FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Pavliscsak, H Little, JR Poropatich, RK McVeigh, FL Tong, J Tillman, JS Smith, CH Fonda, SJ AF Pavliscsak, Holly Little, Jeanette R. Poropatich, Ronald K. McVeigh, Francis L. Tong, James Tillman, Johnie S. Smith, Challis H. Fonda, Stephanie Jo TI Assessment of patient engagement with a mobile application among service members in transition SO JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION LA English DT Article DE case management; traumatic brain injury; post-traumatic stress disorder; mobile health; patient engagement ID MANAGEMENT; PROGRAM; INTERVENTIONS; EMPOWERMENT; OUTCOMES; PHONES; MODEL; CARE AB Objective: This article examines engagement with a mobile application ("mCare") for wounded Service Members rehabilitating in their communities. Many had behavioral health problems, Traumatic Brain Injury (TBI), and/or post-traumatic stress disorder (PTS). The article also examines associations between Service Members' background characteristics and their engagement with mCare. Materials and Methods: This analysis included participants who received mCare (n = 95) in a randomized controlled trial. mCare participants received status questionnaires daily for up to 36 weeks. Participant engagement encompasses exposure to mCare, percentage of questionnaires responded to, and response time. Participants were grouped by health status-that is, presence/absence of behavioral health problems, PTS, and/or TBI. Histograms and regression analyses examined engagement by participants' health status and background characteristics. Results: Exposure to mCare did not differ by health status. Participants usually responded to >= 60% of the questionnaires weekly, generally in <= 10 h; however, participants with behavioral health problems had several weeks with <50% response and the longest response times. Total questionnaires responded to and response time did not differ statistically by health status. Older age and higher General Well-Being Schedule scores were associated with greater and faster response. Discussion: The sustained response to the questionnaires suggests engagement. Overall level of response surpassed trends reported for American's usage of mobile applications. With a few exceptions, Service Members engaged with mCare irrespective of health status. Conclusion: Mobile health has the potential to increase the quantity and quality of patient-provider communications in a community-based, rehabilitation care setting, above that of standard care. C1 [Pavliscsak, Holly] USAMRMC, TATRC, Mobile Hlth Care Innovat Ctr MHIC, Geneva Fdn, Ft Gordon, GA 30905 USA. [Little, Jeanette R.] US Army, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Mobile Hlth Innovat Ctr, Ft Gordon, GA 30905 USA. [Poropatich, Ronald K.] Univ Pittsburgh, Ctr Mil Med Res, Pittsburgh, PA USA. [McVeigh, Francis L.] US Army, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Adv Technol & Innovat Lab, Ft Detrick, MD USA. [Tong, James] Govt Solut, IMS Hlth, Washington, DC USA. [Tillman, Johnie S.] Integrated Disabil Evaluat Syst, Ft Gordon, GA USA. [Smith, Challis H.] Virginia Dept Behav Hlth & Dev Serv, Qual Management & Dev, Richmond, VA USA. [Fonda, Stephanie Jo] Walter Reed Natl Mil Med Ctr, Geneva Res Fdn, Dept Endocrinol, Bethesda, MD USA. RP Pavliscsak, H (reprint author), USAMRMC, TATRC, Mobile Hlth Care Innovat Ctr MHIC, Geneva Fdn, Ft Gordon, GA 30905 USA. EM holly.h.pavliscsak.ctr@mail.mil; jeanette.r.little.civ@mail.mil; rkp19@pitt.edu; francis.l.mcveigh.civ@mail.mil; jtong@us.imshealth.com; johnie.s.tillman.civ@mail.mil; chc.smith@us.army.mil; sfonda@genevausa.org RI Emchi, Karma/Q-1952-2016 FU Office of Force Health Protection FX This study was funded by the Office of Force Health Protection, and managed by the Mobile Health Innovation Center, an intramural laboratory of the Telemedicine and Advanced Technology Research Center, United States Army Medical Research and Material Command. NR 29 TC 2 Z9 2 U1 1 U2 2 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1067-5027 EI 1527-974X J9 J AM MED INFORM ASSN JI J. Am. Med. Inf. Assoc. PD JAN PY 2016 VL 23 IS 1 BP 110 EP 118 DI 10.1093/jamia/ocv121 PG 9 WC Computer Science, Information Systems; Computer Science, Interdisciplinary Applications; Health Care Sciences & Services; Information Science & Library Science; Medical Informatics SC Computer Science; Health Care Sciences & Services; Information Science & Library Science; Medical Informatics GA DJ4MK UT WOS:000374179500015 PM 26363048 ER PT J AU Champagne, VK West, MK Rokni, MR Curtis, T Champagne, V McNally, B AF Champagne, Victor Kenneth, III West, Michael K. Rokni, M. Reza Curtis, Todd Champagne, Victor, Jr. McNally, Baillie TI Joining of Cast ZE41A Mg to Wrought 6061 Al by the Cold Spray Process and Friction Stir Welding SO JOURNAL OF THERMAL SPRAY TECHNOLOGY LA English DT Article; Proceedings Paper CT International Thermal Spray Conference CY MAY 11-14, 2015 CL Long Beach, CA SP ASM Int Thermal Spray Soc, German Welding Soc, Int Inst Welding DE cold spray; electron microscopy; mechanical properties; microhardness; microstructure; optical microscopy; tensile bond strength ID ALUMINUM-ALLOY; MAGNESIUM ALLOYS; MICROSTRUCTURE; PARTICLES; INTERFACE; COATINGS AB This paper presents a novel method for joining cast ZE41A-T5 Mg to wrought 6061-T6 Al, without forming deleterious, coarse intermetallic compounds, which is not currently possible with conventional technologies. The novel aspect of the process includes the development of a joint design using cold spray (CS) as the enabling technology, to produce a transitional layer onto which a conventional welding technique can be employed to join the two dissimilar materials. The emphasis in this study will be on the CS transitional layer (T-layer) which enables the joining of cast ZE41A-T5 magnesium (Mg) and wrought 6061-T6 aluminum (Al) by friction-stir welding and the subsequent materials characterization to show the structural integrity of the entire joint. In order to join Mg and Al plates by this method, a transitional layer of CS Al is first deposited along the edge of cast ZE41A Mg plate. The CS Al T-layer enables the Mg to be friction stir welded to a plate of wrought 6061 Al, thereby completing the Mg plate to Al plate joint. Friction stir welding was chosen in this study to join the CS Al T-layer to the wrought Al plate; however, other conventional welding techniques could also be employed for joining Mg to Al in this manner. The CS Al T-layer is compatible to the wrought 6061 Al plate and serves as an insulating layer that prevents heat generated during the friction stir welding process from extending into the magnesium, thus preventing the formation of intermetallics. In this study, two sets of samples were produced joining cast ZE41A-T5 magnesium (Mg) and wrought 6061-T6 aluminum: one set using CS 6061 Al as the transition material between the ZE41A Mg plate and 6061 Al plate and the other set using CS 5056 Al as the transition material. Microstructural analysis by scanning and transmission electron microscopy and optical microscopy, along with mechanical test results including triple lug shear, tension, and micro hardness will be presented. Comparisons will be made to conventional joining techniques and the importance, as well as the applications of this technique, will be discussed. C1 [Champagne, Victor Kenneth, III] Univ Massachusetts, Amherst, MA 01003 USA. [West, Michael K.; Rokni, M. Reza; Curtis, Todd] South Dakota Sch Mines & Technol, Rapid City, SD USA. [Champagne, Victor, Jr.] US Army Res Lab, Aberdeen, MD USA. [McNally, Baillie] Worcester Polytech Inst, Worcester, MA 01609 USA. RP Champagne, V (reprint author), US Army Res Lab, Aberdeen, MD USA. EM vchampagne@umass.edu NR 42 TC 1 Z9 1 U1 9 U2 18 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1059-9630 EI 1544-1016 J9 J THERM SPRAY TECHN JI J. Therm. Spray Technol. PD JAN PY 2016 VL 25 IS 1-2 BP 143 EP 159 DI 10.1007/s11666-015-0301-8 PG 17 WC Materials Science, Coatings & Films SC Materials Science GA DJ5RP UT WOS:000374268000016 ER PT J AU Widener, CA Carter, MJ Ozdemir, OC Hrabe, RH Hoiland, B Stamey, TE Champagne, VK Eden, TJ AF Widener, C. A. Carter, M. J. Ozdemir, O. C. Hrabe, R. H. Hoiland, B. Stamey, T. E. Champagne, V. K. Eden, T. J. TI Application of High-Pressure Cold Spray for an Internal Bore Repair of a Navy Valve Actuator SO JOURNAL OF THERMAL SPRAY TECHNOLOGY LA English DT Article; Proceedings Paper CT International Thermal Spray Conference CY MAY 11-14, 2015 CL Long Beach, CA SP ASM Int Thermal Spray Soc, German Welding Soc, Int Inst Welding DE cold spray; corrosion; marine components; repair; tensile bond strength ID DEPOSITION AB Cold spray is a reduced temperature, supersonic thermal spray process that is increasingly being used to perform repairs on high-value components. In this case, a valve actuator internal bore sealing surface was repaired on an aluminum 6061 hydraulic valve body using high-pressure cold spray. Corrosion damage to non-critical surfaces was also repaired, allowing the part to be returned to service. A high-pressure cold spray system was used to deposit gas-atomized 6061 aluminum powder using helium. The internal bore surfaces were approximately 100 mm in diameter with a depth of nearly 200 mm, and were sprayed using a 45 degrees nozzle 65 mm in length. Modeling predictions validated the approach, and were used to identify a favorable nozzle geometry and process window combination. The minimum required adhesion strength on critical surfaces was 69 MPa. The average adhesion strength was 71.4 MPa, with glue failures on ASTM C633 bond test specimens. The actuator subsequently passed all bench top service related testing, was qualified as an approved repair, and is now in service. This was a first of its kind repair for cold spray, and demonstrates that it is a viable repair technology and is ready for broader implementation. C1 [Widener, C. A.; Carter, M. J.; Ozdemir, O. C.] South Dakota Sch Mines & Technol, Rapid City, SD 57701 USA. [Hrabe, R. H.] VRC Met Syst, Rapid City, SD USA. [Hoiland, B.] MOOG Mid Amer Aviat, West Fargo, ND USA. [Stamey, T. E.] Puget Sound Naval Shipyard, Bremerton, WA USA. [Champagne, V. K.] Army Res Lab, Aberdeen Proving Ground, MD USA. [Eden, T. J.] Penn State Appl Res Lab, State Coll, PA USA. RP Widener, CA (reprint author), South Dakota Sch Mines & Technol, Rapid City, SD 57701 USA. EM Christian.Widener@sdsmt.edu NR 14 TC 2 Z9 2 U1 2 U2 8 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1059-9630 EI 1544-1016 J9 J THERM SPRAY TECHN JI J. Therm. Spray Technol. PD JAN PY 2016 VL 25 IS 1-2 BP 193 EP 201 DI 10.1007/s11666-015-0366-4 PG 9 WC Materials Science, Coatings & Films SC Materials Science GA DJ5RP UT WOS:000374268000020 ER PT J AU Abid, I Bohloul, A Najmaei, S Avendano, C Liu, HL Pechou, R Mlayah, A Lou, J AF Abid, I. Bohloul, A. Najmaei, S. Avendano, C. Liu, H. -L. Pechou, R. Mlayah, A. Lou, J. TI Resonant surface plasmon-exciton interaction in hybrid MoSe2@Au nanostructures SO NANOSCALE LA English DT Article ID TRANSITION-METAL DICHALCOGENIDES; DISCRETE-DIPOLE APPROXIMATION; DISULFIDE ATOMIC LAYERS; MONOLAYER MOS2; ELECTRONIC-STRUCTURE; VALLEY POLARIZATION; QUANTUM-DOT; PHOTOLUMINESCENCE; SEMICONDUCTORS; NANOANTENNA AB In this work we investigate the interaction between plasmonic and excitonic resonances in hybrid MoSe2@Au nanostructures. The latter were fabricated by combining chemical vapor deposition of MoSe2 atomic layers, Au disk processing by nanosphere lithography and a soft lift-off/transfer technique. The samples were characterized by scanning electron and atomic force microscopy. Their optical properties were investigated experimentally using optical absorption, Raman scattering and photoluminescence spectroscopy. The work is focused on a resonant situation where the surface plasmon resonance is tuned to the excitonic transition. In that case, the near-field interaction between the surface plasmons and the confined excitons leads to interference between the plasmonic and excitonic resonances that manifests in the optical spectra as a transparency dip. The plasmonic-excitonic interaction regime is determined using quantitative analysis of the optical extinction spectra based on an analytical model supported by numerical simulations. We found that the plasmonic-excitonic resonances do interfere thus leading to a typical Fano lineshape of the optical extinction. The near-field nature of the plasmonic-excitonic interaction is pointed out experimentally from the dependence of the optical absorption on the number of monolayer stacks on the Au nanodisks. The results presented in this work contribute to the development of new concepts in the field of hybrid plasmonics. C1 [Abid, I.; Pechou, R.; Mlayah, A.] Univ Toulouse, CNRS, UPR 8011, Ctr Elaborat Mat & Etud Struct, 29 Rue Jeanne Marvig,BP 94347, F-31055 Toulouse, France. [Bohloul, A.; Najmaei, S.; Avendano, C.; Lou, J.] Rice Univ, Dept Mat Sci & NanoEngn, Houston, TX 77005 USA. [Najmaei, S.] Sensors & Electron Devices Directorate, US Army Res Labs, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Liu, H. -L.] Natl Taiwan Normal Univ, Dept Phys, Taipei 11677, Taiwan. RP Mlayah, A (reprint author), Univ Toulouse, CNRS, UPR 8011, Ctr Elaborat Mat & Etud Struct, 29 Rue Jeanne Marvig,BP 94347, F-31055 Toulouse, France.; Lou, J (reprint author), Rice Univ, Dept Mat Sci & NanoEngn, Houston, TX 77005 USA. EM adnen.mlayah@cemes.fr; jlou@rice.edu FU HPC center CALMIP at the Paul Sabatier University of Toulouse; Labex-NEXT "PLEXMOS" grant; LabEx NEXT under the "incoming PhD" mobility program; Welch Foundation [C-1716]; NSF [ECCS-1327093]; AFOSR [FA9550-14-1-0268]; Ministry of Science and Technology of Republic of China [NSC 102-2112-M-003-002-MY3] FX This work was supported by the HPC center CALMIP at the Paul Sabatier University of Toulouse and by the Labex-NEXT "PLEXMOS" grant. Also S. N. thanks LabEx NEXT for financial support under the "incoming PhD" mobility program. S. N. and J. L. also thank the support of the Welch Foundation grant C-1716, the NSF grant ECCS-1327093 and the AFOSR grant FA9550-14-1-0268. H. L. L. thanks financial support from the Ministry of Science and Technology of Republic of China under grant no. NSC 102-2112-M-003-002-MY3. NR 51 TC 4 Z9 4 U1 32 U2 64 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2040-3364 EI 2040-3372 J9 NANOSCALE JI Nanoscale PY 2016 VL 8 IS 15 BP 8151 EP 8159 DI 10.1039/c6nr00829a PG 9 WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA DJ4FA UT WOS:000374159600042 PM 27029770 ER PT J AU Wahl-Jensen, V Johnson, JC Lauck, M Weinfurter, JT Moncla, LH Weiler, AM Charlier, O Rojas, O Byrum, R Ragland, DR Huzella, L Zommer, E Cohen, M Bernbaum, JG Cai, YY Sanford, HB Mazur, S Johnson, RF Qin, J Palacios, GF Bailey, AL Jahrling, PB Goldberg, TL O'Connor, DH Friedrich, TC Kuhn, JH AF Wahl-Jensen, Victoria Johnson, Joshua C. Lauck, Michael Weinfurter, Jason T. Moncla, Louise H. Weiler, Andrea M. Charlier, Olivia Rojas, Oscar Byrum, Russell Ragland, Dan R. Huzella, Louis Zommer, Erika Cohen, Melanie Bernbaum, John G. Cai, Yingyun Sanford, Hannah B. Mazur, Steven Johnson, Reed F. Qin, Jing Palacios, Gustavo F. Bailey, Adam L. Jahrling, Peter B. Goldberg, Tony L. O'Connor, David H. Friedrich, Thomas C. Kuhn, Jens H. TI Divergent Simian Arteriviruses Cause Simian Hemorrhagic Fever of Differing Severities in Macaques SO MBIO LA English DT Article ID ENDOPLASMIC-RETICULUM; HAEMORRHAGIC FEVER; VIRUS; PATHOLOGY; OUTBREAK; DISEASE; AGENT AB Simian hemorrhagic fever (SHF) is a highly lethal disease in captive macaques. Three distinct arteriviruses are known etiological agents of past SHF epizootics, but only one, simian hemorrhagic fever virus (SHFV), has been isolated in cell culture. The natural reservoir(s) of the three viruses have yet to be identified, but African nonhuman primates are suspected. Eleven additional divergent simian arteriviruses have been detected recently in diverse and apparently healthy African cercopithecid monkeys. Here, we report the successful isolation in MARC-145 cell culture of one of these viruses, Kibale red colobus virus 1 (KRCV-1), from serum of a naturally infected red colobus (Procolobus [Piliocolobus] rufomitratus tephrosceles) sampled in Kibale National Park, Uganda. Intramuscular (i.m.) injection of KRCV-1 into four cynomolgus macaques (Macaca fascicularis) resulted in a self-limiting nonlethal disease characterized by depressive behavioral changes, disturbance in coagulation parameters, and liver enzyme elevations. In contrast, i.m. injection of SHFV resulted in typical lethal SHF characterized by mild fever, lethargy, lymphoid depletion, lymphoid and hepatocellular necrosis, low platelet counts, increased liver enzyme concentrations, coagulation abnormalities, and increasing viral loads. As hypothesized based on the genetic and presumed antigenic distance between KRCV-1 and SHFV, all four macaques that had survived KRCV-1 injection died of SHF after subsequent SHFV injection, indicating a lack of protective heterotypic immunity. Our data indicate that SHF is a disease of macaques that in all likelihood can be caused by a number of distinct simian arteriviruses, although with different severity depending on the specific arterivirus involved. Consequently, we recommend that current screening procedures for SHFV in primate-holding facilities be modified to detect all known simian arteriviruses. IMPORTANCE Outbreaks of simian hemorrhagic fever (SHF) have devastated captive Asian macaque colonies in the past. SHF is caused by at least three viruses of the family Arteriviridae: simian hemorrhagic fever virus (SHFV), simian hemorrhagic encephalitis virus (SHEV), and Pebjah virus (PBJV). Nine additional distant relatives of these three viruses were recently discovered in apparently healthy African nonhuman primates. We hypothesized that all simian arteriviruses are potential causes of SHF. To test this hypothesis, we inoculated cynomolgus macaques with a highly divergent simian arterivirus (Kibale red colobus virus 1 [KRCV-1]) from a wild Ugandan red colobus. Despite being only distantly related to red colobuses, all of the macaques developed disease. In contrast to SHFV-infected animals, KRCV-1-infected animals survived after a mild disease presentation. Our study advances the understanding of an important primate disease. Furthermore, our data indicate a need to include the full diversity of simian arteriviruses in nonhuman primate SHF screening assays. C1 [Wahl-Jensen, Victoria; Johnson, Joshua C.; Rojas, Oscar; Byrum, Russell; Ragland, Dan R.; Huzella, Louis; Zommer, Erika; Cohen, Melanie; Bernbaum, John G.; Cai, Yingyun; Sanford, Hannah B.; Mazur, Steven; Jahrling, Peter B.; Kuhn, Jens H.] NIAID, NIH, Integrated Res Facil Ft Detrick, Frederick, MD USA. [Lauck, Michael; Weinfurter, Jason T.; Moncla, Louise H.; Weiler, Andrea M.; Charlier, Olivia; Bailey, Adam L.; Goldberg, Tony L.; O'Connor, David H.; Friedrich, Thomas C.] Univ Wisconsin, Madison, WI USA. [Johnson, Reed F.; Jahrling, Peter B.] NIAID, NIH, Emerging Viral Pathogens Sect, Frederick, MD USA. [Qin, Jing] NIAID, NIH, Biostat Res Branch, Rockville, MD USA. [Palacios, Gustavo F.] US Army, Med Res Inst Infect Dis, Frederick, MD USA. RP Kuhn, JH (reprint author), NIAID, NIH, Integrated Res Facil Ft Detrick, Frederick, MD USA. EM kuhnjens@mail.nih.gov OI Palacios, Gustavo/0000-0001-5062-1938; Friedrich, Thomas/0000-0001-9831-6895 FU Battelle Memorial Institute; US National Institute of Allergy and Infectious Diseases (NIAID) [HHSN272200700016I]; NIAID Division of Intramural Research; Wisconsin National Primate Research Center Base Grant from the National Center for Research Resources [P51 RR000167]; Office of Research Infrastructure Programs of the National Institutes of Health (NIH) [P51 OD011106]; NIH [R01AI116382]; NIH as part of the joint NIH-NSF Ecology of Infectious Disease program [R01 AI077376]; Office of Research Infrastructure Programs (ORIP) [P51OD011106]; National Research Service Award (NRSA) through Microbes in Health and Disease (MHD) training program at the University of Wisconsin [T32 AI55397]; University of Wisconsin's Medical Scientist Training Program (MSTP) [T32 GM008692] FX This work was funded in part through Battelle Memorial Institute's prime contract with the US National Institute of Allergy and Infectious Diseases (NIAID) under Contract No. HHSN272200700016I. J.C.J. performed this work as an employee of Battelle Memorial Institute. Subcontractors to Battelle Memorial Institute who performed this work are: O.R., R.B., D.R.R., L.H., employees of Charles River Laboratories; V.W-J., J.G.B, Y.C., H.B.S., and J.H.K, employees of Tunnell Government Services, Inc.; M.C., an employee of Lovelace Respiratory Research Institute; and E.Z. and S.M., employees of MRIGlobal Research Institute. This study was also funded, in part, by the NIAID Division of Intramural Research (R.F.J., P.B.J.). The work of M.L., J.T.W., L.H.M., A.M.W., O.C., A.L.B., T.L.G., D.H.O'C., and T.C.F. was supported in part by the Wisconsin National Primate Research Center Base Grant from the National Center for Research Resources (P51 RR000167) and the Office of Research Infrastructure Programs (P51 OD011106) of the National Institutes of Health (NIH); NIH grant R01AI116382; NIH grant TW009237 as part of the joint NIH-NSF Ecology of Infectious Disease program, grant R01 AI077376; and by the Office of Research Infrastructure Programs (ORIP) grant P51OD011106. A.L.B. was additionally supported via a National Research Service Award (NRSA) through the Microbes in Health and Disease (MHD) training program at the University of Wisconsin (T32 AI55397) and University of Wisconsin's Medical Scientist Training Program (MSTP) grant T32 GM008692. NR 30 TC 2 Z9 2 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 2150-7511 J9 MBIO JI mBio PD JAN-FEB PY 2016 VL 7 IS 1 AR e02009-15 DI 10.1128/mBio.02009-15 PG 10 WC Microbiology SC Microbiology GA DJ0ZO UT WOS:000373933100065 PM 26908578 ER PT J AU Nafari, RH Ngo, T Lehman, W AF Nafari, R. Hasanzadeh Ngo, T. Lehman, W. TI Calibration and validation of FLFA(rs) - a new flood loss function for Australian residential structures SO NATURAL HAZARDS AND EARTH SYSTEM SCIENCES LA English DT Article ID DAMAGE ESTIMATION; COMMERCIAL SECTOR; BUILDINGS; MODEL; FLEMOCS; CURVES; AREAS AB Rapid urbanisation, climate change and unsustainable developments are increasing the risk of floods. Flood is a frequent natural hazard that has significant financial consequences for Australia. The emergency response system in Australia is very successful and has saved many lives over the years. However, the preparedness for natural disaster impacts in terms of loss reduction and damage mitigation has been less successful. In this paper, a newly derived flood loss function for Australian residential structures (FLFA(rs)) has been presented and calibrated by using historic data collected from an extreme event in Queensland, Australia, that occurred in 2013. Afterwards, the performance of the method developed in this work (contrasted to one Australian model and one model from USA) has been compared with the observed damage data collected from a 2012 flood event in Maranoa, Queensland. Based on this analysis, validation of the selected methodologies has been performed in terms of Australian geographical conditions. Results obtained from the new empirically based function (FLFA(rs)) and the other models indicate that it is apparent that the precision of flood damage models is strongly dependent on selected stage damage curves, and flood damage estimation without model calibration might result in inaccurate predictions of losses. Therefore, it is very important to be aware of the associated uncertainties in flood risk assessment, especially if models have not been calibrated with real damage data. C1 [Nafari, R. Hasanzadeh] Univ Melbourne, Dept Infrastruct Engn, CDMPS, Melbourne, Vic, Australia. [Ngo, T.] Univ Melbourne, Dept Infrastruct Engn, Adv Protect Technol Engn Struct APTES Grp, Melbourne, Vic, Australia. [Lehman, W.] USACE, Inst Water Resources, HEC, Davis, CA USA. RP Nafari, RH (reprint author), Univ Melbourne, Dept Infrastruct Engn, CDMPS, Melbourne, Vic, Australia. EM rhasanzadeh@student.unimelb.edu.au RI Hasanzadeh Nafari, Roozbeh/N-3934-2015 OI Hasanzadeh Nafari, Roozbeh/0000-0002-3987-4974 FU Bushfire and Natural Hazards CRC FX We would like to thank the Queensland Reconstruction Authority for their kind support and for providing us with invaluable resources and data sets. Also, the authors would like to acknowledge the ongoing financial contribution and support from the Bushfire and Natural Hazards CRC. NR 55 TC 2 Z9 2 U1 1 U2 3 PU COPERNICUS GESELLSCHAFT MBH PI GOTTINGEN PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY SN 1561-8633 J9 NAT HAZARD EARTH SYS JI Nat. Hazards Earth Syst. Sci. PY 2016 VL 16 IS 1 BP 15 EP 27 DI 10.5194/nhess-16-15-2016 PG 13 WC Geosciences, Multidisciplinary; Meteorology & Atmospheric Sciences; Water Resources SC Geology; Meteorology & Atmospheric Sciences; Water Resources GA DJ0TC UT WOS:000373916300002 ER PT B AU Bravo, L Xue, QL Som, S Powell, C Kweon, CBM AF Bravo, Luis Xue, Qingluan Som, Sibendu Powell, Christopher Kweon, Chol-Bum M. GP ASME TI FUEL EFFECTS ON NOZZLE FLOW AND SPRAY USING FULLY COUPLED EULERIAN SIMULATIONS SO PROCEEDINGS OF THE ASME POWER CONFERENCE, 2015 LA English DT Proceedings Paper CT ASME 2015 Power Conference, POWER2015 CY JUN 28-JUL 02, 2015 CL San Diego, CA SP ASME, Power Div ID X-RAY RADIOGRAPHY; SURROGATE MIXTURES; COMBUSTION; MODEL; JP-8; COMPONENTS AB The objective of this study is to examine the impact of single and multi-component surrogate fuel mixtures on the atomization and mixing characteristics of non-reacting isothermal diesel engine sprays. An Eulerian modeling approach was adopted to simulate both the internal nozzle flow dynamics and the emerging turbulent spray in the near nozzle region in a fully-coupled manner. The Volume of Fluids (VoF) methodology was utilized to treat the two-phase flow dynamics including a Homogenous Relaxation approach to account for nozzle cavitation effects. To enable accurate simulations, the nozzle geometry and in-situ multi-dimensional needle lift and off-axis motion profiles have been characterized via the X-ray phase-contrast technique at Argonne National Laboratory. The flow turbulence is treated via the classical k - epsilon Reynolds Average Navier Stoke (RANS) model with in-nozzle and near field resolution of 30 mu m. Several multi-component surrogate mixtures were implemented using linear blending rules to examine the behavior of petroleum, and alternative fuels including: JP -8, JP-5, Hydro-treated Renewable Jet (HRJ), Iso-Paraffinic Kerosene (IPK) with comparison to single component n-dodecane fuel on ECN Spray A nozzle spray dynamics. The results were validated using transient rate-of injection measurements from the Army Research Laboratory at Spray A conditions as well as projected density fields obtained from the line-of-sight measurements from X-ray radiography measurements at The Advanced Photon Source at Argonne National Laboratory. The conditions correspond to injection pressure, nominal fuel temperature, and ambient density of 1500 bar, 363 K, and 22.8 kg/m(3), respectively. The simulation results provide a unique high-fidelity contribution to the effects of fuels on the spray mixing dynamics. The results can lead to improvements in fuel mixture distributions enhancing performance of military vehicles. C1 [Bravo, Luis; Kweon, Chol-Bum M.] US Army Res Lab, Aberdeen Proving Ground, MD USA. [Xue, Qingluan; Som, Sibendu; Powell, Christopher] Argonne Natl Lab, 9700 S Cass Ave, Argonne, IL 60439 USA. RP Bravo, L (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD USA. NR 21 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-5660-4 PY 2016 AR V001T03A012 PG 11 WC Energy & Fuels; Engineering, Mechanical SC Energy & Fuels; Engineering GA BE6DW UT WOS:000373970600032 ER PT B AU Wierzbicki, TA Lee, IC Gupta, AK AF Wierzbicki, Teresa A. Lee, Ivan C. Gupta, Ashwani K. GP ASME TI CATALYTIC OXIDATION OF JET FUEL SURROGATES IN A MESO-SCALE COMBUSTOR SO PROCEEDINGS OF THE ASME POWER CONFERENCE, 2015 LA English DT Proceedings Paper CT ASME 2015 Power Conference, POWER2015 CY JUN 28-JUL 02, 2015 CL San Diego, CA SP ASME, Power Div DE Catalytic combustion; JP-8 surrogate; meso-scale combustion; reaction kinetics; hybrid combustion ID HEAT-RECIRCULATING COMBUSTORS; GAS SHIFT REACTION; LOW-TEMPERATURE; HIGHER HYDROCARBONS; METAL-CATALYSTS; PERFORMANCE; HEXADECANE; SYSTEM; DECANE; CELLS AB Oxidation behavior of dodecane and two mixtures of dodecane and m-xylene (90/10 wt. % and 80/20 wt. %) over an Rh catalyst in a meso-scale heat recirculating combustor was examined to isolate the effect of aromatic content on performance. The fuel conversion, product speciation and reaction kinetics were calculated, and the global combustion behavior observed. The results showed that increasing the amount of m-xylene in the fuel increased the fuel conversion from 85% (pure dodecane) to 92% (90/10) and further to 98% (80/20). The presence of xylene also significantly increased CO2/H2O selectivity and de-creased CO/H-2 selectivity. Global activation energy increased linearly with increase in xylene content, supporting that addition of aromatic species to fuel lowers the overall reactivity. The non-catalytic reaction was also simulated using Chemkin software to determine the effect of the Rh catalyst on the combustor performance. The results revealed that the catalyst promotes total oxidation over partial oxidation, and lowers the global activation energy by up to 70%. C1 [Wierzbicki, Teresa A.; Gupta, Ashwani K.] Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA. [Lee, Ivan C.] US Army Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD USA. RP Wierzbicki, TA (reprint author), Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA. NR 41 TC 0 Z9 0 U1 2 U2 2 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-5660-4 PY 2016 AR V001T03A006 PG 9 WC Energy & Fuels; Engineering, Mechanical SC Energy & Fuels; Engineering GA BE6DW UT WOS:000373970600026 ER PT J AU Krakauer, T AF Krakauer, Teresa TI Enterotoxins: Microbial Proteins and Host Cell Dysregulation SO TOXINS LA English DT Editorial Material DE staphylococcal superantigens; clostridial toxins; receptor binding; toxicity; inflammation; therapeutics ID PERFRINGENS BETA-TOXIN; CLOSTRIDIUM; TOXICITY; BINDING; SUPERANTIGENS; DOMAIN C1 [Krakauer, Teresa] US Army, Med Res Inst Infect Dis, Dept Immunol, Mol Translat Sci Div, Ft Detrick, MD 21702 USA. RP Krakauer, T (reprint author), US Army, Med Res Inst Infect Dis, Dept Immunol, Mol Translat Sci Div, Ft Detrick, MD 21702 USA. EM Teresa.krakauer.civ@mail.mil NR 16 TC 0 Z9 0 U1 1 U2 1 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 2072-6651 J9 TOXINS JI Toxins PD JAN PY 2016 VL 8 IS 1 AR 17 DI 10.3390/toxins8010017 PG 4 WC Toxicology SC Toxicology GA DJ6OL UT WOS:000374332700017 ER PT J AU Hohenforst-Schmidt, W Zarogoulidis, P Pitsiou, G Linsmeier, B Tsavlis, D Kioumis, I Papadaki, E Freitag, L Tsiouda, T Turner, JF Browning, R Simoff, M Sachpekidis, N Tsakiridis, K Zaric, B Yarmus, L Baka, S Stratakos, G Rittger, H AF Hohenforst-Schmidt, Wolfgang Zarogoulidis, Paul Pitsiou, Georgia Linsmeier, Bernd Tsavlis, Drosos Kioumis, Ioannis Papadaki, Eleni Freitag, Lutz Tsiouda, Theodora Turner, J. Francis Browning, Robert Simoff, Michael Sachpekidis, Nikolaos Tsakiridis, Kosmas Zaric, Bojan Yarmus, Lonny Baka, Sofia Stratakos, Grigoris Rittger, Harald TI Drug Eluting Stents for Malignant Airway Obstruction: A Critical Review of the Literature SO JOURNAL OF CANCER LA English DT Review DE pharmacology; stents ID CELL LUNG-CANCER; PERCUTANEOUS CORONARY INTERVENTION; EVEROLIMUS PLUS EXEMESTANE; BARE-METAL STENTS; BODY-SURFACE AREA; OPTICAL COHERENCE TOMOGRAPHY; FLUOROURACIL DOSE ADJUSTMENT; METASTATIC COLORECTAL-CANCER; NON-INFERIORITY TRIAL; LONG-TERM OUTCOMES AB Lung cancer being the most prevalent malignancy in men and the 3rd most frequent in women is still associated with dismal prognosis due to advanced disease at the time of diagnosis. Novel targeted therapies are already on the market and several others are under investigation. However non-specific cytotoxic agents still remain the cornerstone of treatment for many patients. Central airways stenosis or obstruction may often complicate and decrease quality of life and survival of these patients. Interventional pulmonology modalities (mainly debulking and stent placement) can alleviate symptoms related to airways stenosis and improve the quality of life of patients. Mitomycin C and sirolimus have been observed to assist a successful stent placement by reducing granuloma tissue formation. Additionally, these drugs enhance the normal tissue ability against cancer cell infiltration. In this mini review we will concentrate on mitomycin C and sirolimus and their use in stent placement. C1 [Hohenforst-Schmidt, Wolfgang; Rittger, Harald] Univ Erlangen Nurnberg, Fuerth Hosp, Med Clin 1, Furth, Germany. [Zarogoulidis, Paul; Pitsiou, Georgia; Tsavlis, Drosos; Kioumis, Ioannis; Papadaki, Eleni; Tsiouda, Theodora] Aristotle Univ Thessaloniki, G Papanikolaou Gen Hosp, Dept Pulm, Oncol Unit, GR-54006 Thessaloniki, Greece. [Linsmeier, Bernd] Coburg Clin, Dept Gen Surg, Coburg, Germany. [Freitag, Lutz] Univ Essen Duisburg, Univ Hosp Essen, Ruhrlandklin, Dept Intervent Pneumol, Tueschener Weg 40, D-45239 Essen, Germany. [Turner, J. Francis] Western Reg Med Ctr, Canc Treatment Ctr Amer, Div Intervent Pulmonol & Med Oncol, Goodyear, AZ USA. [Browning, Robert] Walter Reed Army Med Ctr, Natl Naval Med Ctr, Pulm & Crit Care Med, Intervent Pulmonol, Bethesda, MD USA. [Simoff, Michael] Wayne State Univ, Henry Ford Hosp, Sch Med, Bronchoscopy & Intervent Pulmonol,Pulm & Crit Car, Detroit, MI 48202 USA. [Sachpekidis, Nikolaos; Tsakiridis, Kosmas] St Luke Private Hosp, Dept Cardiothorac Surg, Thessaloniki, Panorama, Greece. [Zaric, Bojan] Univ Novi Sad, Fac Med, Clin Thorac Oncol, Inst Pulm Dis Vojvodina, Novi Sad 21000, Serbia. [Yarmus, Lonny] Sheikh Zayed Cardiovasc & Crit Care Tower, Div Pulm & Crit Care Med, Baltimore, MD USA. [Baka, Sofia] Interbalkan European Med Ctr, Dept Oncol, Thessaloniki, Greece. [Stratakos, Grigoris] Natl Univ Athens, Sotiria Gen Hosp Athens, Resp Med Dept 1, Athens, Greece. RP Zarogoulidis, P (reprint author), Aristotle Univ Thessaloniki, G Papanikolaou Gen Hosp, Dept Pulm, Oncol Unit, GR-54006 Thessaloniki, Greece. EM pzarog@hotmail.com NR 149 TC 5 Z9 5 U1 5 U2 8 PU IVYSPRING INT PUBL PI LAKE HAVEN PA PO BOX 4546, LAKE HAVEN, NSW 2263, AUSTRALIA SN 1837-9664 J9 J CANCER JI J. Cancer PY 2016 VL 7 IS 4 BP 377 EP 390 DI 10.7150/jca.13611 PG 14 WC Oncology SC Oncology GA DI3YX UT WOS:000373438000004 PM 26918052 ER PT J AU Doyle, JD Howard, IL AF Doyle, Jesse D. Howard, Isaac L. TI Characterization of Dense-Graded Asphalt With the Cantabro Test SO JOURNAL OF TESTING AND EVALUATION LA English DT Article DE asphalt mixture; flexible pavements; reclaimed asphalt pavement; warm mix asphalt ID FRICTION COURSE MIXTURES; MIX DESIGN; PERFORMANCE AB Durability of dense-graded asphalt (DGA) is a key issue with regards to long term pavement performance. There is a need for a practical and implementable test to estimate these parameters. Previous research has suggested that the Cantabro abrasion loss test has potential for this application. Both the development of the Cantabro method and its conventional application to open-graded friction course (OGFC) mixtures are reviewed. A four component research approach was undertaken to evaluate suitability of the Cantabro test for DGA mixtures that included testing of 438 specimens from 69 different mixtures. First, sensitivity of the test was assessed using a large range of typical Mississippi DGA mixtures. Second, variability of the test was measured by evaluating data sets with thirty replicates. Third, the effects of oven conditioning protocols were measured. Fourth, the effects of varying reclaimed asphalt pavement (RAP) contents were measured for warm-mix asphalt (WMA). The overall recommendation from the research was that the Cantabro test be given serious consideration for use as a durability measurement tool for DGA mixtures. C1 [Doyle, Jesse D.] US Army Corps Engn, Engineer Res & Dev Ctr, CEERD GM A, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. [Howard, Isaac L.] Mississippi State Univ, Dept Civil & Environm Engn, Mat & Construct Ind Chair, 501 Hardy Rd,POB 9546, Mississippi State, MS 39762 USA. RP Howard, IL (reprint author), Mississippi State Univ, Dept Civil & Environm Engn, Mat & Construct Ind Chair, 501 Hardy Rd,POB 9546, Mississippi State, MS 39762 USA. EM ilhoward@cee.msstate.edu FU MDOT [212] FX This research was largely funded by MDOT under State Study 212 and principal investigator Isaac L. Howard. Permission to publish was granted by the Director, Geotechnical and Structures Laboratory, U.S. Army Engineer Research and Development Center. NR 33 TC 0 Z9 0 U1 4 U2 6 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 USA SN 0090-3973 EI 1945-7553 J9 J TEST EVAL JI J. Test. Eval. PD JAN PY 2016 VL 44 IS 1 BP 77 EP 88 DI 10.1520/JTE20140212 PG 12 WC Materials Science, Characterization & Testing SC Materials Science GA DJ0RG UT WOS:000373911500008 ER PT J AU Toblin, RL Anderson, JA Riviere, LA McGurk, D Sipos, ML AF Toblin, Robin L. Anderson, James A. Riviere, Lyndon A. McGurk, Dennis Sipos, Maurice L. TI The Impact of Unit Membership on Smoking Among Soldiers SO MILITARY MEDICINE LA English DT Article ID TOBACCO USE; US MILITARY; QUALITATIVE-ANALYSIS; CIGARETTE-SMOKING; STATES-ARMY; ASSOCIATION; PREVALENCE; PERSONNEL; PEER AB Cultural, organizational, and dyadic influences have been found to be associated with smoking in the military while group-level influences have been identified in the general population. However, there are few studies examining group-level influences in the military and none using group-level analyses. Such studies are essential for understanding how to optimally forestall or cease smoking. This study, using mixed effects modelling, examined whether unit membership influenced smoking behavior in soldiers from brigade combat teams. Unit membership was assessed in 2008 to 2009 at the company level (n = 2204) and in 2012 at the platoon level (n = 452). Smoking was assessed by the number of daily cigarettes smoked (range: 0-99) with smoking status (nonsmoker vs. smoker) and smoking level (none, smoker, and heavy [20 + cigarettes/day]) as the outcomes. For both samples, unit membership was not significantly associated with a soldier's propensity to smoke when comparing either all smokers to nonsmokers or heavy smokers to smokers. These results suggest typical military unit-level training programs are unlikely to be the most effective mode of intervention for smoking prevention or cessation. Smoking rates in the military may be influenced instead by small group or individual relationships or by overall military culture. C1 [Toblin, Robin L.; Anderson, James A.; Riviere, Lyndon A.; Sipos, Maurice L.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. [Toblin, Robin L.] US PHS, Commissioned Corps, 1101 Wootton Pkwy,Plaza Level, Rockville, MD 20852 USA. [McGurk, Dennis] US Army Med Res & Mat Command, Mil Operat Med Res Program, 504 Scott St, Ft Detrick, MD 21702 USA. RP Toblin, RL (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. FU U.S. Army Medical Research and Materiel Command (USAMRMC) FX We would like to thank COL (Ret.) Paul Bliese, PhD of the University of South Carolina for his statistical advice, the Joint Mental Health Advisory Team-8 that collected data in Afghanistan in 2012 (Team Commander: LTC Dennis McGurk, a co-author), and the soldiers and units that participated in data collection. This work was supported by the U.S. Army Medical Research and Materiel Command (USAMRMC) for intramural funding that supports enhancing the psychological resilience of the warfighter. USAMRMC did not have any specific role in this manuscript. NR 35 TC 1 Z9 1 U1 0 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JAN PY 2016 VL 181 IS 1 BP 16 EP 20 DI 10.7205/MILMED-D-15-00063 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA DI3MZ UT WOS:000373404100007 PM 26741472 ER PT J AU Barnes, VA Monto, A Williams, JJ Rigg, JL AF Barnes, Vernon A. Monto, Andrea Williams, Jennifer J. Rigg, John L. TI Impact of Transcendental Meditation on Psychotropic Medication Use Among Active Duty Military Service Members With Anxiety and PTSD SO MILITARY MEDICINE LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; BLOOD-PRESSURE; VETERANS; REDUCTION; EFFICACY; TRIAL AB The purpose of the study was to determine whether the regular practice of Transcendental Meditation (TM) decreased the need for psychotropic medications required for anxiety and post-traumatic stress disorder (PTSD) management and increased psychological wellbeing. The sample included 74 military Service Members with documented PTSD or anxiety disorder not otherwise specified (ADNOS), 37 that practiced TM and 37 that did not. At 1 month, 83.7% of the TM group stabilized, decreased, or ceased medications and 10.8% increased medication dosage; compared with 59.4% of controls that showed stabilizations, decreases, or cessations; and 40.5% that increased medications (p < 0.03). A similar pattern was observed after 2 (p < 0.27), 3 (p < 0.002), and 6 months (p < 0.34). Notably, there was a 20.5% difference between groups in severity of psychological symptoms after 6 months, that is, the control group experienced an increase in symptom severity compared with the group practicing TM. These findings provide insight into the benefits of TM as a viable treatment modality in military treatment facilities for reducing PTSD and ADNOS psychological symptoms and associated medication use. C1 [Barnes, Vernon A.] Georgia Regents Univ, Georgia Prevent Inst, HS1640, Augusta, GA 30912 USA. [Monto, Andrea] Pearl Kruse Way, 4550 Carman Dr, Lake Oswego, OR 97035 USA. [Williams, Jennifer J.; Rigg, John L.] Dwight D Eisenhower Army Med Ctr, Neurosci & Rehabil Ctr, Traumat Brain Injury Clin, Ft Gordon, GA 30905 USA. RP Barnes, VA (reprint author), Georgia Regents Univ, Georgia Prevent Inst, HS1640, Augusta, GA 30912 USA. FU David Lynch Foundation Operation Warrior Wellness FX Funding for Transcendental Meditation training was provided by the David Lynch Foundation Operation Warrior Wellness. NR 30 TC 0 Z9 0 U1 8 U2 12 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JAN PY 2016 VL 181 IS 1 BP 56 EP 63 DI 10.7205/MILMED-D-14-00333 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA DI3MZ UT WOS:000373404100012 PM 26741477 ER PT J AU Mallory, R Jackson, JL Mondragon, D Hatzigeorgiou, C DeZee, KJ Greenburg, D O'Malley, PG AF Mallory, Renee Jackson, Jeffrey L. Mondragon, Donald Hatzigeorgiou, Christos DeZee, Kent J. Greenburg, David O'Malley, Patrick G. TI Characteristics of Highly Rated Internal Medicine Attendings Before and After the 2004 Work-Hour Restrictions SO MILITARY MEDICINE LA English DT Article ID RESIDENT DUTY-HOURS; NEW-YORK-STATE; AMBULATORY-CARE; CLINICAL TEACHERS; FACULTY; ROUNDS; IMPACT; PERCEPTIONS; REGULATIONS; SUPERVISION AB Objectives: To describe the characteristics of top-rated Internal Medicine attendings and whether they changed after implementation of the 2004 work-hour restrictions. Methods: Mixed methods study of resident ratings of medicine attendings (Period 1: 1994-1996, n = 250 and Period 2: 2007-2009, n = 152). Residents evaluated 17 attending characteristics. The top 25% of "overall" ratings were classified as "highly rated." Two free-text questions included "What was your attending's best characteristic?" and "How could your attending best improve?" and were coded in duplicate, using grounded qualitative methods. Results: There were no differences in the characteristics of highly rated attendings in the two time periods. Characteristics associated with being a top-rated attending included enthusiasm (odds ratio [OR]: 5.69, 2.78-11.67), balanced teaching style (OR: 3.63, 1.64-8.02), promoting independent thinking (OR: 2.90, 0.96-8.74), fund of knowledge (OR: 2.73, 1.13-6.58), and time management (OR: 1.78, 1.14-2.80). Among the 1,410 utterances, valued attending attributes included helpfulness, promoting independent thinking, and having strong medical knowledge. Conclusions: The characteristics valued by residents in attendings did not change over time despite a major structural change in work hours and patterns of teaching. These valued characteristics continue to be a strong general fund of knowledge, enthusiasm for teaching, and balance between didactic and bedside approaches. C1 [Mallory, Renee] Walter Reed Natl Mil Med Ctr, Dept Med, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. [Jackson, Jeffrey L.] Zablocki VAMC, Dept Med, 5000 W Natl Ave, Milwaukee, WI 53295 USA. [Mondragon, Donald; Hatzigeorgiou, Christos] Dwight D Eisenhower Med Ctr, Dept Med, 300 East Hosp Rd, Ft Gordon, GA 30905 USA. [DeZee, Kent J.] Tripler Army Med Ctr, Grad Med Educ, 1 Jarrett White Rd, Honolulu, HI 96859 USA. [Greenburg, David] Uniformed Serv Univ Hlth Sci, Dept Ophthalmol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. [O'Malley, Patrick G.] Uniformed Serv Univ Hlth Sci, Dept Med, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. RP Mallory, R (reprint author), Walter Reed Natl Mil Med Ctr, Dept Med, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. NR 39 TC 0 Z9 0 U1 1 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JAN PY 2016 VL 181 IS 1 BP 76 EP 81 DI 10.7205/MILMED-D-14-00445 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA DI3MZ UT WOS:000373404100015 PM 26741480 ER PT J AU Cutter, L AF Cutter, Laura TI Walter Reed, Yellow Fever, and Informed Consent SO MILITARY MEDICINE LA English DT Editorial Material C1 [Cutter, Laura] US Army Med Res & Mat Command, Natl Museum Hlth & Med, Amer Registry Pathol, 2500 Linden Lane, Silver Spring, MD 20910 USA. RP Cutter, L (reprint author), US Army Med Res & Mat Command, Natl Museum Hlth & Med, Amer Registry Pathol, 2500 Linden Lane, Silver Spring, MD 20910 USA. NR 2 TC 0 Z9 0 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JAN PY 2016 VL 181 IS 1 BP 90 EP 91 DI 10.7205/MILMED-D-15-00430 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA DI3MZ UT WOS:000373404100017 PM 26741482 ER PT J AU House, JM AF House, Jonathan M. TI Marshal K. K. Rokossovsky: The Red Army's Gentleman Commander. SO RUSSIAN REVIEW LA English DT Book Review C1 [House, Jonathan M.] US Army Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP House, JM (reprint author), US Army Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0036-0341 EI 1467-9434 J9 RUSS REV JI Russ. Rev. PD JAN PY 2016 VL 75 IS 1 BP 164 EP 166 PG 3 WC History SC History GA DI6LH UT WOS:000373609900030 ER PT J AU Lambert, AE Watson, JM Stefanucci, JK Ward, N Bakdash, JZ Strayer, DL AF Lambert, Ann E. Watson, Jason M. Stefanucci, Jeanine K. Ward, Nathan Bakdash, Jonathan Z. Strayer, David L. TI Stereotype Threat Impairs Older Adult Driving SO APPLIED COGNITIVE PSYCHOLOGY LA English DT Article ID WORKING-MEMORY CAPACITY; DRIVER DISTRACTION; SIMULATOR SICKNESS; PERFORMANCE; MATH; TASK; ATTENTION; PRESSURE; MULTITASKING; PROFILES AB Stereotypes can harm human performance, especially when activated in individuals with diminished working memory capacity (WMC). Performance implications for the stereotype of poor driving in older adults were investigated. Using a sample of older adults, WMC (the ability to maintain task goals and ignore distractions) and driving performance [brake reaction time (RT), following distance, and crashes] were assessed, the latter using a high-fidelity simulator. Elderly participants under stereotype threat with reduced WMC exhibited slower brake RTs and longer following distances compared with a control condition that was not threatened. This driving profile was characteristic of cognitive distraction. Stereotype threat has clear consequences for human performance in a common real-world task-driving-that is critical to public safety. Furthermore, these findings suggest caution in how the media and public policy communicate information about older adult driving. Copyright (c) 2015 John Wiley & Sons, Ltd. C1 [Lambert, Ann E.; Watson, Jason M.; Stefanucci, Jeanine K.; Ward, Nathan; Bakdash, Jonathan Z.; Strayer, David L.] Univ Utah, Dept Psychol, Salt Lake City, UT 84112 USA. [Watson, Jason M.] Univ Utah, Inst Brain, Salt Lake City, UT USA. [Watson, Jason M.] Univ Utah, Ctr Aging, Salt Lake City, UT USA. [Bakdash, Jonathan Z.] US Army, Res Lab, Adelphi, MD USA. RP Watson, JM (reprint author), Univ Colorado, Dept Psychol, Campus Box 173,POB 173364, Denver, CO 80217 USA. EM jason.watson@ucdenver.edu NR 39 TC 2 Z9 2 U1 3 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0888-4080 EI 1099-0720 J9 APPL COGNITIVE PSYCH JI Appl. Cogn. Psychol. PD JAN-FEB PY 2016 VL 30 IS 1 BP 22 EP 28 DI 10.1002/acp.3162 PG 7 WC Psychology, Experimental SC Psychology GA DH6FK UT WOS:000372886200003 ER PT J AU Davis, SJ Edwards, SB Teper, GE Bassett, DG McCarthy, MJ Johnson, SC Lawton, CR Hoffman, MJ Shelton, L Henry, SM Melander, DJ Muldoon, FM Alford, BD Rice, RE AF Davis, Scott J. Edwards, Shatiel B. Teper, Gerald E. Bassett, David G. McCarthy, Michael J. Johnson, Scott C. Lawton, Craig R. Hoffman, Matthew J. Shelton, Liliana Henry, Stephen M. Melander, Darryl J. Muldoon, Frank M. Alford, Brian D. Rice, Roy E. TI Maximizing the US Army's Future Contribution to Global Security Using the Capability Portfolio Analysis Tool (CPAT) SO INTERFACES LA English DT Article DE US Army; ground combat systems; portfolio optimization; fleet scheduling; decision support; mixed-integer linear programming AB Recent budget reductions have posed tremendous challenges to the U.S. Army in managing its portfolio of ground combat systems (tanks and other fighting vehicles), thus placing many important programs at risk. To address these challenges, the Army and a supporting team developed and applied the Capability Portfolio Analysis Tool (CPAT) to optimally invest in ground combat modernization over the next 25-35 years. CPAT provides the Army with the analytical rigor needed to help senior Army decision makers allocate scarce modernization dollars to protect soldiers and maintain capability overmatch. CPAT delivers unparalleled insight into multiple-decade modernization planning using a novel multiphase mixed-integer linear programming technique and illustrates a cultural shift toward analytics in the Army's acquisition thinking and processes. CPAT analysis helped shape decisions to continue modernization of the $10 billion Stryker family of vehicles (originally slated for cancellation) and to strategically reallocate over $20 billion to existing modernization programs by not pursuing the Ground Combat Vehicle program as originally envisioned. More than 40 studies have been completed using CPAT, applying operations research methods to optimally prioritize billions of taxpayer dollars and allowing Army acquisition executives to base investment decisions on analytically rigorous evaluations of portfolio trade-offs. C1 [Davis, Scott J.; Edwards, Shatiel B.; Teper, Gerald E.; Bassett, David G.; McCarthy, Michael J.; Johnson, Scott C.] United States Army, Warren, MI 48397 USA. [Lawton, Craig R.; Hoffman, Matthew J.; Shelton, Liliana; Henry, Stephen M.; Melander, Darryl J.; Muldoon, Frank M.] Sandia Natl Labs, POB 5800, Albuquerque, NM 87185 USA. [Alford, Brian D.] Booz Allen Hamilton, Huntsville, AL 35806 USA. [Rice, Roy E.] Teledyne Brown Engn Inc, Huntsville, AL 35805 USA. RP Davis, SJ; Edwards, SB; Teper, GE; Bassett, DG; McCarthy, MJ; Johnson, SC (reprint author), United States Army, Warren, MI 48397 USA.; Lawton, CR; Hoffman, MJ; Shelton, L; Henry, SM; Melander, DJ; Muldoon, FM (reprint author), Sandia Natl Labs, POB 5800, Albuquerque, NM 87185 USA.; Alford, BD (reprint author), Booz Allen Hamilton, Huntsville, AL 35806 USA.; Rice, RE (reprint author), Teledyne Brown Engn Inc, Huntsville, AL 35805 USA. EM scott.j.davis.civ@mail.mil; shatiel.b.edwards.civ@mail.mil; gerald.e.teper.civ@mail.mil; david.g.bassett.mil@mail.mil; michael.j.mccarthy.civ@mail.mil; scott.c.johnson98.civ@mail.mil; crlawto@sandia.gov; mjhoffm@sandia.gov; lshelto@sandia.gov; smhenry@sandia.gov; djmelan@sandia.gov; fmmuldo@sandia.gov; alford_brian@bah.com; roy.rice@teledyne.com FU U.S. Department of Energy's National Nuclear Security Administration [DE-AC04-94AL85000] FX The authors thank the Edelman selection committee, their coaches Randy Robinson and Greg Parlier, John Milne and Alice Mack for their valuable editorial feedback, Brent Peterson for his outstanding video production work, and David Cunnington and Daniel Thompson for their graphics and presentation expertise. The authors especially thank the Honorable Ms. Heidi Shyu and Lt. Gen. Michael Williamson for their video remarks supporting the impacts of the CPAT project. Sandia National Laboratories is a multiprogram laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration [Contract DE-AC04-94AL85000]. NR 12 TC 0 Z9 0 U1 2 U2 5 PU INFORMS PI CATONSVILLE PA 5521 RESEARCH PARK DR, SUITE 200, CATONSVILLE, MD 21228 USA SN 0092-2102 EI 1526-551X J9 INTERFACES JI Interfaces PD JAN-FEB PY 2016 VL 46 IS 1 SI SI BP 91 EP 108 DI 10.1287/inte.2015.0824 PG 18 WC Management; Operations Research & Management Science SC Business & Economics; Operations Research & Management Science GA DH9QN UT WOS:000373130900007 ER PT J AU Varghese, A Yakimov, M Tokranov, V Mitin, V Sablon, K Sergeev, A Oktyabrsky, S AF Varghese, A. Yakimov, M. Tokranov, V. Mitin, V. Sablon, K. Sergeev, A. Oktyabrsky, S. TI Complete voltage recovery in quantum dot solar cells due to suppression of electron capture SO NANOSCALE LA English DT Article ID BUILT-IN CHARGE; MULTIPHONON PROCESSES; RELAXATION; ENHANCEMENT; DEPENDENCE; EFFICIENCY; GAAS AB Extensive investigations in recent years have shown that addition of quantum dots (QDs) to a single-junction solar cell decreases the open circuit voltage, V-OC, with respect to the reference cell without QDs. Despite numerous efforts, the complete voltage recovery in QD cells has been demonstrated only at low temperatures. To minimize the V-OC reduction, we propose and investigate a new approach that combines nanoscale engineering of the band structure and the potential profile. Our studies of GaAs solar cells with various InAs QD media demonstrate that the main cause of the V-OC reduction is the fast capture of photoelectrons from the GaAs conduction band (CB) to the localized states in QDs. As the photoelectron capture into QDs is mainly realized via the wetting layers (WLs), we substantially reduced the WLs using two monolayer AlAs capping of QDs. In the structures with reduced WLs, the direct CB-to-QD capture is further suppressed due to charging of QDs via doping of the interdot space. The QD devices with suppressed photoelectron capture show the same V-OC as the GaAs reference cell together with some improvements in the short circuit current. C1 [Varghese, A.; Yakimov, M.; Tokranov, V.; Oktyabrsky, S.] SUNY Polytech Inst, Albany, NY 12203 USA. [Mitin, V.] SUNY Buffalo, Buffalo, NY 14260 USA. [Sablon, K.; Sergeev, A.] US Army Res Lab, Adelphi, MD 20783 USA. RP Sergeev, A (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM asergeev@buffalo.edu FU National Science Foundation [ECS-1236459]; NRC FX This research was supported by the National Science Foundation under grant ECS-1236459. AS acknowledges support from NRC. NR 43 TC 1 Z9 1 U1 2 U2 16 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2040-3364 EI 2040-3372 J9 NANOSCALE JI Nanoscale PY 2016 VL 8 IS 13 BP 7248 EP 7256 DI 10.1039/c5nr07774e PG 9 WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA DH8QO UT WOS:000373060600039 PM 26974517 ER PT J AU Kula, RR Harms, NE AF Kula, Robert R. Harms, Nathan E. TI A NEW SPECIES OF CHAENUSA HALIDAY SENSU LATO (HYMENOPTERA: BRACONIDAE) FROM THE NEARCTIC REGION SO PROCEEDINGS OF THE ENTOMOLOGICAL SOCIETY OF WASHINGTON LA English DT Article DE Alysiinae; biological control; Dacnusini; Hydrellia; parasitoid; Sagittaria latifolia; taxonomy ID DISTRIBUTION RECORDS; ALYSIINAE; REVISION; HYDROCHARITACEAE; DIPTERA AB Chaenusa psillosae Kula, new species from the Nearctic Region is described. Specimens upon which the new species is described were reared from an undetermined species of Hydrellia Robineau-Desvoidy infesting Sagittaria latifolia Willd. A key to the New World species of Chaenusa sensu lato is amended to include the new species. C1 [Kula, Robert R.] Smithsonian Inst, Systemat Entomol Lab, Beltsville Agr Res Ctr, Agr Res Serv,US Dept Agr,Natl Museum Nat Hist, POB 37012,MRC-168, Washington, DC 20013 USA. [Harms, Nathan E.] US Army, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Kula, RR (reprint author), Smithsonian Inst, Systemat Entomol Lab, Beltsville Agr Res Ctr, Agr Res Serv,US Dept Agr,Natl Museum Nat Hist, POB 37012,MRC-168, Washington, DC 20013 USA.; Harms, NE (reprint author), US Army, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. EM Robert.Kula@ars.usda.gov; Nathan.e.harms@usace.army.mil NR 15 TC 0 Z9 0 U1 0 U2 0 PU ENTOMOL SOC WASHINGTON PI WASHINGTON PA SMITHSONIAN INSTITUTION DEPT ENTOMOLOGY, WASHINGTON, DC 20560 USA SN 0013-8797 J9 P ENTOMOL SOC WASH JI Proc. Entomol. Soc. Wash. PD JAN PY 2016 VL 118 IS 1 BP 101 EP 108 DI 10.4289/0013-8797.118.1.101 PG 8 WC Entomology SC Entomology GA DI1FU UT WOS:000373242800006 ER PT J AU Caudle, KL Lu, XCM Mountney, A Shear, DA Tortella, FC AF Caudle, Krista L. Lu, Xi-Chun M. Mountney, Andrea Shear, Deborah A. Tortella, Frank C. TI Neuroprotection and anti-seizure effects of levetiracetam in a rat model of penetrating ballistic-like brain injury SO RESTORATIVE NEUROLOGY AND NEUROSCIENCE LA English DT Article DE Traumatic brain injury; post-traumatic seizures; neuroprotection; motor; cognitive function; rat ID ANTICONVULSANT DRUG LEVETIRACETAM; ACUTE NONCONVULSIVE SEIZURES; CEREBRAL-ARTERY OCCLUSION; CRITICALLY-ILL ADULTS; INTRAVENOUS LEVETIRACETAM; SUBARACHNOID HEMORRHAGE; ELECTROGRAPHIC SEIZURES; BARRIER PERMEABILITY; CONSENSUS STATEMENT; CORTICAL DYSPLASIA AB Purpose: We assessed the therapeutic efficacy of FDA-approved anti-epileptic drug Levetiracetam (LEV) to reduce post-traumatic nonconvulsive seizure (NCS) activity and promote neurobehavioral recovery following 10% frontal penetrating ballistic-like brain injury (PBBI) in male Sprague-Dawley rats. Methods: Experiment 1 anti-seizure study: 50 mg/kg LEV (25 mg/kg maintenance doses) was given twice daily for 3 days (LEV3D) following PBBI; outcome measures included seizures incidence, frequency, duration, and onset. Experiment 2 neuroprotection studies: 50 mg/kg LEV was given twice daily for either 3 (LEV3D) or 10 days (LEV10D) post-injury; outcome measures include motor (rotarod) and cognitive (water maze) functions. Results: LEV3D treatment attenuated seizure activity with significant reductions in NCS incidence (54%), frequency, duration, and delayed latency to seizure onset compared to vehicle treatment. LEV3D treatment failed to improve cognitive or motor performance; however extending the dosing regimen through 10 days post-injury afforded significant neuroprotective benefit. Animals treated with the extended LEV10D dosing regimen showed a twofold improvement in rotarod task latency to fall as well as significantly improved spatial learning performance (24%) in the MWM task. Conclusions: These findings support the dual anti-seizure and neuroprotective role of LEV, but more importantly identify the importance of an extended dosing protocol which was specific to the therapeutic targets studied. C1 [Caudle, Krista L.; Lu, Xi-Chun M.; Mountney, Andrea; Shear, Deborah A.; Tortella, Frank C.] Walter Reed Army Inst Res, Brain Trauma Neuroprotect & Neurorestorat Branch, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. RP Caudle, KL (reprint author), Walter Reed Army Inst Res, Brain Trauma Neuroprotect & Neurorestorat Branch, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM krista.l.caudle.civ@mail.mil FU United States Army [W81XWH-10-1-0623] FX This work was supported by the United States Army [grant number W81XWH-10-1-0623]. NR 55 TC 0 Z9 0 U1 0 U2 2 PU IOS PRESS PI AMSTERDAM PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS SN 0922-6028 EI 1878-3627 J9 RESTOR NEUROL NEUROS JI Restor. Neurol. Neurosci. PY 2016 VL 34 IS 2 BP 257 EP 270 DI 10.3233/RNN-150580 PG 14 WC Neurosciences SC Neurosciences & Neurology GA DI3JG UT WOS:000373394300009 PM 26890099 ER PT J AU Meyer, ES Characklis, GW Brown, C Moody, P AF Meyer, Eliot S. Characklis, Gregory W. Brown, Casey Moody, Paul TI Hedging the financial risk from water scarcity for Great Lakes shipping SO WATER RESOURCES RESEARCH LA English DT Article ID WEATHER INDEX INSURANCE; COST-EFFECTIVENESS; CLIMATE-CHANGE; DROUGHT; PRECIPITATION; TRANSPORT; REGION AB Low water levels in the Great Lakes have recently had significant financial impacts on the region's commercial shipping, which transports hundreds of millions of dollars' worth of bulk goods each year. Cargo capacity is a function of a ship's draft, the distance between water level and the ship's bottom, and lower water levels force ships to reduce cargo loads to prevent running aground in shallow harbors and locks. Financial risk transfer instruments, such as index-based insurance contracts, may provide an adaptable method for managing these financial risks. In this work, a relationship between water levels and shipping revenues is developed and used in an actuarial analysis of the frequency and magnitude of revenue losses. This analysis is used to develop a standardized suite of binary financial contracts, which are indexed to water levels and priced according to predefined thresholds. These contracts are then combined to form hedging portfolios with different objectives for the shippers. Results suggest that binary contracts could substantially reduce the risk of financial losses during low lake level periods and at a relatively low cost of only one to three percent of total revenues, depending on coverage level. C1 [Meyer, Eliot S.; Characklis, Gregory W.] Univ N Carolina, Dept Environm Sci & Engn, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA. [Brown, Casey] Univ Massachusetts, Dept Civil & Environm Engn, Amherst, MA 01003 USA. [Moody, Paul] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. RP Meyer, ES (reprint author), Univ N Carolina, Dept Environm Sci & Engn, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA. EM eliot.meyer@unc.edu FU Hydro Research Foundation; Center for Watershed Science and Management (UNC) a part of the University of North Carolina's Institute for the Environment FX This research could not have been completed without the help of William Werick, the U.S. Army Corps of Engineers, the International Upper Great Lakes Study (IUGLS), and Andrew Gronewold. It was undertaken with the financial support of the Hydro Research Foundation and the Center for Watershed Science and Management (UNC), a part of the University of North Carolina's Institute for the Environment. All raw data used in this analysis can be found online. Historic lake levels are found through NOAA's GLERL (http://www.glerl.noaa.gov/data/dashboard/GLWLD.html), historic NBS data from IUGLS (http://www.iugls.org/tags?tag_id=438), as well as stochastic NBS (http://www.iugls.org/tags?tag_id=438). NR 64 TC 0 Z9 0 U1 3 U2 9 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0043-1397 EI 1944-7973 J9 WATER RESOUR RES JI Water Resour. Res. PD JAN PY 2016 VL 52 IS 1 BP 227 EP 245 DI 10.1002/2015WR017855 PG 19 WC Environmental Sciences; Limnology; Water Resources SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA DH9LO UT WOS:000373117800014 ER PT J AU Qian, LW Fourcaudot, AB Yamane, K You, T Chan, RK Leung, KP AF Qian, Li-Wu Fourcaudot, Andrea B. Yamane, Kazuyoshi You, Tao Chan, Rodney K. Leung, Kai P. TI Exacerbated and prolonged inflammation impairs wound healing and increases scarring SO WOUND REPAIR AND REGENERATION LA English DT Article ID RABBIT EAR; INJURY RESPONSES; DIABETIC WOUNDS; MODEL; REDUCTION; PRIVILEGE; THERAPY; DANGER; MATTER; REPAIR AB Altered inflammation in the early stage has long been assumed to affect subsequent steps of the repair process that could influence proper wound healing and remodeling. However, the lack of explicit experimental data makes the connection between dysregulated wound inflammation and poor wound healing elusive. To bridge this gap, we used the established rabbit ear hypertrophic scar model for studying the causal effect of dysregulated inflammation. We induced an exacerbated and prolonged inflammatory state in these wounds with the combination of trauma-related stimulators of pathogen-associated molecular patterns from heat-killed Pseudomonas aeruginosa and damage-associated molecular patterns from a dermal homogenate. In stimulated wounds, a heightened and lengthened inflammation was observed based on quantitative measurements of IL-6 expression, tissue polymorphonuclear leukocytes infiltration, and tissue myeloperoxidase activity. Along with the high level of inflammation, wound healing parameters (epithelial gap and others) at postoperative day 7 and 16 were significantly altered in stimulated wounds compared to unstimulated controls. By postoperative day 35, scar elevation of stimulated wounds was higher than that of control wounds (scar elevation index: 1.90 vs. 1.39, p<0.01). Moreover, treatment of these inflamed wounds with Indomethacin (at concentrations of 0.01, 0.1, and 0.4%) reduced scar elevation but with adverse effects of delayed wound closure and increased cartilage hypertrophy. In summary, successful establishment of this inflamed wound model provides a platform to understand these detrimental aspects of unchecked inflammation and to further test agents that can modulate local inflammation to improve wound outcomes. C1 [Qian, Li-Wu; Fourcaudot, Andrea B.; Yamane, Kazuyoshi; You, Tao; Chan, Rodney K.; Leung, Kai P.] US Army, Inst Surg Res, Dent & Trauma Res Detachment, 3698 Chambers Pass,Bldg 3610, Ft Sam Houston, TX 78234 USA. RP Leung, KP (reprint author), US Army, Inst Surg Res, Dent & Trauma Res Detachment, 3698 Chambers Pass,Bldg 3610, Ft Sam Houston, TX 78234 USA. EM kai.p.leung.civ@mail.mil FU US Army Medical Research and Material Command, Combat Casualty Care Research Directorate FX This work was supported by the US Army Medical Research and Material Command, Combat Casualty Care Research Directorate. NR 33 TC 8 Z9 8 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1067-1927 EI 1524-475X J9 WOUND REPAIR REGEN JI Wound Repair Regen. PD JAN-FEB PY 2016 VL 24 IS 1 BP 26 EP 34 DI 10.1111/wrr.12381 PG 9 WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery GA DH6TT UT WOS:000372925500003 PM 26562746 ER PT J AU DeCoste, JB Denny, MS Peterson, GW Mahle, JJ Cohen, SM AF DeCoste, Jared B. Denny, Michael S., Jr. Peterson, Gregory W. Mahle, John J. Cohen, Seth M. TI Enhanced aging properties of HKUST-1 in hydrophobic mixed-matrix membranes for ammonia adsorption SO CHEMICAL SCIENCE LA English DT Article ID METAL-ORGANIC FRAMEWORKS; REMOVAL; CU-3(BTC)(2); COMPOSITES; SURFACES; STORAGE; MOF AB Metal-organic frameworks (MOFs) in their free powder form have exhibited superior capacities for many gases when compared to other materials, due to their tailorable functionality and high surface areas. Specifically, the MOF HKUST-1 binds small Lewis bases, such as ammonia, with its coordinatively unsaturated copper sites. We describe here the use of HKUST-1 in mixed-matrix membranes (MMMs) prepared from polyvinylidene difluoride (PVDF) for the removal of ammonia gas. These MMMs exhibit ammonia capacities similar to their hypothetical capacities based on the weight percent of HKUST-1 in each MMM. HKUST-1 in its powder form is unstable toward humid conditions; however, upon exposure to humid environments for prolonged periods of time, the HKUST-1 MMMs exhibit outstanding structural stability, and maintain their ammonia capacity. Overall, this study has achieved all of the critical and combined elements for real-world applications of MOFs: high MOF loadings, fully accessible MOF surfaces, enhanced MOF stabilization, recyclability, mechanical stability, and processability. This study is a critical step in advancing MOFs to a stable, usable, and enabling technology. C1 [DeCoste, Jared B.; Peterson, Gregory W.; Mahle, John J.; Cohen, Seth M.] US Army Res Dev & Engn Command, Edgewood Chem Biol Ctr, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. [DeCoste, Jared B.] Leidos Inc, POB 68, Gunpowder, MD 21010 USA. [Denny, Michael S., Jr.; Cohen, Seth M.] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA. RP DeCoste, JB; Cohen, SM (reprint author), US Army Res Dev & Engn Command, Edgewood Chem Biol Ctr, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA.; DeCoste, JB (reprint author), Leidos Inc, POB 68, Gunpowder, MD 21010 USA.; Cohen, SM (reprint author), Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA. EM jared.b.decoste2.civ@mail.mil; scohen@ucsd.edu OI Cohen, Seth/0000-0002-5233-2280 FU Joint Science and Technology Office for Chemical Biological Defense [BA07PRO104]; Army Research Office [W911NF-15-1-0189] FX J. B. D., G. W. P. and J. J. M. thank the Joint Science and Technology Office for Chemical Biological Defense for funding under project number BA07PRO104. M. S. D. and S. M. C. acknowledge support from the Army Research Office award number W911NF-15-1-0189. All authors thank Mr Matthew Browe for conducting microbreakthrough experiments. NR 36 TC 7 Z9 7 U1 27 U2 80 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2041-6520 EI 2041-6539 J9 CHEM SCI JI Chem. Sci. PY 2016 VL 7 IS 4 BP 2711 EP 2716 DI 10.1039/c5sc04368a PG 6 WC Chemistry, Multidisciplinary SC Chemistry GA DH2KQ UT WOS:000372614800032 ER PT J AU Ramon, ES Tyo, JS Ziolkowski, RW Skipper, MC Abdalla, MD Martin, J AF Ramon, Eric S. Tyo, J. Scott Ziolkowski, Richard W. Skipper, Michael C. Abdalla, Michael D. Martin, Joshua TI Integration and Operation of an Electrically Small Magnetic EZ Antenna With a High-Power Standing Wave Oscillator Source SO IEEE ANTENNAS AND WIRELESS PROPAGATION LETTERS LA English DT Article DE Antennas; dipole antennas; high power micro-wave generation; pulse power systems AB The efficacy of the three-dimensional, rectangular magnetic EZ antenna for use with mesoband high-power microwave (HPM) sources has been demonstrated previously. It overcomes the typical bulky and massive impedance-matching components found currently in most HPM systems, making it an attractive option when space is very limited. However, its extremely compact nature presents practical challenges when dealing with extremely high-power sources due to the associated local field enhancements near the feed and the near-field resonant parasitic element. This letter presents a fully integrated, high-voltage source and radiating system that has several improvements in the antenna, source, and power system that have not before been demonstrated. The full system includes a ferroelectric generator, standing wave oscillator source, and electrically small antenna (ka = 0.37) operating at 510 MHz that can be packaged inside a 15-cm-diameter tube. This small diameter results in a quarter-wavelength-diameter ground plane, and the effects of this small ground plane on the radiation characteristics are explored. The development of a pressurized radome allows for operation at 73.6 kV, significantly higher than previous studies. C1 [Ramon, Eric S.; Ziolkowski, Richard W.] Univ Arizona, Coll Opt Sci, Tucson, AZ 85721 USA. [Ramon, Eric S.; Ziolkowski, Richard W.] Univ Arizona, Dept Elect & Comp Engn, Tucson, AZ 85721 USA. [Tyo, J. Scott] Univ New South Wales Canberra, Sch Engn & Informat Technol, Canberra, ACT 2600, Australia. [Skipper, Michael C.; Abdalla, Michael D.] ASR Corp, Albuquerque, NM 87048 USA. [Martin, Joshua] US Army, Space & Missile Def Command, Huntsville, AL 35649 USA. RP Tyo, JS (reprint author), Univ New South Wales Canberra, Sch Engn & Informat Technol, Canberra, ACT 2600, Australia. EM tyo@ieee.org NR 20 TC 0 Z9 0 U1 3 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1536-1225 EI 1548-5757 J9 IEEE ANTENN WIREL PR JI IEEE Antennas Wirel. Propag. Lett. PY 2016 VL 15 BP 642 EP 645 DI 10.1109/LAWP.2015.2465869 PG 4 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA DH2YS UT WOS:000372654100009 ER PT J AU Choi, JH Dagefu, FT Sadler, BM Sarabandi, K AF Choi, Jihun Dagefu, Fikadu T. Sadler, Brian M. Sarabandi, Kamal TI Electrically Small Folded Dipole Antenna for HF and Low-VHF Bands SO IEEE ANTENNAS AND WIRELESS PROPAGATION LETTERS LA English DT Article DE Antenna design; antenna fabrication; antenna measurement; electrically small antennas; folded dipole; low-VHF antennas ID MINIATURIZATION AB A novel, highly miniaturized, lightweight antenna operating at the low-VHF band is presented. Earlier studies on an extremely short HF monopole antenna consisting of two in-phase vertical elements face an inevitable issue regarding an unbalanced coaxial cable feed due to the very small ground plane [1]. To resolve this problem, as well as to achieve higher bandwidth, we introduce an electrically small folded dipole version of the same antenna having a fully balanced structure. The overall dimension and total mass of the proposed antenna are 10 x 10 x 15 cm(3). (0.013 lambda(0) x 0.013 lambda(0) x 0.02 lambda(0) at 40 MHz) and 98 g, respectively. The gain and pattern of the fabricated antenna are measured in an elevated range that is in nearly free-space conditions. Measurements are shown to be in good agreement with the design predictions from simulation. C1 [Choi, Jihun; Sarabandi, Kamal] Univ Michigan, Dept Elect Engn & Comp Sci, Radiat Lab, Ann Arbor, MI 48109 USA. [Dagefu, Fikadu T.; Sadler, Brian M.] Army Res Lab, Adelphi, MD 20783 USA. RP Choi, JH; Sarabandi, K (reprint author), Univ Michigan, Dept Elect Engn & Comp Sci, Radiat Lab, Ann Arbor, MI 48109 USA. EM jihchoi@umich.edu; saraband@eecs.umich.edu FU U.S. Army Research Laboratory [W911NF] FX This work was supported by the U.S. Army Research Laboratory under Contract W911NF and prepared through collaborative participation in the Microelectronics Center of Micro Autonomous Systems and Technology (MAST) Collaborative Technology Alliance (CTA). NR 12 TC 2 Z9 2 U1 1 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1536-1225 EI 1548-5757 J9 IEEE ANTENN WIREL PR JI IEEE Antennas Wirel. Propag. Lett. PY 2016 VL 15 BP 718 EP 721 DI 10.1109/LAWP.2015.2470215 PG 4 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA DH2YS UT WOS:000372654100028 ER PT J AU Barrett, DM Swanson, EP AF Barrett, David M. Swanson, Eric P. TI Did the CIA Reproduce 'Soviet Satellite' Imagery of the US During DCI McCone's Era? Evidence from a Document at the National Archives SO INTELLIGENCE AND NATIONAL SECURITY LA English DT Editorial Material AB The US developed the capability to see and reproduce photo imagery taken by Soviet satellites crossing the American landmass, according to notes of a conversation between DCI John McCone and Secretary of State Dean Rusk in 1963. We analyze the implications of this conversation, and report results of a literature search to explore how the US might have developed such a capability, and whether it lasted. C1 [Barrett, David M.] Villanova Univ, Polit Sci, Philadelphia, PA USA. [Swanson, Eric P.] US Army, Airborne Div 82, Adelphi, MD USA. [Swanson, Eric P.] NATOs Int Secur Assistance Force, Kabul, Afghanistan. RP Barrett, DM (reprint author), Villanova Univ, Polit Sci, Philadelphia, PA USA. EM david.barrett@villanova.edu NR 10 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0268-4527 EI 1743-9019 J9 INTELL NATL SECUR JI Intell. Natl. Secur. PY 2016 VL 31 IS 1 BP 131 EP 135 DI 10.1080/02684527.2015.1082241 PG 5 WC International Relations SC International Relations GA DH1HI UT WOS:000372534600009 ER PT J AU Cook, MT Auxier, JD Giminaro, AV Molgaard, JJ Knowles, JR Hall, HL AF Cook, Matthew T. Auxier, John D., II Giminaro, Andrew V. Molgaard, Joshua J. Knowles, Justin R. Hall, Howard L. TI A comparison of gamma spectra from trinitite versus irradiated synthetic nuclear melt glass SO JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY LA English DT Article DE Debris; Nuclear weapons; Nuclear forensics; Trinitite; Melt glass; Gamma spectroscopy ID DEVICE AB The development of realistic nuclear melt glass surrogates is important to the nuclear forensics community in order to establish analytical protocols for post-detonation analysis. In addition to creating surrogates that are accurate with regard to physical morphology and chemical composition, it is important to develop surrogates that also have similar radiological characteristics. A synthetic melt glass sample was irradiated at the High-Flux Isotope Reactor at Oak Ridge National Laboratory. This sample was counted twice using a semiconductor radiation detector to capture both fission-product signatures as well as those from neutron activation. A qualitative and quantitative analysis was performed to make recommendations for the next irradiation campaign. C1 [Cook, Matthew T.; Auxier, John D., II; Giminaro, Andrew V.; Hall, Howard L.] Univ Tennessee, Dept Nucl Engn, Knoxville, TN 37996 USA. [Auxier, John D., II; Hall, Howard L.] Univ Tennessee, Radiochem Ctr Excellence RCOE, Knoxville, TN 37996 USA. [Cook, Matthew T.; Auxier, John D., II; Giminaro, Andrew V.; Hall, Howard L.] Univ Tennessee, Inst Nucl Secur, Knoxville, TN 37996 USA. [Molgaard, Joshua J.] US Mil Acad, West Point, NY 10996 USA. [Knowles, Justin R.] Bredesen Ctr Interdisciplinary Res & Grad Educ, Knoxville, TN 37996 USA. RP Cook, MT (reprint author), Univ Tennessee, Dept Nucl Engn, Knoxville, TN 37996 USA.; Cook, MT (reprint author), Univ Tennessee, Inst Nucl Secur, Knoxville, TN 37996 USA. EM mcook4@vols.utk.edu OI Cook, Matthew/0000-0002-3460-5011; Knowles, Justin/0000-0001-7396-137X; Hall, Howard/0000-0002-4080-5159; Auxier II, John /0000-0001-6234-6451 FU Stewardship Science Academic Alliances (SSAA) Program of the U.S. Department of Energy (DOE) National Nuclear Security Administration (NNSA) [DE-NA000198] FX This work was performed under grant DE-NA000198 from the Stewardship Science Academic Alliances (SSAA) Program of the U.S. Department of Energy (DOE) National Nuclear Security Administration (NNSA). All views, opinions, and findings are those of the authors and do not necessary reflect those of the DOE and the NNSA. The authors would also like to gratefully acknowledge the efforts of Mr. David Glasgow of the HFIR at ORNL for their help in irradiating the surrogate samples and subsequent gamma-ray measurements. NR 13 TC 0 Z9 0 U1 2 U2 9 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0236-5731 EI 1588-2780 J9 J RADIOANAL NUCL CH JI J. Radioanal. Nucl. Chem. PD JAN PY 2016 VL 307 IS 1 BP 259 EP 267 DI 10.1007/s10967-015-4266-3 PG 9 WC Chemistry, Analytical; Chemistry, Inorganic & Nuclear; Nuclear Science & Technology SC Chemistry; Nuclear Science & Technology GA DG7LD UT WOS:000372264900035 ER PT J AU Zhang, SS Tran, DT AF Zhang, Sheng S. Tran, Dat T. TI Pyrite FeS2 as an efficient adsorbent of lithium polysulphide for improved lithium-sulphur batteries SO JOURNAL OF MATERIALS CHEMISTRY A LA English DT Article ID LI-S BATTERY; CATHODES; PERFORMANCE; CHEMISTRY; REDOX; GRAPHENE; SURFACE; CELLS; NANOSHEETS; NITROGEN AB Pyrite FeS2 chemically combines lithium polysulphide (Li2Sn) to form active Li2FeS2+n complexes that substantially reduce the out-diffusion of dissolved Li2Sn from sulphur cathodes and consequently improve the cycling performance of lithium-sulphur batteries. The same functions are also applicable to other transition metal sulphides, which opens a new direction for polysulphide sequestration in lithium-sulphur batteries. C1 [Zhang, Sheng S.; Tran, Dat T.] US Army Res Lab, Energy & Power Div, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Zhang, SS (reprint author), US Army Res Lab, Energy & Power Div, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. EM shengshui.zhang.civ@mail.mil RI Zhang, Sheng/A-4456-2012 OI Zhang, Sheng/0000-0003-4435-4110 NR 51 TC 9 Z9 9 U1 54 U2 113 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2050-7488 EI 2050-7496 J9 J MATER CHEM A JI J. Mater. Chem. A PY 2016 VL 4 IS 12 BP 4371 EP 4374 DI 10.1039/c6ta01214k PG 4 WC Chemistry, Physical; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Energy & Fuels; Materials Science GA DG6JQ UT WOS:000372190800004 ER PT J AU Alves, DA Honko, AN Kortepeter, MG Sun, M Johnson, JC Lugo-Roman, LA Hensley, LE AF Alves, Derron A. Honko, Anna N. Kortepeter, Mark G. Sun, Mei Johnson, Joshua C. Lugo-Roman, Luis A. Hensley, Lisa E. TI Necrotizing Scleritis, Conjunctivitis, and Other Pathologic Findings in the Left Eye and Brain of an Ebola Virus-Infected Rhesus Macaque (Macaca mulatta) With Apparent Recovery and a Delayed Time of Death SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE Ebola virus disease; Ebola virus; sequelae; macaque; rhesus; intramuscular; delayed death; eye; brain ID HEMORRHAGIC-FEVER; ZAIRE-EBOLAVIRUS; CONGO; KIKWIT AB A 3.5-year-old adult female rhesus macaque (Macaca mulatta) manifested swelling of the left upper eyelid and conjunctiva and a decline in clinical condition 18 days following intramuscular challenge with Ebola virus (EBOV; Kikwit-1995), after apparent clinical recovery. Histologic lesions with strong EBOV antigen staining were noted in the left eye (scleritis, conjunctivitis, and peri-optic neuritis), brain (choriomeningoencephalitis), stomach, proximal duodenum, and pancreas. Spleen, liver, and adrenal glands, common targets for acute infection, appeared histologically normal with no evidence of EBOV immunoreactivity. These findings may provide important insight for understanding sequelae seen in West African survivors of Ebola virus disease. C1 [Alves, Derron A.] Def Hlth Agcy, Def Hlth Headquarters, Vet Serv, 7700 Arlington Blvd, Falls Church, VA 22042 USA. [Honko, Anna N.; Johnson, Joshua C.; Hensley, Lisa E.] NIAID, Integrated Res Facil, NIH, Ft Detrick, MD USA. [Kortepeter, Mark G.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Sun, Mei] US Army, Med Res Inst Infect Dis, Div Pathol, Ft Detrick, MD 21702 USA. [Lugo-Roman, Luis A.] US Army, Med Res Inst Infect Dis, Vet Med Div, Ft Detrick, MD 21702 USA. RP Alves, DA (reprint author), Def Hlth Agcy, Def Hlth Headquarters, Vet Serv, 7700 Arlington Blvd, Falls Church, VA 22042 USA. EM derron.a.alves.mil@mail.mil OI Honko, Anna/0000-0001-9165-148X FU Defense Threat Reduction Agency [4.10033_07_RD_B] FX This work was supported by the Defense Threat Reduction Agency (project 4.10033_07_RD_B). NR 15 TC 3 Z9 3 U1 0 U2 4 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD JAN 1 PY 2016 VL 213 IS 1 BP 57 EP 60 DI 10.1093/infdis/jiv357 PG 4 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA DF2EG UT WOS:000371152700009 PM 26153408 ER PT S AU Doepker, C Lieberman, HR Smith, AP Peck, JD El-Sohemy, A Welsh, BT AF Doepker, Candace Lieberman, Harris R. Smith, Andrew Paul Peck, Jennifer D. El-Sohemy, Ahmed Welsh, Brian T. BE Doyle, MP Klaenhammer, TR TI Caffeine: Friend or Foe? SO ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 7 SE Annual Review of Food Science and Technology LA English DT Review; Book Chapter DE cardiovascular; pharmacology; reproductive; behavior; benefits; regulation ID CORONARY-HEART-DISEASE; COFFEE CONSUMPTION; MYOCARDIAL-INFARCTION; ENERGY DRINKS; UNITED-STATES; SPONTANEOUS-ABORTION; RISK-FACTORS; CARDIOVASCULAR-DISEASES; EPIDEMIOLOGIC EVIDENCE; ADENOSINE RECEPTORS AB The debate on the safety of and regulatory approaches for caffeine continues among various stakeholders and regulatory authorities. This decision-making process comes with significant challenges, particularly when considering the complexities of the available scientific data, making the formulation of clear science-based regulatory guidance more difficult. To allow for discussions of a number of key issues, the North American Branch of the International Life Sciences Institute (ILSI) convened a panel of subject matter experts for a caffeine-focused session entitled "Caffeine: Friend or Foe?," which was held during the 2015 ILSI Annual Meeting. The panelists' expertise covered topics ranging from the natural occurrence of caffeine in plants and interindividual metabolism of caffeine in humans to specific behavioral, reproductive, and cardiovascular effects related to caffeine consumption. Each presentation highlighted the potential risks, benefits, and challenges that inform whether caffeine exposure warrants concern. This paper aims to summarize the key topics discussed during the session. C1 [Doepker, Candace; Welsh, Brian T.] ToxStrategies Inc, Austin, TX 78759 USA. [Lieberman, Harris R.] US Army Res Inst Environm Med, Natick, MA 01760 USA. [Smith, Andrew Paul] Cardiff Univ, Sch Psychol, Ctr Occupat & Hlth Psychol, Cardiff CF10 3AS, S Glam, Wales. [Peck, Jennifer D.] Univ Oklahoma, Hlth Sci Ctr, Coll Publ Hlth, Dept Biostat & Epidemiol, Oklahoma City, OK 73104 USA. [Smith, Andrew Paul; El-Sohemy, Ahmed] Univ Toronto, Dept Nutr Sci, Toronto, ON M5S 3E2, Canada. RP Doepker, C (reprint author), ToxStrategies Inc, Austin, TX 78759 USA.; Lieberman, HR (reprint author), US Army Res Inst Environm Med, Natick, MA 01760 USA.; Smith, AP (reprint author), Cardiff Univ, Sch Psychol, Ctr Occupat & Hlth Psychol, Cardiff CF10 3AS, S Glam, Wales.; Peck, JD (reprint author), Univ Oklahoma, Hlth Sci Ctr, Coll Publ Hlth, Dept Biostat & Epidemiol, Oklahoma City, OK 73104 USA.; El-Sohemy, A (reprint author), Univ Toronto, Dept Nutr Sci, Toronto, ON M5S 3E2, Canada. EM cdoepker@toxstrategies.com; harris.r.lieberman.civ@mail.mil; smithap@cardiff.ac.uk; jennifer-peck@ouhsc.edu; a.el.sohemy@utoronto.ca NR 141 TC 2 Z9 2 U1 13 U2 63 PU ANNUAL REVIEWS PI PALO ALTO PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0897 USA SN 1941-1413 BN 978-0-8243-4907-3 J9 ANNU REV FOOD SCI T JI Annu. Rev. Food Sci. Technol. PY 2016 VL 7 BP 117 EP 137 DI 10.1146/annurev-food-041715-033243 PG 21 WC Food Science & Technology SC Food Science & Technology GA BE3ZR UT WOS:000371430700006 PM 26735800 ER PT J AU Kotwal, RS Howard, JT Orman, JA Tarpey, BW Bailey, JA Champion, HR Mabry, RL Holcomb, JB Gross, KR AF Kotwal, Russ S. Howard, Jeffrey T. Orman, Jean A. Tarpey, Bruce W. Bailey, Jeffrey A. Champion, Howard R. Mabry, Robert L. Holcomb, John B. Gross, Kirby R. TI The Effect of a Golden Hour Policy on the Morbidity and Mortality of Combat Casualties SO JAMA SURGERY LA English DT Article ID PREHOSPITAL TIME; TRAUMA; CARE; BATTLEFIELD; EVACUATION; INJURY; VIETNAM; IMPACT; DEATH; AFGHANISTAN AB IMPORTANCE The term golden hour was coined to encourage urgency of trauma care. In 2009, Secretary of Defense Robert M. Gates mandated prehospital helicopter transport of critically injured combat casualties in 60 minutes or less. OBJECTIVES To compare morbidity and mortality outcomes for casualties before vs after the mandate and for those who underwent prehospital helicopter transport in 60 minutes or less vs more than 60 minutes. DESIGN, SETTING, AND PARTICIPANTS A retrospective descriptive analysis of battlefield data examined 21 089 US military casualties that occurred during the Afghanistan conflict from September 11, 2001, to March 31, 2014. Analysis was conducted from September 1, 2014, to January 21, 2015. MAIN OUTCOMES AND MEASURES Data for all casualties were analyzed according to whether they occurred before or after the mandate. Detailed data for those who underwent prehospital helicopter transport were analyzed according to whether they occurred before or after the mandate and whether they occurred in 60 minutes or less vs more than 60 minutes. Casualties with minor wounds were excluded. Mortality and morbidity outcomes and treatment capability-related variables were compared. RESULTS For the total casualty population, the percentage killed in action (16.0%[386 of 2411] vs 9.9% [964 of 9755]; P<.001) and the case fatality rate ([CFR] 13.7 [469 of 3429] vs 7.6 [1344 of 17 660]; P<.001) were higher before vs after the mandate, while the percentage died of wounds (4.1%[83 of 2025] vs 4.3%[380 of 8791]; P=.71) remained unchanged. Decline in CFR after the mandate was associated with an increasing percentage of casualties transported in 60 minutes or less (regression coefficient, -0.141; P<.001), with projected vs actual CFR equating to 359 lives saved. Among 4542 casualties (mean injury severity score, 17.3; mortality, 10.1%[457 of 4542]) with detailed data, there was a decrease in median transport time after the mandate (90 min vs 43 min; P<.001) and an increase in missions achieving prehospital helicopter transport in 60 minutes or less (24.8%[181 of 731] vs 75.2% [2867 of 3811]; P<.001). When adjusted for injury severity score and time period, the percentage killed in action was lower for those critically injured who received a blood transfusion (6.8%[40 of 589] vs 51.0% [249 of 488]; P<.001) and were transported in 60 minutes or less (25.7%[205 of 799] vs 30.2%[84 of 278]; P<.01), while the percentage died of wounds was lower among those critically injured initially treated by combat support hospitals (9.1%[48 of 530] vs 15.7%[86 of 547]; P<.01). Acute morbidity was higher among those critically injured who were transported in 60 minutes or less (36.9%[295 of 799] vs 27.3%[76 of 278]; P<.01), those severely and critically injured initially treated at combat support hospitals (severely injured, 51.1% [161 of 315] vs 33.1%[104 of 314]; P<.001; and critically injured, 39.8%[211 of 530] vs 29.3%[160 of 547]; P<.001), and casualties who received a blood transfusion (50.2%[618 of 1231] vs 3.7%[121 of 3311]; P<.001), emphasizing the need for timely advanced treatment. CONCLUSIONS AND RELEVANCE A mandate made in 2009 by Secretary of Defense Gates reduced the time between combat injury and receiving definitive care. Prehospital transport time and treatment capability are important factors for casualty survival on the battlefield. C1 [Kotwal, Russ S.; Howard, Jeffrey T.; Orman, Jean A.; Tarpey, Bruce W.; Bailey, Jeffrey A.; Mabry, Robert L.; Gross, Kirby R.] US Army Inst Surg Res, Joint Trauma Syst, 3698 Chambers Pass, Joint Base San Antonio F, TX 78234 USA. [Kotwal, Russ S.; Bailey, Jeffrey A.; Champion, Howard R.; Gross, Kirby R.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Kotwal, Russ S.] Texas A&M Hlth Sci Ctr, Coll Med, College Stn, TX USA. [Holcomb, John B.] Univ Texas Med Sch, Ctr Translat Injury Res, Houston, TX USA. RP Kotwal, RS (reprint author), US Army Inst Surg Res, Joint Trauma Syst, 3698 Chambers Pass, Joint Base San Antonio F, TX 78234 USA. EM russ.kotwal@us.army.mil NR 43 TC 13 Z9 14 U1 3 U2 11 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6254 EI 2168-6262 J9 JAMA SURG JI JAMA Surg. PD JAN PY 2016 VL 151 IS 1 BP 15 EP 24 DI 10.1001/jamasurg.2015.3104 PG 10 WC Surgery SC Surgery GA DF4KD UT WOS:000371315800005 PM 26422778 ER PT J AU Rasmussen, TE AF Rasmussen, Todd E. TI The Power of Advanced Capability and Informed Policy SO JAMA SURGERY LA English DT Editorial Material C1 [Rasmussen, Todd E.] US Army, US Combat Casualty Care Res Program, 722 Doughten St,Room 3, Ft Detrick, MD 21702 USA. [Rasmussen, Todd E.] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, Bethesda, MD 20814 USA. RP Rasmussen, TE (reprint author), US Army, US Combat Casualty Care Res Program, 722 Doughten St,Room 3, Ft Detrick, MD 21702 USA. EM todd.e.rasmussen.mil@mail.mil NR 5 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6254 EI 2168-6262 J9 JAMA SURG JI JAMA Surg. PD JAN PY 2016 VL 151 IS 1 BP 25 EP 25 DI 10.1001/jamasurg.2015.3111 PG 1 WC Surgery SC Surgery GA DF4KD UT WOS:000371315800006 PM 26422056 ER PT J AU Yan, T Li, ZH Li, YZ Qin, H AF Yan, Ting Li, Zhaohai Li, Yuanzhang Qin, Hong TI Likelihood ratio tests in the Rasch model for item response data when the number of persons and items goes to infinity SO STATISTICS AND ITS INTERFACE LA English DT Article DE Fisher information matrix; Likelihood ratio tests; Rasch model; Wilks type of results ID RANDOM-VARIABLES; RANDOM GRAPHS AB When the number of persons and items goes to infinity simultaneously, the maximum likelihood estimator in the Rasch model for dichotomous item response data has been shown to be consistency and asymptotic normality. However, the limiting distributions of the likelihood ratio tests in the past thirty years are still unknown. In this paper, we establish the Wilks type of results for the likelihood ratio tests under some simple and composite null hypotheses. Our proof crucially depends on the approximated inverse of the Fisher information matrix with small approximation errors. Simulation studies are provided to illustrate the asymptotic results. C1 [Yan, Ting; Qin, Hong] Cent China Normal Univ, Dept Stat, Wuhan 430079, Peoples R China. [Li, Zhaohai] George Washington Univ, Dept Stat, 2140 Penn Ave NW, Washington, DC 20052 USA. [Li, Yuanzhang] Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. RP Yan, T (reprint author), Cent China Normal Univ, Dept Stat, Wuhan 430079, Peoples R China. EM tingyanty@mail.ccnu.edu.cn; zli@gwu.edu; Liy.Li@us.army.mil; qinhong@mail.ccnu.edu.cn FU National Natural Science Foundation of China [11401239]; Postdoctoral Science Foundation of China [2014M552064] FX Yan's research was partially supported by the National Natural Science Foundation of China (No. 11401239) and Postdoctoral Science Foundation of China (No. 2014M552064). NR 28 TC 0 Z9 0 U1 1 U2 1 PU INT PRESS BOSTON, INC PI SOMERVILLE PA PO BOX 43502, SOMERVILLE, MA 02143 USA SN 1938-7989 EI 1938-7997 J9 STAT INTERFACE JI Stat. Interface PY 2016 VL 9 IS 2 BP 223 EP 232 PG 10 WC Mathematical & Computational Biology; Mathematics, Interdisciplinary Applications SC Mathematical & Computational Biology; Mathematics GA DF2RX UT WOS:000371192600009 ER PT J AU Taylor, D Bright, JA McGoven, C Hefford, C Kalafut, T Buckleton, J AF Taylor, Duncan Bright, Jo-Anne McGoven, Catherine Hefford, Christopher Kalafut, Tim Buckleton, John TI Validating multiplexes for use in conjunction with modern interpretation strategies SO FORENSIC SCIENCE INTERNATIONAL-GENETICS LA English DT Article DE Forensic DNA interpretation; GlobalFiler; Continuous DNA interpretation; STRmix; Modelling; DNA mixtures ID ALLELIC DROP-OUT; FORENSIC DNA PROFILES; MIXTURE INTERPRETATION; LOGISTIC-REGRESSION; STATISTICAL-MODEL; STR MULTIPLEXES; STUTTER; PROBABILITIES; LOCI; PERFORMANCE AB In response to requests from the forensic community, commercial companies are generating larger, more sensitive, and more discriminating STR multiplexes. These multiplexes are now applied to a wider range of samples including complex multi-person mixtures. In parallel there is an overdue reappraisal of profile interpretation methodology. Aspects of this reappraisal include 1. The need for a quantitative understanding of allele and stutter peak heights and their variability, 2. An interest in reassessing the utility of smaller peaks below the often used analytical threshold, 3. A need to understand not just the occurrence of peak drop-in but also the height distribution of such peaks, and 4. A need to understand the limitations of the multiplex-interpretation strategy pair implemented. In this work we present a full scheme for validation of a new multiplex that is suitable for informing modern interpretation practice. We predominantly use GlobalFiler (TM) as an example multiplex but we suggest that the aspects investigated here are fundamental to introducing any multiplex in the modern interpretation environment. (C) 2015 Elsevier Ireland Ltd. All rights reserved. C1 [Taylor, Duncan; Hefford, Christopher] Forens Sci South Australia, 21 Divett Pl, Adelaide, SA 5000, Australia. [Taylor, Duncan] Flinders Univ S Australia, Sch Biol Sci, GPO Box 2100, Adelaide, SA 5001, Australia. [Bright, Jo-Anne; McGoven, Catherine; Buckleton, John] Inst Environm Sci & Res Ltd, Private Bag 92021, Auckland 1142, New Zealand. [Kalafut, Tim] US Army, Criminal Investigat Lab, Def Forens Sci Ctr, Forest Pk, GA 30297 USA. RP Taylor, D (reprint author), Forens Sci South Australia, 21 Divett Pl, Adelaide, SA 5000, Australia. EM Duncan.Taylor@sa.gov.au OI Taylor, Duncan/0000-0003-0633-7424 FU US National Institute of Justice [2011-DN-BX-K541] FX This work was supported in part by grant 2011-DN-BX-K541 from the US National Institute of Justice. Points of view in this document are those of the authors and do not necessarily represent the official position or policies of the U.S. Department of Justice or the Departments of Defense and Army. Names of commercial manufacturers or products included are incidental only, and inclusion does not imply endorsement by the Departments of Defense. NR 47 TC 6 Z9 6 U1 7 U2 11 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 1872-4973 EI 1878-0326 J9 FORENSIC SCI INT-GEN JI Forensic Sci. Int.-Genet. PD JAN PY 2016 VL 20 BP 6 EP 19 DI 10.1016/j.fsigen.2015.09.011 PG 14 WC Genetics & Heredity; Medicine, Legal SC Genetics & Heredity; Legal Medicine GA DE7IY UT WOS:000370810600006 PM 26433484 ER PT J AU Zhang, SS Tran, DT AF Zhang, Sheng S. Tran, Dat T. TI Mechanism and Solution for the Capacity Fading of Li/FeS2 Battery SO JOURNAL OF THE ELECTROCHEMICAL SOCIETY LA English DT Article ID LITHIUM-ION BATTERIES; REDUCED GRAPHENE OXIDE; CATHODE MATERIAL; PYRITE FES2; ELECTROCHEMICAL CHARACTERISTICS; POLYMER ELECTROLYTE; ROOM-TEMPERATURE; ANODE MATERIALS; NATURAL PYRITE; SOLID-STATE AB Development of Li/FeS2 rechargeable batteries has been hampered by their short cycle life. In this paper, we start with the fundamental chemistry of FeS2 in a non-aqueous liquid electrolyte to analyze the capacity fading mechanism of Li/FeS2 batteries and propose three facile strategies for stabilizing capacity. It is repeatedly observed that the capacity fading of Li/FeS2 cells follows a general mode consisting of a fast fading stage as Region 1, a slow fading stage as Region 2, and an accelerated fading stage as Region 3. We found that Region 1 is mainly attributed to the dissolution of lithium polysulfide leading to the loss of sulfur active material, and that Region 3 is mainly associated with the poor morphology of Li deposition resulting in the localized electric circuit shortening. The powder-like, small and loose Li particles not only react with electrolyte solvents drying-out the cell but also penetrate across the separator shortening the cell. Based on the above finding, the cycle life of Li/FeS2 cells was improved by adding vinylene carbonate as the electrolyte additive, increasing mechanical pressure between two electrodes, and placing a carbon interlayer between the FeS2 cathode and separator, respectively. (C) The Author(s) 2016. Published by ECS. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License (CC BY, http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse of the work in any medium, provided the original work is properly cited. All rights reserved. C1 [Zhang, Sheng S.; Tran, Dat T.] US Army, Res Lab, Electrochem Branch, RDRL SED C,Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. RP Zhang, SS (reprint author), US Army, Res Lab, Electrochem Branch, RDRL SED C,Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. EM shengshui.zhang.civ@mail.mil RI Zhang, Sheng/A-4456-2012 OI Zhang, Sheng/0000-0003-4435-4110 NR 51 TC 5 Z9 5 U1 25 U2 70 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 65 SOUTH MAIN STREET, PENNINGTON, NJ 08534 USA SN 0013-4651 EI 1945-7111 J9 J ELECTROCHEM SOC JI J. Electrochem. Soc. PY 2016 VL 163 IS 5 BP A792 EP A797 DI 10.1149/2.0041606jes PG 6 WC Electrochemistry; Materials Science, Coatings & Films SC Electrochemistry; Materials Science GA DE8DT UT WOS:000370866700029 ER PT J AU Kaspar, RB Wittkopf, JA Woodroof, MD Armstrong, MJ Yan, YS AF Kaspar, Robert B. Wittkopf, Jarrid A. Woodroof, Mariah D. Armstrong, Matthew J. Yan, Yushan TI Reverse-Current Decay in Hydroxide Exchange Membrane Fuel Cells SO JOURNAL OF THE ELECTROCHEMICAL SOCIETY LA English DT Article ID OXYGEN REDUCTION; CARBON CORROSION; ELECTRODE; CATALYSTS; KINETICS; WATER AB In proton exchange membrane fuel cells (PEMFCs), the cathode carbon support corrodes during startup and shutdown by reverse-current decay (RCD). We show for the first time that hydroxide exchange membrane fuel cells (HEMFCs) also undergo RCD. We find that decreasing the oxygen reduction reaction (ORR) activity of the anode catalyst mitigates RCD: a Ru anode causes less corrosion than Pt, Ir, and Pd anodes, as expected from their ORR activities. After an intensive 6 h RCD test, an HEMFC based on Ru shows six times lower internal resistance compared to Pt (1.02 vs. 6.01 Omega cm(2)). Due to its enhanced ORR activity in base, carbon alone can sustain RCD. To minimize RCD the carbon support should be eliminated from the anode catalyst. (C) The Author(s) 2016. Published by ECS. All rights reserved. C1 [Kaspar, Robert B.; Wittkopf, Jarrid A.; Woodroof, Mariah D.; Yan, Yushan] Univ Delaware, Ctr Catalyt Sci & Technol, Dept Biomol & Chem Engn, Newark, DE 19716 USA. [Armstrong, Matthew J.] