, J. L. Brophy, G. M. Spiess, B. D. Pusateri, A. E. Ward, K. R. Brophy, D. F. TI Early hemostatic responses to trauma identified with hierarchical clustering analysis SO JOURNAL OF THROMBOSIS AND HAEMOSTASIS LA English DT Article DE coagulation; fibrinogen; hemostasis; platelets; thrombin; trauma ID PLATELET DYSFUNCTION; INJURED PATIENTS; COAGULOPATHY; HYPERFIBRINOLYSIS; ACTIVATION; SYSTEM; TISSUE; DAMAGE; MODEL AB BackgroundTrauma-induced coagulopathy is a complex multifactorial hemostatic response that is poorly understood. ObjectivesTo identify distinct hemostatic responses to trauma and identify key components of the hemostatic system that vary between responses. Patients/MethodsA cross-sectional observational study of adult trauma patients at an urban levelI trauma center emergency department was performed. Hierarchical clustering analysis was used to identify distinct clusters of similar subjects according to vital signs, injury/shock severity, and comprehensive assessment of coagulation, clot formation, platelet function, and thrombin generation. ResultsAmong 84 total trauma patients included in the model, three distinct trauma clusters were identified. Cluster1 (N=57) showed platelet activation, preserved peak thrombin generation, plasma coagulation dysfunction, a moderately decreased fibrinogen concentration and normal clot formation relative to healthy controls. Cluster2 (N=18) showed platelet activation, preserved peak thrombin generation, and a preserved fibrinogen concentration with normal clot formation. Cluster3 (N=9) was the most severely injured and shocked, and showed a strong inflammatory and bleeding phenotype. Platelet dysfunction, thrombin inhibition, plasma coagulation dysfunction and a decreased fibrinogen concentration were present in this cluster. Fibrinolytic activation was present in all clusters, but was particularly increased in cluster3. Trauma clusters were most noticeably different in their relative fibrinogen concentration, peak thrombin generation, and platelet-induced clot contraction. ConclusionsHierarchical clustering analysis identified three distinct hemostatic responses to trauma. Further insights into the underlying hemostatic mechanisms responsible for these responses are needed. C1 [White, N. J.] Univ Washington, Dept Med, Div Emergency Med, Seattle, WA USA. [White, N. J.] Puget Sound Blood Ctr, Res Inst, Seattle, WA 98104 USA. [Contaifer, D., Jr.; Martin, E. J.; Newton, J. C.; Mohammed, B. M.; Bostic, J. L.; Brophy, D. F.] Virginia Commonwealth Univ, Coagulat Adv Lab, Dept Pharmacotherapy & Outcomes Sci, Richmond, VA USA. [Mohammed, B. M.] Cairo Univ, Dept Clin Pharm, Fac Pharm, Cairo, Egypt. [Brophy, G. M.] Virginia Commonwealth Univ, Pharmacotherapy & Outcomes Sci & Dept Neurosurg, Richmond, VA USA. [Spiess, B. D.] Virginia Commonwealth Univ, Dept Anesthesiol, Richmond, VA USA. [Pusateri, A. E.] US Army Med Res & Mat Command, Ft Detrick, MD USA. [Ward, K. R.] Univ Michigan, Michigan Ctr Integrat Res Crit Care, Ann Arbor, MI 48109 USA. RP White, NJ (reprint author), Harborview Med Ctr, Div Emergency Med, Box 359702,329 9th Ave, Seattle, WA 98199 USA. EM whiten4@uw.edu FU US Defense Health Program, US Army Medical Research and Materiel Command [W81XWH-11-2-0089]; National Center for Advancing Translational Sciences (NCATS), a component of the National Institutes of Health (NIH) [KL2 TR000421] FX This study was supported by the US Defense Health Program, US Army Medical Research and Materiel Command grant W81XWH-11-2-0089. N. J. White is supported, in part, by the National Center for Advancing Translational Sciences (NCATS) (grant KL2 TR000421), a component of the National Institutes of Health (NIH). The views expressed in this article are those of the authors, and do not necessarily reflect the official policy or position of the Departments of the Army and Defense, or the US Government, and do not necessarily represent the official view of the NCATS or the NIH. NR 26 TC 4 Z9 4 U1 2 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1538-7933 EI 1538-7836 J9 J THROMB HAEMOST JI J. Thromb. Haemost. PD JUN PY 2015 VL 13 IS 6 BP 978 EP 988 DI 10.1111/jth.12919 PG 11 WC Hematology; Peripheral Vascular Disease SC Hematology; Cardiovascular System & Cardiology GA CJ8JK UT WOS:000355746100011 PM 25816845 ER PT J AU Lin, L Finak, G Ushey, K Seshadri, C Hawn, TR Frahm, N Scriba, TJ Mahomed, H Hanekom, W Bart, PA Pantaleo, G Tomaras, GD Rerks-Ngarm, S Kaewkungwal, J Nitayaphan, S Pitisuttithum, P Michael, NL Kim, JH Robb, ML O'Connell, RJ Karasavvas, N Gilbert, P De Rosa, SC McElrath, MJ Gottardo, R AF Lin, Lin Finak, Greg Ushey, Kevin Seshadri, Chetan Hawn, Thomas R. Frahm, Nicole Scriba, Thomas J. Mahomed, Hassan Hanekom, Willem Bart, Pierre-Alexandre Pantaleo, Giuseppe Tomaras, Georgia D. Rerks-Ngarm, Supachai Kaewkungwal, Jaranit Nitayaphan, Sorachai Pitisuttithum, Punnee Michael, Nelson L. Kim, Jerome H. Robb, Merlin L. O'Connell, Robert J. Karasavvas, Nicos Gilbert, Peter De Rosa, Stephen C. McElrath, M. Juliana Gottardo, Raphael TI COMPASS identifies T-cell subsets correlated with clinical outcomes SO NATURE BIOTECHNOLOGY LA English DT Article ID FLOW-CYTOMETRY DATA; TUBERCULOSIS INFECTION; IMMUNE-RESPONSE; SOUTH-AFRICA; VACCINE; VIRUS; IMMUNIZATION; ASSAYS; TRIAL AB Advances in flow cytometry and other single-cell technologies have enabled high-dimensional, high-throughput measurements of individual cells as well as the interrogation of cell population heterogeneity. However, in many instances, computational tools to analyze the wealth of data generated by these technologies are lacking. Here, we present a computational framework for unbiased combinatorial polyfunctionality analysis of antigen-specific T-cell subsets (COMPASS). COMPASS uses a Bayesian hierarchical framework to model all observed cell subsets and select those most likely to have antigen-specific responses. Cell-subset responses are quantified by posterior probabilities, and human subject-level responses are quantified by two summary statistics that describe the quality of an individual's polyfunctional response and can be correlated directly with clinical outcome. Using three clinical data sets of cytokine production, we demonstrate how COMPASS improves characterization of antigen-specific T cells and reveals cellular 'correlates of protection/immunity' in the RV144 HIV vaccine efficacy trial that are missed by other methods. COMPASS is available as open-source software. C1 [Lin, Lin; Finak, Greg; Ushey, Kevin; Frahm, Nicole; Gilbert, Peter; De Rosa, Stephen C.; McElrath, M. Juliana; Gottardo, Raphael] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98104 USA. [Seshadri, Chetan; Hawn, Thomas R.; McElrath, M. Juliana] Univ Washington, Div Allergy & Infect Dis, Seattle, WA 98195 USA. [Scriba, Thomas J.; Mahomed, Hassan; Hanekom, Willem] Univ Cape Town, Inst Infect Dis & Mol Med, South African TB Vaccine Initiat, ZA-7925 Cape Town, South Africa. [Mahomed, Hassan; Hanekom, Willem] Univ Cape Town, Sch Child & Adolescent Hlth, ZA-7925 Cape Town, South Africa. [Bart, Pierre-Alexandre; Pantaleo, Giuseppe] Univ Vaudois, Ctr Hosp, Lausanne, Switzerland. [Tomaras, Georgia D.] Duke Univ, Med Ctr, Duke Human Vaccine Inst, Durham, NC USA. [Rerks-Ngarm, Supachai] Minist Publ Hlth, Dept Dis Control, Nonthaburi, Thailand. [Kaewkungwal, Jaranit] Mahidol Univ, Fac Trop Med, Data Management Unit, Bangkok, Thailand. [Nitayaphan, Sorachai] Thai Component, Armed Forces Res Inst Med Sci, Bangkok, Thailand. [Pitisuttithum, Punnee] Mahidol Univ, Fac Trop Med, Vaccine Trials Ctr, Bangkok, Thailand. [Michael, Nelson L.; Kim, Jerome H.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Robb, Merlin L.] Henry M Jackson Fdn, Walter Reed Army Inst Res, US Army Mil HIV Res Program, Bethesda, MD USA. [O'Connell, Robert J.; Karasavvas, Nicos] Armed Forces Res Inst Med Sci, US Army Med Component, Bangkok 10400, Thailand. [De Rosa, Stephen C.; McElrath, M. Juliana] Univ Washington, Dept Lab Med, Seattle, WA 98195 USA. RP Gottardo, R (reprint author), Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, 1124 Columbia St, Seattle, WA 98104 USA. EM rgottard@fredhutch.org RI Tomaras, Georgia/J-5041-2016; Pantaleo, Giuseppe/K-6163-2016; OI Finak, Greg/0000-0003-4341-9090; Lin, Lin/0000-0002-7464-1172 FU National Institute of Health grants [R01 EB008400, UM1 AI068635, UM1 AI068618]; Human Immunology Phenotyping Consortium [U19 AI089986]; Collaboration for AIDS Vaccine Discovery [OPP1032325]; US Army Medical Research and Material Command [Y1-AI-2642-12]; National Institutes of Allergy and Infectious Diseases [Y1-AI-2642-12]; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; US Department of Defense [W81XWH-07-2-0067] FX This work was funded by National Institute of Health grants (R01 EB008400), and grants (UM1 AI068635) and (UM1 AI068618) to the HIV Vaccine Trials Network (HVTN) and the Statistical Data Management Center (SDMC), the Human Immunology Phenotyping Consortium (U19 AI089986), and the Collaboration for AIDS Vaccine Discovery (OPP1032325). The work was also supported in part by an Interagency Agreement Y1-AI-2642-12 between the US Army Medical Research and Material Command and the National Institutes of Allergy and Infectious Diseases and by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the US Department of Defense. We also acknowledge G. Peterson for technical assistance with all assays related to the TB data set. NR 30 TC 23 Z9 23 U1 2 U2 9 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1087-0156 EI 1546-1696 J9 NAT BIOTECHNOL JI Nat. Biotechnol. PD JUN PY 2015 VL 33 IS 6 BP 610 EP + DI 10.1038/nbt.3187 PG 9 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA CK2DE UT WOS:000356019700020 PM 26006008 ER PT J AU Shaw, AP Diviacchi, G Black, EL Moretti, JD Sadangi, RK Grau, HA Gilbert, RA AF Shaw, Anthony P. Diviacchi, Giancarlo Black, Ernest L. Moretti, Jared D. Sadangi, Rajendra K. Grau, Henry A., Jr. Gilbert, Robert A., Jr. TI Versatile Boron Carbide-Based Visual Obscurant Compositions for Smoke Munitions SO ACS SUSTAINABLE CHEMISTRY & ENGINEERING LA English DT Article DE Smoke; Obscurants; Pyrotechnics; Boron carbide; Sustainable chemistry ID PYROTECHNICS AB New pyrotechnic smoke compositions, containing only environmentally benign materials, have been demonstrated to produce thick white smoke clouds upon combustion. These compositions use powdered boron carbide (B4C) as a pyrotechnic fuel, KNO3 as a pyrotechnic oxidizer, and KCl as a combustion temperature moderator. Small amounts of calcium stearate and polymeric binders may be added to moderate burning rate and for composition granulation. Prototype tests involving three preferred compositions were conducted in end- and core-burning grenade and canister configurations. Smoke release times ranged from 3.5 to 70 s for the grenades and from 8 to 100 s for the canisters. Notably, any desired smoke release time within these ranges may be obtained by fine adjustment to the calcium stearate content of the compositions and/or small changes to the device containers. Aerosolization efficiency and quantitative performance, as determined by smoke chamber measurements, remain consistent regardless of smoke release time. Impact, friction, and electrostatic discharge tests show that the compositions are insensitive to accidental ignition and are safe to handle. C1 [Shaw, Anthony P.; Moretti, Jared D.; Sadangi, Rajendra K.; Grau, Henry A., Jr.; Gilbert, Robert A., Jr.] US Army RDECOM ARDEC, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07806 USA. [Diviacchi, Giancarlo; Black, Ernest L.] US Army RDECOM ECBC, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Shaw, AP (reprint author), US Army RDECOM ARDEC, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07806 USA. EM anthony.p.shaw.civ@mail.mil FU U.S. Army FX Karl D. Oyler and Jessica A. Vanatta are thanked for particle size measurements. Charles C. Young is thanked for organizing and weighing starting materials. Mark G. Ward and Mark J. Hull are thanked for test setup. Joseph A. Domanico is thanked for providing customized canister hardware and for spirited discussion. Noah Lieb, William S. Eck, Mark S. Johnson, Jesse J. Sabatini, Jay C. Poret, and Christopher M. Csernica are thanked for encouraging conversations. The U.S. Army is thanked for funding this work through the RDECOM Environmental Quality Technology Program. NR 24 TC 2 Z9 2 U1 3 U2 12 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 2168-0485 J9 ACS SUSTAIN CHEM ENG JI ACS Sustain. Chem. Eng. PD JUN PY 2015 VL 3 IS 6 BP 1248 EP 1254 DI 10.1021/acssuschemeng.5b00245 PG 7 WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Chemical SC Chemistry; Science & Technology - Other Topics; Engineering GA CJ6ZZ UT WOS:000355645000027 ER PT J AU Barnard, EBG Moy, RJ Kehoe, AD Bebarta, VS Smith, JE AF Barnard, E. B. G. Moy, R. J. Kehoe, A. D. Bebarta, V. S. Smith, J. E. TI Rapid sequence induction of anaesthesia via the intraosseous route: a prospective observational study SO EMERGENCY MEDICINE JOURNAL LA English DT Article ID VASCULAR ACCESS; SERVICE; CARE; UK AB Background Intraosseous (IO) drug infusion has been reported to have similar pharmacokinetics to intravenous (IV) infusion. In military and civilian trauma, the IO route is often used to obtain rapid and reliable parenteral access for drug administration. Only a few case reports have described the use of IO infusion to administer drugs for rapid sequence induction of anaesthesia (RSI). Objective We aimed to assess the feasibility of the administration of RSI drugs via an IO catheter in a prospective observational study. Methods A prospective observational study was undertaken at a combat hospital in Afghanistan. A validated data form was used to record the use of IO drugs for RSI by the prehospital, physician-led Medical Emergency Response Team (MERT), and by inhospital physicians. Data were captured between January and May 2012 by interview with MERT physicians and inhospital physicians directly after RSI. The primary outcome measure was the success rate of first-pass intubation with direct laryngoscopy. Results 34 trauma patients (29 MERT and 5 inhospital) underwent RSI with IO drug administration. The median age was 24 years and median injury severity score 25; all were male. The predominant mechanism of injury was blast (n=24), followed by penetrating (n=6), blunt (n=3) and burn (n=1). First-pass intubation success rate was 97% (95% CI 91% to 100%). A Cormack-Lehane grade 1 view, by direct laryngoscopy, was obtained at first look in 91% (95% CI 81% to 100%) of patients. Conclusions In this prospective, observational study, IO drug administration was successfully used for trauma RSI, with a comparable first pass intubation success than published studies describing the IV route. C1 [Barnard, E. B. G.; Bebarta, V. S.] San Antonio Mil Med Ctr, Air Force En Route Care Res Ctr, San Antonio, TX USA. [Barnard, E. B. G.] Inst Naval Med, Alverstoke, Hants, England. [Moy, R. J.] Glasgow Royal Infirm, Emergency Dept, Glasgow G4 0SF, Lanark, Scotland. [Kehoe, A. D.; Smith, J. E.] Derriford Hosp, Emergency Dept, Plymouth, Devon, England. [Smith, J. E.] Royal Ctr Def Med Res & Acad, Acad Dept Mil Emergency Med, Birmingham, W Midlands, England. RP Barnard, EBG (reprint author), US Army Inst Surg Res, En Route Care Res Ctr, Royal Navy, San Antonio, TX 78234 USA. EM ukbarnard@gmail.com RI bebarta, vikhyat/K-3476-2015; OI Smith, Jason/0000-0002-6143-0421 NR 19 TC 5 Z9 6 U1 0 U2 3 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1472-0205 EI 1472-0213 J9 EMERG MED J JI Emerg. Med. J. PD JUN PY 2015 VL 32 IS 6 BP 449 EP 452 DI 10.1136/emermed-2014-203740 PG 4 WC Emergency Medicine SC Emergency Medicine GA CJ1TU UT WOS:000355268200009 PM 24963149 ER PT J AU Snyder, JF Gienger, EB Wetzel, ED AF Snyder, J. F. Gienger, E. B. Wetzel, E. D. TI Performance metrics for structural composites with electrochemical multifunctionality SO JOURNAL OF COMPOSITE MATERIALS LA English DT Article DE Smart materials; multifunctional composite; polymer matrix composites; electrical properties; mechanical properties; synergism ID LITHIUM BATTERY ELECTROLYTES; ENERGY-STORAGE; POLYMER ELECTROLYTES; ION BATTERIES; DESIGN; CAPACITORS; SYSTEMS AB Structural electrochemical composites, which are capable of carrying mechanical loads while simultaneously storing or releasing electrical energy, combine the components and behaviors of conventional polymer composite structures and electrochemical devices such as batteries and supercapacitors into a single multifunctional material. In order to analyze these systems more rigorously, this paper derives relationships and metrics for the mass savings of a multifunctional design relative to a design consisting of conventional structures and electrochemical devices. These metrics are then evaluated using structural supercapacitors composed of carbon fiber electrodes and conductive solid polymer electrolytes, as well as multifunctional supercapacitors from literature. The analysis reveals that state-of-the-art multifunctional supercapacitors are still far from reaching the levels of performance needed to supplant conventional structures and save system mass. The metrics provide further insight regarding multifunctional value of the material components as well as influence of various functionalities on system performance. C1 [Snyder, J. F.; Gienger, E. B.; Wetzel, E. D.] US Army Res Lab, Mat & Mfg Sci Div, Aberdeen Proving Ground, MD 21005 USA. RP Snyder, JF (reprint author), US Army Res Lab, Mat & Mfg Sci Div, ATTN RDRL WMM G, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA. EM james.f.snyder.civ@mail.mil FU Postgraduate Research Participation Program at the U.S. Army Research Laboratory FX The authors gratefully acknowledge Dr Danny O'Brien, Mr Dan Baechle, and Dr Kang Xu for informative discussions. Edwin Gienger was supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Research Laboratory administered by the Oak Ridge Institute for Science and Education through an inter-agency agreement between the U.S. Department of Energy and USARL. Certain commercial equipment and materials are identified in this paper in order to specify adequately the experimental procedure. In no case does such identification imply recommendations by the Army Research Laboratory or does it imply that the material or equipment identified is necessarily the best available for this purpose. NR 35 TC 2 Z9 2 U1 1 U2 21 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0021-9983 EI 1530-793X J9 J COMPOS MATER JI J. Compos Mater. PD JUN PY 2015 VL 49 IS 15 SI SI BP 1835 EP 1848 DI 10.1177/0021998314568167 PG 14 WC Materials Science, Composites SC Materials Science GA CJ8NM UT WOS:000355759700005 ER PT J AU Crowell, MS Tragord, BS AF Crowell, Michael S. Tragord, Bradley S. TI Orthopaedic Manual Physical Therapy for Shoulder Pain and Impaired Movement in a Patient With Glenohumeral Joint Osteoarthritis: A Case Report SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE arthritis; functional limitation; glenoid erosion; labral tear; scapular weakness; stiffness ID RANDOMIZED CLINICAL-TRIAL; FUNCTIONAL SCALE; ANTERIOR INSTABILITY; IMPINGEMENT SYNDROME; EXERCISE THERAPY; USUAL CARE; KNEE; MANAGEMENT; STABILIZATION; METAANALYSIS AB STUDY DESIGN: Case report. BACKGROUND: Comprehensive treatment strategies are needed for individuals with glenohumeral joint osteoarthritis (OA), especially when they are young and active. Prior dislocation, with or without subsequent shoulder stabilization surgery, complicates the clinical presentation and increases the risk of OA progression. The purpose of this case report was to describe an orthopaedic manual physical therapy approach used in a patient with glenohumeral joint OA who presented with shoulder pain and impaired movement. CASE DESCRIPTION: A 38-year-old male military officer presented with left-shoulder pain of 2 months in duration that was unrelieved with a subacromial injection. He reported a history of anterior-inferior dislocation with subsequent stabilization surgery 15 years prior and arthroscopic subacromial decompression 2 years prior. Physical examination demonstrated painful limitations in shoulder elevation and internal/external rotation movements, stiffness with testing using accessory glides, and rotator cuff and scapular musculature weakness associated with pain. OUTCOMES: Treatment consisted of 5 sessions provided over 4 weeks. The plan of care included manual physical therapy, exercises, and progressive functional activities specifically tailored to the patient's clinical presentation. Shoulder Pain and Disability Index scores decreased from 43% to 17%, and the Patient-Specific Functional Scale average score improved from 3.0 to 7.3 out of 10. After 4 additional weeks of a home exercise program, the Shoulder Pain and Disability Index score was 4% and Patient-Specific Functional Scale average score was 9.0. Improvements in self-reported function were maintained at 6 months. Four "booster" treatment sessions were administered at 9 months, contributing to sustained outcomes through 1 year. DISCUSSION: In a young, active patient with glenohumeral joint OA, clinically meaningful short-term improvements in self-reported function and pain, maintained at 1 year, were observed with manual physical therapy and exercise. C1 [Crowell, Michael S.] Army Baylor Sports Phys Therapy Doctoral Program, West Point, NY USA. [Crowell, Michael S.] Keller Army Community Hosp, West Point, NY USA. [Tragord, Bradley S.] Moncrief Army Community Hosp, Ft Jackson, SC USA. RP Crowell, MS (reprint author), 3348 East Continental Rd, West Point, NY 10996 USA. EM michael.s.crowell.mil@mail.mil NR 54 TC 1 Z9 1 U1 2 U2 13 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD JUN PY 2015 VL 45 IS 6 BP 453 EP 461 DI 10.2519/jospt.2015.5887 PG 9 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA CJ6BL UT WOS:000355577900003 PM 25927500 ER PT J AU Bulathsinhala, L Hill, OT Scofield, DE Haley, TF Kardouni, JR AF Bulathsinhala, Lakmini Hill, Owen T. Scofield, Dennis E. Haley, Timothy F. Kardouni, Joseph R. TI Epidemiology of Ankle Sprains and the Risk of Separation From Service in US Army Soldiers SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE length of service; lower extremity injury; musculoskeletal injury; recurrent injury; survival analysis ID UNITED-STATES; INJURY; DISABILITY; INSTABILITY; POPULATION; DEFICITS; SPORTS; RATES AB STUDY DESIGN: Retrospective cohort study. OBJECTIVES: To report the incidence rate of ankle sprains in active-duty soldiers and to examine if soldiers who sustain ankle sprain injuries are more likely to leave the Army than those who do not sustain an ankle sprain. BACKGROUND: Ankle sprains are one of the most common musculoskeletal injuries in physically active people and have been identified as the most common foot or ankle injury in active-duty Army personnel, with a rate of 103 sprains per 1000 soldiers per year. METHODS: Data were analyzed on the entire active-duty US Army population from 2000 to 2006 (n = 1014 042). A semi-parametric Cox proportional hazard model was built. RESULTS: The overall incidence rate for ankle sprains was 45.14 per 1000 person-years. After controlling for length of service prior to the study period, soldiers who sustained a single ankle sprain were 27% less likely (relative risk ratio = 0.73; 95% confidence interval: 0.73, 0.75) to leave the service than soldiers who had no documented history of an ankle sprain. However, this trend toward increased service time no longer held true for those who sustained a recurrent sprain (risk ratio = 1.07; 95% confidence interval: 0.99, 1.15). CONCLUSION: It appears that individuals who sustain an incident ankle sprain have longer time in service in the Army than those who do not sustain this injury. However, this trend toward longer service time no longer held true for soldiers who sustained a recurrent sprain. This could be an indication that preventing recurrent injury could factor into longer periods of military service. C1 [Bulathsinhala, Lakmini; Scofield, Dennis E.; Kardouni, Joseph R.] US Army Res Inst Environm Med, Mil Performance Div, Natick, MA 01760 USA. [Hill, Owen T.] Extrem Trauma & Amputat Ctr Excellence, Ctr Intrepid, Ft Sam Houston, TX USA. [Haley, Timothy F.] First Army Div West, Ft Hood, TX USA. RP Bulathsinhala, L (reprint author), US Army Res Inst Environm Med, Mil Performance Div, 15 Kansas St,Bldg 42, Natick, MA 01760 USA. EM lakmini.bulathsinhala.ctr@mail.mil RI SCOFIELD, DENNIS/F-3636-2015 NR 28 TC 2 Z9 2 U1 0 U2 5 PU J O S P T PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 EI 1938-1344 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD JUN PY 2015 VL 45 IS 6 BP 477 EP 484 DI 10.2519/jospt.2015.5733 PG 8 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA CJ6BL UT WOS:000355577900006 PM 25899214 ER PT J AU Harrison, GF Scheirer, JL Melanson, VR AF Harrison, Genelle F. Scheirer, Jessica L. Melanson, Vanessa R. TI Development and validation of an arthropod maceration protocol for zoonotic pathogen detection in mosquitoes and fleas SO JOURNAL OF VECTOR ECOLOGY LA English DT Article DE Vector pathogen detection; nucleic acid extraction; biosurveillance ID PCR ASSAY; QUANTIFICATION; FEVER AB Arthropod-borne diseases remain a pressing international public health concern. While progress has been made in the rapid detection of arthropod-borne pathogens via quantitative real-time (qPCR), or even hand-held detection devices, a simple and robust maceration and nucleic acid extraction method is necessary to implement biosurveillance capabilities. In this study, a comparison of maceration techniques using five types of beads followed by nucleic acid extraction and detection were tested using two morphologically disparate arthropods, the Aedes aegypti mosquito and Xenopsylla spp. flea, to detect the zoonotic diseases dengue virus serotype-1 and Yersinia pestis. Post-maceration nucleic acid extraction was carried out using the 1-2-3 Platinum-Path-Sample-Purification (PPSP) kit followed by qPCR detection using the Joint Biological Agent Identification and Diagnostic System (JBAIDS). We found that the 5mm stainless steel beads added to the beads provided in the PPSP kit were successful in macerating the exoskeleton for both Ae. aegypti and Xenopsylla spp. Replicates in the maceration/extraction/detection protocol were increased in a stepwise fashion until a final 128 replicates were obtained. For dengue virus detection there was a 99% positivity rate and for Y. pestis detection there was a 95% positive detection rate. In the examination of both pathogens, there were no significant differences between qPCR instruments, days ran, time of day ran, or operators. C1 [Harrison, Genelle F.] McGill Univ, Montreal, PQ H3A 1B1, Canada. [Scheirer, Jessica L.; Melanson, Vanessa R.] Walter Reed Army Inst Res, Entomol Branch, Diagnost & Lab Serv Dept, Silver Spring, MD 20910 USA. RP Melanson, VR (reprint author), Walter Reed Army Inst Res, Entomol Branch, Diagnost & Lab Serv Dept, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM vanessa.melanson@us.army.mil FU Medical Countermeasures Systems (MCS) [SP-1 9R24] FX We thank Drs. Scott W. Bearden and Kenneth Gage from the CDC National Center for Emerging and Zoonotic Infectious Diseases Division of Vector-Borne Diseases for providing us with attenuated Y. pestis -infected fleas, Tobin Rowland (WRAIR) for providing us with the dengue-infected and uninfected mosquitoes and for his knowledge and insectary support, Robert Putnack (WRAIR) and his colleagues for proliferation of the dengue viral cultures used in this study, and Judith Stoffer, Walter Reed Biosystems Unit, for capturing the images of the arthropods during the protocol development and optimization portion of this study. This study was funded by the Medical Countermeasures Systems (MCS), formally known as the Chemical Biological Medical Systems (CBMS), SP-1 9R24. Material has been reviewed by the Walter Reed Army Institute of Research. There is no objection to its presentation and/or publication. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official, or as reflecting true views of the Department of the Army or the Department of Defense. Companies or specific equipment used during this study were selected by the authors and is not an endorsement by the Department of the Army or the Department of Defense. NR 13 TC 1 Z9 1 U1 0 U2 0 PU SOC VECTOR ECOLOGY PI CORONA PA 1966 COMPTON AVE, CORONA, CA 92881 USA SN 1081-1710 EI 1948-7134 J9 J VECTOR ECOL JI J. Vector Ecol. PD JUN PY 2015 VL 40 IS 1 BP 83 EP 89 DI 10.1111/jvec.12136 PG 7 WC Entomology SC Entomology GA CJ9VN UT WOS:000355851400011 PM 26047188 ER PT J AU Cole, W Edwards, MJ Burnett, MW AF Cole, Will Edwards, Mary J. Burnett, Mark W. TI Providing Care to Children in Times of War SO MILITARY MEDICINE LA English DT Editorial Material ID AFGHANISTAN; IRAQ AB The Geneva Conventions stipulate that an occupying power must ensure adequate health care delivery to noncombatants. Special emphasis is given to children, who are among the most vulnerable in a conflict zone. Whether short-term pediatric care should be provided by Military Treatment Facilities to local nationals for conditions other than combat-related injury is controversial. A review of 1,197 children without traumatic injury cared for during 10 years in Iraq and Afghanistan was conducted. Mortality rates were less than 1% among patients with surgical conditions and resource utilization was not excessive. In view of international humanitarian law and these outcomes, children with nontraumatic conditions can and should be considered for treatment at Military Treatment Facilities. The ability to correct the condition and availability of resources necessary to do so should be taken into account. C1 [Cole, Will] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96856 USA. [Edwards, Mary J.] Brooke Army Med Ctr, Dept Surg, Houston, TX 78234 USA. [Burnett, Mark W.] Tripler Army Med Ctr, Dept Pediat, Honolulu, HI 96856 USA. RP Cole, W (reprint author), Tripler Army Med Ctr, Dept Surg, 1 Jarrett White Rd, Honolulu, HI 96856 USA. NR 10 TC 0 Z9 0 U1 1 U2 4 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JUN PY 2015 VL 180 IS 6 BP 609 EP 611 DI 10.7205/MILMED-D-14-00350 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA CJ5WM UT WOS:000355563400009 PM 26032375 ER PT J AU Murray, CK Yun, HC Markelz, AE Okulicz, JF Vento, TJ Burgess, TH Cardile, AP Miller, RS AF Murray, Clinton K. Yun, Heather C. Markelz, Ana Elizabeth Okulicz, Jason F. Vento, Todd J. Burgess, Timothy H. Cardile, Anthony P. Miller, R. Scott TI Operation United Assistance: Infectious Disease Threats to Deployed Military Personnel SO MILITARY MEDICINE LA English DT Article ID PLASMODIUM-FALCIPARUM MALARIA; RESPIRATORY-TRACT INFECTIONS; PHLEBOTOMINE SAND FLIES; TALLIL-AIR-BASE; HUMAN-IMMUNODEFICIENCY-VIRUS; TICK-BORNE RICKETTSIOSES; HEALTH-CARE PROVIDERS; RAPID DIAGNOSTIC-TEST; HUMAN CHALLENGE MODEL; YELLOW-FEVER VACCINE AB As part of the international response to control the recent Ebola outbreak in West Africa, the Department of Defense has deployed military personnel to train Liberians to manage the disease and build treatment units and a hospital for health care volunteers. These steps have assisted in providing a robust medical system and augment Ebola diagnostic capability within the affected nations. In order to prepare for the deployment of U.S. military personnel, the infectious disease risks of the regions must be determined. This evaluation allows for the establishment of appropriate force health protection posture for personnel while deployed, as well as management plans for illnesses presenting after redeployment. Our objective was to detail the epidemiology and infectious disease risks for military personnel in West Africa, particularly for Liberia, along with lessons learned from prior deployments. C1 [Murray, Clinton K.; Yun, Heather C.; Okulicz, Jason F.; Vento, Todd J.] San Antonio Mil Med Ctr, Jbsa Ft Sam Houston, TX 78234 USA. [Markelz, Ana Elizabeth] 48th Chem Brigade, Ft Hood, TX 76544 USA. [Burgess, Timothy H.] Walter Reed Natl Mil Med Ctr, Bethesda, MD 20889 USA. [Cardile, Anthony P.] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Miller, R. Scott] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biostat, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. RP Murray, CK (reprint author), San Antonio Mil Med Ctr, 3551 Roger Brooke Dr, Jbsa Ft Sam Houston, TX 78234 USA. NR 239 TC 1 Z9 1 U1 1 U2 4 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JUN PY 2015 VL 180 IS 6 BP 626 EP 651 DI 10.7205/MILMED-D-14-00691 PG 26 WC Medicine, General & Internal SC General & Internal Medicine GA CJ5WM UT WOS:000355563400013 PM 26032379 ER PT J AU Proctor, SP Nieto, K Heaton, KJ Dillon, CC Schlegel, RE Russell, ML Vincent, AS AF Proctor, Susan P. Nieto, Kenneth Heaton, Kristin J. Dillon, Caitlin C. Schlegel, Robert E. Russell, Michael L. Vincent, Andrea S. TI Neurocognitive Performance and Prior Injury Among US Department of Defense Military Personnel SO MILITARY MEDICINE LA English DT Article ID TRAUMATIC BRAIN-INJURY; NEUROPSYCHOLOGICAL ASSESSMENT METRICS; ASSOCIATION POSITION STATEMENT; SPORT-RELATED CONCUSSION; COGNITIVE IMPAIRMENT; SCREENING TOOL; REACTION-TIME; SAMPLE; ANAM; IRAQ AB This study examined the neurocognitive performance of U.S. military personnel completing the Automated Neuropsychological Assessment Metrics (version 4) TBI Military (ANAM4 TBI-MIL) battery as part of the Department of Defense Neurocognitive Functional Assessment Program. Descriptive analyses utilizing the ANAM4TBI Military Performance Database were performed. We examined ANAM Composite Score (ACS) differences between five injury subgroups (no injury, brain injury with current symptoms, brain injury without current symptoms, nonbrain injury with current symptoms, and nonbrain injury without current symptoms) using general linear mixed modeling. Almost 11% (70,472/641,285) reported brain injury in the 4 years before assessment. The ACS differed significantly by injury group (p < 0.0001). In comparison to the no injury group, those reporting brain injury with current symptoms (d = -0.44) and nonbrain injury with current symptoms (d = -0.24) demonstrated significantly reduced ACS scores (p < 0.0001) indicative of reduced neurocognitive proficiency. In this population-based study of U.S. military personnel, neurocognitive performance was significantly associated with reported injury within the past 4 years among those experiencing current symptoms. Occupational programs focusing on prospective brain health of injured population groups are warranted. C1 [Proctor, Susan P.; Nieto, Kenneth; Heaton, Kristin J.; Dillon, Caitlin C.] US Army, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. [Proctor, Susan P.; Heaton, Kristin J.] VA Boston Healthcare Syst, Res Serv, Boston, MA 02130 USA. [Proctor, Susan P.] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02118 USA. [Schlegel, Robert E.; Russell, Michael L.] US Army, Off Surg Gen, Neurocognit Assessment Branch, Ft Sam Houston, TX 78234 USA. [Russell, Michael L.] Dept Vet Affairs Ctr Excellence Res Returning War, Waco, TX 76711 USA. [Vincent, Andrea S.] Univ Oklahoma, Cognit Sci Res Ctr, Norman, OK 73072 USA. RP Proctor, SP (reprint author), US Army, Environm Med Res Inst, Mil Performance Div, Kansas St,Bldg 42, Natick, MA 01760 USA. FU U.S. Army Medical Research and Materiel Command [W81XWH-08-1-0021] FX We thank the staff at the U.S. Army Office of the Surgeon General, Neurocognitive Assessment Branch, as well as the DoD Defense Manpower Data Center for their support in this project. Funding for this project has been provided by the U.S. Army Medical Research and Materiel Command to the U.S. Army Research Institute of Environmental Medicine and through award #W81XWH-08-1-0021 (PI: SP Proctor) to the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. NR 39 TC 0 Z9 0 U1 2 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JUN PY 2015 VL 180 IS 6 BP 660 EP 669 DI 10.7205/MILMED-D-14-00298 PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA CJ5WM UT WOS:000355563400015 PM 26032381 ER PT J AU Clarke, T AF Clarke, Tim, Jr. TI Chauncy, the Copper Thermal Manikin SO MILITARY MEDICINE LA English DT Editorial Material C1 US Army Med Res & Mat Command, Natl Museum Hlth & Med, Silver Spring, MD 20910 USA. RP Clarke, T (reprint author), US Army Med Res & Mat Command, Natl Museum Hlth & Med, 2500 Linden Lane, Silver Spring, MD 20910 USA. NR 3 TC 0 Z9 0 U1 0 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JUN PY 2015 VL 180 IS 6 BP 718 EP 719 DI 10.7205/MILMED-D-15-00004 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA CJ5WM UT WOS:000355563400023 PM 26032389 ER PT J AU Hebert, JJ Koppenhaver, SL Teyhen, DS Walker, BF Fritz, JM AF Hebert, Jeffrey J. Koppenhaver, Shane L. Teyhen, Deydre S. Walker, Bruce F. Fritz, Julie M. TI The evaluation of lumbar multifidus muscle function via palpation: reliability and validity of a new clinical test SO SPINE JOURNAL LA English DT Article DE Low back pain; Diagnosis; Reliability; Validity; Skeletal muscle; Spine ID LOW-BACK-PAIN; CROSS-SECTIONAL AREA; TRANSVERSUS ABDOMINIS; SPINAL MANIPULATION; TRUNK MUSCLES; UNITED-STATES; ACTIVATION; DISABILITY; THICKNESS; EXERCISE AB BACKGROUND CONTEXT: The lumbar multifidus muscle provides an important contribution to lumbar spine stability, and the restoration of lumbar multifidus function is a frequent goal of rehabilitation. Currently, there are no reliable and valid physical examination procedures available to assess lumbar multifidus function among patients with low back pain. PURPOSE: To examine the inter-rater reliability and concurrent validity of the multifidus lift test (MLT) to identify lumbar multifidus dysfunction among patients with low back pain. STUDY DESIGN/SETTING: A cross-sectional analysis of reliability and concurrent validity performed in a university outpatient research facility. PATIENT SAMPLE: Thirty-two persons aged 18 to 60 years with current low back pain and a minimum modified Oswestry disability score of 20%. Study participants were excluded if they reported a history of lumbar spine surgery, lumbar radiculopathy, medical red flags, osteoporosis, or had recently been treated with spinal manipulation or trunk stabilization exercises. OUTCOME MEASURES: Concurrent measures of lumbar multifidus muscle function at the L4-L5 and L5-S1 levels were obtained with the MLT (index test) and real-time ultrasound imaging (reference standard). METHODS: The inter-rater reliability of the MLT was examined by measuring the level of agreement between two blinded examiners. Concurrent validity of the MLT was investigated by comparing clinicians' judgments with real-time ultrasound imaging measures of lumbar multifidus function. RESULTS: Inter-rater reliability of the MLT was substantial to excellent (kappa=0.75 to 0.81, p <=.01) and free from errors of bias and prevalence. When performed at L4-L5 or L5-S1, the MLT demonstrated evidence of concurrent validity through its relationship with the reference standard results at L4-L5 (r(bis)=0.59-0.73, p <=.01). The MLT generally failed to demonstrate a relationship with the reference standard results from the L5-S1 level. CONCLUSIONS: Our results provide preliminary evidence supporting the reliability and validity of the MLT to assess lumbar multifidus function at the L4-L5 spinal level. Additional research examining the measurement properties and utility of this test should be undertaken before confident implementation with patients. (C) 2015 Elsevier Inc. All rights reserved. C1 [Hebert, Jeffrey J.; Koppenhaver, Shane L.] Murdoch Univ, Sch Psychol & Exercise Sci, Perth, WA, Australia. [Koppenhaver, Shane L.; Teyhen, Deydre S.] US Army Baylor Univ, Doctoral Program Phys Therapy, San Antonio, TX USA. [Teyhen, Deydre S.] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. [Walker, Bruce F.] Murdoch Univ, Sch Hlth Profess, Perth, WA, Australia. [Fritz, Julie M.] Univ Utah, Dept Phys Therapy, Salt Lake City, UT USA. [Fritz, Julie M.] Intermt Healthcare, Salt Lake City, UT USA. RP Hebert, JJ (reprint author), Murdoch Univ, Sch Psychol & Exercise Sci, Murdoch, WA 6150, Australia. EM J.Hebert@Murdoch.edu.au OI Walker, Bruce/0000-0002-8506-6740; Hebert, Jeffrey/0000-0002-6959-325X FU National Institutes of Health, National Center for Complementary and Alternative Medicine [R21 AT004221] FX This study was supported by the National Institutes of Health, National Center for Complementary and Alternative Medicine (R21 AT004221). NR 50 TC 2 Z9 2 U1 0 U2 8 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1529-9430 EI 1878-1632 J9 SPINE J JI Spine Journal PD JUN 1 PY 2015 VL 15 IS 6 BP 1196 EP 1202 DI 10.1016/j.spinee.2013.08.056 PG 7 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA CI6NF UT WOS:000354875700015 PM 24314767 ER PT J AU del Rincon, I Polak, JF O'Leary, DH Battafarano, DF Erikson, JM Restrepo, JF Molina, E Escalante, A AF del Rincon, Inmaculada Polak, Joseph F. O'Leary, Daniel H. Battafarano, Daniel F. Erikson, John M. Restrepo, Jose F. Molina, Emily Escalante, Agustin TI Systemic inflammation and cardiovascular risk factors predict rapid progression of atherosclerosis in rheumatoid arthritis SO ANNALS OF THE RHEUMATIC DISEASES LA English DT Article DE Rheumatoid Arthritis; Atherosclerosis; Cardiovascular Disease ID INTIMA-MEDIA THICKNESS; SUBCLINICAL ATHEROSCLEROSIS; CAROTID ATHEROSCLEROSIS; METAANALYSIS; EVENTS; DISEASE; STRATIFICATION; ULTRASOUND; DESIGN; DAMAGE AB Objective To estimate atherosclerosis progression and identify influencing factors in rheumatoid arthritis (RA). Methods We used carotid ultrasound to measure intima-media thickness (IMT) in RA patients, and ascertained cardiovascular (CV) risk factors, inflammation markers and medications. A second ultrasound was performed approximately 3years later. We calculated the progression rate by subtracting the baseline from the follow-up IMT, divided by the time between the two scans. We used logistic regression to identify baseline factors predictive of rapid progression. We tested for interactions of erythrocyte sedimentation rate (ESR) with CV risk factors and medication use. Results Results were available for 487 RA patients. The mean (SD) common carotid IMT at baseline was 0.571mm (0.151). After a mean of 2.8years, the IMT increased by 0.050mm (0.055), p0.001, a progression rate of 0.018mm/year (95% CI 0.016 to 0.020). Baseline factors associated with rapid progression included the number of CV risk factors (OR 1.27 per risk factor, 95% CI 1.01 to 1.61), and the ESR (OR 1.12 per 10mm/h, 95% CI 1.02 to 1.23). The ESRxCV risk factor and ESRxmedication product terms were significant, suggesting these variables modify the association between the ESR and IMT progression. Conclusions Systemic inflammation and CV risk factors were associated with rapid IMT progression. CV risk factors may modify the role of systemic inflammation in determining IMT progression over time. Methotrexate and antitumour necrosis factor agents may influence IMT progression by reducing the effect of the systemic inflammation on the IMT. C1 [del Rincon, Inmaculada; Restrepo, Jose F.; Molina, Emily; Escalante, Agustin] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, Div Rheumatol & Clin Immunol, San Antonio, TX 78229 USA. [Erikson, John M.] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, Div Cardiol, San Antonio, TX 78229 USA. [Polak, Joseph F.; O'Leary, Daniel H.] Tufts Med Ctr, Ultrasound Reading Ctr, Boston, MA USA. [Battafarano, Daniel F.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP del Rincon, I (reprint author), Univ Texas Hlth Sci Ctr San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA. EM delrincon@uthscsa.edu FU National Institutes of Health [RO1-HL085742, RO1-HD37151, UL1-RR-025767] FX Supported by grants RO1-HL085742, RO1-HD37151, and UL1-RR-025767 from the National Institutes of Health. NR 32 TC 12 Z9 13 U1 0 U2 6 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0003-4967 EI 1468-2060 J9 ANN RHEUM DIS JI Ann. Rheum. Dis. PD JUN PY 2015 VL 74 IS 6 BP 1118 EP 1123 DI 10.1136/annrheumdis-2013-205058 PG 6 WC Rheumatology SC Rheumatology GA CH9QO UT WOS:000354371200025 PM 24845391 ER PT J AU Kane, CD Nuss, JE Bavari, S AF Kane, Christopher D. Nuss, Jonathan E. Bavari, Sina TI Novel therapeutic uses and formulations of botulinum neurotoxins: a patent review (2012-2014) SO EXPERT OPINION ON THERAPEUTIC PATENTS LA English DT Review DE antinociception; botulinum toxin; exocytosis; hydrogel; liposome; motor dysfunction; new indication; pain; spinal cord injury ID IDIOPATHIC DETRUSOR OVERACTIVITY; TARGETED SECRETION INHIBITORS; PLACEBO-CONTROLLED TRIAL; MOTOR-NERVE TERMINALS; SPINAL-CORD-INJURY; TOXIN TYPE-A; PROTEIN-RECEPTOR; DOUBLE-BLIND; SYNAPTOTAGMIN-II; CERVICAL DYSTONIA AB Introduction: Botulinum neurotoxins (BoNTs) are among the most toxic of known biological molecules and function as acetylcholine release inhibitors and neuromuscular blocking agents. Paradoxically, these properties also make them valuable therapeutic agents for the treatment of movement disorders, urological conditions and hypersecretory disorders. Greater understanding of their molecular mechanism of action and advances in protein engineering has led to significant efforts to improve and expand their function with a view towards broadening their therapeutic potential. Areas covered: Searches of Espacenet and Google Patent have revealed a number of patents related to BoNTs. This review will focus on novel therapeutic uses and formulations disclosed during 2012 - 2014. The seven patents discussed will include nanoformulations of FDA-approved BoNTs, additional BoNT subtypes and novel BoNT variants and chimeras created through protein engineering. Supporting patents and related publications are also briefly discussed. Expert opinion: The clinical and commercial success of BoNTs has prompted investigation into novel BoNTs or BoNT-mediated chimeras with promising in vitro results. Distinct strategies including the use of nanoformulations and targeted delivery have been implemented to identify new indication and improved functionality. Greater understanding of their systemic exposure, efficacy and safety profiles will be required for further development. C1 [Kane, Christopher D.] Henry M Jackson Fdn, Bethesda, MD USA. [Kane, Christopher D.] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, DoD Biotechnol High Performance Comp Software App, Frederick, MD USA. [Kane, Christopher D.; Nuss, Jonathan E.] US Army Med Res Inst Infect Dis, Div Mol & Translat Sci, Frederick, MD 21702 USA. [Nuss, Jonathan E.] Geneva Fdn, Tacoma, WA 98402 USA. [Bavari, Sina] US Army Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Kane, CD (reprint author), US Army Med Res Inst Infect Dis, Div Mol & Translat Sci, Frederick, MD 21702 USA. EM christopher.d.kane.ctr@mail.mil FU Joint Science and Technology Office - Chemical Biological Defense (JSTO-CBD) Defense Threat Reduction Agency (DTRA) [CB3675]; National Institutes of Health [5 U01AI082051-05] FX The views, findings, interpretations and recommendations are those of the authors and are not necessarily endorsed by the US Department of Health and Human Services or the US Army. The authors express their gratitude for financial support provided by the Joint Science and Technology Office - Chemical Biological Defense (JSTO-CBD) Defense Threat Reduction Agency (DTRA) under sponsor project number CCAR# CB3675 and National Institutes of Health (5 U01AI082051-05). The authors are indebted to Theresa Smith for providing many helpful discussions and they would also like to thank William F Discher for his assistance in creating the figures for this manuscript. The authors have no other relevant affiliations or financial involvements with the subject matter or materials discussed and indicate no potential conflicts of interest. NR 136 TC 4 Z9 4 U1 4 U2 16 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1354-3776 EI 1744-7674 J9 EXPERT OPIN THER PAT JI Expert Opin. Ther. Patents PD JUN PY 2015 VL 25 IS 6 BP 675 EP 690 DI 10.1517/13543776.2015.1030337 PG 16 WC Chemistry, Medicinal; Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA CI7NV UT WOS:000354951400005 PM 25842964 ER PT J AU Giannakis, GB Cendrillon, R Cevher, V Swami, A Tian, Z AF Giannakis, Georgios B. Cendrillon, Raphael Cevher, Volkan Swami, Ananthram Tian, Zhi TI Introduction to the Issue on Signal Processing for Big Data SO IEEE JOURNAL OF SELECTED TOPICS IN SIGNAL PROCESSING LA English DT Editorial Material C1 [Giannakis, Georgios B.] Univ Minnesota, Dept Elect & Comp Engn, Minneapolis, MN 55455 USA. [Cendrillon, Raphael] Google, Mountain View, CA 94043 USA. [Cevher, Volkan] Ecole Polytech Fed Lausanne, CH-1015 Lausanne, Switzerland. [Swami, Ananthram] Army Res Lab, Adelphi, MD 20783 USA. [Tian, Zhi] George Mason Univ, Dept Elect & Comp Engn, Fairfax, VA 22030 USA. RP Giannakis, GB (reprint author), Univ Minnesota, Dept Elect & Comp Engn, Minneapolis, MN 55455 USA. NR 0 TC 0 Z9 0 U1 3 U2 12 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1932-4553 EI 1941-0484 J9 IEEE J-STSP JI IEEE J. Sel. Top. Signal Process. PD JUN PY 2015 VL 9 IS 4 BP 583 EP 585 DI 10.1109/JSTSP.2015.2418393 PG 3 WC Engineering, Electrical & Electronic SC Engineering GA CI1DD UT WOS:000354480600001 ER PT J AU Jennissen, CA Peck, J Wetjen, K Hoogerwerf, P Harland, KK Denning, GM AF Jennissen, Charles A. Peck, Jeffrey Wetjen, Kristel Hoogerwerf, Pam Harland, Karisa K. Denning, Gerene M. TI The Safety Tips for ATV Riders (STARs) programme: short-term impact of a school-based educational intervention SO INJURY PREVENTION LA English DT Article ID TERRAIN-VEHICLE SAFETY; UNITED-STATES; INJURY PREVENTION; USE PATTERNS; CHILDREN; YOUTH; BEHAVIORS; KNOWLEDGE AB Background Since 1985, one-third of all US all-terrain vehicle (ATV)-related injuries and one-quarter of deaths involved victims <16 years of age. ATV safety education of youth could help reduce these tragedies. Objectives To assess the efficacy of the Safety Tips for ATV Riders (STARs) school-based programme targeting adolescents. Methods A survey was anonymously administered before and after the programme to determine demographics, knowledge and reported likelihood of using the information learned. Results Over 4600 students in 30 Iowa schools participated from November 2010 to April 2013. Initially, 52% knew most ATVs are designed for one rider, 25% knew the recommended vehicle size for their age range and 42% knew riding on Iowa's roads was legal only for agricultural purposes. After the programme, this increased to 92%, 82% and 76%, respectively (p < 0.0001 in each case), with 61% of students correct on all three. Better preintervention scores were associated with being males, higher riding frequency and being from isolated rural communities. After the programme, 48% and 32% said they were likely/very likely versus unlikely/very unlikely to use the safety information learned, respectively; younger students, females and infrequent riders reported higher likelihoods. Conclusions STARs increased short-term ATV safety knowledge and almost half the participants reported they would use the safety information presented. Males and frequent riders seemed more resistant, but some groups that may be more vulnerable to potential ATV crash and injury appeared amenable to the training with higher increases in postprogramme scores and greater intention of improving safety behaviours. C1 [Jennissen, Charles A.; Harland, Karisa K.; Denning, Gerene M.] Univ Iowa, Carver Coll Med, Dept Emergency Med, Iowa City, IA USA. [Peck, Jeffrey] US Army Corps Engineers, Iowa City, IA USA. [Wetjen, Kristel] Univ Iowa Hosp & Clin, Dept Surg, Div Pediat Surg, Iowa City, IA 52242 USA. [Wetjen, Kristel; Hoogerwerf, Pam] Univ Iowa, Childrens Hosp, Iowa City, IA USA. [Harland, Karisa K.] Iowa Injury Prevent Res Ctr, Iowa City, IA USA. RP Jennissen, CA (reprint author), Univ Iowa Hosp & Clin, Dept Emergency Med, 200 Hawkins Dr, Iowa City, IA 52242 USA. EM charles-jennissen@uiowa.edu FU University of Iowa Children's Hospital through Kohl's Cares, a community-based programme; Department of Emergency Medicine; Division of Pediatric Surgery at the University of Iowa FX Support for this study was primarily provided by the University of Iowa Children's Hospital through a grant awarded by Kohl's Cares, a community-based programme of Kohl's which supports kids' health and education initiatives nationwide. Additional funding was provided by the Department of Emergency Medicine and the Division of Pediatric Surgery at the University of Iowa. NR 35 TC 0 Z9 0 U1 0 U2 3 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1353-8047 EI 1475-5785 J9 INJURY PREV JI Inj. Prev. PD JUN PY 2015 VL 21 IS 3 BP 166 EP 172 DI 10.1136/injuryprev-2014-041408 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CI6KJ UT WOS:000354867600004 PM 25432939 ER PT J AU Gehrich, AP Lustik, MB Mehr, AA Patzwald, J AF Gehrich, A. P. Lustik, M. B. Mehr, A. A. Patzwald, J. TI RISK OF POSTOPERATIVE URINARY TRACT INFECTIONS FOLLOWING ANTI-INCONTINENCE OPERATIONS IN WOMEN UNDERGOING HYSTERECTOMY: A MULTIVARIABLE LOGISTIC REGRESSION ANALYSIS OF THE NSQIP DATA BANK SO INTERNATIONAL UROGYNECOLOGY JOURNAL LA English DT Article; Proceedings Paper CT 40th Annual Meeting of the International-Urogynecological-Association CY JUN 09-13, 2015 CL Nice, FRANCE SP Int Urogynecol Assoc C1 [Gehrich, A. P.; Mehr, A. A.; Patzwald, J.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Lustik, M. B.] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER LONDON LTD PI LONDON PA 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND SN 0937-3462 EI 1433-3023 J9 INT UROGYNECOL J JI Int. Urogynecol. J. PD JUN PY 2015 VL 26 SU 1 MA OP 077 BP S105 EP S106 PG 2 WC Obstetrics & Gynecology; Urology & Nephrology SC Obstetrics & Gynecology; Urology & Nephrology GA CI3AF UT WOS:000354619100078 ER PT J AU Gallagher, LA Ramage, E Weiss, EJ Radey, M Hayden, HS Held, KG Huse, HK Zurawski, DV Brittnacher, MJ Manoil, C AF Gallagher, Larry A. Ramage, Elizabeth Weiss, Eli J. Radey, Matthew Hayden, Hillary S. Held, Kiara G. Huse, Holly K. Zurawski, Daniel V. Brittnacher, Mitchell J. Manoil, Colin TI Resources for Genetic and Genomic Analysis of Emerging Pathogen Acinetobacter baumannii SO JOURNAL OF BACTERIOLOGY LA English DT Article ID TRANSPOSON MUTANT LIBRARY; INFECTIOUS-DISEASES-SOCIETY; PSEUDOMONAS-AERUGINOSA; CONJUGATIVE PLASMID; VIRULENCE FACTOR; RNA GENES; BAD BUGS; SEQUENCE; RESISTANCE; STRAIN AB Acinetobacter baumannii is a Gram-negative bacterial pathogen notorious for causing serious nosocomial infections that resist antibiotic therapy. Research to identify factors responsible for the pathogen's success has been limited by the resources available for genome-scale experimental studies. This report describes the development of several such resources for Acinetobacter baumannii strain AB5075, a recently characterized wound isolate that is multidrug resistant and displays robust virulence in animal models. We report the completion and annotation of the genome sequence, the construction of a comprehensive ordered transposon mutant library, the extension of high-coverage transposon mutant pool sequencing (Tn-seq) to the strain, and the identification of the genes essential for growth on nutrient-rich agar. These resources should facilitate large-scale genetic analysis of virulence, resistance, and other clinically relevant traits that make Acinetobacter baumannii a formidable public health threat. IMPORTANCE Acinetobacter baumannii is one of six bacterial pathogens primarily responsible for antibiotic-resistant infections that have become the scourge of health care facilities worldwide. Eliminating such infections requires a deeper understanding of the factors that enable the pathogen to persist in hospital environments, establish infections, and resist antibiotics. We present a set of resources that should accelerate genome-scale genetic characterization of these traits for a reference isolate of Acinetobacter baumannii that is highly virulent and representative of current outbreak strains. C1 [Gallagher, Larry A.; Ramage, Elizabeth; Held, Kiara G.; Huse, Holly K.; Manoil, Colin] Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA. [Weiss, Eli J.; Radey, Matthew; Hayden, Hillary S.; Brittnacher, Mitchell J.] Univ Washington, Dept Microbiol, Seattle, WA 98195 USA. [Zurawski, Daniel V.] Walter Reed Army Inst Res, Dept Wound Infect, Silver Spring, MD USA. RP Gallagher, LA (reprint author), Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA. EM lg@u.washington.edu; manoil@u.washington.edu OI Zurawski, Daniel/0000-0002-7920-5601 FU Walter Reed Army Institute of Research (WRAIR) via U.S. Army [W81XWH-12-C-0281]; National Institute of Allergy and Infectious Diseases (NIAID) at the National Institutes of Health [U54AI057141]; NIAID [U19AI107775]; Military Infectious Diseases Research Program; Defense Medical Research and Development Program FX The construction of the ordered mutant library was supported by the Walter Reed Army Institute of Research (WRAIR) via U.S. Army contract number W81XWH-12-C-0281 and by grant U54AI057141 from the National Institute of Allergy and Infectious Diseases (NIAID) at the National Institutes of Health. The genome sequencing, annotation, and analysis of essential genes were supported by grant U19AI107775 from NIAID. D.V.Z. and the Army contract listed above were supported by multiple grants from the Military Infectious Diseases Research Program and the Defense Medical Research and Development Program. NR 71 TC 15 Z9 16 U1 0 U2 15 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0021-9193 EI 1098-5530 J9 J BACTERIOL JI J. Bacteriol. PD JUN PY 2015 VL 197 IS 12 BP 2027 EP 2035 DI 10.1128/JB.00131-15 PG 9 WC Microbiology SC Microbiology GA CI3AI UT WOS:000354619400007 PM 25845845 ER PT J AU Mader, TH Gibson, CR Lee, AG Patel, NB Hart, SF Pettit, DR AF Mader, Thomas H. Gibson, C. Robert Lee, Andrew G. Patel, Nimesh B. Hart, Steven F. Pettit, Donald R. TI Unilateral Loss of Spontaneous Venous Pulsations in an Astronaut SO JOURNAL OF NEURO-OPHTHALMOLOGY LA English DT Letter ID DURATION SPACE-FLIGHT; OPTIC DISC EDEMA C1 [Mader, Thomas H.] US Army, Cooper Landing, AK 99572 USA. [Gibson, C. Robert] Coastal Eye Associates, Webster, TX USA. [Lee, Andrew G.] Methodist Hosp, Dept Ophthalmol, Houston, TX 77030 USA. [Patel, Nimesh B.] Univ Houston, Univ Eye Inst, Houston, TX USA. [Hart, Steven F.] NASA, Johnson Space Ctr, Space Med, Houston, TX USA. [Pettit, Donald R.] NASA, Johnson Space Ctr, Houston, TX USA. RP Mader, TH (reprint author), US Army, Cooper Landing, AK 99572 USA. NR 5 TC 3 Z9 3 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1070-8022 EI 1536-5166 J9 J NEURO-OPHTHALMOL JI J. Neuro-Ophthal. PD JUN PY 2015 VL 35 IS 2 BP 226 EP 227 PG 2 WC Clinical Neurology; Ophthalmology SC Neurosciences & Neurology; Ophthalmology GA CI7ZO UT WOS:000354986600029 PM 25756457 ER PT J AU Brupbacher, MC Zhang, DJ Buchta, WM Graybeal, ML Rhim, YR Nagle, DC Spicer, JB AF Brupbacher, Michael C. Zhang, Dajie Buchta, William M. Graybeal, Mark L. Rhim, Yo-Rhin Nagle, Dennis C. Spicer, James B. TI Synthesis and characterization of binder-free Cr3C2 coatings on nickel-based alloys for molten fluoride salt corrosion resistance SO JOURNAL OF NUCLEAR MATERIALS LA English DT Article ID COLD SPRAY PROCESS; CARBIDE; REDUCTION AB Under various conditions, chromium carbides appear to be relatively stable in the presence of molten fluoride salts and this suggests that their use in corrosion resistant coatings for fluoride salt environments could be beneficial. One method for producing these coatings is the carburization of sprayed Cr coatings using methane-containing gaseous precursors. This process has been investigated for the synthesis of binder-free chromium carbide coatings on nickel-based alloy substrates for molten fluoride salt corrosion resistance. The effects of the carburization process on coating microstructure have been characterized using X-ray diffraction (XRD) and scanning electron microscopy (SEM) in conjunction with energy dispersive spectroscopy (EDS). Both plasma-sprayed and cold-sprayed Cr coatings have been successfully converted to Cr3C2, with the mechanism of conversion being strongly influenced by the initial porosity in the as-deposited coatings. (C) 2015 Elsevier B.V. All rights reserved. C1 [Brupbacher, Michael C.; Zhang, Dajie; Nagle, Dennis C.; Spicer, James B.] Johns Hopkins Univ, Dept Mat Sci & Engn, Baltimore, MD 21218 USA. [Buchta, William M.; Rhim, Yo-Rhin] Johns Hopkins Univ, Appl Phys Lab, Laurel, MD 20723 USA. [Graybeal, Mark L.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Spicer, JB (reprint author), Johns Hopkins Univ, Dept Mat Sci & Engn, 3400 North Charles St, Baltimore, MD 21218 USA. EM spicer@jhu.edu RI Spicer, James/A-3312-2010 OI Spicer, James/0000-0002-3512-5503 FU U.S. Department of Energy (DOE) through the Nuclear Energy University Program (NEUP) [101630] FX The authors gratefully acknowledge the support of the U.S. Department of Energy (DOE) through the Nuclear Energy University Program (NEUP) Contract No. 101630. NR 20 TC 1 Z9 1 U1 2 U2 20 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-3115 EI 1873-4820 J9 J NUCL MATER JI J. Nucl. Mater. PD JUN PY 2015 VL 461 BP 215 EP 220 DI 10.1016/j.jnucmat.2015.03.017 PG 6 WC Materials Science, Multidisciplinary; Nuclear Science & Technology SC Materials Science; Nuclear Science & Technology GA CI8LN UT WOS:000355023900029 ER PT J AU Molgaard, JJ Auxier, JD Giminaro, AV Oldham, CJ Cook, MT Young, SA Hall, HL AF Molgaard, Joshua J. Auxier, John D., II Giminaro, Andrew V. Oldham, C. J. Cook, Matthew T. Young, Stephen A. Hall, Howard L. TI Development of synthetic nuclear melt glass for forensic analysis SO JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY LA English DT Article DE Debris; Nuclear weapons; Nuclear forensics; Trinitite; Melt glass; Morphology ID LIQUIDUS TEMPERATURE; RADIONUCLIDE DISTRIBUTION; TRINITITE; SYSTEMS; WASTE AB A method for producing synthetic debris similar to the melt glass produced by nuclear surface testing is demonstrated. Melt glass from the first nuclear weapon test (commonly referred to as trinitite) is used as the benchmark for this study. These surrogates can be used to simulate a variety of scenarios and will serve as a tool for developing and validating forensic analysis methods. C1 [Molgaard, Joshua J.; Auxier, John D., II; Giminaro, Andrew V.; Oldham, C. J.; Cook, Matthew T.; Hall, Howard L.] Univ Tennessee, Dept Nucl Engn, Knoxville, TN 37996 USA. [Molgaard, Joshua J.] US Mil Acad, Dept Phys & Nucl Engn, West Point, NY 10996 USA. [Auxier, John D., II; Giminaro, Andrew V.; Hall, Howard L.] Univ Tennessee, RCoE, Knoxville, TN 37996 USA. [Young, Stephen A.] Univ Tennessee, Engn Sci & Mech, Knoxville, TN 37996 USA. [Hall, Howard L.] Univ Tennessee, Inst Nucl Secur, Knoxville, TN 37996 USA. RP Molgaard, JJ (reprint author), US Mil Acad, Dept Phys & Nucl Engn, West Point, NY 10996 USA. EM joshua.molgaard@usma.edu OI Cook, Matthew/0000-0002-3460-5011; Hall, Howard/0000-0002-4080-5159; Auxier II, John /0000-0001-6234-6451 FU Stewardship Science Academic Alliances (SSAA) Program of the National Nuclear Security Administration (NNSA) [R010130125] FX This work was performed under Grant number R010130125 from the Stewardship Science Academic Alliances (SSAA) Program of the National Nuclear Security Administration (NNSA). NR 16 TC 7 Z9 7 U1 1 U2 14 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0236-5731 EI 1588-2780 J9 J RADIOANAL NUCL CH JI J. Radioanal. Nucl. Chem. PD JUN PY 2015 VL 304 IS 3 BP 1293 EP 1301 DI 10.1007/s10967-015-3941-8 PG 9 WC Chemistry, Analytical; Chemistry, Inorganic & Nuclear; Nuclear Science & Technology SC Chemistry; Nuclear Science & Technology GA CH5RX UT WOS:000354094100037 ER PT J AU Ramakrishnan, S Lu, W Laxminarayan, S Wesensten, NJ Rupp, TL Balkin, TJ Reifman, J AF Ramakrishnan, Sridhar Lu, Wei Laxminarayan, Srinivas Wesensten, Nancy J. Rupp, Tracy L. Balkin, Thomas J. Reifman, Jaques TI Can a mathematical model predict an individual's trait-like response to both total and partial sleep loss? SO JOURNAL OF SLEEP RESEARCH LA English DT Article DE biomathematical model; psychomotor vigilance task; sleep-loss phenotype; trait preservation; two-process model ID PERFORMANCE; DEPRIVATION; VIGILANCE; RESTRICTION; CAFFEINE; PVT AB Humans display a trait-like response to sleep loss. However, it is not known whether this trait-like response can be captured by a mathematical model from only one sleep-loss condition to facilitate neurobehavioural performance prediction of the same individual during a different sleep-loss condition. In this paper, we investigated the extent to which the recently developed unified mathematical model of performance (UMP) captured such trait-like features for different sleep-loss conditions. We used the UMP to develop two sets of individual-specific models for 15 healthy adults who underwent two different sleep-loss challenges (order counterbalanced; separated by 2-4weeks): (i) 64h of total sleep deprivation (TSD) and (ii) chronic sleep restriction (CSR) of 7days of 3h nightly time in bed. We then quantified the extent to which models developed using psychomotor vigilance task data under TSD predicted performance data under CSR, and vice versa. The results showed that the models customized to an individual under one sleep-loss condition accurately predicted performance of the same individual under the other condition, yielding, on average, up to 50% improvement over non-individualized, group-average model predictions. This finding supports the notion that the UMP captures an individual's trait-like response to different sleep-loss conditions. C1 [Ramakrishnan, Sridhar; Lu, Wei; Laxminarayan, Srinivas; Reifman, Jaques] US Army Med Res & Mat Command, Dept Def Biotechnol High Performance Comp Softwar, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. [Wesensten, Nancy J.; Rupp, Tracy L.; Balkin, Thomas J.] Walter Reed Army Inst Res, Dept Behav Biol, Silver Spring, MD USA. RP Reifman, J (reprint author), US Army Med Res & Mat Command, DoD Biotechnol High Performance Comp Software App, Telemed & Adv Technol Res Ctr, ATTN MCMR TT, 504 Scott St, Ft Detrick, MD 21702 USA. EM jaques.reifman.civ@mail.mil FU Military Operational Medicine Research Area Directorate of the US Army Medical Research and Materiel Command, Fort Detrick, MD; US Department of Defense Medical Research and Development Program [DMRDP_13200] FX This work was sponsored by the Military Operational Medicine Research Area Directorate of the US Army Medical Research and Materiel Command, Fort Detrick, MD, and by the US Department of Defense Medical Research and Development Program (grant no. DMRDP_13200). The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the US Army or of the US Department of Defense. This paper has been approved for public release with unlimited distribution. NR 20 TC 3 Z9 3 U1 1 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0962-1105 EI 1365-2869 J9 J SLEEP RES JI J. Sleep Res. PD JUN PY 2015 VL 24 IS 3 BP 262 EP 269 DI 10.1111/jsr.12272 PG 8 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA CI5OD UT WOS:000354805600004 PM 25559055 ER PT J AU Spring, MD Lin, JT Manning, JE Vanachayangkul, P Somethy, S Bun, R Se, Y Chann, S Ittiverakul, M Sia-Ngam, P Kuntawunginn, W Arsanok, M Buathong, N Chaorattanakawee, S Gosi, P Ta-Aksorn, W Chanarat, N Sundrakes, S Kong, N Heng, TK Nou, S Teja-Isavadharm, P Pichyangkul, S Phann, ST Balasubramanian, S Juliano, JJ Meshnick, SR Chour, CM Prom, S Lanteri, CA Lon, C Saunders, DL AF Spring, Michele D. Lin, Jessica T. Manning, Jessica E. Vanachayangkul, Pattaraporn Somethy, Sok Bun, Rathvicheth Se, Youry Chann, Soklyda Ittiverakul, Mali Sia-ngam, Piyaporn Kuntawunginn, Worachet Arsanok, Montri Buathong, Nillawan Chaorattanakawee, Suwanna Gosi, Panita Ta-Aksorn, Winita Chanarat, Nitima Sundrakes, Siratchana Kong, Nareth Heng, Thay Kheang Nou, Samon Teja-Isavadharm, Paktiya Pichyangkul, Sathit Phann, Sut Thang Balasubramanian, Sujata Juliano, Jonathan J. Meshnick, Steven R. Chour, Char Meng Prom, Satharath Lanteri, Charlotte A. Lon, Chanthap Saunders, David L. TI Dihydroartemisinin-piperaquine failure associated with a triple mutant including kelch13 C580Y in Cambodia: an observational cohort study SO LANCET INFECTIOUS DISEASES LA English DT Article ID PLASMODIUM-FALCIPARUM MALARIA; ARTEMISININ RESISTANCE MUTATIONS; WESTERN CAMBODIA; SOUTHEAST-ASIA; EFFICACY; ARTESUNATE; SUSCEPTIBILITY; CLEARANCE; EMERGENCE AB Background Dihydroartemisinin-piperaquine has been adopted as first-line artemisinin combination therapy (ACT) for multidrug-resistant Plasmodium falciparum malaria in Cambodia because of few remaining alternatives. We aimed to assess the efficacy of standard 3 day dihydroartemisinin-piperaquine treatment of uncomplicated P falciparum malaria, with and without the addition of primaquine, focusing on the factors involved in drug resistance. Methods In this observational cohort study, we assessed 107 adults aged 18-65 years presenting to Anlong Veng District Hospital, Oddar Meanchey Province, Cambodia, with uncomplicated P falciparum or mixed P falciparum/Plasmodium vivax infection of between 1000 and 200 000 parasites per mu L of blood, and participating in a randomised clinical trial in which all had received dihydroartemisinin-piperaquine for 3 days, after which they had been randomly allocated to receive either primaquine or no primaquine. The trial was halted early due to poor dihydroartemisinin-piperaquine efficacy, and we assessed day 42 PCR-corrected therapeutic efficacy (proportion of patients with recurrence at 42 days) and evidence of drug resistance from the initial cohort. We did analyses on both the intention to treat (ITT), modified ITT (withdrawals, losses to follow-up, and those with secondary outcomes [eg, new non-recrudescent malaria infection] were censored on the last day of follow-up), and per-protocol populations of the original trial. The original trial was registered with ClinicalTrials.gov, number NCT01280162. Findings Between Dec 10, 2012, and Feb 18, 2014, we had enrolled 107 patients in the original trial. Enrolment was voluntarily halted on Feb 16, 2014, before reaching planned enrolment (n=150) because of poor efficacy. We had randomly allocated 50 patients to primaquine and 51 patients to no primaquine groups. PCR-adjusted Kaplan-Meier risk of P falciparum 42 day recrudescence was 54% (95% CI 45-63) in the modified ITT analysis population. We found two kelch13 propeller gene mutations associated with artemisinin resistance-a non-synonymous Cys580Tyr substitution in 70 (65%) of 107 participants, an Arg539Thr substitution in 33 (31%), and a wild-type parasite in four (4%). Unlike Arg539Thr, Cys580Tyr was accompanied by two other mutations associated with extended parasite clearance (MAL10:688956 and MAL13:1718319). This combination triple mutation was associated with a 5.4 times greater risk of treatment failure (hazard ratio 5.4 [95% CI 2.4-12]; p<0.0001) and higher piperaquine 50% inhibitory concentration (triple mutant 34 nM [28-41]; non-triple mutant 24 nM [1-27]; p=0.003) than other infections had. The drug was well tolerated, with gastrointestinal symptoms being the most common complaints. Interpretation The dramatic decline in efficacy of dihydroartemisinin-piperaquine compared with what was observed in a study at the same location in 2010 was strongly associated with a new triple mutation including the kelch13 Cys580Tyr substitution. 