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. RP Yan, YS (reprint author), Univ Delaware, Ctr Catalyt Sci & Technol, Dept Biomol & Chem Engn, Newark, DE 19716 USA. EM yanys@udel.edu FU Advanced Research Projects Agency-Energy (ARPA-E) [DE-AR0000009] FX This work was supported in part by the Advanced Research Projects Agency-Energy (ARPA-E) under award number DE-AR0000009. The authors thank A. N. Beris for assistance with the computational modeling. NR 26 TC 2 Z9 2 U1 6 U2 13 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 65 SOUTH MAIN STREET, PENNINGTON, NJ 08534 USA SN 0013-4651 EI 1945-7111 J9 J ELECTROCHEM SOC JI J. Electrochem. Soc. PY 2016 VL 163 IS 5 BP F377 EP F383 DI 10.1149/2.041605jes PG 7 WC Electrochemistry; Materials Science, Coatings & Films SC Electrochemistry; Materials Science GA DE8DT UT WOS:000370866700087 ER PT J AU Tomaiuolo, M Kottke, M Matheny, RW Reifman, J Mitrophanov, AY AF Tomaiuolo, Maurizio Kottke, Melissa Matheny, Ronald W., Jr. Reifman, Jaques Mitrophanov, Alexander Y. TI Computational identification and analysis of signaling subnetworks with distinct functional roles in the regulation of TNF production SO MOLECULAR BIOSYSTEMS LA English DT Article ID NF-KAPPA-B; TUMOR-NECROSIS-FACTOR; TOLL-LIKE RECEPTOR; NEGATIVE REGULATOR; TEMPORAL CONTROL; IL-10 PRODUCTION; GENE-EXPRESSION; ANTIINFLAMMATORY RESPONSE; MOLECULAR-MECHANISMS; CHRONIC INFLAMMATION AB Inflammation is a complex process driven by the coordinated action of a vast number of pro- and anti-inflammatory molecular mediators. While experimental studies have provided an abundance of information about the properties and mechanisms of action of individual mediators, essential system-level regulatory patterns that determine the time-course of inflammation are not sufficiently understood. In particular, it is not known how the contributions from distinct signaling pathways involved in cytokine regulation combine to shape the overall inflammatory response over different time scales. We investigated the kinetics of the intra- and extracellular signaling network controlling the production of the essential pro- inflammatory cytokine, tumor necrosis factor (TNF), and its anti-inflammatory counterpart, interleukin 10 (IL-10), in a macrophage culture. To tackle the intrinsic complexity of the network, we employed a computational modeling approach using the available literature data about specific molecular interactions. Our computational model successfully captured experimentally observed short- and long-term kinetics of key inflammatory mediators. Subsequent model analysis showed that distinct subnetworks regulate IL-10 production by impacting different temporal phases of the cAMP response element-binding protein (CREB) phosphorylation. Moreover, the model revealed that functionally similar inhibitory control circuits regulate the early and late activation phases of nuclear factor kappa B and CREB. Finally, we identified and investigated distinct signaling subnetworks that independently control the peak height and tail height of the TNF temporal trajectories. The knowledge of such subnetwork-specific regulatory effects may facilitate therapeutic interventions aimed at precise modulation of the inflammatory response. C1 [Tomaiuolo, Maurizio; Reifman, Jaques; Mitrophanov, Alexander Y.] US Army Med Res & Mat Command, High Performance Comp Software Applicat Inst, Telemed & Adv Technol Res Ctr, Dept Def Biotechnol,ATTN MCMR TT, 504 Scott St, Ft Detrick, MD USA. [Kottke, Melissa; Matheny, Ronald W., Jr.] US Army Res Inst Environm Med, Mil Performance Div, 15 Kansas St,Bldg 42, Natick, MA 01760 USA. RP Reifman, J (reprint author), US Army Med Res & Mat Command, High Performance Comp Software Applicat Inst, Telemed & Adv Technol Res Ctr, Dept Def Biotechnol,ATTN MCMR TT, 504 Scott St, Ft Detrick, MD USA. EM jaques.reifman.civ@mail.mil FU Military Operational Medicine Research Program of U.S. Army Medical Research and Materiel Command, Fort Detrick, MD FX The authors are grateful to Dr Sridevi Nagaraja for her assistance with global sensitivity analysis and to three anonymous reviewers for their comments on an earlier version of the paper. This work was supported by the Military Operational Medicine Research Program of the U.S. Army Medical Research and Materiel Command, Fort Detrick, MD. NR 83 TC 1 Z9 1 U1 0 U2 0 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1742-206X EI 1742-2051 J9 MOL BIOSYST JI Mol. Biosyst. PY 2016 VL 12 IS 3 BP 826 EP 838 DI 10.1039/c5mb00456j PG 13 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA DF0OX UT WOS:000371039800015 PM 26751842 ER PT J AU Auysawasdi, N Chuntranuluck, S Phasomkusolsil, S Keeratinijakal, V AF Auysawasdi, Nutthanun Chuntranuluck, Sawitri Phasomkusolsil, Siriporn Keeratinijakal, Vichien TI Improving the effectiveness of three essential oils against Aedes aegypti (Linn.) and Anopheles dirus (Peyton and Harrison) SO PARASITOLOGY RESEARCH LA English DT Article DE Essential oil; Repellent; Protection time; Aedes aegypti; Anopheles dirus ID REPELLENT ACTIVITY; INSECT REPELLENTS; MOSQUITOS; LEAF; CONSTITUENTS; FORMULATION; TOXICITY; VANILLIN; DEET; L. AB Repellency of essential oil extracted from Curcuma longa, Eucalyptus globulus, and Citrus aurantium at various concentrations (5, 10, 15, 20, and 25 %) with and without 5 % vanillin was evaluated against female mosquitoes: Aedes aegypti and Anopheles dirus. The comparisons were made with a commercial chemical repellent (N,N-diethyl-3-methylbenzamide (DEET) 25 % w/w; KOR YOR 15) by arm in cage method. It was found that the essential oils with 5 % vanillin gave the longest lasting period against two mosquitoes as follows: Curcuma longa gave 150 min for Ae. aegypti, 480 min for An. dirus; Eucalyptus globulus gave 144 min for Ae. aegypti, 390 min for An. dirus; and Citrus aurantium gave 120 min for Ae. aegypti, 360 min for An. dirus. The 25 % Curcuma longa essential oil exhibited the best efficiency as equal as a commercial repellent (480 min against An. dirus). Vanillin can extend the period of time in protection against the two mosquitoes. This study indicates the potential uses of the essential oils (Curcuma longa, Eucalyptus globulus, and Citrus aurantium) with vanillin as natural mosquito repellents. C1 [Auysawasdi, Nutthanun; Chuntranuluck, Sawitri] Kasetsart Univ, Fac Agroind, Dept Biotechnol, 50 Ngam Wong Wan Rd, Bangkok 10900, Thailand. [Keeratinijakal, Vichien] Kasetsart Univ, Fac Agr, Dept Agron, 50 Ngam Wong Wan Rd, Bangkok 10900, Thailand. [Phasomkusolsil, Siriporn] Armed Forces Res Inst Med Sci, US Army Med Component, Dept Entomol, Bangkok 10400, Thailand. RP Auysawasdi, N (reprint author), Kasetsart Univ, Fac Agroind, Dept Biotechnol, 50 Ngam Wong Wan Rd, Bangkok 10900, Thailand. EM zheezelz@gmail.com NR 26 TC 3 Z9 3 U1 5 U2 20 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0932-0113 EI 1432-1955 J9 PARASITOL RES JI Parasitol. Res. PD JAN PY 2016 VL 115 IS 1 BP 99 EP 106 DI 10.1007/s00436-015-4725-3 PG 8 WC Parasitology SC Parasitology GA DE8EM UT WOS:000370868600010 PM 26358103 ER PT B AU Bottoni, CR Krul, KP AF Bottoni, Craig R. Krul, Kevin P. BE Ryu, RKN Angelo, RL Abrams, JS TI Arthroscopic Acromioclavicular Joint Repair for Acute Injury SO SHOULDERS: AANA ADVANCED ARTHROSCOPIC SURGICAL TECHNIQUES LA English DT Article; Book Chapter ID DISLOCATIONS; SEPARATIONS; MANAGEMENT; DIAGNOSIS; RELIABILITY C1 [Bottoni, Craig R.] Tripler Army Med Ctr, Sports Med, Honolulu, HI 96859 USA. [Bottoni, Craig R.] Tripler Army Med Ctr, Orthopaed Surg Serv, Residency Res, Honolulu, HI 96859 USA. [Krul, Kevin P.] Tripler Army Med Ctr, Orthopaed Surg Serv, Honolulu, HI 96859 USA. RP Bottoni, CR (reprint author), Tripler Army Med Ctr, Sports Med, Honolulu, HI 96859 USA. NR 21 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE ROAD, THOROFARE, NJ 08086-9447 USA BN 978-1-63091-002-0 PY 2016 BP 71 EP 80 PG 10 WC Surgery SC Surgery GA BE1BX UT WOS:000367697500007 ER PT B AU Warner, JJP Dilisio, MF Parada, SA AF Warner, Jon J. P. Dilisio, Matthew F. Parada, Stephen A. BE Ryu, RKN Angelo, RL Abrams, JS TI Arthroscopic Panlabral Repair SO SHOULDERS: AANA ADVANCED ARTHROSCOPIC SURGICAL TECHNIQUES LA English DT Article; Book Chapter ID ANTERIOR SHOULDER INSTABILITY; SUPERIOR LABRAL ANTERIOR; GLENOID LABRUM; CIRCUMFERENTIAL LESIONS; POSTERIOR LESIONS; AMERICAN BOARD; BANKART REPAIR; SLAP LESIONS; OUTCOMES; MANAGEMENT C1 [Warner, Jon J. P.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston Shoulder Inst, Boston, MA USA. [Dilisio, Matthew F.] Creighton Univ, Orthopaed CHI Hlth Shoulder Ctr, Orthopaed Surg, Omaha, NE 68178 USA. [Parada, Stephen A.] Eisenhower Army Med Ctr, Shoulder Surg, Ft Gordon, GA USA. [Parada, Stephen A.] Eisenhower Army Med Ctr, Ft Gordon, GA USA. [Parada, Stephen A.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Warner, JJP (reprint author), Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston Shoulder Inst, Boston, MA USA. NR 27 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE ROAD, THOROFARE, NJ 08086-9447 USA BN 978-1-63091-002-0 PY 2016 BP 285 EP 295 PG 11 WC Surgery SC Surgery GA BE1BX UT WOS:000367697500024 ER PT J AU Herbst, S AF Herbst, Seth TI Milton and Music SO ESSAYS IN CRITICISM LA English DT Article C1 [Herbst, Seth] US Mil Acad, West Point, NY 10996 USA. RP Herbst, S (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 8 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0014-0856 EI 1471-6852 J9 ESSAYS CRITICISM JI Essays Critic. PD JAN PY 2016 VL 66 IS 1 BP 96 EP 116 DI 10.1093/escrit/cgv031 PG 21 WC Literature SC Literature GA DD8FQ UT WOS:000370161300005 ER PT J AU Arcone, SA Grant, SA Boitnott, GE AF Arcone, Steven A. Grant, Steven A. Boitnott, Ginger E. TI Maxwell-Wagner Relaxation in Two Desert Soils at Medium and High Water Contents: Interpretation From Modeling of Time Domain Reflectometry Data SO IEEE JOURNAL OF SELECTED TOPICS IN APPLIED EARTH OBSERVATIONS AND REMOTE SENSING LA English DT Article DE Dielectric permittivity; electrode polarization (EP); induced polarization (IP); Maxwell-Wagner; soils ID BAND DIELECTRIC-SPECTROSCOPY; COMPLEX PERMITTIVITY; POLARIZATION AB Maxwell-Wagner relaxations (MWRs) are generally between 1 and 20 MHz in fine grain soils at volumetric water contents less than 10%. Isolated water inclusions appear to cause MWR. We used time domain reflectometry to measure complex permittivity from 6 kHz to 6 GHz of two, quartz-rich desert soils to test if MWR occur at a limited number of higher water contents because inclusion concentration should then decrease. One soil had lesser calcite; the other lesser gypsum. Water contents ranged from 6.2% to 33.8%. Unwanted electrode polarization (EP) dominates the real part of permittivity below 1 MHz. We interpreted MWR from complex refractive index models (CRIMs) that summed expressions for EP, Debye-type MWR, free water relaxation (FWR), and air volume. Broadband MWRs centered from 1 to 36 MHz exist up to 17% volumetric water contents and up to 196 MHz in the quartz-gypsum soil at saturation, with small to significant Cole-Cole factors that suggest a range of relaxation processes, and attenuation rates that increase to nearly 100 dBm(-1) as frequency increased across the 100-1000 MHz GPR bandwidth. The Cole-Cole factor generally decreased with increasing relaxation frequency, while inclusion conductivity, derived from relaxation frequency, generally increased with increasing bulk conductivity and water content. These results suggest inclusion concentration and a spectrum of their conductivity values decreased, while ionicmobility increased. At saturation, the quartz-calcite soil provided an unexpected low relaxation frequency of 1.28 MHz, possibly caused by inclusions retained within calcite growths upon quartz grains, and within minor amount of smectite. C1 [Arcone, Steven A.; Grant, Steven A.; Boitnott, Ginger E.] US Army ERDC CRREL, Hanover, NH 03755 USA. RP Arcone, SA (reprint author), US Army ERDC CRREL, Hanover, NH 03755 USA. EM Steven.A.Arcone@erdc.dren.mil FU US Army Engineer and Research Development Center 6.1 program in basic research FX This work was supported by the US Army Engineer and Research Development Center 6.1 program in basic research. NR 25 TC 0 Z9 0 U1 2 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1939-1404 EI 2151-1535 J9 IEEE J-STARS JI IEEE J. Sel. Top. Appl. Earth Observ. Remote Sens. PD JAN PY 2016 VL 9 IS 1 BP 201 EP 211 DI 10.1109/JSTARS.2015.2436822 PG 11 WC Engineering, Electrical & Electronic; Geography, Physical; Remote Sensing; Imaging Science & Photographic Technology SC Engineering; Physical Geography; Remote Sensing; Imaging Science & Photographic Technology GA DE3PE UT WOS:000370541400022 ER PT J AU Zaghi, S Holty, JEC Certal, V Abdullatif, J Guilleminault, C Powell, NB Riley, RW Camacho, M AF Zaghi, Soroush Holty, Jon-Erik C. Certal, Victor Abdullatif, Jose Guilleminault, Christian Powell, Nelson B. Riley, Robert W. Camacho, Macario TI Maxillomandibular Advancement for Treatment of Obstructive Sleep Apnea A Meta-analysis SO JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY LA English DT Article ID POSITIVE AIRWAY PRESSURE; MAXILLOFACIAL SURGERY; SURGICAL-TREATMENT; CONSECUTIVE PATIENTS; COMPUTED-TOMOGRAPHY; REDEFINING SUCCESS; HYOID ADVANCEMENT; ORAL APPLIANCES; MANAGEMENT; MAXILLARY AB IMPORTANCE Maxillomandibular advancement (MMA) is an invasive yet effective surgical option for obstructive sleep apnea (OSA) that achieves enlargement of the upper airway by physically expanding the facial skeletal framework. OBJECTIVE To identify criteria associated with surgical outcomes of MMA using aggregated individual patient data from multiple studies. DATA SOURCES The Cochrane Library, Scopus, Web of Science, and MEDLINE from June 1, 2014, to March 16, 2015, using the Medical Subject Heading keywords maxillomandibular advancement, orthognathic surgery, maxillary osteotomy, mandibular advancement, sleep apnea, surgical, surgery, sleep apnea syndrome, and obstructive sleep apnea. STUDY SELECTION Inclusion criteria consisted of studies in all languages of (1) adult patients who underwent MMA as treatment for OSA; (2) report of preoperative and postoperative quantitative outcomes for the apnea-hypopnea index (AHI) and/or respiratory disturbance index (RDI); and (3) report of individual patient data. Studies of patients who underwent adjunctive procedures at the time of MMA (including tonsillectomy, uvulopalatopharyngoplasty, and partial glossectomy) were excluded. DATA EXTRACTION Three coauthors systematically reviewed the articles and updated the review through March 16, 2015. The PRISMA statement was followed. Data were pooled using a random-effects model and analyzed from July 1, 2014, to September 23, 2015. MAIN OUTCOMES AND MEASURES The primary outcomes were changes in the AHI and RDI after MMA for each patient. Secondary outcomes included surgical success, defined as the percentage of patients with more than 50% reduction of the AHI to fewer than 20 events/h, and OSA cure, defined as a post-MMA AHI of fewer than 5 events/h. RESULTS Forty-five studies with individual data from 518 unique patients/interventions were included. Among patients for whom data were available, 197 of 268 (73.5%) had undergone prior surgery for OSA. Mean (SD) postoperative changes in the AHI and RDI after MMA were -47.8 (25.0) and -44.4 (33.0), respectively; mean (SE) reductions of AHI and RDI outcomes were 80.1% (1.8%) and 64.6% (4.0%), respectively; and 512 of 518 patients (98.8%) showed improvement. Significant improvements were also seen in the mean (SD) postoperative oxygen saturation nadir (70.1% [15.6%] to 87.0% [5.2%]; P < .001) and Epworth Sleepiness Scale score (13.5 [5.2] to 3.2 [3.2]; P < .001). Rates of surgical success and cure were 389 (85.5%) and 175 (38.5%), respectively, among 455 patients with AHI data and 44 (64.7%) and 13 (19.1%), respectively, among 68 patients with RDI data. Preoperative AHI of fewer than 60 events/h was the factor most strongly associated with the highest incidence of surgical cure. Nevertheless, patients with a preoperative AHI of more than 60 events/h experienced large and substantial net improvements despite modest surgical cure rates. CONCLUSIONS AND RELEVANCE Maxillomandibular advancement is an effective treatment for OSA. Most patients with high residual AHI and RDI after other unsuccessful surgical procedures for OSA are likely to benefit from MMA. C1 [Zaghi, Soroush] Univ Calif Los Angeles, David Geffen Sch Med, Dept Head & Neck Surg, 10833 LeConte Ave,Room 62-132, Los Angeles, CA 90095 USA. [Holty, Jon-Erik C.] Stanford Univ, Vet Affairs Palo Hlth Care Syst, Dept Med, Pulm Crit Care & Sleep Med Sect,Pulm Div, Palo Alto, CA 94304 USA. [Certal, Victor] Hosp CUF Porto, Dept Otorhinolaryngol, Sleep Med Ctr, Oporto, Portugal. [Certal, Victor] Univ Porto, Ctr Res Hlth Technol & Informat Syst, Rua Campo Alegre 823, P-4100 Oporto, Portugal. [Abdullatif, Jose] Hosp Bernardino Rivadavia, Dept Otorhinolaryngol, Buenos Aires, DF, Argentina. [Guilleminault, Christian; Camacho, Macario] Stanford Hosp & Clin, Dept Psychiat & Behav Sci, Sleep Med Div, Redwood City, CA USA. [Powell, Nelson B.; Riley, Robert W.] Stanford Hosp & Clin, Sleep Surg Div, Dept Otolaryngol Head & Neck Surg, Redwood City, CA USA. [Camacho, Macario] Tripler Army Med Ctr, Div Sleep Surg & Med, Dept Otolaryngol Head & Neck Surg, Honolulu, HI 96859 USA. RP Zaghi, S (reprint author), Univ Calif Los Angeles, David Geffen Sch Med, Dept Head & Neck Surg, Ctr Hlth Sci, 10833 LeConte Ave,Room 62-132, Los Angeles, CA 90095 USA. EM soroush.zaghi@gmail.com NR 68 TC 5 Z9 5 U1 2 U2 6 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6181 EI 2168-619X J9 JAMA OTOLARYNGOL JI JAMA Otolaryngol-Head Neck Surg. PD JAN PY 2016 VL 142 IS 1 BP 58 EP 66 DI 10.1001/jamaoto.2015.2678 PG 9 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA DE5RN UT WOS:000370689500010 PM 26606321 ER PT J AU Maule, AL Proctor, SP Blount, BC Chambers, DM McClean, MD AF Maule, Alexis L. Proctor, Susan P. Blount, Benjamin C. Chambers, David M. McClean, Michael D. TI Volatile Organic Compounds in Blood as Biomarkers of Exposure to JP-8 Jet Fuel Among US Air Force Personnel SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID INHALATION EXPOSURE; URINARY BIOMARKERS; DERMAL EXPOSURE; POPULATION; SMOKING; JP8 AB Objective: This study aimed to evaluate blood volatile organic compound (VOC) levels as biomarkers of occupational jet propulsion fuel 8 (JP-8) exposure while controlling for smoking. Methods: Among 69 Air Force personnel, post-shift blood samples were analyzed for components of JP-8, including ethylbenzene, toluene, o-xylene, and m/p-xylene, and for the smoking biomarker, 2,5-dimethylfuran. JP-8 exposure was characterized based on self-report and measured work shift levels of total hydrocarbons in personal air. Multivariate regression was used to evaluate the relationship between JP-8 exposure and post-shift blood VOCs while controlling for potential confounding from smoking. Results: Blood VOC concentrations were higher among US Air Force personnel who reported JP-8 exposure and work shift smoking. Breathing zone total hydrocarbons was a significant predictor of VOC blood levels, after controlling for smoking. Conclusions: These findings support the use of blood VOCs as a biomarker of occupational JP-8 exposure. C1 [Maule, Alexis L.; Proctor, Susan P.; McClean, Michael D.] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Natick, MA USA. [Maule, Alexis L.; Proctor, Susan P.] US Army, Environm Med Res Inst, Div Mil Performance, 10 Gen Greene Ave,Bldg 42, Natick, MA 01760 USA. [Proctor, Susan P.] Vet Affairs Boston Healthcare Syst, Boston, MA USA. [Blount, Benjamin C.; Chambers, David M.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA. RP Maule, AL (reprint author), US Army, Environm Med Res Inst, Div Mil Performance, 10 Gen Greene Ave,Bldg 42, Natick, MA 01760 USA. EM alexis.l.maule.ctr@mail.mil FU US Army Medical Research and Materiel Command [W81XWH-06-1-0105] FX This work was supported by the US Army Medical Research and Materiel Command through a grant award (W81XWH-06-1-0105; principal investigator: SPP) to the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. NR 25 TC 0 Z9 0 U1 1 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1076-2752 EI 1536-5948 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD JAN PY 2016 VL 58 IS 1 BP 24 EP 29 DI 10.1097/JOM.0000000000000611 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA DD8VC UT WOS:000370204000005 PM 26716845 ER PT J AU Rinella, ME Lominadze, Z Loomba, R Charlton, M Neuschwander-Tetri, BA Caldwell, SH Kowdley, K Harrison, SA AF Rinella, Mary E. Lominadze, Zurabi Loomba, Rohit Charlton, Michael Neuschwander-Tetri, Brent A. Caldwell, Stephen H. Kowdley, Kris Harrison, Stephen A. TI Practice patterns in NAFLD and NASH: real life differs from published guidelines SO THERAPEUTIC ADVANCES IN GASTROENTEROLOGY LA English DT Article DE liver biopsy; nonalcoholic fatty liver disease; nonalcoholic steatohepatitis; pioglitazone; practice guidelines; practice patterns; diagnosis; treatment ID FATTY LIVER-DISEASE; VITAMIN-E SUPPLEMENTATION; RANDOMIZED CONTROLLED-TRIALS; BARIATRIC SURGERY; NONALCOHOLIC STEATOHEPATITIS; HEPATOCELLULAR-CARCINOMA; CANCER PREVENTION; DIABETIC-PATIENTS; GASTRIC BYPASS; HEART-FAILURE AB Background: Management guidelines from the American Association for the Study of Liver Diseases/American College of Gastroenterology/American Gastroenterology Association published in 2012 for nonalcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) recommend weight loss, vitamin E and pioglitazone as effective therapies for the treatment of biopsy-confirmed NASH. However, little is known about how physicians in the US diagnose NASH or whether published guidelines are being followed. Methods: We assessed current diagnostic and treatment patterns of the management of NAFLD and NASH among academic gastroenterologists and hepatologists in the US using a standardized survey developed to collect information regarding respondents' practice environments, diagnostic techniques, and medication usage in patients with NAFLD/NASH. Results: We invited 482 gastroenterologists and hepatologists, predominantly from academic centers, of whom 163 completed the survey. Only 24% of providers routinely perform liver biopsy, predominantly among patients with elevated serum aminotransferases. Vitamin E is prescribed regularly by 70% while only 14% routinely prescribe pioglitazone. Despite recommendations to the contrary, similar to 25% prescribe pioglitazone or vitamin E without biopsy confirmation of NASH. Metformin is used as frequently as pioglitazone despite its proven lack of efficacy in NASH. Overall, 40-73% adhere to published guidelines, depending on the specific question. There was no significant difference seen in adherence to guidelines between gastroenterologists and hepatologists. Conclusion: This survey suggests that clinical practice patterns among gastroenterologists and hepatologists for the management of NASH frequently diverge from published practice guidelines. Although liver biopsy remains the gold standard to diagnose NASH, less than 25% of respondents routinely require it to make the diagnosis of NASH. We conclude that NASH is underdiagnosed in gastroenterology and hepatology practices, highlighting the need to refine noninvasive diagnostic tools. C1 [Rinella, Mary E.] Northwestern Univ, Feinberg Sch Med, Div Gastroenterol & Hepatol, Med, 676 N St Clair,Arkes Pavillion 14-012, Chicago, IL 60611 USA. [Lominadze, Zurabi] Northwestern Univ, Feinberg Sch Med, Dept Med, Chicago, IL 60611 USA. [Loomba, Rohit] Univ Calif San Diego, Div Gastroenterol & Hepatol, La Jolla, CA 92093 USA. [Charlton, Michael] Intermt Med Ctr, Salt Lake City, UT USA. [Neuschwander-Tetri, Brent A.] St Louis Univ, Div Gastroenterol & Hepatol, St Louis, MO 63103 USA. [Caldwell, Stephen H.] Univ Virginia, Gastroenterol & Hepatol, Charlottesville, VA USA. [Kowdley, Kris] Swedish Med Ctr, Med Ctr, Div Gastroenterol & Hepatol, Seattle, WA USA. [Harrison, Stephen A.] Brooke Army Med Ctr, Div Gastroenterol & Hepatol, San Antonio, TX USA. RP Rinella, ME (reprint author), Northwestern Univ, Feinberg Sch Med, Div Gastroenterol & Hepatol, Med, 676 N St Clair,Arkes Pavillion 14-012, Chicago, IL 60611 USA. EM m-rinella@northwestern.edu NR 35 TC 13 Z9 13 U1 6 U2 8 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1756-283X EI 1756-2848 J9 THER ADV GASTROENTER JI Ther. Adv. Gastroenterol. PD JAN PY 2016 VL 9 IS 1 BP 4 EP 12 DI 10.1177/1756283X15611581 PG 9 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA DE1VT UT WOS:000370415300001 PM 26770262 ER PT J AU Peterson, MS Havrylkoff, JM Grammer, PO Mickle, PF Slack, WT AF Peterson, Mark S. Havrylkoff, Jeanne-Marie Grammer, Paul O. Mickle, Paul F. Slack, William T. TI Consistent SpatioTemporal Estuarine Habitat Use during Emigration or Immigration of a Western Population of Gulf Sturgeon SO TRANSACTIONS OF THE AMERICAN FISHERIES SOCIETY LA English DT Article ID ACIPENSER-OXYRINCHUS-DESOTOI; OF-MEXICO STURGEON; SUWANNEE RIVER ESTUARY; PASCAGOULA RIVER; LIFE-HISTORY; ATLANTIC STURGEON; FLORIDA; MOVEMENT; PATTERNS; MISSISSIPPI AB The spatial and seasonal occupancy by Gulf Sturgeon Acipenser oxyrinchus desotoi was estimated using acoustically tagged fish in the Pascagoula River estuary over a 3-year period (2010-2013) and was based on 131,381 detections. Juveniles spent considerably more time in the estuary than subadults or adults, but that varied by year. Gulf Sturgeon of all size-classes entered the acoustic array earlier when stream discharge was high (2011, 2012) compared with when it was lower (2010). The difference was about 14-28 d earlier for adults and subadults but only 12-17 d for juveniles. Temporally, there were no significant differences in occupancy by year or season for adults or subadults or by year for juvenile Gulf Sturgeon, suggesting repeated patterns across the 3 years of this study. Significant and consistent spatial differences in occupancy occurred by array zone, with juveniles occupying the West zone more than the East and River zones of the acoustic array; however, occupancy in the River zone was greater than in the East zone. We found similar patterns for subadults, with the highest occupancy in the West zone compared with the East zone; use was higher in the River zone than in the East zone but there was no difference between the River and West zones. In contrast, no year, season, or zone patterns were identified for adult Gulf Sturgeon, suggesting annual movement along a defined travel corridor (from the River zone to the West zone to offshore islands), with little time spent in the estuary. Adults appear to move quickly through the system during emigration (fall) and immigration (spring) compared with longer but more variable occupancy for juveniles and subadults. Our long-term data illustrates the importance of habitat connectivity in the recovery of Gulf Sturgeon and enhances earlier work on estuarine zones used during migration periods and estuarine residency; both are important for a better understanding of critical habitat maintenance and the development of a robust recovery plan. C1 [Peterson, Mark S.; Havrylkoff, Jeanne-Marie; Grammer, Paul O.] Univ So Mississippi, Dept Coastal Sci, 703 East Beach Dr, Ocean Springs, MS 39564 USA. [Mickle, Paul F.] Mississipi Dept Marine Resources, 1141 Bayview Ave, Biloxi, MS 39530 USA. [Slack, William T.] US Army Engineer Res & Dev Ctr, Waterways Expt Stn EE A, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. RP Peterson, MS (reprint author), Univ So Mississippi, Dept Coastal Sci, 703 East Beach Dr, Ocean Springs, MS 39564 USA. EM mark.peterson@usm.edu FU National Oceanic and Atmospheric Administration Office of Protected Species [NA10NMF4720034] FX We thank M. Roberts, K. Herrington, S. Bolden, I. Baremore, and D. Rosati for technical assistance. We also thank M. Lowe, E. Satterfield, B. Ennis, S. Ashworth, E. Lang, C. Matten, J. Green, P. Vick, A. Fogg, B. Lewis, S. George, and B. J. Johnson for field and laboratory assistance. Special thanks to two external reviewers whose comments improved this manuscript. We thank the National Oceanic and Atmospheric Administration Office of Protected Species for funding (NA10NMF4720034). This research was conducted under the University of Southern Mississippi's Institute of Animal Care and Use Committee number 07081501, 09091702, and 11092209. NR 61 TC 0 Z9 0 U1 1 U2 14 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 0002-8487 EI 1548-8659 J9 T AM FISH SOC JI Trans. Am. Fish. Soc. PY 2016 VL 145 IS 1 BP 27 EP 43 DI 10.1080/00028487.2015.1091382 PG 17 WC Fisheries SC Fisheries GA DE0ZP UT WOS:000370355000004 ER PT J AU Atwater, MA Darling, KA Tschopp, MA AF Atwater, Mark A. Darling, Kris A. Tschopp, Mark A. TI Solid-State Foaming by Oxide Reduction and Expansion: Tailoring the Foamed Metal Microstructure in the Cu-CuO System with Oxide Content and Annealing Conditions SO ADVANCED ENGINEERING MATERIALS LA English DT Article ID ARGON-FILLED PORES; COPPER FOAM; POROUS COPPER; SUPERPLASTIC EXPANSION; MECHANICAL-PROPERTIES; TITANIUM; FABRICATION; POROSITY; ELECTRODEPOSITION AB A new method of introducing porosity into solid metals was investigated using mixtures of Cu and CuO. The process involves distributing oxides through the Cu matrix (e.g., mechanical milling, as used here) and then reducing those oxides during annealing. The most distinguishing characteristic of this process is that pores develop within individual powder particles. In this study, we varied the oxide content (0-7 at% O), annealing temperature (400, 600, and 800 degrees C), and annealing time (up to 3 h) to investigate their effect on the foamed metal microstructure. In general, we find that the amount of porosity within the powder particles (or bulk part) can be controlled by varying of oxide content and annealing parameters. The maximum porosity of 47.4% corresponds to intermediate conditions of both temperature and oxide content (600 degrees C and approximate to 3 at% CuO, respectively). The pore size and grain size are small (<5 mu m) in comparison with other solid-state foaming techniques and are not highly sensitive to the annealing parameters used in the present study. The unique mechanisms and opportunities associated with this oxide reduction and expansion process are discussed for the Cu-CuO system as well as extensions to other metal systems. C1 [Atwater, Mark A.] Millersville Univ Pennsylvania, Dept Appl Engn Safety & Technol, Millersville, PA 17551 USA. [Atwater, Mark A.; Darling, Kris A.; Tschopp, Mark A.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Atwater, MA (reprint author), Millersville Univ Pennsylvania, Dept Appl Engn Safety & Technol, Millersville, PA 17551 USA.; Atwater, MA (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM mark.atwater@millersville.edu OI Tschopp, Mark/0000-0001-8471-5035 NR 43 TC 1 Z9 1 U1 2 U2 7 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 1438-1656 EI 1527-2648 J9 ADV ENG MATER JI Adv. Eng. Mater. PD JAN PY 2016 VL 18 IS 1 BP 83 EP 95 DI 10.1002/adem.201500063 PG 13 WC Materials Science, Multidisciplinary SC Materials Science GA DD8AL UT WOS:000370146000012 ER PT S AU Aydelotte, B Schuster, B AF Aydelotte, Brady Schuster, Brian BE Song, B Lamberson, L Casem, D Kimberley, J TI Observation and Modeling of Cone Cracks in Ceramics SO DYNAMIC BEHAVIOR OF MATERIALS, VOL 1 SE Conference Proceedings of the Society for Experimental Mechanics Series LA English DT Proceedings Paper CT Annual Conference and Exposition of the Society-for-Experimental-Mechanics on Experimental and Applied Mechanics CY JUN 08-11, 2015 CL Costa Mesa, CA SP Soc Expt Mech DE Cone crack; Impact; Indentation; Ceramic; Damage ID FRACTURE AB Ceramics undergo a complex failure process when subjected to impact by a projectile. Projectile impacts on thick ceramic targets produce varying levels of comminution, cone cracking, and radial cracking. Sphere impacts result in limited penetration and comminution relative to projectiles with a longer aspect ratio, yet significant radial and cone cracking is produced, and it is similar to Hertzian indentation. Sphere impact is a good way to study ceramics and a good validation problem to study the ability of hydrocodes to predict the formation and extent of radial and cone fractures in ceramic materials. Experimental results from normal and oblique sphere impacts on hot-pressed boron carbide cylinders are reported. Oblique sphere impacts created curved cone cracks, which did not appear oriented perpendicular to the impact surface. Cone angles appear to be the same for normal and oblique impacts for the impact conditions tested. Hydrocode predictions captured some but not all of the experimentally observed features. C1 [Aydelotte, Brady; Schuster, Brian] US Army Res Lab, RDRL WML H321 Colleran Rd, Aberdeen Proving Ground, MD 21005 USA. RP Aydelotte, B (reprint author), US Army Res Lab, RDRL WML H321 Colleran Rd, Aberdeen Proving Ground, MD 21005 USA. EM brady.b.aydelotte.civ@mail.mil NR 14 TC 0 Z9 0 U1 3 U2 4 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SN 2191-5644 BN 978-3-319-22452-7; 978-3-319-22451-0 J9 C PROC SOC EXP MECH PY 2016 BP 19 EP 23 DI 10.1007/978-3-319-22452-7_4 PG 5 WC Mechanics; Physics, Applied SC Mechanics; Physics GA BE2OQ UT WOS:000369724800004 ER PT S AU Casem, D Huskins, E Ligda, J Schuster, B AF Casem, Daniel Huskins, Emily Ligda, Jonathan Schuster, Brian BE Song, B Lamberson, L Casem, D Kimberley, J TI A Kolsky Bar for High-Rate Micro-compression: Preliminary Results SO DYNAMIC BEHAVIOR OF MATERIALS, VOL 1 SE Conference Proceedings of the Society for Experimental Mechanics Series LA English DT Proceedings Paper CT Annual Conference and Exposition of the Society-for-Experimental-Mechanics on Experimental and Applied Mechanics CY JUN 08-11, 2015 CL Costa Mesa, CA SP Soc Expt Mech DE Split Hopkinson Pressure Bar; Kolsky Bar; High-rate testing; Interferometers; Compression testing ID DISPLACEMENT AB Initial results from a Kolsky bar with a 127 mu m diameter are presented. The small diameter is used achieve high strain-rates and for compatibility with small (tens of microns) specimens. The bar is instrumented optically; a transverse displacement interferometer is used to measure the input and reflected pulses within the input bar and a normal displacement interferometer is used to measure the transmitted pulse in the output bar. It is shown using a simple elastic impact experiment that the pulses within the bars propagate as uniaxial stress waves according the elementary theory used in the standard analysis. An example application is also given where a niobium sample is loaded at a strain rate greater than 1 M/s. C1 [Casem, Daniel] US Army Res Lab, RDRL WMP C, Aberdeen, MD 21005 USA. [Huskins, Emily] US Naval Acad, 323 Rickover Hall, Annapolis, MD 21402 USA. [Ligda, Jonathan; Schuster, Brian] US Army Res Lab, RDRL WML H, Aberdeen, MD 21005 USA. RP Casem, D (reprint author), US Army Res Lab, RDRL WMP C, Aberdeen, MD 21005 USA. EM daniel.t.casem.civ@mail.mil NR 8 TC 0 Z9 0 U1 4 U2 7 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SN 2191-5644 BN 978-3-319-22452-7; 978-3-319-22451-0 J9 C PROC SOC EXP MECH PY 2016 BP 87 EP 92 DI 10.1007/978-3-319-22452-7_14 PG 6 WC Mechanics; Physics, Applied SC Mechanics; Physics GA BE2OQ UT WOS:000369724800014 ER PT S AU Ranade, R Heard, WF Williams, BA AF Ranade, Ravi Heard, William F. Williams, Brett A. BE Song, B Lamberson, L Casem, D Kimberley, J TI Multi-Scale Mechanical Performance of High Strength-High Ductility Concrete SO DYNAMIC BEHAVIOR OF MATERIALS, VOL 1 SE Conference Proceedings of the Society for Experimental Mechanics Series LA English DT Proceedings Paper CT Annual Conference and Exposition of the Society-for-Experimental-Mechanics on Experimental and Applied Mechanics CY JUN 08-11, 2015 CL Costa Mesa, CA SP Soc Expt Mech DE High strength-high ductility concrete; Impact resistance; High performance concrete; Micromechanics; Rate effects ID COMPOSITES; BEHAVIOR; MODEL AB A new fiber-reinforced cement-based composite, called High Strength-High Ductility Concrete (HSHDC) with unparalleled combination of compressive strength (> 150 MPa) and tensile ductility (> 3 %), has been recently developed. Due to such unique combination of properties, the specific energies of HSHDC under tension and compression at both pseudo-static and high strain rates are extremely high. The design of this engineered material is based on the fundamental principles of micromechanics which focus on the synchronous functioning of the fiber, the cementitious matrix, and their interface to achieve the desired material properties for a given structural application. For such micromechanics-based design to succeed, the material has been researched at several length scales ranging from micro-scale fiber/ matrix interactions to structural-scale impact resistance of HSHDC slabs. This paper summarizes the mechanical properties of HSHDC at various length scales to facilitate further development of this material and explore its potential for use in enhancing structural impact and blast resistance. C1 [Ranade, Ravi] SUNY Buffalo, 135 Ketter Hall, Buffalo, NY 14260 USA. [Heard, William F.; Williams, Brett A.] US Army Corps Engineers, ERDC, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. RP Ranade, R (reprint author), SUNY Buffalo, 135 Ketter Hall, Buffalo, NY 14260 USA. EM ranade@buffalo.edu RI Ranade, Ravi/I-6387-2013 OI Ranade, Ravi/0000-0001-6030-8371 NR 16 TC 0 Z9 0 U1 4 U2 8 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SN 2191-5644 BN 978-3-319-22452-7; 978-3-319-22451-0 J9 C PROC SOC EXP MECH PY 2016 BP 93 EP 101 DI 10.1007/978-3-319-22452-7_15 PG 9 WC Mechanics; Physics, Applied SC Mechanics; Physics GA BE2OQ UT WOS:000369724800015 ER PT S AU Meyer, CS AF Meyer, Christopher S. BE Song, B Lamberson, L Casem, D Kimberley, J TI Ballistic Perforation of Double Reinforced Concrete as a Function of Energy SO DYNAMIC BEHAVIOR OF MATERIALS, VOL 1 SE Conference Proceedings of the Society for Experimental Mechanics Series LA English DT Proceedings Paper CT Annual Conference and Exposition of the Society-for-Experimental-Mechanics on Experimental and Applied Mechanics CY JUN 08-11, 2015 CL Costa Mesa, CA SP Soc Expt Mech DE Numerical simulation; Reinforced concrete; Kinetic energy; Perforation; Residual velocity ID RIGID PROJECTILE; PENETRATION; TARGETS; OBLIQUE AB In an effort to better understand the energy required to breach double-reinforced concrete (DRC) walls it was attempted to estimate by numerical simulations the minimum kinetic energy required to perforate a DRC target. To this end, a parametric numerical study was conducted at the U.S. Army Research Laboratory. Large scale, high-fidelity, three-dimensional numerical simulations were conducted using an Eulerian shock physics code considering both eroding penetration and rigid body penetration. The parametric study investigated right cylindrical steel rods with masses of 500-2000 g and length-to-diameter ratios (L/D) of 1-10 impacting with velocities ranging from 500 to 1500 m/s, and perforating rebar reinforced concrete targets with a range of presented areas. This paper explores the numerical simulation results to consider the kinetic energy of perforation of DRC for the described range of conditions. Experimental results from the literature are compared with the numerical results. An empirical fit to the data is reported. C1 [Meyer, Christopher S.] US Army Res Lab, ATTN RDRL WML H, Aberdeen Proving Ground, MD 21005 USA. RP Meyer, CS (reprint author), US Army Res Lab, ATTN RDRL WML H, Aberdeen Proving Ground, MD 21005 USA. EM christopher.s.meyer12.civ@mail.mil NR 38 TC 0 Z9 0 U1 1 U2 4 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SN 2191-5644 BN 978-3-319-22452-7; 978-3-319-22451-0 J9 C PROC SOC EXP MECH PY 2016 BP 205 EP 211 DI 10.1007/978-3-319-22452-7_29 PG 7 WC Mechanics; Physics, Applied SC Mechanics; Physics GA BE2OQ UT WOS:000369724800029 ER PT J AU Sethi, J Palit, R Carroll, JJ Karamian, S Saha, S Biswas, S Naik, Z Trivedi, T Litz, MS Datta, P Chattopadhyay, S Donthi, R Garg, U Jadhav, S Jain, HC Kumar, S Mehta, D Naidu, BS Bhat, GH Sheikh, JA Sihotra, S Walker, PM AF Sethi, J. Palit, R. Carroll, J. J. Karamian, S. Saha, S. Biswas, S. Naik, Z. Trivedi, T. Litz, M. S. Datta, P. Chattopadhyay, S. Donthi, R. Garg, U. Jadhav, S. Jain, H. C. Kumar, S. Mehta, D. Naidu, B. S. Bhat, G. H. Sheikh, J. A. Sihotra, S. Walker, P. M. TI Low-lying states near the I-pi=6(+) isomer in Ag-108 SO JOURNAL OF PHYSICS G-NUCLEAR AND PARTICLE PHYSICS LA English DT Article DE isomer; nuclear structure; gamma ray spectroscopy; fusion evaporation reaction ID INDUCED DEPLETION; NEUTRON-CAPTURE; GAMMA; DECAY AB The low-lying states of Ag-108 near the I-pi = 6(+) isomer have been investigated with the B-11 + Mo-100 reaction at 39 MeV beam energy. We aim at understanding the structure of the states near the isomer and identifying possible isomer depletion paths. From the gamma-gamma and gamma-gamma-gamma coincidence analysis, spectroscopy of the excited states near the isomer has been carried out to establish new transitions and modification of the previously known level scheme. The present work suggests a total of three possible transitions at energies below 500 keV from the isomer to higher excited levels, whose subsequent decay can branch to the ground state. The spins and parities of these states have been established with angular correlation and polarization measurements. The branching ratios and multipolarities of the associated gamma-rays were used in the estimation of the integral cross section for induced isomer depletion via these states. The experimental data have been compared to the results of projected Hartree-Fock calculations to understand the configurations of the levels. C1 [Sethi, J.; Palit, R.; Saha, S.; Biswas, S.; Trivedi, T.; Donthi, R.; Jadhav, S.; Jain, H. C.; Naidu, B. S.] Tata Inst Fundamental Res, Homi Bhabha Rd, Bombay 400005, Maharashtra, India. [Carroll, J. J.; Litz, M. S.] US Army Res Lab, Adelphi, MD 20783 USA. [Karamian, S.] Joint Inst Nucl Res, Dubna 141980, Russia. [Naik, Z.] Sambalpur Univ, Sambalpur 768019, India. [Datta, P.] Ananda Mohan Coll, Kolkata 700009, India. [Chattopadhyay, S.] Saha Inst Nucl Phys, Kolkata 700064, India. [Garg, U.] Univ Notre Dame, Notre Dame, IN 46556 USA. [Kumar, S.] Univ Delhi, Delhi 110007, India. [Mehta, D.; Sihotra, S.] Panjab Univ, Chandigarh 160014, India. [Bhat, G. H.; Sheikh, J. A.] Univ Kashmir, Dept Phys, Srinagar 190006, Jammu & Kashmir, India. [Walker, P. M.] Univ Surrey, Dept Phys, Guildford GU2 7XH, Surrey, England. RP Palit, R (reprint author), Tata Inst Fundamental Res, Homi Bhabha Rd, Bombay 400005, Maharashtra, India. EM palit@tifr.res.in RI Palit, Rudrajyoti/F-5185-2012 FU Department of Science and Technology, Government of India [IR/S2/PF-03/2003-II]; US National Science Foundation [PHY-1068192]; UK Science and Technology Facilities Council [ST/L005743/1] FX The authors would like to thank the members of INGA Principal Investigating Coordination Committee and INGA collaboration for making the detectors available. The staff at TIFR-BARC Pelletron-LINAC Facility is gratefully acknowledged for the smooth operation of the accelerator. J J Carroll would like to thank C J Chiara for some useful discussions. This work was partially supported by the Department of Science and Technology, Government of India under Grant No. IR/S2/PF-03/2003-II, the US National Science Foundation (Grant No. PHY-1068192), and the UK Science and Technology Facilities Council under grant No. ST/L005743/1. NR 29 TC 2 Z9 2 U1 0 U2 1 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0954-3899 EI 1361-6471 J9 J PHYS G NUCL PARTIC JI J. Phys. G-Nucl. Part. Phys. PD JAN PY 2016 VL 43 IS 1 AR 015103 DI 10.1088/0954-3899/43/1/015103 PG 15 WC Physics, Nuclear; Physics, Particles & Fields SC Physics GA DD1SV UT WOS:000369703000009 ER PT J AU Tobler, KJ Oman, S Kolp, LA AF Tobler, Kyle J. Oman, Sarah Kolp, Lisa A. TI Retained Products of Conception Associated with Intravasation of Hysterosalpingogram Contrast and Hysteroscopic Distention Media A Case Report SO JOURNAL OF REPRODUCTIVE MEDICINE LA English DT Article DE hysterosalpingography; hysteroscopic ID RESIDUAL TROPHOBLASTIC TISSUE; MANAGEMENT AB BACKGROUND: Hysteroscopic resection of retained products of conception has not been previously described to increase the risk for volume overload at the time of hysteroscopy. CASE: A 35-year-old woman with a history of recurrent pregnancy loss was evaluated by a hysterosalpingogram that identified retained products of conception with adjacent contrast intravasation. She underwent a hysteroscopic resection of the uterine septum and products of conception. During the 15-minute operating time she developed a fluid deficit of 2,300 cc of 3% sorbitol with resulting hyponatremia despite normal pressure and flow settings on the fluid management equipment. CONCLUSION: When a hysterosalpingogram demonstrates likely retained products of conception with an accompanying intravasation of contrast media, the provider should consider this finding a potential risk factor for excess intravasation of hysteroscopic distention media and take additional precautions to avoid volume overload. C1 [Tobler, Kyle J.; Oman, Sarah; Kolp, Lisa A.] Johns Hopkins Univ, Sch Med, Dept Gynecol & Obstet, Div Reprod Endocrinol & Infertil, Baltimore, MD 21205 USA. RP Tobler, KJ (reprint author), Womack Army Med Ctr, Dept Obstet & Gynecol, Div Reprod Endocrinol & Infertil, 2817 Reilly Rd, Ft Bragg, NC 28307 USA. EM kyle.tobler@gmail.com NR 8 TC 0 Z9 0 U1 0 U2 0 PU SCI PRINTERS & PUBL INC PI ST LOUIS PA PO DRAWER 12425 8342 OLIVE BLVD, ST LOUIS, MO 63132 USA SN 0024-7758 EI 1943-3565 J9 J REPROD MED JI J. Reprod. Med. PD JAN-FEB PY 2016 VL 61 IS 1-2 BP 69 EP 72 PG 4 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA DD7PL UT WOS:000370116500013 PM 26995892 ER PT J AU Zhao, WJ Elias, AL Rajukumar, LP Kim, HI O'Brien, DJ Zimmerman, BK Penev, ES Terrones, M Yakobson, BI Wei, BQ Lu, XL Suhr, J AF Zhao, Wenjie Elias, Ana L. Rajukumar, Lakshmy P. Kim, Hyung-Ick O'Brien, Daniel J. Zimmerman, Brandon K. Penev, Evgeni S. Terrones, Mauricio Yakobson, Boris I. Wei, Bingqing Lu, X. Lucas Suhr, Jonghwan TI Controllable and Predictable Viscoelastic Behavior of 3D Boron-Doped Multiwalled Carbon Nanotube Sponges SO PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION LA English DT Article ID COMPOSITES; RECOVERY; AEROGELS; CREEP AB 3D carbon nanotube (CNT)-based macrostructures are the subject of extensive attention because the outstanding properties of 1D and 2D nanostructures have not been fully translated into key engineering applications. Generation of 3D CNT architectures with covalent junctions could endow the new materials with extraordinary mechanical properties. In this study, detailed experimental characterization and statistical comparison are carried out on 3D boron-doped multiwalled CNT (CBxMWNT) sponges with covalent junctions and undoped multiwalled CNT (undoped-MWNT) sponges without junctions. By investigating the plastic, elastic, viscoelastic, and dynamic viscoelastic properties of both sponges, as well as the dependency of these mechanical properties on material morphology, the CBxMWNT sponge is found to be a more predictable and stable material than the undoped-MWNT sponge. Statistical comparison proves that the excellent properties of the CBxMWNT are attributed to its "elbow-like" junctions inside the 3D networks, which prevent permanent buckling and bundling of the CNTs under extreme loading. Thus, by optimizing the covalent junctions in 3D CNT sponges, their functional behavior can be controlled and regulated. These findings may promote applications of 3D CNT sponges in various fields, including biomedical or high-precision devices in which lightweight, controllable, and reliable mechanical properties are always desirable. C1 [Zhao, Wenjie; Zimmerman, Brandon K.; Wei, Bingqing; Lu, X. Lucas] Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA. [Elias, Ana L.; Terrones, Mauricio] Penn State Univ, Dept Phys, 104 Davey Lab, University Pk, PA 16802 USA. [Elias, Ana L.; Terrones, Mauricio] Penn State Univ, Ctr Dimens & Layered Mat 2, 104 Davey Lab, University Pk, PA 16802 USA. [Rajukumar, Lakshmy P.; Terrones, Mauricio] Penn State Univ, Dept Mat Sci & Engn, 104 Davey Lab, University Pk, PA 16802 USA. [Kim, Hyung-Ick] Korea Inst Ind Technol, Reg Adv Mfg Technol Agcy, Jinju 660805, South Korea. [O'Brien, Daniel J.] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Penev, Evgeni S.; Yakobson, Boris I.] Rice Univ, Dept Mat Sci & NanoEngn, Houston, TX 77005 USA. [Terrones, Mauricio] Shinshu Univ, Res Ctr Exot Nanocarbons JST, Wakasato 4-17-1, Nagano 3808553, Japan. [Suhr, Jonghwan] Sungkyunkwan Univ, Dept Energy Sci, Dept Polymer Sci & Engn, 300 Chunchun Dong, Suwon 440746, South Korea. RP Lu, XL (reprint author), Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA.; Suhr, J (reprint author), Sungkyunkwan Univ, Dept Energy Sci, Dept Polymer Sci & Engn, 300 Chunchun Dong, Suwon 440746, South Korea. EM xlu@udel.edu; suhr@skku.edu RI Wei, Bingqing/A-4525-2008 OI Wei, Bingqing/0000-0002-9416-1731 FU U.S. Air Force Office of Scientific Research MURI Grant [FA9550-12-1-0035]; National Research Foundation of Korea [2014R1A2A2A01005496] FX This work was supported by the U.S. Air Force Office of Scientific Research MURI Grant (FA9550-12-1-0035) entitled "Synthesis and Characterization of 3D Carbon Nanotube Solid Networks." J.S. also would like to thank the financial support from the National Research Foundation of Korea (2014R1A2A2A01005496). NR 32 TC 0 Z9 0 U1 11 U2 27 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 0934-0866 EI 1521-4117 J9 PART PART SYST CHAR JI Part. Part. Syst. Charact. PD JAN PY 2016 VL 33 IS 1 BP 21 EP 26 DI 10.1002/ppsc.201500136 PG 6 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA DD8ON UT WOS:000370186600004 ER PT J AU Patel, JS Boddu, VM Brenner, MW Kumar, A AF Patel, Jignesh S. Boddu, Veera M. Brenner, Matthew W. Kumar, Ashok TI Effect of fabric structure and polymer matrix on flexural strength, interlaminar shear stress, and energy dissipation of glass fiber-reinforced polymer composites SO TEXTILE RESEARCH JOURNAL LA English DT Article DE glass fiber-reinforced polymer; flexural strength; interlaminar shear stress; energy dissipation; scanning electron microscope failure analysis ID WEAVE; BEHAVIOR AB We report the effect of glass fiber structure and the epoxy polymer system on the flexural strength, interlaminar shear stress (ILSS), and energy absorption properties of glass fiber-reinforced polymer (GFRP) composites. Four different GFRP composites were fabricated from two glass fiber textiles of different fabric count and strand density and two resin systems, a cycloaliphatic and a linear aliphatic system. These composites were fabricated using the vacuum-assisted resin transfer method. The flexural stress and ILSS data were obtained using a three-point bending test following ASTM 790-10 and ASTM D2344/D2344M standards. The GFRP composite sheet fabricated using a larger fabric count showed weak flexural strength as well as poor ILSS properties. However, it showed an average increase in energy dissipation of 95% and 7%, for resins SC780 and SC15, respectively, after five compression cycles over the measured range of compression strain. In comparison with the SC15 resin, the SC780 resin proved to have better flexural and ILSS properties but decreased energy dissipation. The results of this investigation help with the design of textile-reinforced composites for applications where bending strength, ILSS, and energy absorption are important. C1 [Patel, Jignesh S.; Boddu, Veera M.; Brenner, Matthew W.; Kumar, Ashok] US Army, Engineer Res & Dev Ctr, Construct Engn Res Lab, POB 9005, Champaign, IL 61826 USA. RP Boddu, VM (reprint author), US Army, Engineer Res & Dev Ctr, Construct Engn Res Lab, POB 9005, Champaign, IL 61826 USA. EM veera.boddu@usace.army.mil FU Oak Ridge Institute for Science and Education (ORISE) [DE-AC05-06OR23100] FX Mr. Jignesh S. Patel and Dr. Matthew W. Brenner were supported by an Oak Ridge Institute for Science and Education (ORISE) postdoctoral fellowship under contract number DE-AC05-06OR23100 between US Army ERDC and the US Department of Energy. NR 23 TC 0 Z9 0 U1 7 U2 8 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0040-5175 EI 1746-7748 J9 TEXT RES J JI Text. Res. J. PD JAN PY 2016 VL 86 IS 2 BP 127 EP 137 DI 10.1177/0040517515586165 PG 11 WC Materials Science, Textiles SC Materials Science GA DD5WS UT WOS:000369996000002 ER PT J AU Bell, TM Bunton, TE Shaia, CI Raymond, JW Honnold, SP Donnelly, GC Shamblin, JD Wilkinson, ER Cashman, KA AF Bell, T. M. Bunton, T. E. Shaia, C. I. Raymond, J. W. Honnold, S. P. Donnelly, G. C. Shamblin, J. D. Wilkinson, E. R. Cashman, K. A. TI Pathogenesis of Bolivian Hemorrhagic Fever in Guinea Pigs SO VETERINARY PATHOLOGY LA English DT Article DE aerosols; models; animal; arenaviruses; New World; Bolivia; viral hemorrhagic fever; American; Cavia porcellus; Machupo virus ID MACHUPO VIRUS-INFECTION; EPIDEMIOLOGY; ARENAVIRUSES; MANAGEMENT; PATHOLOGY; ANIMALS; WILD AB Machupo virus, the cause of Bolivian hemorrhagic fever, is a highly lethal viral hemorrhagic fever with no Food and Drug Administration-approved vaccines or therapeutics. This study evaluated the guinea pig as a model using the Machupo virus-Chicava strain administered via aerosol challenge. Guinea pigs (Cavia porcellus) were serially sampled to evaluate the temporal progression of infection, gross and histologic lesions, and sequential changes in serum chemistry and hematology. The incubation period was 5 to 12 days, and complete blood counts revealed leukopenia with lymphopenia and thrombocytopenia. Gross pathologic findings included congestion and hemorrhage of the gastrointestinal mucosa and serosa, noncollapsing lungs with fluid exudation, enlarged lymph nodes, and progressive pallor and friability of the liver. Histologic lesions consisted of foci of degeneration and cell death in the haired skin, liver, pancreas, adrenal glands, lymph nodes, tongue, esophagus, salivary glands, renal pelvis, small intestine, and large intestine. Lymphohistiocytic interstitial pneumonia was also present. Inflammation within the central nervous system, interpreted as nonsuppurative encephalitis, was histologically apparent approximately 16 days postexposure and was generally progressive. Macrophages in the tracheobronchial lymph node, on day 5 postexposure, were the first cells to demonstrate visible viral antigen. Viral antigen was detected throughout the lymphoid system by day 9 postexposure, followed by prominent spread within epithelial tissues and then brain. This study provides insight into the course of Machupo virus infection and supports the utility of guinea pigs as an additional animal model for vaccine and therapeutic development. C1 [Bell, T. M.; Bunton, T. E.; Shaia, C. I.; Raymond, J. W.; Honnold, S. P.; Donnelly, G. C.; Shamblin, J. D.; Wilkinson, E. R.; Cashman, K. A.] US Army, Med Res Inst Infect Dis, 1425 Porter St, Frederick, MD 21702 USA. [Bunton, T. E.] Eicarte LLC, Gettysburg, PA USA. [Shaia, C. I.] Joint Pathol Ctr, Silver Spring, MD USA. RP Bell, TM (reprint author), US Army, Med Res Inst Infect Dis, 1425 Porter St, Frederick, MD 21702 USA. EM todd.m.bell.mil@mail.mil FU US Army Medical Research Institute of Infectious Diseases [195743]; Defense Threat Reduction Agency, Joint Science and Technology Office / Translational Medical Technologies grant [TMTI_0045_09_RD_T] FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The research was performed under US Army Medical Research Institute of Infectious Diseases project No. 195743 and funded by a Defense Threat Reduction Agency, Joint Science and Technology Office / Translational Medical Technologies grant (TMTI_0045_09_RD_T). NR 30 TC 3 Z9 3 U1 2 U2 6 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0300-9858 EI 1544-2217 J9 VET PATHOL JI Vet. Pathol. PD JAN PY 2016 VL 53 IS 1 BP 190 EP 199 DI 10.1177/0300985815588609 PG 10 WC Pathology; Veterinary Sciences SC Pathology; Veterinary Sciences GA DD0SM UT WOS:000369629800019 PM 26139838 ER PT J AU Garcia, RA Tennent, DJ Chang, D Wenke, JC Sanchez, CJ AF Garcia, Rebecca A. Tennent, David J. Chang, David Wenke, Joseph C. Sanchez, Carlos J., Jr. TI An In Vitro Comparison of PMMA and Calcium Sulfate as Carriers for the Local Delivery of Gallium(III) Nitrate to Staphylococcal Infected Surgical Sites SO BIOMED RESEARCH INTERNATIONAL LA English DT Article ID ANTIMICROBIAL RELEASE KINETICS; ACRYLIC BONE-CEMENT; BIOFILM FORMATION; POLYMETHYLMETHACRYLATE BEADS; ACINETOBACTER-BAUMANNII; ANTIBACTERIAL THERAPY; ORTHOPEDIC INFECTIONS; REVISION SURGERY; IRON CHELATORS; MECHANISMS AB Antibiotic-loaded bone cements, including poly(methyl methacrylate) (PMMA) and calcium sulfate (CaSO4), are often used for treatment of orthopaedic infections involving Staphylococcus spp., although the effectiveness of this treatment modality may be limited due to the emergence of antimicrobial resistance and/or the development of biofilms within surgical sites. Gallium(III) is an iron analog capable of inhibiting essential iron-dependent pathways, exerting broad antimicrobial activity against multiple microorganisms, including Staphylococcus spp. Herein, we evaluated PMMA and CaSO4 as carriers for delivery of gallium(III) nitrate (Ga(NO3)(3)) to infected surgical sites by assessing the release kinetics subsequent to incorporation and antimicrobial activity against S. aureus and S. epidermidis. PMMA and to a lesser extentCaSO(4) were observed to be compatible as carriers for Ga(NO3)(3), eluting concentrations with antimicrobial activity against planktonic bacteria, inhibiting bacterial growth, and preventing bacterial colonization of beads, and effective against established bacterial biofilms of S. aureus and S. epidermidis. Collectively, our in vitro results indicate that PMMA is a more suitable carrier compared to CaSO4 for delivery of Ga(NO3)(3); moreover they provide evidence for the potential use of Ga(NO3)(3) with PMMA as a strategy for the prevention and/or treatment for orthopaedic infections. C1 [Garcia, Rebecca A.; Tennent, David J.; Chang, David; Wenke, Joseph C.; Sanchez, Carlos J., Jr.] US Army Inst Surg Res, Extrem Trauma & Regenerat Med, JBSA Ft Sam, Houston, TX USA. RP Sanchez, CJ (reprint author), US Army Inst Surg Res, Extrem Trauma & Regenerat Med, JBSA Ft Sam, Houston, TX USA. EM sanchezcj@livemail.uthscsa.edu FU Combat Casualty Research Program, Medical Research and Materiel Command FX This work was supported by intramural funding from the Combat Casualty Research Program, Medical Research and Materiel Command. NR 55 TC 1 Z9 1 U1 3 U2 6 PU HINDAWI LTD PI LONDON PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, WIT 5HE, ENGLAND SN 2314-6133 EI 2314-6141 J9 BIOMED RES INT JI Biomed Res. Int. PY 2016 AR 7078989 DI 10.1155/2016/7078989 PG 11 WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental SC Biotechnology & Applied Microbiology; Research & Experimental Medicine GA DC5LJ UT WOS:000369262200001 ER PT J AU White, RF Steele, L O'Callaghan, JP Sullivan, K Binns, JH Golomb, BA Bloom, FE Bunker, JA Crawford, F Graves, JC Hardie, A Klimas, N Knox, M Meggs, WJ Melling, J Philbert, MA Grashow, R AF White, Roberta F. Steele, Lea O'Callaghan, James P. Sullivan, Kimberly Binns, James H. Golomb, Beatrice A. Bloom, Floyd E. Bunker, James A. Crawford, Fiona Graves, Joel C. Hardie, Anthony Klimas, Nancy Knox, Marguerite Meggs, William J. Melling, Jack Philbert, Martin A. Grashow, Rachel TI Recent research on Gulf War illness and other health problems in veterans of the 1991 Gulf War: Effects of toxicant exposures during deployment SO CORTEX LA English DT Review DE Gulf War illness; Pesticide; Organophosphates; Sarin; Cyclosarin; Veterans' health ID POSTTRAUMATIC-STRESS-DISORDER; CHRONIC MULTISYMPTOM ILLNESS; BLOOD-BRAIN-BARRIER; NEURALLY-MEDIATED HYPOTENSION; POPULATION-BASED-SAMPLE; SELF-REPORTED SYMPTOMS; US ARMY VETERANS; PERSIAN-GULF; PYRIDOSTIGMINE BROMIDE; RISK-FACTORS AB Veterans of Operation Desert Storm/Desert Shield - the 1991 Gulf War (GW) - are a unique population who returned from theater with multiple health complaints and disorders. Studies in the U.S. and elsewhere have consistently concluded that approximately 25-32% of this population suffers from a disorder characterized by symptoms that vary somewhat among individuals and include fatigue, headaches, cognitive dysfunction, musculoskeletal pain, and respiratory, gastrointestinal and dermatologic complaints. Gulf War illness (GWI) is the term used to describe this disorder. In addition, brain cancer occurs at increased rates in subgroups of GW veterans, as do neuropsychological and brain imaging abnormalities. Chemical exposures have become the focus of etiologic GWI research because nervous system symptoms are prominent and many neurotoxicants were present in theater, including organophosphates (OPs), carbamates, and other pesticides; sarin/cyclosarin nerve agents, and pyridostigmine bromide (PB) medications used as prophylaxis against chemical warfare attacks. Psychiatric etiologies have been ruled out. This paper reviews the recent literature on the health of 1991 GW veterans, focusing particularly on the central nervous system and on effects of toxicant exposures. In addition, it emphasizes research published since 2008, following on an exhaustive review that was published in that year that summarizes the prior literature (RACGWI, 2008). We conclude that exposure to pesticides and/or to PB are causally associated with GWI and the neurological dysfunction in GW veterans. Exposure to sarin and cyclosarin and to oil well fire emissions are also associated with neurologically based health effects, though their contribution to development of the disorder known as GWI is less clear. Gene environment interactions are likely to have contributed to development of GWI in deployed veterans. The health consequences of chemical exposures in the GW and other conflicts have been called "toxic wounds" by veterans. This type of injury requires further study and concentrated treatment research efforts that may also benefit other occupational groups with similar exposure-related illnesses. (C) 2015 The Authors. Published by Elsevier Ltd. C1 [White, Roberta F.] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA. [Steele, Lea] Baylor Univ, Inst Biomed Studies, Waco, TX 76798 USA. [O'Callaghan, James P.] NIOSH, Mol Neurotoxicol Toxicol & Mol Biol Branch, Hlth Effects Lab Div, Ctr Dis Control & Prevent, MS 3014, Morgantown, WV USA. [Sullivan, Kimberly] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA. [Binns, James H.] Res Advisory Comm Gulf War Vet Illnesses, Phoenix, AZ USA. [Golomb, Beatrice A.] Univ Calif San Diego, La Jolla, CA 92093 USA. [Bloom, Floyd E.] Scripps Res Inst, Mol & Integrat Neurosci Dept, La Jolla, CA 92037 USA. [Bunker, James A.] Natl Gulf War Resource Ctr, Topeka, KS USA. [Crawford, Fiona] Roskamp Inst, TBI Res Program, Sarasota, FL USA. [Graves, Joel C.] US Army, Crestview, FL USA. [Hardie, Anthony] Vet Common Sense, Bradenton, FL USA. [Klimas, Nancy] Nova SE Univ, Inst Neuroimmune Med, Miami, FL USA. [Knox, Marguerite] McEntire Joint Natl Guard Base, Eastover, SC USA. [Meggs, William J.] E Carolina Univ, Sch Med, Brody Sch Med, Dept Emergency Med, 3ED311, Greenville, NC USA. [Melling, Jack] US Govt Accountabil Off, Salisbury, Wilts, England. [Philbert, Martin A.] Univ Michigan, Sch Publ Hlth, Ann Arbor, MI 48109 USA. [Grashow, Rachel] Northeastern Univ, Dept Civil & Environm Engn, Boston, MA 02115 USA. RP White, RF (reprint author), Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA. EM rwhite@bu.edu; Lea_Steele@baylor.edu; jdo5@cdc.gov; tty@bu.edu; Binns.Jim@gmail.com; bgolomb@popmail.ucsd.edu; fbloom@bloomsciassocs.net; desert-storm1991@outlook.com; fcrawford@RFDN.ORG; joelcgraves@gmail.com; anthony.d.hardie@gmail.com; nklimas@nova.edu; marguerite.l.knox.mil@mail.mil; meggsw@ecu.edu; jmelling@ptd.net; Philbert@umich.edu; r.grashow@neu.edu OI Sullivan, Kimberly/0000-0001-7940-6123 FU Intramural CDC HHS [CC999999] NR 158 TC 9 Z9 9 U1 10 U2 23 PU ELSEVIER MASSON PI MILANO PA VIA PALEOCAPA 7, 20121 MILANO, ITALY SN 0010-9452 EI 1973-8102 J9 CORTEX JI Cortex PD JAN PY 2016 VL 74 BP 449 EP 475 DI 10.1016/j.cortex.2015.08.022 PG 27 WC Behavioral Sciences; Neurosciences SC Behavioral Sciences; Neurosciences & Neurology GA DC8GS UT WOS:000369458500045 PM 26493934 ER PT J AU Sabatini, JJ Oyler, KD AF Sabatini, Jesse J. Oyler, Karl D. TI Recent Advances in the Synthesis of High Explosive Materials SO CRYSTALS LA English DT Review DE energetic materials; explosives; synthesis; organic chemistry; processing ID LEAD-FREE REPLACEMENT; ENERGETIC MATERIALS; SENSITIVITY; DECOMPOSITION; PERFORMANCE; KINETICS; DBX-1; POWER AB This review discusses the recent advances in the syntheses of high explosive energetic materials. Syntheses of some relevant modern primary explosives and secondary high explosives, and the sensitivities and properties of these molecules are provided. In addition to the synthesis of such materials, processing improvement and formulating aspects using these ingredients, where applicable, are discussed in detail. C1 [Sabatini, Jesse J.] US Army, Res Lab, Weapons & Mat Res Directorate WMRD Lethal Div, Energet Technol Branch, Aberdeen Proving Ground, MD 21005 USA. [Oyler, Karl D.] US Army, Armaments Res Dev & Engn Ctr, Energet Warheads & Mfg Directorate, Explos Dev Branch, Picatinny Arsenal, NJ 07806 USA. RP Sabatini, JJ (reprint author), US Army, Res Lab, Weapons & Mat Res Directorate WMRD Lethal Div, Energet Technol Branch, Aberdeen Proving Ground, MD 21005 USA.; Oyler, KD (reprint author), US Army, Armaments Res Dev & Engn Ctr, Energet Warheads & Mfg Directorate, Explos Dev Branch, Picatinny Arsenal, NJ 07806 USA. EM jesse.j.sabatini.civ@mail.mil; karl.d.oyler.civ@mail.mil FU US Army Research Laboratory (ARL); Armaments Research, Development & Engineering Center (ARDEC); Research, Development & Engineering Command (RDECOM); Ordnance Environmental Program (OEP) FX The authors are indebted to Brian D. Roos (ARL) and Noah Lieb (Hughes Associates, Inc.) for many insightful discussions pertaining to this review. Thomas M. Klapotke is gratefully acknowledged for his invitation in submitting this article. The authors thank the US Army Research Laboratory (ARL), the Armaments Research, Development & Engineering Center (ARDEC), the Research, Development & Engineering Command (RDECOM) and the Ordnance Environmental Program (OEP) for funding of this work. NR 53 TC 8 Z9 8 U1 12 U2 33 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 2073-4352 J9 CRYSTALS JI Crystals PD JAN PY 2016 VL 6 IS 1 AR 5 DI 10.3390/cryst6010005 PG 22 WC Crystallography; Materials Science, Multidisciplinary SC Crystallography; Materials Science GA DC9AH UT WOS:000369512000004 ER PT J AU Lamberson, L Eliasson, V Weerasooriya, T AF Lamberson, L. Eliasson, V. Weerasooriya, T. TI Quantitative Visualization of Dynamic Material Behavior SO EXPERIMENTAL MECHANICS LA English DT Editorial Material C1 [Lamberson, L.] Drexel Univ, Dept Mech Engn & Mech, 3141 Chestnut St, Philadelphia, PA 19104 USA. [Eliasson, V.] Univ So Calif, Dept Aerosp & Mech Engn, 854 Downey Way, Los Angeles, CA 90089 USA. [Weerasooriya, T.] Army Res Lab, Soldier Protect Sci Branch, Aberdeen Proving Ground, MD 21005 USA. RP Lamberson, L (reprint author), Drexel Univ, Dept Mech Engn & Mech, 3141 Chestnut St, Philadelphia, PA 19104 USA. EM les@drexel.edu NR 0 TC 0 Z9 0 U1 2 U2 4 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0014-4851 EI 1741-2765 J9 EXP MECH JI Exp. Mech. PD JAN PY 2016 VL 56 IS 1 SI SI BP 1 EP 2 DI 10.1007/s11340-015-0118-x PG 2 WC Materials Science, Multidisciplinary; Mechanics; Materials Science, Characterization & Testing SC Materials Science; Mechanics GA DC6JN UT WOS:000369326200001 ER PT J AU Sanborn, B Gunnarsson, CA Foster, M Weerasooriya, T AF Sanborn, B. Gunnarsson, C. A. Foster, M. Weerasooriya, T. TI Quantitative Visualization of Human Cortical Bone Mechanical Response: Studies on the Anisotropic Compressive Response and Fracture Behavior as a Function of Loading Rate SO EXPERIMENTAL MECHANICS LA English DT Article DE Cortical bone; Image correlation; Fracture toughness; Failure criteria ID SPLIT HOPKINSON BAR; CRACK-GROWTH-RESISTANCE; COMPACT-BONE; DYNAMIC FRACTURE; TOUGHNESS; FAILURE; MICROCRACKING; STIFFNESS; TISSUE; AGE AB Blast and impact events regularly cause damage to human tissues. Efforts to improve protective gear are made through numerical simulation of these events where human tissues are exposed to high-rate loading conditions. Accurate simulation results can only be obtained if constitutive models are used that are based on precisely carried out experimental studies. Experimental studies on bone are challenging because of the relatively brittle nature of bone as well as the importance of the bone being in a hydrated state prior to experiments to avoid changing the mechanical properties. Past studies have utilized strain gages which require a period of drying time to bond strain gages to the surface of the bone. In this study, rate dependent fracture and compressive responses of wet human femur bone are investigated with in situ quantitative visualization. The fracture properties of cortical bone are studied transverse to the longitudinal axis of the bone up to high stress intensity factor rates, and the rate dependent compressive response is investigated in both longitudinal and transverse directions. The rate dependent nature of the fracture response, and the compressive behavior of human cortical bone over a range of rates from 0.001-1000 s-1 is discussed with the aid of quantitative visualization. C1 [Sanborn, B.; Foster, M.] US Army, Res Lab, ORISE, Aberdeen, MD USA. [Gunnarsson, C. A.; Weerasooriya, T.] Army Res Lab, Aberdeen, MD USA. RP Weerasooriya, T (reprint author), Army Res Lab, Aberdeen, MD USA. EM Brett.sanborn2.ctr@mail.mil; tusit.weerasooriya.civ@mail.mil NR 41 TC 0 Z9 0 U1 2 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0014-4851 EI 1741-2765 J9 EXP MECH JI Exp. Mech. PD JAN PY 2016 VL 56 IS 1 SI SI BP 81 EP 95 DI 10.1007/s11340-015-0060-y PG 15 WC Materials Science, Multidisciplinary; Mechanics; Materials Science, Characterization & Testing SC Materials Science; Mechanics GA DC6JN UT WOS:000369326200007 ER PT J AU Morris, CL Brown, EN Agee, C Bernert, T Bourke, MAM Burkett, MW Buttler, WT Byler, DD Chen, CF Clarke, AJ Cooley, JC Gibbs, PJ Imhoff, SD Jones, R Kwiatkowski, K Mariam, FG Merrill, FE Murray, MM Olinger, CT Oro, DM Nedrow, P Saunders, A Terrones, G Trouw, F Tupa, D Vogan, W Winkler, B Wang, Z Zellner, MB AF Morris, C. L. Brown, E. N. Agee, C. Bernert, T. Bourke, M. A. M. Burkett, M. W. Buttler, W. T. Byler, D. D. Chen, C. F. Clarke, A. J. Cooley, J. C. Gibbs, P. J. Imhoff, S. D. Jones, R. Kwiatkowski, K. Mariam, F. G. Merrill, F. E. Murray, M. M. Olinger, C. T. Oro, D. M. Nedrow, P. Saunders, A. Terrones, G. Trouw, F. Tupa, D. Vogan, W. Winkler, B. Wang, Z. Zellner, M. B. TI New Developments in Proton Radiography at the Los Alamos Neutron Science Center (LANSCE) SO EXPERIMENTAL MECHANICS LA English DT Article DE Proton radiography; Dynamic materials; Static applications; Tomography; Detonation propagation; Richtmyer-Meshov instability; Metal jets; Casting; Fuel rods; Chelyabinsk; Meteorite ID COMBUSTION SYNTHESIS; X-RAY; ACCELERATOR; FACILITY; TA5SI3; TI5SI3 AB An application of nuclear physics, a facility for using protons for flash radiography, has been developed at the Los Alamos Neutron Science Center (LANSCE). Protons have proven far superior to high energy x-rays for flash radiography because of their long mean free path, good position resolution, and low scatter background. Although this facility is primarily used for studying very fast phenomena such as high explosive driven experiments, it is finding increasing application to other fields, such as tomography of static objects, phase changes in materials and the dynamics of chemical reactions. The advantages of protons are discussed, data from some recent experiments will be reviewed and concepts for new techniques are introduced. C1 [Morris, C. L.; Brown, E. N.; Bourke, M. A. M.; Burkett, M. W.; Buttler, W. T.; Byler, D. D.; Chen, C. F.; Clarke, A. J.; Cooley, J. C.; Gibbs, P. J.; Imhoff, S. D.; Kwiatkowski, K.; Mariam, F. G.; Merrill, F. E.; Murray, M. M.; Olinger, C. T.; Oro, D. M.; Nedrow, P.; Saunders, A.; Terrones, G.; Trouw, F.; Tupa, D.; Vogan, W.; Wang, Z.] Los Alamos Natl Lab, Los Alamos, NM 87544 USA. [Agee, C.; Jones, R.] Univ New Mexico, Albuquerque, NM 87131 USA. [Bernert, T.; Winkler, B.] Goethe Univ Frankfurt, Inst Geowissensch, Abt Kristallog, Altenhoferallee 1, D-60438 Frankfurt, Germany. [Zellner, M. B.] US Army, Res Lab, RDRL WMP D, Aberdeen, MD 21005 USA. RP Morris, CL (reprint author), Los Alamos Natl Lab, Los Alamos, NM 87544 USA. EM cmorris@lanl.gov OI Brown, Eric/0000-0002-6812-7820; Morris, Christopher/0000-0003-2141-0255; Tupa, Dale/0000-0002-6265-5016 FU U.S. Department of Energy (DOE) through LANL/LDRD Program [DE-AC5206NA25396]; U.S. DOE, Office of Basic Energy Sciences, Division of Materials Sciences and Engineering FX This work was performed under the auspices of the U.S. Department of Energy under Contract DE-AC5206NA25396. This work benefited from important contributions from the LANSCE pRad team and accelerator staff. We gratefully acknowledge the support of the U.S. Department of Energy (DOE) through the LANL/LDRD Program for this work. A. J. C., S. D. I., P. J. G. and the casting mold filling experiment were supported by A. J. C.'s Early Career award from the U.S. DOE, Office of Basic Energy Sciences, Division of Materials Sciences and Engineering. NR 44 TC 1 Z9 1 U1 3 U2 8 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0014-4851 EI 1741-2765 J9 EXP MECH JI Exp. Mech. PD JAN PY 2016 VL 56 IS 1 SI SI BP 111 EP 120 DI 10.1007/s11340-015-0077-2 PG 10 WC Materials Science, Multidisciplinary; Mechanics; Materials Science, Characterization & Testing SC Materials Science; Mechanics GA DC6JN UT WOS:000369326200009 ER PT J AU Warnell, G David, P Chellappa, R AF Warnell, Garrett David, Philip Chellappa, Rama TI Ray Saliency: Bottom-Up Visual Saliency for a Rotating and Zooming Camera SO INTERNATIONAL JOURNAL OF COMPUTER VISION LA English DT Article DE Visual saliency; Pan-tilt-zoom camera ID BINARY SEARCH TREES; SELF-CALIBRATION; ATTENTION; FEATURES AB We extend the classical notion of computational visual saliency to multi-image data collected using a stationary pan-tilt-zoom (PTZ) camera by introducing the concept of consistency: the requirement that the set of generated saliency maps should each assign the same saliency value to unique regions of the environment that appear in more than one image. We show that processing each image independently will often fail to provide a consistent measure of saliency, and that using an image mosaic to quantify saliency suffers from several drawbacks. We then propose ray saliency and an immediate extension, approximate ray saliency: a mosaic-free method for calculating a consistent measure of bottom-up saliency. Experimental results demonstrating the effectiveness of the proposed approach are presented. C1 [Warnell, Garrett; David, Philip] US Army, Res Lab, Adelphi, MD USA. [Chellappa, Rama] Univ Maryland, College Pk, MD 20742 USA. RP Warnell, G (reprint author), US Army, Res Lab, Adelphi, MD USA. EM garrett.a.warnell.civ@mail.mil FU U.S. Army Research Office (ARO) MURI Grant [W911NF-09-1-0383] FX Funding for this work was provided by U.S. Army Research Office (ARO) MURI Grant W911NF-09-1-0383. NR 39 TC 0 Z9 0 U1 4 U2 7 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0920-5691 EI 1573-1405 J9 INT J COMPUT VISION JI Int. J. Comput. Vis. PD JAN PY 2016 VL 116 IS 2 BP 174 EP 189 DI 10.1007/s11263-015-0842-9 PG 16 WC Computer Science, Artificial Intelligence SC Computer Science GA DC7TJ UT WOS:000369423000004 ER PT J AU Hennigar, SR McClung, JP AF Hennigar, Stephen R. McClung, James P. TI Homeostatic regulation of trace mineral transport by ubiquitination of membrane transporters SO NUTRITION REVIEWS LA English DT Review DE iron transport; ubiquitination; zinc transport; ZIP14 ID METAL-ION TRANSPORTER; EHLERS-DANLOS-SYNDROME; ZRT1 ZINC TRANSPORTER; SUBCELLULAR-LOCALIZATION; IRON UPTAKE; ACRODERMATITIS-ENTEROPATHICA; BIOCHEMICAL BASIS; LIV-1 SUBFAMILY; BREAST-CANCER; BOUND IRON AB Post-translational modification is a critical mechanism by which trace mineral transporters rapidly adapt to their environment to homeostatically regulate ion transport. Recently, a novel pathway was described whereby iron stimulates the ubiquitination and proteasomal degradation of the trace mineral transporter ZIP14. Discovery of this pathway suggests the proteasome as a potential therapeutic target for regulation of iron storage. Moreover, these findings contribute to a theoretical framework that can be applied to other ubiquitinated trace mineral transporters. This review will detail the current state of knowledge regarding the ubiquitination of trace mineral transporters, focusing on iron and zinc transporters, and the potential utility of post-translational modification of trace mineral transporters in the treatment of disease. C1 [Hennigar, Stephen R.; McClung, James P.] US Army, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. RP McClung, JP (reprint author), US Army, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. EM james.p.mcclung8.civ@mail.mil FU US Army Military Research and Material Command FX The authors thank Drs Phil Karl, Erin Gaffney-Stomberg, and Andrew Young for critical review of the manuscript. This manuscript was supported in part by the US Army Military Research and Material Command and appointment to the US Army Research Institute of Environmental Medicine administered by the Oak Ridge Institute for Science and Education (to S.R.H.) through an interagency agreement between the US Department of Energy and the US Army Medical Research and Material Command. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the US Army or the US Department of Defense. Any citations or commercial organizations and trade names in this report do not constitute an official Department of the Army endorsement of approval of the products or services of these organizations. NR 63 TC 4 Z9 4 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0029-6643 EI 1753-4887 J9 NUTR REV JI Nutr. Rev. PD JAN PY 2016 VL 74 IS 1 BP 59 EP 67 DI 10.1093/nutrit/nuv060 PG 9 WC Nutrition & Dietetics SC Nutrition & Dietetics GA DC9JQ UT WOS:000369538100005 PM 26611242 ER PT J AU Polyak, CS Yuhas, K Singa, B Khaemba, M Walson, J Richardson, BA John-Stewart, G AF Polyak, Christina S. Yuhas, Krista Singa, Benson Khaemba, Monica Walson, Judd Richardson, Barbra A. John-Stewart, Grace TI Cotrimoxazole Prophylaxis Discontinuation among Antiretroviral-Treated HIV-1-Infected Adults in Kenya: A Randomized Non-inferiority Trial SO PLOS MEDICINE LA English DT Article ID HIV-INFECTED ADULTS; PNEUMOCYSTIS-CARINII-PNEUMONIA; OPPORTUNISTIC INFECTIONS; TRIMETHOPRIM-SULFAMETHOXAZOLE; COTE-DIVOIRE; FOLLOW-UP; THERAPY; MORTALITY; MORBIDITY; MALARIA AB Background Cotrimoxazole (CTX) prophylaxis is recommended by the World Health Organization (WHO) for HIV-1-infected individuals in settings with high infectious disease prevalence. The WHO 2006 guidelines were developed prior to the scale-up of antiretroviral therapy (ART). The threshold for CTX discontinuation following ART is undefined in resource-limited settings. Methods and Findings Between 1 February 2012 and 30 September 2013, we conducted an unblinded non-inferiority randomized controlled trial of CTX prophylaxis cessation versus continuation among HIV-1-infected adults on ART for >= 18 mo with CD4 count >350 cells/mm(3) in a malaria-endemic region in Kenya. Participants were randomized and followed up at 3-mo intervals for 12 mo. The primary endpoint was a composite of morbidity (malaria, pneumonia, and diarrhea) and mortality. Incidence rate ratios (IRRs) were estimated using Poisson regression. Among 538 ART-treated adults screened, 500 were enrolled and randomized, 250 per arm. Median age was 40 y, 361 (72%) were women, and 442 (88%) reported insecticide-treated bednet use. Combined morbidity/mortality was significantly higher in the CTX discontinuation arm (IRR = 2.27, 95% CI 1.52-3.38; p < 0.001), driven by malaria morbidity. There were 34 cases of malaria, with 33 in the CTX discontinuation arm (IRR = 33.02, 95% CI 4.52-241.02; p = 0.001). Diarrhea and pneumonia rates did not differ significantly between arms (IRR = 1.36, 95% CI 0.82-2.27, and IRR = 1.43, 95% CI 0.54-3.75, respectively). Study limitations include a lack of placebo and a lower incidence of morbidity events than expected. Conclusions CTX discontinuation among ART-treated, immune-reconstituted adults in a malaria-endemic region resulted in increased incidence of malaria but not pneumonia or diarrhea. Malaria endemicity may be the most relevant factor to consider in the decision to stop CTX after ART-induced immune reconstitution in regions with high infectious disease prevalence. These data support the 2014 WHO CTX guidelines. C1 [Polyak, Christina S.] Walter Reed Army Inst Res, US Mil, HIV Res Program, Bethesda, MD USA. [Polyak, Christina S.; Walson, Judd; Richardson, Barbra A.; John-Stewart, Grace] Univ Washington, Dept Med, Seattle, WA USA. [Yuhas, Krista; Walson, Judd; Richardson, Barbra A.; John-Stewart, Grace] Univ Washington, Dept Global Hlth, Seattle, WA 98195 USA. [Singa, Benson; Khaemba, Monica] Kenya Govt Med Res Ctr, Nairobi, Kenya. [Walson, Judd; John-Stewart, Grace] Univ Washington, Dept Pediat, Seattle, WA 98195 USA. [Richardson, Barbra A.] Univ Washington, Dept Biostat, Seattle, WA 98195 USA. [John-Stewart, Grace] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA. RP Polyak, CS (reprint author), Walter Reed Army Inst Res, US Mil, HIV Res Program, Bethesda, MD USA.; Polyak, CS (reprint author), Univ Washington, Dept Med, Seattle, WA USA. EM cpolyak@hivresearch.org FU Merle A. Sande Award in International Infectious Diseases, Infectious Disease Society of America (IDSA); Armed Forces Health Surveillance Center - Department of Defense Global Emerging Infections System; NIAID of the National Institutes of Health; NCI of the National Institutes of Health; NIMH of the National Institutes of Health; NIDA of the National Institutes of Health; NICHD of the National Institutes of Health; NHLBI of the National Institutes of Health; NIA of the National Institutes of Health; NIGMS of the National Institutes of Health; NIDDK of the National Institutes of Health [P30AI027757]; NICHD [K24-HD054314] FX Supported by the Merle A. Sande Award in International Infectious Diseases, Infectious Disease Society of America (IDSA) (http://www.idsociety.org/Index.aspx) and the Armed Forces Health Surveillance Center - Department of Defense Global Emerging Infections System (http://www.afhsc.mil/Home/Divisions/GEIS). Research reported in this publication was also supported by NIAID, NCI, NIMH, NIDA, NICHD, NHLBI, NIA, NIGMS, NIDDK of the National Institutes of Health (www.nih.gov) under award number P30AI027757 and NICHD K24-HD054314 (GJS). Vestergaard Frandsen (http://www.vestergaard.com/) donated insecticide treated bednets and water filters. Alere Inc. (http://www.alere.com/ww/en.html) donated CD4 cartridges for Pima machines. The views expressed are those of the authors and should not be construed to represent the positions of the U.S. Army or the Department of Defense. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 29 TC 5 Z9 5 U1 0 U2 1 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1549-1676 J9 PLOS MED JI PLos Med. PD JAN PY 2016 VL 13 IS 1 AR e1001934 DI 10.1371/journal.pmed.1001934 PG 16 WC Medicine, General & Internal SC General & Internal Medicine GA DC7AL UT WOS:000369370600003 PM 26731191 ER PT J AU Nykaza, JR Ye, YS Nelson, RL Jackson, AC Beyer, FL Davis, EM Page, K Sharick, S Winey, KI Elabd, YA AF Nykaza, Jacob R. Ye, Yuesheng Nelson, Rachel L. Jackson, Aaron C. Beyer, Frederick L. Davis, Eric M. Page, Kirt Sharick, Sharon Winey, Karen I. Elabd, Yossef A. TI Polymerized ionic liquid diblock copolymers: impact of water/ion clustering on ion conductivity SO SOFT MATTER LA English DT Article ID ANION-EXCHANGE MEMBRANES; FUEL-CELL APPLICATIONS; ELECTROLYTE MEMBRANES; PROTON CONDUCTIVITY; BLOCK-COPOLYMERS; NAFION; MORPHOLOGY; TRANSPORT; ENHANCEMENT; IONOMER AB Herein, we examine the synergistic impact of both ion clustering and block copolymer morphology on ion conductivity in two polymerized ionic liquid (PIL) diblock copolymers with similar chemistries but different side alkyl spacer chain lengths (ethyl versus undecyl). When saturated in liquid water, water/ion clusters were observed only in the PIL block copolymer with longer alkyl side chains (undecyl) as evidenced by both small-angle neutron scattering and intermediate-angle X-ray scattering, i.e., water/ion clusters form within the PIL microdomain under these conditions. The resulting bromide ion conductivity in the undecyl sample was higher than the ethyl sample (14.0 mS cm(-1) versus 6.1 mS cm(-1) at 50 degrees C in liquid water) even though both samples had the same block copolymer morphology (lamellar) and the undecyl sample had a lower ion exchange capacity (0.9 meq g(-1) versus 1.4 meq g(-1)). No water/ion clusters were observed in either sample under high humidity or dry conditions. The resulting ion conductivity in the undecyl sample with lamellar morphology was significantly higher in the liquid water saturated state compared to the high humidity state (14.0 mS cm(-1) versus 4.2 mS cm(-1)), whereas there was no difference in ion conductivity in the ethyl sample when comparing these two states. These results show that small chemical changes to ion-containing block copolymers can induce water/ion clusters within block copolymer microdomains and this can subsequently have a significant effect on ion transport. C1 [Nykaza, Jacob R.; Ye, Yuesheng; Nelson, Rachel L.] Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA. [Jackson, Aaron C.; Beyer, Frederick L.] Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Davis, Eric M.] Clemson Univ, Dept Chem & Biomol Engn, Clemson, SC 29634 USA. [Page, Kirt] NIST, Mat Sci & Engn Div, Gaithersburg, MD 20899 USA. [Sharick, Sharon; Winey, Karen I.] Univ Penn, Dept Mat Sci & Engn, 3231 Walnut St, Philadelphia, PA 19104 USA. [Elabd, Yossef A.] Texas A&M Univ, Dept Chem Engn, College Stn, TX 77845 USA. RP Elabd, YA (reprint author), Texas A&M Univ, Dept Chem Engn, College Stn, TX 77845 USA. EM elabd@tamu.edu RI Elabd, Yossef/G-9866-2014 OI Elabd, Yossef/0000-0002-7790-9445 FU U.S. Army Research Office [W911NF-14-0310, W911NF-07-1-0452, W911NF-13-1-0363]; Nanotechnology Institute [NTI 1001-037]; National Research Council (NRC) Research Associateship Program (RAP); USARL FX The research at Drexel University and Texas A&M University was supported in part by the U.S. Army Research Office under grant no. W911NF-14-0310, W911NF-07-1-0452 and the Nanotechnology Institute under grant no. NTI 1001-037. The research at NIST was supported in part by the National Research Council (NRC) Research Associateship Program (RAP). The research at USARL was supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USARL. The research at the University of Pennsylvania was supported in part by the U.S. Army Research Office under grant no. W911NF-13-1-0363. NR 44 TC 6 Z9 6 U1 10 U2 42 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1744-683X EI 1744-6848 J9 SOFT MATTER JI Soft Matter PY 2016 VL 12 IS 4 BP 1133 EP 1144 DI 10.1039/c5sm02053k PG 12 WC Chemistry, Physical; Materials Science, Multidisciplinary; Physics, Multidisciplinary; Polymer Science SC Chemistry; Materials Science; Physics; Polymer Science GA DD2JF UT WOS:000369747900017 PM 26575014 ER PT J AU Lim, RB AF Lim, Robert B. TI Comment on: Comprehensive evaluation of the effect of bariatric surgery on pelvic floor disorders SO SURGERY FOR OBESITY AND RELATED DISEASES LA English DT Editorial Material C1 [Lim, Robert B.] Tripler Army Med Ctr, Honolulu, HI USA. RP Lim, RB (reprint author), Tripler Army Med Ctr, Honolulu, HI USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1550-7289 EI 1878-7533 J9 SURG OBES RELAT DIS JI Surg. Obes. Relat. Dis. PD JAN PY 2016 VL 12 IS 1 BP 143 EP 143 PG 1 WC Surgery SC Surgery GA DC8JY UT WOS:000369466900020 PM 26433643 ER PT J AU Ippolito, DL AbdulHameed, MDM Tawa, GJ Baer, CE Permenter, MG McDyre, BC Dennis, WE Boyle, MH Hobbs, CA Streicker, MA Snowden, BS Lewis, JA Wallqvist, A Stallings, JD AF Ippolito, Danielle L. AbdulHameed, Mohamed Diwan M. Tawa, Gregory J. Baer, Christine E. Permenter, Matthew G. McDyre, Bonna C. Dennis, William E. Boyle, Molly H. Hobbs, Cheryl A. Streicker, Michael A. Snowden, Bobbi S. Lewis, John A. Wallqvist, Anders Stallings, Jonathan D. TI Gene Expression Patterns Associated With Histopathology in Toxic Liver Fibrosis SO TOXICOLOGICAL SCIENCES LA English DT Article DE toxic liver injury; transcriptomics; bioinformatics; fibrosis; biomarkers; histopathology ID HEPATIC STELLATE CELLS; DIBENZO-P-DIOXINS; CARBON-TETRACHLORIDE; SUBCHRONIC/CHRONIC TOXICITY; GROWTH-FACTOR; 1,2,3,4,6,7,8-HEPTACHLORODIBENZO-P-DIOXIN HPCDD; CIRRHOTIC LIVER; LUNG FIBROSIS; MOUSE MODEL; SHORT-TERM AB Toxic industrial chemicals induce liver injury, which is difficult to diagnose without invasive procedures. Identifying indicators of end organ injury can complement exposure-based assays and improve predictive power. A multiplexed approach was used to experimentally evaluate a panel of 67 genes predicted to be associated with the fibrosis pathology by computationally mining DrugMatrix, a publicly available repository of gene microarray data. Five-day oral gavage studies in male Sprague Dawley rats dosed with varying concentrations of 3 fibrogenic compounds (allyl alcohol, carbon tetrachloride, and 4,4'-methylenedianiline) and 2 nonfibrogenic compounds (bromobenzene and dexamethasone) were conducted. Fibrosis was definitively diagnosed by histopathology. The 67-plex gene panel accurately diagnosed fibrosis in both microarray and multiplexed-gene expression assays. Necrosis and inflammatory infiltration were comorbid with fibrosis. ANOVA with contrasts identified that 51 of the 67 predicted genes were significantly associated with the fibrosis phenotype, with 24 of these specific to fibrosis alone. The protein product of the gene most strongly correlated with the fibrosis phenotype PCOLCE (Procollagen C-Endopeptidase Enhancer) was dose-dependently elevated in plasma from animals administered fibrogenic chemicals (P < .05). Semiquantitative global mass spectrometry analysis of the plasma identified an additional 5 protein products of the gene panel which increased after fibrogenic toxicant administration: fibronectin, ceruloplasmin, vitronectin, insulin-like growth factor binding protein, and alpha 2-macroglobulin. These results support the data mining approach for identifying gene and/or protein panels for assessing liver injury and may suggest bridging biomarkers for molecular mediators linked to histopathology. C1 [Ippolito, Danielle L.; Dennis, William E.; Lewis, John A.; Stallings, Jonathan D.] USACEHR, Environm Hlth Program, Ft Detrick, MD 21702 USA. [AbdulHameed, Mohamed Diwan M.; Tawa, Gregory J.; Wallqvist, Anders] US Army, Dept Def, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr,Med Res & Mat Comma, Ft Detrick, MD 21702 USA. [Baer, Christine E.; Permenter, Matthew G.] Excet Inc, Frederick, MD 21702 USA. [McDyre, Bonna C.] Oak Ridge Inst Sci & Educ, Frederick, MD 21702 USA. [Boyle, Molly H.; Hobbs, Cheryl A.; Streicker, Michael A.] Integrated Syst Lab, Res Triangle Pk, NC 27709 USA. [Snowden, Bobbi S.] Univ Maryland, Sch Publ Hlth, Maryland Inst Appl Environm Hlth, College Pk, MD 20742 USA. [Tawa, Gregory J.] NIH, Translat Med Div, Bldg 10, Bethesda, MD 20892 USA. RP Ippolito, DL (reprint author), US Army, Biomarkers Program, Ctr Environm Hlth Res, 568 Doughten Dr, Ft Detrick, MD 21702 USA. EM Danielle.L.Ippolito2.civ@mail.mil FU Military Operational Medicine Research Program; U.S. Army's Network Science Initiative, U.S. Army Medical Research and Materiel Command, Fort Detrick, Maryland; U.S. Department of Energy; U.S. Army Medical Research and Materiel Command FX The work was supported by the Military Operational Medicine Research Program and the U.S. Army's Network Science Initiative, U.S. Army Medical Research and Materiel Command, Fort Detrick, Maryland. This work was also supported in part by an appointment at U.S. Army Center for Environmental Health Research administered by Oak Ridge Institute for Science and Education through an interagency agreement between U.S. Department of Energy and U.S. Army Medical Research and Materiel Command [B.C.M.]. NR 128 TC 3 Z9 3 U1 4 U2 5 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1096-6080 EI 1096-0929 J9 TOXICOL SCI JI Toxicol. Sci. PD JAN PY 2016 VL 149 IS 1 BP 67 EP 88 DI 10.1093/toxsci/kfv214 PG 22 WC Toxicology SC Toxicology GA DC5BA UT WOS:000369233900007 PM 26396155 ER PT J AU Martins, KAO Cooper, CL Stronsky, SM Norris, SLW Kwilas, SA Steffens, JT Benko, JG van Tongeren, SA Bavari, S AF Martins, Karen A. O. Cooper, Christopher L. Stronsky, Sabrina M. Norris, Sarah L. W. Kwilas, Steven A. Steffens, Jesse T. Benko, Jacqueline G. van Tongeren, Sean A. Bavari, Sina TI Adjuvant-enhanced CD4 T Cell Responses are Critical to Durable Vaccine Immunity SO EBIOMEDICINE LA English DT Article DE Vaccine; Adjuvant; Durable protection; Immune correlates; Ebola virus ID VIRUS-LIKE PARTICLES; (HPV)-16/18 AS04-ADJUVANTED VACCINE; PROTECTS NONHUMAN-PRIMATES; HEPATITIS-B-VACCINE; EBOLA-VIRUS; LETHAL EBOLA; DENDRITIC CELLS; HPV-6/11/16/18 VACCINE; RENAL-INSUFFICIENCY; TARGETED VACCINE AB Protein-based vaccines offer a safer alternative to live-attenuated or inactivated vaccines but have limited immunogenicity. The identification of adjuvants that augment immunogenicity, specifically in a manner that is durable and antigen-specific, is therefore critical for advanced development. In this study, we use the filovirus virus-like particle (VLP) as a model protein-based vaccine in order to evaluate the impact of four candidate vaccine adjuvants on enhancing long term protection from Ebola virus challenge. Adjuvants tested include poly-ICLC (Hiltonol), MPLA, CpG 2395, and alhydrogel. We compared and contrasted antibody responses, neutralizing antibody responses, effector T cell responses, and T follicular helper (Tfh) cell frequencies with each adjuvant's impact on durable protection. We demonstrate that in this system, the most effective adjuvant elicits a Th1-skewed antibody response and strong CD4 T cell responses, including an increase in Tfh frequency. Using immune-deficient animals and adoptive transfer of serum and cells from vaccinated animals into naive animals, we further demonstrate that serum and CD4 T cells play a critical role in conferring protection within effective vaccination regimens. These studies inform on the requirements of long term immune protection, which can potentially be used to guide screening of clinical-grade adjuvants for vaccine clinical development. (C) 2015 The Authors. Published by Elsevier B.V. C1 [Martins, Karen A. O.; Cooper, Christopher L.; Stronsky, Sabrina M.; Steffens, Jesse T.; Benko, Jacqueline G.; van Tongeren, Sean A.; Bavari, Sina] US Army Med Res Inst Infect Dis, Mol & Translat Sci, 1425 Porter St, Ft Detrick, MD 21702 USA. [Kwilas, Steven A.] US Army Med Res Inst Infect Dis, Div Virol, 1425 Porter St, Ft Detrick, MD 21702 USA. [Norris, Sarah L. W.] US Army Med Res Inst Infect Dis, Res Support Div, 1425 Porter St, Ft Detrick, MD 21702 USA. RP Bavari, S (reprint author), US Army Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. EM sina.bavari.civ@mail.mil OI Stronsky, Sabrina/0000-0001-5964-3156 NR 87 TC 2 Z9 2 U1 1 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 2352-3964 J9 EBIOMEDICINE JI EBioMedicine PD JAN PY 2016 VL 3 BP 67 EP 78 DI 10.1016/j.ebiom.2015.11.041 PG 12 WC Medicine, General & Internal SC General & Internal Medicine GA DC1ZA UT WOS:000369015800014 PM 26870818 ER PT J AU Gibson, AM Cohen, GW Boyce, KK Houston, MN Bacon, CEW AF Gibson, Amy M. Cohen, Gary W. Boyce, Kelly K. Houston, Megan N. Bacon, Cailee E. Welch TI Personal and Environmental Characteristics Associated With Burnout in Athletic Trainers: A Critically Appraised Topic SO INTERNATIONAL JOURNAL OF ATHLETIC THERAPY & TRAINING LA English DT Article AB Clinical Question: What personal and environmental characteristics are associated with burnout in athletic trainers, as measured by the Maslach Burnout Inventory (MBI) and Athletic Training Burnout Inventory (ATBI)? Clinical Bottom Line: There is strong evidence suggesting that personal and environmental factors are associated with burnout in athletic trainers, as measured by the MBI and ATBI. While it is difficult to identify a single contributing factor that increases the athletic trainer's perception of burnout, athletic trainers should be aware of the characteristics associated with the condition and take appropriate action to reduce the risk of burnout. C1 [Gibson, Amy M.; Cohen, Gary W.; Boyce, Kelly K.; Bacon, Cailee E. Welch] AT Still Univ, Athlet Training Program, Mesa, AZ 85206 USA. [Houston, Megan N.] Keller Army Hosp, West Point, NY 10996 USA. RP Gibson, AM (reprint author), AT Still Univ, Athlet Training Program, Mesa, AZ 85206 USA. NR 12 TC 0 Z9 0 U1 1 U2 1 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA SN 2157-7277 EI 2157-7285 J9 INT J ATHL THER TRAI JI Int. J. Athl. Ther. Train. PD JAN PY 2016 VL 21 IS 1 BP 5 EP 13 DI 10.1123/ijatt.2015-0017 PG 9 WC Sport Sciences SC Sport Sciences GA DC3VJ UT WOS:000369146700002 ER PT J AU Schyman, P Liu, RF Wallqvist, A AF Schyman, Patric Liu, Ruifeng Wallqvist, Anders TI General Purpose 2D and 3D Similarity Approach to Identify hERG Blockers SO JOURNAL OF CHEMICAL INFORMATION AND MODELING LA English DT Article ID K+ CHANNEL; POTASSIUM CHANNELS; CARDIAC-ARRHYTHMIA; QSAR MODELS; DE-POINTES; I-KR; CLASSIFICATION; BLOCKADE; INHIBITION; PREDICTION AB Screening compounds for human ether-a-go-go-related gene (hERG) channel inhibition is an important component of early stage drug development and assessment. In this study, we developed a high-confidence (p-value < 0.01) hERG prediction model based on a combined two-dimensional (2D) and three-dimensional (3D) modeling approach. We developed a 3D similarity conformation approach (SCA) based on examining a limited fixed number of pairwise 3D similarity scores between a query molecule and a set of known hERG blockers. By combining 3D SCA with 2D similarity ensemble approach (SEA) methods, we achieved a maximum sensitivity in hERG inhibition prediction with an accuracy not achieved by either method separately. The combined model achieved 69% sensitivity and 95% specificity on an independent external data set. Further validation showed that the model correctly picked up documented hERG inhibition or interactions among the Food and Drug Administration- approved drugs with the highest similarity scores with 18 of 20 correctly identified. The combination of ascertaining 2D and 3D similarity of compounds allowed us to synergistically use 2D fingerprint matching with 3D shape and chemical complementarity matching. C1 [Schyman, Patric; Liu, Ruifeng; Wallqvist, Anders] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, DoD Biotechnol High Performance Comp Software App, 2405 Whittier Dr, Frederick, MD 21702 USA. RP Schyman, P; Wallqvist, A (reprint author), US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, DoD Biotechnol High Performance Comp Software App, 2405 Whittier Dr, Frederick, MD 21702 USA. EM pschyman@bhsai.org; sven.a.wallqvist.civ@mail.mil RI Schyman, Patric/F-1810-2011 FU U.S. Army Medical Research and Materiel Command; Defense Threat Reduction Agency [CBCall14-CBS-05-2-0007] FX The authors were supported by the U.S. Army Medical Research and Materiel Command (Ft. Detrick, MD) and the Defense Threat Reduction Agency grant CBCall14-CBS-05-2-0007. High-performance computing resources were made available by the U.S. Department of Defense High Performance Computing Modernization Program. The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U.S. Army or of the U.S. Department of Defense. This paper has been approved for public release with unlimited distribution. NR 52 TC 1 Z9 1 U1 2 U2 7 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1549-9596 EI 1549-960X J9 J CHEM INF MODEL JI J. Chem Inf. Model. PD JAN PY 2016 VL 56 IS 1 BP 213 EP 222 DI 10.1021/acs.jcim.5b00616 PG 10 WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Computer Science, Information Systems; Computer Science, Interdisciplinary Applications SC Pharmacology & Pharmacy; Chemistry; Computer Science GA DB9VA UT WOS:000368864600019 PM 26718126 ER PT J AU Koontz, JM Kumsher, DM Kelly, R Stallings, JD AF Koontz, Jason M. Kumsher, David M. Kelly, Richard, III Stallings, Jonathan D. TI Effect of 2 Bedding Materials on Ammonia Levels in Individually Ventilated Cages SO JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE LA English DT Article ID WELFARE; HEALTH; MICE AB This study sought to identify an optimal rodent bedding and cage-change interval to establish standard procedures for the IVC in our rodent vivarium. Disposable cages were prefilled with either corncob or alpha-cellulose bedding and were used to house 2 adult Sprague Dawley rats (experimental condition) or contained no animals (control). Rats were observed and intracage ammonia levels measured daily for 21 d. Intracage ammonia accumulation became significant by day 8 in experimental cages containing alpha-cellulose bedding, whereas experimental cages containing corncob bedding did not reach detectable levels of ammonia until day 14. In all 3 experimental cages containing alpha-cellulose, ammonia exceeded 100 ppm (our maximum acceptable limit) by day 11. Two experimental corncob cages required changing at days 16 and 17, whereas the remaining cage containing corncob bedding lasted the entire 21 d without reaching the 100-ppm ammonia threshold. These data suggests that corncob bedding provides nearly twice the service life of alpha-cellulose bedding in the IVC system. C1 [Koontz, Jason M.; Stallings, Jonathan D.] US Army, Ctr Environm Hlth Res, Ft Detrick, MD USA. [Kumsher, David M.] Excet, Ft Detrick, MD USA. [Kelly, Richard, III] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Koontz, JM (reprint author), US Army, Ctr Environm Hlth Res, Ft Detrick, MD USA. EM jason.m.koontz6.civ@mail.mil NR 14 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI MEMPHIS PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA SN 1559-6109 J9 J AM ASSOC LAB ANIM JI J. Amer. Assoc. Lab. Anim. Sci. PD JAN PY 2016 VL 55 IS 1 BP 25 EP 28 PG 4 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA DC2JT UT WOS:000369043700007 PM 26817976 ER PT J AU Takhampunya, R Tippayachai, B Korkusol, A Promsathaporn, S Leepitakrat, S Sinwat, W Schuster, AL Richards, AL AF Takhampunya, Ratree Tippayachai, Bousaraporn Korkusol, Achareeya Promsathaporn, Sommai Leepitakrat, Surachai Sinwat, Warattaya Schuster, Anthony L. Richards, Allen L. TI Transovarial Transmission of Co-Existing Orientia tsutsugamushi Genotypes in Laboratory-Reared Leptotrombidium imphalum SO VECTOR-BORNE AND ZOONOTIC DISEASES LA English DT Article DE Transovarial transmission; Co-existing genotypes; Orientia tsutsugamushi; Leptotrombidium imphalum; Scrub typhus ID POLYMERASE-CHAIN-REACTION; ELECTRON-MICROSCOPIC OBSERVATIONS; RICKETTSIA-TSUTSUGAMUSHI; SCRUB TYPHUS; VERTICAL TRANSMISSION; TROMBICULIDAE; ACARI; PALLIDUM; CHIGGERS; IDENTIFICATION AB The co-evolution of Orientia tsutsugamushi and its vector/host Leptotrombidium mites is important for this bacterium to survive and exist in its environment. The data in this study demonstrated that O. tsutsugamushi has adapted to take advantage of the parasitic nature of the host's larval stage and thus increase its chance of transmission to a vertebrate host and potentially to other vector mites by increasing its density at the time of transmission. Our data demonstrated that during the larval stage the density of O. tsutsugamushi was at its highest level compared to other life stages (Kruskal-Wallis, p<0.0001). We further revealed that the different O. tsutsugamushi 56-kDa type-specific antigen (TSA) genotypes within the mite were maintained and preserved during transovarial transmission from the Leptotrombidium imphalum, lines Li-3 and Li-5. No sequence difference of 56-kDa TSA gene (variable domain I-III, 765bp) was observed between the UT302-like genotype found in mothers and their offspring (100% identity). However, one or two nonsynonymous mutations in the 56-kDa TSA gene were observed in the Karp-like genotypes found in the F1 offspring with a percent difference ranging from 0.13 to 0.26 for nucleotide sequences and from 0.39 to 0.78 for amino acid sequences. Additionally, the composition of co-existing O. tsutsugamushi genotypes was maintained in L. imphalum lines through transsovarial and transstadial transmission processes; however, the proportion of these genotypes in each stage varied (larva, nymph, adult). These results show some of the key characteristics of O. tsutsugamushi maintenance within and transmission among its vector/host L. imphalum. C1 [Takhampunya, Ratree; Tippayachai, Bousaraporn; Korkusol, Achareeya; Promsathaporn, Sommai; Leepitakrat, Surachai; Sinwat, Warattaya; Schuster, Anthony L.] US Army Med Component Armed Forces Res Inst Med S, Dept Entomol, Bangkok, Thailand. [Richards, Allen L.] Naval Med Res Ctr, Viral & Rickettsial Dis Dept, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. RP Richards, AL (reprint author), Naval Med Res Ctr, Viral & Rickettsial Dis Dept, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM allen.l.richards.civ@mail.mil FU DoD MIDRP program [6000.RAD1.WJ.A0310] FX We are grateful for Mr. Taweesak Monkanna and Mr. Opas Thachinin managing the mite colony and in providing mite specimens for this study. This work was supported by the DoD MIDRP program work unit # 6000.RAD1.WJ.A0310. NR 22 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-3667 EI 1557-7759 J9 VECTOR-BORNE ZOONOT JI Vector-Borne Zoonotic Dis. PD JAN 1 PY 2016 VL 16 IS 1 BP 33 EP 41 DI 10.1089/vbz.2014.1753 PG 9 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA DB6EJ UT WOS:000368606000006 PM 26771218 ER PT J AU Dretsch, MN Williams, K Emmerich, T Crynen, G Ait-Ghezala, G Chaytow, H Mathura, V Crawford, FC Iverson, GL AF Dretsch, Michael N. Williams, Kathy Emmerich, Tanja Crynen, Gogce Ait-Ghezala, Ghania Chaytow, Helena Mathura, Venkat Crawford, Fiona C. Iverson, Grant L. TI Brain-derived neurotropic factor polymorphisms, traumatic stress, mild traumatic brain injury, and combat exposure contribute to postdeployment traumatic stress SO BRAIN AND BEHAVIOR LA English DT Article DE BDNF; deployment; genetics; military; posttraumatic stress disorder; psychological health; traumatic brain injury ID DOPAMINE-RECEPTOR GENE; ALZHEIMERS-DISEASE; DRD2 GENE; BINDING CHARACTERISTICS; HEALTHY-VOLUNTEERS; COGNITIVE RESERVE; APOE GENOTYPE; USE DISORDERS; ALCOHOL-USE; A1 ALLELE AB Background In addition to experiencing traumatic events while deployed in a combat environment, there are other factors that contribute to the development of posttraumatic stress disorder (PTSD) in military service members. This study explored the contribution of genetics, childhood environment, prior trauma, psychological, cognitive, and deployment factors to the development of traumatic stress following deployment. Methods Both pre- and postdeployment data on 231 of 458 soldiers were analyzed. Postdeployment assessments occurred within 30days from returning stateside and included a battery of psychological health, medical history, and demographic questionnaires; neurocognitive tests; and blood serum for the D2 dopamine receptor (DRD2), apolipoprotein E (APOE), and brain-derived neurotropic factor (BDNF) genes. Results Soldiers who screened positive for traumatic stress at postdeployment had significantly higher scores in depression (d=1.91), anxiety (d=1.61), poor sleep quality (d=0.92), postconcussion symptoms (d=2.21), alcohol use (d=0.63), traumatic life events (d=0.42), and combat exposure (d=0.91). BDNF Val66 Met genotype was significantly associated with risk for sustaining a mild traumatic brain injury (mTBI) and screening positive for traumatic stress. Predeployment traumatic stress, greater combat exposure and sustaining an mTBI while deployed, and the BDNF Met/Met genotype accounted for 22% of the variance of postdeployment PTSD scores (R-2=0.22, P<0.001). However, predeployment traumatic stress, alone, accounted for 17% of the postdeployment PTSD scores. Conclusion These findings suggest predeployment traumatic stress, genetic, and environmental factors have unique contributions to the development of combat-related traumatic stress in military service members. C1 [Dretsch, Michael N.] US Army, Aeromed Res Lab, 6901 Farrel Rd, Ft Rucker, AL USA. [Dretsch, Michael N.; Williams, Kathy] Walter Reed Natl Mil Med Ctr, Natl Intrepid Ctr Excellence, 4860 South Palmer Rd, Bethesda, MD 20889 USA. [Dretsch, Michael N.] Headquarters Army Training & Doctrine Command HQ, Human Dimens Div, 950 Jefferson Ave, Ft Eustis, VA 23604 USA. [Emmerich, Tanja; Crynen, Gogce; Ait-Ghezala, Ghania; Chaytow, Helena; Mathura, Venkat; Crawford, Fiona C.] Roskamp Inst, 2040 Whitfield Ave, Sarasota, FL 34243 USA. [Iverson, Grant L.] Harvard Univ, Sch Med, Dept Phys Med & Rehabil, Boston, MA USA. [Iverson, Grant L.] Spaulding Rehabil Hosp, Boston, MA USA. [Iverson, Grant L.] Red Sox Fdn, Boston, MA USA. [Iverson, Grant L.] Massachusetts Gen Hosp, Home Base Program, Boston, MA 02114 USA. [Iverson, Grant L.] Def & Vet Brain Injury Ctr, Bethesda, MD USA. [Iverson, Grant L.] Harvard Univ, Sch Med, Ctr Hlth & Rehabil, Dept Phys Med & Rehabil, 79-96 Thirteenth St, Charlestown, MA 02129 USA. RP Dretsch, MN (reprint author), HQ TRADOC, Human Dimens Div, 950 Jefferson Ave, Ft Eustis, VA USA. EM michael.n.dretsch.mil@mail.mil FU US Army Medical Research and Materiel Command FX Funding for this study was provided by the US Army Medical Research and Materiel Command. NR 65 TC 2 Z9 2 U1 3 U2 13 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 2162-3279 J9 BRAIN BEHAV JI Brain Behav. PD JAN PY 2016 VL 6 IS 1 AR e00392 DI 10.1002/brb3.392 PG 12 WC Behavioral Sciences; Neurosciences SC Behavioral Sciences; Neurosciences & Neurology GA DB8OV UT WOS:000368777200006 PM 27110438 ER PT J AU Johnson, PC Roberts, AD Hire, JM Mueller, TL AF Johnson, Peter C. Roberts, Aaron D. Hire, Justin M. Mueller, Terry L. TI The Effect of Instrumentation on Suture Tensile Strength and Knot Pullout Strength of Common Suture Materials SO JOURNAL OF SURGICAL EDUCATION LA English DT Article DE knot security; suture strength; suture material AB OBJECTIVE: To determine the effect of instrumentation of suture material on knot security and tensile strength. STUDY DESIGN: In all, 5 types of suture material were used; 10 knots were tied without any instrumentation and 10 knots were tied with a hemostat holding tension on the first throw while the second throw was made for each suture type. Each group was tested to failure with the maximum load and mode of failure recorded. The maximum load between groups of each suture type was compared; frequency of failure through knot slippage vs material fracture was also compared between groups. RESULTS: There was no significant difference observed in the maximum load to failure for any suture type between instrumented and noninstrumented groups. Additionally, there was no difference between any instrumented and noninstrumented groups for material failure vs failure due to knot slippage. CONCLUSIONS: Instrumentation of suture material during two-hand tying does not affect the strength of suture material or knot security. (Published by Elsevier Inc on behalf of the Association of Program Directors in Surgery) C1 [Johnson, Peter C.; Roberts, Aaron D.; Hire, Justin M.; Mueller, Terry L.] Dwight D Eisenhower Army Med Ctr, Dept Orthopaed Surg, Ft Gordon, GA USA. [Johnson, Peter C.; Roberts, Aaron D.; Hire, Justin M.; Mueller, Terry L.] Dwight D Eisenhower Army Med Ctr, Dept Clin Invest, Ft Gordon, GA USA. RP Johnson, PC (reprint author), Dept Orthopaed Surg, 300 East Hosp Rd, Ft Gordon, GA 30905 USA. EM peter.c.johnson.mil@mail.mil FU Department of Clinical Investigation, Dwight D. Eisenhower Army Medical Center; DCI FX Funding for the purchase of suture materials was provided by the Department of Clinical Investigation, Dwight D. Eisenhower Army Medical Center. DCI provided the funding with the intention of generating an article for publication, and provided facilities and equipment for data collection. DCI had no role in study design, or in data analysis or interpretation. NR 6 TC 0 Z9 0 U1 1 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1931-7204 EI 1878-7452 J9 J SURG EDUC JI J. Surg. Educ. PD JAN-FEB PY 2016 VL 73 IS 1 BP 162 EP 165 DI 10.1016/j.jsurg.2015.08.011 PG 4 WC Education, Scientific Disciplines; Surgery SC Education & Educational Research; Surgery GA DB2BR UT WOS:000368313800024 PM 26422001 ER PT J AU Hourani, L Williams, J Bray, RM Wilk, JE Hoge, CW AF Hourani, Laurel Williams, Jason Bray, Robert M. Wilk, Joshua E. Hoge, Charles W. TI Gender Differences in Posttraumatic Stress Disorder and Help Seeking in the US Army SO JOURNAL OF WOMENS HEALTH LA English DT Article ID POSTDEPLOYMENT MENTAL-HEALTH; SERVICE UTILIZATION; MILITARY PERSONNEL; CARE UTILIZATION; PTSD SYMPTOMS; VETERANS; IRAQ; COMBAT; AFGHANISTAN; DUTY AB Background: Inconsistent findings between studies of gender differences in mental health outcomes in military samples have left open questions of differential prevalence in posttraumatic stress disorder (PTSD) among all United States Army soldiers and in differential psychosocial and comorbid risk and protective factor profiles and their association with receipt of treatment. Methods: This study assesses the prevalence and risk factors of screening positive for PTSD for men and women based on two large, population-based Army samples obtained as part of the 2005 and 2008 U.S. Department of Defense Surveys of Health Related Behaviors among Active Duty Military Personnel. Results: The study showed that overall rates of PTSD, as measured by several cutoffs of the PTSD Checklist, are similar between active duty men and women, with rates increasing in both men and women between the two study time points. Depression and problem alcohol use were strongly associated with a positive PTSD screen in both genders, and combat exposure was significantly associated with a positive PTSD screen in men. Overall, active duty men and women who met criteria for PTSD were equally likely to receive mental health counseling or treatment, though gender differences in treatment receipt varied by age, race, social support (presence of spouse at duty station), history of sexual abuse, illness, depression, alcohol use, and combat exposure. Conclusions: The study demonstrates that the prevalence of PTSD as well as the overall utilization of mental health services is similar for active duty men compared with women. However, there are significant gender differences in predictors of positive PTSD screens and receipt of PTSD treatment. C1 [Hourani, Laurel; Williams, Jason; Bray, Robert M.] RTI Int, Res Triangle Pk, NC USA. [Wilk, Joshua E.; Hoge, Charles W.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci Res, Silver Spring, MD USA. RP Hourani, L (reprint author), RTI Int, 3040 Cornwallis Dr, Res Triangle Pk, NC USA. EM Hourani@rti.org FU U.S. Army [W81XWH-10-F-0444] FX This research was supported by contract number W81XWH-10-F-0444 from the U.S. Army. This article represents the views of the authors and is not an official position of the U.S. Army. The authors thank Mr. Justin Faerber and Anne Gering for their editorial assistance. NR 38 TC 2 Z9 2 U1 4 U2 24 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1540-9996 EI 1931-843X J9 J WOMENS HEALTH JI J. Womens Health PD JAN 1 PY 2016 VL 25 IS 1 BP 22 EP 31 DI 10.1089/jwh.2014.5078 PG 10 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Obstetrics & Gynecology; Women's Studies SC Public, Environmental & Occupational Health; General & Internal Medicine; Obstetrics & Gynecology; Women's Studies GA DB4YX UT WOS:000368520700006 PM 26562624 ER PT J AU Molgaard, JJ Auxier, JD Giminaro, AV Oldham, CJ Gill, J Hall, HL AF Molgaard, Joshua J. Auxier, John D., II Giminaro, Andrew V. Oldham, Colton J. Gill, Jonathan Hall, Howard L. TI Production of Synthetic Nuclear Melt Glass SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS LA English DT Article DE Engineering; Issue 107; nuclear weapons; nuclear debris; melt glass; trinitite; vitrify; amorphous; crystalline ID DEBRIS; WASTE AB Realistic surrogate nuclear debris is needed within the nuclear forensics community to test and validate post-detonation analysis techniques. Here we outline a novel process for producing bulk surface debris using a high temperature furnace. The material developed in this study is physically and chemically similar to trinitite (the melt glass produced by the first nuclear test). This synthetic nuclear melt glass is assumed to be similar to the vitrified material produced near the epicenter (ground zero) of any surface nuclear detonation in a desert environment. The process outlined here can be applied to produce other types of nuclear melt glass including that likely to be formed in an urban environment. This can be accomplished by simply modifying the precursor matrix to which this production process is applied. The melt glass produced in this study has been analyzed and compared to trinitite, revealing a comparable crystalline morphology, physical structure, void fraction, and chemical composition. C1 [Molgaard, Joshua J.] US Mil Acad, Dept Phys & Nucl Engn, West Point, NY 10996 USA. [Auxier, John D., II; Giminaro, Andrew V.; Oldham, Colton J.; Gill, Jonathan; Hall, Howard L.] Univ Tennessee, Dept Nucl Engn, Knoxville, TN 37996 USA. [Auxier, John D., II; Giminaro, Andrew V.; Hall, Howard L.] Univ Tennessee, Radiochem Ctr Excellence RCoE, Knoxville, TN 37996 USA. [Hall, Howard L.] Univ Tennessee, Inst Nucl Secur, Knoxville, TN 37996 USA. RP Molgaard, JJ (reprint author), US Mil Acad, Dept Phys & Nucl Engn, West Point, NY 10996 USA. EM Joshua.Molgaard@usma.edu OI Hall, Howard/0000-0002-4080-5159; Auxier II, John /0000-0001-6234-6451 FU Stewardship Science Academic Alliances (SSAA) Program of the National Nuclear Security Administration (NNSA) [DE-NA0001983] FX This work was performed under grant number DE-NA0001983 from the Stewardship Science Academic Alliances (SSAA) Program of the National Nuclear Security Administration (NNSA). NR 23 TC 0 Z9 0 U1 0 U2 5 PU JOURNAL OF VISUALIZED EXPERIMENTS PI CAMBRIDGE PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA SN 1940-087X J9 JOVE-J VIS EXP JI J. Vis. Exp. PD JAN PY 2016 IS 107 AR e53473 DI 10.3791/53473 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DB5TV UT WOS:000368577400027 ER PT S AU Slipher, GA Haynes, RA Riddick, JC AF Slipher, Geoffrey A. Haynes, Robert A. Riddick, Jaret C. BE Ralph, C Silberstein, M Thakre, PR Singh, R TI Electrical Impedance Spectroscopy for Structural Health Monitoring SO MECHANICS OF COMPOSITE AND MULTIFUNCTIONAL MATERIALS, VOL 7 SE Conference Proceedings of the Society for Experimental Mechanics Series LA English DT Proceedings Paper CT Annual Conference and Exposition of Society-for-Experimental-Mechanics on Experimental and Applied Mechanics CY JUN 08-11, 2015 CL Costa Mesa, CA SP Soc Experimental Mech DE Electrical impedance spectroscopy; Structural health monitoring; Carbon fiber; Fatigue state; Damage state detection; Load state detection ID DAMAGE DETECTION; COMPOSITES AB In-situ structural health monitoring systems on vehicles have the potential to enable on-demand material state awareness capability and eliminate the need for lengthy and costly down-times. Further, the information collected from a structural health monitoring system can be used to predict the remaining useful life of a structure or component. Electrical impedance spectroscopy is an emerging method of interrogating carbon fiber reinforced polymer composite materials subject to cyclic loading to determine the current damage state. This technique has the benefit of using the composite itself as the sensing material, thereby not requiring additional sensing material be placed into the composite. Information can be extracted from changes in both the phase and the impedance magnitude of the signal. Previous work found that special care must be taken to ensure that damage to the leads does not affect the results. In this work, a single interrogation path is examined to determine the usefulness of the single-path approach and the nature of the changes in impedance as they relate to fatigue life. C1 [Slipher, Geoffrey A.; Haynes, Robert A.; Riddick, Jaret C.] US Army, Res Lab, Vehicle Technol Directorate, 4603 Flare Loop, Aberdeen Proving Ground, MD 21005 USA. RP Haynes, RA (reprint author), US Army, Res Lab, Vehicle Technol Directorate, 4603 Flare Loop, Aberdeen Proving Ground, MD 21005 USA. EM robert.a.haynes43.civ@mail.mil NR 10 TC 1 Z9 1 U1 4 U2 4 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SN 2191-5644 BN 978-3-319-21762-8; 978-3-319-21761-1 J9 C PROC SOC EXP MECH PY 2016 BP 41 EP 48 DI 10.1007/978-3-319-21762-8_5 PG 8 WC Engineering, Mechanical; Materials Science, Multidisciplinary SC Engineering; Materials Science GA BE1SW UT WOS:000368488900005 ER PT S AU Li, WL Brown, EN Rae, PJ Gazonas, G Negahban, M AF Li, Wenlong Brown, Eric N. Rae, Philip J. Gazonas, George Negahban, Mehrdad BE Ralph, C Silberstein, M Thakre, PR Singh, R TI Mechanical Characterization and Preliminary Modeling of PEEK SO MECHANICS OF COMPOSITE AND MULTIFUNCTIONAL MATERIALS, VOL 7 SE Conference Proceedings of the Society for Experimental Mechanics Series LA English DT Proceedings Paper CT Annual Conference and Exposition of Society-for-Experimental-Mechanics on Experimental and Applied Mechanics CY JUN 08-11, 2015 CL Costa Mesa, CA SP Soc Experimental Mech DE Poly-ether-ether-ketone (PEEK); Equilibrium stress; Plastic flow; Anisotropic elasticity; Mechanical modeling ID GLASSY POLYCARBONATE; ANISOTROPIES; EVOLUTION; SHEAR AB Poly-ether-ether-ketone (PEEK) is a high-performance semi-crystalline polymer with mechanical and thermal stability characteristics that are superior to most tough polymers. The mechanical characteristics of this polymer are modeled over a broad range of mechanical loading conditions using a thermodynamically consistent modeling process. This preliminary model, which ignores the thermal response and the possible recrystallization of this material during loading, shows an outstanding ability to capture the multidimensional nonlinear response of PEEK up to 60 % compression, with loading rates from 0.0001 to 3000 1/s at room temperature. The model includes the measured anisotropy in the wave response that develops with plastic flow, captures the evolution of the measured equilibrium stress, and correctly matches the evolution of the tangent modulus at equilibrium. This broad range of rates and experimental conditions are achieved by using a two-element nonlinear thermodynamically-consistent model. C1 [Li, Wenlong; Negahban, Mehrdad] Univ Nebraska, Mech & Mat Engn, Lincoln, NE 68588 USA. [Brown, Eric N.; Rae, Philip J.] Los Alamos Natl Lab, POB 1663, Los Alamos, NM 87545 USA. [Gazonas, George] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Negahban, M (reprint author), Univ Nebraska, Mech & Mat Engn, Lincoln, NE 68588 USA. EM mnegahban@unl.edu OI Brown, Eric/0000-0002-6812-7820 NR 15 TC 0 Z9 0 U1 3 U2 8 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SN 2191-5644 BN 978-3-319-21762-8; 978-3-319-21761-1 J9 C PROC SOC EXP MECH PY 2016 BP 209 EP 218 DI 10.1007/978-3-319-21762-8_25 PG 10 WC Engineering, Mechanical; Materials Science, Multidisciplinary SC Engineering; Materials Science GA BE1SW UT WOS:000368488900025 ER PT S AU Pankow, M McWilliams, BA AF Pankow, Mark McWilliams, Brandon A. BE Ralph, C Silberstein, M Thakre, PR Singh, R TI Simulation of High Rate Failure Mechanisms in Composites During Quasi-static Testing SO MECHANICS OF COMPOSITE AND MULTIFUNCTIONAL MATERIALS, VOL 7 SE Conference Proceedings of the Society for Experimental Mechanics Series LA English DT Proceedings Paper CT Annual Conference and Exposition of Society-for-Experimental-Mechanics on Experimental and Applied Mechanics CY JUN 08-11, 2015 CL Costa Mesa, CA SP Soc Experimental Mech DE Composites; Penetration mechanics; Dynamic failure mechanisms; High strain rate behavior ID WOVEN COMPOSITES; STRAIN-RATE AB High Rate testing is often difficult to perform, requires specialized equipment and often had results that are difficult to interpret. Being able to simulate the same failure mechanisms at high rates would enable rapid material selection. In this experimental investigation, the mechanical response is determined of different hybrid composites materials. A modified through-the-thickness tests has been used to force a high order of failure mode that is similar to those seen in high speed impact. Failure is observed in the samples and stresses on the surface are determine to help with failure envelope measurements. The details of a comparison between 2D fabrics vs. 3D woven fabrics has been under taken and a comparison will be presented showing the similarities and differences in response. A discussion of the comparison between the high rate testing and the low-rate testing will be investigated and discussion on the applications of the testing will be examined for failure envelope prediction. C1 [Pankow, Mark] N Carolina State Univ, Dept Mech & Aerosp Engn, Raleigh, NC 27695 USA. [McWilliams, Brandon A.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Pankow, M (reprint author), N Carolina State Univ, Dept Mech & Aerosp Engn, Raleigh, NC 27695 USA. EM mrpankow@ncsu.edu NR 7 TC 0 Z9 0 U1 2 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SN 2191-5644 BN 978-3-319-21762-8; 978-3-319-21761-1 J9 C PROC SOC EXP MECH PY 2016 BP 445 EP 450 DI 10.1007/978-3-319-21762-8_52 PG 6 WC Engineering, Mechanical; Materials Science, Multidisciplinary SC Engineering; Materials Science GA BE1SW UT WOS:000368488900052 ER PT S AU McWilliams, BA Yu, JH Pankow, M AF McWilliams, Brandon A. Yu, Jian H. Pankow, Mark BE Bossuyt, S Schajer, G Carpinteri, A TI Dynamic Failure Mechanisms in Woven Ceramic Fabric Reinforced Metal Matrix Composites During Ballistic Impact SO RESIDUAL STRESS, THERMOMECHANICS & INFRARED IMAGING, HYBRID TECHNIQUES AND INVERSE PROBLEMS, VOL 9 SE Conference Proceedings of the Society for Experimental Mechanics Series LA English DT Proceedings Paper CT Annual Conference and Exposition of Society-for-Experimental-Mechanics on Experimental and Applied Mechanics CY JUN 08-11, 2015 CL Costa Mesa, CA SP Soc Experimental Mech DE Metal matrix composites; Penetration mechanics; Dynamic failure mechanisms; Failure modeling; High strain rate behavior ID ALUMINUM AB The complex interaction of dynamic stress waves during ballistic impact provides the opportunity to simultaneously observe the high strain rate loading response under various triaxialities including tension, compression, and shear. In this work the dynamic failure mechanisms of woven ceramic fabric reinforced aluminum metal matrix composites (MMC) during ballistic impact are experimentally investigated. In addition to experimental characterization, an orthotropic elastic-plastic constitutive model with hydrostatic pressure dependent yield is implemented in an explicit finite element code to quantify the stress states present during the progressive damage and failure of the MMC during the penetration and perforation process. C1 [McWilliams, Brandon A.; Yu, Jian H.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Pankow, Mark] N Carolina State Univ, Dept Mech & Aerosp Engn, Raleigh, NC 27695 USA. RP McWilliams, BA (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM brandon.a.mcwilliams.civ@mail.mil NR 15 TC 0 Z9 0 U1 3 U2 5 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SN 2191-5644 BN 978-3-319-21765-9; 978-3-319-21764-2 J9 C PROC SOC EXP MECH PY 2016 BP 155 EP 159 DI 10.1007/978-3-319-21765-9_20 PG 5 WC Engineering, Mechanical; Materials Science, Multidisciplinary; Mechanics SC Engineering; Materials Science; Mechanics GA BE1SX UT WOS:000368490000020 ER PT S AU Yu, JH McWilliams, BA Kaste, RP AF Yu, Jian H. McWilliams, Brandon A. Kaste, Robert P. BE Bossuyt, S Schajer, G Carpinteri, A TI Digital Image Correlation Analysis and Numerical Simulation of the Aluminum Alloys under Quasi-static Tension after Necking Using the Bridgman's Method SO RESIDUAL STRESS, THERMOMECHANICS & INFRARED IMAGING, HYBRID TECHNIQUES AND INVERSE PROBLEMS, VOL 9 SE Conference Proceedings of the Society for Experimental Mechanics Series LA English DT Proceedings Paper CT Annual Conference and Exposition of Society-for-Experimental-Mechanics on Experimental and Applied Mechanics CY JUN 08-11, 2015 CL Costa Mesa, CA SP Soc Experimental Mech DE Bridgman's correction; Digital image correlation; Necking; FEM; Tensile; Stress-strain AB The Bridgman method of true stress correction in tensile loading is revisited. With the current advances in 3D DIC technique, the implementation of the Bridgman method becomes very simple. The equivalent true stress-strain relation from the correction is readily and directly implementable into FEM simulation. The Bridgman method can yield a high degree of accuracy in predicting flow stress in post-necking for some aluminum alloys, especially where the radius of curvature around the neck is small before failure. However, if the actual triaxiality deviates too much from the uniaxial assumption that it is constant across the neck radius, the Bridgman's correction would still over estimate the equivalent stress. Subsequent FEM simulation can determine whether the Bridgman's correction is adequate to predict the true stress-strain relation beyond necking. C1 [Yu, Jian H.; McWilliams, Brandon A.; Kaste, Robert P.] Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Yu, JH (reprint author), Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM jian.h.yu.civ@mail.mil NR 3 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SN 2191-5644 BN 978-3-319-21765-9; 978-3-319-21764-2 J9 C PROC SOC EXP MECH PY 2016 BP 161 EP 166 DI 10.1007/978-3-319-21765-9_21 PG 6 WC Engineering, Mechanical; Materials Science, Multidisciplinary; Mechanics SC Engineering; Materials Science; Mechanics GA BE1SX UT WOS:000368490000021 ER PT J AU Stapanian, MA Lewis, TE Palmer, CJ Amos, MM AF Stapanian, Martin A. Lewis, Timothy E. Palmer, Craig J. Amos, Molly M. TI Assessing accuracy and precision for field and laboratory data: a perspective in ecosystem restoration SO RESTORATION ECOLOGY LA English DT Review DE accuracy; ecosystem restoration; field calibration; precision; QA/QC ID MULTIVARIATE ENVIRONMENTAL DATA; LAKE-ERIE; 2 TESTS; SCALE; REPEATABILITY; ASSESSMENTS; DISTURBANCE; INTEGRITY; OUTLIERS; QUALITY AB Unlike most laboratory studies, rigorous quality assurance/quality control (QA/QC) procedures may be lacking in ecosystem restoration (ecorestoration) projects, despite legislative mandates in the United States. This is due, in part, to ecorestoration specialists making the false assumption that some types of data (e.g. discrete variables such as species identification and abundance classes) are not subject to evaluations of data quality. Moreover, emergent behavior manifested by complex, adapting, and nonlinear organizations responsible for monitoring the success of ecorestoration projects tend to unconsciously minimize disorder, QA/QC being an activity perceived as creating disorder. We discuss similarities and differences in assessing precision and accuracy for field and laboratory data. Although the concepts for assessing precision and accuracy of ecorestoration field data are conceptually the same as laboratory data, the manner in which these data quality attributes are assessed is different. From a sample analysis perspective, a field crew is comparable to a laboratory instrument that requires regular recalibration, with results obtained by experts at the same plot treated as laboratory calibration standards. Unlike laboratory standards and reference materials, the true value for many field variables is commonly unknown. In the laboratory, specific QA/QC samples assess error for each aspect of the measurement process, whereas field revisits assess precision and accuracy of the entire data collection process following initial calibration. Rigorous QA/QC data in an ecorestoration project are essential for evaluating the success of a project, and they provide the only objective legacy of the dataset for potential legal challenges and future uses. C1 [Stapanian, Martin A.] US Geol Survey, Great Lakes Sci Ctr, Lake Erie Biol Stn, 6100 Columbus Ave, Sandusky, OH 44870 USA. [Lewis, Timothy E.] US Army Corps Engn, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. [Palmer, Craig J.; Amos, Molly M.] CSC, 6361 Walker Lane, Alexandria, VA 22310 USA. RP Stapanian, MA (reprint author), US Geol Survey, Great Lakes Sci Ctr, Lake Erie Biol Stn, 6100 Columbus Ave, Sandusky, OH 44870 USA. EM mstapanian@usgs.gov OI Stapanian, Martin/0000-0001-8173-4273 FU U.S. Environmental Protection Agency [EP-C-12-008] FX We thank two anonymous reviewers and the editor for comments on the original submission. J. Aron, H. Clavien, A. Friona, L. Walker, and M. Loomis reviewed previous drafts. L. Blume provided valuable suggestions, comments, and encouragement. Any use of trade, product, or firm names is for descriptive purposes only and does not imply endorsement by the U.S. government. This article is Contribution Number 1970 of the U.S. Geological Survey Great Lakes Science Center. Some of the information in this document has been funded by the U.S. Environmental Protection Agency under contract number EP-C-12-008 to CSC. Although some of the research described in this article has been funded by the U.S. Environmental Protection Agency, it has not been subjected to Agency review. Any opinions expressed in this publication are those of the author(s) and do not, necessarily, reflect the official positions and policies of the U.S. EPA. Any mention of products or trade names does not constitute recommendation for use by the U.S. EPA. NR 66 TC 1 Z9 1 U1 2 U2 11 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1061-2971 EI 1526-100X J9 RESTOR ECOL JI Restor. Ecol. PD JAN PY 2016 VL 24 IS 1 BP 18 EP 26 DI 10.1111/rec.12284 PG 9 WC Ecology SC Environmental Sciences & Ecology GA DB6QB UT WOS:000368638700004 ER PT J AU Kreyer, S Scaravilli, V Linden, K Belenkiy, SM Necsoiu, C Li, YS Putensen, C Chung, KK Batchinsky, AI Cancio, LC AF Kreyer, Stefan Scaravilli, Vittorio Linden, Katharina Belenkiy, Slava M. Necsoiu, Corina Li, Yansong Putensen, Christian Chung, Kevin K. Batchinsky, Andriy I. Cancio, Leopoldo C. TI EARLY UTILIZATION OF EXTRACORPOREAL CO2 REMOVAL FOR TREATMENT OF ACUTE RESPIRATORY DISTRESS SYNDROME DUE TO SMOKE INHALATION AND BURNS IN SHEEP SO SHOCK LA English DT Article DE Acute respiratory distress syndrome; burns; extracorporeal lung support; mechanical ventilation; smoke inhalation injury ID CARBON-DIOXIDE REMOVAL; EXPERIMENTAL PULMONARY CONTUSION; PRESSURE RELEASE VENTILATION; INTERVENTIONAL LUNG ASSIST; MECHANICAL VENTILATION; MEMBRANE-OXYGENATION; AIRWAY PRESSURE; 6 ML/KG; SYSTEM; INJURY AB Introduction:In thermally injured patients, inhalation injury is often associated with acute respiratory distress syndrome (ARDS), and is an independent predictor of increased morbidity and mortality. Extracorporeal CO2 removal (ECCO2R) therapy offers new possibilities in protective mechanical ventilation in ARDS patients. We performed an early application of ECCO2R in mild-to-moderate ARDS in sheep ventilated in BiPAP mode. Our aim was to investigate its effect on severity of the lung injury.Material and Methods:Non-pregnant farm-bred ewes (n=15) were anesthetized and injured by a combination of wood-bark smoke inhalation and a 40% total body surface area full-thickness burn, and were observed for 72h or death. The animals were randomized to a Hemolung group (n=7) or a Control group (n=8) at time of ARDS onset. ECCO2R was performed in the Hemolung group after onset of ARDS.Histopathology, CT scans, systemic and pulmonary variables, and CO2 removal were examined.Results:Early application of ECCO2R therapy with Hemolung in spontaneously breathing sheep decreased PaCO2 significantly, while the device removed about 70mL of CO2 per minute. This did not result in lower minute ventilation in the Hemolung group. Lungpathology and CT scans did not show a difference between groups.Conclusion:In an ovine model of ARDS due to smoke inhalation and burn injury, early institution of ECCO2R in spontaneously breathing animals was effective in removing CO2 and in reducing PaCO2. However, it had no effect on reducing the severity of lung injury or mortality. Further studies are necessary to detail the interaction between extracorporeal CO2 removal and pulmonary physiology. C1 [Kreyer, Stefan; Putensen, Christian] Univ Hosp Bonn, Dept Anesthesiol & Intens Care Med, D-53125 Bonn, Germany. [Kreyer, Stefan; Scaravilli, Vittorio; Linden, Katharina; Belenkiy, Slava M.; Necsoiu, Corina; Li, Yansong; Chung, Kevin K.; Batchinsky, Andriy I.; Cancio, Leopoldo C.] US Army, Inst Surg Res, JBSA Ft Sam Houston, Killeen, TX USA. [Scaravilli, Vittorio] Univ Milano Bicocca, Dipartimento Sci Salute, Monza, MB, Italy. [Linden, Katharina] Univ Hosp Bonn, Dept Pediat, Bonn, Germany. [Belenkiy, Slava M.] W Virginia Univ, Sch Med, Dept Anesthesiol, Morgantown, WV USA. [Chung, Kevin K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Kreyer, S (reprint author), Univ Hosp Bonn, Dept Anesthesiol & Intens Care Med, D-53125 Bonn, Germany. EM Stefan.Kreyer@uni-bonn.de FU U.S. Department of Energy; U.S. Army Medical Research and Materiel Command; U.S. Army Medical Research and Materiel Command (USAMRMC); Telemedicine and Advanced Technology Research Center (TATRC) [12340055]; Comprehensive Intensive Care Research Task Area, Combat Casualty Care Research Program, U.S. Army Medical Research and Materiel Command, Fort Detrick, MD FX This research was supported in part by appointment of one of the authors (LCC) to the Knowledge Preservation Program at the U.S. Army Institute of Surgical Research, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and the U.S. Army Medical Research and Materiel Command.; This study was funded by U.S. Army Medical Research and Materiel Command (USAMRMC) and the Telemedicine and Advanced Technology Research Center (TATRC) entitled: "Transportable Life Support for Treatment of Acute Lung Failure Due to Smoke Inhalation and Burns", Log No 12340055. Principal Investigator of the study is AIB. As part of this effort Alung Inc., the manufacturer of the Hemolung CO2 removal system, provided membranes and a data monitoring console to conduct the experiments. No other financial support was provided by the company.; Supported by the Comprehensive Intensive Care Research Task Area, Combat Casualty Care Research Program, U.S. Army Medical Research and Materiel Command, Fort Detrick, MD. NR 37 TC 2 Z9 2 U1 2 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JAN PY 2016 VL 45 IS 1 BP 65 EP 72 DI 10.1097/SHK.0000000000000471 PG 8 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA DB4QW UT WOS:000368499200011 PM 26674455 ER PT J AU Netherland, MD Richardson, RJ AF Netherland, Michael D. Richardson, Robert J. TI Evaluating Sensitivity of Five Aquatic Plants to a Novel Arylpicolinate Herbicide Utilizing an Organization for Economic Cooperation and Development Protocol SO WEED SCIENCE LA English DT Article DE Aquatic herbicide; aquatic plant bioassay; aquatic plant toxicity; Beck's water-marigold; herbicide screening; invasive aquatic plants ID EURASIAN WATERMILFOIL; MYRIOPHYLLUM-SPICATUM; HYBRID WATERMILFOIL; TRICLOPYR; FLURIDONE; EXPOSURE; HYDRILLA; EFFICACY; DOCUMENTATION; MACROPHYTES AB New arylpicolinate herbicide chemistry under development for rice, aquatic weed management, and other uses was evaluated using five aquatic plants. The herbicide 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)-5-fluoro-pyridine-2-benzyl ester-also identified as XDE-848 BE or SX-1552 (proposed International Organization for Standardization common name in review; active tradename Rinskor (TM))-and its acid form (XDE-848 acid or SX-1552A) were evaluated on three dicots: (1) Eurasian watermilfoil (EWM), (2) megalodonta, and (3) crested floating heart (CFH), and two monocots: (1) hydrilla and (2) elodea. A small-scale Organization for Economic Cooperation and Development (OECD) protocol developed using EWM for registration studies was utilized. EWM and megalodonta were also evaluated in larger-scale mesocosms for comparison. In-water concentrations between 0.01 and 243 mg ai L-1 as SX-1552 or SX-1552A were applied under static conditions for 14 (growth chamber) or 28 d (mesocosm). EWM was susceptible to both SX-1552 and SX-1552A, with dry-weight 50% effective concentration (EC50) values of 0.11 and 0.23 mu g ai L-1 under growth chamber conditions. Megalodonta had EC50 values of 11.3 and 14.5 mu g ai L-1 for the SX-1552 and SX-1552A. CFH was more sensitive to SX-1552 (EC50 5 5.6 mu g ai L-1) than to SX-1552A (EC50 5 23.9 mu g ai L-1). Hydrilla had EC50 values of 1.4 and 2.5 mu g ai L-1, whereas elodea was more tolerant, with EC50 values of 6.9 and 13.1 mu g ai L-1 for SX-1552 and SX-1552A, respectively. For EWM mesocosm trials, EC50 values for SX-1552 and 1552A were 0.12 mu g ai L-1 and 0.58 mu g ai L-1, whereas the megalodonta EC50 was 6.1 mu g ai L-1. Activity of SX-1552 on EWM, hydrilla, and CFH merits continued investigation for selective aquatic weed control properties. Results suggest that the OECD protocol can be used to screen activity of herbicides for multiple aquatic plant species. C1 [Netherland, Michael D.] US Army Engineer Res & Dev Ctr, Gainesville, FL 32653 USA. N Carolina State Univ, Raleigh, NC 27695 USA. RP Netherland, MD (reprint author), US Army Engineer Res & Dev Ctr, 7922 NW 71st St, Gainesville, FL 32653 USA. EM Michael.D.Netherland@usace.army.mil FU U.S. Army Engineer Research and Development Center; Aquatic Plant Control Research Program; Aquatic Ecosystem Restoration Foundation FX The assistance of Jesse Stevens with study setup and data collection is greatly appreciated. Funding for this project was provided through the U.S. Army Engineer Research and Development Center, Aquatic Plant Control Research Program and through the Aquatic Ecosystem Restoration Foundation. Citation of trade names does not constitute endorsement or approval of the use of such commercial products. Permission to publish this paper was granted by the Chief of Engineers. NR 37 TC 1 Z9 1 U1 3 U2 7 PU WEED SCI SOC AMER PI LAWRENCE PA 810 EAST 10TH ST, LAWRENCE, KS 66044-8897 USA SN 0043-1745 EI 1550-2759 J9 WEED SCI JI Weed Sci. PD JAN-MAR PY 2016 VL 64 IS 1 BP 181 EP 190 DI 10.1614/WS-D-15-00092.1 PG 10 WC Agronomy; Plant Sciences SC Agriculture; Plant Sciences GA DB1IY UT WOS:000368263100021 ER PT J AU Brooks, BW Lazorchak, JM Howard, MDA Johnson, MVV Morton, SL Perkins, DAK Reavie, ED Scott, GI Smith, SA Steevens, JA AF Brooks, Bryan W. Lazorchak, James M. Howard, Meredith D. A. Johnson, Mari-Vaughn V. Morton, Steve L. Perkins, Dawn A. K. Reavie, Euan D. Scott, Geoffrey I. Smith, Stephanie A. Steevens, Jeffery A. TI Are Harmful Algal Blooms Becoming the Greatest Inland Water Quality Threat to Public Health and Aquatic Ecosystems? SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Harmful algae; Climate change; Urbanization; Agriculture; Salinization; Lake and reservoir monitoring; Toxin; Ambient toxicity; Essential services of environmental public health ID PRYMNESIUM-PARVUM BLOOMS; PERSONAL CARE PRODUCTS; CLIMATE-CHANGE; LAKE-ERIE; EUTROPHICATION; CYANOBACTERIA; BIODIVERSITY; ENVIRONMENT; QUESTIONS; IMPACTS AB In this Focus article, the authors ask a seemingly simple question: Are harmful algal blooms (HABs) becoming the greatest inland water quality threat to public health and aquatic ecosystems? When HAB events require restrictions on fisheries, recreation, and drinking water uses of inland water bodies significant economic consequences result. Unfortunately, the magnitude, frequency, and duration of HABs in inland waters are poorly understood across spatiotemporal scales and differentially engaged among states, tribes, and territories. Harmful algal bloom impacts are not as predictable as those from conventional chemical contaminants, for which water quality assessment and management programs were primarily developed, because interactions among multiple natural and anthropogenic factors determine the likelihood and severity to which a HAB will occur in a specific water body. These forcing factors can also affect toxin production. Beyond site-specific water quality degradation caused directly by HABs, the presence of HAB toxins can negatively influence routine surface water quality monitoring, assessment, and management practices. Harmful algal blooms present significant challenges for achieving water quality protection and restoration goals when these toxins confound interpretation of monitoring results and environmental quality standards implementation efforts for other chemicals and stressors. Whether HABs presently represent the greatest threat to inland water quality is debatable, though in inland waters of developed countries they typically cause more severe acute impacts to environmental quality than conventional chemical contamination events. The authors identify several timely research needs. Environmental toxicology, environmental chemistry, and risk-assessment expertise must interface with ecologists, engineers, and public health practitioners to engage the complexities of HAB assessment and management, to address the forcing factors for HAB formation, and to reduce the threats posed to inland surface water quality. (C) 2015 SETAC C1 [Brooks, Bryan W.] Baylor Univ, Dept Environm Sci, Ctr Reservoir & Aquat Syst Res, Inst Biomed Studies, Waco, TX 76798 USA. [Lazorchak, James M.] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA. [Howard, Meredith D. A.] Southern Calif Coastal Water Res Project, Costa Mesa, CA USA. [Johnson, Mari-Vaughn V.] Nat Resources Conservat Serv, USDA, Temple, TX USA. [Morton, Steve L.] NOAA, Natl Ctr Coastal Ocean Sci, Ctr Coastal Environm Hlth & Biomol Res, Charleston, SC USA. [Perkins, Dawn A. K.] Univ Wisconsin, Wisconsin State Lab Hyg, Madison, WI 53706 USA. [Reavie, Euan D.] Univ Minnesota, Nat Resources Res Inst, Ctr Water & Environm, Duluth, MN 55811 USA. [Scott, Geoffrey I.] Univ S Carolina, Arnold Sch Publ Hlth, Dept Environm Hlth Sci, Columbia, SC 29208 USA. [Smith, Stephanie A.] Beagle Bioprod, Columbus, OH USA. [Steevens, Jeffery A.] US Army Engn Res & Dev Ctr, Vicksburg, MS USA. RP Brooks, BW (reprint author), Baylor Univ, Dept Environm Sci, Ctr Reservoir & Aquat Syst Res, Inst Biomed Studies, Waco, TX 76798 USA. EM bryan_brooks@baylor.edu RI Brooks, Bryan/B-2612-2010; Guenat, Heather/H-6528-2014; OI Brooks, Bryan/0000-0002-6277-9852; Lazorchak, James/0000-0002-7354-7571 FU Fulbright Visiting Research Chair in Water and the Environment at the University of Lethbridge, Alberta, Canada FX Permission was granted by the US Army Corps of Engineers chief of engineers to publish this material. The information in this document has been subjected to review by the USEPA, the US Department of Agriculture, and the National Oceanic and Atmospheric Administration and has been approved for publication. The views expressed in this column are those of the authors and do not necessarily represent the views or policies of the USEPA, the US Department of Agriculture, or the National Oceanic and Atmospheric Administration. During the development of this column, B.W. Brooks was supported as the Fulbright Visiting Research Chair in Water and the Environment at the University of Lethbridge, Alberta, Canada, and as a Visiting Erskine Fellow at the University of Canterbury, Christchurch, New Zealand. NR 48 TC 9 Z9 9 U1 52 U2 152 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD JAN PY 2016 VL 35 IS 1 BP 6 EP 13 DI 10.1002/etc.3220 PG 8 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA DA9KI UT WOS:000368127200001 PM 26771345 ER PT J AU Stanley, JK Laird, JG Kennedy, AJ Steevens, JA AF Stanley, Jacob K. Laird, Jennifer G. Kennedy, Alan J. Steevens, Jeffery A. TI SUBLETHAL EFFECTS OF MULTIWALLED CARBON NANOTUBE EXPOSURE IN THE INVERTEBRATE DAPHNIA MAGNA SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Behavioral toxicology; Nanoecotoxicology; Aquatic toxicology; Multiwalled carbon nanotube; Natural organic matter; Aquatic invertebrate ID TITANIUM-DIOXIDE; TOXICITY; GROWTH; REPRODUCTION; MORTALITY; NANOPARTICLES; NANOMATERIALS; BIOASSAYS; FOOD AB Carbon nanotubes were previously demonstrated to accumulate on the carapace and in the gut of daphnids in aquatic exposures. The purpose of the present study was to assess the effects of multiwalled carbon nanotube (MWCNT) exposure on the sublethal Daphnia magna endpoints swimming behavior, algal feeding, growth, and reproduction and to determine the relative magnitude of difference between lethal and sublethal toxicity thresholds in 48-h and 14-d exposures. A stable dispersion of MWCNTs was prepared using 100 mg/L natural organic matter (NOM), and all treatments were compared statistically to a NOM control. The swimming behavior endpoints of mean velocity and total distance moved were determined using digital tracking software. For the acute (48-h) exposure, a 50% lethal concentration (LC50) of 29.3 (23.6-36.3) mg/L and a 50% effective concentration (EC50) of 6.7 mg/L in the swimming velocity endpoint were determined. When swimming response was nonmonotonic below 2 mg/L, consistent reductions in velocity were observed at 6.9 mg/L and above. Median effect concentrations were lower in the chronic (14-d) bioassay. The 14-d LC50 was 4.3 mg/L (3.3-5.6 mg/L), and the reproduction EC50 was 5.0 mg/L. Lowest-observed-effect concentrations for survival and reproduction were 5.4 mg/L and 1.7 mg/L, respectively. Significantly fewer (23.1%) algal cells were consumed in the 3.9-mg/L treatment relative to the control. No significant effects on swimming behavior were observed for the 14-d bioassay. Less traditional sublethal endpoints such as swimming behavior and feeding rate may be especially important to assess for MWCNTs and other materials expected to be more physically than chemically toxic through mechanisms such as gut clogging. Published 2015 Wiley Periodicals Inc. on behalf of SETAC. This article is a US Government work and is in the public domain in the United States of America. C1 [Stanley, Jacob K.; Laird, Jennifer G.; Kennedy, Alan J.; Steevens, Jeffery A.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Stanley, JK (reprint author), US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. EM jacob.k.stanley@us.army.mil FU US Army's Environmental Quality Technology Research Program FX Permission was granted by the chief of engineers to publish the present study. The present study was funded by the US Army's Environmental Quality Technology Research Program (E. Ferguson, Technical Director). NR 26 TC 1 Z9 1 U1 6 U2 29 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD JAN PY 2016 VL 35 IS 1 BP 200 EP 204 DI 10.1002/etc.3184 PG 5 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA DA9KI UT WOS:000368127200024 PM 26222333 ER PT J AU Hoke, R Huggett, D Brasfield, S Brown, B Embry, M Fairbrother, A Kivi, M Paumen, ML Prosser, R Salvito, D Scroggins, R AF Hoke, Robert Huggett, Duane Brasfield, Sandra Brown, Becky Embry, Michelle Fairbrother, Anne Kivi, Michelle Paumen, Miriam Leon Prosser, Ryan Salvito, Dan Scroggins, Rick TI Review of Laboratory-Based Terrestrial Bioaccumulation Assessment Approaches for Organic Chemicals: Current Status and Future Possibilities SO INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT LA English DT Review DE Terrestrial; Bioaccumulation assessment; Chemical regulation; POPs; Wildlife ID PHYSIOLOGICAL PHARMACOKINETIC MODELS; POLYCYCLIC AROMATIC-HYDROCARBONS; NORTHERN BOBWHITE QUAIL; PARTITION-COEFFICIENTS; HUMAN PHARMACEUTICALS; DIFFERENTIAL UPTAKE; ALUMINUM-OXIDE; PLANT UPTAKE; FOOD-CHAINS; FIELD AB In the last decade, interest has been renewed in approaches for the assessment of the bioaccumulation potential of chemicals, principally driven by the need to evaluate large numbers of chemicals as part of new chemical legislation, while reducing vertebrate test organism use called for in animal welfare legislation. This renewed interest has inspired research activities and advances in bioaccumulation science for neutral organic chemicals in aquatic environments. In January 2013, ILSI Health and Environmental Sciences Institute convened experts to identify the state of the science and existing shortcomings in terrestrial bioaccumulation assessment of neutral organic chemicals. Potential modifications to existing laboratory methods were identified, including areas in which new laboratory approaches or test methods could be developed to address terrestrial bioaccumulation. The utility of "non-ecotoxicity" data (e. g., mammalian laboratory data) was also discussed. The highlights of the workshop discussions are presented along with potential modifications in laboratory approaches and new test guidelines that could be used for assessing the bioaccumulation of chemicals in terrestrial organisms. Integr Environ Assess Manag 2016; 12: 109-122. (C) 2015 SETAC C1 [Hoke, Robert] DuPont Co Inc, Haskell Global Centers Hlth & Environm Sci, Newark, DC USA. [Huggett, Duane] Univ N Texas, Denton, TX 76203 USA. [Brasfield, Sandra] US Army, Engn Res & Dev Ctr, Vicksburg, MS USA. [Brown, Becky] AstraZeneca, Global Environm, Chester, Cheshire, England. [Embry, Michelle] LSI HESI, Washington, DC USA. [Fairbrother, Anne] Exponent, Bellevue, WA USA. [Kivi, Michelle] PMRA, Hlth Canada, Ottawa, ON, Canada. [Paumen, Miriam Leon] ExxonMobil Biomed Sci, Machelen, Belgium. [Prosser, Ryan] Univ Guelph, Guelph, ON N1G 2W1, Canada. [Salvito, Dan] RIFM, Woodcliff Lake, NJ USA. [Scroggins, Rick] Environm Canada, Ottawa, ON K1A 0H3, Canada. RP Hoke, R (reprint author), DuPont Co Inc, Haskell Global Centers Hlth & Environm Sci, Newark, DC 94545 USA. EM robert.a.hoke@dupont.com FU International Life Sciences Institute; Health and Environmental Sciences Institute FX We thank the International Life Sciences Institute, Health and Environmental Sciences Institute for sponsoring the "Terrestrial Bioaccumulation Workshop," January 8-10, 2013 in Miami, Florida. MK also specifically acknowledges input from N Kavaslar, M Gerrits, M Beauchamp, C Bowes and R Gangaraju of the Health and Environment Directorates, PMRA. The authors also thank the anonymous reviewers for their review comments which helped improve the manuscript. The authors have no conflicts of interest to declare that affect the publication of this manuscript. NR 115 TC 0 Z9 0 U1 7 U2 26 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1551-3777 EI 1551-3793 J9 INTEGR ENVIRON ASSES JI Integr. Environ. Assess. Manag. PD JAN PY 2016 VL 12 IS 1 BP 109 EP 122 DI 10.1002/ieam.1692 PG 14 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA DA6KV UT WOS:000367914100010 PM 26272585 ER PT J AU van den Brink, NW Arblaster, JA Bowman, SR Conder, JM Elliott, JE Johnson, MS Muir, DCG Natal-da-Luz, T Rattner, BA Sample, BE Shore, RF AF van den Brink, Nico W. Arblaster, Jennifer A. Bowman, Sarah R. Conder, Jason M. Elliott, John E. Johnson, Mark S. Muir, Derek C. G. Natal-da-Luz, Tiago Rattner, Barnett A. Sample, Bradley E. Shore, Richard F. TI Use of Terrestrial Field Studies In the Derivation of Bioaccumulation Potential of Chemicals SO INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT LA English DT Article DE Biomagnification factors; Biota-to-soil-accumulation factors; BMF; BSAF; Chemical bioaccumulation; Terrestrial food web; TMF; Trophic magnification factors ID PERSISTENT ORGANIC POLLUTANTS; BROMINATED FLAME RETARDANTS; TROPHIC MAGNIFICATION FACTORS; POLLUTION EXPOSURE ASSESSMENT; HEDGEHOG ERINACEUS-EUROPAEUS; LICHEN-CARIBOU-WOLF; MARINE FOOD-WEB; BIOMONITORING TOOL; STABLE-ISOTOPES; TEMPORAL TRENDS AB Field-based studies are an essential component of research addressing the behavior of organic chemicals, and a unique line of evidence that can be used to assess bioaccumulation potential in chemical registration programs and aid in development of associated laboratory and modeling efforts. To aid scientific and regulatory discourse on the application of terrestrial field data in this manner, this article provides practical recommendations regarding the generation and interpretation of terrestrial field data. Currently, biota-to-soil-accumulation factors (BSAFs), biomagnification factors (BMFs), and bioaccumulation factors (BAFs) are the most suitable bioaccumulation metrics that are applicable to bioaccumulation assessment evaluations and able to be generated from terrestrial field studies with relatively low uncertainty. Biomagnification factors calculated from field-collected samples of terrestrial carnivores and their prey appear to be particularly robust indicators of bioaccumulation potential. The use of stable isotope ratios for quantification of trophic relationships in terrestrial ecosystems needs to be further developed to resolve uncertainties associated with the calculation of terrestrial trophic magnification factors (TMFs). Sampling efforts for terrestrial field studies should strive for efficiency, and advice on optimization of study sample sizes, practical considerations for obtaining samples, selection of tissues for analysis, and data interpretation is provided. Although there is still much to be learned regarding terrestrial bioaccumulation, these recommendations provide some initial guidance to the present application of terrestrial field data as a line of evidence in the assessment of chemical bioaccumulation potential and a resource to inform laboratory and modeling efforts. Integr Environ Assess Manag 2016; 12: 135-145. (C) 2015 SETAC C1 [van den Brink, Nico W.] Wageningen Univ, Subdept Toxicol, NL-6700 AP Wageningen, Netherlands. [Arblaster, Jennifer A.] Ramba Environ Corp, Irvine, CA USA. [Bowman, Sarah R.] Ohio State Univ, Dept Evolut Ecol & Organismal Biol, Columbus, OH 43210 USA. [Conder, Jason M.] Geosyntec Consultants, Huntington Beach, CA USA. [Elliott, John E.] Environm Canada, Delta, BC, Canada. [Johnson, Mark S.] US Army, Publ Hlth Ctr, Aberdeen, MD USA. [Muir, Derek C. G.] Environm Canada, Burlington, ON, Canada. [Natal-da-Luz, Tiago] Univ Coimbra, Ctr Funct Ecol, Dept Life Sci, Coimbra, Portugal. [Rattner, Barnett A.] US Geol Survey, Patuxent Wildlife Res Ctr, Beltsville, MD USA. [Sample, Bradley E.] Ecol Risk, Rancho Murieta, CA USA. [Shore, Richard F.] NERC, Ctr Ecol & Hydrol, Lancaster, England. RP van den Brink, NW (reprint author), Wageningen Univ, Subdept Toxicol, NL-6700 AP Wageningen, Netherlands. EM nico.vandenbrink@wur.nl RI Shore, Richard/A-2638-2012 OI Shore, Richard/0000-0002-9337-8883 NR 107 TC 1 Z9 1 U1 6 U2 17 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1551-3777 EI 1551-3793 J9 INTEGR ENVIRON ASSES JI Integr. Environ. Assess. Manag. PD JAN PY 2016 VL 12 IS 1 BP 135 EP 145 DI 10.1002/ieam.1717 PG 11 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA DA6KV UT WOS:000367914100012 PM 26436822 ER PT J AU Kwan, J Hoverson, K Arora, NS AF Kwan, Julia Hoverson, Kara Arora, Navin S. TI A scaly eruption on the body SO INTERNATIONAL JOURNAL OF DERMATOLOGY LA English DT Editorial Material ID DERMATITIS NEGLECTA; DERMATOSIS C1 [Kwan, Julia] Naval Hlth Clin Hawaii, Dermatol Serv, Joint Base Pearl Harbor Hickham, Honolulu, HI USA. [Hoverson, Kara] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Arora, Navin S.] Tripler Army Med Ctr, Dermatol Serv, Honolulu, HI 96859 USA. RP Hoverson, K (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM Kara.hoverson@gmail.com NR 6 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0011-9059 EI 1365-4632 J9 INT J DERMATOL JI Int. J. Dermatol. PD JAN PY 2016 VL 55 IS 1 BP E4 EP E6 DI 10.1111/ijd.13063 PG 3 WC Dermatology SC Dermatology GA DA8XG UT WOS:000368089600002 PM 26463106 ER PT J AU Pollett, S Leguia, M Nelson, MI Berry, IM Rutherford, G Bausch, DG Kasper, M Jarman, R Melendrez, M AF Pollett, S. Leguia, M. Nelson, M. I. Berry, I. Maljkovic Rutherford, G. Bausch, D. G. Kasper, M. Jarman, R. Melendrez, M. TI Feasibility and effectiveness of a brief, intensive phylogenetics workshop in a middle-income country SO INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE Phylogenetics; Bioinformatics; Training; Low- and middle-income country; Viral pathogens ID PHYLOGEOGRAPHY; VIRUS AB There is an increasing role for bioinformatic and phylogenetic analysis in tropical medicine research. However, scientists working in low- and middle-income regions may lack access to training opportunities in these methods. To help address this gap, a 5-day intensive bioinformatics workshop was offered in Lima, Peru. The syllabus is presented here for others who want to develop similar programs. To assess knowledge gained, a 20-point knowledge questionnaire was administered to participants (21 participants) before and after the workshop, covering topics on sequence quality control, alignment/formatting, database retrieval, models of evolution, sequence statistics, tree building, and results interpretation. Evolution/tree-building methods represented the lowest scoring domain at baseline and after the workshop. There was a considerable median gain in total knowledge scores (increase of 30%, p < 0.001) with gains as high as 55%. A 5-day workshop model was effective in improving the pathogen-applied bioinformatics knowledge of scientists working in a middle-income country setting. (C) 2015 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. C1 [Pollett, S.; Leguia, M.; Bausch, D. G.] US Naval Med Res Unit 6, Lima, Peru. [Pollett, S.; Rutherford, G.] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA. [Pollett, S.] Univ Sydney, Marie Bashir Inst Infect Dis & Biosecur, Sydney, NSW 2006, Australia. [Nelson, M. I.] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. [Berry, I. Maljkovic; Jarman, R.; Melendrez, M.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Kasper, M.] Armed Forces Hlth Surveillance Ctr, Global Emerging Infect Surveillance & Response Sy, Silver Spring, MD USA. RP Pollett, S (reprint author), US Naval Med Res Unit 6, Lima, Peru. EM spollett@med.usyd.edu.au OI Melendrez, Melanie/0000-0002-4811-4467 FU Global Emerging Infections Surveillance and Response System (GEIS), a division of the Armed Forces Health Surveillance Center (AFHSC) FX The authors thank Ana Sofia Rengifo and the Universidad Peruana Cayetano Heredia for their assistance. This work was supported by the Global Emerging Infections Surveillance and Response System (GEIS), a division of the Armed Forces Health Surveillance Center (AFHSC). NR 9 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1201-9712 EI 1878-3511 J9 INT J INFECT DIS JI Int. J. Infect. Dis. PD JAN PY 2016 VL 42 BP 24 EP 27 DI 10.1016/j.ijid.2015.11.001 PG 4 WC Infectious Diseases SC Infectious Diseases GA DA8FK UT WOS:000368040300006 PM 26571303 ER PT J AU Cuda, JP Shearer, JF Weeks, ENI Kariuki, E Baniszewski, J Giurcanu, M AF Cuda, James P. Shearer, Judy F. Weeks, Emma N. I. Kariuki, Eutychus Baniszewski, Julie Giurcanu, Mihai TI Compatibility of an insect, a fungus, and a herbicide for integrated pest management of dioecious hydrilla SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article DE Cricotopus lebetis; herbicide-resistance management; Hydrilla verticillata; imazamox; integrated weed management; Mycoleptodiscus terrestris ID CRICOTOPUS-LEBETIS DIPTERA; BIOLOGICAL-CONTROL AGENT; VERTICILLATA HYDROCHARITACEAE; NORTH-AMERICA; AQUATIC WEED; TIP MINER; CHIRONOMIDAE; FLURIDONE; PATHOGEN; MACROPHYTES AB During the past 15 yr dioecious hydrilla (Hydrilla verticillata) in Florida developed resistance to fluridone and endothall, two registered herbicides approved for aquatic use. An integrated pest management approach could mitigate the effects of herbicide resistance and improve the sustainability of dioecious hydrilla management in Florida. In this study, we tested a reduced-risk method for dioecious hydrilla control by integrating selective insect herbivory with a disease organism or low concentrations of a new herbicide recently registered for aquatic use. Two rates of the fungal pathogen Mycoleptodiscus terrestris (Mt) and the acetolactate synthase-inhibiting herbicide imazamox, and two densities of the hydrilla tipmining midge Cricotopus lebetis alone and in combination were randomly applied to aquaria containing established hydrilla plants and replicated three times. Hydrilla shoots in each tank were harvested,similar to 30 d after the treatments were applied. Hydrilla biomass produced in each treatment was compared. Results showed that combining the hydrilla tipmining midge C. lebetis with either the Mt fungus or herbicide imazamox significantly reduced hydrilla growth and the effects in some treatments were synergistic. Furthermore, C. lebetis was compatible with the herbicide imazamox; adult emergence of C. lebetis was similar in aquaria treated with imazamox compared with untreated controls. Incorporating biological control agents like Mt and the tip-mining midge C. lebetis into an integrated weed-management strategy could reduce overreliance on herbicides and provide a more sustainable solution to Florida's dioecious hydrilla problem. C1 [Cuda, James P.; Weeks, Emma N. I.; Baniszewski, Julie] Univ Florida, Dept Entomol & Nematol, Gainesville, FL 32611 USA. [Shearer, Judy F.] US Army Engineer Res 8c Dev Ctr, Environm Lab, Waterways Expt Stn, Vicksburg, MS 39180 USA. [Giurcanu, Mihai] Univ Florida, IFAS Stat, Gainesville, FL 32611 USA. RP Cuda, JP (reprint author), Univ Florida, Dept Entomol & Nematol, Gainesville, FL 32611 USA. EM jcuda@ufl.edu FU National Institute of Food and Agriculture, U.S. Department of Agriculture [2010-02825]; Weed Science Society of America (Undergraduate Research Award) FX We thank Jan Freedman, Verena-Ulrike Lietze, Alissa Berro, and Karen Stratman for their technical support. We also thank Bill Overholt, Lyn Gettys, and Mike Netherland for their comments on an earlier draft of this manuscript. This material is based upon work that is supported by the National Institute of Food and Agriculture, U.S. Department of Agriculture, under award number 2010-02825, and the Weed Science Society of America (Undergraduate Research Award). NR 56 TC 0 Z9 0 U1 7 U2 20 PU AQUATIC PLANT MANAGEMENT SOC, INC PI VICKSBURG PA PO BOX 821265, VICKSBURG, MS 39182 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JAN PY 2016 VL 54 BP 20 EP 25 PG 6 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA DA7DP UT WOS:000367965100003 ER PT J AU Richardson, RJ Haug, EJ Netherland, MD AF Richardson, Robert J. Haug, Erika J. Netherland, Michael D. TI Response of seven aquatic plants to a new arylpicolinate herbicide SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article DE herbicidal control; synthetic auxin ID WATERMILFOIL MYRIOPHYLLUM-SPICATUM; EURASIAN WATERMILFOIL; HYBRID WATERMILFOIL; TRICLOPYR; RESISTANCE; FLURIDONE; AUXIN; SIBIRICUM; HYDRILLA; EFFICACY AB The herbicide 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)-5-fluoro-pyridine-2-benzyl ester (SX-1552 or XDE-848 BE; proposed ISO common name in review) is a new arylpicolinate herbicide currently under development for weed management in rice (Oryza sativa L.) production, aquatic weed management, and other uses. Greenhouse research was conducted to evaluate the effect of SX-1552 and SX-1552A (an acid metabolite) on seven aquatic plants: alligatorweed [Alternanthera philoxeroides (Mart.) Grisebd, Carolina waterhyssop [Bacopa monnieri (L.) Pennell], fanwort (Cabomba caroliniana Gray), monoecious hydrilla [Hydrilla verticillata (L. f.) Royle], parrotfeather [Myriophyllum aquaticum (Vell.) Verdcd, variable watermilfoil (Myriophyllum heterophyllum Michx.), and American waterwillow [Justicia americana (L.) Vahl]. SX-1552 and SX-1552A were applied to these species as an in-water, 4-wk static exposure at rates of 0 to 81 mu g L-1. Fanwort was not controlled by SX-1552 at the rates evaluated, in contrast to the other species tested. Dry weight 50% effective concentration (EC50) values were <1 mu g L-1 SX-1552 for alligatorWeed, monoecious hydrilla, parrotfeather, and variable watermilfoil. Carolina waterhyssop and American waterwillow SX-1552 EC50 values were 5.0 and 5.1 mu g L-1, respectively. These six species were less sensitive to SX-1552A with dry weight EC50 values of 1.6 to 77.1 mu g L-1. Plant control ratings also indicated that response of the six sensitive species increased from 2 to 4 wk after treatment. Further research is needed on additional species as well as concentration exposure-time determination for the species evaluated here. C1 [Richardson, Robert J.; Haug, Erika J.] N Carolina State Univ, Dept Crop Sci, Raleigh, NC 27695 USA. [Netherland, Michael D.] US Army Engineer Res & Dev Ctr, Gainesville, FL 32653 USA. RP Richardson, RJ (reprint author), N Carolina State Univ, Dept Crop Sci, Box 7620, Raleigh, NC 27695 USA. EM rob_richardson@ncsu.edu NR 33 TC 0 Z9 0 U1 3 U2 9 PU AQUATIC PLANT MANAGEMENT SOC, INC PI VICKSBURG PA PO BOX 821265, VICKSBURG, MS 39182 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JAN PY 2016 VL 54 BP 26 EP 31 PG 6 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA DA7DP UT WOS:000367965100004 ER PT J AU Mudge, CR Perret, AJ Winslow, JR AF Mudge, Christopher R. Perret, Alexander J. Winslow, Jonathan R. TI Evaluation of foliar herbicide and surfactant combinations for control of giant salvinia at three application timings SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article DE adjuvant; carfentrazone-ethyl; chemical control; diquat; endothall; flumioxazin; glyphosate; Salvinia molesta; surfactant; tank mix ID WATER TEMPERATURE; SUBMERSED PLANTS; GLYPHOSATE; MOLESTA; EFFICACY; DIQUAT; RESISTANCE; ENDOTHALL AB The invasive aquatic fern, giant salvinia (Salvinia molesta Mitchell). continues to spread throughout Louisiana, Texas, and the Gulf Coast Region. Most infestations in Louisiana are chemically managed throughout the growing season with a combination of the aquatic herbicides glyphosate and diquat plus two adjuvants (nonionic surfactant with buffering agents and a nonionic organosilicone surfactant). Heavy reliance on one spray mixture is of concern to natural resource managers because of the possibility of developing herbicide resistance. In addition, it is unknown whether combinations of other herbicides and adjuvants or surfactants can provide improved efficacy at certain times of the year (i.e., seasonal differences) compared with the primary treatment used operationally. Therefore, three mesocosm trials were conducted in the spring, summer, and fall to evaluate the efficacy of various combinations of glyphosate, carfentrazone-ethyl (hereafter, called carfentrazone), diquat, endothall, flumioxazin, and adjuvants on giant salvinia. All treatments involving glyphosate carfentrazone or flumioxazin, as well as endothall flumioxazin, resulted in giant salvinia injury 1 d after treatment. Glyphosate alone required 4 d to produce injury symptoms. All treatments, regardless of application time, were efficacious against giant salvinia 7 wk after treatment and reduced plant dry weight by 65 to 99% compared with the nontreated control. In general, fall herbicide treatments were less efficacious than the spring or summer treatments, and a great amount of regrowth also occurred following this application. The substitution of carfentrazone or flumioxazin for diquat into the glyphosate spray mixture, as well as other surfactants or adjuvants, provided similar control to the herbicide mixture used operationally in Louisiana. Based on these data, the new mixtures evaluated in the spring and summer can be viable alternatives to manage salvinia during the growing season. Further research is needed to evaluate other mixes for the fall when plant growth is decreasing. C1 [Mudge, Christopher R.] Louisiana State Univ, US Army Engineer Res & Dev Ctr, Sch Plant Environm & Soil Sci, Baton Rouge, LA 70803 USA. [Perret, Alexander J.; Winslow, Jonathan R.] Louisiana Dept Wildlife & Fisheries, Baton Rouge, LA 70898 USA. RP Mudge, CR (reprint author), Louisiana State Univ, US Army Engineer Res & Dev Ctr, Sch Plant Environm & Soil Sci, Baton Rouge, LA 70803 USA. EM Christopher.R.Mudge@usace.army.mil FU U.S. Army Engineer Research and Development Center Aquatic Plant Control Research Program; Louisiana Department of Wildlife and Fisheries FX This research was supported by the U.S. Army Engineer Research and Development Center Aquatic Plant Control Research Program and the Louisiana Department of Wildlife and Fisheries. The authors thank Dr. Michael Netherland and Lee Ann Glomski for providing reviews of this manuscript. Permission was granted by the Chief of Engineers to publish this information. Citation of trade names does not constitute endorsement or approval of the use of such commercial products. NR 34 TC 0 Z9 0 U1 7 U2 21 PU AQUATIC PLANT MANAGEMENT SOC, INC PI VICKSBURG PA PO BOX 821265, VICKSBURG, MS 39182 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JAN PY 2016 VL 54 BP 32 EP 36 PG 5 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA DA7DP UT WOS:000367965100005 ER PT J AU Glomski, L Netherland, MD AF Glomski, Leeann Netherland, Michael D. TI Impact of herbicide retention time on the efficacy of foliar treatments for control of crested floating heart SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article ID GLYPHOSATE; RAINFALL; RAINFASTNESS; JOHNSONGRASS C1 [Glomski, Leeann] US Army Corps Engineers, St Paul, MN 55155 USA. [Netherland, Michael D.] US Army Engineer Res & Dev Ctr, Ctr Aquat & Invas Plants, Gainesville, FL 32653 USA. RP Netherland, MD (reprint author), US Army Engineer Res & Dev Ctr, Ctr Aquat & Invas Plants, Gainesville, FL 32653 USA. EM mdnether@ufl.edu FU U.S. Army Engineer Research and Development Center Aquatic Plant Control Program FX This research was supported by the U.S. Army Engineer Research and Development Center Aquatic Plant Control Program. The authors thank Jonathan Ward and Josh Wood for their technical assistance. Permission was granted by the Chief of Engineers to publish this information. Citation of trade names does not constitute endorsement or approval of the use of such commercial products. NR 15 TC 0 Z9 0 U1 1 U2 3 PU AQUATIC PLANT MANAGEMENT SOC, INC PI VICKSBURG PA PO BOX 821265, VICKSBURG, MS 39182 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JAN PY 2016 VL 54 BP 50 EP 52 PG 3 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA DA7DP UT WOS:000367965100008 ER PT J AU Stutelberg, MW Dzisam, JK Monteil, AR Petrikovics, I Boss, GR Patterson, SE Rockwood, GA Logue, BA AF Stutelberg, Michael W. Dzisam, Joseph K. Monteil, Alexandre R. Petrikovics, Ilona Boss, Gerry R. Patterson, Steven E. Rockwood, Gary A. Logue, Brian A. TI Simultaneous determination of 3-mercaptopyruvate and cobinamide in plasma by liquid chromatography-tandem mass spectrometry SO JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES LA English DT Article DE Cyanide antidote; Sulfanegen; Mass spectrometry ID CORE WAVE-GUIDE; CYANIDE ANTIDOTE; SULFANEGEN SODIUM; NITRIC-OXIDE; HYDROXOCOBALAMIN; DETOXIFICATION; VITAMIN-B12; COBALAMIN; SULFURTRANSFERASES; IDENTIFICATION AB The current suite of Food and Drug Administration (FDA) approved antidotes (i.e., sodium nitrite, sodium thiosulfate, and hydroxocobalamin) are effective for treating cyanide poisoning, but individually, each antidote has major limitations (e.g., large effective dosage or delayed onset of action). To mitigate these limitations, next-generation cyanide antidotes are being investigated, including 3-mercaptopyruvate (3-MP) and cobinamide (Cbi). Analytical methods capable of detecting these therapeutics individually and simultaneously (for combination therapy) are essential for the development of 3-MP and Cbi as potential cyanide antidotes. Therefore, a liquid chromatography tandem mass-spectrometry method for the simultaneous analysis of 3-MP and Cbi was developed. Sample preparation of 3-MP consisted of spiking plasma with an internal standard (C-13(3)-3-MP), precipitation of plasma proteins, and derivatizing 3-MP with monobromobimane to produce 3-mercaptopyruvate-bimane. Preparation of Cbi involved denaturing plasma proteins with simultaneous addition of excess cyanide to convert each Cbi species to dicyanocobinamide (Cbi(CN)(2)). The limits of detection for 3-MP and Cbi were 0.5 mu M and 0.2 mu M, respectively. The linear ranges were 2-500 mu M for 3-MP and 0.5-50 mu M for Cbi. The accuracy and precision for 3-MP were 100 +/- 9% and <8.3% relative standard deviation (RSD), respectively. For Cbi(CN)(2), the accuracy was 100 +/- 13% and the precision was <9.5% RSD. The method presented here was used to determine 3-MP and Cbi from treated animals and may ultimately facilitate FDA approval of these antidotes for treatment of cyanide poisoning. (C) 2015 Elsevier By. All rights reserved. C1 [Stutelberg, Michael W.; Dzisam, Joseph K.; Logue, Brian A.] S Dakota State Univ, Dept Chem & Biochem, Avera Hlth & Sci Ctr 131, Brookings, SD 57007 USA. [Monteil, Alexandre R.; Patterson, Steven E.] Univ Minnesota, Ctr Drug Design, Minneapolis, MN 55455 USA. [Petrikovics, Ilona] Sam Houston State Univ, Dept Chem, Huntsville, TX 77341 USA. [Boss, Gerry R.] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA. [Rockwood, Gary A.] US Army Med Res Inst Chem Def, Analyt Toxicol Div, Aberdeen Proving Ground, MD 21010 USA. RP Logue, BA (reprint author), S Dakota State Univ, Dept Chem & Biochem, Avera Hlth & Sci Ctr 131, Box 2202, Brookings, SD 57007 USA. EM brian.logue@sdstate.edu OI Logue, Brian/0000-0002-2400-9339 FU Counter-ACT Program; National Institutes of Health Office of the Director (NIH OD); National Institute of Allergy and Infectious Diseases [Y1-OD-0690-01/A-120-B.P2010-01, Y1 -OD-1561-01/A120-B.P2011-01, AOD14020-001-00000/A120-B.P2014-01, AOD13016-001-00000/A120-B.P2013-01, AOD12060-001-00000/A120-B.P2012-01]; U.S. Dept. of Education GAANN award [P200A100103]; National Science Foundation Major Research Instrumentation Program [CHE-0922816, EPSCoR Grant 0091948]; National Science Foundation/EPSCoR [0091948] FX We gratefully acknowledge the support from the Counter-ACT Program, National Institutes of Health Office of the Director (NIH OD), and the National Institute of Allergy and Infectious Diseases, (Grant Number Y1-OD-0690-01/A-120-B.P2010-01, Y1 -OD-1561-01/A120-B.P2011-01, AOD14020-001-00000/A120-B.P2014-01, AOD13016-001-00000/A120-B.P2013-01, AOD12060-001-00000/A120-B.P2012-01). We also would like to acknowledge support by U.S. Dept. of Education GAANN award (P200A100103). We thank the National Science Foundation Major Research Instrumentation Program (Grant Number CHE-0922816) for funding the AB SCIEX QTRAP 5500 LC/MS/MS (EPSCoR Grant 0091948). Lastly, we would like to thank the South Dakota State University Campus Mass Spectrometry Facility for the use of the LC-MS-MS, obtained with the support from the National Science Foundation/EPSCoR (Grant Number 0091948). The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the national Science Foundation, the National Institute of Health, or Department of Defense. NR 39 TC 1 Z9 1 U1 4 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1570-0232 EI 1873-376X J9 J CHROMATOGR B JI J. Chromatogr. B PD JAN 1 PY 2016 VL 1008 BP 181 EP 188 DI 10.1016/j.jchromb.2015.11.027 PG 8 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA DB0NT UT WOS:000368205500024 PM 26655110 ER PT J AU Nadal-Caraballo, NC Melby, JA Gonzalez, VM AF Nadal-Caraballo, Norberto C. Melby, Jeffrey A. Gonzalez, Victor M. TI Statistical Analysis of Historical Extreme Water Levels for the US North Atlantic Coast Using Monte Carlo Life-Cycle Simulation SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE Statistical analysis; extreme value analysis; historical water levels; Monte Carlo life-cycle simulation; generalized Pareto distribution; peaks-over-threshold; partial duration series ID UNCERTAINTIES; EVENTS; SERIES AB A statistical analysis of extreme water levels was performed for 23 locations throughout the U.S. North Atlantic coast. Extreme value analysis, which focused on historical observations, was followed by the application of a Monte Carlo life-cycle simulation methodology. This study was part of a broader effort to quantify coastal flooding hazards in this region. Twenty-three stations were selected based on location and record length, meeting the requirement of a minimum of 30 years of hourly water-level measurements. Monthly maxima data were also used to complement the hourly water-level observations. The use of available water-level data was maximized through the development of partial duration series that combined both monthly maxima and hourly data. A generalized Pareto distribution was used to fit combined partial duration series corresponding to each of the 23 locations. The Monte Carlo life-cycle methodology was used to simulate 10,000 cycles of 100 years each, effectively extending the record lengths of extreme events through statistical simulation. A bootstrapping technique was used as part of Monte Carlo life-cycle simulation in order to, develop probability distributions of extreme water levels, including mean, as well as 10% and 90% nonexceedance confidence limits (equivalent to an 80% confidence interval). Water-level probabilities determined in this study were compared to results from a previous effort where the generalized extreme value distribution was used to fit monthly maxima data. C1 [Nadal-Caraballo, Norberto C.; Melby, Jeffrey A.; Gonzalez, Victor M.] US Army, Engn Res & Dev Ctr, Coastal Hydraul Lab, Vicksburg, MS 39180 USA. RP Nadal-Caraballo, NC (reprint author), US Army, Engn Res & Dev Ctr, Coastal Hydraul Lab, Vicksburg, MS 39180 USA. EM norberto.c.nadal-caraballo@usace.army.mil FU U.S. Army Corps of Engineers as part of North Atlantic Coast Comprehensive Study (NACCS) FX This study was sponsored by the U.S. Army Corps of Engineers as part of the North Atlantic Coast Comprehensive Study (NACCS). The research described herein was conducted at the U.S. Army Engineer Research and Development Center, Coastal and Hydraulics Laboratory. The data and assistance provided by Chris Zervas and Michael Michalski of NOAA-NOS CO-OPS were greatly appreciated. The authors also appreciate the constructive comments of the anonymous reviews. NR 28 TC 1 Z9 1 U1 2 U2 12 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI COCONUT CREEK PA 5130 NW 54TH STREET, COCONUT CREEK, FL 33073 USA SN 0749-0208 EI 1551-5036 J9 J COASTAL RES JI J. Coast. Res. PD JAN PY 2016 VL 32 IS 1 BP 35 EP 45 DI 10.2112/JCOASTRES-D-15-00031.1 PG 11 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA DB0UA UT WOS:000368221800002 ER PT J AU Cheng, J Wang, P Smith, ER AF Cheng, Jun Wang, Ping Smith, Ernest R. TI Hydrodynamic Conditions Associated with an Onshore Migrating and Stable Sandbar SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE Sandbar migration; equilibrium beach profile; undertow; velocity skewness and asymmetry; physical model ID WEST-CENTRAL FLORIDA; INDUCED SEDIMENT TRANSPORT; DOPPLER-VELOCIMETER DATA; SURF-ZONE; SHEET FLOW; BEACH; NEARSHORE; BREAKING; MODEL; WAVES AB In this study, large-scale three-dimensional laboratory data were analyzed to identify the hydrodynamic conditions associated with the onshore migration of a sandbar and the subsequent equilibrium state of a stable bar. The initial sandbar was constructed offshore and out of equilibrium, with a symmetrical shape. The bar became asymmetrical as it migrated onshore. As the rate of onshore migration slowed, the bar was restored to a symmetrical shape toward an equilibrium state. Wave and near-bottom velocity across the surf zone were measured during the onshore sandbar migration. The near-bottom velocity skewness analyzed wave by wave indicates that before the sandbar reached equilibrium, the velocity was skewed offshore in the nearshore region and was skewed onshore seaward of the bar. However, the velocity skewness pattern reversed when the beach profile reached equilibrium and the sandbar became stable. The location of maximum undertow velocity moved from nearshore to the bar crest as the sandbar evolved toward equilibrium. Furthermore, the peak onshore-directed acceleration was greater than the peak offshore-directed acceleration throughout the surf zone during the periods of both onshore migrating and stable sandbar. The maximum difference between the onshore- and the offshore-directed acceleration occurred at the seaward side of the bar crest. The analyses of the hydrodynamic conditions associated with sandbar movement in a controlled laboratory experiment provide insights on the mechanisms of sandbar migration. C1 [Cheng, Jun; Wang, Ping] Univ S Florida, Sch Geosci, Tampa, FL 33620 USA. [Smith, Ernest R.] US Army Engn Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. RP Cheng, J (reprint author), Univ S Florida, Sch Geosci, Tampa, FL 33620 USA. EM jun@mail.usf.edu FU graduate school of University of South Florida; U.S. Army Engineer Research and Development Center FX This study is jointly funded by the U.S. Army Engineer Research and Development Center and the graduate school of the University of South Florida. Permission to publish this paper was granted by the Headquarters, U.S. Army Corps of Engineers. NR 44 TC 0 Z9 0 U1 1 U2 4 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI COCONUT CREEK PA 5130 NW 54TH STREET, COCONUT CREEK, FL 33073 USA SN 0749-0208 EI 1551-5036 J9 J COASTAL RES JI J. Coast. Res. PD JAN PY 2016 VL 32 IS 1 BP 153 EP 163 DI 10.2112/JCOASTRES-D-14-00174.1 PG 11 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA DB0UA UT WOS:000368221800012 ER PT J AU Morang, A AF Morang, Andrew TI Hurricane Barriers in New England and New Jersey: History and Status after Five Decades SO JOURNAL OF COASTAL RESEARCH LA English DT Review DE Hurricane surge; Fox Point; New Bedford; Pawcatuck; Stamford; New London; Raritan Bay; Charles River Dam; Boston; Providence; Great New England Hurricane; Hurricane Carol; Hurricane Sandy AB Massachusetts, Rhode Island, Connecticut, and New Jersey suffered damage, flooding, and deaths from three major hurricanes in less than two decades during the mid-twentieth century. One of these, the Great New England Hurricane of 21 September 1938, caused unprecedented damage and flooded Providence, New London, and other urban areas. Following Hurricane Carol in 1954, the 84th Congress (1st Session, Public Law 71, 15 June 1955) authorized and directed the Secretary of the Army to conduct surveys and studies of damages, causes, and remediation measures with regard to hurricanes. After extensive studies during the late 1950s, Congress authorized and funded seven hurricane protection projects: (1) in Fox Point, Providence, Rhode Island, a barrier, navigation gates, and pumps; (2) in New Bedford, Massachusetts, a barrier, navigation gates, and pumps; (3) in New London, Connecticut, a barrier and navigation gate; (4) in Pawcatuck, Connecticut, earthfill and concrete walls; (5) in Stamford, Connecticut, a barrier and pump station; (6) in Raritan and Sandy Hook Bays, New Jersey, levees, beach fill, and pumps; and (7) in Charles River, Boston, Massachusetts, a dam with locks and pumps. Most of the projects have not been tested with storm-water elevations near their design elevation. Exceptions are the Charles River dam, which helped prevent flooding during the Blizzard of 1978, and Raritan Bay, during Hurricane Sandy. For lower levels, all projects have performed as designed. After the flooding caused by Hurricane Sandy in 2012, comprehensive hurricane barriers have been proposed for the New York area. Many major challenges would confront planners and designers of new hurricane barriers in the New York Bight area compared to the earlier projects: (1) Far more extensive environmental impact studies would have to be conducted now; (2) obtaining permits and negotiating property rights would be a challenging multiyear process; and (3) obtaining easements and construction access would be vastly more difficult now because of the substantially higher value of coastal real estate. C1 [Morang, Andrew] HN CE Engn Res & Dev Ctr, Coastal & Hydraul Lab, Coastal Engn Branch, Vicksburg, MS 39180 USA. RP Morang, A (reprint author), HN CE Engn Res & Dev Ctr, Coastal & Hydraul Lab, Coastal Engn Branch, Vicksburg, MS 39180 USA. EM Andrew.Morang@usace.army.mil NR 84 TC 0 Z9 0 U1 4 U2 8 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0749-0208 EI 1551-5036 J9 J COASTAL RES JI J. Coast. Res. PD JAN PY 2016 VL 32 IS 1 BP 181 EP 205 DI 10.2112/JCOASTRES-D-14-00074.1 PG 25 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA DB0UA UT WOS:000368221800015 ER PT J AU Wilber, DH Clarke, DG Alcoba, CM Gallo, J AF Wilber, Dara H. Clarke, Douglas G. Alcoba, Catherine M. Gallo, Jenine TI Windowpane flounder (Scophthalmus aquosus) and winter flounder (Pseudopleuronectes americanus) responses to cold temperature extremes in a Northwest Atlantic estuary SO JOURNAL OF SEA RESEARCH LA English DT Article; Proceedings Paper CT 9th International Flatfish Symposium (IFS) CY NOV, 2014 CL Cle Elum, WA DE New York/New Jersey Harbor; Flatfish; Overwintering; Thermal stress ID OF-THE-YEAR; PLAICE PLEURONECTES-PLATESSA; MOVEMENT PATTERNS; HABITAT QUALITY; SEA PLAICE; RECRUITMENT; GROWTH; LARVAL; MORTALITY; POPULATION AB The effect of climate variability on flatfish includes not only the effects of warming on sensitive life history stages, but also impacts from more frequent or unseasonal extreme cold temperatures. Cold weather events can affect the overwintering capabilities of flatfish near their low temperature range limits. We examined the responses of two flatfish species, the thin-bodied windowpane (Scophthalmus aquosus) and cold-tolerant winter flounder (Pseudopleuronectes americanus), to variable winter temperatures in a Northwest Atlantic estuary using abundance and size data collected during a monitoring study, the Aquatic Biological Survey, conducted from 2002 to 2010. Winter and spring abundances of small (50 to 120 mm total length) juvenile windowpane were positively correlated with adult densities (spawning stock) and fall temperatures (thermal conditions experienced during post-settlement development for the fall-spawned cohort) of the previous year. Windowpane abundances in the estuary were significantly reduced and the smallest size class was nearly absent after several consecutive years with cold (minimum temperatures <1 degrees C) winters. Interannual variation in winter flounder abundances was unrelated to the severity of winter temperatures. A Paulik diagram illustrates strong positive correlations between annual abundances of sequential winter flounder life history stages (egg, larval, Age-1 juvenile, and adult male) within the estuary, reflecting residency within the estuary through their first year of life. Temperature variables representing conditions during winter flounder larval and post-settlement development were not significant factors in multiple regression models exploring factors that affect juvenile abundances. Likewise, densities of predators known to consume winter flounder eggs and/or post-settlement juveniles were not significantly related to interannual variation in winter flounder juvenile abundances. Colder estuarine temperatures through the first year of life were associated with smaller Age-1 winter flounder body size. For example, Age-1 winter flounder developing under conditions that differed by 1.9 degrees C in mean daily water temperature, averaged 98.7 mm total length (TL) and 123.1 mm TL, for the relatively cold vs. moderate years, respectively. More frequent cold temperature extremes associated with climate variability may negatively impact the overwintering capabilities of some flatfish near their cold temperature range limits, whereas cold-tolerant species may experience reduced growth, which imparts the ecological challenges associated with smaller body size. (C) 2015 Elsevier B.V. All rights reserved. C1 [Wilber, Dara H.] HX5, Charleston, SC 29412 USA. [Clarke, Douglas G.] HDR Engn Inc, Mahwah, NJ 07495 USA. [Alcoba, Catherine M.; Gallo, Jenine] US Army, Corps Engineers New York Dist, New York, NY 10278 USA. RP Wilber, DH (reprint author), HX5, 664 Old Plantat Rd, Charleston, SC 29412 USA. EM darawilber@gmail.com NR 49 TC 0 Z9 0 U1 3 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1385-1101 EI 1873-1414 J9 J SEA RES JI J. Sea Res. PD JAN PY 2016 VL 107 SI SI BP 23 EP 30 DI 10.1016/j.seares.2015.04.005 PN 1 PG 8 WC Marine & Freshwater Biology; Oceanography SC Marine & Freshwater Biology; Oceanography GA DA8GP UT WOS:000368043400005 ER PT J AU Martin, RC Grier, T Canham-Chervak, M Anderson, MK Bushman, TT DeGroot, DW Jones, BH AF Martin, Robyn C. Grier, Tyson Canham-Chervak, Michelle Anderson, Morgan K. Bushman, Timothy T. DeGroot, David W. Jones, Bruce H. TI VALIDITY OF SELF-REPORTED PHYSICAL FITNESS AND BODY MASS INDEX IN A MILITARY POPULATION SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH LA English DT Article DE army; self-report; APFT; exercise; survey; recall ID ACTIVITY QUESTIONNAIRE; RISK-FACTORS; INJURIES; ARMY; WEIGHT; HEIGHT; REPRODUCIBILITY; RELIABILITY; HEALTH; UNIT AB Martin, RC, Grier, T, Canham-Chervak, M, Anderson, MK, Bushman, TT, DeGroot, DW, and Jones, BH. Validity of self-reported physical fitness and body mass index in a military population. J Strength Cond Res 30(1): 26-32, 2016Many epidemiological studies rely on valid physical fitness data. The purpose of this investigation was to assess the validity of self-reported Army Physical Fitness Test (APFT) data and determine whether men and women recall APFT performance differently. U.S. Army soldiers (N = 1,047) completed a survey, including questions on height, weight, and most recent APFT performance. Height, weight, and APFT performance were also obtained from unit records. The mean +/- SDs for unit and self-reported push-up repetitions were 63.5 +/- 13.1 and 66.3 +/- 14.0 for men and 37.7 +/- 12.8 and 40.2 +/- 12.8 for women, respectively. The mean +/- SD for unit- and self-reported sit-up repetitions were 66.3 +/- 11.4 and 68.1 +/- 12.1 for men and 64.2 +/- 13.6 and 66.5 +/- 12.9 for women, respectively. The mean +/- SD unit- and self-reported 2-mile run times were 15.2 +/- 1.8 and 14.9 +/- 1.6 minutes for men, and 18.0 +/- 2.9 and 17.4 +/- 1.9 minutes for women, respectively. Unit- and self-reported body mass indices (BMIs) (calculated by height and weight) were 26.4 +/- 3.4 and 26.3 +/- 3.6 for men and 24.6 +/- 2.8 and 24.2 +/- 3.3 for women. Correlations between unit- and self-reported scores for push-ups, sit-ups, 2-mile run, height, weight, and BMI were 0.82, 0.78, 0.85, 0.87, 0.97, and 0.88 for men and 0.86, 0.84, 0.87, 0.78, 0.98, and 0.78 for women, respectively. On average, men and women slightly overreported performance on the APFT and overestimated height, resulting in underestimated BMI. There was no difference in recall ability between men and women (p > 0.05). The very good to excellent correlations (r = 0.78-0.98) between unit- and self-reported scores indicate that self-reported data are valid for capturing physical fitness performance in this population. C1 [Martin, Robyn C.; Grier, Tyson; Canham-Chervak, Michelle; Anderson, Morgan K.; Bushman, Timothy T.; DeGroot, David W.; Jones, Bruce H.] US Army, Publ Hlth Command, Army Inst Publ Hlth, Injury Prevent Program, Aberdeen Proving Ground, MD 21005 USA. RP Grier, T (reprint author), US Army, Publ Hlth Command, Army Inst Publ Hlth, Injury Prevent Program, Aberdeen Proving Ground, MD 21005 USA. EM tyson.l.grier.civ@mail.mil NR 25 TC 2 Z9 2 U1 5 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1064-8011 EI 1533-4287 J9 J STRENGTH COND RES JI J. Strength Cond. Res. PD JAN PY 2016 VL 30 IS 1 BP 26 EP 32 DI 10.1519/JSC.0000000000001026 PG 7 WC Sport Sciences SC Sport Sciences GA DA4TC UT WOS:000367792600004 PM 26683633 ER PT J AU Tolisano, AM Justin, GA Ruhl, DS Cable, BB AF Tolisano, Anthony M. Justin, Grant A. Ruhl, Douglas S. Cable, Benjamin B. TI Rhinology and Medical Malpractice: An Update of the Medicolegal Landscape of the Last Ten Years SO LARYNGOSCOPE LA English DT Article DE Rhinology; malpractice; negligence ID ENDOSCOPIC SINUS SURGERY; LEGAL RESPONSIBILITY; SINONASAL DISEASE; LIABILITY; LITIGATION; OTOLARYNGOLOGY; NERVE; TRIALS; CANCER; INJURY AB Objectives/Hypothesis: Malpractice claims pertaining to rhinological procedures are a potentially important source of information that could be used to minimize the risk of future litigation and improve patient care. Study Design: A retrospective review of a publicly available database containing jury verdicts and settlements. Methods: The LexisNexis Jury Verdicts and Settlements database was reviewed for all lawsuits and out-of-court adjudications related to the practice of rhinology. Data including patient demographics, type of surgery performed, plaintiff allegation, nature of injury, outcomes, and indemnities were collected and analyzed. Results: Of 85 cases meeting inclusion criteria, 42 were decided by a jury and 43 were adjudicated out of court. Endoscopic sinus surgery was the most commonly litigated surgery. The plaintiff was favored when the eye was injured (P=0.0196), but the defendant was favored when neuropsychological injuries (P=0.0137) or recurrent/worsened symptoms (P=0.0050) were cited. No difference was found when death or skull base injuries occurred. When lack of informed consent was an allegation, the defendant was favored (P=0.0001). A payout was made in two-thirds of cases overall, but the defendant was favored in two-thirds of cases decided by a jury. Payments were significant for both out-of-court settlements ($ 1.3 million) and jury verdicts ($ 2 million). Conclusions: Endoscopic sinus surgery remains the most commonly litigated rhinology procedure and has the potential to result in large payouts. Meticulous dissection, recognition of complications, and documentation of informed consent remain paramount for providing optimal patient care. C1 [Tolisano, Anthony M.; Ruhl, Douglas S.; Cable, Benjamin B.] Tripler Army Med Ctr, Dept Otolaryngol, Honolulu, HI 96859 USA. [Justin, Grant A.