3 days of artemisinin as part of an artemisinin combination therapy regimen might be insufficient. Strict regulation and monitoring of antimalarial use, along with non-pharmacological approaches to malaria resistance containment, must be integral parts of the public health response to rapidly accelerating drug resistance in the region. C1 [Spring, Michele D.; Manning, Jessica E.; Vanachayangkul, Pattaraporn; Se, Youry; Ittiverakul, Mali; Sia-ngam, Piyaporn; Kuntawunginn, Worachet; Arsanok, Montri; Buathong, Nillawan; Chaorattanakawee, Suwanna; Gosi, Panita; Ta-Aksorn, Winita; Chanarat, Nitima; Sundrakes, Siratchana; Teja-Isavadharm, Paktiya; Pichyangkul, Sathit; Lanteri, Charlotte A.; Lon, Chanthap; Saunders, David L.] Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand. [Se, Youry; Chann, Soklyda; Nou, Samon; Lon, Chanthap] Armed Forces Res Inst Med Sci, Phnom Penh, Cambodia. [Somethy, Sok; Prom, Satharath] Royal Cambodian Armed Forces, Phnom Penh, Cambodia. [Bun, Rathvicheth; Kong, Nareth; Heng, Thay Kheang; Phann, Sut Thang; Chour, Char Meng] Natl Ctr Parasitol Entomol & Malaria Control, Phnom Penh, Cambodia. [Lin, Jessica T.; Balasubramanian, Sujata; Juliano, Jonathan J.; Meshnick, Steven R.] Univ N Carolina, Chapel Hill, NC USA. RP Saunders, DL (reprint author), Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand. EM david.saunders@afrims.org FU Armed Forces Health Surveillance Center/Global Emerging Infections Surveillance and Response System; Military Infectious Disease Research Program; American Society of Tropical Medicine and Hygiene/Burroughs Wellcome Fund; National Institute of Allergy and Infectious Diseases FX Armed Forces Health Surveillance Center/Global Emerging Infections Surveillance and Response System, Military Infectious Disease Research Program, National Institute of Allergy and Infectious Diseases, and American Society of Tropical Medicine and Hygiene/Burroughs Wellcome Fund. NR 36 TC 51 Z9 51 U1 0 U2 8 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1473-3099 EI 1474-4457 J9 LANCET INFECT DIS JI Lancet Infect. Dis. PD JUN PY 2015 VL 15 IS 6 BP 683 EP 691 DI 10.1016/S1473-3099(15)70049-6 PG 9 WC Infectious Diseases SC Infectious Diseases GA CI3HI UT WOS:000354638000033 PM 25877962 ER PT J AU Heller, D Arnold, JE Klein, N Tanenhaus, MK AF Heller, Daphna Arnold, Jennifer E. Klein, Natalie Tanenhaus, Michael K. TI Inferring Difficulty: Flexibility in the Real-time Processing of Disfluency SO LANGUAGE AND SPEECH LA English DT Article DE Disfluency; reference; inferences; artificial words; eye-tracking ID SPONTANEOUS SPEECH; FILLED PAUSES; LANGUAGE COMPREHENSION; SPOKEN LANGUAGE; DISCOURSE; UH; INFORMATION; LISTENERS; PROSODY; MEMORY AB Upon hearing a disfluent referring expression, listeners expect the speaker to refer to an object that is previously unmentioned, an object that does not have a straightforward label, or an object that requires a longer description. Two visual-world eye-tracking experiments examined whether listeners directly associate disfluency with these properties of objects, or whether disfluency attribution is more flexible and involves situation-specific inferences. Since in natural situations reference to objects that do not have a straightforward label or that require a longer description is correlated with both production difficulty and with disfluency, we used a mini-artificial lexicon to dissociate difficulty from these properties, building on the fact that recently learned names take longer to produce than existing words in one's mental lexicon. The results demonstrate that disfluency attribution involves situation-specific inferences; we propose that in new situations listeners spontaneously infer what may cause production difficulty. However, the results show that these situation-specific inferences are limited in scope: listeners assessed difficulty relative to their own experience with the artificial names, and did not adapt to the assumed knowledge of the speaker. C1 [Heller, Daphna] Univ Toronto, Dept Linguist, Toronto, ON M5S 3G3, Canada. [Arnold, Jennifer E.] Univ N Carolina, Dept Psychol, Chapel Hill, NC USA. [Klein, Natalie] US Army Med Res & Mat Command, Off Res Protect, Ft Detrick, MD USA. [Tanenhaus, Michael K.] Univ Rochester, Dept Brain & Cognit Sci, Rochester, NY 14627 USA. RP Heller, D (reprint author), Univ Toronto, Dept Linguist, 100 St George St, Toronto, ON M5S 3G3, Canada. EM daphna.heller@utoronto.ca FU NSF [BCS-0745627]; NIH [HD-27206] FX This work was partially supported by NSF grant BCS-0745627 to J Arnold and NIH grant HD-27206 to MK Tanenhaus. The views expressed in this article are those of the author(s) and do not reflect the official policy of the Department of the Army, the Department of Defense, or the US Government. NR 35 TC 0 Z9 0 U1 3 U2 11 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0023-8309 EI 1756-6053 J9 LANG SPEECH JI Lang. Speech PD JUN PY 2015 VL 58 IS 2 BP 190 EP 203 DI 10.1177/0023830914528107 PG 14 WC Audiology & Speech-Language Pathology; Linguistics; Psychology, Experimental SC Audiology & Speech-Language Pathology; Linguistics; Psychology GA CI6JJ UT WOS:000354864700004 PM 26677642 ER PT J AU Torres, I Torres, LN Valdez, C Salgado, C Cap, AP Dubick, MA AF Torres Filho, I. Torres, L. N. Valdez, C. Salgado, C. Cap, A. P. Dubick, M. A. TI IN VIVO EVALUATION OF PLATELET FUNCTION IN RATS USING CONFOCAL INTRAVITAL VIDEOMICROSCOPY SO SHOCK LA English DT Meeting Abstract CT 38th Annual Conference of the Shock-Society on Shock CY JUN 06-09, 2015 CL Denver, CO SP Shock Soc C1 [Torres Filho, I.; Torres, L. N.; Valdez, C.; Salgado, C.; Cap, A. P.; Dubick, M. A.] US Army Inst Surg Res, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2015 VL 43 IS 6 SU 1 MA P18 BP 39 EP 40 PG 2 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA CI4QC UT WOS:000354736000056 ER PT J AU Darlington, DN Wu, X Cap, AP AF Darlington, D. N. Wu, X. Cap, A. P. TI THE PATHOPHYSIOLOGY OF POLYTRAUMA AND HEMORRHAGE IN RATS SO SHOCK LA English DT Meeting Abstract CT 38th Annual Conference of the Shock-Society on Shock CY JUN 06-09, 2015 CL Denver, CO SP Shock Soc C1 [Darlington, D. N.; Wu, X.; Cap, A. P.] US Army Inst Surg Res, San Antonio, TX USA. [Darlington, D. N.; Wu, X.; Cap, A. P.] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX 78229 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2015 VL 43 IS 6 SU 1 MA P25 BP 42 EP 42 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA CI4QC UT WOS:000354736000063 ER PT J AU Lewis, AM Wu, X Darlington, DN Cap, AP Schwacha, MG AF Lewis, A. M. Wu, X. Darlington, D. N. Cap, A. P. Schwacha, M. G. TI TOLL-LIKE RECEPTOR (TLR) STIMULATION INHIBITS COLLAGEN-INDUCED ACTIVATION OF PLATELETS SO SHOCK LA English DT Meeting Abstract CT 38th Annual Conference of the Shock-Society on Shock CY JUN 06-09, 2015 CL Denver, CO SP Shock Soc C1 [Lewis, A. M.; Wu, X.; Darlington, D. N.; Cap, A. P.; Schwacha, M. G.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Wu, X.; Darlington, D. N.; Cap, A. P.; Schwacha, M. G.] US Army Inst Surg Res, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2015 VL 43 IS 6 SU 1 MA P32 BP 45 EP 45 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA CI4QC UT WOS:000354736000070 ER PT J AU Parida, BK Prat, N Montgomery, RK Wu, X Darlington, DN Cap, AP AF Parida, B. K. Prat, N. Montgomery, R. K. Wu, X. Darlington, D. N. Cap, A. P. TI CHARACTERIZATION OF MICROVESICLES IN RAT MODEL OF TRAUMA AND HEMORRHAGE SO SHOCK LA English DT Meeting Abstract CT 38th Annual Conference of the Shock-Society on Shock CY JUN 06-09, 2015 CL Denver, CO SP Shock Soc C1 [Parida, B. K.; Montgomery, R. K.; Wu, X.; Darlington, D. N.; Cap, A. P.] US Army Inst Surg Res, San Antonio, TX USA. [Prat, N.] French Armed Forces Inst Biomed Res IRBA, Paris, France. RI PRAT, Nicolas/R-4213-2016 NR 0 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2015 VL 43 IS 6 SU 1 MA P76 BP 62 EP 63 PG 2 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA CI4QC UT WOS:000354736000113 ER PT J AU Lusczek, ER Dubick, MA Beilman, G AF Lusczek, E. R. Dubick, M. A. Beilman, G. TI METABOLIC MARKERS OF INJURY AND MORTALITY IN COMBAT-RELATED TRAUMA SO SHOCK LA English DT Meeting Abstract CT 38th Annual Conference of the Shock-Society on Shock CY JUN 06-09, 2015 CL Denver, CO SP Shock Soc C1 [Lusczek, E. R.; Beilman, G.] Univ Minnesota, Minneapolis, MN USA. [Dubick, M. A.] US Army Inst Surg Res, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2015 VL 43 IS 6 SU 1 MA P80 BP 64 EP 64 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA CI4QC UT WOS:000354736000117 ER PT J AU Fryer, DM Macko, AR Crossland, R Fedyk, CG Scherer, MR Cap, AP Sheppard, FR AF Fryer, D. M. Macko, A. R. Crossland, R. Fedyk, C. G. Scherer, M. R. Cap, A. P. Sheppard, F. R. TI TRAUMA-INDUCED COAGULOPATHY IN A NON-HUMAN PRIMATE (RHESUS MACAQUE) MODEL OF UNCONTROLLED HEMORRHAGE SO SHOCK LA English DT Meeting Abstract CT 38th Annual Conference of the Shock-Society on Shock CY JUN 06-09, 2015 CL Denver, CO SP Shock Soc C1 [Fryer, D. M.; Macko, A. R.; Crossland, R.; Sheppard, F. R.] Naval Med Res Unit San Antonio, San Antonio, TX USA. [Fedyk, C. G.; Scherer, M. R.; Cap, A. P.] US Army Inst Surg Res, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2015 VL 43 IS 6 SU 1 MA P94 BP 71 EP 71 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA CI4QC UT WOS:000354736000131 ER PT J AU Crossland, R Macko, AR Paredes, RM Vernon, PJ Fryer, DM Cap, AP Sheppard, FR AF Crossland, R. Macko, A. R. Paredes, R. M. Vernon, P. J. Fryer, D. M. Cap, A. P. Sheppard, F. R. TI THE EVALUATION OF A PLATELET DERIVED HEMOSTATIC AGENT TO REDUCE BLOOD LOSS IN A NON-HUMAN PRIMATE (RHESUS MACAQUE) MODEL OF UNCONTROLLED HEMORRHAGE SO SHOCK LA English DT Meeting Abstract CT 38th Annual Conference of the Shock-Society on Shock CY JUN 06-09, 2015 CL Denver, CO SP Shock Soc C1 [Crossland, R.; Macko, A. R.; Paredes, R. M.; Vernon, P. J.; Fryer, D. M.; Sheppard, F. R.] Naval Med Res Unit San Antonio, San Antonio, TX USA. [Cap, A. P.] US Army Inst Surg Res, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2015 VL 43 IS 6 SU 1 MA P97 BP 72 EP 72 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA CI4QC UT WOS:000354736000134 ER PT J AU Torres, LN Salgado, C Valdez, C Sondeen, JL Dubick, MA Torres, I AF Torres, L. N. Salgado, C. Valdez, C. Sondeen, J. L. Dubick, M. A. Torres Filho, I. TI OPTIMIZING COMBAT CAUSUALTY CARE: MODULATION OF MICROVASCULAR ENDOTHELIUM BY RESUSCITATION FLUIDS AFTER SEVERE BLOOD LOSS IN RATS SO SHOCK LA English DT Meeting Abstract CT 38th Annual Conference of the Shock-Society on Shock CY JUN 06-09, 2015 CL Denver, CO SP Shock Soc C1 [Torres, L. N.; Salgado, C.; Valdez, C.; Sondeen, J. L.; Dubick, M. A.; Torres Filho, I.] US Army Inst Surg Res, San Antonio, TX USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2015 VL 43 IS 6 SU 1 MA P102 BP 74 EP 75 PG 2 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA CI4QC UT WOS:000354736000139 ER PT J AU Cardenas, JC Cap, AP Huby, M Baer, LA Matijevic, N Cotton, B Holcomb, J Wade, C AF Cardenas, J. C. Cap, A. P. Huby, M. Baer, L. A. Matijevic, N. Cotton, B. Holcomb, J. Wade, C. TI PLASMA RESUSCITATION PROMOTES COAGULATION HOMEOSTASIS FOLLOWING SHOCK-INDUCED HYPERCOAGULABILITY SO SHOCK LA English DT Meeting Abstract CT 38th Annual Conference of the Shock-Society on Shock CY JUN 06-09, 2015 CL Denver, CO SP Shock Soc C1 [Cardenas, J. C.; Huby, M.; Baer, L. A.; Matijevic, N.; Cotton, B.; Holcomb, J.; Wade, C.] Univ Texas Hlth Sci Ctr Houston, Houston, TX 77030 USA. [Cap, A. P.] US Army Inst Surg Res, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2015 VL 43 IS 6 SU 1 MA P103 BP 75 EP 75 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA CI4QC UT WOS:000354736000140 ER PT J AU Pidcoke, HF Herzig, MC Schaffer, BS Fedyk, CG Chung, KK Cap, AP AF Pidcoke, H. F. Herzig, M. C. Schaffer, B. S. Fedyk, C. G. Chung, K. K. Cap, A. P. TI PLATELET DYSFUNCTION IS POORLY RECOGNIZED BY CLINICIANS DURING BURN SURGERY SO SHOCK LA English DT Meeting Abstract CT 38th Annual Conference of the Shock-Society on Shock CY JUN 06-09, 2015 CL Denver, CO SP Shock Soc C1 [Pidcoke, H. F.; Herzig, M. C.; Schaffer, B. S.; Fedyk, C. G.; Chung, K. K.; Cap, A. P.] US Army Inst Surg Res, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2015 VL 43 IS 6 SU 1 MA P152 BP 96 EP 96 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA CI4QC UT WOS:000354736000189 ER PT J AU Martini, WZ Rodriguez, C Richardson, J Cap, AP Dubick, MA AF Martini, W. Z. Rodriguez, C. Richardson, J. Cap, A. P. Dubick, M. A. TI EFFECTS OF PLATELET APHERESIS ON COAGULATION IN PIGS SO SHOCK LA English DT Meeting Abstract CT 38th Annual Conference of the Shock-Society on Shock CY JUN 06-09, 2015 CL Denver, CO SP Shock Soc C1 [Martini, W. Z.; Rodriguez, C.; Richardson, J.; Cap, A. P.; Dubick, M. A.] US Army Inst Surg Res, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2015 VL 43 IS 6 SU 1 MA P170 BP 104 EP 105 PG 2 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA CI4QC UT WOS:000354736000207 ER PT J AU Dubick, MA Prince, M Polykratis, IA De Guzman, R Cap, AP Sondeen, JL AF Dubick, M. A. Prince, M. Polykratis, I. A. De Guzman, R. Cap, A. P. Sondeen, J. L. TI USE OF EARLY TRANEXAMIC ACID TREATMENT IN SWINE SUBJECTED TO UNCONTROLLED HEMORRHAGE SO SHOCK LA English DT Meeting Abstract CT 38th Annual Conference of the Shock-Society on Shock CY JUN 06-09, 2015 CL Denver, CO SP Shock Soc C1 [Dubick, M. A.; Prince, M.; Polykratis, I. A.; De Guzman, R.; Cap, A. P.; Sondeen, J. L.] US Army Inst Surg Res, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2015 VL 43 IS 6 SU 1 MA P172 BP 105 EP 105 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA CI4QC UT WOS:000354736000209 ER PT J AU Rani, M Zhang, Q Holloway, TL Sordo, S Schwacha, MG AF Rani, M. Zhang, Q. Holloway, T. L. Sordo, S. Schwacha, M. G. TI MITOCHONDRIAL DAMAGE ASSOCIATED MOLECULAR PATTERNS (DAMPS) AND GAMMA DELTA T-CELLS: POTENTIAL EFFECTORS IN THE WOUND HEALING RESPONSE SO SHOCK LA English DT Meeting Abstract CT 38th Annual Conference of the Shock-Society on Shock CY JUN 06-09, 2015 CL Denver, CO SP Shock Soc C1 [Rani, M.; Zhang, Q.; Holloway, T. L.; Sordo, S.; Schwacha, M. G.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Schwacha, M. G.] US Army Inst Surg Res, Houston, TX USA. NR 0 TC 0 Z9 0 U1 2 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2015 VL 43 IS 6 SU 1 MA P185 BP 111 EP 111 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA CI4QC UT WOS:000354736000222 ER PT J AU Liu, NT Holcomb, JB Wade, CE Salinas, J AF Liu, Nehemiah T. Holcomb, John B. Wade, Charles E. Salinas, Jose TI IMPROVING THE PREDICTION OF MORTALITY AND THE NEED FOR LIFE-SAVING INTERVENTIONS IN TRAUMA PATIENTS USING STANDARD VITAL SIGNS WITH HEART-RATE VARIABILITY AND COMPLEXITY SO SHOCK LA English DT Article DE Mortality; life-saving interventions; heart rate complexity; heart rate variability; trauma ID PERIOD VARIABILITY; HELICOPTERS; IMPACT; NOISE; SHOCK AB The goal of this study was to determine the effectiveness of using traditional and new vital signs (heart rate variability and complexity [HRV, HRC]) for predicting mortality and the need for life-saving interventions (LSIs) in prehospital trauma patients. Our hypothesis was that statistical regression models using traditional and new vital signs would be superior in predictive performance over models using standard vital signs alone. This study involved 108 prehospital trauma patients transported from the point of injury via helicopter. Heart rate variability and HRC were calculated using criterion standard R-R interval sequences manually verified from the patients' electrocardiograms. Means and standard deviations for vital signs, HRV, HRC, and Glasgow coma scale (GCS) scores were obtained for nonsurvivors versus survivors and LSI versus non-LSI patient groups and then compared using Wilcoxon statistical tests. Receiver-operating characteristic curves were also obtained to compare different regression models for predicting mortality and the need for LSIs. Seventeen patients (16%) died. Eighty-two patients (76%) received a total of 142 LSIs. Receiver-operating characteristic curves demonstrated better prediction of mortality and LSI needs using heart rate and HRC (area under the curve [AUC]; AUCs, 0.86 and 0.86) than using heart rate alone (AUCs, 0.79 and 0.57). Likewise, receiver-operating characteristic curves demonstrated better prediction using total GCS score and HRC (AUCs, 0.82 and 0.97) than using total GCS score (AUCs, 0.81 and 0.91). Similar results were obtained for heart rate and HRV (AUCs, 0.86 and 0.73). The major implication of this study was that traditional and new vital signs (HRV and HRC) should be used simultaneously to improve prediction of mortality and the need for LSIs in prehospital trauma patients during all echelons of trauma care. Improvements in the timely use and diagnostic accuracy of transportable vital signs monitors will require use of traditional and new vital signs from the trauma patient cohort. C1 [Liu, Nehemiah T.; Salinas, Jose] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Holcomb, John B.; Wade, Charles E.] Univ Texas Hlth Sci Ctr Houston, Dept Surg, Ctr Translat Injury Res, Houston, TX 77030 USA. RP Liu, NT (reprint author), US Army Inst Surg Res, 3698 Chambers Pass, Jbsa Ft Sam Houston, TX 78234 USA. EM nehemiah.liu@us.army.mil FU National Trauma Institute; Combat Casualty Care Research Program; State of Texas Emerging Technology Fund FX This work was supported by the National Trauma Institute, the Combat Casualty Care Research Program, and the State of Texas Emerging Technology Fund. NR 25 TC 8 Z9 8 U1 1 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2015 VL 43 IS 6 BP 549 EP 555 DI 10.1097/SHK.0000000000000356 PG 7 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA CI4PO UT WOS:000354734300005 PM 25692260 ER PT J AU Rani, M Zhang, Q Oppeltz, RF Schwacha, MG AF Rani, Meenakshi Zhang, Qiong Oppeltz, Richard F. Schwacha, Martin G. TI GAMMA DELTA T CELLS REGULATE INFLAMMATORY CELL INFILTRATION OF THE LUNG AFTER TRAUMA-HEMORRHAGE SO SHOCK LA English DT Article DE Injury; receptors; inflammation; cytokines ID SUPPRESSOR-CELLS; EARLY ACTIVATION; INJURY; SKIN; LYMPHOCYTES; RECRUITMENT; BURN; MICE; FIBROSIS; IL-17 AB Trauma-hemorrhage (TH) promotes acute lung injury (ALI) and other pulmonary-related complications in part through an exaggerated inflammatory response. Studies have implicated gamma delta T cells in the development of inflammatory complications after major injury; however, it is unknown whether gamma delta T cells play a role in the development of ALI after TH. To study this, C57BL/6 wild-type (WT) and % TCR-/- mice were subjected to TH or sham treatment. Lung injury was clearly evident at 2 h after TH, as evidenced by increased lung permeability, myeloperoxidase levels, and proinflammatory cytokine/chemokine levels (interleukin-1 beta [IL-1 beta], IL-6, IL-10, keratinocyte chemokine, macrophage inflammatory protein 1 alpha, macrophage inflammatory protein 1 beta, and regulated upon activation normal T-cell expressed, secreted chemokine). Phenotypic analysis of lung cells showed an increase in T-cell numbers after TH. The vast majority of these cells were alpha beta T cells, irrespective of injury. Although gamma delta T cells were a small percentage of the total T-cell infiltrate, their numbers did increase after injury. In mice lacking gamma delta T cells (% TCR-/- mice), TH-induced T-cell infiltration of the lung was markedly attenuated, whereas infiltration of other inflammatory cells was increased (i.e., monocytes, granulocytes, and myeloid-derived suppressor cells). In conclusion, these findings suggest that gamma delta T cells regulated the infiltration of the lung with inflammatory cells after injury. C1 [Rani, Meenakshi; Zhang, Qiong; Oppeltz, Richard F.; Schwacha, Martin G.] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX 78229 USA. [Schwacha, Martin G.] US Army Inst Surg Res, Ft Sam Houston, TX USA. RP Schwacha, MG (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, Mail Code 7740,7703 Floyd Curl Dr, San Antonio, TX 78229 USA. EM schwacha@uthscsa.edu FU University of Texas Health Science Center at San Antonio Department of Surgery FX This work was supported by funding from the University of Texas Health Science Center at San Antonio Department of Surgery. NR 29 TC 3 Z9 3 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2015 VL 43 IS 6 BP 589 EP 597 DI 10.1097/SHK.0000000000000358 PG 9 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA CI4PO UT WOS:000354734300011 PM 25692261 ER PT J AU Guo, RJ Ward, CL Davidson, JM Duvall, CL Wenke, JC Guelcher, SA AF Guo, Ruijing Ward, Catherine L. Davidson, Jeffrey M. Duvall, Craig L. Wenke, Joseph C. Guelcher, Scott A. TI A transient cell-shielding method for viable MSC delivery within hydrophobic scaffolds polymerized in situ SO BIOMATERIALS LA English DT Article DE Cell encapsulation; Polyurethane; Wound healing; Polymerisation; Mesenchymal stem cell; Polyorthoester ID MOLECULAR-WEIGHT DISTRIBUTION; CALCIUM-PHOSPHATE CEMENT; MECHANICAL-PROPERTIES; ALGINATE HYDROGELS; OXIDIZED ALGINATE; REACTION-KINETICS; STEM-CELLS; TISSUE; DEGRADATION; REGENERATION AB Cell-based therapies have emerged as promising approaches for regenerative medicine. Hydrophobic poly(ester urethane)s offer the advantages of robust mechanical properties, cell attachment without the use of peptides, and controlled degradation by oxidative and hydrolytic mechanisms. However, the application of injectable hydrophobic polymers to cell delivery is limited by the challenges of protecting cells from reaction products and creating a macroporous architecture post-cure. We designed injectable carriers for cell delivery derived from reactive, hydrophobic polyisocyanate and polyester triol precursors. To overcome cell death caused by reaction products from in situ polymerization, we encapsulated bone marrow-derived stem cells (BMSCs) in fastdegrading, oxidized alginate beads prior to mixing with the hydrophobic precursors. Cells survived the polymerization at >70% viability, and rapid dissolution of oxidized alginate beads after the scaffold cured created interconnected macropores that facilitated cellular adhesion to the scaffold in vitro. Applying this injectable system to deliver BMSCs to rat excisional skin wounds showed that the scaffolds supported survival of transplanted cells and infiltration of host cells, which improved new tissue formation compared to both implanted, pre-formed scaffolds seeded with cells and acellular controls. Our design is the first to enable injectable delivery of settable, hydrophobic scaffolds where cell encapsulation provides a mechanism for both temporary cytoprotection during polymerization and rapid formation of macropores post-polymerization. This simple approach provides potential advantages for cell delivery relative to hydrogel technologies, which have weaker mechanical properties and require incorporation of peptides to achieve cell adhesion and degradability. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Guo, Ruijing; Guelcher, Scott A.] Vanderbilt Univ, Dept Chem & Biomol Engn, Nashville, TN 37235 USA. [Guo, Ruijing; Guelcher, Scott A.] Vanderbilt Univ, Med Ctr, Ctr Bone Biol, Nashville, TN 37235 USA. [Ward, Catherine L.; Wenke, Joseph C.] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Davidson, Jeffrey M.] Vanderbilt Univ, Dept Pathol Microbiol & Immunol, Nashville, TN 37235 USA. [Davidson, Jeffrey M.] VA Tennessee Valley Healthcare Syst, Res Serv, Nashville, TN USA. [Duvall, Craig L.; Guelcher, Scott A.] Vanderbilt Univ, Dept Biomed Engn, Nashville, TN 37235 USA. RP Guelcher, SA (reprint author), Vanderbilt Univ, Dept Chem & Biomol Engn, 221 Kirkland Hall, Nashville, TN 37235 USA. EM scott.guelcher@vanderbilt.edu FU Orthopaedic Extremity Trauma Research Program [DOD W81XWH-07-1-0211]; National Institute of Arthritis and Musculoskeletal and Skin Diseases [AR056138]; Department of Veterans Affairs FX The authors acknowledge Frank Rauh at FMC Novamatrix for helpful discussions on preparation of partially oxidized alginate. Financial support was provided by the Orthopaedic Extremity Trauma Research Program (DOD W81XWH-07-1-0211), the National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR056138), and the Department of Veterans Affairs. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or the Department of Veterans Affairs. NR 54 TC 7 Z9 7 U1 6 U2 55 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0142-9612 EI 1878-5905 J9 BIOMATERIALS JI Biomaterials PD JUN PY 2015 VL 54 BP 21 EP 33 DI 10.1016/j.biomaterials.2015.03.010 PG 13 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA CI2QD UT WOS:000354591200003 PM 25907036 ER PT J AU Singh, VP Cui, HJ Byrd, A AF Singh, Vijay P. Cui, Huijuan Byrd, Aaron TI Sediment Graphs Based on Entropy Theory SO JOURNAL OF HYDROLOGIC ENGINEERING LA English DT Article DE Entropy theory; Sediment yield; Sediment discharge; Unit hydrograph; Unit sediment graph ID STATISTICAL MECHANICS; INFORMATION THEORY; MAXIMUM-ENTROPY; EROSION; YIELD; MODEL; PREDICTION; EQUATIONS AB Using the entropy theory, this paper derives an instantaneous unit sediment graph (IUSG or USG) to determine sediment discharge and the relation between sediment yield and runoff volume. The derivation of IUSG requires an expression of the effective sediment erosion intensity whose relation with rainfall is revisited. The entropy theory provides an efficient way to estimate the parameters involved in the derivations. Sediment discharge is also computed using the instantaneous unit hydrograph (IUH), which can also be derived using the entropy theory. This method works as well as the IUSG method, especially when the peak sediment discharge and peak runoff occur at the same time. The entropy theory yields the probability distribution of sediment yield and of sediment discharge, which can then be used to estimate uncertainty in sediment yield prediction. C1 [Singh, Vijay P.] Texas A&M Univ, Dept Civil & Environm Engn, Dept Biol & Agr Engn, Water Engn, College Stn, TX 77843 USA. [Cui, Huijuan] Texas A&M Univ, Water Management & Hydrol Sci Program, College Stn, TX 77843 USA. [Byrd, Aaron] US Army, Corps Engineers, Hydrol Syst Branch, Coastal & Hydraul Lab,Engineer Res Dev Ctr, Vicksburg, MS 39181 USA. RP Cui, HJ (reprint author), Texas A&M Univ, Water Management & Hydrol Sci Program, College Stn, TX 77843 USA. EM cui.huijuan@gmail.com NR 39 TC 2 Z9 2 U1 0 U2 8 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1084-0699 EI 1943-5584 J9 J HYDROL ENG JI J. Hydrol. Eng. PD JUN PY 2015 VL 20 IS 6 SI SI AR C4014004 DI 10.1061/(ASCE)HE.1943-5584.0001068 PG 10 WC Engineering, Civil; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA CI2AU UT WOS:000354547700009 ER PT J AU Costley, RD Diaz-Alvarez, H McKenna, MH Jordan, AM AF Costley, R. Daniel Diaz-Alvarez, Henry McKenna, Mihan H. Jordan, Anna M. TI Vibration and Acoustic Analysis of Trussed Railroad Bridge Under Moving Loads SO JOURNAL OF VIBRATION AND ACOUSTICS-TRANSACTIONS OF THE ASME LA English DT Article ID TRAINS AB A finite element (FE) model was developed for a Pratt truss railroad bridge located at Ft. Leonard Wood, MO. This model was used to investigate the vibration responses of a bridge under vehicle loading. Modeling results were obtained for a single axle with two wheels traversing the bridge at different speeds. The current model does not include the effects of vehicle suspension. Superposition of multiple axles was used to represent a locomotive transiting the bridge. The output of the vibration response was used as an input to an acoustic FE model to determine which vibrational modes radiate infrasound. The vibration and acoustic models of the railroad bridge will be reviewed, and results from the analysis will be presented. Measurements from an accelerometer mounted on the bridge agree reasonably well with model results. Infrasound could potentially be used to remotely provide information on the capacity and number of vehicles traversing the bridge and to monitor the bridge for significant structural damage. C1 [Costley, R. Daniel; Diaz-Alvarez, Henry; McKenna, Mihan H.; Jordan, Anna M.] US Army, Corps Engineers, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Costley, RD (reprint author), US Army, Corps Engineers, Engn Res & Dev Ctr, 3909 Halls Ferry Rd,CEERD GS S 5014, Vicksburg, MS 39180 USA. EM dan.costley@usace.army.mil; henry.diaz-alvarez@usace.army.mil; mihan.h.mckenna@usace.army.mil; anna.m.jordan@usace.army.mil FU U.S. Army Engineer Research and Development Center FX This work was supported by the U.S. Army Engineer Research and Development Center. Permission to publish was granted by Director, Geotechnical & Structures Laboratory. NR 18 TC 0 Z9 0 U1 1 U2 11 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 1048-9002 EI 1528-8927 J9 J VIB ACOUST JI J. Vib. Acoust.-Trans. ASME PD JUN PY 2015 VL 137 IS 3 AR 031009 DI 10.1115/1.4029213 PG 10 WC Acoustics; Engineering, Mechanical; Mechanics SC Acoustics; Engineering; Mechanics GA CH4XX UT WOS:000354038400009 ER PT J AU Sanghavi, BJ Gadhari, NS Kalambate, PK Karna, SP Srivastava, AK AF Sanghavi, Bankim J. Gadhari, Nayan S. Kalambate, Pramod K. Karna, Shashi P. Srivastava, Ashwini K. TI Potentiometric stripping analysis of arsenic using a graphene paste electrode modified with a thiacrown ether and gold nanoparticles SO MICROCHIMICA ACTA LA English DT Article DE Arsenic; TTCN; Gold nanoparticles; Graphene paste electrode; Potentiometric stripping analysis; Speciation ID ELECTROCHEMICAL DETECTION; MICROWIRE ELECTRODE; VOLTAMMETRY; PERFORMANCE; ANTIMONY; AS(III); SENSOR AB An electrochemical method is presented for the determination of arsenic at subnanomolar levels. It is based on potentiometric stripping analysis (PSA) using a graphene paste electrode modified with the thiacrown 1,4,7-trithiacyclononane (TTCN) and gold nanoparticles (AuNPs). The electrode surface was characterized by means of cyclic voltammetry, electrochemical impedance spectroscopy, chronocoulometry and scanning electron microscopy. The modified electrode displays a 15-fold enhancement in the PSA signal (dt/dE) compared to a conventional graphene paste electrode. Under optimized conditions, the signal is proportional to the concentration of As(III) in the range from 25 pM to 34 nM (r(2) = 0.9977), and the detection limit (SD/s) is as low as 8 pM. The modified electrode was successfully applied to the determination of total arsenic [i.e., As(III) and As(V)] in pharmaceutical formulations, human hair, sea water, fruits, vegetables, soil, and wine samples. C1 [Sanghavi, Bankim J.] Univ Virginia, Dept Elect & Comp Engn, Charlottesville, VA 22904 USA. [Gadhari, Nayan S.; Kalambate, Pramod K.; Srivastava, Ashwini K.] Univ Mumbai, Dept Chem, Bombay 400098, Maharashtra, India. [Karna, Shashi P.] US Army Res Lab, Weap & Mat Res Directorate, ATTN RDRL WM, Aberdeen Proving Ground, MD 21005 USA. RP Srivastava, AK (reprint author), Univ Mumbai, Dept Chem, Bombay 400098, Maharashtra, India. EM aksrivastava@chem.mu.ac.in FU University Grants Commission, New Delhi, India; US Army International Technology Center, Tokyo, Japan [FA2386-12-1-4086] FX The funding for this work is partly by the University Grants Commission, New Delhi, India and partly by the US Army International Technology Center, Tokyo, Japan through contract number FA2386-12-1-4086. NR 35 TC 11 Z9 11 U1 9 U2 41 PU SPRINGER WIEN PI WIEN PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA SN 0026-3672 EI 1436-5073 J9 MICROCHIM ACTA JI Microchim. Acta PD JUN PY 2015 VL 182 IS 7-8 BP 1473 EP 1481 DI 10.1007/s00604-015-1470-3 PG 9 WC Chemistry, Analytical SC Chemistry GA CI0GF UT WOS:000354414300030 ER PT J AU Kamimori, GH McLellan, TM Tate, CM Voss, DM Niro, P Lieberman, HR AF Kamimori, Gary H. McLellan, Tom M. Tate, Charmaine M. Voss, David M. Niro, Phil Lieberman, Harris R. TI Caffeine improves reaction time, vigilance and logical reasoning during extended periods with restricted opportunities for sleep SO PSYCHOPHARMACOLOGY LA English DT Article DE Sleep loss; Sustained operations; Afternoon sleep; Cognitive function; Marksmanship ID NORMAL HEALTHY-VOLUNTEERS; SLOW-RELEASE CAFFEINE; COGNITIVE PERFORMANCE; RECOVERY SLEEP; NEUROMUSCULAR FUNCTION; CONTINUOUS WAKEFULNESS; SUSTAINED OPERATIONS; MAINTAINS VIGILANCE; ACTIVE WAKEFULNESS; PROPHYLACTIC NAPS AB Various occupational groups are required to maintain optimal physical and cognitive function during overnight periods of wakefulness, often with less than optimal sleep. Strategies are required to help mitigate the impairments in cognitive function to help sustain workplace safety and productivity. To test the effectiveness of repeated 200 mg doses of caffeine on cognitive function and live-fire marksmanship with soldiers during three successive nights of sustained wakefulness followed by 4-h afternoon sleep periods. Twenty Special Forces personnel (28.6 +/- 4.7 years, 177.6 +/- 7.5 cm and 81.2 +/- 8.0 kg) were randomly assigned to receive four 200-mg doses of caffeine (n = 10) or placebo (n = 10) during the late evening and early morning hours during three successive days. An afternoon 4-h sleep period followed. The psychomotor (PVT) and field (FVT) vigilance, logical reasoning (LRT) tests and a vigilance monitor assessed cognitive function throughout the study. Live-fire marksmanship requiring friend-foe discrimination was assessed. Caffeine maintained speed on the PVT (p < 0.02), improved detection of events during FVT (p < 0.001), increased number of correct responses to stimuli as assessed by the vigilance monitor (p < 0.001) and increased response speed during the LRT (p < 0.001) throughout the three overnight testing periods. Live-fire marksmanship was not altered by caffeine. A total daily dose of 800 mg caffeine during successive overnight periods of wakefulness is an effective strategy to maintain cognitive function when optimal sleep periods during the day are not available. C1 [Kamimori, Gary H.] Walter Reed Army Inst Res, Behav Biol Branch, Ctr Psychiat & Neurosci, Silver Spring, MD 20910 USA. [McLellan, Tom M.] DRDC Toronto, Toronto, ON M3M 3B9, Canada. [Tate, Charmaine M.; Voss, David M.] New Zealand Def Force, Auckland, New Zealand. [Niro, Phil; Lieberman, Harris R.] US Army Res Inst Environm Med USARIEM, Mil Nutr Div, Natick, MA 01760 USA. [McLellan, Tom M.] TM McLellan Res Inc, Stouffville, ON L4A 8A7, Canada. RP McLellan, TM (reprint author), TM McLellan Res Inc, 25 Dorman Dr, Stouffville, ON L4A 8A7, Canada. EM DrTom.McLellan@gmail.com FU Oak Ridge Institute for Science and Education FX T.M. McLellan was supported by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and US Army Medical Research and Materiel Command. NR 58 TC 3 Z9 3 U1 2 U2 34 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0033-3158 EI 1432-2072 J9 PSYCHOPHARMACOLOGY JI Psychopharmacology PD JUN PY 2015 VL 232 IS 12 BP 2031 EP 2042 DI 10.1007/s00213-014-3834-5 PG 12 WC Neurosciences; Pharmacology & Pharmacy; Psychiatry SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry GA CI1DG UT WOS:000354481000001 PM 25527035 ER PT J AU Mattis, SA Dawson, CN Kees, CE Farthing, MW AF Mattis, Steven A. Dawson, Clint N. Kees, Christopher E. Farthing, Matthew W. TI An immersed structure approach for fluid-vegetation interaction SO ADVANCES IN WATER RESOURCES LA English DT Article DE Fluid-structure interaction; Environmental modeling; Fluid dynamics ID LARGE-EDDY-SIMULATION; OPEN-CHANNEL FLOW; NONPRISMATIC CANTILEVER BEAMS; LARGE-DEFLECTION ANALYSIS; TURBULENT-FLOW; SUBMERGED VEGETATION; PLANT CANOPY; FLEXIBLE VEGETATION; EMERGENT VEGETATION; CIRCULAR-CYLINDERS AB We present an immersed structure approach for modeling the interaction between surface flows and vegetation. Fluid flow and rigid and flexible vegetative obstacles are coupled through a local drag relation that conserves momentum. In the presented method, separate meshes are used for the fluid domain and vegetative obstacles. Taking techniques from immersed boundary finite element methods, the effects of the fluid on the vegetative structures and vice versa are calculated using integral transforms. Using a simple elastic structure model we incorporate bending and moving vegetative obstacles. We model flexible vegetation as thin, elastic, inextensible cantilever beams. Using the immersed structure approach, a fully coupled fluid-vegetation interaction model is developed assuming dynamic fluid flow and quasi-static bending. This relatively computationally inexpensive model allows for thousands of vegetative obstacles to be included in a simulation without requiring an extremely refined fluid mesh. The method is validated with comparisons to mean velocity profiles and bent vegetation heights from experiments that are reproduced computationally. We test the method on several channel flow setups. We calculate the bulk drag coefficient in these flow scenarios and analyze their trends with changing model parameters including stem population density and flow Reynolds number. Bulk drag models are the primary method of incorporating small-scale drag from individual plants into a value that can be used in larger-scale models. Upscaled bulk drag quantities from this method may be utilized in larger-scale simulations of flow through vegetation regions. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Mattis, Steven A.; Dawson, Clint N.] Univ Texas Austin, Inst Computat Engn & Sci, Austin, TX 78712 USA. [Kees, Christopher E.; Farthing, Matthew W.] US Army Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. RP Mattis, SA (reprint author), Univ Texas Austin, Inst Computat Engn & Sci, 201 E 24th St,Stop C0200, Austin, TX 78712 USA. EM steven@ices.utexas.edu; clint@ices.utexas.edu; christopher.e.kees@usace.army.mil; matthew.w.farthing@usace.army.mil FU U.S. Army Research Office [W911NF-13-1-0082] FX Funding for this work was provided by U.S. Army Research Office Proposal Number 63598-MA, Agreement Number W911NF-13-1-0082. The authors acknowledge the Texas Advanced Computing Center (TACC) at The University of Texas at Austin for providing HPC and visualization resources that have contributed to the research results reported within this paper. URL: http://www.tacc.utexas.edu. NR 72 TC 3 Z9 3 U1 5 U2 14 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0309-1708 EI 1872-9657 J9 ADV WATER RESOUR JI Adv. Water Resour. PD JUN PY 2015 VL 80 BP 1 EP 16 DI 10.1016/j.advwatres.2015.02.014 PG 16 WC Water Resources SC Water Resources GA CH1VU UT WOS:000353811000001 ER PT J AU Suzuki, R Goebert, D Ahmed, I Lu, B AF Suzuki, Rika Goebert, Deborah Ahmed, Iqbal Lu, Brett TI Folk and Biological Perceptions of Dementia Among Asian Ethnic Minorities in Hawaii SO AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY LA English DT Article DE Dementia; perceptions; folk; culture; ethnicity ID ALZHEIMER-DISEASE; FAMILY CAREGIVERS; KNOWLEDGE; BELIEFS; AMERICANS; SEEKING; SAMPLE AB Objective: To study if Asian ethnic groups in Hawaii today maintain folk-based beliefs about dementia, have inadequate biomedical understanding of dementia, and differ among each other regarding perceptions of dementia. Design: The study adapts and expands a 2004 survey of ethnic groups on perceptions of Alzheimer disease demonstrating that ethnic minority groups hold more folk perceptions and less biomedical perceptions of dementia than Caucasians. This study surveys particular ethnic minority family members of elders admitted to four long-term care and inpatient facilities in Hawaii. Seventy-one family members completed surveys, including 23 Chinese, 18 Filipino, and 30 Japanese participants. Elders may or may not have had the diagnosis of dementia, though an estimated half of elders in all four facilities already held the diagnosis of dementia. Results: Findings indicated that Japanese and Chinese respondents in this study held perceptions about dementia that were more consistent with current biomedical understanding compared with their Filipino counterparts (mean differences/percent correct for Japanese: 57%, Chinese: 56% versus Filipino: 38%; F = 6.39, df = 2,55, p = 0.003). Filipino respondents were less likely than Japanese and Chinese respondents to report that persons with dementia can develop physical and mental problems-97% of Japanese participants and 82% of Chinese participants responded correctly compared with 63% of Filipino participants (Fisher's Exact test p = 0.009). With regard to folk beliefs about dementia, variation occurred with no consistent trend among the groups. Conclusion: Low levels of biomedical understanding of dementia were reflected by all three subgroups of Asians living in Hawaii with less prominence of folk beliefs compared with prior studies of ethnic minority perceptions. Education did not predict variability in dementia perceptions among the groups. Lower levels of acculturation, suggested by primary home language other than English, may correlate with a perception of dementia that is less consistent with current biomedical understanding of dementia. Persisting folk beliefs about dementia and the evident lack of biomedical understanding, particularly the belief that dementia is a normal part of aging, emphasizes the need for more culturally tailored strategies in patient education about dementia and the importance of early intervention. C1 [Suzuki, Rika] Kaiser Permanente Hawaii, Honolulu, HI 96814 USA. [Goebert, Deborah] Univ Hawaii, John A Burns Sch Med, Dept Psychiat, Honolulu, HI 96822 USA. [Lu, Brett] Univ Hawaii, John A Burns Sch Med, Dept Geriatr Psychiat, Honolulu, HI 96822 USA. [Ahmed, Iqbal] Tripler Army Med Ctr, Dept Psychiat, Honolulu, HI 96859 USA. RP Suzuki, R (reprint author), Kaiser Permanente Hawaii, 1441 Kapiolani Blvd,Ste 1600, Honolulu, HI 96814 USA. EM ikasu@gmail.com NR 16 TC 1 Z9 1 U1 2 U2 5 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1064-7481 EI 1545-7214 J9 AM J GERIAT PSYCHIAT JI Am. J. Geriatr. Psychiatr. PD JUN PY 2015 VL 23 IS 6 BP 589 EP 595 DI 10.1016/j.jagp.2014.03.012 PG 7 WC Geriatrics & Gerontology; Gerontology; Psychiatry SC Geriatrics & Gerontology; Psychiatry GA CH9EF UT WOS:000354338100006 PM 24801608 ER PT J AU White, JO Engin, D Akbulut, M Rakuljic, G Satyan, N Vasilyev, A Yariv, A AF White, Jeffrey O. Engin, Doruk Akbulut, Mehmetcan Rakuljic, George Satyan, Naresh Vasilyev, Arseny Yariv, Amnon TI Chirped Laser Seeding for SBS Suppression in a 100-W Pulsed Erbium Fiber Amplifier SO IEEE JOURNAL OF QUANTUM ELECTRONICS LA English DT Article DE Fiber amplifiers; stimulated Brillouin scattering; chirp modulation; fiber nonlinear optics; erbium-doped fiber amplifiers; numerical simulation; finite difference methods ID STIMULATED BRILLOUIN-SCATTERING; OPTICAL-FIBERS; HIGH-POWER; PHASE; LOCKING AB A pulsed Er/Yb fiber amplifier is seeded with a frequency-chirped diode laser for the purpose of suppressing stimulated Brillouin scattering (SBS), as an alternative to the conventional broadband seed. SBS in the final stage of the amplifier limits the output power. A chirp of 5 . 10(15) Hz/s is seen to increase the SBS threshold by nine times, compared with the case with no chirp. The final stage of the amplifier is modeled with a system of equations that are solved for the laser field, Stokes field, acoustic field, pump power, amplified spontaneous emission power, Yb inversion, and Er inversion, as a function of z and t. The experimental and theoretical results are in good agreement. The SBS threshold scales linearly with chirp, when the effective seed linewidth (the product of chirp and fiber transit time) is much greater than the Brillouin linewidth. C1 [White, Jeffrey O.] US Army Res Lab, Adelphi, MD 20783 USA. [Engin, Doruk; Akbulut, Mehmetcan] Fibertek Inc, Herndon, VA 20171 USA. [Rakuljic, George; Satyan, Naresh] Telaris Inc, Santa Monica, CA 90403 USA. [Vasilyev, Arseny; Yariv, Amnon] CALTECH, Dept Appl Phys & Mat Sci, Pasadena, CA 91125 USA. [Yariv, Amnon] CALTECH, Dept Elect & Comp Engn, Pasadena, CA 91125 USA. RP White, JO (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM jeffrey.owen.white@us.army.mil; dengin@fibertek.com; akbulutm@gmail.com; rakuljic@telarisinc.com; satyan@telarisinc.com; arseny.vasilyev@jdsu.com; ayariv@caltech.edu FU U.S. Army Research Office [W911NF-11-2-0081]; High Energy Laser Joint Technology Office [11-SA-0405] FX This work was supported in part by the U.S. Army Research Office under Grant W911NF-11-2-0081 and in part by the High Energy Laser Joint Technology Office under Contract 11-SA-0405. NR 31 TC 1 Z9 1 U1 3 U2 28 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9197 EI 1558-1713 J9 IEEE J QUANTUM ELECT JI IEEE J. Quantum Electron. PD JUN PY 2015 VL 51 IS 6 AR 6800110 DI 10.1109/JQE.2015.2425963 PG 10 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA CI0UA UT WOS:000354452500001 ER PT J AU Serban, R Melanz, D Li, A Stanciulescu, I Jayakumar, P Negrut, D AF Serban, Radu Melanz, Daniel Li, Ang Stanciulescu, Ilinca Jayakumar, Paramsothy Negrut, Dan TI A GPU-based preconditioned Newton-Krylov solver for flexible multibody dynamics SO INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN ENGINEERING LA English DT Article DE inexact Newton; sparse linear system; preconditioning; implicit integration; SPIKE; ANCF; GPU computing ID NODAL COORDINATE FORMULATION; PERMUTING LARGE ENTRIES; SPIKE ALGORITHM; SPARSE MATRICES; SYSTEM SOLVER; EQUATIONS; BODY AB This paper describes an approach to numerically approximate the time evolution of multibody systems with flexible (compliant) components. Its salient attribute is that at each time step, both the formulation of the system equations of motion and their numerical solution are carried out using parallel computing on graphics processing unit cards. The equations of motion are obtained using the absolute nodal coordinate formulation, yet any other multibody dynamics formalism would fit equally well the overall solution strategy outlined herein. The implicit numerical integration method adopted relies on a Newton-Krylov methodology and a parallel direct sparse solver to precondition the underlying linear system. The proposed approach, implemented in a software infrastructure available under an open-source BSD-3 license, leads to improvements in overall simulation times of up to one order of magnitude when compared with matrix-free parallel solution approaches that do not use preconditioning. Copyright (C) 2015 John Wiley & Sons, Ltd. C1 [Serban, Radu; Melanz, Daniel; Negrut, Dan] Univ Wisconsin, Mech Engn, Madison, WI 53706 USA. [Li, Ang; Negrut, Dan] Univ Wisconsin, Elect & Comp Engn, Madison, WI 53706 USA. [Stanciulescu, Ilinca] Rice Univ, Civil & Environm Engn, Houston, TX 77005 USA. [Jayakumar, Paramsothy] US Army TARDEC, Warren, MI 48397 USA. RP Serban, R (reprint author), 2047 ME,1513 Univ Ave, Madison, WI 53706 USA. EM serban@engr.wisc.edu OI Stanciulescu, Ilinca/0000-0003-4515-0363 FU US Army TARDEC ARO [W911NF-11-D-0001-0107]; National Science Foundation [SI2-SSE-1147337]; Army Research Office [W911NF-11-1-0327] FX Financial support has been provided in part by a US Army TARDEC ARO grant under Contract No. W911NF-11-D-0001-0107, National Science Foundation grant SI2-SSE-1147337, and the Army Research Office instrumentation grant W911NF-11-1-0327. NR 46 TC 1 Z9 1 U1 1 U2 8 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0029-5981 EI 1097-0207 J9 INT J NUMER METH ENG JI Int. J. Numer. Methods Eng. PD JUN 1 PY 2015 VL 102 IS 9 BP 1585 EP 1604 DI 10.1002/nme.4876 PG 20 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications SC Engineering; Mathematics GA CH3VJ UT WOS:000353958300003 ER PT J AU Dehghani, M Khooshabeh, P Nazarian, A Gratch, J AF Dehghani, Morteza Khooshabeh, Peter Nazarian, Angela Gratch, Jonathan TI The Subtlety of Sound: Accent as a Marker for Culture SO JOURNAL OF LANGUAGE AND SOCIAL PSYCHOLOGY LA English DT Article DE accent; culture; frame-switching; biculturalism ID ETHNIC AFFIRMATION; INDIVIDUALISM; COLLECTIVISM; LANGUAGE; SELF; BILINGUALS; COGNITION AB Aspects of language, such as accent, play a crucial role in the formation and categorization of one's cultural identity. Recent work on accent emphasizes the role of accent in person perception and social categorization, demonstrating that accent also serves as a meaningful indicator of an ethnic category. In this article, we investigate whether the accent of an interaction partner, as a marker for culture, can induce cultural frame-shifts in biculturals. We report the results of three experiments, performed among bicultural and monocultural individuals, in which we test the above hypothesis. Our results demonstrate that accent alone can affect people's cognition. C1 [Dehghani, Morteza; Gratch, Jonathan] Univ So Calif, Brain & Creat Inst BCI, Psychol, Comp Sci, Los Angeles, CA 90089 USA. [Khooshabeh, Peter] Univ So Calif, Los Angeles, CA 90089 USA. [Nazarian, Angela] Univ So Calif, Inst Creat Technol, Los Angeles, CA 90089 USA. [Gratch, Jonathan] Univ So Calif, Inst Creat Technol, Virtual Human Res, Los Angeles, CA 90089 USA. [Khooshabeh, Peter] Army Res Lab, Human Res & Engn Directorate, Adelphi, MD USA. RP Dehghani, M (reprint author), Univ So Calif, Dept Psychol, Los Angeles, CA 90089 USA. EM mdehghan@usc.edu OI Dehghani, Morteza/0000-0002-9478-4365 FU Air Force Young Investigator Research Program; Army Research Lab; National Science Foundation Information Intelligent System [0916858] FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was supported by Air Force Young Investigator Research Program to MD, a postdoctoral fellowship to PK from the Army Research Lab, and National Science Foundation Information Intelligent System-0916858 to JG. NR 24 TC 2 Z9 2 U1 4 U2 12 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0261-927X EI 1552-6526 J9 J LANG SOC PSYCHOL JI J. Lang. Soc. Psychol. PD JUN PY 2015 VL 34 IS 3 BP 231 EP 250 DI 10.1177/0261927X14551095 PG 20 WC Communication; Linguistics; Psychology, Social SC Communication; Linguistics; Psychology GA CI0FA UT WOS:000354410700001 ER PT J AU Ungerman, MD Walker, AM AF Ungerman, Meyer D. Walker, Amber M. TI Characterization of Flexinol (R) as a Lightweight Biomechanical Actuator SO JOURNAL OF MEDICAL DEVICES-TRANSACTIONS OF THE ASME LA English DT Article; Proceedings Paper CT Design of Medical Devices DMD Conference CY APR 13-16, 2015 CL McNamara Alumni Ctr, Minneapolis, MN HO McNamara Alumni Ctr C1 [Ungerman, Meyer D.; Walker, Amber M.] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. NR 5 TC 0 Z9 0 U1 1 U2 2 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 1932-6181 EI 1932-619X J9 J MED DEVICES JI J. Med. Devices PD JUN PY 2015 VL 9 IS 2 AR 020940 DI 10.1115/1.4030147 PG 2 WC Engineering, Biomedical SC Engineering GA CH4WY UT WOS:000354035200041 ER PT J AU Rizzo, JA Sherman, WE Arciero, CA AF Rizzo, Julie A. Sherman, William E. Arciero, Cletus A. TI Racial Disparity in Survival From Early Breast Cancer in the Department of Defense Healthcare System SO JOURNAL OF SURGICAL ONCOLOGY LA English DT Article DE breast cancer; survival; Department of Defense ID AFRICAN-AMERICAN; SOCIOECONOMIC-STATUS; SOUTHWEST-ONCOLOGY; WHITE WOMEN; ASIAN WOMEN; CARCINOMA; RACE; BENEFICIARIES; MAMMOGRAPHY; ETHNICITY AB BackgroundRacial disparity is often identified as a factor in survival from breast cancer in the United States. Current data regarding survival in patients treated in the Department of Defense Military Healthcare System is lacking. MethodsThe Department of Defense Automated Central Tumor Registry (ACTUR) was queried for all women diagnosed with Stage I or II breast cancer from January 1, 1996 through December 31, 2008. Statistical analyses evaluated demographics, surgical treatment, tumor stage, and survival rates. ResultsThere were 8,890 patients meeting inclusion criteria. Patients who were younger, Asian American (versus white or black), lower T and/or N stage had significantly improved survival rates. Interestingly, white and black patients demonstrated similar survival in this study. Patients with a longer period of time between diagnosis and treatment had no decrement in survival. As would be expected, patients with a longer recurrence free period enjoyed longer survival. ConclusionsSurvival from early stage breast cancer is equivalent between white and black patients in the Department of Defense Healthcare System. This finding is contrary to reports from our civilian counterparts and may be indicative of improved access to care and overall improved cancer surveillance. J. Surg. Oncol. 2015 111:819-823. (c) 2014 Wiley Periodicals, Inc. C1 [Rizzo, Julie A.] US Inst Surg Res, Ft Sam Houston, TX USA. [Sherman, William E.; Arciero, Cletus A.] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA USA. RP Rizzo, JA (reprint author), US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. EM julie.a.rizzo.mil@mail.mil NR 29 TC 2 Z9 2 U1 2 U2 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0022-4790 EI 1096-9098 J9 J SURG ONCOL JI J. Surg. Oncol. PD JUN 1 PY 2015 VL 111 IS 7 BP 819 EP 823 DI 10.1002/jso.23884 PG 5 WC Oncology; Surgery SC Oncology; Surgery GA CH4IE UT WOS:000353996400005 PM 25711959 ER PT J AU Thomas, D Anderson, D Hulten, E McRae, F Ellis, S Malik, JA Villines, TC Slim, AM AF Thomas, Dustin Anderson, David Hulten, Edward McRae, Fiora Ellis, Shane Malik, Jamil A. Villines, Todd C. Slim, Ahmad M. TI Open versus endovascular repair of abdominal aortic aneurysm: Incidence of cardiovascular events in 632 patients in a department of defense cohort over 6-year follow-up SO VASCULAR LA English DT Article DE Endovascular; open; abdominal aortic aneurysm; cardiovascular outcomes; myocardial infarction ID ATRIAL-FIBRILLATION; MYOCARDIAL DAMAGE; SURGERY; TRIAL AB Background Abdominal aortic aneurysm (AAA) is common with unacceptably high rates of mortality and morbidity with unknown rates of complications after repair in the Department of Defense (DoD). Methods All patients treated at a DOD or VA clinic or medical facility with a diagnosis of AAA identified by ICD-9 code search were identified by Patient Administration Systems and Biostatistics Activity (PASBA) using the Standard Inpatient Data Record (SIDR) and Composite Ambulatory Patient Encounter Record (CAPER) from January 2006 till December 2011. The primary outcome was death, myocardial infarction (MI), stroke, and cardiac arrhythmia between subjects who underwent endovascular aortic repair (EVAR) or open aortic repair (OAR). Results A total of 8314 patients were screened to identify 632 patients who underwent surgical repair of non-ruptured AAA. EVAR was performed in 497 patients (78.6%) and OAR in 135 patients (21.4%). Mortality at 30 days was less common in EVAR patients (1.6% vs. 6.7%, p=0.004), but was not sustained (16.9% vs. 17.8%, p=0.797). Mean survival free from mortality was not different between the two groups (EVAR vs. OAR: 6.140.13 years vs. 6.11 +/- 0.22 years, p=0.378). The composite endpoint of MI, stroke, arrhythmia, or death was not different between groups at 30 days (EVAR vs. OAR: 12.9% vs. 14.1%, p=0.774) or in long-term follow-up population (EVAR vs. OAR: 40.6% vs. 31.9%, p=0.073) though there was a trend toward higher event rates in the EVAR. The composite endpoint of MI, stroke, and arrhythmia occurred in 198 patients (31%). Conclusion EVAR was associated with lower 30-day mortality rates; however, this benefit was not sustained in longer-term follow-up. There is no difference in the rates of stroke, myocardial infarction, or cardiac arrhythmia at 30 days or in long-term follow-up. C1 [Thomas, Dustin; Anderson, David; McRae, Fiora; Ellis, Shane; Malik, Jamil A.; Slim, Ahmad M.] Brooke Army Med Ctr, Serv Cardiol, San Antonio, TX USA. [Hulten, Edward; Villines, Todd C.] Walter Reed Natl Mil Med Ctr, Serv Cardiol, Bethesda, MD USA. RP Slim, AM (reprint author), Brooke Army Med Ctr, 3551 Roger Brooke Dr, San Antonio, TX 78234 USA. EM ahmad.m.slim.mil@mail.mil NR 11 TC 2 Z9 2 U1 0 U2 2 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1708-5381 EI 1708-539X J9 VASCULAR JI Vascular PD JUN PY 2015 VL 23 IS 3 BP 234 EP 239 DI 10.1177/1708538114546207 PG 6 WC Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA CH8AC UT WOS:000354257000002 PM 25134851 ER PT J AU Scenna, R Gupta, AK AF Scenna, Richard Gupta, Ashwani K. TI Partial oxidation of JP8 in a distributed reactor SO FUEL PROCESSING TECHNOLOGY LA English DT Article DE Fuel reforming; Non-catalytic partial oxidation; Volume distributed thermal oxidation; Syngas production from JP8; Reformation efficiency ID SOOT FORMATION; COMBUSTION AB Volume distributed reaction technique was applied to examine the partial oxidation behavior of JP8 with the goal to improve reformate quality. The reactor design was based on previously developed volume distributed combustion, but modified to foster unique reforming conditions. The reactor demonstrated almost colorless reaction zone even at a high equivalence ratio of Phi = 3.0 (that is normally a soot formation regime), with no visible soot found on the walls of the reactor. A stable reaction zone was demonstrated at low temperatures of 764-863 degrees C. Reformate concentration consisted of 8.68-9.92% hydrogen and 18.12-18.58% carbon monoxide, which is significantly higher than that available in the literature on partial oxidation at temperatures of 700-800 degrees C (only 4.0-7.5% hydrogen and 5.7-17% carbon monoxide). Acetylene concentrations under distributed reaction regime were 20-23% lower than that in conventional flames. The results show that volume distributed reactions offer significant advantages to produce higher concentrations of hydrogen and carbon monoxide and very low amounts of acetylene that is a well-known precursor to soot formation. (C) 2015 Elsevier B.V. All rights reserved. C1 [Scenna, Richard; Gupta, Ashwani K.] Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA. [Scenna, Richard] US Army, CERDEC, CPI, Res Dev & Engn Command, Reno, NV USA. RP Gupta, AK (reprint author), Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA. EM akgupta@umd.edu FU CERDEC's independent laboratory innovative research (ILIR) program FX This research was supported by CERDEC's independent laboratory innovative research (ILIR) program and is gratefully acknowledged. NR 20 TC 4 Z9 4 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-3820 EI 1873-7188 J9 FUEL PROCESS TECHNOL JI Fuel Process. Technol. PD JUN PY 2015 VL 134 BP 205 EP 213 DI 10.1016/j.fuproc.2015.01.036 PG 9 WC Chemistry, Applied; Energy & Fuels; Engineering, Chemical SC Chemistry; Energy & Fuels; Engineering GA CH0UZ UT WOS:000353739200025 ER PT J AU Wilson, KL Allen, MS Ahrens, RNM Netherland, MD AF Wilson, Kyle L. Allen, Micheal S. Ahrens, Robert N. M. Netherland, Michael D. TI Nonlinear and density-dependent fish habitat selection across physiochemical gradients in an invasive macrophyte habitat SO ENVIRONMENTAL BIOLOGY OF FISHES LA English DT Article DE Lepomis macrochirus; Hydrilla verticillata; Aquatic plant management; Fish-macrophyte relationships; Freshwater fisheries; Underwater video ID LARGEMOUTH BASS; REGRESSION-MODELS; AQUATIC PLANTS; LITTORAL-ZONE; HYPOXIA; HYDRILLA; LAKE; ABUNDANCE; PREDATION; OXYGEN AB Invasive macrophytes drive substantial changes to freshwater fish habitats. Such changes can influence how fish select for habitats, but fish-habitat relationships in many invasive macrophytes are often poorly understood at micro-scales. Fish habitat use is influenced by dissolved oxygen (DO) and habitat complexity, but this response can be nonlinear and dependent upon fish density. This study tested whether microhabitat use of sunfish (Lepomis spp.) in invasive macrophyte beds was density-dependent. Fish were sampled with underwater video point counts in six 0.405 ha experimental ponds with surface-matted hydrilla Hydrilla verticillata and stocked with varying densities of sunfishes. Regression models were used to evaluate the key drivers for fish habitat selection across DO, complexity and fish densities. Both fish occurrence and fish counts were positively influenced by DO and negatively influenced by habitat complexity, but the fish counts-DO relationship was dome-shaped and both fish occurrence and counts depended upon fish densities. For example, at high fish densities, fish used low and high DO and high macrophyte complexity; at low fish densities, fish avoided such areas. Fish counts peaked at intermediate DO and low macrophyte complexity. Density-dependent fish habitat selection appeared to mitigate detrimental effects of invasive macrophytes on fish habitats, indicating that fish can and do use 'inhospitable' habitats with potential positive population growth. Understanding density-dependent habitat selection is needed when evaluating the quality of habitats, as apparently inhospitable habitats can be utilized when fish density is high. C1 [Wilson, Kyle L.; Allen, Micheal S.; Ahrens, Robert N. M.] Univ Florida, Program Fisheries & Aquat Sci, Sch Forest Resources & Conservat, Gainesville, FL 32653 USA. [Netherland, Michael D.] US Army, Engineer Res & Dev Ctr, Gainesville, FL 32653 USA. RP Wilson, KL (reprint author), Univ Calgary, Dept Biol Sci, 2500 Univ Dr NW, Calgary, AB T2N 1N4, Canada. EM wilsok@ucalgary.ca OI Wilson, Kyle/0000-0002-0870-0509 FU Florida Fish and Wildlife Conservation Commission Invasive Plant Management Section FX The authors thank the Florida Fish and Wildlife Conservation Commission Invasive Plant Management Section for financial support and the U.S. Geological Survey Southeastern Ecological Science Center for access to the experimental ponds. This research was permitted under the Institutional Animal Care and Use Committee permit #USGS/SESC 2011-09 under Category I (no direct impact on animals). The authors thank the University of Florida's Dan Gwinn for advice on analyses and Jeremy Slade for help on project development as well as Erin Bradshaw, Nicholas Cole, Zack Slagle, Simone Nageon de Lestang, and Antonio Malouf for field collections and video analysis. NR 57 TC 1 Z9 1 U1 3 U2 34 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0378-1909 EI 1573-5133 J9 ENVIRON BIOL FISH JI Environ. Biol. Fishes PD JUN PY 2015 VL 98 IS 6 BP 1525 EP 1539 DI 10.1007/s10641-015-0379-3 PG 15 WC Ecology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA CG3ZK UT WOS:000353218800005 ER PT J AU Sakkhachornphop, S Kijak, GH Beyrer, C Razak, MH Sanders-Buell, E Jittiwutikarn, J Suriyanon, V Robb, ML Kim, JH Celentano, DD McCutchan, FE Tovanabutra, S AF Sakkhachornphop, Supachai Kijak, Gustavo H. Beyrer, Chris Razak, Myat Htoo Sanders-Buell, Eric Jittiwutikarn, Jaroon Suriyanon, Vinai Robb, Merlin L. Kim, Jerome H. Celentano, David D. McCutchan, Francine E. Tovanabutra, Sodsai TI An effective tool for identifying HIV-1 subtypes B, C, CRF01_AE, their recombinant forms, and dual infections in Southeast Asia by the multi-region subtype specific PCR (MSSP) assay SO JOURNAL OF VIROLOGICAL METHODS LA English DT Article DE HIV-1; Subtyping; MSSP assay; Subtype specific PCR; Southeast Asia ID IMMUNODEFICIENCY-VIRUS TYPE-1; HETERODUPLEX MOBILITY ASSAY; POLYMERASE-CHAIN-REACTION; THAI DRUG-USERS; MOLECULAR EPIDEMIOLOGY; DISEASE PROGRESSION; NORTHERN THAILAND; GENOTYPING ASSAY; VACCINE EFFICACY; HIGH-THROUGHPUT AB The RV144 Thai vaccine trial has been the only vaccine study to show efficacy in preventing HIV infection. Ongoing molecular surveillance of HIV-1 in Southeast Asia is vital for vaccine development and evaluation. In this study a novel tool, the multi-region subtype specific PCR (MSSP) assay, that was able to identify subtypes B, C, CRF01_AE for Thailand, other Southeast Asian countries, India and China is described. The MSSP assay is based on a nested PCR strategy and amplifies eight short regions distributed along the HIV-1 genome using subtype-specific primers. A panel of 41 clinical DNA samples obtained primarily from opiate users in northern Thailand was used to test the assay performance. The MSSP assay provided 73-100% sensitivity and 100% specificity for the three subtypes in each genome region. The assay was then field-tested on 337 sera from HIV infected northern Thai drug users collected between 1999 and 2002. Subtype distribution was CRF01_AE 77.4% (n=261), subtype B 33% (n =11), CRFOLAE/B recombinant 12.2% (n= 41), CRF01_AE/C recombinant 0.6% (n = 2), and non-typeable 6.5% (n =22). The MSSP assay is a simple, cost-effective, and accurate genotyping tool for laboratory settings with limited resources and is sensitive enough to capture the recombinant genomes and dual infections. (C) 2015 Elsevier B.V. All rights reserved. C1 [Sakkhachornphop, Supachai; Suriyanon, Vinai] Chiang Mai Univ, Res Inst Hlth Sci, Chiang Mai 50200, Thailand. [Kijak, Gustavo H.; Sanders-Buell, Eric; Robb, Merlin L.; McCutchan, Francine E.; Tovanabutra, Sodsai] US Mil HIV Res Program MHRP, Henry M Jackson Fdn Adv Mil Med, Silver Spring, MD 20910 USA. [Beyrer, Chris; Celentano, David D.] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA. [Razak, Myat Htoo] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. [Jittiwutikarn, Jaroon] Northern Drug Treatment Ctr, Chiang Mai 50200, Thailand. [Kim, Jerome H.] US Mil HIV Res Program MHRP, Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Tovanabutra, S (reprint author), Walter Reed Army Inst Res, MHRP & Henry M Jackson Fdn Adv Mil Med HJF, 503 Robert Grant Ave,Room 2N25, Silver Spring, MD 20910 USA. EM stovanabutra@hivresearch.org FU Fogarty AIDS International for Research and Training Program; Johns Hopkins Bloomberg School of Public Health [D43TW000010-25]; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-11-2-0174]; U.S. Department of Defense (DOD); National Research University Project under Thailand's Office of the Higher Education Commission FX We are very grateful to the subjects for their participation in this study. The authors thank staff members at the Henry M. Jackson Foundation for technical advice, the research staffs at Northern Drug Treatment Center and RIHES for Cohort building and specimen collections. We extend our gratitude to Dr. Thira Sirisanthana, Dr. Namtip Srirak, Mr. Kittipong Rungruengthanakit, Mr. Rassamee Keawvichit, Mrs. Kanlaya Wongworapat and Mr. Peter Lange for their advice and supports on conducting the study. We are indebted to Ms. Meera Bose and Mr. Peter Phuc Pham for HIV-1 sequence analysis. This study was supported by the Fogarty AIDS International for Research and Training Program, Johns Hopkins Bloomberg School of Public Health, grants number D43TW000010-25 and a cooperative agreement (W81XWH-11-2-0174) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense (DOD). We wish to thank the National Research University Project under Thailand's Office of the Higher Education Commission for partial financial support. NR 49 TC 0 Z9 0 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-0934 EI 1879-0984 J9 J VIROL METHODS JI J. Virol. Methods PD JUN 1 PY 2015 VL 217 BP 70 EP 78 DI 10.1016/j.jviromet.2015.02.015 PG 9 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Virology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Virology GA CG2FV UT WOS:000353091200012 PM 25725414 ER PT J AU Sivasuthan, S Karthik, VU Rahunanthan, A Jayakumar, P Thyagarajan, RS Udpa, L Hoole, SRH AF Sivasuthan, S. Karthik, V. U. Rahunanthan, A. Jayakumar, P. Thyagarajan, R. S. Udpa, Lalita Hoole, S. R. H. TI Addressing Memory and Speed Problems in Nondestructive Defect Characterization: Element-by-Element Processing on a GPU SO JOURNAL OF NONDESTRUCTIVE EVALUATION LA English DT Article DE CUDA; GPU; FEM; Parallelization; NDE ID OPTIMAL-DESIGN; PARALLEL; UNITS; FEM; ALGORITHM; FIELDS AB In nondestructive defect characterization, the genetic algorithm matches measurements to computations through finite element optimization of a parametrically described defect. This poses a huge computational load. A published element-by-element (EbE) conjugate gradients (CG) method for the graphics processing unit (GPU) parallelizes thematrix solution process. However, in finite element optimization for non-destructive evaluation (NDE), thousands of simultaneous finite element matrix solutions on parallel genetic algorithm threads on a GPU are required. This challenges the memory capabilities of aGPUand results in long waiting times making the NDE technique impracticable. To address these twin time and memory problems, we revive an old EbE processing by Gauss iterations. It yields speedups of 80+ which grow indefinitely with matrix size to values much bigger than those reported for EbE CG. For the latter the reported figures were less than 4 for the practicable matrix size of 91,333, and 96 for a size of over 1 million and falling thereafter. Our EbE implementation of CG gives a speedup of 147 for first order triangular meshes. No memory issues are faced. C1 [Sivasuthan, S.; Karthik, V. U.; Udpa, Lalita; Hoole, S. R. H.] Michigan State Univ, Dept Elect & Comp Engn, E Lansing, MI 48824 USA. [Rahunanthan, A.] Edinboro Univ, Dept Math & Comp Sci, Edinboro, PA 16444 USA. [Jayakumar, P.; Thyagarajan, R. S.] US Army Tank Automot Res Dev & Engn Ctr, Warren, MI 48397 USA. RP Hoole, SRH (reprint author), Michigan State Univ, Dept Elect & Comp Engn, E Lansing, MI 48824 USA. EM srhhoole@gmail.com FU US Army's TARDEC [W911NF-11-D-0001] FX This work was funded in part by the US Army's TARDEC under Contract Number W911NF-11-D-0001. Having been performed for the US Government under contract, no copyright restrictions apply and may be distributed in the US without restriction (Approval reference 24797). NR 26 TC 0 Z9 0 U1 1 U2 11 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0195-9298 EI 1573-4862 J9 J NONDESTRUCT EVAL JI J. Nondestruct. Eval. PD JUN PY 2015 VL 34 IS 2 AR 9 DI 10.1007/s10921-015-0282-z PG 7 WC Materials Science, Characterization & Testing SC Materials Science GA CF7AM UT WOS:000352708400004 ER PT J AU Tanabe, K Zollner, G Vaughan, JA Sattabongkot, J Khuntirat, B Honma, H Mita, T Tsuboi, T Coleman, R AF Tanabe, Kazuyuki Zollner, Gabriela Vaughan, Jefferson A. Sattabongkot, Jetsumon Khuntirat, Benjawan Honma, Hajime Mita, Toshihiro Tsuboi, Takafumi Coleman, Russell TI Plasmodium falciparum: Genetic diversity and complexity of infections in an isolated village in western Thailand SO PARASITOLOGY INTERNATIONAL LA English DT Article DE Malaria; Plasmodium falciparum; Genetic diversity; msp1; csp; ama1 ID SURFACE PROTEIN-1 GENE; PAPUA-NEW-GUINEA; ALLELIC DIVERSITY; MALARIA PARASITE; CIRCUMSPOROZOITE PROTEIN; POINT MUTATIONS; CHLOROQUINE USE; POPULATION; RECOMBINATION; RESISTANCE AB Genetic diversity of Plasmodium falciparum is intimately associated with morbidity, mortality and malaria control strategies. It is therefore imperative to study genetic makeup and population structure of this parasite in endemic areas. In Kong Mong Tha, an isolated village in western Thailand, the majority of P. falciparum infections are asymptomatic. In this study we investigated complexity of infections and single nucleotide polymorphisms (SNPs) in the P. falciparum population of Kong Mong Tha, and compared results with those previously obtained from Mae Sod, in northwestern Thailand, where the majority of infections were symptomatic. Using PCR-based determination of the 5' merozoite surface protein 1 gene (msp1) recombinant types, we found that 39% of 59 P. falciparum isolates from Kong Mong Tha had multiple 5' recombinant types with a mean number of 1.54. These values were much lower than those obtained from Mae Sod: 96% for multiple infections and with a mean number of 3.61. Analysis of full-length sequences of two housekeeping genes, the P-type Ca2+-transporting ATPase gene (n = 33) plus adenylosuccinate lyase gene (n = 33), and three vaccine candidate antigen genes, msp1 (n = 26), the circumsporozoite protein gene, csp (n = 30) and the apical membrane antigen 1 gene, ama1 (n = 32), revealed that in all of these genes within-population SNP diversity was at similar levels between Kong Mong Tha and Mae Sod, suggesting that the extent of MOI and clinical manifestations of malaria are not strongly associated with genetic diversity. Additionally, we did not detect significant genetic differentiation between the two parasite populations, as estimated by the Wright's fixation index of inter-population variance in allele frequencies, suggesting that gene flow prevented the formation of population structuring. Thus, this study highlights unique features of P. falciparum populations in Thailand. The implications of these finding are discussed. (C) 2013 Elsevier Ireland Ltd. All rights reserved. C1 [Tanabe, Kazuyuki] Osaka Univ, Microbial Dis Res Inst, Lab Malariol, Suita, Osaka 5650871, Japan. [Tanabe, Kazuyuki] Osaka Univ, Microbial Dis Res Inst, Dept Mol Protozool, Suita, Osaka 5650871, Japan. [Zollner, Gabriela; Sattabongkot, Jetsumon; Khuntirat, Benjawan; Coleman, Russell] Armed Forces Res Inst Med Sci, US Army Med Component, Dept Entomol, Bangkok 10400, Thailand. [Vaughan, Jefferson A.] Univ N Dakota, Dept Biol, Grand Forks, ND 58202 USA. [Honma, Hajime; Mita, Toshihiro] Tokyo Womens Med Univ, Dept Int Affairs & Trop Med, Tokyo, Japan. [Mita, Toshihiro] Juntendo Univ, Sch Med, Dept Mol & Cellular Parasitol, Tokyo 1138421, Japan. [Tsuboi, Takafumi] Ehime Univ, Proteo Sci Ctr, Div Malaria Res, Matsuyama, Ehime 7908577, Japan. RP Tanabe, K (reprint author), Osaka Univ, Microbial Dis Res Inst, Dept Mol Protozool, 3-1 Yamada Oka, Suita, Osaka 5650871, Japan. EM kztanabe@biken.osaka-u.ac.jp; tsuboi@ccr.ehime-u.ac.jp; russell.coleman@us.army.mil FU Ministry of Education, Culture, Sports, Science and Technology of Japan [18073013, 23117008, 23659211, 23590498]; Foundation of Strategic Research Projects in Private Universities [S0991013]; NIH [AI48813] FX We thank Dr. Naoko Sakihama for technical assistance. This work was supported by the Grant-in-Aids for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan (18073013, 23117008, 23659211 and 23590498) and Foundation of Strategic Research Projects in Private Universities (S0991013). The collection of Plasmodium isolates in Kong Mong Tha was provided by NIH grant AI48813 to J.A. Vaughan and by the Military Infectious Diseases Research Program of the U.S. Army Medical Research and Materiel Command, Fort Detrick, MD. This work was performed while G. Zollner was a NRC Postdoctoral Research Associate at AFRIMS. NR 50 TC 1 Z9 1 U1 0 U2 9 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 1383-5769 J9 PARASITOL INT JI Parasitol. Int. PD JUN PY 2015 VL 64 IS 3 BP 260 EP 266 DI 10.1016/j.parint.2013.09.011 PG 7 WC Parasitology SC Parasitology GA CE4JM UT WOS:000351796900013 PM 24060540 ER PT J AU Rong, CC Barnes, PN Levin, GA Miller, JD Santosusso, DJ Fitzpatrick, BK AF Rong, Charles C. Barnes, Paul N. Levin, George A. Miller, Jason D. Santosusso, Daniel J. Fitzpatrick, Brian K. TI Investigation of the Relaxation of Persistent Current in Superconducting Closed Loops Made Out of YBCO Coated Conductors SO IEEE TRANSACTIONS ON APPLIED SUPERCONDUCTIVITY LA English DT Article DE Coated conductor; current sweep reversal method; MAGLEV; MRI; persistent current; relaxation rate; SMES; 2GHTS ID MAGNETIC-FIELD; MODE MAGNET; FLUX-CREEP AB Coated conductors allow the fabrication of closed superconducting loops of arbitrary size. Various mechanisms can play a role in the decay of a persistent current in one such loop and in an assembly of multiple loops magnetically coupled with each other. We report recent experimental results on the relaxation rate of the persistent current in an assembly of closed superconducting loops made out of the currently manufactured coated conductors. One of the main goals of this study is to find the effective ways to control the relaxation rate so as to make it small enough to enable such high temperature persistent magnets to be considered as potential alternatives for energy storage, MRI magnets, and magnetic levitation applications. Here we report the effect of appropriately modified current sweep reversal method on the relaxation rate. C1 [Rong, Charles C.; Barnes, Paul N.] Army Res Lab, Adelphi, MD 20783 USA. [Levin, George A.] Florida Inst Technol, Dept Phys & Space Sci, Melbourne, FL 32901 USA. [Miller, Jason D.; Santosusso, Daniel J.; Fitzpatrick, Brian K.] Naval Surface Warfare Ctr, Carderock Div, Philadelphia, PA 19112 USA. RP Rong, CC (reprint author), Army Res Lab, Adelphi, MD 20783 USA. EM charles.c.rong.civ@mail.mil FU Army Research Laboratory FX This project was supported by the Army Research Laboratory. NR 22 TC 0 Z9 0 U1 0 U2 15 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1051-8223 EI 1558-2515 J9 IEEE T APPL SUPERCON JI IEEE Trans. Appl. Supercond. PD JUN PY 2015 VL 25 IS 3 AR 8200805 DI 10.1109/TASC.2014.2376173 PG 5 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA CC4VH UT WOS:000350351900028 ER PT J AU Wu, J Shi, J Baca, J Emergo, R Elliot, A Wilt, J Sebastian, MA Haugan, T Varanasi, CV AF Wu, Judy Shi, Jack Baca, Javier Emergo, Rose Elliot, Alan Wilt, Jamie Sebastian, Mary Ann Haugan, Timothy Varanasi, Chakrapani V. TI Probing Microscopic Strain Interplay Due to Impurity Doping and Vicinal Growth and Its Effect on Pinning Landscape in YBCO Films SO IEEE TRANSACTIONS ON APPLIED SUPERCONDUCTIVITY LA English DT Article DE Doping; flux pinning; microstructure; strain; superconducting thin films ID EPITAXIAL YBA2CU3O7-DELTA FILMS; COLUMNAR DEFECTS; VORTEX MOTION; SUPERCONDUCTOR; DISPERSIONS; NANORODS; SPLAY AB Vortex pinning by insertion of non-superconducting defects like BZO or BSO nanorods into the YBCO matrix is an effective means to enhance pinning since they self-assemble into columnar structures that provide strong pinning along the length of the flux-line. However, only limited control of their geometry is possible by current growth methods. To meet the requirements of applications that operate in magnetic fields of varying intensity or orientation, this work studies strain-mediated self-assembly of 3D pinning landscape through theoretical modeling as well as experimental exploration to achieve controllable growth BZO or BSO nanostructures in YBCO matrix films. The microstructure of BZO- and BSO-doped YBCO thin films was studied using transmission electron microscopy and the findings indicate that it is possible to produce a controllable defect landscape and improved critical current density with respect to different orientation of the magnetic field by manipulation of the strain relationships using vicinal substrates. C1 [Wu, Judy; Shi, Jack; Baca, Javier; Emergo, Rose; Elliot, Alan; Wilt, Jamie] Univ Kansas, Dept Phys & Astron, Lawrence, KS 66045 USA. [Sebastian, Mary Ann; Haugan, Timothy] US Air Force Res Lab, Prop Directorate, Dayton, OH 45433 USA. [Varanasi, Chakrapani V.] Army Res Off, Adelphi, MD 20783 USA. RP Wu, J (reprint author), Univ Kansas, Dept Phys & Astron, Lawrence, KS 66045 USA. EM jwu@ku.edu FU ARO [W911NF-12-1-0412]; NSF [NSF-DMR-1105986, EPSCoR-0903806]; State of Kansas through Kansas Technology Enterprise Corporation FX This work was supported in part by the ARO Grant W911NF-12-1-0412, by the NSF under Contracts NSF-DMR-1105986 and NSF EPSCoR-0903806, and matching support from the State of Kansas through Kansas Technology Enterprise Corporation. NR 19 TC 1 Z9 1 U1 2 U2 40 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1051-8223 EI 1558-2515 J9 IEEE T APPL SUPERCON JI IEEE Trans. Appl. Supercond. PD JUN PY 2015 VL 25 IS 3 AR 8000205 DI 10.1109/TASC.2014.2369735 PG 5 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA CA7RZ UT WOS:000349116100018 ER PT J AU Schrock, JA Ray, WB Lawson, K Bilbao, A Bayne, SB Holt, SL Cheng, L Palmour, JW Scozzie, C AF Schrock, James A. Ray, William B., II Lawson, Kevin Bilbao, Argenis Bayne, Stephen B. Holt, Shad L. Cheng, Lin Palmour, John W. Scozzie, Charles TI High-Mobility Stable 1200-V, 150-A 4H-SiC DMOSFET Long-Term Reliability Analysis Under High Current Density Transient Conditions SO IEEE TRANSACTIONS ON POWER ELECTRONICS LA English DT Article DE DMOSFET; high current density; reliability testing; 4H-SiC ID HIGH-TEMPERATURE APPLICATIONS; SIC POWER DEVICES; LARGE-AREA; PERFORMANCE; MOSFETS; VOLTAGE AB For SiC DMOSFETs to obtain widespread usage in power electronics their long-term operational ability to handle the stressful transient current and high temperatures common in power electronics needs to be further verified. To determine the long-term reliability of a single 4H-SiC DMOSFET, the effects of extreme high current density were evaluated. The 4H-SiC DMOSFET has an active conducting area of 40 mm(2), and is rated for 1200 V and 150 A. The device was electrically stressed by hard-switching transient currents in excess of four times the given rating (>600 A) corresponding to a current density of 1500 A/cm(2). Periodically throughout testing, several device characteristics including R-DS(on) and V-GS(th) were measured. After 500 000 switching cycles, the device showed a 6.77% decrease in R-DS(on), and only a 132-mV decreased in V-GS(th). Additionally, the dc characteristics of the device were analyzed from 25 to 150 degrees C and revealed a 200-mV increase in on-state voltage drop at 20 A and a 2-V reduction in V-GS(th) at 150 degrees C. These results show this SiC DMOSFET has robust long-term reliability in high-power applications that are susceptible to pulse over currents, such as pulsed power modulators and hard-switched power electronics. C1 [Schrock, James A.; Ray, William B., II; Lawson, Kevin; Bilbao, Argenis; Bayne, Stephen B.; Holt, Shad L.] Texas Tech Univ, Ctr Pulsed Power & Power Elect, Lubbock, TX 79409 USA. [Cheng, Lin; Palmour, John W.] Cree Inc, Durham, NC 27703 USA. [Scozzie, Charles] Army Res Lab, Adelphi, MD 20783 USA. RP Schrock, JA (reprint author), Texas Tech Univ, Ctr Pulsed Power & Power Elect, Lubbock, TX 79409 USA. EM james.schrock@ttu.edu; w.ray@ttu.edu; kevin.lawson@ttu.edu; argenis.bilbao@ttu.edu; stephen.bayne@ttu.edu; shad.holt@ttu.edu; lin_cheng@cree.com; john_palmour@cree.com; charles.j.scozzie.civ@mail.mil NR 23 TC 7 Z9 7 U1 0 U2 35 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0885-8993 EI 1941-0107 J9 IEEE T POWER ELECTR JI IEEE Trans. Power Electron. PD JUN PY 2015 VL 30 IS 6 BP 2891 EP 2895 DI 10.1109/TPEL.2014.2357013 PG 5 WC Engineering, Electrical & Electronic SC Engineering GA AZ4PW UT WOS:000348205700002 ER PT J AU Villarreal-Trevino, C Vasquez, GM Lopez-Sifuentes, VM Escobedo-Vargas, K Huayanay-Repetto, A Linton, YM Flores-Mendoza, C Lescano, AG Stell, FM AF Villarreal-Trevino, Cuauhtemoc Vasquez, Gissella M. Lopez-Sifuentes, Victor M. Escobedo-Vargas, Karin Huayanay-Repetto, Anibal Linton, Yvonne-Marie Flores-Mendoza, Carmen Lescano, Andres G. Stell, Frederick M. TI Establishment of a free-mating, long-standing and highly productive laboratory colony of Anopheles darlingi from the Peruvian Amazon SO MALARIA JOURNAL LA English DT Article DE Anopheles darlingi; Colony establishment; Natural copulation induction; Larval rearing; Amazon basin; Peru; Malaria vector ID NEOTROPICAL MALARIA VECTOR; PLASMODIUM-VIVAX; BODY-SIZE; BRAZIL; COLONIZATION; TRANSMISSION; CULICIDAE; FECUNDITY; DIPTERA; AREA AB Background: Anopheles darlingi is the main malaria vector in the Amazon region and is among the most efficient malaria vectors worldwide. However, due to the lack of a well-established laboratory colony, key control-relevant aspects of the bionomics, behaviour, genetics, and vector-parasite relationships of An. darlingi remain unknown. Here, biological parameters that had been successful in initiating other Anopheles colonies were optimized and improved for An. darlingi, with the aim of establish a free-mating, stable, and highly productive laboratory colony. Methods: Wild An. darlingi adult females were field collected from Zungarococha, Loreto Department, Peru (03 degrees 49' 32.40 '' S, 73 degrees 21'00.08 '' W), and taken to the NAMRU-6 Insectary in Iquitos where F-1 offspring were produced and reared. Natural copulation was successfully induced in F1 adults under a thermoperiod of 30 +/- 1 degrees C during the day and 25 +/- 1 degrees C at night, and with a 30-min LED light stimulation period at dusk. Oviposition success was enhanced using egg-laying containers with a dark-coloured surface. Larval feeding regimes were standardized for optimal larval development. Optimized copulation induction methods were used to facilitate mating in An. darlingi until the F-10 generation. No copulation induction assistance was needed in subsequent generations. Results: In 19 generations, the An. darlingi colony produced a total of 763,775 eggs; 441,124 larvae; 248,041 pupae; and 231,591 adults. A mean of 0.56 sexual encounters/female/cage (n = 36 cages) was recorded across the first ten generations (F-1-F-10). A mean insemination rate of 54.7 % (n = 5,907 females) ranging from 43.6 % (F-2) to 66.6 % (F-10) was recorded across nine generations (F-2-F-10). Free-mating was casually observed in the F-8 generation, and subsequently confirmed in the F-9 and F-10 generations; comparable insemination rates and egg laying between stimulated (51.6 %, 12.9 eggs/female), and non-stimulated (52.3 %, 11.2 eggs/female) females were recorded. The time from egg to adult development ranged from 10 to 20 days. Moreover, the colony was relocated to a new laboratory within Iquitos in the F-14 generation without any noted changes in its productivity. By March 2015, the An. darlingi colony has been successfully reared to the F-26 generation. Conclusions: This constitutes the first report of a free-mating, highly productive, and long-standing An. darlingi laboratory colony established through natural copulation induction, which will support critical malaria research. This rearing methodology may be a transferable, cost-effective alternative to labour-intensive forced mating practices widely used in maintaining other Anopheles colonies. C1 [Villarreal-Trevino, Cuauhtemoc] US Naval Med Res Unit 6 NAMRU 6, Dept Entomol, Bellavista, Callao, Peru. [Vasquez, Gissella M.; Lopez-Sifuentes, Victor M.; Escobedo-Vargas, Karin; Huayanay-Repetto, Anibal; Flores-Mendoza, Carmen; Stell, Frederick M.] US Naval Med Res Unit 6, Dept Entomol, Bellavista, Callao, Peru. [Linton, Yvonne-Marie] Smithsonian Inst, Museum Support Ctr, Walter Reed Biosystemat Unit, Suitland, MD USA. [Linton, Yvonne-Marie] Walter Reed Army Inst Res, Silver Spring, MD USA. [Linton, Yvonne-Marie] Smithsonian Inst, Dept Entomol, Washington, DC 20560 USA. [Lescano, Andres G.] US Naval Med Res Unit 6, Dept Parasitol, Bellavista, Callao, Peru. RP Vasquez, GM (reprint author), US Naval Med Res Unit 6 NAMRU 6, Dept Entomol, Bellavista, Callao, Peru. EM gissella.vasquez@med.navy.mil RI Lescano, Andres/B-8479-2008 OI Lescano, Andres/0000-0001-9779-633X FU Contrato de Acceso Marco a Recursos Geneticos [0017-2014-MINAGRI-DGFFS/DGEFFS]; Global Emerging Infections Surveillance and Response System (AFHSC/GEIS) of the U.S. Department of Defense sustainment funding award; Consejo Nacional de Ciencia y Tecnologia (CONACYT) Mexico [CB2008-105806-M]; Fogarty International Center of the U.S. National Institutes of Health [2D43 TW007393-06]; National Research Council (NRC) Research Associate Program FX We would like to thank the Ministerio de Agricultura y Riego de Peru, Direccion General Forestal y de Fauna Silvestre, and the Direccion de Salud, Gobierno Regional de Loreto for permission to conduct these studies: Anopheles darlingi collections in Loreto were conducted under the auspices of Resolucion Directoral No. 0406-2013-MINAGRI-DGFFS/DGEFFS; An. darlingi molecular identification was conducted under the auspices of Contrato de Acceso Marco a Recursos Geneticos No. 0017-2014-MINAGRI-DGFFS/DGEFFS. We would like to thank Fanny Castro, Geidin Chavez, Hugo Jaba, Luz Romero, Miguel Vasquez, and Alex Vasquez for technical support. Additionally, we would like to thank Dr. Craig Stoops for providing helpful comments on the manuscript. Financial support was provided by the Global Emerging Infections Surveillance and Response System (AFHSC/GEIS) of the U.S. Department of Defense sustainment funding award (FMS, GMV), the Consejo Nacional de Ciencia y Tecnologia (CONACYT) Mexico, grant CB2008-105806-M (CVT), and by the training grant 2D43 TW007393-06 awarded to NAMRU-6 by the Fogarty International Center of the U.S. National Institutes of Health. YML was supported by the National Research Council (NRC) Research Associate Program. NR 40 TC 3 Z9 3 U1 1 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD MAY 30 PY 2015 VL 14 AR 227 DI 10.1186/s12936-015-0733-0 PG 12 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA CK4UZ UT WOS:000356220100001 PM 26024853 ER PT J AU Maswadeh, WM Snyder, AP AF Maswadeh, Waleed M. Snyder, A. Peter TI Variable ranking based on the estimated degree of separation for two distributions of data by the length of the receiver operating characteristic curve SO ANALYTICA CHIMICA ACTA LA English DT Article DE Degree of separation; Variable ranking; Probability density function; Length of receiver operating characteristic curve; Area between receiver operating; characteristic curve and diagonal ID CHARACTERISTIC ROC CURVE; RAMAN-SPECTROSCOPY; AREA; SELECTION AB Variable responses are fundamental for all experiments, and they can consist of information-rich, redundant, and low signal intensities. A dataset can consist of a collection of variable responses over multiple classes or groups. Usually some of the variables are removed in a dataset that contain very little information. Sometimes all the variables are used in the data analysis phase. It is common practice to discriminate between two distributions of data; however, there is no formal algorithm to arrive at a degree of separation (DS) between two distributions of data. The DS is defined herein as the average of the sum of the areas from the probability density functions (PDFs) of A and B that contain a >= percentage of A and/or B. Thus, DS90 is the average of the sum of the PDF areas of A and B that contain >= 90% of A and/or B. To arrive at a DS value, two synthesized PDFs or very large experimental datasets are required. Experimentally it is common practice to generate relatively small datasets. Therefore, the challenge was to find a statistical parameter that can be used on small datasets to estimate and highly correlate with the DS90 parameter. Established statistical methods include the overlap area of the two data distribution profiles, Welch's t-test, Kolmogorov-Smirnov (K-S) test, Mann-Whitney-Wilcoxon test, and the area under the receiver operating characteristics (ROC) curve (AUC). The area between the ROC curve and diagonal (ACD) and the length of the ROC curve (LROC) are introduced. The established, ACD, and LROC methods were correlated to the DS90 when applied on many pairs of synthesized PDFs. The LROC method provided the best linear correlation with, and estimation of, the DS90. The estimated DS90 from the LROC (DS90-LROC) is applied to a database, as an example, of three Italian wines consisting of thirteen variable responses for variable ranking consideration. An important highlight of the DS90-LROC method is utilizing the LROC curve methodology to test all variables one-at-a-time with all pairs of classes in a dataset. (C) 2015 Elsevier B.V. All rights reserved. C1 [Maswadeh, Waleed M.] US Army, Army Edgewood Chem Biol Ctr ECBC, RDECOM, Edgewood Area,ATTN RDCB DRD P, Aberdeen Proving Ground, MD 21010 USA. RP Maswadeh, WM (reprint author), US Army, Army Edgewood Chem Biol Ctr ECBC, RDECOM, Edgewood Area,ATTN RDCB DRD P, Bldg E3160, Aberdeen Proving Ground, MD 21010 USA. EM waleed.m.maswadeh.civ@mail.mil FU Edgewood Chemical Biological Center (ECBC) FX The authors wish to thank the Edgewood Chemical Biological Center (ECBC) for funding the project. NR 28 TC 1 Z9 1 U1 1 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0003-2670 EI 1873-4324 J9 ANAL CHIM ACTA JI Anal. Chim. Acta PD MAY 30 PY 2015 VL 876 BP 39 EP 48 DI 10.1016/j.aca.2015.03.024 PG 10 WC Chemistry, Analytical SC Chemistry GA CI5FW UT WOS:000354780400004 PM 25998456 ER PT J AU Sviatenko, LK Isayev, O Gorb, L Hill, FC Leszczynska, D Leszczynski, J AF Sviatenko, Liudmyla K. Isayev, Olexandr Gorb, Leonid Hill, Frances C. Leszczynska, Danuta Leszczynski, Jerzy TI Are the Reduction and Oxidation Properties of Nitrocompounds Dissolved in Water Different From Those Produced When Adsorbed on a Silica Surface? A DFT M05-2X Computational Study SO JOURNAL OF COMPUTATIONAL CHEMISTRY LA English DT Article DE silica; adsorption; reduction; oxidation; nitrocompounds ID ZERO-VALENT IRON; CLAY-MINERALS; FENTON OXIDATION; AB-INITIO; TNT; 2,4,6-TRINITROTOLUENE; ADSORPTION; EXPLOSIVES; POTENTIALS; METAL AB The reduction and oxidation properties of four nitrocompounds (trinitrotoluene [TNT], 2,4-dinitrotoluene, 2,4-dinitroanisole, and 5-nitro-2,4-dihydro-3H-1,2,4-triazol-3-one [NTO]) dissolved in water as compared with the same properties for compounds adsorbed on a silica surface were studied. To consider the influence of adsorption, cluster models were developed at the M05/tzvp level. A hydroxylated silica (001) surface was chosen to represent a key component of soil. The PCM(Pauling) and SMD solvation models were used to model water bulk influence. The following properties were analyzed: electron affinity, ionization potential, reduction Gibbs free energy, oxidation Gibbs free energy, and reduction and oxidation potentials. It was found that adsorption and solvation decrease gas phase electron affinity, ionization potential, and Gibbs free energy of reduction and oxidation, and thus, promote redox transformation of nitrocompounds. However, in case of solvation, the changes are more significant than for adsorption. This means that nitrocompounds dissolved in water are easier to transform by reduction or oxidation than adsorbed ones. Among the considered compounds, TNT was found to be the most reactive in an electron attachment process and the least reactive for an electron detachment transformation. During ionization, a deprotonation of adsorbed NTO was found to occur. (c) 2015 Wiley Periodicals, Inc. C1 [Sviatenko, Liudmyla K.; Leszczynski, Jerzy] Jackson State Univ, Dept Chem & Biochem, Interdisciplinary Nanotox Ctr, Jackson, MS 39217 USA. [Sviatenko, Liudmyla K.] Oles Honchar Dnipropetrovsk Natl Univ, Dept Organ Chem, UA-49010 Dnepropetrovsk, Ukraine. [Isayev, Olexandr] Univ N Carolina, Div Chem Biol & Med Chem, UNC Eshelman Sch Pharm, Chapel Hill, NC 27599 USA. [Gorb, Leonid] Badger Tech Serv Inc, Huntsville, AL 35805 USA. [Hill, Frances C.] US Army ERDC, Environm Lab, Vicksburg, MS 39180 USA. [Leszczynska, Danuta] Jackson State Univ, Dept Civil & Environm Engn, Interdisciplinary Nanotox Ctr, Jackson, MS 39217 USA. RP Leszczynski, J (reprint author), Jackson State Univ, Dept Chem & Biochem, Interdisciplinary Nanotox Ctr, Jackson, MS 39217 USA. EM jerzy@icnanotox.org FU ERDC [W912HZ-13-P-0037]; National Science Foundation [OCI-1053575]; XSEDE Award [DMR110088] FX Contract grant sponsor: ERDC; Contract grant number: W912HZ-13-P-0037; Contract grant sponsor: National Science Foundation; contract grant number: OCI-1053575; Contract grant sponsor: XSEDE Award; Contract grant number: DMR110088 NR 52 TC 5 Z9 5 U1 4 U2 24 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0192-8651 EI 1096-987X J9 J COMPUT CHEM JI J. Comput. Chem. PD MAY 30 PY 2015 VL 36 IS 14 BP 1029 EP 1035 DI 10.1002/jcc.23878 PG 7 WC Chemistry, Multidisciplinary SC Chemistry GA CH3HR UT WOS:000353921100001 PM 25736204 ER PT J AU Touryan, J Mazer, JA AF Touryan, Jon Mazer, James A. TI Linear and non-linear properties of feature selectivity in V4 neurons SO FRONTIERS IN SYSTEMS NEUROSCIENCE LA English DT Article DE feature selectivity; extra-striate visual cortex; receptive field; natural scenes; Gaussian bubbles ID MACAQUE AREA V4; CLASSICAL RECEPTIVE-FIELD; INFERIOR TEMPORAL CORTEX; CAT STRIATE CORTEX; NATURAL IMAGES; VISUAL-CORTEX; SHAPE REPRESENTATION; SPATIAL STRUCTURE; CEREBRAL-CORTEX; RESPONSES AB Extrastriate area V4 is a critical component of visual form processing in both humans and non-human primates. Previous studies have shown that the tuning properties of V4 neurons demonstrate an intermediate level of complexity that lies between the narrow band orientation and spatial frequency tuning of neurons in primary visual cortex and the highly complex object selectivity seen in inferotemporal neurons. However, the nature of feature selectivity within this cortical area is not well understood, especially in the context of natural stimuli. Specifically, little is known about how the tuning properties of V4 neurons, measured in isolation, translate to feature selectivity within natural scenes. In this study, we assessed the degree to which preferences for natural image components can readily be inferred from classical orientation and spatial frequency tuning functions. Using a psychophysically-inspired method we isolated and identified the specific visual "driving features" occurring in natural scene photographs that reliably elicited spiking activity from single V4 neurons. We then compared the measured driving features to those predicted based on the spectral receptive field (SRF), estimated from responses to narrowband sinusoidal grating stimuli. This approach provided a quantitative framework for assessing the degree to which linear feature selectivity was preserved during natural vision. First, we found evidence of both spectrally and spatially tuned suppression within the receptive field, neither of which were present in the linear SRF. Second, we found driving features that were stable during translation of the image across the receptive field (due to small fixational eye movements). The degree of translation invariance fell along a continuum, with some cells showing nearly complete invariance across the receptive field and others exhibiting little to no position invariance. This form of limited translation invariance could indicate that a subset of V4 neurons are insensitive to small fixational eye movements, supporting perceptual stability during natural vision. C1 [Touryan, Jon; Mazer, James A.] Yale Univ, Sch Med, Dept Neurobiol, New Haven, CT 06520 USA. [Touryan, Jon] US Army Res Lab, Human Res & Engn Directorate, Aberdeen, MD USA. [Mazer, James A.] Yale Univ, Dept Psychol, New Haven, CT 06520 USA. RP Mazer, JA (reprint author), Yale Univ, Sch Med, Dept Neurobiol, POB 208001, New Haven, CT 06520 USA. EM james.mazer@yale.edu FU NINDS NIH HHS [T32 NS007224] NR 53 TC 0 Z9 0 U1 2 U2 5 PU FRONTIERS MEDIA SA PI LAUSANNE PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLAND SN 1662-5137 J9 FRONT SYST NEUROSCI JI Front. Syst. Neurosci. PD MAY 27 PY 2015 VL 9 AR 82 DI 10.3389/fnsys.2015.00082 PG 12 WC Neurosciences SC Neurosciences & Neurology GA CU9AX UT WOS:000363836300001 PM 26074788 ER PT J AU Frevert, U Krzych, U AF Frevert, Ute Krzych, Urszula TI Plasmodium cellular effector mechanisms and the hepatic microenvironment SO FRONTIERS IN MICROBIOLOGY LA English DT Review DE Plasmodium; liver; antigen-presenting cells; CD8 T cells; liver lymphatics ID CD8(+) T-CELLS; MALARIA CIRCUMSPOROZOITE PROTEIN; LIVER-STAGE MALARIA; SINUSOIDAL-ENDOTHELIAL-CELLS; NITRIC-OXIDE SYNTHASE; RIBOSOME-INACTIVATING PROTEINS; INTERFERON-GAMMA; KUPFFER-CELLS; IN-VIVO; DENDRITIC CELLS AB Plasmodium falciparum malaria remains one of the most serious health problems globally. Immunization with attenuated parasites elicits multiple cellular effector mechanisms capable of eliminating Plasmodium liver stages. However, malaria liver stage (LS) immunity is complex and the mechanisms effector T cells use to locate the few infected hepatocytes in the large liver in order to kill the intracellular LS parasites remain a mystery to date. Here, we review our current knowledge on the behavior of CD8 effector T cells in the hepatic microvasculature, in malaria and other hepatic infections. Taking into account the unique immunological and lymphogenic properties of the liver, we discuss whether classical granule-mediated cytotoxicity might eliminate infected hepatocytes via direct cell contact or whether cytokines might operate without cell cell contact and kill Plasmodium LSs at a distance. A thorough understanding of the cellular effector mechanisms that lead to parasite death hence sterile protection is a prerequisite for the development of a successful malaria vaccine to protect the 40% of the world's population currently at risk of Plasmodium infection. C1 [Frevert, Ute] NYU, Sch Med, Dept Microbiol, Div Med Parasitol, New York, NY 10010 USA. [Krzych, Urszula] Walter Reed Army Inst Res, Dept Cellular Immunol, Div Malaria Vaccine Dev, Silver Spring, MD USA. RP Frevert, U (reprint author), NYU, Sch Med, Dept Microbiol, Div Med Parasitol, 341 E 25 St, New York, NY 10010 USA. EM ute.frevert@nyumc.org; ukrzych@gmail.com FU NIH [RO1 AI070894, S10 RR019288, RO1 AI46438]; US Army Research and Materiel Command FX The authors would like to express their gratitude to all the past and the present members of the Frevert and Krzych Labs for many useful discussions about malaria and the liver. Work presented in this review was partly supported by a NIH grants RO1 AI070894 and S10 RR019288 (UF) and by NIH grant RO1 AI46438 and US Army Research and Materiel Command (UK). The opinions or assertions contained herein are the private views of the authors, and are not to be construed as official, or as reflecting true views of the Department of the Army or the Department of Defense. NR 217 TC 11 Z9 11 U1 1 U2 7 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND SN 1664-302X J9 FRONT MICROBIOL JI Front. Microbiol. PD MAY 27 PY 2015 VL 6 AR 482 DI 10.3389/fmicb.2015.00482 PG 19 WC Microbiology SC Microbiology GA CK5SE UT WOS:000356285200001 PM 26074888 ER PT J AU Di Battista, AP Buonora, JE Rhind, SG Hutchison, MG Baker, AJ Rizoli, SB Diaz-Arrastia, R Mueller, GP AF Di Battista, Alex P. Buonora, John E. Rhind, Shawn G. Hutchison, Michael G. Baker, Andrew J. Rizoli, Sandro B. Diaz-Arrastia, Ramon Mueller, Gregory P. TI Blood biomarkers in moderate-to-severe traumatic brain injury: potential utility of a multi-marker approach in characterizing outcome SO FRONTIERS IN NEUROLOGY LA English DT Article DE s100B; GFAP; NSE; BDNF; MCP-1; ICAM-5; PRDX-6 ID NEURON-SPECIFIC ENOLASE; NEUROTROPHIC FACTOR; PROGNOSTIC VALUE; S100B LEVELS; SERUM; PROTEIN; MCP-1; HEAD; NEUROINFLAMMATION; INFLAMMATION AB Background: Blood biomarkers are valuable tools for elucidating complex cellular and molecular mechanisms underlying traumatic brain injury (TBI). Profiling distinct classes of biomarkers could aid in the identification and characterization of initial injury and secondary pathological processes. This study characterized the prognostic performance of a recently developed multi-marker panel of circulating biomarkers that reflect specific pathogenic mechanisms including neuroinflammation, oxidative damage, and neuroregeneration, in moderate-to-severe TBI patients. Materials and methods: Peripheral blood was drawn from 85 isolated TBI patients (n = 60 severe, n = 25 moderate) at hospital admission, 6-, 12-, and 24-h post-injury. Mortality and neurological outcome were assessed using the extended Glasgow Outcome Scale. A multiplex platform was designed on MULTI-SPOT plates to simultaneously analyze human plasma levels of s100 calcium binding protein beta (s100B), glial fibrillary acidic protein (GFAP), neuron specific enolase (NSF), brain-derived neurotrophic factor (BDNF), monocyte chemoattractant protein (MCP)-1, intercellular adhesion molecule (ICAM)-5, and peroxiredoxin (PRDX)-6. Multivariable logistic regression and area under the receiver-operating characteristic curve (AUC) were used to evaluate both individual and combined predictive abilities of these markers for 6-month neurological outcome and mortality after TBI. Results: Unfavorable neurological outcome was associated with elevations in s100B, GFAP, and MCP-1. Mortality was related to differences in six of the seven markers analyzed. Combined admission concentrations of s100B, GFAP, and MCP-1 were able to discriminate favorable versus unfavorable outcome (AUC = 0.83), and survival versus death (AUG = 0.87), although not significantly better than s100B alone (AUG = 0.82 and 0.86, respectively). Conclusion: The multi-marker panel of TBI-related biomarkers performed well in discriminating unfavorable and favorable outcomes in the acute period after moderateto-severe TBI. However, the combination of these biomarkers did not outperform s100B alone. C1 [Di Battista, Alex P.; Baker, Andrew J.; Rizoli, Sandro B.] Univ Toronto, Inst Med Sci, Fac Med, Toronto, ON M3K 2C9, Canada. [Di Battista, Alex P.; Rhind, Shawn G.] Toronto Res Ctr, Def Res & Dev Canada, Toronto, ON, Canada. [Di Battista, Alex P.; Baker, Andrew J.; Rizoli, Sandro B.] St Michaels Hosp, Li Ka Shing Knowledge Inst, Keenan Res Ctr, Toronto, ON M5B 1W8, Canada. [Buonora, John E.; Mueller, Gregory P.] Univ Hlth Sci, Uniformed Serv, Dept Anat Physiol & Genet, Bethesda, MD USA. [Buonora, John E.] US Army, Grad Program Anesthesia Nursing, Ft Sam Houston, TX USA. [Rhind, Shawn G.; Hutchison, Michael G.] Univ Toronto, Fac Kinesiol & Phys Educ, David L Maclntosh Sport Med Clin, Toronto, ON, Canada. [Baker, Andrew J.; Rizoli, Sandro B.] Univ Toronto, Dept Anesthesia, Toronto, ON, Canada. [Baker, Andrew J.; Rizoli, Sandro B.] Univ Toronto, Dept Surg & Crit Care Med, Toronto, ON, Canada. [Diaz-Arrastia, Ramon] Uniformed Serv Univ Hlth Sci, Ctr Neurosci & Regenerat Med, Bethesda, MD 20814 USA. RP Di Battista, AP (reprint author), Univ Toronto, Inst Med Sci, Fac Med, 1133 Sheppard Ave West, Toronto, ON M3K 2C9, Canada. EM alex.dibattista@mail.utoronto.ca FU Defence Research and Development Canada Technology Investment Fund Programme; Center for Neuroscience and Regenerative Medicine; Tr-Service Nursing Research Program [HT9404-12-1-T513] FX The authors gratefully acknowledge the technical assistance of Ms. Maria Shiu and Mr. Shahid Hassan. This research was funded by the Defence Research and Development Canada Technology Investment Fund Programme, the Center for Neuroscience and Regenerative Medicine, and the Tr-Service Nursing Research Program, Grant #HT9404-12-1-T513. NR 51 TC 15 Z9 15 U1 2 U2 4 PU FRONTIERS MEDIA SA PI LAUSANNE PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLAND SN 1664-2295 J9 FRONT NEUROL JI Front. Neurol. PD MAY 26 PY 2015 VL 6 AR 110 DI 10.3389/fneur.2015.00110 PG 9 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA CU9DC UT WOS:000363842300002 PM 26074866 ER PT J AU Mukhopadhyay, S Thompson, T Sakamoto, J Huq, A Wolfenstine, J Allen, JL Bernstein, N Stewart, DA Johannes, MD AF Mukhopadhyay, Saikat Thompson, Travis Sakamoto, Jeff Huq, Ashfia Wolfenstine, Jeff Allen, Jan L. Bernstein, Noam Stewart, Derek A. Johannes, M. D. TI Structure and Stoichiometry in Supervalent Doped Li7La3Zr2O12 SO CHEMISTRY OF MATERIALS LA English DT Article ID GARNET-TYPE LI7LA3ZR2O12; LITHIUM ION CONDUCTORS; AUGMENTED-WAVE METHOD; CUBIC LI7LA3ZR2O12; CRYSTAL-STRUCTURE; CONDUCTIVITY; OXIDES; TA; LI-7-XLA3ZR2-XTAXO12; ELECTROLYTES AB The oxide garnet material L(i)7La(3)Zr(2)O(12) shows remarkably high ionic conductivity when doped with supervalent ions that are charge compensated by Li vacancies and is currently one of the best candidates for development of a technologically relevant solid electrolyte. Determination of optimal dopant concentration, however, has remained a persistent problem due to the extreme difficulty of establishing the actual (as compared to nominal) stoichiometry of intentionally doped materials and by the fact that it is still not entirely clear what level of lattice expansion/contraction best promotes. ionic diffusion. By combining careful synthesis, neutron diffraction, high-resolution X-ray diffraction (XRD), Raman measurements, and density functional theory calculations, we show that structure and stoichiometry are intimately related such that the former can in many cases be used as a gauge of the latter. We show that different Li-vacancy creating supervalent ions (Al3+ vs Ta5+) affect the structure very differently, both in terms of the lattice constant, which is easily measurable, and hi terms of the local structure, which can be difficult or impossible to access experimentally but may have important ramifications for conduction. We carefully correlate the lattice constant to dopant type/concentration via Vegard's law and then further correlate these quantities to relevant local structural parameters. Our work opens the possibility of developing a codopant scheme that optimizes the Li vacancy concentration and the lattice size simultaneously. C1 [Mukhopadhyay, Saikat; Stewart, Derek A.] Cornell Univ, Cornell Nanoscale Facil, Ithaca, NY 14853 USA. [Thompson, Travis; Sakamoto, Jeff] Michigan State Univ, Dept Chem Engn & Mat Sci, E Lansing, MI 48824 USA. [Huq, Ashfia] Oak Ridge Natl Lab, Oak Ridge, TN 37830 USA. [Wolfenstine, Jeff; Allen, Jan L.] Army Res Lab, Adelphi, MD 20783 USA. [Bernstein, Noam; Johannes, M. D.] Naval Res Lab, Ctr Computat Mat Sci, Washington, DC 20375 USA. RP Johannes, MD (reprint author), Naval Res Lab, Ctr Computat Mat Sci, 4555 Overlook Ave SW, Washington, DC 20375 USA. EM michelle.johannes@nrl.navy.mil RI Stewart, Derek/B-6115-2008; Huq, Ashfia/J-8772-2013; Mukhopadhyay, Saikat/B-4402-2011; OI Huq, Ashfia/0000-0002-8445-9649; Stewart, Derek/0000-0001-7355-2605 FU NSF CBET [1066406]; Office of Naval Research through the Naval Research Laboratory's Basic Research Program; Scientific User Facilities Division, Office of Basic Energy Sciences, U.S. Department of Energy; Revolutionary Materials for Solid State Energy Conversion, an Energy Frontier Research Center - US Department of Energy, Office of Science, Office of Basic Energy Science [DE-SC001054]; U.S. Army Research Laboratory (ARL) FX We thankfully acknowledge computing resources from the NNIN/C at Cornell and Research Services at Boston College. The work at Cornell University was supported by NSF CBET Grant via contract numbers 1066406. Funding for M.D.J. and N.B. was provided by the Office of Naval Research through the Naval Research Laboratory's Basic Research Program. A portion of this research at ORNL's Spallation Neutron Source was sponsored by the Scientific User Facilities Division, Office of Basic Energy Sciences, U.S. Department of Energy. T.T. and J.S. would like to acknowledge support from the Revolutionary Materials for Solid State Energy Conversion, an Energy Frontier Research Center funded by the US Department of Energy, Office of Science, Office of Basic Energy Science under Award Number DE-SC001054. J.W. and J.L.A. would like to acknowledge support of the U.S. Army Research Laboratory (ARL). NR 48 TC 10 Z9 10 U1 18 U2 101 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0897-4756 EI 1520-5002 J9 CHEM MATER JI Chem. Mat. PD MAY 26 PY 2015 VL 27 IS 10 BP 3658 EP 3665 DI 10.1021/acs.chemmater.5b00362 PG 8 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA CJ3KP UT WOS:000355382700014 ER PT J AU Seifu, D Neupane, S Giri, L Karna, SP Hong, HP Seehra, MS AF Seifu, Dereje Neupane, Suman Giri, Lily Karna, Shashi P. Hong, Haiping Seehra, M. S. TI Multilayered graphene acquires ferromagnetism in proximity with magnetite particles SO APPLIED PHYSICS LETTERS LA English DT Article ID ROOM-TEMPERATURE FERROMAGNETISM; CARBON NANOTUBES; GRAPHITE; DENSITY; FILMS AB Anisotropic diamagnetism of pristine graphite and graphene is well known. Here, evidence of significant induced ferromagnetism in multilayer graphene (MLG) decorated with ferrimagnetic Fe3O4 particles is reported. This MLG-Fe3O4 nano-composite was prepared by a one-step ultrasonic treatment at 75 degrees C in the surfactant sodium dodecyl-benzene-sulfonate. To verify the phase structure and morphology of the composite, X-ray diffraction, scanning and transmission electron microscopy, scanning tunneling electron microscopy, and Raman spectroscopy were employed. Room temperature data of magnetization versus magnetic field showed that the saturation magnetization M-S = 58.6 emu/gm for pristine Fe3O4 increased to M-S = 158.4 emu/gm for a 1:1 composite of Fe3O4 to MLG. These results lead to induced M-S = 253 emu/gm in MLG resulting from its proximity to Fe3O4. Similar experiments on Fe3O4 to single walled carbon nanotubes (SWNT) composite did not show any induced magnetism in SWNT. (C) 2015 AIP Publishing LLC. C1 [Seifu, Dereje; Neupane, Suman] Morgan State Univ, Dept Phys, Baltimore, MD 21251 USA. [Giri, Lily; Karna, Shashi P.] Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Hong, Haiping] South Dakota Sch Mines & Technol, Dept Mat & Met Engn, Rapid City, SD 57701 USA. [Seehra, M. S.] Univ Virginia, Dept Phys & Astron, Morgantown, WV 26506 USA. RP Seifu, D (reprint author), Morgan State Univ, Dept Phys, Baltimore, MD 21251 USA. EM Dereje.seifu@morgan.edu FU U.S. Army Research Laboratory [USARMY-W911NF-12-2-0041]; NSF-MRI-R2 grant [0958950]; NSF-MRI [1337339] FX One of the authors, Dereje Seifu, would like to acknowledge the supports of the U.S. Army Research Laboratory through a Cooperative Research Agreement USARMY-W911NF-12-2-0041, NSF-MRI-R2 grant (Award No. 0958950), and NSF-MRI (Award No. 1337339). NR 29 TC 3 Z9 3 U1 10 U2 45 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAY 25 PY 2015 VL 106 IS 21 AR 212401 DI 10.1063/1.4921770 PG 5 WC Physics, Applied SC Physics GA CJ6UX UT WOS:000355631400020 ER PT J AU Mulligan, CP Wei, R Yang, G Zheng, P Deng, R Gall, D AF Mulligan, C. P. Wei, R. Yang, G. Zheng, P. Deng, R. Gall, D. TI Microstructure and age hardening of C276 alloy coatings SO SURFACE & COATINGS TECHNOLOGY LA English DT Article DE C276; PEMS; Corrosion-resistant alloy; X-ray diffraction; PVD ID HALL-PETCH RELATION; CR-MO ALLOYS; THERMAL-STABILITY; NANOCOMPOSITE COATINGS; HARDNESS; DEPOSITION AB C276 alloy layers were deposited on 4140 steel substrates by plasma enhanced magnetron sputtering. The as-deposited 12-mu m-thick coatings exhibit a face centered cubic nanocrystalline structure with a grain size of 37-46 nm and a uniform composition that replicates the C276 alloy deposition source. The as-deposited coating hardness H = 62 +/- 03 GPa is four times larger than the known bulk H = 1.5-1.9 GPa. This is attributed to the small grain size and associated Hall-Petch hardening. Annealing in air for 1 hat 600 degrees C, 700 degrees C, and 800 degrees C causes negligible changes in grain size but results in changes in microstructure and texture and a significant increase in H to 73-8.5 GPa. Compositional maps by Auger electron and energy-dispersive spectroscopies as well as a secondary x-ray diffraction peak suggest that this increase is due to segregation and precipitation of Cr- and Mo-rich regions. Published by Elsevier B.V. C1 [Mulligan, C. P.] US Army, Armament Res & Dev Ctr, Benet Labs, Watervliet, NY 12189 USA. [Wei, R.] SW Res Inst, San Antonio, TX 78238 USA. [Yang, G.; Zheng, P.; Deng, R.; Gall, D.] Rensselaer Polytech Inst, Dept Mat Sci & Engn, Troy, NY 12180 USA. [Yang, G.] Lanzhou Univ Technol, Sch Mat Sci & Engn, Lanzhou 730050, Peoples R China. RP Mulligan, CP (reprint author), US Army, Benet Labs, 1 Buffington St ATTN RDAR WSB LB,B 115, Watervliet, NY 12189 USA. RI Gall, Daniel/B-1060-2008 OI Gall, Daniel/0000-0002-5762-9307 FU NSF [1031201, 1309490] FX This research is supported by the NSF through grant nos. 1031201 and 1309490. NR 24 TC 1 Z9 1 U1 2 U2 12 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0257-8972 J9 SURF COAT TECH JI Surf. Coat. Technol. PD MAY 25 PY 2015 VL 270 BP 299 EP 304 DI 10.1016/j.surfcoat.2015.02.030 PG 6 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA CH6LZ UT WOS:000354149400037 ER PT J AU Greene, JM Schneble, EJ Martin, J Flores, M Berry, JS Trappey, AF Vreeland, TJ Hale, DF Sears, AK Clifton, GT von Hofe, E Symanowski, JT Ardavanis, A Shumway, NM Ponniah, S Papamichail, M Perez, SA Peoples, GE Mittendorf, EA AF Greene, Julia M. Schneble, Erika J. Martin, Jonathan Flores, Madeline Berry, John S. Trappey, Alfred F. Vreeland, Timothy J. Hale, Diane F. Sears, Alan K. Clifton, Guy T. von Hofe, Eric Symanowski, James Thomas Ardavanis, Alexandros Shumway, Nathan M. Ponniah, Sathibalan Papamichail, Michael Perez, Sonia A. Peoples, George Earl Mittendorf, Elizabeth Ann TI Final pre-specified analysis of the phase II trial of the AE37+GM-CSF vaccine in high risk breast cancer patients to prevent recurrence SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract CT Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO) CY MAY 29-JUN 02, 2015 CL Chicago, IL SP Amer Soc Clin Oncol C1 San Antonio Mil Med Ctr, San Antonio, TX USA. Brooke Army Med Ctr, San Antonio, TX USA. Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. Antigen Express, Worcester, MA USA. Levine Canc Inst Carolinas Healthcare Syst, Charlotte, NC USA. St Savvas Anticanc Hosp, Athens, Greece. Canc Vaccine Dev Program, Bethesda, MD USA. USUHS, Canc Vaccine Dev Program, United States Mil Canc Inst, Bethesda, MD USA. St Savas Canc Hosp, Canc Immunol & Immunotherapy Ctr, Athens, Greece. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X EI 1527-7755 J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAY 20 PY 2015 VL 33 IS 15 SU S MA 622 PG 1 WC Oncology SC Oncology GA CM9OA UT WOS:000358036901414 ER PT J AU Lazarus, N Meyer, CD Bedair, SS Slipher, GA Kierzewski, IM AF Lazarus, Nathan Meyer, Chris D. Bedair, Sarah S. Slipher, Geoffrey A. Kierzewski, Iain M. TI Magnetic Elastomers for Stretchable Inductors SO ACS APPLIED MATERIALS & INTERFACES LA English DT Article DE composite materials; stretchable electronics; magnetic materials; inductors AB In this work, silicone loaded with magnetic particles is investigated for creating a composite with higher permeability while still maintaining stretchability. Magnetic and mechanical properties are first characterized for composites based on both spherical and platelet particle geometries. The first magnetic-core stretchable inductors arethen demonstrated using the resulting ferroelastomer. Solenoid inductors based on liquid metal galinstan are then demonstrated around a ferroelastomeric cote and shown to Survive uniaxial strains up to 100%. Soft elastomers loaded With magnetic particles were found to increase the core permeability and inductance density of stretchable inductors by nearly 200%. C1 [Lazarus, Nathan; Meyer, Chris D.; Bedair, Sarah S.; Slipher, Geoffrey A.] US Army Res Lab, Adelphi, MD 20783 USA. [Kierzewski, Iain M.] Gen Tech Serv, Adelphi, MD 20783 USA. RP Lazarus, N (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM nathan.lazarus2.civ@mail.mil RI Slipher, Geoffrey/A-6365-2016 OI Slipher, Geoffrey/0000-0003-0532-0081 NR 28 TC 4 Z9 4 U1 7 U2 23 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1944-8244 J9 ACS APPL MATER INTER JI ACS Appl. Mater. Interfaces PD MAY 20 PY 2015 VL 7 IS 19 BP 10080 EP 10084 DI 10.1021/acsami.5b02189 PG 5 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA CI8XM UT WOS:000355055000003 PM 25945395 ER PT J AU Haefner, DP Burks, SD AF Haefner, David P. Burks, Stephen D. TI Finite sampling corrected 3D noise with confidence intervals SO APPLIED OPTICS LA English DT Article AB When evaluated with a spatially uniform irradiance, an imaging sensor exhibits both spatial and temporal variations, which can be described as a three-dimensional (3D) random process considered as noise. In the 1990s, NVESD engineers developed an approximation to the 3D power spectral density for noise in imaging systems known as 3D noise. The goal was to decompose the 3D noise process into spatial and temporal components identify potential sources of origin. To characterize a sensor in terms of its 3D noise values, a finite number of samples in each of the three dimensions (two spatial, one temporal) were performed. In this correspondence, we developed the full sampling corrected 3D noise measurement and the corresponding confidence bounds. The accuracy of these methods was demonstrated through Monte Carlo simulations. Both the sampling correction as well as the confidence intervals can be applied a posteriori to the classic 3D noise calculation. The Matlab functions associated with this work can be found on the Mathworks file exchange ["Finite sampling corrected 3D noise with confidence intervals," https://www.mathworks.com/matlabcentral/fileexchange/49657-finite-sampling-corrected-3d-noise-with-confidence-intervals.]. C1 [Haefner, David P.; Burks, Stephen D.] US Army, RDECOM, CERDEC, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. RP Haefner, DP (reprint author), US Army, RDECOM, CERDEC, Night Vis & Elect Sensors Directorate, 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA. EM oss@nvl.army.mil NR 11 TC 4 Z9 4 U1 0 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD MAY 20 PY 2015 VL 54 IS 15 BP 4907 EP 4915 DI 10.1364/AO.54.004907 PG 9 WC Optics SC Optics GA CI6UL UT WOS:000354898100039 PM 26192530 ER PT J AU Brunye, TT Collier, ZA Cantelon, J Holmes, A Wood, MD Linkov, I Taylor, HA AF Brunye, Tad T. Collier, Zachary A. Cantelon, Julie Holmes, Amanda Wood, Matthew D. Linkov, Igor Taylor, Holly A. TI Strategies for Selecting Routes through Real-World Environments: Relative Topography, Initial Route Straightness, and Cardinal Direction SO PLOS ONE LA English DT Article ID SELF-REPORT MEASURE; BEHAVIOR; CONSTRAINTS; NAVIGATION; CHOICES; MODELS; NORTH; AREAS AB Previous research has demonstrated that route planners use several reliable strategies for selecting between alternate routes. Strategies include selecting straight rather than winding routes leaving an origin, selecting generally south-rather than north-going routes, and selecting routes that avoid traversal of complex topography. The contribution of this paper is characterizing the relative influence and potential interactions of these strategies. We also examine whether individual differences would predict any strategy reliance. Results showed evidence for independent and additive influences of all three strategies, with a strong influence of topography and initial segment straightness, and relatively weak influence of cardinal direction. Additively, routes were also disproportionately selected when they traversed relatively flat regions, had relatively straight initial segments, and went generally south rather than north. Two individual differences, extraversion and sense of direction, predicted the extent of some effects. Under real-world conditions navigators indeed consider a route's initial straightness, cardinal direction, and topography, but these cues differ in relative influence and vary in their application across individuals. C1 [Brunye, Tad T.; Cantelon, Julie; Holmes, Amanda] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA. [Brunye, Tad T.; Cantelon, Julie; Holmes, Amanda] Tufts Univ, Dept Psychol, Medford, MA 02155 USA. [Collier, Zachary A.; Wood, Matthew D.; Linkov, Igor; Taylor, Holly A.] US Army Engineer Res & Dev Ctr, Vicksburg, MS USA. RP Brunye, TT (reprint author), US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA. EM thaddeus.t.brunye.civ@mail.mil FU U.S. Army Natick Soldier Research, Development, and Engineering Center (NSRDEC) [W911QY-13-C-0012]; U.S. Army Basic Research Program within the Geospatial Research and Engineering (GRE) Program of the U.S. Army Engineer Research & Development Center (ERDC) FX This work was funded by the U.S. Army Natick Soldier Research, Development, and Engineering Center (NSRDEC, Grant #W911QY-13-C-0012, PI: Holly A. Taylor), and the U.S. Army Basic Research Program within the Geospatial Research and Engineering (GRE) Program of the U.S. Army Engineer Research & Development Center (ERDC). Permission was granted by the U.S. Army Corps of Engineers, Chief of Engineers, and the U.S. Army Natick Soldier Research, Development, and Engineering Center, to publish this material. The views expressed in this article are solely those of the authors and do not reflect the official policies or positions of the Department of Army, the Department of Defense, or any other department or agency of the U.S. government. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 36 TC 1 Z9 1 U1 3 U2 7 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAY 20 PY 2015 VL 10 IS 5 AR e0124404 DI 10.1371/journal.pone.0124404 PG 16 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CI7CV UT WOS:000354921400017 PM 25992685 ER PT J AU Svoboda, M Brennan, JK Lisal, M AF Svoboda, Martin Brennan, John K. Lisal, Martin TI Molecular dynamics simulation of carbon dioxide in single-walled carbon nanotubes in the presence of water: structure and diffusion studies SO MOLECULAR PHYSICS LA English DT Article DE density profiles; carbon dioxide separation; water clustering; self-diffusion coefficients ID METAL-ORGANIC FRAMEWORKS; CO2 ADSORPTION; EQUILIBRIA; NITROGEN; SORPTION; MODEL; GAS AB We present a molecular dynamics study on the structure and diffusion of carbon dioxide in single-walled carbon nanotubes (SWCNTs) in the presence of water. We consider (10,10) and (15,15) SWCNTs of nanotube diameter 13.6 and 20.3 angstrom, respectively, with amounts of pre-adsorbed water equal to 0, 0.025, 0.1, and 0.2 g/cm(3). The density of the carbon dioxide in the SWCNTs corresponds to the maximum amount adsorbed at 300 K and 37.6 bar, as previously determined by grand canonical Monte Carlo simulation. We determine the structure of the confined fluids by calculating density distributions in the nanotube axial and radial directions, along with a second-order Legendre polynomial to elucidate their molecular orientations. The diffusion of the confined molecules is then analysed via both the overall time-dependent and space-dependent mean-square displacements in the nanotube axial direction. We find that the systems display distinct axial regions comprised of either pure carbon dioxide or water clusters that have been penetrated by CO2 molecules. The confined molecules form layered structures that strongly depend on the nanotube diameter. However for particular SWCNTs, the shape of the layered structures is not affected by the presence of pre-adsorbed water. The amount of pre-adsorbed water strongly influences the overall diffusion, while the space variation of fluid densities across the nanotubes has a relatively small effect on the space-dependent diffusion. C1 [Svoboda, Martin; Lisal, Martin] Inst Chem Proc Fundamentals ASCR, Lab Aerosols Chem & Phys, Prague, Czech Republic. [Svoboda, Martin; Lisal, Martin] Univ JE Purkyne, Inst Sci, Dept Phys, Usti Nad Labem, Czech Republic. [Brennan, John K.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen, MD USA. RP Lisal, M (reprint author), Inst Chem Proc Fundamentals ASCR, Lab Aerosols Chem & Phys, Prague, Czech Republic. EM lisal@icpf.cas.cz RI Svoboda, Martin/L-9724-2015; Lisal, Martin/A-8176-2011 OI Svoboda, Martin/0000-0002-8449-2078; Lisal, Martin/0000-0001-8005-7143 FU Czech Science Foundation [13-09914S]; Internal Grant Agency of J. E. Purkinje University [53222 15 0008 01] FX This work was supported by the Czech Science Foundation (project number 13-09914S); the Internal Grant Agency of J. E. Purkinje University (project number 53222 15 0008 01). NR 47 TC 2 Z9 2 U1 1 U2 31 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0026-8976 EI 1362-3028 J9 MOL PHYS JI Mol. Phys. PD MAY 19 PY 2015 VL 113 IS 9-10 SI SI BP 1124 EP 1136 DI 10.1080/00268976.2015.1005190 PG 13 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA CI5JA UT WOS:000354790400021 ER PT J AU Eller, MA Opollo, MS Liu, M Redd, AD Eller, LA Kityo, C Kayiwa, J Laeyendecker, O Wawer, MJ Milazzo, M Kiwanuka, N Gray, RH Serwadda, D Sewankambo, NK Quinn, TC Michael, NL Wabwire-Mangen, F Sandberg, JK Robb, ML AF Eller, Michael A. Opollo, Marc S. Liu, Michelle Redd, Andrew D. Eller, Leigh Anne Kityo, Cissy Kayiwa, Joshua Laeyendecker, Oliver Wawer, Maria J. Milazzo, Mark Kiwanuka, Noah Gray, Ronald H. Serwadda, David Sewankambo, Nelson K. Quinn, Thomas C. Michael, Nelson L. Wabwire-Mangen, Fred Sandberg, Johan K. Robb, Merlin L. TI HIV Type 1 Disease Progression to AIDS and Death in a Rural Ugandan Cohort Is Primarily Dependent on Viral Load Despite Variable Subtype and T-Cell Immune Activation Levels SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE HIV-1; AIDS; subtype D; immune activation; PD-1; viral load ID HUMAN-IMMUNODEFICIENCY-VIRUS; RECEIVING ANTIRETROVIRAL THERAPY; SEX-DIFFERENCES; RAKAI DISTRICT; RNA LEVELS; INFECTION; CD4(+); MORTALITY; BURDEN; AFRICA AB Methods.aEuro integral HIV-1 seroconverters (n = 156) from rural Uganda were evaluated to assess the effects of T-cell activation, viral load, and viral subtype on disease progression during clinical follow-up. Results.aEuro integral The frequency of activated T cells was increased in HIV-1-infected Ugandans, compared with community matched uninfected individuals, but did not differ significantly between viral subtypes. Higher HIV-1 load, subtype D, older age, and high T-cell activation levels were associated with faster disease progression to AIDS or death. In a multivariate Cox regression analysis, HIV-1 load was the strongest predictor of progression, with subtype also contributing. T-cell activation did not emerge an independent predictor of disease progression from this particular cohort. Conclusions.aEuro integral These findings suggest that the independent contribution of T-cell activation on morbidity and mortality observed in European and North American cohorts may not be directly translated to the HIV epidemic in East Africa. In this setting, HIV-1 load appears to be the primary determinant of disease progression. C1 [Eller, Michael A.; Liu, Michelle; Eller, Leigh Anne; Milazzo, Mark; Michael, Nelson L.; Robb, Merlin L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. [Eller, Michael A.; Liu, Michelle; Eller, Leigh Anne; Milazzo, Mark; Robb, Merlin L.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Redd, Andrew D.; Laeyendecker, Oliver; Quinn, Thomas C.] NIAID, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA. [Laeyendecker, Oliver; Quinn, Thomas C.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. [Wawer, Maria J.; Gray, Ronald H.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA. [Opollo, Marc S.; Wabwire-Mangen, Fred] Makerere Univ, Coll Hlth Sci, Makerere Univ Walter Reed Project, Kampala, Uganda. [Kityo, Cissy; Kayiwa, Joshua] Makerere Univ, Coll Hlth Sci, Joint Clin Res Ctr, Kampala, Uganda. [Kiwanuka, Noah; Serwadda, David; Wabwire-Mangen, Fred] Makerere Univ, Coll Hlth Sci, Sch Publ Hlth, Kampala, Uganda. [Sewankambo, Nelson K.] Makerere Univ, Coll Hlth Sci, Fac Med, Kampala, Uganda. [Kiwanuka, Noah; Serwadda, David; Sewankambo, Nelson K.] Uganda Virus Res Inst, Rakai Hlth Sci Program, Entebbe, Uganda. [Sandberg, Johan K.] Karolinska Inst, Dept Med, Karolinska Univ Hosp Huddinge, Ctr Infect Med, Stockholm, Sweden. RP Eller, MA (reprint author), Walter Reed Army Inst Res, HJF, US Mil HIV Res Program, 503 Robert Grant Ave,1N11, Silver Spring, MD 20910 USA. EM meller@hivresearch.org OI Sewankambo, Nelson/0000-0001-9362-053X; Laeyendecker, Oliver/0000-0002-6429-4760 FU Henry M. Jackson Foundation for the Advancement of Military Medicine [W81XWH-11-2-0174]; US Army Medical Research and Materiel Command [W81XWH-11-2-0174]; Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health FX This work was supported by a cooperative agreement (W81XWH-11-2-0174) between the Henry M. Jackson Foundation for the Advancement of Military Medicine and the US Army Medical Research and Materiel Command; and the Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health. NR 50 TC 3 Z9 3 U1 2 U2 3 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD MAY 15 PY 2015 VL 211 IS 10 BP 1574 EP 1584 DI 10.1093/infdis/jiu646 PG 11 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA CI4MG UT WOS:000354723000008 PM 25404522 ER PT J AU Meya, DB Okurut, S Zziwa, G Rolfes, MA Kelsey, M Cose, S Joloba, M Naluyima, P Palmer, BE Kambugu, A Mayanja-Kizza, H Bohjanen, PR Eller, MA Wahl, SM Boulware, DR Manabe, YC Janoff, EN AF Meya, David B. Okurut, Samuel Zziwa, Godfrey Rolfes, Melissa A. Kelsey, Melander Cose, Steve Joloba, Moses Naluyima, Prossy Palmer, Brent E. Kambugu, Andrew Mayanja-Kizza, Harriet Bohjanen, Paul R. Eller, Michael A. Wahl, Sharon M. Boulware, David R. Manabe, Yuka C. Janoff, Edward N. TI Cellular Immune Activation in Cerebrospinal Fluid From Ugandans With Cryptococcal Meningitis and Immune Reconstitution Inflammatory Syndrome SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE cryptococcal meningitis; cryptococcus; HIV; cerebrospinal fluid; immune responses; cell activation ID CENTRAL-NERVOUS-SYSTEM; CD4(+) T-CELLS; HIV-1-INFECTED PATIENTS; ANTIRETROVIRAL THERAPY; CLINICAL-FEATURES; INFECTED PATIENTS; HIV-INFECTION; NEOFORMANS; TUBERCULOSIS; MECHANISMS AB Methods.aEuro integral We characterized the lineage and activation status of mononuclear cells in blood and CSF of HIV-infected patients with noncryptococcal meningitis (NCM) (n = 10), those with CM at day 0 (n = 40) or day 14 (n = 21) of antifungal therapy, and those with CM-IRIS (n = 10). Results.aEuro integral At diagnosis, highly activated CD8(+) T cells predominated in CSF in both CM and NCM. CM-IRIS was associated with an increasing frequency of CSF CD4(+) T cells (increased from 2.2% to 23%; P = .06), a shift in monocyte phenotype from classic to an intermediate/proinflammatory, and increased programmed death ligand 1 expression on natural killer cells (increased from 11.9% to 61.6%, P = .03). CSF cellular responses were distinct from responses in peripheral blood. Conclusions.aEuro integral After CM, T cells in CSF tend to evolve with the development of IRIS, with increasing proportions of activated CD4(+) T cells, migration of intermediate monocytes to the CSF, and declining fungal burden. These changes provide insight into IRIS pathogenesis and could be exploited to more effectively treat CM and prevent CM-IRIS. C1 [Meya, David B.; Kambugu, Andrew; Manabe, Yuka C.] Makerere Univ, Coll Hlth Sci, Infect Dis Inst, Kampala, Uganda. [Meya, David B.; Cose, Steve; Mayanja-Kizza, Harriet] Makerere Univ, Coll Hlth Sci, Sch Med, Kampala, Uganda. [Joloba, Moses] Makerere Univ, Dept Microbiol, Sch Biomed Sci, Kampala, Uganda. [Okurut, Samuel; Zziwa, Godfrey] Makerere Univ Reed Project, Kampala, Uganda. [Cose, Steve] Uganda Virus Res Inst, Med Res Council, Uganda Res Unit AIDS, Entebbe, Uganda. [Meya, David B.; Rolfes, Melissa A.; Boulware, David R.] Univ Minnesota, Dept Med, Ctr Infect Dis & Microbiol Translat Res, Minneapolis, MN 55455 USA. [Kelsey, Melander; Janoff, Edward N.] Univ Colorado Denver, Mucosal & Vaccine Res Program Colorado, Aurora, CO USA. [Kelsey, Melander; Janoff, Edward N.] Denver Vet Affairs Med Ctr, Baltimore, MD USA. [Manabe, Yuka C.] Johns Hopkins Univ, Dept Med, Div Infect Dis, Baltimore, MD USA. [Eller, Michael A.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Eller, Michael A.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Wahl, Sharon M.] Natl Inst Dent & Craniofacial Res, NIH, Bethesda, MD USA. [Cose, Steve] London Sch Hyg & Trop Med, London, England. RP Meya, DB (reprint author), Makerere Univ, Coll Hlth Sci, Infect Dis Inst, POB 22418, Kampala, Uganda. EM david.meya@gmail.com OI Mayanja-Kizza, Harriet/0000-0002-9297-6208; Joloba, Moses/0000-0002-0334-9983; Boulware, David/0000-0002-4715-0060; Cose, Stephen/0000-0002-5156-037X FU National Institutes of Health [R01AI078934, U01AI089244, NS065713, R01AI108479, K24AI096925, T32AI055433, R21NS065713]; Wellcome Trust (Training Health Researchers into Vocational Excellence [THRiVE]) in East Africa [087540]; GlaxoSmithKline Collaborative Investigator Research Award; Veterans Affairs Research Service FX This work was supported by the National Institutes of Health (grants R01AI078934, U01AI089244, NS065713, R01AI108479, K24AI096925, T32AI055433, and R21NS065713); the Wellcome Trust (Training Health Researchers into Vocational Excellence [THRiVE]) in East Africa (grant 087540), the GlaxoSmithKline Collaborative Investigator Research Award, and the Veterans Affairs Research Service. NR 45 TC 8 Z9 8 U1 0 U2 4 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD MAY 15 PY 2015 VL 211 IS 10 BP 1597 EP 1606 DI 10.1093/infdis/jiu664 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA CI4MG UT WOS:000354723000010 PM 25492918 ER PT J AU King, MA Leon, LR Mustico, DL Haines, JM Clanton, TL AF King, Michelle A. Leon, Lisa R. Mustico, Danielle L. Haines, Joel M. Clanton, Thomas L. TI Biomarkers of multiorgan injury in a preclinical model of exertional heat stroke SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE exercise; liver injury; intestinal injury; hyperthermia; rhabdomyolysis ID INTESTINAL PERMEABILITY; THERMAL-STRESS; LIVER DAMAGE; BLOOD-FLOW; RAT MODEL; HEATSTROKE; EXERCISE; MICE; HYPERTHERMIA; SEPSIS AB It is likely that the pathophysiology of exertional heat stroke (EHS) differs from passive heat stroke (PHS), but this has been difficult to verify experimentally. C57B1/6 mice were instrumented with temperature transponders and underwent 3 wk of training using voluntary and forced running wheels. An EHS group was exposed to environmental temperatures (T-env) of 37.5, 38.5, or 39.5 degrees C at either 30, 50, or 90% relative humidities (RH) while exercising on a forced running wheel. Results were compared with sham-matched exercise controls (EXC) and naive controls (NC). In EHS, mice exercised in heat until they reached limiting neurological symptoms (loss of consciousness). The symptom-limited maximum core temperatures achieved were between 42.1 and 42.5 degrees C at 50% RH. All mice that were followed for 4 days survived. Additional groups were killed at 0.5, 3, 24, and 96 h, post-EHS or -EXC. Histopathology revealed extensive damage in all regions of the small intestine, liver, and kidney. Plasma creatine kinase, blood urea nitrogen, alanine transaminase, and intestinal fatty acid binding protein-2 were significantly elevated compared with matched EXC and NC, suggesting multiple organ injury to striated muscle, kidney, liver, and intestine, respectively. EHS mice were hypoglycemic immediately following EHS but exhibited sustained hyperglycemia through 4 days. The results demonstrate unique features of survivable EHS in the mouse that included loss of consciousness, extensive organ injury, and rhabdomyolysis. C1 [King, Michelle A.; Mustico, Danielle L.; Haines, Joel M.; Clanton, Thomas L.] Univ Florida, Coll Hlth & Human Performance, Dept Appl Physiol & Kinesiol, Gainesville, FL 32611 USA. [Leon, Lisa R.] US Army Res Inst Environm Med, Thermal & Mt Div, Natick, MA USA. RP Clanton, TL (reprint author), Univ Florida, Coll Hlth & Human Performance, Dept Appl Physiol & Kinesiol, 100 FLG,1864 Stadium Rd, Gainesville, FL 32611 USA. EM tclanton@hhp.ufl.edu FU U.S. Army Research Institute for Environmental Medicine FX This research was entirely supported by a contract from the U.S. Army Research Institute for Environmental Medicine with supplemental support from the BK and Betty Stevens Endowment (to T. Clanton). In conducting the research described in this report, the investigators adhered to the Guide for the Care and Use of Laboratory Animals as prepared by the Committee for the Update of the Guide for the Care and Use of laboratory Animals of the Institute for Laboratory Animal Research, National Research Council. The opinions or assertions contained herein are the private views of the author(s) and are not to be construed as official or as reflecting the views of the Army or the Department of Defense. Citations of commercial organizations and trade names in this report do not constitute an official Department of the Army endorsement or approval of the products or services of these organizations. NR 72 TC 2 Z9 2 U1 0 U2 3 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 EI 1522-1601 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD MAY 15 PY 2015 VL 118 IS 10 BP 1207 EP 1220 DI 10.1152/japplphysiol.01051.2014 PG 14 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA CI4CW UT WOS:000354695300005 PM 25814640 ER PT J AU Tsiligkaridis, T Sadler, BM Hero, AO AF Tsiligkaridis, Theodoros Sadler, Brian M. Hero, Alfred O., III TI On Decentralized Estimation With Active Queries SO IEEE TRANSACTIONS ON SIGNAL PROCESSING LA English DT Article DE Active stochastic search; asymptotic consistency; belief sharing; decentralized estimation; target localization ID 20 QUESTIONS; LOCALIZATION AB We consider the problem of decentralized 20 questions with noise for multiple players/agents under the minimum entropy criterion in the setting of stochastic search over a parameter space, with application to target localization. We propose decentralized extensions of the active query-based stochastic search strategy that combines elements from the 20 questions approach and social learning. We prove convergence to correct consensus on the value of the parameter. This framework provides a flexible and tractable mathematical model for decentralized parameter estimation systems based on active querying. We illustrate the effectiveness and robustness of the proposed decentralized collaborative 20 questions algorithm for random network topologies with information sharing. C1 [Tsiligkaridis, Theodoros; Hero, Alfred O., III] Univ Michigan, Dept Elect Engn & Comp Sci, Ann Arbor, MI 48109 USA. [Sadler, Brian M.] US Army Res Lab, Adelphi, MD 20783 USA. RP Tsiligkaridis, T (reprint author), MIT, Lincoln Lab, Lexington, MA 02421 USA. EM ttsili@ll.mit.edu; brian.m.sadler6.civ@mail.mil; hero@umich.edu FU ARO [W911NF-11-1-0391] FX The research reported in this paper was supported in part by ARO grant W911NF-11-1-0391. NR 18 TC 4 Z9 4 U1 1 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1053-587X EI 1941-0476 J9 IEEE T SIGNAL PROCES JI IEEE Trans. Signal Process. PD MAY 15 PY 2015 VL 63 IS 10 BP 2610 EP 2622 DI 10.1109/TSP.2015.2411223 PG 13 WC Engineering, Electrical & Electronic SC Engineering GA CG9KN UT WOS:000353634000014 ER PT J AU Sambanthamoorthy, K Hickman, M Pattabiraman, N Palys, T Wagar, EJ AF Sambanthamoorthy, Karthik Hickman, Mark Pattabiraman, Nagarajan Palys, Thomas Wagar, Eric J. TI Modulating Acinetobacter baumannii biofilm development with molecules containing 3,4,5-trimethoxy-N,N ',N '-trimethylbenzohydrazide moiety SO BIOORGANIC & MEDICINAL CHEMISTRY LETTERS LA English DT Article DE Biofilm; Antibacterial; Small molecules; Acinetobacter ID ANTIMICROBIAL PEPTIDE LL-37; BACTERIAL BIOFILMS; INFECTIONS; RESISTANCE; STRAINS; IDENTIFICATION; MENINGITIS; HOSPITALS; FEATURES; IMPACT AB In recent years, Acinetobacter baumannii has emerged as a major cause of nosocomial infections, including infections of implanted medical devices. The treatment of infections caused by A. baumannii has been severely hampered due to their frequent resistance to currently available antibiotics, and most importantly the ability of A. baumannii to form biofilms, which plays a significant role in both persistence and antibiotic resistance. The inherent resistance of A. baumannii biofilms to host defenses and antimicrobial agents necessitates the search for novel approaches to deter biofilm formation. Here, we report our findings on nine compounds identified from structure-activity relationship (SAR) studies on an antibiofilm compound LP3134 that was reported earlier by Biofouling 2014, 30, 17. Compounds were evaluated for antibiofilm and anti-adherence activities against A. baumannii. The ability of the compounds to prevent biofilm development on urinary catheters was studied. Growth curve experiments indicated that compounds did not affect the planktonic growth of A. baumannii. All compounds inhibited A. baumannii biofilm development as well as impacting early adhesion on abiotic surfaces. Seven compounds were able to deter biofilm development on silicone catheters. Due to the continued rise of emerging multidrug-resistant A. baumannii, results from this study provide foundation for further development of these molecules to treat A. baumannii infections in wounds and medical devices. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Sambanthamoorthy, Karthik; Palys, Thomas; Wagar, Eric J.] Walter Reed Army Inst Res, Wound Infect, Bacterial Dis Branch, Silver Spring, MD 20910 USA. [Hickman, Mark] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. [Pattabiraman, Nagarajan] Molbox, Silver Spring, MD 20910 USA. RP Sambanthamoorthy, K (reprint author), Walter Reed Army Inst Res, Wound Infect, Bacterial Dis Branch, Silver Spring, MD 20910 USA. EM skarthik78in@gmail.com FU Military Infectious Diseases Research Program (MIDRP) [W0066_12_WR] FX The findings and opinions expressed herein belong to the authors and do not necessarily reflect the official views of the WRAIR, the U.S. Army, or the Department of Defense. This work was supported by Military Infectious Diseases Research Program (MIDRP) grant W0066_12_WR. NR 28 TC 1 Z9 1 U1 2 U2 13 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0960-894X EI 1464-3405 J9 BIOORG MED CHEM LETT JI Bioorg. Med. Chem. Lett. PD MAY 15 PY 2015 VL 25 IS 10 BP 2238 EP 2242 DI 10.1016/j.bmcl.2015.03.005 PG 5 WC Chemistry, Medicinal; Chemistry, Organic SC Pharmacology & Pharmacy; Chemistry GA CG7ZL UT WOS:000353526300041 PM 25881818 ER PT J AU Gardea, F Glaz, B Riddick, J Lagoudas, DC Naraghi, M AF Gardea, Frank Glaz, Bryan Riddick, Jaret Lagoudas, Dimitris C. Naraghi, Mohammad TI Energy Dissipation Due to Interfacial Slip in Nanocomposites Reinforced with Aligned Carbon Nanotubes SO ACS APPLIED MATERIALS & INTERFACES LA English DT Article DE interfacial slip; damping; slip-stick; mechanical interlocking ID SHEAR-LAG MODEL; POLYMER COMPOSITES; MECHANICAL-PROPERTIES AB Interfacial slip mechanisms of strain energy dissipation and vibration damping of highly aligned carbon nanotube (CNT) reinforced polymer composites were studied through experimentation and complementary micromechanics modeling. Experimentally, we have developed CNT-polystyrene (PS) composites with a high degree of CNT alignment via a combination of twin-screw extrusion and hot-drawing. The aligned nanocomposites enabled a focused study of the interfacial slip mechanics associated with shear stress concentrations along the CNT-PS interface induced by the elastic mismatch between the filler and matrix. The variation of storage and loss modulus suggests the initiation of the interfacial slip occurs at axial strains as low as 0.028%, primarily due to shear stress concentration along the CNT-PS interface. Through micromechanics modeling and by matching the model with the experimental results at the onset of slip, the interfacial shear strength was evaluated. The model was then used to provide additional insight into the experimental observations by showing that the nonlinear variation of damping with dynamic strain can be attributed to slip-stick behavior. The dependence of the interfacial load-transfer reversibility on the dynamic strain history and characteristic time scale was experimentally investigated to demonstrate the relative contribution of van der Waals (vdW) interactions, mechanical interlocking, and covalent bonding to shear interactions. C1 [Gardea, Frank; Lagoudas, Dimitris C.; Naraghi, Mohammad] Texas A&M Univ, Dept Aerosp Engn, College Stn, TX 77843 USA. [Glaz, Bryan; Riddick, Jaret] US Army Res Lab, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Naraghi, M (reprint author), Texas A&M Univ, Dept Aerosp Engn, 3409 TAMU, College Stn, TX 77843 USA. EM naraghi@aero.tamu.edu FU DOD - Army Research Laboratory [W911NF-14-2-0080] FX Use of the TAMU Materials Characterization Facility is acknowledged. M.N. and D.C.L. would like to acknowledge the support of DOD - Army Research Laboratory, under the award No. W911NF-14-2-0080. NR 34 TC 7 Z9 7 U1 3 U2 27 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1944-8244 J9 ACS APPL MATER INTER JI ACS Appl. Mater. Interfaces PD MAY 13 PY 2015 VL 7 IS 18 BP 9725 EP 9735 DI 10.1021/acsami.5b01459 PG 11 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA CI6XC UT WOS:000354906500047 PM 25905718 ER PT J AU Piekiel, NW Morris, CJ AF Piekiel, Nicholas W. Morris, Christopher J. TI Small-Scale, Self-Propagating Combustion Realized with On-Chip Porous Silicon SO ACS APPLIED MATERIALS & INTERFACES LA English DT Article DE microscale combustion; porous silicon; on-chip; energetic materials ID SOLID-PROPELLANT MICROTHRUSTER; NANOENERGETIC MATERIALS; MICROSTRUCTURE; FILMS; CRYSTALLIZATION; MICROCHANNELS; TECHNOLOGY; NANOSCALE; FOILS AB For small-scale energy applications, energetic materials represent a high energy density source that, in certain cases, can be accessed with a very small amount of energy input. Recent advances in microprocessing techniques allow for the implementation of a porous silicon energetic material onto a crystalline silicon wafer at the microscale; however, combustion at a small length scale remains to be fully investigated, particularly with regards to the limitations of increased relative heat loss during combustion. The present study explores the critical dimensions of an on-chip porous silicon energetic material (porous silicon + sodium perchlorate (NaClO4)) requited to propagate combustion. We etched similar to 97 mu m wide and similar to 45 mu m deep porous silicon channels that burned at a steady rate of 4.6 m/s, remaining steady across 90 degrees changes in direction. In an effort to minimize the potential on-chip footprint for energetic porous silicon, we also explored the minimum spacing between porous silicon channels. We demonstrated independent burning of porous silicon channels at a spacing of <40 mu m. Using this spacing, it was possible to have a flame path length of >0.5 m on a chip surface area of 1.65 cm(2). Smaller porous silicon channels of similar to 28 mu m wide and similar to 14 mu m deep were also utilized. These samples propagated combustion, but at times, did so unsteadily. This result may suggest that we are approaching a critical length scale for self-propagating combustion in a porous silicon energetic material. C1 [Piekiel, Nicholas W.; Morris, Christopher J.] US Army Res Lab, Adelphi, MD 20783 USA. RP Piekiel, NW (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM nicholas.piekiel.civ@mail.mil NR 48 TC 3 Z9 3 U1 1 U2 24 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1944-8244 J9 ACS APPL MATER INTER JI ACS Appl. Mater. Interfaces PD MAY 13 PY 2015 VL 7 IS 18 BP 9889 EP 9897 DI 10.1021/acsami.5b01964 PG 9 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA CI6XC UT WOS:000354906500066 PM 25898206 ER PT J AU Zimmermann, L Moser, A Grenell, A Dickerson, K Yao, QW Gerhardstein, P Barr, R AF Zimmermann, Laura Moser, Alecia Grenell, Amanda Dickerson, Kelly Yao, Qianwen Gerhardstein, Peter Barr, Rachel TI Do semantic contextual cues facilitate transfer learning from vidwo in toddlers? SO FRONTIERS IN PSYCHOLOGY LA English DT Article DE transfer deficit; context learning; imitation; social learning; learning from screen media; memory binding ID AGE-RELATED-CHANGES; VISUAL OBJECT RECOGNITION; LONG-TERM-MEMORY; DEFERRED IMITATION; PICTURE BOOKS; DEVELOPMENTAL-CHANGES; RELATIONAL MEMORY; EARLY-CHILDHOOD; TOUCH SCREEN; TOOL USE AB Young children typically demonstrate a transfer deficit, learning less from video than live presentations. Semantically meaningful context has been demonstrated to enhance learning in young children. We examined the effect of a semantically meaningful context on toddlers imitation performance. Two- and 2.5-year-olds participated in a puzzle imitation task to examine learning from either a live or televised model. The model demonstrated how to assemble a three-piece puzzle to make a fish or a boat, with the puzzle demonstration occurring against a semantically meaningful background context (ocean) or a yellow background (no context). Participants in the video condition performed significantly worse than participants in the live condition, demonstrating the typical transfer deficit effect. While the context helped improve overall levels of imitation, especially for the boat puzzle, only individual differences in the ability to self-generate a stimulus label were associated with a reduction in the transfer deficit. C1 [Zimmermann, Laura; Yao, Qianwen; Barr, Rachel] Georgetown Univ, Dept Psychol, Washington, DC 20057 USA. [Moser, Alecia; Gerhardstein, Peter] SUNY Binghamton, Dept Psychol, Binghamton, NY 13902 USA. [Grenell, Amanda] Univ Minnesota, Inst Child Dev, Minneapolis, MN 55455 USA. [Dickerson, Kelly] Army Res Lab, Human Res & Engn Directorate, Aberdeen, MD USA. RP Gerhardstein, P (reprint author), SUNY Binghamton, Dept Psychol, Binghamton, NY 13902 USA. EM gerhard@binghamton.edu FU NSF [1023772] FX Special thanks to the families and children who made this research possible. This research was supported by an NSF Grant to PG and RB (1023772). NR 70 TC 2 Z9 2 U1 3 U2 8 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND SN 1664-1078 J9 FRONT PSYCHOL JI Front. Psychol. PD MAY 12 PY 2015 VL 6 AR 561 DI 10.3389/fpsyg.2015.00561 PG 12 WC Psychology, Multidisciplinary SC Psychology GA CJ4DR UT WOS:000355435300001 PM 26029131 ER PT J AU Hakre, S Mydlarz, DG Dawson, P Danaher, PJ Gould, PL Witkop, CT Michael, NL Peel, SA Scott, PT Okulicz, JF AF Hakre, Shilpa Mydlarz, Dariusz G. Dawson, Peter Danaher, Patrick J. Gould, Philip L. Witkop, Catherine T. Michael, Nelson L. Peel, Sheila A. Scott, Paul T. Okulicz, Jason F. TI Epidemiology of HIV among US Air Force Military Personnel, 1996-2011 SO PLOS ONE LA English DT Article ID UNITED-STATES; INFECTION; AFGHANISTAN; MOBILITY; AFRICA; TRENDS; IMPACT; ARMY; IRAQ; CARE AB Objective The objectives of this study were to describe the epidemiology of HIV in the United States Air Force (USAF) from 1996 through 2011 and to assess whether socio-demographic characteristics and service-related mobility, including military deployments, were associated with HIV infection. Methods We conducted a retrospective cohort analysis of USAF personnel who were HIV-infected during the study period January 1, 1996 through December 31, 2011 and a matched case-control study. Cases were USAF personnel newly-diagnosed with HIV during the study period. Five randomly-selected HIV-uninfected controls were matched to each case by age, length of service, sex, race, service, component, and HIV test collection date. Socio-demographic and service-related mobility factors and HIV diagnosis were assessed using conditional logistic regression. Results During the study period, the USAF had 541 newly diagnosed HIV-infected cases. HIV incidence rate (per 100,000 person-years) among 473 active duty members was highest in 2007 (16.78), among black/African-American USAF members (26.60) and those aged 25 to 29 years (10.84). In unadjusted analysis restricted to personnel on active duty, 10 characteristics were identified and considered for final multivariate analysis. Of these single (adjusted odds ratio [aOR], 8.15, 95% confidence interval [CI] 5.71-11.6) or other marital status (aOR 4.60, 95% CI 2.72-7.75), communications/intelligence (aOR 2.57, 95% CI 1.84-3.60) or healthcare (aOR 2.07, 95% CI 1.28-3.35) occupations, and having no deployment in the past 2 years before diagnosis (aOR 2.02, 95% CI 1.47-2.78) conferred higher odds of HIV infection in adjusted analysis. Conclusion The highest risk of HIV infection in the USAF was among young unmarried deployment-naive males, especially those in higher risk occupation groups. In an era when worldwide military operations have increased, these analyses identified potential areas where targeted HIV prevention efforts may be beneficial in reducing HIV incidence in the USAF military population. C1 [Hakre, Shilpa] Henry M Jackson Fdn Adv Mil Med, United States Mil HIV Res Program, Bethesda, MD 20817 USA. [Mydlarz, Dariusz G.] Natl Guard Bur, Prevent & Occupat Med Branch, Arlington, VA USA. [Dawson, Peter] EMMES Corp, Biostat, Rockville, MD USA. [Danaher, Patrick J.; Okulicz, Jason F.] San Antonio Mil Med Ctr, Infect Dis Serv, San Antonio, TX USA. [Gould, Philip L.; Witkop, Catherine T.] Air Force Med Support Agcy, Def Hlth Headquarters, Falls Church, VA USA. [Michael, Nelson L.; Scott, Paul T.] Walter Reed Army Inst Res, United States Mil HIV Res Program, Bethesda, MD USA. [Peel, Sheila A.] Walter Reed Army Inst Res, United States Mil HIV Res Program, HIV Diagnost & Reference Lab, Silver Spring, MD USA. RP Hakre, S (reprint author), Henry M Jackson Fdn Adv Mil Med, United States Mil HIV Res Program, Bethesda, MD 20817 USA. EM shakre@hivresearch.org FU Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (HJF) [W81XWH-07-2-0067]; U.S. Department of Defense (DoD) [W81XWH-07-2-0067]; HJF FX This work was supported by a cooperative agreement (W81XWH-07-2-0067) between The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (HJF), and the U.S. Department of Defense (DoD). The views expressed are those of the authors and should not be construed to represent the positions of the DoD. Co-author Peter Dawson is employed by Biostatistics, The EMMES Corporation. The HJF contracted the EMMES Corporation to provide data management and analysis support for this body of work; this contract was funded by the cooperative agreement between HJF and the DoD. The EMMES Corporation provided support in the form of salary for author PD, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific role of this author is articulated in the 'author contributions' section. NR 34 TC 1 Z9 1 U1 0 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAY 11 PY 2015 VL 10 IS 5 AR e0126700 DI 10.1371/journal.pone.0126700 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CI1YY UT WOS:000354542500137 PM 25961564 ER PT J AU Valverde, S Ohse, S Turalska, M West, BJ Garcia-Ojalvo, J AF Valverde, Sergi Ohse, Sebastian Turalska, Malgorzata West, Bruce J. Garcia-Ojalvo, Jordi TI Structural determinants of criticality in biological networks SO FRONTIERS IN PHYSIOLOGY LA English DT Review DE criticality; power laws; hierarchical modular networks; neural networks; gene regulatory networks; evolution; robustness ID RANDOM BOOLEAN NETWORKS; GENETIC REGULATORY NETWORKS; SELF-ORGANIZED CRITICALITY; NEURONAL AVALANCHES; SMALL-WORLD; BRAIN NETWORKS; FUNCTIONAL CONNECTIVITY; DYNAMICS; STATE; TOPOLOGY AB Many adaptive evolutionary systems display spatial and temporal features, such as long-range correlations, typically associated with the critical point of a phase transition in statistical physics. Empirical and theoretical studies suggest that operating near criticality enhances the functionality of biological networks, such as brain and gene networks, in terms for instance of information processing, robustness, and evolvability. While previous studies have explained criticality with specific system features, we still lack a general theory of critical behavior in biological systems. Here we look at this problem from the complex systems perspective, since in principle all critical biological circuits have in common the fact that their internal organization can be described as a complex network. An important question is how self-similar structure influences self-similar dynamics. Modularity and heterogeneity, for instance, affect the location of critical points and can be used to tune the system toward criticality. We review and discuss recent studies on the criticality of neuronal and genetic networks, and discuss the implications of network theory when assessing the evolutionary features of criticality. C1 [Valverde, Sergi] Univ Pompeu Fabra, ICREA Complex Syst Lab, Barcelona 08003, Spain. [Valverde, Sergi] Univ Pompeu Fabra, CSIC, Inst Evolutionary Biol, Barcelona 08003, Spain. [Ohse, Sebastian] Univ Freiburg, Inst Mol Med & Cell Res, D-79106 Freiburg, Germany. [Turalska, Malgorzata; West, Bruce J.] Duke Univ, Dept Phys, Durham, NC 27706 USA. [West, Bruce J.] US Army, Res Off, Math & Informat Sci Directorate, Res Triangle Pk, NC 27709 USA. [Garcia-Ojalvo, Jordi] Univ Pompeu Fabra, Dept Expt & Hlth Sci, Barcelona 08003, Spain. RP Valverde, S (reprint author), Univ Pompeu Fabra, ICREA Complex Syst Lab, Dr Aiguader 88, Barcelona 08003, Spain. EM sergi.valverde@upf.edu OI Garcia-Ojalvo, Jordi/0000-0002-3716-7520 FU Spanish Ministry of Economy and Competitiveness [FIS2013-44674-P, FIS2012-37655-C02-01]; FEDER; ICREA Academia programme; Army Research Office [W911NF-04-D-0001] FX This paper was supported by the Spanish Ministry of Economy and Competitiveness (Grants FIS2013-44674-P and FIS2012-37655-C02-01) and FEDER and by the ICREA Academia programme (JGO). MT acknowledges support of the Army Research Office through grant W911NF-04-D-0001. NR 74 TC 5 Z9 5 U1 4 U2 16 PU FRONTIERS MEDIA SA PI LAUSANNE PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLAND SN 1664-042X J9 FRONT PHYSIOL JI Front. Physiol. PD MAY 8 PY 2015 VL 6 AR 127 DI 10.3389/fphys.2015.00127 PG 9 WC Physiology SC Physiology GA CM3NA UT WOS:000357587900001 PM 26005422 ER PT J AU Christie, A Davies-Wayne, GJ Cordier-Lasalle, T Blackley, DJ Laney, AS Williams, DE Shinde, SA Badio, M Lo, T Mate, SE Ladner, JT Wiley, MR Kugelman, JR Palacios, G Holbrook, MR Janosko, KB de Wit, E van Doremalen, N Munster, VJ Pettitt, J Schoepp, RJ Verhenne, L Evlampidou, I Kollie, KK Sieh, SB Gasasira, A Bolay, F Kateh, FN Nyenswah, TG De Cock, KM AF Christie, Athalia Davies-Wayne, Gloria J. Cordier-Lasalle, Thierry Blackley, David J. Laney, A. Scott Williams, Desmond E. Shinde, Shivam A. Badio, Moses Lo, Terrence Mate, Suzanne E. Ladner, Jason T. Wiley, Michael R. Kugelman, Jeffrey R. Palacios, Gustavo Holbrook, Michael R. Janosko, Krisztina B. de Wit, Emmie van Doremalen, Neeltje Munster, Vincent J. Pettitt, James Schoepp, Randal J. Verhenne, Leen Evlampidou, Iro Kollie, Karsor K. Sieh, Sonpon B. Gasasira, Alex Bolay, Fatorma Kateh, Francis N. Nyenswah, Tolbert G. De Cock, Kevin M. TI Possible Sexual Transmission of Ebola Virus - Liberia, 2015 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID OUTBREAK; KIKWIT; CONGO C1 [Christie, Athalia; Blackley, David J.; Laney, A. Scott; Williams, Desmond E.; Lo, Terrence; De Cock, Kevin M.] CDC, Atlanta, GA 30333 USA. [Davies-Wayne, Gloria J.; Cordier-Lasalle, Thierry; Shinde, Shivam A.; Gasasira, Alex] World Hlth Org, Geneva, Switzerland. [Badio, Moses; Kollie, Karsor K.; Sieh, Sonpon B.; Kateh, Francis N.; Nyenswah, Tolbert G.] Minist Hlth & Social Welf, Monrovia, Liberia. [Mate, Suzanne E.; Ladner, Jason T.; Wiley, Michael R.; Kugelman, Jeffrey R.; Palacios, Gustavo; Schoepp, Randal J.] US Army Med Res Inst Infect Dis, Ft Detrick, MD USA. [Holbrook, Michael R.; Janosko, Krisztina B.; de Wit, Emmie; van Doremalen, Neeltje; Munster, Vincent J.; Pettitt, James] NIH, Bethesda, MD USA. [Verhenne, Leen; Evlampidou, Iro] Med Sans Frontieres, Paris, France. [Bolay, Fatorma] Liberian Inst Biomed Res, Monrovia, Liberia. RP Christie, A (reprint author), CDC, Atlanta, GA 30333 USA. EM akc9@cdc.gov RI Palacios, Gustavo/I-7773-2015; OI Palacios, Gustavo/0000-0001-5062-1938; de Wit, Emmie/0000-0002-9763-7758; Munster, Vincent/0000-0002-2288-3196 NR 9 TC 56 Z9 58 U1 0 U2 30 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD MAY 8 PY 2015 VL 64 IS 17 BP 479 EP 481 PG 3 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CI2RP UT WOS:000354595000006 PM 25950255 ER PT J AU Ciraci, C Scalora, M Smith, DR AF Ciraci, Cristian Scalora, Michael Smith, David R. TI Third-harmonic generation in the presence of classical nonlocal effects in gap-plasmon nanostructures SO PHYSICAL REVIEW B LA English DT Article ID MAGNETIC METAMATERIALS; METAL-SURFACES; OPTICAL NONLINEARITY; HARMONIC-GENERATION; ENHANCEMENT; NANOPARTICLES; CLUSTERS; SILVER AB Classical nonlocality in conducting nanostructures has been shown to dramatically alter the linear optical response by placing a fundamental limit on the maximum field enhancement that can be achieved. This limit directly extends to all nonlinear processes, which depend on field amplitudes. A numerical study of third-harmonic generation in metal film-coupled nanowires reveals that for subnanometer vacuum gaps, the nonlocality may boost the effective nonlinearity by 5 orders of magnitude as the field penetrates deeper inside the metal than that predicted assuming a purely local electronic response. We also study the impact of a nonlinear dielectric placed in the gap region. In this case the effect of nonlocality could be masked by the third-harmonic signal generated by the spacer. By etching the dielectric underneath the nanowire, however, it is possible to muffle such contributions. Calculations are performed for both silver and gold nanowire. C1 [Ciraci, Cristian] Ctr Biomol Nanotechnol, Ist Italiano Tecnol, I-73010 Arnesano, Italy. [Scalora, Michael] US Army, RDECOM, CM Bowden Res Facil, Redstone Arsenal, AL 35803 USA. [Smith, David R.] Duke Univ, Ctr Metamat & Integrated Plasmon, Durham, NC 27708 USA. [Smith, David R.] Duke Univ, Dept Elect & Comp Engn, Durham, NC 27708 USA. RP Ciraci, C (reprint author), Ctr Biomol Nanotechnol, Ist Italiano Tecnol, Via Barsanti, I-73010 Arnesano, Italy. EM cristian.ciraci@iit.it RI Smith, David/E-4710-2012 FU Air Force Office of Scientific Research (AFOSR) [FA9550-12-1-0491]; Army Research Office through a Multidisciplinary University Research Initiative [W911NF-09-1-0539] FX We thank D. de Ceglia, M. A. Vincenti, and J. W. Haus for helpful input and discussion. This work was supported by the Air Force Office of Scientific Research (AFOSR), Grant No. FA9550-12-1-0491 and by the Army Research Office through a Multidisciplinary University Research Initiative (Grant No. W911NF-09-1-0539). NR 43 TC 8 Z9 8 U1 2 U2 38 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2469-9950 EI 2469-9969 J9 PHYS REV B JI Phys. Rev. B PD MAY 8 PY 2015 VL 91 IS 20 AR 205403 DI 10.1103/PhysRevB.91.205403 PG 7 WC Physics, Condensed Matter SC Physics GA CH7XO UT WOS:000354250100005 ER PT J AU Rudin, S Rupper, G Shur, M AF Rudin, Sergey Rupper, Greg Shur, Michael TI Ultimate response time of high electron mobility transistors SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID FIELD-EFFECT TRANSISTORS; TERAHERTZ RADIATION; RESONANT DETECTION; DETECTORS; CMOS AB We present theoretical studies of the response time of the two-dimensional gated electron gas to femtosecond pulses. Our hydrodynamic simulations show that the device response to a short pulse or a step-function signal is either smooth or oscillating time-decay at low and high mobility, mu, values, respectively. At small gate voltage swings, U-0 = U-g - U-th, where U-g is the gate voltage and Uth is the threshold voltage, such that mu U-0/L< v(s), where L is the channel length and vs is the effective electron saturation velocity, the decay time in the low mobility samples is on the order of L-2/(mu U-0), in agreement with the analytical drift model. However, the decay is preceded by a delay time on the order of L/s, where s is the plasma wave velocity. This delay is the ballistic transport signature in collision-dominated devices, which becomes important during very short time periods. In the high mobility devices, the period of the decaying oscillations is on the order of the plasma wave velocity transit time. Our analysis shows that short channel field effect transistors operating in the plasmonic regime can meet the requirements for applications as terahertz detectors, mixers, delay lines, and phase shifters in ultra high-speed wireless communication circuits. (C) 2015 AIP Publishing LLC. C1 [Rudin, Sergey; Rupper, Greg] US Army Res Lab, Adelphi, MD 20783 USA. [Shur, Michael] Rensselaer Polytech Inst, Troy, NY 12180 USA. RP Rudin, S (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. RI Shur, Michael/A-4374-2016 OI Shur, Michael/0000-0003-0976-6232 FU U.S. Army Research Laboratory through the Collaborative Research Alliance (CRA) for Multi-Scale Modeling of Electronic materials (MSME) FX The work at RPI (M. Shur) was supported in part by the U.S. Army Research Laboratory through the Collaborative Research Alliance (CRA) for Multi-Scale Modeling of Electronic materials (MSME). NR 31 TC 6 Z9 6 U1 4 U2 10 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD MAY 7 PY 2015 VL 117 IS 17 AR 174502 DI 10.1063/1.4919706 PG 5 WC Physics, Applied SC Physics GA CI7YW UT WOS:000354984100599 ER PT J AU Singamaneni, SR Prater, JT Nori, S Kumar, D Lee, B Misra, V Narayan, J AF Singamaneni, Srinivasa Rao Prater, J. T. Nori, S. Kumar, D. Lee, Bongmook Misra, V. Narayan, J. TI Ferroelectric and magnetic properties of multiferroic BiFeO3-La0.7Sr0.3MnO3 heterostructures integrated with Si (100) SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID THIN-FILMS; BIFEO3 AB We report on the electrical, ferroelectric, and magnetic properties of BiFeO3 (BFO)-La0.7Sr0.3MnO3 heterostructures deposited epitaxially onto Si(100) substrates. Temperature dependent (200-350 K) current-voltage (I-V), switching spectroscopy piezo-response force microscopy (SSPFM), and temperature dependent (5-300 K) anisotropic magnetization measurements have been performed. The BFO (100-nm thick)-based device structures were fabricated with a 250nm thick La0.7Sr0.3MnO3 bottom electrode and 200 mu m circular top Pt electrodes. I-V measurements performed at various temperatures indicated that the devices retained their as-deposited characteristics and exhibited non-leaky behavior up to at least 50 cycles. The temperature-dependent measurements showed clear diode-like behavior and resistive (hysteretic) switching behaviour. Characteristic butterfly loops (of several cycles) were observed in the PFM amplitude signals of the BFO film. In addition, the phase signal indicated a clear (180 degrees) switching behavior at the switching voltage of 4-5V, providing unambiguous evidence for the occurrence of ferroelectricity in BFO films integrated on Si (100). The temperature-and angle-dependent zero field cooled isothermal (5 K) magnetization measurements were consistent with the presence of uniaxial magnetic anisotropy. This work makes an important step for the fabrication of CMOS-compatible BFO devices for memory applications. (C) 2015 AIP Publishing LLC. C1 [Singamaneni, Srinivasa Rao; Prater, J. T.] Army Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA. [Singamaneni, Srinivasa Rao; Prater, J. T.; Nori, S.; Narayan, J.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Kumar, D.] North Carolina A&T Univ, Ctr Adv Mat & Smart Struct, Greensboro, NC 27411 USA. [Lee, Bongmook; Misra, V.] N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. RP Singamaneni, SR (reprint author), Army Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA. EM ssingam@ncsu.edu RI Nori, Sudhakar/E-8111-2010 FU National Academy of Science (NAS), U.S.; Army Research Office [W911NF-04-D-0003] FX S.R.S acknowledges National Academy of Science (NAS), U.S. for awarding the NRC postdoctoral research associate fellowship. The authors are pleased to acknowledge the support of the Army Research Office under Grant No. W911NF-04-D-0003. Also, the authors acknowledge the use of the Analytical Instrumentation Facility (AIF) at North Carolina State University, which is supported by the State of North Carolina and the National Science Foundation. NR 17 TC 4 Z9 4 U1 3 U2 36 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD MAY 7 PY 2015 VL 117 IS 17 AR 17D908 DI 10.1063/1.4913811 PG 4 WC Physics, Applied SC Physics GA CI7YW UT WOS:000354984100438 ER PT J AU Singamaneni, SR Fan, W Prater, JT Narayan, J AF Singamaneni, Srinivasa Rao Fan, Wu Prater, J. T. Narayan, J. TI Complete vertical M-H loop shift in La0.7Sr0.3MnO3/SrRuO3 thin film heterostructures SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID POSITIVE EXCHANGE-BIAS; OXIDE INTERFACES; SUPERLATTICES; BILAYERS; SRRUO3 AB In the current work, we have epitaxially integrated La0.7Sr0.3MnO3/SrRuO3 (LSMO/SRO) BLs with the technologically important substrate Si (100) using pulsed laser deposition. Interestingly, at 4K, under the magnetic field sweep of +/- 1500 Oe, a complete vertical M-H loop shift is observed in the sample prepared with 180 nm SRO thickness, which is unusual. This vertical shift persists even up to a field sweep range of +/- 6000 Oe, at which point the shift disappears and a symmetrical hysteresis loop centered at the origin is observed. In contrast, at the same temperature, under the same field sweep range, we observe a normal M-H loop (no or little vertical shift) from the sample with 45 nm SRO thickness. In both the cases, the LSMO thickness was held constant at similar to 100 nm. It appears that SRO moment is frozen in place in the latter case, providing a clear demonstration of the effect that biasing layer (SRO) thickness can have on the magnetic characteristics of bilayer films. We attribute this vertical shift to the strong interplay between the uniaxial magnetocrystalline anisotropy and microscopic interface domain structure. (c) 2015 AIP Publishing LLC. C1 [Singamaneni, Srinivasa Rao; Prater, J. T.] Army Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA. [Singamaneni, Srinivasa Rao; Fan, Wu; Prater, J. T.; Narayan, J.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. RP Singamaneni, SR (reprint author), Army Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA. EM ssingam@ncsu.edu FU National Academy of Science (NAS), USA; Army Research Office [W911NF-04-D-0003] FX S.R.S. acknowledges National Academy of Science (NAS), USA for awarding the NRC postdoctoral research associate fellowship. The authors are pleased to acknowledge the support of the Army Research Office under Grant No. W911NF-04-D-0003. NR 26 TC 4 Z9 4 U1 4 U2 47 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD MAY 7 PY 2015 VL 117 IS 17 AR 17B711 DI 10.1063/1.4913630 PG 4 WC Physics, Applied SC Physics GA CI7YW UT WOS:000354984100191 ER PT J AU Phanuphak, N Teeratakulpisarn, N van Griensven, F Chomchey, N Pinyakorn, S Fletcher, JLK Trichavaroj, R Pattanachaiwit, S Michael, N Phanuphak, P Kim, JH Ananworanich, J AF Phanuphak, Nittaya Teeratakulpisarn, Nipat van Griensven, Frits Chomchey, Nitiya Pinyakorn, Suteeraporn Fletcher, James L. K. Trichavaroj, Rapee Pattanachaiwit, Supanit Michael, Nelson Phanuphak, Praphan Kim, Jerome H. Ananworanich, Jintanat CA RV254 SEARCH Study Grp TI Anogenital HIV RNA in Thai men who have sex with men in Bangkok during acute HIV infection and after randomization to standard vs. intensified antiretroviral regimens SO JOURNAL OF THE INTERNATIONAL AIDS SOCIETY LA English DT Article DE acute HIV; MSM; anogenital; HIV RNA; antiretroviral therapy; Asia ID MALE GENITAL-TRACT; IMMUNODEFICIENCY-VIRUS TYPE-1; SEMINAL PLASMA; VIRAL LOAD; HIV-1-INFECTED MEN; TRANSMISSION; THERAPY; SEMEN; DYNAMICS; PHARMACOKINETICS AB Introduction: HIV transmission risk is highest during acute HIV infection (AHI). We evaluated HIV RNA in the anogenital compartment in men who have sex with men (MSM) during AHI and compared time to undetectable HIV RNA after three-drug versus five-drug antiretroviral therapy (ART) to understand risk for onward HIV transmission. Methods: MSM with AHI (n = 54) had blood, seminal plasma and anal lavage collected for HIV RNA at baseline, days 3 and 7, and weeks 2, 4, 12 and 24. Data were compared between AHI stages: 1 (fourth-generation antigen-antibody combo immunoassay [IA]-, third-generation IA-, n = 15), 2 (fourth-generation IA+, third-generation IA-, n = 9) and 3 (fourth-generation IA+, third-generation IA vertical bar, western blot /indeterminate, n = 30) by randomization to five-drug (tenofovir vertical bar emtricitabine vertical bar efavirenz + raltegravir + maraviroc, n = 18) versus three-drug (tenofovir + emtricitabine + efavirenz, n = 18) regimens. Results: Mean age was 29 years and mean duration since HIV exposure was 15.4 days. Mean baseline HIV RNA was 5.5 in blood, 3.9 in seminal plasma and 2.6 log10 copies/ml in anal lavage (p<0.001). Blood and seminal plasma HIV RNA were higher in AHI Stage 3 compared to Stage 1 (p<0.01). Median time from ART initiation to HIV RNA <50 copies/ml was 60 days in blood, 15 days in seminal plasma and three days in anal lavage. Compared with the three-drug ART, the five-drug ART had a shorter time to HIV RNA <1500 copies/ml in blood (15 vs. 29 days, p = 0.005) and <50 copies/ml in seminal plasma (13 vs. 24 days, p = 0.048). Conclusions: Among MSM with AHI, HIV RNA was highest in blood, followed by seminal plasma and anal lavage. ART rapidly reduced HIV RNA in all compartments, with regimen intensified by raltegravir and maraviroc showing faster HIV RNA reductions in blood and seminal plasma. C1 [Phanuphak, Nittaya; Teeratakulpisarn, Nipat; van Griensven, Frits; Chomchey, Nitiya; Pinyakorn, Suteeraporn; Fletcher, James L. K.; Pattanachaiwit, Supanit; Phanuphak, Praphan] Thai Red Cross AIDS Res Ctr, Bangkok 10330, Thailand. [Phanuphak, Nittaya; Chomchey, Nitiya; Pinyakorn, Suteeraporn; Fletcher, James L. K.; Phanuphak, Praphan; Ananworanich, Jintanat] SEARCH, Bangkok, Thailand. [van Griensven, Frits; Pinyakorn, Suteeraporn; Phanuphak, Praphan] HIV NAT, Bangkok, Thailand. [Trichavaroj, Rapee] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Michael, Nelson; Kim, Jerome H.; Ananworanich, Jintanat] US Mil HIV Res Program, Bethesda, MD USA. [Michael, Nelson; Kim, Jerome H.] Walter Reed Army Inst Res Silver, Spring, MD USA. [Ananworanich, Jintanat] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. RP Phanuphak, N (reprint author), Thai Red Cross AIDS Res Ctr, SEARCH, 104 Rajdumri Rd, Bangkok 10330, Thailand. EM nittaya.p@trcarc.org FU US Military HIV Research Program, Walter Reed Army Institute of Research, Rockville, Maryland [W81XWH-07-2-0067]; Gilead (Truvada(R), Atripla(R)); Merck (Stocrin(R), Isentress(R)); ViiV Healthcare (Selzentry(R)) FX This study was funded by the US Military HIV Research Program, Walter Reed Army Institute of Research, Rockville, Maryland, under a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the US Department of Defense. Antiretroviral therapy was supported by Gilead (Truvada (R), Atripla (R)), Merck (Stocrin (R), Isentress (R)) and ViiV Healthcare (Selzentry (R)). Monogram Biosciences supported the Trofile (R) test. The content of this presentation is solely the responsibility of the authors and does not necessarily represent the official views of any of the institutions mentioned above. NR 37 TC 1 Z9 1 U1 0 U2 4 PU INT AIDS SOCIETY PI GENEVA PA AVENUE DE FRANCE 23, GENEVA, 1202, SWITZERLAND SN 1758-2652 J9 J INT AIDS SOC JI J. Int. AIDS Soc. PD MAY 7 PY 2015 VL 18 AR 19470 DI 10.7448/IAS.18.1.19470 PG 10 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA CH5UZ UT WOS:000354102100001 PM 25956171 ER PT J AU Krause, PR Bryant, PR Clark, T Dempsey, W Henchal, E Michael, NL Regules, JA Gruber, MF AF Krause, Philip R. Bryant, Paula R. Clark, Thomas Dempsey, Walla Henchal, Erik Michael, Nelson L. Regules, Jason A. Gruber, Marion F. TI Immunology of protection from Ebola virus infection SO SCIENCE TRANSLATIONAL MEDICINE LA English DT Article ID NONHUMAN-PRIMATES; WEST-AFRICA; IMMUNITY; ANTIBODIES; CHALLENGE; DISEASE AB A December 2014 meeting reviewed Ebola virus immunology relevant to vaccine development, including Ebola prevention, immunity, assay standardization, and regulatory considerations. Vaccinated humans appear to achieve immune responses comparable in magnitude with those associated with protection in nonhuman primates, suggesting that immunological data could be used to demonstrate vaccine efficacy. C1 [Krause, Philip R.; Henchal, Erik; Gruber, Marion F.] US FDA, Off Vaccines Res & Review, Ctr Biol Evaluat & Res, Silver Spring, MD 20993 USA. [Bryant, Paula R.; Dempsey, Walla] NIAID, Div Microbial & Infect Dis, NIH, Bethesda, MD 20892 USA. [Clark, Thomas] Ctr Dis Control & Prevent, Atlanta, GA USA. [Michael, Nelson L.; Regules, Jason A.] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Krause, PR (reprint author), US FDA, Off Vaccines Res & Review, Ctr Biol Evaluat & Res, Silver Spring, MD 20993 USA. EM philip.krause@fda.hhs.gov FU FDA; NIAID; CDC; Biomedical Advanced Research and Development Authority; U.S. Department of Defense FX We appreciate financial and logistical support for the meeting from FDA, NIAID, CDC, Biomedical Advanced Research and Development Authority, and U.S. Department of Defense. NR 25 TC 2 Z9 2 U1 1 U2 15 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 1946-6234 EI 1946-6242 J9 SCI TRANSL MED JI Sci. Transl. Med. PD MAY 6 PY 2015 VL 7 IS 286 AR 286ps11 DI 10.1126/scitranslmed.aaa8202 PG 4 WC Cell Biology; Medicine, Research & Experimental SC Cell Biology; Research & Experimental Medicine GA CI0MP UT WOS:000354431600003 PM 25947159 ER PT J AU Reynolds, P AF Reynolds, Phil TI Past failures and future problems: the psychology of irregular war SO SMALL WARS AND INSURGENCIES LA English DT Article DE institutional bias; causal attribution; psychology; irregular war; cultural variation; cognition; fundamental attribution error (FAE); USSOCOM ID ATTRIBUTION; PERSPECTIVE; OBEDIENCE; COGNITION; CULTURE AB Personal cognitive processes inform how individuals understand their environment. Cultural variation, fundamental attribution error, causal attribution, and durability bias create obstacles to Western understanding of irregular war and have created a significant institutional bias in how the US military perceives its enemies- a perception only somewhat softened after a decade of irregular war. United Special Operations Command (USSOCOM) is in a better position to overcome these problems through persistent engagement. In the event of major conflict, environmentally sensitized military planners will be better able to achieve military and policy objectives. C1 US Army, Schofield Barracks, HI 96786 USA. RP Reynolds, P (reprint author), US Army, Schofield Barracks, HI 96786 USA. EM philip.w.reynolds@gmail.com NR 39 TC 0 Z9 0 U1 1 U2 1 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0959-2318 EI 1743-9558 J9 SMALL WAR INSUR JI Small War Insur. PD MAY 4 PY 2015 VL 26 IS 3 BP 446 EP 458 DI 10.1080/09592318.2013.866426 PG 13 WC International Relations SC International Relations GA CI1CN UT WOS:000354478500006 ER PT J AU Sanodze, L Bautista, CT Garuchava, N Chubinidze, S Tsertsvadze, E Broladze, M Chitadze, N Sidamonidze, K Tsanava, S Akhvlediani, T Rivard, RG Mody, R Hepburn, MJ Elzer, PH Nikolich, MP Trapaidze, N AF Sanodze, Lia Bautista, Christian T. Garuchava, Natalia Chubinidze, Svetlana Tsertsvadze, Ekaterine Broladze, Mariam Chitadze, Nazibrola Sidamonidze, Ketevan Tsanava, Shota Akhvlediani, Tamar Rivard, Robert G. Mody, Rupal Hepburn, Matthew J. Elzer, Philip H. Nikolich, Mikeljon P. Trapaidze, Nino TI Expansion of brucellosis detection in the country of Georgia by screening household members of cases and neighboring community members SO BMC PUBLIC HEALTH LA English DT Article DE Brucellosis; Epidemiology; Zoonotic; Surveillance; Country of Georgia ID POLYMERASE-CHAIN-REACTION; MELITENSIS DNA; PCR METHODS; DIAGNOSIS; EPIDEMIOLOGY; SAMPLES; HUMANS; SERUM; SPP. AB Background: Brucellosis is considered as endemic zoonotic disease in the country of Georgia. However, the burden of the disease on a household level is not known. Therefore, this study sought to determine the benefits of active surveillance coupled to serological screening for the early detection of brucellosis among close contacts of brucellosis cases. Methods: We used an active surveillance approach to estimate the rate of seropositivity among household family members and neighboring community members of brucellosis index cases. All participants were screened using the serum tube agglutination test (SAT). Blood cultures were performed, obtained isolates were identified by a bacteriological algorithm, and confirmed as Brucella spp. using real-time PCR. Further confirmation of Brucella species was done using the AMOS PCR assay. Results: A total of 141 participants enrolled. Of these, 27 were brucellosis index cases, 86 were household family members, and 28 were neighboring community members. The serological evidence of brucellosis in the household member group was 7% and the rate at the household level was 21%. No screened community members were Brucella seropositive. Majority of brucellosis cases were caused by B. melitensis; only one index case was linked to B. abortus. Conclusion: We found evidence of brucellosis infection among household family members of brucellosis index cases. B. melitensis was the most common species obtained. Findings of this active surveillance study highlight the importance of screening household family members of brucellosis cases and of the use of culture methods to identify Brucella species in the country of Georgia. C1 [Sanodze, Lia; Garuchava, Natalia; Chubinidze, Svetlana; Tsertsvadze, Ekaterine; Broladze, Mariam; Chitadze, Nazibrola; Sidamonidze, Ketevan; Tsanava, Shota; Trapaidze, Nino] Natl Ctr Dis Control & Publ Hlth, Tbilisi, Rep of Georgia. [Bautista, Christian T.; Nikolich, Mikeljon P.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Sidamonidze, Ketevan] I Javakhishvili Tbilisi State Univ, Tbilisi, Rep of Georgia. [Akhvlediani, Tamar; Nikolich, Mikeljon P.; Trapaidze, Nino] US Army Med Res Unit Georgia, Tbilisi, Rep of Georgia. [Rivard, Robert G.; Mody, Rupal; Hepburn, Matthew J.] US Army Med Res Inst Infect Dis, Ft Detrick, MD USA. [Elzer, Philip H.] Louisiana State Univ, AgCtr, Sch Anim Sci, Baton Rouge, LA 70803 USA. RP Trapaidze, N (reprint author), Natl Ctr Dis Control & Publ Hlth, Tbilisi, Rep of Georgia. EM trapaidze@yahoo.com FU Defense Threat Reduction Agency (DTRA) through the Cooperative Biological Engagement Program [CBEP-CBR-GG17] FX This study was made possible by the hard work and dedication of multiple host-country investigators. The authors thank all the volunteers for participating in this study and study personnel for their assistance in enrollment and follow-up visits, as well as Sebastian-Santiago for technical assistance. This study was funded by the Defense Threat Reduction Agency (DTRA) through the Cooperative Biological Engagement Program (CBEP-CBR-GG17). NR 27 TC 4 Z9 4 U1 0 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2458 J9 BMC PUBLIC HEALTH JI BMC Public Health PD MAY 2 PY 2015 VL 15 AR 459 DI 10.1186/s12889-015-1761-y PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CI1MQ UT WOS:000354508700001 PM 25934639 ER PT J AU Baehr, C AF Baehr, Craig TI Complexities in Hybridization: Professional Identities and Relationships in Technical Communication SO TECHNICAL COMMUNICATION LA English DT Article DE professionalism; technical communication; skills; job titles; relationships; organizations AB Purpose: This article provides a snapshot of how industry leaders currently conceptualize our identities and relationships, as well as some of the challenges we continue to face as a profession. Method: This study used a modified Delphi method. To gather data, we used two sets of survey questions and two structured interviews. Results: Technical communicators are functioning as agile, adaptable, and multi-specialists in a broad range of organizational functions. They have become increasingly visible and valuable assets throughout a project lifecycle, and in many cases are able to define their own roles, which include team leadership and management responsibilities. Conclusion: Technical communicators continue to serve in core functional responsibilities in a wide range of industries. C1 [Baehr, Craig] STC, Vijayawada, Andhra Pradesh, India. [Baehr, Craig] Texas Tech Univ, Tech Commun, Lubbock, TX 79409 USA. [Baehr, Craig] Tech Commun Body Knowledge Comm, Fairfax, VA 22031 USA. [Baehr, Craig] STC Acad SIG, Epping, NH 03042 USA. [Baehr, Craig] US Army Corps Engineers, Washington, DC 20314 USA. RP Baehr, C (reprint author), STC, Vijayawada, Andhra Pradesh, India. EM craig.baehr@ttu.edu NR 14 TC 4 Z9 4 U1 1 U2 1 PU SOC TECHNICAL COMMUNICATION PI FAIRFAX PA 9401 LEE HIGHWAY, STE 300, FAIRFAX, VA 22031 USA SN 0049-3155 J9 TECH COMMUN-STC JI Tech. Commun. PD MAY PY 2015 VL 62 IS 2 BP 104 EP 117 PG 14 WC Communication SC Communication GA DE6GC UT WOS:000370730900003 ER PT J AU Dubinsky, JM AF Dubinsky, James M. TI Products and Processes: Transition from "Product Documentation to ... Integrated Technical Content" SO TECHNICAL COMMUNICATION LA English DT Article DE content management; content experience; products; processes; how-to videos; user advocates; Agile; design; productivity ID COMMUNICATION; FUTURE AB Purpose: To examine the attitudes and perspectives of individuals in successful companies who manage technical communicators with a specific focus on the products and processes that make up the bulk of their work. Method: This study used a modified Delphi method. To gather data, we used two sets of survey questions and two structured interviews. Results: This research helped to further explain the relationship between what technical communicators produce and how these products function in situating or framing their producers in relation to other subfields/related disciplines, such as UX design, information design, knowledge management, usability, and information architecture. Conclusion: While there is general agreement among the managers that the role of the technical communicator has to expand, there is no one clear agreed-upon strategy. Some companies are obtaining success using Agile methodology, while others are finding that this methodology, while stressing adaptability, is not easy to introduce. Corporate cultures do not change overnight. Still, integrated teams, a key component of Agile, are taking hold in most cultures. Equally important, the shift away from writing documents to directing content is well underway. The key now, as it has been for decades, is for technical communicators to highlight their value and make their contributions more visible. C1 [Dubinsky, James M.] Virginia Tech, Dept English, Blacksburg, VA 24061 USA. [Dubinsky, James M.] Virginia Tech, CSRS, Blacksburg, VA 24061 USA. [Dubinsky, James M.] Profess Writing Program, College Pk, MD 20742 USA. [Dubinsky, James M.] VTs Ctr Student Engagement & Community Partnershi, Blacksburg, VA 24061 USA. [Dubinsky, James M.] US Army, Ft Knox, KY 40122 USA. RP Dubinsky, JM (reprint author), Virginia Tech, Dept English, Blacksburg, VA 24061 USA. EM Dubinsky@vt.edu NR 38 TC 4 Z9 4 U1 3 U2 4 PU SOC TECHNICAL COMMUNICATION PI FAIRFAX PA 9401 LEE HIGHWAY, STE 300, FAIRFAX, VA 22031 USA SN 0049-3155 J9 TECH COMMUN-STC JI Tech. Commun. PD MAY PY 2015 VL 62 IS 2 BP 118 EP 134 PG 17 WC Communication SC Communication GA DE6GC UT WOS:000370730900004 ER PT J AU Shields, BA Pidcoke, HF Chung, KK Wade, CE Martini, WZ Renz, EM Wolf, SE AF Shields, Beth A. Pidcoke, Heather F. Chung, Kevin K. Wade, Charles E. Martini, Wenjun Z. Renz, Evan M. Wolf, Steven E. TI Are Visceral Proteins Valid Markers for Nutritional Status in the Burn Intensive Care Unit? SO JOURNAL OF BURN CARE & RESEARCH LA English DT Article ID RESTING ENERGY-EXPENDITURE; THERMALLY INJURED PATIENTS; NITROGEN; THERAPY; PATIENT; BALANCE AB The aim of this study was to determine whether visceral protein levels increase under positive nitrogen balance during times of decrease in acute-phase reactant levels in patients with burn injury. This was a post hoc analysis of a prospective, interventional study approved by the local institutional review board. A total of 10 subjects between the ages of 18 and 72 with >= 20% total body surface area burn were enrolled over a 14-month period. Data were collected for five subjects (average age of 28 +/- 8 years and total body surface area burn of 69 +/- 15%) who met the inclusion criteria. Changes in visceral protein levels were examined along with nitrogen balance and acute-phase reactants when the subjects were on enteral nutrition, and the proteins were not examined during times of acute kidney injury. Descriptive statistics were performed, and linear regression was used to analyze the association of visceral proteins and nitrogen balance during times that acute-phase reactant levels were decreasing. The subjects received an average of 3044 +/- 1613 kcal/day (39 +/- 20 kcal/kg), meeting 72% of caloric goals and achieving positive nitrogen balance during 68% of the 40 weekly measurements, with 174 +/- 85 g of protein intake per day (2.2 +/- 1.1 g/kg). There was a weak relationship between nitrogen balance and changes in visceral protein levels during times that the acute-phase reactant levels were decreasing (P >.05). Visceral proteins were found to be poor markers of nutritional status. This study is unique because the subjects were able to achieve positive nitrogen balance despite severe burns. C1 [Shields, Beth A.] San Antonio Mil Med Ctr, San Antonio, TX USA. [Pidcoke, Heather F.; Chung, Kevin K.; Martini, Wenjun Z.; Renz, Evan M.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Chung, Kevin K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Wade, Charles E.] Univ Texas Hlth Sci Ctr Houston, Dept Surg, Ctr Translat Injury Res, Houston, TX 77030 USA. [Wolf, Steven E.] Univ Texas SW Med Ctr Dallas, Dept Surg, Dallas, TX 75390 USA. RP Shields, BA (reprint author), US Army, Inst Surg Res, Burn Ctr, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM beth.shields@amedd.army.mil FU National Institutes of General Medical Sciences [1 R01 GM063120] FX The study was supported by the National Institutes of General Medical Sciences 1 R01 GM063120. NR 20 TC 1 Z9 1 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1559-047X EI 1559-0488 J9 J BURN CARE RES JI J. Burn Care Res. PD MAY-JUN PY 2015 VL 36 IS 3 BP 375 EP 380 DI 10.1097/BCR.0000000000000101 PG 6 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA DD1UI UT WOS:000369707000018 PM 25055006 ER PT J AU Korp, K Richard, R Hawkins, D AF Korp, Katie Richard, Reg Hawkins, Donald TI Refining the Idiom "Functional Range of Motion" Related to Burn Recovery SO JOURNAL OF BURN CARE & RESEARCH LA English DT Article ID 3 FEEDING ACTIVITIES; HUMAN JOINT MOTION; UPPER EXTREMITY; WRIST MOTION; STAIR ASCENT; PART II; FLEXIBLE ELECTROGONIOMETRY; ISB RECOMMENDATION; KNEE ARTHROPLASTY; LIMB JOINTS AB The term "functional" in burn rehabilitation has gained widespread use to describe a patient's recovery after burn injury. But what truly is "functional" when applied to a patient recovering from burn injury? A literature search was performed for information defining "functional" range of motion ( ROM). Maximum upper and lower ROM values to perform a variety of daily activities were abstracted and compared with published outcomes of patient groups recovered from burn injury. Seventy references were reviewed leading to categorizing 11 activities and 26 joint motions. Seven burn outcome articles were found that classified patient scar contracture severity based on ROM. In comparing the results, many burn survivors with severe burn scar contractures could be considered "functional." Refinement of the term "functional" is needed related to burn outcomes. Functional ROM of a particular joint to perform one specific task may be insufficient to perform a variety of other tasks when all planes of motion are considered. Use of the term "functional" to describe a patient's outcome should be used in a guarded manner. C1 [Korp, Katie; Richard, Reg; Hawkins, Donald] US Army Inst Surg Res, Burn Ctr, JBSA Ft Sam Houston, Ft Sam Houston, TX 78234 USA. RP Richard, R (reprint author), US Army Inst Surg Res, JBSA Ft Sam Houston, 3698 Chambers Pass,STE B 3611, Ft Sam Houston, TX 78234 USA. NR 60 TC 1 Z9 1 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1559-047X EI 1559-0488 J9 J BURN CARE RES JI J. Burn Care Res. PD MAY-JUN PY 2015 VL 36 IS 3 BP E136 EP E145 DI 10.1097/BCR.0000000000000149 PG 10 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA DD1UI UT WOS:000369707000004 PM 25162944 ER PT J AU Niedzielski, S Chapman, T AF Niedzielski, Stephanie Chapman, Ted TI Changes in Burn Scar Contracture: Utilization of a Severity Scale and Predictor of Return to Duty for Service Members SO JOURNAL OF BURN CARE & RESEARCH LA English DT Article ID HAND QUESTIONNAIRE; FUNCTIONAL RANGE; ENDURING FREEDOM; IMPAIRMENT; DISABILITY; MOTION; WORK; REHABILITATION; RECOVERY; INJURIES AB A medical records review of Operation Iraqi Freedom and Operation Enduring Freedom burn injury survivors admitted to the U.S. Army Institute of Surgical Research Burn Center from April 2003 to August 2005 was conducted. The study proposed the use of a newly developed scale, the Burn Scar Contracture Severity Scale, to potentially provide standardization in quantifying burn scar contracture severity. Changes in the active range of motion from in-patient discharge to out-patient follow-up of individuals with upper extremity burn injuries were compared. Changes in the impairment via American Medical Association impairment scores and perceived disability using the disabilities of the arm, shoulder, and hand questionnaire scores from the in-patient discharge to the out-patient follow-up were also compared. A weak, yet positive correlation (r =.417, .451, P =.001) between the proposed scale and the disabilities of the arm, shoulder, and hand questionnaire and the American Medical Association impairment scores was found, respectively. A receiver operating characteristic curve analysis revealed a cut-off score of 6.5 for the burn scar contracture severity scale, indicating that individuals scoring below a 6.5 returned to duty and those scoring above 6.5 did not return to duty. Results suggest that the burn scar contracture severity scale is able to discriminate between the individuals who returned to duty and those who did not return to duty. C1 [Niedzielski, Stephanie] US Army, Dept Occupat Therapy, Baylor DScOT, Ft Sam Houston, TX USA. [Chapman, Ted] US Army, Brooke Army Med Ctr, San Antonio, TX USA. RP Niedzielski, S (reprint author), US Army, DScOT, Dept Occupat Therapy, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 29 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1559-047X EI 1559-0488 J9 J BURN CARE RES JI J. Burn Care Res. PD MAY-JUN PY 2015 VL 36 IS 3 BP E212 EP E219 DI 10.1097/BCR.0000000000000148 PG 8 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA DD1UI UT WOS:000369707000011 ER PT J AU Zhang, L Phanuphak, N Henderson, K Nonenoy, S Srikaew, S Shattock, AJ Kerr, CC Omune, B van Griensven, F Osornprasop, S Oelrichs, R Ananworanich, J Wilson, DP AF Zhang, Lei Phanuphak, Nittaya Henderson, Klara Nonenoy, Siriporn Srikaew, Sasiwan Shattock, Andrew J. Kerr, Cliff C. Omune, Brenda van Griensven, Frits Osornprasop, Sutayut Oelrichs, Robert Ananworanich, Jintanat Wilson, David P. TI Scaling up of HIV treatment for men who have sex with men in Bangkok: a modelling and costing study SO LANCET HIV LA English DT Article ID ANTIRETROVIRAL THERAPY; PREVENTION; THAILAND; IMPACT; IMPLEMENTATION; INFECTION; RESPONSES; PROGRAMS; EPIDEMIC; HIV/AIDS AB Background Despite the high prevalence of HIV in men who have sex with men (MSM) in Bangkok, little investment in HIV prevention for MSM has been made. HIV testing and treatment coverage remains low. Through a pragmatic programme-planning approach, we assess possible service linkage and provision of HIV testing and antiretroviral treatment (ART) to MSM in Bangkok, and the most cost-effective scale-up strategy. Methods We obtained epidemiological and service capacity data from the Thai National Health Security Office database for 2011. We surveyed 13 representative medical facilities for detailed operational costs of HIV-related services for sexually active MSM (defined as having sex with men in the past 12 months) in metropolitan Bangkok. We estimated the costs of various ART scale-up scenarios, accounting for geographical accessibility across Bangkok. We used an HIV transmission population-based model to assess the cost-effectiveness of the scenarios. Findings For present HIV testing (23% [95% CI 17-36] of MSM at high risk in 2011) and ART provision (20% of treatment-eligible MSM at high risk on ART in 2011) to be sustained, a US$73.8 million ($51.0 million to $97.0 million) investment during the next decade would be needed, which would link an extra 43 000 (27 900-58 000) MSM at high risk to HIV testing and 5100 (3500-6700) to ART, achieving an ART coverage of 44% for MSM at high risk in 2022. An additional $55.3 million investment would link an extra 46 700 (30 300-63200) MSM to HIV testing and 12 600 (8800-16600) to ART, achieving universal ART coverage of this population by 2022. This increased investment is achievable within present infrastructure capacity. Consequently, an estimated 5100 (3600-6700) HIV-related deaths and 3700 (2600-4900) new infections could be averted in MSM by 2022, corresponding to a 53% reduction in deaths and a 35% reduction in infections from 2012 levels. The expansion would cost an estimated $10 809 (9071-13 274) for each HIV-related death, $14783 (12 389-17960) per new infection averted, and $351 (290-424) per disability-adjusted life-year averted. Interpretation Spare capacity in Bangkok's medical facilities can be used to expand ART access for MSM with large epidemiological benefits. The expansion needs increased funding directed to MSM services, but given the epidemiological trends, is probably cost effective. Our modelling approach and outcomes are likely to be applicable to other settings. C1 [Zhang, Lei; Henderson, Klara; Shattock, Andrew J.; Kerr, Cliff C.; Wilson, David P.] Univ New S Wales, Kirby Inst, Kensington, NSW 2052, Australia. [Phanuphak, Nittaya; Nonenoy, Siriporn; Srikaew, Sasiwan; Omune, Brenda; van Griensven, Frits; Ananworanich, Jintanat] Thai Red Cross Soc AIDS Res Ctr, Bangkok, Thailand. [Osornprasop, Sutayut; Oelrichs, Robert] World Bank Grp, Washington, DC USA. [Ananworanich, Jintanat] US Mil, Walter Reed Army Inst Res, HIV Res Program, Silver Spring, MD USA. [Ananworanich, Jintanat] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. RP Wilson, DP (reprint author), Univ New S Wales, Kirby Inst, Kensington, NSW 2052, Australia. EM dwilson@unsw.edu.au OI Henderson, Klara/0000-0003-4468-1306; Zhang, Lei/0000-0003-2343-084X; Shattock, Andrew/0000-0002-2285-8425 FU World Bank Group; Australian National Health and Medical Research Council; Australian Government Department of Health and Ageing FX This study was funded by the World Bank Group with support from the Australian National Health and Medical Research Council. The Kirby Institute is funded by the Australian Government Department of Health and Ageing. The views expressed in this publication do not necessarily represent the position of the Australian Government, US Army, or Department of Defense. The Kirby Institute is affiliated with the University of New South Wales. The findings, interpretations, and conclusions expressed in this work are those of the authors and do not necessarily reflect the views of the World Bank, its Board of Executive Directors, or the governments that they represent. We wish to thank the Thai Ministry of Public Health, the National Health Security Office Program, and managers and other staff in all sites that were surveyed. NR 40 TC 4 Z9 4 U1 0 U2 4 PU ELSEVIER INC PI SAN DIEGO PA 525 B STREET, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 2352-3018 J9 LANCET HIV JI Lancet HIV PD MAY PY 2015 VL 2 IS 5 BP E200 EP E207 DI 10.1016/S2352-3018(15)00020-X PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA CU8KY UT WOS:000363792500010 PM 26423002 ER PT J AU Manocheewa, S Lanxon-Cookson, EC Liu, Y Swain, JV McClure, J Rao, U Maust, B Deng, WJ Sunshine, JE Kim, M Rolland, M Mullins, JI AF Manocheewa, Siriphan Lanxon-Cookson, Erinn C. Liu, Yi Swain, J. Victor McClure, Jan Rao, Ushnal Maust, Brandon Deng, Wenjie Sunshine, Justine E. Kim, Moon Rolland, Morgane Mullins, James I. TI Pairwise Growth Competition Assay for Determining the Replication Fitness of Human Immunodeficiency Viruses SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS LA English DT Article DE Immunology; Issue 99; HIV-1; Recombinant; Mutagenesis; Viral replication fitness; Growth competition; Fitness calculation ID EX-VIVO; RESISTANCE MUTATIONS; GAG-PROTEASE; SUBTYPE-C; IN-VITRO; TYPE-1; CAPACITY; ESCAPE; REDUCTIONS; INHIBITORS AB In vitro fitness assays are essential tools for determining viral replication fitness for viruses such as HIV-1. Various measurements have been used to extrapolate viral replication fitness, ranging from the number of viral particles per infectious unit, growth rate in cell culture, and relative fitness derived from multiple-cycle growth competition assays. Growth competition assays provide a particularly sensitive measurement of fitness since the viruses are competing for cellular targets under identical growth conditions. There are several experimental factors to consider when conducting growth competition assays, including the multiplicity of infection (MOI), sampling times, and viral detection and fitness calculation methods. Each factor can affect the end result and hence must be considered carefully during the experimental design. The protocol presented here includes steps from constructing a new recombinant HIV-1 clone to performing growth competition assays and analyzing the experimental results. This protocol utilizes experimental parameter values previously shown to yield consistent and robust results. Alternatives are discussed, as some parameters need to be adjusted according to the cell type and viruses being studied. The protocol contains two alternative viral detection methods to provide flexibility as the availability of instruments, reagents and expertise varies between laboratories. C1 [Manocheewa, Siriphan; Lanxon-Cookson, Erinn C.; Liu, Yi; Swain, J. Victor; McClure, Jan; Rao, Ushnal; Maust, Brandon; Deng, Wenjie; Sunshine, Justine E.; Kim, Moon; Mullins, James I.] Univ Washington, Dept Microbiol, Seattle, WA 98195 USA. [Mullins, James I.] Univ Washington, Dept Med, Seattle, WA 98195 USA. [Mullins, James I.] Univ Washington, Dept Lab Med, Seattle, WA 98195 USA. [Rolland, Morgane] Walter Reed Army Inst Res, US Mil HIV Res Program, Washington, DC USA. [Rolland, Morgane] Henry M Jackson Fdn, Washington, DC USA. RP Mullins, JI (reprint author), Univ Washington, Dept Microbiol, Seattle, WA 98195 USA. EM jmullins@u.washington.edu FU US Public Health Services [P01AI057005, R01AI047734, R01AI111806]; Functional Profiling and Computational Biology Core of the University of Washington's Center for AIDS Research [P30 AI027757] FX These studies were funded by US Public Health Services grants P01AI057005, R01AI047734, R01AI111806 and the Functional Profiling and Computational Biology Core of the University of Washington's Center for AIDS Research (P30 AI027757). NR 36 TC 0 Z9 0 U1 2 U2 3 PU JOURNAL OF VISUALIZED EXPERIMENTS PI CAMBRIDGE PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA SN 1940-087X J9 JOVE-J VIS EXP JI J. Vis. Exp. PD MAY PY 2015 IS 99 AR e52610 DI 10.3791/52610 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CR7MV UT WOS:000361535300026 PM 25993602 ER PT J AU VandenBerge, DR Brandon, TL Wielputz, MP AF VandenBerge, D. R. Brandon, T. L. Wielputz, M. P. TI Highly Organic Fill for Levee Stability Berms SO GEOTECHNICAL TESTING JOURNAL LA English DT Article DE stability berm; organic clay; compaction; unconfined compression; jet erosion index ID MATTER AB Earth berms constructed of cohesive fill are often used to improve the stability of levees. In some parts of the United States, many of the locally available cohesive soils contain high organic content (> 9 %), which has historically prevented their use for stability berms. This study investigated the compaction characteristics, undrained strength, and erodibility of eight samples of clay from Louisiana with organic content ranging from 1.7 % to 29 % to evaluate their potential use for stability berms. The target total unit weight of 15.7 kN/m(3) was found to be difficult to attain for soils with organic content above about 9 %. The desired minimum undrained strength of 19.2 kPa was easily attained for all of the organic content at water content up to 6 % wet of optimum. The erosion resistance, measured using the jet erosion test, stayed the same or increased as the organic content of the fill increased. Based on these test results, soils with organic content in excess of 9 % are suitable for use as stability berm fill, provided that a lower total unit weight can be used in design. C1 [VandenBerge, D. R.; Brandon, T. L.] Virginia Tech, Blacksburg, VA 24061 USA. [Wielputz, M. P.] US Army Corps Engineers, Marietta, GA 30062 USA. RP VandenBerge, DR (reprint author), Virginia Tech, 19 Patton Hall, Blacksburg, VA 24061 USA. NR 24 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 USA SN 0149-6115 EI 1945-7545 J9 GEOTECH TEST J JI Geotech. Test. J. PD MAY PY 2015 VL 38 IS 3 AR GTJ20140151 DI 10.1520/GTJ20140151 PG 12 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA CR2HY UT WOS:000361149700005 ER PT J AU Smith, TJ Barrett, A Anderson, D Wilson, MA Young, AJ Montain, SJ AF Smith, Tracey J. Barrett, Ann Anderson, Danielle Wilson, Marques A. Young, Andrew J. Montain, Scott J. TI Absorption of omega-3 fats from carbohydrate and proteinaceous food matrices before and after storage SO FOOD SCIENCE & NUTRITION LA English DT Article DE Absorption; encapsulation; fatty acids; omega 3 fatty acids ID FISH-OIL; OMEGA-3-FATTY-ACIDS; MILITARY; INJURY; ACIDS AB Development of n-3 fortified, shelf-stable foods is facilitated by encapsulated docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), since natural n-3 food sources cannot withstand high temperature and prolonged shelf life. Organoleptic stability of n-3 fortified, shelf-stable foods has been demonstrated, but chemical changes in the food matrix throughout storage could conceivably impact digestibility of the protein-based encapsulant thereby compromising n-3 bioavailability. We assessed the effect of prolonged high-temperature storage and variations in food matrix (proteinaceous or carbohydrate) on the time course and magnitude of blood fatty acids changes associated with ingestion of n-3 fortified foods. Low-protein (i.e., cake) and high-protein (i.e., meat sticks) items were supplemented with 600 mg encapsulated DHA+EPA, and frozen either immediately after production (FRESH) or after 6 months storage at 100 degrees F (STORED). Fourteen volunteers consumed one item per week (randomized) for 4 weeks. Blood samples obtained at baseline, 2, 4, and 6 h post-consumption were analyzed for circulating long-chain omega 3 fatty acids (LCn3). There was no difference in LCn3 area under the curve between items. LCn3 in response to cakes peaked at 2-h (FRESH: 54.0 +/- 16.8 mu g/mL, + 18%; STORED: 53.0 +/- 13.2 mu g/mL, + 20%), while meats peaked at 4-h (FRESH: 51.9 +/- 12.5 mu g/mL, + 22%; STORED: 53.2 +/- 16.9 mu g/mL, + 18%). There were no appreciable differences in time course or magnitude of n-3 appearance in response to storage conditions for either food types. Thus, bioavailability of encapsulated DHA/EPA, within low-and high-protein food items, was not affected by high-temperature shelf-storage. A shelf-stable, low-or high-protein food item with encapsulated DHA/EPA is suitable for use in shelf-stable foods. C1 [Smith, Tracey J.; Wilson, Marques A.; Young, Andrew J.; Montain, Scott J.] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA. [Barrett, Ann; Anderson, Danielle] Natick Soldier Res & Engn Ctr, Combat Feeding Directorate, Performance Optimizat Res Team, Natick, MA USA. RP Smith, TJ (reprint author), US Army Res Inst Environm Med, Mil Nutr Div, Kansas St,Bldg 42, Natick, MA 01760 USA. EM tracey.smith10.civ@mail.mil NR 14 TC 0 Z9 0 U1 3 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2048-7177 J9 FOOD SCI NUTR JI Food Sci. Nutr. PD MAY PY 2015 VL 3 IS 3 BP 195 EP 201 DI 10.1002/fsn3.204 PG 7 WC Food Science & Technology SC Food Science & Technology GA CP8CC UT WOS:000360117700005 PM 25987994 ER PT J AU Herbert, AS Davidson, C Kuehne, AI Bakken, R Braigen, SZ Gunn, KE Whelan, SP Brummelkamp, TR Twenhafel, NA Chandran, K Walkley, SU Dye, JM AF Herbert, Andrew S. Davidson, Cristin Kuehne, Ana I. Bakken, Russell Braigen, Stephen Z. Gunn, Kathryn E. Whelan, Sean P. Brummelkamp, Thijn R. Twenhafel, Nancy A. Chandran, Kartik Walkley, Steven U. Dye, John M. TI Niemann-Pick C1 Is Essential for Ebolavirus Replication and Pathogenesis In Vivo SO MBIO LA English DT Article ID LAKE-VICTORIA-MARBURGVIRUS; VIRUS ENTRY REQUIRES; ZAIRE-EBOLAVIRUS; FILOVIRUS ENTRY; CHOLESTEROL; DISEASE; RECEPTOR; GLYCOPROTEIN; PROTEIN; NPC1 AB Recent work demonstrated that the Niemann-Pick C1 (NPC1) protein is an essential entry receptor for filoviruses. While previous studies focused on filovirus entry requirements of NPC1 in vitro, its roles in filovirus replication and pathogenesis in vivo remain unclear. Here, we evaluated the importance of NPC1, and its partner in cholesterol transport, NPC2, by using a mouse model of Ebolavirus (EBOV) disease. We found that, whereas wild-type mice had high viral loads and succumbed to EBOV infection, Npc1(-/-) mice were entirely free of viral replication and completely protected from EBOV disease. Interestingly, Npc1(+/-) mice transiently developed high levels of viremia, but were nevertheless substantially protected from EBOV challenge. We also found Npc2(-/-) mice to be fully susceptible to EBOV infection, while Npc1(-/-) mice treated to deplete stored lysosomal cholesterol remained completely resistant to EBOV infection. These results provide mechanistic evidence that NPC1 is directly required for EBOV infection in vivo, with little or no role for NPC1/NPC2-dependent cholesterol transport. Finally, we assessed the in vivo antiviral efficacies of three compounds known to inhibit NPC1 function or NPC1-glycoprotein binding in vitro. Two compounds reduced viral titers in vivo and provided a modest, albeit not statistically significant, degree of protection. Taken together, our results show that NPC1 is critical for replication and pathogenesis in animals and is a bona fide target for development of antifilovirus therapeutics. Additionally, our findings with Npc1(-/-) mice raise the possibility that individuals heterozygous for NPC1 may have a survival advantage in the face of EBOV infection. IMPORTANCE Researchers have been searching for an essential filovirus receptor for decades, and numerous candidate receptors have been proposed. However, none of the proposed candidate receptors has proven essential in all in vitro scenarios, nor have they proven essential when evaluated using animal models. In this report, we provide the first example of a knockout mouse that is completely refractory to EBOV infection, replication, and disease. The findings detailed here provide the first critical in vivo data illustrating the absolute requirement of NPC1 for filovirus infection in mice. Our work establishes NPC1 as a legitimate target for the development of anti-EBOV therapeutics. However, the limited success of available NPC1 inhibitors to protect mice from EBOV challenge highlights the need for new molecules or approaches to target NPC1 in vivo. C1 [Herbert, Andrew S.; Kuehne, Ana I.; Bakken, Russell; Gunn, Kathryn E.; Twenhafel, Nancy A.; Dye, John M.] US Army Med Res Inst Infect Dis, Frederick, MD USA. [Davidson, Cristin; Walkley, Steven U.] Albert Einstein Coll Med, Dominick P Purpura Dept Neurosci, Bronx, NY 10467 USA. [Braigen, Stephen Z.; Chandran, Kartik] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10467 USA. [Whelan, Sean P.] Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Boston, MA 02115 USA. [Brummelkamp, Thijn R.] Netherlands Canc Inst, Amsterdam, Netherlands. [Gunn, Kathryn E.] Mt St Marys Univ, Dept Sci, Emmitsburg, MD USA. RP Chandran, K (reprint author), Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10467 USA. EM kchandra@aecom.yu.edu; steve.walkley@einstein.yu.edu; john.m.dye1@us.army.mil FU NIAID NIH HHS [R01 AI101436]; NIGMS NIH HHS [T32 GM007491] NR 56 TC 10 Z9 10 U1 2 U2 9 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 2150-7511 J9 MBIO JI mBio PD MAY-JUN PY 2015 VL 6 IS 3 AR e00565-15 DI 10.1128/mBio.00565-15 PG 12 WC Microbiology SC Microbiology GA CM7JH UT WOS:000357867400050 PM 26015498 ER PT J AU Sun, J Choi, KK Jhabvala, MD Jhabvala, CA Waczynski, A Olver, K AF Sun, J. Choi, K. K. Jhabvala, M. D. Jhabvala, C. A. Waczynski, A. Olver, K. TI Advanced inductively coupled plasma etching processes for fabrication of resonator-quantum well infrared photodetector SO INFRARED PHYSICS & TECHNOLOGY LA English DT Article; Proceedings Paper CT 8th International Workshop on Quantum Structure Infrared Photodetectors (QSIP) CY JUN 29-JUL 03, 2014 CL Santa Fe, NM SP Univ New Mexico, Georgia State Univ, NASA Jet Propuls Lab, AF Res Lab, Army Res Off DE Inductively coupled plasma etching; Resonator-quantum well infrared; photodetectors focal plane array; GaAs substrate removal ID DAMAGE; GAAS; SICL4; TIME; INP AB Resonator-quantum well infrared photodetectors (R-QWIPs) are the next generation of QWIP detectors that use resonances to increase the quantum efficiency (QE). To achieve the expected performance, the detector geometry must be produced in precise specification. In particular, the height of the diffractive elements (DE) and the thickness of the active resonator must be uniformly and accurately realized to within 0.05 mu m accuracy and the substrates of the detectors have to be removed totally. To achieve these specifications, two optimized inductively coupled plasma (ICP) etching processes are developed. Using these etching techniques, we have fabricated a number of R-QWIP test detectors and FPAs with the required dimensions and completely removed the substrates of the test detectors and FPAs. Their QE spectra were tested to be in close agreement with the theoretical predictions. The operability and spectral non-uniformity of the FPA is about 99.57% and 3% respectively. Published by Elsevier B.V. C1 [Sun, J.] US Army, Res Lab, Adelphi, MD 20783 USA. NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA. RP Sun, J (reprint author), US Army, Res Lab, Adelphi, MD 20783 USA. NR 14 TC 3 Z9 3 U1 4 U2 11 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1350-4495 EI 1879-0275 J9 INFRARED PHYS TECHN JI Infrared Phys. Technol. PD MAY PY 2015 VL 70 BP 25 EP 29 DI 10.1016/j.infrared.2014.09.022 PG 5 WC Instruments & Instrumentation; Optics; Physics, Applied SC Instruments & Instrumentation; Optics; Physics GA CL8OM UT WOS:000357234000006 ER PT J AU Henry, NC Knorr, DB Williams, KS Baril, N Nallon, E Lenhart, JL Andzelm, JW Pellegrino, J Tidrow, M Cleveland, E Bandara, S AF Henry, Nathan C. Knorr, Daniel B., Jr. Williams, Kristen S. Baril, Neil Nallon, Eric Lenhart, Joseph L. Andzelm, Jan W. Pellegrino, Joseph Tidrow, Meimei Cleveland, Erin Bandara, Sumith TI Chemical and physical passivation of type II strained-layer superlattice devices by means of thiolated self-assembled monolayers and polymer encapsulates SO INFRARED PHYSICS & TECHNOLOGY LA English DT Article; Proceedings Paper CT 8th International Workshop on Quantum Structure Infrared Photodetectors (QSIP) CY JUN 29-JUL 03, 2014 CL Santa Fe, NM SP Univ New Mexico, Georgia State Univ, NASA Jet Propuls Lab, AF Res Lab, Army Res Off DE InAs/GaSb superlattice; Infrared detector; Passivation; Thiol; SAM; Polymer ID SEMICONDUCTOR SURFACES; MOLECULES; INAS AB The efficacy of solution deposition of thiolated self-assembled monolayers (SAMs) has been explored for the purpose of passivating III-V type II superlattice (T2SL) photodetectors, more specifically a p-type heterojunction device. Sulfur passivation has previously been achieved on T2SL devices. However, degradation over time, temperature sensitivity and inconsistent reproducibility necessitate a physical encapsulate that can chemically bond to the chemical passivant. Thus, this research investigates two passivation methods, surface passivation with a thiol monolayer and passivation with a polymer encapsulant with a view toward future combination of these techniques. Analysis of the physical and chemical condition of the surface prior to deposition assisted in the development of ideal processes for optimized film quality. Successful deposition was facilitated by in situ oxide removal. Various commercially available functional (cysteamine) and non-functional (alkane) thiolated monolayers were investigated. Dark current was reduced by 3 orders of magnitude and achieved negligible surface leakage at low bias levels. The lowest dark current result, 7.69 x 10(-6) A/cm(2) at 50 mV, was achieved through passivation with cysteamine. (C) 2014 Elsevier B.V. All rights reserved. C1 [Henry, Nathan C.] Fulcrum Co, Centreville, VA 20120 USA. [Henry, Nathan C.; Baril, Neil; Nallon, Eric; Pellegrino, Joseph; Tidrow, Meimei; Bandara, Sumith] US Army RDECOM CERDEC NVESD, Ft Belvoir, VA 22060 USA. [Knorr, Daniel B., Jr.; Williams, Kristen S.; Lenhart, Joseph L.; Andzelm, Jan W.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Cleveland, Erin] US Navy, Res Lab, Washington, DC 20375 USA. RP Henry, NC (reprint author), 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA. EM info@nvl.army.mil NR 26 TC 1 Z9 1 U1 0 U2 13 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1350-4495 EI 1879-0275 J9 INFRARED PHYS TECHN JI Infrared Phys. Technol. PD MAY PY 2015 VL 70 BP 48 EP 52 DI 10.1016/j.infrared.2014.10.015 PG 5 WC Instruments & Instrumentation; Optics; Physics, Applied SC Instruments & Instrumentation; Optics; Physics GA CL8OM UT WOS:000357234000011 ER PT J AU Baril, N Bandara, S Hoeglund, L Henry, N Brown, A Billman, C Maloney, P Nallon, E Tidrow, M Pellegrino, J AF Baril, Neil Bandara, Sumith Hoeglund, Linda Henry, Nathan Brown, Alexander Billman, Curtis Maloney, Patrick Nallon, Eric Tidrow, Meimei Pellegrino, Joseph TI Low operating bias InAs/GaSb strain layer superlattice LWIR detector SO INFRARED PHYSICS & TECHNOLOGY LA English DT Article; Proceedings Paper CT 8th International Workshop on Quantum Structure Infrared Photodetectors (QSIP) CY JUN 29-JUL 03, 2014 CL Santa Fe, NM SP Univ New Mexico, Georgia State Univ, NASA Jet Propuls Lab, AF Res Lab, Army Res Off DE Superlattice; Infrared detector; Heterojunction; Band offset; InAs/GaSb; Barrier AB Minimization of operating bias and generation-recombination dark current in long wavelength infrared (LWIR) strained layer superlattice (SLS) detectors, consisting of a lightly doped p-type absorber layer and a wide band gap hole barrier, are investigated with respect to the band alignment between the wide band gap barrier and absorber layers. Dark current vs. bias, photoresponse, quantum efficiency, lifetime, and modeling are used to correlate device performance with the wide gap barrier composition. Decreases in dark current density and operating bias were observed as the conduction band of the wide gap barrier was lowered with respect to the absorber layer. The device achieved 95% of its maximum quantum efficiency at 0 V bias, and 100% by 0.05 V. This study demonstrates key device design parameters responsible for optimal performance of heterojunction based SLS LWIR detectors. Published by Elsevier B.V. C1 [Baril, Neil; Bandara, Sumith; Billman, Curtis; Maloney, Patrick; Nallon, Eric; Tidrow, Meimei; Pellegrino, Joseph] US Army RDECOM CERDEC NVESD, Ft Belvoir, VA 22060 USA. [Hoeglund, Linda] Corbin Co, Alexandria, VA 22314 USA. [Henry, Nathan; Brown, Alexander] CALTECH, Jet Prop Lab, Pasadena, CA 91109 USA. RP Baril, N (reprint author), 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA. EM info@nvl.army.mil NR 8 TC 2 Z9 2 U1 5 U2 19 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1350-4495 EI 1879-0275 J9 INFRARED PHYS TECHN JI Infrared Phys. Technol. PD MAY PY 2015 VL 70 BP 58 EP 61 DI 10.1016/j.infrared.2014.10.013 PG 4 WC Instruments & Instrumentation; Optics; Physics, Applied SC Instruments & Instrumentation; Optics; Physics GA CL8OM UT WOS:000357234000013 ER PT J AU DeCuir, EA Choi, KK Sun, J Wijewarnasuriya, PS AF DeCuir, Eric A., Jr. Choi, Kwong-Kit Sun, Jason Wijewarnasuriya, Priyalal S. TI Progress in resonator quantum well infrared photodetector (R-QWIP) focal plane arrays SO INFRARED PHYSICS & TECHNOLOGY LA English DT Article; Proceedings Paper CT 8th International Workshop on Quantum Structure Infrared Photodetectors (QSIP) CY JUN 29-JUL 03, 2014 CL Santa Fe, NM SP Univ New Mexico, Georgia State Univ, NASA Jet Propuls Lab, AF Res Lab, Army Res Off DE Resonantor quantum well infrared photodector (R-QWIP); Focal plane array (FPA); Conversion efficiency (CE); Quantum efficiency; Noise Equivalent Temperature Difference (NEdT); Dark current ID SUPERLATTICE AB In this work, the performance of a 640 x 512 long-wavelength resonant quantum well infrared photodetector (R-QWIP) focal plane array (FPA) was evaluated as a function of operating temperature, bias, and photon flux using an F/2.2 optic. From these FPA measurements an assessment of the dark current, noise, conversion efficiency and noise-equivalent temperature difference is provided herein. Histogram results are used to support a statistical interpretation of operability and non-uniformity across the R-QWIP FPA. In addition, single pixel devices fabricated from the same wafer lot enabled supplemental noise gain and spectral response measurements. The spectral response of this R-QWIP structure was confirmed to peak around 8.3 microns with a spectral bandwidth or approximately 1 micron (full-width half maximum) and the noise gain measurements were used to provide an estimation of the expected external quantum efficiency (conversion efficiency = quantum efficiency * gain). Published by Elsevier B.V. C1 [DeCuir, Eric A., Jr.; Choi, Kwong-Kit; Sun, Jason; Wijewarnasuriya, Priyalal S.] US Army, Res Lab, Adelphi, MD 20783 USA. RP DeCuir, EA (reprint author), US Army, Res Lab, RDRL SEE 1,2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM eric.a.decuir.civ@mail.mil NR 10 TC 1 Z9 1 U1 2 U2 11 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1350-4495 EI 1879-0275 J9 INFRARED PHYS TECHN JI Infrared Phys. Technol. PD MAY PY 2015 VL 70 BP 138 EP 146 DI 10.1016/j.infrared.2014.09.018 PG 9 WC Instruments & Instrumentation; Optics; Physics, Applied SC Instruments & Instrumentation; Optics; Physics GA CL8OM UT WOS:000357234000030 ER PT J AU Choi, KK Sun, J DeCuir, EA Olver, KA Wijewarnasuriya, P AF Choi, K. K. Sun, J. DeCuir, E. A. Olver, K. A. Wijewarnasuriya, P. TI Electromagnetic modeling and resonant detectors and arrays SO INFRARED PHYSICS & TECHNOLOGY LA English DT Article; Proceedings Paper CT 8th International Workshop on Quantum Structure Infrared Photodetectors (QSIP) CY JUN 29-JUL 03, 2014 CL Santa Fe, NM SP Univ New Mexico, Georgia State Univ, NASA Jet Propuls Lab, AF Res Lab, Army Res Off DE QWIP; Resonance; FPA; Electromagnetic modeling; Quantum efficiency ID WELL INFRARED PHOTODETECTOR AB We recently developed a finite element three-dimensional electromagnetic model for quantum efficiency (QE) computation. It is applicable to any arbitrary detector geometry and materials. Using this model, we can accurately account for the open literature experimental results that we have investigated, which include those from GaAs solar cells, GaSb type-II superlattices, and GaAs quantum wells. We applied the model to design a photon trap to increase detector QE. By accumulating and storing incident light in the resonator-QWIP structure, we observed experimental QE as high as 71%. This improvement shows that we are now able to fully determine the optical properties of QWIPs. For example, we can design QWIPs to detect at certain wavelengths with certain bandwidths. To illustrate this capability, we designed QWIPs with its QE spectrum matching well with the transmission spectrum of a medium. We subsequently produced several focal plane arrays according to these designs with 640 x 512 and 1 K x 1 K formats. In this paper, we will compare the modeled QE and the experimental results obtained from single detectors as well as FPAs. Published by Elsevier B.V. C1 [Choi, K. K.; Sun, J.; DeCuir, E. A.; Olver, K. A.; Wijewarnasuriya, P.] US Army, Res Lab, Adelphi, MD 20783 USA. RP Choi, KK (reprint author), US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM kwong.k.chol.civ@mail.mil NR 17 TC 1 Z9 1 U1 0 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1350-4495 EI 1879-0275 J9 INFRARED PHYS TECHN JI Infrared Phys. Technol. PD MAY PY 2015 VL 70 BP 153 EP 161 DI 10.1016/j.infrared.2014.09.009 PG 9 WC Instruments & Instrumentation; Optics; Physics, Applied SC Instruments & Instrumentation; Optics; Physics GA CL8OM UT WOS:000357234000032 ER PT J AU Liao, DH AF Liao, DaHan TI Generalized Wideband Harmonic Imaging of Nonlinearly Loaded Scatterers SO IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION LA English DT Article DE Computational electromagnetics; harmonic balance; harmonic imaging; linear and nonlinear electromagnetic scattering; method-of-moments; nonlinear radar ID MOM-AOM APPROACH; FREQUENCY-DOMAIN; ANTENNA-ARRAY; HALF-SPACE; TRANSIENT-RESPONSE; MINE DETECTION; WIRE; DIPOLE; LOSSY; ALGORITHMS AB Wideband electromagnetic sensing and imaging of nonlinearly loaded scatterers is considered. Harmonic scattering theory is first presented, and then a generalized near-field, direct imaging functional is proposed for free-space and near-ground target localization within the context of forward-looking radar standoff detection exploiting sequential single-tone excitation. The developed scattering and imaging analysis framework is illustrated for point-like and extended targets through numerical experiments performed with a hybrid method-of-moments solver, in conjunction with a harmonic balance approach and an asymptotic field propagation technique. The steady-state harmonic scattering responses are examined in the time, frequency, and image domains for scatterers in free-space and half-space environments, and accurate target localization is demonstrated in all cases for each harmonic order considered. C1 US Army Res Lab, Adelphi, MD 20783 USA. RP Liao, DH (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM dahan.liao.civ@mail.mil NR 33 TC 0 Z9 0 U1 2 U2 6 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-926X EI 1558-2221 J9 IEEE T ANTENN PROPAG JI IEEE Trans. Antennas Propag. PD MAY PY 2015 VL 63 IS 5 BP 2079 EP 2087 DI 10.1109/TAP.2015.2405080 PG 9 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA CK8UH UT WOS:000356513700019 ER PT J AU Nuckols, JT Huang, YJS Higgs, S Miller, AL Pyles, RB Spratt, HM Horne, KM Vanlandingham, DL AF Nuckols, J. T. Huang, Y. -J. S. Higgs, S. Miller, A. L. Pyles, R. B. Spratt, H. M. Horne, K. M. Vanlandingham, D. L. TI Evaluation of Simultaneous Transmission of Chikungunya Virus and Dengue Virus Type 2 in Infected Aedes aegypti and Aedes albopictus (Diptera: Culicidae) SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE Aedes aegypti; Aedes albopictus; chikungunya; dengue; transmission ID CONCURRENT ISOLATION; REUNION ISLAND; CENTRAL-AFRICA; SINDBIS VIRUS; INDIAN-OCEAN; INTERFERENCE; ARBOVIRUSES; VECTORS; FEVER; ALPHAVIRUSES AB The simultaneous transmission of chikungunya virus (CHIKV) and dengue viruses (DENV) has been a major public health concern because of their sympatric distribution and shared mosquito vectors. Groups of Aedes aegypti (L.) and Aedes albopictus (Skuse) were orally infected with 1.5 x 10(5) PFU/ml of CHIKV and 3.2 x 10(6) FFU/ml of DENV-2 simultaneously or separately in inverse orders and evaluated for dissemination and transmission by qRT-PCR. Simultaneous dissemination of both viruses was detected for all groups in Ae. aegypti and Ae. albopictus while cotransmission of CHIKV and DENV-2 only occurred at low rates after sequential but not simultaneous infection. C1 [Nuckols, J. T.] US Army, Joint Vaccine Acquisit Program, Med Countermeasure Syst, Ft Detrick, MD 21702 USA. [Huang, Y. -J. S.; Higgs, S.; Horne, K. M.; Vanlandingham, D. L.] Kansas State Univ, Biosecur Res Inst, Manhattan, KS 66506 USA. [Huang, Y. -J. S.; Higgs, S.; Vanlandingham, D. L.] Kansas State Univ, Coll Vet Med, Dept Diagnost Med & Pathobiol, Manhattan, KS 66506 USA. [Miller, A. L.; Pyles, R. B.] Univ Texas Med Branch, Dept Pediat, Galveston, TX 77555 USA. [Miller, A. L.; Pyles, R. B.] Univ Texas Med Branch, Assay Dev Serv Div, Galveston Natl Lab, Galveston, TX 77555 USA. [Spratt, H. M.] Univ Texas Med Branch, Dept Preventat Med & Community Hlth, Galveston, TX 77555 USA. RP Vanlandingham, DL (reprint author), Kansas State Univ, Biosecur Res Inst, 1041 Pat Roberts Hall, Manhattan, KS 66506 USA. EM dlvanlan@bri.ksu.edu FU National Institutes of Health (NIH) [R21 A1073389]; U.S. Army Medical Department's Long Term Healthcare Education and Training program FX We wish to thank Jing Huang for her invaluable knowledge of mosquito manipulation and her persistent efforts to assist in the administration of enemas to the mosquitoes. This work was in part supported by National Institutes of Health (NIH) grant R21 A1073389 (to S.H.) and J.T.N. was supported by the U.S. Army Medical Department's Long Term Healthcare Education and Training program. NR 32 TC 5 Z9 5 U1 4 U2 9 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-2585 EI 1938-2928 J9 J MED ENTOMOL JI J. Med. Entomol. PD MAY PY 2015 VL 52 IS 3 BP 447 EP 451 DI 10.1093/jme/tjv017 PG 5 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA CL1RC UT WOS:000356720600020 PM 26334820 ER PT J AU Gutting, BW Rukhin, A Mackie, RS Marchette, D Thran, B AF Gutting, Bradford W. Rukhin, Andrey Mackie, Ryan S. Marchette, David Thran, Brandolyn TI Evaluation of Inhaled Versus Deposited Dose Using the Exponential Dose-Response Model for Inhalational Anthrax in Nonhuman Primate, Rabbit, and Guinea Pig SO RISK ANALYSIS LA English DT Article DE Acute; anthrax; deposition; dose response; guinea pig; inhalation; nonhuman primate; rabbit; risk assessment ID AFRICAN-GREEN MONKEY; BACILLUS-ANTHRACIS; INCUBATION PERIOD; PATHOLOGY; RISK; INFECTION; SPORES; AEROSOL; OUTBREAK; MACROPHAGES AB The application of the exponential model is extended by the inclusion of new nonhuman primate (NHP), rabbit, and guinea pig dose-lethality data for inhalation anthrax. Because deposition is a critical step in the initiation of inhalation anthrax, inhaled doses may not provide the most accurate cross-species comparison. For this reason, species-specific deposition factors were derived to translate inhaled dose to deposited dose. Four NHP, three rabbit, and two guinea pig data sets were utilized. Results from species-specific pooling analysis suggested all four NHP data sets could be pooled into a single NHP data set, which was also true for the rabbit and guinea pig data sets. The three species-specific pooled data sets could not be combined into a single generic mammalian data set. For inhaled dose, NHPs were the most sensitive (relative lowest LD50) species and rabbits the least. Improved inhaled LD(50)s proposed for use in risk assessment are 50,600, 102,600, and 70,800 inhaled spores for NHP, rabbit, and guinea pig, respectively. Lung deposition factors were estimated for each species using published deposition data from Bacillus spore exposures, particle deposition studies, and computer modeling. Deposition was estimated at 22%, 9%, and 30% of the inhaled dose for NHP, rabbit, and guinea pig, respectively. When the inhaled dose was adjusted to reflect deposited dose, the rabbit animal model appears the most sensitive with the guinea pig the least sensitive species. C1 [Gutting, Bradford W.; Mackie, Ryan S.] Naval Surface Warfare Ctr, Dahlgren Div, CBR Concepts & Experimentat Branch Z21, Dahlgren, VA USA. [Rukhin, Andrey; Marchette, David] Naval Surface Warfare Ctr, Dahlgren Div, Sensor Fus Branch Q33, Dahlgren, VA USA. [Thran, Brandolyn] US Army Publ Hlth Command, Aberdeen Proving Ground, MD 21010 USA. RP Thran, B (reprint author), US Army Publ Hlth Command, Aberdeen Proving Ground, MD 21010 USA. EM brandolyn.h.thran2.civ@mail.mil NR 71 TC 3 Z9 3 U1 1 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0272-4332 EI 1539-6924 J9 RISK ANAL JI Risk Anal. PD MAY PY 2015 VL 35 IS 5 BP 811 EP 827 DI 10.1111/risa.12326 PG 17 WC Public, Environmental & Occupational Health; Mathematics, Interdisciplinary Applications; Social Sciences, Mathematical Methods SC Public, Environmental & Occupational Health; Mathematics; Mathematical Methods In Social Sciences GA CL1MF UT WOS:000356706800005 PM 25545587 ER PT J AU Dagefu, FT Choi, JH Sheikhsofla, M Sadler, BM Sarabandi, K AF Dagefu, Fikadu T. Choi, Jihun Sheikhsofla, Morteza Sadler, Brian M. Sarabandi, Kamal TI Performance assessment of lower VHF band for short-range communication and geolocation applications SO RADIO SCIENCE LA English DT Article DE lower VHF band; wave propagation; measurements; channel characterization; wireless communication; near-ground propagation ID WAVE-PROPAGATION; LOW-PROFILE; WALLS AB The focus of this paper is to characterize near-ground wave propagation in the lower very high frequency (VHF) band and to assess advantages that this frequency band offers for reliable short-range low-data rate communications and geolocation applications in highly cluttered environments as compared to conventional systems in the microwave range. With the advent of palm-sized miniaturized VHF antennas, interest in low-power and low-frequency communication links is increasing because (1) channel complexity is far less in this frequency band compared to higher frequencies and (2) significant signal penetration through/over obstacles is possible at this frequency. In this paper, we quantify the excess path loss and small-scale fading at the lower VHF and the 2.4GHz bands based on short-range measurements in various environments. We consider indoor-to-indoor, outdoor-to-indoor, and non-line-of-sight outdoor measurements and compare the results with measurements at higher frequencies which are used in conventional systems (i.e., 2.4GHz). Propagation measurements at the lower VHF band are carried out by using an electrically small antenna to assess the possibility of achieving a miniaturized, mobile system for near-ground communication. For each measurement scenario considered, path loss and small-scale fading are characterized after calibrating the differences in the systems used for measurements at different frequencies, including variations in antenna performance. C1 [Dagefu, Fikadu T.; Sadler, Brian M.] US Army Res Lab, Adelphi, MD 20783 USA. [Choi, Jihun; Sheikhsofla, Morteza; Sarabandi, Kamal] Univ Michigan, Dept Elect Engn & Comp Sci, Ann Arbor, MI 48109 USA. RP Dagefu, FT (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM DFikadu@gmail.com FU National Science Foundation, ECE Program [1101868]; U.S. Army Research Laboratory [W911NF-08-2-0004] FX The data for this paper can be requested by sending an email to Fikadu Dagefu at fikadu.t.dagefu.ctr@mail.mil. This research was supported in part by National Science Foundation, ECE Program, under Award Number: 1101868 and by the U.S. Army Research Laboratory under contract W911NF-08-2-0004 and prepared through collaborative participation in the Microelectronics Center of Micro Autonomous Systems and Technology (MAST) Collaborative Technology Alliance (CTA). NR 17 TC 5 Z9 5 U1 1 U2 3 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0048-6604 EI 1944-799X J9 RADIO SCI JI Radio Sci. PD MAY PY 2015 VL 50 IS 5 BP 443 EP 452 DI 10.1002/2014RS005601 PG 10 WC Astronomy & Astrophysics; Geochemistry & Geophysics; Meteorology & Atmospheric Sciences; Remote Sensing; Telecommunications SC Astronomy & Astrophysics; Geochemistry & Geophysics; Meteorology & Atmospheric Sciences; Remote Sensing; Telecommunications GA CK8MT UT WOS:000356493000008 ER PT J AU McNutt, PM Beske, PH Bradford, AB Hubbard, KS Lyman, ME AF McNutt, P. M. Beske, P. H. Bradford, A. B. Hubbard, K. S. Lyman, M. E. TI Detection and Therapeutic Screening of Clostridial Neurotoxins Using Networked Cultures of Stem Cell-derived Neurons: Good Neurons Make Good Science SO IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL LA English DT Meeting Abstract C1 [McNutt, P. M.; Beske, P. H.; Bradford, A. B.; Hubbard, K. S.; Lyman, M. E.] US Army, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. EM patrick.m.mcnutt2.civ@mail.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1071-2690 EI 1543-706X J9 IN VITRO CELL DEV-AN JI In Vitro Cell. Dev. Biol.-Anim. PD MAY PY 2015 VL 51 SU 1 MA A-1008 BP S29 EP S29 PG 1 WC Cell Biology; Developmental Biology SC Cell Biology; Developmental Biology GA CJ6HF UT WOS:000355594000069 ER PT J AU Mondy, L Mrozek, R Rao, R Lenhart, J Bieg, L Spangler, S Stavig, M Schroeder, J Winter, M Diantonio, C Collins, R AF Mondy, L. Mrozek, R. Rao, R. Lenhart, J. Bieg, L. Spangler, S. Stavig, M. Schroeder, J. Winter, M. Diantonio, C. Collins, R. TI Multilayer Coextrusion of Polymer Composites to Develop Organic Capacitors SO INTERNATIONAL POLYMER PROCESSING LA English DT Article ID MOLTEN POLYMERS; FLOW; CONDUCTIVITY; INSTABILITIES; SUSPENSIONS; STABILITY; EXTRUSION; MECHANISM; VISCOSITY; LAYERS AB Multilayer coextrusion is applied to produce a tape containing layers of alternating electrical properties to demonstrate the potential for using coextrusion to manufacture capacitors. To obtain the desired properties, we develop two filled polymer systems, one for conductive layers and one for dielectric layers. We describe numerical models used to help determine the material and processing parameters that impact processing and layer stability. These models help quantify the critical ratios of densities and viscosities of the two layers to maintain stable layers, as well as the effect of increasing the flow rate of one of the two materials. The conducting polymer is based on polystyrene filled with a blend of low-melting-point eutectic metal and nickel particulate filler, as described by Mrozek et al. (2010). The appropriate concentrations of fillers are determined by balancing measured conductivity with processability in a twin screw extruder. Based on results of the numerical models and estimates of the viscosity of emulsions and suspensions, a dielectric layer composed of polystyrene filled with barium titanate is formulated. Despite the fact that the density of the dielectric filler is less than the metallic filler of the conductive phase, as well as rheological measurements that later showed that the dielectric formulation is not an ideal match to the viscosity of the conductive material, the two materials can be successfully coextruded if the flow rates of the two materials are not identical. A measurable capacitance of the layered structure is obtained. C1 [Mondy, L.; Rao, R.; Bieg, L.; Spangler, S.; Stavig, M.; Schroeder, J.; Winter, M.; Diantonio, C.; Collins, R.] Sandia Natl Labs, Albuquerque, NM 87122 USA. [Mrozek, R.; Lenhart, J.] US Army Res Lab, Aberdeen, MD USA. RP Mondy, L (reprint author), Sandia Natl Labs, Albuquerque, NM 87122 USA. EM lamondy@sandia.gov FU Laboratory Directed Research and Development program at Sandia National Laboratories; U.S. Department of Energy's National Nuclear Security Administration [DE-AC04-94AL85000] FX Thanks go to Adam Lester for dielectric measurements. Phil Cole and his graduate work at the University of Minnesota were the inspiration for the project. Thanks to Randy Schunk, Chris Pommer, Eric Vandre, Larry Musson and Scott Roberts for useful discussions on linear stability analysis. This work was supported by the Laboratory Directed Research and Development program at Sandia National Laboratories. Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000. NR 48 TC 0 Z9 0 U1 1 U2 18 PU CARL HANSER VERLAG PI MUNICH PA KOLBERGERSTRASSE 22, POSTFACH 86 04 20, D-81679 MUNICH, GERMANY SN 0930-777X J9 INT POLYM PROC JI Int. Polym. Process. PD MAY PY 2015 VL 30 IS 2 BP 182 EP 193 DI 10.3139/217.2872 PG 12 WC Engineering, Chemical; Polymer Science SC Engineering; Polymer Science GA CK0XR UT WOS:000355929500001 ER PT J AU Vasterling, JJ Proctor, SP Aslan, M Ko, J Jakupcak, M Harte, CB Marx, BP Concato, J AF Vasterling, Jennifer J. Proctor, Susan P. Aslan, Mihaela Ko, John Jakupcak, Matthew Harte, Christopher B. Marx, Brian P. Concato, John TI Military, Demographic, and Psychosocial Predictors of Military Retention in Enlisted Army Soldiers 12 Months After Deployment to Iraq SO MILITARY MEDICINE LA English DT Article ID NATIONAL-GUARD SOLDIERS; HEALTH-CARE UTILIZATION; TRAUMATIC BRAIN-INJURY; MENTAL-HEALTH; US MILITARY; PTSD SYMPTOMS; UNIT COHESION; ATTRITION; AFGHANISTAN; VETERANS AB Objective: To examine military, demographic, and psychosocial predictors of military retention following operational deployment. Methods: Military status 12 months following return from Iraq deployment was assessed via service records in 740 regular active duty Army Soldiers. Potential predictors of military retention were derived from prospectively administered in-person interviews and questionnaires conducted within 3 months following return from Iraq. Results: At 12 months following return from deployment, 18.1% (n = 134) of the sample had separated from military service. Cox proportional hazards analyses, adjusting for demographic, military, and psychosocial predictors, identified several factors that were independently associated with military attrition: less than (vs. equal to or more than) 6 years military experience (hazards ratio [HR], 3.98; 95% CI, 2.12-7.45); unmarried (vs. married) status (HR, 1.51; 95% CI, 1.06-2.16); and lower (vs. higher) levels of self-reported unit support during deployment (HR, 2.22; 95% CI, 1.42-3.47). Conclusions: Service members early in their career may be especially prone to military attrition. With regard to military retention, our findings suggest that it may be particularly important to develop initiatives that target organizational cohesion and support. C1 [Vasterling, Jennifer J.; Harte, Christopher B.; Marx, Brian P.] VA Boston Healthcare Syst, Natl Ctr PTSD & Psychol, Boston, MA 02130 USA. [Vasterling, Jennifer J.; Harte, Christopher B.; Marx, Brian P.] Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02118 USA. [Proctor, Susan P.] US Army Res Inst Environm Med, Natick, MA 01760 USA. [Proctor, Susan P.] VA Boston Healthcare Syst, Res Serv, Boston, MA 02130 USA. [Proctor, Susan P.] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02118 USA. [Aslan, Mihaela; Ko, John; Concato, John] VA Connecticut Healthcare Syst, Clin Epidemiol Res Ctr, West Haven, CT 06516 USA. [Aslan, Mihaela] Yale Univ, Sch Med, Dept Med, New Haven, CT 06510 USA. [Jakupcak, Matthew] VA Puget Sound Healthcare Syst, Seattle, WA 98108 USA. [Jakupcak, Matthew] Univ Washington, Sch Med, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA. RP Vasterling, JJ (reprint author), VA Boston Healthcare Syst, Natl Ctr PTSD & Psychol, 150 South Huntington Ave, Boston, MA 02130 USA. FU U.S. Army Medical Research and Materiel Command [DAMD 17-03-0020]; Department of Veterans Affairs Clinical Sciences Research and Development; Clinical Epidemiology Research Center, VA Cooperative Studies Program FX We appreciate the support of the Defense Manpower Data Center in obtaining military service status data. We are also grateful to the Soldiers who comprise the Neurocognition Deployment Health Study cohort for volunteering their time to participate in the study and for their military service more generally. Funding for the collection of primary assessment data was provided by the U.S. Army Medical Research and Materiel Command (DAMD 17-03-0020) and the Department of Veterans Affairs Clinical Sciences Research and Development. Data analyses and collection of secondary data from military administrative records were supported by the Clinical Epidemiology Research Center, VA Cooperative Studies Program. The primary funding organizations had no role in the scientific aspects of the study or the preparation of the manuscript. The manuscript underwent scientific and administrative review within the U.S. Army Research Institute for Environmental Medicine. NR 29 TC 2 Z9 2 U1 1 U2 6 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAY PY 2015 VL 180 IS 5 BP 524 EP 532 DI 10.7205/MILMED-D-14-00468 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA CJ5WF UT WOS:000355562600016 PM 25939106 ER PT J AU Sepowitz, JJ Fauser, KR Meyer, SA Jackson, SJ AF Sepowitz, John J. Fauser, Kristina R. Meyer, Stephanie A. Jackson, Steven J. TI Supplemental Genistein, Quercetin, and Resveratrol Intake in Active Duty Army Soldiers SO MILITARY MEDICINE LA English DT Article ID BREAST-CANCER CELLS; PHASE-II TRIAL; PROSTATE-CANCER; DIETARY-SUPPLEMENTS; BONE LOSS; ISOFLAVONE SUPPLEMENTATION; PHYTOESTROGEN GENISTEIN; SOY ISOFLAVONES; UNITED-STATES; WOMEN AB Previous reports indicate that the majority of U.S. Army soldiers consume dietary supplements (DSs) > 1 time/wk. However, these studies did not evaluate phytonutrient supplementation. A growing literature suggests inclusion of phytonutrients in DSs may pose a risk for toxicity, which could impact the performance of soldier duties, as well as long-term health and wellness. This study was conducted to assess and understand soldiers' motivations to consume phytonutrient-containing DSs, specifically genistein, quercetin, and resveratrol. The study was a cross-sectional, descriptive mixed-methods design using a survey and semistructured interviews. There were 436 soldiers stationed at Joint Base Lewis-McChord, Washington who completed the survey, from which 36 soldiers completed an interview. Overall, 34% of soldiers reported taking a single or multicomponent phytonutrient DS > 1 time/wk, from which 41 soldiers took > 1 supplement/wk. Soldiers' reasons for use included unsure (54%), weight loss (12%), and other, unspecified (24%). The majority of interviewees did not consume DSs based on inclusion of genistein, quercetin, or resveratrol. The majority of soldiers, in our study, appear unable to rationalize their phytonutrient DS choices. Findings from this study illuminate the need for future research to further explore DS practices within military populations and encourage informed use of DSs. C1 [Sepowitz, John J.] US Army Res Inst Environm Med, Natick, MA 01760 USA. [Fauser, Kristina R.] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA 30305 USA. [Meyer, Stephanie A.] Madigan Army Med Ctr, Tacoma, WA 98431 USA. [Jackson, Steven J.] US Army Aeromed Res Lab, Ft Rucker, AL 36362 USA. RP Sepowitz, JJ (reprint author), US Army Res Inst Environm Med, Bldg 42,Kansas St, Natick, MA 01760 USA. NR 49 TC 0 Z9 0 U1 0 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAY PY 2015 VL 180 IS 5 BP 547 EP 553 DI 10.7205/MILMED-D-14-00514 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA CJ5WF UT WOS:000355562600019 PM 25939109 ER PT J AU Wojcik, BE Szeszel-Fedorowicz, W Humphrey, RJ Colthirst, P Guerrero, AC Simecek, JW Fedorowicz, A Eikenberg, S Rogers, GG DeNicolo, P AF Wojcik, Barbara E. Szeszel-Fedorowicz, Wioletta Humphrey, Rebecca J. Colthirst, Paul Guerrero, Alicia C. Simecek, John W. Fedorowicz, Adam Eikenberg, Steven Rogers, Georgia G. DeNicolo, Philip TI Risk of Dental Disease Non-Battle Injuries and Severity of Dental Disease in Deployed US Army Personnel SO MILITARY MEDICINE LA English DT Article ID EMERGENCY RATES; NONBATTLE INJURY; BOSNIA; FREEDOM; IRAQ AB Dental Disease and Non-Battle Injuries (D-DNBI) continue to be a problem among U.S. Army active duty (AD), U.S. Army National Guard (ARNG), and U.S. Army Reserve (USAR) deployed soldiers to Operation Iraqi Freedom/Operation New Dawn in Iraq and Operation Enduring Freedom in Afghanistan. A previous study reported the annual rates to be 136 D-DNBI per 1,000 personnel for AD, 152 for ARNG, and 184 for USAR. The objectives of this study were to describe D-DNBI incidence and to determine risk factors for dental encounters and high severity diagnoses for deployed soldiers. The 78 diagnoses were classified into three categories based on severity. Poisson regression was used to compare D-DNBI rates and logistic regression was used to analyze the risk of high severity D-DNBI. In both campaigns, Reserve had a higher risk of D-DNBI than active duty. For Afghanistan, ARNG and USAR demonstrated over 50% increased risk of D-DNBI compared to AD. In Iraq, USAR had a 17% increased risk over AD. Females had a higher risk of D-DNBI (>50%) compared to males in both campaigns. High severity D-DNBI made up 2.77% of all diagnoses. Within Afghanistan, there was a 4.6% increased risk of high severity D-DNBI for each additional deployment month. C1 [Wojcik, Barbara E.; Szeszel-Fedorowicz, Wioletta; Humphrey, Rebecca J.; Colthirst, Paul; Guerrero, Alicia C.; Fedorowicz, Adam] Ctr AMEDD Strateg Studies, ATTN MCCS FH, Ft Sam Houston, TX 78234 USA. [Colthirst, Paul] Triserv Ctr Oral Hlth Studies, Ft Sam Houston, TX 78234 USA. [Simecek, John W.] Naval Med Res Unit San Antonio, Ft Sam Houston, TX 78234 USA. [Eikenberg, Steven] Army Med Dept AMEDD Ctr & Sch, Ft Sam Houston, TX 78234 USA. [Rogers, Georgia G.] Aberdeen Proving Ground Dent Clin Command, Aberdeen Proving Ground, MD 21005 USA. [DeNicolo, Philip] US Army, Inst Surg Res, Dent Trauma Res Detachment, Ft Sam Houston, TX 78234 USA. RP Wojcik, BE (reprint author), Ctr AMEDD Strateg Studies, ATTN MCCS FH, 2478 Stanley Rd,Suite 47, Ft Sam Houston, TX 78234 USA. NR 22 TC 0 Z9 0 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAY PY 2015 VL 180 IS 5 BP 570 EP 577 DI 10.7205/MILMED-D-14-00364 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA CJ5WF UT WOS:000355562600023 PM 25939113 ER PT J AU Peck, GW Helgeson, SM Powell, ED Roth, AL Flores, M Kirkup, BC AF Peck, George W. Helgeson, Sandra M. Powell, Eric D. Roth, Amanda L. Flores, Micah Kirkup, Benjamin C., Jr. TI Airworthiness Testing of Medical Maggots SO MILITARY MEDICINE LA English DT Article ID LUCILIA-SERICATA DIPTERA; INJURIES 2011 UPDATE; DEBRIDEMENT THERAPY; MEDICINAL MAGGOTS; CHRONIC WOUNDS; CALLIPHORIDAE; PREVENTION; GUIDELINES; LARVAE; RATES AB An investigation was conducted to test and certify medicinal maggots to facilitate rapid healing of traumatic and chronic wound infections in Wounded warriors being transported onboard military aircraft. Our specific aims included (1) to test the ability of medical grade larvae to withstand the rigors of U.S. Army aeromedical certification, including tolerance to change in pressure, temperature, and humidity inside ground-based chambers; (2) to evaluate the efficacy of the medical grade larvae during a high-vibration rotary-wing medical transport flight; and (3) to gain U.S. Army aeromedical certification and U.S. Air Force safe-to-fly approval and begin the steps needed to deploy/implement the use of medicinal maggots in patient care regimes for medical airlift standard operating procedures. This report outlines the ground-based and initial air-based tests performed during the study. Maggot mortality was very low during all tests, with a mortality rate of less than 1%. Maggot growth rates in wound arenas were mixed but generally depended on temperature. Overall, the results of these tests suggest that medicinal maggots can withstand the rigors of aeromedical evacuation flights in simulated flight environments and rotary-or fixed-wing aircraft. C1 [Peck, George W.] Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD 20910 USA. [Helgeson, Sandra M.] US Army Aeromed Res Lab, Airworthiness Certificat & Evaluat Branch, Ft Rucker, AL 36362 USA. [Powell, Eric D.] US Air Force Sch Aerosp Med, Dept Aeromed Res, Wright Patterson AFB, OH 45433 USA. [Roth, Amanda L.; Flores, Micah] Walter Reed Army Inst Res, Bacterial Dis Branch, Silver Spring, MD 20910 USA. [Kirkup, Benjamin C., Jr.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Med, Bethesda, MD 20814 USA. RP Peck, GW (reprint author), Walter Reed Army Inst Res, Entomol Branch, 503 Robert Grant Ave,Bldg 503,Room 3w81, Silver Spring, MD 20910 USA. RI Kirkup, Benjamin/C-3610-2009 OI Kirkup, Benjamin/0000-0002-8722-6218 FU Defense Medical Research and Development Program (DMRDP), DHP 6.7-Medical Products and Capabilities Enhancements Airworthiness Testing of Medical Maggots [2011053] FX The authors would like to thank the Airworthiness Certification and Evaluation Branch of USAARL for their test guidance, airworthiness testing, and data reporting. This study was funded by Defense Medical Research and Development Program (DMRDP), DHP 6.7-Medical Products and Capabilities Enhancements No. 2011053 Airworthiness Testing of Medical Maggots. NR 27 TC 1 Z9 1 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAY PY 2015 VL 180 IS 5 BP 591 EP 596 DI 10.7205/MILMED-D-14-00548 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA CJ5WF UT WOS:000355562600026 PM 25939116 ER PT J AU Kim, AL AF Kim, Amy Leonard TI Portable Traumatic Brain Injury Detection With Near-Infrared Technology: Infrascanner Model 2000 SO MILITARY MEDICINE LA English DT Editorial Material C1 US Army Med Res & Mat Command, Natl Museum Hlth & Med, Silver Spring, MD 20910 USA. RP Kim, AL (reprint author), US Army Med Res & Mat Command, Natl Museum Hlth & Med, 2500 Linden Lane, Silver Spring, MD 20910 USA. NR 2 TC 0 Z9 0 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAY PY 2015 VL 180 IS 5 BP 597 EP 598 DI 10.7205/MILMED-D-14-00670 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA CJ5WF UT WOS:000355562600027 PM 25939117 ER PT J AU McNaught, MJ Turella, SJ Fallah, DM Demsar, WJ AF McNaught, Michael J. Turella, Stephen J. Fallah, David M. Demsar, William J. TI Spindle Cell Variant of Ameloblastic Carcinoma: A Case Report and Review of Literature SO MILITARY MEDICINE LA English DT Article ID OF-THE-LITERATURE; MALIGNANT AMELOBLASTOMA; MANDIBULAR AMELOBLASTOMA; PULMONARY METASTASIS AB Ameloblastic carcinoma is a rare and malignant odontogenic tumor. Approximately, 100 cases of ameloblastic carcinomas have been reported in the literature, with fewer than 10 reported cases of an even more rare variant with spindle-cell differentiation. Although it is presumed that most ameloblastic carcinomas arise de novo, it also appears capable of proliferating as carcinoma ex ameloblastoma. Without a full past history, the exact origin of these tumors can be unclear. The exact classification becomes further questionable when both an intraosseous and peripheral tumor exists. This currently reported case has been present for at least 4 years before the patient presenting for care. However, without prior biopsy, the etiology and category of this ameloblastic carcinoma is speculative. Our case represents a histologically unequivocal case of ameloblastic carcinoma. Based on tumor morphology, questions still remain, as to whether it arose de novo, or as carcinoma ex ameloblastoma. The possibility of categorizing the current lesion as a spindle cell variant also exists because of the presence of a prominent population of malignant epithelial spindled cells arranged in fascicles. The authors believe that this ameloblastic carcinoma would best be subclassified as a rare spindle cell variant, based on the prominent spindle cell component. C1 [McNaught, Michael J.] 35th & Desert Storm, Kuhn Dent Clin, Ft Campbell, KY 42223 USA. [Turella, Stephen J.; Fallah, David M.] William Beaumont Army Med Ctr, Oral & Maxillofacial Surg Dept, El Paso, TX 79920 USA. [Demsar, William J.] Dwight D Eisenhower Army Med Ctr, Hosp Dent Clin, Ft Gordon, GA 30905 USA. [Demsar, William J.] Dwight D Eisenhower Army Med Ctr, Dept Oral & Maxillofacial Surg, Ft Gordon, GA 30905 USA. RP McNaught, MJ (reprint author), 35th & Desert Storm, Kuhn Dent Clin, Ft Campbell, KY 42223 USA. NR 14 TC 1 Z9 1 U1 0 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAY PY 2015 VL 180 IS 5 BP E614 EP E617 DI 10.7205/MILMED-D-14-00509 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA CJ5WF UT WOS:000355562600005 PM 25939122 ER PT J AU Msonda, HT Laczek, JT AF Msonda, Hapu T. Laczek, Jeffrey T. TI Medical Evacuation for Unrecognized Abdominal Wall Pain: A Case Series SO MILITARY MEDICINE LA English DT Article ID DIAGNOSIS AB Background: Chronic abdominal pain is a frequently encountered complaint in the primary care setting. The abdominal wall is the etiology of this pain in 10 to 30% of all cases of chronic abdominal pain. Abdominal cutaneous nerve entrapment at the lateral border of the rectus abdominis muscle has been attributed as a cause of this pain. In the military health care system, patients with unexplained abdominal pain are often transferred to military treatment facilities via the Military Medical Evacuation (MEDEVAC) system. Case series: We present two cases of patients who transferred via MEDEVAC to our facility for evaluation and treatment of chronic abdominal pain. Both patients had previously undergone extensive laboratory evaluation, imaging, and invasive procedures, such as esophagogastroduodenoscopy before transfer. Upon arrival, history and physical examinations suggested an abdominal wall source to their pain, and both patients experienced alleviation of their abdominal wall pain with lidocaine and corticosteroid injection. Conclusion: This case series highlights the need for military physicians to be aware of abdominal wall pain. Early diagnosis of abdominal cutaneous nerve entrapment syndrome by eliciting Carnett's sign will limit symptom chronicity, avoid unnecessary testing, and even prevent medical evacuation. C1 [Msonda, Hapu T.] Tripler Army Med Ctr, Dept Med, Honolulu, HI 96859 USA. [Laczek, Jeffrey T.] Walter Reed Natl Mil Med Ctr, Dept Med, Gastroenterol Serv, Bethesda, MD 20889 USA. RP Msonda, HT (reprint author), Tripler Army Med Ctr, Dept Med, 1 Jarrett White Rd, Honolulu, HI 96859 USA. NR 11 TC 0 Z9 0 U1 1 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAY PY 2015 VL 180 IS 5 BP E605 EP E607 DI 10.7205/MILMED-D-14-00487 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA CJ5WF UT WOS:000355562600002 PM 25939119 ER PT J AU Mulder, CJ Cho, RS Harrison, SA Cebe, K Francis, JM AF Mulder, Christopher J. Cho, Ryan S. Harrison, Stephen A. Cebe, Katherine Francis, James M. TI Syphilitic Hepatitis Uncommon Presentation of an Old Scourge SO MILITARY MEDICINE LA English DT Article ID GIANT-CELL HEPATITIS AB Background: Giant cell hepatitis is a rare entity in adults, accounting for 0.1% to 0.25% of liver disease in adults. Postinfantile giant cell hepatitis is often characterized by multinucleated giant cells on liver biopsy and a fulminant hepatitis. Case Report: An active duty 36-year-old African-American male deployed to Kabul, Afghanistan, presented with jaundice 2 weeks after starting a testosterone analogue. He discontinued the supplement, but his jaundice persisted with up-trending bilirubin. Serologic testing was negative for hepatitis A, B, C, and E; cytomegalovirus; Epstein-Barr virus; herpes simplex virus; and human immunodeficiency virus. Evaluation for autoimmune hepatitis was negative. Magnetic resonance cholangiopancreatography was negative for obstruction. Liver biopsy revealed giant cell transformation of numerous hepatocytes and cholestatic hepatitis. Rapid plasma reagin was positive without physical findings. Treponema pallidum hemagglutination assays confirmed the diagnosis of latent syphilis. He was started on penicillin treatment with rapid improvement of bilirubin, creatinine, and hepatic synthetic function, all of which eventually normalized. Conclusion: Postinfantile giant cell hepatitis is a severe form of hepatitis that has several different potential etiologies, 2 of which were present in this patient: androgenic supplements and infection. This case highlights syphilis as an unusual but treatable cause of giant cell hepatitis. Testing for syphilis should be considered in any persistent liver injury. C1 [Mulder, Christopher J.; Harrison, Stephen A.; Francis, James M.] Brooke Army Med Ctr, Dept Gastroenterol, Ft Sam Houston, TX 78234 USA. [Cho, Ryan S.] Brooke Army Med Ctr, Dept Internal Med, Ft Sam Houston, TX 78234 USA. [Cebe, Katherine] Brooke Army Med Ctr, Dept Pathol, Ft Sam Houston, TX 78234 USA. RP Mulder, CJ (reprint author), Brooke Army Med Ctr, Dept Gastroenterol, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 16 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAY PY 2015 VL 180 IS 5 BP E611 EP E613 DI 10.7205/MILMED-D-14-00530 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA CJ5WF UT WOS:000355562600004 PM 25939121 ER PT J AU Mulvaney, SW Lynch, JH de Leeuw, J Schroeder, M Kane, S AF Mulvaney, Sean W. Lynch, James H. de Leeuw, Jason Schroeder, Matthew Kane, Shawn TI Neurocognitive Performance is Not Degraded After Stellate Ganglion Block Treatment for Post-Traumatic Stress Disorder: A Case Series SO MILITARY MEDICINE LA English DT Article ID PSYCHOMETRIC PROPERTIES; PTSD CHECKLIST; SPORT; EXPERTISE; MILITARY; COMBAT; SKILLS AB Objective: To measure key neurocognitive performance effects following stellate ganglion block (SGB) administered to treat post-traumatic stress disorder (PTSD) symptoms. Methods: Eleven patients diagnosed, screened, and scheduled for SGB to treat their PTSD symptoms were administered a panel of eight cognitive measures before and 1 to 3 weeks after undergoing this procedure. PTSD symptoms were evaluated using the Posttraumatic Stress Disorder Checklist-Military. Results: One to three weeks post-SGB, none of the patients showed any statistically significant decline in neurocognitive performance. Rather, there was a clear trend in improvement, with four out of eight measures reaching statistical significance following SGB. All patients improved in PTSD symptoms with a mean improvement on Posttraumatic Stress Disorder Checklist-Military of 29. Conclusion: In this case series of 11 patients, SGB effectively treated PTSD symptoms and did not impair reaction time, memory, or concentration. Therefore, SGB should be considered as a viable treatment option for personnel with PTSD symptoms who will be placed in demanding conditions such as combat. C1 [Mulvaney, Sean W.] Uniformed Serv Univ Hlth Sci, Consortium Hlth & Mil Performance, Bethesda, MD 20814 USA. [Mulvaney, Sean W.] Walter Reed Natl Mil Med Ctr, Dept Anesthesia, Bethesda, MD 20814 USA. [Lynch, James H.] Stuttgart Army Hlth Clin, APO, AE 09751 USA. [de Leeuw, Jason] 902nd MI Grp, Ft George G Meade, MD 20755 USA. [Schroeder, Matthew] Ft Belvoir Community Hosp, Ft Belvoir, VA 22060 USA. [Kane, Shawn] DCS Surg AOMD, USASOC A, Ft Bragg, NC 28310 USA. RP Mulvaney, SW (reprint author), Uniformed Serv Univ Hlth Sci, Consortium Hlth & Mil Performance, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. NR 23 TC 2 Z9 2 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAY PY 2015 VL 180 IS 5 BP E601 EP E604 DI 10.7205/MILMED-D-14-00504 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA CJ5WF UT WOS:000355562600001 PM 25939118 ER PT J AU DeSpirito, J AF DeSpirito, James TI Turbulence Model Effects on Cold-Gas Lateral Jet Interaction in a Supersonic Crossflow SO JOURNAL OF SPACECRAFT AND ROCKETS LA English DT Article ID SIDE JET AB Computational fluid dynamic predictions of surface pressures resulting from a sonic lateral jet venting into a supersonic crossflow from a cone-cylinder-flare missile are compared to archival wind-tunnel data. Predictions of axial and azimuthal pressure profiles were found to be very dependent on the turbulence model, with some models performing relatively poorly. Menter's baseline model gave very good to excellent predictions and was used to perform additional validations of other flow conditions, jet nozzle configurations, and jet pressure ratios: again with excellent agreement. The study found that, even with the observed variations in surface pressure, the aerodynamic forces and moments produced by the lateral jet interaction were much less sensitive to the turbulence model. However, an estimate of the trajectory and strength of the counter-rotating vortex pair showed that, although there was little effect of the turbulence model on the location of the vortex pair, the induced vorticity varied by over 30%. This difference can be large enough to impact the prediction of the resultant forces and moments if there are fins or other appendages in the wake of the counter-rotating vortex pair. C1 US Army Res Lab, WMRD Flight Sci Branch, RDRL WML E, Aberdeen Proving Ground, MD 21005 USA. RP DeSpirito, J (reprint author), US Army Res Lab, WMRD Flight Sci Branch, RDRL WML E, Aberdeen Proving Ground, MD 21005 USA. FU U.S. Department of Defense (DOD) High Performance Computing Modernization program at the U.S. Army Research Laboratory DOD Supercomputing Resource Center; Technical Cooperation Program under Key Technology Area [2-30] FX This work was supported in part by a grant of high-performance computing time from the U.S. Department of Defense (DOD) High Performance Computing Modernization program at the U.S. Army Research Laboratory DOD Supercomputing Resource Center. This work was performed under the auspices of the Technical Cooperation Program under Key Technology Area 2-30, "Reaction Control Jets for Weapons," led by the author. The author thanks Ross Chaplin, Defence Science Technology Laboratory, and David MacManus and Robert Christie, Cranfield University, for supplying the digitized experimental data. NR 23 TC 0 Z9 0 U1 1 U2 9 PU AMER INST AERONAUTICS ASTRONAUTICS PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0022-4650 EI 1533-6794 J9 J SPACECRAFT ROCKETS JI J. Spacecr. Rockets PD MAY PY 2015 VL 52 IS 3 BP 836 EP 852 DI 10.2514/1.A32974 PG 17 WC Engineering, Aerospace SC Engineering GA CI8DC UT WOS:000354997900018 ER PT J AU Sahu, J Fresconi, F AF Sahu, Jubaraj Fresconi, Frank TI Aeromechanics and Control of Projectile Roll Using Coupled Simulation Techniques SO JOURNAL OF SPACECRAFT AND ROCKETS LA English DT Article ID CANARD-CONTROLLED MISSILE; AUTOPILOT DESIGN; AERODYNAMIC COEFFICIENTS; GUIDED PROJECTILE; LOW-SPEED; GUIDANCE; ATTACK; ANGLE; DYNAMICS; VEHICLES AB This paper describes a computational study to understand the roll behavior of a canard-controlled projectile. Numerical simulations were performed for this projectile with roll control maneuvers using advanced computational fluid dynamics and coupled aerodynamics/rigid-body dynamics techniques. Roll control algorithms were formulated based on aerodynamic model assessment and parameter estimation. Coupled techniques were validated against wind tunnel experiments for roll control maneuvers. Overall, computed roll control results matched well with the wind tunnel data, indicating that the coupled calculations capture the relevant physics observed in the experiment. This study demonstrates that relatively simple aerodynamic models can be used to represent complex aerodynamic phenomena for these configurations at Mach 0.49. Additionally, roll controllers with favorable performance over a wide range of conditions can be designed based on these models of the aeromechanics. C1 [Sahu, Jubaraj; Fresconi, Frank] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Sahu, J (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. NR 49 TC 1 Z9 1 U1 3 U2 13 PU AMER INST AERONAUTICS ASTRONAUTICS PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0022-4650 EI 1533-6794 J9 J SPACECRAFT ROCKETS JI J. Spacecr. Rockets PD MAY PY 2015 VL 52 IS 3 BP 944 EP 957 DI 10.2514/1.A33133 PG 14 WC Engineering, Aerospace SC Engineering GA CI8DC UT WOS:000354997900026 ER PT J AU Smith, SJ Friedrichs, CT AF Smith, S. Jarrell Friedrichs, Carl T. TI Image processing methods for in situ estimation of cohesive sediment floc size, settling velocity, and density SO LIMNOLOGY AND OCEANOGRAPHY-METHODS LA English DT Article ID SUSPENDED PARTICLES; ESTUARY; PLUME; PIV; FLOCCULATION; INSTRUMENT; TURBULENCE; TRANSPORT; BEHAVIOR; INSSEV AB Recent advances in development of in situ video settling columns have significantly contributed toward fine-sediment dynamics research through concurrent measurement of suspended sediment floc size distributions and settling velocities, which together also allow inference of floc density. Along with image resolution and sizing, two additional challenges in video analysis from these devices are the automated tracking of settling particles and accounting for fluid motions within the settling column. A combination of particle tracking velocimetry (PTV) and particle image velocimetry (PIV) image analysis techniques is described, which permits general automation of image analysis collected from video settling columns. In the fixed image plane, large-particle velocities are determined by PTV and small-particle velocities are tracked by PIV and treated as surrogates for fluid velocities. The large-particle settling velocity (relative to the suspending fluid) is determined by the vector difference of the large and small-particle settling velocities. The combined PTV/PIV image analysis approach is demonstrated for video settling column data collected within a dredge plume in Boston Harbor. The automated PTV/PIV approach significantly reduces uncertainties in measured settling velocity and inferred floc density. C1 [Smith, S. Jarrell] US Army Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. [Friedrichs, Carl T.] Virginia Inst Marine Sci, Coll William & Mary, Gloucester Point, VA 23062 USA. RP Smith, SJ (reprint author), US Army Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. EM Jarrell.Smith@erdc.dren.mil FU National Science Foundation Division of Ocean Sciences [OCE-0536572, OCE-1061781] FX The research presented in this article was conducted under the Dredging Operations and Environmental Research (DOER) program, Dredged Material Management Focus Area at the US Army Engineer Research and Development Center. DOER Program Manager is Dr. Todd Bridges. The manuscript was substantially improved by the insightful comments of Dr. Jules Jaffe and two anonymous reviewers. Additional support for Friedrichs's participation in this study was provided by the National Science Foundation Division of Ocean Sciences Grants OCE-0536572 and OCE-1061781. Permission to publish this article was granted by the Office, Chief of Engineers, US Army Corps of Engineers. This article is contribution No. 3204 of the Virginia Institute of Marine Science, College of William and Mary. NR 52 TC 2 Z9 2 U1 10 U2 29 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1541-5856 J9 LIMNOL OCEANOGR-METH JI Limnol. Oceanogr. Meth. PD MAY PY 2015 VL 13 IS 5 BP 250 EP 264 DI 10.1002/lom3.10022 PG 15 WC Limnology; Oceanography SC Marine & Freshwater Biology; Oceanography GA CJ1FF UT WOS:000355227200004 ER PT J AU Yoon, IK Alera, MT Lago, CB Tac-An, IA Villa, D Fernandez, S Thaisomboonsuk, B Klungthong, C Levy, JW Velasco, JM Roque, VG Salje, H Macareo, LR Hermann, LL Nisalak, A Srikiatkhachorn, A AF Yoon, In-Kyu Alera, Maria Theresa Lago, Catherine B. Tac-An, Ilya A. Villa, Daisy Fernandez, Stefan Thaisomboonsuk, Butsaya Klungthong, Chonticha Levy, Jens W. Velasco, John Mark Roque, Vito G., Jr. Salje, Henrik Macareo, Louis R. Hermann, Laura L. Nisalak, Ananda Srikiatkhachorn, Anon TI High Rate of Subclinical Chikungunya Virus Infection and Association of Neutralizing Antibody with Protection in a Prospective Cohort in The Philippines SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID AEDES-AEGYPTI; INDIAN-OCEAN; VACCINE; DENGUE; SEROPREVALENCE; OUTBREAK; FEVER; EPIDEMIC; DISEASE; SPREAD AB Background Chikungunya virus (CHIKV) is a globally re-emerging arbovirus for which previous studies have indicated the majority of infections result in symptomatic febrile illness. We sought to characterize the proportion of subclinical and symptomatic CHIKV infections in a prospective cohort study in a country with known CHIKV circulation. Methods/Findings A prospective longitudinal cohort of subjects >= 6 months old underwent community-based active surveillance for acute febrile illness in Cebu City, Philippines from 2012-13. Subjects with fever history were clinically evaluated at acute, 2, 5, and 8 day visits, and at a 3-week convalescent visit. Blood was collected at the acute and 3-week convalescent visits. Symptomatic CHIKV infections were identified by positive CHIKV PCR in acute blood samples and/or CHIKV IgM/IgG ELISA seroconversion in paired acute/convalescent samples. Enrollment and 12-month blood samples underwent plaque reduction neutralization test (PRNT) using CHIKV attenuated strain 181/clone25. Subclinical CHIKV infections were identified by >= 8-fold rise from a baseline enrollment PRNT titer < 10 without symptomatic infection detected during the intervening surveillance period. Selected CHIKV PCR-positive samples underwent viral isolation and envelope protein-1 gene sequencing. Of 853 subjects who completed all study procedures at 12 months, 19 symptomatic infections (2.19 per 100 person-years) and 87 subclinical infections (10.03 per 100 person-years) occurred. The ratio of subclinical-to-symptomatic infections was 4.6:1 varying with age from 2: 1 in 6 month-5 year olds to 12: 1 in those >50 years old. Baseline CHIKV PRNT titer >= 10 was associated with 100% (95% CI: 46.1, 100.0) protection from symptomatic CHIKV infection. Phylogenetic analysis demonstrated Asian genotype closely related to strains from Asia and the Caribbean. Conclusions Subclinical infections accounted for a majority of total CHIKV infections. A positive baseline CHIKV PRNT titer was associated with protection from symptomatic CHIKV infection. These findings have implications for assessing disease burden, understanding virus transmission, and supporting vaccine development. C1 [Yoon, In-Kyu; Fernandez, Stefan; Thaisomboonsuk, Butsaya; Klungthong, Chonticha; Levy, Jens W.; Macareo, Louis R.; Hermann, Laura L.; Nisalak, Ananda] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Alera, Maria Theresa; Lago, Catherine B.; Velasco, John Mark] Philippines AFRIMS Virol Res Unit, Cebu, Philippines. [Tac-An, Ilya A.; Villa, Daisy] Cebu City Hlth Dept, Cebu, Philippines. [Roque, Vito G., Jr.] Natl Epidemiol Ctr, Dept Hlth, Manila, Philippines. [Salje, Henrik] Johns Hopkins Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA. [Hermann, Laura L.] Univ Toronto, Dept Med, Toronto, ON, Canada. [Srikiatkhachorn, Anon] Univ Massachusetts, Sch Med, Dept Med, Div Infect Dis & Immunol, Worcester, MA USA. RP Yoon, IK (reprint author), Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. EM Yooni@afrims.org OI Salje, Henrik/0000-0003-3626-4254 FU Armed Forces Health Surveillance Center-Global Emerging Infections Surveillance and Response System [P0140 14 AF]; Canadian Institutes of Health Research FX This research was funded by a grant from the Armed Forces Health Surveillance Center-Global Emerging Infections Surveillance and Response System (Grant #P0140 14 AF) and a Canadian Institutes of Health Research Fellowship for LH. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 40 TC 22 Z9 22 U1 2 U2 5 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD MAY PY 2015 VL 9 IS 5 AR e0003764 DI 10.1371/journal.pntd.0003764 PG 14 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA CJ2HA UT WOS:000355303600031 PM 25951202 ER PT J AU Anderson, MK Grier, T Canham-Chervak, M Bushman, TT Jones, BH AF Anderson, M. K. Grier, T. Canham-Chervak, M. Bushman, T. T. Jones, B. H. TI Occupation and other risk factors for injury among enlisted US Army Soldiers SO PUBLIC HEALTH LA English DT Article DE Military; Occupation; Physical demand; Injury ID EXERCISE-RELATED INJURIES; INFANTRY SOLDIERS; PHYSICAL-FITNESS; MUSCULOSKELETAL INJURIES; U.S. ARMY; MEN; SURVEILLANCE; PREVENTION; DISABILITY; OBESITY AB Objective: To investigate injury risk associated with occupation and occupational physical demand levels among U.S. Army Soldiers. Study design: Retrospective cohort study. Methods: Personal characteristics, physical fitness, military occupational specialty (MOS), and injury data were obtained by survey from Soldiers in an Army light infantry brigade (n = 2101). Odds ratios (OR) and 95% confidence intervals (95% CI) from a multivariate analysis assessing injury risk were calculated. Results: Injury incidence for the prior 12 months was 43%. Physical fitness and behavioral factors associated with injury risk included age 21-29 (OR [age 21-29/age <= 20] = 1.37, 95% CI 1.00-1.90), BMI 27.5-29.9 (high-overweight) (OR high-overweight/normal = 1.62, 95% CI 1.20-2.18); BMI > 29.9 (obese) (OR obese/normal = 1.73, 95% CI 1.23-2.44), cigarette smoking (OR Smoker/Nonsmoker = 1.34, 95% CI 1.11-1.63), and poor APFT two mile run performance (OR (Q4/Q1) = 1.61, 95% CI 1.19-2.19). Higher risk of injury was associated with some MOSs (OR (Chemical, Explosives & Ammunition/Infantry) = 2.82, 95% CI 1.19-6.68; OR (Armor/Infantry) = 1.53, 95% CI 1.13-2.07). Conclusion: This study identified a number of potentially modifiable risk factors for injuries including: maintenance of healthy weight, improved aerobic endurance, and reduction in smoking. Results also indicate certain Army occupations may be at higher risk of injury. Further investigation into reasons for their higher risk is warranted. (C) 2015 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved. C1 [Anderson, M. K.] USA, Publ Hlth Command, Directorate Epidemiol & Dis Surveillance, Injury Prevent Program, Aberdeen Proving Ground, MD 21010 USA. [Grier, T.; Canham-Chervak, M.; Bushman, T. T.; Jones, B. H.] USA, Publ Hlth Command, Directorate Epidemiol & Dis Surveillance, Aberdeen Proving Ground, MD USA. RP Anderson, MK (reprint author), USA, Publ Hlth Command, Directorate Epidemiol & Dis Surveillance, Injury Prevent Program, Aberdeen Proving Ground, MD 21010 USA. EM morgan.k.anderson.ctr@mail.mil NR 38 TC 2 Z9 2 U1 1 U2 5 PU W B SAUNDERS CO LTD PI LONDON PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND SN 0033-3506 EI 1476-5616 J9 PUBLIC HEALTH JI Public Health PD MAY PY 2015 VL 129 IS 5 BP 531 EP 538 DI 10.1016/j.puhe.2015.02.003 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CJ0EF UT WOS:000355146400016 PM 25770417 ER PT J AU Decker, CL Issa, MA Meyer, KF AF Decker, Curtis L. Issa, Mohsen A. Meyer, Karl F. TI Seismic Investigation of Interior Reinforced Concrete Sand-Lightweight Concrete Beam-Column Joints SO ACI STRUCTURAL JOURNAL LA English DT Article DE beam-column joint; ductility; sand-lightweight concrete; seismic ID SHEAR BEHAVIOR; WIDE COLUMN; CONNECTIONS AB The use of sand-lightweight concrete made with expanded shale aggregate has' become prevalent in recent years. Sand-lightweight concrete is approximately 20% lighter than its normalweight counterpart based on the incorporation of coarse lightweight aggregate. Earthquake forces applied to a building structure are directly proportional to its mass, so the potential for better seismic performance is clear However, concrete made with lightweight aggregate is more brittle in nature than normalweight concrete and, as such, is less ductile. This study focused on determining the behavior of reinforced sand-lightweight concrete beam-column joints of moment frame buildings by subjecting six half-scale test specimens to quasi-static cyclical loading that gave an indication of their ductility in a seismic event. This study found that, if designed and detailed in accordance with current code provisions and if joint shear stress is kept within a reasonable limit, high-strength, sand-lightweight beam-column joints can perform as well as similarly-built normalweight concrete specimens. C1 [Decker, Curtis L.] US Mil Acad, West Point, NY 10996 USA. [Issa, Mohsen A.] Univ Illinois, Civil & Mat Engn, Chicago, IL USA. [Meyer, Karl F.] US Mil Acad, Civil & Mech Engn, West Point, NY 10996 USA. RP Decker, CL (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 25 TC 0 Z9 0 U1 2 U2 8 PU AMER CONCRETE INST PI FARMINGTON HILLS PA 38800 COUNTRY CLUB DR, FARMINGTON HILLS, MI 48331 USA SN 0889-3241 EI 1944-7361 J9 ACI STRUCT J JI ACI Struct. J. PD MAY-JUN PY 2015 VL 112 IS 3 BP 287 EP 297 PG 11 WC Construction & Building Technology; Engineering, Civil; Materials Science, Multidisciplinary SC Construction & Building Technology; Engineering; Materials Science GA CI5VS UT WOS:000354828500003 ER PT J AU Watson, JDB Houston, R Morrison, JJ Gifford, SM Rasmussen, TE AF Watson, J. Devin B. Houston, Robert Morrison, Jonathan J. Gifford, Shaun M. Rasmussen, Todd E. TI A Retrospective Cohort Comparison of Expanded Polytetrafluorethylene to Autologous Vein for Vascular Reconstruction in Modern Combat Casualty Care SO ANNALS OF VASCULAR SURGERY LA English DT Article ID SUBCLAVIAN ARTERY-STENOSIS; PTFE GRAFTS; POLYTETRAFLUOROETHYLENE GRAFTS; LIMB SALVAGE; MICROPOROUS POLYTETRAFLUOROETHYLENE; CONTAMINATED WOUNDS; 20-YEAR EXPERIENCE; PROSTHETIC GRAFTS; AUTOGENOUS VEIN; SAPHENOUS-VEIN AB Background: Reconstruction of vascular injury often requires use of a conduit, either autologous vein (AV) or expanded polytetrafluorethylene (ePTFE). The most common anatomic locations for and durability of ePTFE as an adjunct to vascular repair in the combat setting are unknown. The objectives of this study were to characterize the anatomic locations of use of ePTFE during the wars in Afghanistan and Iraq and to compare its effectiveness to AV. Methods: US service personnel undergoing vascular repair (2002-2012) were identified. Patients in whom ePTFE was used as an interposition conduit (n = 25) were matched with similar patients who received AV (n = 24) reconstruction. Injury and operative factors were assessed, and freedom from graft-related complication was quantified using Kaplan-Meier log-rank test. Results: There was no difference between ePTFE and AV with regard to age, injury severity, or mangled extremity severity score. Follow-up for the ePTFE and AV groups was 71 and 62 months, respectively. In the cohort there was an apparent but not significantly greater freedom from graft-related complication for AV compared with ePTFE (65% vs. 17%; P = 0.13). In the carotid, subclavian, and axillary artery positions, ePTFE performed equal to AV with no apparent difference in freedom from graft-related complications (P = 0.90). However, in the periphery, AV demonstrated greater 8-year freedom from graft-related complication than ePTFE (77% vs. 31%, P = 0.044). Conclusions: AV is a more durable conduit than ePTFE in repair of wartime extremity vascular injury, whereas ePTFE is effective and durable in the carotid, subclavian, and axillary locations. C1 [Watson, J. Devin B.; Houston, Robert; Gifford, Shaun M.] San Antonio Mil Med Ctr, Dept Surg, San Antonio, TX USA. [Watson, J. Devin B.; Houston, Robert; Morrison, Jonathan J.; Rasmussen, Todd E.] US Army Inst Surg Res, San Antonio, TX USA. [Morrison, Jonathan J.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England. [Rasmussen, Todd E.] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, Bethesda, MD 20814 USA. RP Rasmussen, TE (reprint author), US Combat Casualty Care Res Program, 722 Doughten St,Room 3, Ft Detrick, MD 21702 USA. EM todd.e.rasmussen.mil@mail.mil OI Morrison, Jonathan/0000-0001-7462-8456 FU US Army Institute of Surgical Research, Department of Defense Trauma Registry FX The authors would like to acknowledge the hard work of our nurse researchers, Irma McNamee, RN and Thomas Evans, LVN, for their invaluable assistance with data extraction and input into Global War on Terrorism Vascular Injury Initiative database. Additionally, this project would not have been possible without the financial and institutional support of the US Army Institute of Surgical Research to include the Department of Defense Trauma Registry. NR 30 TC 1 Z9 1 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0890-5096 EI 1615-5947 J9 ANN VASC SURG JI Ann. Vasc. Surg. PD MAY PY 2015 VL 29 IS 4 BP 822 EP 829 DI 10.1016/j.avsg.2014.12.026 PG 8 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA CH6DD UT WOS:000354125300027 PM 25736203 ER PT J AU Richards, CR Clark, ME Bowen, DK Uratake, D Ayubi, F Katras, T Kellicut, DC AF Richards, Carly R. Clark, Margaret E. Bowen, Donnell K. Uratake, Denise Ayubi, Farhan Katras, Tony Kellicut, Dwight C. TI Necrotizing Soft Tissue Infection Following a Peripheral Bypass SO ANNALS OF VASCULAR SURGERY LA English DT Article ID LABORATORY RISK INDICATOR; AEROMONAS-HYDROPHILA; FASCIITIS SCORE; EXTREMITY; PROVIDENCIA; PREDICTORS; MORGANELLA; FAILURE; PROTEUS; GRAFT AB Background: Necrotizing soft tissue infection (NSTI), formerly referred to as necrotizing fasciitis, is a rare but serious postoperative complication. NSTI following arterial bypass is seen only once in the literature (for a coronary artery bypass) and is not mentioned following peripheral bypass. Although surgical site infections have been studied extensively, there are limited published data on postoperative NSTI and no data for NSTI following peripheral arterial bypass. Case Presentation: Here we present the first, to our knowledge, reported instance of an NSTI following a lower extremity peripheral bypass. Despite the continued function of the bypass, the patient became rapidly systemically ill with a focus at the surgical site. Because of prompt surgical debridement, the patient survived this severe infection, though did require an above the knee amputation to control the rapid spread of the disease. The patient, a native of American Samoa, was infected with organisms infrequently associated with NSTI, Morganella morganii and Aeromonas hydrophila. This article discusses the diagnosis and treatment of this rare postoperative complication, along with a brief review of the microbiology of the disease. Conclusions: NSTI is a rare but lethal postoperative complication. To our knowledge, this is the first reported case of an NSTI following an arterial peripheral bypass. This patient survived because of prompt and aggressive intervention. C1 [Richards, Carly R.; Clark, Margaret E.; Uratake, Denise; Ayubi, Farhan; Katras, Tony; Kellicut, Dwight C.] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. [Bowen, Donnell K.] Wake Forest Baptist Med Ctr, Dept Surg, Winston Salem, NC USA. RP Richards, CR (reprint author), Tripler Army Med Ctr, Dept Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM Carly.r.richards.mil@mail.mil RI Richards, Carly/I-1783-2016 OI Richards, Carly/0000-0002-3771-220X NR 29 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0890-5096 EI 1615-5947 J9 ANN VASC SURG JI Ann. Vasc. Surg. PD MAY PY 2015 VL 29 IS 4 AR 843.e17 DI 10.1016/j.avsg.2014.12.036 PG 6 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA CH6DD UT WOS:000354125300057 PM 25733218 ER PT J AU Pittari, J Subhash, G Trachet, A Zheng, J Halls, V Karandikar, P AF Pittari, John, III Subhash, Ghatu Trachet, Alison Zheng, James Halls, Virginia Karandikar, Prashant TI The Rate-Dependent Response of Pressureless-Sintered and Reaction-bonded Silicon Carbide-Based Ceramics SO INTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY LA English DT Article ID BORON-CARBIDE; INDENTATION RESPONSE; COMPOSITES; HARDNESS; DAMAGE; SHAPE AB A comparison of the static and dynamic hardness and compressive strengths of seven different commercially available pressureless-sintered (PS) and reaction-bonded (RB) silicon carbide-based ceramics is presented. The intent is to relate these mechanical properties to the microstructure formed during processing. Fine-grained sintered SiC performed better than coarse-grained SiC under indentation and compression loading. The sintered specimens had greater hardness and strength than the RB materials that contained a weaker silicon phase. Composite ceramics containing diamond and boron carbide as secondary phases exhibited greater hardness than the other materials. In addition, the compressive strength and hardness improved with strain rate of deformation for all the materials except for the RB materials and SiC-B4C composite. The weakening effect observed in the SiC-B4C composite during dynamic indentation can be attributed to the B4C phase which exhibits localized amorphization; however, the deleterious effects of B4C amorphization were reduced due to the strain-rate hardening of SiC. C1 [Pittari, John, III; Subhash, Ghatu] Univ Florida, Mech & Aerosp Engn, Gainesville, FL 32611 USA. [Trachet, Alison] Univ Florida, Mat Sci & Engn, Gainesville, FL 32611 USA. [Zheng, James; Halls, Virginia] US Army, Program Execut Off Solider, Ft Belvoir, VA 22060 USA. [Karandikar, Prashant] M Cubed Technol Inc, Newark, DE 19711 USA. RP Pittari, J (reprint author), Univ Florida, Mech & Aerosp Engn, Gainesville, FL 32611 USA. EM subhash@ufl.edu FU Department of the Army FX The authors thank the Department of the Army for funding this research and providing the materials tested. The authors also acknowledge Dr. Brent Gila with the Nanoscale Research Facility at the University of Florida for plasma-etching the RB SiC samples. NR 35 TC 2 Z9 2 U1 3 U2 13 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1546-542X EI 1744-7402 J9 INT J APPL CERAM TEC JI Int. J. Appl. Ceram. Technol. PD MAY-JUN PY 2015 VL 12 SU 2 SI SI BP E207 EP E216 DI 10.1111/ijac.12332 PG 10 WC Materials Science, Ceramics SC Materials Science GA CI2BU UT WOS:000354550500029 ER PT J AU Jang, C Sirk, TW Andzelm, JW Abrams, CF AF Jang, Changwoon Sirk, Timothy W. Andzelm, Jan W. Abrams, Cameron F. TI Comparison of Crosslinking Algorithms in Molecular Dynamics Simulation of Thermosetting Polymers SO MACROMOLECULAR THEORY AND SIMULATIONS LA English DT Article ID LINKED EPOXY; EFFICIENT GENERATION; AM1-BCC MODEL; FORCE-FIELD; COMPOSITES; RESIN AB The generation of fully cross-linked structure is a central task in molecular dynamics simulations of thermosetting polymers. Several algorithms for generating such structures exist, but it is so far not clear what impact the choice of algorithm has on thermal and material properties one typically wants to use simulations to predict. We generated cross-linked systems comprised of stoichiometric amounts of diglycidyl ether of bisphenol A and poly(oxyproplylene) diamine using two methods: (1) a single-step approach, in which cross-link bonds are assigned based on a Monte-Carlo algorithm that minimizes aggregate bond lengths, and (2) a multi-step approach, which uses an incrementally increasing capture radius to identify bonding partners. The choice of cross-linking method has only a minimal impact on thermal and mechanical properties. The minimum nitrogen-to-nitrogen contour-length distributions are also insensitive to the method. However, significant differences were found in the molecular weight distribution of fragments formed by cutting each POP cross-linker between the amines: the single-step method results in fewer, larger fragments compared to the multi-step method. This indicates that the networks formed by the two methods are qualitatively different, and underscores the need for further studies to characterize the influence of polymer network connectivity both in simulations and experiments. C1 [Jang, Changwoon; Abrams, Cameron F.] Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA. [Sirk, Timothy W.; Andzelm, Jan W.] US Army, Macromol Sci & Technol Branch, Res Lab, Aberdeen, MD 21005 USA. RP Abrams, CF (reprint author), Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA. EM cfa22@drexel.edu FU Materials in Extreme Dynamic Environments (MEDE) Consortium; US Army Research Lab; Army Research Lab [W911NF-12-2-0022]; National Science Foundation [OCI-105375, TG-MCB070073N, TG-CHE130061]; US Air Force Research Laboratory-DOD Supercomputing Resource Center Environment (AFRL DSRC) [ARLAP35100034] FX This work has been supported by the Cooperative Agreement between the Materials in Extreme Dynamic Environments (MEDE) Consortium and US Army Research Lab. Army Research Lab under Contract No. W911NF-12-2-0022. This work used the Extreme Science and Engineering Discovery Environment (XSEDE), which is supported by National Science Foundation grant number OCI-105375 (allocation TG-MCB070073N and TG-CHE130061) and US Air Force Research Laboratory-DOD Supercomputing Resource Center Environment (AFRL DSRC) (allocation ARLAP35100034). NR 20 TC 10 Z9 10 U1 3 U2 25 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY SN 1022-1344 EI 1521-3919 J9 MACROMOL THEOR SIMUL JI Macromol. Theory Simul. PD MAY PY 2015 VL 24 IS 3 BP 260 EP 270 DI 10.1002/mats.201400094 PG 11 WC Polymer Science SC Polymer Science GA CI6RV UT WOS:000354889600007 ER PT J AU Hoffmann, MP Kirste, R Mita, S Guo, W Tweedie, J Bobea, M Bryan, I Bryan, Z Gerhold, M Collazo, R Sitar, Z AF Hoffmann, Marc Patrick Kirste, Ronny Mita, Seiji Guo, Wei Tweedie, James Bobea, Milena Bryan, Isaac Bryan, Zachary Gerhold, Michael Collazo, Ramon Sitar, Zlatko TI Growth and characterization of AlxGa1-xN lateral polarity structures SO PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE LA English DT Article; Proceedings Paper CT 8th International Workshop on Nitride Semiconductors(IWN 2014) CY AUG 24-29, 2015 CL Wroclaw, POLAND DE AlGaN; growth; lateral polarity structures; optical phase matching ID OPTICAL 2ND-HARMONIC GENERATION; WAVE-GUIDES; GAN AB AlGaN lateral polarity structures (LPS) with varying Al composition, have been fabricated by metalorganic chemical vapour deposition on LPS templates containing mu m size domains. III-metal and N-polar AlGaN domains have been grown on LT-AlN and c-sapphire domains, respectively. LPS characterization by SEM and AFM reveals two major effects when the Al composition has been varied: (a) A high Al content leads to columnar growth within N-polar domains and (b) a height difference between the polar domains can be observed for low Al compositions towards III-polarity. The surface quality of the III-polar domains is not effected by the Al composition. The surface roughness of N-polar domains decreases for lower Al compositions. The high periodicity of the polar domains and the high quality of the boundary between domains suggest a high potential of AlGaN LPS to be used as lateral wave guides for quasi phase matching. C1 [Hoffmann, Marc Patrick; Kirste, Ronny; Guo, Wei; Tweedie, James; Bobea, Milena; Bryan, Isaac; Bryan, Zachary; Collazo, Ramon; Sitar, Zlatko] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27606 USA. [Mita, Seiji] HexaTech Inc, Morrisville, NY 27560 USA. [Gerhold, Michael] Army Res Off, Engn Sci Directorate, Res Triangle Pk, NC 27703 USA. RP Hoffmann, MP (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, 1001 Capabil Dr, Raleigh, NC 27606 USA. EM marc_hoffmann@ncsu.edu FU Army Research Office [W911NF-04-D003]; William Clark program monitor; NSF [DMR-1108071, DMR-1312582]; NDSEG Fellowship; DoD, Air Force Office of Scientific Research [32 CFR 168a]; National Research Council Research Associateship Award FX This work was supported in part by the Army Research Office, contract#: W911NF-04-D003, William Clark program monitor, NSF under contract DMR-1108071 and DMR-1312582 and NDSEG Fellowship under and awarded by DoD, Air Force Office of Scientific Research, 32 CFR 168a. Part of this research was performed while the first author held a National Research Council Research Associateship Award. NR 16 TC 3 Z9 3 U1 8 U2 29 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 1862-6300 EI 1862-6319 J9 PHYS STATUS SOLIDI A JI Phys. Status Solidi A-Appl. Mat. PD MAY PY 2015 VL 212 IS 5 SI SI BP 1039 EP 1042 DI 10.1002/pssa.201431740 PG 4 WC Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Materials Science; Physics GA CI0DB UT WOS:000354405000024 ER PT J AU Scott, VD Schobitz, RP Grace, G Patterson, TJ AF Scott, Valerie D. Schobitz, Richard P. Grace, Gerard Patterson, Thomas J. TI Addressing Deficits in the Utilization of Empirically Supported Treatments for Posttraumatic Stress Disorder: Training the Future of Army Psychology SO TRAINING AND EDUCATION IN PROFESSIONAL PSYCHOLOGY LA English DT Article DE posttraumatic stress disorder (PTSD); prolonged exposure; cognitive processing therapy; empirically supported treatments; evidence-based practice ID COGNITIVE-PROCESSING THERAPY; PROLONGED EXPOSURE; ATTITUDES; PTSD; DISSEMINATION; AFGHANISTAN; VETERANS; TRIAL; IRAQ AB The estimated incidence of posttraumatic stress disorder (PTSD) among individuals who have fought in the wars in Iraq and Afghanistan is between 13% and 17% (Joint Mental Health Advisory Team [J-MHAT 7], 2011). Fortunately, several empirically supported treatments (ESTs) exist that are quick and effective, including prolonged exposure (PE) and cognitive processing therapy (CPT; Foa et al., 2005; Monson et al., 2012; Resick, Nishith, Weaver, Astin, & Feuer, 2002). However, many clinicians do not implement these modalities for multiple reasons, the most prevailing barrier being a lack of training (Becker, Zayfert, & Anderson, 2004; Grace, 2013). The psychology training program in the Department of Behavioral Medicine at Brooke Army Medical Center has sought to address this issue by implementing a 2-year EST training program for psychology predoctoral interns and postdoctoral residents. The first step in the process is to train interns on EST protocols through workshops that include didactic training, review of video of treatment, and role-play. The next step is to provide the trainees with supervised experiences utilizing EST protocols. From 2011-2013, our trainees began treatment with an EST for PTSD with 153 individuals, and 65 individuals completed an EST treatment protocol. These clinicians graduate from the training program after receiving extensive didactic training, clinical experience, and ongoing supervision and consultation aimed at increasing familiarity in the utilization of PE and CPT. C1 [Scott, Valerie D.; Grace, Gerard] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Schobitz, Richard P.] Brooke Army Med Ctr, Training & Res Div, Dept Behav Med, Ft Sam Houston, TX 78234 USA. [Patterson, Thomas J.] Brooke Army Med Ctr, APA Accredited Clin Psychol Internship Program, Ft Sam Houston, TX 78234 USA. RP Schobitz, RP (reprint author), Dept Behav Med, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Richard.PSchobitz.mil@mail.mil NR 25 TC 1 Z9 1 U1 0 U2 3 PU EDUCATIONAL PUBLISHING FOUNDATION-AMERICAN PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST, NE, WASHINGTON, DC 20002-4242 USA SN 1931-3918 EI 1931-3926 J9 TRAIN EDUC PROF PSYC JI Train. Educ. Prof. Psychol. PD MAY PY 2015 VL 9 IS 2 BP 85 EP 91 DI 10.1037/tep0000044 PG 7 WC Psychology, Educational SC Psychology GA CI2VZ UT WOS:000354607000002 ER PT J AU Seehusen, DA Ledford, CJW AF Seehusen, Dean A. Ledford, Christy J. W. TI Program Directors' Use and Perceptions of the Online STFM Resource Library: A CERA Report SO FAMILY MEDICINE LA English DT Article AB BACKGROUND AND OBJECTIVES: The online STFM Resource Library (RL) was launched in 2005 by STFM with a grant from the National Library of Medicine. This study was conducted to assess the RL usage patterns and RL-related perceptions of family medicine program directors (PDs) to guide potential process improvement. METHODS: Questions about the RL were included in a larger omnibus survey conducted by the CAFM Educational Research Alliance (CERA). The sampling frame for the survey was all US family medicine PDs as identified by the Association of Family Medicine Residency Directors. RESULTS: The overall response rate was 50.9% (224/440). A total of 170 (75.9%) had previously used the RL. PDs from university-affiliated programs were more likely to have used the RL (92.7% versus 73.7%). Forty percent of respondents reported the RL was easy to use, and 25.3% agreed that the RL is more valuable than other medical education web sites. Respondents who had been PD for less than 5 years reported a greater relative advantage of the RL (31.9% versus 17.9%). Women reported higher relative advantage for the RI than men (34.5% versus 20.5%). CONCLUSIONS: PDs who have used the site report relatively low satisfaction with its ease of use and relative value. Most do not consider it to be more useful than other medical education web sites. Women PDs rate the resource higher than men. The RL is a widely used resource that could be updated to make it easier to use and more valuable to family medicine educators. C1 [Seehusen, Dean A.] Dept Family & Community Med, Ft Gordon, GA USA. [Ledford, Christy J. W.] Uniformed Serv Univ Hlth Sci, Dept Family Med, Bethesda, MD 20814 USA. RP Seehusen, DA (reprint author), Eisenhower Army Med Ctr, Dept Family & Community Med, 214 Bainbridge Dr, Evans, GA 30809 USA. EM dseehusen@msn.com NR 4 TC 0 Z9 0 U1 0 U2 2 PU SOC TEACHERS FAMILY MEDICINE PI LEAWOOD PA 11400 TOMAHAWK CREEK PARKWAY, STE 540, LEAWOOD, KS 66207 USA SN 0742-3225 EI 1938-3800 J9 FAM MED JI Fam. Med. PD MAY PY 2015 VL 47 IS 5 BP 393 EP 396 PG 4 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA CI2OE UT WOS:000354586100011 PM 25905884 ER PT J AU Tzeng, JT Hsieh, KT AF Tzeng, Jerome T. Hsieh, Kuo-Ta TI Electromagnetic Field Effect and Analysis of Composite Structure SO IEEE TRANSACTIONS ON PLASMA SCIENCE LA English DT Article DE Anisotropy; composites; electromagnetic; induction; railgun AB The electromagnetic and thermal response of composites subjected to magnetic fields is simulated by solving Maxwell and heat transfer equations simultaneously. The developed analysis accounts for the anisotropic nature of the electrical and thermal properties in three dimensions. A finite-element code is developed to predict the response of composite structures subjected to transient magnetic fields. The analysis has been validated against a closed-form solution and applied to simulate the induction heating process of composite cylinders. The developed analysis can be applied to the design of modern electrical weapons and used to simulate composite manufacturing processes such as induction cure. C1 [Tzeng, Jerome T.] US Army Res Lab, Aberdeen, MD 21911 USA. [Hsieh, Kuo-Ta] Univ Texas Austin, Austin, TX 78759 USA. RP Tzeng, JT (reprint author), US Army Res Lab, Aberdeen, MD 21911 USA. EM jerome.t.tzeng.civ@mail.mil; k.hsieh@cem.utexas.edu NR 5 TC 0 Z9 0 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0093-3813 EI 1939-9375 J9 IEEE T PLASMA SCI JI IEEE Trans. Plasma Sci. PD MAY PY 2015 VL 43 IS 5 SI SI BP 1536 EP 1540 DI 10.1109/TPS.2015.2404136 PN 1 PG 5 WC Physics, Fluids & Plasmas SC Physics GA CH9PT UT WOS:000354368900073 ER PT J AU Janak, J Cooper, D Bowles, A Orman, J AF Janak, Jud Cooper, Douglas Bowles, Amy Orman, Jeana TI Multidisciplinary Treatment of Patients With Persistent Post Concussive Complaints Significantly Reduces Symptom Burden SO JOURNAL OF HEAD TRAUMA REHABILITATION LA English DT Meeting Abstract C1 [Janak, Jud; Orman, Jeana] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX USA. [Bowles, Amy] Brooke Army Med Ctr, Jbsa Ft Sam Houston, TX USA. [Cooper, Douglas] Def & Vet Brain Injury Ctr, Jbsa Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0885-9701 EI 1550-509X J9 J HEAD TRAUMA REHAB JI J. Head Trauma Rehabil. PD MAY-JUN PY 2015 VL 30 IS 3 MA 0039 BP E76 EP E76 PG 1 WC Clinical Neurology; Rehabilitation SC Neurosciences & Neurology; Rehabilitation GA CH8PJ UT WOS:000354298100041 ER PT J AU Tarney, C Berry-Caban, C Jain, R Kelly, M Sewell, M Wilson, K AF Tarney, Christopher Berry-Caban, Cristobal Jain, Ram Kelly, Molly Sewell, Mark Wilson, Karen TI Effects of Spouse Deployment on Pregnancy Outcomes A Prospective Cohort of a Military Population SO OBSTETRICS AND GYNECOLOGY LA English DT Meeting Abstract CT 61st Annual Clinical Meeting of the American-College-of-Obstetricians-and-Gynecologists - Women's Health Care Physicians CY MAY 07, 2013 CL New Orleans, LA SP Amer Coll Obstetricians & Gynecologists C1 [Tarney, Christopher] Womack Army Med Ctr, Ft Bragg, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD MAY PY 2015 VL 125 SU 1 MA 20 BP 16S EP 17S PG 2 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA CH6EI UT WOS:000354128700049 ER PT J AU Fulgoni, VL Keast, DR Lieberman, HR AF Fulgoni, Victor L., III Keast, Debra R. Lieberman, Harris R. TI Trends in intake and sources of caffeine in the diets of US adults: 2001-2010 SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Article DE NHANES; coffee; tea; energy drinks; usual intake; beverages ID COFFEE CONSUMPTION; BLOOD-PRESSURE; UNITED-STATES; METAANALYSIS; MORTALITY; CHILDREN; STRESS; ENERGY; COHORT AB Background: Coffee and tea are traditional sources of caffeine in the diet, but other sources, such as energy drinks, are now available. Because risks and benefits of caffeine use are dose dependent, the public health consequences of caffeine consumption cannot be determined without data on amounts currently consumed by the US population. Objective: The objective was to obtain an up-to-date, nationally representative estimate of caffeine consumption in adults. Design: Dietary intake data from NHANES from 2001 to 2010 for adults >= 19 y of age were used (n = 24,808). Acute and usual intake of caffeine was estimated from all caffeine-containing foods and beverages. Trends in consumption and changes in sources of caffeine were also examined. Results: Eighty-nine percent of the adult US population consumed caffeine, with equal prevalence in men and women. Usual mean +/- SE per capita caffeine consumption when nonusers were included was 186 +/- 4 mg/d, with men consuming more than women (211 +/- 5 vs. 161 +/- 3 mg/d, P < 0.05). Usual intake in consumers was 211 +/- 3 mg/d, with 240 +/- 4 mg/d in men and 183 +/- 3 mg/d in women (P < 0.05); 46% was consumed in a single consumption event. In consumers, acute 90th and 99th percentiles of intake were 436 and 1066 mg/d, respectively. Consumption was highest in men aged 31-50 y and lowest in women aged 19-30 y. Beverages provided 98% of caffeine consumed, with coffee (similar to 64%), tea (similar to 16%), and soft drinks (similar to 18%) predominant sources; energy drinks provided <1%, but their consumption increased substantially from 2001 to 2010. Conclusions: Although new caffeine-containing products were introduced into the US food supply, total per capita intake was stable over the period examined. C1 [Fulgoni, Victor L., III] Nutr Impact LLC, Battle Creek, MI 49014 USA. [Fulgoni, Victor L., III; Keast, Debra R.] Oak Ridge Inst Sci & Educ, Belcamp, MD USA. [Keast, Debra R.] Food & Nutr Database Res Inc, Okemos, MI USA. [Lieberman, Harris R.] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA USA. RP Fulgoni, VL (reprint author), Nutr Impact LLC, 9725 D Dr North, Battle Creek, MI 49014 USA. EM vic3rd@aol.com FU US Army Medical Research and Materiel Command; Department of Defense Center Alliance for Dietary Supplement Research FX Supported by the US Army Medical Research and Materiel Command and the Department of Defense Center Alliance for Dietary Supplement Research. NR 32 TC 19 Z9 19 U1 5 U2 31 PU AMER SOC NUTRITION-ASN PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0002-9165 EI 1938-3207 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD MAY PY 2015 VL 101 IS 5 BP 1081 EP 1087 DI 10.3945/ajcn.113.080077 PG 7 WC Nutrition & Dietetics SC Nutrition & Dietetics GA CH5KS UT WOS:000354075100023 PM 25832334 ER PT J AU Schlussel, AT Lustik, MB Johnson, EK Maykel, JA Champagne, BJ Goldberg, JE Steele, SR AF Schlussel, Andrew T. Lustik, Michael B. Johnson, Eric K. Maykel, Justin A. Champagne, Brad J. Goldberg, Joel E. Steele, Scott R. TI A population-based comparison of open versus minimally invasive abdominoperineal resection SO AMERICAN JOURNAL OF SURGERY LA English DT Article; Proceedings Paper CT Annual Meeting of the North-Pacific-Surgical-Association CY NOV 14-15, 2014 CL Seattle, WA SP N Pacific Surg Assoc DE Abdominoperineal resection; Laparoscopy; Proctectomy; Postoperative complications; Population database ID SHORT-TERM OUTCOMES; COLORECTAL-CANCER CARE; LOW RECTAL-CANCER; RANDOMIZED-TRIAL; OPEN COLECTOMY; COLON-CANCER; LAPAROSCOPY; DISPARITIES; SURGERY AB BACKGROUND: Although minimally invasive colorectal surgery increases widely, outcomes following its use in complex operations such as the abdominoperineal resection (APR) remain indeterminate. METHODS: A review of the Nationwide Inpatient Sample (2008 to 2011) of all patients undergoing elective laparoscopic or open APR was conducted. Risk-adjusted 30-day outcomes were assessed using regression modeling accounting for patient characteristics, comorbidities, and surgical procedure. RESULTS: We identified 3,191 admissions meeting inclusion criteria (1,019 laparoscopic; 2,172 open). The conversion rate was 5%. Mortality was low and similar between groups (.88% vs .83%, P = .91). In-hospital complication rates were lower in the laparoscopic group (19% vs 29%, odds ratio .59, 95% confidence interval .49 to .71, P < .01), but conversion was associated with a higher rate (29% vs 18%, P < .01). Finally, a laparoscopic APR was associated with a shorter length of stay (5.3 vs 7.0 days, P < .01). CONCLUSION: Laparoscopic APR is associated with improved outcomes and may be the preferred approach by surgeons with appropriate skills and experience. Published by Elsevier Inc. C1 [Schlussel, Andrew T.] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. [Lustik, Michael B.] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. [Johnson, Eric K.; Steele, Scott R.] Madigan Army Med Ctr, Dept Surg, Ft Lewis, WA 98431 USA. [Maykel, Justin A.] Univ Massachusetts, Div Colorectal Surg, Mem Med Ctr, Worcester, MA 01605 USA. [Champagne, Brad J.] Univ Hosp Case Med Ctr, Div Colorectal Surg, Dept Surg, Cleveland, OH USA. [Goldberg, Joel E.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Sect Colorectal Surg, Boston, MA 02115 USA. RP Steele, SR (reprint author), Madigan Army Med Ctr, Dept Surg, Ft Lewis, WA 98431 USA. EM harkersteele@mac.com OI Schlussel, Andrew /0000-0001-9933-6513 NR 26 TC 3 Z9 3 U1 0 U2 2 PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC PI BRIDGEWATER PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA SN 0002-9610 EI 1879-1883 J9 AM J SURG JI Am. J. Surg. PD MAY PY 2015 VL 209 IS 5 BP 815 EP 823 DI 10.1016/j.amjsurg.2014.12.021 PG 9 WC Surgery SC Surgery GA CH4XB UT WOS:000354035500015 PM 25766119 ER PT J AU Rodkvamtook, W Zhang, ZW Chao, CC Huber, E Bodhidatta, D Gaywee, J Grieco, J Sirisopana, N Kityapan, M Lewis, M Ching, WM AF Rodkvamtook, Wuttikon Zhang, Zhiwen Chao, Chien-Chung Huber, Erin Bodhidatta, Dharadhida Gaywee, Jariyanart Grieco, John Sirisopana, Narongrid Kityapan, Manerat Lewis, Michael Ching, Wei-Mei TI Dot-ELISA Rapid Test Using Recombinant 56-kDa Protein Antigens for Serodiagnosis of Scrub Typhus SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID RICKETTSIA-TSUTSUGAMUSHI; ORIENTIA-TSUTSUGAMUSHI; DIAGNOSIS; ANTIBODY; INFECTION; ASSAYS; REACTIVITY; THAILAND; DISEASES AB We developed a rapid dot enzyme-linked immunosorbent assay (dot-ELISA) using the combination of recombinant 56-kDa protein antigens that exhibited broad reactivity with serum antibodies against the four most prevalent strains (Karp, Kato, Gilliam, and TA763) of Orientia tsutsugamushi. The assay is rapid (30 minutes), and can be done at room temperature, and results can be read by the naked eye. Only a simple shaker is required to wash the membrane. Sera from 338 patients suspected of being ill with scrub typhus from rural hospitals around Thailand were tested using this dot-ELISA. Seventy-five (22.2%) patients were found to be positive. The sensitivity and specificity of dot-ELISA were determined using the indirect immunofluorescent assay (IFA) test as the gold standard, with the cutoff titer of immunoglobulin peroxidase conjugate M (IgM)/G (IgG) greater than 1:400/1:400. The dot-ELISA had a sensitivity of 98.5%, a specificity of 96.3%, a positive predictive value of 86.7%, and a negative predictive value of 99.6% for the acute-phase specimens. The results indicate that dot-ELISA rapid test using recombinant 56-k Da protein antigen was comparable with the IFA test and may be very useful for the diagnosis of scrub typhus in rural hospitals, where IFA is not available. C1 Royal Thai Army, AFRIMS, Bangkok, Thailand. Naval Med Res Ctr, Silver Spring, MD 20910 USA. [Zhang, Zhiwen; Chao, Chien-Chung; Huber, Erin; Grieco, John; Lewis, Michael; Ching, Wei-Mei] Uniformed Serv Univ Hlth Sci, Prevent Med & Biometr Dept, Bethesda, MD 20814 USA. [Rodkvamtook, Wuttikon; Bodhidatta, Dharadhida; Gaywee, Jariyanart; Sirisopana, Narongrid; Kityapan, Manerat] Armed Forces Res Inst Med Sci, Microbiol, Bangkok, Thailand. [Zhang, Zhiwen; Chao, Chien-Chung; Huber, Erin; Ching, Wei-Mei] Naval Med Res Ctr, Viral & Rickettsial Dis Dept, Silver Spring, MD 20910 USA. RP Ching, WM (reprint author), Naval Med Res Ctr, Viral & Rickettsial Dis Program, Dept Infect Dis, Code 41, Silver Spring, MD 20910 USA. EM ltwutti@hotmail.com; Zhiwen.zhang@med.navy.mil; chien-chung.chao@med.navy.mil; erin.huber@med.navy.mil; dbodhi@hotmail.com; jariyanart@yahoo.com; johngrieco88@gmail.com; Narongrid1956@yahoo.com; krataii_usagi@hotmail.com; dr.michael.lewis@gmail.com; wei.ching@med.navy.mil FU Royal Thai Army; [6000 (RAD1.J.A0310)] FX Support for this study was provided by the Royal Thai Army (to W.R.). Part of the work collaborating with the Naval Medical Research Center (NMRC) was supported by Work Unit Number 6000 (RAD1.J.A0310). NR 31 TC 3 Z9 4 U1 1 U2 9 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD MAY PY 2015 VL 92 IS 5 BP 967 EP 971 DI 10.4269/ajtmh.14-0627 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA CH5KQ UT WOS:000354074900017 PM 25802430 ER PT J AU Caraballo, H De Lorenzo, RA AF Caraballo, Hector De Lorenzo, Robert A. TI Overcoming the 911 Fear Factor SO ANNALS OF EMERGENCY MEDICINE LA English DT Editorial Material ID UNITED-STATES; AMERICA; CARE C1 [Caraballo, Hector; De Lorenzo, Robert A.] Univ Texas Hlth Sci Ctr San Antonio, Dept Emergency Med, San Antonio, TX 78229 USA. [De Lorenzo, Robert A.] US Army Inst Surg Res, Tact Combat Casualty Care Res Program, Jbsa Ft Sam Houston, TX USA. RP De Lorenzo, RA (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Emergency Med, San Antonio, TX 78229 USA. EM robert.a.delorenzo.mil@mail.mil NR 13 TC 0 Z9 0 U1 1 U2 3 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD MAY PY 2015 VL 65 IS 5 BP 553 EP 555 DI 10.1016/j.annemergmed.2014.12.006 PG 3 WC Emergency Medicine SC Emergency Medicine GA CH3JM UT WOS:000353927000014 PM 25544736 ER PT J AU Mhin, S Nittala, K Cozzan, C Kim, K Robinson, DS Sanchez, LM Polcawich, RG Jones, JL AF Mhin, Sungwook Nittala, Krishna Cozzan, Clayton Kim, Kyeongwon Robinson, Douglas S. Sanchez, Luz M. Polcawich, Ronald G. Jones, Jacob L. TI Role of the PbTiO3 Seed Layer on the Crystallization Behavior of PZT Thin Films SO JOURNAL OF THE AMERICAN CERAMIC SOCIETY LA English DT Article ID LEAD-ZIRCONATE-TITANATE; MICROSTRUCTURE EVOLUTION; PIEZOELECTRIC PROPERTIES; TEXTURE DEVELOPMENT; PHASE; MEMS; DIFFRACTION; DEPOSITION; KINETICS AB The role of a highly crystalline and oriented lead titanate (PTO) seed layer on the subsequent phase and texture evolution of lead zirconate titanate (PZT) thin films is investigated in situ using X-ray diffraction (XRD) during crystallization. Crystalline PTO seed layers were first prepared via a 2-methoxyethanol route. Amorphous PZT with a Zr/Ti ratio of 52/48 was then deposited on the seed layer using the same synthesis route and subsequently crystallized in situ during XRD. During heating, a tetragonal-to-cubic transformation of the seed layer occurs prior to the formation of perovskite PZT. Subsequent nucleation of the crystalline PZT occurs in the cubic phase. Simultaneous to nucleation of PZT, development of a dominant 100 texture component was observed in the PZT phase of the thin films. The results indicate that 100 textured PTO nucleates 100 texture of PZT thin films during crystallization. C1 [Mhin, Sungwook; Nittala, Krishna; Cozzan, Clayton; Kim, Kyeongwon] Korea Inst Ind Technol, Inchon 406840, South Korea. [Robinson, Douglas S.] Argonne Natl Lab, Adv Photon Source, Argonne, IL 60439 USA. [Sanchez, Luz M.; Polcawich, Ronald G.] US Army Res Lab, PiezoMEMS, Adelphi, MD 20783 USA. [Jones, Jacob L.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. RP Jones, JL (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Box 7907, Raleigh, NC 27695 USA. EM jacobjones@ncsu.edu OI Cozzan, Clayton/0000-0003-3409-0377 FU NSF [DMR-1207293]; U.S. Department of the Army [W911NF-09-1-0435]; U.S. DOE [DE-AC02-06CH11357]; Korea Institute of Industrial Technology (KITECH) FX This work was supported by NSF under DMR-1207293, and partially by the U.S. Department of the Army under W911NF-09-1-0435. Use of the Advanced Photon Source, an Office of Science User Facility operated for the U.S. Department of Energy (DOE) Office of Science by Argonne National Laboratory, was supported by the U.S. DOE under contract no. DE-AC02-06CH11357. This work was supported by a grant from Korea Institute of Industrial Technology (KITECH). We thank Jason Nikkel and Jennifer Forrester for help with figure development and constructive feedback on the manuscript text. The authors thank Dr. Daniel Potrepka and Joel Martin of the US Army Research Laboratory for their contributions in preparing the Pt coated substrates. NR 29 TC 5 Z9 5 U1 0 U2 25 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-7820 EI 1551-2916 J9 J AM CERAM SOC JI J. Am. Ceram. Soc. PD MAY PY 2015 VL 98 IS 5 BP 1407 EP 1412 DI 10.1111/jace.13468 PG 6 WC Materials Science, Ceramics SC Materials Science GA CH2TK UT WOS:000353877300005 ER PT J AU Mikijelj, B Nawaz, Z Kruzic, JJ Idrobo, J Swab, JJ Ozcoban, H Jelitto, H Schneider, GA Fett, T Liu, Y AF Mikijelj, Biljana Nawaz, Zubair Kruzic, Jamie J. Idrobo, Juan Swab, Jeffrey J. Oezcoban, Husseyin Jelitto, Hans Schneider, Gerold A. Fett, Theo Liu, Yi TI Intergranular Nanostructure Effects on Strength and Toughness of Si3N4 SO JOURNAL OF THE AMERICAN CERAMIC SOCIETY LA English DT Article ID IMPROVED FRACTURE-TOUGHNESS; SILICON-NITRIDE CERAMICS; MICROSTRUCTURAL DESIGN; MECHANICAL-PROPERTIES; BRIDGING CERAMICS; CRACK-GROWTH; R-CURVES; BEHAVIOR; MG; ADDITIVES AB Strength, toughness, microstructure, and atomic adsorption arrangement in silicon nitrides with MgO and RE2O3 additions (RE = La, Gd, Y, Lu) were examined. Mechanical properties were high for La, Gd, and equal La-Lu additions, but surprisingly were progressively lower for Y-and Lu-doped samples. The lower strength and toughness were associated with fewer visible crack deflections and grain bridges. Detailed microstructural analysis of the Lu-doped material revealed a complex intergranular nanostructure with variable Lu content and Si3N4 nanocrystals. Furthermore, the Lu-rich areas showed an extra Lu-adsorption site on the Si3N4 prismatic planes not previously observed in other studies. This inhomogeneous structure was attributed to grain growth impingement and higher viscosity of the Lu-doped oxynitride glass that slows homogenization. The Y-doped material with nearly identical glass viscosity demonstrates intermediate behavior. Finally, substituting half of the Lu2O3 with La2O3 resulted in a homogenous intergranular structure, attributed to a lower viscosity of the oxynitride glass phase, and high mechanical properties. Overall, care must be taken when adapting Si3N4 processing parameters for the smaller ionic radius rare earth dopants such as Lu and Y. C1 [Mikijelj, Biljana; Nawaz, Zubair] Ceradyne Inc, Costa Mesa, CA 92626 USA. [Kruzic, Jamie J.] Oregon State Univ, Mat Sci, Sch Mech Ind & Mfg Engn, Corvallis, OR 97331 USA. [Idrobo, Juan] Oak Ridge Natl Lab, Ctr Nanophase Mat Sci, Oak Ridge, TN 37831 USA. [Swab, Jeffrey J.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Oezcoban, Husseyin; Jelitto, Hans; Schneider, Gerold A.] Hamburg Univ Technol, Inst Adv Ceram, D-21073 Hamburg, Germany. [Fett, Theo] Karlsruhe Inst Technol, Inst Appl Mat, D-76131 Karlsruhe, Germany. [Liu, Yi] N Carolina State Univ, Analyt Instrumentat Facil, Raleigh, NC 27659 USA. RP Mikijelj, B (reprint author), Ceradyne Inc, 3169 Redhill Ave, Costa Mesa, CA 92626 USA. EM bmikijelj@mmm.com RI Kruzic, Jamie/M-3558-2014; OI Kruzic, Jamie/0000-0002-9695-1921; Idrobo, Juan Carlos/0000-0001-7483-9034; Liu, Yi/0000-0001-6996-8843 FU ARL [W911Qx-09-0069]; Alexander von Humboldt Foundation Friedrich Wilhelm Bessel Award FX Work reported was partially funded by ARL contract #W911Qx-09-0069. We are grateful to Dr. Paul Becher for discussions during the program and for providing a sample from his work for comparison to ours. JJK gratefully acknowledges funding from the Alexander von Humboldt Foundation Friedrich Wilhelm Bessel Award. The authors acknowledge the use of the Analytical Instrumentation Facility (AIF) at North Carolina State University, which is supported by the State of North Carolina and the National Science Foundation. NR 28 TC 1 Z9 1 U1 6 U2 36 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-7820 EI 1551-2916 J9 J AM CERAM SOC JI J. Am. Ceram. Soc. PD MAY PY 2015 VL 98 IS 5 BP 1650 EP 1657 DI 10.1111/jace.13484 PG 8 WC Materials Science, Ceramics SC Materials Science GA CH2TK UT WOS:000353877300039 ER PT J AU Campbell, JE Aden, JK Cap, AP AF Campbell, James Eric Aden, James Keith Cap, Andrew Peter TI Acute traumatic coagulopathy: Whole blood thrombelastography measures the tip of the iceberg SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Erythrocyte; red blood cells; acidemia; thrombelastography; tissue factor ID ROTATION THROMBELASTOGRAPHY; TRANSFUSION REQUIREMENTS; THROMBIN GENERATION; HEMORRHAGIC-SHOCK; CLOT FORMATION; COAGULATION; ACIDOSIS; CARE; HEMOSTASIS; HEMATOCRIT AB BACKGROUND: Thrombelastography (TEG) is suggested as an optimal instrument for the identification of acute traumatic coagulopathy-induced alterations in coagulation status. Patient whole blood (WB) used in TEG analysis is generally collected from a large blood vessel containing representative systemic blood, often close to 40% hematocrit (Hct). Trauma patients often exhibit bleeding from the microvasculature. This study examines early coagulation function changes at the simulated microvascular level based on altered Hct and pH in vitro through TEG analyses of normal donor blood. METHODS: Anticoagulated normophysiologic fresh human blood was centrifuged. Individual component effects on coagulation were investigated through variable recombination groups: platelet-rich plasma (PRP), platelet-poor plasma (PPP), and red blood cells (RBCs), which were compared with WB. Acute traumatic coagulopathy-induced acidic microvascular environment was simulated and investigated using tissue factor-activated TEG analysis of variable Hct (40%, 30%, 20%, and 0%) samples and variable [H+]. Incremental replacement of RBC with either PPP or normal saline (NS) simulated resuscitation in vitro was also conducted under similar conditions. RESULTS: Only acidified PRP reflected loss of clot strength. Acidified PRP and PPP were delayed equally in clot time. In all groups, inclusion of RBCs normalized clot time. RBC replacement with PPP significantly delayed clot time when samples were acid-challenged, signifying greater acid effect in low Hct microvascular beds. NS simulated resuscitation incurred even greater clotting delays. CONCLUSION: Acidemia-induced coagulopathy at the level of the capillary Hct (1) is more severe than at higher Hct levels (larger blood vessels), (2) shows that simulated resuscitation with NS causes greater increases in clot time and decreases in clot strength beyond that which occurs with plasma replacement, and (3) may not accurately be portrayed through common TEG practice of testing systemic WB of greater than 30% Hct. (J Trauma Acute Care Surg. 2015; 78: 955-961. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved.) C1 [Campbell, James Eric] US Army Inst Surg Res, Joint Inflammat Modulat Trauma Program, Triserv Res Labs, San Antonio, TX USA. [Campbell, James Eric] US Army Inst Surg Res, Joint Inflammat Modulat Trauma Program, Triserv Res Labs, San Antonio, TX USA. [Aden, James Keith; Cap, Andrew Peter] US Army Inst Surg Res, Coagulat & Blood Res Program, San Antonio, TX USA. RP Campbell, JE (reprint author), 59MDW ST Wilford Hall Ambulatory Surg Ctr, Joint Inflammat Modulat Trauma Program JIMoT, Chief Scientist Off, 2200 Berquist Dr, San Antonio, TX 78236 USA. EM james.campbell.84.ctr@us.af.mil FU US Army Medical Research and Materiel Command, Fort Detrick; MD-US Institute for Surgical Research, Fort Sam Houston, San Antonio, TX [B_040_2011_USAISR] FX Funding for this work was provided by US Army Medical Research and Materiel Command, Fort Detrick, MD-US Institute for Surgical Research, Fort Sam Houston, San Antonio, TX Proposal B_040_2011_USAISR, PI (to J.E.C.). The authors declare no conflicts of interest. NR 35 TC 5 Z9 5 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD MAY PY 2015 VL 78 IS 5 BP 955 EP 961 DI 10.1097/TA.0000000000000586 PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA CH3KR UT WOS:000353930100009 PM 25909415 ER PT J AU Heegard, KD Stewart, IJ Cap, AP Sosnov, JA Kwan, HK Glass, KR Morrow, BD Latack, W Henderson, AT Saenz, KK Siew, ED Ikizler, TA Chung, KK AF Heegard, Kelly D. Stewart, Ian J. Cap, Andrew P. Sosnov, Jonathan A. Kwan, Hana K. Glass, Kristen R. Morrow, Benjamin D. Latack, Wayne Henderson, Aaron T. Saenz, Kristin K. Siew, Edward D. Ikizler, T. Alp Chung, Kevin K. TI Early acute kidney injury in military casualties SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Acute kidney injury; trauma; war; lactate; Injury Severity Score ID GLOMERULAR-FILTRATION-RATE; INTENSIVE-CARE-UNIT; ACUTE-RENAL-FAILURE; ILL TRAUMA PATIENTS; LONG-TERM RISK; SERUM CREATININE; MULTICENTER EVALUATION; CONTEMPORARY ANALYSIS; RIFLE CRITERIA; MORTALITY AB BACKGROUND: While acute kidney injury (AKI) has been well studied in a variety of patient settings, there is a paucity of data in patients injured in the course of the recent wars in Iraq and Afghanistan. We sought to establish the rate of early AKI in this population and to define risk factors for its development. METHODS: We combined the results of two studies performed at combat support hospitals in Afghanistan. Only US service members who required care in the intensive care unit were included for analysis. Data on age, race, sex, Injury Severity Score (ISS), first available lactate, and requirement for massive transfusion were collected. Univariate analyses were performed to identify factors associated with the subsequent development of early AKI. Multivariable Cox regression was used to adjust for potential confounders. RESULTS: The two observational cohorts yielded 134 subjects for analysis. The studies had broadly similar populations but differed in terms of age and need for massive transfusion. The rate of early AKI in the combined cohort was 34.3%, with the majority (80.5%) occurring within the first two hospital days. Patients with AKI had higher unadjusted mortality rates than those without AKI (21.7% vs. 2.3%, p < 0.001). After adjustment, ISS (hazard ratio, 1.02; 95% confidence interval, 1.00-1.03; p = 0.046) and initial lactate (hazard ratio, 1.16; 95% confidence interval, 1.03-1.31; p = 0.015) were independently associated with the development of AKI. CONCLUSION: AKI is common in combat casualties enrolled in two prospective intensive care unit studies, occurring in 34.3%, and is associated with crude mortality. ISS and initial lactate are independently associated with the subsequent development of early AKI. (J Trauma Acute Care Surg. 2015; 78: 988-993. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved.) C1 [Heegard, Kelly D.] Eglin Hosp, Dept Med, Eglin AFB, FL USA. [Stewart, Ian J.; Sosnov, Jonathan A.; Kwan, Hana K.; Glass, Kristen R.; Morrow, Benjamin D.; Henderson, Aaron T.; Saenz, Kristin K.] San Antonio Mil Med Ctr, Dept Med, Ft Sam Houston, TX 78234 USA. [Chung, Kevin K.] US Army Inst Surg Res, Burn Ctr, Ft Sam Houston, TX USA. [Cap, Andrew P.] US Army Inst Surg Res, Blood Task Area, Ft Sam Houston, TX USA. [Latack, Wayne] Kessler Med Ctr, Dept Med, Biloxi, MS USA. [Siew, Edward D.; Ikizler, T. Alp] Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN USA. [Stewart, Ian J.; Sosnov, Jonathan A.; Glass, Kristen R.; Morrow, Benjamin D.; Chung, Kevin K.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. RP Stewart, IJ (reprint author), San Antonio Mil Med Ctr, ATTN Nephrol, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM ian.j.stewart6.mil@mail.mil FU Air Force Medical Support Agency [EC-I-12-003]; US Army Medical Research and Materiel Command FX The UB trial was funded by the Air Force Medical Support Agency (EC-I-12-003). The DCR trial was funded by the US Army Medical Research and Materiel Command. NR 36 TC 3 Z9 3 U1 3 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD MAY PY 2015 VL 78 IS 5 BP 988 EP 993 DI 10.1097/TA.0000000000000607 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA CH3KR UT WOS:000353930100014 PM 25909420 ER PT J AU Burgess, E AF Burgess, Edwin TI The Hidden History of America at War: Untold Tales from Yorktown to Fallujah SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin] US Army, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. RP Burgess, E (reprint author), US Army, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD MAY 1 PY 2015 VL 140 IS 8 BP 88 EP 88 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA CH3ND UT WOS:000353936500159 ER PT J AU Burgess, E AF Burgess, Edwin TI Legend: A Harrowing Story from the Vietnam War of One Green Beret's Heroic Mission To Rescue a Special Forces Team Caught Behind Enemy Lines SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin] US Army, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. RP Burgess, E (reprint author), US Army, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 1 U2 1 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD MAY 1 PY 2015 VL 140 IS 8 BP 88 EP 88 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA CH3ND UT WOS:000353936500157 ER PT J AU Senchak, AJ McKinlay, AJ Acevedo, J Swain, B Tiu, MC Chen, BS Robitschek, J Ruhl, DS Williams, LL Camacho, M Frey, WC O'Connor, PD AF Senchak, Andrew J. McKinlay, Alex J. Acevedo, Jason Swain, Brenda Tiu, Maitram Christine Chen, Brian S. Robitschek, Jon Ruhl, Douglas S. Williams, Lawrence L. Camacho, Macario Frey, William C. O'Connor, Peter D. TI The Effect of Tonsillectomy Alone in Adult Obstructive Sleep Apnea SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article DE tonsillectomy; tonsils; adult; obstructive sleep apnea ID UPPER AIRWAY; ADENOTONSILLECTOMY; CHILDREN AB Objective The purpose of this study was to determine the effect of tonsillectomy as a single procedure in the treatment of adult obstructive sleep apnea (OSA). Study Design Prospective multi-institutional study evaluating adults with tonsillar hypertrophy scheduled to undergo tonsillectomy as an isolated surgery. Setting Tertiary care medical centers within the US Department of Defense. Subjects and Methods Adult subjects with tonsillar hypertrophy who were already scheduled for tonsillectomy were enrolled from October 2010 to July 2013. Subjects underwent physical examination, Epworth Sleepiness Scale, Berlin Questionnaire, and polysomnogram before surgery and after. Collected data included demographics, questionnaire scores, apnea-hypopnea index (AHI), and lowest saturation of oxygen. Results A total of 202 consecutive subjects undergoing tonsillectomy were enrolled. The final analysis included 19 subjects testing positive for OSA. The mean age was 27.9 years; mean body mass index, 29.6; median tonsil size, 3; and most frequent Friedman stage, 1. The AHI before surgery ranged from 5.4 to 56.4 events per hour. The mean AHI decreased from 18.0 to 3.2 events per hour after surgery, a reduction of 82%. The responder ratewith subjects achieving at least a 50% reduction of AHI to a value <15was 94.7%. Following tonsillectomy, there were statistically significant reductions in median lowest saturation of oxygen level and Epworth Sleepiness Scale and Berlin scores. Conclusions Adult tonsillectomy alone has beneficial effect in OSA management, particularly in young overweight men with large tonsils, moderate OSA, and low Friedman stage. C1 [Senchak, Andrew J.; Williams, Lawrence L.] Walter Reed Natl Mil Med Ctr, Bethesda, MD 20889 USA. [McKinlay, Alex J.] Darnall Army Med Ctr, Ft Hood, TX USA. [Acevedo, Jason; Swain, Brenda] Reynolds Army Community Hosp, Ft Sill, OK USA. [Tiu, Maitram Christine; Chen, Brian S.] Madigan Army Med Ctr, Tacoma, WA 98431 USA. [Robitschek, Jon] Landstuhl Reg Med Ctr, Landstuhl, Germany. [Ruhl, Douglas S.; Camacho, Macario] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Frey, William C.; O'Connor, Peter D.] San Antonio Mil Med Ctr, San Antonio, TX USA. RP Senchak, AJ (reprint author), Walter Reed Natl Mil Med Ctr, Dept Otolaryngol, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. EM Andrew.j.senchak.mil@mail.mil OI Camacho, Macario/0000-0001-9200-9085 FU AMEDD Advanced Medical Technology Initiative of the Telemedicine & Advanced Technology Research Center, Fort Detrick, Maryland FX Funding source: This work was supported by funds from the AMEDD Advanced Medical Technology Initiative of the Telemedicine & Advanced Technology Research Center, Fort Detrick, Maryland. These funds were used for the salary for a research coordinator and to purchase sleep apnea monitors and disposable equipment used with the monitors. NR 15 TC 6 Z9 6 U1 1 U2 1 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0194-5998 EI 1097-6817 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD MAY PY 2015 VL 152 IS 5 BP 969 EP 973 DI 10.1177/0194599815575721 PG 5 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA CH8BR UT WOS:000354261400033 PM 25820584 ER PT J AU Dadsetan, M Guda, T Runge, MB Mijares, D LeGeros, RZ LeGeros, JP Silliman, DT Lu, LC Wenke, JC Baer, PRB Yaszemski, MJ AF Dadsetan, Mahrokh Guda, Teja Runge, M. Brett Mijares, Dindo LeGeros, Racquel Z. LeGeros, John P. Silliman, David T. Lu, Lichun Wenke, Joseph C. Baer, Pamela R. Brown Yaszemski, Michael J. TI Effect of calcium phosphate coating and rhBMP-2 on bone regeneration in rabbit calvaria using poly(propylene fumarate) scaffolds SO ACTA BIOMATERIALIA LA English DT Article DE Bone regeneration; Poly(propylene fumarate); Calcium phosphate coating; Rabbit calvarial defect; 3-D printing ID CONTROLLED-PORE STRUCTURES; IN-VITRO; COMPOSITE SCAFFOLDS; PHYSICAL-PROPERTIES; CERAMICS; ADSORPTION; SURFACE; BMP-2; FABRICATION; IMPLANTS AB Various calcium phosphate based coatings have been evaluated for better bony integration of metallic implants and are currently being investigated to improve the surface bioactivity of polymeric scaffolds. The aim of this study was to evaluate the role of calcium phosphate coating and simultaneous delivery of recombinant human bone morphogenetic protein-2 (rhBMP-2) on the in vivo bone regeneration capacity of biodegradable, porous poly(propylene fumarate) (PPF) scaffolds. PPF scaffolds were coated with three different calcium phosphate formulations: magnesium-substituted beta-tricalcium phosphate (beta-TCMP), carbonated hydroxyapatite (synthetic bone mineral, SBM) and biphasic calcium phosphate (BCP). In vivo bone regeneration was evaluated by implantation of scaffolds in a critical-sized rabbit calvarial defect loaded with different doses of rhBMP-2. Our data demonstrated that scaffolds with each of the calcium phosphate coatings were capable of sustaining rhBMP-2 release and retained an open porous structure. After 6 weeks of implantation, micro-computed tomography revealed that the rhBMP-2 dose had a significant effect on bone formation within the scaffolds and that the SBM-coated scaffolds regenerated significantly greater bone than BCP-coated scaffolds. Mechanical testing of the defects also indicated restoration of strength in the SBM and beta-TCMP with rhBMP-2 delivery. Histology results demonstrated bone growth immediately adjacent to the scaffold surface, indicating good osteointegration and osteoconductivity for coated scaffolds. The results obtained in this study suggest that the coated scaffold platform demonstrated a synergistic effect between calcium phosphate coatings and rhBMP-2 delivery and may provide a promising platform for the functional restoration of large bone defects. (C) 2015 Published by Elsevier Ltd. on behalf of Acta Materialia Inc. C1 [Dadsetan, Mahrokh; Runge, M. Brett; Lu, Lichun; Yaszemski, Michael J.] Mayo Clin, Biomat & Tissue Engn Lab, Rochester, MN 55905 USA. [Guda, Teja] Univ Texas San Antonio, Dept Biomed Engn, San Antonio, TX USA. [Mijares, Dindo; LeGeros, Racquel Z.; LeGeros, John P.] NYU, Dept Biomat & Biomimet, New York, NY USA. [Silliman, David T.; Wenke, Joseph C.; Baer, Pamela R. Brown] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Yaszemski, MJ (reprint author), Mayo Clin, Biomat & Tissue Engn Lab, Rochester, MN 55905 USA. EM yaszemski.michael@mayo.edu OI Brown Baer, Pamela/0000-0001-6964-1955 FU Mayo Foundation; NIH [R01 EB03060]; Armed Forces Institute of Regenerative Medicine [W81XWH-08-2-0034] FX This work was supported by the Mayo Foundation, NIH grant R01 EB03060 and Armed Forces Institute of Regenerative Medicine award number W81XWH-08-2-0034. NR 57 TC 8 Z9 8 U1 7 U2 59 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1742-7061 EI 1878-7568 J9 ACTA BIOMATER JI Acta Biomater. PD MAY PY 2015 VL 18 BP 9 EP 20 DI 10.1016/j.actbio.2014.12.024 PG 12 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA CG8ZX UT WOS:000353605300002 PM 25575855 ER PT J AU Dailey, JI Warner, CH AF Dailey, Jason I. Warner, Christopher H. TI The 2,000 Yard Stare SO AMERICAN JOURNAL OF PSYCHIATRY LA English DT Editorial Material C1 [Dailey, Jason I.; Warner, Christopher H.] US Army, Med Detachment Combat & Operat Stress Control & A, Ft Campbell, KY 42223 USA. RP Dailey, JI (reprint author), US Army, Med Detachment Combat & Operat Stress Control & A, Ft Campbell, KY 42223 USA. EM jason.i.dailey@us.army.mil NR 2 TC 0 Z9 0 U1 0 U2 0 PU AMER PSYCHIATRIC PUBLISHING, INC PI ARLINGTON PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA SN 0002-953X EI 1535-7228 J9 AM J PSYCHIAT JI Am. J. Psychiat. PD MAY PY 2015 VL 172 IS 5 BP 425 EP 425 DI 10.1176/appi.ajp.2014.13121682 PG 1 WC Psychiatry SC Psychiatry GA CH2FM UT WOS:000353841100008 PM 25930133 ER PT J AU Kennedy, JE Cooper, DB Reid, MW Tate, DF Lange, RT AF Kennedy, Jan E. Cooper, Douglas B. Reid, Matthew W. Tate, David F. Lange, Rael T. TI Profile Analyses of the Personality Assessment Inventory Following Military-Related Traumatic Brain Injury SO ARCHIVES OF CLINICAL NEUROPSYCHOLOGY LA English DT Article DE Traumatic brain injury; Personality assessment inventory; Postconcussion; Military; Cluster analysis ID POSTTRAUMATIC-STRESS-DISORDER; PERSISTENT POSTCONCUSSIVE SYMPTOMS; PTSD CHECKLIST PCL; PSYCHOMETRIC PROPERTIES; ENDURING FREEDOM; IRAQI FREEDOM; RISK-FACTORS; HEAD-INJURY; VETERANS; HEALTH AB Personality Assessment Inventory (PAI) profiles were examined in 160 U.S. service members (SMs) following mild-severe traumatic brain injury (TBI). Participants who sustained a mild TBI had significantly higher PAI scores than those with moderate-severe TBI on eight of the nine clinical scales examined. A two-step cluster analysis identified four PAI profiles, heuristically labeled "High Distress", "Moderate Distress", "Somatic Distress," and "No Distress". Postconcussive and posttraumatic stress symptom severity was highest for the High Distress group, followed by the Somatic and Moderate Distress groups, and the No Distress group. Profile groups differed in age, ethnicity, rank, and TBI severity. Findings indicate that meaningful patterns of behavioral and personality characteristics can be detected in active duty military SMs following TBI, which may prove useful in selecting the most efficacious rehabilitation strategies. C1 [Kennedy, Jan E.; Cooper, Douglas B.; Reid, Matthew W.; Tate, David F.] San Antonio Mil Med Ctr, Def & Vet Brain Injury Ctr, Ft Sam Houston, TX USA. [Lange, Rael T.] Walter Reed Natl Mil Med Ctr, Def & Vet Brain Injury Ctr, Bethesda, MD USA. [Lange, Rael T.] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada. RP Kennedy, JE (reprint author), Brooke Army Med Ctr, MCHE MDU DVBIC, 3551 Roger Brooke Dr, Jbsa Ft Sam Houston, TX 78234 USA. EM jan.e.kennedy2.ctr@mail.mil RI Tate, David/I-3963-2013 FU Defense and Veterans Brain Injury Center; Henry M. Jackson Foundation for the Advancement of Military Medicine and General Dynamics Information Technology FX This work was supported by the Defense and Veterans Brain Injury Center and the Henry M. Jackson Foundation for the Advancement of Military Medicine and General Dynamics Information Technology. NR 54 TC 0 Z9 0 U1 1 U2 7 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0887-6177 EI 1873-5843 J9 ARCH CLIN NEUROPSYCH JI Arch. Clin. Neuropsychol. PD MAY PY 2015 VL 30 IS 3 BP 236 EP 247 DI 10.1093/arclin/acv014 PG 12 WC Psychology, Clinical; Psychology SC Psychology GA CH1ZO UT WOS:000353822600008 PM 25857403 ER PT J AU Liu, G Song, LZ Beasley, DWC Putnak, R Parent, J Misczak, J Li, H Reiserova, L Liu, XY Tian, HJ Liu, WZ Labonte, D Duan, LH Kim, Y Travalent, L Wigington, D Weaver, B Tussey, L AF Liu, Ge Song, Langzhou Beasley, David W. C. Putnak, Robert Parent, Jason Misczak, John Li, Hong Reiserova, Lucia Liu, Xiangyu Tian, Haijun Liu, Wenzhe Labonte, Darlene Duan, Lihua Kim, Youngsun Travalent, Linda Wigington, Devin Weaver, Bruce Tussey, Lynda TI Immunogenicity and Efficacy of Flagellin-Envelope Fusion Dengue Vaccines in Mice and Monkeys SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID DOMAIN-III; IMMUNE-RESPONSE; VIRUS TYPE-2; NEUTRALIZING ANTIBODIES; MONOCLONAL-ANTIBODIES; RECOMBINANT SUBUNIT; PROTECTIVE EFFICACY; NONHUMAN-PRIMATES; RHESUS-MONKEYS; VERO CELLS AB The envelope (E) protein of flaviviruses includes three domains, EI, EII, and EIII, and is the major protective antigen. Because EIII is rich in type-specific and subcomplex-specific neutralizing epitopes and is easy to express, it is particularly attractive as a recombinant vaccine antigen. VaxInnate has developed a vaccine platform that genetically links vaccine antigens to bacterial flagellin, a Toll-like receptor 5 ligand. Here we report that tetravalent dengue vaccines (TDVs) consisting of four constructs, each containing two copies of EIII fused to flagellin (R3.2x format), elicited robust and long-lived neutralizing antibodies (geometric mean titers of 200 to 3,000), as measured with a 50% focus reduction neutralization test (FRNT50). In an immunogenicity study, rhesus macaques (n = 2) immunized subcutaneously with 10 mu g or 90 mu g of TDV three or four times, at 4- to 6-week intervals, developed neutralizing antibodies to four dengue virus (DENV) serotypes (mean post-dose 3 FRNT50 titers of 102 to 601). In an efficacy study, rhesus macaques (n = 4) were immunized intramuscularly with 16 mu g or 48 mu g of TDV or a placebo control three times, at 1-month intervals. The animals that received 48-mu g doses of TDV developed neutralizing antibodies against the four serotypes (geometric mean titers of 49 to 258) and exhibited reduced viremia after DENV-2 challenge, with a group mean viremia duration of 1.25 days and 2 of 4 animals being completely protected, compared to the placebo-treated animals, which all developed viremia, with a mean duration of 4 days. In conclusion, flagellin-EIII fusion vaccines are immunogenic and partially protective in a nonhuman primate model. C1 [Liu, Ge; Song, Langzhou; Parent, Jason; Misczak, John; Li, Hong; Reiserova, Lucia; Liu, Xiangyu; Tian, Haijun; Liu, Wenzhe; Labonte, Darlene; Duan, Lihua; Kim, Youngsun; Travalent, Linda; Wigington, Devin; Weaver, Bruce; Tussey, Lynda] VaxInnate Corp, Cranbury, NJ 08512 USA. [Beasley, David W. C.] Univ Texas Med Branch, Dept Microbiol & Immunol, Sealy Ctr Vaccine Dev, Galveston, TX 77555 USA. [Beasley, David W. C.] Univ Texas Med Branch, Galveston Natl Lab, Galveston, TX 77555 USA. [Putnak, Robert] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD USA. RP Liu, G (reprint author), VaxInnate Corp, Cranbury, NJ 08512 USA. EM ge.liu@vaxinnate.com NR 46 TC 4 Z9 4 U1 3 U2 4 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 EI 1556-679X J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD MAY PY 2015 VL 22 IS 5 BP 516 EP 525 DI 10.1128/CVI.00770-14 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA CG8OS UT WOS:000353568300008 PM 25761459 ER PT J AU Sheffield, BM Schuchman, G Bernstein, JGW AF Sheffield, Benjamin M. Schuchman, Gerald Bernstein, Joshua G. W. TI Trimodal Speech Perception: How Residual Acoustic Hearing Supplements Cochlear-Implant Consonant Recognition in the Presence of Visual Cues SO EAR AND HEARING LA English DT Article DE Auditory-visual; Bimodal; Cochlear implant; Consonant; Phonetic information; Trimodal ID ARTICULATION INDEX; ELECTRIC HEARING; BIMODAL HEARING; OPPOSITE EARS; USERS; CHILDREN; AID; STIMULATION; BENEFITS; ADULTS AB Objectives: As cochlear implant (CI) acceptance increases and candidacy criteria are expanded, these devices are increasingly recommended for individuals with less than profound hearing loss. As a result, many individuals who receive a CI also retain acoustic hearing, often in the low frequencies, in the nonimplanted ear (i.e., bimodal hearing) and in some cases in the implanted ear (i.e., hybrid hearing) which can enhance the performance achieved by the CI alone. However, guidelines for clinical decisions pertaining to cochlear implantation are largely based on expectations for postsurgical speech-reception performance with the CI alone in auditory-only conditions. A more comprehensive prediction of postimplant performance would include the expected effects of residual acoustic hearing and visual cues on speech understanding. An evaluation of auditory-visual performance might be particularly important because of the complementary interaction between the speech information relayed by visual cues and that contained in the low-frequency auditory signal. The goal of this study was to characterize the benefit provided by residual acoustic hearing to consonant identification under auditory-alone and auditory-visual conditions for CI users. Additional information regarding the expected role of residual hearing in overall communication performance by a CI listener could potentially lead to more informed decisions regarding cochlear implantation, particularly with respect to recommendations for or against bilateral implantation for an individual who is functioning bimodally. Design: Eleven adults 23 to 75 years old with a unilateral CI and air-conduction thresholds in the nonimplanted ear equal to or better than 80 dB HL for at least one octave frequency between 250 and 1000 Hz participated in this study. Consonant identification was measured for conditions involving combinations of electric hearing (via the CI), acoustic hearing (via the nonimplanted ear), and speechreading (visual cues). Results: The results suggest that the benefit to CI consonant-identification performance provided by the residual acoustic hearing is even greater when visual cues are also present. An analysis of consonant confusions suggests that this is because the voicing cues provided by the residual acoustic hearing are highly complementary with the mainly place-of-articulation cues provided by the visual stimulus. Conclusions: These findings highlight the need for a comprehensive prediction of trimodal (acoustic, electric, and visual) postimplant speech-reception performance to inform implantation decisions. The increased influence of residual acoustic hearing under auditory-visual conditions should be taken into account when considering surgical procedures or devices that are intended to preserve acoustic hearing in the implanted ear. This is particularly relevant when evaluating the candidacy of a current bimodal CI user for a second CI (i.e., bilateral implantation). Although recent developments in CI technology and surgical techniques have increased the likelihood of preserving residual acoustic hearing, preservation cannot be guaranteed in each individual case. Therefore, the potential gain to be derived from bilateral implantation needs to be weighed against the possible loss of the benefit provided by residual acoustic hearing. C1 [Sheffield, Benjamin M.; Schuchman, Gerald; Bernstein, Joshua G. W.] Walter Reed Natl Mil Med Ctr, Natl Mil Audiol & Speech Pathol Ctr, Bethesda, MD 20889 USA. [Sheffield, Benjamin M.] US Army Publ Hlth Command, Aberdeen, MD USA. RP Sheffield, BM (reprint author), Walter Reed Natl Mil Med Ctr, Natl Mil Audiol & Speech Pathol Ctr, Amer Bldg,5th Floor,4954 North Palmer Rd, Bethesda, MD 20889 USA. EM benjamin.m.sheffield.civ@mail.mil FU Defense Health Affairs FX Funding was received by Defense Health Affairs in support of the Army Hearing Program. NR 42 TC 4 Z9 4 U1 1 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0196-0202 EI 1538-4667 J9 EAR HEARING JI Ear Hear. PD MAY-JUN PY 2015 VL 36 IS 3 BP E99 EP E112 PG 14 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA CG8SC UT WOS:000353581000006 PM 25514796 ER PT J AU Tillman, ED AF Tillman, Ellen D. TI Militarizing Dollar Diplomacy in the Early Twentieth-Century Dominican Republic: Centralization and Resistance SO HAHR-HISPANIC AMERICAN HISTORICAL REVIEW LA English DT Article AB In the early 1900s, the US government experimented with what they saw as a progressive style of influence in the Dominican Republic. While the Roosevelt and Taft administrations sought alternatives to armed intervention, US officers serving as diplomats pushed for more direct military control, through projects such as the creation of a US-officered frontier guard. Established in 1905 to police revenue along the Dominican-Haitian border, this unique organization had neither precedent nor sanction in international law, but it demonstrated the makeshift Caribbean policy of an expanding United States and how this expansion gradually militarized diplomacy. Paternalist discourse and rapid economic change perpetuated internal strife, eventually contributing to bloody civil war and outright US military occupation (1916-1924). This article explores the development of the frontier guard and interventionism, focusing on the roles of Dominican economic and political change and contemporary US expansionist ideology, with its goal of exporting US-style democratic institutions. C1 [Tillman, Ellen D.] US Mil Acad, West Point, NY USA. RP Tillman, ED (reprint author), Texas State Univ, Dept Hist, Mil Hist & Modern Hist Amer, San Marcos, TX 78666 USA. NR 32 TC 1 Z9 1 U1 0 U2 2 PU DUKE UNIV PRESS PI DURHAM PA 905 W MAIN ST, STE 18-B, DURHAM, NC 27701 USA SN 0018-2168 EI 1527-1900 J9 HAHR-HISP AM HIST R JI HAHR-Hisp. Am. Hist. Rev. PD MAY PY 2015 VL 95 IS 2 BP 269 EP 297 DI 10.1215/00182168-2870788 PG 29 WC History SC History GA CG9UF UT WOS:000353664900003 ER PT J AU Gajavelli, S Kentaro, S Diaz, J Yokobori, S Spurlock, M Diaz, D Jackson, C Wick, A Zhao, WZ Leung, LY Shear, D Tortella, F Bullock, MR AF Gajavelli, Shyam Kentaro, Shimoda Diaz, Julio Yokobori, Shoji Spurlock, Markus Diaz, Daniel Jackson, Clayton Wick, Alexandra Zhao, Weizhao Leung, Lai Y. Shear, Deborah Tortella, Frank Bullock, M. Ross TI Glucose and oxygen metabolism after penetrating ballistic-like brain injury SO JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM LA English DT Article DE 2-deoxy glucose; cerebral metabolism; Fluorojade B; glucose; neurodegeneration; oxygen ID ISCHEMIC PENUMBRA; GUNSHOT WOUNDS; UNITED-STATES; RAT MODEL; ACTIVATION; HEMORRHAGE; EXPRESSION; BIOMARKERS; SEVERITY AB Traumatic brain injury (TBI) is a major cause of death and disability in all age groups. Among TBI, penetrating traumatic brain injuries (PTBI) have the worst prognosis and represent the leading cause of TBI-related morbidity and death. However, there are no specific drugs/interventions due to unclear pathophysiology. To gain insights we looked at cerebral metabolism in a PTBI rat model: penetrating ballistic-like brain injury (PBBI). Early after injury, regional cerebral oxygen tension and consumption significantly decreased in the ipsilateral cortex in the PBBI group compared with the control group. At the same time point, glucose uptake was significantly reduced globally in the PBBI group compared with the control group. Examination of Fluorojade B-stained brain sections at 24 hours after PBBI revealed an incomplete overlap of metabolic impairment and neurodegeneration. As expected, the injury core had the most severe metabolic impairment and highest neurodegeneration. However, in the peri-lesional area, despite similar metabolic impairment, there was lesser neurodegeneration. Given our findings, the data suggest the presence of two distinct zones of primary injury, of which only one recovers. We anticipate the peri-lesional area encompassing the PBBI ischemic penumbra, could be salvaged by acute therapies. C1 [Gajavelli, Shyam; Kentaro, Shimoda; Diaz, Julio; Spurlock, Markus; Diaz, Daniel; Jackson, Clayton; Wick, Alexandra; Zhao, Weizhao; Bullock, M. Ross] Univ Miami, Miller Sch Med, Dept Neurosurg, Miami, FL 33136 USA. [Yokobori, Shoji] Nippon Med Sch, Dept Emergency & Crit Care Med, Tokyo 113, Japan. [Leung, Lai Y.; Shear, Deborah; Tortella, Frank] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect & Neurorestorat, Silver Spring, MD USA. RP Bullock, MR (reprint author), Univ Miami, Miller Sch Med, Dept Neurosurg, Lois Pope LIFE Ctr, Room 3-20,1095 NW 14th Terrace, Miami, FL 33136 USA. EM RBullock@med.miami.edu FU Department of Defense [PT074521W81XWH-08-1-0419] FX This work was supported by Department of Defense Grant #PT074521W81XWH-08-1-0419 to RB. NR 40 TC 3 Z9 3 U1 0 U2 3 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0271-678X EI 1559-7016 J9 J CEREBR BLOOD F MET JI J. Cereb. Blood Flow Metab. PD MAY PY 2015 VL 35 IS 5 BP 773 EP 780 DI 10.1038/jcbfm.2014.243 PG 8 WC Endocrinology & Metabolism; Hematology; Neurosciences SC Endocrinology & Metabolism; Hematology; Neurosciences & Neurology GA CH1GK UT WOS:000353769100012 PM 25669903 ER PT J AU Dubey, JP Sykes, JE Shelton, GD Sharp, N Verma, SK Calero-Bernal, R Viviano, J Sundar, N Khan, A Grigg, ME AF Dubey, Jitender P. Sykes, Jane E. Shelton, G. Diane Sharp, Nick Verma, Shiv K. Calero-Bernal, Rafael Viviano, Jenifer Sundar, Natarajan Khan, Asis Grigg, Michael E. TI Sarcocystis caninum and Sarcocystis svanai n. spp. (Apicomplexa: Sarcocystidae) Associated with Severe Myositis and Hepatitis in the Domestic Dog (Canis familiaris) SO JOURNAL OF EUKARYOTIC MICROBIOLOGY LA English DT Article DE Canada; dog; USA ID BEARS URSUS-MARITIMUS; MUSCULAR SARCOCYSTOSIS; NEURONA; ENCEPHALITIS; INFECTION; SCHIZONTS; PARASITE AB There are several reports of Sarcocystis sarcocysts in muscles of dogs, but these species have not been named. Additionally, there are two reports of Sarcocystis neurona in dogs. Here, we propose two new names, Sarcocystis caninum, and Sarcocystis svanai for sarcocysts associated with clinical muscular sarcocystosis in four domestic dogs (Canis familiaris), one each from Montana and Colorado in the USA, and two from British Columbia, Canada. Only the sarcocyst stage was identified. Most of the sarcocysts identified were S. caninum. Sarcocysts were studied using light microscopy, transmission electron microscopy (TEM), and polymerase chain reaction. Based on collective results two new species, S. caninum and S. svanai were designated. Sarcocystis caninum and S. svanai were structurally distinct. Sarcocystis caninum sarcocysts were up to 1.2mm long and up to 75m wide. By light microscopy, the sarcocyst wall was relatively thin and smooth. By TEM, the sarcocyst wall was type 9, 1-2m thick, and contained villar protrusions that lacked microtubules. Bradyzoites in sections were 7-9m long. Sarcocysts of S. svanai were few and were identified by TEM. Sarcocystis svanai sarcocysts were type 1, thin walled (<0.5m), and the wall lacked villar protrusions but had tiny blebs that did not invaginate. DNA was extracted either from infected frozen muscle biopsies or formalin-fixed paraffin-embedded sections. Dogs were either singly infected with S. caninum or multiply co-infected with S. caninum and S. svanai (the result of a mixed infection) based on multilocus DNA sequencing and morphology. BLASTn analysis established that the sarcocysts identified in these dogs were similar to, but not identical to Sarcocystis canis or Sarcocystis arctosi, parasites found to infect polar bears (Ursus maritimus) or brown bears (Ursus arctosi), respectively. However, the S. caninum sequence showed 100% identify over the 18S rRNA region sequenced to that of S. arctica, a parasite known to infect Arctic foxes (Vulpes lagopus). C1 [Dubey, Jitender P.; Verma, Shiv K.; Calero-Bernal, Rafael] ARS, Anim Parasit Dis Lab, USDA, Beltsville Agr Res Ctr, Beltsville, MD 20705 USA. [Sykes, Jane E.] Univ Calif Davis, Sch Vet Med, Dept Med & Epidemiol, Davis, CA 95616 USA. [Shelton, G. Diane] Univ Calif San Diego, Dept Pathol, La Jolla, CA 92093 USA. [Sharp, Nick] Canada West Vet Specialists, Vancouver, BC V6R 1E5, Canada. [Viviano, Jenifer] US Army, Joint Pathol Ctr, Vet Pathol Serv, Silver Spring, MD 20910 USA. [Sundar, Natarajan; Khan, Asis; Grigg, Michael E.] NIAID, Mol Parasitol Sect, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA. RP Dubey, JP (reprint author), BARC, Anim Parasit Dis Lab, USDA, Bldg 1001, Beltsville, MD 20705 USA. EM jitender.dubey@ars.usda.gov FU NIH; NIAID; Department of Employment and Innovation of the Regional Government of Extremadura, Spain [PO12010]; European Social Fund [PO12010] FX The authors thank Dr. Eric Hoberg for his helpful suggestions concerning taxonomy, and Mr. Efrain Perez, Joint Pathology Center, Veterinary Services, U.S. Army, Silver Spring, Maryland for excellent technical help with electron microscopy. This study was financially support in part by the Intramural Research Program of the NIH and NIAID. M.E.G. is a scholar of the Canadian Institute for Advanced Research Integrated Microbial Biodiversity Program.; R. Calero-Bernal is a postdoctoral fellow (ref. PO12010) funded by the Department of Employment and Innovation of the Regional Government of Extremadura, Spain and the European Social Fund. NR 24 TC 2 Z9 2 U1 0 U2 8 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1066-5234 EI 1550-7408 J9 J EUKARYOT MICROBIOL JI J. Eukaryot. Microbiol. PD MAY-JUN PY 2015 VL 62 IS 3 BP 307 EP 317 DI 10.1111/jeu.12182 PG 11 WC Microbiology SC Microbiology GA CG8IQ UT WOS:000353551300004 PM 25256157 ER PT J AU Weber, NS Larsen, RA Yolken, RH Cowan, DN Boivin, MR Niebuhr, DW AF Weber, Natalya S. Larsen, Rakel A. Yolken, Robert H. Cowan, David N. Boivin, Michael R. Niebuhr, David W. TI Predictors of the Onset of Schizophrenia in US Military Personnel SO JOURNAL OF NERVOUS AND MENTAL DISEASE LA English DT Article DE Psychosis; bipolar; immune response; pentraxin-3; biomarker ID C-REACTIVE PROTEIN; LONG PENTRAXIN PTX3; BIPOLAR DISORDER; SERUM-LEVELS; IMMUNE-SYSTEM; INDIVIDUALS; ANTIBODIES; PSYCHOSIS; INFLAMMATION; CYTOKINES AB Alterations in immune response may be an important component in the etiopathogenesis of schizophrenia and bipolar disorder. We examined the associations of pentraxin-3 (PTX3) with the onset of schizophrenia or bipolar disorder. We tested preonset serum specimens from 160 US military service members who were later diagnosed with schizophrenia or bipolar disorder and 160 matched controls without psychiatric disorders. Lower serum levels of PTX3 were predictive of schizophrenia but not of bipolar disorder. Subjects with below-median PTX3 levels had a 3.0 odds ratio (confidence interval, 1.6-5.7) for schizophrenia onset in the multivariable logistic regression model controlling for demographic and military variables. The test for trends was significant (p = 0.002), with the likelihood increasing as the levels of PTX3 decreased. Crude and adjusted categorized levels were not predictive of bipolar disorder. A lower level of inflammatory response indicated by PTX3 might be implicated in developing schizophrenia. C1 [Weber, Natalya S.; Larsen, Rakel A.; Cowan, David N.; Boivin, Michael R.; Niebuhr, David W.] Walter Reed Army Inst Res, Prevent Med Branch, Silver Spring, MD 20910 USA. [Larsen, Rakel A.; Cowan, David N.] ManTech Hlth, Herndon, VA USA. [Yolken, Robert H.] Johns Hopkins Univ, Sch Med, Dept Pediat, Stanley Div Dev Neurovirol, Baltimore, MD 21205 USA. [Niebuhr, David W.] Uniformed Serv Univ Hlth Sci, Div Epidemiol & Biostat, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. RP Weber, NS (reprint author), Walter Reed Army Inst Res, Prevent Med Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Natalya.S.Weber.CIV@mail.mil FU Stanley Medical Research Institute, Bethesda, MD [03-NV-005]; Department of the Army FX This work was supported by the Stanley Medical Research Institute, Bethesda, MD (research grant 03-NV-005) and the Department of the Army. NR 66 TC 2 Z9 2 U1 1 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0022-3018 EI 1539-736X J9 J NERV MENT DIS JI J. Nerv. Ment. Dis. PD MAY PY 2015 VL 203 IS 5 BP 319 EP 324 DI 10.1097/NMD.0000000000000285 PG 6 WC Clinical Neurology; Psychiatry SC Neurosciences & Neurology; Psychiatry GA CH0CO UT WOS:000353686800003 PM 25919381 ER PT J AU O'Hearn, A Wang, MX Cheng, H Lear-Rooney, CM Koning, K Rumschlag-Booms, E Varhegyi, E Olinger, G Rong, LJ AF O'Hearn, Aileen Wang, Minxiu Cheng, Han Lear-Rooney, Calli M. Koning, Katie Rumschlag-Booms, Emily Varhegyi, Elizabeth Olinger, Gene Rong, Lijun TI Role of EXT1 and Glycosaminoglycans in the Early Stage of Filovirus Entry SO JOURNAL OF VIROLOGY LA English DT Article ID SURFACE HEPARAN-SULFATE; HERPES-SIMPLEX-VIRUS; LAKE-VICTORIA-MARBURGVIRUS; NIEMANN-PICK C1; EBOLA-VIRUS; HEMORRHAGIC-FEVER; ZAIRE-EBOLAVIRUS; E2 GLYCOPROTEIN; CELLULAR ENTRY; VIRAL ENTRY AB Filoviruses, including both Ebola virus (EBOV) and Marburg virus (MARV), can infect humans and other animals, causing hemorrhagic fever with a high mortality rate. Entry of these viruses into the host is mediated by a single filoviral glycoprotein (GP). GP is composed of two subunits: GP1, which is responsible for attachment and binding to receptor(s) on susceptible cells, and GP2, which mediates viral and cell membrane fusion. Although numerous host factors have been implicated in the entry process, the initial attachment receptor(s) has not been well defined. In this report, we demonstrate that exostosin 1 (EXT1), which is involved in biosynthesis of heparan sulfate (HS), plays a role in filovirus entry. Expression knockdown of EXT1 by small interfering RNAs (siRNAs) impairs GP-mediated pseudoviral entry and that of infectious EBOV and MARV in tissue cultured cells. Furthermore, HS, heparin, and other related glycosaminoglycans (GAGs), to different extents, can bind to and block GP-mediated viral entry and that of infectious filoviruses. These results strongly suggest that HS and other related GAGs are attachment receptors that are utilized by filoviruses for entry and infection. These GAGs may have therapeutic potential in treating EBOV- and MARV-infected patients. IMPORTANCE Infection by Ebola virus and Marburg virus can cause severe illness in humans, with a high mortality rate, and currently there is no FDA-approved vaccine or therapeutic treatment available. The ongoing 2014 outbreak in West Africa underscores a lack of our understanding in the infection and pathogenesis of these viruses and the urgency of drug discovery and development. In this study, we provide several pieces of evidence that demonstrate that heparan sulfate and other closely related glycosaminoglycans are the molecules that are used by filoviruses for initial attachment. Furthermore, we demonstrate that these glycosaminoglycans can block entry of and infection by filoviruses. Thus, this work provides mechanistic insights on the early step of filoviral infection and suggests a possible therapeutic option for diseases caused by filovirus infection. C1 [O'Hearn, Aileen; Wang, Minxiu; Cheng, Han; Koning, Katie; Rumschlag-Booms, Emily; Varhegyi, Elizabeth; Rong, Lijun] Univ Illinois, Coll Med, Dept Microbiol & Immunol, Chicago, IL 60612 USA. [Lear-Rooney, Calli M.; Olinger, Gene] US Army Med Res Inst Infect Dis, Ft Detrick, MD USA. RP O'Hearn, A (reprint author), Univ Illinois, Coll Med, Dept Microbiol & Immunol, Chicago, IL 60612 USA. EM lijun@uic.edu FU National Institutes of Health [AI059570, AI77767] FX This research was partially supported by National Institutes of Health grants AI059570 and AI77767 to L.R. NR 41 TC 10 Z9 10 U1 0 U2 13 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X EI 1098-5514 J9 J VIROL JI J. Virol. PD MAY PY 2015 VL 89 IS 10 BP 5441 EP 5449 DI 10.1128/JVI.03689-14 PG 9 WC Virology SC Virology GA CG5KB UT WOS:000353329300024 PM 25741008 ER PT J AU Waterman, BR Cameron, KL Hsiao, M Langston, JR Clark, NJ Owens, BD AF Waterman, Brian R. Cameron, Kenneth L. Hsiao, Mark Langston, Joseph R. Clark, Nicholas J. Owens, Brett D. TI Trends in the diagnosis of SLAP lesions in the US military SO KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY LA English DT Article DE SLAP; Superior labrum; Epidemiology; Military ID SUPERIOR LABRUM ANTERIOR; GENDER-DIFFERENCES; GLENOID LABRUM; SHOULDER; POPULATION; PREVALENCE; OUTCOMES; REPAIRS AB Shoulder pathology, particularly SLAP (superior labrum anterior-posterior) lesions, is prevalent in overhead athletes and physically active individuals. The aim of this study is to quantify the burden of SLAP lesions in the military and establish risk factors for diagnosis. A retrospective analysis of all service members diagnosed with a SLAP lesion (International Classification of Disease, Ninth Revision code 840.70) in the Defense Medical Epidemiological Database between 2002 and 2009 was performed. Available epidemiological risk factors including age, sex, race, military rank, and branch of service were evaluated using multivariate Poisson regression analysis, and cumulative and subgroup incidence rates were calculated. During the study period, approximately 23,632 SLAP lesions were diagnosed among a population at risk of 11,082,738, resulting in an adjusted incidence rate of 2.13 per 1,000 person-years. The adjusted annual incidence rate for SLAP lesions increased from 0.31 cases per 1,000 person-years in 2002 to 1.88 cases per 1,000 person-years in 2009, with an average annual increase of 21.2 % (95 % CI 20.7 %, 22.0 %, p < 0.0001) during the study period. Age, sex, race, branch of military service, and military rank were independent risk factors associated with the incidence rate of SLAP lesion (p < 0.01). Male service members were over twofold more likely (IRR, 2.12; 95 % CI 2.01, 2.23) to sustain a SLAP lesion when compared with females. Increasing age category was associated with a statistically significant increase in the incidence rate for SLAP lesions in the present study (p < 0.001). After controlling for the other variables, those individuals of white race, enlisted ranks, or Marine Corps service experienced the highest incidence rates for SLAP. This is the first study to establish the epidemiology of SLAP lesions within an active military cohort in the American population. Sex, age, race, military rank, and branch of military service were all independently associated with the incidence rate of SLAP lesions in this physically active population at high risk for shoulder injury. II. C1 [Waterman, Brian R.; Hsiao, Mark] William Beaumont Army Med Ctr, Orthopaed Surg Serv, El Paso, TX 79920 USA. [Cameron, Kenneth L.; Owens, Brett D.] Keller Army Hosp, West Point, NY USA. [Langston, Joseph R.] Oregon Hlth & Sci Univ, Orthopaed & Rehabil, Portland, OR 97201 USA. [Clark, Nicholas J.] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. RP Waterman, BR (reprint author), William Beaumont Army Med Ctr, Orthopaed Surg Serv, 5005 North Piedras St, El Paso, TX 79920 USA. EM brian.r.waterman@gmail.com OI Cameron, Kenneth/0000-0002-6276-4482 NR 28 TC 3 Z9 3 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0942-2056 EI 1433-7347 J9 KNEE SURG SPORT TR A JI Knee Surg. Sports Traumatol. Arthrosc. PD MAY PY 2015 VL 23 IS 5 BP 1453 EP 1459 DI 10.1007/s00167-013-2798-z PG 7 WC Orthopedics; Sport Sciences; Surgery SC Orthopedics; Sport Sciences; Surgery GA CH2BP UT WOS:000353829500027 PM 24318507 ER PT J AU Ramsauer, K Schwameis, M Firbas, C Mullner, M Putnak, RJ Thomas, SJ Despres, P Tauber, E Jilma, B Tangy, F AF Ramsauer, Katrin Schwameis, Michael Firbas, Christa Muellner, Matthias Putnak, Robert J. Thomas, Stephen J. Despres, Philippe Tauber, Erich Jilma, Bernd Tangy, Frederic TI Immunogenicity, safety, and tolerability of a recombinant measles-virus-based chikungunya vaccine: a randomised, double-blind, placebo-controlled, active-comparator, first-in-man trial SO LANCET INFECTIOUS DISEASES LA English DT Article ID NEUTRALIZING ANTIBODIES; ENVELOPE GLYCOPROTEIN; IMMUNE-RESPONSES; PROTECTS MICE; DNA VACCINE; INFECTION; STRAIN; MORBIDITY; EPIDEMIC; OUTBREAK AB Background Chikungunya is an emerging arthropod-borne disease that has spread from tropical endemic areas to more temperate climates of the USA and Europe. However, no specific treatment or preventive measure is yet available. We aimed to investigate the immunogenicity and safety of a live recombinant measles-virus-based chikungunya vaccine. Methods We did a randomised, double-blind, placebo-controlled, active-comparator, phase 1, dose-escalation study at one centre in Vienna, Austria. Healthy men and women aged 18-45 years with no comorbidifies were randomly assigned, by computer-generated block randomisation (block size of 14), to receive either one of three escalating doses of the measles-virus-based candidate vaccine (low dose [1.5 x10(4) median tissue culture infection doses (TCID50) per 0.05 mL], medium dose [7.5 x 10(4) TCID50 per 0.25 mL], or high dose [3.0 x 10(5) TCID50 per 1.0 mL]), or the active comparator Priorix. Participants were additionally block-randomised to receive a booster injection on either day 28 or day 90 after the first vaccination. Participants and study investigators were masked to group allocation. The primary endpoint was the presence of neutralising anti-chikungunya antibodies on day 28, as assessed by 50% plaque reduction neutralisation test. Analysis was by intention to treat and per protocol. This trial is registered with EudraCT, number 2013-001084-23. Findings Between Nov 22, 2013, and Feb 25, 2014, we randomly assigned 42 participants to receive the low dose (n=12), the medium dose (n=12), or the high dose (n=12) of the measles-virus-based candidate vaccine, or Priorix (n=6), of whom 36 participants (86%; n=9, n=12, n=10, n=5, respectively) were included in the per-protocol population. The candidate vaccine raised neutralising antibodies in all dose cohorts after one immunisation, with seroconversion rates of 44% (n=4) in the low-dose group, 92% (n=11) in the medium-dose group, and 90% (n=10) in the high-dose group. The immunogenicity of the candidate vaccine was not affected by pre-existing anti-measles immunity. The second vaccination resulted in a 100% seroconversion for all participants in the candidate vaccine groups. The candidate vaccine had an overall good safety profile, and the rate of adverse events increased with vaccine dose and volume. No vaccination-related serious adverse events were recorded. Interpretation The live recombinant measles-virus-based chikungunya vaccine had good immunogenicity, even in the presence of anti-vector immunity, was safe, and had a generally acceptable tolerability profile. This vaccine is the first promising measles-virus-based candidate vaccine for use in human beings. C1 [Schwameis, Michael; Firbas, Christa; Jilma, Bernd] Med Univ Vienna, Dept Clin Pharmacol, A-1090 Vienna, Austria. [Ramsauer, Katrin; Muellner, Matthias; Tauber, Erich] Themis Biosci GmbH, Vienna, Austria. [Tangy, Frederic] Inst Pasteur, Viral Genom & Vaccinat Unit, Paris, France. [Tangy, Frederic] CNRS, UMR 3569, F-75700 Paris, France. [Despres, Philippe] Inst Pasteur, Dept Infect & Epidemiol, Mayotte, Reunion. [Despres, Philippe] UMR U1187 PIMIT I2T, Paris, France. [Putnak, Robert J.; Thomas, Stephen J.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD USA. RP Jilma, B (reprint author), Med Univ Vienna, Dept Clin Pharmacol, A-1090 Vienna, Austria. EM bernd.jilma@meduniwien.ac.at FU Themis Bioscience GmBH FX Themis Bioscience GmBH. NR 43 TC 29 Z9 29 U1 1 U2 12 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1473-3099 EI 1474-4457 J9 LANCET INFECT DIS JI Lancet Infect. Dis. PD MAY PY 2015 VL 15 IS 5 BP 519 EP 527 DI 10.1016/S1473-3099(15)70043-5 PG 9 WC Infectious Diseases SC Infectious Diseases GA CG9WK UT WOS:000353670600037 PM 25739878 ER PT J AU Camacho, M Certal, V Abdullatif, J Zaghi, S Ruoff, CM Capasso, R Kushida, CA AF Camacho, Macario Certal, Victor Abdullatif, Jose Zaghi, Soroush Ruoff, Chad M. Capasso, Robson Kushida, Clete A. TI Myofunctional Therapy to Treat Obstructive Sleep Apnea: A Systematic Review and Meta-analysis SO SLEEP LA English DT Article DE exercise therapy/methods; myofunctional therapy/methods; obstructive sleep apnea; sleep apnea syndromes ID POSITIVE AIRWAY PRESSURE; DAYTIME SLEEPINESS; MUSCLE TONUS; EXERCISES AB Objective: To systematically review the literature for articles evaluating myofunctional therapy (MT) as treatment for obstructive sleep apnea (OSA) in children and adults and to perform a meta-analysis on the polysomnographic, snoring, and sleepiness data. Data Sources: Web of Science, Scopus, MEDLINE, and The Cochrane Library. Review Methods: The searches were performed through June 18, 2014. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement was followed. Results: Nine adult studies (120 patients) reported polysomnography, snoring, and/or sleepiness outcomes. The pre- and post-MT apnea-hypopnea indices (AHI) decreased from a mean +/- standard deviation (M +/- SD) of 24.5 +/- 14.3/h to 12.3 +/- 11.8/h, mean difference (MD) -14.26 [95% confidence interval (CI) -20.98, -7.54], P < 0.0001. Lowest oxygen saturations improved from 83.9 +/- 6.0% to 86.6 +/- 7.3%, MD 4.19 (95% CI 1.85, 6.54), P = 0.0005. Polysomnography snoring decreased from 14.05 +/- 4.89% to 3.87 +/- 4.12% of total sleep time, P < 0.001, and snoring decreased in all three studies reporting subjective outcomes. Epworth Sleepiness Scale decreased from 14.8 +/- 3.5 to 8.2 +/- 4.1. Two pediatric studies (25 patients) reported outcomes. In the first study of 14 children, the AHI decreased from 4.87 +/- 3.0/h to 1.84 +/- 3.2/h, P = 0.004. The second study evaluated children who were cured of OSA after adenotonsillectomy and palatal expansion, and found that 11 patients who continued MT remained cured (AHI 0.5 +/- 0.4/h), whereas 13 controls had recurrent OSA (AHI 5.3 +/- 1.5/h) after 4 y. Conclusion: Current literature demonstrates that myofunctional therapy decreases apnea-hypopnea index by approximately 50% in adults and 62% in children. Lowest oxygen saturations, snoring, and sleepiness outcomes improve in adults. Myofunctional therapy could serve as an adjunct to other obstructive sleep apnea treatments. C1 [Camacho, Macario; Ruoff, Chad M.; Kushida, Clete A.] Stanford Hosp & Clin, Dept Psychiat, Div Sleep Med, Redwood City, CA USA. [Certal, Victor] Hosp CUF Porto, Sleep Med Ctr, Dept Otorhinolaryngol, P-4100 Oporto, Portugal. [Certal, Victor] Univ Porto, CINTESIS, Ctr Res Hlth Technol & Informat Syst, P-4100 Oporto, Portugal. [Abdullatif, Jose] Hosp Bernardino Rivadavia, Dept Otorhinolaryngol, Buenos Aires, DF, Argentina. [Zaghi, Soroush] Univ Calif Los Angeles, Dept Head & Neck Surg, Los Angeles, CA USA. [Capasso, Robson] Stanford Univ, Med Ctr, Dept Otolaryngol Head & Neck Surg, Sleep Surg Div, Stanford, CA 94305 USA. RP Camacho, M (reprint author), US Army, Stanford Hosp & Clin, Dept Psychiat, Div Sleep Med, 2nd Floor,450 Broadway St, Redwood City, CA 94063 USA. EM drcamachoent@yahoo.com RI FMUP, CINTESIS/C-6631-2014; OI FMUP, CINTESIS/0000-0001-7248-2086; Certal, Victor/0000-0002-1904-9504; Camacho, Macario/0000-0001-9200-9085 FU Aerial BioPharma; Pacific Medico Co., Ltd.; Resmed; Apnex Medical; Impax Laboratories, Inc.; Cephalon FX This was not an industry supported study. Dr. Kushida has received research support from Aerial BioPharma, Pacific Medico Co., Ltd., Resmed, Apnex Medical, Impax Laboratories, Inc., and Cephalon; has consulted for Apnex, Seven Dreamers Laboratories, Noven Pharmaceuticals, UCB, Philips-Respironics, Zephyr; and has received royalties from Philips Respironics. The other authors have indicated no financial conflicts of interest. The work was performed at Stanford Hospital and Clinics, Stanford, CA. The views herein are the private views of the authors and do not reflect the official views of the Department of the Army or the Department of Defense. NR 39 TC 21 Z9 21 U1 0 U2 7 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 EI 1550-9109 J9 SLEEP JI Sleep PD MAY 1 PY 2015 VL 38 IS 5 BP 669 EP + DI 10.5665/sleep.4652 PG 8 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA CH2TD UT WOS:000353876600005 PM 25348130 ER PT J AU Wierzbicki, TA Lee, IC Gupta, AK AF Wierzbicki, Teresa A. Lee, Ivan C. Gupta, Ashwani K. TI Rh assisted catalytic oxidation of jet fuel surrogates in a meso-scale combustor SO APPLIED ENERGY LA English DT Article DE Catalytic combustion; JP-8 surrogate; Meso-scale combustion; Reaction kinetics; Hybrid combustion ID HEAT-RECIRCULATING COMBUSTORS; GAS SHIFT REACTION; LOW-TEMPERATURE; HIGHER HYDROCARBONS; METAL-CATALYSTS; N-DECANE; PERFORMANCE; JP-8; GENERATION; COMPONENTS AB Oxidation behavior of dodecane and two mixtures of dodecane and m-xylene (90/10 wt.% and 80/20 wt.%) over an Rh catalyst in a meso-scale heat recirculating combustor was examined to isolate the effect of aromatic content on performance. The fuel conversion, product selectivities, and reaction kinetics were calculated, and the global combustion behavior observed. The results showed that increasing the amount of m-xylene in the fuel increased the fuel conversion from 85% (pure dodecane) to 92% (90/10) and further to 98% (80/20). The presence of xylene also significantly increased CO2/H2O selectivity and decreased CO/H-2 selectivity. Global activation energy increased linearly with increase in xylene content, supporting that addition of aromatic species to fuel lowers the overall reactivity. The non-catalytic reaction was also simulated using Chemkin software to determine the effect of the Rh catalyst on the combustor performance and to analyze the difference in chemical mechanisms. The results revealed that the catalyst promotes total oxidation over partial oxidation, and lowers the global activation energy by up to 70%. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Wierzbicki, Teresa A.; Gupta, Ashwani K.] Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA. [Wierzbicki, Teresa A.; Lee, Ivan C.] US Army, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. RP Gupta, AK (reprint author), Univ Maryland, Dept Mech Engn, 2181 Martin Hall,Campus Dr, College Pk, MD 20742 USA. EM twierz@umd.edu; ivan.c.lee2.civ@mail.mil; akgupta@umd.edu FU U.S. Army Research Laboratory; Reaction Design on the Chemkin FX Research support provided to Teresa Wierzbicki by the U.S. Army Research Laboratory is gratefully acknowledged. Thanks are also due to Dr. Vivek Shirsat for his help and support in various stages of this research and in the design and development of heat recirculating micro-combustors. The support provided by Reaction Design on the Chemkin code is gratefully acknowledged. NR 43 TC 7 Z9 7 U1 1 U2 15 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0306-2619 EI 1872-9118 J9 APPL ENERG JI Appl. Energy PD MAY 1 PY 2015 VL 145 BP 1 EP 7 DI 10.1016/j.apenergy.2015.01.097 PG 7 WC Energy & Fuels; Engineering, Chemical SC Energy & Fuels; Engineering GA CG0ZF UT WOS:000353002100001 ER PT J AU Belden, JB Lotufo, GR Biedenbach, JM Sieve, KK Rosen, G AF Belden, Jason B. Lotufo, Guilherme R. Biedenbach, James M. Sieve, Kristal K. Rosen, Gunther TI APPLICATION OF POCIS FOR EXPOSURE ASSESSMENT OF MUNITIONS CONSTITUENTS DURING CONSTANT AND FLUCTUATING EXPOSURE SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE TNT; RDX; Passive sampling; Fluctuating concentrations; POCIS ID CHEMICAL INTEGRATIVE SAMPLER; POLAR ORGANIC-COMPOUNDS; SOLID-PHASE EXTRACTION; AQUATIC ENVIRONMENTS; PASSIVE SAMPLER; WATER; CONTAMINANTS; PHARMACEUTICALS; CHROMATOGRAPHY; PERFORMANCE AB The present study examined the potential use of polar organic chemical integrative samplers (POCIS) for exposure assessment of munitions constituents, including 2,4,6-trinitrotoluene (TNT) and hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), and their breakdown products (aminodinitrotoluenes [ADNTs], diaminonitrotoluenes [DANTs], and hexahydro-1,3,5-trinitroso-1,3,5-triazine [TNX]). Loss of munitions constituents from the sorbent phase after uptake was observed for the pesticide POCIS configuration but not for the pharmaceutical configuration. Therefore, the latter was selected for further investigation. Under constant exposure conditions, TNT, ADNTs, DANT, RDX, and atrazine (a common environmental contaminant) accumulated at a linear rate for at least 14d, with sampling rates between 34mL/d and 215mL/d. When POCIS were exposed to fluctuating concentrations, analyte accumulation values were similar to values found during constant exposure, indicating that the sampler was indeed integrative. In contrast, caffeine (a common polar contaminant) and TNX did not accumulate at a linear rate and had a reduction in accumulation of greater than 50% on the POCIS during fluctuating exposures, demonstrating that POCIS did not sample those chemicals in an integrative manner. Moreover, in a flow-through microcosm containing the explosive formulation Composition B, TNT and RDX were readily measured using POCIS, despite relatively high turnover rates and thus reduced water concentrations. Mean water concentrations estimated from POCIS were +/- 37% of mean water concentrations measured by traditional grab sample collection. Thus, POCIS were found to have high utility for quantifying exposure to most munitions constituents evaluated (TNT, ADNTs, and RDX) and atrazine. Environ Toxicol Chem 2015;34:959-967. (c) 2014 SETAC C1 [Belden, Jason B.; Sieve, Kristal K.] Oklahoma State Univ, Dept Integrat Biol, Stillwater, OK 74078 USA. [Lotufo, Guilherme R.; Biedenbach, James M.] US Army Engineer Res & Dev Ctr, Vicksburg, MS USA. [Rosen, Gunther] Space & Naval Warfare SPAWAR Syst Ctr Pacific, San Diego, CA USA. RP Belden, JB (reprint author), Oklahoma State Univ, Dept Integrat Biol, Stillwater, OK 74078 USA. EM jbelden@okstate.edu FU US Navy's Environmental Sustainability Development to Integration (NESDI) program FX The US Navy's Environmental Sustainability Development to Integration (NESDI) program supported this research. Permission to publish this study was granted by the Chief of Naval Operations (N45) and the Chief of the US Army Corps of Engineers. The authors thank R. George for opinions on experimental design. NR 30 TC 6 Z9 6 U1 2 U2 20 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD MAY PY 2015 VL 34 IS 5 BP 959 EP 967 DI 10.1002/etc.2836 PG 9 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA CG6LQ UT WOS:000353412800005 PM 25475692 ER PT J AU Torres, DM Harrison, SA AF Torres, Dawn M. Harrison, Stephen A. TI Nonalcoholic Fatty Liver Disease: Fibrosis Portends a Worse Prognosis SO HEPATOLOGY LA English DT Editorial Material ID HEPATOCELLULAR-CARCINOMA; STEATOHEPATITIS C1 [Torres, Dawn M.] Walter Reed Natl Mil Med Ctr, Dept Med, Div Gastroenterol, Bethesda, MD USA. [Harrison, Stephen A.] San Antonio Mil Med Ctr, Dept Med, Div Gastroenterol, Ft Sam Houston, TX USA. RP Harrison, SA (reprint author), Brooke Army Med Ctr, Dept Med, Div Gastroenterol & Hepatol, Ft Sam Houston, TX 78234 USA. EM Stephen.a.harrison.mil@mail.mil NR 11 TC 5 Z9 6 U1 0 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0270-9139 EI 1527-3350 J9 HEPATOLOGY JI Hepatology PD MAY PY 2015 VL 61 IS 5 BP 1462 EP 1464 DI 10.1002/hep.27680 PG 3 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA CG4DR UT WOS:000353233500004 PM 25564771 ER PT J AU del Junco, DJ Bulger, EM Fox, EE Holcomb, JB Brasel, KJ Hoyt, DB Grady, JJ Duran, S Klotz, P Dubick, MA Wade, CE AF del Junco, Deborah J. Bulger, Eileen M. Fox, Erin E. Holcomb, John B. Brasel, Karen J. Hoyt, David B. Grady, James J. Duran, Sarah Klotz, Patricia Dubick, Michael A. Wade, Charles E. CA ROC Investigators TI Collider bias in trauma comparative effectiveness research: The stratification blues for systematic reviews SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED LA English DT Article DE Massive transfusion; Trauma; Randomised clinical trial; Survival; Resuscitation; Bias; Subgroup; Observational; Comparative effectiveness research ID 7.5-PERCENT SODIUM-CHLORIDE; BLOOD-CELL RATIOS; MASSIVE TRANSFUSION; HYPERTONIC RESUSCITATION; 6-PERCENT DEXTRAN-70; FLUID RESUSCITATION; MULTICENTER TRIAL; SURVIVOR BIAS; SALINE; HYPOTENSION AB Background: Collider bias, or stratifying data by a covariate consequence rather than cause (confounder) of treatment and outcome, plagues randomised and observational trauma research. Of the seven trials of prehospital hypertonic saline in dextran (HSD) that have been evaluated in systematic reviews, none found an overall between-group difference in survival, but four reported significant subgroup effects. We hypothesised that an avoidable type of collider bias often introduced inadvertently into trauma comparative effectiveness research could explain the incongruous findings. Methods: The two most recent HSD trials, a single-site pilot and a multi-site pivotal study, provided data for a secondary analysis to more closely examine the potential for collider bias. The two trials had followed the a priori statistical analysis plan to subgroup patients by a post-randomisation covariate and well-established surrogate for bleeding severity, massive transfusion (MT), >= 10 unit of red blood cells within 24 h of admission. Despite favourable HSD effects in the MT subgroup, opposite effects in the non-transfused subgroup halted the pivotal trial early. In addition to analyzing the data from the two trials, we constructed causal diagrams and performed a meta-analysis of the results from all seven trials to assess the extent to which collider bias could explain null overall effects with subgroup heterogeneity. Results: As in previous trials, HSD induced significantly greater increases in systolic blood pressure (SBP) from prehospital to admission than control crystalloid (p = 0.003). Proportionately more HSD than control decedents accrued in the non-transfused subgroup, but with paradoxically longer survival. Despite different study populations and a span of over 20 years across the seven trials, the reported mortality effects were consistently null, summary RR = 0.99 (p = 0.864, homogeneity p = 0.709). Conclusions: HSD delayed blood transfusion by modifying standard triggers like SBP with no detectable effect on survival. The reported heterogeneous HSD effects in subgroups can be explained by collider bias that trauma researchers can avoid by improved covariate selection and data capture strategies. (C) 2015 Elsevier Ltd. All rights reserved. C1 [del Junco, Deborah J.; Fox, Erin E.; Holcomb, John B.; Duran, Sarah; Wade, Charles E.] Univ Texas Hlth Sci Ctr Houston, Dept Surg, Houston, TX 77030 USA. [Bulger, Eileen M.; Klotz, Patricia] Univ Washington, Dept Surg, Seattle, WA 98195 USA. [Brasel, Karen J.] Oregon Hlth & Sci Univ, Dept Surg, Portland, OR 97201 USA. [Hoyt, David B.] Amer Coll Surg, Chicago, IL USA. [Grady, James J.] Univ Connecticut, Ctr Hlth, Inst Clin & Translat Sci, Farmington, CT USA. [Dubick, Michael A.] US Army, Inst Surg Res, San Antonio, TX USA. RP del Junco, DJ (reprint author), Univ Texas Hlth Sci Ctr Houston, Dept Surg, Houston, TX 77030 USA. EM deborah.j.deljunco@uth.tmc.edu FU US Army Medical Research and Materiel Command [W81XWH-08-C-0712]; University of Washington Data Coordinating Center from the National Heart, Lung and Blood Institute [5U01 HL077863]; National Institute of Neurological Disorders and Stroke; US Army Medical Research and Materiel Command; Canadian Institutes of Health Research (CIHR)-Institute of Circulatory and Respiratory Health; Heart, Stroke Foundation of Canada; American Heart Association; Defence Research and Development Canada FX This work was supported by subcontract W81XWH-08-C-0712 from the US Army Medical Research and Materiel Command. The Resuscitation Outcomes Consortium (ROC) is supported by a series of cooperative agreements at 10 regional clinical centres and one Data Coordinating Center (5U01 HL077863-University of Washington Data Coordinating Center) from the National Heart, Lung and Blood Institute in partnership with the National Institute of Neurological Disorders and Stroke, US Army Medical Research and Materiel Command, The Canadian Institutes of Health Research (CIHR)-Institute of Circulatory and Respiratory Health, Defence Research and Development Canada, the Heart, Stroke Foundation of Canada and the American Heart Association. The content is solely the responsibility of the authors and does not represent the official views, policy or position of the U.S. Department of Defense, the National Heart, Lung and Blood Institute or the National Institutes of Health. NR 49 TC 6 Z9 6 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0020-1383 EI 1879-0267 J9 INJURY JI Injury-Int. J. Care Inj. PD MAY PY 2015 VL 46 IS 5 BP 775 EP 780 DI 10.1016/j.injury.2015.01.043 PG 6 WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery GA CG2ZJ UT WOS:000353144900002 PM 25766096 ER PT J AU Jelis, E Clemente, M Kerwien, S Ravindra, NM Hespos, MR AF Jelis, Elias Clemente, Matthew Kerwien, Stacey Ravindra, Nuggehalli M. Hespos, Michael R. TI Metallurgical and Mechanical Evaluation of 4340 Steel Produced by Direct Metal Laser Sintering (vol 67, pg 582, 2015) SO JOM LA English DT Correction C1 [Jelis, Elias; Clemente, Matthew; Kerwien, Stacey; Hespos, Michael R.] US Army ARDEC, Picatinny Arsenal, NJ 07806 USA. [Jelis, Elias; Ravindra, Nuggehalli M.] New Jersey Inst Technol, Interdisciplinary Program Mat Sci & Engn, Newark, NJ 07102 USA. RP Jelis, E (reprint author), US Army ARDEC, Picatinny Arsenal, NJ 07806 USA. EM nmravindra@gmail.com NR 1 TC 0 Z9 0 U1 3 U2 12 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1047-4838 EI 1543-1851 J9 JOM-US JI JOM PD MAY PY 2015 VL 67 IS 5 BP 1214 EP 1215 DI 10.1007/s11837-015-1368-x PG 2 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering; Mineralogy; Mining & Mineral Processing SC Materials Science; Metallurgy & Metallurgical Engineering; Mineralogy; Mining & Mineral Processing GA CG4BD UT WOS:000353224600040 ER PT J AU Shiozawa, BJ AF Shiozawa, Brian J. TI It's About Time for Autism Reform Legislation in Utah SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS LA English DT Article DE Autism; Insurance; Legislation; Reform; Applied behavioral analysis AB On 3 April 2014, Governor Gary Herbert signed into law a health insurance reform bill that requires private insurers to cover autism therapy. Specifically, SB57 requires state-regulated health plans to cover applied behavior analysis (ABA) therapy. While early diagnosis and intervention can reduce the long-term cost of autism, families are finding themselves bankrupt in order to pay for ABA therapy. Currently, 37 states, and the District of Columbia have enacted insurance reform laws. Ensuring that children with autism receive proper therapy is a serious public health issue. Utah was right to pass reform legislation because it properly benefits and safeguards the interests of affected children in promoting their well-being and participation in society. C1 Mendoza Soldier Family Care Clin, William Beaumont Army Med Ctr, Ft Bliss, TX 79916 USA. RP Shiozawa, BJ (reprint author), Mendoza Soldier Family Care Clin, William Beaumont Army Med Ctr, 11335 SSG Sims St, Ft Bliss, TX 79916 USA. EM brian.shiozawa@gmail.com NR 8 TC 0 Z9 0 U1 1 U2 2 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0162-3257 EI 1573-3432 J9 J AUTISM DEV DISORD JI J. Autism Dev. Disord. PD MAY PY 2015 VL 45 IS 5 BP 1495 EP 1496 DI 10.1007/s10803-014-2302-8 PG 2 WC Psychology, Developmental SC Psychology GA CG6JS UT WOS:000353407200033 PM 25395093 ER PT J AU Stromdahl, EY Nadolny, RM Gibbons, JA Auckland, LD Vince, MA Elkins, CE Murphy, MP Hickling, GJ Eshoo, MW Carolan, HE Crowder, CD Pilgard, MA Hamer, SA AF Stromdahl, Ellen Y. Nadolny, Robyn M. Gibbons, Jennifer A. Auckland, Lisa D. Vince, Mary A. Elkins, Chad E. Murphy, Michael P. Hickling, Graham J. Eshoo, Mark W. Carolan, Heather E. Crowder, Chris D. Pilgard, Mark A. Hamer, Sarah A. TI Borrelia burgdorferi Not Confirmed in Human-Biting Amblyomma americanum Ticks from the Southeastern United States SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID LYME-DISEASE SPIROCHETE; IXODES-SCAPULARIS; DERMACENTOR-VARIABILIS; ERYTHEMA MIGRANS; IXODIDAE; ACARI; INFECTION; TRANSMISSION; PREVALENCE; STRAIN AB The predominant human-biting tick throughout the southeastern United States is Amblyomma americanum. Its ability to transmit pathogens causing Lyme disease-like illnesses is a subject of ongoing controversy. Results of previous testing by the Department of Defense Human Tick Test Kit Program and other laboratories indicated that it is highly unlikely that A. americanum transmits any pathogen that causes Lyme disease. In contrast, a recent publication by Clark and colleagues (K. L. Clark, B. Leydet, and S. Hartman, Int. J. Med. Sci. 10: 915-931, 2013) reported detection of Lyme group Borrelia in A. americanum using a nested-flagellin-gene PCR. We evaluated this assay by using it and other assays to test 1,097 A. americanum ticks collected from humans. Using the Clark assay, in most samples we observed nonspecific amplification and nonrepeatability of results on subsequent testing of samples. Lack of reaction specificity and repeatability is consistent with mispriming, likely due to high primer concentrations and low annealing temperatures in this protocol. In six suspect-positive samples, Borrelia lonestari was identified by sequencing of an independent gene region; this is not a Lyme group spirochete and is not considered zoonotic. B. burgdorferi was weakly amplified from one pool using some assays, but not others, and attempts to sequence the amplicon of this pool failed, as did attempts to amplify and sequence B. burgdorferi from the five individual samples comprising this pool. Therefore, B. burgdorferi was not confirmed in any sample. Our results do not support the hypothesis that A. americanum ticks are a vector for Lyme group Borrelia infections. C1 [Stromdahl, Ellen Y.; Nadolny, Robyn M.; Vince, Mary A.; Elkins, Chad E.; Murphy, Michael P.] US Army Publ Hlth Command, Aberdeen Proving Ground, MD 21010 USA. [Nadolny, Robyn M.] Old Dominion Univ, Dept Biol Sci, Norfolk, VA 23529 USA. [Gibbons, Jennifer A.] US Army Edgewood Chem & Biol Ctr, Aberdeen Proving Ground, MD USA. [Gibbons, Jennifer A.] Sci & Technol Corp, Hampton, VA USA. [Auckland, Lisa D.; Hamer, Sarah A.] Texas A&M Univ, Dept Vet Integrat Biosci, College Stn, TX USA. [Hickling, Graham J.] Univ Tennessee, Inst Agr, Ctr Wildlife Hlth, Knoxville, TN 37901 USA. [Eshoo, Mark W.; Carolan, Heather E.; Crowder, Chris D.] Ibis Biosci, Carlsbad, CA USA. [Pilgard, Mark A.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO USA. RP Stromdahl, EY (reprint author), US Army Publ Hlth Command, Aberdeen Proving Ground, MD 21010 USA. EM Ellen.y.stromdahl.civ@mail.mil NR 38 TC 6 Z9 6 U1 1 U2 7 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 EI 1098-660X J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD MAY PY 2015 VL 53 IS 5 BP 1697 EP 1704 DI 10.1128/JCM.03454-14 PG 8 WC Microbiology SC Microbiology GA CG1MK UT WOS:000353036500032 PM 25788545 ER PT J AU Beehr, TA Ragsdale, JM Kochert, JF AF Beehr, Terry A. Ragsdale, Jennifer M. Kochert, Jonathan F. TI Effects of initial resources on the development of strains during a stressful training situation: Some counterintuitive results SO JOURNAL OF ORGANIZATIONAL BEHAVIOR LA English DT Article DE occupational stress; strains; resources; training ID SOCIAL SUPPORT; JOB DEMANDS; EXPLANATORY MECHANISM; BURNOUT; DEPRESSION; MODEL; PERSONALITY; SYMPTOMS; DISORDER; IMPACT AB Resource theories of occupational stress argue that employees' personal and environmental resources protect them from too much distress or strain during stressful work experiences. We examined four resources (emotional stability, previous experience, low drain on pre-existing resources, and workgroup quality) available to soldiers at the beginning of a stressful 3-month training experience as predictors of the trajectories of their strains over that period of time. Based on conservation of resources theory and the job demands-resources model, we predicted that the trends of strains would be more favorable (would increase more slowly or decline more quickly) if participants started the training with greater resources. The resources, primarily emotional stability and lack of pre-existing resource drain, tended to be negatively related to strains, consistent with the idea that they can reduce strains. Significant interactions predicting trends were found predicting two of the three strains (post-traumatic stress symptoms and depression, but not reports of physical health). Contrary to expectations, however, the three resources that significantly predicted trends over time (emotional stability, previous experience, and low pre-existing resource drain) were associated with worsening rather than improving strains. Copyright (c) 2014 John Wiley & Sons, Ltd. C1 [Beehr, Terry A.] Cent Michigan Univ, Dept Psychol, Mt Pleasant, MI 48859 USA. [Ragsdale, Jennifer M.] Univ Tulsa, Dept Psychol, Tulsa, OK 74104 USA. [Kochert, Jonathan F.] Army Res Inst, Leavenworth, KS USA. RP Beehr, TA (reprint author), Cent Michigan Univ, Dept Psychol, Mt Pleasant, MI 48859 USA. EM beehr1ta@cmich.edu NR 76 TC 0 Z9 0 U1 5 U2 23 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0894-3796 EI 1099-1379 J9 J ORGAN BEHAV JI J. Organ. Behav. PD MAY PY 2015 VL 36 IS 4 BP 467 EP 490 DI 10.1002/job.1974 PG 24 WC Business; Psychology, Applied; Management SC Business & Economics; Psychology GA CG6JM UT WOS:000353406500001 ER PT J AU Mondloch, JE Katz, MJ Isley, WC Ghosh, P Liao, PL Bury, W Wagner, G Hall, MG DeCoste, JB Peterson, GW Snurr, RQ Cramer, CJ Hupp, JT Farha, OK AF Mondloch, Joseph E. Katz, Michael J. Isley, William C., III Ghosh, Pritha Liao, Peilin Bury, Wojciech Wagner, GeorgeW. Hall, Morgan G. DeCoste, Jared B. Peterson, Gregory W. Snurr, Randall Q. Cramer, Christopher J. Hupp, Joseph T. Farha, Omar K. TI Destruction of chemical warfare agents using metal-organic frameworks SO NATURE MATERIALS LA English DT Article ID DETOXIFICATION AB Chemical warfare agents containing phosphonate ester bonds are among the most toxic chemicals known to mankind(1). Recent global military events, such as the conflict and disarmament in Syria(2), have brought into focus the need to find effective strategies for the rapid destruction of these banned chemicals. Solutions are needed for immediate personal protection (for example, the filtration and catalytic destruction of airborne versions of agents), bulk destruction of chemical weapon stockpiles, protection (via coating) of clothing, equipment and buildings, and containment of agent spills(3). Solid heterogeneous materials such as modified activated carbon or metal oxides exhibit many desirable characteristics for the destruction of chemical warfare agents(4-6). However, low sorptive capacities, low effective active site loadings, deactivation of the active site, slow degradation kinetics, and/or a lack of tailorability offer significant room for improvement in these materials. Here, we report a carefully chosen metal-organic framework (MOF) material featuring high porosity and exceptional chemical stability that is extraordinarily effective for the degradation of nerve agents and their simulants. Experimental and computational evidence points to Lewis-acidic Zr-IV ions as the active sites and to their superb accessibility as a defining element of their efficacy. C1 [Mondloch, Joseph E.; Katz, Michael J.; Bury, Wojciech; Hupp, Joseph T.; Farha, Omar K.] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA. [Isley, William C., III; Cramer, Christopher J.] Univ Minnesota, Supercomp Inst, Dept Chem, Minneapolis, MN 55455 USA. [Isley, William C., III; Cramer, Christopher J.] Univ Minnesota, Chem Theory Ctr, Minneapolis, MN 55455 USA. [Ghosh, Pritha; Liao, Peilin; Snurr, Randall Q.] Northwestern Univ, Dept Chem & Biol Engn, Evanston, IL 60208 USA. [Wagner, GeorgeW.; Hall, Morgan G.; Peterson, Gregory W.] US Army Res Dev & Engn Command, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. [DeCoste, Jared B.] Leidos Inc, Aberdeen Proving Ground, MD 21010 USA. [Farha, Omar K.] King Abdulaziz Univ, Dept Chem, Fac Sci, Jeddah 21589, Saudi Arabia. RP Hupp, JT (reprint author), Northwestern Univ, Dept Chem, 2145 Sheridan Rd, Evanston, IL 60208 USA. EM j-hupp@northwestern.edu; o-farha@northwestern.edu RI Snurr, Randall/B-6699-2009; Cramer, Christopher/B-6179-2011; Liao, Peilin/O-2984-2013; OI Cramer, Christopher/0000-0001-5048-1859; Liao, Peilin/0000-0002-3516-9514; Isley, William/0000-0002-1887-1221; Katz, Michael/0000-0002-7744-3956 FU DTRA [HDTRA-1-10-0023]; US DOE, Office of Basic Energy Sciences, Division of Chemical Sciences, Geosciences and Biosciences [DE-FG02-12ER16362]; National Energy Research Scientific Computing Center (NERSC); Joint Science and Technology Office for Chemical Biological Defense (JSTO-CBD) [BA13PHM210] FX O.K.F., R.Q.S. and J.T.H. gratefully acknowledge DTRA for financial support (grant HDTRA-1-10-0023). C.J.C. gratefully acknowledges funding from the US DOE, Office of Basic Energy Sciences, Division of Chemical Sciences, Geosciences and Biosciences (Award DE-FG02-12ER16362). R.Q.S. acknowledges the National Energy Research Scientific Computing Center (NERSC) for computational resources. J.B.D. and G.W.P. gratefully acknowledge Joint Science and Technology Office for Chemical Biological Defense (JSTO-CBD) for funding (Project Number BA13PHM210). NR 22 TC 112 Z9 112 U1 59 U2 348 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1476-1122 EI 1476-4660 J9 NAT MATER JI Nat. Mater. PD MAY PY 2015 VL 14 IS 5 BP 512 EP 516 DI 10.1038/NMAT4238 PG 5 WC Chemistry, Physical; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Materials Science; Physics GA CG5BQ UT WOS:000353305700018 PM 25774952 ER PT J AU Liu, JB Khitrov, MY Gates, JD Odom, SR Havens, JM de Moya, MA Wilkins, K Wedel, SK Kittell, EO Reifman, J Reisner, AT AF Liu, Jianbo Khitrov, Maxim Y. Gates, Jonathan D. Odom, Stephen R. Havens, Joaquim M. de Moya, Marc A. Wilkins, Kevin Wedel, Suzanne K. Kittell, Erin O. Reifman, Jaques Reisner, Andrew T. TI AUTOMATED ANALYSIS OF VITAL SIGNS TO IDENTIFY PATIENTS WITH SUBSTANTIAL BLEEDING BEFORE HOSPITAL ARRIVAL: A FEASIBILITY STUDY SO SHOCK LA English DT Article DE Trauma; hemorrhage; massive transfusion; decision-support systems; prehospital emergency care ID TRAUMA PATIENTS; SHOCK INDEX; EMERGENCY-DEPARTMENT; MASSIVE TRANSFUSION; RESPIRATORY RATE; BLOOD-PRESSURE; RESUSCITATION; REQUIREMENT; IMPROVEMENT; ALGORITHMS AB Trauma outcomes are improved by protocols for substantial bleeding, typically activated after physician evaluation at a hospital. Previous analysis suggested that prehospital vital signs contained patterns indicating the presence or absence of substantial bleeding. In an observational study of adults (aged >= 18 years) transported to level I trauma centers by helicopter, we investigated the diagnostic performance of the Automated Processing of the Physiological Registry for Assessment of Injury Severity (APPRAISE) system, a computational platform for real-time analysis of vital signs, for identification of substantial bleeding in trauma patients with explicitly hemorrhagic injuries. We studied 209 subjects prospectively and 646 retrospectively. In our multivariate analysis, prospective performance was not significantly different from retrospective. The APPRAISE system was 76% sensitive for 24-h packed red blood cells of 9 or more units (95% confidence interval, 59%-89%) and significantly more sensitive (P < 0.05) than any prehospital Shock Index of 1.4 or higher; sensitivity, 59%; initial systolic blood pressure (SBP) less than 110 mmHg, 50%; and any prehospital SBP less than 90 mmHg, 50%. The APPRAISE specificity for 24-h packed red blood cells of 0 units was 87% (88% for any Shock Index >= 1.4, 88% for initial SBP <110 mmHg, and 90% for any prehospital SBP <90 mmHg). Median APPRAISE hemorrhage notification time was 20 min before arrival at the trauma center. In conclusion, APPRAISE identified bleeding before trauma center arrival. En route, this capability could allow medics to focus on direct patient care rather than the monitor and, via advance radio notification, could expedite hospital interventions for patients with substantial blood loss. C1 [Liu, Jianbo; Khitrov, Maxim Y.; Reifman, Jaques] US Army Med Res & Mat Command, Dept Def, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. [Gates, Jonathan D.; Havens, Joaquim M.] Brigham & Womens Hosp, Dept Surg, Div Trauma Burns & Surg Crit Care, Boston, MA 02115 USA. [Odom, Stephen R.] Beth Israel Deaconess Med Ctr, Dept Surg, Div Acute Care Surg Trauma & Surg Crit Care, Boston, MA 02215 USA. [de Moya, Marc A.] Massachusetts Gen Hosp, Dept Surg, Div Trauma Emergency Surg & Surg Crit Care, Boston, MA 02114 USA. [Wilkins, Kevin; Wedel, Suzanne K.] Boston MedFlight, Boston, MA USA. [Kittell, Erin O.; Reisner, Andrew T.] Massachusetts Gen Hosp, Dept Emergency Med, Boston, MA 02114 USA. RP Reifman, J (reprint author), US Army Med Res & Mat Command, US Dept Def, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr,ATTN MCMR TT, 504 Scott St, Ft Detrick, MD 21702 USA. EM jaques.reifman.civ@mail.mil FU US Department of Defense Medical Research and Development Program [D10_I_AR_J6_773]; Combat Casualty Care Research Area Directorate of the US Army Medical Research and Materiel Command, Fort Detrick, Maryland FX This work was supported by the US Department of Defense Medical Research and Development Program (grant no. D10_I_AR_J6_773) and by the Combat Casualty Care Research Area Directorate of the US Army Medical Research and Materiel Command, Fort Detrick, Maryland. The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U.S. Army or of the U.S. Department of Defense. This paper has been approved for public release with unlimited distribution. NR 37 TC 5 Z9 5 U1 1 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD MAY PY 2015 VL 43 IS 5 BP 429 EP 436 DI 10.1097/SHK.0000000000000328 PG 8 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA CG2ZT UT WOS:000353146200002 PM 25664983 ER PT J AU Sarkar, J Golden, PJ Kajiura, LN Murata, LAM Uyehara, CFT AF Sarkar, Joy Golden, Patrick J. Kajiura, Lauren N. Murata, Lee-Ann M. Uyehara, Catherine F. T. TI VASOPRESSIN DECREASES PULMONARY-TO-SYSTEMIC VASCULAR RESISTANCE RATIO IN A PORCINE MODEL OF SEVERE HEMORRHAGIC SHOCK SO SHOCK LA English DT Article DE Vasopressin; norepinephrine; phenylephrine; hemorrhage; resuscitation; pulmonary hypertension; PVR; SVR; vasoconstriction; oxygenation ID FLUID RESUSCITATION STRATEGIES; LIVER TRAUMA; SEPTIC SHOCK; ARGININE-VASOPRESSIN; MANAGEMENT; NOREPINEPHRINE; PRESSURE; SURVIVAL; SUPPORT; OPTIONS AB Vasopressors are gaining renewed interest as treatment adjuncts in hemorrhagic shock. The ideal vasoconstrictor will increase systemic blood pressure without increasing pulmonary vascular resistance (PVR), which hinders pulmonary perfusion and exacerbates hypoxemia. However, the selectivity of pressors for pulmonary versus systemic vasoconstriction during hemorrhage has not been characterized. The purpose of this study was to test the hypothesis that vasopressin (VP) has distinct effects on pulmonary versus systemic hemodynamics, unlike the catecholamine vasopressors norepinephrine (NE) and phenylephrine (PE). Anesthetized and ventilated pigs were assigned to resuscitation with saline only (n = 7) or saline with VP (n = 6), NE (n = 6), or PE (n = 6). Animals were hemorrhaged to a target volume of 30 mL/kg and a mean arterial pressure of 35 mmHg. One hour after the start of hemorrhage, animals were resuscitated with saline up to one shed blood volume, followed by either additional saline or a vasopressor. Hemodynamics and oxygenation were measured hourly for 4 h after the start of hemorrhage. Vasopressin increased systemic vascular resistance (SVR) while sparing the pulmonary vasculature, leading to a 45% decrease in the PVR/SVR ratio compared with treatment with PE. Conversely, NE induced pulmonary hypertension and led to an increased PVR/SVR ratio associated with decreased oxygen saturation. Phenylephrine and crystalloid had no significant effect on the PVR/SVR ratio. Sparing of pulmonary vasoconstriction occurs only with VP, not with administration of crystalloid or catecholamine pressors. The ability of VP to maintain blood oxygenation indicates that VP may prevent hypoxemia in the management of hemorrhagic shock. C1 [Sarkar, Joy; Golden, Patrick J.] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. [Kajiura, Lauren N.; Murata, Lee-Ann M.; Uyehara, Catherine F. T.] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. RP Uyehara, CFT (reprint author), Tripler Army Med Ctr, Dept Clin Invest, MCHK CI CDR TAMC, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM catherine.uyehara.tamc@gmail.com FU US Army Medical Research and Materiel Command FX This work was supported by the US Army Medical Research and Materiel Command. The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of the Army, Department of Defense, or the US Government. NR 35 TC 7 Z9 7 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD MAY PY 2015 VL 43 IS 5 BP 475 EP 482 DI 10.1097/SHK.0000000000000325 PG 8 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA CG2ZT UT WOS:000353146200009 PM 25565637 ER PT J AU Parida, BK Garrastazu, H Aden, JK Cap, AP McFaul, SJ AF Parida, Bijaya Kumar Garrastazu, Hiram Aden, James Keith Cap, Andrew Peter McFaul, Steve John TI Silica microspheres are superior to polystyrene for microvesicle analysis by flow cytometry SO THROMBOSIS RESEARCH LA English DT Article DE Microvesicles; Cell-derived microparticles; Silica microspheres; Polystyrene microspheres; Platelets ID MICROPARTICLE SIZE; BIOLOGICAL MICROPARTICLES; MEMBRANE-VESICLES; PERIPHERAL-BLOOD; PARTICLE-SIZE; CALIBRATION; BEADS; EXOSOMES AB Background: Cell-derived microvesicles (MVs) in biological fluids are studied for their potential role in pathological conditions. Flow cytometry is used to characterize MVs. Polystyrene microspheres are often used in flow cytometry to distinguish MV from cells by setting a 1-mu mMV gate in a side-scatter (SSC) vs. forward-scatter (FSC) dot plot. Polystyrene microspheres, however, exhibit higher FSC and SSC than MVs of equal size. Consequently, some platelets are included within the MV gate, which incorrectly increases the reported percentage of platelet-derived MVs. Silica microspheres exhibit FSC that is closer to that of cellular vesicles and, therefore, should permit more accurate discrimination of MV from platelets. Objective: Compare silica with polystyrene microspheres to calibrate flow cytometers for definition of MV population and estimation of MV sizes. Methods: Silica and polystyrene microspheres of various sizes were used in flow cytometry assays to define MV populations and determine platelet and MV sizes in human plasma samples. Sizes determined by flow cytometry were compared to sizes determined by resistive pulse sensing (RPS) method. Results/Conclusion: Use of 1.0-mu m polystyrene microspheres to define the upper MV gate produced a median platelet contamination of 16.53% (8.24, 20.98) of the MV population; whereas, use of 1.0-mu m silica microspheres excluded platelet events completely. Calibration with silica microspheres resulted in significantly better estimation of MV diameter than calibration with polystyrene microspheres. We conclude that silica microspheres are superior to polystyrene microspheres as standards to define MV populations without platelet contamination and to determine MV sizes by flow cytometry for a given cytometer. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Parida, Bijaya Kumar; Garrastazu, Hiram; Aden, James Keith; Cap, Andrew Peter; McFaul, Steve John] US Army, Inst Surg Res, Coagulat & Blood Res Program, Jbsa Ft Sam Houston, TX 78234 USA. RP Parida, BK (reprint author), US Army, Inst Surg Res, Coagulat & Blood Res Program, 3650 Chambers Pass,Bldg 3610, Jbsa Ft Sam Houston, TX 78234 USA. EM bijaya.k.parida.vol@mail.mil OI Parida, Bijaya/0000-0002-0338-2011 FU U.S. Army Medical Research and Materiel Command; National Research Council fellowship FX We thank Ms. Otilia Sanchez for proofreading the manuscript. This study was funded by the U.S. Army Medical Research and Materiel Command. B. K. Parida is the recipient of a National Research Council fellowship. NR 28 TC 4 Z9 4 U1 5 U2 18 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0049-3848 J9 THROMB RES JI Thromb. Res. PD MAY PY 2015 VL 135 IS 5 BP 1000 EP 1006 DI 10.1016/j.thromres.2015.02.011 PG 7 WC Hematology; Peripheral Vascular Disease SC Hematology; Cardiovascular System & Cardiology GA CG7NP UT WOS:000353490800035 PM 25726425 ER PT J AU Montgomery, VA Ahmed, SA Olson, MA Mizanur, RM Stafford, RG Roxas-Duncan, VI Smith, LA AF Montgomery, Vicki A. Ahmed, S. Ashraf Olson, Mark A. Mizanur, Rahman M. Stafford, Robert G. Roxas-Duncan, Virginia I. Smith, Leonard A. TI Ex vivo inhibition of Clostridium botulinum neurotoxin types B, C, E, and F by small molecular weight inhibitors SO TOXICON LA English DT Article DE C. botulinum neurotoxins; Inhibitors ID PROTEOLYTIC ACTIVITY; INFANT BOTULISM; IMMUNE GLOBULIN; SEROTYPE-E; FUTURE; DOMAIN; TOXIN AB Two small molecular weight inhibitors, compounds CB7969312 and CB7967495, that displayed inhibition of botulinum neurotoxin serotype A in a previous study, were evaluated for inhibition of botulinum neurotoxin serotypes B, C, E, and F. The small molecular weight inhibitors were assessed by molecular modeling, UPLC-based peptide cleavage assay; and an ex vivo assay, the mouse phrenic nerve - hemidiaphragm assay (MPNHDA). While both compounds were inhibitors of botulinum neurotoxin (BoNT) serotypes B, C, and F in the MPNHDA, compound CB7969312 was effective at lower molar concentrations than compound CB7967495. However, compound CB7967495 was significantly more effective at preventing BoNTE intoxication than compound CB7969312. In the UPLC-based peptide cleavage assay, CB7969312 was also more effective against LcC. Both compounds inhibited BoNTE, but not BoNTF, LcE, or LcF in the UPLC-based peptide cleavage assay. Molecular modeling studies predicted that both compounds would be effective inhibitors of BoNTs B, C, E, and F. But CB7967495 was predicted to be a more effective inhibitor of the four serotypes (B, C, E, and F) than CB7969312. This is the first report of a small molecular weight compound that inhibits serotypes B, C, E, and F in the ex vivo assay. Published by Elsevier Ltd. C1 [Montgomery, Vicki A.; Ahmed, S. Ashraf; Olson, Mark A.; Stafford, Robert G.] US Army, Med Res Inst Infect Dis, Div MTS, Ft Detrick, MD 21702 USA. [Mizanur, Rahman M.; Roxas-Duncan, Virginia I.] US Army, Med Res Inst Infect Dis, Biosurety Div, Ft Detrick, MD 21702 USA. [Smith, Leonard A.] US Army, Med Res & Mat Command, Med Countermeasures Technol, Frederick, MD USA. RP Montgomery, VA (reprint author), US Army, Med Res Inst Infect Dis, Div MTS, 1425 Porter St, Ft Detrick, MD 21702 USA. EM vicki.a.montgomery.civ@mail.mil; syed.a.ahmed.civ@mail.mil; mark.a.olson1.civ@mail.mil; mdmizanur.rahman.civ@mail.mil; robert.g.stafford2.civ@mail.mil; virginia.i.duncan.civ@mail.mil; leonard.a.smith1.civ@mail.mil FU Defense Threat Reduction Agency/JSTO-CBD under USAMRIID project [1321195] FX The research was funded by Defense Threat Reduction Agency/JSTO-CBD under USAMRIID project number 1321195. NR 35 TC 2 Z9 2 U1 0 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0041-0101 J9 TOXICON JI Toxicon PD MAY PY 2015 VL 98 BP 12 EP 19 DI 10.1016/j.toxicon.2015.02.012 PG 8 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA CG6PV UT WOS:000353425100003 PM 25707753 ER PT J AU Opsenica, IM Verbic, TZ Tot, M Sciotti, RJ Pybus, BS Djurkovic-Djakovic, O Slavic, K Solaja, BA AF Opsenica, Igor M. Verbic, Tatjana Z. Tot, Miklos Sciotti, Richard J. Pybus, Brandon S. Djurkovic-Djakovic, Olgica Slavic, Ksenija Solaja, Bogdan A. TI Investigation into novel thiophene- and furan-based 4-amino-7-chloroquinolines afforded antimalarials that cure mice SO BIOORGANIC & MEDICINAL CHEMISTRY LA English DT Article DE Malaria; Thiophene; Furan; Aminoquinoline inhibitors; P. berghei; Chemotherapy; Cytotoxicity; beta-Hematin polymerization inhibitors ID IN-VITRO; ANTIPLASMODIAL ACTIVITY; INHIBITORY-ACTIVITY; MALARIA; DRUGS; 4-AMINOQUINOLINES; FALCIPARUM; VIVO; CHLOROQUINE; DERIVATIVES AB We herein report the design and synthesis of a novel series of thiophene-and furan-based aminoquinoline derivatives which were found to be potent antimalarials and inhibitors of b-hematin polymerization. Tested compounds were 3-71 times more potent in vitro than CQ against chloroquine-resistant (CQR) W2 strain with benzonitrile 30 being as active as mefloquine (MFQ), and almost all synthesized aminoquinolines (22/27) were more potent than MFQ against multidrug-resistant (MDR) strain C235. In vivo experiments revealed that compound 28 showed clearance with recrudescence at 40 mg/kg/day, while 5/5 mice survived in Thompson test at 160 mg/kg/day. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Opsenica, Igor M.; Verbic, Tatjana Z.; Tot, Miklos; Solaja, Bogdan A.] Univ Belgrade, Fac Chem, Belgrade 11158, Serbia. [Sciotti, Richard J.; Pybus, Brandon S.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. [Djurkovic-Djakovic, Olgica; Slavic, Ksenija] Univ Belgrade, Inst Med Res, Belgrade 11129, Serbia. RP Solaja, BA (reprint author), Univ Belgrade, Fac Chem, Studentski Trg 16,POB 51, Belgrade 11158, Serbia. EM bsolaja@chem.bg.ac.rs RI Opsenica, Igor/P-5308-2016; Verbic, Tatjana/Q-3529-2016; OI Opsenica, Igor/0000-0003-4942-4042; Verbic, Tatjana/0000-0002-6348-1644; Solaja, Bogdan/0000-0002-9975-2725 FU Ministry of Science and Technological Development of Serbia [172008, 41019]; Serbian Academy of Sciences and Arts FX This research was financially supported by the Ministry of Science and Technological Development of Serbia (Grants no. 172008 and 41019) and the Serbian Academy of Sciences and Arts. The contents of this manuscript have been reviewed by the Walter Reed Army Institute of Research. There is no objection to its presentation or publication. NR 30 TC 5 Z9 5 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0968-0896 EI 1464-3391 J9 BIOORGAN MED CHEM JI Bioorg. Med. Chem. PD MAY 1 PY 2015 VL 23 IS 9 BP 2176 EP 2186 DI 10.1016/j.bmc.2015.02.061 PG 11 WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Chemistry, Organic SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry GA CF6WZ UT WOS:000352698700027 PM 25801154 ER PT J AU Ananworanich, J McSteen, B Robb, ML AF Ananworanich, Jintanat McSteen, Brian Robb, Merlin L. TI Broadly neutralizing antibody and the HIV reservoir in acute HIV infection: a strategy toward HIV remission? SO CURRENT OPINION IN HIV AND AIDS LA English DT Review DE acute HIV infection; antibody; broadly neutralizing antibody; early antiretroviral therapy; HIV DNA; HIV reservoir; replication-competent virus ID CD4(+) T-CELLS; HUMANIZED MICE; ANTIRETROVIRAL THERAPY; LATENT RESERVOIR; VIRAL RESERVOIR; RHESUS-MONKEYS; VIREMIA; REPLICATION; ERADICATION; DRIVEN AB Purpose of review Infection of long-lived CD4(+) T cells is a major obstacle to HIV remission, and antiretroviral therapy (ART) instituted during acute HIV infection restricts HIV reservoir establishment. Broadly neutralizing antibodies (bNAbs) may be employed in conjunction with early ART as strategies toward HIV remission. Recent findings Proof-of-concept studies in vitro and in animal models demonstrated bNAbs' ability to block viral entry into cells, suppress viremia and reduce cell-associated viral DNA. Combination bNAbs were more effective than single bNAb in suppressing viremia. When bNAb was used with ART with or without combination latency reversing agents, it prevented viral rebound after ART interruption in at least half of the animals. In one study, macaques with low baseline viral load achieved viral remission even after the blood bNAb titer was no longer detected. Summary The acute HIV infection period represents a unique opportunity to explore the use of bNAbs with ART to limit the reservoir seeding that may enhance the chance of HIV remission. This article discusses the effects of early ART and bNAbs on HIV reservoirs and proposes research strategies in acute HIV infection aiming at HIV reservoir reduction and HIV remission. C1 [Ananworanich, Jintanat; McSteen, Brian; Robb, Merlin L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Ananworanich, Jintanat; McSteen, Brian; Robb, Merlin L.