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. RP Tolisano, AM (reprint author), Tripler Army Med Ctr, Dept Otolaryngol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM anthony.m.tolisano.mil@mail.mil NR 27 TC 2 Z9 2 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0023-852X EI 1531-4995 J9 LARYNGOSCOPE JI Laryngoscope PD JAN PY 2016 VL 126 IS 1 BP 14 EP 19 DI 10.1002/lary.25533 PG 6 WC Medicine, Research & Experimental; Otorhinolaryngology SC Research & Experimental Medicine; Otorhinolaryngology GA DA9LT UT WOS:000368131000013 PM 26256664 ER PT J AU Tran, DT AF Tran, Dat T. TI Synthesis of porous ZnO based materials using an agarose gel template for H2S desulfurization SO RSC ADVANCES LA English DT Article ID HYDROGEN-SULFIDE ADSORPTION; TEMPERATURE DESULFURIZATION; MID-TEMPERATURE; GRAPHITE OXIDE; REMOVAL; BIOGAS; SIZE; CHEMISORPTION; PERFORMANCE; MORPHOLOGY AB This work describes the synthesis and characterization of pure ZnO and Ni-doped ZnO materials using agarose gel as a template for H2S desulfurization. H2S gas is not only harmful to the environment, but also corrosive to metals and poisonous to fuel reformer and fuel cell catalysts. Removal of H2S is an important step in fuel processing technology. This synthetic approach resulted in highly porous network ZnO based sorbent materials. The phase structure and morphology of these two materials were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Brunauer, Emmett and Teller (BET) surface area measurements, and mercury porosimetry. The H2S desulfurization performance of the as-synthesized ZnO and Ni-doped ZnO materials versus commercial ZnO was studied in a simulated fuel processing operation at 400 degrees C with an initial H2S concentration of 400 ppmv. It is shown that the sulfur adsorption capacity is greatly affected by the size and morphology of the particles. Desulfurization analysis revealed that commercial ZnO exhibits a low saturation capacity of 245 mg S per g while as-synthesized ZnO has a capacity of 457 mg S per g. Notably, when ZnO was doped with 4 wt% Ni, the sorbent capacity increased still further to 730 mg S per g. C1 [Tran, Dat T.] US Army, Res Lab, RDRL SED E, Adelphi, MD 20783 USA. RP Tran, DT (reprint author), US Army, Res Lab, RDRL SED E, Adelphi, MD 20783 USA. EM dat.t.tran4.civ@mail.mil NR 38 TC 2 Z9 2 U1 5 U2 33 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2046-2069 J9 RSC ADV JI RSC Adv. PY 2016 VL 6 IS 2 BP 1339 EP 1345 DI 10.1039/c5ra21383e PG 7 WC Chemistry, Multidisciplinary SC Chemistry GA DA6ZA UT WOS:000367953200059 ER PT J AU Hanrahan, B Sanchez, L Waits, CM Polcawich, RG AF Hanrahan, B. Sanchez, L. Waits, C. M. Polcawich, R. G. TI Improved pyroelectric performance for thin film lead zirconate titanate (PZT) capacitors with IrO2 electrodes SO SMART MATERIALS AND STRUCTURES LA English DT Article DE pyroelectric; energy harvesting; thin films ID LEAKAGE CURRENT; CONDUCTIVITY; CONVERSION; CERAMICS AB A four orders-of-magnitude reduction in high temperature leakage current was realized through the use of IrO2 top electrodes in thin film lead zirconate titanate capacitors which has been shown to directly impact the performance of future energy conversion applications. Pyroelectric energy conversion is enhanced near the material Curie temperature, but elevated leakage current in this temperature range hinders current applications. Conductivity experiments varying temperature, composition, and applied bias showed that oxygen vacancy hopping dominates the leakage current in the thin film capacitors above 200 degrees C. IrO2 top electrodes allow for a reduction in vacancy concentration by allowing for oxygen to be reintroduced during a post-processing annealing step for the thin film. The power lost to leakage current through the pyroelectric conversion cycle is explored. Improvements in remnant polarization and pyroelectric constant are also realized. C1 [Hanrahan, B.] Oak Ridge Associated Univ, US Army, Res Lab, Adelphi, MD 20783 USA. [Sanchez, L.] VerAvanti Inc, Redmond, WA 98052 USA. [Waits, C. M.; Polcawich, R. G.] US Army, Res Lab, Adelphi, MD 20783 USA. RP Hanrahan, B (reprint author), Oak Ridge Associated Univ, US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM brendan.m.hanrahan.civ@mail.mil NR 39 TC 0 Z9 0 U1 4 U2 7 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0964-1726 EI 1361-665X J9 SMART MATER STRUCT JI Smart Mater. Struct. PD JAN PY 2016 VL 25 IS 1 AR 015025 DI 10.1088/0964-1726/25/1/015025 PG 9 WC Instruments & Instrumentation; Materials Science, Multidisciplinary SC Instruments & Instrumentation; Materials Science GA DB0UJ UT WOS:000368222700030 ER PT J AU Pelled, G Sheyn, D Tawackoli, W Jun, DS Koh, Y Su, S Yakubovich, DC Kallai, I Ben Antebi, B Da, XY Gazit, Z Bae, H Gazit, D AF Pelled, Gadi Sheyn, Dmitriy Tawackoli, Wafa Jun, Deuk Soo Koh, Youngdo Su, Susan Yakubovich, Doron Cohn Kallai, Ilan Antebi, Ben Da, Xiaoyu Gazit, Zulma Bae, Hyun Gazit, Dan TI BMP6-Engineered MSCs Induce Vertebral Bone Repair in a Pig Model: A Pilot Study SO STEM CELLS INTERNATIONAL LA English DT Article ID MESENCHYMAL STEM-CELLS; MEDIATED GENE-THERAPY; TISSUE REGENERATION; RANDOMIZED-TRIAL; CANCELLOUS BONE; FRACTURES; DEFECT; SCAFFOLDS; DELIVERY; VERTEBROPLASTY AB Osteoporotic patients, incapacitated due to vertebral compression fractures (VCF), suffer grave financial and clinical burden. Current clinical treatments focus on symptoms' management but do not combat the issue at the source. In this pilot study, allogeneic, porcine mesenchymal stem cells, overexpressing the BMP6 gene (MSC-BMP6), were suspended in fibrin gel and implanted into a vertebral defect to investigate their effect on bone regeneration in a clinically relevant, large animal pig model. To check the effect of the BMP6-modified cells on bone regeneration, a fibrin gel only construct was used for comparison. Bone healing was evaluated in vivo at 6 and 12 weeks and ex vivo at 6 months. In vivo CT showed bone regeneration within 6 weeks of implantation in the MSC-BMP6 group while only minor bone formation was seen in the defect site of the control group. After 6 months, ex vivo analysis demonstrated enhanced bone regeneration in the BMP6-MSC group, as compared to control. This preclinical study presents an innovative, potentially minimally invasive, technique that can be used to induce bone regeneration using allogeneic gene modified MSCs and therefore revolutionize current treatment of challenging conditions, such as osteoporosis-related VCFs. C1 [Pelled, Gadi; Sheyn, Dmitriy; Tawackoli, Wafa; Jun, Deuk Soo; Koh, Youngdo; Su, Susan; Gazit, Zulma; Bae, Hyun; Gazit, Dan] Cedars Sinai Med Ctr, Dept Surg, Los Angeles, CA 90048 USA. [Pelled, Gadi; Sheyn, Dmitriy; Tawackoli, Wafa; Su, Susan; Gazit, Zulma; Gazit, Dan] Cedars Sinai Med Ctr, Board Governors Regenerat Med Inst, Los Angeles, CA 90048 USA. [Pelled, Gadi; Tawackoli, Wafa; Da, Xiaoyu] Cedars Sinai Med Ctr, Biomed Imaging Res Inst, Los Angeles, CA 90048 USA. [Pelled, Gadi; Yakubovich, Doron Cohn; Kallai, Ilan; Antebi, Ben; Gazit, Zulma; Gazit, Dan] Hebrew Univ Jerusalem, Hadassah Fac Dent Med, Skeletal Biotech Lab, Jerusalem, Israel. [Jun, Deuk Soo] Gachon Univ Med & Sci, Gil Med Ctr, Dept Orthopaed Surg, Inchon, South Korea. [Koh, Youngdo] EwhaWomans Univ, Sch Med, Dept Orthoped, Seoul, South Korea. [Antebi, Ben] US Army Inst Surg Res, San Antonio, TX 78234 USA. RP Gazit, D (reprint author), Cedars Sinai Med Ctr, Dept Surg, Los Angeles, CA 90048 USA. EM dan.gazit@csmc.edu OI Bae, Hyun/0000-0002-6386-344X FU NIH/National Center for Advancing Translational Science (NCATS) UCLA CTSI [UL1TR000124]; USAMRMC/TATRC [W81XWH-09-1-0644]; CIRM [DR2-05288] FX The research described was partially supported by NIH/National Center for Advancing Translational Science (NCATS) UCLA CTSI, Grant no. UL1TR000124, USAMRMC/TATRC, Grant no. W81XWH-09-1-0644, and CIRM, Grant no. DR2-05288. NR 53 TC 0 Z9 0 U1 1 U2 9 PU HINDAWI PUBLISHING CORP PI NEW YORK PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA SN 1687-966X EI 1687-9678 J9 STEM CELLS INT JI Stem Cells Int. PY 2016 AR 6530624 DI 10.1155/2016/6530624 PG 8 WC Cell & Tissue Engineering SC Cell Biology GA DB1WK UT WOS:000368299500001 ER PT J AU Cap, AP AF Cap, Andrew P. TI Platelet storage: a license to chill! SO TRANSFUSION LA English DT Editorial Material ID FROZEN-BLOOD PRODUCTS; TRANSFUSION; TRAUMA; 4-DEGREES-C; MILITARY; 22-C; 4-C C1 [Cap, Andrew P.] US Army, Inst Surg Res, Blood Res Program, San Antonio, TX 78234 USA. RP Cap, AP (reprint author), US Army, Inst Surg Res, Blood Res Program, San Antonio, TX 78234 USA. EM andrew.p.cap.mil@mail.mil NR 24 TC 7 Z9 7 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 EI 1537-2995 J9 TRANSFUSION JI Transfusion PD JAN PY 2016 VL 56 IS 1 BP 13 EP 16 DI 10.1111/trf.13433 PG 4 WC Hematology SC Hematology GA DA6YJ UT WOS:000367951500001 PM 26756706 ER PT J AU Bhavsar, AK Gelner, EJ Shorma, T AF Bhavsar, Amit K. Gelner, Elizabeth J. Shorma, Toni TI Common Questions About the Evaluation of Acute Pelvic Pain SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID LOWER QUADRANT PAIN; ADNEXAL TORSION; ABDOMINAL-PAIN; INFLAMMATORY-DISEASE; COMPUTED-TOMOGRAPHY; ECTOPIC PREGNANCY; WOMEN; ULTRASOUND; DIAGNOSIS; AGE AB Acute pelvic pain is defined as lower abdominal or pelvic pain of less than three months' duration. It is a common presentation in primary care. Evaluation can be challenging because of a broad differential diagnosis and because many associated signs and symptoms are nonspecific. The most common diagnoses in reproductive-aged women with acute pelvic pain are idiopathic pelvic pain, pelvic inflammatory disease, acute appendicitis, ovarian cysts, ectopic pregnancy, and endometriosis. Among postmenopausal women, cancer must be considered. Findings from the history and physical examination can point to likely diagnoses, and laboratory testing and imaging can help confirm. Women of reproductive age should take a pregnancy test. In early pregnancy, transvaginal ultrasonography and beta human chorionic gonadotropin levels can help identify ectopic pregnancy and spontaneous abortion. For nonpregnant women, ultrasonography or computed tomography is indicated, depending on the possible diagnosis (e.g., ultrasonography is preferred when ovarian pathology is suspected). If ultrasonography results are nondiagnostic, magnetic resonance imaging can be helpful in pregnant women when acute appendicitis is suspected. If magnetic resonance imaging is unavailable, computed tomography may be indicated. Copyright (C) 2016 American Academy of Family Physicians. C1 [Bhavsar, Amit K.; Gelner, Elizabeth J.; Shorma, Toni] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Bhavsar, AK (reprint author), Tripler Army Med Ctr, 1 Jarret White Rd, Honolulu, HI 96859 USA. EM amit.k.bhavsar.mil@mail.mil NR 37 TC 0 Z9 0 U1 0 U2 6 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X EI 1532-0650 J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD JAN 1 PY 2016 VL 93 IS 1 BP 41 EP 48 PG 8 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA DA5SU UT WOS:000367863600006 PM 26760839 ER PT J AU Juliano, JJ Parobek, CM Brazeau, NF Ngasala, B Randrianarivelojosia, M Lou, C Mwandagalirwa, K Tshefu, A Dhar, R Das, BK Hoffman, I Martinson, F Martensson, A Saunders, DL Kumar, N Meshnick, SR AF Juliano, Jonathan J. Parobek, Christian M. Brazeau, Nicholas F. Ngasala, Billy Randrianarivelojosia, Milijaona Lou, Chanthap Mwandagalirwa, Kashamuka Tshefu, Antoinette Dhar, Ravi Das, Bidyut K. Hoffman, Irving Martinson, Francis Martensson, Andreas Saunders, David L. Kumar, Nirbhay Meshnick, Steven R. TI Pooled Amplicon Deep Sequencing of Candidate Plasmodium falciparum Transmission-Blocking Vaccine Antigens SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID MALARIA VACCINES; CONTROLLED-TRIAL; AFRICA; SAFETY; ADULTS AB Polymorphisms within Plasmodium falciparum vaccine candidate antigens have the potential to compromise vaccine efficacy. Understanding the allele frequencies of polymorphisms in critical binding regions of antigens can help in the designing of strain-transcendent vaccines. Here, we adopt a pooled deep-sequencing approach, originally designed to study P. falciparum drug resistance mutations, to study the diversity of two leading transmission-blocking vaccine candidates, Pfs25 and Pfs48/45. We sequenced 329 P. falciparum field isolates from six different geographic regions. Pfs25 showed little diversity, with only one known polymorphism identified in the region associated with binding of transmission-blocking antibodies among our isolates. However, we identified four new mutations among eight non-synonymous mutations within the presumed antibody-binding region of Pfs48145. Pooled deep sequencing provides a scalable and cost-effective approach for the targeted study of allele frequencies of P falciparum candidate vaccine antigens. C1 Univ N Carolina, Sch Med, Div Infect Dis, Chapel Hill, NC 27599 USA. Univ N Carolina, Sch Med, Curriculum Genet & Mol Biol, Chapel Hill, NC 27599 USA. Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27599 USA. Univ N Carolina, Sch Med, Med, Chapel Hill, NC 27599 USA. Univ N Carolina, Sch Med, Philosophy Program, Chapel Hill, NC 27599 USA. Muhimbili Univ Hlth & Allied Sci, Dept Parasitol, Sch Publ Hlth, Dar Es Salaam, Tanzania. [Randrianarivelojosia, Milijaona] Inst Pasteur Madagascar, Dept Malariol, Antananarivo, Madagascar. [Lou, Chanthap; Saunders, David L.] Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand. [Mwandagalirwa, Kashamuka; Tshefu, Antoinette] Univ Kinshasa, Sch Publ Hlth, Kinshasa, DEM REP CONGO. NII, Dept Biotechnol, New Delhi, India. [Das, Bidyut K.] Sriram Chandra Bhanj SCB Med Coll, Dept Med, Odisha, India. [Martinson, Francis] Univ North Carolina Project, Lilongwe, Malawi. Karolinska Inst, Malaria Res, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden. Uppsala Univ, Int Maternal & Child Hlth Unit, Uppsala, Sweden. [Kumar, Nirbhay] Tulane Univ, Sch Publ Hlth & Trop Med, Dept Trop Med, New Orleans, LA USA. RP Juliano, JJ (reprint author), Univ N Carolina, Dept Med, Div Infect Dis, CB 7030,130 Mason Farm Rd, Chapel Hill, NC 27599 USA. EM jjuliano@med.unc.edu; christian_parobek@med.unc.edu; nbrazeau1@gmail.com; bngasala70@yahoo.co.uk; milijaon@pasteur.mg; chanthapl.ca@afrims.org; mkashamuka@yahoo.com; antotshe@yahoo.com; rdhar_in@yahoo.com; bidyutdas@hotmail.com; irving_hoffman@med.unc.edu; francis_martinson@med.unc.edu; andreas.martensson@ki.se; david.saunders@afrims.org; nkumar@tulane.edu; meshnick@email.unc.edu FU National Institute for Allergy and Infectious Diseases (NIAID) [R01AI089819, R21AI101427, R21 AI103466, R01AI107949]; National Institute of General Medicine Sciences [T32GM008719, T32GM007092, F30AI109979]; IDSA Medical Scholars Program; U.S. Department of Defense Global Emerging Surveillance Program; Swedish Development Cooperation Agency (SIDA) [Bil-Tz 16/9875007059]; Swedish Medical Research Council [2013-6594]; Institut Pasteur de Madagascar FX This project was funded by the National Institute for Allergy and Infectious Diseases (NIAID) grant R01AI089819 (JJJ), R21AI101427 (NK), R21 AI103466 (NK), and R01AI107949 (SRM). Christian M. Parobek was supported by the National Institute of General Medicine Sciences T32GM008719, T32GM007092, and F30AI109979. Nicholas F. Brazeau was funded by a grant from the IDSA Medical Scholars Program. David L. Saunders and Chanthap Lon were supported by the U.S. Department of Defense Global Emerging Surveillance Program. Billy Ngasala and Andreas Martensson were supported by The Swedish Development Cooperation Agency (SIDA) (Bil-Tz 16/9875007059). Andreas Martensson was also supported by The Swedish Medical Research Council (2013-6594). Sample collection in Sainte Marie was financially supported by Institut Pasteur de Madagascar. NR 16 TC 3 Z9 3 U1 2 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JAN PY 2016 VL 94 IS 1 BP 143 EP 146 DI 10.4269/ajtmh.15-0571 PG 4 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA DA3NX UT WOS:000367705500025 PM 26503281 ER PT J AU Kuchuloria, T Imnadze, P Mamuchishvili, N Chokheli, M Tsertsvadze, T Endeladze, M Mshvidobadze, K Gatserelia, L Makhviladze, M Kanashvili, M Mikautadze, T Nanuashvili, A Kiknavelidze, K Kokaia, N Makharadze, M Clark, DV Bautista, CT Farrell, M Fadeel, MA Maksoud, MA Pimentel, G House, B Hepburn, MJ Rivard, RG AF Kuchuloria, Tinatin Imnadze, Paata Mamuchishvili, Nana Chokheli, Maiko Tsertsvadze, Tengiz Endeladze, Marina Mshvidobadze, Ketevan Gatserelia, Lana Makhviladze, Manana Kanashvili, Marine Mikautadze, Teona Nanuashvili, Alexander Kiknavelidze, Khatuni Kokaia, Nora Makharadze, Manana Clark, Danielle V. Bautista, Christian T. Farrell, Margaret Fadeel, Moustafa Abdel Maksoud, Mohamed Abdel Pimentel, Guillermo House, Brent Hepburn, Matthew J. Rivard, Robert G. TI Hospital-Based Surveillance for Infectious Etiologies among Patients with Acute Febrile Illness in Georgia, 2008-2011 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID HUMAN BRUCELLOSIS; HEMORRHAGIC-FEVER; TYPHOID-FEVER; COUNTRY; EPIDEMIOLOGY; DIAGNOSIS; EGYPT AB Information on the infectious causes of undifferentiated acute febrile illness (AFT) in Georgia is essential for effective treatment and prevention. In May 2008, a hospital-based AFI surveillance was initiated at six hospitals in Georgia. Patients aged >= 4 years with fever >= 38 degrees C for >= 48 hours were eligible for surveillance. Blood culture and serologic testing were conducted for Leptospira spp., Brucella spp., West Nile virus (WNV), Crimean-Congo hemorrhagic fever virus, Coxiella burnetii, tick-borne encephalitis virus (TBEV), hantavirus, Salmonella enterica serovar Typhi (S. Typhi), and Rickettsia typhi. Of 537 subjects enrolled, 70% were outpatients, 54% were males, and the mean age was 37 years. Patients reported having fatigue (89%), rigors (87%), sweating (83%), pain in joints (49%), and sleep disturbances (42%). Thirty-nine (7%) patients were seropositive for R. typhi, 37 (7%) for Brucella spp., 36 (7%) for TBEV, 12 (2%) for Leptospira spp., 10 (2%) for C. burnetii, and three (0.6%) for S. Typhi. None of the febrile patients tested positive for WNV antibodies. Of the patients, 73% were negative for all pathogens. Our results indicate that most of the targeted pathogens are present in Georgia, and highlight the importance of enhancing laboratory capacity for these infectious diseases. C1 [Kuchuloria, Tinatin; Imnadze, Paata; Tsertsvadze, Tengiz] Javakhishvili Tbilisi State Univ, Tbilisi 0179, Rep of Georgia. [Imnadze, Paata; Mamuchishvili, Nana; Chokheli, Maiko] Natl Ctr Dis Control & Publ Hlth, Tbilisi, Rep of Georgia. [Tsertsvadze, Tengiz; Endeladze, Marina; Mshvidobadze, Ketevan; Gatserelia, Lana] Infect Dis AIDS & Clin Immunol Res Ctr, Tbilisi, Rep of Georgia. [Makhviladze, Manana; Kanashvili, Marine; Mikautadze, Teona] V Bochorishvili Sepsis Ctr, Tbilisi, Rep of Georgia. [Nanuashvili, Alexander; Kiknavelidze, Khatuni] Sachkhere Hosp, Sachkhere, Rep of Georgia. [Kokaia, Nora; Makharadze, Manana] S Virsaladze Res Inst Med Parasitol & Trop Med, Tbilisi, Rep of Georgia. [Clark, Danielle V.; Bautista, Christian T.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Farrell, Margaret; Fadeel, Moustafa Abdel; Maksoud, Mohamed Abdel; Pimentel, Guillermo; House, Brent] US Naval Med Res Unit 3, Global Dis Detect & Response Program, Cairo, Egypt. [Hepburn, Matthew J.; Rivard, Robert G.] US Army Med Res Inst Infect Dis, Ft Detrick, MD USA. RP Kuchuloria, T (reprint author), Javakhishvili Tbilisi State Univ, 1 Ilia Chavchavadze Ave, Tbilisi 0179, Rep of Georgia. EM drkuchuloria@yahoo.com; pimnadze@ncdc.ge; nanamamuchishvili@yahoo.com; chokhelimaiko@yahoo.com; aids@gol.ge; marinaendeladze@ymail.com; katemshvidobadze@yahoo.com; lgatserelia@yahoo.com; makhviladze_manana@yahoo.com; mkanashvili@mail.ru; mikautadze.teona@mail.ru; tamari.davitashvili@gmail.com; xatuna-kiknavelidze@rambler.ru; irma_kokaia@yahoo.com; mananamaxaradze@yahoo.com; dvclark@gmail.com; marcos.c.bautista.ctr@mail.mil; marleefar@gmail.com; moustafa.abdelfadeel.eg@med.navy.mil; mohamed.abdelmaksoud.eg@med.navy.mil; gpiment@gmail.com; brent.l.house2.mil@mail.mil; matthewhepburn@yahoo.com; robert.g.rivard.mil@mail.mil FU Global Emerging Infections Surveillance Program (GETS) FX This study was funded by the Global Emerging Infections Surveillance Program (GETS). NR 36 TC 0 Z9 0 U1 1 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JAN PY 2016 VL 94 IS 1 BP 236 EP 242 DI 10.4269/ajtmh.15-0400 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA DA3NX UT WOS:000367705500042 PM 26438032 ER PT J AU Tenan, MS Hackney, AC Griffin, L AF Tenan, Matthew S. Hackney, Anthony C. Griffin, Lisa TI Maximal force and tremor changes across the menstrual cycle SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE Menstrual cycle; Maximal force; Tremor Estrogen; Progesterone; Fatigue ID ADDUCTOR POLLICIS MUSCLE; CORTICAL EXCITABILITY; WOMEN; PERFORMANCE; PHASE; MOTOR; MEN; STRENGTH; ESTROGEN; BRAIN AB Sex hormones have profound effects on the nervous system in vitro and in vivo. The present study examines the effect of the menstrual cycle on maximal isometric force (MVC) and tremor during an endurance task. Nine eumenorrheic females participated in five study visits across their menstrual cycle. In each menstrual phase, an MVC and an endurance task to failure were performed. Tremor across the endurance task was quantified as the coefficient of variation in force and was assessed in absolute time and relative percent time to task failure. MVC decreases 23 % from ovulation to the mid luteal phase of the menstrual cycle. In absolute time, the mid luteal phase has the highest initial tremor, though the early follicular phase has substantially higher tremor than other phases after 150 s of task performance. In relative time, the mid luteal phase has the highest level of tremor throughout the endurance task. Both MVC and tremor during an endurance task are modified by the menstrual cycle. Performance of tasks and sports which require high force and steadiness to exhaustion may be decreased in the mid luteal phase compared to other menstrual phases. C1 [Tenan, Matthew S.] US Army Res Lab, RDRL HRS B, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. [Hackney, Anthony C.] Univ N Carolina, Dept Exercise & Sport Sci, Chapel Hill, NC 27599 USA. [Hackney, Anthony C.] Univ N Carolina, Sch Publ Hlth, Dept Nutr, Chapel Hill, NC 27599 USA. [Griffin, Lisa] Univ Texas Austin, Dept Kinesiol & Hlth Educ, Austin, TX 78712 USA. RP Tenan, MS (reprint author), US Army Res Lab, RDRL HRS B, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. EM matthew.s.tenan.civ@mail.mil NR 38 TC 0 Z9 0 U1 0 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1439-6319 EI 1439-6327 J9 EUR J APPL PHYSIOL JI Eur. J. Appl. Physiol. PD JAN PY 2016 VL 116 IS 1 BP 153 EP 160 DI 10.1007/s00421-015-3258-x PG 8 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA DA2FH UT WOS:000367610200015 PM 26365403 ER PT J AU McDaniel, JS Pilia, M Raut, V Ledford, J Shiels, SM Wenke, JC Barnes, B Rathbone, CR AF McDaniel, Jennifer S. Pilia, Marcello Raut, Vivek Ledford, Jeffrey Shiels, Stefanie M. Wenke, Joseph C. Barnes, Brian Rathbone, Christopher R. TI Alternatives to autograft evaluated in a rabbit segmental bone defect SO INTERNATIONAL ORTHOPAEDICS LA English DT Article DE Rabbit; Bone marrow aspirate; Segmental defect; Tricalciumphosphate; Demineralised bone matrix ID MORPHOGENETIC PROTEINS; MARROW CONCENTRATE; STEM-CELLS; REPAIR; TISSUE; MODEL; FRACTURES; CAPACITY; MUSCLE; PUTTY AB Purpose This study was designed to identify strategies for treating bone defects that can be completed on the day of surgery. Methods Forty New Zealand white rabbits with unilateral rabbit radius segmental defects (15 mm) were treated with commercially available scaffolds containing either demineralised bone matrix (DBM) or a collagen/beta-tricalcium phosphate composite (Col:beta-TCP); each scaffold was combined with either bone marrow aspirate (BMA) or concentrated BMA (cBMA). Bone regeneration was assessed through radiographic and histological analyses. Results The concentration of nucleated cells, colony-forming unit-fibroblasts and platelets were increased and haematocrit concentration decreased in cBMA as compared to BMA (p<0.05). Radiographic analyses of bone formation and defect bridging demonstrated significantly greater bone regeneration in the defects treated with DBM grafts as compared to Col:beta-TCP grafts. The healing of bones treated with Col:beta-TCP was improved when augmented with cBMA. Conclusions Scaffolds containing either DBM or Col:beta-TCP with BMA or cBMA are effective same-day strategies available to clinicians for the treatment of bone defects; the latter scaffold may be more effective if combined with cBMA. C1 [McDaniel, Jennifer S.; Pilia, Marcello; Ledford, Jeffrey; Shiels, Stefanie M.; Wenke, Joseph C.; Rathbone, Christopher R.] US Army, Extrem Trauma & Regenerat Med, Inst Surg Res, Jbsa Ft Sam Houston, TX 78234 USA. [Raut, Vivek; Barnes, Brian] Arteriocyte Med Syst, Hopkinton, MA USA. RP Rathbone, CR (reprint author), US Army, Extrem Trauma & Regenerat Med, Inst Surg Res, 3698 Chambers Pass BLDG 3611, Jbsa Ft Sam Houston, TX 78234 USA. EM chrisrathbone29@gmail.com OI Shiels, Stefanie/0000-0002-5904-3107 FU Armed Forces Institute of Regenerative Medicine; National Research Council FX The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or reflecting the views of the Department of the Army or Department of Defense. This study was supported in part by the Armed Forces Institute of Regenerative Medicine (BB). This research was supported in part by an appointment to the Student Research Participation Program at the US Army Institute of Surgical Research administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the US Department of Energy and USAMRMC (JM, SS) and the National Research Council (MP). We would like to thank Drs. Catherine Ward, Jessica Rivera and Randolph Stone for their invaluable contributions. NR 29 TC 0 Z9 0 U1 5 U2 11 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0341-2695 EI 1432-5195 J9 INT ORTHOP JI Int. Orthop. PD JAN PY 2016 VL 40 IS 1 BP 197 EP 203 DI 10.1007/s00264-015-2824-5 PG 7 WC Orthopedics SC Orthopedics GA DA4WR UT WOS:000367803400029 PM 26156711 ER PT J AU McGann, P Chahine, S Okafor, D Ong, AC Maybank, R Kwak, YI Wilson, K Zapor, M Lesho, E Hinkle, M AF McGann, Patrick Chahine, Sarah Okafor, Darius Ong, Ana C. Maybank, Rosslyn Kwak, Yoon I. Wilson, Kerry Zapor, Michael Lesho, Emil Hinkle, Mary TI Detecting 16S rRNA Methyltransferases in Enterobacteriaceae by Use of Arbekacin SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID GRAM-NEGATIVE BACTERIA; AMINOGLYCOSIDE RESISTANCE; PSEUDOMONAS-AERUGINOSA; NDM-1; RMTF; CARBAPENEMASE; PREVALENCE; INDIA; ARMA AB 16S rRNA methyltransferases confer resistance to most aminoglycosides, but discriminating their activity from that of aminoglycoside-modifying enzymes (AMEs) is challenging using phenotypic methods. We demonstrate that arbekacin, an aminoglycoside refractory to most AMEs, can rapidly detect 16S methyltransferase activity in Enterobacteriaceae with high specificity using the standard disk susceptibility test. C1 [McGann, Patrick; Chahine, Sarah; Okafor, Darius; Ong, Ana C.; Maybank, Rosslyn; Kwak, Yoon I.; Lesho, Emil; Hinkle, Mary] Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD 20910 USA. [Wilson, Kerry] Walter Reed Natl Mil Med Ctr, Infect Dis Serv, Bethesda, MD USA. [Zapor, Michael] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD USA. RP McGann, P (reprint author), Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD 20910 USA. EM patrick.t.mcgann4.ctr@mail.mil FU U.S. Army Medical Command; Global Emerging Infections Surveillance and Response System; Defense Medical Research and Development Program FX This study was funded by the U.S. Army Medical Command, the Global Emerging Infections Surveillance and Response System, and the Defense Medical Research and Development Program. NR 22 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 EI 1098-660X J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JAN PY 2016 VL 54 IS 1 BP 208 EP 211 DI 10.1128/JCM.02642-15 PG 4 WC Microbiology SC Microbiology GA DA1DX UT WOS:000367537600039 PM 26537447 ER PT J AU Fox, WP Ormond, B Williams, A AF Fox, William P. Ormond, Brendan Williams, Alex TI Ranking terrorist targets using a hybrid AHP-TOPSIS methodology SO JOURNAL OF DEFENSE MODELING AND SIMULATION-APPLICATIONS METHODOLOGY TECHNOLOGY-JDMS LA English DT Article DE Ranking terrorist targets; technique of order preference by similarity to ideal solution; analytical hierarchy process; criteria weights; pairwise comparisons; sensitivity analysis ID ANALYTIC HIERARCHY PROCESS; ATTRIBUTE DECISION-MAKING; PERFORMANCE-MEASUREMENT; ROBOT SELECTION; SENSITIVITY; MODELS AB We present a methodology and an example of preparing an order of merit list to rank terrorist targets based upon decision-maker weights. We used an old terrorist data set as our base data to keep the information unclassified. This data is used to demonstrate this methodology. We perform numerical iterative criteria weight sensitivity analysis to show the effects on the model's outputs in changes in the weights. We identify the critical criterion. C1 [Fox, William P.] Naval Postgrad Sch, Dept Def Anal, Monterey, CA 93943 USA. [Ormond, Brendan; Williams, Alex] US Army, Special Forces, San Antonio, TX USA. RP Fox, WP (reprint author), Naval Postgrad Sch, Dept Def Anal, 589 Dyer Rd,Room 103 F, Monterey, CA 93943 USA. EM wpfox@nps.edu NR 35 TC 0 Z9 0 U1 3 U2 3 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1548-5129 EI 1557-380X J9 J DEF MODEL SIMUL-AP JI J. Def. Model. Simul.-Appl. Methodol. Technol.-JDMS PD JAN PY 2016 VL 13 IS 1 BP 77 EP 93 DI 10.1177/1548512914563619 PG 17 WC Engineering, Multidisciplinary SC Engineering GA DA5IF UT WOS:000367836000007 ER PT J AU Bastian, ND Fulton, LV Griffin, PM Sung, YS Kumara, S AF Bastian, Nathaniel D. Fulton, Lawrence V. Griffin, Paul M. Sung, Yi-Shan Kumara, Soundar TI A casualty network analysis in non-major combat operations SO JOURNAL OF DEFENSE MODELING AND SIMULATION-APPLICATIONS METHODOLOGY TECHNOLOGY-JDMS LA English DT Article DE Complex networks; graph mining; network visualization; pattern recognition; military casualties; non-major combat operations AB Understanding the causes, types and locations of military casualties likely to be incurred during non-major combat operations is essential to effectively plan for medical resources required to support those operations, yet the threats posed are varied and complex. The dynamic environment that sustains non-major combat operations creates a challenge to diagnose the factors leading to casualties in these operations. We employ a network analytic approach to discover and explore the underlying casualty incident patterns in this complex, real-world operating environment. The aim of this study is to better understand the medical effect of health and irregular general threats. Discovery of these casualty incident patterns proves insightful to military medical planners and commanders. C1 [Bastian, Nathaniel D.; Sung, Yi-Shan; Kumara, Soundar] Penn State Univ, Dept Ind & Mfg Engn, Ctr Integrated Healthcare Delivery Syst, University Pk, PA 16802 USA. [Bastian, Nathaniel D.] US Mil Acad, Network Sci Ctr, Dept Math Sci, West Point, NY 10996 USA. [Bastian, Nathaniel D.; Fulton, Lawrence V.] Texas Tech Univ, Rawls Coll Business Adm, Ctr Healthcare Innovat Educ & Res, Lubbock, TX 79409 USA. [Bastian, Nathaniel D.; Griffin, Paul M.] Georgia Inst Technol, Ctr Hlth & Humanitarian Syst, H Milton Stewart Sch Ind & Syst Engn, Atlanta, GA 30332 USA. RP Bastian, ND (reprint author), Penn State Univ, Dept Ind & Mfg Engn, Ctr Integrated Healthcare Delivery Syst, 355 Leonhard Bldg, University Pk, PA 16802 USA. EM ndbastian@psu.edu NR 28 TC 0 Z9 0 U1 0 U2 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1548-5129 EI 1557-380X J9 J DEF MODEL SIMUL-AP JI J. Def. Model. Simul.-Appl. Methodol. Technol.-JDMS PD JAN PY 2016 VL 13 IS 1 BP 95 EP 108 DI 10.1177/1548512915585885 PG 14 WC Engineering, Multidisciplinary SC Engineering GA DA5IF UT WOS:000367836000008 ER PT J AU Jackson, SJT Singletary, KW Murphy, LL Venema, RC Young, AJ AF Jackson, Steven J. T. Singletary, Keith W. Murphy, Laura L. Venema, Richard C. Young, Andrew J. TI Phytonutrients Differentially Stimulate NAD(P)H: Quinone Oxidoreductase, Inhibit Proliferation, and Trigger Mitotic Catastrophe in Hepa1c1c7 Cells SO JOURNAL OF MEDICINAL FOOD LA English DT Article DE cell cycle; curcumin; quercetin; resveratrol; sulforaphane ID JET FUEL; MICROTUBULE POLYMERIZATION; TUBULIN POLYMERIZATION; FOOD PHYTOCHEMICALS; ENDOTHELIAL-CELLS; CLINICAL-TRIAL; SULFORAPHANE; NRF2; PROGRESSION; PROTECTION AB Phytonutrients have rapidly emerged as natural food chemicals possessing multifaceted biological actions that may support beneficial health outcomes. Among the vast array of phytonutrients currently being studied, sulforaphane, curcumin, quercetin, and resveratrol have been frequently reported to stimulate the expression of endogenous detoxification enzymes and may thereby facilitate the neutralization of otherwise harmful environmental agents. Some of these same phytonutrients, however, have also been implicated in disrupting normal cell proliferation and hence may possess toxic properties in and of themselves. In this study, we characterize the respective minimum threshold concentrations of the aforementioned phytonutrients in Hepa1c1c7 cells that stimulate NAD(P)H:quinone oxidoreductase (NQO1), a key enzyme in the hepatic neutralization of menadione, other biological oxidants, and some environmental carcinogens. Moreover, our findings demonstrate that relatively low concentrations of either sulforaphane or curcumin significantly (P<.05) increase NQO1 protein expression and activity without triggering G(2)/M cell cycle arrest or mitotic catastrophe. The minimal quercetin concentration inducing NQO1, however, was 100-fold higher than that which disrupted mitosis. Also, while resveratrol modestly stimulated NQO1, the minimally effective resveratrol concentration concomitantly induced evidence of cellular apoptosis. Taken together, these findings indicate that only particular phytonutrients are likely efficacious in upregulating NQO1 activity without also leading to hepatic cytotoxicity. C1 [Jackson, Steven J. T.] US Army, Aeromed Res Lab, Aircrew Hlth & Performance Div, Fort Rucker, AL USA. [Singletary, Keith W.] Univ Illinois, Dept Food Sci & Human Nutr, Urbana, IL 61801 USA. [Murphy, Laura L.] So Illinois Univ, Dept Physiol, Carbondale, IL USA. [Venema, Richard C.] Georgia Regents Univ, Med Coll Georgia, Vasc Biol Ctr, Augusta, GA USA. [Young, Andrew J.] US Army, Environm Med Res Inst, Mil Nutr Div, Natick, MA USA. RP Jackson, SJT (reprint author), Archer Daniels Midland Co, 4666 Faries Pkwy, Decatur, GA 62526 USA. EM steven.jackson@adm.com FU U.S. Army Medical Research and Materiel Command, In-house Laboratory Independent Research Program (ILIR) FX This study was supported by the U.S. Army Medical Research and Materiel Command, In-house Laboratory Independent Research Program (ILIR). NR 41 TC 1 Z9 1 U1 4 U2 4 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1096-620X EI 1557-7600 J9 J MED FOOD JI J. Med. Food PD JAN 1 PY 2016 VL 19 IS 1 BP 47 EP 53 DI 10.1089/jmf.2015.0079 PG 7 WC Chemistry, Medicinal; Food Science & Technology; Nutrition & Dietetics SC Pharmacology & Pharmacy; Food Science & Technology; Nutrition & Dietetics GA DA5EF UT WOS:000367824700006 PM 26623679 ER PT J AU Keller, CB Bielakowski, R AF Keller, Christian B. Bielakowski, Rae TI Hungarian Emigres in the American Civil War: A History and Biographical Dictionary SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Keller, Christian B.] US Army War Coll, Carlisle, PA 17013 USA. RP Keller, CB (reprint author), US Army War Coll, Carlisle, PA 17013 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 EI 1543-7795 J9 J MILITARY HIST JI J. Mil. Hist. PD JAN PY 2016 VL 80 IS 1 BP 208 EP 211 PG 4 WC History SC History GA DA3NB UT WOS:000367703300020 ER PT J AU Barbuto, RV AF Barbuto, Richard V. TI Shays's Rebellion: Authority and Distress in Post-Revolutionary America SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Barbuto, Richard V.] US Army, Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. RP Barbuto, RV (reprint author), US Army, Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 2 U2 2 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 EI 1543-7795 J9 J MILITARY HIST JI J. Mil. Hist. PD JAN PY 2016 VL 80 IS 1 BP 236 EP 237 PG 2 WC History SC History GA DA3NB UT WOS:000367703300036 ER PT J AU Marzoli, NA AF Marzoli, Nathan A. TI The First Battle for Petersburg: The Attack and Defense of the Cockade City, June 9, 1864. SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Marzoli, Nathan A.] US Army, Ctr Mil Hist, Washington, DC 20024 USA. RP Marzoli, NA (reprint author), US Army, Ctr Mil Hist, Washington, DC 20024 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 EI 1543-7795 J9 J MILITARY HIST JI J. Mil. Hist. PD JAN PY 2016 VL 80 IS 1 BP 244 EP 245 PG 2 WC History SC History GA DA3NB UT WOS:000367703300042 ER PT J AU Bjorge, GJ AF Bjorge, Gary J. TI Where Chiang Kai-shek Lost China: The Liao-Shen Campaign. SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Bjorge, Gary J.] US Army Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. RP Bjorge, GJ (reprint author), US Army Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 EI 1543-7795 J9 J MILITARY HIST JI J. Mil. Hist. PD JAN PY 2016 VL 80 IS 1 BP 295 EP 296 PG 2 WC History SC History GA DA3NB UT WOS:000367703300076 ER PT J AU Schneider, BA AF Schneider, Brent A. TI Cost-Effective Solutions to Mental Health Barriers Attributable to Budgetary and Qualified Personnel Inefficiencies SO JOURNAL OF NERVOUS AND MENTAL DISEASE LA English DT Letter C1 [Schneider, Brent A.] US Army, Universal City, TX USA. RP Schneider, BA (reprint author), US Army, Universal City, TX USA. EM brentschneider@g.harvard.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0022-3018 EI 1539-736X J9 J NERV MENT DIS JI J. Nerv. Ment. Dis. PD JAN PY 2016 VL 204 IS 1 BP 68 EP 68 DI 10.1097/NMD.0000000000000410 PG 1 WC Clinical Neurology; Psychiatry SC Neurosciences & Neurology; Psychiatry GA DA5DR UT WOS:000367823100016 PM 26704467 ER PT J AU Sondeen, JL Hanson, MA Prince, MD de Guzman, R Polykratis, IA Aden, JK Cap, AP Dubick, MA AF Sondeen, Jill L. Hanson, Margaret A. Prince, Malcolm D. de Guzman, Rodolfo Polykratis, Irene A. Aden, James K. Cap, Andrew P. Dubick, Michael A. TI Double-blinded, placebo-controlled study of early tranexamic acid treatment in swine uncontrolled hemorrhage model SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Hemorrhagic shock; swine; tranexamic acid; combat casualty care; plasma ID TRAUMA PATIENTS; CONTROLLED-TRIAL; KNOWLEDGE GAPS; RESUSCITATION; TRANSFUSION; ACTIVATION; MORTALITY; PROMMTT; CRASH-2; IMPACT AB BACKGROUND Tranexamic acid (TXA) is an antifibrinolytic drug that was shown to increase survival in trauma patients, but the mechanisms remain unclear. The purpose of this double-blinded, randomized placebo-controlled study was to determine if TXA with hypotensive resuscitation with Hextend (HEX) or fresh frozen plasma (FFP) reduced blood loss (BL) and improved survival in a model of uncontrolled hemorrhage. METHODS Instrumented, anesthetized pigs (n = 11 per group) were subjected to 24-mL/kg controlled hemorrhage, followed by transection of the spleen. After 15 minutes of bleeding, TXA (1.43 mg/kg/min) or normal saline (NS) was given over 10 minutes, and then 15-mL/kg HEX or FFP was administered. At 90 minutes, a second infusion of TXA or NS was given. BL, coagulation status, and 5-hour survival were determined. Tissue plasminogen activator (tPA) was added to blood samples collected before and after TXA administration to confirm that the TXA inhibited fibrinolysis. In addition, a comparison of a dose response to tPA-induced fibrinolysis was made between swine and human plasma in vitro. RESULTS TXA prevented the rise in d-dimers that occurred after spleen injury. However, there was no significant effect of TXA on survival or BL compared with NS with HEX (HEX + NS, 17 2 mL/kg vs. HEX + TXA, 17 +/- 2 mL/kg) or FFP (FFP + NS, 7 +/- 2 mL/kg vs. FFP + TXA, 12 +/- 3 mL/kg), while FFP significantly reduced BL and increased survival compared with HEX in the NS-treated animals. The tPA-induced fibrinolysis was inhibited in the blood from TXA-treated animals, yet in fibrinolysis sensitivity studies, human plasma was 30 times more sensitive to tPA-induced fibrinolysis than swine plasma. CONCLUSION TXA did not reduce BL, even though TXA was antifibrinolytic in the pigs. The possibility remains that the pig is highly resistant to fibrinolysis and not a good model to study the effects of antifibrinolytics or that fibrinolysis is not a major factor in bleeding from splenic injury. C1 [Sondeen, Jill L.; Hanson, Margaret A.; Prince, Malcolm D.; de Guzman, Rodolfo; Polykratis, Irene A.; Aden, James K.; Cap, Andrew P.; Dubick, Michael A.] US Army Inst Surg Res, San Antonio, TX 78234 USA. RP Dubick, MA (reprint author), US Army Inst Surg Res, San Antonio, TX 78234 USA. EM Michael.a.dubick.civ@mail.mil NR 24 TC 1 Z9 1 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD JAN PY 2016 VL 80 IS 1 BP 81 EP 88 DI 10.1097/TA.0000000000000860 PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA DA1GN UT WOS:000367544400012 PM 26683393 ER PT J AU Ramakrishnan, S Wesensten, NJ Balkin, TJ Reifman, J AF Ramakrishnan, Sridhar Wesensten, Nancy J. Balkin, Thomas J. Reifman, Jaques TI A Unified Model of Performance: Validation of its Predictions across Different Sleep/Wake Schedules SO SLEEP LA English DT Article DE biomathematical model; chronic sleep restriction; naps; PVT; total sleep deprivation; two-process model ID MATHEMATICAL-MODEL; NEUROBEHAVIORAL PERFORMANCE; DOSE-RESPONSE; RESTRICTION; DEPRIVATION; FATIGUE; SLEEPINESS; VIGILANCE; RECOVERY; VULNERABILITY AB Study Objectives: Historically, mathematical models of human neurobehavioral performance developed on data from one sleep study were limited to predicting performance in similar studies, restricting their practical utility. We recently developed a unified model of performance (UMP) to predict the effects of the continuum of sleep loss-from chronic sleep restriction (CSR) to total sleep deprivation (TSD) challenges-and validated it using data from two studies of one laboratory. Here, we significantly extended this effort by validating the UMP predictions across a wide range of sleep/wake schedules from different studies and laboratories. Methods: We developed the UMP on psychomotor vigilance task (PVT) lapse data from one study encompassing four different CSR conditions (7 d of 3, 5, 7, and 9 h of sleep/night), and predicted performance in five other studies (from four laboratories), including different combinations of TSD (40 to 88 h), CSR (2 to 6 h of sleep/night), control (8 to 10 h of sleep/night), and nap (nocturnal and diurnal) schedules. Results: The UMP accurately predicted PVT performance trends across 14 different sleep/wake conditions, yielding average prediction errors between 7% and 36%, with the predictions lying within 2 standard errors of the measured data 87% of the time. In addition, the UMP accurately predicted performance impairment (average error of 15%) for schedules (TSD and naps) not used in model development. Conclusions: The unified model of performance can be used as a tool to help design sleep/wake schedules to optimize the extent and duration of neurobehavioral performance and to accelerate recovery after sleep loss. C1 [Ramakrishnan, Sridhar; Reifman, Jaques] US Army Med Res & Mat Command, Dept Def, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. [Wesensten, Nancy J.; Balkin, Thomas J.] Walter Reed Army Inst Res, Dept Behav Biol, Silver Spring, MD USA. RP Reifman, J (reprint author), US Army Med Res & Mat Command, Dept Def, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr,ATTN MCMR TT, 504 Scott St, Ft Detrick, MD 21702 USA. EM jaques.reifman.civ@mail.mil FU Military Operational Medicine Research Area Directorate of the U.S. Army Medical Research and Materiel Command, Ft. Detrick, MD; US Department of Defense Medical Research and Development Program [DMRDP_13200] FX This was not an industry supported study. This work was sponsored by the Military Operational Medicine Research Area Directorate of the U.S. Army Medical Research and Materiel Command, Ft. Detrick, MD, and by the US Department of Defense Medical Research and Development Program (Grant No. DMRDP_13200). The authors have indicated no financial conflicts of interest. The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U.S. Army or of the U.S. Department of Defense. This paper has been approved for public release with unlimited distribution. NR 34 TC 2 Z9 2 U1 2 U2 3 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 EI 1550-9109 J9 SLEEP JI Sleep PD JAN 1 PY 2016 VL 39 IS 1 BP 249 EP 262 DI 10.5665/sleep.5358 PG 14 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA DA0VM UT WOS:000367515700031 PM 26518594 ER PT J AU Gandhi, RT Bosch, RJ Rangsin, R Chuenchitra, T Sirisopana, N Kim, JH Robb, ML Vejbaesya, S Paris, RM Nelson, KE AF Gandhi, Rajesh T. Bosch, Ronald J. Rangsin, Ram Chuenchitra, Thippawan Sirisopana, Narongrid Kim, Jerome H. Robb, Merlin L. Vejbaesya, Sasijit Paris, Robert M. Nelson, Kenrad E. TI HLA Class I Alleles Associated with Mortality in Thai Military Recruits with HIV-1 CRF01_AE Infection SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID YOUNG MEN; NATURAL-HISTORY; AIDS; SEROCONVERSION; TRANSMISSION; PROGRESSION; FREQUENCY; DRB1; KIR AB In HIV-1-infected patients, variation at the HLA class I locus is associated with disease progression, but few studies have assessed the influence of HLA alleles on HIV-1 CRF01_AE infection, which is dominant in Thailand. We hypothesized that alleles predicted to confer more effective immune responses, such as HLA-B*46, would protect against disease progression. HLA typing was performed on HIV-1 incident cases surviving until 1998-1999 and HIV-1-negative matched controls from Thai army cohorts enrolled between 1991 and 1995. We assessed associations between class I alleles and disease progression subsequent to HLA typing. Ninety-nine HIV-1-incident cases were followed for a median of 3.7 years after HLA typing; during this time, 58 participants died. Two alleles were associated with mortality: HLA B*51 was protective (3-year survival B*51(pos) vs. B*51(neg): 75% vs. 52%; p=0.034) whereas Cw*04 was deleterious (3-year survival Cw*04(pos) vs. Cw*04(neg): 39% vs. 60%; p=0.027). HLA-B*46 was not associated with disease progression. Alleles present at different frequencies in HIV-1-incident compared with HIV-1-negative men included HLA-A*02:03, B*35, B*15, and C*08. 1. In conclusion in this Thai army cohort, HLA-B*51 was associated with lower mortality, confirming that this allele, which is protective in clade B HIV-1 infection, has a similar effect on HIV CRF01_AE infection. The deleterious effect of HLA-Cw*04 must be interpreted with caution because it may be in linkage disequilibrium with disease-susceptible HLA-B alleles. We did not find that HLA-B*46 was protective. These findings may inform vaccine development for areas of the world in which HIV-1 CRF01_AE infection is prevalent. C1 [Gandhi, Rajesh T.] Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02114 USA. [Gandhi, Rajesh T.] MIT & Harvard, Massachusetts Gen Hosp, Ragon Inst, Cambridge, MA USA. [Bosch, Ronald J.] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA. [Rangsin, Ram] Phramongkutklao Coll Med, Dept Mil & Community Med, Bangkok, Thailand. [Chuenchitra, Thippawan; Sirisopana, Narongrid] AFRIMS, Div Res, Royal Thai Army, Bangkok, Thailand. [Kim, Jerome H.; Robb, Merlin L.] Int Vaccine Inst, Seoul, South Korea. [Robb, Merlin L.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Vejbaesya, Sasijit] Siriraj Hosp, Dept Transfus Med, Fac Med, Bangkok, Thailand. [Paris, Robert M.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Paris, Robert M.] Walter Reed Army Inst Res, Mil Malaria Res Program, Silver Spring, MD USA. [Nelson, Kenrad E.] Johns Hopkins Univ, Dept Epidemiol, Bloomberg Sch Publ Hlth, Baltimore, MD USA. RP Gandhi, RT (reprint author), Massachusetts Gen Hosp, GRJ 504,55 Fruit St, Boston, MA 02114 USA. EM rgandhi@mgh.harvard.edu FU Henry M. Jackson Foundation for the Advancement of Military Medicine [W81XWH-07-2-0067]; U.S. Department of Defense [W81XWH-07-2-0067]; National Institutes of Health [NIAID 5P30AI060354-08] FX This work was supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine and the U.S. Department of Defense, and by the National Institutes of Health-funded Harvard University Center for AIDS Research (NIAID 5P30AI060354-08). The opinions or assertions contained herein are the private views of the authors, and are not to be construed as official, or as reflecting true views or positions of the United States Army or the Department of Defense. We would like to thank Neha Patel for her assistance in preparing this manuscript. We would like to express our appreciation for reviewer comments that strengthened the manuscript. NR 24 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD JAN 1 PY 2016 VL 32 IS 1 BP 44 EP 49 DI 10.1089/aid.2015.0120 PG 6 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA CZ8FH UT WOS:000367335100007 PM 26383907 ER PT J AU Atwood, CA Goebbert, RC Calahan, JA Hromadka, TV Proue, TM Monceaux, W Hirata, J AF Atwood, Christopher A. Goebbert, Randy C. Calahan, Joshua A. Hromadka, Theodore V., III Proue, Thomas M. Monceaux, Weston Hirata, Jason TI Secure Web-Based Access for Productive Supercomputing SO COMPUTING IN SCIENCE & ENGINEERING LA English DT Article AB US Department of Defense High Performance Computing Modernization Program communities are increasingly in need of access to highly capable computing, networking, storage, and software resources from their user enclaves that are administratively prevented from installation of applications due to malicious software risks. The HPC Portal enables a productive and secure computational science environment. C1 [Atwood, Christopher A.] US Dept Def, High Performance Comp Modernizat Program, Washington, DC 20301 USA. [Goebbert, Randy C.] Integr Applicat Inc, HPC Portal Dev Team, Chantilly, VA USA. [Calahan, Joshua A.] Arctic Slope Reg Corp ASRC Fed InuTeq, Barrow, AK USA. [Hromadka, Theodore V., III] Integr Applicat Inc, HPC Portal Project, Chantilly, VA USA. [Monceaux, Weston] US Army Corps Engineers, Engineer Res Dev Ctr, Informat Technol Lab, Washington, DC USA. [Hirata, Jason] Integr Applicat Inc, HPC Portal Project, Pacific Def Solut, Chantilly, VA USA. RP Atwood, CA (reprint author), US Dept Def, High Performance Comp Modernizat Program, Washington, DC 20301 USA. EM chris.atwood@hpc.mil; rgoebbert@integrity-apps.com; joshua.calahan.ctr@hpc.mil; thromadka@integrity-apps.com; tom.proue.ctr@dren.hpc.mil; weston.p.monceaux@usace.army.mil; jhirata@integrity-apps.com FU Department of Defense High Performance Computing Modernization Program (HPCMP) FX We thank the Department of Defense High Performance Computing Modernization Program (HPCMP) for funding the HPC Portal effort; we also thank the Maui High Performance Computing Center (MHPCC), Engineer Research and Development Center (ERDC), and HPCMP CREATE for development team hosting and collaboration. NR 9 TC 1 Z9 1 U1 0 U2 0 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 1521-9615 EI 1558-366X J9 COMPUT SCI ENG JI Comput. Sci. Eng. PD JAN-FEB PY 2016 VL 18 IS 1 BP 63 EP 72 PG 10 WC Computer Science, Interdisciplinary Applications SC Computer Science GA CZ7DS UT WOS:000367260700007 ER PT J AU Wouters, N Serafim, MP Valayer, PJ Kirkup, BC Wang, YJ Cabral, HN AF Wouters, N. Serafim, M. P. Valayer, P. J. Kirkup, B. C. Wang, Y. J. Cabral, H. N. TI Early warning signals as indicators of cyclostationarity in three-species hierarchies SO ECOLOGICAL INDICATORS LA English DT Article DE Automaton; Patchiness; Early warning signal; Stability; Cyclic; Autocorrelation; Standard deviation ID ROCK-PAPER-SCISSORS; CRITICAL SLOWING-DOWN; ANTIBIOTIC PRODUCTION; COMPETITIVE NETWORKS; POPULATION COLLAPSE; TIPPING POINTS; ECOSYSTEMS; DYNAMICS; CLIMATE; SHIFTS AB Predicting stability from current ecosystem performance is theoretically difficult, but early statistical warning signals (EWS) may enable the anticipation of regime shifts. However, little is known regarding the behavior of EWS in shifts with cyclic dynamics. In this study, we use indicators to assess the stability of a three-species system in a competitive loop similar to a rock-paper-scissors (RPS) hierarchy. In two scenarios, the RPS is simulated using a 3-D automaton whose input matrix combines probabilities of pair-wise dominance with differential reaction frequencies. The first scenario uses the data of a microbial experiment in which the RPS hierarchy is characterized by incomplete dominance within species pairs and differences in reaction frequency between species pairs. The input of the second model was chosen to generate a contrasting scenario: a symmetric RPS interaction gradually subjected to a stressor. The reaction frequency of one species pair was modeled to decay linearly over time. The relative species abundances are monitored spatiotemporally. In the first scenario, abundances oscillate stably despite initial large swings, whereas in the second scenario, one species gradually dominates, eventually resulting in transitivity. In both scenarios, species cluster spatially in patches of single species. In scenario I, the average patch size remains constant throughout the iterations and possibly contributes to the overall stability; however, in the second scenario, a further homogenization takes place. In the first scenario, EWS reflected the system's stability with species abundances settling into a stable basin. In scenario I only one of the EWS indicators detected consistently the loss of resilience. Sensitivity analysis revealed excessive variability in dominance resulted in immediate loss of the RPS hierarchy. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Wouters, N.; Serafim, M. P.; Cabral, H. N.] Univ Lisboa Campo Grande, MARE Marine & Environm Sci Ctr, Fac Ciencias, P-1749016 Lisbon, Portugal. [Wouters, N.; Valayer, P. J.] Biomim Greenloop, B-1000 Brussels, Belgium. [Kirkup, B. C.] MIT, Dept Civil & Environm Engn, Boston, MA 02139 USA. [Kirkup, B. C.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Kirkup, B. C.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Wang, Y. J.] Rutgers State Univ, Dept Math Sci, Camden, NJ 08102 USA. [Wouters, N.; Serafim, M. P.; Cabral, H. N.] Univ Lisbon, Dept Biol Anim, Fac Ciencias, P-1749016 Lisbon, Portugal. RP Wouters, N (reprint author), Univ Lisboa Campo Grande, MARE Marine & Environm Sci Ctr, Fac Ciencias, P-1749016 Lisbon, Portugal. EM nwouters@fc.ul.pt RI Cabral, Henrique/D-5201-2011; Kirkup, Benjamin/C-3610-2009 OI Cabral, Henrique/0000-0002-7646-6208; Kirkup, Benjamin/0000-0002-8722-6218 FU Fundacao para a Ciencia e a Tecnologia [BD/48402/2008] FX The first author was funded by a PhD fellowship of Fundacao para a Ciencia e a Tecnologia with reference number BD/48402/2008. NR 46 TC 2 Z9 2 U1 2 U2 9 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1470-160X EI 1872-7034 J9 ECOL INDIC JI Ecol. Indic. PD JAN PY 2016 VL 60 BP 586 EP 593 DI 10.1016/j.ecolind.2015.06.038 PG 8 WC Biodiversity Conservation; Environmental Sciences SC Biodiversity & Conservation; Environmental Sciences & Ecology GA CZ9GW UT WOS:000367407000060 ER PT J AU Pearlstine, L Lo Galbo, A Reynolds, G Parsons, JH Dean, T Alvarado, M Suir, K AF Pearlstine, Leonard Lo Galbo, Alicia Reynolds, Gregg Parsons, Janice Holly Dean, Tylan Alvarado, Mario Suir, Kevin TI Recurrence intervals of spatially simulated hydrologic metrics for restoration of Cape Sable seaside sparrow (Ammodramus maritimus mirabilis) habitat SO ECOLOGICAL INDICATORS LA English DT Article DE Cape Sable seaside sparrow; Ammodramus maritimus mirabilis; Florida; Everglades; Marl prairie; Habitat model; Hydrologic suitability ID VEGETATION; MANAGEMENT AB Marl prairie, a diverse graminoid-dominated freshwater vegetation community in the Florida Everglades, provides a specialized niche for the federally endangered Cape Sable seaside sparrow (CSSS). This paper describes a regional habitat suitability modeling approach to evaluating how changes in management from Everglades restoration may affect the CSSS. The Cape Sable Seaside Sparrow Marl Prairie Indicator (CSSSMarlPrairie) is a spatially explicit model that integrates frequency (return periods) of target hydrologic conditions to simulate the anticipated response of marl prairie CSSS habitats to fluxing hydropatterns resulting from restoration projects, water management operations, and climatic change. The model integrates CSSS field survey data with the hydrologic targets at the resolution of the hydrologic simulation model (in this case, the Regional Simulation Model). The application of return periods for hydrologic events provides a novel approach for simulation of anticipated marl prairie responses in the southern Everglades and is readily applicable to evaluating targets-of modeled wetland restoration scenarios elsewhere. CSSSMarlPrairie is intended to be used for decision support, in association with a suite of ecological models for additional species of management concern, to facilitate planning of ecosystem restoration projects such as those in the Comprehensive Everglades Restoration Plan and recovery of the marl prairie habitats of the CSSS. A tentatively selected restoration plan for the central Everglades is projected to have mostly minor overall impacts to marl prairie CSSS habitats. Local substantial habitat shifts in and adjacent to designated habitat boundaries have been identified, however, that warrant management consideration. Published by Elsevier Ltd. C1 [Pearlstine, Leonard; Reynolds, Gregg; Parsons, Janice Holly; Dean, Tylan; Alvarado, Mario] Natl Pk Serv, South Florida Nat Resources Ctr, Homestead, FL 33030 USA. [Lo Galbo, Alicia] US Army Corps Engineers, Planning & Policy Branch, Div Water Resources, Norfolk, VA 23510 USA. [Suir, Kevin] US Geol Survey, Natl Wetlands Res Ctr, Lafayette, LA 70506 USA. RP Pearlstine, L (reprint author), Natl Pk Serv, South Florida Nat Resources Ctr, Everglades Natl Pk, Homestead, FL 33030 USA. EM Leonard_Pearlstine@nps.gov NR 28 TC 0 Z9 0 U1 1 U2 11 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1470-160X EI 1872-7034 J9 ECOL INDIC JI Ecol. Indic. PD JAN PY 2016 VL 60 BP 1252 EP 1262 DI 10.1016/j.ecolind.2015.09.018 PG 11 WC Biodiversity Conservation; Environmental Sciences SC Biodiversity & Conservation; Environmental Sciences & Ecology GA CZ9GW UT WOS:000367407000124 ER PT J AU Skukalek, SL Winkler, AM Kang, J Dion, JE Cawley, CM Webb, A Dannenbaum, MJ Schuette, AJ Asbury, B Tong, FC AF Skukalek, Susana L. Winkler, Anne M. Kang, Jian Dion, Jacques E. Cawley, C. Michael Webb, Adam Dannenbaum, Mark J. Schuette, Albert J. Asbury, Bill Tong, Frank C. TI Effect of antiplatelet therapy and platelet function testing on hemorrhagic and thrombotic complications in patients with cerebral aneurysms treated with the pipeline embolization device: a review and meta-analysis SO JOURNAL OF NEUROINTERVENTIONAL SURGERY LA English DT Article DE Aneurysm; Complication; Flow Diverter ID SINGLE-CENTER EXPERIENCE; TERM-FOLLOW-UP; INTRACRANIAL ANEURYSMS; ENDOVASCULAR TREATMENT; RECONSTRUCTION; CLOPIDOGREL; TRIAL; STENT AB Purpose The pipeline embolization device (PED) necessitates dual antiplatelet therapy (APT) to decrease thrombotic complications while possibly increasing bleeding risks. The role of APT dose, duration, and response in patients with hemorrhagic and thromboembolic events warrants further analysis. Methods A PubMed and Google Scholar search from 2009 to 2014 was performed using the following search terms individually or in combination: pipeline embolization device, aneurysm(s), and flow diversion, excluding other flow diverters. Review of the bibliographies of the retrieved articles yielded 19 single and multicenter studies. A statistical meta-analysis between aspirin (ASA) dose (low dose 160mg, high dose 300mg), loading doses of APT agents, post-PED APT regimens, and platelet function testing (PFT) with hemorrhagic or thrombotic complications was performed. Results ASA therapy for 6months post-PED was associated with increased hemorrhagic events. High dose ASA 6months post-PED was associated with fewer thrombotic events compared with low dose ASA. Post-PED clopidogrel for 6months demonstrated an increased incidence of symptomatic thrombotic events. Loading doses of ASA plus clopidogrel demonstrated a decreased incidence of permanent symptomatic hemorrhagic events. PFT did not show a statistically significant relationship with symptomatic hemorrhagic or thrombotic complications. Conclusions High dose ASA >6months is associated with fewer permanent thrombotic and hemorrhagic events. Clopidogrel therapy 6months is associated with higher rates of thrombotic events. Loading doses of ASA and clopidogrel were associated with a decreased incidence of hemorrhagic events. PFT did not have any significant association with symptomatic events. C1 [Skukalek, Susana L.] Emory Clin, Dept Neurosurg, Atlanta, GA 30322 USA. [Skukalek, Susana L.] Emory Clin, Dept Radiol, Atlanta, GA 30322 USA. [Winkler, Anne M.] Emory Univ, Sch Med, Dept Pathol & Lab Med, Atlanta, GA 30322 USA. [Kang, Jian] Emory Rollins Sch Publ Hlth, Dept Biostat & Bioinformat, Atlanta, GA USA. [Dion, Jacques E.; Cawley, C. Michael; Tong, Frank C.] Emory Univ, Sch Med, Dept Radiol, Atlanta, GA 30322 USA. [Dion, Jacques E.; Cawley, C. Michael; Webb, Adam; Tong, Frank C.] Emory Univ, Sch Med, Dept Neurosurg, Atlanta, GA USA. [Webb, Adam] Emory Univ, Sch Med, Dept Neurol, Atlanta, GA 30322 USA. [Dannenbaum, Mark J.] Univ Texas Houston, Dept Neurosurg, Houston, TX USA. [Schuette, Albert J.] Tripler Army Med Ctr, Dept Neurosurg, Honolulu, HI 96859 USA. [Asbury, Bill] Emory Univ Hosp, Atlanta, GA 30322 USA. RP Skukalek, SL (reprint author), Emory Clin, Dept Neurosurg, 1365B Clifton Rd,Suite 2200, Atlanta, GA 30322 USA. EM susana.skukalek@emoryhealthcare.org NR 24 TC 3 Z9 4 U1 0 U2 1 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1759-8478 EI 1759-8486 J9 J NEUROINTERV SURG JI J. NeuroInterventional Surg. PD JAN PY 2016 VL 8 IS 1 BP 58 EP 65 DI 10.1136/neurintsurg-2014-011145 PG 8 WC Neuroimaging; Surgery SC Neurosciences & Neurology; Surgery GA DA0IH UT WOS:000367480300016 PM 25385746 ER PT J AU Tandon, R Cucchiaro, J Phillips, D Hernandez, D Mao, YC Pikalov, A Loebel, A AF Tandon, Rajiv Cucchiaro, Josephine Phillips, Debra Hernandez, David Mao, Yongcai Pikalov, Andrei Loebel, Antony TI A double-blind, placebo-controlled, randomized withdrawal study of lurasidone for the maintenance of efficacy in patients with schizophrenia SO JOURNAL OF PSYCHOPHARMACOLOGY LA English DT Article DE Lurasidone; schizophrenia; relapse prevention; maintenance treatment; antipsychotic agents; drug therapy ID CONTROLLED TRIAL; RATING-SCALE; 160 MG/DAY; OPEN-LABEL; PREVENTION; RELAPSE; OLANZAPINE; TOLERABILITY; METAANALYSIS; EXTENSION AB Objective: To evaluate the effectiveness of lurasidone as maintenance treatment for schizophrenia. Method: Adults experiencing an acute exacerbation of schizophrenia initially received 12-24 weeks of open-label treatment with lurasidone (40-80 mg/d, flexibly dosed). Patients who maintained clinical stability for 12 weeks were randomized in double-blind fashion to placebo or lurasidone (40-80 mg/d, flexibly dosed) for an additional 28-week treatment period. The primary efficacy endpoint was time to relapse (based on Kaplan-Meier survival analysis). Results: A total of 676 patients enrolled in the open-label phase; 285 met protocol-specified stabilization criteria and were randomized to lurasidone (N=144) or placebo (N=141). During the open-label phase, mean Positive and Negative Syndrome Scale total score decreased from 90.1 to 54.4 in patients who met clinical stability criteria and were randomized. In the double-blind phase, lurasidone significantly delayed time to relapse compared with placebo (log-rank test, p=0.039), reflecting a 33.7% reduction in risk of relapse (Cox hazard ratio (95% confidence interval), 0.663 (0.447-0.983); p=0.041). Probability of relapse at the double-blind week 28 endpoint (based on Kaplan-Meier analysis) was 42.2% in the lurasidone group and 51.2% in the placebo group. Minimal changes in weight, lipid, glucose, and prolactin were observed throughout the study. Conclusions: This multicenter, placebo-controlled, randomized withdrawal study demonstrated the efficacy of lurasidone for the maintenance treatment of patients with schizophrenia. C1 [Tandon, Rajiv] Univ Florida, Coll Med, Gainesville, FL 32608 USA. [Cucchiaro, Josephine; Phillips, Debra; Hernandez, David; Mao, Yongcai; Pikalov, Andrei; Loebel, Antony] Sunov Pharmaceut Inc, Ft Lee, VA USA. [Cucchiaro, Josephine; Phillips, Debra; Hernandez, David; Mao, Yongcai; Pikalov, Andrei; Loebel, Antony] Sunov Pharmaceut Inc, Marlborough, NJ USA. RP Tandon, R (reprint author), Univ Florida, Coll Med, Psychiat, 1600 SW Archer Rd, Gainesville, FL 32608 USA. EM tandon@ufl.edu FU Sunovion Pharmaceuticals, Inc.; Takeda Pharmaceuticals International, Inc. FX The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Clinical research was sponsored by Sunovion Pharmaceuticals, Inc. and Takeda Pharmaceuticals International, Inc. The sponsors were involved in the study design, collection, and analysis of data. The interpretation of results and the decision to submit this manuscript for publication in the Journal of Psychopharmacology were made by the authors independently. NR 36 TC 2 Z9 2 U1 1 U2 4 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0269-8811 EI 1461-7285 J9 J PSYCHOPHARMACOL JI J. Psychopharmacol. PD JAN PY 2016 VL 30 IS 1 BP 69 EP 77 DI 10.1177/0269881115620460 PG 9 WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry GA CZ8XL UT WOS:000367382300009 PM 26645209 ER PT J AU Henry, TC Bakis, CE Riddick, JC AF Henry, Todd C. Bakis, Charles E. Riddick, Jaret C. TI Three-dimensional elastic behavior of undulating laminas in fiber composites SO JOURNAL OF REINFORCED PLASTICS AND COMPOSITES LA English DT Article DE Homogenization; composites; undulation; anisotropy ID WOVEN FABRIC COMPOSITES; TEXTILE STRUCTURAL COMPOSITES; PREDICTION; STIFFNESS; CONSTANTS; MODELS; MODULI AB Analytical models have been developed in recent years for predicting the elastic properties of fiber reinforced composite laminates with undulated laminas, such as woven and filament wound composites. In these models, a representative volume element (RVE) is defined, assumptions about how strains or stresses vary throughout the RVE are made, and then the homogenized constitutive behavior of the RVE is calculated. The constitutive behavior has been modeled in the context of either two-dimensional plate behavior or three-dimensional continuum behavior. Of the latter genre, the few existing models capable of handling undulated laminas have not captured the full three-dimensional constitutive behavior, including all the out-of-plane couplings arising from the most general undulation configurations. Building on the existing models, the current investigation utilizes micromechanics to determine the three-dimensional stiffness at discrete stations along the length of an RVE containing an undulated lamina, and determines the overall RVE constitutive behavior by averaging either the stiffness or compliance along the length of the RVE, thus providing bounds on the material behavior. The new model is evaluated by comparison with existing models as well as experiments for laminates with and without undulations. Similarities and differences with previous models are discussed. C1 [Henry, Todd C.; Riddick, Jaret C.] US Army, Res Lab, Vehicle Technol Directorate, Adelphi, MD USA. [Bakis, Charles E.] Penn State Univ, Dept Engn Sci & Mech, University Pk, PA 16802 USA. RP Henry, TC (reprint author), Army Res Lab, 4603 Flare Loop, Aberdeen, MD 21005 USA. EM todd.c.henry2.civ@mail.mil NR 28 TC 1 Z9 1 U1 2 U2 7 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0731-6844 EI 1530-7964 J9 J REINF PLAST COMP JI J. Reinf. Plast. Compos. PD JAN PY 2016 VL 35 IS 2 BP 151 EP 164 DI 10.1177/0731684415609429 PG 14 WC Materials Science, Composites; Polymer Science SC Materials Science; Polymer Science GA CZ9XW UT WOS:000367452200005 ER PT J AU Slaughter, AJ Koehly, LM AF Slaughter, Andrew J. Koehly, Laura M. TI Multilevel models for social networks: Hierarchical Bayesian approaches to exponential random graph modeling SO SOCIAL NETWORKS LA English DT Article DE Multilevel networks; Hierarchical models; Exponential random graph models; Autoregressive models ID LOGISTIC-REGRESSION; UNCERTAINTY; SAMPLER AB In many applications, researchers may be interested in studying patterns of dyadic relationships that involve multiple groups, with a focus on modeling the systematic patterns within groups and how these structural patterns differ across groups. A number of different models - many of them potentially quite powerful - have been developed that allow for researchers to study these differences. However, as with any set of models, these are limited in ways that constrain the types of questions researchers may ask, such as those involving the variance in group-wise structural features. In this paper, we demonstrate some of the ways in which multilevel models based on a hierarchical Bayesian approach might be used to further develop and extend existing exponential random graph models to address such constraints. These include random coefficient extensions to the standard ERGM for sets of multiple unconnected or connected networks and examples of multilevel models that allow for the estimation of structural entrainment among connected groups. We demonstrate the application of these models to real-world and simulated data sets. Published by Elsevier B.V. C1 [Slaughter, Andrew J.] US Army Res Inst Behav & Social Sci, Arlington, VA 22202 USA. [Koehly, Laura M.] NHGRI, Bethesda, MD USA. RP Slaughter, AJ (reprint author), US Army Res Inst Behav & Social Sci, Arlington, VA 22202 USA. EM andrew.j.slaughter.civ@mail.mil; koehlyl@mail.nih.gov FU Breast Cancer Research Program, The University of Texas M.D. Anderson Cancer Center; Intramural Research Program of the National Human Genome Research Institute at the National Institutes of Health [ZIA HG200335]; US Army Research Institute for the Behavioral and Social Sciences FX The Circle of Friends study, which provided exemplar data, was supported by the Breast Cancer Research Program, The University of Texas M.D. Anderson Cancer Center. We would like to thank Karen Basen-Engquist for her assistance in obtaining the Circle of Friends data. The completion of this manuscript was supported by the Intramural Research Program of the National Human Genome Research Institute at the National Institutes of Health (ZIA HG200335 to Laura M. Koehly) and the US Army Research Institute for the Behavioral and Social Sciences. The views, opinions, and/or findings contained in this article are solely those of the authors and should not be construed as an official Department of the Army or DOD position, policy, or decision, unless so designated by other documentation. NR 42 TC 0 Z9 1 U1 2 U2 14 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-8733 EI 1879-2111 J9 SOC NETWORKS JI Soc. Networks PD JAN PY 2016 VL 44 BP 334 EP 345 DI 10.1016/j.socnet.2015.11.002 PG 12 WC Anthropology; Sociology SC Anthropology; Sociology GA CZ9NI UT WOS:000367423900030 ER PT J AU Hourigan, LA Omaye, ST Keen, CL Jones, JA Dubick, MA AF Hourigan, Leslie A. Omaye, Stanley T. Keen, Carl L. Jones, John A. Dubick, Michael A. TI Vitamin and Trace Element Loss from Negative-Pressure Wound Therapy SO ADVANCES IN SKIN & WOUND CARE LA English DT Article DE wound exudate; micronutrients; vitamins; minerals; negative pressure wound therapy ID RETINOL-BINDING-PROTEIN; CRITICALLY-ILL; SURROGATE MEASURE; SUPPLEMENTATION; NUTRITION; TRAUMA; COPPER AB OBJECTIVE: This study investigated select vitamin and trace element loss from wound exudates in burn and trauma patients treated with negative-pressure wound therapy (NPWT). DESIGN: A prospective observational study was performed using wound exudate samples. SETTING: A level I trauma center acute care hospital. PARTICIPANTS: The study was composed of 8 patients with open abdomens and 9 patients with 12 soft-tissue wounds. MAIN OUTCOME MEASURES: The goal was to collect wound exudate samples daily for 3 days, then every other day to day 9 or until NPWT was discontinued, and to analyze for vitamins A (retinol), C, and E and zinc (Zn), iron (Fe), and copper (Cu). Daily loss of each micronutrient was calculated from their concentration and 24-hour volumes of the exudates. MAIN RESULTS: Exudate loss in the open-abdomen group was significantly higher than in the patients with soft-tissue wounds (900 547 vs 359 +/- 246 mL/d). The mean 24-hour loss of vitamins A, C, and E were 0.3, 2.8, and 11 mg, respectively, in the open-abdomen group. Over the same period, the losses of Zn, Fe, and Cu were 0.5, 0.4, and 0.25 mg, respectively, in these patients. Micronutrient 24-hour loss was significantly lower in the soft-tissue wound patients than in the open-abdomen group. CONCLUSIONS: The data support the concept that significant amounts of micronutrients can be lost from NPWT wound exudates, particularly in open abdomens. These losses should be considered in the nutritional support of these patients who typically are in a hypermetabolic and catabolic state. C1 [Hourigan, Leslie A.] Brooke Army Med Ctr, San Antonio, TX 78234 USA. [Omaye, Stanley T.] Univ Nevada, Dept Agr Nutr & Vet Sci, Reno, NV 89557 USA. [Keen, Carl L.] Univ Calif Davis, Nutr & Internal Med, Davis, CA 95616 USA. [Jones, John A.] US Army Inst Surg Res, San Antonio, TX USA. [Dubick, Michael A.] US Army Inst Surg Res, DCR Res Program, San Antonio, TX USA. RP Hourigan, LA (reprint author), Brooke Army Med Ctr, San Antonio, TX 78234 USA. NR 32 TC 1 Z9 1 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1527-7941 EI 1538-8654 J9 ADV SKIN WOUND CARE JI Adv. Skin Wound Care PD JAN PY 2016 VL 29 IS 1 BP 20 EP 25 DI 10.1097/01.ASW.0000473680.06666.6a PG 6 WC Dermatology; Nursing; Surgery SC Dermatology; Nursing; Surgery GA CZ2LP UT WOS:000366937000004 ER PT J AU Lloyd, JR Jayasekara, PS Jacobson, KA AF Lloyd, John R. Jayasekara, P. Suresh Jacobson, Kenneth A. TI Characterization of polyamidoamino (PAMAM) dendrimers using in-line reversed phase LC electrospray ionization mass spectrometry SO ANALYTICAL METHODS LA English DT Article ID POLY(AMIDOAMINE) DENDRIMERS; COMPLEXES; SILICA AB Generation 3 (G3) PAMAM dendrimers are symmetrical, highly branched polymers widely reported in the scientific literature as therapeutic agents themselves or as carrier scaffolds for various therapeutic agents. A large number of analytical techniques have been applied to study PAMAM dendrimers, but one that has been missing is in-line reversed phase LC electrospray ionization mass spectrometry (RP/LC/ESI/MS). To translate PAMAM dendrimers into therapeutic agents, a better understanding of their purity, stability and structure is required, and in-line RP/LC/ESI/MS is widely applied to all three of these analytical questions. In this study, we developed a robust in-line RP/LC/ESI/MS method for assessing stability, purity and structure of the G3 PAMAM dendrimers, and we also examined the reasons why previous attempts at method development failed. Using the RP/LC/ESI/MS method we uncovered several unique aspects of the chemistry of G3 PAMAM dendrimers. They are interconverted between two isomeric forms by dialysis, and under higher concentration levels there is an inter-molecular displacement reaction resulting, which degrades PAMAM dendrimers. Purification of G3 dendrimers by RP/LC was also previously unreported; so we slightly modified the LC/MS method for isolating individual components from a complex dendrimer mixture. Thus, we have developed a robust, comprehensive method for characterizing PAMAM dendrimers and their degradation. C1 [Lloyd, John R.; Jayasekara, P. Suresh; Jacobson, Kenneth A.] NIDDK, Bioorgan Chem Lab, NIH, Bethesda, MD 20892 USA. [Jayasekara, P. Suresh] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. RP Jacobson, KA (reprint author), NIDDK, Bioorgan Chem Lab, NIH, Bethesda, MD 20892 USA. EM kajacobs@helix.nih.gov RI Jacobson, Kenneth/A-1530-2009 OI Jacobson, Kenneth/0000-0001-8104-1493 FU Intramural Research Program of the NIH, NIDDK FX We thank the Intramural Research Program of the NIH, NIDDK for support. NR 32 TC 1 Z9 1 U1 1 U2 15 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1759-9660 EI 1759-9679 J9 ANAL METHODS-UK JI Anal. Methods PY 2016 VL 8 IS 2 BP 263 EP 269 DI 10.1039/c5ay01995h PG 7 WC Chemistry, Analytical; Food Science & Technology; Spectroscopy SC Chemistry; Food Science & Technology; Spectroscopy GA CZ6XF UT WOS:000367243600005 PM 26997980 ER PT J AU George, J AF George, Jemin TI A robust estimator for stochastic systems under unknown persistent excitation SO AUTOMATICA LA English DT Article DE Robust estimator; Unknown input observer; Kalman filter; Unbiased minimum-variance filter; Stochastic systems ID RECURSIVE STATE ESTIMATION; LINEAR-SYSTEMS; UNCERTAIN SYSTEMS; INPUTS; OBSERVERS; CONSTRAINT; DESIGN; FILTER AB A robust estimator for uncertain stochastic systems under unknown persistent disturbance is presented. The given discrete-time stochastic formulation neither requires a known bound on the magnitude of the unknown excitation nor assumes stability of the system. However, the proposed estimator assumes certain structural conditions on system uncertainties. Though the proposed estimator is developed based on stochastic Lyapunov analysis, its structure and performance are comparable to that of unbiased minimum-variance filters based on the disturbance decoupling technique. Unlike unbiased minimum-variance filters, implementation of the developed estimator only requires adding an auxiliary term to the nominal steady-state Kalman filter, and it does not involve any similarity transformation or propagation of matrix difference equations. Published by Elsevier Ltd. C1 [George, Jemin] US Army Res Lab, Adelphi, MD 20783 USA. RP George, J (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM jemin.george.civ@mail.mil NR 24 TC 2 Z9 2 U1 2 U2 9 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0005-1098 EI 1873-2836 J9 AUTOMATICA JI Automatica PD JAN PY 2016 VL 63 BP 156 EP 161 DI 10.1016/j.automatica.2015.10.006 PG 6 WC Automation & Control Systems; Engineering, Electrical & Electronic SC Automation & Control Systems; Engineering GA CZ5CF UT WOS:000367119300019 ER PT J AU Minnicino, MA Santare, MH AF Minnicino, Michael A. Santare, Michael H. TI Predicting microdroplet force response using a multiscale modeling approach SO COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING LA English DT Article DE Finite element analysis (FEA); Damage mechanics; Interface/interphase; Micro-mechanics ID FIBER-MATRIX INTERPHASE; MICROBOND TEST; FIBER/MATRIX INTERFACE; POLYMER COMPOSITES; COLLOIDAL SILICA; SHEAR-STRENGTH; BOND STRENGTH; GLASS-FIBERS; PULL-OUT; TESTS AB An axisymmetric microscale finite element model of a microdroplet test specimen is developed where the structural response of the fiber-droplet interface is accounted for by surface-based cohesive behavior. In this study, the interface cohesive response is estimated using a nanoscale interface finite element model that explicitly includes the effects of fiber surface topography and the interphase region. The interphase behavior in the nanoscale interface model is calibrated using indirect experimental data. Once calibrated, the fiber surface topography in the nanoscale interface model is modified in order to estimate the parameters defining the surface-based cohesive behavior of similar fiber-matrix systems with different fiber topography. The effect of altering the fiber topography on the force response of the microdroplet test can then be predicted by the microdroplet FE model. Comparing the simulation results with experimental data from the literature shows that this multiscale modeling approach gives accurate predictions for the interfacial shear stress. Published by Elsevier Ltd. C1 [Minnicino, Michael A.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Minnicino, Michael A.; Santare, Michael H.] Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA. [Minnicino, Michael A.; Santare, Michael H.] Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. RP Minnicino, MA (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM michael.a.minnicino.civ@mail.mil NR 39 TC 0 Z9 0 U1 7 U2 16 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1359-835X EI 1878-5840 J9 COMPOS PART A-APPL S JI Compos. Pt. A-Appl. Sci. Manuf. PD JAN PY 2016 VL 80 BP 39 EP 52 DI 10.1016/j.compositesa.2015.10.005 PG 14 WC Engineering, Manufacturing; Materials Science, Composites SC Engineering; Materials Science GA CZ5FB UT WOS:000367126800005 ER PT J AU Zizzi, S Kadushin, P Michel, J Abildso, C AF Zizzi, Sam Kadushin, Peter Michel, Jesse Abildso, Christiaan TI Client Experiences With Dietary, Exercise, and Behavioral Services in a Community-Based Weight Management Program SO HEALTH PROMOTION PRACTICE LA English DT Article DE weight loss; weight management; nutrition; physical activity; behavioral therapy ID PHYSICAL-ACTIVITY; RANDOMIZED-TRIAL; OBESITY; INTERVENTIONS; MAINTENANCE; PREVENTION; SETTINGS; SCIENCE AB Compared with randomized trials, community-based interventions are delivered by a wider variety of professionals with varied training backgrounds. When evidence-based programs are scaled into larger formats and disseminated to a wider audience, little is understood about how clients experience these interventions. To understand the experience of clients after meetings with nutrition, exercise, and health behavior professionals, researchers surveyed participants after 6 months in a weight management program. A total of 958 participants were recruited in monthly cohorts beginning September 2011 to complete a program evaluation survey. Qualitative inductive analysis was completed on several open-text items querying respondents as to what they found helpful from meetings with a registered dietitian, personal trainer, and health behavior counselor. Results indicate participants benefitted from gaining knowledge, learning new behavioral skills, or from interpersonal interactions. Findings suggest that the various professional services are valued by clients and that professionals appear to stay within their scope of practice. Implications for those working in weight management are discussed. C1 [Zizzi, Sam] W Virginia Univ, Coll Phys Act & Sport Sci, Morgantown, WV 26506 USA. [Kadushin, Peter] Western State Colorado Univ, Gunnison, CO USA. [Michel, Jesse] US Army, Comprehens Soldier & Family Fitness Program, Honolulu, HI USA. [Abildso, Christiaan] W Virginia Univ, Sch Publ Hlth, Morgantown, WV 26506 USA. RP Zizzi, S (reprint author), W Virginia Univ, Dept Sport Sci, Morgantown, WV 26506 USA. EM szizzi@mail.wvu.edu NR 29 TC 0 Z9 0 U1 1 U2 6 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1524-8399 EI 1552-6372 J9 HEALTH PROMOT PRACT JI Health Promot. Pract. PD JAN PY 2016 VL 17 IS 1 BP 98 EP 106 DI 10.1177/1524839915610316 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CZ7WG UT WOS:000367310500012 PM 26482344 ER PT J AU Baron, A Lindsey, K Sidow, SJ Dickinson, D Chuang, A McPherson, JC AF Baron, Aleksandr Lindsey, Kimberly Sidow, Stephanie J. Dickinson, Douglas Chuang, Augustine McPherson, James C. TI Effect of a Benzalkonium Chloride Surfactant-Sodium Hypochlorite Combination on Elimination of Enterococcus faecalis SO JOURNAL OF ENDODONTICS LA English DT Article DE Benzalkonium chloride; biofilm; dentin tubules; Enterococcus faecalis ID ROOT CANALS; DISINFECTING SOLUTIONS; APICAL PERIODONTITIS; ENDODONTIC TREATMENT; IN-VITRO; BIOFILM; DENTIN; PENETRATION; DISSOLUTION; IRRIGANTS AB Introduction: The purpose of this investigation was to determine the effect of a sodium hypochlorite surfactant combination on the removal of Enterococcus faecalis from infected teeth. Methods: Sixty-four extracted human single canal anterior teeth were prepared with rotary instrumentation and sterilized. Teeth were divided into 4 groups, N = 16. Three experimental groups were inoculated with E. faecalis and cultured for 21 days before use: positive control group, no irrigation; NaOCl group, irrigated with 5 mL 6% NaOCl; and NaOCl/BAK group, irrigated with 5 mL 6% NaOCl/0.008% benzalkonium chloride (BAK). The negative control group received medium only and no inoculate. Paper point sampling of the canals was obtained before irrigation (Si) for all 4 groups and for 2 groups after irrigation (52) to determine remaining colony-forming units. After sampling, all teeth were split in half and evaluated for bacterial viability colony-forming units and penetration of dentinal tubules by using fluorescent vital dye staining and confocal laser scanning microscopy. Results: Comparison of pre-irrigation and post-irrigation paper point samples from the 2 irrigated groups showed a significant reduction in bacterial canal load (P < .001, Kruskal-Wallis), with a significantly lower load in the NaOCl/BAK group than in the NaOCl group (P = .001, Mann-Whitney U test); 68.8% of the NaOCl/BAK samples gave no recoverable counts. In contrast, no significant difference between these groups was found for counts recovered from dentin. Confocal laser scanning microscopy showed no differences in tubule penetration. Conclusions: The addition of BAK to NaOCl significantly reduced the number of remaining bacteria within the canal after irrigation compared with NaOCl alone. C1 [Baron, Aleksandr; Lindsey, Kimberly; Sidow, Stephanie J.; Dickinson, Douglas] US Army, Dent Activ, Ft Gordon, GA 30905 USA. [Chuang, Augustine; McPherson, James C.] Dwight D Eisenhower Army Med Ctr, Dept Clin Invest, Ft Gordon, GA USA. RP Lindsey, K (reprint author), US Army, Dent Activ, Dept Endodont, Ft Gordon, GA 30905 USA. EM kimberly.w.lindsey.mil@mail.mil NR 36 TC 0 Z9 0 U1 1 U2 6 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0099-2399 EI 1878-3554 J9 J ENDODONT JI J. Endod. PD JAN PY 2016 VL 42 IS 1 BP 145 EP 149 DI 10.1016/j.joen.2015.08.035 PG 5 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA CZ5BM UT WOS:000367117100025 PM 26577873 ER PT J AU Cuddy, MF Poda, AR Moser, RD Weiss, CA Cairns, C Steevens, JA AF Cuddy, Michael F. Poda, Aimee R. Moser, Robert D. Weiss, Charles A. Cairns, Carolyn Steevens, Jeffery A. TI A weight-of-evidence approach to identify nanomaterials in consumer products: a case study of nanoparticles in commercial sunscreens SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY LA English DT Article DE FFF; nanoparticles; sunscreen; TiO2; Weight-of-evidence; ZnO ID SILVER NANOPARTICLES; TIO2; FOOD; TOXICITY AB Nanoscale ingredients in commercial products represent a point of emerging environmental concern due to recent findings that correlate toxicity with small particle size. A weight-of-evidence (WOE) approach based upon multiple lines of evidence (LOE) is developed here to assess nanomaterials as they exist in consumer product formulations, providing a qualitative assessment regarding the presence of nanomaterials, along with a baseline estimate of nanoparticle concentration if nanomaterials do exist. Electron microscopy, analytical separations, and X-ray detection methods were used to identify and characterize nanomaterials in sunscreen formulations. The WOE/LOE approach as applied to four commercial sunscreen products indicated that all four contained at least 10% dispersed primary particles having at least one dimension < 100 nm in size. Analytical analyses confirmed that these constituents were comprised of zinc oxide (ZnO) or titanium dioxide (TiO2). The screening approaches developed herein offer a streamlined, facile means to identify potentially hazardous nanomaterial constituents with minimal abrasive processing of the raw material. C1 [Cuddy, Michael F.; Poda, Aimee R.; Steevens, Jeffery A.] US Army, Corps Engineers, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Moser, Robert D.; Weiss, Charles A.] US Army, Corps Engineers, Engineer Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA. RP Cuddy, MF (reprint author), Northwest Coll, Dept Chem, 231 W 6th St Powell, Powell, WY 82435 USA. EM michael.cuddy@nwc.edu RI Poda, Aimee/K-1905-2012 NR 18 TC 1 Z9 1 U1 6 U2 27 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1559-0631 EI 1559-064X J9 J EXPO SCI ENV EPID JI J. Expo. Sci. Environ. Epidemiol. PD JAN-FEB PY 2016 VL 26 IS 1 BP 26 EP 34 DI 10.1038/jes.2015.51 PG 9 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA CZ5PY UT WOS:000367155700004 PM 26374657 ER PT J AU Mizukami, N Clark, MP Gutmann, ED Mendoza, PA Newman, AJ Nijssen, B Ben Livneh, Hay, LE Arnold, JR Brekke, LD AF Mizukami, Naoki Clark, Martyn P. Gutmann, Ethan D. Mendoza, Pablo A. Newman, Andrew J. Nijssen, Bart Ben Livneh Hay, Lauren E. Arnold, Jeffrey R. Brekke, Levi D. TI Implications of the Methodological Choices for Hydrologic Portrayals of Climate Change over the Contiguous United States: Statistically Downscaled Forcing Data and Hydrologic Models SO JOURNAL OF HYDROMETEOROLOGY LA English DT Article ID DAILY SOLAR-RADIATION; COLORADO RIVER-BASIN; SIERRA-NEVADA; LAND-SURFACE; WATER-RESOURCES; CHANGE IMPACTS; TEMPERATURE; CALIFORNIA; SCALE; PRECIPITATION AB Continental-domain assessments of climate change impacts on water resources typically rely on statistically downscaled climate model outputs to force hydrologic models at a finer spatial resolution. This study examines the effects of four statistical downscaling methods [bias-corrected constructed analog (BCCA), bias-corrected spatial disaggregation applied at daily (BCSDd) and monthly scales (BCSDm), and asynchronous regression (AR)] on retrospective hydrologic simulations using three hydrologic models with their default parameters (the Community Land Model, version 4.0; the Variable Infiltration Capacity model, version 4.1.2; and the Precipitation-Runoff Modeling System, version 3.0.4) over the contiguous United States (CONUS). Biases of hydrologic simulations forced by statistically downscaled climate data relative to the simulation with observation-based gridded data are presented. Each statistical downscaling method produces different meteorological portrayals including precipitation amount, wet-day frequency, and the energy input (i.e., shortwave radiation), and their interplay affects estimations of precipitation partitioning between evapotranspiration and runoff, extreme runoff, and hydrologic states (i.e., snow and soil moisture). The analyses show that BCCA underestimates annual precipitation by as much as -250 mm, leading to unreasonable hydrologic portrayals over the CONUS for all models. Although the other three statistical downscaling methods produce a comparable precipitation bias ranging from -10 to 8 mm across the CONUS, BCSDd severely overestimates the wet-day fraction by up to 0.25, leading to different precipitation partitioning compared to the simulations with other downscaled data. Overall, the choice of downscaling method contributes to less spread in runoff estimates (by a factor of 1.5-3) than the choice of hydrologic model with use of the default parameters if BCCA is excluded. C1 [Mizukami, Naoki; Clark, Martyn P.; Gutmann, Ethan D.; Mendoza, Pablo A.; Newman, Andrew J.] Natl Ctr Atmospher Res, Boulder, CO 80307 USA. [Nijssen, Bart] Univ Washington, Seattle, WA 98195 USA. [Ben Livneh] Univ Colorado, Cooperat Inst Res Environm Sci, Boulder, CO 80309 USA. [Hay, Lauren E.] US Geol Survey, Denver, CO 80225 USA. [Arnold, Jeffrey R.] US Army Corps Engineers, Seattle, WA USA. [Brekke, Levi D.] US Bur Reclamat, Denver, CO 80225 USA. [Ben Livneh] Univ Colorado, Dept Civil Environm & Architectural Engn, Boulder, CO 80309 USA. RP Mizukami, N (reprint author), NCAR, POB 3000, Boulder, CO 80307 USA. EM mizukami@ucar.edu RI Mizukami, Naoki/J-7027-2015; Gutmann, Ethan/I-5728-2012; Nijssen, Bart/B-1013-2012; OI Gutmann, Ethan/0000-0003-4077-3430; Nijssen, Bart/0000-0002-4062-0322; LIVNEH, BEN/0000-0001-5445-2473 FU U.S Bureau of Reclamation; U.S Army Corps of Engineers FX This work was financially supported by the U.S Bureau of Reclamation and the U.S Army Corps of Engineers. The authors thank Steven Markstrom, Steve Regan, and Roland Viger of the USGS for providing PRMS parameters and Youlong Xia and Justin Sheffield for providing VIC parameters. Finally, the authors are grateful to Stacey Archfield and three anonymous reviewers for their constructive comments. NR 99 TC 8 Z9 8 U1 7 U2 12 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 1525-755X EI 1525-7541 J9 J HYDROMETEOROL JI J. Hydrometeorol. PD JAN PY 2016 VL 17 IS 1 BP 73 EP 98 DI 10.1175/JHM-D-14-0187.1 PG 26 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA CZ9FH UT WOS:000367402700003 ER PT J AU Park, AM Wycisk, RJ Ren, XM Turley, FE Pintauro, PN AF Park, Andrew M. Wycisk, Ryszard J. Ren, Xiaoming Turley, Forbes E. Pintauro, Peter N. TI Crosslinked poly(phenylene oxide)-based nanofiber composite membranes for alkaline fuel cells SO JOURNAL OF MATERIALS CHEMISTRY A LA English DT Article ID ANION-EXCHANGE MEMBRANES; CONDUCTING MEMBRANES; NMR-SPECTROSCOPY; STABILITY; DEGRADATION; PERFORMANCE; HYDROXIDE; TRANSPORT; POLYMER; COPOLYMER AB Anion exchange membranes were fabricated from diamine-crosslinked poly(phenylene oxide) polyelectrolyte nanofibers that were functionalized with either benzyl trimethylammonium or 1,2-dimethylimidazolium groups and embedded in a reinforcing matrix of polyphenylsulfone (PPSU). Nanofibers of the polyelectrolyte precursor, brominated poly(phenylene oxide) with 0.95 CH2Br groups per mer, and PPSU were simultaneously electrospun onto a common collector and the resulting dual fiber mat was converted into a dense and defect-free anion exchange membrane by sequential soaking in a diamine crosslinker solution, exposure to chloroform vapor, and immersion in a solution of either trimethylamine or 1,2-dimethylimidazole. The degree of crosslinking and the ratio of uncharged PPSU to functionalized poly(phenylene oxide) polyelectrolyte were varied to yield composite membranes with an effective ion exchange capacity (IEC) ranging from 1.2-2.8 mmol g(-1). A membrane with benzyl trimethylammonium-functionalized polyelectrolyte fibers (4.0 mmol g(-1) IEC) with 15% crosslinks and 50 wt% uncharged PPSU exhibited a high hydroxide ion conductivity in water at 23 degrees C (66 mS cm(-1)), reasonable water swelling (96%), robust mechanical properties (15 MPa stress-at-break in the hydrated state), and good chemical stability in 1.0 M KOH at 60 degrees C. Initial hydrogen/oxygen fuel cell tests with this membrane (40 mm thick) were promising, with a peak power density of 320 mW cm(-2). C1 [Park, Andrew M.; Wycisk, Ryszard J.; Turley, Forbes E.; Pintauro, Peter N.] Vanderbilt Univ, Dept Chem & Biomol Engn, Nashville, TN 37235 USA. [Ren, Xiaoming] US Army, Res Lab, RDRL SED C, Adelphi, MD 20783 USA. RP Pintauro, PN (reprint author), Vanderbilt Univ, Dept Chem & Biomol Engn, 221 Kirkland Hall, Nashville, TN 37235 USA. EM peter.pintauro@vanderbilt.edu FU Army Research Office [W911NF-11-1-0454]; National Science Foundation [CBET-1032948] FX The authors thank the Army Research Office, (Contract No. W911NF-11-1-0454) and the National Science Foundation (Grant CBET-1032948) for their financial support of this research. NR 41 TC 6 Z9 6 U1 9 U2 52 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2050-7488 EI 2050-7496 J9 J MATER CHEM A JI J. Mater. Chem. A PY 2016 VL 4 IS 1 BP 132 EP 141 DI 10.1039/c5ta06209h PG 10 WC Chemistry, Physical; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Energy & Fuels; Materials Science GA CZ0VX UT WOS:000366825300012 ER PT J AU Loers, G Saini, V Mishra, B Gul, S Chaudhury, S Wallqvist, A Kaur, G Schachner, M AF Loers, Gabriele Saini, Vedangana Mishra, Bibhudatta Gul, Sheraz Chaudhury, Sidhartha Wallqvist, Anders Kaur, Gurcharan Schachner, Melitta TI Vinorelbine and epirubicin share common features with polysialic acid and modulate neuronal and glial functions SO JOURNAL OF NEUROCHEMISTRY LA English DT Article DE epirubicin; migration; neural cell adhesion molecule; neurite outgrowth; polysialic acid; vinorelbine ID CELL-ADHESION MOLECULE; PSYCHIATRIC-DISORDER PATIENTS; TEMPORAL-LOBE EPILEPSY; SPINAL-CORD-INJURY; PSA-NCAM; NERVOUS-SYSTEM; SCHWANN-CELLS; NEURITE OUTGROWTH; SYNAPTIC PROTEINS; EXPRESSION AB Polysialic acid (PSA), a large, linear glycan composed of 8 to over 100 2,8-linked sialic acid residues, modulates development of the nervous system by enhancing cell migration, axon pathfinding, and synaptic targeting and by regulating differentiation of progenitor cells. PSA also functions in developing and adult immune systems and is a signature of many cancers. In this study we identified vinorelbine, a semi-synthetic third generation vinca alkaloid, and epirubicin, an anthracycline and 4-epimer of doxorubicin, as PSA mimetics. Similar to PSA, vinorelbine and epirubicin bind to the PSA-specific monoclonal antibody 735 and compete with the bacterial analog of PSA, colominic acid in binding to monoclonal antibody 735. Vinorelbine and epirubicin stimulate neurite outgrowth of cerebellar neurons via the neural cell adhesion molecule, via myristoylated alanine-rich C kinase substrate, and via fibroblast growth factor receptor, signaling through Erk pathways. Furthermore, the two compounds enhance process formation of Schwann cells and migration of cerebellar neurons in culture, and reduce migration of astrocytes after injury. These novel results show that the structure and function of PSA can be mimicked by the small organic compounds vinorelbine and epirubicin, thus raising the possibility to re-target drugs used in treatment of cancers to nervous system repair. C1 [Loers, Gabriele; Mishra, Bibhudatta; Schachner, Melitta] Univ Klinikum Hamburg Eppendorf, Zentrum Mol Neurobiol Hamburg, Hamburg, Germany. [Saini, Vedangana; Kaur, Gurcharan] Guru Nanak Dev Univ, Dept Biotechnol, Amritsar, Punjab, India. [Gul, Sheraz] Fraunhofer Inst Mol Biol & Appl Ecol Screening Po, Hamburg, Germany. [Chaudhury, Sidhartha; Wallqvist, Anders] US Army, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, DoD Biotechnol High Performance Comp Software App, Ft Detrick, MD USA. [Schachner, Melitta] Rutgers State Univ, Keck Ctr Collaborat Neurosci, Piscataway, NJ USA. [Schachner, Melitta] Rutgers State Univ, Dept Cell Biol & Neurosci, Piscataway, NJ USA. [Schachner, Melitta] Shantou Univ, Coll Med, Ctr Neurosci, Shantou, Guangdong, Peoples R China. RP Schachner, M (reprint author), Univ Klinikum Hamburg Eppendorf, Zentrum Mol Neurobiol Hamburg, Inst Biosynth Neuraler Strukt, Hamburg, Germany. EM kgurcharan.neuro@yahoo.com; melitta.schachner@zmnh.uni-hamburg.de OI wallqvist, anders/0000-0002-9775-7469; Saini, Vedangana/0000-0002-9944-0262 FU Council of Scientific and Industrial Research (CSIR) India; DAAD, Germany; NIH [RO1 NS078385-01A1]; Bundesministerium fur Bildung und Forschung (BMBF); Indian Council of Medical Research (ICMR) (Indo-German Research Project) [10/050]; U.S. Army Medical Research and Materiel Command Clinical and Rehabilitative Medicine Research Program FX The authors are grateful to Dr Rita Gerardy-Schahn for donation of the antibody 735 and EndoN, Markus Wolf and Ute Bork for excellent technical assistance, Eva Kronberg for excellent animal care, and Philip Gribbon for help with the screening setup. Vedangana Saini thanks the Council of Scientific and Industrial Research (CSIR) India for a Senior Research Fellowship and the DAAD for a 6-month research scholarship in Germany. Infrastructure provided by University Grants Commission (UGC), India, under the UPE and CPEPA schemes and Department of Biotechnology (DBT), India, under the DISC facility is highly acknowledged. Melitta Schachner thanks the NIH for support. This work was supported by the Bundesministerium fur Bildung und Forschung (BMBF) and Indian Council of Medical Research (ICMR) (Indo-German Research Project 10/050 to Melitta Schachner and Gurcharan Kaur), the U.S. Army Medical Research and Materiel Command Clinical and Rehabilitative Medicine Research Program (to Anders Wallqvist and Sidhartha Chaudhury), and the NIH grant RO1 NS078385-01A1 (to Melitta Schachner). The authors declare that no competing interests exist. The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U.S. Army or the U.S. Department of Defense. This paper has been approved for public release with unlimited distribution. NR 74 TC 1 Z9 1 U1 1 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0022-3042 EI 1471-4159 J9 J NEUROCHEM JI J. Neurochem. PD JAN PY 2016 VL 136 IS 1 BP 48 EP 62 DI 10.1111/jnc.13383 PG 15 WC Biochemistry & Molecular Biology; Neurosciences SC Biochemistry & Molecular Biology; Neurosciences & Neurology GA CZ6DZ UT WOS:000367192700005 PM 26443186 ER PT J AU Littlefield, PD Pinto, RL Burrows, HL Brungart, DS AF Littlefield, Philip D. Pinto, Robin L. Burrows, Holly L. Brungart, Douglas S. TI The Vestibular Effects of Repeated Low-Level Blasts SO JOURNAL OF NEUROTRAUMA LA English DT Article DE military injury; peripheral nerve injury; traumatic brain injury ID TRAUMATIC BRAIN-INJURY; POSITION UPBEAT NYSTAGMUS; NORMATIVE DATA; EXPOSURE; ENCEPHALOPATHY; PREGABALIN; VERTIGO; IRAQ AB The objective of this study was to use a prospective cohort of United States Marine Corps (USMC) instructors to identify any acute or long-term vestibular dysfunction following repeated blast exposures during explosive breaching training. They were assessed in clinic and on location during training at the USMC Methods of Entry School, Quantico, VA. Subjects received comprehensive baseline vestibular assessments and these were repeated in order to identify longitudinal changes. They also received shorter assessments immediately following blast exposure in order to identify acute findings. The main outcome measures were the Neurobehavioral Symptom Inventory, vestibular Visual Analog Scale (VAS) of subjective vestibular function, videonystagmography (VNG), vestibular evoked myogenic potentials (VEMP), rotary chair (including the unilateral centrifugation test), computerized dynamic posturography, and computerized dynamic visual acuity. A total of 11 breachers and 4 engineers were followed for up to 17 months. No acute effects or longitudinal deteriorations were identified, but there were some interesting baseline group differences. Upbeat positional nystagmus was common, and correlated (p<0.005) with a history of mild traumatic brain injury (mTBI). Several instructors had abnormally short low-frequency phase leads on rotary chair testing. This study evaluated breaching instructors over a longer test period than any other study, and the results suggest that this population appears to be safe from a vestibular standpoint at the current exposure levels. Upbeat positional nystagmus correlated with a history of mTBI in this population, and this has not been described elsewhere. The data trends also suggest that this nystagmus could be an acute blast effect. However, the reasons for the abnormally short phase leads seen in rotary chair testing are unclear at this time. Further investigation seems warranted. C1 [Littlefield, Philip D.] Walter Reed Natl Mil Med Ctr, Dept Otolaryngol, Bethesda, MD USA. [Pinto, Robin L.; Burrows, Holly L.; Brungart, Douglas S.] Walter Reed Natl Mil Med Ctr, Audiol & Speech Pathol Ctr, Bethesda, MD USA. RP Littlefield, PD (reprint author), Tripler Army Med Ctr, Dept Otolaryngol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM philip.d.littlefield.mil@mail.mil FU U.S. Army Medical Research and Materiel Command, Intramural War Supplemental Program [W81XWH-09-2-0192]; Congressionally Directed Medical Research Program Intramural Traumatic Brain Injury Investigator-Initiated Research Award (Ahroon) [FY07] FX No competing financial interests exist. This research was performed in collaboration with the U.S. Army Aeromedical Research Lab, Fort Rucker, AL. William A. Ahroon, PhD, was the principal investigator of the overall grant supporting it. The grant was through the U.S. Army Medical Research and Materiel Command, Intramural War Supplemental Program, Award Number W81XWH-09-2-0192. This was from the Congressionally Directed Medical Research Program FY07 Intramural Traumatic Brain Injury Investigator-Initiated Research Award (Ahroon). The funding period was September 29, 2009 to May 28, 2014. NR 37 TC 0 Z9 0 U1 3 U2 5 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JAN 1 PY 2016 VL 33 IS 1 BP 71 EP 81 DI 10.1089/neu.2014.3824 PG 11 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA CZ4EW UT WOS:000367057200009 PM 25790248 ER PT J AU Boutte, AM Deng-Bryant, Y Johnson, D Tortella, FC Dave, JR Shear, DA Schmid, KE AF Boutte, Angela M. Deng-Bryant, Ying Johnson, David Tortella, Frank C. Dave, Jitendra R. Shear, Deborah A. Schmid, Kara E. TI Serum Glial Fibrillary Acidic Protein Predicts Tissue Glial Fibrillary Acidic Protein Break-Down Products and Therapeutic Efficacy after Penetrating Ballistic-Like Brain Injury SO JOURNAL OF NEUROTRAUMA LA English DT Article DE biomarker; CsA; GFAP-BDP; neuroprotection; proteolysis; SBDP; serum; TBI ID ALPHA-II-SPECTRIN; C-TERMINAL HYDROLASE; CEREBRAL-ARTERY OCCLUSION; CYCLOSPORINE-A; NEUROSURGICAL INTERVENTION; TRANSFORMING RESEARCH; INTRACRANIAL LESIONS; ALZHEIMERS-DISEASE; CLINICAL KNOWLEDGE; PROTEOMIC ANALYSIS AB Acute traumatic brain injury (TBI) is associated with neurological dysfunction, changes in brain proteins, and increased serum biomarkers. However, the relationship between these brain proteins and serum biomarkers, and the ability of these serum biomarkers to indicate a neuroprotective/therapeutic response, remains elusive. Penetrating ballistic-like brain injury (PBBI) was used to systematically analyze several key TBI biomarkers, glial fibrillary acidic protein (GFAP) and its break-down products (BDPs)ubiquitin C-terminal hydrolase-L1 (UCH-L1), -II spectrin, and -II spectrin BDPs (SBDPs)in brain tissues and serum during an extended acute-subacute time-frame. In addition, neurological improvement and serum GFAP theranostic value was evaluated after neuroprotective treatment. In brain tissues, total GFAP increased more than three-fold 2 to 7 d after PBBI. However, this change was primarily due to GFAP-BDPs which increased to 2.7-4.8 arbitrary units (AU). Alpha-II spectrin was nearly ablated 3 d after PBBI, but somewhat recovered after 7 d. In conjunction with -II spectrin loss, SBDP-145/150 increased approximately three-fold 2 to 7 d after PBBI (vs. sham, p<0.05). UCH-L1 protein levels were slightly decreased 7 d after PBBI but otherwise were unaffected. Serum GFAP was elevated by 3.2- to 8.8-fold at 2 to 4h (vs. sham; p<0.05) and the 4h increase was strongly correlated to 3 d GFAP-BDP abundance (r=0.66; p<0.05). Serum GFAP showed such a strong injury effect that it also was evaluated after therapeutic intervention with cyclosporin A (CsA). Administration of 2.5mg/kg CsA significantly reduced serum GFAP elevation by 22.4-fold 2h after PBBI (vs. PBBI+vehicle; p<0.05) and improved neurological function 1 d post-injury. Serum biomarkers, particularly GFAP, may be correlative tools of brain protein changes and feasible theranostic markers of TBI progression and recovery. C1 [Boutte, Angela M.; Deng-Bryant, Ying; Johnson, David; Tortella, Frank C.; Dave, Jitendra R.; Shear, Deborah A.; Schmid, Kara E.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect & Neurorestorat Branch, Silver Spring, MD 20910 USA. RP Boutte, AM (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect & Neurorestorat Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM angela.m.boutte.civ@mail.mil FU Combat Casualty Care Research Program; Congressionally Directed Medical Research Program [W81XWH-12-2-0134] FX The views of the authors do not purport or reflect the position of the Department of the Army or the Department of Defense (para 43, AR 360-5). This research is funded by Combat Casualty Care Research Program and Congressionally Directed Medical Research Program (Contract #: W81XWH-12-2-0134). The authors thank Ms. Shonnette Grant, M.S.; SGT Myint, US Army; SPC Donkor, US Army; Ms. Rebecca Pedersen; and Mr. Francis Bustos for their technical expertise, as well as Dr. Ryan Readnower and Dr. Cartagena for their invaluable advice. NR 51 TC 4 Z9 4 U1 0 U2 3 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JAN 1 PY 2016 VL 33 IS 1 BP 147 EP 156 DI 10.1089/neu.2014.3672 PG 10 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA CZ4EW UT WOS:000367057200017 PM 25789543 ER PT J AU Patterson, AT Kaffenberger, BH Keller, RA Elston, DM AF Patterson, Andrew T. Kaffenberger, Benjamin H. Keller, Richard A. Elston, Dirk M. TI Skin diseases associated with Agent Orange and other organochlorine exposures SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Review DE Agent Orange; chloracne; dioxin exposure; organochlorine; skin disease; veteran; Vietnam; 2,3,7,8-tetrachlorodibenzo-p-dioxin ID OPERATION RANCH HAND; PORPHYRIA-CUTANEA-TARDA; CHEMICAL CORPS VIETNAM; NON-HODGKINS-LYMPHOMA; AIR-FORCE VETERANS; 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN TCDD INTOXICATION; TRICHLOROPHENOL PROCESS ACCIDENT; CHRONIC HEPATIC PORPHYRIA; UNITED-STATES MILITARY; SOFT-TISSUE SARCOMA AB Organochlorine exposure is an important cause of cutaneous and systemic toxicity. Exposure has been associated with industrial accidents, intentional poisoning, and the use of defoliants, such as Agent Orange in the Vietnam War. Although long-term health effects are systematically reviewed by the Institute of Medicine, skin diseases are not comprehensively assessed. This represents an important practice gap as patients can present with cutaneous findings. This article provides a systematic review of the cutaneous manifestations of known mass organochlorine exposures in military and industrial settings with the goal of providing clinically useful recommendations for dermatologists seeing patients inquiring about organochlorine effects. Patients with a new diagnosis of chloracne, porphyria cutanea tarda, cutaneous lymphomas (non-Hodgkin lymphoma), and soft-tissue sarcomas including dermatofibrosarcoma protuberans and leiomyosarcomas should be screened for a history of Vietnam service or industrial exposure. Inconclusive evidence exists for an increased risk of other skin diseases in Vietnam veterans exposed to Agent Orange including benign fatty tumors, melanomas, nonmelanoma skin cancers, milia, eczema, dyschromias, disturbance of skin sensation, and rashes not otherwise specified. Affected veterans should be informed of the uncertain data in those cases. Referral to Department of Veterans Affairs for disability assessment is indicated for conditions with established associations. C1 [Patterson, Andrew T.; Kaffenberger, Benjamin H.] Ohio State Univ, Coll Med, Div Dermatol, Columbus, OH 43212 USA. [Patterson, Andrew T.] US Air Force, San Antonio Mil Med Ctr, San Antonio, TX USA. [Keller, Richard A.] US Air Force, Audie L Murphy Vet Hosp, Dermatol, Washington, DC USA. [Elston, Dirk M.] Ackerman Acad Dermatopathol, New York, NY USA. [Elston, Dirk M.] US Army, New York, NY USA. RP Kaffenberger, BH (reprint author), Ohio State Univ, Dermatol, 915 Olentangy River Rd,Suite 4000, Columbus, OH 43212 USA. EM Benjamin.Kaffenberger@osumc.edu NR 143 TC 0 Z9 0 U1 6 U2 20 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD JAN PY 2016 VL 74 IS 1 BP 143 EP 170 DI 10.1016/j.jaad.2015.05.006 PG 28 WC Dermatology SC Dermatology GA CZ4IF UT WOS:000367066000024 PM 26210237 ER PT J AU Holtsberg, FW Shulenin, S Vu, H Howell, KA Patel, SJ Gunn, B Karim, M Lai, JR Frei, JC Nyakatura, EK Zeitlin, L Douglas, R Fusco, ML Froude, JW Saphire, EO Herbert, AS Wirchnianski, AS Lear-Rooney, CM Alter, G Dye, JM Glass, PJ Warfield, KL Aman, MJ AF Holtsberg, Frederick W. Shulenin, Sergey Hong Vu Howell, Katie A. Patel, Sonal J. Gunn, Bronwyn Karim, Marcus Lai, Jonathan R. Frei, Julia C. Nyakatura, Elisabeth K. Zeitlin, Larry Douglas, Robin Fusco, Marnie L. Froude, Jeffrey W. Saphire, Erica Ollmann Herbert, Andrew S. Wirchnianski, Ariel S. Lear-Rooney, Calli M. Alter, Galit Dye, John M. Glass, Pamela J. Warfield, Kelly L. Aman, M. Javad TI Pan-ebolavirus and Pan-filovirus Mouse Monoclonal Antibodies: Protection against Ebola and Sudan Viruses SO JOURNAL OF VIROLOGY LA English DT Article ID FC-GAMMA-RIII; NONHUMAN-PRIMATES; HEMORRHAGIC-FEVER; INFECTION; DISEASE; MICE; GLYCOPROTEIN; PROPHYLAXIS; AFRICA; MODEL AB The unprecedented 2014-2015 Ebola virus disease (EVD) outbreak in West Africa has highlighted the need for effective therapeutics against filoviruses. Monoclonal antibody (MAb) cocktails have shown great potential as EVD therapeutics; however, the existing protective MAbs are virus species specific. Here we report the development of pan-ebolavirus and pan-filovirus antibodies generated by repeated immunization of mice with filovirus glycoproteins engineered to drive the B cell responses toward conserved epitopes. Multiple pan-ebolavirus antibodies were identified that react to the Ebola, Sudan, Bundibugyo, and Reston viruses. A pan-filovirus antibody that was reactive to the receptor binding regions of all filovirus glycoproteins was also identified. Significant postexposure efficacy of several MAbs, including a novel antibody cocktail, was demonstrated. For the first time, we report cross-neutralization and in vivo protection against two highly divergent filovirus species, i.e., Ebola virus and Sudan virus, with a single antibody. Competition studies indicate that this antibody targets a previously unrecognized conserved neutralizing epitope that involves the glycan cap. Mechanistic studies indicated that, besides neutralization, innate immune cell effector functions may play a role in the antiviral activity of the antibodies. Our findings further suggest critical novel epitopes that can be utilized to design effective cocktails for broad protection against multiple filovirus species. C1 [Holtsberg, Frederick W.; Shulenin, Sergey; Hong Vu; Howell, Katie A.; Patel, Sonal J.; Douglas, Robin; Warfield, Kelly L.; Aman, M. Javad] Integrated BioTherapeut Inc, Gaithersburg, MD 20878 USA. [Gunn, Bronwyn; Karim, Marcus; Alter, Galit] Ragon Inst Massachusetts Gen Hosp Massachusetts I, Boston, MA USA. [Lai, Jonathan R.; Frei, Julia C.; Nyakatura, Elisabeth K.] Albert Einstein Coll Med, New York, NY USA. [Zeitlin, Larry] Mapp Biopharmaceut, San Diego, CA USA. [Fusco, Marnie L.; Saphire, Erica Ollmann] Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA USA. [Froude, Jeffrey W.; Herbert, Andrew S.; Wirchnianski, Ariel S.; Lear-Rooney, Calli M.; Dye, John M.; Glass, Pamela J.] US Army Med Res Inst Infect Dis, Frederick, MD USA. RP Aman, MJ (reprint author), Integrated BioTherapeut Inc, Gaithersburg, MD 20878 USA. EM javad@integratedbiotherapeutics.com FU HHS \ NIH \ National Institute of Allergy and Infectious Diseases (NIAID) [R01 AI067927, U19 AI109762]; DOD \ Defense Threat Reduction Agency (DTRA) [HD-TRA1-13-C-0015] FX HHS vertical bar NIH vertical bar National Institute of Allergy and Infectious Diseases (NIAID) provided funding to Erica Oilmann Saphire under grant numbers R01 AI067927 and U19 AI109762. DOD vertical bar Defense Threat Reduction Agency (DTRA) provided funding to M. Javad Aman under grant number HD-TRA1-13-C-0015. NR 49 TC 11 Z9 11 U1 7 U2 17 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X EI 1098-5514 J9 J VIROL JI J. Virol. PD JAN PY 2016 VL 90 IS 1 BP 266 EP 278 DI 10.1128/JVI.02171-15 PG 13 WC Virology SC Virology GA CZ1XK UT WOS:000366899000024 PM 26468533 ER PT J AU Keck, ZY Enterlein, SG Howell, KA Vu, H Shulenin, S Warfield, KL Froude, JW Araghi, N Douglas, R Biggins, J Lear-Rooney, CM Wirchnianski, AS Lau, P Wang, Y Herbert, AS Dye, JM Glass, PJ Holtsberg, FW Foung, SKH Aman, MJ AF Keck, Zhen-Yong Enterlein, Sven G. Howell, Katie A. Hong Vu Shulenin, Sergey Warfield, Kelly L. Froude, Jeffrey W. Araghi, Nazli Douglas, Robin Biggins, Julia Lear-Rooney, Calli M. Wirchnianski, Ariel S. Lau, Patrick Wang, Yong Herbert, Andrew S. Dye, John M. Glass, Pamela J. Holtsberg, Frederick W. Foung, Steven K. H. Aman, M. Javad TI Macaque Monoclonal Antibodies Targeting Novel Conserved Epitopes within Filovirus Glycoprotein SO JOURNAL OF VIROLOGY LA English DT Article ID EBOLA-VIRUS INFECTION; NIEMANN-PICK C1; NONHUMAN-PRIMATES; GUINEA-PIGS; B-CELLS; HEMORRHAGIC-FEVER; PARTICLES PROTECT; MOUSE MODEL; MICE; PROPHYLAXIS AB Filoviruses cause highly lethal viral hemorrhagic fever in humans and nonhuman primates. Current immunotherapeutic options for filoviruses are mostly specific to Ebola virus (EBOV), although other members of Filoviridae such as Sudan virus (SUDV), Bundibugyo virus (BDBV), and Marburg virus (MARV) have also caused sizeable human outbreaks. Here we report a set of pan-ebolavirus and pan-filovirus monoclonal antibodies (MAbs) derived from cynomolgus macaques immunized repeatedly with a mixture of engineered glycoproteins (GPs) and virus-like particles (VLPs) for three different filovirus species. The antibodies recognize novel neutralizing and nonneutralizing epitopes on the filovirus glycoprotein, including conserved conformational epitopes within the core regions of the CP1 subunit and a novel linear epitope within the glycan cap. We further report the first filovirus antibody binding to a highly conserved epitope within the fusion loop of ebolavirus and marburgvirus species. One of the antibodies binding to the core CP1 region of all ebolavirus species and with lower affinity to MARV GP cross neutralized both SUDV and EBOV, the most divergent ebolavirus species. In a mouse model of EBOV infection, this antibody provided 100% protection when administered in two doses and partial, but significant, protection when given once at the peak of viremia 3 days postinfection. Furthermore, we describe novel cocktails of antibodies with enhanced protective efficacy compared to individual MAbs. In summary, the present work describes multiple novel, cross-reactive filovirus epitopes and innovative combination concepts that challenge the current therapeutic models. C1 [Enterlein, Sven G.; Howell, Katie A.; Hong Vu; Shulenin, Sergey; Warfield, Kelly L.; Araghi, Nazli; Douglas, Robin; Biggins, Julia; Holtsberg, Frederick W.; Aman, M. Javad] Integrated BioTherapeut Inc, Gaithersburg, MD 20878 USA. [Keck, Zhen-Yong; Lau, Patrick; Wang, Yong; Foung, Steven K. H.] Stanford Univ, Dept Pathol, Stanford, CA 94305 USA. [Froude, Jeffrey W.; Lear-Rooney, Calli M.; Wirchnianski, Ariel S.; Herbert, Andrew S.; Dye, John M.; Glass, Pamela J.] US Army Med Res Inst Infect Dis, Frederick, MD USA. RP Aman, MJ (reprint author), Integrated BioTherapeut Inc, Gaithersburg, MD 20878 USA. EM javad@integratedbiotherapeutics.com FU HHS \ NIH \ National Institute of Allergy and Infectious Diseases (NIAID) [R43AI098178]; DOD \ Defense Threat Reduction Agency (DTRA) [HDTRA1-13-C-0015] FX HHS vertical bar NIH vertical bar National Institute of Allergy and Infectious Diseases (NIAID) provided funding to Sven G Enterlein under grant number R43AI098178. DOD vertical bar Defense Threat Reduction Agency (DTRA) provided funding to M. Javad Aman under grant number HDTRA1-13-C-0015. NR 48 TC 5 Z9 5 U1 3 U2 4 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X EI 1098-5514 J9 J VIROL JI J. Virol. PD JAN PY 2016 VL 90 IS 1 BP 279 EP 291 DI 10.1128/JVI.02172-15 PG 13 WC Virology SC Virology GA CZ1XK UT WOS:000366899000025 PM 26468532 ER PT J AU Devita, P Fellin, RE Seay, JF Ip, E Stavro, N Messier, SP AF Devita, Paul Fellin, Rebecca E. Seay, Joseph F. Ip, Edward Stavro, Nicole Messier, Stephen P. TI The Relationships between Age and Running Biomechanics SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE OLDER RUNNERS; JOINT TORQUE; POWER; AGING; GAIT ID GROUND REACTION FORCES; PHYSICAL-ACTIVITY; LOWER-EXTREMITY; MORPHOLOGICAL PROPERTIES; MUSCLE STRENGTH; MASTERS RUNNERS; ELDERLY RUNNERS; WOMEN; DISTANCE; MEN AB Running has high injury rates, especially among older runners. Most aging literature compares young with old runners without accounting for the progression of biomechanics throughout the lifespan. We used age as a continuous variable to investigate the continuum of age-related gait adaptations in running along with determining the chronology and rate of these adaptations. Purpose This study aimed to identify the relations among age and selected running biomechanics throughout the range of 18-60 yr. Methods Experienced (n = 110) healthy runners (male, 54%) provided informed consent and ran at their training pace while motion and force data were captured. Kinematics, ground reaction forces (GRF), and lower limb joint torques and powers were correlated with age using Pearson product-moment correlations and linear regression. Results Running velocity was inversely related to age (r = -0.27, P = 0.005) because of decreased stride length (r = -0.25, P = 0.008) but not rate. Peak vertical GRF (r = -0.23, P = 0.016) and peak horizontal propulsive GRF decreased with age (r = -0.38, P < 0.0001). Peak ankle torque (r = -0.32, P = 0.0007) and peak negative (r = 0.34, P = 0.0003) and positive (r = -0.37, P < 0.0001) ankle power decreased with age. Age-based regression equations and per-year reductions in all variables significantly related to age are reported. Conclusions Data support previous work showing lower GRF, stride length, and velocity in old runners. Results are novel in showing the rate of decline in running biomechanics on a per-year basis and that mechanical reductions at the ankle but not at the hip or knee were correlated with age, confirming a previous observation of biomechanical plasticity with age showing reduced ankle but not hip function in gait. C1 [Devita, Paul] E Carolina Univ, Dept Kinesiol, Greenville, NC 27858 USA. [Fellin, Rebecca E.; Seay, Joseph F.] US Army, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. [Ip, Edward] Wake Forest Sch Med, Dept Biostat Sci, Winston Salem, NC USA. [Ip, Edward] Wake Forest Sch Med, Dept Social Sci & Hlth Policy, Winston Salem, NC USA. [Stavro, Nicole; Messier, Stephen P.] Wake Forest Univ, Dept Hlth & Exercise Sci, Winston Salem, NC 27109 USA. RP Devita, P (reprint author), E Carolina Univ, Dept Kinesiol, 332 Ward Sports Med Bldg, Greenville, NC 27858 USA. EM devitap@ecu.edu FU USAMRAA (US Army) [W81XWH-10-1-0455]; US Army Research Institute of Environmental Medicine FX This study was sponsored by grant W81XWH-10-1-0455, USAMRAA (US Army). Research supported partly by an appointment to the Postgraduate Research Participation Program (REF) funded by the US Army Research Institute of Environmental Medicine and administered by Oak Ridge Institute for Science and Engineering. The authors report no conflict of interest. Citations of commercial organizations and trade names in this report do not constitute an official Department of the Army endorsement or approval of the products or services of these organizations. The results of the present study do not constitute endorsement by the American College of Sports Medicine. NR 49 TC 4 Z9 4 U1 5 U2 19 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD JAN PY 2016 VL 48 IS 1 BP 98 EP 106 DI 10.1249/MSS.0000000000000744 PG 9 WC Sport Sciences SC Sport Sciences GA CY7LO UT WOS:000366590100014 PM 26258853 ER PT J AU Poff, NL Brown, CM Grantham, T Matthews, JH Palmer, MA Spence, CM Wilby, RL Haasnoot, M Mendoza, GF Dominique, KC Baeza, A AF Poff, N. LeRoy Brown, Casey M. Grantham, TheodoreE. Matthews, John H. Palmer, Margaret A. Spence, Caitlin M. Wilby, Robert L. Haasnoot, Marjolijn Mendoza, Guillermo F. Dominique, Kathleen C. Baeza, Andres TI Sustainable water management under future uncertainty with eco-engineering decision scaling SO NATURE CLIMATE CHANGE LA English DT Article ID GENERAL-CIRCULATION MODELS; CLIMATE-CHANGE; ECOLOGICAL CONSEQUENCES; ENVIRONMENTAL FLOWS; BASIC PRINCIPLES; CHANGING WORLD; UNITED-STATES; BIODIVERSITY; RESILIENCE; ADAPTATION AB Managing freshwater resources sustainably under future climatic and hydrological uncertainty poses novel challenges. Rehabilitation of ageing infrastructure and construction of new dams are widely viewed as solutions to diminish climate risk, but attaining the broad goal of freshwater sustainability will require expansion of the prevailing water resources management paradigm beyond narrow economic criteria to include socially valued ecosystem functions and services. We introduce a new decision framework, eco-engineering decision scaling (EEDS), that explicitly and quantitatively explores trade-offs in stake-holder-defined engineering and ecological performance metrics across a range of possible management actions under unknown future hydrological and climate states. We illustrate its potential application through a hypothetical case study of the Iowa River, USA. EEDS holds promise as a powerful framework for operationalizing freshwater sustainability under future hydrological uncertainty by fostering collaboration across historically conflicting perspectives of water resource engineering and river conservation ecology to design and operate water infrastructure for social and environmental benefits. C1 [Poff, N. LeRoy] Colorado State Univ, Dept Biol, Ft Collins, CO 80523 USA. [Poff, N. LeRoy; Spence, Caitlin M.] Colorado State Univ, Grad Degree Program Ecol, Ft Collins, CO 80523 USA. [Brown, Casey M.; Spence, Caitlin M.] Univ Massachusetts, Civil & Environm Engn, Amherst, MA 01003 USA. [Grantham, TheodoreE.] US Geol Survey, Ft Collins Sci Ctr, Ft Collins, CO 80526 USA. [Matthews, John H.] Alliance Global Water Adaptat, Orlando, FL USA. [Palmer, Margaret A.] Univ Maryland, Natl Socioenvironm Synth Ctr, Annapolis, MD 21401 USA. [Wilby, Robert L.] Univ Loughborough, Dept Geog, Loughborough LE11 3TU, Leics, England. [Haasnoot, Marjolijn] Deltares, Dept Scenarios & Policy Anal, NL-2600 MH Delft, Netherlands. [Haasnoot, Marjolijn] Delft Univ Technol, Fac Technol Policy & Management, NL-2600 GA Delft, Netherlands. [Mendoza, Guillermo F.] US Army Corps Engineers, Inst Water Resources, Alexandria, VA 22315 USA. [Dominique, Kathleen C.] Org Econ Cooperat & Dev, F-75775 Paris, France. [Baeza, Andres] Natl Socioenvironm Synth Ctr, Annapolis, MD 21401 USA. RP Poff, NL (reprint author), Colorado State Univ, Dept Biol, Campus Mail 1878, Ft Collins, CO 80523 USA. EM NLeRoy.Poff@colostate.edu OI Haasnoot, Marjolijn/0000-0002-9062-4698; matthews, john/0000-0002-7005-2661 FU NSF CAREER Award [CBET-1054762]; National Socio-Environmental Synthesis Center (SESYNC) under National Science Foundation [DBI-1052875] FX We acknowledge S. Steinschneider for developing the stochastic weather generator for the Iowa River Basin; S. Wi for the VIC hydrologic model development; D. LeFever for support in developing the reservoir systems model; and R. Olsen for his help in providing hydraulic modelling tools and economic information for the Coralville Lake flood control system. Special thanks to P. Clark for artwork in Fig. 1. Additional support for C.M.B. and C.M.S was provided by the NSF CAREER Award (CBET-1054762). The views in this article are those of the authors and do not necessarily represent the views of the OECD or its member countries. This article has been peer reviewed and approved for publication consistent with USGS Fundamental Science Practices (http://pubs.usgs.gov/circ/1367/) and we thank J. Friedman of the USGS for his constructive comments. Any use of trade, firm, or product names is for descriptive purposes only and does not imply endorsement by the U.S. Government. This paper resulted from a synthesis project funded by the National Socio-Environmental Synthesis Center (SESYNC) under National Science Foundation Award #DBI-1052875. NR 90 TC 17 Z9 17 U1 26 U2 76 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1758-678X EI 1758-6798 J9 NAT CLIM CHANGE JI Nat. Clim. Chang. PD JAN PY 2016 VL 6 IS 1 BP 25 EP 34 DI 10.1038/NCLIMATE2765 PG 10 WC Environmental Sciences; Environmental Studies; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA CZ3UZ UT WOS:000367030800014 ER PT J AU Tarney, CM AF Tarney, Christopher M. TI Association of Spouse Deployment on Pregnancy Outcomes in a US Military Population Reply SO OBSTETRICS AND GYNECOLOGY LA English DT Letter C1 [Tarney, Christopher M.] Womack Army Med Ctr, Dept Obstet & Gynecol, Ft Bragg, NC 28307 USA. RP Tarney, CM (reprint author), Womack Army Med Ctr, Dept Obstet & Gynecol, Ft Bragg, NC 28307 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD JAN PY 2016 VL 127 IS 1 BP 164 EP 164 PG 1 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA CZ2DG UT WOS:000366914700018 PM 26695570 ER PT J AU Castellani, JW Tipton, MJ AF Castellani, John W. Tipton, Michael J. TI Cold Stress Effects on Exposure Tolerance and Exercise Performance SO COMPREHENSIVE PHYSIOLOGY LA English DT Article ID REFLEX CUTANEOUS VASOCONSTRICTION; HUMAN THERMOREGULATORY RESPONSES; PROLONGED INTERMITTENT WALKING; CHILL EQUIVALENT TEMPERATURE; SURVIVAL-TIME PREDICTION; BROWN ADIPOSE-TISSUE; BODY HEAT-CONTENT; WATER IMMERSION; INITIAL RESPONSES; PHYSIOLOGICAL-RESPONSES AB Cold weather can have deleterious effects on health, tolerance, and performance. This paper will review the physiological responses and external factors that impact cold tolerance and physical performance. Tolerance is defined as the ability to withstand cold stress with minimal changes in physiological strain. Physiological and pathophysiological responses to short-term (cold shock) and long-term cold water and air exposure are presented. Factors (habituation, anthropometry, sex, race, and fitness) that influence cold tolerance are also reviewed. The impact of cold exposure on physical performance, especially aerobic performance, has not been thoroughly studied. The few studies that have been done suggest that aerobic performance is degraded in cold environments. Potential physiological mechanisms (decreases in deep body and muscle temperature, cardiovascular, and metabolism) are discussed. Likewise, strength and power are also degraded during cold exposure, primarily through a decline in muscle temperature. The review also discusses the concept of thermoregulatory fatigue, a reduction in the thermal effector responses of shivering and vasoconstriction, as a result of multistressor factors, including exhaustive exercise. (C) 2016 American Physiological Society. C1 [Castellani, John W.] US Army Res Inst Environm Med, Thermal & Mt Med Div, Natick, MA 01760 USA. [Tipton, Michael J.] Univ Portsmouth, Dept Exercise & Sport Sci, Extreme Environm Lab, Portsmouth, Hants, England. RP Castellani, JW (reprint author), US Army Res Inst Environm Med, Thermal & Mt Med Div, Natick, MA 01760 USA. EM john.w.castellani.civ@mail.mil NR 279 TC 3 Z9 3 U1 25 U2 71 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 2040-4603 J9 COMPR PHYSIOL JI Compr. Physiol. PD JAN PY 2016 VL 6 IS 1 BP 443 EP 469 DI 10.1002/cphy.c140081 PG 27 WC Physiology SC Physiology GA CY8GS UT WOS:000366647400015 PM 26756639 ER PT J AU Murillo, JSR Mohamed, A Hodo, W Mohan, RV Rajendran, A Valisetty, R AF Murillo, John S. Rivas Mohamed, Ahmed Hodo, Wayne Mohan, Ram V. Rajendran, A. Valisetty, R. TI Computational modeling of shear deformation and failure of nanoscale hydrated calcium silicate hydrate in cement paste: Calcium silicate hydrate Jennite SO INTERNATIONAL JOURNAL OF DAMAGE MECHANICS LA English DT Article DE Material chemistry level modeling; cement; molecular dynamics; multi-scale modeling; deformation and failure; calcium silicate hydrate ID C-S-H; PORTLAND-CEMENT; ELASTIC PROPERTIES; TRICALCIUM SILICATE; BLENDS; SLAG AB Calcium silicate hydrate Jennite is a molecular structure commonly accepted as a representation of the complex calcium silicate hydrate gel formed during the hydration of typical Portland cement. In this paper, the behavior of nanoscale calcium silicate hydrate Jennite under shear deformation was investigated using molecular dynamics simulations. Computational samples representing the nanoscale structure of calcium silicate hydrate Jennite were subjected to shear deformation in order to investigate not only their mechanical properties but also their deformation behavior. The simulation results indicated that the nanoscale calcium silicate hydrate Jennite under shear deformation displays a linear elastic behavior up to shear stress of approximately 1.0GPa, and shear deformation of about 0.08 radians, after which point yielding and plastic deformation occurs. The shear modulus determined from the simulations was 11.2 +/- 0.7GPa. The deformation-induced displacements in molecular structures were analyzed dividing the system in regions representing calcium oxide layers. The displacement/deformation of the layers of calcium oxide forming the structure of nanoscale calcium silicate hydrate Jennite was analyzed. The non-linear stress-strain behavior in the molecular structure was attributed to a non-linear increase in the displacement due to sliding of the calcium oxide layers on top of each other with higher shearing. These results support the idea that by controlling the chemical reactions, the tailored morphologies can be used to increase the interlinking between the calcium oxide layers, thus minimizing the shearing of the layers and leading to molecular structures that can withstand larger deformation and have improved failure behavior. C1 [Murillo, John S. Rivas; Mohamed, Ahmed; Mohan, Ram V.] North Carolina A&T State Univ, Joint Sch Nanosci & Nanoengn, Nanoengn Dept, Greensboro, NC 27401 USA. [Hodo, Wayne] Engn Res & Dev Ctr, Vicksburg, MS USA. [Rajendran, A.] Univ Mississippi, Dept Mech Engn, Oxford, MS USA. [Valisetty, R.] US Army Res Lab, Baltimore, MD USA. RP Mohan, RV (reprint author), North Carolina A&T State Univ, Joint Sch Nanosci & Nanoengn, Nanoengn Dept, 2907 E Lee St, Greensboro, NC 27401 USA. EM rvmohan@ncat.edu FU U.S. Army Research Office [W911NF-11-2-0043]; U.S. Army Engineering Research and Development Center's Military Engineering Basic/Applied "MMFP" Research Program FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The authors from North Carolina A&T State University, Greensboro, and University of Mississippi, Oxford, acknowledge the support by the U.S. Army Research Office under a cooperative agreement award contract No. W911NF-11-2-0043 (Program Manager: Dr. Joseph Myers), and the U.S. Army Engineering Research and Development Center's Military Engineering Basic/Applied "MMFP" Research Program. NR 36 TC 0 Z9 0 U1 3 U2 10 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1056-7895 EI 1530-7921 J9 INT J DAMAGE MECH JI Int. J. Damage Mech. PD JAN PY 2016 VL 25 IS 1 SI SI BP 98 EP 114 DI 10.1177/1056789515580184 PG 17 WC Materials Science, Multidisciplinary; Mechanics SC Materials Science; Mechanics GA CY7SM UT WOS:000366609200008 ER PT J AU Servinsky, MD Terrell, JL Tsao, CY Wu, HC Quan, DN Zargar, A Allen, PC Byrd, CM Sund, CJ Bentley, WE AF Servinsky, Matthew D. Terrell, Jessica L. Tsao, Chen-Yu Wu, Hsuan-Chen Quan, David N. Zargar, Amin Allen, Patrick C. Byrd, Christopher M. Sund, Christian J. Bentley, William E. TI Directed assembly of a bacterial quorum SO ISME JOURNAL LA English DT Article ID ESCHERICHIA-COLI K-12; GENE-EXPRESSION; VIBRIO-HARVEYI; BIOFILM FORMATION; AUTOINDUCER AI-2; LUXS; COMMUNICATION; DENSITY; REGULATORS; SYSTEM AB Many reports have elucidated the mechanisms and consequences of bacterial quorum sensing (QS), a molecular communication system by which bacterial cells enumerate their cell density and organize collective behavior. In few cases, however, the numbers of bacteria exhibiting this collective behavior have been reported, either as a number concentration or a fraction of the whole. Not all cells in the population, for example, take on the collective phenotype. Thus, the specific attribution of the postulated benefit can remain obscure. This is partly due to our inability to independently assemble a defined quorum, for natural and most artificial systems the quorum itself is a consequence of the biological context (niche and signaling mechanisms). Here, we describe the intentional assembly of quantized quorums. These are made possible by independently engineering the autoinducer signal transduction cascade of Escherichia coli (E. coli) and the sensitivity of detector cells so that upon encountering a particular autoinducer level, a discretized sub-population of cells emerges with the desired phenotype. In our case, the emergent cells all express an equivalent amount of marker protein, DsRed, as an indicator of a specific QS-mediated activity. The process is robust, as detector cells are engineered to target both large and small quorums. The process takes about 6 h, irrespective of quorum level. We demonstrate sensitive detection of autoinducer-2 (AI-2) as an application stemming from quantized quorums. We then demonstrate sub-population partitioning in that AI-2-secreting cells can 'call' groups neighboring cells that 'travel' and establish a QS-mediated phenotype upon reaching the new locale. C1 [Servinsky, Matthew D.; Allen, Patrick C.; Byrd, Christopher M.; Sund, Christian J.] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD USA. [Terrell, Jessica L.; Tsao, Chen-Yu; Wu, Hsuan-Chen; Quan, David N.; Zargar, Amin; Byrd, Christopher M.; Bentley, William E.] Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA. [Terrell, Jessica L.; Tsao, Chen-Yu; Wu, Hsuan-Chen; Quan, David N.; Zargar, Amin; Byrd, Christopher M.; Bentley, William E.] Univ Maryland, Inst Biosci & Biotechnol Res, College Pk, MD 20742 USA. RP Bentley, WE (reprint author), Univ Maryland, Fischell Dept Bioengn, 2330 Jeong H Kim Engn Bldg, College Pk, MD 20742 USA. EM bentley@umd.edu OI WU, HSUAN-CHEN/0000-0002-7837-1333 FU Defense Threat Reduction Agency (DTRA) [HDTRA1-13-1-0037]; National Science Foundation [CBET 1264509, CBET 1160005]; RW Deutsch Foundation FX We acknowledge support of the Defense Threat Reduction Agency (DTRA, HDTRA1-13-1-0037), the National Science Foundation (CBET 1264509 & CBET 1160005) and the RW Deutsch Foundation. NR 54 TC 6 Z9 6 U1 7 U2 37 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1751-7362 EI 1751-7370 J9 ISME J JI ISME J. PD JAN PY 2016 VL 10 IS 1 BP 158 EP 169 DI 10.1038/ismej.2015.89 PG 12 WC Ecology; Microbiology SC Environmental Sciences & Ecology; Microbiology GA CY8PR UT WOS:000366671300016 PM 26046256 ER PT J AU Sailasuta, N Ananworanich, J Lerdlum, S Sithinamsuwan, P Fletcher, JLK Tipsuk, S Pothisri, M Jadwattanakul, T Jirajariyavej, S Chalermchai, T Catella, S Busovaca, E Desai, A Paul, R Valcour, V AF Sailasuta, Napapon Ananworanich, Jintanat Lerdlum, Sukalaya Sithinamsuwan, Pasiri Fletcher, James L. K. Tipsuk, Somporn Pothisri, Mantana Jadwattanakul, Tanate Jirajariyavej, Supunnee Chalermchai, Thep Catella, Stephanie Busovaca, Edgar Desai, Akash Paul, Robert Valcour, Victor CA SEARCH 011 Study Grp TI Neuronal-Glia Markers by Magnetic Resonance Spectroscopy in HIV Before and After Combination Antiretroviral Therapy SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE HIV; magnetic resonance spectroscopy; cognitive disorders ID CEREBRAL METABOLITE ABNORMALITIES; HUMAN-IMMUNODEFICIENCY-VIRUS; GAMMA-AMINOBUTYRIC-ACID; PROTON MR SPECTROSCOPY; AIDS DEMENTIA COMPLEX; TE-AVERAGED PRESS; NEUROCOGNITIVE DISORDERS; POSITIVE PATIENTS; INFECTED PATIENTS; FRONTAL-LOBE AB Objective:Combination antiretroviral therapy (cART) can suppress plasma HIV RNA to undetectable levels; yet reports indicate persistent HIV-associated neurocognitive disorders (HAND) among treated individuals. We sought to investigate imaging correlates of incomplete cognitive recovery among individuals with chronic HIV.Methods:We used single voxel proton magnetic resonance spectroscopy in 4 regions of the brain to measure changes in neuronal and glia biomarkers in cART-naive subjects before (n = 59, 27 with HAND) and after 12 months of cART.Results:At baseline, we observed elevated total choline (CHO) in the basal ganglia (BG, P = 0.002) and in the posterior cingulate gyrus (PCG, P = 0.022) associated with HIV infection. Myo-inositol (MI) was elevated in the frontal white matter (FWM, P = 0.040). N-acetylaspartate was elevated in the BG (P = 0.047). Using a mixed model approach among all HIV-infected individuals, at 6 months, we observed decreased n- acetylaspartate in FWM (P = 0.031), decreased creatine in PCG (P = 0.026) and increased MI in frontal gray matter (FGM, P = 0.023). At 12 months, we observed an increase in BG MI (P = 0.038) and in FGM (P = 0.021). Compared to those with normal cognition, HAND cases had higher FGM MI (P = 0.014) at baseline. At 12 months, individuals that remained cognitively impaired compared with those without HAND exhibited elevated CHO in the PCG (P = 0.018) and decreased glutamate in both FWM (P = 0.027) and BG (P = 0.013).Conclusions:cART started during chronic HIV is associated with reduced neuronal-glia and inflammatory markers. Alterations in CHO are noted among individuals who remain impaired after 12 months of cART. C1 [Sailasuta, Napapon] Univ Hawaii, Dept Trop Med, Honolulu, HI 96822 USA. [Ananworanich, Jintanat] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Ananworanich, Jintanat] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Ananworanich, Jintanat; Fletcher, James L. K.; Tipsuk, Somporn; Chalermchai, Thep] Thai Red Cross AIDS Res Ctr, SEARCH, Bangkok, Thailand. [Lerdlum, Sukalaya; Pothisri, Mantana] Chulalongkorn Univ, Fac Med, Dept Radiol, Bangkok 10330, Thailand. [Sithinamsuwan, Pasiri] Phramongkutklao Hosp, Div Neurol, Dept Med, Bangkok, Thailand. [Jadwattanakul, Tanate] Queen Savang Vadhana Mem Hosp, Chomburi, Thailand. [Jirajariyavej, Supunnee] Taksin Hosp, Bangkok, Thailand. [Catella, Stephanie; Busovaca, Edgar; Desai, Akash; Valcour, Victor] Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA USA. [Paul, Robert] Univ Missouri, Dept Psychol, Missouri Inst Mental Hlth, St Louis, MO 63121 USA. RP Valcour, V (reprint author), UCSF, Sandler Neurosci Ctr, Memory & Aging Ctr, Room 192C,675 Nelson Rising Lane, San Francisco, CA 94158 USA. EM vvalcour@memory.ucsf.edu FU National Institute of Neurological Disorders and Stroke of the National Institutes of Health [R01 NS061696, R01 NS053359] FX Supported by the National Institute of Neurological Disorders and Stroke of the National Institutes of Health under Awards Number R01 NS061696 and R01 NS053359. NR 58 TC 1 Z9 1 U1 3 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1525-4135 EI 1077-9450 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD JAN 1 PY 2016 VL 71 IS 1 BP 24 EP 30 DI 10.1097/QAI.0000000000000779 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA CY9GL UT WOS:000366715300004 PM 26258565 ER PT J AU Echevarria, A Zaghi, AE Chiarito, V Christenson, R Woodson, S AF Echevarria, Alicia Zaghi, Arash E. Chiarito, Vincent Christenson, Richard Woodson, Stanley TI Experimental Comparison of the Performance and Residual Capacity of CFFT and RC Bridge Columns Subjected to Blasts SO JOURNAL OF BRIDGE ENGINEERING LA English DT Article DE Residual capacity; Blast overpressure confinement; Analytical simulation ID HIGH-STRENGTH CONCRETE; REINFORCED POLYMER TUBES; FILLED STEEL TUBE; SEISMIC PERFORMANCE; CONFINED CONCRETE; COMPOSITE TUBES; FRP; BEHAVIOR; PIERS; MODEL AB The blast performance of concrete-filled fiber-reinforced polymer (FRP) tube (CFFT) bridge columns was studied through a two-phase study comprised of blast and residual axial capacity experiments. Two one-fifth-scale CFFT columns and two one-fifth-scale conventional RC columns having comparable flexural capacities were subjected to distinct levels of explosive loading, causing damage but not complete failure. The blast resilience of the damaged columns was quantified by measuring the residual axial capacity of each column. The damaged CFFT columns exhibited superior strength and ductility retention compared with the damaged RC columns. Additionally, the damaged CFFT columns demonstrated a more predictable axial compressive mode of failure because the exterior FRP tube resisted the shear crack initiation observed in the damaged RC columns. (c) 2015 American Society of Civil Engineers. C1 [Echevarria, Alicia] HNTB Corp, Newark, NJ 07102 USA. [Echevarria, Alicia; Zaghi, Arash E.; Christenson, Richard] Univ Connecticut, Dept Civil & Environm Engn, Storrs, CT 06269 USA. [Chiarito, Vincent; Woodson, Stanley] US Army, Engineer Res & Dev Ctr, Corps Engineers, Vicksburg, MS 39180 USA. RP Echevarria, A (reprint author), HNTB Corp, 2 Gateway Ctr,Suite 1203, Newark, NJ 07102 USA. EM alicia.echevarria@engr.uconn.edu RI Esmaili Zaghi, Arash/K-1023-2014 OI Esmaili Zaghi, Arash/0000-0003-2246-2911 FU U.S. Department of Homeland Security under the DHS HS-STEM Career Development Grant [2008-ST-061-TS002]; National Transportation Security Center of Excellence (NTSCOE) -Department of Homeland Security Centers of Excellence (COE) grant program FX This material is based on work supported by the U.S. Department of Homeland Security under the DHS HS-STEM Career Development Grant Award Number 2008-ST-061-TS002. Funding for the experimental work was also supplied by the National Transportation Security Center of Excellence (NTSCOE) funded by the Department of Homeland Security Centers of Excellence (COE) grant program, administered through the DHS Science and Technology Directorate (S&T) Office of University Programs (OUP). The views and conclusions contained in this document are those of the authors and should not be interpreted as necessarily representing the official policies, either expressed or implied, of the U.S. Department of Homeland Security. Strong support from Prof. Michael Accorsi as PI of the HS-STEM Program is greatly appreciated. Jared Minor, Larry Garrett, Clifford Grey, Arnette Nash, and many others from USACE-ERDC are thanked for the assistance they provided to make these blast tests possible. Special thanks to Matt Smith of National Oilwell Varco for donating the FRP tubes, and Peter Glaude and Serge Doyan for their machining and fabrication work. Also, the assistance provided by Masoud Mehrraoufi and Kevin Zmetra during construction and axial capacity testing is very much appreciated. Permission to publish was granted by Director, Geotechnical & Structures Laboratory. NR 63 TC 1 Z9 1 U1 5 U2 16 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1084-0702 EI 1943-5592 J9 J BRIDGE ENG JI J. Bridge Eng. PD JAN PY 2016 VL 21 IS 1 AR 04015026 DI 10.1061/(ASCE)BE.1943-5592.0000762 PG 15 WC Engineering, Civil SC Engineering GA CY8HP UT WOS:000366649700001 ER PT J AU Cho, H Choi, KK Lee, I Lamb, D AF Cho, Hyunkyoo Choi, K. K. Lee, Ikjin Lamb, David TI Design Sensitivity Method for Sampling-Based RBDO With Varying Standard Deviation SO JOURNAL OF MECHANICAL DESIGN LA English DT Article DE RBDO; varying standard deviation; sampling-based RBDO; score function; tolerance of input random variable ID RELIABILITY ASSESSMENT METHOD; SEQUENTIAL OPTIMIZATION AB Conventional reliability-based design optimization (RBDO) uses the mean of input random variable as its design variable; and the standard deviation (STD) of the random variable is a fixed constant. However, the constant STD may not correctly represent certain RBDO problems well, especially when a specified tolerance of the input random variable is present as a percentage of the mean value. For this kind of design problem, the STD of the input random variable should vary as the corresponding design variable changes. In this paper, a method to calculate the design sensitivity of the probability of failure for RBDO with varying STD is developed. For sampling-based RBDO, which uses Monte Carlo simulation (MCS) for reliability analysis, the design sensitivity of the probability of failure is derived using a first-order score function. The score function contains the effect of the change in the STD in addition to the change in the mean. As copulas are used for the design sensitivity, correlated input random variables also can be used for RBDO with varying STD. Moreover, the design sensitivity can be calculated efficiently during the evaluation of the probability of failure. Using a mathematical example, the accuracy and efficiency of the developed design sensitivity method are verified. The RBDO result for mathematical and physical problems indicates that the developed method provides accurate design sensitivity in the optimization process. C1 [Cho, Hyunkyoo] Univ Iowa, Dept Mech & Ind Engn, Engn Res Facil 218, Iowa City, IA 52242 USA. [Choi, K. K.] Univ Iowa, Dept Mech & Ind Engn, Mem ASME, Iowa City, IA 52242 USA. [Lee, Ikjin] Korea Adv Inst Sci & Technol KAIST, Dept Mech Engn, Daejeon 305701, South Korea. [Lamb, David] US Army, RDECOM TARDEC, Warren, MI 48397 USA. RP Choi, KK (reprint author), Univ Iowa, Dept Mech & Ind Engn, Mem ASME, 2134 SC, Iowa City, IA 52242 USA. EM hyunkyoo-cho@uiowa.edu; kkchoi@engineering.uiowa.edu; ikjin.lee@kaist.ac.kr; david.a.lamb40.civ@mail.mil RI Lee, IkJin/I-4722-2013; Choi, Kyung/B-1512-2008 OI Choi, Kyung/0000-0003-2384-6220 FU University of Iowa; Automotive Research Center (ARC); U.S. Army Tank Automotive Research, Development and Engineering Center (TARDEC) [W56HZV-04-2-0001]; Technology Innovation Program - Ministry of Trade, Industry & Energy (MI, Korea) [10048305] FX Research was supported by the University of Iowa 2013 Ice Commercialization GAP Fund. This research was also partially supported by the Automotive Research Center (ARC) in accordance with Cooperative Agreement No. W56HZV-04-2-0001 U.S. Army Tank Automotive Research, Development and Engineering Center (TARDEC); and the Technology Innovation Program (No. 10048305, Launching Plug-in Digital Analysis Framework for Modular System Design) funded by the Ministry of Trade, Industry & Energy (MI, Korea). These supports are greatly appreciated. NR 28 TC 2 Z9 2 U1 0 U2 0 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 1050-0472 J9 J MECH DESIGN JI J. Mech. Des. PD JAN PY 2016 VL 138 IS 1 AR 011405 DI 10.1115/1.4031829 PG 10 WC Engineering, Mechanical SC Engineering GA CY8CW UT WOS:000366637200007 ER PT J AU Allison, PG Seiter, JM Diaz, A Lindsay, JH Moser, RD Tappero, RV Kennedy, AJ AF Allison, Paul G. Seiter, Jennifer M. Diaz, Alfredo Lindsay, James H. Moser, Robert D. Tappero, Ryan V. Kennedy, Alan J. TI Gastropod (Otala lactea) shell nanomechanical and structural characterization as a biomonitoring tool for dermal and dietary exposure to a model metal SO JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS LA English DT Article DE Biomonitoring; Gastropod; Nanoindentation; Synchrotron; Heavy Metal; X-ray ID HEAVY-METALS; MECHANICAL-PROPERTIES; MOLLUSCAN SHELL; BIOACCUMULATION; TUNGSTEN; POLLUTION; SEA; BIOAVAILABILITY; ACCUMULATION; PERFORMANCE AB Metallic tungsten (W) was initially assumed to be environmentally benign and a green alternative to lead. However, subsequent investigations showed that fishing weights and munitions containing elemental W can fragment and oxidize into complex monomeric and polymeric tungstate (WO4) species in the environment; this led to increased solubility and mobility in soils and increased bioaccumulation potential in plant and animal tissues. Here we expand on the results of our previous research, which examined tungsten toxicity, bioaccumulation, and compartmentalization into organisms, and present in this research that the bioaccumulation of W was related to greater than 50% reduction in the mechanical properties of the snail (Otala lactea), based on depth-sensing nanoindentation. Synchrotron-based X-ray fluorescence maps and X-ray diffraction measurements confirm the integration of Win newly formed layers of the shell matrix with the observed changes in shell biomechanical properties, mineralogical composition, and crystal orientation. With further development, this technology could be employed as a biomonitoring tool for historic metals contamination since unlike the more heavily studied bioaccumulation into soft tissue, shell tissue does not actively eliminate contaminants. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Allison, Paul G.] Univ Alabama, Dept Mech Engn, Tuscaloosa, AL 35406 USA. [Seiter, Jennifer M.; Lindsay, James H.; Kennedy, Alan J.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Diaz, Alfredo] Univ Puerto Rico, Dept Mech Engn, Mayaguez, PR 00681 USA. [Moser, Robert D.] US Army Engineer Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA. [Tappero, Ryan V.] Brookhaven Natl Lab, Natl Synchrotron Light Source, Upton, NY 11973 USA. RP Allison, PG (reprint author), Univ Alabama, Dept Mech Engn, Box 870276, Tuscaloosa, AL 35406 USA. EM pallison@eng.ua.edu FU Army Environmental Quality Technology Basic Research Program [EQI-10-42]; U.S. Department of Energy (DOE) - Geosciences [DE-FG02-92ER14244]; DOE, Office of Science, Office of Basic Energy Sciences [DE-AC02-98CH10886] FX This work was funded by the Army Environmental Quality Technology Basic Research Program (EQI-10-42) (US Army Engineer Research and Development Center, Dr. Elizabeth Ferguson, Technical Director). Portions of this work were performed at Beamline X27A, National Synchrotron Light Source (NSLS), Brookhaven National Laboratory. X27A is supported in part by the U.S. Department of Energy (DOE) - Geosciences (DE-FG02-92ER14244 to the University of Chicago - CARS). Use of the NSLS was supported by the DOE, Office of Science, Office of Basic Energy Sciences, under Contract no. DE-AC02-98CH10886. Permission to publish granted by Director of the Geotechnical and Structures Laboratory. NR 49 TC 0 Z9 0 U1 5 U2 15 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1751-6161 EI 1878-0180 J9 J MECH BEHAV BIOMED JI J. Mech. Behav. Biomed. Mater. PD JAN PY 2016 VL 53 BP 142 EP 150 DI 10.1016/j.jmbbm.2015.08.016 PG 9 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA CY2GJ UT WOS:000366226500013 PM 26318574 ER PT J AU Julian, DW Hickey, JT Fields, WL Ostadrahimi, L Maher, KM Barker, TG Hatfield, CL Lutz, K Marks, CO Sandoval-Solis, S Lund, JR AF Julian, David W. Hickey, John T. Fields, Woodrow L. Ostadrahimi, Leila Maher, Katherine M. Barker, Townsend G. Hatfield, Christopher L. Lutz, Kim Marks, Christian O. Sandoval-Solis, Samuel Lund, Jay R. TI Decision Support System for Water and Environmental Resources in the Connecticut River Basin SO JOURNAL OF WATER RESOURCES PLANNING AND MANAGEMENT LA English DT Article DE Natural flow regime; Environmental flows; Reservoir management; Floodplain forest inundation; Hydrologic alteration; Hydropower; Flood control ID HYDROLOGIC ALTERATION; FLOODPLAIN FOREST; FLOWS; MODEL; MANAGEMENT; RESERVOIR; HABITAT; STREAM; RESTORATION; COMMUNITIES AB This paper describes the development and application of a reservoir management decision support system for evaluating flood-plain benefits and socioeconomic trade-offs of reservoir management alternatives in the Connecticut River watershed. The decision support system is composed of a reservoir system simulation model, an ecological model, and two river hydraulics models. The reservoir model simulated current operations at 73 reservoirs and flows at locations of interest in the Connecticut River watershed. Regulated flows from the reservoir model were compared with unregulated flows, both statistically and spatially, for a suite of environmental flow metrics based on inundation patterns related to floodplain vegetation communities. Analyses demonstrate use of the decision support system and show how its use illuminates (1) trends in existing hydrologic alteration for the Connecticut River mainstem and one of its tributaries, the Farmington River, and (2) management scenarios that might have ecological benefits for floodplain plant communities. The decision support system was used to test two management scenarios to assess potential floodplain benefits and associated trade-offs in hydropower generation and flood risk. The process described shows the usefulness of large-scale reservoir management decision support systems that incorporate environmental considerations in assisting with watershed planning and environmental flow implementation. (C) 2015 American Society of Civil Engineers. C1 [Julian, David W.] Univ Calif Davis, Dept Civil & Environm Engn, Davis, CA 95616 USA. [Hickey, John T.; Fields, Woodrow L.; Ostadrahimi, Leila] US Army Corps Engineers, Hydrol Engn Ctr, Davis, CA 95616 USA. [Maher, Katherine M.] GEI Consultants Inc, Rancho Cordova, CA 95670 USA. [Barker, Townsend G.] US Army Corps Engineers, New England Dist, Water Management Sect, Concord, MA 01742 USA. [Hatfield, Christopher L.] US Army Corps Engineers, New England Dist, Planning Branch, Concord, MA 01742 USA. [Lutz, Kim] Nature Conservancy, Northampton, MA 01060 USA. [Marks, Christian O.] Nature Conservancy, Connecticut River Program, Northampton, MA 01060 USA. [Sandoval-Solis, Samuel] Univ Calif Davis, Dept Land Air & Water Resources, Davis, CA 95616 USA. [Lund, Jay R.] Univ Calif Davis, Civil & Environm Engn, Davis, CA 95616 USA. RP Julian, DW (reprint author), CH2M Hill,2485 Natomas Pk Dr, Sacramento, CA 95833 USA. EM david.julian@ch2m.com; John.Hickey@usace.army.mil; Woodrow.L.Fields@usace.army.mil; Leila.ostadrahimi@usace.army.mil; kmaher@geiconsultants.com; Townsend.g.barker@usace.army.mil; christopher.l.hatfield@usace.army.mil; klutz@tnc.org; cmarks@tnc.org; samsandoval@ucdavis.edu; jrlund@ucdavis.edu NR 74 TC 0 Z9 0 U1 7 U2 26 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9496 EI 1943-5452 J9 J WATER RES PLAN MAN JI J. Water Resour. Plan. Manage.-ASCE PD JAN PY 2016 VL 142 IS 1 AR 04015038 DI 10.1061/(ASCE)WR.1943-5452.0000538 PG 16 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA CY9TW UT WOS:000366750200001 ER PT J AU Burgert, JM Johnson, AD Garcia-Blanco, J Froehle, J Morris, T Althuisius, B Richards, J Castano, C AF Burgert, James M. Johnson, Arthur D. Garcia-Blanco, Jose Froehle, Jacob Morris, Todd Althuisius, Ben Richards, Jennifer Castano, Christopher TI The effects of proximal and distal routes of intraosseous epinephrine administration on short-term resuscitative outcome measures in an adult swine model of ventricular fibrillation: a randomized controlled study SO AMERICAN JOURNAL OF EMERGENCY MEDICINE LA English DT Article ID CARDIOPULMONARY-RESUSCITATION; CARDIAC-ARREST; VASCULAR ACCESS; PHARMACOKINETICS; VASOPRESSIN; INFUSIONS; PIGS AB Introduction: It is unknown if the anatomical distance of intraosseous (IO) epinephrine injection from the heart affects resuscitative outcome. The purpose of this study was to explore the relationships between the anatomical distance of IO epinephrine injection and measures of resuscitative outcome in an adult swine model of ventricular fibrillation (VF). Methods: Thirty-two Yorkshire-cross swine (60-80 kg) were randomly assigned to four groups: humeral IO (HIO), tibial IO (TIO), IV with defibrillation and epinephrine, and IV control: with defibrillation but no epinephrine. Ventricular fibrillation was induced. Swine remained in VF for 4 minutes prior to mechanical chest compressions. After 6 minutes in VF, swine were defibrillated and epinephrine (0.01 mg/kg) administered by group assignment. Defibrillation was repeated every 2 minutes. Epinephrine was repeated every 4 minutes. Interventions continued until return of spontaneous circulation (ROSC) or 26 post-arrest minutes elapsed. Swine achieving ROSC were observed for 30 minutes post-ROSC. Results: There were no significant differences between the HIO, TIO, and IV groups relative to the occurrence of ROSC (P > .05 in all cases), 30-minute post-ROSC survival (P > .05 in all cases), and time to ROSC (P =.43). There were significant differences between the HIO, TIO, and IV groups compared to the control group relative to the occurrence of ROSC (P = .02, .01, and .007 respectively), and 30 minute post-ROSC survival (P =.05, .03, and .007, respectively). Conclusion: The anatomical distance of IO epinephrine injection from the heart did not affect short-term measures of resuscitative outcome in an adult swine model of VF including the occurrence of ROSC, 30 minute post-ROSC survival, and time to ROSC. Rapidly administered epinephrine, irrespective of route of administration, increased the chance ROSC and survival to 30 minutes post-ROSC would occur in this study. Published by Elsevier Inc. C1 [Burgert, James M.; Johnson, Arthur D.; Froehle, Jacob; Morris, Todd; Althuisius, Ben; Richards, Jennifer; Castano, Christopher] Northeastern Univ, US Army Med Dept Ctr & Sch, Houston, TX 78234 USA. [Burgert, James M.; Johnson, Arthur D.; Garcia-Blanco, Jose] Geneva Fdn, Tacoma, WA 98402 USA. RP Burgert, JM (reprint author), Northeastern Univ, US Army Med Dept & Sch, US Army Grad Program Anesthesia Nursing, 3490 Forage Rd,Suite 112, Ft Sam Houston, TX 78234 USA. EM james.burgert@alumni.bcm.edu OI Burgert, James/0000-0001-8346-6196 FU American Association of Nurse Anesthetists Foundation [2014-F-13] FX This work was funded by a postdoctoral fellowship (2014-F-13) granted by the American Association of Nurse Anesthetists Foundation. The funding source had no role in the design of the study; the collection, analysis, and interpretation of the data; writing the report; and the decision to submit the article for publication. NR 26 TC 1 Z9 1 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0735-6757 EI 1532-8171 J9 AM J EMERG MED JI Am. J. Emerg. Med. PD JAN PY 2016 VL 34 IS 1 BP 49 EP 53 DI 10.1016/j.ajem.2015.09.007 PG 5 WC Emergency Medicine SC Emergency Medicine GA CY1IH UT WOS:000366159400010 PM 26462903 ER PT J AU Hogan, JD Farbaniec, L Sano, T Shaeffer, M Ramesh, KT AF Hogan, James David Farbaniec, Lukasz Sano, Tomoko Shaeffer, Matthew Ramesh, K. T. TI The effects of defects on the uniaxial compressive strength and failure of an advanced ceramic SO ACTA MATERIALIA LA English DT Article DE Compressive strength; Defect statistics; Brittle failure; Experimental mechanics; Microstructure design ID PRESSED SILICON-CARBIDE; BORON-CARBIDE; BRITTLE MATERIALS; DYNAMIC STRENGTH; ALUMINUM NITRIDE; BEHAVIOR; FRACTURE; CONFINEMENT; MODEL AB This study investigates the effects of the processing-induced defect population on the dynamic compressive strength and failure of a hot-pressed boron carbide. Quantitative microscopic analysis was used to determine the distributions of three types of processing-induced inhomogeneities: aluminum nitride, small graphitic particles and pores, and larger graphitic disks. Scanning electron microscopy of fracture surfaces identifies the graphitic disks as fracture initiation sites. The size, orientation and number density of the graphitic disks are then quantified using image processing techniques. We use these defect statistics, in conjunction with recent scaling models, to explore our experimentally measured dynamic compressive strength results. (C) 2015 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. C1 [Hogan, James David] Univ Alberta, Dept Mech Engn, Edmonton, AB T6G 2R3, Canada. [Hogan, James David; Farbaniec, Lukasz; Shaeffer, Matthew; Ramesh, K. T.] Johns Hopkins Univ, Hopkins Extreme Mat Inst, Baltimore, MD 21218 USA. [Sano, Tomoko] Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Ramesh, K. T.] Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA. RP Hogan, JD (reprint author), Univ Alberta, Dept Mech Engn, Edmonton, AB T6G 2R3, Canada. EM jdhogan@ualberta.ca OI Hogan, James/0000-0002-9212-9252 FU Army Research Laboratory [W911NF-12-2-0022] FX This research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-12-2-0022. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. Kanak Kuwelkar from Rutgers and Matthew Bratcher from Army Research Laboratories are acknowledged for discussions of the microstructure, Will Wagers, Joe Hajj and Nicole Cade-Ferreira from the Johns Hopkins University are thanked for helping run the experiments. NR 31 TC 6 Z9 6 U1 3 U2 28 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6454 EI 1873-2453 J9 ACTA MATER JI Acta Mater. PD JAN 1 PY 2016 VL 102 BP 263 EP 272 DI 10.1016/j.actamat.2015.09.028 PG 10 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA CX0ED UT WOS:000365368800027 ER PT J AU Shrestha, R Simsiriwong, J Shamsaei, N Moser, RD AF Shrestha, Rakish Simsiriwong, Jutima Shamsaei, Nima Moser, Robert D. TI Cyclic deformation and fatigue behavior of polyether ether ketone (PEEK) SO INTERNATIONAL JOURNAL OF FATIGUE LA English DT Article DE Thermoplastics; Fatigue; Cyclic behavior; Frequency effect; Energy approach ID STRAIN RATES; EPOXY-RESIN; WIDE-RANGE; STRESS; POLYMERS; TEMPERATURES AB In this study, the fatigue behavior of a semi-crystalline thermoplastic polyether ether ketone (PEEK) is investigated. A series of tests at ambient temperature, including uniaxial monotonic (tension and compression) at different strain rates and uniaxial fully-reversed strain-controlled cyclic tests at strain amplitudes ranging from 0.02 mm/mm to 0.04 mm/mm at various frequencies, were conducted. The frequency influence on the strain-controlled fatigue lives of unfilled PEEK specimens was found to be highly dependent on the strain level. A minimal frequency effect was observed at a lower strain amplitude of 0.02 mm/mm, whereas increasing the test frequency at higher strain amplitudes resulted in longer fatigue lives. Additionally, load-controlled cyclic tests that utilized applied loads corresponding to stress responses obtained from the strain-controlled fatigue tests were performed. The cyclic behavior under the two control modes were compared and discussed. Three types of fatigue models, including a strain-based (Coffin-Manson) model, a strain-stress-based (Smith-Watson-Topper) model, and an energy-based model, were employed to correlate the data in this study. Among the three fatigue models, the energy approach was found to better correlate the PEEK experimental data at various frequencies. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Shrestha, Rakish; Shamsaei, Nima] Mississippi State Univ, Dept Mech Engn, Mississippi State, MS 39762 USA. [Simsiriwong, Jutima; Shamsaei, Nima] Mississippi State Univ, CAVS, Mississippi State, MS 39762 USA. [Moser, Robert D.] US Army, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Shamsaei, N (reprint author), Mississippi State Univ, Dept Mech Engn, Box 9552, Mississippi State, MS 39762 USA. EM shamsaei@me.msstate.edu FU U.S. Government [W15QKN-13-9-0001] FX This effort was sponsored by the U.S. Government under Other Transaction no. W15QKN-13-9-0001 between the Consortium for Energy, Environment and Demilitarization, and the Government. The U.S. Government is authorized to reproduce and distribute reprints for Governmental purposes notwithstanding any copyright notation thereon. The views and conclusions contained herein are those of the authors and should not be interpreted as necessarily representing the official policies or endorsements, either expressed or implied, of the U.S. Government. NR 34 TC 6 Z9 6 U1 4 U2 19 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0142-1123 EI 1879-3452 J9 INT J FATIGUE JI Int. J. Fatigue PD JAN PY 2016 VL 82 BP 411 EP 427 DI 10.1016/j.ijfatigue.2015.08.022 PN 3 PG 17 WC Engineering, Mechanical; Materials Science, Multidisciplinary SC Engineering; Materials Science GA CX0DC UT WOS:000365366100006 ER PT J AU Shen, J Kondoh, K Jones, TL Mathaudhu, SN Kecskes, LJ Wei, Q AF Shen, J. Kondoh, K. Jones, T. L. Mathaudhu, S. N. Kecskes, L. J. Wei, Q. TI Effect of strain rate on the mechanical properties of magnesium alloy AMX602 SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE Magnesium alloy; Strengthening mechanisms; Adiabatic shear band; Strain rate effect ID METAL-MATRIX COMPOSITES; SOLIDIFICATION POWDER-METALLURGY; HALL-PETCH RELATION; ROOM-TEMPERATURE; MG ALLOY; PLASTIC-DEFORMATION; TEXTURE EVOLUTION; GRAIN-REFINEMENT; PURE MAGNESIUM; NONBASAL SLIP AB In the present work, the effect of strain rate on the mechanical properties, particularly the plastic deformation behavior of a magnesium alloy, AMX602 (Mg-6%Al-0.5%Mn-2%Ca; all wt%), fabricated by powder metallurgy, has been investigated under both quasi-static (strain rate 1 x 10(-3) s(-1)) and dynamic (strain rate 4 x 10(3) s(-1)) compressive loading. The alloyed powder was extruded at three different temperatures. The microstructure of the alloy was examined by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). It was found that AMX602 exhibits an impressive mechanical behavior but with a slight anisotropy along different directions in both strength and compressive ductility (or malleability). The strength was found to be nearly independent of the extrusion temperature, particularly, under dynamic loading. Nanoindentation strain rate jump test reveals a strain rate sensitivity of similar to 0.018 to similar to 0.015, depending on the extrusion temperature. Sub-micrometer-scale particles of the intermetallic compound Al2Ca were found with sizes ranging from similar to 100 nm to similar to 1.0 mu m. These intermetallic particles are believed to have precipitated out during the extrusion process. They contribute to the formation of the ultrafine equiaxed grains which, in turn, help to improve the strength of the alloy by acting as barriers to dislocation motion. Adiabatic shear bands (ASBs) were observed in the dynamically loaded samples, the propagation of which eventually leads to final fracture of the specimens. (C) 2015 Elsevier B.V. All rights reserved. C1 [Shen, J.; Wei, Q.] Univ N Carolina, Dept Mech Engn, Charlotte, NC 28223 USA. [Kondoh, K.] Osaka Univ, Joining & Welding Res Inst, Osaka 5670047, Japan. [Jones, T. L.; Kecskes, L. J.] US Army Res Lab, WMRD, Aberdeen Proving Ground, MD 21005 USA. [Mathaudhu, S. N.] Univ Calif Riverside, Dept Mech Engn, Riverside, CA 92521 USA. RP Wei, Q (reprint author), Univ N Carolina, Dept Mech Engn, Charlotte, NC 28223 USA. EM qwei@uncc.edu RI Wei, Qiuming/B-7579-2008; Shen, Jianghua/C-2586-2013 OI Shen, Jianghua/0000-0003-1017-0698 FU US Army Research Laboratory [W911QX-08-0073, W911NF-14-2-0061]; China Scholarship Council, National Natural Science Foundation of China [10932008]; 111 Project [B07050] FX This work is supported by US Army Research Laboratory under Contract nos. W911QX-08-0073 and W911NF-14-2-0061. J. H. Shen would like to acknowledge the financial support from China Scholarship Council, National Natural Science Foundation of China (No. 10932008) and the 111 Project (No. B07050). NR 73 TC 3 Z9 3 U1 14 U2 49 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 EI 1873-4936 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD JAN 1 PY 2016 VL 649 BP 338 EP 348 DI 10.1016/j.msea.2015.10.022 PG 11 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA CW2BP UT WOS:000364796400040 ER PT J AU Williams, D AF Williams, Daniel TI CRACKING THE CODE ON THE "HIDDEN CURRICULUM" IN THE MEDICAL EDUCATION PIPELINE AND ITS CONTRIBUTION TO ATTRITION SO Journal of Unschooling and Alternative Learning LA English DT Article DE Premed syndrome; medical school attrition; physician satisfaction; workforce; malignant residency programs ID STUDENTS PERCEPTIONS; SELF-ASSESSMENT; SCHOOL; PHYSICIANS; SATISFACTION; PERFORMANCE; RESIDENTS; BURNOUT; CAREER; PROFESSIONALISM AB Physicians withstand one of the longest and most complicated educational processes in existence. There are a multitude of personal and professional developmental steps along the way that contribute to physician burnout and career dissatisfaction. This article is the first attempt of its kind to conceptualize these various influences into a series of five phases that each physician-in-training experiences, beginning before medical school even starts. The five phases are: 1. The Pre-Med Syndrome, 2. Adaptation, 3. Assimilation, 4. The Let Down, and 5. Reemerging Priorities. Three of the five phases described here can negatively influence the physician's psychological well-being, while two of the phases are quite positive and encouraging. The phases don't necessarily have to occur in sequential order and may be repeated cyclically within each of the formal academic steps (i.e., undergraduate, basic science years of medical school, and the clinical science years). Hopefully, this perspective paper will contribute further to the active discussion of how to make medical education more effective and palatable. C1 [Williams, Daniel] East Texas Med Ctr Behav Hlth Ctr, Tyler, TX USA. RP Williams, D (reprint author), US Army Natl Guard, Montgomery, AL 36109 USA. EM drdanielwilliams@gmail.com NR 60 TC 0 Z9 0 U1 4 U2 12 PU NIPISSING UNIV PI NORTH BAY PA 100 COLLEGE DR, PO BOX 5002, NORTH BAY, ON P1B 8L7, CANADA SN 1916-8128 J9 J UNSCH ALTERN LEARN JI J. Unsch. Altern. Learn. PY 2016 VL 10 IS 19 BP 82 EP 99 PG 18 WC Education & Educational Research SC Education & Educational Research GA CU8HV UT WOS:000363783500004 ER PT J AU Brown, TN O'Donovan, M Hasselquist, L Corner, B Schiffman, JM AF Brown, T. N. O'Donovan, M. Hasselquist, L. Corner, B. Schiffman, J. M. TI Lower limb flexion posture relates to energy absorption during drop landings with soldier-relevant body borne loads SO APPLIED ERGONOMICS LA English DT Article DE Kinematics; Kinetics; Energy absorption; Impact force ID LOWER-EXTREMITY BIOMECHANICS; CRUCIATE LIGAMENT INJURY; JOINT COORDINATE SYSTEM; GROUND REACTION FORCES; SINGLE-LEG LANDINGS; IMPACT FORCES; 3 HEIGHTS; KINEMATICS; KINETICS; EPIDEMIOLOGY AB military personnel performed 30-cm drop landings to quantify how body borne load (light, similar to 6 kg, medium, similar to 20 kg, and heavy, similar to 40 kg) impacts lower limb kinematics and knee joint energy absorption during landing, and determine whether greater lower limb flexion increases energy absorption while landing with load. Participants decreased peak hip (P = 0.002), and knee flexion (P = 0.007) posture, but did not increase hip (P = 0.796), knee (P = 0.427) or ankle (P = 0.161) energy absorption, despite exhibiting greater peak hip (P = 0.003) and knee (P = 0.001) flexion, and ankle (P = 0.003) dorsiflexion angular impulse when landing with additional load. Yet, when landing with the light and medium loads, greater hip (R-2 = 0.500, P = 0.003 and R-2 = 0.314, P = 0.030) and knee (R-2 = 0.431, P = 0.008 and R-2 = 0.342, P = 0.022) flexion posture predicted larger knee joint energy absorption. Thus, military training that promotes hip and knee flexion, and subsequently greater energy absorption during landing, may potentially reduce risk of musculoskeletal injury and optimize soldier performance. Published by Elsevier Ltd. C1 [Brown, T. N.] ORISE, Belcamp, MD USA. [Brown, T. N.; O'Donovan, M.; Hasselquist, L.; Corner, B.; Schiffman, J. M.] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA USA. [Schiffman, J. M.] Liberty Mutual Res Inst Safety, Hopkinton, MA USA. RP Brown, TN (reprint author), Natick Soldier RD & E Ctr, Dept Army, 15 Kansas St, Natick, MA 01760 USA. EM tyler.n.brown4.civ@mail.mil FU Department of the Army, Office of the Assistant Secretary of the Army - Acquisition Logistics and Technology FX This work was supported by an FY 12 Competitive In-house Laboratory Independent Research (ILIR) Award program from the Department of the Army, Office of the Assistant Secretary of the Army - Acquisition Logistics and Technology. The authors thank Ms. Marina Carboni and Mr. Albert Adams for their assistance with this study. NR 41 TC 2 Z9 2 U1 4 U2 27 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0003-6870 EI 1872-9126 J9 APPL ERGON JI Appl. Ergon. PD JAN PY 2016 VL 52 BP 54 EP 61 DI 10.1016/j.apergo.2015.06.004 PG 8 WC Engineering, Industrial; Ergonomics; Psychology, Applied SC Engineering; Psychology GA CS5QQ UT WOS:000362133400007 PM 26360194 ER PT J AU Marayati, BF Schal, C Ponnusamy, L Apperson, CS Rowland, TE Wasserberg, G AF Marayati, Bahjat Fadi Schal, Coby Ponnusamy, Loganathan Apperson, Charles S. Rowland, Tobin E. Wasserberg, Gideon TI Attraction and oviposition preferences of Phlebotomus papatasi (Diptera: Psychodidae), vector of Old-World cutaneous leishmaniasis, to larval rearing media SO PARASITES & VECTORS LA English DT Article DE Leishmaniasis; Oviposition behavior; Sand flies; Semiochemicals; Bioassay; Olfactometer ID SANDFLY LUTZOMYIA-LONGIPALPIS; CHEMICAL ECOLOGY; CONSPECIFIC EGGS; BREEDING SITES; FLIES; IDENTIFICATION; PHEROMONE; BIOLOGY AB Background: As part of a project aimed at developing oviposition attractants for the control and surveillance of Phlebotomus papatasi (a vector of Old-World cutaneous leishmaniasis), we tested the hypothesis that gravid sand flies are attracted to chemical cues emanating from the growth medium of conspecific larvae - predominantly larvae-conditioned host feces that represents a suitable oviposition site. We report the results of a systematic assessment of media from various developmental stages of the sand fly using oviposition and olfactometer behavioral assays. Methods: We conducted multiple-choice oviposition assays in 500 mL Nalgene jars. Six treatments were placed on separate filter paper discs at the bottom of the jar: 2nd/3rd larval instar medium, 4th larval instar/pupae medium, frass from expired colonies, larval food (aged rabbit chow and rabbit feces mix), rabbit feces, and a solvent (water) control. Fifty gravid females were introduced into each jar. Cumulative number of eggs laid on each filter paper per jar was counted at different time intervals from digital images. Attraction of gravid sand flies to these six treatments was assayed with a 3-chamber linear olfactometer. Twenty gravid females were transferred to the middle chamber of the olfactometer and their distribution in treatment and control chambers was recorded after 3 h. Results: Almost no eggs were oviposited during the first 72 h following a blood-meal. Cumulative egg deposition increased drastically in the next 24 h (hours 73-96), with a slight non-significant increasing trend thereafter. Comparing mean cumulative egg deposition among the six treatments, we found that significantly more eggs were oviposited on 2nd/3rd larval rearing medium followed by 4th instar/pupae rearing medium. Oviposition preference did not vary over time. The olfactometer results were consistent with the oviposition assays, with 2nd/3rd larval rearing medium being the most attractive, followed by 4th instar/pupae rearing medium. Conclusion: The key finding of this study is that gravid, laboratory reared, Ph. papatasi sand flies are significantly more attracted to rearing medium of the most biologically active larval stages (2nd/3rd instar and 4th instar/pupae). This finding indicates that sand fly-digested host food and feces is attractive to gravid females and suggests that the larvae and larval gut microbiome may be involved in conditioning the oviposition substrate and possibly the production of oviposition attractants and stimulants. C1 [Marayati, Bahjat Fadi; Wasserberg, Gideon] Univ N Carolina, Dept Biol, Greensboro, NC 27402 USA. [Schal, Coby; Ponnusamy, Loganathan; Apperson, Charles S.] N Carolina State Univ, Dept Entomol, Raleigh, NC 27695 USA. [Rowland, Tobin E.] Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD 20910 USA. RP Wasserberg, G (reprint author), Univ N Carolina, Dept Biol, 235 Eberhart Bldg, Greensboro, NC 27402 USA. EM g_wasser@uncg.edu RI Schal, Coby/A-8717-2010 OI Schal, Coby/0000-0001-7195-6358 FU North Carolina Biotechnology Center Multidisciplinary Research Grant (MRG) [1104]; NIAID FX We thank Edgar D. Rowton for helpful advice and discussions. This research was supported by the North Carolina Biotechnology Center Multidisciplinary Research Grant (MRG) number 1104. We thank NIAID funded BEI Resources Repository for providing resources for obtaining additional sand fly pots. NR 42 TC 0 Z9 0 U1 0 U2 6 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1756-3305 J9 PARASITE VECTOR JI Parasites Vectors PD DEC 30 PY 2015 VL 8 AR 663 DI 10.1186/s13071-015-1261-z PG 9 WC Parasitology SC Parasitology GA CZ8BU UT WOS:000367325800002 PM 26714743 ER PT J AU Wilkerson, RC Linton, YM AF Wilkerson, Richard C. Linton, Yvonne-Marie TI Elevation of Pseudoskusea, Rusticoidus and Protomacleaya to valid subgenera in the mosquito genus Aedes based on taxon naming criteria recently applied to other members of the Tribe Aedini (Diptera: Culicidae) SO PARASITES & VECTORS LA English DT Article DE Tribe Aedini; Aedes; Subgenera; Elevation ID LIFE STAGES; MORPHOLOGICAL DATA; CLASSIFICATION; PHYLOGENY; OCHLEROTATUS AB Background: Pseudoskusea, Rusticoidus and Protomacleaya were well-recognized, morphologically distinct subgenera within the genus Aedes prior to a series of taxonomic changes over the past 15 years by Reinert, Harbach and Kitching, when they were recognized as subgenera of the genus Ochlerotatus. In our recent effort to stabilize the Tribe Aedini, we synonymized these subgenera and associated species back into the genus Aedes, but incorrectly assigned them as putative informal groups, instead of reinstating them to subgenera. Conclusion: Here we formally elevate three traditionally recognized subgenera (Pseudoskusea, Rusticoidus and Protomacleaya) within the genus Aedes. C1 [Wilkerson, Richard C.; Linton, Yvonne-Marie] Smithsonian Inst, Natl Museum Nat Hist, Dept Entomol, Washington, DC 20560 USA. [Linton, Yvonne-Marie] Smithsonian Inst, Walter Reed Biosystemat Unit, Museum Support Ctr, Suitland, MD USA. [Linton, Yvonne-Marie] Walter Reed Army Inst Res, Dept Entomol, Silver Spring, MD USA. [Linton, Yvonne-Marie] Uniformed Serv Univ Hlth Sci, Fac Preventat Med & Biometr, Bethesda, MD 20814 USA. RP Wilkerson, RC (reprint author), Smithsonian Inst, Natl Museum Nat Hist, Dept Entomol, Washington, DC 20560 USA. EM wilkersonr@si.edu FU National Research Council (NRC) FX We thank Bruce Harrison for careful review of the manuscript and his many helpful comments. This research was performed under a Memorandum of Understanding between the Walter Reed Army Institute of Research and the Smithsonian Institution, with institutional support provided by both organizations. This manuscript was prepared whilst YML held a National Research Council (NRC) Research Associateship Award at the Walter Reed Army Institute of Research. The material to be published reflects the views of the authors and should not be construed to represent those of the U.S. Department of the Army or the U.S. Department of Defense. NR 29 TC 1 Z9 1 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1756-3305 J9 PARASITE VECTOR JI Parasites Vectors PD DEC 30 PY 2015 VL 8 AR 668 DI 10.1186/s13071-015-1247-x PG 4 WC Parasitology SC Parasitology GA CZ8BY UT WOS:000367326200002 PM 26714624 ER PT J AU Gordon, SM Lawhern, V Passaro, AD McDowell, K AF Gordon, S. M. Lawhern, V. Passaro, A. D. McDowell, K. TI Informed decomposition of electroencephalographic data SO JOURNAL OF NEUROSCIENCE METHODS LA English DT Article DE Independent components analysis; EEG; Independent subspace analysis; Informed source separation ID INDEPENDENT COMPONENT ANALYSIS; BLIND SOURCE SEPARATION; MUSCLE ARTIFACT REMOVAL; CONSTRAINED ICA; SLEEP EEG; INFORMATION; ALGORITHMS; IMPROVE; SIGNALS; TOOL AB Background: Blind source separation techniques have become the de facto standard for decomposing electroencephalographic (EEG) data. These methods are poorly suited for incorporating prior information into the decomposition process. While alternative techniques to this problem, such as the use of constrained optimization techniques, have been proposed, these alternative techniques tend to only minimally satisfy the prior constraints. In addition, the experimenter must preset a number of parameters describing both this minimal limit as well as the size of the target subspaces. New method: We propose an informed decomposition approach that builds upon the constrained optimization approaches for independent components analysis to better model and separate distinct subspaces within EEG data. We use a likelihood function to adaptively determine the optimal model size for each target subspace. Results: Using our method we are able to produce ordered independent subspaces that exhibit less residual mixing than those obtained with other methods. The results show an improvement in modeling specific features of the EEG space, while also showing a simultaneous reduction in the number of components needed for each model. Comparison with existing method(s): We first compare our approach to common methods in the field of EEG decomposition, such as Infomax, FastICA, PCA, JADE, and SOBI for the task of modeling and removing both EOG and EMG artifacts. We then demonstrate the utility of our approach for the more complex problem of modeling neural activity. Conclusions: By working in a one-size-fits-all fashion current EEG decomposition methods do not adapt to the specifics of each data set and are not well designed to incorporate additional information about the decomposition problem. However, by adding specific information about the problem to the decomposition task, we improve the identification and separation of distinct subspaces within the original data and show better preservation of the remaining data. (C) 2015 The Authors. Published by Elsevier B.V. C1 [Gordon, S. M.; Passaro, A. D.] DCS Corp, Alexandria, VA 22310 USA. [Lawhern, V.; McDowell, K.] US Army Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Gordon, SM (reprint author), DCS Corp, Alexandria, VA 22310 USA. EM sgordon@dcscorp.com FU Army Research Laboratory [W911NF-10-2-0022] FX The authors would like to thank Dr. Kelvin Oie of the Army Research Laboratory and Dr. Jason Metcalfe of DCS Corporation for helpful discussions and directions with respect to the experimental design. The authors would also like to thank Dr. Piotr Franaszczuk of the Army Research Laboratory for his overall guidance and instruction. This research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-10-2-0022. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 61 TC 3 Z9 3 U1 2 U2 15 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-0270 EI 1872-678X J9 J NEUROSCI METH JI J. Neurosci. Methods PD DEC 30 PY 2015 VL 256 BP 41 EP 55 DI 10.1016/j.jneumeth.2015.08.019 PG 15 WC Biochemical Research Methods; Neurosciences SC Biochemistry & Molecular Biology; Neurosciences & Neurology GA CY7VW UT WOS:000366618400005 PM 26306657 ER PT J AU Wallqvist, A Memisevic, V Zavaljevski, N Pieper, R Rajagopala, SV Kwon, K Yu, CG Hoover, TA Reifman, J AF Wallqvist, Anders Memisevic, Vesna Zavaljevski, Nela Pieper, Rembert Rajagopala, Seesandra V. Kwon, Keehwan Yu, Chenggang Hoover, Timothy A. Reifman, Jaques TI Using host-pathogen protein interactions to identify and characterize Francisella tularensis virulence factors SO BMC GENOMICS LA English DT Article DE Host-pathogen interactions; Protein-protein interactions; Francisella tularensis; Intracellular pathogen; Virulence factors ID INTRACELLULAR SURVIVAL; INTERACTION NETWORK; OXIDATIVE STRESS; DATABASE; GROWTH; IDENTIFICATION; MACROPHAGES; SECRETION; GENES; DETERMINANTS AB Background: Francisella tularensis is a select bio-threat agent and one of the most virulent intracellular pathogens known, requiring just a few organisms to establish an infection. Although several virulence factors are known, we lack an understanding of virulence factors that act through host-pathogen protein interactions to promote infection. To address these issues in the highly infectious F. tularensis subsp. tularensis Schu S4 strain, we deployed a combined in silico, in vitro, and in vivo analysis to identify virulence factors and their interactions with host proteins to characterize bacterial infection mechanisms. Results: We initially used comparative genomics and literature to identify and select a set of 49 putative and known virulence factors for analysis. Each protein was then subjected to proteome-scale yeast two-hybrid (Y2H) screens with human and murine cDNA libraries to identify potential host-pathogen protein-protein interactions. Based on the bacterial protein interaction profile with both hosts, we selected seven novel putative virulence factors for mutant construction and animal validation experiments. We were able to create five transposon insertion mutants and used them in an intranasal BALB/c mouse challenge model to establish 50 % lethal dose estimates. Three of these, Delta FTT0482c, Delta FTT1538c, and Delta FTT1597, showed attenuation in lethality and can thus be considered novel F. tularensis virulence factors. The analysis of the accompanying Y2H data identified intracellular protein trafficking between the early endosome to the late endosome as an important component in virulence attenuation for these virulence factors. Furthermore, we also used the Y2H data to investigate host protein binding of two known virulence factors, showing that direct protein binding was a component in the modulation of the inflammatory response via activation of mitogen-activated protein kinases and in the oxidative stress response. Conclusions: Direct interactions with specific host proteins and the ability to influence interactions among host proteins are important components for F. tularensis to avoid host-cell defense mechanisms and successfully establish an infection. Although direct host-pathogen protein-protein binding is only one aspect of Francisella virulence, it is a critical component in directly manipulating and interfering with cellular processes in the host cell. C1 [Wallqvist, Anders; Memisevic, Vesna; Zavaljevski, Nela; Yu, Chenggang; Reifman, Jaques] US Army Med Res & Mat Command, Dept Def Biotechnol, High Performance Comp Software Applicat Inst, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. [Pieper, Rembert; Rajagopala, Seesandra V.; Kwon, Keehwan] J Craig Venter Inst, Rockville, MD 20850 USA. [Hoover, Timothy A.] US Army Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. RP Reifman, J (reprint author), US Army Med Res & Mat Command, Dept Def Biotechnol, High Performance Comp Software Applicat Inst, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. EM jaques.reifman.civ@mail.mil OI wallqvist, anders/0000-0002-9775-7469; Rajagopala, Seesandra/0000-0001-7176-5770 FU U.S. Defense Threat Reduction Agency Award [CBS.MEDBIO.02.10.BH.021]; U.S. Army Medical Research and Materiel Command (Ft. Detrick, MD) as part of the U.S. Army's Network Science Initiative FX This work was supported by U.S. Defense Threat Reduction Agency Award CBS. MEDBIO.02.10.BH.021 and by the U.S. Army Medical Research and Materiel Command (Ft. Detrick, MD) as part of the U.S. Army's Network Science Initiative. The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U.S. Army or the U.S. Department of Defense. This paper has been approved for public release with unlimited distribution. NR 77 TC 1 Z9 1 U1 3 U2 6 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2164 J9 BMC GENOMICS JI BMC Genomics PD DEC 29 PY 2015 VL 16 AR 1106 DI 10.1186/s12864-015-2351-1 PG 18 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA DM1GK UT WOS:000376093200001 PM 26714771 ER PT J AU Kilianski, A Carcel, P Yao, SJ Roth, P Schulte, J Donarum, GB Fochler, ET Hill, JM Liem, AT Wiley, MR Ladner, JT Pfeffer, BP Elliot, O Petrosov, A Jima, DD Vallard, TG Melendrez, MC Skowronski, E Quan, PL Lipkin, WI Gibbons, HS Hirschberg, DL Palacios, GF Rosenzweig, CN AF Kilianski, Andy Carcel, Patrick Yao, Shijie Roth, Pierce Schulte, Josh Donarum, Greg B. Fochler, Ed T. Hill, Jessica M. Liem, Alvin T. Wiley, Michael R. Ladner, Jason T. Pfeffer, Bradley P. Elliot, Oliver Petrosov, Alexandra Jima, Dereje D. Vallard, Tyghe G. Melendrez, Melanie C. Skowronski, Evan Quan, Phenix-Lan Lipkin, W. Ian Gibbons, Henry S. Hirschberg, David L. Palacios, Gustavo F. Rosenzweig, C. Nicole TI Pathosphere.org: pathogen detection and characterization through a web-based, open source informatics platform SO BMC BIOINFORMATICS LA English DT Article ID UNASSEMBLED SEQUENCING DATA; EBOLA-VIRUS; CLINICAL-SAMPLES; GENOMIC ANALYSIS; IDENTIFICATION; DISCOVERY; SURVEILLANCE; STRAIN; CHALLENGES; ALIGNMENT AB Background: The detection of pathogens in complex sample backgrounds has been revolutionized by wide access to next-generation sequencing (NGS) platforms. However, analytical methods to support NGS platforms are not as uniformly available. Pathosphere (found at Pathosphere.org) is a cloud based open sourced community tool that allows for communication, collaboration and sharing of NGS analytical tools and data amongst scientists working in academia, industry and government. The architecture allows for users to upload data and run available bioinformatics pipelines without the need for onsite processing hardware or technical support. Results: The pathogen detection capabilities hosted on Pathosphere were tested by analyzing pathogen-containing samples sequenced by NGS with both spiked human samples as well as human and zoonotic host backgrounds. Pathosphere analytical pipelines developed by Edgewood Chemical Biological Center (ECBC) identified spiked pathogens within a common sample analyzed by 454, Ion Torrent, and Illumina sequencing platforms. ECBC pipelines also correctly identified pathogens in human samples containing arenavirus in addition to animal samples containing flavivirus and coronavirus. These analytical methods were limited in the detection of sequences with limited homology to previous annotations within NCBI databases, such as parvovirus. Utilizing the pipeline-hosting adaptability of Pathosphere, the analytical suite was supplemented by analytical pipelines designed by the United States Army Medical Research Insititute of Infectious Diseases and Walter Reed Army Institute of Research (USAMRIID-WRAIR). These pipelines were implemented and detected parvovirus sequence in the sample that the ECBC iterative analysis previously failed to identify. Conclusions: By accurately detecting pathogens in a variety of samples, this work demonstrates the utility of Pathosphere and provides a platform for utilizing, modifying and creating pipelines for a variety of NGS technologies developed to detect pathogens in complex sample backgrounds. These results serve as an exhibition for the existing pipelines and web-based interface of Pathosphere as well as the plug-in adaptability that allows for integration of newer NGS analytical software as it becomes available. C1 [Kilianski, Andy; Roth, Pierce; Hill, Jessica M.; Liem, Alvin T.; Gibbons, Henry S.; Rosenzweig, C. Nicole] Edgewood Chem & Biol Ctr, Biosci Div, Aberdeen Proving Ground, MD 21010 USA. [Carcel, Patrick; Yao, Shijie; Roth, Pierce; Schulte, Josh; Donarum, Greg B.; Fochler, Ed T.; Hill, Jessica M.; Liem, Alvin T.] OptiMetrics Inc, Abingdon, MD USA. [Wiley, Michael R.; Ladner, Jason T.; Pfeffer, Bradley P.; Palacios, Gustavo F.] US Med Res Inst Infect Dis, Ctr Genome Sci, Frederick, MD USA. [Elliot, Oliver] Columbia Univ, Dept Biomed Informat, New York, NY USA. [Jima, Dereje D.; Vallard, Tyghe G.; Melendrez, Melanie C.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD USA. [Skowronski, Evan] TMG Biosci LLC, Austin, TX USA. [Petrosov, Alexandra; Quan, Phenix-Lan; Lipkin, W. Ian; Hirschberg, David L.] Columbia Univ, Ctr Infect & Immun, New York, NY USA. [Yao, Shijie] LBNL, Joint Genome Inst, Dept Energy, Berkeley, CA USA. [Hirschberg, David L.] Univ Washington, Dept Interdisciplinary Arts & Sci, Tacoma, WA USA. RP Rosenzweig, CN (reprint author), Edgewood Chem & Biol Ctr, Biosci Div, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM carolyn.n.rosenzweig.civ@mail.mil RI Palacios, Gustavo/I-7773-2015; OI Palacios, Gustavo/0000-0001-5062-1938; Melendrez, Melanie/0000-0002-4811-4467; Kilianski, Andy/0000-0002-2350-0142 FU National Academy of Science FX This work was made possible by the Defense Threat Reduction Agency effort CB3576 to C.N.R and CB2847 to H.S.G and C.N.R. and CB3575 to W.I.L. A.K is supported by the National Academy of Science and DTRA as a National Research Council (NRC) fellow. The authors report no competing interests for this work. Conclusions and opinions presented here are those of the authors and are not the official policy of the US Army, ECBC, or the US Government. Information in this report is cleared for public release and distribution is unlimited. NR 59 TC 3 Z9 3 U1 5 U2 20 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2105 J9 BMC BIOINFORMATICS JI BMC Bioinformatics PD DEC 29 PY 2015 VL 16 AR 416 DI 10.1186/s12859-015-0840-5 PG 12 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Mathematical & Computational Biology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Mathematical & Computational Biology GA CZ6RU UT WOS:000367229200003 PM 26714571 ER PT J AU Izvekov, S Rice, BM AF Izvekov, Sergei Rice, Betsy M. TI A new parameter-free soft-core potential for silica and its application to simulation of silica anomalies SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID MOLECULAR-DYNAMICS SIMULATION; X-RAY-DIFFRACTION; HIGH-PRESSURE; LIQUID SILICA; SUPERCOOLED WATER; FORCE-FIELD; SIO2 GLASS; COMPUTER-SIMULATION; RAMAN-SPECTROSCOPY; ELASTIC PROPERTIES AB A core-softening of the effective interaction between oxygen atoms in water and silica systems and its role in developing anomalous thermodynamic, transport, and structural properties have been extensively debated. For silica, the progress with addressing these issues has been hampered by a lack of effective interaction models with explicit core-softening. In this work, we present an extension of a two-body soft-core interatomic force field for silica recently reported by us [S. Izvekov and B. M. Rice, J. Chem. Phys. 136(13), 134508 (2012)] to include three-body forces. Similar to two-body interaction terms, the three-body terms are derived using parameter-free force-matching of the interactions from ab initio MD simulations of liquid silica. The derived shape of the O-Si-O three-body potential term affirms the existence of repulsion softening between oxygen atoms at short separations. The new model shows a good performance in simulating liquid, amorphous, and crystalline silica. By comparing the soft-core model and a similar model with the soft-core suppressed, we demonstrate that the topology reorganization within the local tetrahedral network and the O-O core-softening are two competitive mechanisms responsible for anomalous thermodynamic and kinetic behaviors observed in liquid and amorphous silica. The studied anomalies include the temperature of density maximum locus and anomalous diffusivity in liquid silica, and irreversible densification of amorphous silica. We show that the O-O core-softened interaction enhances the observed anomalies primarily through two mechanisms: facilitating the defect driven structural rearrangements of the silica tetrahedral network and modifying the tetrahedral ordering induced interactions toward multiple characteristic scales, the feature which underlies the thermodynamic anomalies. C1 [Izvekov, Sergei; Rice, Betsy M.] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Izvekov, S (reprint author), US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM sergiy.izvyekov.civ@mail.mil FU ARL Director's Strategic Initiative "Multi-Scale Modeling of Non-Crystalline Ceramics (Glass)"; DoD High Performance Computing Modernization Program Software Application Institute for Multi-Scale Reactive Modeling of Insensitive Munitions FX The authors wish to thank Dr. George Gazonas, Dr. Ed Byrd, and Dr. Scott Weingarten for helpful discussions. This research was partially supported by the ARL Director's Strategic Initiative "Multi-Scale Modeling of Non-Crystalline Ceramics (Glass)" and the DoD High Performance Computing Modernization Program Software Application Institute for Multi-Scale Reactive Modeling of Insensitive Munitions (2008-2014). NR 152 TC 1 Z9 1 U1 7 U2 25 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-9606 EI 1089-7690 J9 J CHEM PHYS JI J. Chem. Phys. PD DEC 28 PY 2015 VL 143 IS 24 AR 244506 DI 10.1063/1.4937394 PG 18 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA DE1UV UT WOS:000370412900112 PM 26723691 ER PT J AU Sunday, KJ Darling, KA Hanejko, FG Anasori, B Liu, YC Taheri, ML AF Sunday, Katie Jo Darling, Kristopher A. Hanejko, Francis G. Anasori, Babak Liu, Yan-Chun Taheri, Mitra L. TI Al2O3 "self-coated" iron powder composites via mechanical milling SO JOURNAL OF ALLOYS AND COMPOUNDS LA English DT Article DE Composite materials; Powder metallurgy; SEM; Magnetization ID SOFT-MAGNETIC COMPOSITES; ALUMINA; POLYEPOXY; PARTICLES; PHOSPHATE; OXIDATION; SILICA AB Electrically insulated ferrous powders permit isotropic magnetic flux, lower core losses, and structural freedom for state-of-the-art electromagnetic (EM) core and device designs. Many current coating materials are limited by low melting temperatures, which leads to insufficient insulation of powders, resulting in metal-on-metal contact. Use of a high-temperature coating material, such as alumina, could alleviate these issues. In this work, iron powder was mechanically milled with alumina media, to yield plastically deformed, alumina-coated iron particles with improved magnetic saturation, elastic modulus, and hardness. Various milling times and media ball sizes are investigated to maintain particle size, insulate powders uniformly, and optimize properties after compaction and curing. We found that longer milling times yielded more dense powder coatings and lower magnetic saturation. (C) 2015 Elsevier B.V. All rights reserved. C1 [Sunday, Katie Jo; Anasori, Babak; Liu, Yan-Chun; Taheri, Mitra L.] Univ Penn, Dept Mat Sci & Engn, Philadelphia, PA 19104 USA. [Darling, Kristopher A.] US Army Res Lab, Weap & Mat Res Div, Aberdeen, MD 21005 USA. [Hanejko, Francis G.] Hoeganaes Corp, Cinnaminson, NJ 08077 USA. RP Taheri, ML (reprint author), Univ Penn, Dept Mat Sci & Engn, 3231 Walnut St, Philadelphia, PA 19104 USA. EM mtaheri@coe.drexel.edu RI Anasori, Babak/O-4828-2015 OI Anasori, Babak/0000-0002-1955-253X FU National Science Foundation [235672] FX Authors KJS and MLT acknowledge funding from the National Science Foundation under Grant No. 235672. We thank Steve May for access to the vibrating sample magnetometer, Christopher M. Barr and Wayne Harlow for various SEM images, and the Centralized Research Facilities for access to the x-ray diffractometer and scanning electron microscope at Drexel University. NR 36 TC 3 Z9 3 U1 5 U2 34 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0925-8388 EI 1873-4669 J9 J ALLOY COMPD JI J. Alloy. Compd. PD DEC 25 PY 2015 VL 653 BP 61 EP 68 DI 10.1016/j.jallcom.2015.08.260 PG 8 WC Chemistry, Physical; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Chemistry; Materials Science; Metallurgy & Metallurgical Engineering GA CU1GZ UT WOS:000363270000009 ER PT J AU Draper, SJ Angov, E Horii, T Miller, LH Srinivasan, P Theisen, M Biswas, S AF Draper, Simon J. Angov, Evelina Horii, Toshihiro Miller, Louis H. Srinivasan, Prakash Theisen, Michael Biswas, Sumi TI Recent advances in recombinant protein-based malaria vaccines SO VACCINE LA English DT Article DE Malaria; Recombinant protein; Vaccine; Adjuvant; Plasmodium falciparum; Antibody ID BLOOD-STAGE MALARIA; APICAL MEMBRANE ANTIGEN-1; TRANSMISSION-BLOCKING VACCINE; GLUTAMATE-RICH PROTEIN; MEROZOITE SURFACE PROTEIN-3; PLASMODIUM-FALCIPARUM INVASION; HOST-CELL INVASION; NATURALLY ACQUIRED ANTIBODIES; MONTANIDE ISA 51; CLINICAL MALARIA AB Plasmodium parasites are the causative agent of human malaria, and the development of a highly effective vaccine against infection, disease and transmission remains a key priority. It is widely established that multiple stages of the parasite's complex lifecycle within the human host and mosquito vector are susceptible to vaccine-induced antibodies. The mainstay approach to antibody induction by subunit vaccination has been the delivery of protein antigen formulated in adjuvant. Extensive efforts have been made in this endeavor with respect to malaria vaccine development, especially with regard to target antigen discovery, protein expression platforms, adjuvant testing, and development of soluble and virus-like particle (VLP) delivery platforms. The breadth of approaches to protein-based vaccines is continuing to expand as innovative new concepts in next-generation subunit design are explored, with the prospects for the development of a highly effective multi-component/multi-stage/multi-antigen formulation seeming ever more likely. This review will focus on recent progress in protein vaccine design, development and/or clinical testing for a number of leading malaria antigens from the sporozoite-, merozoite- and sexual-stages of the parasite's lifecycle-including PfCeITOS, PfMSP1, PfAMA1, PfRH5, PfSERA5, PfGLURP, PfMSP3, Pfs48/45 and Pfs25. Future prospects and challenges for the development, production, human delivery and assessment of protein-based malaria vaccines are discussed. (C) 2015 The Authors. Published by Elsevier Ltd. C1 [Draper, Simon J.; Biswas, Sumi] Univ Oxford, Jenner Inst, Oxford OX3 7DQ, England. [Angov, Evelina] Walter Reed Army Inst Res, US Mil Malaria Res Program, Silver Spring, MD 20910 USA. [Horii, Toshihiro] Osaka Univ, Microbial Dis Res Inst, Dept Mol Protozool, Suita, Osaka 561873, Japan. [Miller, Louis H.; Srinivasan, Prakash] NIAID, Malaria Cell Biol Sect, Lab Malaria & Vector Res, NIH, Rockville, MD 20852 USA. [Theisen, Michael] Statens Serum Inst, Dept Congenital Disorders, DK-2300 Copenhagen, Denmark. [Theisen, Michael] Univ Copenhagen, Rigshosp, Ctr Med Parasitol, Dept Int Hlth Immunol & Microbiol, DK-2100 Copenhagen, Denmark. [Theisen, Michael] Univ Copenhagen, Rigshosp, Dept Infect Dis, DK-2100 Copenhagen, Denmark. RP Draper, SJ (reprint author), Univ Oxford, Jenner Inst, Old Rd Campus Res Bldg,Roosevelt Dr, Oxford OX3 7DQ, England. EM simon.draper@ndm.ox.ac.uk OI Draper, Simon/0000-0002-9415-1357 FU UK Medical Research Council (MRC) [G1000527]; U.S. Military Infectious Diseases Research Program (MIDRP); U.S. Agency for International Development (USAID) through an Interagency Agreement (IAA); Ministry of Education, Culture, Sports, Science and Technology of Japan [24249024]; Global Health Innovative Technology Fund [GHIT RFP 2013-001]; Intramural Research Program of the Division of Intramtral Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, USA; USAID; EU FP7 Seventh Framework Program Theme [Health-2009-2.3.2-5, 242079]; Danish Council for Strategic research [13127]; European and Developing Countries Clinical Trials Partnership (EDCTP) [IP.2007.3110.001] FX SJD is a Jenner Investigator, a Lister Institute Research Prize Fellow and a UK Medical Research Council (MRC) Career Development Fellow [G1000527; this Fellowship is jointly funded by the UK MRC and the UK Department for International Development (DFID) under the MRC/DFID Concordat agreement]. EA acknowledges funding from the U.S. Military Infectious Diseases Research Program (MIDRP) and the U.S. Agency for International Development (USAID) through an Interagency Agreement (IAA). TH acknowledges funding from Grant-in-Aid for Scientific Research (A) [grant number 24249024] from the Ministry of Education, Culture, Sports, Science and Technology of Japan; and Global Health Innovative Technology Fund [GHIT RFP 2013-001]. LHM and PS are supported by the Intramural Research Program of the Division of Intramtral Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, USA; and also acknowledge support from USAID. MT acknowledges funding from the EU FP7 Seventh Framework Program Theme Health-2009-2.3.2-5 [grant 242079]; the Danish Council for Strategic research [grant 13127]; and the European and Developing Countries Clinical Trials Partnership (EDCTP) [grant IP.2007.3110.001]. SB is a NDM Leadership Fellow and Junior Research Fellow of St Catherine's College, Oxford University. NR 198 TC 11 Z9 11 U1 8 U2 25 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD DEC 22 PY 2015 VL 33 IS 52 SI SI BP 7433 EP 7443 DI 10.1016/j.vaccine.2015.09.093 PG 11 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA DA0MR UT WOS:000367491700003 PM 26458807 ER PT J AU Ouattara, A Barry, AE Dutta, S Remarque, EJ Beeson, JG Plowe, CV AF Ouattara, Amed Barry, Alyssa E. Dutta, Sheetij Remarque, Edmond J. Beeson, James G. Plowe, Christopher V. TI Designing malaria vaccines to circumvent antigen variability SO VACCINE LA English DT Article DE Malaria; Vaccine; Diversity; Heterologous; Allele-specific efficacy; Cross-protection ID APICAL MEMBRANE ANTIGEN-1; PLASMODIUM-FALCIPARUM MALARIA; ALLELE-SPECIFIC EFFICACY; GENETIC DIVERSITY; PREERYTHROCYTIC STAGES; POPULATION-STRUCTURE; REVERSE VACCINOLOGY; SPOROZOITE VACCINE; HUMAN IMMUNITY; IMMUNIZATION AB Prospects for malaria eradication will be greatly enhanced by an effective vaccine, but parasite genetic diversity poses a major impediment to malaria vaccine efficacy. In recent pre-clinical and field trials, vaccines based on polymorphic Plasmodium falciparum antigens have shown efficacy only against homologous strains, raising the specter of allele-specific immunity such as that which plagues vaccines against influenza and HIV. The most advanced malaria vaccine, RTS,S, targets relatively conserved epitopes on the P. falciparum circumsporozoite protein. After more than 40 years of development and testing, RTS,S, has shown significant but modest efficacy against clinical malaria in phase 2 and 3 trials. Ongoing phase 2 studies of an irradiated sporozoite vaccine will ascertain whether the full protection against homologous experimental malaria challenge conferred by high doses of a whole organism vaccine can provide protection against diverse strains in the field. Here we review and evaluate approaches being taken to design broadly cross-protective malaria vaccines. (C) 2015 Published by Elsevier Ltd. C1 [Ouattara, Amed; Plowe, Christopher V.] Univ Maryland, Sch Med, Inst Global Hlth, Baltimore, MD 21201 USA. [Ouattara, Amed; Plowe, Christopher V.] Univ Maryland, Sch Med, Howard Hughes Med Inst, Baltimore, MD 21201 USA. [Ouattara, Amed] Univ Sci Techn & Technol, Malaria Res & Training Ctr, Bamako, Mali. [Barry, Alyssa E.] Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Populat Hlth & Immun, Parkville, Vic 3050, Australia. [Barry, Alyssa E.] Univ Melbourne, Dept Med Biol, Melbourne, Vic, Australia. [Dutta, Sheetij] Walter Reed Army Inst Res, Silver Spring, MD USA. [Remarque, Edmond J.] Biomed Primate Res Ctr, Rijswijk, Netherlands. [Beeson, James G.] Burnet Inst, Melbourne, Vic, Australia. [Beeson, James G.] Monash Univ, Dept Microbiol, Clayton, Vic 3800, Australia. RP Plowe, CV (reprint author), Univ Maryland, Sch Med, 685 West Baltimore St,HSF1-480, Baltimore, MD 21201 USA. EM aouattara@medicine.umaryland.edu; barry@wehi.edu.au; sheetij.dutta.civ@mail.mil; remarque@bprc.nl; beeson@burnet.edu.au; cplowe@medicine.umaryland.edu FU Howard Hughes Medical Institute; National Institute for Allergy and Infectious Diseases, U.S. National Institutes of Health; Victorian State Government; Australian Government NHMRC IRIISS FX AO and CVP are supported by the Howard Hughes Medical Institute and the National Institute for Allergy and Infectious Diseases, U.S. National Institutes of Health. AEB and JB acknowledge the support of the Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS. NR 81 TC 2 Z9 2 U1 4 U2 11 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD DEC 22 PY 2015 VL 33 IS 52 SI SI BP 7506 EP 7512 DI 10.1016/j.vaccine.2015.09.110 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA DA0MR UT WOS:000367491700012 PM 26475447 ER PT J AU Wu, YM Narum, DL Fleury, S Jennings, G Yadava, A AF Wu, Yimin Narum, David L. Fleury, Sylvain Jennings, Gary Yadava, Anjali TI Particle-based platforms for malaria vaccines SO VACCINE LA English DT Article DE Malaria; Vaccine; Particle; Delivery; Adjuvant ID TRANSMISSION-BLOCKING VACCINE; EMULSION-BASED ADJUVANTS; AERUGINOSA EXOPROTEIN-A; IMMUNE-RESPONSES; ANTIBODY-RESPONSE; THERAPEUTIC VACCINES; FALCIPARUM-MALARIA; CONJUGATE VACCINES; RHESUS MACAQUES; EPITOPE DENSITY AB Recombinant subunit vaccines in general are poor immunogens likely due to the small size of peptides and proteins, combined with the lack or reduced presentation of repetitive motifs and missing complementary signal(s) for optimal triggering of the immune response. Therefore, recombinant subunit vaccines require enhancement by vaccine delivery vehicles in order to attain adequate protective immunity. Particle-based delivery platforms, including particulate antigens and particulate adjuvants, are promising delivery vehicles for modifying the way in which immunogens are presented to both the innate and adaptive immune systems. These particle delivery platforms can also co-deliver non-specific immunostimodulators as additional adjuvants. This paper reviews efforts and advances of the Particle-based delivery platforms in development of vaccines against malaria, a disease that claims over 600,000 lives per year, most of them are children under 5 years of age in sub-Sahara Africa. (C) 2015 Elsevier Ltd. C1 [Wu, Yimin; Narum, David L.] NIAID, Lab Malaria Immunol & Vaccinol, Rockville, MD 20892 USA. [Fleury, Sylvain] Mymetics Corp, CH-1066 Epalinges, Switzerland. [Jennings, Gary] Cytos Biotechnol AG, CH-8952 Schlieren, Switzerland. [Yadava, Anjali] Walter Reed Army Inst Res, Malaria Vaccine Branch, US Mil Malaria Vaccine Program, Silver Spring, MD USA. RP Wu, YM (reprint author), PATH Malaria Vaccine Initiat, 455 Massachusetts Ave, Washington, DC 20001 USA. EM ywu@path.org FU Division of Intramural Research, NIAID, NIH FX The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of either the Department of Health and Human Services, the Department of the Army, the Department of Defense or the U.S. Government. YW and DLN are supported by Division of Intramural Research, NIAID, NIH. NR 69 TC 2 Z9 2 U1 3 U2 7 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD DEC 22 PY 2015 VL 33 IS 52 SI SI BP 7518 EP 7524 DI 10.1016/j.vaccine.2015.09.097 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA DA0MR UT WOS:000367491700014 PM 26458803 ER PT J AU Prokop, CJ Crider, BP Liddick, SN Ayangeakaa, AD Carpenter, MP Carroll, JJ Chen, J Chiara, CJ David, HM Dombos, AC Go, S Harker, J Janssens, RVF Larson, N Lauritsen, T Lewis, R Quinn, SJ Recchia, F Seweryniak, D Spyrou, A Suchyta, S Walters, WB Zhu, S AF Prokop, C. J. Crider, B. P. Liddick, S. N. Ayangeakaa, A. D. Carpenter, M. P. Carroll, J. J. Chen, J. Chiara, C. J. David, H. M. Dombos, A. C. Go, S. Harker, J. Janssens, R. V. F. Larson, N. Lauritsen, T. Lewis, R. Quinn, S. J. Recchia, F. Seweryniak, D. Spyrou, A. Suchyta, S. Walters, W. B. Zhu, S. TI New low-energy 0(+) state and shape coexistence in Ni-70 SO PHYSICAL REVIEW C LA English DT Article ID BETA-DECAY; ISOTOPES; NUCLEI; SPECTROSCOPY; ISOMERS; BANDS; ODD AB In recent models, the neutron-rich Ni isotopes around N = 40 are predicted to exhibit multiple low-energy excited 0(+) states attributed to neutron and proton excitations across both the N = 40 and Z = 28 shell gaps. In Ni-68, the three observed 0(+) states have been interpreted in terms of triple shape coexistence between spherical, oblate, and prolate deformed shapes. In the present work a new (0(2)(+)) state at an energy of 1567 keV has been discovered in Ni-70 by using beta-delayed, gamma-ray spectroscopy following the decay of Co-70. The precipitous drop in the energy of the prolate-deformed 0(+) level between Ni-68 and Ni-70 with the addition of two neutrons compares favorably with results of Monte Carlo shell-model calculations carried out in the large fpg(9/2)d(5/2) model space, which predict a 0(2)(+) state at 1525 keV in Ni-70. The result extends the shape-coexistence picture in the region to Ni-70 and confirms the importance of the role of the tensor component of the monopole interaction in describing the structure of neutron-rich nuclei. C1 [Prokop, C. J.; Crider, B. P.; Liddick, S. N.; Chen, J.; Dombos, A. C.; Larson, N.; Lewis, R.; Quinn, S. J.; Spyrou, A.] Michigan State Univ, Natl Supercond Cyclotron Lab, E Lansing, MI 48824 USA. [Prokop, C. J.; Liddick, S. N.; Larson, N.; Lewis, R.] Michigan State Univ, Dept Chem, E Lansing, MI 48824 USA. [Ayangeakaa, A. D.; Carpenter, M. P.; David, H. M.; Harker, J.; Janssens, R. V. F.; Lauritsen, T.; Seweryniak, D.; Zhu, S.] Argonne Natl Lab, Div Phys, Argonne, IL 60439 USA. [Carroll, J. J.] US Army, Res Lab, Adelphi, MD 20783 USA. [Chiara, C. J.] US Army, Res Lab, Oak Ridge Associated Univ Fellowship Program, Adelphi, MD 20783 USA. [Dombos, A. C.; Quinn, S. J.; Spyrou, A.] Michigan State Univ, Dept Phys, E Lansing, MI 48824 USA. [Go, S.] Univ Tennessee, Dept Phys & Astron, Knoxville, TN 37996 USA. [Harker, J.; Walters, W. B.] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA. [Recchia, F.] Univ Padua, Dipartimento Fis & Astron, I-35131 Padua, Italy. [Suchyta, S.] Univ Calif Berkeley, Dept Nucl Engn, Berkeley, CA 94720 USA. RP Prokop, CJ (reprint author), Michigan State Univ, Natl Supercond Cyclotron Lab, E Lansing, MI 48824 USA. EM prokop@nscl.msu.edu RI Larson, Nicole/S-5997-2016 OI Larson, Nicole/0000-0003-0292-957X FU National Science Foundation (NSF) [PHY-1102511]; Department of Energy National Nuclear Security Administration (NNSA) [DE-NA0000979, DE-NA0002132, DE-FG52-08NA28552]; U.S Department of Energy, Office of Science, Office of Nuclear Physics [DE-AC-06CH11357, DE-FG02-94ER40834, DE-FG02-96ER40983]; U.S. Army Research Laboratory [W911NF-12-2-0019] FX This work was supported in part by National Science Foundation (NSF) under contract No. PHY-1102511, by the Department of Energy National Nuclear Security Administration (NNSA) under Awards No. DE-NA0000979, No. DE-NA0002132, and No. DE-FG52-08NA28552, by the U.S Department of Energy, Office of Science, Office of Nuclear Physics, under Contract No. DE-AC-06CH11357 (ANL) and Grants No. DE-FG02-94ER40834 (Maryland) and No. DE-FG02-96ER40983 (UT), and by the U.S. Army Research Laboratory under Cooperative Agreement W911NF-12-2-0019. NR 41 TC 10 Z9 10 U1 2 U2 8 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0556-2813 EI 1089-490X J9 PHYS REV C JI Phys. Rev. C PD DEC 21 PY 2015 VL 92 IS 6 AR 061302 DI 10.1103/PhysRevC.92.061302 PG 6 WC Physics, Nuclear SC Physics GA CZ4IW UT WOS:000367067700001 ER PT J AU Riley, MC Wilkes, RP AF Riley, Matthew C. Wilkes, Rebecca P. TI Sequencing of emerging canine distemper virus strain reveals new distinct genetic lineage in the United States associated with disease in wildlife and domestic canine populations SO VIROLOGY JOURNAL LA English DT Article DE Canine distemper virus; CDV; Genome sequencing; New CDV strain; Phylogenetics; Vaccination; Vaccines ID VACCINATED DOGS; IDENTIFICATION; HEMAGGLUTININ; INFECTION; VIRULENCE; REGION AB Background: Recent outbreaks of canine distemper have prompted examination of strains from clinical samples submitted to the University of Tennessee College of Veterinary Medicine (UTCVM) Clinical Virology Lab. We previously described a new strain of CDV that significantly diverged from all genotypes reported to date including America 2, the genotype proposed to be the main lineage currently circulating in the US. The aim of this study was to determine when this new strain appeared and how widespread it is in animal populations, given that it has also been detected in fully vaccinated adult dogs. Additionally, we sequenced complete viral genomes to characterize the strain and determine if variation is confined to known variable regions of the genome or if the changes are also present in more conserved regions. Methods: Archived clinical samples were genotyped using real-time RT-PCR amplification and sequencing. The genomes of two unrelated viruses from a dog and fox each from a different state were sequenced and aligned with previously published genomes. Phylogenetic analysis was performed using coding, non-coding and genome-length sequences. Virus neutralization assays were used to evaluate potential antigenic differences between this strain and a vaccine strain and mixed ANOVA test was used to compare the titers. Results: Genotyping revealed this strain first appeared in 2011 and was detected in dogs from multiple states in the Southeast region of the United States. It was the main strain detected among the clinical samples that were typed from 2011-2013, including wildlife submissions. Genome sequencing demonstrated that it is highly conserved within a new lineage and preliminary serologic testing showed significant differences in neutralizing antibody titers between this strain and the strain commonly used in vaccines. Conclusion: This new strain represents an emerging CDV in domestic dogs in the US, may be associated with a stable reservoir in the wildlife population, and could facilitate vaccine escape. C1 [Riley, Matthew C.; Wilkes, Rebecca P.] Univ Tennessee, Dept Biomed & Diagnost Sci, Coll Vet Med, Knoxville, TN 37996 USA. [Riley, Matthew C.] US Army, Med Serv Corps, Salt Lake City, UT USA. RP Wilkes, RP (reprint author), Univ Tennessee, Dept Biomed & Diagnost Sci, Coll Vet Med, 2407 River Dr, Knoxville, TN 37996 USA. EM beckpen@uga.edu FU Department of Biomedical and Diagnostic Sciences Education Advancement and Research Fund, College of Veterinary Medicine, The University of Tennessee FX This work was supported by the Department of Biomedical and Diagnostic Sciences Education Advancement and Research Fund, College of Veterinary Medicine, The University of Tennessee. NR 34 TC 2 Z9 2 U1 5 U2 16 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1743-422X J9 VIROL J JI Virol. J. PD DEC 18 PY 2015 VL 12 AR 219 DI 10.1186/s12985-015-0445-7 PG 10 WC Virology SC Virology GA CZ1UF UT WOS:000366890300001 PM 26683832 ER PT J AU Morris, JR Russell, JN Karwacki, CJ AF Morris, John R. Russell, John N., Jr. Karwacki, Christopher J. TI An Operando View of the Nanoscale SO JOURNAL OF PHYSICAL CHEMISTRY LETTERS LA English DT Editorial Material ID SURFACE-CHEMISTRY; CATALYSTS; EVOLUTION; XPS; CO2 C1 [Morris, John R.] Virginia Tech, Dept Chem, Blacksburg, VA 24061 USA. [Russell, John N., Jr.] Naval Res Lab, Div Chem, Washington, DC 20375 USA. [Karwacki, Christopher J.] US Army, Protect & Decontaminat Div, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Karwacki, CJ (reprint author), US Army, Protect & Decontaminat Div, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. EM christopher.j.karwacki.civ@mail.mil NR 24 TC 1 Z9 1 U1 5 U2 25 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1948-7185 J9 J PHYS CHEM LETT JI J. Phys. Chem. Lett. PD DEC 17 PY 2015 VL 6 IS 24 BP 4923 EP 4926 DI 10.1021/acs.jpclett.5b02330 PG 4 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Atomic, Molecular & Chemical SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA CZ1SQ UT WOS:000366886000008 PM 26722703 ER PT J AU Mate, SE Kugelman, JR Nyenswah, TG Ladner, JT Wiley, MR Cordier-Lassalle, T Christie, A Schroth, GP Gross, SM Davies-Wayne, GJ Shinde, SA Murugan, R Sieh, SB Badio, M Fakoli, L Taweh, F de Wit, E van Doremalen, N Munster, VJ Pettitt, J Prieto, K Humrighouse, BW Stroher, U DiClaro, JW Hensley, LE Schoepp, RJ Safronetz, D Fair, J Kuhn, JH Blackley, DJ Laney, AS Williams, DE Lo, T Gasasira, A Nichol, ST Formenty, P Kateh, FN De Cock, KM Bolay, F Sanchez-Lockhart, M Palacios, G AF Mate, S. E. Kugelman, J. R. Nyenswah, T. G. Ladner, J. T. Wiley, M. R. Cordier-Lassalle, T. Christie, A. Schroth, G. P. Gross, S. M. Davies-Wayne, G. J. Shinde, S. A. Murugan, R. Sieh, S. B. Badio, M. Fakoli, L. Taweh, F. de Wit, E. van Doremalen, N. Munster, V. J. Pettitt, J. Prieto, K. Humrighouse, B. W. Stroeher, U. DiClaro, J. W. Hensley, L. E. Schoepp, R. J. Safronetz, D. Fair, J. Kuhn, J. H. Blackley, D. J. Laney, A. S. Williams, D. E. Lo, T. Gasasira, A. Nichol, S. T. Formenty, P. Kateh, F. N. De Cock, K. M. Bolay, F. Sanchez-Lockhart, M. Palacios, G. TI Molecular Evidence of Sexual Transmission of Ebola Virus SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID SIERRA-LEONE; OUTBREAK; LIBERIA; CONGO; PERSISTENCE; EVOLUTION; DISEASE; KIKWIT; GUINEA AB A suspected case of sexual transmission from a male survivor of Ebola virus disease (EVD) to his female partner (the patient in this report) occurred in Liberia in March 2015. Ebola virus (EBOV) genomes assembled from blood samples from the patient and a semen sample from the survivor were consistent with direct transmission. The genomes shared three substitutions that were absent from all other Western African EBOV sequences and that were distinct from the last documented transmission chain in Liberia before this case. Combined with epidemiologic data, the genomic analysis provides evidence of sexual transmission of EBOV and evidence of the persistence of infective EBOV in semen for 179 days or more after the onset of EVD. C1 [Mate, S. E.; Kugelman, J. R.; Ladner, J. T.; Wiley, M. R.; Prieto, K.; Sanchez-Lockhart, M.; Palacios, G.] US Army Med Res Inst Infect Dis, Ctr Genome Sci, Frederick, MD 21702 USA. [Schoepp, R. J.] US Army Med Res Inst Infect Dis, Diagnost Syst Div, Frederick, MD 21702 USA. [Pettitt, J.; Hensley, L. E.; Kuhn, J. H.] NIAID, Div Clin Res, Integrated Res Facil Ft Detrick, NIH, Frederick, MD USA. [Nyenswah, T. G.; Sieh, S. B.; Badio, M.; Kateh, F. N.] Minist Hlth & Social Welf, Monrovia, Liberia. [Davies-Wayne, G. J.; Murugan, R.] WHO, Monrovia, Liberia. [Fakoli, L.; Taweh, F.; Bolay, F.] Liberian Inst Biomed Res, Charlesville, Liberia. [Cordier-Lassalle, T.; Christie, A.; Formenty, P.] WHO, Geneva, Switzerland. [Christie, A.; Humrighouse, B. W.; Stroeher, U.; Blackley, D. J.; Laney, A. S.; Williams, D. E.; Lo, T.; Nichol, S. T.; De Cock, K. M.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Schroth, G. P.; Gross, S. M.] Illumina, San Diego, CA USA. [Shinde, S. A.] WHO, New Delhi, India. [de Wit, E.; van Doremalen, N.; Munster, V. J.; Safronetz, D.] NIAID, Rocky Mt Lab, Div Intramural Res, NIH, Hamilton, MT 59840 USA. [DiClaro, J. W.] Naval Med Res Unit 3, Cairo, Egypt. [Fair, J.] Fdn Merieux, Washington, DC USA. RP Palacios, G (reprint author), US Army Med Res Inst Infect Dis, 1425 Porter St,Rm 622, Frederick, MD 21702 USA. EM gustavo.f.palacios.ctr@us.army.mil RI Palacios, Gustavo/I-7773-2015; OI Palacios, Gustavo/0000-0001-5062-1938; de Wit, Emmie/0000-0002-9763-7758; Munster, Vincent/0000-0002-2288-3196 FU Defense Threat Reduction Agency FX Funded by the Defense Threat Reduction Agency and others. NR 22 TC 70 Z9 71 U1 2 U2 36 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 EI 1533-4406 J9 NEW ENGL J MED JI N. Engl. J. Med. PD DEC 17 PY 2015 VL 373 IS 25 BP 2448 EP 2454 DI 10.1056/NEJMoa1509773 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA CY5QD UT WOS:000366461400011 PM 26465384 ER PT J AU Kim, HC Timmes, TC Dempsey, BA AF Kim, Hyun-Chul Timmes, Thomas C. Dempsey, Brian A. TI Simultaneous removal of phosphorus and EfOM using MIEX, coagulation, and low-pressure membrane filtration SO ENVIRONMENTAL TECHNOLOGY LA English DT Article DE magnetic ion exchange; in-line coagulation; membrane filtration; phosphorus; EfOM ID MAGNETIC ION-EXCHANGE; SOLUBLE MICROBIAL PRODUCTS; NATURAL ORGANIC-MATTER; WASTE-WATER; ADSORPTIVE CHARACTERISTICS; AQUEOUS-SOLUTIONS; SURFACE-WATER; PILOT-SCALE; HUMIC-ACID; ULTRAFILTRATION AB The feasibility of using magnetic ion exchange (MIEX) treatment, in-line alum coagulation, and low-pressure membrane filtration was investigated for the simultaneous removal of total phosphorus (TP) and effluent organic matter (EfOM) from biologically treated wastewater. The focus was also placed on minimizing fouling of polyvinylidene fluoride and polyethersulfone membranes, which are the most commonly used low-pressure membranes in new and retrofit wastewater treatment plants. MIEX alone was effective for the removal of EfOM, and MIEX plus a small alum dose was very effective in removing both EfOM and TP. MIEX removed phosphorus, but organic acids in EfOM were preferentially removed, and the effects of competing anions on the removal of EfOM were insignificant. All the pretreatment strategies decreased the resistance to filtration. The greatest decrease in fouling was achieved by using MIEX (15mLL(-1)) plus a very low dose of alum (approximate to 0.5mgAlL(-1)). Sweep floc coagulation using alum and without MIEX also significantly decreased fouling but did not effectively remove EfOM and produced high floc volume that could be problematic for inside-out hollow-fibre modules. The addition of these reagents into rapid mix followed by membrane filtration would provide operational simplicity and could be easily retrofitted at existing membrane filtration facilities. [GRAPHICS] . C1 [Kim, Hyun-Chul; Dempsey, Brian A.] Penn State Univ, Dept Civil & Environm Engn, University Pk, PA 16802 USA. [Timmes, Thomas C.] US Army, Ctr Environm Hlth Res, Ft Detrick, MD USA. RP Kim, HC (reprint author), Sejong Univ, Water Resources Res Inst, 98 Gunja Dong, Seoul 143747, South Korea. EM animaplus@hanmail.net FU U.S. Geological Survey under State Water Resources Research Institute Programme [2010PA124B] FX This work was supported by the U.S. Geological Survey under State Water Resources Research Institute Programme [2010PA124B]. NR 41 TC 1 Z9 1 U1 6 U2 19 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND SN 0959-3330 EI 1479-487X J9 ENVIRON TECHNOL JI Environ. Technol. PD DEC 17 PY 2015 VL 36 IS 24 BP 3167 EP 3175 DI 10.1080/09593330.2015.1055819 PG 9 WC Environmental Sciences SC Environmental Sciences & Ecology GA CU7UY UT WOS:000363748500010 PM 26017783 ER PT J AU Niu, L Liu, XF Cong, CX Wu, CY Wu, D Chang, TR Wang, H Zeng, QS Zhou, JD Wang, XL Fu, W Yu, P Fu, QD Najmaei, S Zhang, ZH Yakobson, BI Tay, BK Zhou, W Jeng, HT Lin, H Sum, TC Jin, C He, HY Yu, T Liu, Z AF Niu, Lin Liu, Xinfeng Cong, Chunxiao Wu, Chunyang Wu, Di Chang, Tay Rong Wang, Hong Zeng, Qingsheng Zhou, Jiadong Wang, Xingli Fu, Wei Yu, Peng Fu, Qundong Najmaei, Sina Zhang, Zhuhua Yakobson, Boris I. Tay, Beng Kang Zhou, Wu Jeng, Horng Tay Lin, Hsin Sum, Tze Chien Jin, Chuanhong He, Haiyong Yu, Ting Liu, Zheng TI Controlled Synthesis of Organic/Inorganic van der Waals Solid for Tunable Light-Matter Interactions SO ADVANCED MATERIALS LA English DT Article ID HEXAGONAL BORON-NITRIDE; FIELD-EFFECT TRANSISTORS; GRAPHENE HETEROSTRUCTURES; EPITAXIAL-GROWTH; SOLAR-CELLS; THIN-FILMS; MOS2; HETEROJUNCTIONS; PEROVSKITES; ELECTRONICS C1 [Niu, Lin; Wang, Hong; Zeng, Qingsheng; Zhou, Jiadong; Fu, Wei; Yu, Peng; Fu, Qundong; He, Haiyong; Liu, Zheng] Nanyang Technol Univ, Sch Mat Sci & Engn, Singapore 639798, Singapore. [Liu, Xinfeng; Cong, Chunxiao; Sum, Tze Chien; Yu, Ting] Nanyang Technol Univ, Sch Phys & Math Sci, Singapore 637371, Singapore. [Liu, Xinfeng] Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China. [Wu, Chunyang; Jin, Chuanhong] Zhejiang Univ, State Key Lab Silicon Mat, Hangzhou 310027, Zhejiang, Peoples R China. [Wu, Chunyang; Jin, Chuanhong] Zhejiang Univ, Sch Mat Sci & Engn, Hangzhou 310027, Zhejiang, Peoples R China. [Wu, Di; Lin, Hsin] Natl Univ Singapore, Ctr Adv Mat 2D, Singapore 117542, Singapore. [Wu, Di; Lin, Hsin] Natl Univ Singapore, Dept Phys, Singapore 117542, Singapore. [Chang, Tay Rong; Jeng, Horng Tay] Natl Tsing Hua Univ, Dept Phys, Hsinchu 30013, Taiwan. [Wang, Xingli; Tay, Beng Kang; Liu, Zheng] Nanyang Technol Univ, Nanoelect Ctr Excellence, Sch Elect & Elect Engn, NOVITAS, Singapore 639798, Singapore. [Najmaei, Sina] US Army, Res Labs, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. [Zhang, Zhuhua; Yakobson, Boris I.] Rice Univ, Dept Mat Sci & Nanoengn, Houston, TX 77005 USA. [Zhou, Wu] Oak Ridge Natl Lab, Div Mat Sci & Technol, Oak Ridge, TN 37831 USA. RP He, HY (reprint author), Nanyang Technol Univ, Sch Mat Sci & Engn, Singapore 639798, Singapore. EM HYHe@ntu.edu.sg; YuTing@ntu.edu.sg; Z.Liu@ntu.edu.sg RI Zhou, Wu/D-8526-2011; Lin, Hsin/F-9568-2012; Chang, Tay-Rong/K-3943-2015; Jin, Chuanhong/I-6460-2015; Zhang, Zhuhua/E-8162-2012 OI Zhou, Wu/0000-0002-6803-1095; Lin, Hsin/0000-0002-4688-2315; Chang, Tay-Rong/0000-0003-1222-2527; Jin, Chuanhong/0000-0001-8845-5664; FU Singapore National Research Foundation (NRF) [NRF-RF2013-08]; Nanyang Technological University [M4081137.070, M4080514]; Ministry of Education AcRF Tier 2 [MOE2013-T2-1-081, MOE2014-T2-1-044]; Singapore NRF through Singapore-Berkeley Research Initiative for Sustainable Energy (SinBerRISE) CREATE Programme; Ministry of Education, Singapore [MOE2012-T2-2-049]; National Science Foundation of China [51222202, 51472215]; National Basic Research Program of China [2014CB932500, 2015CB921000]; Fundamental Research Funds for the Central Universities [2014XZZX003-07] FX L.N., X.L., C.C., and C.W. contributed equally to this work. This work was supported by the Singapore National Research Foundation (NRF) under RF Award No. NRF-RF2013-08, the start-up funding from Nanyang Technological University (M4081137.070 and M4080514), and the Ministry of Education AcRF Tier 2 Grants MOE2013-T2-1-081 and MOE2014-T2-1-044. X.L and T.C.S. also acknowledge the financial support by the Singapore NRF through the Singapore-Berkeley Research Initiative for Sustainable Energy (SinBerRISE) CREATE Programme. C.C and T.Y thank the support of Ministry of Education, Singapore (MOE2012-T2-2-049). C.W. and C.J. thank the Center for Electron Microscopy of Zhejiang University for the access to TEM facilities, and the financial support from the National Science Foundation of China (Grant Nos. 51222202 and 51472215), the National Basic Research Program of China (Grant Nos. 2014CB932500 and 2015CB921000), and the Fundamental Research Funds for the Central Universities (Grant No. 2014XZZX003-07). NR 49 TC 10 Z9 10 U1 30 U2 91 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 0935-9648 EI 1521-4095 J9 ADV MATER JI Adv. Mater. PD DEC 16 PY 2015 VL 27 IS 47 BP 7800 EP 7808 DI 10.1002/adma.201503367 PG 9 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA DA5IX UT WOS:000367837900015 PM 26505987 ER PT J AU Pittman, PR Reisler, RB Lindsey, CY Guerena, F Rivard, R Clizbe, DP Chambers, M Norris, S Smith, LA AF Pittman, Phillip R. Reisler, Ronald B. Lindsey, Changhong Y. Gueerena, Fernando Rivard, Robert Clizbe, Denise P. Chambers, Matthew Norris, Sarah Smith, Leonard A. TI Safety and immunogenicity of ricin vaccine, RVEC (TM), in a Phase 1 clinical trial SO VACCINE LA English DT Article DE Ricin vaccine; Recombinant vaccine; Clinical trial; Dose; Safety; Immune response ID PALMITYL TRANSFERASE DEFICIENCY; RIBOSOME-INACTIVATING PROTEINS; VASCULAR LEAK SYNDROME; N-GLYCOSIDASE ACTIVITY; A-CHAIN; SUBUNIT VACCINES; TOXIN; MICE; RNA; RHABDOMYOLYSIS AB Ricin is a potent toxin and potential bioterrorism weapon for which no specific licensed countermeasures are available. We report the safety and immunogenicity of the ricin vaccine RVEc (TM) in a Phase 1 (N = 30) multiple-dose, open-label, non-placebo-controlled, dose-escalating (20, 50, and 100 mu g), single-center study. Each subject in the 20- and 50-mu g dose groups (n = 10 for each group) received three injections at 4-week intervals and was observed carefully for untoward effects of the vaccine; blood was drawn at predetermined intervals after each dose for up to I year. RVEc (TM) was safe and well tolerated at the 20- and 50-mu g doses. The most common adverse events were pain at the injection site and headache. Of the 10 subjects who received a single 100-mu g dose, two developed elevated creatine phosphokinase levels, which resolved without sequelae. No additional doses were administered to subjects in the 100-mu g group. Immunogenicity of the vaccine was evaluated by measuring antibody response using the well standardized enzyme-linked immunosorbent assay (ELISA) and toxin neutralization assay (TNA). Of the subjects in the 20- and 50-mu g dose groups, 100% achieved ELISA anti-ricin IgG titers of 1:500 to 1:121,500 and 50% produced neutralizing anti-ricin antibodies measurable by TNA. Four subjects in the 50-mu g group received a single booster dose of RVEc (TM) 20-21 months after the initial dose. The single booster was safe and well tolerated, resulting in no serious adverse events, and significantly enhanced immunogenicity of the vaccine in human subjects. Each booster recipient developed a robust anamnestic response with ELISA anti-ricin IgG titers of 1:13,500 to 1:121,500 and neutralizing antibody titers of 1:400 to 1:3200. Future studies will attempt to optimize dose, scheduling, and route of administration. This study is registered at clinicaltrials.gov (NCT01317667 and NCT01846104). Published by Elsevier Ltd. C1 [Pittman, Phillip R.; Lindsey, Changhong Y.; Rivard, Robert; Clizbe, Denise P.; Chambers, Matthew; Norris, Sarah; Smith, Leonard A.] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Reisler, Ronald B.] MedStar Georgetown Univ Hosp, Clinton, MD 20735 USA. [Gueerena, Fernando] US Army, Ft Drum, NY 13602 USA. RP Pittman, PR (reprint author), US Army, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. EM phillip.r.pittman.civ@mail.mil FU Defense Threat Reduction Agency, Joint Science and Technology Office for Chemical-Biological Defense FX The authors wish to thank Elizabeth S. Brown, Ph.D., for her editorial contributions to this manuscript. This work was supported by the Defense Threat Reduction Agency, Joint Science and Technology Office for Chemical-Biological Defense. NR 37 TC 4 Z9 5 U1 2 U2 14 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD DEC 16 PY 2015 VL 33 IS 51 BP 7299 EP 7306 DI 10.1016/j.vaccine.2015.10.094 PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA CZ0FD UT WOS:000366779600025 PM 26546259 ER PT J AU Chantawansri, TL Yeh, IC Hsieh, AJ AF Chantawansri, Tanya L. Yeh, In-Chul Hsieh, Alex J. TI Investigating the glass transition temperature at the atom-level in select model polyamides: A molecular dynamics study SO POLYMER LA English DT Article DE Polyamide; Molecular dynamics ID METHYLENE CHAIN UNITS; FREE-VOLUME; MICROPHASE SEPARATION; STRUCTURAL RELAXATION; MECHANICAL-PROPERTIES; COMPUTER-SIMULATIONS; THERMAL-ANALYSIS; FORCE-FIELD; CRYSTALLINITY; POLYMERS AB The molecular influence on glass transition temperature (T-g) of select model polyamides was investigated by atomistic modeling. These include nylon 6,6, nylon 6,12, a cycloaliphatic polyamide consisting of 4,4'-methylene-bis(cyclohexylamine) and dodecanedioic acid, as well as a corresponding aromatic counterpart consisting of 4,4'-methylenedianiline and dodecanedioic acid. For each model system, all-atom atomistic molecular dynamics simulations were used to discern and differentiate parameters such as free volume, hydrogen bonding, and chain rigidity. Simulations were able to predict the correct trend in T-g, where the model cycloaliphatic polyamide was shown to have the highest Tg followed by the aromatic polyamide. This is presumably due to the greater chain rigidity exhibited by the cycloaliphatic polyamide around the cyclohexyl ring, which was revealed through a calculation of the dihedral rotation free energy barrier associated with the methylene moiety between either the bis-cyclohexyl or bis-phenyl rings, despite the former having a higher extent of free volume. Published by Elsevier Ltd. C1 [Chantawansri, Tanya L.; Yeh, In-Chul; Hsieh, Alex J.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Chantawansri, TL (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM tanya.chantawansri.civ@mail.mil FU U.S. Army Research Laboratory (ARL) FX This work was supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Research Laboratory (ARL) administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and ARL. The authors would like to thank Dr. F.T. Willmore for useful discussion and for use of his CESA program and scripts. Calculations were performed using the DOD Supercomputing Resource Center located at the Air Force Laboratory. NR 61 TC 2 Z9 2 U1 7 U2 30 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0032-3861 EI 1873-2291 J9 POLYMER JI Polymer PD DEC 16 PY 2015 VL 81 BP 50 EP 61 DI 10.1016/j.polymer.2015.09.069 PG 12 WC Polymer Science SC Polymer Science GA CX6LZ UT WOS:000365813800007 ER PT J AU Bruhl, JC Varma, AH Kim, JM AF Bruhl, Jakob C. Varma, Amit H. Kim, Joo Min TI Static resistance function for steel-plate composite (SC) walls subject to impactive loading SO NUCLEAR ENGINEERING AND DESIGN LA English DT Article ID SHEAR CONNECTORS; CONCRETE; DESIGN; PERFORATION; BEHAVIOR; DATABASE; SAFETY AB Steel-plate composite (SC) walls consist of a plain concrete core reinforced with two steel faceplates on the surfaces. Modules (consisting of steel faceplates, shear connectors and tie-bars) can be shop-fabricated and shipped to the site for erection and concrete casting, which expedites construction schedule and thus economy. SC structures have recently been used in nuclear power plant designs and are being considered for the next generation of small modular reactors. Design for impactive and impulsive loading is an important consideration for SC walls in safety-related nuclear facilities. The authors have previously developed design methods to prevent local failure (perforation) of SC walls due to missile impact. This paper presents the development of static resistance functions for use in single-degree-of-freedom (SDOF) analyses to predict the maximum displacement response of SC walls subjected to missile impact and designed to resist local failure (perforation). The static resistance function for SC walls is developed using results of numerical analyses and parametric studies conducted using benchmarked 3D finite element (FE) models. The influence of various design parameters are discussed and used to develop idealized bilinear resistance functions for SC walls with fixed edges and simply supported edges. Results from dynamic non-linear FE analysis of SC panels subjected to rigid missile impact are compared with the maximum displacements predicted by SDOF analyses using the bilinear resistance function. Published by Elsevier B.V. C1 [Bruhl, Jakob C.; Varma, Amit H.; Kim, Joo Min] Purdue Univ, Lyles Sch Civil Engn, W Lafayette, IN 47907 USA. RP Bruhl, JC (reprint author), US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. EM jbruhl@purdue.edu; ahvarma@purdue.edu; kim1493@purdue.edu OI Bruhl, Jakob/0000-0002-1645-4520 NR 35 TC 1 Z9 1 U1 1 U2 4 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0029-5493 EI 1872-759X J9 NUCL ENG DES JI Nucl. Eng. Des. PD DEC 15 PY 2015 VL 295 BP 843 EP 859 DI 10.1016/j.nucengdes.2015.07.037 PG 17 WC Nuclear Science & Technology SC Nuclear Science & Technology GA CZ9JK UT WOS:000367413700079 ER PT J AU Mullins, JC Van Ert, M Hadfield, T Nikolich, MP Hugh-Jones, ME Blackburn, JK AF Mullins, Jocelyn C. Van Ert, Matthew Hadfield, Ted Nikolich, Mikeljon P. Hugh-Jones, Martin E. Blackburn, Jason K. TI Spatio-temporal patterns of an anthrax outbreak in white-tailed deer, Odocoileus virginanus, and associated genetic diversity of Bacillus anthracis SO BMC ECOLOGY LA English DT Article DE Bacillus anthracis; Anthrax; Wildlife; Genetic diversity; Outbreak; Transmission ID WEST TEXAS; SPATIAL-PATTERNS; REPEAT ANALYSIS; NATIONAL-PARK; WILDLIFE; USA; EPIZOOTICS; LIVESTOCK; SOFTWARE; DISEASE AB Background: Anthrax, a soil-borne zoonosis caused by the bacterium Bacillus anthracis, is enzootic in areas of North America with frequent outbreaks in west Texas. Despite a long history of study, pathogen transmission during natural outbreaks remains poorly understood. Here we combined case-level spatio-temporal analysis and high resolution genotyping to investigate anthrax transmission dynamics. Carcass locations from a single white-tailed deer, Odocoileus virginanus, outbreak were analyzed for spatial clustering using K-function analysis and directionality with trend surface analysis and the direction test. Results: The directionalities were compared to results of high resolution genotyping. The results of the spatial clustering analyses, combined with deer movement data, suggest anthrax transmission events occur within limited spatial areas, with carcass locations occurring within the activity space of adjacent cases. The directionality of the outbreak paralleled adjacent dry river beds. Isolates from the outbreak were represented by a single genotype based on multiple locus variable number tandem repeat analysis (MLVA); four sub-genotypes were identified using single nucleotide repeat (SNR) analysis. Conclusions: Areas of high transmission agreed spatially with areas of higher SNR genetic diversity; however, SNRs did not provide clear evidence of linear transmission. Overlap of case home ranges provides spatial and temporal support for localized transmission, which may include the role of necrophagous or hematophagous flies in outbreaks in this region. These results emphasize the need for active surveillance and prompt cleanup of anthrax carcasses to control anthrax both during outbreaks and between seasons. C1 [Mullins, Jocelyn C.; Van Ert, Matthew; Blackburn, Jason K.] Univ Florida, Dept Geog, Spatial Epidemiol & Ecol Res Lab, Gainesville, FL 32611 USA. [Mullins, Jocelyn C.; Van Ert, Matthew; Hadfield, Ted; Blackburn, Jason K.] Univ Florida, Emerging Pathogens Inst, Gainesville, FL 32611 USA. [Nikolich, Mikeljon P.] Walter Reed Army Inst Res, Dept Emerging Bacterial Infect Bacterial Dis Bran, Silver Spring, MD USA. [Hugh-Jones, Martin E.] Louisiana State Univ, Sch Coast & Environm, Dept Environm Sci, Baton Rouge, LA 70803 USA. RP Blackburn, JK (reprint author), Univ Florida, Emerging Pathogens Inst, Gainesville, FL 32611 USA. EM jkblackburn@ufl.edu FU Spatial Epidemiology and Ecology Research Lab; Emerging Pathogens Institute at UF; [NSF-1203557] FX SNR work was sponsored by NSF-1203557 to JKB and JCM. Additional support was provided by the Spatial Epidemiology and Ecology Research Lab and the Emerging Pathogens Institute at UF. DNA from the outbreak were provided to UF by Walter Reed Army Medical Institute of Research. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The findings and opinions expressed herein belong to the authors and do not necessarily reflect the official views of the Walter Reed Army Institute of Research, the U.S. Army or the Department of Defense. NR 47 TC 0 Z9 0 U1 4 U2 13 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1472-6785 J9 BMC ECOL JI BMC Ecol. PD DEC 15 PY 2015 VL 15 AR 23 DI 10.1186/s12898-015-0054-8 PG 11 WC Ecology SC Environmental Sciences & Ecology GA CZ6RZ UT WOS:000367229700001 PM 26669305 ER PT J AU Bright, CJ Nallon, EC Polcha, MP Schnee, VP AF Bright, Collin J. Nallon, Eric C. Polcha, Michael P. Schnee, Vincent P. TI Quantum Dot and Polymer Composite Cross-Reactive Array for Chemical Vapor Detection SO ANALYTICAL CHEMISTRY LA English DT Article ID SENSOR ARRAY; NOSE TECHNOLOGY; ELECTRONIC NOSE; EXPLOSIVES; DISCRIMINATION; PHOTODETECTORS; BREATH; FILMS; LUNG AB A cross-reactive chemical sensing array was made from CdSe Quantum Dots (QDs) and five different organic polymers by inkjet printing to create segmented fluorescent composite regions on quartz substrates. The sensor array was challenged with exposures from two sets of analytes, including one set of 14 different functionalized benzenes and one set of 14 compounds related to security concerns, including the explosives trinitrotoluene (TNT) and ammonium nitrate. The array was broadly responsive to analytes with different chemical functionalities due to the multiple sensing mechanisms that altered the QDs' fluorescence. The sensor array displayed excellent discrimination between members within both sets. Classification accuracy of more than 93% was achieved, including the complete discrimination of very similar dinitrobenzene isomers and three halogenated, substituted benzene compounds. The simple fabrication, broad responsivity, and high discrimination capacity of this type of cross-reactive array are ideal qualities for the development of sensors with excellent sensitivity to chemical and explosive threats while maintaining low false alarm rates. C1 [Bright, Collin J.; Nallon, Eric C.; Polcha, Michael P.; Schnee, Vincent P.] US Army, RDECOM CERDEC Night Vis & Elect Sensors Directora, Ft Belvoir, VA 22060 USA. [Bright, Collin J.] CACI Int Inc Arlington, Arlington, VA 22201 USA. [Polcha, Michael P.] Fulcrum IT Serv, Centerville, VA 20120 USA. RP Schnee, VP (reprint author), US Army, RDECOM CERDEC Night Vis & Elect Sensors Directora, Ft Belvoir, VA 22060 USA. EM vincent.p.schnee.civ@mail.mil NR 41 TC 1 Z9 1 U1 19 U2 68 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0003-2700 EI 1520-6882 J9 ANAL CHEM JI Anal. Chem. PD DEC 15 PY 2015 VL 87 IS 24 BP 12270 EP 12275 DI 10.1021/acs.analchem.5b03559 PG 6 WC Chemistry, Analytical SC Chemistry GA CZ1NC UT WOS:000366871500045 PM 26548712 ER PT J AU Kaplan, JE Bateganya, MH Hamm, TE Langley, C AF Kaplan, Jonathan E. Bateganya, Moses H. Hamm, Tiffany E. Langley, Carol TI Authors' Reply: Evidence-Based Programming of HIV Care and Support: Is the Psychosocial "Optional"? SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Letter ID CLINICAL-OUTCOMES; INTERVENTIONS; IMPACT; COUNTRIES C1 [Kaplan, Jonathan E.; Bateganya, Moses H.] Ctr Dis Control & Prevent, Div Global HIV AIDS, Atlanta, GA USA. [Hamm, Tiffany E.] Walter Reed Army Inst Res, Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Langley, Carol] US Dept State, Off US Global AIDS Coordinator & Hlth Diplomacy, Washington, DC 20520 USA. RP Kaplan, JE (reprint author), Ctr Dis Control & Prevent, Div Global HIV AIDS, Atlanta, GA USA. NR 11 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1525-4135 EI 1077-9450 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD DEC 15 PY 2015 VL 70 IS 5 BP E178 EP E179 DI 10.1097/QAI.0000000000000840 PG 2 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA CX3LN UT WOS:000365600400006 PM 26569180 ER PT J AU Sarney, WL Svensson, SP AF Sarney, Wendy L. Svensson, Stefan P. TI Composition modulated InAsSb superlattice induced by non-incorporating Bismuth SO JOURNAL OF CRYSTAL GROWTH LA English DT Article DE Crystal structure; X-ray diffraction; Molecular beam epitaxy; Semiconducting III-V materials ID GROWTH AB We report a new method for synthesizing a composition superlattice with molecular beam epitaxy. A repeated structure of InAs(l-x)Sb(x)/InAs(1-y)Sb(y) was induced by periodic cycling of a non-incorporating Bi-flux, while keeping the In-, As- and Sb-fluxes constant. The Bi acts as a virtual chemical valve. Highresolution X-ray diffraction demonstrated a modulation ratio of x/y=1:1.3. Composition broadening could not be detected within the experimental resolution. The Bi, despite not incorporating, also does not remain on the growing surface after the incoming Bi-flux is terminated. Published by Elsevier B.V. C1 [Sarney, Wendy L.; Svensson, Stefan P.] US Army Res Lab, Adelphi, MD 20783 USA. RP Sarney, WL (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 12 TC 0 Z9 0 U1 3 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-0248 EI 1873-5002 J9 J CRYST GROWTH JI J. Cryst. Growth PD DEC 15 PY 2015 VL 432 BP 105 EP 107 DI 10.1016/j.jcrysgro.2015.08.026 PG 3 WC Crystallography; Materials Science, Multidisciplinary; Physics, Applied SC Crystallography; Materials Science; Physics GA CW2JX UT WOS:000364819400017 ER PT J AU Kinzel, EC Ginn, JC Florence, LA Lail, BA Boreman, GD AF Kinzel, Edward C. Ginn, James C. Florence, Louis A. Lail, Brian A. Boreman, Glenn D. TI Directional thermal emission from a leaky-wave frequency-selective surface SO JOURNAL OF NANOPHOTONICS LA English DT Article DE frequency-selective surface; metasurface; thermal emission; infrared antenna; hemispherical directional reflectometer ID ANTENNA; LIGHT; DESIGN; BAND AB We design, fabricate, and characterize a frequency-selective surface (FSS) with directional thermal emission and absorption for long-wave infrared wavelengths. The FSS consists of an array of patch antennas connected by microstrips, the ensemble of which supports leakywave-type modes with forward and backward propagating branches. The branches are designed to intersect at 9.8 mu m and have a broadside beam with 20-deg full width at half maximum at this wavelength. The absorption along these branches is near unity. Measurement of the hemispherical directional reflectometer shows good agreement with simulation. The ability to control the spectral and directional emittance/absorptance profiles of surfaces has significant applications for radiation heat transfer and sensing. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. C1 [Kinzel, Edward C.] Missouri Univ Sci & Technol, Dept Mech & Aerosp Engn, 400 West 13th St, Rolla, MO 65409 USA. [Ginn, James C.] Plasmonics Inc, Orlando, FL 32826 USA. [Florence, Louis A.] US Mil Acad, Phys & Nucl Engn Dept, Ctr Sci, West Point, NY 10996 USA. [Lail, Brian A.] Florida Inst Technol, Elect & Comp Engn, Melbourne, FL 32901 USA. [Boreman, Glenn D.] Univ N Carolina, Phys & Opt Sci, Charlotte, NC 28223 USA. RP Kinzel, EC (reprint author), Missouri Univ Sci & Technol, Dept Mech & Aerosp Engn, 400 West 13th St, Rolla, MO 65409 USA. EM kinzele@mst.edu RI Lail, Brian/L-6382-2015 OI Lail, Brian/0000-0001-6039-3385 NR 20 TC 0 Z9 0 U1 11 U2 18 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 1934-2608 J9 J NANOPHOTONICS JI J. Nanophotonics PD DEC 14 PY 2015 VL 9 AR 093040 DI 10.1117/1.JNP.9.093040 PG 7 WC Nanoscience & Nanotechnology; Optics SC Science & Technology - Other Topics; Optics GA DJ5HW UT WOS:000374238500001 ER PT J AU Wang, CJ Gong, ZY Pan, YL Videen, G AF Wang, Chuji Gong, Zhiyong Pan, Yong-Le Videen, Gorden TI Optical trap-cavity ringdown spectroscopy as a single-aerosol-particle-scope SO APPLIED PHYSICS LETTERS LA English DT Article ID ABSORBING PARTICLES; ATMOSPHERIC AEROSOL; REFRACTIVE-INDEX; RAMAN-SPECTRA; LASER-BEAM; EXTINCTION; AIR; RETRIEVAL; DROPLETS; SIZE AB We report a single-aerosol-particle-scope using an optical trapping-cavity ringdown spectroscopy technique. The scope can not only view physical parameters such as size, motion, and restoring force constant of a single aerosol particle trapped in air but also display time-, particle-, or wavelength-resolved chemical properties such as single aerosol particle extinction. We demonstrate the scope by trapping and walking single carbon-nanotube particles of similar to 50 mu m in size and viewing those properties via changes of ringdown time. This single-aerosol-particle-scope offers a powerful tool to study both physical and chemical properties as well as their evolving dynamics. (C) 2015 AIP Publishing LLC. C1 [Wang, Chuji; Gong, Zhiyong] Mississippi State Univ, Dept Phys & Astron, Starkville, MI 39759 USA. [Pan, Yong-Le; Videen, Gorden] US Army, Res Lab, Adelphi, MD 20783 USA. RP Wang, CJ (reprint author), Mississippi State Univ, Dept Phys & Astron, Starkville, MI 39759 USA. EM cw175@msstate.edu OI Gong, Zhiyong/0000-0002-3004-1589 FU U.S. Army Research Office [W911NF-13-1-0429, W911NF-12-2-0019] FX This research was supported by the U.S. Army Research Office Grant Nos. W911NF-13-1-0429 and W911NF-12-2-0019. NR 34 TC 2 Z9 2 U1 6 U2 19 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD DEC 14 PY 2015 VL 107 IS 24 AR 241903 DI 10.1063/1.4937467 PG 5 WC Physics, Applied SC Physics GA CZ7ZF UT WOS:000367318600019 ER PT J AU Coller, BA Barrett, ADT Thomas, SJ AF Coller, Beth-Ann Barrett, Alan D. T. Thomas, Stephen J. TI SPECIAL ISSUE: Dengue Vaccines Introduction SO VACCINE LA English DT Editorial Material C1 [Coller, Beth-Ann] Merck & Co Inc, Kenilworth, NJ 07033 USA. [Barrett, Alan D. T.] Univ Texas Med Branch, Sealy Ctr Vaccine Dev, Galveston, TX 77555 USA. [Thomas, Stephen J.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Coller, BA (reprint author), Merck & Co Inc, 2000 Galloping Hill Rd, Kenilworth, NJ 07033 USA. EM Beth-ann.coller@merck.com; abarrett@utmb.edu; Stephen.j.thomas3.mil@mail.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD DEC 10 PY 2015 VL 33 IS 50 SI SI BP 7049 EP 7050 PG 2 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA CZ0CA UT WOS:000366771500001 PM 26597033 ER PT J AU Rothman, AL Currier, JR Friberg, HL Mathew, A AF Rothman, Alan L. Currier, Jeffrey R. Friberg, Heather L. Mathew, Anuja TI Analysis of cell-mediated immune responses in support of dengue vaccine development efforts SO VACCINE LA English DT Article DE Dengue; Cell-mediated immunity; Vaccine ID CD8(+) T-CELL; QUALITY-ASSURANCE PROGRAM; VIRUS-INFECTION; HEMORRHAGIC-FEVER; SECONDARY INFECTION; ANTIBODY-RESPONSE; CROSS-REACTIVITY; PROTECTIVE ROLE; FLOW-CYTOMETRY; CLINICAL-TRIAL AB Dengue vaccine development has made significant strides, but a better understanding of how vaccine-induced immune responses correlate with vaccine efficacy can greatly accelerate development, testing, and deployment as well as ameliorate potential risks and safety concerns. Advances in basic immunology knowledge and techniques have already improved our understanding of cell-mediated immunity of natural dengue virus infection and vaccination. We conclude that the evidence base is adequate to argue for inclusion of assessments of cell-mediated immunity as part of clinical trials of dengue vaccines, although further research to identify useful correlates of protective immunity is needed. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Rothman, Alan L.; Mathew, Anuja] Univ Rhode Isl, Inst Immunol & Informat, Providence, RI 02903 USA. [Rothman, Alan L.; Mathew, Anuja] Univ Rhode Isl, Dept Cell & Mol Biol, Providence, RI 02903 USA. [Currier, Jeffrey R.; Friberg, Heather L.] Walter Reed Army Inst Res, Virus Dis Branch, Silver Spring, MD USA. RP Rothman, AL (reprint author), Univ Rhode Isl, Inst Immunol & Informat, 80 Washington St, Providence, RI 02903 USA. EM alan_rothman@uri.edu; jeffrey.r.currier.ctr@mail.mil; heather.l.friberg-robertson.ctr@mail.mil; mathewa@uri.edu OI Rothman, Alan/0000-0002-4064-6848 NR 94 TC 0 Z9 0 U1 3 U2 6 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD DEC 10 PY 2015 VL 33 IS 50 SI SI BP 7083 EP 7090 DI 10.1016/j.vaccine.2015.09.104 PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA CZ0CA UT WOS:000366771500006 PM 26458801 ER PT J AU Cresce, AV Gobet, M Borodin, O Peng, J Russell, SM Wikner, E Fu, A Hu, LB Lee, HS Zhang, ZC Yang, XQ Greenbaum, S Amine, K Xu, K AF Cresce, Arthur von Wald Gobet, Mallory Borodin, Oleg Peng, Jing Russell, Selena M. Wikner, Emily Fu, Adele Hu, Libo Lee, Hung-Sui Zhang, Zhengcheng Yang, Xiao-Qing Greenbaum, Steven Amine, Khalil Xu, Kang TI Anion Solvation in Carbonate-Based Electrolytes SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID HIGHLY ASSOCIATED SALTS; LITHIUM-ION BATTERIES; PROPYLENE CARBONATE; MOLECULAR-DYNAMICS; TRIS(PENTAFLUOROPHENYL) BORANE; STRUCTURAL INTERACTIONS; ORGANIC ELECTROLYTES; GRAPHITIC ANODE; SOLVENT; INTERPHASE AB With the correlation between Li+ solvation and interphasial chemistry on anodes firmly established in Li-ion batteries, the effect of cation-solvent interaction has gone beyond bulk thermodynamic and transport properties and become an essential element that determines the reversibility of electrochemistry and kinetics of Li-ion intercalation chemistries. As of now, most studies are dedicated to the solvation of Li+, and the solvation of anions in carbonate-based electrolytes and its possible effect on the electrochemical stability of such electrolytes remains little understood. As a mirror effort to prior Li+ solvation studies, this work focuses on the interactions between carbonate-based solvents and two anions (hexafluorophosphate, PF6-, and tetrafluoroborate, BF4-) that are most frequently used in Li-ion batteries. The possible correlation between such interaction and the interphasial chemistry on cathode surface is also explored. C1 [Cresce, Arthur von Wald; Borodin, Oleg; Russell, Selena M.; Wikner, Emily; Fu, Adele; Xu, Kang] US Army, Res Lab, Electrochem Branch, Sensors & Electron Devices, Adelphi, MD 20783 USA. [Gobet, Mallory; Peng, Jing; Greenbaum, Steven] CUNY, Dept Phys & Astron, New York, NY 10065 USA. [Peng, Jing] CUNY, Chem Doctorate Program, New York, NY 10065 USA. [Hu, Libo; Zhang, Zhengcheng; Amine, Khalil] Argonne Natl Lab, Chem Sci & Engn Div, Argonne, IL 60439 USA. [Lee, Hung-Sui; Yang, Xiao-Qing] Brookhaven Natl Lab, Dept Chem, Long Isl City, NY 11973 USA. RP Cresce, AV (reprint author), US Army, Res Lab, Electrochem Branch, Sensors & Electron Devices, Adelphi, MD 20783 USA. EM arthur.v.cresce.civ@mail.mil RI Borodin, Oleg/B-6855-2012; Gobet, Mallory/I-2498-2013 OI Borodin, Oleg/0000-0002-9428-5291; Gobet, Mallory/0000-0001-9735-0741 FU US Department of Energy [DE-EE0006543]; American Society for Engineer Education under summer internship at ARL FX This work is partially funded by US Department of Energy under the Interagency Agreement No. DE-EE0006543. Dr. Selena Russell was supported by an appointment to the US Army Research Laboratory (ARL) Fellowship Program administered by the Oak Ridge Associated Universities through a cooperative agreement with ARL. The authors also thank Yue Li from Department of Chemistry at University of Maryland College Park for his assistance with the mass spectrometry experiments. Ms. Emily Wilmer and Ms. Adele Fu were supported by American Society for Engineer Education under summer internship at ARL. NR 49 TC 6 Z9 6 U1 9 U2 55 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD DEC 10 PY 2015 VL 119 IS 49 BP 27255 EP 27264 DI 10.1021/acs.jpcc.5b08895 PG 10 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA CY3VW UT WOS:000366339000009 ER PT J AU Ladner, JT Wiley, MR Mate, S Dudas, G Prieto, K Lovett, S Nagle, ER Beitzel, B Gilbert, ML Fakoli, L Diclaro, JW Schoepp, RJ Fair, J Kuhn, JH Hensley, LE Park, DJ Sabeti, PC Rambaut, A Sanchez-Lockhart, M Bolay, FK Kugelman, JR Palacios, G AF Ladner, Jason T. Wiley, Michael R. Mate, Suzanne Dudas, Gytis Prieto, Karla Lovett, Sean Nagle, Elyse R. Beitzel, Brett Gilbert, Merle L. Fakoli, Lawrence Diclaro, Joseph W., II Schoepp, Randal J. Fair, Joseph Kuhn, Jens H. Hensley, Lisa E. Park, Daniel J. Sabeti, Pardis C. Rambaut, Andrew Sanchez-Lockhart, Mariano Bolay, Fatorma K. Kugelman, Jeffrey R. Palacios, Gustavo TI Evolution and Spread of Ebola Virus in Liberia, 2014-2015 SO CELL HOST & MICROBE LA English DT Article ID RAPID RESPONSE; 2014 OUTBREAK; SIERRA-LEONE; REMOTE AREAS; WEST-AFRICA; TRANSMISSION; EPIDEMIC; GUINEA AB The 2013-present Western African Ebola virus disease (EVD) outbreak is the largest ever recorded with >28,000 reported cases. Ebola virus (EBOV) genome sequencing has played an important role throughout this outbreak; however, relatively few sequences have been determined from patients in Liberia, the second worst-affected country. Here, we report 140 EBOV genome sequences from the second wave of the Liberian outbreak and analyze them in combination with 782 previously published sequences from throughout the Western African outbreak. While multiple early introductions of EBOV to Liberia are evident, the majority of Liberian EVD cases are consistent with a single introduction, followed by spread and diversification within the country. Movement of the virus within Liberia was widespread, and reintroductions from Liberia served as an important source for the continuation of the already ongoing EVD outbreak in Guinea. Overall, little evidence was found for incremental adaptation of EBOV to the human host. C1 [Ladner, Jason T.; Wiley, Michael R.; Mate, Suzanne; Prieto, Karla; Lovett, Sean; Nagle, Elyse R.; Beitzel, Brett; Sanchez-Lockhart, Mariano; Kugelman, Jeffrey R.; Palacios, Gustavo] US Army, Ctr Genome Sci, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Dudas, Gytis; Rambaut, Andrew] Univ Edinburgh, Inst Evolutionary Biol, Ashworth Labs, Edinburgh EH9 3FL, Midlothian, Scotland. [Gilbert, Merle L.] US Army, Mol & Translat Sci Div, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Fakoli, Lawrence; Bolay, Fatorma K.] Liberian Inst Biomed Res, Charlesville, Liberia. [Diclaro, Joseph W., II] Naval Med Res Unit 3, Cairo 11517, Egypt. [Schoepp, Randal J.] US Army, Diagnost Syst Div, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Fair, Joseph] MRI Global, Rockville, MD 20850 USA. [Fair, Joseph] Penn State Univ, Huck Inst Life Sci, University Pk, PA 16802 USA. [Kuhn, Jens H.; Hensley, Lisa E.] NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD 21702 USA. [Park, Daniel J.; Sabeti, Pardis C.] Broad Inst, Cambridge, MA 02142 USA. [Sabeti, Pardis C.] Harvard Univ, Cambridge, MA 02138 USA. [Rambaut, Andrew] Univ Edinburgh, Ashworth Labs, Ctr Immunol Infect & Evolut, Edinburgh EH9 3FL, Midlothian, Scotland. [Rambaut, Andrew] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. RP Ladner, JT (reprint author), US Army, Ctr Genome Sci, Med Res Inst Infect Dis, 1425 Porter St, Frederick, MD 21702 USA. EM jason.t.ladner.ctr@mail.mil; gustavo.f.palacios.ctr@mail.mil RI Palacios, Gustavo/I-7773-2015; OI Palacios, Gustavo/0000-0001-5062-1938; Dudas, Gytis/0000-0002-0227-4158 FU Defense Threat Reduction Agency; S Agency for International Development; EU [278433-PREDEMICS]; National Institute of Allergy and Infectious Diseases [HHSN272200700016I]; Global Biosurveillance Technology Initiative; Global Emerging Infections System FX This work was supported by the Defense Threat Reduction Agency, Global Biosurveillance Technology Initiative, Global Emerging Infections System and US Agency for International Development. A.R. was supported by EU Seventh Framework Programme (FP7/2007-2013) under Grant Agreement no. 278433-PREDEMICS. The content of this publication does not necessarily reflect the views or policies of the US Army, the US Dept of Defense, the US Dept of Health and Human Services or the institutions/companies affiliated with the authors. J.H.K. performed this work as an employee of Tunnell Government Services, Inc., a subcontractor to Battelle Memorial Institute under its prime contract with the National Institute of Allergy and Infectious Diseases (Contract No. HHSN272200700016I). NR 44 TC 18 Z9 18 U1 4 U2 41 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 1931-3128 EI 1934-6069 J9 CELL HOST MICROBE JI Cell Host Microbe PD DEC 9 PY 2015 VL 18 IS 6 BP 659 EP 669 DI 10.1016/j.chom.2015.11.008 PG 11 WC Microbiology; Parasitology; Virology SC Microbiology; Parasitology; Virology GA CY1AL UT WOS:000366138400008 PM 26651942 ER PT J AU Liu, F Kozlovskaya, V Medipelli, S Xue, B Ahmad, F Saeed, M Cropek, D Kharlampieva, E AF Liu, Fei Kozlovskaya, Veronika Medipelli, Srikanth Xue, Bing Ahmad, Fahim Saeed, Mohammad Cropek, Donald Kharlampieva, Eugenia TI Temperature-Sensitive Polymersomes for Controlled Delivery of Anticancer Drugs SO CHEMISTRY OF MATERIALS LA English DT Article ID TRIBLOCK COPOLYMER VESICLES; BLOCK-COPOLYMERS; RAFT POLYMERIZATION; NANOPARTICLES; MICELLES; POLY(N-VINYLCAPROLACTAM); RELEASE; SYSTEM; PH; POLY(N-ISOPROPYLACRYLAMIDE) AB We report on a novel type of triblock copolymer polymersomes with temperature-controlled permeability within the physiologically relevant temperature range of 37-42 degrees C for sustained delivery of anticancer drugs. These polymersomes combine characteristics of liposomes, such as biocompatibility, biodegradability, monodispersity, and stability at room temperature, with tunable size and thermal responsiveness provided by amphiphilic triblock copolymers. The temperature-sensitive poly(N-vinylcaprolactam)(n)-poly(dimethylsiloxane)(65)-poly(N-vinylcaprolactam)(n) (PVCLn-PDMS65-PVCLn) copolymers with n = 10, 15, 19, 29, and 50 and polydispersity indexes less than 1.17 are synthesized by controlled RAFT polymerization. The copolymers are assembled into stable vesicles at room temperature when the ratio of PVCL to the total polymer mass is 0.36 = 950 degrees C). Samples sealed in evacuated tubes did not explode, while if sealed under N-2 the explosive effect was intensified. Thus, explosive behavior was attributed to rapid heating and expansion of gas filling nanoporous space. However, although that condition was necessary for explosive behavior, it was not sufficient. Based on SEM, particle sizes via N-2, sorption, electrical conductivity measurements and mechanical strength data under quasi-static compression, it was concluded that the boundaries between the three types of behavior after ignition were associated with (a) mild sintering (fizzling/explosive boundary at around 500 degrees C); and, (b) melting-like fusion of skeletal nanoparticles (explosive/thermite boundary at around 950 degrees C). Overall, mechanically weaker networks fizzled out; too strong behaved as thermites; networks of intermediate strength exploded. For thermite behavior in particular, other factors may be also at play, such as a combination of reduced porosity, a substoichiometric ambunt of LiClO4 and a slower heat release rate. The latter was supported by TGA data in O-2 and was attributed to a slower rate of oxidation of progressively thicker nanostructures as the H-2-reduction temperature increased. C1 [Leventis, Nicholas; Donthula, Suraj; Mandal, Chandana; Sotiriou-Leventis, Chariklia] Missouri Univ Sci & Technol, Dept Chem, Rolla, MO 65409 USA. [Ding, Michael S.] Army Res Lab, Electrochem Branch, Adelphi, MD 20783 USA. RP Leventis, N (reprint author), Missouri Univ Sci & Technol, Dept Chem, Rolla, MO 65409 USA. EM leventis@mst.edu; michael.s.ding.civ@mail.mil; cslevent@mst.edu FU Army Research Office [W911NF-12-2-0029] FX We thank the Army Research Office for financial support under Cooperative Agreement No. W911NF-12-2-0029. We also thank the Materials Research Center of MS&T for support with materials characterization. NR 35 TC 2 Z9 2 U1 2 U2 16 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0897-4756 EI 1520-5002 J9 CHEM MATER JI Chem. Mat. PD DEC 8 PY 2015 VL 27 IS 23 BP 8126 EP 8137 DI 10.1021/acs.chemmater.5b03898 PG 12 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA CY2FC UT WOS:000366223200033 ER PT J AU Christensen, G Younes, H Hong, HP Smith, P AF Christensen, Greg Younes, Hammad Hong, Haiping Smith, Pauline TI Effects of solvent hydrogen bonding, viscosity, and polarity on the dispersion and alignment of nanofluids containing Fe2O3 nanoparticles SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID THERMAL-CONDUCTIVITY ENHANCEMENT; HEAT-TRANSFER; TRANSPORT-PROPERTIES; WATER NANOFLUIDS; ETHYLENE GLYCOL; OXIDE SURFACES; ZNO; SUSPENSIONS; AL2O3; TEMPERATURE AB It has been shown that the alignment of Iron (III) oxide (Fe2O3) nanoparticles in water (H2O) can enhance the thermal conductivity of nanofluids. To better understand solvent effects such as hydrogen bonding, viscosity, and polarity, nanofluids were prepared by mixing Fe2O3 nanoparticles and various solvents (water, ethanol, 1-propanol, isopropanol, 2-propanone, hexane, cyclohexane, ethylene glycol, glycerol, etc.), and the dispersions and alignments of the Fe2O3 nanoparticles in these solvents with and without an applied magnetic field were investigated using an optical microscope. The microscope images indicated that inter-molecule hydrogen bonding of the solvents with one OH group (water, ethanol, 1-propanol, and isopropanol) could help to disperse and align the Fe2O3 nanoparticles. The intra-molecular hydrogen bonding causes a dramatic increase in viscosity for fluids with multiple OH groups, such as ethylene glycol (C2H6O2) and glycerol (C3H8O3), and makes the Fe2O3 nanoparticles dispersion and alignment difficult. Adding water to those fluids could lead to significantly reduced viscosity and make the particles disperse and align well. Polarity studies indicated that higher polarity yields better dispersion and alignment of the Fe2O3 nanoparticles. Thermal studies showed that thermal conductivity of nanofluids containing metal oxide particles with hydrogen bonding in solvents is enhanced compared to the theoretically calculated data. Intermolecular hydrogen bonding between water and ethylene glycol increases the thermal conductivity of nanofluids while decreasing the fluid viscosity. The results also well explain why 50 wt. % water/50 wt. % ethylene glycol is an excellent commercial coolant. Since high thermal conductivity enhancement with minimal viscosity increase is the primary goal of heat transfer nanofluids, this current research may open new doors to better understanding of the fundamental nature of nanofluids. (C) 2015 AIP Publishing LLC. C1 [Christensen, Greg; Younes, Hammad; Hong, Haiping] South Dakota Sch Mines & Technol, Dept Mat & Met Engn, Rapid City, SD 57701 USA. [Smith, Pauline] US Army Res Lab, Aberdeen, MD 21005 USA. RP Hong, HP (reprint author), South Dakota Sch Mines & Technol, Dept Mat & Met Engn, Rapid City, SD 57701 USA. EM haiping.hong@sdsmt.edu FU Army Research Laboratory [W911NF-08-2-0022]; NASA EPSCoR [NNX09AU83A] FX The financial support of Army Research Laboratory_Cooperative Agreement No. W911NF-08-2-0022 and NASA EPSCoR_Award No. NNX09AU83A is acknowledged. NR 45 TC 1 Z9 1 U1 6 U2 10 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD DEC 7 PY 2015 VL 118 IS 21 AR 214302 DI 10.1063/1.4936171 PG 9 WC Physics, Applied SC Physics GA DD4UK UT WOS:000369918100018 ER PT J AU DeCoste, JB Rossin, JA Peterson, GW AF DeCoste, Jared B. Rossin, Joseph A. Peterson, Gregory W. TI Hierarchical Pore Development by Plasma Etching of Zr-Based Metal-Organic Frameworks SO CHEMISTRY-A EUROPEAN JOURNAL LA English DT Article DE hierarchical porosity; mesoporous materials; metal-organic frameworks; plasma etching; UiO-66 ID POSTSYNTHETIC LIGAND; ROOM-TEMPERATURE; BUILDING UNIT; ADSORPTION; ZIRCONIUM; STABILITY; FUNCTIONALIZATION; DESTRUCTION; DEPOSITION; CATALYSIS AB The typically stable Zr-based metal-organic frameworks (MOFs) UiO-66 and UiO-66-NH2 were treated with tetrafluoromethane (CF4) and hexafluoroethane (C2F6) plasmas. Through interactions between fluoride radicals from the perfluoroalkane plasma and the zirconium-oxygen bonds of the MOF, the resulting materials showed the development of mesoporosity, creating a hierarchical pore structure. It is anticipated that this strategy can be used as a post-synthetic technique for developing hierarchical networks in a variety of MOFs. C1 [Peterson, Gregory W.] US Army, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 20101 USA. [DeCoste, Jared B.] Leidos Inc, Gunpowder, MD 21010 USA. [Rossin, Joseph A.] Guild Associates Inc, Dublin, OH 43228 USA. RP Peterson, GW (reprint author), US Army, Edgewood Chem Biol Ctr, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 20101 USA. EM gregory.w.peterson.civ@mail.mil FU Defense Threat Reduction Agency (DTRA) [BA07PRO104] FX G.W.P gratefully acknowledge the Defense Threat Reduction Agency (DTRA) for financial support under BA07PRO104. The authors thank the Walton Group at The Georgia Institute of Technology and David Britt at Lawrence Berkeley National Laboratory for providing UiO-66 and UiO-66-NH2, respectively. The authors also thank Shirmonda Smith and Bryan Schindler for collecting nitrogen-isotherm data, George Wagner, and Morgan Hall for collecting NMR data, and Erica Valdes for collecting EDS images. NR 39 TC 2 Z9 2 U1 18 U2 57 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 0947-6539 EI 1521-3765 J9 CHEM-EUR J JI Chem.-Eur. J. PD DEC 7 PY 2015 VL 21 IS 50 BP 18029 EP 18032 DI 10.1002/chem.201503632 PG 4 WC Chemistry, Multidisciplinary SC Chemistry GA CZ6BL UT WOS:000367186000003 PM 26443007 ER PT J AU Lee, AK Kulcsar, KA Elliott, O Khiabanian, H Nagle, ER Jones, MEB Amman, BR Sanchez-Lockhart, M Towner, JS Palacios, G Rabadan, R AF Lee, Albert K. Kulcsar, Kirsten A. Elliott, Oliver Khiabanian, Hossein Nagle, Elyse R. Jones, Megan E. B. Amman, Brian R. Sanchez-Lockhart, Mariano Towner, Jonathan S. Palacios, Gustavo Rabadan, Raul TI De novo transcriptome reconstruction and annotation of the Egyptian rousette bat SO BMC GENOMICS LA English DT Article DE RNA-seq; Transcriptome; Genomics; Annotation; Database ID RNA-SEQ DATA; BLACK FLYING FOX; FRUIT BATS; MARBURG VIRUS; EBOLA-VIRUS; NIPAH VIRUS; EXPERIMENTAL INOCULATION; PTEROPUS-POLIOCEPHALUS; EQUINE MORBILLIVIRUS; REFERENCE GENOME AB Background: The Egyptian Rousette bat (Rousettus aegyptiacus), a common fruit bat species found throughout Africa and the Middle East, was recently identified as a natural reservoir host of Marburg virus. With Ebola virus, Marburg virus is a member of the family Filoviridae that causes severe hemorrhagic fever disease in humans and nonhuman primates, but results in little to no pathological consequences in bats. Understanding host-pathogen interactions within reservoir host species and how it differs from hosts that experience severe disease is an important aspect of evaluating viral pathogenesis and developing novel therapeutics and methods of prevention. Results: Progress in studying bat reservoir host responses to virus infection is hampered by the lack of host-specific reagents required for immunological studies. In order to establish a basis for the design of reagents, we sequenced, assembled, and annotated the R. aegyptiacus transcriptome. We performed de novo transcriptome assembly using deep RNA sequencing data from 11 distinct tissues from one male and one female bat. We observed high similarity between this transcriptome and those available from other bat species. Gene expression analysis demonstrated clustering of expression profiles by tissue, where we also identified enrichment of tissue-specific gene ontology terms. In addition, we identified and experimentally validated the expression of novel coding transcripts that may be specific to this species. Conclusion: We comprehensively characterized the R. aegyptiacus transcriptome de novo. This transcriptome will be an important resource for understanding bat immunology, physiology, disease pathogenesis, and virus transmission. C1 [Lee, Albert K.; Rabadan, Raul] Columbia Univ Coll Phys & Surg, Dept Biomed Informat, New York, NY 10032 USA. [Lee, Albert K.; Elliott, Oliver; Khiabanian, Hossein; Rabadan, Raul] Columbia Univ Coll Phys & Surg, Dept Syst Biol, New York, NY 10032 USA. [Kulcsar, Kirsten A.; Nagle, Elyse R.; Sanchez-Lockhart, Mariano; Palacios, Gustavo] US Army, Med Res Inst Infect Dis, Ctr Genome Sci, Ft Detrick, MD 21702 USA. [Jones, Megan E. B.; Amman, Brian R.; Towner, Jonathan S.] Ctr Dis Control & Prevent, Viral Special Pathogens Branch, Atlanta, GA 30333 USA. [Palacios, Gustavo] George Mason Univ, Natl Ctr Biodef & Infect Dis, Manassas, VA 20110 USA. RP Rabadan, R (reprint author), Columbia Univ Coll Phys & Surg, Dept Biomed Informat, New York, NY 10032 USA. EM rr2579@cumc.columbia.edu RI Palacios, Gustavo/I-7773-2015; OI Palacios, Gustavo/0000-0001-5062-1938; Khiabanian, Hossein/0000-0003-1446-4394 FU Defense Threat Reduction Agency (DTRA) [HDTRA1-14-1-0016]; training program in computational biology [5T32GM082797-07] FX We thank Thomas Kepler, Stephanie D'Souza, Adam Hume, Elke Muhlberger, Jenna Kelly for comments and discussion on the project. We also thank Ahhyun Kim for the illustration of a bat in Fig 1a. This work was funded by the Defense Threat Reduction Agency (DTRA) grant HDTRA1-14-1-0016 and the training program in computational biology 5T32GM082797-07. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention or the U.S. Army. NR 50 TC 2 Z9 2 U1 4 U2 23 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2164 J9 BMC GENOMICS JI BMC Genomics PD DEC 7 PY 2015 VL 16 AR 1033 DI 10.1186/s12864-015-2124-x PG 11 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA CX6XI UT WOS:000365844600002 PM 26643810 ER PT J AU Rosenberg, YJ Adams, RJ Hernandez-Abanto, S Jiang, XM Sun, W Mao, LJ Lee, KD AF Rosenberg, Yvonne J. Adams, Robert J. Hernandez-Abanto, Segundo Jiang, Xiaoming Sun, Wei Mao, Lingjun Lee, K. David TI Pharmacokinetics and immunogenicity of a recombinant human butyrylcholinesterase bioscavenger in macaques following intravenous and pulmonary delivery SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article DE Human butyrylcholinesterase; Pharmacokinetics; Immunogenicity; Aerosol delivery; Monkey model; Animal Rule ID HUMAN SERUM BUTYRYLCHOLINESTERASE; N-GLYCOLYLNEURAMINIC ACID; PROTECTION; TOXICITY; ACETYLCHOLINESTERASE; MODEL; SOMAN; PRETREATMENT; STABILITY; PRODUCTS AB Recombinant (r) and native butyrylcholinesterse (BChE) are potent bioscavengers of organophosphates (OPs) such as nerve agents and pesticides and are undergoing development as antidotal treatments for OP-induced toxicity. Because of the lethal properties of such agents, regulatory approval will require extensive testing under the Animal Rule. However, human (Hu) glycoprotein biologicals, such as BChE, present a challenge for assessing immunogenicity and efficacy in heterologous animal models since any immune responses to the small species differences in amino acids or glycans between the host and biologic may alter pharmacodynamics and preclude accurate efficacy testing; possibly underestimating their potential protective value in humans. To establish accurate pharmacokinetic and efficacy data, an homologous animal model has been developed in which native and PEGylated forms of CHO-derived rMaBChE were multiply injected into homologous macaques with no induction of antibody. These now serve as controls for assessing the pharmacokinetics and immunogenicity in macaques of multiple administrations of PEGylated and unmodified human rBChE (rHuBChE) by both intravenous (IV) and pulmonary routes. The results indicate that, except for maximal concentration (Cmax), the pharmacokinetic parameters following IV injection with heterologous PEG-rHuBChE were greatly reduced even after the first injection compared with homologous PEG-rMaBChE. Anti-HuBChE antibody responses were induced in all monkeys after the second and third administrations regardless of the route of delivery; impacting rates of clearance and usually resulting in reduced endogenous MaBChE activity. These data highlight the difficulties inherent in assessing pharmacokinetics and immunogenicity in animal models, but bode well for the efficacy and safety of rHuBChE pretreatments in homologous humans. (C) 2015 Elsevier Ireland Ltd. All rights reserved. C1 [Rosenberg, Yvonne J.; Hernandez-Abanto, Segundo; Jiang, Xiaoming; Mao, Lingjun; Lee, K. David] PlantVax Inc, Rockville, MD 20850 USA. [Adams, Robert J.] Johns Hopkins Univ, Sch Med, Dept Mol & Comparat Pathobiol, Baltimore, MD 21205 USA. [Sun, Wei] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. RP Rosenberg, YJ (reprint author), PlantVax Inc, Rockville, MD 20850 USA. EM yjr@plantvax.com FU National Institutes of Health [U44 NS064608]; National Institute of Neurological Diseases and Stroke (NINDS) grants [U44NS064608]; Defense Threat Reduction Agency [HDTRA1-07-C-0023] FX This work was supported in part by the National Institutes of Health (U44 NS064608), National Institute of Neurological Diseases and Stroke (NINDS) grants #U44NS064608 and the Defense Threat Reduction Agency (#HDTRA1-07-C-0023). NR 31 TC 1 Z9 1 U1 2 U2 3 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 EI 1872-7786 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD DEC 5 PY 2015 VL 242 BP 219 EP 226 DI 10.1016/j.cbi.2015.09.021 PG 8 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA CZ7JI UT WOS:000367275300023 PM 26415620 ER PT J AU Omar, MY Xiang, CC Gupta, N Strbik, OM Cho, K AF Omar, Mohammed Yaseer Xiang, Chongchen Gupta, Nikhil Strbik, Oliver M., III Cho, Kyu TI Syntactic foam core metal matrix sandwich composite under bending conditions SO MATERIALS & DESIGN LA English DT Article DE Metal matrix composite; Sandwich composite; Syntactic foam; Flexural properties ID MINIMUM WEIGHT DESIGN; LOW-VELOCITY IMPACT; TENSILE-STRENGTH; STRAIN-RATES; BEAMS; COLLAPSE; FAILURE; PERFORMANCE; PANELS; DAMAGE AB The present work aims at characterizing a metal matrix syntactic foam core sandwich composite under three-point bending conditions. The sandwich comprises alumina hollow particle reinforced A356 alloy syntactic foam with carbon fabric skins. Crack initiation in the tensile side of the specimen causing failure of the skin, followed by rapid failure of the core in the direction applied load, is observed as the failure mechanism. Crack propagation through the alumina particles is observed in the failed specimens instead of interfacial failure. The average maximum strength, flexural strain and stiffness were measured as 91.2 +/- 5.6 MPa, 0.49 +/- 0.06% and 20.6 +/- 0.7 GPa respectively. The collapse load is theoretically predicted using mechanics of sandwich beams. Experimental values show good agreement with theoretical predictions. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Omar, Mohammed Yaseer; Xiang, Chongchen; Gupta, Nikhil] NYU, Polytech Sch Engn, Mech & Aerosp Engn Dept, Composite Mat & Mech Lab,MetroTech Ctr 6, Brooklyn, NY 11201 USA. [Strbik, Oliver M., III] Deep Springs Technol Inc, Toledo, OH 43615 USA. [Cho, Kyu] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Gupta, N (reprint author), NYU, Polytech Sch Engn, Mech & Aerosp Engn Dept, Composite Mat & Mech Lab,MetroTech Ctr 6, Brooklyn, NY 11201 USA. EM ngupta@nyu.edu OI gupta, nikhil/0000-0001-7128-4459 FU U.S. Army Research Laboratory contract of DST [W911NF-10-2-0084, W911NF-11-2-0096]; NYU; NSF [IIA-445686]; NYUAD Vice Chancellor's office FX This research is sponsored by the U.S. Army Research Laboratory contract W911NF-10-2-0084 of DST and the Cooperative Agreement W911NF-11-2-0096 with NYU. Partial support from NSF grant IIA-445686 is also acknowledged. The authors acknowledge scholarship from the NYUAD Vice Chancellor's office to Mohammed. Dr. Dung Dinh Luong and Steven E. Zeltmann are thanked for their help during the research work. NR 50 TC 4 Z9 4 U1 4 U2 24 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-1275 EI 1873-4197 J9 MATER DESIGN JI Mater. Des. PD DEC 5 PY 2015 VL 86 BP 536 EP 544 DI 10.1016/j.matdes.2015.07.127 PG 9 WC Materials Science, Multidisciplinary SC Materials Science GA CT5PO UT WOS:000362862700067 ER PT J AU Kumar, N Ying, Q Nie, X Mishra, RS Tang, Z Liaw, PK Brennan, RE Doherty, KJ Cho, KC AF Kumar, N. Ying, Q. Nie, X. Mishra, R. S. Tang, Z. Liaw, P. K. Brennan, R. E. Doherty, K. J. Cho, K. C. TI High strain-rate compressive deformation behavior of the Al0.1CrFeCoNi high entropy alloy SO MATERIALS & DESIGN LA English DT Article DE High entropy alloy; High strain-rate deformation; Twinning; Work hardening; Mechanical property; Split Hopkinson pressure bar ID MECHANICAL-PROPERTIES; PLASTIC-DEFORMATION; TENSILE PROPERTIES; STAINLESS-STEEL; MICROSTRUCTURE; EVOLUTION; SYSTEM; PHASE; AL0.1COCRFENI; STABILITY AB High entropy alloy is a new class of structural metallic materials. No work, so far, has been carried-out to understand high strain-rate plastic deformation behavior and resulting microstructure. This work focuses on understanding the deformation behavior of an Al0.1CrFeCoNi HEA at high strain-rate (HSR). HSR plastic deformation in compression mode was carried out using split-Hopkinson pressure bar. The pre- and post-deformation microstructures were studied using electron microscopes. A high strain-rate sensitivity of yield strength, significant work hardening, and profuse twinning are main characteristics observed during deformation of the alloy at HSR. Overall, the deformation behavior of the alloy was consistent with low stacking fault energy materials. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Kumar, N.; Mishra, R. S.] Univ N Texas, Dept Mat Sci & Engn, Ctr Frict Stir Proc, Denton, TX 76203 USA. [Ying, Q.; Nie, X.] Univ N Texas, Dept Mech & Energy Engn, Denton, TX 76203 USA. [Tang, Z.; Liaw, P. K.] Univ Tennessee, Dept Mat Sci & Engn, Knoxville, TN 37996 USA. [Brennan, R. E.; Doherty, K. J.; Cho, K. C.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Mishra, RS (reprint author), Univ N Texas, Dept Mat Sci & Engn, Ctr Frict Stir Proc, Denton, TX 76203 USA. EM Rajiv.Mishra@unt.edu RI Mishra, Rajiv/A-7985-2009 OI Mishra, Rajiv/0000-0002-1699-0614 FU Army Research Laboratory [W911NF-13-2-0018]; University of North Texas [W911NF-13-2-0018] FX The work was performed under a cooperative agreement between the Army Research Laboratory and the University of North Texas (W911NF-13-2-0018). The authors are also thankful to the Center for Advanced Research and Technology (CART) for providing access to the microscopy facilities at the University of North Texas. NR 34 TC 11 Z9 11 U1 13 U2 87 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-1275 EI 1873-4197 J9 MATER DESIGN JI Mater. Des. PD DEC 5 PY 2015 VL 86 BP 598 EP 602 DI 10.1016/j.matdes.2015.07.161 PG 5 WC Materials Science, Multidisciplinary SC Materials Science GA CT5PO UT WOS:000362862700074 ER PT J AU Meledeo, MA Rodriguez, AC Voelker, CR Bynum, JA Cap, AP AF Meledeo, Michael Adam Rodriguez, Armando C. Voelker, Chet R. Bynum, James A. Cap, Andrew P. TI In Vitro Assessment of Altered Thrombin-Fibrinogen Interaction As a Mechanism for Acute Traumatic Coagulopathy SO BLOOD LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Hematology CY DEC 05-08, 2015 CL Orlando, FL SP Amer Soc Hematol C1 [Meledeo, Michael Adam; Rodriguez, Armando C.; Voelker, Chet R.; Bynum, James A.] US Army, Inst Surg Res, San Antonio, TX USA. [Cap, Andrew P.] US Army Inst Surg Res, Coagulat & Blood Res, Jbsa Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA SN 0006-4971 EI 1528-0020 J9 BLOOD JI Blood PD DEC 3 PY 2015 VL 126 IS 23 PG 4 WC Hematology SC Hematology GA DA7XN UT WOS:000368019003199 ER PT J AU Nair, PM Dallo, S Cap, AP Ramasubramanian, AK AF Nair, Prajeeda M. Dallo, Shatha Cap, Andrew P. Ramasubramanian, Anand K. TI Cold-Stored Platelets in PAS Exhibit Superior Hemostatic Potential SO BLOOD LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Hematology CY DEC 05-08, 2015 CL Orlando, FL SP Amer Soc Hematol C1 [Nair, Prajeeda M.] Univ Texas San Antonio, Dept Biomed Engn, San Antonio, TX USA. [Nair, Prajeeda M.] Univ Texas Hlth Sci Ctr San Antonio, Dept Biomed Engn, San Antonio, TX 78229 USA. [Dallo, Shatha] Univ Texas San Antonio, San Antonio, TX USA. [Cap, Andrew P.] US Army Inst Surg Res, Coagulat & Blood Res, Jbsa Ft Sam Houston, TX USA. [Ramasubramanian, Anand K.] Univ Texas San Antonio, Biomed Engn, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA SN 0006-4971 EI 1528-0020 J9 BLOOD JI Blood PD DEC 3 PY 2015 VL 126 IS 23 PG 3 WC Hematology SC Hematology GA DA7XN UT WOS:000368019002209 ER PT J AU Salzer, W Burke, MJ Larsen, EC Chen, S Gore, L Hilden, JM Loh, ML Raetz, E Winick, NJ Carroll, WL Devidas, M Hunger, SP AF Salzer, Wanda Burke, Michael J. Larsen, Eric C. Chen, Si Gore, Lia Hilden, Joanne M. Loh, Mignon L. Raetz, Elizabeth Winick, Naomi J. Carroll, William L. Devidas, Meenakshi Hunger, Stephen P. TI Incidence of Allergic Reactions to Pegaspargase (PEG) Administered Intramuscularly Versus Intravenously (IM vs. IV) in Children and Young Adults with High Risk B-Lymphoblastic Leukemia (HR B-ALL): Results of Children's Oncology Group (COG) Studies AALL0232/AALL1131 SO BLOOD LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Hematology CY DEC 05-08, 2015 CL Orlando, FL SP Amer Soc Hematol C1 [Salzer, Wanda] US Army Med Res & Mat Command, Ft Detrick, MD USA. [Burke, Michael J.] Med Coll Wisconsin, Div Hematol Oncol Bone Marrow Transplantat, Milwaukee, WI 53226 USA. [Burke, Michael J.] Childrens Hosp Wisconsin, Milwaukee, WI 53201 USA. [Larsen, Eric C.] Maine Childrens Canc Program, Scarborough, ME USA. [Chen, Si; Devidas, Meenakshi] Univ Florida, Coll Med, Dept Biostat, Gainesville, FL USA. [Chen, Si; Devidas, Meenakshi] Univ Florida, Coll Publ Hlth, Dept Biostat, Gainesville, FL USA. [Chen, Si; Devidas, Meenakshi] Univ Florida, Coll Hlth Profess, Dept Biostat, Gainesville, FL USA. [Gore, Lia; Hilden, Joanne M.] Childrens Hosp Colorado, Ctr Canc & Blood Disorders, Aurora, CO USA. [Gore, Lia; Hilden, Joanne M.] Univ Colorado, Sch Med, Aurora, CO USA. [Loh, Mignon L.] Univ Calif San Francisco, Dept Pediat, Benioff Childrens Hosp, San Francisco, CA 94143 USA. [Raetz, Elizabeth] Univ Utah, Dept Pediat, Huntsman Canc Inst, Salt Lake City, UT USA. [Raetz, Elizabeth] Univ Utah, Primary Childrens Hosp, Salt Lake City, UT USA. [Winick, Naomi J.] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA. [Carroll, William L.] NYU, Med Ctr, Dept Pediat, Perlmutter Canc Ctr, New York, NY 10016 USA. [Hunger, Stephen P.] Childrens Hosp Philadelphia, Dept Pediat, Philadelphia, PA 19104 USA. [Hunger, Stephen P.] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA SN 0006-4971 EI 1528-0020 J9 BLOOD JI Blood PD DEC 3 PY 2015 VL 126 IS 23 PG 3 WC Hematology SC Hematology GA DA7XN UT WOS:000368019004103 ER PT J AU Bynum, JA Chance, T Meledeo, MA Pidcoke, HF AF Bynum, James A. Chance, Tiffani Meledeo, Michael Adam Pidcoke, Heather F. TI Gene Expression Profiling Reveals Key Mitochondrial Gene Changes in Stored Platelets SO BLOOD LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Hematology CY DEC 05-08, 2015 CL Orlando, FL SP Amer Soc Hematol C1 [Bynum, James A.; Meledeo, Michael Adam; Pidcoke, Heather F.] US Army, Inst Surg Res, San Antonio, TX USA. [Chance, Tiffani] Johns Hopkins Univ, Baltimore, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA SN 0006-4971 EI 1528-0020 J9 BLOOD JI Blood PD DEC 3 PY 2015 VL 126 IS 23 PG 3 WC Hematology SC Hematology GA DA7XY UT WOS:000368020105125 ER PT J AU Henderson, AT Mitchell, TA Cap, AP Herzig, MC Fedyk, CG AF Henderson, Aaron T. Mitchell, Thomas A. Cap, Andrew P. Herzig, Maryanne C. Fedyk, Chriselda G. TI Autotransfusion of Hemothorax Blood Is Prothrombotic but Inhibits Platelet Aggregation: A Potentiator of Disseminated Intravascular Coagulation SO BLOOD LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Hematology CY DEC 05-08, 2015 CL Orlando, FL SP Amer Soc Hematol C1 [Henderson, Aaron T.] San Antonio Mil Med Ctr, Hematol & Oncol, Ft Sam Houston, TX USA. [Mitchell, Thomas A.] San Antonio Mil Med Ctr, Gen Surg, San Antonio, TX USA. [Cap, Andrew P.; Herzig, Maryanne C.; Fedyk, Chriselda G.] US Army Inst Surg Res, Coagulat & Blood Res, Jbsa Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA SN 0006-4971 EI 1528-0020 J9 BLOOD JI Blood PD DEC 3 PY 2015 VL 126 IS 23 PG 3 WC Hematology SC Hematology GA DA7XY UT WOS:000368020101183 ER PT J AU Rabin, KR Hitzler, J Rodriguez, V Schore, R Angiolillo, A Burke, MJ Salzer, W Maloney, K Lu, XM Devidas, M Loh, ML Raetz, E Hunger, SP AF Rabin, Karen R. Hitzler, Johann Rodriguez, Vilmarie Schore, Reuven Angiolillo, Anne Burke, Michael J. Salzer, Wanda Maloney, Kelly Lu, Xiaomin Devidas, Meenakshi Loh, Mignon L. Raetz, Elizabeth Hunger, Stephen P. TI Treatment-Related Mortality (TRM) in Children with Down Syndrome (DS) and B-Lymphoblastic Leukemia (B-ALL): An Interim Report from the Children's Oncology Group Trials AALL0932 and AALL1131 SO BLOOD LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Hematology CY DEC 05-08, 2015 CL Orlando, FL SP Amer Soc Hematol C1 [Rabin, Karen R.] Baylor Coll Med, Hematol Oncol, Pediat, Houston, TX 77030 USA. [Hitzler, Johann] Hosp Sick Children, Dept Pediat, Div Hematol Oncol, Toronto, ON M5G 1X8, Canada. [Rodriguez, Vilmarie] Mayo Clin, Div Pediat Hematol & Oncol, Rochester, MN USA. [Schore, Reuven; Angiolillo, Anne] Childrens Natl Med Ctr, Washington, DC 20010 USA. [Burke, Michael J.] Med Coll Wisconsin, Div Hematol Oncol Bone Marrow Transplantat, Milwaukee, WI 53226 USA. [Burke, Michael J.] Childrens Hosp Wisconsin, Milwaukee, WI 53201 USA. [Salzer, Wanda] US Army Med Res & Mat Command, Ft Detrick, MD USA. [Maloney, Kelly] Childrens Hosp Colorado, Aurora, CO USA. [Lu, Xiaomin] Univ Florida, Dept Biostat, Gainesville, FL USA. [Devidas, Meenakshi] Univ Florida, Coll Med, Dept Biostat, Gainesville, FL USA. [Devidas, Meenakshi] Univ Florida, Coll Publ Hlth, Dept Biostat, Gainesville, FL USA. [Devidas, Meenakshi] Univ Florida, Coll Hlth Profess, Dept Biostat, Gainesville, FL USA. [Loh, Mignon L.] Univ Calif San Francisco, Dept Pediat, Benioff Childrens Hosp, San Francisco, CA USA. [Raetz, Elizabeth] Univ Utah, Dept Pediat, Huntsman Canc Inst, Salt Lake City, UT USA. [Raetz, Elizabeth] Univ Utah, Primary Childrens Hosp, Salt Lake City, UT USA. [Hunger, Stephen P.] Childrens Hosp Philadelphia, Dept Pediat, Philadelphia, PA 19104 USA. [Hunger, Stephen P.] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA SN 0006-4971 EI 1528-0020 J9 BLOOD JI Blood PD DEC 3 PY 2015 VL 126 IS 23 PG 3 WC Hematology SC Hematology GA DA7XY UT WOS:000368020102014 ER PT J AU Shaha, JS El-Othmani, MM Saleh, JK Bozic, KJ Wright, J Tokish, JM Shaha, SH Saleh, KJ AF Shaha, James S. El-Othmani, Mouhanad M. Saleh, Jamal K. Bozic, Kevin J. Wright, James Tokish, John M. Shaha, Steve H. Saleh, Khaled J. TI The Growing Gap in Electronic Medical Record Satisfaction Between Clinicians and Information Technology Professionals Issues of Most Concern and Suggested Remediations SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME LA English DT Article ID PHYSICIAN ORDER ENTRY; HEALTH RECORDS; PRIMARY-CARE; PATIENT; SYSTEM; IMPACT; IMPLEMENTATION; INTERVENTION; PREVENTION; HOSPITALS AB Background: With the alarming statistics concerning the quality of national health care, it is hoped that electronic health records (EHRs) will reduce inefficiencies associated with medical delivery and improve patient safety. This study reports the results of a survey that demonstrates a pattern in EHR system implementation that indicates that healthcare information technology decisions are based more on the preferences of information technology professionals (ITPs) and hospital administrators than clinicians. Methods: We present survey data highlighting the growing discrepancy in EHR-related satisfaction between clinicians and ITPs. We conducted a literature search to identify major barriers that must be overcome to achieve optimal EHR benefits. We summarize our recommendations in order to maximize the favorable impact of EHRs on the health-care system. Results: The existing gap in postimplementation EHR satisfaction ratings between ITPs and clinicians reveals an underlying systematic problem. Electronic medical record vendors perceive administrators and ITPs as the "buyers" for many EHR systems, and their needs are given higher priority than those of clinicians. This possibly may lead to the lack of clinically optimized EHRs, with systems often presenting as rigid and standardized with a limited exchange of health information. Conclusions: EHRs have the potential to become a powerful tool that may improve many processes related to health care, including quality, safety, and economical aspects. The involvement of physicians in every step of the process, from electronic medical record selection to acquisition, implementation, and ongoing optimization, is crucial for enabling the achievement of the medical organization's mission. C1 [Shaha, James S.; El-Othmani, Mouhanad M.; Saleh, Jamal K.; Bozic, Kevin J.; Wright, James; Tokish, John M.; Shaha, Steve H.; Saleh, Khaled J.] Tripler Army Med Ctr, Dept Orthopaed Surg, Honolulu, HI 96859 USA. RP Shaha, JS (reprint author), Tripler Army Med Ctr, Dept Orthopaed Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM ksaleh@siumed.edu OI El-Othmani, Mouhanad/0000-0001-7211-4072 NR 32 TC 1 Z9 1 U1 7 U2 12 PU JOURNAL BONE JOINT SURGERY INC PI NEEDHAM PA 20 PICKERING ST, NEEDHAM, MA 02192 USA SN 0021-9355 EI 1535-1386 J9 J BONE JOINT SURG AM JI J. Bone Joint Surg.-Am. Vol. PD DEC 2 PY 2015 VL 97A IS 23 BP 1979 EP 1984 DI 10.2106/JBJS.N.01118 PG 6 WC Orthopedics; Surgery SC Orthopedics; Surgery GA CY4TM UT WOS:000366401300014 PM 26632000 ER PT J AU Poly, F Serichantalergs, O Kuroiwa, J Pootong, P Mason, C Guerry, P Parker, CT AF Poly, Frederic Serichantalergs, Oralak Kuroiwa, Janelle Pootong, Piyarat Mason, Carl Guerry, Patricia Parker, Craig T. TI Updated Campylobacter jejuni Capsule PCR Multiplex Typing System and Its Application to Clinical Isolates from South and Southeast Asia SO PLOS ONE LA English DT Article ID POLYSACCHARIDE CONJUGATE VACCINE; IRRITABLE-BOWEL-SYNDROME; GENOME SEQUENCE; DIVERSITY; SEROTYPE; IDENTIFICATION; OUTBREAK; CHILDREN; THAILAND; STRAIN AB Campylobacter jejuni produces a polysaccharide capsule that is the major determinant of the Penner serotyping scheme. This passive slide agglutination typing system was developed in the early 1980's and was recognized for over two decades as the gold standard for C. jejuni typing. A preliminary multiplex PCR technique covering 17 serotypes was previously developed in order to replace this classic serotyping scheme. Here we report the completion of the multiplex PCR technology that is able to identify all the 47 Penner serotypes types known for C. jejuni. The number of capsule types represented within the 47 serotypes is 35. We have applied this method to a collection of 996 clinical isolates from Thailand, Cambodia and Nepal and were able to successfully determine capsule types of 98% of these. C1 [Poly, Frederic; Kuroiwa, Janelle; Guerry, Patricia] Naval Med Res Ctr, Enter Dis Dept, Silver Spring, MD 20910 USA. [Serichantalergs, Oralak; Pootong, Piyarat; Mason, Carl] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Parker, Craig T.] ARS, USDA, Albany, CA USA. RP Poly, F (reprint author), Naval Med Res Ctr, Enter Dis Dept, Silver Spring, MD 20910 USA. EM frederic.m.poly.ctr@mail.mil OI MASON, CARL/0000-0002-3676-2811 FU U.S. Naval Medical Research and Development Command Work Unit [6000.RAD1.DA3.A0308]; US department of agriculture-Agricultural Research Service [CRIS 5325-42000-047]; Military Infectious Diseases Research Program, Walter Reed Army Institute of Research, Washington, DC FX This work was supported by U.S. Naval Medical Research and Development Command Work Unit 6000.RAD1.DA3.A0308 (FP JK PP PG). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. US department of agriculture-Agricultural Research Service, CRIS 5325-42000-047 (CTP). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Military Infectious Diseases Research Program, Walter Reed Army Institute of Research, Washington, DC (OS PP CM). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 45 TC 2 Z9 2 U1 0 U2 1 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 2 PY 2015 VL 10 IS 12 AR e0144349 DI 10.1371/journal.pone.0144349 PG 17 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CX8BI UT WOS:000365926300181 PM 26630669 ER PT J AU Gong, C Ruzmetov, D Pearse, A Ma, DK Munday, JN Rubloff, G Talin, AA Leite, MS AF Gong, Chen Ruzmetov, Dmitry Pearse, Alexander Ma, Dakang Munday, Jeremy N. Rubloff, Gary Talin, A. Alec Leite, Marina S. TI Surface/Interface Effects on High-Performance Thin-Film All-Solid-State Li-Ion Batteries SO ACS APPLIED MATERIALS & INTERFACES LA English DT Article DE energy storage; all-solid-state batteries; thin-films; aluminum; silicon ID TRANSMISSION ELECTRON-MICROSCOPY; ELECTROCHEMICAL PERFORMANCE; LITHIUM BATTERIES; ANODES; SILICON; LITHIATION; STABILITY; OXIDATION; ALUMINUM; CARBON AB The further development of all-solid-state batteries is still limited by the understanding/engineering of the interfaces formed upon cycling. Here, we correlate the morphological, chemical, and electrical changes of the surface of thin-film devices with Al negative electrodes. The stable Al-Li-O alloy formed at the stress-free surface of the electrode causes rapid capacity fade, from 48.0 to 41.5 mu Ah/cm(2) in two cycles. Surprisingly, the addition of a Cu capping layer is insufficient to prevent the device degradation. Nevertheless, Si electrodes present extremely stable cycling, maintaining >92% of its capacity after 100 cycles, with average Coulombic efficiency of 98%. C1 [Gong, Chen; Leite, Marina S.] Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA. [Gong, Chen; Pearse, Alexander; Ma, Dakang; Munday, Jeremy N.; Rubloff, Gary; Leite, Marina S.] Univ Maryland, Inst Res Elect & Appl Phys, College Pk, MD 20742 USA. [Ma, Dakang; Munday, Jeremy N.] Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA. [Rubloff, Gary] Univ Maryland, Syst Res Inst, College Pk, MD 20742 USA. [Ruzmetov, Dmitry] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. [Ruzmetov, Dmitry] NIST, Mat Measurement Lab, Gaithersburg, MD 20899 USA. [Talin, A. Alec] Sandia Natl Labs, Livermore, CA 94550 USA. RP Leite, MS (reprint author), Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA. EM aatalin@sandia.gov; mleite@umd.edu RI Munday, Jeremy/E-6512-2016; Gong, Chen/R-9309-2016; Pearse, Alexander/B-2792-2017 OI Munday, Jeremy/0000-0002-0881-9876; Gong, Chen/0000-0003-3302-7675; FU School of Engineering at the University of Maryland; Minta Martin Award; Laboratory Directed Research and Development Program at Sandia National Laboratories; U.S. DOE National Nuclear Security Administration [DE-AC04-94AL85000]; U.S. Department of Energy, Office of Science, and Office of Basic Energy Sciences [DESC0001160] FX MSL and JNM thank the financial support from the School of Engineering at the University of Maryland, and the Minta Martin Award. CG acknowledge the University of Maryland 2015 Graduate School's Summer Research Fellowship program. This work was partially supported by the Laboratory Directed Research and Development Program at Sandia National Laboratories. Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the U.S. DOE National Nuclear Security Administration under Contract DE-AC04-94AL85000. Nanostructures for Electrical Energy Storage (NEES), an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science, and Office of Basic Energy Sciences under award DESC0001160, provided partial support to AAT and GR for data analysis and manuscript authoring, and to AP for carrying out XPS experiments and analysis. NR 30 TC 4 Z9 4 U1 19 U2 121 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1944-8244 J9 ACS APPL MATER INTER JI ACS Appl. Mater. Interfaces PD DEC 2 PY 2015 VL 7 IS 47 BP 26007 EP 26011 DI 10.1021/acsami.5b07058 PG 5 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA CX8DB UT WOS:000365931700001 PM 26436529 ER PT J AU Chaorattanakawee, S Lanteri, CA Sundrakes, S Yingyuen, K Gosi, P Chanarat, N Wongarunkochakorn, S Buathong, N Chann, S Kuntawunginn, W Arsanok, M Lin, JT Juliano, JJ Tyner, SD Char, M Lon, C Saunders, DL AF Chaorattanakawee, Suwanna Lanteri, Charlotte A. Sundrakes, Siratchana Yingyuen, Kritsanai Gosi, Panita Chanarat, Nitima Wongarunkochakorn, Saowaluk Buathong, Nillawan Chann, Soklyda Kuntawunginn, Worachet Arsanok, Montri Lin, Jessica T. Juliano, Jonathan J. Tyner, Stuart D. Char, Mengchuor Lon, Chanthap Saunders, David L. TI Attenuation of Plasmodium falciparum in vitro drug resistance phenotype following culture adaptation compared to fresh clinical isolates in Cambodia SO MALARIA JOURNAL LA English DT Article DE Malaria; In vitro drug susceptibility; Culture adaptation; Cambodia ID POPULATION-DYNAMICS; MALARIA PARASITES; SENSITIVITY; ASSAY; SUSCEPTIBILITY; ARTEMISININ; INVITRO; WESTERN; INFECTIONS; MUTATIONS AB Background: There is currently no standardized approach for assessing in vitro anti-malarial drug susceptibility. Potential alterations in drug susceptibility results between fresh immediate ex vivo (IEV) and cryopreserved culture-adapted (CCA) Plasmodium falciparum isolates, as well as changes in parasite genotype during culture adaptation were investigated. Methods: The 50 % inhibitory concentration (IC50) of 12 P. falciparum isolates from Cambodia against a panel of commonly used drugs were compared using both IEV and CCA. Results were compared using both histidine-rich protein-2 ELISA (HRP-2) and SYBR-Green I fluorescence methods. Molecular genotyping and amplicon deep sequencing were also used to compare multiplicity of infection and genetic polymophisms in fresh versus culture-adapted isolates. Results: IC50 for culture-adapted specimens were significantly lower compared to the original fresh isolates for both HRP-2 and SYBR-Green I assays, with greater than a 50 % decline for the majority of drug-assay combinations. There were correlations between IC(50)s from IEV and CCA for most drugs assays. Infections were nearly all monoclonal, with little or no change in merozoite surface protein 1 (MSP1), MSP2, glutamate-rich protein (GLURP) or apical membrane antigen 1 (AMA1) polymorphisms, nor differences in P. falciparum multidrug resistance 1 gene (PfMDR1) copy number or single nucleotide polymorphisms following culture adaptation. Conclusions: The overall IC50 reduction combined with the correlation between fresh isolates and culture-adapted drug susceptibility assays suggests the utility of both approaches, as long as there is consistency of method, and remaining mindful of possible attenuation of resistance phenotype occurring in culture. Further study should be done in higher transmission settings where polyclonal infections are prevalent. C1 [Chaorattanakawee, Suwanna; Lanteri, Charlotte A.; Sundrakes, Siratchana; Yingyuen, Kritsanai; Gosi, Panita; Chanarat, Nitima; Wongarunkochakorn, Saowaluk; Buathong, Nillawan; Chann, Soklyda; Kuntawunginn, Worachet; Arsanok, Montri; Tyner, Stuart D.; Lon, Chanthap; Saunders, David L.] Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand. [Lin, Jessica T.; Juliano, Jonathan J.] Univ N Carolina, Sch Med, Div Infect Dis, Chapel Hill, NC USA. [Char, Mengchuor] Natl Ctr Parasitol Entomol & Malaria Control, Phnom Penh, Cambodia. RP Lon, C (reprint author), Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand. EM ChanthapL@afrims.org FU Global Emerging Infections Surveillance (GEIS) Program, US Department of Defense FX We are grateful to the AFRIMS and Cambodian clinical and laboratory field teams for conducting microscopy and their technical support. We thank Mr. William Ellis at the Walter Reed Army Institute of Research (WRAIR) for providing us with test drugs. This work was funded by the Global Emerging Infections Surveillance (GEIS) Program, US Department of Defense. NR 33 TC 2 Z9 2 U1 0 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD DEC 2 PY 2015 VL 14 AR 486 DI 10.1186/s12936-015-1021-8 PG 7 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA CX6FE UT WOS:000365795800001 PM 26626127 ER PT J AU Ma, R Ferris, JB Reid, AA Gorsich, DJ AF Ma, Rui Ferris, John B. Reid, Alexander A. Gorsich, David J. TI A planar quasi-static constraint mode tyre model SO VEHICLE SYSTEM DYNAMICS LA English DT Article DE terrain surface; road surface; tyre force estimation; planar tyre model; constraint mode ID SYSTEMS; FORCES AB The fast-paced, iterative, vehicle design environment demands efficiency when simulating suspension loads. Towards that end, a computationally efficient, linear, planar, quasi-static tyre model is developed in this work that accurately predicts a tyre's lower frequency, reasonably large amplitude, nonlinear stiffness relationship. The axisymmetric, circumferentially isotropic, stiffness equation is discretised into segments, then parameterised by a single stiffness parameter and two shape parameters. The tyre's deformed shape is independent of the overall tyre stiffness and the forces acting on the tyre. Constraint modes capture enveloping and bridging properties and a recursive method yields the set of active constraints at the tyre-road interface. The nonlinear stiffness of a tyre is captured by enforcing unidirectional geometric boundary conditions. The model parameters are identified semi-empirically; simulated cleat test loads match experiments within 7% including nonlinear stiffness when simulating a flat plate test and a discontinuous stiffness when simulating a cleat test. C1 [Ma, Rui; Ferris, John B.] Virginia Tech, Dept Mech Engn, Blacksburg, VA 24061 USA. [Reid, Alexander A.; Gorsich, David J.] US Army Tank Automot Res, Dev & Engn Ctr TARDEC, Warren, MI USA. RP Ferris, JB (reprint author), Virginia Tech, Dept Mech Engn, Blacksburg, VA 24061 USA. EM jbferris@vt.edu FU Automotive Research Center (ARC), a U.S. Army Center of Excellence FX This work was supported by the Automotive Research Center (ARC), a U.S. Army Center of Excellence in modelling and simulation of ground vehicles. NR 14 TC 0 Z9 0 U1 1 U2 5 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0042-3114 EI 1744-5159 J9 VEHICLE SYST DYN JI Veh. Syst. Dyn. PD DEC 2 PY 2015 VL 53 IS 12 BP 1759 EP 1771 DI 10.1080/00423114.2015.1088161 PG 13 WC Engineering, Mechanical SC Engineering GA CX4ZO UT WOS:000365709800005 ER PT J AU Burkhard, P Lanar, DE AF Burkhard, Peter Lanar, David E. TI Malaria vaccine based on self-assembling protein nanoparticles SO EXPERT REVIEW OF VACCINES LA English DT Editorial Material DE malaria; nanoparticle; Plasmodium falciparum; SAPN; vaccine ID PEPTIDE NANOPARTICLES; FALCIPARUM-MALARIA; PHASE-3 TRIAL; PROTECTION; CHILDREN; PLATFORM; DISPLAY; DESIGN AB Despite recent progress with GSK's RTS,S malaria vaccine, there remains a desperate need for an efficient malaria vaccine. We have used a repetitive antigen display technology to display malaria specific B cell and T cell epitopes in an effort to design a vaccine against Plasmodium falciparum malaria. Our protein sequence when assembled into a nanoparticle induces strong, long-lived and protective immune responses against infection with the parasite. We are confident that the clinical trials with our most developed vaccine candidate will show good protection in a controlled human malaria infection trial. C1 [Burkhard, Peter] Univ Connecticut, Inst Mat Sci, Storrs, CT 06269 USA. [Burkhard, Peter] Univ Connecticut, Dept Mol & Cell Biol, Storrs, CT 06269 USA. [Lanar, David E.] Walter Reed Army Inst Res, Malaria Vaccine Branch, Silver Spring, MD 20910 USA. RP Burkhard, P (reprint author), Univ Connecticut, Inst Mat Sci, Storrs, CT 06269 USA. EM peter.burkhard@uconn.edu FU NIAID NIH HHS [5R01AI068761, R01 AI068761] NR 20 TC 5 Z9 5 U1 2 U2 16 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1476-0584 EI 1744-8395 J9 EXPERT REV VACCINES JI Expert Rev. Vaccines PD DEC 2 PY 2015 VL 14 IS 12 BP 1525 EP 1527 DI 10.1586/14760584.2015.1096781 PG 3 WC Immunology SC Immunology GA CV7XW UT WOS:000364491500001 PM 26468608 ER PT J AU Popham, DL Bernhards, CB AF Popham, David L. Bernhards, Casey B. TI Spore Peptidoglycan SO MICROBIOLOGY SPECTRUM LA English DT Article ID CORTEX-LYTIC ENZYME; CLOSTRIDIUM-PERFRINGENS S40; PENICILLIN-BINDING PROTEIN; BACILLUS-SUBTILIS SPORES; WALL HYDROLASE GENE; NUCLEOTIDE-SEQUENCE; HEAT-RESISTANCE; BACTERIAL-SPORES; MOLECULAR CHARACTERIZATION; STRUCTURAL-ANALYSIS AB Bacterial endospores possess multiple integument layers, one of which is the cortex peptidoglycan wall. The cortex is essential for the maintenance of spore core dehydration and dormancy and contains structural modifications that differentiate it from vegetative cell peptidoglycan and determine its fate during spore germination. Following the engulfment stage of sporulation, the cortex is synthesized within the intermembrane space surrounding the forespore. Proteins responsible for cortex synthesis are produced in both the forespore and mother cell compartments. While some of these proteins also contribute to vegetative cell wall synthesis, others are sporulation specific. In order for the bacterial endospore to germinate and resume metabolism, the cortex peptidoglycan must first be degraded through the action of germination-specific lytic enzymes. These enzymes are present, yet inactive, in the dormant spore and recognize the muramic-delta-lactam modification present in the cortex. Germination-specific lytic enzymes across Bacillaceae and Clostridiaceae share this specificity determinant, which ensures that the spore cortex is hydrolyzed while the vegetative cell wall remains unharmed. Bacillus species tend to possess two redundant enzymes, SleB and CwlJ, capable of sufficient cortex degradation, while the clostridia have only one, SleC. Additional enzymes are often present that cannot initiate the cortex degradation process, but which can increase the rate of release of small fragments into the medium. Between the two families, the enzymes also differ in the enzymatic activities they possess and the mechanisms acting to restrict their activation until germination has been initiated. C1 [Popham, David L.] Virginia Tech, Dept Biol Sci, Life Sci 1, Blacksburg, VA 24061 USA. [Bernhards, Casey B.] US Army, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Popham, DL (reprint author), Virginia Tech, Dept Biol Sci, Life Sci 1, Blacksburg, VA 24061 USA. EM dpopham@vt.edu OI Popham, David/0000-0002-2614-143X NR 138 TC 1 Z9 1 U1 2 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA EI 2165-0497 J9 MICROBIOL SPECTR JI Microbiol. Spectr. PD DEC PY 2015 VL 3 IS 6 AR UNSP TBS-0005-2012 DI 10.1128/microbiolspec.TBS-0005-2012 PG 20 WC Microbiology SC Microbiology GA DT9FD UT WOS:000381800300009 ER PT J AU Koppenhaver, SL Walker, MJ Su, J McGowen, JM Umlauf, L Harris, KD Ross, MD AF Koppenhaver, Shane L. Walker, Michael J. Su, Jonathan McGowen, Jared M. Umlauf, Lindsey Harris, Kevin D. Ross, Michael D. TI Changes in lumbar multifidus muscle function and nociceptive sensitivity in low back pain patient responders versus non-responders after dry needling treatment SO MANUAL THERAPY LA English DT Article DE Acupuncture; Low back pain; Muscle contraction; Ultrasonography ID MYOFASCIAL TRIGGER POINT; NECK PAIN; TRANSVERSUS ABDOMINIS; SPINAL MANIPULATION; PRESSURE ALGOMETRY; CLINICAL-TRIAL; IRRITABILITY; ACUPUNCTURE; RELIABILITY; MANAGEMENT AB Background: Little is known about the physiologic mechanism of dry needling. While some evidence suggests that dry needling may decrease nocioceptive sensitivity and facilitate muscle function, no studies to date have examined these physiologic changes compared to clinical outcomes. Objective: To examine changes in lumbar multifidus (LM) muscle function and nociceptive sensitivity after dry needling in patients with LBP and to determine if such changes differ in patients that exhibit improved disability (responders) and those that do not (non-responders). Design: Quasi-experimental study. Methods: Sixty-six volunteers with mechanical LBP (38 men, age = 41.3 +/- 9.2 years) completed the study. Ultrasound measurements and pain algometry of the LM were taken at baseline and repeated immediately following dry needling treatment to the LM muscles and after one week. The percent change in muscle thickness from rest to contraction was calculated for each time point to represent muscle function. Pressure pain threshold (PPT) was used to measure nociceptive sensitivity. Participants were dichotomized as responders and non-responders based on whether or not they experienced clinical improvement using the modified Oswestry Disability Index after one week. 2 x 3 mixed-model ANOVA were conducted for group (responders vs. non-responders) by time. Results: Patient responders exhibited larger improvements in LM muscle contraction and nociceptive sensitivity 1 week, but not immediately, after dry needling than non-responders. Conclusions: Our results suggest that there may be lasting and clinically relevant sensorimotor changes that occur in LBP patients that improve with dry needling treatment that partially explain the physiologic mechanism of action. Published by Elsevier Ltd. C1 [Koppenhaver, Shane L.; Walker, Michael J.; Su, Jonathan; McGowen, Jared M.; Umlauf, Lindsey] US Army Baylor Univ, Doctoral Program Phys Therapy, San Antonio, TX USA. [Harris, Kevin D.] Guthrie Ambulatory Hlth Clin, Dept Rehabil, Ft Drum, NY USA. [Ross, Michael D.] Univ Scranton, Dept Phys Therapy, Scranton, PA 18510 USA. RP Koppenhaver, SL (reprint author), US Army Baylor Univ, Doctoral Program Phys Therapy, San Antonio, TX USA. EM shanekoppenhaver@mac.com NR 43 TC 1 Z9 1 U1 2 U2 7 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND SN 1356-689X EI 1532-2769 J9 MANUAL THER JI Man. Ther. PD DEC PY 2015 VL 20 IS 6 BP 769 EP 776 DI 10.1016/j.math.2015.03.003 PG 8 WC Rehabilitation SC Rehabilitation GA DG6LP UT WOS:000372196300013 PM 25801100 ER PT J AU Hoover, JJ Katzenmeyer, AW Collins, J Lewis, BR Slack, WT George, SG AF Hoover, Jan Jeffrey Katzenmeyer, Alan W. Collins, Jay Lewis, Bradley R. Slack, W. Todd George, Steven G. TI Age and Reproductive Condition of an Unusually Large Bighead Carp from the Lower Mississippi River Basin SO SOUTHEASTERN NATURALIST LA English DT Article ID MISSOURI RIVER; SILVER CARP; HYPOPHTHALMICHTHYS-NOBILIS; ASIAN CARP; GROWTH AB On 24 February 2014, commercial fishers caught an unusually large Hypophthalmichthys nobilis (Bighead Carp) from an oxbow lake in northwestern Mississippi. We examined it to determine age, gonadal development, and fecundity. The specimen was 1316 mm total length, 49.7 kg, and 11 years old. It had asymmetric ovaries that collectively represented 15.7% of the body weight, with an estimated 1.9 to 2.7 million eggs, similar to 40% of which were mature. The data we collected for size, age, and fecundity were all at or near maximum values known for the species. This specimen demonstrates that for life-history studies and demographic models to be representative of introduced populations, rare or hard-to-catch large specimens are required due to their influence on estimates of longevity, mortality, and fecundity. C1 [Hoover, Jan Jeffrey; Katzenmeyer, Alan W.; Collins, Jay; Lewis, Bradley R.; Slack, W. Todd; George, Steven G.] US Army Engineer Res & Dev Ctr, EE A, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. RP Hoover, JJ (reprint author), US Army Engineer Res & Dev Ctr, EE A, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Jan.J.Hoover@usace.army.mil FU Aquatic Nuisance Species Research Program FX The Mississippi Department of Wildlife Fisheries and Parks invited us to participate in fieldwork and provided assistance; Garry Lucas (retired) and Larry Pugh (chief) provided data on Paddlefish populations. James P. Parker and Walter Ray collected the Bighead Carp and brought it to us. Glenn Parsons and Bryan Cage assisted in the field. The Aquatic Nuisance Species Research Program provides funds for our Asian Carp research. The Chief of Engineers approved this paper for publication. Our thanks to all of the people and agencies mentioned above. NR 19 TC 0 Z9 0 U1 13 U2 15 PU HUMBOLDT FIELD RESEARCH INST PI STEUBEN PA PO BOX 9, STEUBEN, ME 04680-0009 USA SN 1528-7092 EI 1938-5412 J9 SOUTHEAST NAT JI Southeast. Nat. PD DEC PY 2015 VL 14 IS 4 BP N55 EP N60 DI 10.1656/058.014.0411 PG 6 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA DE8NL UT WOS:000370892600017 ER PT J AU Zubko, E Videen, G Hines, DC Shkuratov, Y Kaydash, V Muinonen, K Knight, MM Sitko, ML Lisse, CM Mutchler, M Wooden, DH Li, JY Kobayashi, H AF Zubko, Evgenij Videen, Gorden Hines, Dean C. Shkuratov, Yuriy Kaydash, Vadym Muinonen, Karri Knight, Matthew M. Sitko, Michael L. Lisse, Carey M. Mutchler, Max Wooden, Diane H. Li, Jian-Yang Kobayashi, Hiroshi TI Cornet C/2012 S1 (ISON) coma composition at similar to 4 au from HST observations SO PLANETARY AND SPACE SCIENCE LA English DT Article ID O1 HALE-BOPP; HUBBLE-SPACE-TELESCOPE; OPTICAL-CONSTANTS; COMETARY DUST; IMAGING POLARIMETRY; SILICATE MINERALOGY; REFRACTIVE-INDEXES; INFRARED-SPECTRA; LIGHT-SCATTERING; 81P/WILD-2 DUST AB We analyze the first color and polarization images of Comet ISON (C/2012 S1) taken during two measurement campaigns of the Hubble Space Telescope (HST) on UTC 2013 April 10 and May 8, when the phase angles of Comet ISON were alpha approximate to 13.7 degrees and 12.2 degrees, respectively. We model the particles in the coma using highly irregular agglomerated debris particles. Even though the observations were made over a small range of phase angle, the data still place significant constraints on the material properties of the cometary coma. The different photo-polarimetric responses are indicative of spatial chemical heterogeneity of coma in Comet ISON. For instance, at small projected distances to the nucleus (< 500 km), our modeling suggests the cometary particles are composed predominantly of small, highly absorbing particles, such as amorphous carbon and/or organics material heavily irradiated with UV radiation; whereas, at longer projected distances (> 1000 km), the refractive index of the particles is consistent with organic matter slightly processed with UV radiation, tholins, Mg-Fe silicates, and/or Mg-rich silicates contaminated with similar to 10% (by volume) amorphous carbon. The modeling suggests low relative abundances of particles with low material absorption in the visible, i.e., Im(m) <= 0.02. Such particles were detected unambiguously in other comets in the vicinity of nucleus through very strong negative polarization near backscattering (P approximate to -6%) and very low positive polarization (P approximate to 3-5%) at side scattering. These materials were previously attributed to Mg-rich silicates forming a refractory surface layer on the surface of cometary nuclei (Zubko et al., 2012). The absence of such particles in Comet ISON could imply an absence of such a layer on its nucleus. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Zubko, Evgenij; Shkuratov, Yuriy; Kaydash, Vadym] Kharkov Natl Univ, Inst Astron, 35 Sumskaya St, UA-61022 Kharkov, Ukraine. [Videen, Gorden; Hines, Dean C.; Sitko, Michael L.] Space Sci Inst, Boulder, CO 80301 USA. [Videen, Gorden; Mutchler, Max] INTA, Madrid 28850, Spain. [Videen, Gorden] Univ Cantabria, Fac Ciencias, Dept Fis Aplicada, Grp Opt, E-39005 Santander, Spain. [Videen, Gorden] US Army Res Lab, Adelphi, MD 20783 USA. [Hines, Dean C.] Space Telescope Sci Inst, Baltimore, MD 21218 USA. [Muinonen, Karri] Univ Helsinki, Dept Phys, FIN-00014 Helsinki, Finland. [Muinonen, Karri] Finnish Geospatial Res Inst, FI-02431 Masala, Finland. [Knight, Matthew M.] Lowell Observ, Flagstaff, AZ 86001 USA. [Knight, Matthew M.; Lisse, Carey M.] Johns Hopkins Univ, Appl Phys Lab, Laurel, MD 20723 USA. [Sitko, Michael L.] Univ Cincinnati, Dept Phys, Cincinnati, OH 45221 USA. [Wooden, Diane H.] NASA Ames Res Ctr, Mountain View, CA USA. [Li, Jian-Yang] Planetary Sci Inst, Tucson, AZ 85719 USA. [Kobayashi, Hiroshi] Nagoya Univ, Chikusa Ku, Nagoya, Aichi 4648602, Japan. RP Zubko, E (reprint author), Kharkov Natl Univ, Inst Astron, 35 Sumskaya St, UA-61022 Kharkov, Ukraine. EM evgenij.s.zubko@gmail.com RI Lisse, Carey/B-7772-2016; OI Lisse, Carey/0000-0002-9548-1526; Zubko, Evgenij/0000-0001-9994-923X FU NASA from Space Telescope Science Institute [GO 13199]; NASA [NAS5-26555] FX This work was partially supported through program number GO 13199 provided by NASA through a grant from the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS5-26555. NR 86 TC 4 Z9 4 U1 0 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0032-0633 J9 PLANET SPACE SCI JI Planet Space Sci. PD DEC 1 PY 2015 VL 118 SI SI BP 138 EP 163 DI 10.1016/j.pss.2015.08.002 PG 26 WC Astronomy & Astrophysics SC Astronomy & Astrophysics GA DE2LZ UT WOS:000370460100018 ER PT J AU Lovely, A Loose, B Schlosser, P McGillis, W Zappa, C Perovich, D Brown, S Morell, T Hsueh, D Friedrich, R AF Lovely, A. Loose, B. Schlosser, P. McGillis, W. Zappa, C. Perovich, D. Brown, S. Morell, T. Hsueh, D. Friedrich, R. TI The Gas Transfer through Polar Sea ice experiment: Insights into the rates and pathways that determine geochemical fluxes SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article DE polar ocean; sea ice; gas exchange; carbon cycle; climate change; Arctic ID EXCHANGE; WATER; DIFFUSION; CO2; SOLUBILITY; SEAWATER; OCEAN; COEFFICIENTS; PERCOLATION; ANTARCTICA AB Sea ice is a defining feature of the polar marine environment. It is a critical domain for marine biota and it regulates ocean-atmosphere exchange, including the exchange of greenhouse gases such as CO2 and CH4. In this study, we determined the rates and pathways that govern gas transport through a mixed sea ice cover. N2O, SF6, He-3, He-4, and Ne were used as gas tracers of the exchange processes that take place at the ice-water and air-water interfaces in a laboratory sea ice experiment. Observation of the changes in gas concentrations during freezing revealed that He is indeed more soluble in ice than in water; Ne is less soluble in ice, and the larger gases (N2O and SF6) are mostly excluded during the freezing process. Model estimates of gas diffusion through ice were calibrated using measurements of bulk gas content in ice cores, yielding gas transfer velocity through ice (k(ice)) of approximate to 5 x 10(-4) m d(-1). In comparison, the effective air-sea gas transfer velocities (k(eff)) ranged up to 0.33 m d(-1) providing further evidence that very little mixed-layer ventilation takes place via gas diffusion through columnar sea ice. However, this ventilation is distinct from air-ice gas fluxes driven by sea ice biogeochemistry. The magnitude of k(eff) showed a clear increasing trend with wind speed and current velocity beneath the ice, as well as the combination of the two. This result indicates that gas transfer cannot be uniquely predicted by wind speed alone in the presence of sea ice. C1 [Lovely, A.; Loose, B.] Univ Rhode Isl, Grad Sch Oceanog, Narragansett, RI 02882 USA. [Schlosser, P.; Zappa, C.] Columbia Univ, Dept Earth & Environm Sci, Palisades, NY USA. [Schlosser, P.; McGillis, W.] Columbia Univ, Dept Earth & Environm Engn, New York, NY USA. [Schlosser, P.; McGillis, W.; Zappa, C.; Brown, S.; Morell, T.; Hsueh, D.] Columbia Univ, Lamont Doherty Geol Observ, Palisades, NY 10964 USA. [Perovich, D.] US Army Corps Engineers Cold Reg Res & Engn Lab, Hanover, NH USA. [Friedrich, R.] Heidelberg Univ, Inst Environm Phys, Heidelberg, Germany. RP Loose, B (reprint author), Univ Rhode Isl, Grad Sch Oceanog, Narragansett, RI 02882 USA. EM brice@gso.uri.edu FU Foundation of the University of Rhode Island; Tabor Academy; NSF [ANT 09-44643] FX The authors thank Leonard Zabilansky, Thomas Tantillo, Gordon Gooch, and the rest of the amazing engineering staff at CRREL. We thank Dennis Graham at URI GSO for analyzing samples for DIC and alkalinity. Support for A. Lovely was provided by the Foundation of the University of Rhode Island and by Tabor Academy. Funding support for GAPS and for B. Loose, P. Schlosser, C. J. Zappa, W. R. McGillis, and D. Perovich was provided by NSF ANT 09-44643. Given the nature of this data as laboratory based, we have opted not to submit to an oceanographic repository but all the data have been archived and are available by contacting Brice Loose (brice@gso.uri.edu). NR 44 TC 2 Z9 2 U1 3 U2 15 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-9275 EI 2169-9291 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD DEC PY 2015 VL 120 IS 12 BP 8177 EP 8194 DI 10.1002/2014JC010607 PG 18 WC Oceanography SC Oceanography GA DC3XO UT WOS:000369153200025 ER PT J AU Abbott, JH Chapple, CM Fitzgerald, GK Fritz, JM Childs, JD Harcombe, H Stout, K AF Abbott, J. Haxby Chapple, Catherine M. Fitzgerald, G. Kelley Fritz, Julie M. Childs, John D. Harcombe, Helen Stout, Kirsten TI The Incremental Effects of Manual Therapy or Booster Sessions in Addition to Exercise Therapy for Knee Osteoarthritis: A Randomized Clinical Trial SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE arthralgia; OA; physical therapy techniques; randomized controlled trial ID PHYSICAL-THERAPY; FUNCTIONAL SCALE; HOME EXERCISE; HIP; PHYSIOTHERAPY; PEOPLE; GUIDELINES; MANAGEMENT; CRITERIA; PAIN AB STUDY DESIGN: A factorial randomized controlled trial. OBJECTIVES: To investigate the addition of manual therapy to exercise therapy for the reduction of pain and increase of physical function in people with knee osteoarthritis (OA), and whether "booster sessions" compared to consecutive sessions may improve outcomes. BACKGROUND: The benefits of providing manual therapy in addition to exercise therapy, or of distributing treatment sessions over time using periodic booster sessions, in people with knee OA are not well established. METHODS: All participants had knee OA and were provided 12 sessions of multimodal exercise therapy supervised by a physical therapist. Participants were randomly allocated to 1 of 4 groups: exercise therapy in consecutive sessions, exercise therapy distributed over a year using booster sessions, exercise therapy plus manual therapy without booster sessions, and exercise therapy plus manual therapy with booster sessions. The primary outcome measure was the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC score; 0-240 scale) at 1-year follow-up. Secondary outcome measures were the numeric pain-rating scale and physical performance tests. RESULTS: Of 75 participants recruited, 66 (88%) were retained at 1-year follow-up. Factorial analysis of covariance of the main effects showed significant benefit from booster sessions (P =.009) and manual therapy (P =.023) over exercise therapy alone. Group analysis showed that exercise therapy with booster sessions (WOMAC score, -46.0 points; 95% confidence interval [CI]: -80.0, -12.0) and exercise therapy plus manual therapy (WOMAC score, -37.5 points; 95% CI: -69.7, -5.5) had superior effects compared with exercise therapy alone. The combined strategy of exercise therapy plus manual therapy with booster sessions was not superior to exercise therapy alone. CONCLUSION: Distributing 12 sessions of exercise therapy over a year in the form of booster sessions was more effective than providing 12 consecutive exercise therapy sessions. Providing manual therapy in addition to exercise therapy improved treatment effectiveness compared to providing 12 consecutive exercise therapy sessions alone. Trial registered with the Australian New Zealand Clinical Trials Registry (ACTRN12612000460808). C1 [Abbott, J. Haxby; Harcombe, Helen; Stout, Kirsten] Univ Otago, Dunedin Sch Med, Ctr Musculoskeletal Outcomes Res, Orthopaed Surg Sect,Dept Surg Sci, Dunedin, New Zealand. [Chapple, Catherine M.] Univ Otago, Sch Physiotherapy, Dunedin, New Zealand. [Fitzgerald, G. Kelley] Univ Pittsburgh, Pittsburgh, PA USA. [Fritz, Julie M.] Univ Utah, Salt Lake City, UT USA. [Childs, John D.] US Army Baylor Univ, Schertz, TX USA. [Harcombe, Helen] Univ Otago, Dept Prevent & Social Med, Dunedin, New Zealand. RP Abbott, JH (reprint author), Univ Otago, Dunedin Sch Med, Dept Surg Sci, Ctr Musculoskeletal Outcomes Res, POB 913, Dunedin, New Zealand. EM haxby.abbott@otago.ac.nz OI Abbott, J. Haxby/0000-0001-6468-7284; Chapple, Cathy/0000-0001-5141-8376 FU New Zealand Lottery Grants Board; New Zealand Society of Physiotherapists Scholarship Trust; Health Research Council of New Zealand; University of Otago Research Grant; Sir Charles Hercus Health Research Fellowship from the Health Research Council of New Zealand FX The study protocol was approved by the Lower South Regional Ethics Committee of the New Zealand Ministry of Health (LSR/10/11/055), and registered with the Australian New Zealand Clinical Trials Registry (ACTRN12612000460808). This research was supported in part by the New Zealand Lottery Grants Board, the New Zealand Society of Physiotherapists Scholarship Trust, the Health Research Council of New Zealand, and a University of Otago Research Grant. Dr Abbott was supported in part by a Sir Charles Hercus Health Research Fellowship from the Health Research Council of New Zealand. The funders have had no influence on the content of that work or the current article. The authors certify that they have no affiliations with or financial involvement in any organization or entity with a direct financial interest in the subject matter or materials discussed in the article. NR 33 TC 6 Z9 6 U1 4 U2 10 PU J O S P T PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 EI 1938-1344 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD DEC PY 2015 VL 45 IS 12 BP 975 EP 983 DI 10.2519/jospt.2015.6015 PG 9 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA DC7DA UT WOS:000369377800004 PM 26416334 ER PT J AU Kang, T Louden, JE Ricks, EP Jones, RL AF Kang, Tamara Louden, Jennifer Eno Ricks, Elijah P. Jones, Rachell L. TI Aggression, Substance Use Disorder, and Presence of a Prior Suicide Attempt Among Juvenile Offenders With Subclinical Depression SO LAW AND HUMAN BEHAVIOR LA English DT Article DE aggression; juvenile offenders; subclinical depression; substance abuse; suicide ID SELF-MEDICATION HYPOTHESIS; MENTAL-HEALTH COURT; PERSONALITY-DISORDERS; PSYCHIATRIC-DISORDERS; CRIMINAL RECIDIVISM; NATIONAL COHORT; DSM-V; RISK; ADOLESCENCE; DELINQUENCY AB Juvenile justice agencies often use the presence of a Diagnostic and Statistical Manual of Mental Disorders (DSM) diagnosis as a criterion for offenders' eligibility for mental health treatment. However, relying on diagnoses to sort offenders into discrete categories ignores subclinical disorders-impairment that falls below the threshold of DSM criteria. The current study used structured clinical interviews with 489 juvenile offenders to examine aggression, presence of a prior suicide attempt, and substance use disorders among juvenile offenders with subclinical depression compared with juvenile offenders with major depression or no mood disorder. Analyses demonstrated that juvenile offenders with subclinical depression reported significantly more aggression, abuse of substances, and the presence of a prior suicide attempt compared to juvenile offenders with no mood disorder, but did not differ significantly on aggression and substance abuse compared with juvenile offenders with major depression. These results have implications for correctional agencies' policies through which offenders are offered mental health treatment, and provide a first step in identifying early signs of problematic behavior before it worsens. Specifically, the results support the notion that depressive disorders should be viewed along a continuum when determining how to allocate services. C1 [Kang, Tamara; Louden, Jennifer Eno; Ricks, Elijah P.; Jones, Rachell L.] Univ Texas El Paso, Dept Psychol, 500 West Univ Ave, El Paso, TX 79902 USA. [Ricks, Elijah P.] Roosevelt Univ, Dept Psychol, Chicago, IL USA. [Jones, Rachell L.] US Army Res Inst Behav & Social Sci, Ft Leavenworth, KS USA. RP Kang, T (reprint author), Univ Texas El Paso, Dept Psychol, 500 West Univ Ave, El Paso, TX 79902 USA. EM tkang2@miners.utep.edu NR 65 TC 2 Z9 2 U1 2 U2 7 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0147-7307 EI 1573-661X J9 LAW HUMAN BEHAV JI Law Hum. Behav. PD DEC PY 2015 VL 39 IS 6 BP 593 EP 601 DI 10.1037/lhb0000145 PG 9 WC Law; Psychology, Social SC Government & Law; Psychology GA DC7NH UT WOS:000369406600006 PM 26168168 ER PT J AU De Julio, A Ferrari, C Levin, G AF De Julio, Adriana Ferrari, Chiara Levin, Geoffrey TI A Patient with Prolonged Psychosis after Electroconvulsive Therapy SO PSYCHIATRIC ANNALS LA English DT Editorial Material ID DEPRESSION; DELIRIUM C1 [De Julio, Adriana] US Army, Washington, DC USA. [De Julio, Adriana; Ferrari, Chiara] Advocate Lutheran Gen Hos, Dept Psychiat, Park Ridge, IL 60068 USA. [Levin, Geoffrey] Advocate Lutheran Gen Hos, Adult Psychiat, Park Ridge, IL USA. RP De Julio, A (reprint author), Advocate Lutheran Gen Hos, Dept Psychiat, Park Ridge, IL 60068 USA.; De Julio, A (reprint author), Advocate Lutheran Gen Hosp, 1775 Dempster St, Park Ridge, IL 60068 USA. EM adriana.dejulio@advocatehealth.com FU James R. & Helen D. Russell Institute for Research Innovation FX Manuscript review and editing was performed by Suela Sulo, PhD (James R. & Helen D. Russell Institute for Research & Innovation, Advocate Lutheran General Hospital). We thank the James R. & Helen D. Russell Institute for Research & Innovation for support with the manuscript of this article. NR 12 TC 0 Z9 0 U1 1 U2 2 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0048-5713 EI 1938-2456 J9 PSYCHIAT ANN JI Psychiatr. Ann. PD DEC PY 2015 VL 45 IS 12 BP 590 EP 592 DI 10.3928/00485713-20151030-02 PG 3 WC Psychiatry SC Psychiatry GA DC9EL UT WOS:000369523800002 ER PT J AU Tozier, W AF Tozier, William TI The Interservice Physician Assistant Program: The veterans' solution SO JAAPA-JOURNAL OF THE AMERICAN ACADEMY OF PHYSICIAN ASSISTANTS LA English DT Editorial Material C1 [Tozier, William] US Army, Washington, DC 20319 USA. [Tozier, William] Univ Washington, Interserv Phys Assistant Program, Seattle, WA 98195 USA. [Tozier, William] Univ Washington, MEDEX Northwest PA Program, Seattle, WA 98195 USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1547-1896 EI 0893-7400 J9 JAAPA-J AM ACAD PHYS JI JAAPA-J. Am. Acad. Physician Assist. PD DEC PY 2015 VL 28 IS 12 BP 14 EP 14 DI 10.1097/01.JAA.0000473371.09631.59 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA DC0HW UT WOS:000368898800002 PM 26556216 ER PT J AU Wildman, RA Gazonas, GA AF Wildman, Raymond A. Gazonas, George A. TI A DYNAMIC ELECTRO-THERMO-MECHANICAL MODEL OF DIELECTRIC BREAKDOWN IN SOLIDS USING PERIDYNAMICS SO JOURNAL OF MECHANICS OF MATERIALS AND STRUCTURES LA English DT Article; Proceedings Paper CT Peridynamic Theory symposium CY JUN, 2014 CL Michigan State Univ, East Lansing, MI HO Michigan State Univ DE dielectric breakdown; peridynamics; electromechanical; multiphysics ID ELASTICITY THEORY; POLYETHYLENE; PHOTOGRAPHY; LIQUIDS; FIELDS AB The electro-thermo-mechanical breakdown of dielectric solids is modeled using peridynamics to describe the brittle fracture of a material under high electric fields. A coupled electrostatic, elastodynamic, thermodynamic model is used wherein electrostatic forces are computed and applied to the mechanical model and temperature effects are included. Fracture is simulated using peridynamics, a reformulation of elasticity that incorporates material failure. Coupling occurs between the electrostatic and mechanical forces and also the electrical material properties: specifically, the Lorentz and Kelvin forces are used to couple the electrostatic fields to the stress fields, conductivity is treated as nonlinear and a function of temperature, and mechanical damage is used to alter the permittivity. Results demonstrate that the method is capable of reproducing branching breakdown patterns seen in experiments using a deterministic method. C1 [Wildman, Raymond A.; Gazonas, George A.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Wildman, RA (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM raymond.a.wildman.civ@mail.mil; george.a.gazonas.civ@mail.mil NR 41 TC 0 Z9 0 U1 7 U2 11 PU MATHEMATICAL SCIENCE PUBL PI BERKELEY PA UNIV CALIFORNIA, DEPT MATHEMATICS, BERKELEY, CA 94720-3840 USA SN 1559-3959 J9 J MECH MATER STRUCT JI J. Mech. Mater. Struct. PD DEC PY 2015 VL 10 IS 5 SI SI BP 613 EP 630 DI 10.2140/jomms.2015.10.613 PG 18 WC Materials Science, Multidisciplinary; Mechanics SC Materials Science; Mechanics GA DC0NL UT WOS:000368914200006 ER PT J AU Simper, N Deveaux, PG Burgess, PL AF Simper, Novae Deveaux, Peter G. Burgess, Pamela L. TI An Unusual Case of Lymphadenopathy Due to Traumatic Foreign-Body-Associated Granulomatous Lymphadenitis SO AMERICAN SURGEON LA English DT Article C1 [Simper, Novae] Indiana Univ Sch Med, Dept Pathol, Indianapolis, IN 46202 USA. [Deveaux, Peter G.] Univ Louisville, Dept Colorectal Surg, Louisville, KY 40292 USA. [Burgess, Pamela L.] Dwight D Eisenhower Army Med Ctr, Dept Gen Surg, Ft Gordon, GA 30905 USA. RP Burgess, PL (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Gen Surg, 300 E Hosp Rd, Ft Gordon, GA 30905 USA. EM burgesspl@gmail.com NR 4 TC 0 Z9 0 U1 0 U2 0 PU SOUTHEASTERN SURGICAL CONGRESS PI CUMMING PA 115 SAMARITAN DR, #200, CUMMING, GA 30040-2354 USA SN 0003-1348 EI 1555-9823 J9 AM SURGEON JI Am. Surg. PD DEC PY 2015 VL 81 IS 12 BP E422 EP E423 PG 2 WC Surgery SC Surgery GA DB4BR UT WOS:000368458200011 PM 26736150 ER PT J AU Allen, KC Sanchez, CJ Niece, KL Wenke, JC Akers, KS AF Allen, Kahtonna C. Sanchez, Carlos J., Jr. Niece, Krista L. Wenke, Joseph C. Akers, Kevin S. TI Voriconazole Enhances the Osteogenic Activity of Human Osteoblasts In Vitro through a Fluoride-Independent Mechanism SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID UNFOLDED PROTEIN RESPONSE; LUNG-TRANSPLANT RECIPIENT; SIGNALING PATHWAY; HETEROTOPIC OSSIFICATION; INDUCED PERIOSTITIS; TRAUMATIZED MUSCLE; FUNGAL-INFECTIONS; GENE-EXPRESSION; ER STRESS; BONE AB Periostitis, which is characterized by bony pain and diffuse periosteal ossification, has been increasingly reported with prolonged clinical use of voriconazole. While resolution of clinical symptoms following discontinuation of therapy suggests a causative role for voriconazole, the biological mechanisms contributing to voriconazole-induced periostitis are unknown. To elucidate potential mechanisms, we exposed human osteoblasts in vitro to voriconazole or fluconazole at 15 or 200 mu g/ml (reflecting systemic or local administration, respectively), under nonosteogenic or osteogenic conditions, for 1, 3, or 7 days and evaluated the effects on cell proliferation (reflected by total cellular DNA) and osteogenic differentiation (reflected by alkaline phosphatase activity, calcium accumulation, and expression of genes involved in osteogenic differentiation). Release of free fluoride, vascular endothelial growth factor (VEGF), and platelet-derived growth factor (PDGF) was also measured in cell supernatants of osteoblasts exposed to triazoles, with an ion-selective electrode (for free fluoride) and enzyme-linked immunosorbent assays (ELISAs) (for VEGF and PDGF). Voriconazole but not fluconazole significantly enhanced the proliferation and differentiation of osteoblasts. In contrast to clinical observations, no increases in free fluoride levels were detected following exposure to either voriconazole or fluconazole; however, significant increases in the expression of VEGF and PDGF by osteoblasts were observed following exposure to voriconazole. Our results demonstrate that voriconazole can induce osteoblast proliferation and enhance osteogenic activity in vitro. Importantly, and in contrast to the previously proposed mechanism of fluoride-stimulated osteogenesis, our findings suggest that voriconazole-induced periostitis may also occur through fluoride-independent mechanisms that enhance the expression of cytokines that can augment osteoblastic activity. C1 [Allen, Kahtonna C.; Akers, Kevin S.] JBSA Ft Sam Houston, San Antonio Mil Med Ctr, Dept Med, Infect Dis Serv, San Antonio, TX 78234 USA. [Sanchez, Carlos J., Jr.; Niece, Krista L.; Wenke, Joseph C.; Akers, Kevin S.] JBSA Ft Sam Houston, US Army Inst Surg Res, Extrem Trauma & Regenerat Med Task Area, San Antonio, TX USA. RP Akers, KS (reprint author), JBSA Ft Sam Houston, San Antonio Mil Med Ctr, Dept Med, Infect Dis Serv, San Antonio, TX 78234 USA. EM kevin.s.akers.mil@mail.mil FU Combat Casualty Research Program, U.S. Army Medical Research and Materiel Command; Oak Ridge Institute for Science and Education fellowship FX This work was supported by intramural funding from the Combat Casualty Research Program, U.S. Army Medical Research and Materiel Command, to J.C.W. C.J.S. was supported by an Oak Ridge Institute for Science and Education fellowship. NR 46 TC 3 Z9 3 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD DEC PY 2015 VL 59 IS 12 BP 7205 EP 7213 DI 10.1128/AAC.00872-15 PG 9 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA DB2KO UT WOS:000368337300006 PM 26324277 ER PT J AU Carmack, E Polyakov, I Padman, L Fer, I Hunke, E Hutchings, J Jackson, J Kelley, D Kwok, R Layton, C Melling, H Perovich, D Persson, O Ruddick, B Timmermans, ML Toole, J Ross, T Vavrus, S Winsor, P AF Carmack, E. Polyakov, I. Padman, L. Fer, I. Hunke, E. Hutchings, J. Jackson, J. Kelley, D. Kwok, R. Layton, C. Melling, H. Perovich, D. Persson, O. Ruddick, B. Timmermans, M. -L. Toole, J. Ross, T. Vavrus, S. Winsor, P. TI TOWARD QUANTIFYING THE INCREASING ROLE OF OCEANIC HEAT IN SEA ICE LOSS IN THE NEW ARCTIC SO BULLETIN OF THE AMERICAN METEOROLOGICAL SOCIETY LA English DT Article ID HORIZONTAL DENSITY STRUCTURE; ATLANTIC WATER; BOUNDARY CURRENT; FRAM STRAIT; INTERNAL WAVES; BEAUFORT SEA; YERMAK PLATEAU; PACIFIC WATER; SURFACE-LAYER; CANADA BASIN AB The loss of Arctic sea ice has emerged as a leading signal of global warming. This, together with acknowledged impacts on other components of the Earth system, has led to the term the new Arctic. Global coupled climate models predict that ice loss will continue through the twenty-first century, with implications for governance, economics, security, and global weather. A wide range in model projections reflects the complex, highly coupled interactions between the polar atmosphere, ocean, and cryosphere, including teleconnections to lower latitudes. This paper summarizes our present understanding of how heat reaches the ice base from the original sourcesinflows of Atlantic and Pacific Water, river discharge, and summer sensible heat and shortwave radiative fluxes at the ocean/ice surfaceand speculates on how such processes may change in the new Arctic. The complexity of the coupled Arctic system, and the logistic and technological challenges of working in the Arctic Ocean, require a coordinated interdisciplinary and international program that will not only improve understanding of this critical component of global climate but will also provide opportunities to develop human resources with the skills required to tackle related problems in complex climate systems. We propose a research strategy with components that include 1) improved mapping of the upper- and middepth Arctic Ocean, 2) enhanced quantification of important process, 3) expanded long-term monitoring at key heat-flux locations, and 4) development of numerical capabilities that focus on parameterization of heat-flux mechanisms and their interactions. C1 [Carmack, E.] Fisheries & Oceans Canada, Sidney, BC, Canada. [Carmack, E.] Univ Alaska Fairbanks, Coll Nat Sci & Math, Fairbanks, AK USA. [Polyakov, I.] Univ Alaska Fairbanks, Int Arct Res Ctr, Fairbanks, AK USA. [Polyakov, I.] Univ Alaska Fairbanks, Coll Nat Sci & Math, Fairbanks, AK USA. [Padman, L.] Earth & Space Res, Corvallis, OR USA. [Fer, I.] Univ Bergen, Inst Geophys, Bergen, Norway. [Fer, I.] Univ Bergen, Bjerknes Ctr Climate Res, Bergen, Norway. [Hunke, E.] Los Alamos Natl Lab, Los Alamos, NM USA. [Hutchings, J.] Oregon State Univ, Corvallis, OR 97331 USA. [Jackson, J.] Hakai Inst, Heriot Bay, BC, Canada. [Kelley, D.; Layton, C.; Ruddick, B.] Dalhousie Univ, Halifax, NS, Canada. [Kwok, R.] CALTECH, Jet Prop Lab, Pasadena, CA USA. [Melling, H.] Fisheries & Oceans Canada, Sidney, BC, Canada. [Perovich, D.] US Army, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Persson, O.] Univ Colorado, Cooperat Inst Res Environm Sci, Boulder, CO 80309 USA. [Timmermans, M. -L.] Yale Univ, New Haven, CT USA. [Toole, J.] Woods Hole Oceanog Inst, Woods Hole, MA 02543 USA. [Vavrus, S.] Univ Wisconsin, Ctr Climat Res, Madison, WI USA. [Winsor, P.] Univ Alaska Fairbanks, Inst Marine Sci, Fairbanks, AK USA. RP Polyakov, I (reprint author), UAF, IARC, POB 757335, Fairbanks, AK 99775 USA. EM igor@iarc.uaf.edu RI Kwok, Ron/A-9762-2008; OI Kwok, Ron/0000-0003-4051-5896; Jackson, Jennifer/0000-0002-2318-8814 FU IARC; College of Natural Science and Mathematics, University of Alaska Fairbanks FX The document reflects contributions and discussions from a Sydney Chapman Chair workshop entitled "An Untersteiner Workshop: On the Role and Consequences of Ocean Heat Flux in Sea Ice Melt," held 19-21 March 2013 at the International Arctic Research Center (IARC) at the University of Alaska Fairbanks. We deeply appreciate the logistics support offer by L. Hinzman, and staff of IARC, and financial support provided by IARC and by the College of Natural Science and Mathematics, University of Alaska Fairbanks. NR 219 TC 11 Z9 11 U1 12 U2 38 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 0003-0007 EI 1520-0477 J9 B AM METEOROL SOC JI Bull. Amer. Meteorol. Soc. PD DEC PY 2015 VL 96 IS 12 BP 2079 EP 2105 DI 10.1175/BAMS-D-13-00177.1 PG 27 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA DB4RP UT WOS:000368501100001 ER PT J AU Maldonado, JA Bruins, RB Yang, T Wright, A Dunne, CP Karwe, MV AF Maldonado, Jose Antonio Bruins, Rieks B. Yang, Tom Wright, Alan Dunne, C. Patrick Karwe, Mukund V. TI BROWNING AND ASCORBIC ACID DEGRADATION IN MEALS READY-TO-EAT PEAR RATIONS IN ACCELERATED SHELF LIFE SO JOURNAL OF FOOD PROCESSING AND PRESERVATION LA English DT Article ID CHELATE CATALYZED OXIDATION; ORANGE JUICE; VITAMIN-C; MOLECULAR-OXYGEN; CITRUS JUICE; METAL-ION; STORAGE; CONCENTRATE; KINETICS; DECOMPOSITION AB Pears in syrup in flexible pouches are part of the U.S. Army's Meals Ready-to-Eat rations, which are expected to have a shelf life of 3 years at 26.7C. However, browning during storage was reducing the shelf life. Pear pouches were subjected to complete headspace removal and rotation during retorting for extended shelf life of 45 days at 48.9C. The pears were tested for browning, ascorbic acid and headspace composition during storage. A combination of complete headspace removal and rotation of pouches during retorting increased the acceptability of pear by decreasing ascorbic acid degradation and browning. Aerobic and anaerobic ascorbic acid degradation reactions took place in the pears, with most of the aerobic degradation beginning during retorting. A lag period of several days between different stages of ascorbic acid degradation was detected. Finally, the ascorbic acid loss followed zero-order kinetics, with a reaction rate dependent on the initial concentration. C1 [Maldonado, Jose Antonio; Bruins, Rieks B.; Karwe, Mukund V.] Rutgers State Univ, Dept Food Sci, New Brunswick, NJ 08901 USA. [Yang, Tom; Wright, Alan; Dunne, C. Patrick] US Army, Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA. RP Karwe, MV (reprint author), Rutgers State Univ, Dept Food Sci, 65 Dudley Rd, New Brunswick, NJ 08901 USA. EM karwe@aesop.rutgers.edu FU U.S. Government Department of Defense; Defense Logistics Agency project CORANET [SP0103-02-D-0024, 0017, 2028]; New Jersey Agricultural Experimental Station FX The authors would like to acknowledge the U.S. Government Department of Defense and the Defense Logistics Agency project CORANET under contract # SP0103-02-D-0024; delivery order # 0017, Short Term Project (STP) # 2028 "Wet Pack Fruit Quality Improvement" for providing the funding for this project. Additionally, they would also like to acknowledge New Jersey Agricultural Experimental Station for providing additional funding. The authors would also like to acknowledge Truitt Brothers, Inc. (Salem, OR) for allowing us to use their facilities for pilot plant runs and SOPAKCO (Mullins, SC) for providing the samples of the MRE items currently used by the U.S. Army. NR 28 TC 0 Z9 0 U1 6 U2 14 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0145-8892 EI 1745-4549 J9 J FOOD PROCESS PRES JI J. Food Process Preserv. PD DEC PY 2015 VL 39 IS 6 BP 2035 EP 2042 DI 10.1111/jfpp.12446 PG 8 WC Food Science & Technology SC Food Science & Technology GA DA9JZ UT WOS:000368126300164 ER PT J AU Peluso, MJ Valcour, V Ananworanich, J Sithinamsuwan, P Chalermchai, T Fletcher, JLK Lerdlum, S Chomchey, N Slike, B Sailasuta, N Gisslen, M Zetterberg, H Spudich, S AF Peluso, Michael J. Valcour, Victor Ananworanich, Jintanat Sithinamsuwan, Pasiri Chalermchai, Thep Fletcher, James L. K. Lerdlum, Sukalya Chomchey, Nitiya Slike, Bonnie Sailasuta, Napapon Gisslen, Magnus Zetterberg, Henrik Spudich, Serena CA RV254 SEARCH 010 Team SEARCH 011 Study Team TI Absence of Cerebrospinal Fluid Signs of Neuronal Injury Before and After Immediate Antiretroviral Therapy in Acute HIV Infection SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE HIV/AIDS; antiretroviral therapy; neurofilament light chain; neurological injury; neuroinflammation; magnetic resonance spectroscopy ID NEUROFILAMENT PROTEIN NFL; NEUROCOGNITIVE DISORDERS; INDIVIDUALS; SEVERITY; COMPLEX; AIDS AB Background. It is unknown whether neuronal injury begins during acute human immunodeficiency virus (HIV) infection, and whether immediate initiation of combination antiretroviral therapy (cART) prevents neuronal injury. Methods. Cerebrospinal fluid (CSF) neurofilament light chain (NFL), ameasure of axonal injury, was assessed before and after cART initiation in individuals starting treatment during acute or chronic HIV infection. Nonparametric statistics examined relationships between NFL and disease progression, neuroinflammation, and cognitive performance. Results. Before treatment, subjects with acute infection had lower CSF NFL levels, with elevations for their age in 1 of 32 subjects with acute infection (3.1%) and 10 of 32 with chronic infection (31%) (P =.006). This persisted after cART initiation, with 1 of 25 acute (4%) and 4 of 9 chronic subjects (44%) showing elevated NFL levels (P =.01). In acute infection, pre-cART NFL levels were inversely correlated with proton magnetic resonance spectroscopic findings of N-acetylaspartate/creatine in frontal gray matter (r = -0.40; P =.03), frontal white matter (r = -0.46; P =.01), and parietal gray matter (r = -0.47; P=. 01); correlations persisted after treatment in the frontal white matter (r = -0.51; P =.02) and parietal gray matter (r = -0.46; P =.04). Conclusions. CSF NFL levels are not elevated in untreated acute HIV infection or after 6 months of immediately initiated cART but are abnormal in chronic HIV infection before and after treatment. In acute HIV infection, CSF NFL levels are inversely associated with neuroimaging markers of neuronal health. C1 [Peluso, Michael J.] Brigham & Womens Hosp, Dept Med, Boston, MA USA. [Valcour, Victor] Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA. [Ananworanich, Jintanat] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Ananworanich, Jintanat] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Sailasuta, Napapon] Huntington Med Res Inst, Pasadena, CA USA. [Spudich, Serena] Yale Univ, Sch Med, Dept Neurol, New Haven, CT 06510 USA. [Ananworanich, Jintanat; Chalermchai, Thep; Fletcher, James L. K.; Chomchey, Nitiya] Thai Red Cross AIDS Res Ctr, SEARCH, Bangkok, Thailand. [Sithinamsuwan, Pasiri] Phramongkutklao Hosp, Dept Internal Med, Div Neurol, Bangkok, Thailand. [Lerdlum, Sukalya] Chulalongkorn Univ, Fac Med, Bangkok 10330, Thailand. [Gisslen, Magnus] Univ Gothenburg, Sahlgrenska Acad, Dept Infect Dis, Inst Biomed, Molndal, Sweden. [Zetterberg, Henrik] Univ Gothenburg, Sahlgrenska Acad, Dept Psychiat & Neurochem, Inst Neurosci & Physiol, Molndal, Sweden. [Zetterberg, Henrik] UCL, Inst Neurol, London, England. RP Spudich, S (reprint author), Yale Univ, Dept Neurol, POB 208018, New Haven, CT 06520 USA. EM serena.spudich@yale.edu FU National Institute of Mental Health, National Institutes of Health [R01MH095613, R01NS061696, R21MH086341]; Sahlgrenska Academy at the University of Gothenburg [ALFGBG-11067]; Swedish Research Council [K2011 58P 20931 01]; US Military HIV Research Program FX This work was supported by the National Institute of Mental Health, National Institutes of Health (grants R01MH095613, R01NS061696, and R21MH086341), The Sahlgrenska Academy at the University of Gothenburg (grant ALFGBG-11067), the Swedish Research Council (grant K2011 58P 20931 01), and the US Military HIV Research Program. Antiretrovirals were generously provided by the Thai Government Pharmaceutical Company, Gilead, Merck, and ViiV Healthcare. NR 26 TC 6 Z9 6 U1 1 U2 4 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD DEC 1 PY 2015 VL 212 IS 11 BP 1759 EP 1767 DI 10.1093/infdis/jiv296 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA DB7BN UT WOS:000368669500011 PM 25995196 ER PT J AU Nagaraja, S Reifman, J Mitrophanov, AY AF Nagaraja, Sridevi Reifman, Jaques Mitrophanov, Alexander Y. TI Computational Identification of Mechanistic Factors That Determine the Timing and Intensity of the Inflammatory Response SO PLOS COMPUTATIONAL BIOLOGY LA English DT Article ID TRANSLATIONAL SYSTEMS BIOLOGY; NECROSIS-FACTOR-ALPHA; SENSITIVITY-ANALYSIS; MATHEMATICAL-MODEL; RHEUMATOID-ARTHRITIS; RESOLUTION; MACROPHAGES; INJURY; MICE; TUBERCULOSIS AB Timely resolution of inflammation is critical for the restoration of homeostasis in injured or infected tissue. Chronic inflammation is often characterized by a persistent increase in the concentrations of inflammatory cells and molecular mediators, whose distinct amount and timing characteristics offer an opportunity to identify effective therapeutic regulatory targets. Here, we used our recently developed computational model of local inflammation to identify potential targets for molecular interventions and to investigate the effects of individual and combined inhibition of such targets. This was accomplished via the development and application of computational strategies involving the simulation and analysis of thousands of inflammatory scenarios. We found that modulation of macrophage influx and efflux is an effective potential strategy to regulate the amount of inflammatory cells and molecular mediators in both normal and chronic inflammatory scenarios. We identified three molecular mediators - tumor necrosis factor-alpha (TNF-alpha), transforming growth factor-beta (TGF-beta), and the chemokine CXCL8 - as potential molecular targets whose individual or combined inhibition may robustly regulate both the amount and timing properties of the kinetic trajectories for neutrophils and macrophages in chronic inflammation. Modulation of macrophage flux, as well as of the abundance of TNF-alpha, TGF-beta, and CXCL8, may improve the resolution of chronic inflammation. C1 [Nagaraja, Sridevi; Reifman, Jaques; Mitrophanov, Alexander Y.] US Army, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Dept Def Biotechnol,High Performance Comp Softwar, Ft Detrick, MD USA. RP Nagaraja, S (reprint author), US Army, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Dept Def Biotechnol,High Performance Comp Softwar, Ft Detrick, MD USA. EM jaques.reifman.civ@mail.mil FU Clinical and Rehabilitative Medicine Research Program of the U.S. Army Medical Research and Materiel Command, Fort Detrick, MD FX The authors were supported by the Clinical and Rehabilitative Medicine Research Program of the U.S. Army Medical Research and Materiel Command, Fort Detrick, MD (http://mrmc.amedd.army.mil/). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 76 TC 2 Z9 2 U1 0 U2 0 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1553-734X EI 1553-7358 J9 PLOS COMPUT BIOL JI PLoS Comput. Biol. PD DEC PY 2015 VL 11 IS 12 AR e1004460 DI 10.1371/journal.pcbi.1004460 PG 26 WC Biochemical Research Methods; Mathematical & Computational Biology SC Biochemistry & Molecular Biology; Mathematical & Computational Biology GA DB4ZJ UT WOS:000368521900001 PM 26633296 ER PT J AU Bennett, KL Linton, YM Shija, F Kaddumukasa, M Djouaka, R Misinzo, G Lutwama, J Huang, YM Mitchell, LB Richards, M Tossou, E Walton, C AF Bennett, Kelly Louise Linton, Yvonne-Marie Shija, Fortunate Kaddumukasa, Martha Djouaka, Rousseau Misinzo, Gerald Lutwama, Julius Huang, Yiau-Min Mitchell, Luke B. Richards, Miriam Tossou, Eric Walton, Catherine TI Molecular Differentiation of the African Yellow Fever Vector Aedes bromeliae (Diptera: Culicidae) from Its Sympatric Nonvector Sister Species, Aedes lilii SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID EAST-AFRICA; SEQUENCE VARIATION; CHIKUNGUNYA VIRUS; DNA BARCODES; IDENTIFICATION; OUTBREAK; MOSQUITOS; REGION; EPIDEMIC; DISEASE AB Introduction Yellow fever continues to be a problem in sub-Saharan Africa with repeated epidemics occurring. The mosquito Aedes bromeliae is a major vector of yellow fever, but it cannot be readily differentiated from its non-vector zoophilic sister species Ae. lilii using morphological characters. Genetic differences have been reported between anthropophilic Ae. bromeliae and zoophilic Ae. lilii and between forest and domestic populations. However, due to the application of different molecular markers and non-overlapping populations employed in previous studies, interpretation of species delimitation is unclear. Methodology/Principle Findings DNA sequences were generated from specimens of Ae. simpsoni s. l. from the Republic of Benin, Tanzania and Uganda for two nuclear genes apolipophorin 2 (apoLp2) and cytochrome p450 (CYPJ92), the ribosomal internal transcribed spacer region (ITS) and the mitochondrial cytochrome c oxidase (COI) barcoding region. Nuclear genes apoLp2 and CYPJ92 were unable to differentiate between species Ae. bromeliae and Ae. lilii due to ancestral lineage sorting, while ITS sequence data provided clear topological separation on a phylogeny. The standard COI barcoding region was shown to be subject to species introgression and unable to clearly distinguish the two taxa. Here we present a reliable direct PCR-based method for differentiation of the vector species Ae. bromeliae from its isomorphic, sympatric and non-biomedically important sister taxon, Ae. lilii, based on the ITS region. Using molecular species verification, we describe novel immature habitats for Ae. lilii and report both sympatric and allopatric populations. Whereas only Ae. lilii is found in the Republic of Benin and only Ae. bromeliae in Tanzania, both species are sympatric in Uganda. Conclusions/Significance Our accurate identification method will allow informed distribution and detailed ecological studies that will facilitate assessment of arboviral disease risk and development of future targeted vector control. C1 [Bennett, Kelly Louise; Shija, Fortunate; Walton, Catherine] Univ Manchester, Computat Evolutionary Biol Grp, Fac Life Sci, Manchester, Lancs, England. [Linton, Yvonne-Marie; Huang, Yiau-Min; Mitchell, Luke B.] Smithsonian Inst Museum Support Ctr, Walter Reed Biosystemat Unit, Suitland, MD USA. [Linton, Yvonne-Marie] Walter Reed Army Inst Res, Silver Spring, MD USA. [Linton, Yvonne-Marie] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Linton, Yvonne-Marie; Huang, Yiau-Min; Mitchell, Luke B.] Natl Museum Nat Hist, Dept Entomol, Smithsonian Inst, Washington, DC 20560 USA. [Shija, Fortunate; Misinzo, Gerald; Richards, Miriam] Sokoine Univ Agr, Dept Vet Microbiol & Parasitol, Morogoro, Tanzania. [Kaddumukasa, Martha; Lutwama, Julius] Uganda Virus Res Inst, Dept Arbovirol Emerging & Re Eemerging Infect, Entebbe, Uganda. [Djouaka, Rousseau; Tossou, Eric] Agroecohlth Platform West & Cent Africa, Int Inst Trop Agr, Porto Novo, Benin. RP Bennett, KL (reprint author), Univ Manchester, Computat Evolutionary Biol Grp, Fac Life Sci, Manchester, Lancs, England. EM Catherine.walton@manchester.ac.uk FU Royal Society; Leverhulme Trust [(AA110092]; Natural Environment Research Council [NE/H525170/1, NE/1528134/1, NE/J500057/1]; National Research Council (NRC) FX This work was supported by an Africa Award from the Royal Society and Leverhulme Trust (AA110092) and a PhD studentship to KLB funded by the Natural Environment Research Council [NE/H525170/1, NE/1528134/1, NE/J500057/1]. This manuscript was prepared whilst YML held a National Research Council (NRC) Research Associateship Award at the Walter Reed Army Institute of Research. The material to be published reflects the views of the authors and should not be construed to represent those of the Department of the Army or the Department of Defense. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 72 TC 1 Z9 1 U1 1 U2 11 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD DEC PY 2015 VL 9 IS 12 AR e0004250 DI 10.1371/journal.pntd.0004250 PG 19 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA DB2NG UT WOS:000368345100027 PM 26641858 ER PT J AU Clapham, H Cummings, DAT Nisalak, A Kalayanarooj, S Thaisomboonsuk, B Klungthong, C Fernandez, S Srikiatkhachorn, A Macareo, LR Lessler, J Reiser, J Yoon, IK AF Clapham, Hannah Cummings, Derek A. T. Nisalak, Ananda Kalayanarooj, Siripen Thaisomboonsuk, Butsaya Klungthong, Chonticha Fernandez, Stefan Srikiatkhachorn, Anon Macareo, Louis R. Lessler, Justin Reiser, Julia Yoon, In-Kyu TI Epidemiology of Infant Dengue Cases Illuminates Serotype-Specificity in the Interaction between Immunity and Disease, and Changes in Transmission Dynamics SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID HEMORRHAGIC-FEVER; ANTIBODY-RESPONSE; VIRUS; PATHOGENESIS; INFECTIONS; THAILAND; PROTECTION; SEVERITY; ANTIGEN; VACCINE AB Background Infants born to dengue immune mothers acquire maternal antibodies to dengue. These antibodies, though initially protective, decline during the first year of life to levels thought to be disease enhancing, before reaching undetectable levels. Infants have long been studied to understand the interaction between infection and disease on an individual level. Methods/Findings Considering infants (cases < 1 year old) as a unique group, we analyzed serotype specific dengue case data from patients admitted to a pediatric hospital in Bangkok, Thailand. We show differences in the propensity of serotypes to cause disease in individuals with dengue antibodies (infants and post-primary cases) and in individuals without dengue antibodies (primary cases). The mean age of infant cases differed among serotypes, consistent with previously observed differential waning of maternal antibody titers by serotype. We show that trends over time in epidemiology of infant cases are consistent with those observed in the whole population, and therefore with trends in the force of infection. Conclusions/Significance Infants with dengue are informative about the interaction between antibody and the dengue serotypes, confirming that in this population DENV-2 and DENV-4 almost exclusively cause disease in the presence of dengue antibody despite infections occurring in others. We also observe differences between the serotypes in the mean age in infant cases, informative about the interaction between waning immunity and disease for the different serotypes in infants. In addition, we show that the mean age of infant cases over time is informative about transmission in the whole population. Therefore, ongoing surveillance for dengue in infants could provide useful insights into dengue epidemiology, particularly after the introduction of a dengue vaccine targeting adults and older children. C1 [Clapham, Hannah; Cummings, Derek A. T.; Reiser, Julia] Johns Hopkins Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21218 USA. [Cummings, Derek A. T.] Univ Florida, Dept Biol, Gainesville, FL USA. [Nisalak, Ananda; Thaisomboonsuk, Butsaya; Klungthong, Chonticha; Fernandez, Stefan; Macareo, Louis R.; Reiser, Julia] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Kalayanarooj, Siripen] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand. [Srikiatkhachorn, Anon] Univ Massachusetts, Sch Med, Dept Med, Div Infect Dis & Immunol, Worcester, MA USA. [Yoon, In-Kyu] Int Vaccine Inst, Dengue Vaccine Initiat, Seoul, South Korea. RP Clapham, H (reprint author), Johns Hopkins Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21218 USA. EM hclapha1@jhu.edu OI Lessler, Justin/0000-0002-9741-8109 FU National Institute of General Medical Sciences of the National Institutes of Health [U54 GM088491]; National Institutes of Health [5R01AI102939-03]; National Institute of Allergy and Infectious Diseases [5P01 AI034533-22]; [R01Al114703] FX The views expressed in this article are those of the authors and do not represent the official policy or position of the US Department of the Army, Department of Defense, or US Government. DATC received funding from the National Institute of General Medical Sciences of the National Institutes of Health under Award Number U54 GM088491 and received funding from grant R01Al114703. HC, JL and DATC received funding from the National Institutes of Health under Award Number 5R01AI102939-03. AS received funding from the National Institute of Allergy and Infectious Diseases under Award Number 5P01 AI034533-22. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 30 TC 0 Z9 0 U1 0 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD DEC PY 2015 VL 9 IS 12 AR e0004262 DI 10.1371/journal.pntd.0004262 PG 10 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA DB2NG UT WOS:000368345100037 PM 26658730 ER PT J AU Kelly, DJ Foley, DH Richards, AL AF Kelly, Daryl J. Foley, Desmond H. Richards, Allen L. TI A Spatiotemporal Database to Track Human Scrub Typhus Using the VectorMap Application SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Review ID POLYMERASE-CHAIN-REACTION; WEIL-FELIX REACTION; ORIENTIA-TSUTSUGAMUSHI; INDIRECT IMMUNOFLUORESCENCE; RICKETTSIA-TSUTSUGAMUSHI; MURINE TYPHUS; DIAGNOSIS; THAILAND; DISEASE; DIVERSITY AB Scrub typhus is a potentially fatal mite-borne febrile illness, primarily of the Asia-Pacific Rim. With an endemic area greater than 13 million km2 and millions of people at risk, scrub typhus remains an underreported, often misdiagnosed febrile illness. A comprehensive, updatable map of the true distribution of cases has been lacking, and therefore the true risk of disease within the very large endemic area remains unknown. The purpose of this study was to establish a database and map to track human scrub typhus. An online search using PubMed and the United States Armed Forces Pest Management Board Literature Retrieval System was performed to identify articles describing human scrub typhus cases both within and outside the traditionally accepted endemic regions. Using World Health Organization guidelines, stringent criteria were used to establish diagnoses for inclusion in the database. The preliminary screening of 181 scrub typhus publications yielded 145 publications that met the case criterion, 267 case records, and 13 serosurvey records that could be georeferenced, describing 13,739 probable or confirmed human cases in 28 countries. A map service has been established within VectorMap (www.vectormap.org) to explore the role that relative location of vectors, hosts, and the pathogen play in the transmission of mite-borne scrub typhus. The online display of scrub typhus cases in VectorMap illustrates their presence and provides an up-to-date geographic distribution of proven scrub typhus cases. C1 [Kelly, Daryl J.; Richards, Allen L.] Naval Med Res Ctr, Viral & Rickettsial Dis Dept, Silver Spring, MD 20910 USA. [Kelly, Daryl J.] Ohio State Univ, Dept Evolut Ecol & Organismal Biol, Columbus, OH 43210 USA. [Foley, Desmond H.] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD USA. [Richards, Allen L.] Uniformed Serv Univ Hlth Sci, Prevent Med & Biometr Dept, Bethesda, MD 20814 USA. RP Kelly, DJ (reprint author), Naval Med Res Ctr, Viral & Rickettsial Dis Dept, Silver Spring, MD 20910 USA. EM kelly.350@osu.edu OI Foley, Desmond/0000-0001-7525-4601 FU Armed Forces Health Surveillance Center, Global Emerging Infections Surveillance and Response Systems, Silver Spring, MD; [P0181_14_WR] FX This study was financially supported by the Armed Forces Health Surveillance Center, Global Emerging Infections Surveillance and Response Systems, Silver Spring, MD (https://www.afhsc.mil/Home/Divisions/GEIS), under a Memorandum of Understanding between the Walter Reed Army Institute of Research and the Smithsonian Institution, with institutional support provided by both organizations. Grant to DHF: grant # P0181_14_WR. ALR is an employee of the US Government and his work was prepared as part of his official duties. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 43 TC 2 Z9 2 U1 2 U2 6 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD DEC PY 2015 VL 9 IS 12 AR e0004161 DI 10.1371/journal.pntd.0004161 PG 13 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA DB2NG UT WOS:000368345100007 PM 26678263 ER PT J AU Cochet, AE Cunningham, JR Butler, SL AF Cochet, Allyson E. Cunningham, John Ryan Butler, Samantha L. TI Pseudomelanosis duodeni and Strongyloides stercoralis SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Editorial Material C1 [Cochet, Allyson E.; Cunningham, John Ryan; Butler, Samantha L.] Brooke Army Med Ctr, San Antonio, TX 78234 USA. RP Cochet, AE (reprint author), Brooke Army Med Ctr, San Antonio, TX 78234 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD DEC PY 2015 VL 110 IS 12 BP 1651 EP 1651 DI 10.1038/ajg.2015.113 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA DB1NJ UT WOS:000368274700005 PM 26673486 ER PT J AU Tannenbaum, LV Flaws, JA AF Tannenbaum, Lawrence V. Flaws, Jodi A. TI Exposure Duration-Dependent Ovarian Recovery in Methoxychlor-Treated Mice SO BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY LA English DT Article DE methoxychlor; antral follicle; atresia; ovary; recovery ID ATRESIA; MOUSE; RISK AB The pesticide methoxychlor (MXC) is known to target ovarian antral follicles in the mouse. In previous in vivo studies, fertility immediately after dosing. Thus, we hypothesized that perhaps not enough time had elapsed between the onset ofMXC-induced atresia and actual follicle loss to result in reduced fertility. The current study was undertaken to determine whether MXC treatment for 20 days results in reduced antral follicle numbers and fertility at 30 and 60 days after dosing. To test this hypothesis, adult CD-1 female mice were dosed with vehicle control or MXC (64 mg/kg/day) for 20 days. At 30 and 60 days postdosing, the mice were either subjected to fertility tests or their ovaries were collected and subjected to histological evaluation of follicle numbers and atresia. The results indicate that at 30 days after the completion of dosing, MXC significantly increased atresia and reduced primordial and total follicle numbers, but did not affect fertility compared to controls. At 60 days after completion of dosing, MXC did not significantly affect fertility, follicle numbers, or atresia compared to controls. Collectively, these data indicate that the ovary may be able to recover from MXC treatment for 20 days. (C) 2015 Wiley Periodicals, Inc. C1 [Tannenbaum, Lawrence V.] US Army, Publ Hlth Ctr, Aberdeen Proving Ground, MD USA. [Flaws, Jodi A.] Univ Illinois, Dept Comparat Biosci, Urbana, IL 61802 USA. RP Flaws, JA (reprint author), Univ Illinois, Dept Comparat Biosci, 2001 S Lincoln Ave, Urbana, IL 61802 USA. EM jflaws@illinois.edu FU Eunice Kennedy Shriver NICHD/NIH (NCTRI) [P50-HD28934] FX The authors thank Liying Gao and Emily Brehm for the assistance with the ovarian histological evaluations and they thank Sherri Hutchens and Jeffrey Leach for the manuscript review. The University of Virginia Center for Research in Reproduction Ligand Assay and Analysis Core is supported by the Eunice Kennedy Shriver NICHD/NIH (NCTRI) Grant P50-HD28934. NR 21 TC 0 Z9 0 U1 1 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1542-9733 EI 1542-9741 J9 BIRTH DEFECTS RES B JI Birth Defects Res. Part B-Dev. Reprod. Toxicol. PD DEC PY 2015 VL 104 IS 6 BP 238 EP 243 DI 10.1002/bdrb.21164 PG 6 WC Oncology; Genetics & Heredity; Toxicology SC Oncology; Genetics & Heredity; Toxicology GA DB0FD UT WOS:000368183100002 PM 26551443 ER PT J AU Kilianski, A Murch, RS AF Kilianski, Andy Murch, Randall S. TI When gain-of-function research is not "gain-of-function" research SO EMBO REPORTS LA English DT Editorial Material ID VIRUS; TRANSMISSION; FERRETS C1 [Kilianski, Andy] US Army Edgewood Chem Biol Ctr, Biodef Branch, BioSci Div, Aberdeen Proving Ground, MD 21010 USA. [Murch, Randall S.] Off Vice President, Arlington, VA USA. [Murch, Randall S.] Sch Publ & Int Affairs, Arlington, VA USA. [Murch, Randall S.] Virginia Tech Univ, Dept Plant Pathol Physiol & Weed Sci, Arlington, VA USA. RP Kilianski, A (reprint author), US Army Edgewood Chem Biol Ctr, Biodef Branch, BioSci Div, Aberdeen Proving Ground, MD 21010 USA. EM andrew.kilianski.ctr@mail.mil NR 10 TC 1 Z9 1 U1 0 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1469-221X EI 1469-3178 J9 EMBO REP JI EMBO Rep. PD DEC PY 2015 VL 16 IS 12 BP 1586 EP 1587 PG 2 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA DB0ZH UT WOS:000368237100003 PM 26538418 ER PT J AU Whitehouse, CA Chase, K Embers, ME Kulesh, DA Ladner, JT Palacios, GF Minogue, TD AF Whitehouse, Chris A. Chase, Kitty Embers, Monica E. Kulesh, David A. Ladner, Jason T. Palacios, Gustavo F. Minogue, Timothy D. TI Development of real-time PCR assays for the detection of Moraxella macacae associated with bloody nose syndrome in rhesus (Macaca mulatta) and cynomolgus (Macaca fascicularis) macaques SO JOURNAL OF MEDICAL PRIMATOLOGY LA English DT Article DE epistaxis; molecular diagnostics; non-human primates; veterinary microbiology ID NONHUMAN-PRIMATES; CATARRHALIS; EPISTAXIS; GENERA; FLORA AB Background Moraxella macacae is a recently described bacterial pathogen that causes epistaxis or so-called bloody nose syndrome in captive macaques. The aim of this study was to develop specific molecular diagnostic assays for M. macacae and to determine their performance characteristics. Methods We developed six real-time PCR assays on the Roche LightCycler. The accuracy, precision, selectivity, and limit of detection (LOD) were determined for each assay, in addition to further validation by testing nasal swabs from macaques presenting with epistaxis at the Tulane National Primate Research Center. Results All assays exhibited 100% specificity and were highly sensitive with an LOD of 10 fg for chromosomal assays and 1 fg for the plasmid assay. Testing of nasal swabs from 10 symptomatic macaques confirmed the presence of M. macacae in these animals. Conclusions We developed several accurate, sensitive, and species-specific real-time PCR assays for the detection of M. macacae in captive macaques. C1 [Whitehouse, Chris A.] US Army, Med Res Inst Infect Dis, Mol & Translat Sci Div, Ft Detrick, MD 21702 USA. [Chase, Kitty; Kulesh, David A.; Minogue, Timothy D.] US Army, Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. [Embers, Monica E.] Tulane Univ Hlth Sci, Tulane Natl Primate Res Ctr, Div Bacteriol & Parasitol, Covington, LA USA. [Ladner, Jason T.; Palacios, Gustavo F.] US Army, Med Res Inst Infect Dis, Ctr Genome Sci, Ft Detrick, MD 21702 USA. RP Minogue, TD (reprint author), US Army, Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. EM timothy.d.minogue.civ@mail.mil RI Palacios, Gustavo/I-7773-2015 OI Palacios, Gustavo/0000-0001-5062-1938 FU Defense Threat Reduction Agency [1881290] FX We thank Gail Plauche at the TNPRC for excellent clinical microbiology laboratory support and Lorraine Farinick for figure preparation. The research described in this report was made possible by financial support provided by the Defense Threat Reduction Agency Project No. 1881290. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army. NR 16 TC 0 Z9 0 U1 1 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0047-2565 EI 1600-0684 J9 J MED PRIMATOL JI J. Med. Primatol. PD DEC PY 2015 VL 44 IS 6 BP 364 EP 372 DI 10.1111/jmp.12196 PG 9 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA DB1ID UT WOS:000368260900003 PM 26365904 ER PT J AU Kocifaj, M Klacka, J Kundracik, F Videen, G AF Kocifaj, Miroslav Klacka, Jozef Kundracik, Frantisek Videen, Gorden TI Charge-induced electromagnetic resonances in nanoparticles SO ANNALEN DER PHYSIK LA English DT Article ID DUST PARTICLES; SCATTERING; WAVES; SPHERE AB Electromagnetic theories have reproduced the scattering properties of differently shaped particles and successfully been used to characterize numerous systems. However, certain anomalous features remain unexplained that include enhanced extinction when particles are much smaller than the wavelength. Here we explain these features exploiting recent research in electromagnetic scattering theories that suggests incorporating the effect of particle charge results in new physical outcomes that deviate appreciably from what is predicted by electromagnetic interaction from uncharged systems. For electrically charged particles, the resonant excitation of surface modes is governed by excess charges deposited on the particle surface. Charge effects become large when particles are small compared to the incident wavelength, and we show that the electrostatic approximation is not valid for modelling the electromagnetic interaction from such particles. Charge-induced resonances appear in such systems that can reproduce previously unexplained phenomena, for instance, amplified microwave attenuation observed in sandstorms. C1 [Kocifaj, Miroslav] Slovak Acad Sci, ICA, Bratislava 84503, Slovakia. [Kocifaj, Miroslav; Klacka, Jozef; Kundracik, Frantisek] Comenius Univ, Fac Math Phys & Informat, Bratislava 84248, Slovakia. [Videen, Gorden] US Army Res Lab, AMSRD ARL CI ES, Adelphi, MD 20783 USA. RP Kocifaj, M (reprint author), Slovak Acad Sci, ICA, Dubravska Rd 9, Bratislava 84503, Slovakia. EM kocifaj@savba.sk FU US Army International Technology Center (RD) [W911NF-14-1-0601, 1695-PH-01]; Slovak National Grant Agency VEGA [2/0002/12] FX This work was supported by the US Army International Technology Center under the contract No: W911NF-14-1-0601 (R&D 1695-PH-01). Computational work was supported by the Slovak National Grant Agency VEGA (grant No. 2/0002/12). The authors of near field codes for spheres, Peter W. Barber and Steven Hill, are gratefully acknowledged. NR 25 TC 5 Z9 5 U1 2 U2 8 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 0003-3804 EI 1521-3889 J9 ANN PHYS-BERLIN JI Ann. Phys.-Berlin PD DEC PY 2015 VL 527 IS 11-12 BP 765 EP 769 DI 10.1002/andp.201500202 PG 5 WC Physics, Multidisciplinary SC Physics GA DA3CH UT WOS:000367673000002 ER PT J AU Kott, A Alberts, DS Wang, C AF Kott, Alexander Alberts, David S. Wang, Cliff TI Will Cybersecurity Dictate the Outcome of Future Wars? SO COMPUTER LA English DT Article C1 [Kott, Alexander] US Army Res Lab, Network Sci Div, Adelphi, MD 20783 USA. [Alberts, David S.] Inst Def Anal, New Delhi, India. [Wang, Cliff] US Army Res Off, Div Comp Sci, West Point, PA USA. RP Kott, A (reprint author), US Army Res Lab, Network Sci Div, Adelphi, MD 20783 USA. EM alexander.kott1.civ@mail.mil; dalberts@ida.org; cliff.x.wang.civ@mail.mil NR 9 TC 1 Z9 1 U1 0 U2 3 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 0018-9162 EI 1558-0814 J9 COMPUTER JI Computer PD DEC PY 2015 VL 48 IS 12 BP 98 EP 101 PG 4 WC Computer Science, Hardware & Architecture; Computer Science, Software Engineering SC Computer Science GA DA3IC UT WOS:000367689400014 ER PT J AU Wilkens, JL Katzenmeyer, AW Hahn, NM Hoover, JJ Suedel, BC AF Wilkens, J. L. Katzenmeyer, A. W. Hahn, N. M. Hoover, J. J. Suedel, B. C. TI Laboratory test of suspended sediment effects on short-term survival and swimming performance of juvenile Atlantic sturgeon (Acipenser oxyrinchus oxyrinchus, Mitchill, 1815) SO JOURNAL OF APPLIED ICHTHYOLOGY LA English DT Article ID SOUTHERN APPALACHIAN MINNOWS; SALMON ONCORHYNCHUS-KISUTCH; SHOVELNOSE STURGEON; SCAPHIRHYNCHUS-ALBUS; PALLID STURGEON; PHYSIOLOGICAL-RESPONSES; LAKE STURGEON; FRESH-WATER; FISH; BEHAVIOR AB Tested was the hypothesis that juvenile Atlantic sturgeon (Acipenser oxyrinchus oxyrinchus) would exhibit no response in short-term survival or swimming performance when exposed to varying concentrations of suspended sediment simulating dredge plumes in waterways where this species may be impacted by dredging operations. Sediment collected from Savannah Harbor, South Carolina, USA was used to simulate a worst-case scenario. Juvenile sturgeon were contained for a 3-day period in flow-through aquaria, with limited opportunity for movement, in sediment of varying concentrations (100, 250 and 500 mg L-1 total suspended solids [TSS]) mimicking prolonged exposure to suspended sediment plumes near an operating dredge. Of the 90 fish exposed, 86 (96%) survived the test. Of the four fish that died, one was exposed to 250 TSS and three to 500 TSS. Swimming performance results indicated that nearly all fish were positively rheotactic. Critical swim speeds (U-crits) were moderate, whether measured as absolute values (21-31 cm s(-1)) or as relative values (1.4-2.1 body lengths s(-1)), with no significant differences among treatments (F < 0.83, P >= 0.4874). Behavior was dominated by contact-based locomotion and station-holding. Absence of substantial or significant immediate effects on survival and swimming performance suggest that impacts of sediment plumes in nature, where fish have freedom of movement and the power to escape rapidly, are minimal. C1 [Wilkens, J. L.; Katzenmeyer, A. W.; Hahn, N. M.; Hoover, J. J.; Suedel, B. C.] US Army, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Suedel, BC (reprint author), US Army, Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM burton.suedel@usace.army.mil FU Dredging Operations and Environmental Research Program FX Our thanks to Kent Ware, Bears Bluff National Fish Hatchery, Wadmalaw Island, South Carolina, USA for supplying the fish used in this study; Cynthia Williams, U.S. Fish and Wildlife Service, for assistance in facilitating the permitting process (Permit No. 17367); and Dennis Riecke and Charles Silkwood, Mississippi Department of Wildlife Fisheries and Parks, for the loan of the fish hauler. Sturgeon were held under the ERDC Environmental Laboratory's Institutional Animal Care and Use Protocol No. EL-5036-2012-1, and the experiment was conducted under Protocol No. EL-6008-2013-1. We also thank Jack Killgore, USACE ERDC, for his helpful insight and for reviewing an earlier version of the paper. This research was funded by the Dredging Operations and Environmental Research Program, Todd Bridges, Director. Permission to publish was provided by the Chief of Engineers. NR 49 TC 0 Z9 0 U1 4 U2 10 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0175-8659 EI 1439-0426 J9 J APPL ICHTHYOL JI J. Appl. Ichthyol. PD DEC PY 2015 VL 31 IS 6 BP 984 EP 990 DI 10.1111/jai.12875F PG 7 WC Fisheries; Marine & Freshwater Biology SC Fisheries; Marine & Freshwater Biology GA DA3GE UT WOS:000367684400002 ER PT J AU Eckold, P Sellers, MS Niewa, R Hugel, W AF Eckold, P. Sellers, M. S. Niewa, R. Huegel, W. TI The surface energies of beta-Sn - A new concept for corrosion and whisker mitigation SO MICROELECTRONICS RELIABILITY LA English DT Article DE Surface energy; Tin corrosion; Whisker growth; Electrodeposition; EBSD analysis ID LEAD-FREE SOLDERS; METHANESULFONIC-ACID ELECTROLYTE; TIN-LEAD; NACL SOLUTION; GROWTH; COATINGS; ELECTRODEPOSITION; ELECTRONICS; MECHANISMS; PARAMETERS AB Corrosion data provided under high-temperature and high-humidity conditions as well as tin whisker growth studies are explained by differences in the surface energy of lattice planes within the crystal structure of beta-tin. For this purpose, electrodeposited tin finishes were investigated regarding their microstructure utilizing X-ray diffraction, cross-sectional SEM and EBSD analyses. The corrosion as well as the tin whisker propensity strongly depends on the preferred orientation of the surface finishes. With an increasing texture along the (211) lattice plane a decreasing corrosion and whisker propensity were observed, on the contrary, the presence of the (101) and (112) textures results in an increased corrosion and whisker propensity. The maximum whisker length was reduced by one order of magnitude by changing the preferred orientation towards the (211) lattice plane of the tin finish. Modified embedded atom method simulations of tin surfaces demonstrate the minimization of the surface energy of (211) surfaces, whereas the surface energies of the (101) and (112) Miller planes are increased. We find a strong connection between the minimization of surface energy and the corrosion and tin whisker propensity of electrodeposited tin finishes. To our best knowledge, this is the first study connecting the influence of the electrodeposition parameters on the corrosion and whisker propensity explained by calculations of the surface energies of the corresponding crystal faces. The applied parameters for electrodeposition influence the grain orientation and thus the surface energy of the tin layers which affects both the corrosion as well as the tin whisker propensity. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Eckold, P.; Niewa, R.] Univ Stuttgart, Inst Inorgan Chem, D-70565 Stuttgart, Germany. [Eckold, P.; Huegel, W.] Robert Bosch GmbH, Automot Elect, D-70442 Stuttgart, Germany. [Sellers, M. S.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Eckold, P (reprint author), Univ Stuttgart, Inst Inorgan Chem, Pfaffenwaldring 55, D-70565 Stuttgart, Germany. EM Pierre.Eckold@de.bosch.com FU Robert Bosch GmbH FX The authors would like to thank the Robert Bosch GmbH for providing the financial support for this research in the scope of a PhD study. M.S. Sellers performed his portion of research independent of U.S. Army Research Laboratory interest and resources, and no financial support was provided by the US. Army Research Laboratory or any United States Government entity. In addition, we are deeply obliged to the electrolyte supplier for providing the required plating chemistries. NR 50 TC 1 Z9 1 U1 4 U2 13 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0026-2714 J9 MICROELECTRON RELIAB JI Microelectron. Reliab. PD DEC PY 2015 VL 55 IS 12 BP 2799 EP 2807 DI 10.1016/j.microrel.2015.08.018 PN B PG 9 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA DA4MF UT WOS:000367773300025 ER PT J AU Leguia, M Loyola, S Rios, J Juarez, D Guevara, C Silva, M Prieto, K Wiley, M Kasper, MR Palacios, G Bausch, DG AF Leguia, Mariana Loyola, Steev Rios, Jane Juarez, Diana Guevara, Carolina Silva, Maria Prieto, Karla Wiley, Michael Kasper, Matthew R. Palacios, Gustavo Bausch, Daniel G. TI Full Genomic Characterization of a Saffold Virus Isolated in Peru SO PATHOGENS LA English DT Article DE Saffold virus; Cardiovirus; full genome; Peru ID ENCEPHALOMYOCARDITIS VIRUS; RESPIRATORY PATHOGENS; DIVERSITY; ILLNESS AB While studying respiratory infections of unknown etiology we detected Saffold virus in an oropharyngeal swab collected from a two-year-old female suffering from diarrhea and respiratory illness. The full viral genome recovered by deep sequencing showed 98% identity to a previously described Saffold strain isolated in Japan. Phylogenetic analysis confirmed the Peruvian Saffold strain belongs to genotype 3 and is most closely related to strains that have circulated in Asia. This is the first documented case report of Saffold virus in Peru and the only complete genomic characterization of a Saffold-3 isolate from the Americas. C1 [Leguia, Mariana; Loyola, Steev; Rios, Jane; Juarez, Diana; Guevara, Carolina; Silva, Maria; Kasper, Matthew R.; Bausch, Daniel G.] US Naval Med Res Unit No 6 NAMRU 6, Callao 2, Peru. [Prieto, Karla; Wiley, Michael; Palacios, Gustavo] US Army, Med Res Inst Infect Dis, Ctr Genome Sci, Frederick, MD 21702 USA. [Bausch, Daniel G.] Tulane Sch Publ Hlth & Trop Med, New Orleans, LA 70112 USA. RP Leguia, M (reprint author), US Naval Med Res Unit No 6 NAMRU 6, Callao 2, Peru. EM mariana.leguia.fn@mail.mil; steev.loyola@med.navy.mil; jane.s.rios.fn@mail.mil; diana.s.juarez2.fn@mail.mil; carolina.guevara.fn@mail.mil; maria.e.silva19.fn@mail.mil; karla.prieto.ctr@mail.mil; michael.r.wiley19.ctr@mail.mil; matthew.r.kasper2.mil@mail.mil; gustavo.f.palacios.ctr@mail.mil; bauschd@who.int RI Palacios, Gustavo/I-7773-2015 OI Palacios, Gustavo/0000-0001-5062-1938 NR 19 TC 1 Z9 1 U1 0 U2 2 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 2076-0817 J9 PATHOGENS JI Pathogens PD DEC PY 2015 VL 4 IS 4 BP 816 EP 825 DI 10.3390/pathogens4040816 PG 10 WC Microbiology SC Microbiology GA DA1EI UT WOS:000367538700008 PM 26610576 ER PT J AU Travis, CMG Altman, DE Genovese, RF AF Travis, Caitlin M. Groeber Altman, Daniel E. Genovese, Raymond F. TI Ketamine administration diminishes operant responding but does not impair conditioned fear SO PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR LA English DT Article DE Conditioned fear; Conditioned suppression; Operant conditioning; Stress processes; Ketamine; PTSD ID METHYL-D-ASPARTATE; NONCOMPETITIVE NMDA ANTAGONIST; POSTTRAUMATIC-STRESS-DISORDER; RESISTANT MAJOR DEPRESSION; LONG-TERM POTENTIATION; LOW-DOSE KETAMINE; ANESTHETIC KETAMINE; INTRAVENOUS KETAMINE; RECOGNITION MEMORY; TASTE-AVERSION AB While not well understood, the NMDA (N-methyl-D-aspartate) antagonist ketamine, a dissociative anesthetic, has been reported to be efficacious in depression and related psychological disorders. Conditioned fear is a normal emotional conditioning process that is known to become dysfunctional in individuals suffering from Post-Traumatic Stress Disorder (PTSD) and related stress disorders. We examined the effects of ketamine to determine the potential modulation of the acquisition and extinction of a conditioned fear using a conditioned suppression procedure. Rats were trained on a variable interval (VI), food maintained, operant conditioning task to establish a general measure of performance. Rats were exposed to inescapable shock (IES, unconditioned stimulus) paired (x20) with an audio/visual conditioned stimulus (CS) to establish conditioning. Conditioning was quantified by measuring response suppression following CS presentation during subsequent extinction trials where the CS alone was presented. Ketamine or vehicle was administered either after initial conditioning or after each of the subsequent extinction trials. For each regimen, a series of four injections were administered 60 min apart (100, 50, 50, 50 mg/kg, respectively) in order to sustain a ketamine effect for a minimum of 4 h. Ketamine produced a general decrease in responding on the VI, relative to baseline, as response rates were slower on the operant task when tested 24 h later and longer. Ketamine did not affect the acquisition of the conditioned fear when the regimen was administered shortly after the initial pairings of IES and CS. Ketamine did not alter extinction to the conditioned fear when the regimen was administered following each CS only presentation following initial conditioning. Our conclusion from these findings is that while ketamine alters behavior on an appetitively motivated operant task it does not, however, appear to directly modulate learning and memory processes associated with conditioned fear. (C) 2015 Elsevier Inc. All rights reserved. C1 [Travis, Caitlin M. Groeber; Altman, Daniel E.; Genovese, Raymond F.] Walter Reed Army Inst Res, Behav Biol Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. RP Travis, CMG (reprint author), Walter Reed Army Inst Res, Behav Biol Branch, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM caitlin.m.travis.ctr@mail.mil OI Travis, Caitlin/0000-0002-0113-4225 FU Military Operational Medicine Research Program (MOMRP, Task Area W2), U.S. Army Material Research and Materiel Command FX This research was supported by the Military Operational Medicine Research Program (MOMRP; Task Area W2), U.S. Army Material Research and Materiel Command. Material has been reviewed by the Walter Reed Army Institute of Research. There is no objection to its presentation and/or publication. The opinions or assertions contained herein are the private views of the author, and are not to be construed as official, or as reflecting true views of the Department of the Army or the Department of Defense. NR 60 TC 2 Z9 2 U1 4 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0091-3057 J9 PHARMACOL BIOCHEM BE JI Pharmacol. Biochem. Behav. PD DEC PY 2015 VL 139 BP 84 EP 91 DI 10.1016/j.pbb.2015.10.013 PN A PG 8 WC Behavioral Sciences; Neurosciences; Pharmacology & Pharmacy SC Behavioral Sciences; Neurosciences & Neurology; Pharmacology & Pharmacy GA DA4LX UT WOS:000367772500010 ER PT J AU Borch, FL AF Borch, Fred L. TI Murder in Manila SO PROLOGUE-QUARTERLY OF THE NATIONAL ARCHIVES AND RECORDS ADMINISTRATION LA English DT Article C1 [Borch, Fred L.] Armys Judge Advocate Generals Corps, Ft Bliss, TX 79916 USA. RP Borch, FL (reprint author), Armys Judge Advocate Generals Corps, Ft Bliss, TX 79916 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATL ARCHIVES RECORDS ADMINISTRATION PI WASHINGTON PA TRUST FUND BOARD, WASHINGTON, DC 20408 USA SN 0033-1031 J9 PROLOGUE JI Prologue PD WIN PY 2015 VL 47 IS 4 BP 6 EP 14 PG 9 WC History SC History GA DA4HS UT WOS:000367761600003 ER PT J AU Trefry, JC Wollen, SE Nasar, F Shamblin, JD Kern, SJ Bearss, JJ Jefferson, MA Chance, TB Kugelman, JR Ladner, JT Honko, AN Kobs, DJ Wending, MQS Sabourin, CL Pratt, WD Palacios, GF Pitt, MLM AF Trefry, John C. Wollen, Suzanne E. Nasar, Farooq Shamblin, Joshua D. Kern, Steven J. Bearss, Jeremy J. Jefferson, Michelle A. Chance, Taylor B. Kugelman, Jeffery R. Ladner, Jason T. Honko, Anna N. Kobs, Dean J. Wending, Morgan Q. S. Sabourin, Carol L. Pratt, William D. Palacios, Gustavo F. Pitt, M. Louise M. TI Ebola Virus Infections in Nonhuman Primates Are Temporally Influenced by Glycoprotein Poly-U Editing Site Populations in the Exposure Material SO VIRUSES-BASEL LA English DT Article DE Ebola virus; Kikwit; filovirus; nonhuman primate; glycoprotein; RNA editing; pathogenesis; animal model; vaccine; therapeutic ID HEMORRHAGIC-FEVER; MARBURG VIRUSES; POSTEXPOSURE PROTECTION; DISEASE; VACCINE; RNA; CHALLENGE; MODELS; PATHOGENESIS; SURVIVAL AB Recent experimentation with the variants of the Ebola virus that differ in the glycoprotein's poly-uridine site, which dictates the form of glycoprotein produced through a transcriptional stutter, has resulted in questions regarding the pathogenicity and lethality of the stocks used to develop products currently undergoing human clinical trials to combat the disease. In order to address these concerns and prevent the delay of these critical research programs, we designed an experiment that permitted us to intramuscularly challenge statistically significant numbers of naive and vaccinated cynomolgus macaques with either a 7U or 8U variant of the Ebola virus, Kikwit isolate. In naive animals, no difference in survivorship was observed; however, there was a significant delay in the disease course between the two groups. Significant differences were also observed in time-of-fever, serum chemistry, and hematology. In vaccinated animals, there was no statistical difference in survivorship between either challenge groups, with two succumbing in the 7U group compared to 1 in the 8U challenge group. In summary, survivorship was not affected, but the Ebola virus disease course in nonhuman primates is temporally influenced by glycoprotein poly-U editing site populations. C1 [Trefry, John C.; Wollen, Suzanne E.; Nasar, Farooq; Shamblin, Joshua D.; Kern, Steven J.; Honko, Anna N.; Pratt, William D.; Pitt, M. Louise M.] US Army, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. [Bearss, Jeremy J.; Jefferson, Michelle A.; Chance, Taylor B.] US Army, Med Res Inst Infect Dis, Div Pathol, Fort Detrick, MD 21702 USA. [Kugelman, Jeffery R.; Ladner, Jason T.; Palacios, Gustavo F.] US Army, Med Res Inst Infect Dis, Mol & Translat Sci, Fort Detrick, MD 21702 USA. [Kobs, Dean J.; Wending, Morgan Q. S.; Sabourin, Carol L.] Battelle Mem Inst, Columbus, OH 43201 USA. RP Trefry, JC (reprint author), US Army, Med Res Inst Infect Dis, Div Virol, 1425 Porter St, Ft Detrick, MD 21702 USA. EM john.c.trefry.ctr@mail.mil; suzanne.e.wollen.ctr@mail.mil; farooq.nasar.ctr@mail.mil; joshua.d.shamblin.civ@mail.mil; kern.steven0@gmail.com; jeremy.j.bearss.mil@mail.mil; michelle.a.jefferson.mil@mail.mil; taylor.b.chance.mil@mail.mil; jeffery.r.kugelman.mil@mail.mil; jason.t.ladner.ctr@mail.mil; anna.honko@nih.gov; kobsd@battelle.org; wendingm@battelle.org; SabourinC@battelle.org; william.d.pratt.civ@mail.mil; gustavo.f.palacios.ctr@mail.mil; margaret.l.pitt.civ@mail.mil RI Palacios, Gustavo/I-7773-2015; OI Palacios, Gustavo/0000-0001-5062-1938; Honko, Anna/0000-0001-9165-148X FU Medical Countermeasures Systems Joint Vaccine Acquisition Program (MCS-JVAP) FX The authors would like to acknowledge the Medical Countermeasures Systems Joint Vaccine Acquisition Program (MCS-JVAP) for funding this study. NR 54 TC 4 Z9 4 U1 1 U2 7 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1999-4915 J9 VIRUSES-BASEL JI Viruses-Basel PD DEC PY 2015 VL 7 IS 12 BP 6739 EP 6754 DI 10.3390/v7122969 PG 16 WC Virology SC Virology GA DA1DO UT WOS:000367536700044 PM 26703716 ER PT J AU Liu, NT Salinas, J AF Liu, Nehemiah T. Salinas, Jose TI Machine learning in burn care and research: A systematic review of the literature SO BURNS LA English DT Review DE Machine learning; Neural networks; Mortality prediction; Burn care; Burn wounds ID ARTIFICIAL NEURAL-NETWORKS; PREDICTION; MEDICINE; CLASSIFICATION; SURVIVAL; INTELLIGENCE; INFORMATION; DIAGNOSIS; COMPUTER; BRAIN AB Background: To date, there are no reviews on machine learning (ML) in burn care. Considering the growth of ML in medicine and the complexities and challenges of burn care, this review specializes on ML applications in burn care. The objective was to examine the features and impact of applications in targeting various aspects of burn care and research. Methods: MEDLINE, the Cochrane Database of Systematic Reviews, Science Direct, and citation review of relevant primary and review articles were searched for studies involving burn care/research and machine learning. Data were abstracted on study design, study size, year, population, application of burn care/research, ML technique(s), and algorithm performance. Results: 15 retrospective observational studies involving burn patients met inclusion criteria. In total 5105 patients with acute thermal injury, 171 clinical burn wounds, 180 9-mer peptides, and 424 12-mer peptides were included in the studies. Studies focused on burn diagnosis (n = 5), aminoglycoside response (n = 3), hospital length of stay (n = 2), survival/mortality (n = 4), burn healing time (n = 1), and antimicrobial peptides in burn patients (n = 1). Of these 15 studies, 11 used artificial neural networks. Importantly, all studies demonstrated the benefits of ML in burn care/research and superior performance over traditional statistical methods. However, algorithm performance was assessed differently by different authors. Feature selection varied among studies, but studies with similar applications shared specific features including age, gender, presence of inhalation injury, total body surface area burned, and when available, various degrees of burns, infections, and previous histories/conditions of burn patients. Conclusion: A common feature base may be determined for ML in burn care/research, but the impact of ML will require further validation in prospective observational studies and randomized clinical trials, establishment of common performance metrics, and high quality evidence about clinical and economic impacts. Only then can ML applications be advanced and accepted widely in burn care/research. (C) 2015 Elsevier Ltd and ISBI. All rights reserved. C1 [Liu, Nehemiah T.; Salinas, Jose] US Army Inst Surg Res, Ft Sam Houston, TX USA. RP Liu, NT (reprint author), US Army Inst Surg Res, 3698 Chambers Pass, Jbsa Ft Sam Houston, TX 78234 USA. EM nehemiah.liu@us.army.mil; jose.salinas4@us.army.mil FU U.S. Army Combat Casualty Care Research Program FX This work was supported by the U.S. Army Combat Casualty Care Research Program. NR 36 TC 1 Z9 1 U1 2 U2 8 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 EI 1879-1409 J9 BURNS JI Burns PD DEC PY 2015 VL 41 IS 8 BP 1636 EP 1641 DI 10.1016/j.burns.2015.07.001 PG 6 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA CZ5FK UT WOS:000367127700003 PM 26233900 ER PT J AU Nyland, JE McLean, SA Averitt, DL AF Nyland, Jennifer E. McLean, Samuel A. Averitt, Dayna L. TI Prior stress exposure increases pain behaviors in a rat model of full thickness thermal injury SO BURNS LA English DT Article DE Bum pain; Thermal injury; Hyperalgesia; Allodynia; Stress ID PITUITARY-ADRENAL AXIS; LASTING DELAYED HYPERALGESIA; CHRONIC-FATIGUE-SYNDROME; REPEATED COLD STRESS; SWIM STRESS; GLUCOCORTICOID-RECEPTOR; MECHANICAL ALLODYNIA; BURN PATIENTS; DULOXETINE; EXPRESSION AB Thermal burns among individuals working in highly stressful environments, such as firefighters and military Service Members, are common. Evidence suggests that pre-injury stress may exaggerate pain following thermal injury; however current animal models of burn have not evaluated the potential influence of pre-burn stress. This sham-controlled study evaluated the influence of prior stress exposure on post-bum thermal and mechanical sensitivity in male Sprague-Dawley rats. Rats were exposed to 20 mm of inescapable swim stress or sham stress once per day for three days. Exposure to inescapable swim stress (1) increased the intensity and duration of thermal hyperalgesia after subsequent burn and (2) accelerated the onset of thermal hyperalgesia and mechanical allodynia after subsequent burn. This stress-induced exacerbation of pain sensitivity was reversed by pretreatment and concurrent treatment with the serotonin-norepinephrine reuptake inhibitor (SNRI) duloxetine. These data suggest a better understanding of mechanisms by which prior stress augments pain after thermal burn may lead to improved pain treatments for burn survivors. (C) 2015 Elsevier Ltd and ISBI. All rights reserved. C1 [Nyland, Jennifer E.] US Army Inst Surg Res, Pain Management Res Area, Ft Sam Houston, TX USA. [McLean, Samuel A.] Univ N Carolina, Dept Anesthesiol, Chapel Hill, NC USA. [McLean, Samuel A.] Univ N Carolina, Dept Emergency Med, Chapel Hill, NC USA. [Averitt, Dayna L.] Texas Womans Univ, Dept Biol, Denton, TX 76204 USA. RP Nyland, JE (reprint author), US Army Inst Surg Res, Pain Management Res Area, 3698 Chambers Pass, Jbsa Ft Sam Houston, TX 78234 USA. EM jen.e.nyland@gmail.com OI Averitt, Dayna/0000-0001-8345-4988 FU United States Army Medical Research and Materiel Command Combat Casualty Care Research; Clinical and Rehabilitative Medicine Research programs FX This work was supported by the United States Army Medical Research and Materiel Command Combat Casualty Care Research and the Clinical and Rehabilitative Medicine Research programs. The authors would like to acknowledge LTC Lawrence Petz, Dr. John Clifford, and Dr. Marcie Fowler for reviewing earlier versions of this manuscript and Dr. James Aden for help with statistical analyses. NR 42 TC 0 Z9 0 U1 0 U2 6 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 EI 1879-1409 J9 BURNS JI Burns PD DEC PY 2015 VL 41 IS 8 BP 1796 EP 1804 DI 10.1016/j.burns.2015.09.007 PG 9 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA CZ5FK UT WOS:000367127700021 PM 26432505 ER PT J AU Fletcher, JL Cancio, LC Sinha, I Leung, KP Evan, MRA Chan, RK AF Fletcher, John L. Cancio, Leopoldo C. Sinha, Indranil Leung, Kai P. Renz, Evan M. Chan, Rodney K. TI Inability to determine tissue health is main indication of allograft use in intermediate extent burns SO BURNS LA English DT Article DE Cryopreserved allograft skin; Autograft failure; Tissue health; Depth of excision ID ENDURING FREEDOM; DEPTH ASSESSMENT; LASER-DOPPLER; SKIN ALLOGRAFTS; ALLOGENIC SKIN; CADAVERIC SKIN; IRAQI FREEDOM; BANK; EXPERIENCE; VIABILITY AB Introduction: Cutaneous allograft is commonly used in the early coverage of excised burns when autograft is unavailable. However, allograft is also applied in intermediate-extent burns (25-50%), during cases in which it is possible to autograft. In this population, there is a paucity of data on the indications for allograft use. This study explores the indications for allograft usage in moderate size burns. Methods: Under an IRB-approved protocol, patients admitted to our burn unit between March 2003 and December 2010 were identified through a review of the burn registry. Data on allograft use, total burn surface area, operation performed, operative intent, number of operations, intensive care unit length of stay, and overall length of stay were collected and analyzed. Data are presented as means standard deviations, except where noted. Results: In the study period, 146 patients received allograft during their acute hospitalization. Twenty-five percent of allograft recipients sustained intermediate-extent burns. Patients with intermediate-extent burns received allograft later in their hospitalization than those with large-extent (50-75% TBSA) burns (6.8 days vs. 3.4 days, p = 0.01). Allografted patients with intermediate-extent burns underwent more operations (10.8 vs. 6.1, p = 0.002) and had longer hospitalizations (78.3 days vs. 40.9 days, p < 0.001) than non-allografted patients, when controlled for TBSA. Clinical rationale for placement of allograft in this population included autograft failure, uncertain depth of excision, lack of autograft donor site, and wound complexity. When uncertain depth of excision was the indication, allograft was universally applied onto the face. In half of allografted intermediate-extent burn patients the inability to identify a viable recipient bed was the ultimate reason for allograft use. Conclusions: Unlike large body surface area burns, allograft skin use in intermediate-extent injury occurs later in the hospitalization and is driven by the inability to determine wound bed suitability for autograft application. Allograft application can be utilized to test recipient site viability in cases of autograft failure or uncertain depth of excision. Published by Elsevier Ltd and ISBI C1 [Fletcher, John L.; Renz, Evan M.] Brooke Army Med Ctr, Jbsa Ft Sam Houston, TX 78234 USA. [Fletcher, John L.; Cancio, Leopoldo C.; Chan, Rodney K.] US Army Inst Surg Res, Clin Div, Ft Sam Houston, TX 78234 USA. [Fletcher, John L.; Cancio, Leopoldo C.; Chan, Rodney K.] US Army Inst Surg Res, Burn Ctr, Ft Sam Houston, TX 78234 USA. [Fletcher, John L.; Leung, Kai P.; Chan, Rodney K.] US Army Inst Surg Res, Dent & Trauma Res Detachment, Ft Sam Houston, TX 78234 USA. [Sinha, Indranil] Brigham & Womens Hosp, Div Plast Surg, Boston, MA 02115 USA. RP Chan, RK (reprint author), US Army Inst Surg Res, Clin Div, 3650 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM rodney.k.chan@us.army.mil FU U.S. Army Medical Research and Material Command FX This work was funded by the U.S. Army Medical Research and Material Command. NR 49 TC 1 Z9 1 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 EI 1879-1409 J9 BURNS JI Burns PD DEC PY 2015 VL 41 IS 8 BP 1862 EP 1867 DI 10.1016/j.burns.2015.09.006 PG 6 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA CZ5FK UT WOS:000367127700030 PM 26471053 ER PT J AU Wang, ZT Fang, SC Lavery, JE AF Wang, Ziteng Fang, Shu-Cherng Lavery, John E. TI On shape-preserving capability of cubic L-1 spline fits SO COMPUTER AIDED GEOMETRIC DESIGN LA English DT Article DE L-1 spline; Shape preservation; Approximation; Spline fit; Univariate ID GEOMETRIC-PROGRAMMING APPROACH; L-P SPLINES; MULTISCALE INTERPOLATION; BIVARIATE; CURVES AB Cubic L-1 spline fits have shown some favorable shape-preserving property for geometric data. To quantify the shape-preserving