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. RP Ananworanich, J (reprint author), US Mil HIV Res Program, 6720A Rockledge Dr,Suite 400, Bethesda, MD 20817 USA. EM Jananworanich@hivresearch.org FU National Institute of Allergy and Infectious Diseases [R01HD080435-01] FX The given work was supported in part by grants to J.A. from the National Institute of Allergy and Infectious Diseases (R01HD080435-01). NR 37 TC 3 Z9 3 U1 1 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1746-630X EI 1746-6318 J9 CURR OPIN HIV AIDS JI Curr. Opin. HIV AIDS PD MAY PY 2015 VL 10 IS 3 BP 198 EP 206 DI 10.1097/COH.0000000000000144 PG 9 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA CF8GG UT WOS:000352793600010 PM 25700203 ER PT J AU Dar, RA Naikoo, GA Kalambate, PK Giri, L Khan, F Karna, SP Srivastava, AK AF Dar, Riyaz A. Naikoo, Gowhar A. Kalambate, Pramod K. Giri, Lily Khan, Farid Karna, Shashi P. Srivastava, Ashwini K. TI Enhancement of the energy storage properties of supercapacitors using graphene nanosheets dispersed with macro-structured porous copper oxide SO ELECTROCHIMICA ACTA LA English DT Article DE Macroporous copper oxide; Graphene nanosheets; Pseudocapacitor; Energy density ID ELECTRODE MATERIALS; CUO NANOSTRUCTURES; THIN-FILMS; PERFORMANCE; NANOCRYSTALLINE; SURFACTANT; CAPACITORS; IMPEDANCE; CELLS AB Graphene nanosheets (GN) dispersed with macroporous copper oxide (macroCuO) was investigated as an electrode material for supercapacitors. A facile and cost-effective synthesis approach was used to prepare macro-structured porous copper oxide monoliths via modified Sol-Gel route. 1, 3, 5-trimethylbenzene was used as an organic structural directing agent to enhance the pore size, pore volume, pore density and surface area of the resulting CuO hybrid templated with Pluronic P-123. GN/macroCuO nanocomposite was prepared by ultrasonication of the GN and macroCuO. The macroCuO and GN/macroCuO nanocomposite were characterized using various surface analytical techniques. Electrochemical performance of the composite electrode was investigated using cyclic voltammetry and chronopo-tentiometry. GN/macroCuO/GCE showed pseudocapacitance behaviour due to the Faradaic type of capacitance involving redox process between Cu (0) and Cu (II) of porous copper oxide network. Electrochemical measurements revealed the maximum specific capacitance, energy density and power density of 417 F g (1), 58 Wh kg (1) and 17.85 kW kg (1), respectively for the supercapacitor based on GN/ macroCuO nanocomposite electrode at a current density of 0.9 A g (1). The fabricated supercapacitor device exhibited excellent cycle life with 91.4% of the initial specific capacitance retained after 1000 cycles. The results suggest that the hybrid composite is a promising supercapacitor electrode material. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Dar, Riyaz A.; Kalambate, Pramod K.; Srivastava, Ashwini K.] Univ Bombay, Dept Chem, Bombay 400098, Maharashtra, India. [Naikoo, Gowhar A.; Khan, Farid] Dr Harisingh Gour Cent Univ, Dept Chem, Nanomat Discovery Lab, Sagar 470003, MP, India. [Giri, Lily; Karna, Shashi P.] US Army, Res Lab, Weap & Mat Res Lab, RDRL WM, Aberdeen Proving Ground, MD 21005 USA. RP Srivastava, AK (reprint author), Univ Bombay, Dept Chem, Bombay 400098, Maharashtra, India. EM aksrivastava@chem.mu.ac.in OI Dar, Riyaz/0000-0002-4494-0702; Naikoo, Gowhar/0000-0002-8237-3948 FU University Grants Commission, New Delhi, India; US Army International Technology Center, Tokyo, Japan [FA2386-12-1-4086] FX The funding for this work is partly by the University Grants Commission, New Delhi, India under its Dr. D. S. Kothari Post doctorate fellowship scheme (RAD) and partly by the US Army International Technology Center, Tokyo, Japan through contract number FA2386-12-1-4086. NR 54 TC 21 Z9 21 U1 10 U2 92 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0013-4686 EI 1873-3859 J9 ELECTROCHIM ACTA JI Electrochim. Acta PD MAY 1 PY 2015 VL 163 BP 196 EP 203 DI 10.1016/j.electacta.2015.02.123 PG 8 WC Electrochemistry SC Electrochemistry GA CF4CR UT WOS:000352496700026 ER PT J AU Whitehouse, CA Ladner, JT Palacios, GF AF Whitehouse, Chris A. Ladner, Jason T. Palacios, Gustavo F. TI Molecular characterization of plasmid pMoma1of Moraxella macacae, a newly described bacterial pathogen of macaques SO FOLIA MICROBIOLOGICA LA English DT Article ID ABORTIVE INFECTION; SEQUENCE-ANALYSIS; CATARRHALIS; BOVIS; DNA; CLASSIFICATION; CLONING; GENERA; FAMILY; ABID1 AB We report the complete nucleotide sequence and characterization of a small cryptic plasmid of Moraxella macacae 0408225, a newly described bacterial species within the family Moraxellaceae and a causative agent of epistaxis in macaques. The complete nucleotide sequence of the plasmid pMoma1 was determined and found to be 5,375 bp in size with a GC content of 37.4 %. Computer analysis of the sequence data revealed five open reading frames encoding putative proteins of 54.4 kDa (ORF1), 17.6 kDa (ORF2), 13.3 kDa (ORF3), 51.6 kDa (ORF4), and 25.0 kDa (ORF5). ORF1, ORF2, and ORF3 encode putative proteins with high identity (72, 42, and 55 %, respectively) to mobilization proteins of plasmids found in other Moraxella species. ORF3 encodes a putative protein with similarity (about 40 %) to several plasmid replicase (RepA) proteins. The fifth open reading frames (ORF) was most similar to hypothetical proteins with unknown functions, although domain analysis of this sequence suggests it belongs to the Abi-like protein family. Upstream of the repA gene, a 470-bp intergenic region, was identified that contained an AT-rich section and two sets of tandem direct and indirect repeats, consistent with a putative origin of replication site. In contrast to other plasmids of Moraxella, the occurrence of pMoma1 in M. macacae isolates appears to be common as PCR testing of 14 clinical isolates from two different research institutions all contained the plasmid. C1 [Whitehouse, Chris A.; Ladner, Jason T.; Palacios, Gustavo F.] US Army Med Res Inst Infect Dis, Ctr Genome Sci, Ft Detrick, MD USA. RP Whitehouse, CA (reprint author), US Army Med Res Inst Infect Dis, Mol & Translat Sci Div, Ft Detrick, MD 21702 USA. EM chris.a.whitehouse.ctr@mail.mil RI Palacios, Gustavo/I-7773-2015 OI Palacios, Gustavo/0000-0001-5062-1938 FU Defense Threat Reduction Agency [1881290] FX We thank Galina Koroleva and Marie Gestole for excellent technical support and Chih-Yuan Chiang for producing the plasmid diagram. The research described in this report was made possible by financial support provided by the Defense Threat Reduction Agency Project No. 1881290. NR 23 TC 0 Z9 0 U1 0 U2 4 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0015-5632 EI 1874-9356 J9 FOLIA MICROBIOL JI Folia Microbiol. PD MAY PY 2015 VL 60 IS 3 BP 235 EP 239 DI 10.1007/s12223-014-0364-9 PG 5 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA CF9PI UT WOS:000352897000006 PM 25398380 ER PT J AU Saboe, KN Taing, MU Way, JD Johnson, RE AF Saboe, Kristin N. Taing, Meng U. Way, Jason D. Johnson, Russell E. TI Examining the Unique Mediators That Underlie the Effects of Different Dimensions of Transformational Leadership SO JOURNAL OF LEADERSHIP & ORGANIZATIONAL STUDIES LA English DT Article DE transformational leadership; organizational commitment; leader-member exchange; organizational citizenship behavior; turnover intentions ID ORGANIZATIONAL CITIZENSHIP BEHAVIOR; ORDER MULTIDIMENSIONAL CONSTRUCTS; MEMBER EXCHANGE; SELF-CONCEPT; TRANSACTIONAL LEADERSHIP; CHARISMATIC LEADERSHIP; FAIRNESS PERCEPTIONS; AFFECTIVE COMMITMENT; FIELD EXPERIMENT; SOCIAL-EXCHANGE AB Although transformational leadership has been found to relate favorably to various work outcomes, past research has predominantly focused on overall transformational leadership rather than its dimensions. We addressed this shortcoming by examining how two dimensions of transformational leadershipproviding support and emphasizing group goalsrelate to follower organizational citizenship behavior and turnover intentions via leader-member exchange and employee commitment. Survey data were collected from 107 triads (employees, supervisors, and coworkers) employed in various organizations and industries. We supported our theoretical model in which the relation of providing support with organizational citizenship behavior is mediated by leader-member exchange and supervisor commitment, whereas the relationship of emphasizing group goals with turnover intentions is mediated by organizational commitment. These findings indicate that the dimensions of transformational leadership operate through unique channels. One implication for leadership development is that, depending on what outcome is desired (e.g., strengthening commitment to the leader vs. the organization), training can be tailored to target the most relevant dimension (e.g., providing support is more important for cultivating commitment to the leader vs. the organization). We discuss these and other implications of our findings. C1 [Saboe, Kristin N.] Walter Reed Army Inst Res, Alexandria, VA USA. [Taing, Meng U.] Univ S Florida, Ind & Org Psychol, Tampa, FL USA. [Way, Jason D.] ACT Inc, Iowa City, IA USA. [Johnson, Russell E.] Michigan State Univ, Eli Broad Coll Business, E Lansing, MI 48824 USA. RP Johnson, RE (reprint author), Michigan State Univ, Dept Management, North Business Coll Complex,632 Bogue St,Off N438, E Lansing, MI 48824 USA. EM johnsonr@broad.msu.edu NR 70 TC 2 Z9 2 U1 4 U2 25 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1548-0518 EI 1939-7089 J9 J LEADERSH ORG STUD JI J. Leadersh. Organ. Stud. PD MAY PY 2015 VL 22 IS 2 BP 175 EP 186 DI 10.1177/1548051814561028 PG 12 WC Management SC Business & Economics GA CF5FM UT WOS:000352582200004 ER PT J AU Quartana, PJ Wilk, JE Balkin, TJ Hoge, CW AF Quartana, Phillip J. Wilk, Joshua E. Balkin, Thomas J. Hoge, Charles W. TI Indirect associations of combat exposure with post-deployment physical symptoms in US soldiers: Roles of post-traumatic stress disorder, depression and insomnia SO JOURNAL OF PSYCHOSOMATIC RESEARCH LA English DT Article DE Combat exposure; Physical symptoms; PTSD; Insomnia; Depression; Pain; Military ID TRAUMATIC BRAIN-INJURY; COGNITIVE-BEHAVIORAL THERAPY; MENTAL-HEALTH PROBLEMS; IRAQ WAR VETERANS; PRIMARY-CARE; SOMATIC SYMPTOMS; NATIONAL-GUARD; SEVERITY INDEX; SLEEP DURATION; PTSD CHECKLIST AB Objective: To characterize the indirect associations of combat exposure with post-deployment physical symptoms through shared associations with post-traumatic stress disorder (PTSD), depression and insomnia symptoms. Methods: Surveys were administered to a sample of U.S. soldiers (N = 587) three months after a 15-month deployment to Iraq. A multiple indirect effects model was used to characterize direct and indirect associations between combat exposure and physical symptoms. Results: Despite a zero-order correlation between combat exposure and physical symptoms, the multiple indirect effects analysis did not provide evidence of a direct association between these variables. Evidence for a significant indirect association of combat exposure and physical symptoms was observed through PTSD, depression, and insomnia symptoms. In fact, 92% of the total effect of combat exposure on physical symptoms scores was indirect. These findings were evident even after adjusting for the physical injury and relevant demographics. Conclusion: This is the first empirical study to suggest that PTSD, depression and insomnia collectively and independently contribute to the association between combat exposure and post-deployment physical symptoms. Limitations, future research directions, and potential policy implications are discussed. Published by Elsevier Inc. C1 [Quartana, Phillip J.; Wilk, Joshua E.; Balkin, Thomas J.; Hoge, Charles W.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. RP Quartana, PJ (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM phillip.j.quartana2.civ@mail.mil FU U.S. Army Medical Research and Materiel Command (USAMRMC) FX The authors have no conflicts of interest to report. The U.S. Army Medical Research and Materiel Command (USAMRMC) provides intramural funding that supports enhancing the psychological resilience of the warfighter. NR 67 TC 1 Z9 1 U1 2 U2 11 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-3999 EI 1879-1360 J9 J PSYCHOSOM RES JI J. Psychosomat. Res. PD MAY PY 2015 VL 78 IS 5 BP 478 EP 483 DI 10.1016/j.jpsychores.2014.11.017 PG 6 WC Psychiatry SC Psychiatry GA CF9ZO UT WOS:000352926600011 PM 25499887 ER PT J AU Hill, SC Williamson, CC Doughty, DC Pan, YL Santarpia, JL Hill, HH AF Hill, Steven C. Williamson, Chatt C. Doughty, David C. Pan, Yong-Le Santarpia, Joshua L. Hill, Hanna H. TI Size-dependent fluorescence of bioaerosols: Mathematical model using fluorescing and absorbing molecules in bacteria SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article DE Fluorescence; Bioaerosols; Aerosol characterization; Light scattering ID BIOLOGICAL AEROSOL-PARTICLES; LASER-INDUCED FLUORESCENCE; METABOLITE CONCENTRATIONS; POTENTIAL INTERFERENCES; OPTICAL-PROPERTIES; ESCHERICHIA-COLI; BUOYANT DENSITY; UV-APS; SCATTERING; SPECTRA AB This paper uses a mathematical model of fluorescent biological particles composed of bacteria and/or proteins (mostly as in Hill et al., 2013 [23]) to investigate the size-dependence of the total fluorescence emitted in all directions. The model applies to particles which have negligible reabsorption of fluorescence within the particle. The specific particles modeled here are composed of ovalbumin and of a generic Bacillus. The particles need not be spherical, and in some cases need not be homogeneous. However, the results calculated in this paper are for spherical homogeneous particles. Light absorbing and fluorescing molecules included in the model are amino acids, nucleic acids, and several coenzymes. Here the excitation wavelength is 266 nm. The emission range, 300 to 370 nm, encompasses the fluorescence of tryptophan. The fluorescence cross section (C-F) is calculated and compared with one set of published measured values. We investigate power law (Ad(y)) approximations to C-F, where d is diameter, and A and y are parameters adjusted to fit the data, and examine how y varies with d and composition, including the fraction as water. The particle's fluorescence efficiency (Q(F)=C-F/geometric-cross-section) can be written for homogeneous particles as Q(abs)R(F), where Q(abs) is the absorption efficiency, and R-F, the fraction of the absorbed light emitted as fluorescence, is independent of size and shape. When Q(F) is plotted vs. m(i)d or m(i)(m(r)-1)d, where m=m(r)+im(i) is the complex refractive index, the plots for different fractions of water in the particle tend to overlap. Published by Elsevier Ltd. C1 [Hill, Steven C.; Williamson, Chatt C.; Doughty, David C.; Pan, Yong-Le] US Army, Res Lab, Adelphi, MD 20783 USA. [Santarpia, Joshua L.] Sandia Natl Labs, Albuquerque, NM USA. RP Hill, SC (reprint author), US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM steven.c.hill32.civ@mail.mil FU US Army Research Laboratory mission funds; Defense Threat Reduction Agency (DTRA) Basic and Supporting Science Program [HDT RA1-10-C-0023] FX Supported by US Army Research Laboratory mission funds and the Defense Threat Reduction Agency (DTRA) Basic and Supporting Science Program (contract HDT RA1-10-C-0023) NR 67 TC 3 Z9 3 U1 4 U2 25 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 EI 1879-1352 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD MAY PY 2015 VL 157 BP 54 EP 70 DI 10.1016/j.jqsrt.2015.01.011 PG 17 WC Optics; Spectroscopy SC Optics; Spectroscopy GA CG2CV UT WOS:000353083400005 ER PT J AU Sherwin, JS Muraskin, J Sajda, P AF Sherwin, Jason Samuel Muraskin, Jordan Sajda, Paul TI Pre-stimulus functional networks modulate task performance in time-pressured evidence gathering and decision-making SO NEUROIMAGE LA English DT Article DE Baseball; Decision-making; Functional magnetic resonance imaging; Functional connectivity; Graph-based networks; Machine learning ID SUPPLEMENTARY MOTOR AREA; PRESTIMULUS CORTICAL ACTIVITY; LATERAL OCCIPITAL COMPLEX; CEREBRAL-CORTEX; BRAIN NETWORKS; GRATING ORIENTATION; FEATURE-SELECTION; VISUAL-MOTION; FMRI; ORGANIZATION AB Rapid perceptual decision-making is believed to depend upon efficient allocation of neural resources to the processing of transient stimuliwithin task-relevant contexts. Given decision-making under severe time pressure, it is reasonable to posit that the brain configures itself, prior to processing stimulus information, in a way that depends upon prior beliefs and/or anticipation. However, relatively little is known about such configuration processes, how they might be manifested in the human brain, or ultimately how they mediate task performance. Here we show that network configuration, defined via pre-stimulus functional connectivity measures estimated from functional magnetic resonance imaging (fMRI) data, is predictive of performance in a time-pressured Go/No- Go task. Specifically, using connectivity measures to summarize network properties, we show that prestimulus brain state can be used to discriminate behaviorally correct and incorrect trials, as well as behaviorally correct commission and omission trial categories. More broadly, our results show that pre-stimulus functional configurations of cortical and sub-cortical networks can be a major determiner of task performance. (C) 2015 Elsevier Inc. All rights reserved. C1 [Sherwin, Jason Samuel; Muraskin, Jordan] Columbia Univ, Dept Biomed Engn, New York, NY 10027 USA. [Sherwin, Jason Samuel; Sajda, Paul] US Army Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Sherwin, JS (reprint author), Suny Downstate Med Ctr, Dept Ophthalmol, Martinez Conde Lab, 450 Clarkson Ave,MSC 58, Brooklyn, NY 11203 USA. EM jason.sherwin@downstate.edu; jsm2112@columbia.edu; psajda@columbia.edu OI Muraskin, Jordan/0000-0002-9913-4193 FU Army Research Office [W911NF-11-1-0219]; National Institutes of Health [R01-MH085092]; U.S. Army Research Laboratory [W911NF-10-2-0022] FX This work was supported by grants from the Army Research Office (W911NF-11-1-0219), the National Institutes of Health (R01-MH085092), the U.S. Army Research Laboratory under Cooperative Agreement Number W911NF-10-2-0022 and in part by an appointment to the U.S. Army Research Laboratory Postdoctoral Fellowship Program administered by the Oak Ridge Associated Universities through a contract with the U.S. Army Research Laboratory. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory of the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 81 TC 2 Z9 2 U1 4 U2 15 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1053-8119 EI 1095-9572 J9 NEUROIMAGE JI Neuroimage PD MAY 1 PY 2015 VL 111 BP 513 EP 525 DI 10.1016/j.neuroimage.2015.01.023 PG 13 WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA CF0HO UT WOS:000352224100045 PM 25614974 ER PT J AU Kiris, E Burnett, JC Nuss, JE Wanner, LM Peyser, BD Du, HT Gomba, GY Kota, KP Panchal, RG Gussio, R Kane, CD Tessarollo, L Bavari, S AF Kiris, Erkan Burnett, James C. Nuss, Jonathan E. Wanner, Laura M. Peyser, Brian D. Du, Hao T. Gomba, Glenn Y. Kota, Krishna P. Panchal, Rekha G. Gussio, Rick Kane, Christopher D. Tessarollo, Lino Bavari, Sina TI Src Family Kinase Inhibitors Antagonize the Toxicity of Multiple Serotypes of Botulinum Neurotoxin in Human Embryonic Stem Cell-Derived Motor Neurons SO NEUROTOXICITY RESEARCH LA English DT Article DE Motor neurons; Human embryonic stem cells; Src inhibitors; Botulinum neurotoxins; Cell-based assay; Drug discovery ID TYROSINE PHOSPHORYLATION; SYNAPTIC-VESICLE; DIRECTED DIFFERENTIATION; CLOSTRIDIAL NEUROTOXINS; CATALYTIC DOMAIN; RECEPTOR; SNAP-25; BINDING; METALLOPROTEASE; STABILIZATION AB Botulinum neurotoxins (BoNTs), the causative agents of botulism, are potent inhibitors of neurotransmitter release from motor neurons. There are currently no drugs to treat BoNT intoxication after the onset of the disease symptoms. In this study, we explored how modulation of key host pathways affects the process of BoNT intoxication in human motor neurons, focusing on Src family kinase (SFK) signaling. Motor neurons derived from human embryonic stem (hES) cells were treated with a panel of SFK inhibitors and intoxicated with BoNT serotypes A, B, or E (which are responsible for > 95 % of human botulism cases). Subsequently, it was found that bosutinib, dasatinib, KX2-391, PP1, PP2, Src inhibitor-1, and SU6656 significantly antagonized all three of the serotypes. Furthermore, the data indicated that the treatment of hES-derived motor neurons with multiple SFK inhibitors increased the antagonistic effect synergistically. Mechanistically, the small molecules appear to inhibit BoNTs by targeting host pathways necessary for intoxication and not by directly inhibiting the toxins' proteolytic activity. Importantly, the identified inhibitors are all well-studied with some in clinical trials while others are FDA-approved drugs. Overall, this study emphasizes the importance of targeting host neuronal pathways, rather than the toxin's enzymatic components, to antagonize multiple BoNT serotypes in motor neurons. C1 [Kiris, Erkan] Geneva Fdn, Tacoma, WA 98402 USA. [Kiris, Erkan; Nuss, Jonathan E.; Wanner, Laura M.; Gomba, Glenn Y.; Kota, Krishna P.; Panchal, Rekha G.; Kane, Christopher D.; Bavari, Sina] US Army Med Res Inst Infect Dis, Dept Mol & Translat Sci, Frederick, MD 21702 USA. [Kiris, Erkan; Du, Hao T.; Tessarollo, Lino] NCI, Neural Dev Sect, Mouse Canc Genet Program, Ctr Canc Res, Frederick, MD 21702 USA. [Burnett, James C.] NCI, Leidos Biomed Res Inc, CDDG, Frederick, MD 21702 USA. [Burnett, James C.; Peyser, Brian D.; Gussio, Rick] NCI, CDDG, Dev Therapeut Program, Frederick, MD 21702 USA. [Kane, Christopher D.] Henry M Jackson Fdn, Bethesda, MD USA. [Kane, Christopher D.] USAMRMC, DoD Biotechnol High Performance Comp Software App, TATRC, Frederick, MD USA. RP Kiris, E (reprint author), Geneva Fdn, Tacoma, WA 98402 USA. EM erkan.kiris@nih.gov; sina.bavari.civ@mail.mil OI Peyser, Brian/0000-0002-3455-5181 FU Defense Threat Reduction Agency; National Institutes of Health [4R33AI101387 - 03]; National Cancer Institute (NCI), National Institutes of Health (NIH) [HHSN261200800001E]; Intramural Research Program of the NCI, Center for Cancer Research, NIH FX We are indebted to Drs. Esta Sterneck and Balamurugan Kuppusamy for their insightful discussion concerning SFK inhibitors. Also, we thank Rajarshi Guha for R functions to optimize beta for synergy calculations, and Veronica Soloveva for helpful discussion. This research was supported by grants from the Defense Threat Reduction Agency and National Institutes of Health (4R33AI101387 - 03). For JCB, this project has been funded in whole or in part with federal funds from the National Cancer Institute (NCI), National Institutes of Health (NIH), under contract no. HHSN261200800001E. LT has been supported by the Intramural Research Program of the NCI, Center for Cancer Research, NIH. NR 81 TC 5 Z9 5 U1 1 U2 11 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1029-8428 EI 1476-3524 J9 NEUROTOX RES JI Neurotox. Res. PD MAY PY 2015 VL 27 IS 4 BP 384 EP 398 DI 10.1007/s12640-015-9526-z PG 15 WC Neurosciences SC Neurosciences & Neurology GA CF1IR UT WOS:000352298900003 PM 25782580 ER PT J AU Valkeapaa, AI Yamashita, H Jayakumar, P Sugiyama, H AF Valkeapaa, Antti I. Yamashita, Hiroki Jayakumar, Paramsothy Sugiyama, Hiroyuki TI On the use of elastic middle surface approach in the large deformation analysis of moderately thick shell structures using absolute nodal coordinate formulation SO NONLINEAR DYNAMICS LA English DT Article DE Flexible multibody dynamics; Absolute nodal coordinate formulation; Large deformation; Shell element ID OPTIMAL SOLID SHELLS; FINITE-ELEMENTS; PLATE ELEMENT; MULTILAYER COMPOSITES; SYSTEM APPLICATIONS; INCOMPATIBLE MODES; NONLINEAR ANALYSES; INTERPOLATION; FORCES AB In this study, a shear deformable shell element is developed based on the elastic middle surface approach using the absolute nodal coordinate formulation (ANCF) for the large deformation analysis of thin to moderately thick shell structures. The bilinear shape function is used to define the global position vector in the middle surface and the transverse gradient vector which defines the orientation and deformation of the cross section within the element. The plane stress assumption is used to remedy the Poisson's thickness locking exhibited in the ANCF shell element formulated by the continuum mechanics approach, thus the stress distribution along the shell thickness is assumed to be constant. The cross-sectional frame is introduced to define strains of the initially curved shell element using the elastic middle surface approach. The curvature thickness and transverse shear lockings are alleviated using the assumed natural strain method, while the in-plane shear locking is removed using the enhanced assumed strain method. Several numerical examples are presented in order to demonstrate the performance of the shear deformable ANCF shell element based on the elastic middle surface approach developed in this study. The developed element is compared with the continuum mechanics-based ANCF shell element to shed light on the nature of the thickness locking exhibited in the bilinear shell element and its locking remedies. C1 [Valkeapaa, Antti I.] Lappeenranta Univ Technol, Dept Mech Engn, Lappeenranta 53850, Finland. [Yamashita, Hiroki; Sugiyama, Hiroyuki] Univ Iowa, Dept Mech & Ind Engn, Iowa City, IA 52242 USA. [Jayakumar, Paramsothy] US Army RDECOM TARDEC, Warren, MI 48397 USA. RP Sugiyama, H (reprint author), Univ Iowa, Dept Mech & Ind Engn, Iowa City, IA 52242 USA. EM antti.valkeapaa@lut.fi; hiroki-yamashita@uiowa.edu; paramsothy.jayakumar.civ@mail.mil; hiroyuki-sugiyama@uiowa.edu FU Automotive Research Center (ARC) [W56HZV-04-2-0001]; National Graduate School in Engineering Mechanics, Finland; Academy of Finland [138574]; FunctionBay Inc. FX This research is supported by the Automotive Research Center (ARC) in accordance with Cooperative Agreement W56HZV-04-2-0001 U.S. Army Tank Automotive Research, Development and Engineering Center (TARDEC). The support of first author by the National Graduate School in Engineering Mechanics, Finland and the Academy of Finland (#138574) is acknowledged. Financial support for the last author received from FunctionBay Inc. is also acknowledged. NR 50 TC 1 Z9 2 U1 1 U2 12 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0924-090X EI 1573-269X J9 NONLINEAR DYNAM JI Nonlinear Dyn. PD MAY PY 2015 VL 80 IS 3 BP 1133 EP 1146 DI 10.1007/s11071-015-1931-6 PG 14 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA CF6VJ UT WOS:000352694300005 ER PT J AU Das, NC AF Das, N. C. TI Enhanced solar energy harvesting using top n-contact GaAs solar cell SO SOLID-STATE ELECTRONICS LA English DT Article DE GaAs solar cell; Top contacts; Efficiency; Enhanced solar power ID EFFICIENCY AB We fabricated single-junction solar cell on molecular beam epitaxially grown p-n junction on n-type gallium arsenide (GaAs) substrate. We used a germanium (Ge)/gold (Au)/nickel (Ni)/Au metal contact from the top side on a highly doped n+ epitaxial layer as well as the bottom side on an n-type GaAs substrate. We observed 10-15% increase in solar cell power when the top contact is used for the n+ GaAs epi layer compared to the bottom side n-type GaAs substrate. Solar cell fill factor, sheet, and shunt resistances are same for both the top and bottom contact type devices. We also observed higher external quantum efficiency (EQE) for top contact devices compared to bottom contact devices. We conclude that to achieve higher power, it is advantageous to use an n-type contact from a highly doped top n+ epitaxial layer rather than a bottom n-type GaAs substrate. Published by Elsevier Ltd. C1 Army Res Lab, Microphoton Branch, Adelphi, MD 20783 USA. RP Das, NC (reprint author), Army Res Lab, Microphoton Branch, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM Naresh.c.das2.civ@mail.mil NR 9 TC 0 Z9 0 U1 5 U2 14 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0038-1101 EI 1879-2405 J9 SOLID STATE ELECTRON JI Solid-State Electron. PD MAY PY 2015 VL 107 BP 11 EP 14 DI 10.1016/j.sse.2015.02.015 PG 4 WC Engineering, Electrical & Electronic; Physics, Applied; Physics, Condensed Matter SC Engineering; Physics GA CF6LU UT WOS:000352669000003 ER PT J AU Sharaiha, RZ Tyberg, A Khashab, M Karia, K Siddiqui, UD Waxman, I Joshi, V Benias, PC Darwin, P Dimaio, CJ Mulder, C Friedland, S Forcione, DG Sejpal, DV Gonda, TA Gress, FG Gaidhane, M Koons, A Defilippis, EM Salgado, S Weaver, KR Poneros, JM Sethi, A Ho, S Kumbhari, V Singh, VK Tieu, AH Likhitsup, A Womeldorph, C Casey, B Jonnalagadda, SS Desai, AP Carr-Locke, DL Kahaleh, M Siddiqui, A AF Sharaiha, Reem Z. Tyberg, Amy Khashab, Mouen Karia, Kunal Siddiqui, Uzma D. Waxman, Irving Joshi, Virendra Benias, Petros C. Darwin, Peter Dimaio, Christopher J. Mulder, Christopher Friedland, Shai Forcione, David G. Sejpal, Divyesh V. Gonda, Tamas A. Gress, Frank G. Gaidhane, Monica Koons, Ann Defilippis, Ersilia M. Salgado, Sanjay Weaver, Kristen R. Poneros, John M. Sethi, Amrita Ho, Sammy Kumbhari, Vivek Singh, Vikesh K. Tieu, Alan H. Likhitsup, Alisa Womeldorph, Craig Casey, Brenna Jonnalagadda, Sreeni S. Desai, Amit P. Carr-Locke, David L. Kahaleh, Michel Siddiqui, Ali TI Multicenter Experience With a Lumen Apposing Stent for Walled-Off Pancreatic Necrosis (WOPN): the US Experience SO GASTROINTESTINAL ENDOSCOPY LA English DT Meeting Abstract CT 46th Annual Digestive Diseases Week (DDW) / Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Annual Meeting of the American-Society-for-Gastrointestinal-Endoscopy (ASGE) CY MAY 16-19, 2015 CL Washington, DC SP Amer Assoc Study Liver Dis, Amer Gastroenterol Assoc, Amer Soc Gastrointestinal Endoscopy, Soc Surg Alimentary Tract C1 [Sharaiha, Reem Z.; Tyberg, Amy; Karia, Kunal; Gaidhane, Monica; Defilippis, Ersilia M.; Salgado, Sanjay; Weaver, Kristen R.; Desai, Amit P.; Kahaleh, Michel] Weill Cornell Med Ctr, Gastroenterol & Hepatol, New York, NY USA. [Khashab, Mouen; Kumbhari, Vivek; Singh, Vikesh K.; Tieu, Alan H.] Johns Hopkins Med Inst, Gastroenterol & Hepatol, Baltimore, MD 21205 USA. [Siddiqui, Uzma D.; Waxman, Irving; Koons, Ann] Univ Chicago, Gastroenterol & Hepatol, Chicago, IL 60637 USA. [Gonda, Tamas A.; Gress, Frank G.; Poneros, John M.; Sethi, Amrita] Columbia Univ, Med Ctr, Gastroenterol & Hepatol, New York, NY USA. [Friedland, Shai] Stanford Hosp & Clin, Gastroenterol & Hepatol, Palo Alto, CA USA. [Joshi, Virendra] Ochsner Hlth Syst, Gastroenterol & Hepatol, New Orleans, LA USA. [Benias, Petros C.; Carr-Locke, David L.] Beth Israel Mt Sinai, Gastroenterol & Hepatol, New York, NY USA. [Darwin, Peter] Univ Maryland, Gastroenterol & Hepatol, Baltimore, MD 21201 USA. [Siddiqui, Ali] Jefferson Univ, Gastroenterol & Hepatol, Philadelphia, PA USA. [Dimaio, Christopher J.] Mt Sinai Med Ctr, Gastroenterol & Hepatol, New York, NY 10029 USA. [Ho, Sammy] Montifiore, Gastroenterol & Hepatol, New York, NY USA. [Forcione, David G.; Casey, Brenna] Harvard Med Sch, Massachusetts Gen Hosp, Gastorenterol & Hepatol, Boston, MA USA. [Mulder, Christopher; Womeldorph, Craig] Brooke Army Med Ctr, Gastroenterol & Hepatol, Ft Sam Houston, TX 78234 USA. [Sejpal, Divyesh V.] Long Isl Jewish North Shore, Gastroenterol & Hepatol, New York, NY USA. [Likhitsup, Alisa; Jonnalagadda, Sreeni S.] Univ Missouri, Gastroenterol & Hepatol, Kansas City, MO 64110 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0016-5107 EI 1097-6779 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD MAY PY 2015 VL 81 IS 5 SU S MA 708 BP AB161 EP AB162 PG 4 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA DS4PS UT WOS:000380763600112 ER PT J AU Cohen, C Morazzani, E Kalinyak, L Glass, P AF Cohen, Courtney Morazzani, Elaine Kalinyak, Laura Glass, Pamela TI T cell-mediated protection and epitope mapping with a trivalent alphavirus-like replicon particle vaccine SO JOURNAL OF IMMUNOLOGY LA English DT Meeting Abstract CT Annual Meeting of the American-Association-of-Immunologists (IMMUNOLOGY) CY MAY 08-12, 2015 CL New Orleans, LA SP Amer Assoc Immunologists C1 [Cohen, Courtney; Morazzani, Elaine; Kalinyak, Laura; Glass, Pamela] US Army Med Res Inst Infect Dis, Virol, Frederick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 EI 1550-6606 J9 J IMMUNOL JI J. Immunol. PD MAY 1 PY 2015 VL 194 SU 1 MA VIR2P.1167 PG 1 WC Immunology SC Immunology GA DQ7RG UT WOS:000379404502195 ER PT J AU Kannan, L Tsokos, M Lucca, JD Tsokos, G AF Kannan, Lakshmi Tsokos, Maria Lucca, Jurandir Daile Tsokos, George TI Intracellular activation of complement 3 mediates intestinal tissue damage during mesenteric ischemia SO JOURNAL OF IMMUNOLOGY LA English DT Meeting Abstract CT Annual Meeting of the American-Association-of-Immunologists (IMMUNOLOGY) CY MAY 08-12, 2015 CL New Orleans, LA SP Amer Assoc Immunologists C1 [Kannan, Lakshmi; Tsokos, Maria; Tsokos, George] Harvard Med Sch, BIDMC, Boston, MA USA. [Lucca, Jurandir Daile] US Army Inst Surg Res, Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 EI 1550-6606 J9 J IMMUNOL JI J. Immunol. PD MAY 1 PY 2015 VL 194 SU 1 MA INC1P.356 PG 1 WC Immunology SC Immunology GA DQ7RG UT WOS:000379404503143 ER PT J AU Kim, A Hartman, I Lanar, D Boronina, T Cole, R Sadegh-Nasseri, S AF Kim, Ae Hartman, Isamu Lanar, David Boronina, Tatiana Cole, Robert Sadegh-Nasseri, Scheherazade TI The hierarchy of two different immunodominant epitopes influences CD4(+) T cell responses SO JOURNAL OF IMMUNOLOGY LA English DT Meeting Abstract CT Annual Meeting of the American-Association-of-Immunologists (IMMUNOLOGY) CY MAY 08-12, 2015 CL New Orleans, LA SP Amer Assoc Immunologists C1 [Kim, Ae; Boronina, Tatiana; Cole, Robert] Johns Hopkins Univ, Baltimore, MD USA. [Hartman, Isamu] UT Southwestern Med Ctr, Dallas, TX USA. [Lanar, David] Walter Reed Army Inst Res, Mol Engn, Sinver Spring, MD USA. [Sadegh-Nasseri, Scheherazade] Johns Hopkins Univ, Sch Med, Pathol, Baltimore, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 EI 1550-6606 J9 J IMMUNOL JI J. Immunol. PD MAY 1 PY 2015 VL 194 SU 1 MA APP5P.112 PG 2 WC Immunology SC Immunology GA DQ7RG UT WOS:000379404500133 ER PT J AU Laird, R Shahabudin, S Clarkson, K Kaminski, R Savarino, S Riddle, M Gutierrez, R Maciel, M AF Laird, Renee Shahabudin, Sakina Clarkson, Kristen Kaminski, Robert Savarino, Stephen Riddle, Mark Gutierrez, Ramiro Maciel, Milton TI Memory B cells with gut-homing potential are generated by a prototype anti-enterotoxigenic E. coli vaccine given by intradermal immunization with LT(R192G) as an adjuvant SO JOURNAL OF IMMUNOLOGY LA English DT Meeting Abstract CT Annual Meeting of the American-Association-of-Immunologists (IMMUNOLOGY) CY MAY 08-12, 2015 CL New Orleans, LA SP Amer Assoc Immunologists C1 [Laird, Renee; Shahabudin, Sakina; Savarino, Stephen; Riddle, Mark; Gutierrez, Ramiro; Maciel, Milton] Naval Med Res Ctr, Enter Dis Dept, Silver Spring, MD USA. [Clarkson, Kristen; Kaminski, Robert] Walter Reed Army Inst Res, Subunit Enter Vaccines & Immunol, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 EI 1550-6606 J9 J IMMUNOL JI J. Immunol. PD MAY 1 PY 2015 VL 194 SU 1 MA MUC3P.945 PG 1 WC Immunology SC Immunology GA DQ7RG UT WOS:000379404502125 ER PT J AU Sager, JL AF Sager, James L. TI Generations of Soldiers SO ARCHAEOLOGY LA English DT Letter C1 [Sager, James L.] US Army, Muskegon, MI USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ARCHAEOLOGICAL INST AMERICA PI BOSTON PA 656 BEACON STREET, BOSTON, MA 02215 USA SN 0003-8113 EI 1943-5746 J9 ARCHAEOLOGY JI Archaeology PD MAY-JUN PY 2015 VL 68 IS 3 BP 8 EP 8 PG 1 WC Archaeology SC Archaeology GA CF1VJ UT WOS:000352335700007 ER PT J AU Bailey, AM Christopher, JJ Salzar, RS Brozoski, F AF Bailey, Ann Marie Christopher, John J. Salzar, Robert S. Brozoski, Frederick TI Comparison of Hybrid-III and Postmortem Human Surrogate Response to Simulated Underbody Blast Loading SO JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME LA English DT Article ID HUMAN JOINT MOTION; ISB RECOMMENDATION; INJURY; DEFINITIONS AB Response of the human body to high-rate vertical loading, such as military vehicle under-body blast (UBB), is not well understood because of the chaotic nature of such events. The purpose of this research was to compare the response of postmortem human surrogates (PMHS) and the Hybrid-III anthropomorphic test device (ATD) to simulated UBB loading ranging from 100 to 860 g seat and floor acceleration. Data from 13 whole body PMHS tests were used to create response corridors for vertical loading conditions for the pelvis, T1, head, femur, and tibia; these responses were compared to Hybrid-III responses under matched loading conditions. C1 [Bailey, Ann Marie; Christopher, John J.; Salzar, Robert S.] Univ Virginia, Charlottesville, VA 22911 USA. [Brozoski, Frederick] US Army Aeromed Res Lab, Ft Rucker, AL 36362 USA. RP Bailey, AM (reprint author), Univ Virginia, 4040 Lewis & Clark Dr, Charlottesville, VA 22911 USA. EM amb9um@virginia.edu; jjc2c@virginia.edu; rss2t@virginia.edu; frederick.brozoski@us.army.mil FU U.S. Department of Defense (DOD) [W81XWH-11-2-0086]; U.S. Army Medical Research and Materiel Command (MRMC); U.S. Army Aeromedical Research Laboratory (USAARL) FX This research was funded by the U.S. Department of Defense (DOD) Contract No. W81XWH-11-2-0086 and the U.S. Army Medical Research and Materiel Command (MRMC) and the U.S. Army Aeromedical Research Laboratory (USAARL). NR 30 TC 0 Z9 0 U1 1 U2 3 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0148-0731 EI 1528-8951 J9 J BIOMECH ENG-T ASME JI J. Biomech. Eng.-Trans. ASME PD MAY PY 2015 VL 137 IS 5 AR 051009 DI 10.1115/1.4029981 PG 10 WC Biophysics; Engineering, Biomedical SC Biophysics; Engineering GA CF0YQ UT WOS:000352271000009 PM 25751733 ER PT J AU Hall, CA Lydon, HL Dalton, CH Chipman, JK Graham, JS Chilcott, RP AF Hall, Charlotte A. Lydon, Helen L. Dalton, Christopher H. Chipman, J. K. Graham, John S. Chilcott, Robert P. TI Development of haemostatic decontaminants for the treatment of wounds contaminated with chemical warfare agents. 1: Evaluation of in vitro clotting efficacy in the presence of certain contaminants SO JOURNAL OF APPLIED TOXICOLOGY LA English DT Article DE thrombelastography; toxic industrial chemicals; chemical warfare agents; haemostasis; decontamination ID EXTREMITY ARTERIAL HEMORRHAGE; HEPATIC-INJURY; VENOUS HEMORRHAGE; TISSUE FACTOR; GROIN INJURY; ANIMAL-MODEL; SWINE MODEL; BLOOD; COAGULATION; DRESSINGS AB The treatment of penetrating, haemorrhaging injuries sustained within a hazardous environment may be complicated by contamination with toxic chemicals. There are currently no specific medical countermeasures for such injuries. Haemostats with an absorbent mechanism of action have the potential to simultaneously stop bleeding and decontaminate wounds. However, a primary requirement of a haemostatic decontaminant' is the retention of clotting function in the presence of chemical contaminants. Thus, the aim of this study was to investigate the haemostatic efficacy of seven commercially available haemostats in the presence of toxic chemicals (soman, VX, sulphur mustard, petrol, aviation fuel and motor oil). Clot viscosity was assessed ex vivo using thrombelastography following treatment of pig blood with: (i) toxic chemical; (ii) haemostat; or (iii) haemostat in combination with toxic chemical. Several contaminants (VX, petrol and GD) were found to be pro-haemostatic and none had an adverse effect on the rate with which the test products attained haemostasis. However, the total clot strength for blood treated with certain haemostats in the presence of sulphur mustard, soman and petrol was significantly decreased. Three test products failed to demonstrate haemostatic function in this ex vivo (thrombelastography) model; this was tentatively ascribed to the products achieving haemostasis through a tamponade mechanism of action, which can only be replicated using in vivo models. Overall, this study has identified a number of commercial products that may have potential as haemostatic decontaminants and warrant further investigation to establish their decontaminant efficacy. Copyright (c) 2014 John Wiley & Sons, Ltd. The treatment of battlefield injuries may be complicated by contamination with toxic chemicals. The aim of this study was to investigate the ex vivo haemostatic efficacy of seven commercially available haemostats in the presence of toxic chemicals (soman, VX, sulphur mustard, petrol, aviation fuel and motor oil). A number of commercial products which may have potential as haemostatic decontaminants were identified which warrant further investigation to establish their decontaminant efficacy. C1 [Hall, Charlotte A.; Lydon, Helen L.; Chilcott, Robert P.] Hlth Protect Agcy, CBRN, Chilton, England. [Hall, Charlotte A.; Lydon, Helen L.; Chilcott, Robert P.] Hlth Protect Agcy, Chem Toxicol Res Grp, Ctr Radiat Chem & Environm Hazards, Chilton, England. [Hall, Charlotte A.; Lydon, Helen L.; Dalton, Christopher H.; Chipman, J. K.] Univ Birmingham, Sch Biosci, Birmingham, W Midlands, England. [Dalton, Christopher H.] Dstl Porton Down, Biomed Sci, Salisbury, Wilts, England. [Graham, John S.] US Army Med Res Inst Chem Def, Med Toxicol Branch, Analyt Toxicol Div, Aberdeen Proving Ground, MD 21010 USA. [Chilcott, Robert P.] Univ Hertfordshire, Dept Pharm, Hatfield AL10 9AB, Herts, England. RP Chilcott, RP (reprint author), Univ Hertfordshire, Dept Pharm, Hatfield AL10 9AB, Herts, England. EM r.chilcott@herts.ac.uk RI Dalton, Christopher/J-5747-2016; OI Dalton, Christopher/0000-0001-7021-781X; Hall, Charlotte/0000-0002-3670-9463 FU 'Haemostatic Decontaminants for Penetrating Injuries Contaminated with CW Agents' project - Defense Threat Reduction Agency [2.F0026_08_RC_C] FX This work was performed by the Health Protection Agency at facilities operated by the Defence Science and Technology Laboratory in support of the 'Haemostatic Decontaminants for Penetrating Injuries Contaminated with CW Agents' project sponsored by the Defense Threat Reduction Agency (project ID number 2.F0026_08_RC_C). The authors wish to thank the Dstl Detection Department for the provision of CW agents and staff at QinetiQ (Boscombe Down) for providing samples of jet fuel. NR 39 TC 1 Z9 1 U1 1 U2 105 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0260-437X EI 1099-1263 J9 J APPL TOXICOL JI J. Appl. Toxicol. PD MAY PY 2015 VL 35 IS 5 BP 536 EP 542 DI 10.1002/jat.3019 PG 7 WC Toxicology SC Toxicology GA CE2XF UT WOS:000351684300011 PM 25131713 ER PT J AU Mummert, C Saadaoui, A Sovine, S AF Mummert, Carl Saadaoui, Alaeddine Sovine, Sean TI The modal logic of Reverse Mathematics SO ARCHIVE FOR MATHEMATICAL LOGIC LA English DT Article DE Mathematics; Modal logic; Strict implication; Automated reasoning AB The implication relationship between subsystems in Reverse Mathematics has an underlying logic, which can be used to deduce certain new Reverse Mathematics results from existing ones in a routine way. We use techniques of modal logic to formalize the logic of Reverse Mathematics into a system that we name s-logic. We argue that s-logic captures precisely the "logical" content of the implication and nonimplication relations between subsystems in Reverse Mathematics. We present a sound, complete, decidable, and compact tableau-style deductive system for s-logic, and explore in detail two fragments that are particularly relevant to Reverse Mathematics practice and automated theorem proving of Reverse Mathematics results. C1 [Mummert, Carl; Saadaoui, Alaeddine] Marshall Univ, Huntington, WV 25755 USA. [Sovine, Sean] US Army Corps Engineers, Washington, DC USA. RP Mummert, C (reprint author), Marshall Univ, 1 John Marshall Dr, Huntington, WV 25755 USA. EM mummertc@marshall.edu NR 9 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 0933-5846 EI 1432-0665 J9 ARCH MATH LOGIC JI Arch. Math. Log. PD MAY PY 2015 VL 54 IS 3-4 BP 425 EP 437 DI 10.1007/s00153-015-0417-z PG 13 WC Mathematics; Logic SC Mathematics; Science & Technology - Other Topics GA CE0RF UT WOS:000351511600007 ER PT J AU Head, J Helton, WS AF Head, James Helton, William S. TI Passive perceptual learning versus active searching in a novel stimuli vigilance task SO EXPERIMENTAL BRAIN RESEARCH LA English DT Article DE Cognitive effort; Mental workload; Perceptual learning; Sustained attention; Tracking; Vigilance ID BLOOD-FLOW VELOCITY; SUSTAINED ATTENTION; CEREBRAL HEMOVELOCITY; RESPONSE-INHIBITION; PERFORMANCE; ENGAGEMENT; RESOURCES; WORKLOAD; BREAKS AB A criticism of laboratory vigilance or sustained attention research is the employment of static monotonous tasks with repetitive targets as opposed to the use of dynamic tasks with novel target stimuli. Unfortunately dynamic tasks employing novel stimuli may result in the mixture of two cognitive processes: active sustained attention search and passive perceptual learning. Moreover, the relative engagement of these two processes may depend on individual differences. In the present study, we examined this by having participants perform a dynamic auditory vigilance task with rare novel targets. In addition, some participants performed this task while also performing a secondary motor tracking task, a dual-task scenario. In the dual-task scenario, participants who failed to accurately detect the first target stimuli showed improvements in their tracking performance with time-on-task, suggesting reserves of attention. This improvement in tracking performance was not evident for those who accurately detected the first target stimuli, as their attention was likely actively engaged (searching). In addition, participants in the dual-task scenario who accurately detected the first target stimuli reported high workload and increased post-task tense arousal, results characteristic of participants performing static vigilance tasks. These results indicate the possibility that in a dynamic vigilance task with novel target stimuli participants may diverge in how they approach the task. Some participants will actively monitor the display for targets (search), whereas others will passively learn the target stimuli. Thus, these tasks may pose significant challenges to researchers who wish to examine vigilance in isolation from perceptual learning. C1 [Head, James] US Army, Res Lab, Human Res & Engn Directorate, RDRL HRS E, Aberdeen Proving Ground, MD 21005 USA. [Helton, William S.] Univ Canterbury, Dept Psychol, Christchurch 1, New Zealand. RP Helton, WS (reprint author), Univ Canterbury, Dept Psychol, Private Bag 4800, Christchurch 1, New Zealand. EM Deak.Helton@canterbury.ac.nz NR 59 TC 3 Z9 3 U1 4 U2 8 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0014-4819 EI 1432-1106 J9 EXP BRAIN RES JI Exp. Brain Res. PD MAY PY 2015 VL 233 IS 5 BP 1481 EP 1489 DI 10.1007/s00221-015-4222-z PG 9 WC Neurosciences SC Neurosciences & Neurology GA CE0SJ UT WOS:000351515800013 PM 25694244 ER PT J AU Simingalam, S Brill, G Wijewarnasuriya, P Rao, MV AF Simingalam, Sina Brill, Gregory Wijewarnasuriya, Priyalal Rao, Mulpuri V. TI Low Temperature, Rapid Thermal Cycle Annealing of HgCdTe Grown on CdTe/Si SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT 56th Electronic Materials Conference CY JUN 25-27, 2014 CL Univ Calif Santa Barbara, Santa Barbara, CA SP Amer Elements, Sandia Natl Labs HO Univ Calif Santa Barbara DE HgCdTe; thermal cycle annealing; dislocation; diffusion ID DISLOCATIONS; REDUCTION; GAAS AB The HgCdTe(MCT) grown on CdTe/Si substrate has a high dislocation density due to lattice mismatch. Thermal cycle annealing (TCA) is effective in reducing the dislocation density. The TCA at high temperatures results in inter-diffusion of the constituent elements across the MCT/CdTe interface. Ina this pound study, we observed a reduction in dislocation density with good surface morphology due to proper design of the TCA system, low annealing temperature, and large number of annealing cycles. The ampoule containing the samples is placed in direct contact with the graphite heating tube which helps in increasing the heating and cooling rates of the annealing cycle. To maintain Hg overpressure, Hg is placed in the sample holder, instead of in the ampoule to avoid Hg condensation. The best results were obtained by cycling the annealing temperature between 290A degrees C and 350A degrees C. Anneals were performed by using 32, 64, 128 and 256 cycles. We obtained an etch pit density (EPD) as low as 1 x 10(6) cm(-2). Lower EPD was not achieved either by increasing annealing temperature or number of annealing cycles. Through secondary ion mass spectroscopy analysis, we observed very little inter-diffusion of Cd across the MCT/CdTe interface for the 128 cycle annealing. These results show promise in bridging the gap in the device performance between the MCT material grown on CdTe/Si and CdZnTe substrates. C1 [Simingalam, Sina] George Mason Univ, Sch Phys Astron & Computat Sci, Fairfax, VA 22030 USA. [Simingalam, Sina; Brill, Gregory; Wijewarnasuriya, Priyalal] US Army Res Lab, Adelphi, MD USA. [Simingalam, Sina; Rao, Mulpuri V.] George Mason Univ, Dept Elect & Comp Engn, Fairfax, VA 22030 USA. RP Simingalam, S (reprint author), George Mason Univ, Sch Phys Astron & Computat Sci, Fairfax, VA 22030 USA. EM ssiminga@gmu.edu; gregory.n.brill.civ@mail.mil; priyalal.wijewarnasuriya@us.army.mil; rmulpuri@gmu.edu FU Defense Advanced Research Projects Agency (DARPA) through Army Research Office (ARO) [W911NF-11-2-0049] FX The authors would like to thank Defense Advanced Research Projects Agency (DARPA) for funding through Army Research Office (ARO) contract #W911NF-11-2-0049. NR 16 TC 1 Z9 1 U1 1 U2 12 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 EI 1543-186X J9 J ELECTRON MATER JI J. Electron. Mater. PD MAY PY 2015 VL 44 IS 5 BP 1321 EP 1326 DI 10.1007/s11664-014-3542-2 PG 6 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA CE2RH UT WOS:000351663100011 ER PT J AU Xie, KY Livi, K McCauley, JW Hemker, KJ AF Xie, Kelvin Y. Livi, Kenneth McCauley, James W. Hemker, Kevin J. TI Precipitation of AlN in a commercial hot-pressed boron carbide SO SCRIPTA MATERIALIA LA English DT Article DE Boron carbide; Precipitates; Aluminum nitride; Transmission electron microscopy ID MECHANICAL-PROPERTIES; COMPOSITES; B4C; TIO2 AB TEM observations have provided insight into the processing and microstructural evolution of a commercial hot-pressed boron carbide. Fine dispersions of nano-scale AlN precipitates and individual submicron AlN precipitates were observed in a modest fraction of the grains. The nano-precipitates were found to be coherent with a well-defined crystallographic relationship to the matrix. The chemistry, size and distribution of both types of precipitates and the coherency of the nano-precipitates indicate that both intragranular homogeneous and heterogeneous precipitation occurred during cooling. (C) 2015 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. C1 [Xie, Kelvin Y.; Hemker, Kevin J.] Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21210 USA. [Livi, Kenneth] Johns Hopkins Univ, Intergrated Image Ctr, Baltimore, MD 21210 USA. [McCauley, James W.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Hemker, KJ (reprint author), Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21210 USA. EM hemker@jhu.edu RI Xie, Kelvin/M-2248-2016 OI Xie, Kelvin/0000-0001-8675-5321 FU Army Research Laboratory [W911NF-12-2-0022] FX This research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-12-2-0022. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 20 TC 3 Z9 3 U1 2 U2 19 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6462 J9 SCRIPTA MATER JI Scr. Mater. PD MAY PY 2015 VL 101 BP 95 EP 98 DI 10.1016/j.scriptamat.2015.02.002 PG 4 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA CD2TV UT WOS:000350932800025 ER PT J AU White, TL Krausman, AS AF White, Timothy L. Krausman, Andrea S. TI Effects of inter-stimulus interval and intensity on the perceived urgency of tactile patterns SO APPLIED ERGONOMICS LA English DT Article DE Tactile; Perceived urgency; Dismounted maneuvers ID INTERRUPTION MANAGEMENT; DISPLAYS; SUPPORT; CUES AB This research examines the feasibility of coding urgency into tactile patterns. Four tactile patterns were presented at either, 12 or 23.5 dB above mean threshold, with an ISI of either 0 (no interval) or 500 msec. Measures included pattern identification and urgency rating on a scale of 1 (least urgent) to 10 (most urgent). Two studies were conducted, a laboratory study and a field study. In the laboratory study, participants received the tactile patterns while seated in front of a computer. For the field study, participants performed dismounted Soldier maneuvers while receiving the tactile patterns. Higher identification rates were found for the 23.5 dB intensity. Patterns presented at the 23.5 dB intensity and no ISI were rated most urgent. No differences in urgency ratings were found for 12 dB based on ISI. Findings support the notion of coding urgency into tactile patterns as a way of augmenting tactile communication. Published by Elsevier Ltd. C1 [White, Timothy L.; Krausman, Andrea S.] US Army, Res Lab, Dismounted Warrior Branch, Aberdeen Proving Ground, MD USA. RP White, TL (reprint author), 4580 Concord Landing Dr,Apt 214, Orlando, FL 32839 USA. EM timothy.l.white1.civ@mail.mil FU United States Army Research Laboratory; United States Army Natick Soldier Research, Development, and Engineering Center FX This research was supported by a Technology Program Agreement between the United States Army Research Laboratory and the United States Army Natick Soldier Research, Development, and Engineering Center. NR 27 TC 2 Z9 2 U1 0 U2 6 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0003-6870 EI 1872-9126 J9 APPL ERGON JI Appl. Ergon. PD MAY PY 2015 VL 48 BP 121 EP 129 DI 10.1016/j.apergo.2014.11.010 PG 9 WC Engineering, Industrial; Ergonomics; Psychology, Applied SC Engineering; Psychology GA CD0QI UT WOS:000350778600014 PM 25683539 ER PT J AU Myles, K Kalb, JT Lowery, J Kattel, BP AF Myles, Kimberly Kalb, Joel T. Lowery, Janea Kattel, Bheem P. TI The effect of hair density on the coupling between the tactor and the skin of the human head SO APPLIED ERGONOMICS LA English DT Article DE Tactile sensitivity; Head tactile display; Vibrotactile detection on scalp ID VIBROTACTILE LOCALIZATION; TACTILE DISPLAYS; THRESHOLD; STIMULATION; PERFORMANCE; PARAMETERS; PERCEPTION; DIRECTION; WARNINGS; THREAT AB The purpose of this study was to determine the effect of hair density on vibration detection thresholds associated with the perception of low frequency vibration stimuli applied to the head. A host of tactile sensitivity information exists for other parts of the body, however the same information is lacking for the head. Thirty-three college students, age 18-35, were recruited for the study. A mixed design was used to evaluate the effect of hair density, head location, and frequency on vibration detection thresholds. Results suggest that hair density might slightly impede vibration signals from reaching the scalp and reduce vibration sensitivity, for the least sensitive locations on the head. This research provides design recommendations for head-mounted tactile displays for women and those with hair that can be used to convey directional cues for navigation and as alerts to critical events in the environment. Published by Elsevier Ltd. C1 [Myles, Kimberly; Kalb, Joel T.] US Army Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. [Lowery, Janea; Kattel, Bheem P.] Morgan State Univ, Dept Ind & Syst Engn, Baltimore, MD 21251 USA. RP Myles, K (reprint author), US Army Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. EM kim.myles@us.army.mil; joel.kalb@us.army.mil; janea.lowery@gmail.com; bheem.kattel@morgan.edu NR 47 TC 1 Z9 1 U1 1 U2 7 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0003-6870 EI 1872-9126 J9 APPL ERGON JI Appl. Ergon. PD MAY PY 2015 VL 48 BP 177 EP 185 DI 10.1016/j.apergo.2014.11.007 PG 9 WC Engineering, Industrial; Ergonomics; Psychology, Applied SC Engineering; Psychology GA CD0QI UT WOS:000350778600020 PM 25683545 ER PT J AU Meredith, CS Khan, AS AF Meredith, Christopher S. Khan, Akhtar S. TI The microstructural evolution and thermo-mechanical behavior of UFG Ti processed via equal channel angular pressing SO JOURNAL OF MATERIALS PROCESSING TECHNOLOGY LA English DT Article DE Equal channel angular pressing (ECAP); Grain refinement; Twinning; Ultrafine grained (UFG) Ti; Kolsky bar; Electron backscatter diffraction (EBSD) ID SEVERE PLASTIC-DEFORMATION; STRAIN-RATE; PURE TI; NANOSTRUCTURED TITANIUM; TEMPERATURE; SLIP; NANOCRYSTALLINE; SENSITIVITY; ANISOTROPY; MAGNESIUM AB Equal channel angular pressing (ECAP) was applied to grade 1 Ti for up to four passes and the microstructure and thermo-mechanical behavior were determined. ECAP was performed with a channel angle of 90 degrees, at a pressing temperature of 275 degrees C, and using route B-c. Electron backscatter diffraction (EBSD) was used to characterize the microstructure. After the first pass of ECAP, {1 0 (1) over bar 1} twins were present, but significant slip had also occurred. The microstructure was highly anisotropic, consisting of relatively undeformed grains to grains less than a micrometer. Increasing the number of passes decreased the grain anisotropy, and by the fourth pass a relatively homogeneous microstructure was present. After all numbers of passes, there was evidence for continuous dynamic recrystallization as the mechanism of grain refinement, even when twinning had occurred. This refinement accelerated as the number of passes increased. The response of UFG Ti was determined at - 196, 22, 200 and 375 degrees C, and at strain rates from 10(-4) to 1100 s(-1). It was found that the ECAP process greatly increases the yield strength versus the as-received condition, and UFG Ti has similar work hardening as the as-received material. The work hardening does not decrease much as the number of passes is increased. Additionally, the strain rate sensitivity tends to increase with the temperature and decrease as the number of passes is increased. (C) 2015 Elsevier B.V. All rights reserved. C1 [Meredith, Christopher S.] Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Khan, Akhtar S.] Univ Maryland Baltimore Cty, Dept Mech Engn, Baltimore, MD 21250 USA. RP Meredith, CS (reprint author), Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM christopher.s.meredith3.ctr@mail.mil OI Meredith, Christopher/0000-0003-1368-8003 FU GAANN fellowship from the Department of Mechanical Engineering at UMBC FX This work was supported by the GAANN fellowship from the Department of Mechanical Engineering at UMBC. The salt used for heating the billets was obtained free of charge from Hubbard-Hall, Inc. Thanks to Brian Schuster and Jonathon Ligda at ARL for the use of and help with EBSD. NR 34 TC 3 Z9 3 U1 5 U2 22 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0924-0136 J9 J MATER PROCESS TECH JI J. Mater. Process. Technol. PD MAY PY 2015 VL 219 BP 257 EP 270 DI 10.1016/j.jmatprotec.2014.12.024 PG 14 WC Engineering, Industrial; Engineering, Manufacturing; Materials Science, Multidisciplinary SC Engineering; Materials Science GA CC7BF UT WOS:000350522000026 ER PT J AU Jones, KA Chow, TP Wraback, M Shatalov, M Sitar, Z Shahedipour, F Udwary, K Tompa, GS AF Jones, K. A. Chow, T. P. Wraback, M. Shatalov, M. Sitar, Z. Shahedipour, F. Udwary, K. Tompa, G. S. TI AlGaN devices and growth of device structures SO JOURNAL OF MATERIALS SCIENCE LA English DT Review ID VAPOR-PHASE EPITAXY; ELECTRON-MOBILITY TRANSISTORS; MOLECULAR-BEAM EPITAXY; FIELD-EFFECT TRANSISTORS; GAN BUFFER LAYERS; MISFIT DISLOCATION FORMATION; REVERSE-BIAS LEAKAGE; QUANTUM-WELL LASER; DOPED GAN; BREAKDOWN VOLTAGE AB The structure of a number of GaN/AlGaN devices and their associated material growth and processing issues are examined in some detail, and extrapolations are made to predict what the advantages and challenges would accrue for similar AlGaN electrical and optical devices. For RF HEMTs, it is likely that the advantages of the larger breakdown voltage (V (B)) in an Al (Y) Ga1-Y N/Al (X) Ga1-X N AlGaN channel HEMT would be outweighed by the disadvantages of the lower frequency of operation created by the smaller channel mobility when compared to AlGaAs/GaAs HEMTs. The same thing can be said for lateral high-power electronic HEMTs because AlGaN/GaN HEMTs with GaN channels can now be fabricated with V (B) similar to 2,000 V, which is thought to be the upper voltage limit for them, even when the device structures are grown on Si substrates with its accompanying high dislocation density and bow. However, theory suggests that using Al (Y) Ga1-Y N/Al (X) Ga1-X N structures in vertical transistors and AlGaN P-N diodes could enable pulsed power applications such as electric armor because they should be able to handle an order of magnitude more power due to their ten times larger breakdown field in similar to 80 % Al AlGaN, and the Si donor is still relatively shallow at this Al concentration. The major challenges to achieving these goals are to be able to controllably dope the AlGaN in the mid 10(15) cm(-3) range, create an AlGaN current blocking layer beneath the Al (Y) Ga1-Y N/Al (X) Ga1-X N channel that contains an aperture to the drain, confine most of the mismatch dislocations in the AlGaN layers to near the interface with the GaN or AlN substrate that is parallel to the (0001) plane, and fabricate ohmic contacts to the AlGaN with a specific contact resistance < 10(-2) a"broken vertical bar cm(2). Theoretically, the latter can be achieved using polarization doping. For applications to optical device structures, reducing the threading dislocation density in AlN layers on sapphire substrates by high temperature epitaxy is a key parameter for achieving AlGaN-based light emitters with a high efficiency. Stress control and prevention of relaxation is important for obtaining AlGaN layers with a similar dislocation density as the underlying AlN template. A dislocation density below 5 x 10(8) cm(-2) is sufficient for obtaining an efficiency of radiative recombination of 40 % and higher at moderate excitation levels. C1 [Jones, K. A.; Wraback, M.] Army Res Lab SEDD, Adelphi, MD 20783 USA. [Chow, T. P.] Rensselaer Polytech Inst, Elect Comp & Syst Engn Dept, Troy, NY 12180 USA. [Shatalov, M.] Sensor Elect Technol Inc, Columbia, SC 29209 USA. [Sitar, Z.] N Carolina State Univ, Mat Sci & Engn Dept, Raleigh, NC 27695 USA. [Shahedipour, F.] SUNY Albany, Coll Nanoscale Sci & Engn, Albany, NY 12222 USA. [Udwary, K.] Kyma Technol Inc, Raleigh, NC 27617 USA. [Tompa, G. S.] Struct Mat Ind Inc, Piscataway, NJ USA. RP Jones, KA (reprint author), Army Res Lab SEDD, Adelphi, MD 20783 USA. EM kenneth.a.jones162.civ@mail.mil NR 219 TC 6 Z9 6 U1 33 U2 242 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0022-2461 EI 1573-4803 J9 J MATER SCI JI J. Mater. Sci. PD MAY PY 2015 VL 50 IS 9 BP 3267 EP 3307 DI 10.1007/s10853-015-8878-3 PG 41 WC Materials Science, Multidisciplinary SC Materials Science GA CC7SV UT WOS:000350569600001 ER PT J AU Amaya, M Keck, F Lindquist, M Voss, K Scavone, L Kehn-Hall, K Roberts, B Bailey, C Schmaljohn, C Narayanan, A AF Amaya, Moushimi Keck, Forrest Lindquist, Michael Voss, Kelsey Scavone, Lauren Kehn-Hall, Kylene Roberts, Brian Bailey, Charles Schmaljohn, Connie Narayanan, Aarthi TI The Ubiquitin Proteasome System Plays a Role in Venezuelan Equine Encephalitis Virus Infection SO PLOS ONE LA English DT Article ID ACUTE RESPIRATORY SYNDROME; ATTENUATED VACCINE; MULTIPLE-MYELOMA; CAPSID PROTEIN; OLD-WORLD; INHIBITION; REPLICATION; ALPHAVIRUSES; BORTEZOMIB; CELLS AB Many viruses have been implicated in utilizing or modulating the Ubiquitin Proteasome System (UPS) to enhance viral multiplication and/or to sustain a persistent infection. The mosquito-borne Venezuelan equine encephalitis virus (VEEV) belongs to the Togaviridae family and is an important biodefense pathogen and select agent. There are currently no approved vaccines or therapies for VEEV infections; therefore, it is imperative to identify novel targets for therapeutic development. We hypothesized that a functional UPS is required for efficient VEEV multiplication. We have shown that at non-toxic concentrations Bortezomib, a FDA-approved inhibitor of the proteasome, proved to be a potent inhibitor of VEEV multiplication in the human astrocytoma cell line U87MG. Bortezomib inhibited the virulent Trinidad donkey (TrD) strain and the attenuated TC-83 strain of VEEV. Additional studies with virulent strains of Eastern equine encephalitis virus (EEEV) and Western equine encephalitis virus (WEEV) demonstrated that Bortezomib is a broad spectrum inhibitor of the New World alphaviruses. Time-of-addition assays showed that Bortezomib was an effective inhibitor of viral multiplication even when the drug was introduced many hours post exposure to the virus. Mass spectrometry analyses indicated that the VEEV capsid protein is ubiquitinated in infected cells, which was validated by confocal microscopy and immunoprecipitation assays. Subsequent studies revealed that capsid is ubiquitinated on K48 during early stages of infection which was affected by Bortezomib treatment. This study will aid future investigations in identifying host proteins as potential broad spectrum therapeutic targets for treating alphavirus infections. C1 [Amaya, Moushimi; Keck, Forrest; Voss, Kelsey; Scavone, Lauren; Kehn-Hall, Kylene; Bailey, Charles; Narayanan, Aarthi] George Mason Univ, Sch Syst Biol, Natl Ctr Biodefense & Infect Dis, Manassas, VA 20110 USA. [Lindquist, Michael; Schmaljohn, Connie] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Roberts, Brian] Leidos Hlth Life Sci, Frederick, MD USA. RP Narayanan, A (reprint author), George Mason Univ, Sch Syst Biol, Natl Ctr Biodefense & Infect Dis, Manassas, VA 20110 USA. EM anaraya1@gmu.edu FU George Mason University FX This work was supported by George Mason University start up funds to AN. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 43 TC 3 Z9 3 U1 1 U2 7 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD APR 30 PY 2015 VL 10 IS 4 AR e0124792 DI 10.1371/journal.pone.0124792 PG 24 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CH0MA UT WOS:000353713100049 PM 25927990 ER PT J AU Killops, KL Brucks, SD Rutkowski, KL Freyer, JL Jiang, YV Valdes, ER Campos, LM AF Killops, Kato L. Brucks, Spencer D. Rutkowski, Kourtney L. Freyer, Jessica L. Jiang, Yivan Valdes, Erica R. Campos, Luis M. TI Synthesis of Robust Surface-Charged Nanoparticles Based on Cyclopropenium Ions SO MACROMOLECULES LA English DT Article ID POTENT DELIVERY-SYSTEM; EMULSION POLYMERIZATION; BLOCK-COPOLYMERS; LATEX-PARTICLES; CHIRAL CYCLOPROPENIMINES; AMPHIPHILIC BLOCK; CELLULAR UPTAKE; STYRENE; DESIGN; SIRNA AB We investigate synthetic strategies of cationic slit-face-charged nanoparticles using cyclopropenium-based (CP) monomers and block copolyelectrolytes (BCPEs) via surfactant-free emulsion polymerization. The monomers and BCPEs themselves were found to stabilize oil-in-water emulsions. With these systems, the hydrodynamic diameters of the resultant particles can be reliably tuned from 30 to 100 nm, simply by varying the amount of CP monomer added. As CP is a remarkably stable carbocation, the nanoparticles retain their charge over a Wide pH range. Furthermore, we found that the nanoparticle interior can be covalently functionalized with fluorescent dyes. The ability to easily synthesize sub-100 nm surface-charged particles with narrow polydispersity in one-pot can lead to applications as additives, gene-delivery vectors, and chromatographic separation, among others. Here, we demonstrate the versatility of,CP-based monomers and BCPEs for the synthesis of surface- charged nanoparticles and the modulation of synthetic parameters to tune nanoparticle size and surface functionality. C1 [Killops, Kato L.; Valdes, Erica R.] US Army Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. [Brucks, Spencer D.; Freyer, Jessica L.; Jiang, Yivan; Campos, Luis M.] Columbia Univ, Dept Chem, New York, NY 10027 USA. [Rutkowski, Kourtney L.] Oak Ridge Inst Sci & Educ, Oak Ridge, TN 37831 USA. RP Campos, LM (reprint author), Columbia Univ, Dept Chem, New York, NY 10027 USA. EM lcampos@columbia.edu FU Army Research Office [W911NF-14-0137]; National Science Foundation (CAREER) [DMR-1351293]; ACS Petroleum Research Fund [54471-DNI7]; 3M Non-Tenured Faculty Award FX This work was supported in part by the Army Research Office (W911NF-14-0137), National Science Foundation (CAREER, DMR-1351293), ACS Petroleum Research Fund (54471-DNI7), and 3M Non-Tenured Faculty Award. K.L.K. thanks the Department of the Army Basic Research Program and the Edgewood Chemical Biological Center. K.L.R. thanks the Minority Undergraduate Summer Internship Program (MUSIP) for the opportunity to conduct research at ECBC. Y.J. thanks the Columbia Amgen Scholars Program and the Columbia Science Research Fellows. NR 45 TC 4 Z9 4 U1 2 U2 15 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0024-9297 EI 1520-5835 J9 MACROMOLECULES JI Macromolecules PD APR 28 PY 2015 VL 48 IS 8 BP 2519 EP 2525 DI 10.1021/acs.macromol.5b00403 PG 7 WC Polymer Science SC Polymer Science GA CH2OP UT WOS:000353864800021 ER EF