capability, we consider the basic shape of two parallel line segments in a given window. When one line segment is sufficiently longer than the other, the spline fit can preserve its linear shape in at least half of the window. We propose to use the minimum of such length difference as a shape-preserving metric because it represents the extra information that the spline fits need to preserve the shape. We analytically calculate this metric in a 3-node window for second-derivativebased, first-derivative-based and function-value-based spline fits. In a 5-node window, we compute this metric numerically. In both cases, the shape-preserving metric is rather small, which explains the observed strong shape-preserving capability of spline fits. Moreover, the function-value-based spline fits are indicated to preserve shape better than the other two types of spline fits. This study initiates a quantitative research on shape preservation of L-1 spline fits. (C) 2015 Elsevier B.V. All rights reserved. C1 [Wang, Ziteng; Fang, Shu-Cherng] N Carolina State Univ, Edward P Fitts Dept Ind & Syst Engn, Raleigh, NC 27695 USA. [Lavery, John E.] US Army, Res Off, Army Res Lab, Div Mat Sci, Res Triangle Pk, NC 27709 USA. [Lavery, John E.] US Army, Res Off, Army Res Lab, Div Comp Sci, Res Triangle Pk, NC 27709 USA. RP Wang, ZT (reprint author), N Carolina State Univ, Edward P Fitts Dept Ind & Syst Engn, Raleigh, NC 27695 USA. EM zwang23@ncsu.edu; fang@ncsu.edu; john.e.lavery4.civ@mail.mil OI Wang, Ziteng/0000-0001-7763-8959 FU US Army Research Office [W911NF-04-D-0003, W911NF-15-1-0223]; North Carolina State University Edward P. Fitts Fellowship; US NSF [DMI-0553310]; Army Research Office FX This work was generously supported by US Army Research Office Grants # W911NF-04-D-0003 and #W911NF-15-1-0223, by the North Carolina State University Edward P. Fitts Fellowship and by US NSF Grant # DMI-0553310. It is the policy of the Army Research Office that university personnel do not need to do joint work with ARO personnel in order to receive grants from the Army Research Office. NR 21 TC 0 Z9 0 U1 2 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-8396 EI 1879-2332 J9 COMPUT AIDED GEOM D JI Comput. Aided Geom. Des. PD DEC PY 2015 VL 40 BP 59 EP 75 DI 10.1016/j.cagd.2015.09.004 PG 17 WC Computer Science, Software Engineering; Mathematics, Applied SC Computer Science; Mathematics GA CZ5CY UT WOS:000367121300004 ER PT J AU DeGregorio, BA Sperry, JH Ward, MP Weatherhead, PJ AF DeGregorio, Brett A. Sperry, Jinelle H. Ward, Michael P. Weatherhead, Patrick J. TI Wait Until Dark? Daily Activity Patterns and Nest Predation by Snakes SO ETHOLOGY LA English DT Article DE automated radiotelemetry; facultative nocturnal; foraging; predatory tactics; nest cameras; nocturnal activity ID BLACK RAT SNAKES; SEASONAL-VARIATION; ELAPHE-OBSOLETA; SONGBIRD NESTS; RISK; PREY; BEHAVIOR; MORTALITY; TELEMETRY; RATSNAKES AB Predation involves costs and benefits, so predators should employ tactics that reduce their risk of injury or death and that increase their success at capturing prey. One potential way that predators could decrease risk and increase benefits is by attacking prey at night when risks may be reduced and prey more vulnerable. Because some snakes are facultatively nocturnal and prey on bird nests during the day and night, they are ideal for assessing the costs and benefits of diurnal vs. nocturnal predation. We used automated radiotelemetry and cameras to investigate predation on nesting birds by two species of snakes, one diurnal and the other facultatively nocturnal. We predicted that snakes preying on nests at night should experience less parental nest defence and capture more adults and nestlings. Rat snakes (Pantherophis obsoletus) were relatively inactive at night (23-36% activity) but nearly always preyed on nests after dark (80% of nest predations). Conversely, racers (Coluber constrictor) were exclusively diurnal and preyed on nests during the times of day they were most active. These results are consistent with rat snakes strategically using their capacity for facultative nocturnal activity to prey on nests at night. The likely benefit is reduced nest defence because birds defended their nests less vigourously at night. Consistent with nocturnal predation being safer, rat snake predation events lasted three times longer at night than during the day (26 vs. 8 min). Nocturnal nest predation did not make nests more profitable by increasing the likelihood of capturing adults or removing premature fledging of nestlings. The disconnect between rat snake activity and timing of nest predation seems most consistent with rat snakes locating prey during the day using visual cues but waiting until dark to prey on nests when predation is safer, although designing a direct test of this hypothesis will be challenging. C1 [DeGregorio, Brett A.; Sperry, Jinelle H.] US Army Corps Engineers, ERDC CERL, Champaign, IL 61826 USA. [DeGregorio, Brett A.; Sperry, Jinelle H.; Ward, Michael P.; Weatherhead, Patrick J.] Univ Illinois, Urbana, IL 61801 USA. RP DeGregorio, BA (reprint author), US Army Corps Engineers, ERDC CERL, 2902 Newmark Dr, Champaign, IL 61826 USA. EM badegregorio@gmail.com FU Construction Engineering Research Laboratory of the Engineer Research Development Center FX Funding was provided by the Construction Engineering Research Laboratory of the Engineer Research Development Center. We thank Tim Hayden for arranging funding. Special thanks to the Savannah River Ecology Laboratory for hosting us especially Tracey Tuberville and Brian Metts. We thank of all our excellent technicians including Eric Nordberg, Mary Mack Gray, Ashley Smith, Patrick Barnhart, Patrick Roberts, Phil Vogrinc, Emily Williams, Mae Cowgill, Sara Wendt, Clay Noss and Andrew Cronin. We would like to thank Scott Chiavacci for assistance in building automated radiotelemetry towers and Kirk Stodola for his assistance with analyses. We also thank Dr. Jason Norman and the Hammond Hills Animal Hospital for transmitter surgeries. Animals were collected under SC Department of Natural Resources permits # G-11-03 and 23-2012A. Animal procedures conformed to permits approved by the University of Illinois (IACUC #11054) and University of Georgia (AUP #A2011 04-007-Y2-A0). NR 44 TC 0 Z9 0 U1 8 U2 25 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0179-1613 EI 1439-0310 J9 ETHOLOGY JI Ethology PD DEC PY 2015 VL 121 IS 12 BP 1225 EP 1234 DI 10.1111/eth.12435 PG 10 WC Psychology, Biological; Behavioral Sciences; Zoology SC Psychology; Behavioral Sciences; Zoology GA CZ4WL UT WOS:000367103400009 ER PT J AU Gao, JH Zhao, Q Ren, W Swami, A Ramanathan, R Bar-Noy, A AF Gao, Jianhang Zhao, Qing Ren, Wei Swami, Ananthram Ramanathan, Ram Bar-Noy, Amotz TI Dynamic Shortest Path Algorithms for Hypergraphs SO IEEE-ACM TRANSACTIONS ON NETWORKING LA English DT Article DE Dynamic; hypergraph; hyperpath; shortest path AB A hypergraph is a set of vertices and a set of nonempty subsets of, called hyperedges. Unlike graphs, hypergraphs can capture higher-order interactions in social and communication networks that go beyond a simple union of pair-wise relationships. In this paper, we consider the shortest path problem in hypergraphs. We develop two algorithms for finding and maintaining the shortest hyperpaths in a dynamic network with both weight and topological changes. These two algorithms are the first to address the fully dynamic shortest path problem in a general hypergraph. They complement each other by partitioning the application space based on the nature of the change dynamics and the type of the hypergraph. We analyze the time complexity of the proposed algorithms and perform simulation experiments for random geometric hypergraphs, energy efficient routing in multichannel multiradio networks, and the Enron email data set. The experiment with the Enron email data set illustrates the application of the proposed algorithms in social networks for identifying the most important actor and the latent social relationship based on the closeness centrality metric. C1 [Gao, Jianhang; Zhao, Qing] Univ Calif Davis, Dept Elect & Comp Engn, Davis, CA 95618 USA. [Ren, Wei] Microsoft Corp, Redmond, WA 98052 USA. [Swami, Ananthram] Army Res Lab, Adelphi, MD 20783 USA. [Ramanathan, Ram] Raytheon BBN Technol, Cambridge, MA 02138 USA. [Bar-Noy, Amotz] CUNY, Dept Comp Sci, Brooklyn, NY 11210 USA. RP Gao, JH (reprint author), Univ Calif Davis, Dept Elect & Comp Engn, Davis, CA 95618 USA. EM jhgao@ucdavis.edu FU Army Research Laboratory Network Science CTA [W911NF-09-2-0053] FX This work was supported by the Army Research Laboratory Network Science CTA under Cooperative Agreement W911NF-09-2-0053. NR 15 TC 0 Z9 0 U1 6 U2 6 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1063-6692 EI 1558-2566 J9 IEEE ACM T NETWORK JI IEEE-ACM Trans. Netw. PD DEC PY 2015 VL 23 IS 6 BP 1805 EP 1817 DI 10.1109/TNET.2014.2343914 PG 13 WC Computer Science, Hardware & Architecture; Computer Science, Theory & Methods; Engineering, Electrical & Electronic; Telecommunications SC Computer Science; Engineering; Telecommunications GA CZ4VM UT WOS:000367100900009 ER PT J AU Sampson, JN Wheeler, WA Yeager, M Panagiotou, O Wang, Z Berndt, SI Lan, Q Abnet, CC Amundadottir, LT Figueroa, JD Landi, MT Mirabello, L Savage, SA Taylor, PR De Vivo, I McGlynn, KA Purdue, MP Rajaraman, P Adami, HO Ahlbom, A Albanes, D Amary, MF An, SJ Andersson, U Andriole, G Andrulis, IL Angelucci, E Ansell, SM Arici, C Armstrong, BK Arslan, AA Austin, MA Baris, D Barkauskas, DA Bassig, BA Becker, N Benavente, Y Benhamou, S Berg, C Van Den Berg, D Bernstein, L Bertrand, KA Birmann, BM Black, A Boeing, H Boffetta, P Boutron-Ruault, MC Bracci, PM Brinton, L Brooks-Wilson, AR Bueno-De-Mesquita, HB Burdett, L Buring, J Butler, MA Cai, QY Cancel-Tassin, G Canzian, F Carrato, A Carreon, T Carta, A Chan, JKC Chang, ET Chang, GC Chang, IS Chang, J Chang-Claude, J Chen, CJ Chen, CY Chen, C Chen, CH Chen, C Chen, HY Chen, KX Chen, KY Chen, KC Chen, Y Chen, YH Chen, YS Chen, YM Chien, LH Chirlaque, MD Choi, JE Choi, YY Chow, WH Chung, CC Clavel, J Clavel-Chapelon, F Cocco, P Colt, JS Comperat, E Conde, L Connors, JM Conti, D Cortessis, VK Cotterchio, M Cozen, W Crouch, S Crous-Bou, M Cussenot, O Davis, FG Ding, T Diver, WR Dorronsoro, M Dossus, L Duell, EJ Ennas, MG Erickson, RL Feychting, M Flanagan, AM Foretova, L Fraumeni, JF Freedman, ND Freeman, LEB Fuchs, C Gago-Dominguez, M Gallinger, S Gao, YT Gapstur, SM Garcia-Closas, M Garcia-Closas, R Gascoyne, RD Gastier-Foster, J Gaudet, MM Gaziano, JM Giffen, C Giles, GG Giovannucci, E Glimelius, B Goggins, M Gokgoz, N Goldstein, AM Gorlick, R Gross, M Grubb, R Gu, J Guan, P Gunter, M Guo, H Habermann, TM Haiman, CA Halai, D Hallmans, G Hassan, M Hattinger, C He, QC He, XZ Helzlsouer, K Henderson, B Henriksson, R Hjalgrim, H Hoffman-Bolton, J Hohensee, C Holford, TR Holly, EA Hong, YC Hoover, RN Horn-Ross, PL Hosain, GMM Hosgood, HD Hsiao, CF Hu, N Hu, W Hu, ZB Huang, MS Huerta, JM Hung, JY Hutchinson, A Inskip, PD Jackson, RD Jacobs, EJ Jenab, M Jeon, HS Ji, BT Jin, GF Jin, L Johansen, C Johnson, A Jung, YJ Kaaks, R Kamineni, A Kane, E Kang, CH Karagas, MR Kelly, RS Khaw, KT Kim, C Kim, HN Kim, JH Kim, JS Kim, YH Kim, YT Kim, YC Kitahara, CM Klein, AP Klein, RJ Kogevinas, M Kohno, T Kolonel, LN Kooperberg, C Kricker, A Krogh, V Kunitoh, H Kurtz, RC Kweon, SS LaCroix, A Lawrence, C Lecanda, F Lee, VHF Li, DH Li, HX Li, JH Li, YJ Li, YQ Liao, LM Liebow, M Lightfoot, T Lim, WY Lin, CC Lin, DX Lindstrom, S Linet, MS Link, BK Liu, CW Liu, JJ Liu, L Ljungberg, B Lloreta, J Di Lollo, S Lu, D Lund, E Malats, N Mannisto, S Le Marchand, L Marina, N Masala, G Mastrangelo, G Matsuo, K Maynadie, M Mckay, J McKean-Cowdin, R Melbye, M Melin, BS Michaud, DS Mitsudomi, T Monnereau, A Montalvan, R Moore, LE Mortensen, LM Nieters, A North, KE Novak, AJ Oberg, AL Offit, K Oh, IJ Olson, SH Palli, D Pao, W Park, IK Park, JY Park, KH Patino-Garcia, A Pavanello, S Peeters, PHM Perng, RP Peters, U Petersen, GM Picci, P Pike, MC Porru, S Prescott, J Prokunina-Olsson, L Qian, B Qiao, YL Rais, M Riboli, E Riby, J Risch, HA Rizzato, C Rodabough, R Roman, E Roupret, M Ruder, AM de Sanjose, S Scelo, G Schned, A Schumacher, F Schwartz, K Schwenn, M Scotlandi, K Seow, A Serra, C Serra, M Sesso, HD Setiawan, VW Severi, G Severson, RK Shanafelt, TD Shen, HB Shen, W Shin, MH Shiraishi, K Shu, XO Siddiq, A Sierrasesumaga, L Sihoe, ADL Skibola, CF Smith, A Smith, MT Southey, MC Spinelli, JJ Staines, A Stampfer, M Stern, MC Stevens, VL Stolzenberg-Solomon, RS Su, J Su, WC Sund, M Sung, JS Sung, SW Tan, W Tang, W Tardon, A Thomas, D Thompson, CA Tinker, LF Tirabosco, R Tjonneland, A Travis, RC Trichopoulos, D Tsai, FY Tsai, YH Tucker, M Turner, J Vajdic, CM Vermeulen, RCH Villano, DJ Vineis, P Virtamo, J Visvanathan, K Wactawski-Wende, J Wang, CY Wang, CL Wang, JC Wang, JW Wei, FS Weiderpass, E Weiner, GJ Weinstein, S Wentzensen, N White, E Witzig, TE Wolpin, BM Wong, MP Wu, C Wu, GP Wu, JJ Wu, TC Wu, W Wu, XF Wu, YL Wunder, JS Xiang, YB Xu, J Xu, P Yang, PC Yang, TY Ye, YQ Yin, ZH Yokota, J Yoon, HI Yu, CJ Yu, H Yu, K Yuan, JM Zelenetz, A Zeleniuch-Jacquotte, A Zhang, XC Zhang, YW Zhao, XY Zhao, ZH Zheng, H Zheng, TZ Zheng, W Zhou, BS Zhu, M Zucca, M Boca, SM Cerhan, JR Ferri, GM Hartge, P Hsiung, CA Magnani, C Miligi, L Morton, LM Smedby, KE Teras, LR Vijai, J Wang, SS Brennan, P Caporaso, NE Hunter, DJ Kraft, P Rothman, N Silverman, DT Slager, SL Chanock, SJ Chatterjee, N AF Sampson, Joshua N. Wheeler, William A. Yeager, Meredith Panagiotou, Orestis Wang, Zhaoming Berndt, Sonja I. Lan, Qing Abnet, Christian C. Amundadottir, Laufey T. Figueroa, Jonine D. Landi, Maria Teresa Mirabello, Lisa Savage, Sharon A. Taylor, Philip R. De Vivo, Immaculata McGlynn, Katherine A. Purdue, Mark P. Rajaraman, Preetha Adami, Hans-Olov Ahlbom, Anders Albanes, Demetrius Amary, Maria Fernanda An, She-Juan Andersson, Ulrika Andriole, Gerald, Jr. Andrulis, Irene L. Angelucci, Emanuele Ansell, Stephen M. Arici, Cecilia Armstrong, Bruce K. Arslan, Alan A. Austin, Melissa A. Baris, Dalsu Barkauskas, Donald A. Bassig, Bryan A. Becker, Nikolaus Benavente, Yolanda Benhamou, Simone Berg, Christine Van Den Berg, David Bernstein, Leslie Bertrand, Kimberly A. Birmann, Brenda M. Black, Amanda Boeing, Heiner Boffetta, Paolo Boutron-Ruault, Marie-Christine Bracci, Paige M. Brinton, Louise Brooks-Wilson, Angela R. Bueno-de-Mesquita, H. Bas Burdett, Laurie Buring, Julie Butler, Mary Ann Cai, Qiuyin Cancel-Tassin, Geraldine Canzian, Federico Carrato, Alfredo Carreon, Tania Carta, Angela Chan, John K. C. Chang, Ellen T. Chang, Gee-Chen Chang, I-Shou Chang, Jiang Chang-Claude, Jenny Chen, Chien-Jen Chen, Chih-Yi Chen, Chu Chen, Chung-Hsing Chen, Constance Chen, Hongyan Chen, Kexin Chen, Kuan-Yu Chen, Kun-Chieh Chen, Ying Chen, Ying-Hsiang Chen, Yi-Song Chen, Yuh-Min Chien, Li-Hsin Chirlaque, Maria-Dolores Choi, Jin Eun Choi, Yi Young Chow, Wong-Ho Chung, Charles C. Clavel, Jacqueline Clavel-Chapelon, Franoise Cocco, Pierluigi Colt, Joanne S. Comperat, Eva Conde, Lucia Connors, Joseph M. Conti, David Cortessis, Victoria K. Cotterchio, Michelle Cozen, Wendy Crouch, Simon Crous-Bou, Marta Cussenot, Olivier Davis, Faith G. Ding, Ti Diver, W. Ryan Dorronsoro, Miren Dossus, Laure Duell, Eric J. Ennas, Maria Grazia Erickson, Ralph L. Feychting, Maria Flanagan, Adrienne M. Foretova, Lenka Fraumeni, Joseph F., Jr. Freedman, Neal D. Freeman, Laura E. Beane Fuchs, Charles Gago-Dominguez, Manuela Gallinger, Steven Gao, Yu-Tang Gapstur, Susan M. Garcia-Closas, Montserrat Garcia-Closas, Reina Gascoyne, Randy D. Gastier-Foster, Julie Gaudet, Mia M. Gaziano, J. Michael Giffen, Carol Giles, Graham G. Giovannucci, Edward Glimelius, Bengt Goggins, Michael Gokgoz, Nalan Goldstein, Alisa M. Gorlick, Richard Gross, Myron Grubb, Robert, III Gu, Jian Guan, Peng Gunter, Marc Guo, Huan Habermann, Thomas M. Haiman, Christopher A. Halai, Dina Hallmans, Goran Hassan, Manal Hattinger, Claudia He, Qincheng He, Xingzhou Helzlsouer, Kathy Henderson, Brian Henriksson, Roger Hjalgrim, Henrik Hoffman-Bolton, Judith Hohensee, Chancellor Holford, Theodore R. Holly, Elizabeth A. Hong, Yun-Chul Hoover, Robert N. Horn-Ross, Pamela L. Hosain, G. M. Monawar Hosgood, H. Dean, III Hsiao, Chin-Fu Hu, Nan Hu, Wei Hu, Zhibin Huang, Ming-Shyan Huerta, Jose-Maria Hung, Jen-Yu Hutchinson, Amy Inskip, Peter D. Jackson, Rebecca D. Jacobs, Eric J. Jenab, Mazda Jeon, Hyo-Sung Ji, Bu-Tian Jin, Guangfu Jin, Li Johansen, Christoffer Johnson, Alison Jung, Yoo Jin Kaaks, Rudolph Kamineni, Aruna Kane, Eleanor Kang, Chang Hyun Karagas, Margaret R. Kelly, Rachel S. Khaw, Kay-Tee Kim, Christopher Kim, Hee Nam Kim, Jin Hee Kim, Jun Suk Kim, Yeul Hong Kim, Young Tae Kim, Young-Chul Kitahara, Cari M. Klein, Alison P. Klein, Robert J. Kogevinas, Manolis Kohno, Takashi Kolonel, Laurence N. Kooperberg, Charles Kricker, Anne Krogh, Vittorio Kunitoh, Hideo Kurtz, Robert C. Kweon, Sun-Seog LaCroix, Andrea Lawrence, Charles Lecanda, Fernando Lee, Victor Ho Fun Li, Donghui Li, Haixin Li, Jihua Li, Yao-Jen Li, Yuqing Liao, Linda M. Liebow, Mark Lightfoot, Tracy Lim, Wei-Yen Lin, Chien-Chung Lin, Dongxin Lindstrom, Sara Linet, Martha S. Link, Brian K. Liu, Chenwei Liu, Jianjun Liu, Li Ljungberg, Boerje Lloreta, Josep Di Lollo, Simonetta Lu, Daru Lund, Eiluv Malats, Nuria Mannisto, Satu Le Marchand, Loic Marina, Neyssa Masala, Giovanna Mastrangelo, Giuseppe Matsuo, Keitaro Maynadie, Marc Mckay, James McKean-Cowdin, Roberta Melbye, Mads Melin, Beatrice S. Michaud, Dominique S. Mitsudomi, Tetsuya Monnereau, Alain Montalvan, Rebecca Moore, Lee E. Mortensen, Lotte Maxild Nieters, Alexandra North, Kari E. Novak, Anne J. Oberg, Ann L. Offit, Kenneth Oh, In-Jae Olson, Sara H. Palli, Domenico Pao, William Park, In Kyu Park, Jae Yong Park, Kyong Hwa Patino-Garcia, Ana Pavanello, Sofia Peeters, Petra H. M. Perng, Reury-Perng Peters, Ulrike Petersen, Gloria M. Picci, Piero Pike, Malcolm C. Porru, Stefano Prescott, Jennifer Prokunina-Olsson, Ludmila Qian, Biyun Qiao, You-Lin Rais, Marco Riboli, Elio Riby, Jacques Risch, Harvey A. Rizzato, Cosmeri Rodabough, Rebecca Roman, Eve Roupret, Morgan Ruder, Avima M. de Sanjose, Silvia Scelo, Ghislaine Schned, Alan Schumacher, Fredrick Schwartz, Kendra Schwenn, Molly Scotlandi, Katia Seow, Adeline Serra, Consol Serra, Massimo Sesso, Howard D. Setiawan, Veronica Wendy Severi, Gianluca Severson, Richard K. Shanafelt, Tait D. Shen, Hongbing Shen, Wei Shin, Min-Ho Shiraishi, Kouya Shu, Xiao-Ou Siddiq, Afshan Sierrasesumaga, Luis Sihoe, Alan Dart Loon Skibola, Christine F. Smith, Alex Smith, Martyn T. Southey, Melissa C. Spinelli, John J. Staines, Anthony Stampfer, Meir Stern, Marianna C. Stevens, Victoria L. Stolzenberg-Solomon, Rachael S. Su, Jian Su, Wu-Chou Sund, Malin Sung, Jae Sook Sung, Sook Whan Tan, Wen Tang, Wei Tardon, Adonina Thomas, David Thompson, Carrie A. Tinker, Lesley F. Tirabosco, Roberto Tjonneland, Anne Travis, Ruth C. Trichopoulos, Dimitrios Tsai, Fang-Yu Tsai, Ying-Huang Tucker, Margaret Turner, Jenny Vajdic, Claire M. Vermeulen, Roel C. H. Villano, Danylo J. Vineis, Paolo Virtamo, Jarmo Visvanathan, Kala Wactawski-Wende, Jean Wang, Chaoyu Wang, Chih-Liang Wang, Jiu-Cun Wang, Junwen Wei, Fusheng Weiderpass, Elisabete Weiner, George J. Weinstein, Stephanie Wentzensen, Nicolas White, Emily Witzig, Thomas E. Wolpin, Brian M. Wong, Maria Pik Wu, Chen Wu, Guoping Wu, Junjie Wu, Tangchun Wu, Wei Wu, Xifeng Wu, Yi-Long Wunder, Jay S. Xiang, Yong-Bing Xu, Jun Xu, Ping Yang, Pan-Chyr Yang, Tsung-Ying Ye, Yuanqing Yin, Zhihua Yokota, Jun Yoon, Ho-Il Yu, Chong-Jen Yu, Herbert Yu, Kai Yuan, Jian-Min Zelenetz, Andrew Zeleniuch-Jacquotte, Anne Zhang, Xu-Chao Zhang, Yawei Zhao, Xueying Zhao, Zhenhong Zheng, Hong Zheng, Tongzhang Zheng, Wei Zhou, Baosen Zhu, Meng Zucca, Mariagrazia Boca, Simina M. Cerhan, James R. Ferri, Giovanni M. Hartge, Patricia Hsiung, Chao Agnes Magnani, Corrado Miligi, Lucia Morton, Lindsay M. Smedby, Karin E. Teras, Lauren R. Vijai, Joseph Wang, Sophia S. Brennan, Paul Caporaso, Neil E. Hunter, David J. Kraft, Peter Rothman, Nathaniel Silverman, Debra T. Slager, Susan L. Chanock, Stephen J. Chatterjee, Nilanjan TI Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types SO JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE LA English DT Article ID MULTIPLE SUSCEPTIBILITY LOCI; LUNG-CANCER; FAMILIAL RISK; PANCREATIC-CANCER; SWEDEN; INDIVIDUALS; MUTATIONS; RELATIVES; LYMPHOMA; DATABASE AB Background: Studies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites. Methods: Between 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers. Results: GWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, h(l)(2), on the liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the combined heritability of multiple smoking characteristics, we calculate that at least 24% (95% confidence interval [CI] = 14% to 37%) and 7% (95% CI = 4% to 11%) of the heritability for lung and bladder cancer, respectively, can be attributed to genetic determinants of smoking. Most pairs of cancers studied did not show evidence of strong genetic correlation. We found only four pairs of cancers with marginally statistically significant correlations, specifically kidney and testes (rho = 0.73, SE = 0.28), diffuse large B-cell lymphoma (DLBCL) and pediatric osteosarcoma (rho = 0.53, SE = 0.21), DLBCL and chronic lymphocytic leukemia (CLL) (rho = 0.51, SE = 0.18), and bladder and lung (rho = 0.35, SE = 0.14). Correlation analysis also indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the genetic etiology for the same disease can vary by population and environmental exposures. Conclusion: Our results provide important insights into the genetic architecture of cancers and suggest new avenues for investigation. C1 [Sampson, Joshua N.; Panagiotou, Orestis; Berndt, Sonja I.; Lan, Qing; Abnet, Christian C.; Amundadottir, Laufey T.; Mirabello, Lisa; Savage, Sharon A.; Taylor, Philip R.; McGlynn, Katherine A.; Rajaraman, Preetha; Albanes, Demetrius; Bassig, Bryan A.; Black, Amanda; Brinton, Louise; Chow, Wong-Ho; Chung, Charles C.; Colt, Joanne S.; Fraumeni, Joseph F., Jr.; Freedman, Neal D.; Freeman, Laura E. Beane; Garcia-Closas, Montserrat; Goldstein, Alisa M.; Hoover, Robert N.; Hu, Nan; Hu, Wei; Inskip, Peter D.; Ji, Bu-Tian; Kitahara, Cari M.; Liao, Linda M.; Linet, Martha S.; Moore, Lee E.; Prokunina-Olsson, Ludmila; Stolzenberg-Solomon, Rachael S.; Tang, Wei; Tucker, Margaret; Wang, Chaoyu; Weinstein, Stephanie; Wentzensen, Nicolas; Yu, Kai; Hartge, Patricia; Caporaso, Neil E.; Rothman, Nathaniel; Silverman, Debra T.; Chanock, Stephen J.; Chatterjee, Nilanjan] NCI, Div Canc Epidemiol & Genet, Bethesda, MD USA. [Wheeler, William A.; Giffen, Carol] Informat Management Serv Inc, Silver Spring, MD USA. [Yeager, Meredith; Wang, Zhaoming; Burdett, Laurie; Hutchinson, Amy; Liu, Chenwei] Natl Canc Inst, Div Canc Epidemiol & Genet, Canc Genom Res Lab, Gaithersburg, MD USA. [De Vivo, Immaculata; Bertrand, Kimberly A.; Birmann, Brenda M.; Chen, Constance; Crous-Bou, Marta; Fuchs, Charles; Giovannucci, Edward; Lindstrom, Sara; Prescott, Jennifer; Stampfer, Meir; Hunter, David J.] Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA. [De Vivo, Immaculata; Bertrand, Kimberly A.; Birmann, Brenda M.; Chen, Constance; Crous-Bou, Marta; Fuchs, Charles; Giovannucci, Edward; Lindstrom, Sara; Prescott, Jennifer; Stampfer, Meir; Hunter, David J.] Harvard Univ, Sch Med, Boston, MA 02115 USA. [De Vivo, Immaculata; Bertrand, Kimberly A.; Chen, Constance; Crous-Bou, Marta; Giovannucci, Edward; Kelly, Rachel S.; Lindstrom, Sara; Prescott, Jennifer; Sesso, Howard D.; Stampfer, Meir; Trichopoulos, Dimitrios; Hunter, David J.; Kraft, Peter] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. [Purdue, Mark P.] Ontario Hlth Study, Toronto, ON, Canada. [Adami, Hans-Olov; Weiderpass, Elisabete] Karolinska Inst, Dept Med Epidemiol & Biostatist, Stockholm, Sweden. [Ahlbom, Anders; Feychting, Maria] Karolinska Inst, Inst Environm Med, Dept Epidemiol, S-10401 Stockholm, Sweden. [Amary, Maria Fernanda; Flanagan, Adrienne M.; Halai, Dina] UCL Canc Inst, London, England. [Amary, Maria Fernanda; Flanagan, Adrienne M.; Halai, Dina; Tirabosco, Roberto] Royal Natl Orthopaed Hosp NHS Trust, Middlesbrough, Cleveland, England. [An, She-Juan; Su, Jian; Wu, Yi-Long; Zhang, Xu-Chao] Guangdong Acad Med Sci, Guangdong Gen Hosp, Guangdong Prov Key Lab Translat Med Lung Canc, Guangdong Lung Canc Inst, Guangzhou, Guangdong, Peoples R China. [Andersson, Ulrika; Henriksson, Roger; Melin, Beatrice S.] Umea Univ, Dept Radiat Sci Oncol, Umea, Sweden. [Andriole, Gerald, Jr.; Grubb, Robert, III] Washington Univ, Sch Med, Div Urol Surg, St Louis, MO 63110 USA. [Andrulis, Irene L.; Gokgoz, Nalan; Wunder, Jay S.] Univ Toronto, Litwin Ctr Canc Genet, Toronto, ON, Canada. [Andrulis, Irene L.; Gallinger, Steven; Gokgoz, Nalan; Wunder, Jay S.] Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON M5G 1X5, Canada. [Angelucci, Emanuele] Osped Oncol Riferimento Regionale Businco, Hematol Unit, Cagliari, Italy. [Ansell, Stephen M.; Habermann, Thomas M.; Liebow, Mark; Novak, Anne J.; Shanafelt, Tait D.; Thompson, Carrie A.; Witzig, Thomas E.] Mayo Clin, Dept Med, Rochester, MN USA. [Arici, Cecilia; Carta, Angela; Porru, Stefano] Univ Brescia, Dept Med & Surg Specialties, Radiol Sci & Publ Hlth, Brescia, Italy. [Armstrong, Bruce K.; Kricker, Anne] Univ Sydney, Sydney Sch Publ Hlth, Sydney, NSW 2006, Australia. [Arslan, Alan A.] NYU, Sch Med, Dept Obstet & Gynecol, New York, NY USA. [Arslan, Alan A.; Zelenetz, Andrew] NYU, Sch Med, Dept Environm Med, New York, NY USA. [Arslan, Alan A.; Zelenetz, Andrew] NYU, Sch Med, Dept Populat Hlth, New York, NY USA. [Arslan, Alan A.; Zelenetz, Andrew] NYU Langone, Med Ctr, Perlmutter Canc Ctr, New York, NY USA. [Austin, Melissa A.; White, Emily] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA. [Barkauskas, Donald A.; Van Den Berg, David; Conti, David; Cortessis, Victoria K.; Cozen, Wendy; Henderson, Brian; McKean-Cowdin, Roberta; Schumacher, Fredrick; Setiawan, Veronica Wendy] Univ So Calif, Dept Prevent Med, USC Keck Sch Med, Los Angeles, CA 90089 USA. [Bassig, Bryan A.; Zhang, Yawei; Zheng, Tongzhang] Yale Sch Publ Hlth, Dept Environm Hlth Sci, New Haven, CT USA. German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Baden Wurttembe, Germany. [Benavente, Yolanda; de Sanjose, Silvia] Inst Catala Oncol, IDIBELL, Unit Infect & Canc UNIC, Canc Epidemiol Res Programme, Barcelona, Spain. [Benavente, Yolanda; Chirlaque, Maria-Dolores; Dorronsoro, Miren; Lloreta, Josep; Tardon, Adonina] Ctr Invest Biomed Red Epidemiol Salud Publ CIBERE, Madrid, Spain. [Benhamou, Simone] Fdn Jean Dausset Ctr Etude Polymorphisme Humain C, Inst Natl sante & Rech med, U946, Paris, France. [Benhamou, Simone] Ctr Natl Receherche Sci, Inst Gustave Roussy, UMR8200, Villejuif, France. [Berg, Christine] Natl Canc Inst, Canc Prevent Div, Early Detect Res Grp, Bethesda, MD USA. [Van Den Berg, David; Conti, David; Cortessis, Victoria K.; Cozen, Wendy] Univ So Calif, Norris Comprehens Canc Ctr, USC Keck Sch Med, Los Angeles, CA USA. [Bernstein, Leslie; Wang, Sophia S.] Beckman Res Inst City Hope, Dept Canc Etiol, Duarte, CA USA. [Boeing, Heiner] German Inst Human Nutr, Dept Epidemiol, Potsdam, Germany. [Boffetta, Paolo] Tisch Canc Inst, Icahn Sch Med Mt Sinai, New York, NY USA. [Clavel-Chapelon, Franoise; Dossus, Laure] Ctr Res Epidemiol & Populat Hlth CESP, INSERM, Nutr,Hormones & Womens Hlth team, U1018, F-94805 Villejuif, France. [Boutron-Ruault, Marie-Christine; Clavel, Jacqueline; Clavel-Chapelon, Franoise; Dossus, Laure; Monnereau, Alain] Univ Paris 11, F-94805 Villejuif, France. [Boutron-Ruault, Marie-Christine; Clavel-Chapelon, Franoise; Dossus, Laure] Inst Gustave Roussy, F-94805 Villejuif, France. [Bracci, Paige M.; Holly, Elizabeth A.] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA. [Brooks-Wilson, Angela R.] BC Canc Agcy, Genome Sci Ctr, Vancouver, BC, Canada. [Brooks-Wilson, Angela R.] Simon Fraser Univ, Dept Biomed Physiol & Kinesiol, Burnaby, BC V5A 1S6, Canada. [Bueno-de-Mesquita, H. Bas] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands. [Bueno-de-Mesquita, H. Bas] Univ Med Ctr Utrecht, Dept Gastroenterol & Hepatol, Utrecht, Netherlands. [Buring, Julie; Gaziano, J. Michael; Sesso, Howard D.] Brigham & Womens Hosp, Dept Med, Div Prevent Med, Boston, MA 02115 USA. [Buring, Julie; Gaziano, J. Michael; Sesso, Howard D.] Harvard Univ, Sch Med, Boston, MA USA. [Buring, Julie; Gaziano, J. Michael; Sesso, Howard D.] Brigham & Womens Hosp, Dept Med, Div Aging, Boston, MD 02115 USA. [Buring, Julie; Gaziano, J. Michael; Sesso, Howard D.] Harvard Univ, Sch Med, Boston, MD USA. [Butler, Mary Ann; Carreon, Tania; Ruder, Avima M.] NIOSH, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. [Cai, Qiuyin; Shu, Xiao-Ou; Zheng, Wei] Vanderbilt Univ, Ctr Med, Dept Med, Nashville, TN 37232 USA. [Cai, Qiuyin; Shu, Xiao-Ou; Zheng, Wei] Vanderbilt Univ, Med Ctr, Vanderbilt Ingram Canc Ctr, Nashville, TN USA. [Cancel-Tassin, Geraldine; Comperat, Eva; Cussenot, Olivier; Roupret, Morgan] Ctr Rech Pathol Prostat, Paris, France. [Cancel-Tassin, Geraldine; Comperat, Eva; Cussenot, Olivier; Roupret, Morgan] Univ Paris 06, ONCOTYPE URO, GRC 5, Paris, France. [Canzian, Federico; Rizzato, Cosmeri] German Canc Res Ctr, Genom Epidemiol Grp, Heidelberg, Germany. [Carrato, Alfredo] Ramon y Cajal Univ Hosp, Madrid, Spain. [Chan, John K. C.] Queen Elizabeth Hosp, Dept Pathol, Hong Kong, Hong Kong, Peoples R China. [Chang, Ellen T.] Stanford Univ, Sch Med, Div Epidemiol, Dept Hlth Res & Policy, Stanford, CA 94305 USA. [Chang, Ellen T.] Exponent Inc, Ctr Epidemiol & Computat Biol, Hlth Sci, Menlo Pk, CA USA. [Chang, Gee-Chen] Natl Yang Ming Univ, Sch Med, Dept Med, Taipei 112, Taiwan. [Chang, Gee-Chen; Chen, Kun-Chieh; Yang, Tsung-Ying] Taichung Vet Gen Hosp, Div Chest Med, Dept Internal Med, Taichung, Taiwan. [Chang, I-Shou; Chen, Chung-Hsing; Tsai, Fang-Yu] Natl Hlth Res Inst, Natl Inst Canc Res, Zhunan, Taiwan. [Chang, Jiang; Lin, Dongxin; Tan, Wen; Wu, Chen] Chinese Acad Med Sci, Canc Inst & Hosp, Dept Etiol & Carcinogenesis, Beijing 100730, Peoples R China. [Chang, Jiang; Lin, Dongxin; Tan, Wen; Wu, Chen] Peking Union Med Coll, Beijing 100021, Peoples R China. [Chen, Chien-Jen; Li, Yao-Jen] Genom Res Ctr, Taipei, Taiwan. [Chen, Chih-Yi] Chung Shan Med Univ, Chung Shan Med Univ Hosp, Dept Surg, Div Thorac Surg,Inst Med, Taichung, Taiwan. [Chen, Chu; Hohensee, Chancellor] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USA. [Chen, Chu; Giovannucci, Edward; Stampfer, Meir; Hunter, David J.] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA. [Chen, Hongyan; Jin, Li; Lu, Daru; Wang, Jiu-Cun; Wu, Junjie; Zhao, Xueying; Zhao, Zhenhong] Fudan Univ, Sch Life Sci, Minist Educ, Key Lab Contemporary Anthropol, Shanghai 200433, Peoples R China. [Chen, Kexin; Li, Haixin; Zheng, Hong] Med Univ, Canc Inst & Hosp, Natl Clin Res Ctr Canc, Key Lab Canc Prevent & Therapy,Dept Epidemiol & B, Tianjin, Peoples R China. [Chen, Kuan-Yu; Yu, Chong-Jen] Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan. [Chen, Ying; Lim, Wei-Yen; Seow, Adeline] Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore 117548, Singapore. [Chen, Ying-Hsiang; Chen, Yi-Song; Chien, Li-Hsin; Hsiao, Chin-Fu] Natl Hlth Res Inst, Inst Populat Hlth Sci, Zhunan, Taiwan. [Chen, Yuh-Min; Perng, Reury-Perng] Taipei Vet Gen Hosp, Dept Chest Med, Taipei, Taiwan. [Chen, Yuh-Min] Taipei Med Univ, Taipei Canc Ctr, Taipei, Taiwan. [Chirlaque, Maria-Dolores; Huerta, Jose-Maria] IMIB Arrixaca, Dept Epidemiol, Murcia Reg Hlth Author, Murcia, Spain. [Choi, Jin Eun; Choi, Yi Young] Kyungpook Natl Univ, Med Ctr, Canc Res Ctr, Daegu, South Korea. [Clavel, Jacqueline; Monnereau, Alain] INSERM, Ctr Res Epidemiol & Populat Hlth CESP, U1018, Environm Epidemiol Canc Grp, Villejuif, France. [Cocco, Pierluigi; Rais, Marco] Univ Cagliari, Dept Publ Hlth Clin & Mol Med, Cagliari, Italy. [Comperat, Eva; Roupret, Morgan] AP HP, Pitie Salpetriere, Dept Urol, Paris, France. [Comperat, Eva] AP HP, Pitie Salpetriere, Dept Pathol, Paris, France. [Conde, Lucia; Riby, Jacques; Skibola, Christine F.] Univ Alabama Birmingham, Sch Publ Hlth, Dept Epidemiol, Birmingham, AL 35294 USA. [Conde, Lucia; Riby, Jacques; Skibola, Christine F.] Univ Alabama Birmingham, Ctr Comprehens Canc, Birmingham, AL 35294 USA. [Conde, Lucia; Riby, Jacques; Skibola, Christine F.; Smith, Martyn T.] Univ Calif Berkeley, Sch Publ Hlth, Div Environm Hlth Sci, Berkeley, CA 94720 USA. [Conde, Lucia; Riby, Jacques; Skibola, Christine F.; Smith, Martyn T.] BC Canc Agcy, Ctr Lymphoid Canc, Vancouver, BC, Canada. [Connors, Joseph M.] Univ British Columbia, Dept Med, Vancouver, BC, Canada. [Cortessis, Victoria K.] Univ So Calif, Dept Obstet & Gynecol, Los Angeles, CA 90089 USA. [Cotterchio, Michelle] Canc Care Ontario, Toronto, ON, Canada. [Cotterchio, Michelle] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada. [Crouch, Simon; Kane, Eleanor; Lightfoot, Tracy; Riboli, Elio; Smith, Alex] Univ York, Dept Hlth Sci, York YO10 5DD, N Yorkshire, England. [Cussenot, Olivier] Hop Tenon, AP HP, Dept Urol, F-75970 Paris, France. [Davis, Faith G.] Univ Alberta, Sch Publ Hlth, Edmonton, AB, Canada. [Ding, Ti] Shanxi Canc Hosp, Taiyuan, Shanxi, Peoples R China. [Diver, W. Ryan; Gapstur, Susan M.; Gaudet, Mia M.; Jacobs, Eric J.; Stevens, Victoria L.] Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA. [Dorronsoro, Miren] BioDonostia Res Inst, Dept Hlth, Basque Region, Spain. [Duell, Eric J.] Bellvitge Biomed Res Inst IDIBELL, Catalan Inst Oncol ICO, Canc Epidemiol Res Program, Unit Nutr Environm & Canc, Barcelona, Spain. [Ennas, Maria Grazia] Univ Cagliari, Dept Biomed Sci, Cagliari, Italy. [Erickson, Ralph L.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Foretova, Lenka] Masaryk Mem Canc Inst, Dept Canc Epidemiol & Genet, Brno, Czech Republic. [Foretova, Lenka] MF MU, Brno, Czech Republic. [Fuchs, Charles; Wolpin, Brian M.] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. [Gago-Dominguez, Manuela] Inst Invest Sanitaria de Santiago, Serv Galego Saude SERGAS, Galician Fdn Genom Med, Genom Med Grp, Santiago De Compostela, Spain. [Gao, Yu-Tang] Shanghai Canc Inst, Dept Epidemiol, Shanghai, Peoples R China. [Garcia-Closas, Montserrat] Inst Canc Res, Div Genet & Epidemiol, London, England. [Garcia-Closas, Reina] Hosp Univ Canarias, Unidad Invest, San Cristobal la Laguna, Spain. [Gascoyne, Randy D.] Univ British Columbia, Dept Pathol, Vancouver, BC, Canada. [Gastier-Foster, Julie] Nationwide Childrens Hosp, Columbus, OH USA. [Gastier-Foster, Julie] Ohio State Univ, Dept Pathol & Pediat, Columbus, OH 43210 USA. [Gaziano, J. Michael] Vet Affairs Boston Healthcare Syst, Geriatr Res Educ & Clin Ctr, Massachusetts Vet Epidemiol Res & Informat Ctr, Boston, MA USA. [Giles, Graham G.; Severi, Gianluca] Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia. [Giles, Graham G.; Severi, Gianluca] Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Biostat & Epidemiol, Carlton, Vic 3053, Australia. [Glimelius, Bengt] Karolinska Inst, Dept Pathol & Oncol, Stockholm, Sweden. [Glimelius, Bengt] Uppsala Univ, Dept Radiol Oncol & Radiat Sci, Uppsala, Sweden. [Goggins, Michael] Sidney Kimmel Canc Ctr, Dept Oncol, Baltimore, MD USA. [Goggins, Michael] Johns Hopkins Univ, Baltimore, MD USA. [Goggins, Michael] Sidney Kimmel Canc Ctr, Dept Pathol, Baltimore, MD USA. [Goggins, Michael] Sidney Kimmel Canc Ctr, Dept Med, Baltimore, MD USA. [Gorlick, Richard] Childrens Hosp Montefiore, Albert Einstein Coll Med, Bronx, NY USA. [Gross, Myron] Univ Minnesota, Lab Med & Pathol, Minneapolis, MN USA. [Gu, Jian; Wu, Xifeng; Ye, Yuanqing] Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA. [Guan, Peng; He, Qincheng; Wactawski-Wende, Jean; Yin, Zhihua; Zhou, Baosen] China Med Univ, Sch Publ Hlth, Dept Epidemiol, Shenyang 110001, Peoples R China. [Gunter, Marc; Peeters, Petra H. M.] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England. [Guo, Huan; Wu, Tangchun] Huazhong Univ Sci & Technol, Sch Publ Hlth, Inst Occupat Med, Wuhan 430074, Peoples R China. [Guo, Huan; Wu, Tangchun] Huazhong Univ Sci & Technol, Sch Publ Hlth, Minist Educ, Key Lab Environm & Hlth, Wuhan 430074, Peoples R China. [Hallmans, Goran] Umea Univ, Dept Publ Hlth & Clin Med, Nutr Res, Umea, Sweden. [Hassan, Manal; Li, Donghui] Univ Texas MD Anderson Canc Ctr, Dept Gastrointestinal Med Oncol, Houston, TX USA. [Picci, Piero; Schwartz, Kendra; Serra, Massimo] Orthopaed Rizzoli Inst, Expt Oncol Lab, Bologna, Italy. [He, Xingzhou] Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China. [Helzlsouer, Kathy; Hoffman-Bolton, Judith; Klein, Alison P.; Visvanathan, Kala] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA. [Hjalgrim, Henrik; Melbye, Mads] Statens Serum Inst, Dept Epidemiol Res, Div Hlth Surveillance & Res, DK-2300 Copenhagen, Denmark. [Holford, Theodore R.] Yale Univ, Sch Publ Hlth, Dept Biostat, New Haven, CT USA. [Hong, Yun-Chul] Seoul Natl Univ, Coll Med, Dept Prevent Med, Seoul, South Korea. [Horn-Ross, Pamela L.] Canc Prevent Inst Calif, Fremont, CA USA. [Hosain, G. M. Monawar] New Hampshire State Canc Registry, Concord, NH USA. [Hosgood, H. Dean, III] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA. [Hsiao, Chin-Fu] Natl Hlth Res Inst, Taiwan Lung Canc Tissue Specimen Informat Resourc, Zhunan, Taiwan. [Hu, Zhibin; Jin, Guangfu; Shen, Hongbing; Shen, Wei] Nanjing Med Univ, Jiangsu Collaborat Innovat Ctr Canc Personalized, Nanjing, Jiangsu, Peoples R China. [Hu, Zhibin; Jin, Guangfu; Shen, Hongbing; Shen, Wei] Nanjing Med Univ, Sch Publ Hlth, Ctr Canc, Jiangsu Key Lab Canc Biomarkers Prevent & Treatme, Nanjing, Jiangsu, Peoples R China. [Huang, Ming-Shyan; Hung, Jen-Yu] Kaohsiung Med Univ, Sch Med, Kaohsiung Med Univ Hosp, Dept Internal Med, Kaohsiung, Taiwan. [Jackson, Rebecca D.] Ohio State Univ, Div Endocrinol Diabet & Metab, Columbus, OH 43210 USA. [Jenab, Mazda; Mckay, James; Scelo, Ghislaine; Brennan, Paul] Int Agcy Res Canc, F-69372 Lyon, France. [Jeon, Hyo-Sung] Kyungpook Natl Univ, Mol Diagnost & Imaging Ctr, Daegu, South Korea. [Johansen, Christoffer] Danish Canc Soc Res Ctr, Unit Survivorship, Copenhagen, Denmark. [Johnson, Alison] Vermont Canc Registry, Burlington, VT USA. [Jung, Yoo Jin; Kang, Chang Hyun; Kim, Young Tae; Park, In Kyu] Seoul Natl Univ, Coll Med, Canc Res Inst, Dept Thorac & Cardiovasc Surg, Seoul, South Korea. [Kamineni, Aruna] Grp Hlth Res Inst, Seattle, WA USA. [Karagas, Margaret R.; Schned, Alan] Dartmouth Coll, Geisel Sch Med, Hanover, NH 03755 USA. [Kelly, Rachel S.; Vineis, Paolo] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, MRC PHE Ctr Environm & Hlth, London, England. [Khaw, Kay-Tee] Univ Cambridge, Cambridge CB2 1TN, England. [Kim, Hee Nam] Chonnam Natl Univ, Ctr Creat Biomed Scientists, Gwangju, South Korea. [Kim, Jin Hee] Seoul Natl Univ, Grad Sch Publ Hlth, Dept Environm Hlth, Seoul, South Korea. [Kim, Jun Suk] Korea Univ, Guro Hosp, Coll Med, Dept Internal Med,Div Med Oncol, Seoul, South Korea. [Kim, Yeul Hong; Park, Kyong Hwa] Korea Univ, Coll Med, Anam Hosp, Div Hematol Oncol,Dept Internal Med, Seoul 136705, South Korea. [Kim, Young-Chul; Oh, In-Jae] Chonnam Natl Univ, Hwasun Hosp, Lung & Esophageal Canc Clin, Hwasun Eup, South Korea. [Kim, Young-Chul; Oh, In-Jae] Chonnam Natl Univ, Sch Med, Dept Internal Med, Gwangju, South Korea. [Klein, Alison P.] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA. [Klein, Robert J.] Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, Icahn Inst Genom & Multiscale Biol, New York, NY 10029 USA. [Kogevinas, Manolis] Ctr Res Environm Epidemiol CREAL, Barcelona, Spain. [Kogevinas, Manolis] Hosp del Mar, Municipal Inst Med Res IMIM, Barcelona, Spain. [Kogevinas, Manolis] Natl Sch Publ Hlth, Athens, Greece. [Kohno, Takashi] Natl Canc Ctr, Res Inst, Div Genome Biol, Tokyo 104, Japan. [Kolonel, Laurence N.] Canc Res Ctr Hawaii, Honolulu, HI USA. [Krogh, Vittorio] Fdn IRCCS Ist Nazl Tumori, Epidemiol & Prevent Unit, Milan, Italy. [Kunitoh, Hideo] Japanese Red Cross Med Ctr, Dept Med Oncol, Tokyo, Japan. [Kurtz, Robert C.; Offit, Kenneth; Villano, Danylo J.; Virtamo, Jarmo; Zelenetz, Andrew] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10021 USA. [Kweon, Sun-Seog] Chonnam Natl Univ, Hwasun Hosp, Jeonnam Reg Canc Ctr, Hwasun Eup, South Korea. [Kweon, Sun-Seog; Shin, Min-Ho] Chonnam Natl Univ, Sch Med, Dept Prevent Med, Gwangju, South Korea. [Lawrence, Charles; Montalvan, Rebecca] Westat Corp, Rockville, MD USA. [Lecanda, Fernando; Patino-Garcia, Ana; Sierrasesumaga, Luis] Univ Navarra, Univ Navarra Clin, Dept Pediat, Pamplona, Spain. [Lee, Victor Ho Fun] Univ Hong Kong, Dept Clin Oncol, Hong Kong, Hong Kong, Peoples R China. [Liu, Jianjun] Qujing Ctr Dis Control & Prevent, Sanjiangdadao, Qujing, Peoples R China. [Li, Yuqing] Canc Prevent Inst Calif, Fremont, CA USA. [Lin, Chien-Chung] Natl Cheng Kung Univ, Cheng Kung Univ Med Coll & Hosp, Dept Internal Med, Tainan 701, Taiwan. [Weiner, George J.] Univ Iowa, Carver Coll Med, Dept Internal Med, Iowa City, IA USA. [Liu, Jianjun] Genome Inst Singapore, Human Genet, Singapore, Singapore. [Liu, Li] Huazhong Univ Sci & Technol, Ctr Canc, Union Hosp, Wuhan 430074, Peoples R China. Umea Univ, Dept Surg & Perioperat Sci Urol & Androl, Umea, Sweden. Univ Florence, Dept Surg & Translat Med, Sect Anatomopathol, Florence, Italy. [Lund, Eiluv; Weiderpass, Elisabete] Univ Tromso, Arctic Univ Norway, Fac Hlth Sci, Dept Community Med, Tromso, Norway. Spanish Natl Canc Res Ctr CNIO, Genet & Mol Epidemiol Grp, Madrid, Spain. [Mannisto, Satu; Virtamo, Jarmo] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland. [Le Marchand, Loic; Yu, Herbert] Univ Hawaii, Ctr Canc, Canc Epidemiol Program, Honolulu, HI 96822 USA. Stanford Univ, Lucile Packard Childrens Hosp, Palo Alto, CA 94304 USA. [Masala, Giovanna; Palli, Domenico] Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy. [Mastrangelo, Giuseppe; Pavanello, Sofia] Univ Padua, Dept Cardiac Thorac & Vasc Sci, Padua, Italy. [Matsuo, Keitaro] Aichi Canc Res Inst, Div Mol Med, Nagoya, Aichi, Japan. [Maynadie, Marc] Univ Burgundy, Registre Hemopathies Malignes Cote dOr, EA 4184, Dijon, France. [Maynadie, Marc] Dijon Univ Hosp, Dijon, France. [Melbye, Mads] Stanford Univ, Dept Med, Sch Med, Stanford, CA 94305 USA. Brown Univ, Dept Epidemiol, Div Biol & Med, Providence, RI 02912 USA. [Riboli, Elio; Siddiq, Afshan] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, London, England. [Mitsudomi, Tetsuya] Kinki Univ, Sch Med, Div Thorac Surg, Sayama, Osaka 589, Japan. [Monnereau, Alain] Inst Bergonie, Registre Hemopathies Malignes Gironde, Bordeaux, France. Aarhus Univ, Epidemiol Sect, DK-8000 Aarhus C, Denmark. Aalborg Univ Hosp, Dept Cardiol, Aalborg, Denmark. [Nieters, Alexandra] Univ Med Ctr Freiburg, Ctr Chron Immunodeficiency, Freiburg, Baden Wurttembe, Germany. [North, Kari E.] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA. [North, Kari E.] Univ N Carolina, Carolina Ctr Genome Sci, Chapel Hill, NC USA. [Oberg, Ann L.] Mayo Clin, Dept Hlth Sci Res, Div Biomed Stat & Informat, Rochester, MN USA. [Olson, Sara H.; Pike, Malcolm C.] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA. [Pao, William] Vanderbilt Univ, Med Ctr, Div Hematol & Oncol, Nashville, TN 37235 USA. [Park, Jae Yong] Kyungpook Natl Univ, Med Ctr, Lung Canc Ctr, Daegu, South Korea. [Peeters, Petra H. M.; Vermeulen, Roel C. H.] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care 194, Utrecht, Netherlands. [Peeters, Petra H. M.] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Primary Care & Publ Hlth, London, England. [Petersen, Gloria M.] Mayo Clin, Div Epidemiol, Dept Hlth Sci Res, Rochester, MN USA. [Qian, Biyun] Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan. [Qiao, You-Lin] Chinese Acad Med Sci, Canc Inst & Hosp, Dept Epidemiol, Beijing 100730, Peoples R China. [Risch, Harvey A.] Yale Univ, Sch Publ Hlth, Dept Chron Dis Epidemiol, New Haven, CT USA. [Severson, Richard K.] Wayne State Univ, Dept Family Med & Publ Hlth Sci, Detroit, MI USA. Karmanos Canc Inst, Detroit, MI USA. [Schwenn, Molly] Maine Canc Registry, Augusta, ME USA. [Serra, Consol] Univ Pompeu Fabra, Dept Ciencies Experimentals & Salut, Barcelona, Spain. [Severi, Gianluca; Vineis, Paolo] Human Genet Fdn, Turin, Italy. [Sihoe, Alan Dart Loon] Queen Mary Hosp, Div Cardiothorac Surg, Dept Surg, Hong Kong, Hong Kong, Peoples R China. Univ Melbourne, Dept Pathol, Parkville, Vic 3052, Australia. [Spinelli, John J.] BC Canc Agcy, Canc Control Res, Vancouver, BC, Canada. [Spinelli, John J.] Univ British Columbia, Sch Populat & Publ Hlth, Vancouver, BC V5Z 1M9, Canada. [Staines, Anthony] Dublin City Univ, Sch Nursing & Human Sci, Dublin 9, Ireland. [Su, Wu-Chou] Natl Cheng Kung Univ, Med Coll & Hosp, Tainan 701, Taiwan. [Sund, Malin] Umea Univ, Dept Surg & Perioperat Sci, Surg, Umea, Sweden. [Sung, Jae Sook] Korea Univ, Canc Res Inst, Seoul, South Korea. [Sung, Sook Whan] Seoul St Marys Hosp, Dept Thorac & Cardiovasc Surg, Seoul, South Korea. [Tardon, Adonina] Univ Oviedo, Inst Univ Oncol, Oviedo, Spain. [Thomas, David] St Vincents Hosp, Garvan Inst Med Res, Kinghorn Canc Ctr, Darlinghurst, NSW 2010, Australia. [Tjonneland, Anne] Danish Canc Soc, Res Ctr, Copenhagen, Denmark. [Travis, Ruth C.] Univ Oxford, Canc Epidemiol Unit, Oxford, England. [Trichopoulos, Dimitrios] Acad Athens, Bur Epidemiol Res, Athens, Greece. [Trichopoulos, Dimitrios] Hellen Hlth Fdn, Athens, Greece. [Tsai, Ying-Huang] Chang Gung Mem Hosp, Dept Resp Thearpy, Chiayi, Taiwan. [Turner, Jenny] Macquarie Univ, Australian Sch Adv Med, Sydney, NSW 2109, Australia. [Turner, Jenny] Douglass Hanly Moir Pathol, Dept Histopathol, Macquarie Pk, NSW, Australia. [Vajdic, Claire M.] Univ New S Wales, Prince Wales Clin Sch, Sydney, NSW, Australia. [Vermeulen, Roel C. H.] Univ Utrecht, Inst Risk Assessment Sci, Utrecht, Netherlands. [Wactawski-Wende, Jean] SUNY Buffalo, Dept Social & Prevent Med, Buffalo, NY 14260 USA. [Wang, Chih-Liang] Chang Gung Mem Hosp, Dept Pulm & Crit Care, Taoyuan, Taiwan. [Wang, Jiu-Cun] Fudan Univ, Sch Life Sci, State Key Lab Genet Engn, Shanghai, Peoples R China. [Wang, Junwen] Univ Hong Kong, Li Ka Shing Fac Med, Ctr Genom Sci, Hong Kong, Peoples R China. [Wang, Junwen] Univ Hong Kong, Li Ka Shing Fac Med, Dept Biochem, Hong Kong, Hong Kong, Peoples R China. [Wei, Fusheng; Wu, Guoping] China Natl Environm Monitoring Ctr, Beijing, Peoples R China. [Weiderpass, Elisabete] Canc Registry Norway, Oslo, Norway. [Weiderpass, Elisabete] Folkhalsan Res Ctr, Dept Genet Epidemiol, Helsinki, Finland. [Wolpin, Brian M.] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA. [Wolpin, Brian M.] Harvard Univ, Sch Med, Boston, MA USA. [Wong, Maria Pik] Univ Hong Kong, Li Ka Shing Fac Med, Dept Pathol, Hong Kong, Hong Kong, Peoples R China. [Wu, Chen] Chinese Acad Med Sci, Canc Inst & Hosp, State Key Lab Mol Oncol, Beijing 100730, Peoples R China. [Wu, Chen] Peking Union Med Coll, Beijing 100021, Peoples R China. [Xiang, Yong-Bing] Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Shanghai Canc Inst, Shanghai 200030, Peoples R China. [Xu, Jun] Univ Hong Kong, Sch Publ Hlth, Hong Kong, Hong Kong, Peoples R China. [Xu, Ping] Wuhan Iron & Steel Corp Staff Worker Hosp, Dept Oncol, Wuhan, Peoples R China. [Yang, Pan-Chyr] Natl Taiwan Univ, Coll Med, Dept Internal Med, Taipei, Taiwan. [Yokota, Jun] Inst Predict & Personalized Med Canc IMPPC, Barcelona, Spain. [Yoon, Ho-Il] Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Songnam, South Korea. [Yuan, Jian-Min] Univ Pittsburgh, Inst Canc, Pittsburgh, PA USA. Georgetown Univ, Med Ctr, Innovat Ctr Biomed Informat, Washington, DC USA. Georgetown Univ, Med Ctr, Dept Oncol, Washington, DC 20007 USA. [Cerhan, James R.; Slager, Susan L.] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA. [Ferri, Giovanni M.] Univ Bari, Interdisciplinary Dept Med, Bari, Italy. [Magnani, Corrado] Univ Piemonte Orientale, Dept Translat Med, CPO Piemonte & Unit Med Stat & Epidemiol, Novara, Italy. [Mirabello, Lisa] Canc Prevent & Res Inst ISPO, Environm & Occupat Epidemiol Unit, Florence, Italy. [Smedby, Karin E.] Karolinska Univ Hosp, Karolinska Inst, Dept Med, Stockholm, Sweden. [Hunter, David J.] Broad Inst Harvard, Cambridge, MA USA. [Hunter, David J.] MIT, Cambridge, MA 02139 USA. [Kraft, Peter] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA. RP Sampson, JN (reprint author), NCI, Biostat Branch, Div Canc Epidemiol & Genet, 9609 Med Ctr Dr,7E594, Rockville, MD 20815 USA. EM joshua.sampson@nih.gov; nilanjan.chatterjee@nih.gov RI Wang, Junwen/D-3700-2011; Qiao, You-Lin/B-4139-2012; Clavel, Jacqueline/Q-2750-2016; Hattinger, Claudia/Q-1212-2016; Beane Freeman, Laura/C-4468-2015; Kitahara, Cari/R-8267-2016; Jung, Yoojin/G-2519-2015; Kogevinas, Manolis/C-3918-2017; Weiderpass, Elisabete/M-4029-2016; Brooks-Wilson, Angela/E-9399-2012; Abnet, Christian/C-4111-2015; Purdue, Mark/C-9228-2016; Jin, Li/C-1468-2009; Savage, Sharon/B-9747-2015; de Sanjose Llongueras, Silvia/H-6339-2014; Andrulis, Irene/E-7267-2013; Gallinger, Steven/E-4575-2013; Benhamou, Simone/K-6554-2015; Krogh, Vittorio/K-2628-2016 OI Wang, Junwen/0000-0002-4432-4707; Qiao, You-Lin/0000-0001-6380-0871; Clavel, Jacqueline/0000-0002-3616-7676; Hattinger, Claudia/0000-0002-9316-5095; Beane Freeman, Laura/0000-0003-1294-4124; Joseph, Vijai/0000-0002-7933-151X; Weiderpass, Elisabete/0000-0003-2237-0128; Brooks-Wilson, Angela/0000-0003-1009-6408; Abnet, Christian/0000-0002-3008-7843; Purdue, Mark/0000-0003-1177-3108; Jin, Li/0000-0002-4546-2415; Savage, Sharon/0000-0001-6006-0740; Krogh, Vittorio/0000-0003-0122-8624 FU Intramural Research Program of the National Institutes of Health FX This study was supported by the Intramural Research Program of the National Institutes of Health. NR 35 TC 14 Z9 14 U1 7 U2 63 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0027-8874 EI 1460-2105 J9 JNCI-J NATL CANCER I JI JNCI-J. Natl. Cancer Inst. PD DEC PY 2015 VL 107 IS 12 AR djv279 DI 10.1093/jnci/djv279 PG 11 WC Oncology SC Oncology GA CZ2YN UT WOS:000366970900015 PM 26464424 ER PT J AU Deschler, DG Herr, MW Kmiecik, JR Sethi, R Bunting, G AF Deschler, Daniel G. Herr, Marc W. Kmiecik, Joann R. Sethi, Rosh Bunting, Glenn TI Tracheoesophageal Voice After Total Laryngopharyngectomy Reconstruction: Jejunum Versus Radial Forearm Free Flap SO LARYNGOSCOPE LA English DT Article DE Total laryngopharyngectomy; jejunal free flap; radial forearm free flap; tracheoesophageal voice; quality of life ID ANTEROLATERAL THIGH FLAP; PHARYNGOESOPHAGEAL RECONSTRUCTION; FUNCTIONAL OUTCOMES; CERVICAL ESOPHAGUS; TOTAL LARYNGECTOMY; SWALLOWING OUTCOMES; RESTORATION; SPEECH; EXPERIENCE; PROSTHESIS AB Objective/Hypothesis: Tracheoesophageal (TE) voice restoration after laryngopharyngectomy with jejunal (Jej) flap and radial forearm flap (RFF) reconstruction has been successfully completed and studied for both techniques, but no direct comparisons exist. We undertook this study to directly compare TE voice in patients with total laryngopharyngectomy (TLP) reconstruction using the Jej and the RFF in a comprehensive and rigorous manner. Study Design: Retrospective cohort study. Methods: Forty patients after total laryngectomy or TLP were grouped by pharyngeal closure method: 18 primary closure (STL), 10 jejunal flap (TLP-Jej), and 12 radial forearm flap (TLP-RFF). Voice recordings underwent objective acoustic analysis and blinded subjective assessment by trained and naive listeners. Quality-of-life (QOL) assessments were obtained in all subjects using general health, disease-specific, and voice-specific survey tools. Results: All studies groups had similar demographics. Acoustic analysis demonstrated no differences in fundamental frequency or intensity levels. Subjective assessment demonstrated statistically significant inferior voice function of the reconstructed patients (TLP-Jej and TLP-RFF) compared to STL subjects for nearly all parameters tested by both naive and trained listeners. No differences were noted between TLP-Jej and TLP-RFF subjects for any of the parameters evaluated. Overall, trained listeners assessed TE voice more favorably compared to naive listeners in a significant manner. The three QOL surveys revealed no significant differences between TLP-Jej and TLP-RFF subjects. Conclusion: Tracheoesophageal voice in TLP-Jej and TLP-RFF subjects was equivalent but inferior to STL subjects. Reconstructed subjects had no differences in general, disease-specific, and voice-specific quality of life. C1 [Deschler, Daniel G.; Sethi, Rosh; Bunting, Glenn] Harvard Univ, Massachusetts Eye & Ear Infirm, Sch Med, Dept Otolaryngol Head & Neck Surg, Boston, MA 02114 USA. [Herr, Marc W.] Brooke Army Med Ctr, Dept Otolaryngol Head & Neck Surg, San Antonio, TX USA. [Kmiecik, Joann R.] Cleveland Clin, Head & Neck Inst, Cleveland, OH 44106 USA. RP Deschler, DG (reprint author), Harvard Univ, Massachusetts Eye & Ear Infirm, Sch Med, Dept Otolaryngol Head & Neck Surg,Acad Affairs, 243 Charles St, Boston, MA 02114 USA. EM daniel_deschler@meei.harvard.edu FU Synthes Grant from The American Head and Neck Society FX Partial financial support for this study was provided by the Synthes Grant awarded from The American Head and Neck Society. The authors have no additional funding, financial relationships, or conflicts of interest to disclose. NR 50 TC 1 Z9 1 U1 1 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0023-852X EI 1531-4995 J9 LARYNGOSCOPE JI Laryngoscope PD DEC PY 2015 VL 125 IS 12 BP 2715 EP 2721 DI 10.1002/lary.25404 PG 7 WC Medicine, Research & Experimental; Otorhinolaryngology SC Research & Experimental Medicine; Otorhinolaryngology GA CZ6CC UT WOS:000367187700027 PM 26198802 ER PT J AU Certal, V Silva, H Carvalho, C Costa-Pereira, A Azevedo, I Winck, J Capasso, R Camacho, M AF Certal, Victor Silva, Helder Carvalho, Carlos Costa-Pereira, Altamiro Azevedo, Ines Winck, Joao Capasso, Robson Camacho, Macario TI Model for Prediction of Pediatric OSA: Proposal for a Clinical Decision Rule SO LARYNGOSCOPE LA English DT Article DE Clinical decision rule; diagnosis; pediatric OSA ID OBSTRUCTIVE SLEEP-APNEA; QUESTIONNAIRE; METAANALYSIS; RELIABILITY; DISORDERS; DIAGNOSIS; VALIDITY; CHILDREN AB Objectives/Hypothesis: Obstructive sleep apnea (OSA) is a syndrome frequently diagnosed in children; however, it lacks optimal diagnostic methods. This study aimed to provide a clinical decision rule for predicting pediatric OSA using commonly available clinical information. Study Design: A prospective cohort study. Methods: Children between the ages of 3 to 6 years-old, referred for an otorhinolaryngology consultation due to clinical suspicion of OSA, were recruited from January to June 2014. At baseline age, weight, height, gender, body mass index, Pediatric Sleep Questionnaire (PSQ) scores, tonsil size, and oxygen desaturation index (ODI) were assessed. A logistic regression modeling was used with backward stepwise elimination to develop a prediction model. Results: Sixty-seven children were included with a mean age of 4.51 years. Of the 67 children included in this study, 25 (37.3%) subjects were diagnosed with pediatric OSA. Significant predictors of pediatric OSA in the final model (odds ratio, 95% confidence interval) included PSQ score (5.12; 3.3-6.5), ODI (1.34; 1.0-1.79) and tonsil size (6.7; 3.22-9.75). The final decision rule had a sensitivity of 88% and a specificity of 86%. The area under the receiver operating characteristic curve was 0.897. Conclusion: The proposed clinical decision rule, based on three readily available variables, is a promising discriminating instrument for prediction of OSA among children between 3 and 6 years. C1 [Costa-Pereira, Altamiro] Univ Porto, Ctr Res Hlth Technol & Informat Syst, P-4100 Oporto, Portugal. [Azevedo, Ines] Univ Porto, Dept Pediat, Fac Med, P-4100 Oporto, Portugal. [Winck, Joao] Univ Porto, Fac Med, Dept Pulmonol, P-4100 Oporto, Portugal. [Certal, Victor] Hosp CUF, Sleep Med Ctr, Dept Otorhinolaryngol, Oporto, Portugal. [Certal, Victor; Silva, Helder; Carvalho, Carlos] Hosp Sao Sebastiao, Dept Otorrinolaringol, P-4520 Sta Maria Da Feira, Portugal. [Capasso, Robson] Stanford Hosp & Clin, Div Sleep Surg, Dept Otolaryngol Head & Neck Surg, Stanford, CA USA. [Camacho, Macario] Tripler Army Med Ctr, Div Sleep Surg & Med, Dept Otolaryngol, Honolulu, HI 96859 USA. RP Certal, V (reprint author), Hosp Sao Sebastiao, Dept Otorrinolaringol, Rua Dr Candido Pinho, P-4520 Sta Maria Da Feira, Portugal. EM victorcertal@gmail.com RI FMUP, CINTESIS/C-6631-2014; Costa-Pereira, Altamiro/I-5987-2012; OI FMUP, CINTESIS/0000-0001-7248-2086; Costa-Pereira, Altamiro/0000-0001-8467-6398; Certal, Victor/0000-0002-1904-9504; Winck, Joao/0000-0002-4774-8206; Camacho, Macario/0000-0001-9200-9085 NR 16 TC 1 Z9 1 U1 7 U2 12 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0023-852X EI 1531-4995 J9 LARYNGOSCOPE JI Laryngoscope PD DEC PY 2015 VL 125 IS 12 BP 2823 EP 2827 DI 10.1002/lary.25438 PG 5 WC Medicine, Research & Experimental; Otorhinolaryngology SC Research & Experimental Medicine; Otorhinolaryngology GA CZ6CC UT WOS:000367187700045 PM 26154921 ER PT J AU Zhou, L Kammerer, C Giri, A Cho, K Sohn, Y AF Zhou, Le Kammerer, Catherine Giri, Anit Cho, Kyu Sohn, Yongho TI Microstructural Development and Ternary Interdiffusion in Ni-Mn-Ga Alloys SO METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE LA English DT Article ID SHAPE-MEMORY ALLOYS; FIELD-INDUCED STRAIN; MARTENSITE STABILIZATION; MULTICOMPONENT DIFFUSION; COMPOSITION DEPENDENCE; IRREVERSIBLE-PROCESSES; RECIPROCAL RELATIONS; CRYSTAL-STRUCTURE; HEUSLER ALLOYS; NIMNGA ALLOYS AB NiMnGa alloys functioning as either ferromagnetic shape memory alloys or magnetocaloric materials have both practical applications and fundamental research value. In this study, solid-to-solid diffusion couple experiments were carried out to investigate the phase equilibria, microstructural development, and interdiffusion behavior in Ni-Mn-Ga ternary alloys. Selected diffusion couples between pure Ni, Ni25Mn75 and four ternary off-stoichiometric NiMnGa alloys (i.e., Ni52Mn18Ga30, Ni46Mn30Ga24, Ni52Mn30Ga18, Ni58Mn18Ga24) were assembled and annealed at 1073 K, 1123 K, and 1173 K (800 degrees C, 850 degrees C, and 900 degrees C) for 480, 240, and 120 hours, respectively. At these high temperatures, the beta NiMnGa phase has a B2 crystal structure. The microstructure of the interdiffusion zone was examined by scanning electron microscopy and transmission electron microscopy. Concentration profiles across the interdiffusion zone were determined by electron probe micro analysis. Solubility values obtained for various phases were mostly consistent with the existing isothermal phase diagrams, but the phase boundary of the gamma(Mn) + beta two-phase region was slightly modified. In addition, equilibrium compositions for the gamma(Ni) and alpha' phases at 1173 K (900 degrees C) were also determined for the respective two-phase region. Both austenitic and martensitic phases were found at room temperature in each diffusion couple with a clear boundary. The compositions at the interfaces corresponded close to valence electron concentration (e/a) of 7.6, but trended to lower values when Mn increased to more than 35 at. pct. Average effective interdiffusion coefficients for the b phase over different compositional ranges were determined and reported in the light of temperature-dependence. Ternary interdiffusion coefficients were also determined and examined to assess the ternary diffusional interactions among Ni, Mn, and Ga. Ni was observed to interdiffuse the fastest, followed by Mn then Ga. Interdiffusion flux of Ni also has strong influences on the interdiffusion of Mn and Ga with large and negative cross interdiffusion coefficients, (D) over tilde (Ga)(MnNi) and (D) over tilde (Mn)(GaNi). The (D) over tilde (Ga)(NiNi) and (D) over tilde (Ga)(MnMn) ternary interdiffusion coefficients exhibited minimum values near 52 at. pct Ni concentration. (C) The Minerals, Metals & Materials Society and ASM International 2015 C1 [Zhou, Le; Kammerer, Catherine; Sohn, Yongho] Univ Cent Florida, Dept Mat Sci & Engn, Orlando, FL 32816 USA. [Zhou, Le; Kammerer, Catherine; Sohn, Yongho] Univ Cent Florida, Adv Mat Proc & Anal Ctr, Orlando, FL 32816 USA. [Giri, Anit] US Army Res Lab, TKC Global, Herndon, VA 20171 USA. [Cho, Kyu] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Sohn, Y (reprint author), Univ Cent Florida, Dept Mat Sci & Engn, Orlando, FL 32816 USA. EM Yongho.Sohn@ucf.edu RI Sohn, Yongho/A-8517-2010; Zhou, Le/H-9531-2016 OI Sohn, Yongho/0000-0003-3723-4743; Zhou, Le/0000-0001-8327-6667 FU U.S. Army Research Laboratory between University of Central Florida [W911NF-11-2-0020]; U.S. Army Research Laboratory FX This research was sponsored by the U.S. Army Research Laboratory through cooperative agreement #W911NF-11-2-0020 between University of Central Florida and the U.S. Army Research Laboratory. The views, opinions, and conclusions made in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the U.S. Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. The authors would also like to thank Mr. Timothy Delahanty at Pittsburgh Materials Technology, Pittsburgh, Pennsylvania, USA, for preparation of the alloys, and Mr. Thomas Beasley at Florida International University, Miami, Florida, USA, for the assistance with EMPA operation. NR 45 TC 1 Z9 1 U1 9 U2 27 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1073-5623 EI 1543-1940 J9 METALL MATER TRANS A JI Metall. Mater. Trans. A-Phys. Metall. Mater. Sci. PD DEC PY 2015 VL 46A IS 12 BP 5572 EP 5587 DI 10.1007/s11661-015-3123-x PG 16 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA CZ1YU UT WOS:000366902900012 ER PT J AU Douglas, CE Kulesh, DA Jaissle, JG Minogue, TD AF Douglas, Christina E. Kulesh, David A. Jaissle, James G. Minogue, Timothy D. TI Real-time reverse transcriptase polymerase chain reaction assays for Middle East Respiratory Syndrome SO MOLECULAR AND CELLULAR PROBES LA English DT Article DE RT-qPCR; MERS; Coronavirus; TaqMan (R)-MGB ID SYNDROME CORONAVIRUS; INFECTIONS AB Here we designed and tested two highly specific quantitative TaqMan (R)-MGB-based reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) assays for Middle East Respiratory Syndrome (MERS). The primers and probes for these assays were evaluated and found to have a limit of detection CLOD) of 0.005 plaque-forming units/PCR (pfu/PCR). Published by Elsevier Ltd. C1 [Douglas, Christina E.; Kulesh, David A.; Jaissle, James G.; Minogue, Timothy D.] US Army Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. RP Minogue, TD (reprint author), US Army Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. EM timothy.d.minogue.civ@mail.mil FU Defense Threat Reduction Agency (DTRA) [CB3901] FX This study was supported by the Defense Threat Reduction Agency (DTRA) project ID no. CB3901. The opinions, interpretations, conclusions, and recommendations in this report are those of the authors and are not necessarily endorsed by the U.S. Army. NR 6 TC 1 Z9 1 U1 1 U2 3 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0890-8508 J9 MOL CELL PROBE JI Mol. Cell. Probes PD DEC PY 2015 VL 29 IS 6 BP 511 EP 513 DI 10.1016/j.mcp.2015.09.001 PG 3 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Cell Biology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Cell Biology GA CZ6LD UT WOS:000367211900027 PM 26365228 ER PT J AU Pan, H Piermartiri, TCB Chen, J McDonough, J Oppel, C Driwech, W Winter, K McFarland, E Black, K Figueiredo, T Grunberg, N Marini, AM AF Pan, Hongna Piermartiri, Tetsade C. B. Chen, Jun McDonough, John Oppel, Craig Driwech, Wafae Winter, Kristin McFarland, Emylee Black, Katelyn Figueiredo, Taiza Grunberg, Neil Marini, Ann M. TI Repeated systemic administration of the nutraceutical alpha-linolenic acid exerts neuroprotective efficacy, an antidepressant effect and improves cognitive performance when given after soman exposure SO NEUROTOXICOLOGY LA English DT Article DE Rat; Alpha-linolenic acid; Soman; Behavior; Neuroprotection; Neurodegeneration; Passive avoidance; Porsolt forced swim test ID POSTTRAUMATIC-STRESS-DISORDER; SUBWAY SARIN ATTACK; TRAUMATIC BRAIN-INJURY; FORCED-SWIMMING TEST; PASSIVE-AVOIDANCE; INDUCED SEIZURES; TOKYO SUBWAY; LONG-TERM; NEUROTROPHIC FACTOR; INDUCED NEUROPATHOLOGY AB Exposure to nerve agents results in severe seizures or status epilepticus caused by the inhibition of acetylcholinesterase, a critical enzyme that breaks down acetylcholine to terminate neurotransmission. Prolonged seizures cause brain damage and can lead to long-term consequences. Current counter-measures are only modestly effective against the brain damage supporting interest in the evaluation of new and efficacious therapies. The nutraceutical alpha-linolenic acid (LIN) is an essential omega-3 polyunsaturated fatty acid that has a wide safety margin. Previous work showed that a single intravenous injection of alpha-linolenic acid (500 nmol/kg) administered before or after soman significantly protected against soman-induced brain damage when analyzed 24 h after exposure. Here, we show that administration of three intravenous injections of alpha-linolenic acid over a 7 day period after soman significantly improved motor performance on the rotarod, enhanced memory retention, exerted an anti-depressant-like activity and increased animal survival. This dosing schedule significantly reduced soman-induced neuronal degeneration in four major vulnerable brain regions up to 21 days. Taken together, alpha-linolenic acid reduces the profound behavioral deficits induced by soman possibly by decreasing neuronal cell death, and increases animal survival. Published by Elsevier Inc. C1 [Pan, Hongna; Chen, Jun; Marini, Ann M.] Uniformed Serv Univ Hlth Sci, Dept Neurol, Bethesda, MD 20814 USA. [Piermartiri, Tetsade C. B.] Uniformed Serv Univ Hlth Sci, Mol & Cellular Biol Grad Sch Program, Bethesda, MD 20814 USA. [Figueiredo, Taiza] Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, Bethesda, MD 20814 USA. [Grunberg, Neil] Uniformed Serv Univ Hlth Sci, Dept Med & Clin Psychol, Bethesda, MD 20814 USA. [Chen, Jun; McDonough, John; Oppel, Craig; Driwech, Wafae; Winter, Kristin; McFarland, Emylee; Black, Katelyn] US Army, Med Res Inst Chem Def, Div Res, Pharmacol Branch, Aberdeen Proving Ground, MD 21010 USA. RP Marini, AM (reprint author), Uniformed Serv Univ Hlth Sci, Dept Neurol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM Ann.marini@usuhs.edu OI Piermartiri, Tetsade/0000-0002-9773-6983 FU Defense Threat Reduction Agency-Joint Science and Technology Office, Medical ST Division [CBM.NEURO.01.10.US.012, CBM.NEURO.01.10. US.019] FX This work was supported by the Defense Threat Reduction Agency-Joint Science and Technology Office, Medical S&T Division (Grant Nos. CBM.NEURO.01.10.US.012 and CBM.NEURO.01.10. US.019) to A.M.M. NR 123 TC 1 Z9 1 U1 1 U2 10 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0161-813X EI 1872-9711 J9 NEUROTOXICOLOGY JI Neurotoxicology PD DEC PY 2015 VL 51 BP 38 EP 50 DI 10.1016/j.neuro.2015.09.006 PG 13 WC Neurosciences; Pharmacology & Pharmacy; Toxicology SC Neurosciences & Neurology; Pharmacology & Pharmacy; Toxicology GA CZ2SC UT WOS:000366953900005 PM 26386148 ER PT J AU Wojnicki, FHE Johnson, DS Charny, G Corwin, RLW AF Wojnicki, F. H. E. Johnson, D. S. Charny, G. Corwin, R. L. W. TI Development of bingeing in rats altered by a small operant requirement SO PHYSIOLOGY & BEHAVIOR LA English DT Article DE Binge eating; Dietary fat; Operant behavior; Rats; Shortening ID LIMITED ACCESS CONDITIONS; FOOD-INTAKE; SCHEDULE; FAT; BACLOFEN; BEHAVIOR; SIZE; REINFORCEMENT; PERFORMANCE; RACLOPRIDE AB Previous studies have shown that providing an optional food for a brief period of time to non-food deprived rats on an intermittent basis in the home cage engenders significantly more intake (binge-type behavior) than when the optional food is provided for a brief period on a daily basis. Experiment I examined the effects of placing a small operant response requirement on access to an optional food (vegetable shortening) on the establishment of binge-type behavior. Experiment 2 examined the effects of different schedules of reinforcement, a period of abstinence from shortening, and 24 h of food deprivation on established binge-type behavior. In Experiment 1 the group of rats with 30-min access to shortening on an intermittent basis in their home cages (IC) consumed significantly more shortening than the group with 30-min daily access in the home cage (DC). The group with 30-min intermittent access in an operant chamber (10 group) earned significantly more reinforcers than the group with 30-min daily access in an operant chamber (DO). In Experiment 2, the 10 group earned significantly more reinforcers than the DO group regardless of the response cost, the period of shortening abstinence, and overnight food deprivation. These results demonstrate that while intermittent access generates binge-type eating, the size of the binge (intake) can be altered by different contingency arrangements. (C) 2015 Elsevier Inc. All rights reserved. C1 [Wojnicki, F. H. E.; Corwin, R. L. W.] Penn State Univ, Chandlee Lab 110, Nutr Sci, University Pk, PA 16801 USA. [Johnson, D. S.] Univ Penn, Sch Med, Dept Pathol & Lab Med, Virol, Philadelphia, PA 19104 USA. [Charny, G.] Womack Army Med Ctr, Dept Emergency Med, Ft Bragg, NC 28310 USA. RP Corwin, RLW (reprint author), Penn State Univ, Coll Hlth & Human Dev, Dept Nutr Sci, Chandlee Lab 110, University Pk, PA 16801 USA. EM rxc13@psu.edu FU [MH67943] FX Support for this study by MH67943 (RLC). NR 40 TC 1 Z9 1 U1 1 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0031-9384 J9 PHYSIOL BEHAV JI Physiol. Behav. PD DEC 1 PY 2015 VL 152 BP 112 EP 118 DI 10.1016/j.physbeh.2015.09.009 PN A PG 7 WC Psychology, Biological; Behavioral Sciences SC Psychology; Behavioral Sciences GA CZ2RZ UT WOS:000366953600016 PM 26375821 ER PT J AU McAninch, IM Palmese, GR Lenhart, JL La Scala, JJ AF McAninch, Ian M. Palmese, Giuseppe R. Lenhart, Joseph L. La Scala, John J. TI DMA Testing of Epoxy Resins: The Importance of Dimensions SO POLYMER ENGINEERING AND SCIENCE LA English DT Article ID DYNAMIC-MECHANICAL ANALYSIS; POLY(ETHER ETHER KETONE); ANHYDRIDE-CURED EPOXY; THERMAL-PROPERTIES; POLYMER NETWORKS; CROSS-LINKING; MODIFIED BISMALEIMIDE; DIELECTRIC-PROPERTIES; FRACTURE-TOUGHNESS; CARBON NANOTUBES AB Dynamic mechanical analysis is commonly used to characterize thermoset polymers at temperatures ranging from well below to well above their glass transition temperatures. Many sample fixtures are available; however, the best clamp and best sample dimensions for a given material are not often readily apparent. Five different epoxy amine networks with glass transitions spanning over 100 degrees C were characterized on three-point bending, dual cantilever, and single cantilever clamps with both constant thickness and constant span-to-thickness. Glassy modulus values were accurately measured on all clamps provided span-to-thickness ratios >10 were maintained. Thermal expansion and decreasing sample stiffness with increasing temperature greatly affect measurements in the rubbery region resulting in single cantilever clamps being best suited to measure rubbery data. (C) 2015 Society of Plastics Engineers C1 [McAninch, Ian M.; Lenhart, Joseph L.; La Scala, John J.] US Army Res Lab, RDRL WMM C, Aberdeen Proving Ground, MD 21005 USA. [McAninch, Ian M.; Palmese, Giuseppe R.] Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA. RP La Scala, JJ (reprint author), US Army Res Lab, RDRL WMM C, Aberdeen Proving Ground, MD 21005 USA. EM john.j.lascala.civ@mail.mil OI McAninch, Ian/0000-0002-9190-2936 NR 100 TC 6 Z9 6 U1 11 U2 42 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0032-3888 EI 1548-2634 J9 POLYM ENG SCI JI Polym. Eng. Sci. PD DEC PY 2015 VL 55 IS 12 BP 2761 EP 2774 DI 10.1002/pen.24167 PG 14 WC Engineering, Chemical; Polymer Science SC Engineering; Polymer Science GA CZ1BA UT WOS:000366839500010 ER PT J AU Cai, HQ Dumais, RE AF Cai, Huaqing Dumais, Robert E., Jr. TI Object-Based Evaluation of a Numerical Weather Prediction Model's Performance through Forecast Storm Characteristic Analysis SO WEATHER AND FORECASTING LA English DT Article ID PRECIPITATION FORECASTS; PART I; VERIFICATION; SYSTEMS; PREDICTABILITY; METHODOLOGY; TRACKING AB Traditional pixel-versus-pixel forecast evaluation scores such as the critical success index (CSI) provide a simple way to compare the performances of different forecasts; however, they offer little information on how to improve a particular forecast. This paper strives to demonstrate what additional information an object-based forecast evaluation tool such as the Method for Object-Based Diagnostic Evaluation (MODE) can provide in terms of assessing numerical weather prediction models' convective storm forecasts. Forecast storm attributes evaluated by MODE in this paper include storm size, intensity, orientation, aspect ratio, complexity, and number of storms. Three weeks of the High Resolution Rapid Refresh (HRRR) model's precipitation forecasts during the summer of 2010 over the eastern two-thirds of the contiguous United States were evaluated as an example to demonstrate the methodology. It is found that the HRRR model was able to forecast convective storm characteristics rather well either as a function of time of day or as a function of storm size, although significant bias does exist, especially in terms of storm number and storm size. Another interesting finding is that the model's ability of forecasting new storm initiation varies substantially by regions, probably as a result of its different skills in forecasting convection driven by different forcing mechanisms (i.e., diurnal heating vs synoptic-scale frontal systems). C1 [Cai, Huaqing] Natl Ctr Atmospher Res, Boulder, CO 80307 USA. [Dumais, Robert E., Jr.] US Army, Res Lab, White Sands Missile Range, NM 88002 USA. RP Cai, HQ (reprint author), US Army, Res Lab, White Sands Missile Range, NM 88002 USA. EM huaqing.cai.civ@mail.mil FU Federal Aviation Administration (FAA); U.S. Army Research Laboratory FX This research is in response to requirements and funding by the Federal Aviation Administration (FAA). HC is also partially supported by the U.S. Army Research Laboratory. The views expressed are those of the authors and do not necessarily represent the official policy or position of the FAA or the U.S. Army. NR 34 TC 2 Z9 2 U1 1 U2 6 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 0882-8156 EI 1520-0434 J9 WEATHER FORECAST JI Weather Forecast. PD DEC PY 2015 VL 30 IS 6 BP 1451 EP 1468 DI 10.1175/WAF-D-15-0008.1 PG 18 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA CZ3DX UT WOS:000366985700001 ER PT J AU Napolitano, M AF Napolitano, Marc TI 'Utterly Baffled and Beaten, What Was the Lonely and Brokenhearted Man to Do?': Narration, Ambiguity, and Sympathy in Stanley Kubrick's Barry Lyndon SO ADAPTATION-THE JOURNAL OF LITERATURE ON SCREEN STUDIES LA English DT Article DE Stanley Kubrick; William Makepeace Thackeray; Barry Lyndon; adaptation; unreliable narrator; narration AB Stanley Kubrick's Barry Lyndon is regarded as one of the most aesthetically beautiful films of all time, though its painterly cinematography is counterbalanced by the harshness, coldness, and melancholy of the onscreen narrative. This divergence is evocative of traditional narratological debates over the reliability of narrators: a narrator's unreliability is typically measured by his concurrence or divergence with the implied author. Such debates are essential to any discussion of Kubrick's Barry Lyndon and its literary source, William Makepeace Thackeray's The Luck of Barry Lyndon: while Thackeray's Barry epitomises the traits of the unreliable narrator, Kubrick's third-person narrator has proved a controversial figure, with numerous scholars debating his reliability based on his concurrence (or conflict) with the onscreen narrative. This paper argues that the fundamental reliability of Kubrick's narrator is not simply based on his relationship with the visual narrative, but also on his serving as a manifestation of the voice of the novel's implied author. This convergence between the authorial voices of Kubrick and Thackeray through the voice-over narration ultimately supports the onscreen narrator's assessment of Barry's rise and fall but simultaneously promotes sympathy for both incarnations of Redmond Barry. C1 [Napolitano, Marc] US Mil Acad, Dept English & Philosophy, West Point, NY 10996 USA. RP Napolitano, M (reprint author), US Mil Acad, Dept English & Philosophy, West Point, NY 10996 USA. EM marc.napolitano@usma.edu NR 24 TC 0 Z9 0 U1 0 U2 1 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1755-0637 EI 1755-0645 J9 ADAPTATION-UK JI Adaptation PD DEC PY 2015 VL 8 IS 3 SI SI BP 330 EP 344 DI 10.1093/adaptation/apv005 PG 15 WC Film, Radio, Television; Literature SC Film, Radio & Television; Literature GA CY4HU UT WOS:000366370000005 ER PT J AU Velasco, JM Valderama, MT Lopez, MN Chua, D Latog, R Roque, V Corpuz, J Klungthong, C Rodpradit, P Hussem, K Poolpanichupatam, Y Macareo, L Fernandez, S Yoon, IK AF Velasco, John Mark Valderama, Maria Theresa Lopez, Maria Nila Chua, Domingo, Jr. Latog, Rene, II Roque, Vito, Jr. Corpuz, June Klungthong, Chonticha Rodpradit, Prinyada Hussem, Kittinun Poolpanichupatam, Yongyuth Macareo, Louis Fernandez, Stefan Yoon, In-Kyu TI Chikungunya Virus Infections among Patients with Dengue-Like Illness at a Tertiary Care Hospital in the Philippines, 2012-2013 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID SOUTHEAST-ASIA; REUNION ISLAND; CONCURRENT OUTBREAKS; VIRAL DISEASES; FEVER; EPIDEMIC; CHILDREN; PACIFIC; TRANSMISSION; REEMERGENCE AB Chikungunya virus (CHIKV) often co-circulates with dengue virus (DENV). A cross-sectional surveillance study was conducted at a tertiary hospital in Manila, Philippines, to describe the prevalence and characteristics of DENY and CHIKV infections among patients seeking care for dengue-like illness. Acute blood samples from patients 6 months of age clinically diagnosed with dengue from November 2012 to December 2013 underwent reverse transcription polymerase chain reaction (RT-PCR) to detect DENY and CHIKV RNA. A total of 118 patients with clinically diagnosed dengue (age range = 1-89 years, mean = 22 years; male-to-female ratio = 1.51) were tested by DENY RT-PCR; 40 (34%) were DENY PCR-positive (age range = 1-45 years, mean = 17 years). All DENY serotypes were detected: 11 (28%) DENY-1, 6 (15%) DENV-2, 6 (15%) DENV-3, and 17 (42%) DENV-4. Of 112 patients clinically diagnosed with dengue and tested by CHIKV RT-PCR, 11 (10%) were CHIKV PCR-positive (age range = 2-47 years, mean = 20.3 years). No coinfections were detected. Presenting signs/symptoms did not differ between DENY- and CHIKV-positive cases. Sequencing of envelope 1 gene from two CHIKV PCR-positive samples showed Asian genotype. This study highlights the potential for misdiagnosis of medically attended CHIKV infections as DENY infection and the difficulty in clinically differentiating dengue and chikungunya based on presenting signs/symptoms alone. This underscores the necessity for diagnostic laboratory tests to distinguish CHIKV infections in the background of actively co-circulating DENY. C1 [Velasco, John Mark; Klungthong, Chonticha; Rodpradit, Prinyada; Hussem, Kittinun; Poolpanichupatam, Yongyuth; Macareo, Louis; Fernandez, Stefan; Yoon, In-Kyu] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Lopez, Maria Nila] Armed Forces Philippines Med Serv Sch, Quezon City, Philippines. Armed Forces Philippines Med Ctr, Dept Res & Training, Quezon City, Philippines. Dept Hlth, Epidemiol Bur, Manila, Philippines. [Velasco, John Mark; Valderama, Maria Theresa] Armed Forces Philippines Med Ctr, V Luna Gen Hosp, Philippines AFRIMS Virol Res Unit, Quezon City, Philippines. [Chua, Domingo, Jr.; Latog, Rene, II] Armed Forces Philippines Med Ctr, V Luna Gen Hosp, Dept Res & Training, Quezon City, Philippines. [Roque, Vito, Jr.; Corpuz, June] Dept Hlth, Epidemiol Bur, Manila, Philippines. RP Velasco, JM (reprint author), Armed Forces Res Inst Med Sci, Dept Virol, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. EM velascojm@afrims.org; valderamamg.ca@afrims.org; manila28@yahoo.com.ph; dachuajr@gmail.com; latogreneii@yahoo.com; vitogroquejr@gmail.com; jcbcorpuz@gmail.com; chontichak.fsn@afrims.org; prinyadar.ca@afrims.org; kittinunh.fsn@afrims.org; yongyuthp.fsn@afrims.org; louis.macareo.mil@afrims.org; stefaniernandez.mil@afrims.org; inkyu.yoon.mil@afrims.org FU U.S. Armed Forces Health Surveillance Center-Global Emerging Infections Surveillance and Response Systems (AFHSC-GEIS) FX This study was funded by the U.S. Armed Forces Health Surveillance Center-Global Emerging Infections Surveillance and Response Systems (AFHSC-GEIS). NR 47 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2015 VL 93 IS 6 BP 1318 EP 1324 DI 10.4269/ajtmh.15-0332 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA CY6TD UT WOS:000366540800032 PM 26416109 ER PT J AU Yang, Y Garver, LS Bingham, KM Hang, J Jochirn, RC Davidson, SA Richardson, JH Jarman, RG AF Yang, Yu Garver, Lindsey S. Bingham, Karen M. Hang, Jun Jochirn, Ryan C. Davidson, Silas A. Richardson, Jason H. Jarman, Richard G. TI Feasibility of Using the Mosquito Blood Meal for Rapid and Efficient Human and Animal Virus Surveillance and Discovery SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID SPECIMEN COLLECTION; FTA CARDS; IDENTIFICATION; EXTRACTION; PATHOGENS; DIAGNOSIS; STORAGE; RNA; DNA AB Mosquito blood meals taken from humans and animals potentially represent a useful source of blood for the detection of blood-borne pathogens. In this feasibility study, Anopheles stephensi mosquitoes were fed with blood meals spiked with dengue virus type 2 (DENV-2) and harvested at serial time points. These mosquitoes are not competent vectors, and the virus is not expected to replicate. Ingested blood was spotted on Whatman VIA cards and stored at room temperature. Mosquito abdomens were removed and stored at 80 degrees C. Control blood meal aliquots were stored in vials or applied onto PTA cards. After 4 weeks of storage, the samples were extracted using beadbeating and QIAamp Viral RNA kit (Qiagen Sciences, Germantown, MD). Recovered viral RNA was analyzed by DENV-2 TaqMan RT-PCR assay and next-generation sequencing (NGS). Overall viral RNA recovery efficiency was 15% from the directly applied dried blood spots and approximately 20% or higher for dried blood spots made by blotting mosquito midgut on PTA cards. Viral RNA in mosquito-ingested blood decreases over time, but remains detectable 24 hours after blood feeding. The viral sequences in FTA-stored specimens can be maintained at room temperature. The strategy has the potential utility in expedited zoonotic virus discovery and blood-borne pathogen surveillance C1 [Yang, Yu; Hang, Jun; Jarman, Richard G.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD 20910 USA. [Garver, Lindsey S.; Davidson, Silas A.] Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD 20910 USA. [Bingham, Karen M.] Walter Reed Army Inst Res, Malaria Res Program, Silver Spring, MD 20910 USA. [Jochirn, Ryan C.] Vet Diagnost Technol Inc, Wheat Ridge, CO USA. [Richardson, Jason H.] Armed Forces Pest Management Board, Silver Spring, MD USA. RP Hang, J (reprint author), Walter Reed Army Inst Res, Viral Dis Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM yu.yang2.ctr@mail.mil; lindsey.s.garverbaldwin.ctr@mail.mil; karen.m.bingham2.ctr@mail.mil; jun.hang.civ@mail.mil; ryan.jochim@gmail.com; silas.davidson.mil@afrims.org; jason.h.richardson.mil@mail.mil; richard.g.jarman.mil@mail.mil FU Global Emerging Infections Surveillance and Response System (GEIS), a Division of the Armed Forces Health Surveillance Center; Military Infectious Diseases Research Programs (MIDRP) FX This work was supported by the Global Emerging Infections Surveillance and Response System (GEIS), a Division of the Armed Forces Health Surveillance Center and the Military Infectious Diseases Research Programs (MIDRP). NR 28 TC 1 Z9 1 U1 2 U2 4 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2015 VL 93 IS 6 BP 1377 EP 1382 DI 10.4269/ajtmh.15-0440 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA CY6TD UT WOS:000366540800042 PM 26416112 ER PT J AU Esposito, ER Whitehead, JMA Wilken, JM AF Esposito, Elizabeth Russell Whitehead, Jennifer M. Aldridge Wilken, Jason M. TI Sound limb loading in individuals with unilateral transfemoral amputation across a range of walking velocities SO CLINICAL BIOMECHANICS LA English DT Article DE Amputee; Knee osteoarthritis; Prosthetic; Military; Traumatic; Speed; Kinetics ID COMPARTMENT KNEE OSTEOARTHRITIS; QUADRICEPS STRENGTH; DISEASE PROGRESSION; ARTICULAR-CARTILAGE; PHYSICAL-ACTIVITY; ADDUCTION TORQUE; GAIT PATTERNS; AMPUTEE GAIT; RISK-FACTOR; IN-VITRO AB Background: Individuals with unilateral transfemoral amputation demonstrate significantly increased rates of osteoarthritis in their sound knee. This increased risk is likely the result of altered knee mechanical loading and gait compensations resulting from limited function in the prosthetic limb. Altered knee loading as calculated using loading rates and peak external knee adduction moments and impulses have been associated with both the development and progression of knee osteoarthritis in other populations. The purpose of this study was to determine if young individuals with transfemoral amputation demonstrate biomechanical indicators of increased knee osteoarthritis risk. Methods: Fourteen young male Service Members with unilateral transfemoral amputation and 14 able-bodied service members underwent biomechanical gait analysis at three standardized walking velocities. A two-way ANOVA (group x speed) with unpaired comparisons with Bonferroni-Holm post-hoc corrections assessed statistical significance and effect sizes (d) were calculated. Findings: Normalized peak external knee adduction moments and impulses were 25.7% (P < 0.014, d > 0.994) and 27.1% (P < 0.012, d > 1.019) lower, respectively, in individuals with trans-femoral amputation than controls when averaged across speeds, and effect sizes were large. External knee flexor moments were not, however, different between groups and effect sizes were generally small (P > 0.380, d <0338). Maximal loading rates were significantly greater in individuals with amputation and effect sizes were large (P <0.001, d > 1.644). Interpretation: Individuals with transfemoral amputation did not demonstrate biomechanical risk factors for high medial compartment knee joint loads, but the increased loading rates could place the sound knee at greater risk for cartilage or other tissue damage, even if not localized to the medial compartment Published by Elsevier Ltd. C1 Brooke Army Med Ctr, JBSA, Dept Orthopaed & Rehabil, Ctr Intrepid, Ft Sam Houston, TX 78234 USA. RP Esposito, ER (reprint author), Ctr Intrepid, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Erussell.kin@gmail.com FU Telemedicine and Advanced Technology Research Center; Center for Rehabilitation Sciences Research, Uniformed Services University of the Health Sciences, Bethesda, MD FX This study was supported by the Telemedicine and Advanced Technology Research Center and the Center for Rehabilitation Sciences Research, Uniformed Services University of the Health Sciences, Bethesda, MD. NR 63 TC 0 Z9 0 U1 4 U2 12 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0268-0033 EI 1879-1271 J9 CLIN BIOMECH JI Clin. Biomech. PD DEC PY 2015 VL 30 IS 10 BP 1049 EP 1055 DI 10.1016/j.clinbiomech.2015.09.008 PG 7 WC Engineering, Biomedical; Orthopedics; Sport Sciences SC Engineering; Orthopedics; Sport Sciences GA CZ0JF UT WOS:000366790400005 ER PT J AU Esposito, ER Choi, HS Owens, JG Blanck, RV Wilken, JM AF Esposito, Elizabeth Russell Choi, Harmony S. Owens, Johnny G. Blanck, Ryan V. Wilken, Jason M. TI Biomechanical response to ankle-foot orthosis stiffness during running SO CLINICAL BIOMECHANICS LA English DT Article DE Limb salvage; IDEO; Military; Mechanical work; Joint stiffness; Kinetics; Kinematics ID LOWER-EXTREMITY TRAUMA; OPERATION ENDURING FREEDOM; LIMB-LENGTH DISCREPANCY; PLANTARFLEXOR WEAKNESS; PHYSICAL-THERAPY; GAIT ASYMMETRY; IRAQI FREEDOM; AMPUTATION; WALKING; PERFORMANCE AB Background: The Intrepid Dynamic Exoskeletal Orthosis (IDEO) is an ankle-foot orthosis developed to address the high rates of delayed amputation in the military. Its use has enabled many wounded Service Members to run again. During running, stiffness is thought to influence an orthosis' energy storage and return mechanical properties. This study examined the effect of orthosis stiffness on running biomechanics in patients with lower limb impairments who had undergone unilateral limb salvage. Methods: Ten patients with lower limb impairments underwent gait analysis at a self-selected running velocity. 1. Nominal (clinically-prescribed), 2. Stiff (20% stiffer than nominal), and 3. Compliant (20% less stiff than nominal) ankle-foot orthosis stiffnesses were tested. Findings: Ankle joint stiffness was greatest in the stiffest strut and lowest in the compliant strut, however ankle mechanical work remained unchanged. Speed, stride length, cycle time, joint angles, moments, powers, and ground reaction forces were not significantly different among stiffness conditions. Ankle joint kinematics and ankle, knee and hip kinetics were different between limbs. Ankle power, in particular, was lower in the injured limb. Interpretation: Ankle-foot orthosis stiffness affected ankle joint stiffness but did not influence other biomechanical parameters of running in individuals with unilateral limb salvage. Foot strike asymmetries may have influenced the kinetics of running. Therefore, a range of stiffness may be clinically appropriate when prescribing ankle-foot orthoses for active individuals with limb salvage. Published by Elsevier Ltd. C1 [Esposito, Elizabeth Russell; Choi, Harmony S.; Owens, Johnny G.; Blanck, Ryan V.; Wilken, Jason M.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ctr Intrepid, Ft Sam Houston, TX 78234 USA. RP Esposito, ER (reprint author), Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ctr Intrepid, Ft Sam Houston, TX 78234 USA. EM erussell.kin@gmail.com FU Center for Rehabilitation Sciences Research (CRSR), Department of Physical Medicine and Rehabilitation, Uniformed Services University of Health Sciences, Bethesda, MD FX The authors gratefully acknowledge Derek Haight, Jennifer Aldridge Whitehead, Kelly Rodriguez and Dr. Deanna Gates at the Center for the Intrepid for their assistance with data collection and processing, and Nicole Harper and Dr. Richard Neptune at the University of Texas for design and fabrication of the struts. Support for this study was provided by the Center for Rehabilitation Sciences Research (CRSR), Department of Physical Medicine and Rehabilitation, Uniformed Services University of Health Sciences, Bethesda, MD. NR 55 TC 1 Z9 1 U1 3 U2 15 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0268-0033 EI 1879-1271 J9 CLIN BIOMECH JI Clin. Biomech. PD DEC PY 2015 VL 30 IS 10 BP 1125 EP 1132 DI 10.1016/j.clinbiomech.2015.08.014 PG 8 WC Engineering, Biomedical; Orthopedics; Sport Sciences SC Engineering; Orthopedics; Sport Sciences GA CZ0JF UT WOS:000366790400018 ER PT J AU Keevin, TM Nico, LG Taphorn, DC AF Keevin, Thomas M. Nico, Leo G. Taphorn, Donald C. TI Jamie Edward Thomerson (1935-2015) OBITUARY SO COPEIA LA English DT Biographical-Item C1 [Keevin, Thomas M.] US Army Corps Engineers, St Louis, MO 63103 USA. [Nico, Leo G.] US Geol Survey, Gainesville, FL 32653 USA. RP Keevin, TM (reprint author), US Army Corps Engineers, 1222 Spruce St, St Louis, MO 63103 USA. EM Keevintm@yahoo.com; lnico@usgs.gov; Taphorn@gmail.com NR 2 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC ICHTHYOLOGISTS & HERPETOLOGISTS PI MIAMI PA MAUREEN DONNELLY, SECRETARY FLORIDA INT UNIV BIOLOGICAL SCIENCES, 11200 SW 8TH STREET, MIAMI, FL 33199 USA SN 0045-8511 EI 1938-5110 J9 COPEIA JI Copeia PD DEC PY 2015 VL 103 IS 4 BP 1096 EP 1101 DI 10.1643/OT-15-331 PG 6 WC Zoology SC Zoology GA CY8SX UT WOS:000366679700026 ER PT J AU Westbrook, CJ Karl, JA Wiseman, RW Mate, S Koroleva, G Garcia, K Sanchez-Lockhart, M O'Connor, DH Palacios, G AF Westbrook, Catherine J. Karl, Julie A. Wiseman, Roger W. Mate, Suzanne Koroleva, Galina Garcia, Karla Sanchez-Lockhart, Mariano O'Connor, David H. Palacios, Gustavo TI No assembly required: Full-length MHC class I allele discovery by PacBio circular consensus sequencing SO HUMAN IMMUNOLOGY LA English DT Article DE MHC class I; Cynomolgus macaques; Single-molecule real-time circular consensus sequencing (SMRT-CCS); PacBio ID MAJOR HISTOCOMPATIBILITY COMPLEX; IMMUNODEFICIENCY VIRUS-REPLICATION; MAURITIAN CYNOMOLGUS MACAQUES; RHESUS MACAQUES; MOLECULES; HAPLOTYPES; PLATFORMS AB Single-molecule real-time (SMRT) sequencing technology with the Pacific Biosciences (PacBio) RS II platform offers the potential to obtain full-length coding regions (similar to 1100-bp) from MHC class I cDNAs. Despite the relatively high error rate associated with SMRT technology, high quality sequences can be obtained by circular consensus sequencing (CCS) due to the random nature of the error profile. In the present study we first validated the ability of SMRT-CCS to accurately identify class I transcripts in Mauritian-origin cynomolgus macaques (Macaca fascicularis) that have been characterized previously by cloning and Sanger-based sequencing as well as pyrosequencing approaches. We then applied this SMRT-CCS method to characterize 60 novel full-length class I transcript sequences expressed by a cohort of cynomolgus macaques from China. The SMRT-CCS method described here provides a straightforward protocol for characterization of unfragmented single-molecule cDNA transcripts that will potentially revolutionize MHC class I allele discovery in nonhuman primates and other species. Published by Elsevier Inc. on behalf of American Society for Histocompatibility and Immunogenetics. C1 [Westbrook, Catherine J.; Mate, Suzanne; Koroleva, Galina; Garcia, Karla; Sanchez-Lockhart, Mariano; Palacios, Gustavo] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Karl, Julie A.; Wiseman, Roger W.; O'Connor, David H.] Univ Wisconsin, Wisconsin Natl Primate Res Ctr, Madison, WI 53711 USA. [O'Connor, David H.] Univ Wisconsin, Dept Pathol & Lab Med, Madison, WI 53705 USA. RP Sanchez-Lockhart, M (reprint author), 1425 Porter St, Ft Detrick, MD 21702 USA. EM Mariano.sanchez-lockhart.ctr@mail.mil RI Palacios, Gustavo/I-7773-2015; OI Palacios, Gustavo/0000-0001-5062-1938; o'connor, david/0000-0003-2139-470X FU Defense Threat Reduction Agency under USAMRIID project [3174512]; National Institute of Allergy and Infectious Diseases [HHSN272201100013C]; Research Facilities Improvement Program [RR15459-01, RR020141-01] FX This work was supported by Defense Threat Reduction Agency under USAMRIID project number 3174512. This study was also supported by the National Institute of Allergy and Infectious Diseases (HHSN272201100013C) and was conducted in part at a facility constructed with support from the Research Facilities Improvement Program (RR15459-01, RR020141-01). NR 29 TC 8 Z9 9 U1 3 U2 10 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0198-8859 EI 1879-1166 J9 HUM IMMUNOL JI Hum. Immunol. PD DEC PY 2015 VL 76 IS 12 SI SI BP 891 EP 896 DI 10.1016/j.humimm.2015.03.022 PG 6 WC Immunology SC Immunology GA CY5HE UT WOS:000366437900003 PM 26028281 ER PT J AU Pradhan, NR McCreary, A Rhodes, D Lu, ZG Feng, SM Manousakis, E Smirnov, D Namburu, R Dubey, M Walker, ARH Terrones, H Terrones, M Dobrosavljevic, V Balicas, L AF Pradhan, Nihar R. McCreary, Amber Rhodes, Daniel Lu, Zhengguang Feng, Simin Manousakis, Efstratios Smirnov, Dmitry Namburu, Raju Dubey, Madan Walker, Angela R. Hight Terrones, Humberto Terrones, Mauricio Dobrosavljevic, Vladimir Balicas, Luis TI Metal to Insulator Quantum-Phase Transition in Few-Layered ReS2 SO NANO LETTERS LA English DT Article DE Transition metal dichalcogenides; rhenium disulfide; Raman scattering; field-effect transistor; field-effect mobilities; metal-insulator transition ID FIELD-EFFECT TRANSISTORS; 2 DIMENSIONS; MOS2 TRANSISTORS; MOLYBDENUM-DISULFIDE; SINGLE-LAYER; WS2; LOCALIZATION; MONOLAYER; HALL; MOBILITIES AB In ReS2, a layer-independent direct band gap of 1.5 eV implies a potential for its use in optoelectronic applications. ReS2 crystallizes in the 1T'-structure, which leads to anisotropic physical properties and whose concomitant electronic structure might host a nontrivial topology. Here, we report an overall evaluation of the anisotropic Raman response and the transport properties of few-layered ReS2 field-effect transistors. We find that ReS2 exfoliated on SiO2 behaves as an n-type semiconductor with an intrinsic carrier mobility surpassing mu(i) similar to 30 cm(2)/(V s) at T = 300 K, which increases up to similar to 350 cm(2)/(V s) at 2 K. Semiconducting behavior is observed at low electron densities n, but at high values of n the resistivity decreases by a factor of >7 upon cooling to 2 K and displays a metallic T-2-dependence. This suggests that the band structure of 1T'-ReS2 is quite susceptible to an electric field applied perpendicularly to the layers. The electric-field induced metallic state observed in transition metal dichalcogenides was recently claimed to result from a percolation type of transition. Instead, through a scaling analysis of the conductivity as a function of T and n, we find that the metallic state of ReS2 results from a second-order metal-to-insulator transition driven by electronic correlations. This gate-induced metallic state offers an alternative to phase engineering for producing ohmic contacts and metallic interconnects in devices based on transition metal dichalcogenides. C1 [Pradhan, Nihar R.; Rhodes, Daniel; Lu, Zhengguang; Manousakis, Efstratios; Smirnov, Dmitry; Dobrosavljevic, Vladimir; Balicas, Luis] Florida State Univ, Natl High Magnet Field Lab, Tallahassee, FL 32310 USA. [McCreary, Amber; Feng, Simin; Terrones, Mauricio] Penn State Univ, Dept Phys, State Coll, PA 16802 USA. [McCreary, Amber; Feng, Simin; Terrones, Mauricio] Penn State Univ, Ctr Dimens & Layered Mat 2, State Coll, PA 16802 USA. [McCreary, Amber; Namburu, Raju] US Army, Res Lab, Computat & Informat Sci Directorate, Adelphi, MD 20783 USA. [McCreary, Amber; Dubey, Madan] US Army, Res Lab, Sensor & Electron Devices Directorate, Adelphi, MD 20783 USA. [Rhodes, Daniel; Lu, Zhengguang; Manousakis, Efstratios; Dobrosavljevic, Vladimir] Florida State Univ, Dept Phys, Tallahassee, FL 32306 USA. [Walker, Angela R. Hight] NIST, Div Engn Phys, Phys Lab, Gaithersburg, MD 20899 USA. [Terrones, Humberto] Rensselaer Polytech Inst, Dept Phys Appl Phys & Astron, Troy, NY 12180 USA. [Terrones, Mauricio] Penn State Univ, Dept Chem, State Coll, PA 16802 USA. [Terrones, Mauricio] Penn State Univ, Dept Mat Sci & Engn, State Coll, PA 16802 USA. [Terrones, Mauricio] Shinshu Univ, Carbon Inst Sci & Technol, Nagano 3808553, Japan. RP Balicas, L (reprint author), Florida State Univ, Natl High Magnet Field Lab, 1800 East Paul Dirac Dr, Tallahassee, FL 32310 USA. EM balicas@magnet.fsu.edu FU U.S. Army Research Office MURI [W911NF-11-1-0362]; NHMFL UCGP [5087]; DOE BES Division [DE-FG02-07ER46451]; NSF [NSF-DMR-0084173, DMR-1410132]; State of Florida; National Science Foundation [EFRI-1433311]; US Army Research Laboratory (ARL) Director's Strategic Initiative (DSI) FX This work was supported by the U.S. Army Research Office MURI Grant No. W911NF-11-1-0362. J.L. acknowledges the support by NHMFL UCGP No. 5087. Z.L. and D.S. acknowledge the support by DOE BES Division under Grant No. DE-FG02-07ER46451. The NHMFL is supported by NSF through NSF-DMR-0084173 and the State of Florida. H.T. acknowledges the support from the National Science Foundation (EFRI-1433311). A.M., R.R.N., and M.D. acknowledge the support from the US Army Research Laboratory (ARL) Director's Strategic Initiative (DSI) program on interfaces in stacked 2D atomic layered materials. V.D. is supported by the NSF through Grant No. DMR-1410132. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 42 TC 11 Z9 11 U1 24 U2 130 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1530-6984 EI 1530-6992 J9 NANO LETT JI Nano Lett. PD DEC PY 2015 VL 15 IS 12 BP 8377 EP 8384 DI 10.1021/acs.nanolett.5b04100 PG 8 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA CY3WC UT WOS:000366339600091 PM 26599563 ER PT J AU Hill, KK Xie, G Foley, BT Smith, TJ AF Hill, K. K. Xie, G. Foley, B. T. Smith, T. J. TI Genetic diversity within the botulinum neurotoxin-producing bacteria and their neurotoxins SO TOXICON LA English DT Article; Proceedings Paper CT TOXINS 2015 Basic Science and Clinical Aspects of Botulinum and Other Neurotoxins CY JAN 14-17, 2015 CL Lisbon, PORTUGAL SP Intl Neurotoxin Assoc (INA) DE Genetic diversity; Botulinum neurotoxin; Clostridium botulinum ID II CLOSTRIDIUM-BOTULINUM; C-NEUROTOXIN; E STRAINS; CLUSTER; ORGANIZATION; SEQUENCES; COMPLEX AB The recent availability of multiple Clostridium botulinum genomic sequences has initiated a new genomics era that strengthens our understanding of the bacterial species that produce botulinum neurotoxins (BoNTs). Analysis of the genomes has reinforced the historical Group I-VI designations and provided evidence that the bont genes can be located within the chromosome, phage or plasmids. The sequences provide the opportunity to examine closely the variation among the toxin genes, the composition and organization of the toxin complex, the regions flanking the toxin complex and the location of the toxin within different bacterial strains. These comparisons provide evidence of horizontal gene transfer and site-specific insertion and recombination events that have contributed to the variation observed among the neurotoxins. Here, examples that have contributed to the variation observed in serotypes A-H strains are presented to illustrate the mechanisms that have contributed to their variation. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Hill, K. K.; Xie, G.] Los Alamos Natl Lab, Biosci Div, Los Alamos, NM 87545 USA. [Foley, B. T.] Los Alamos Natl Lab, Div Theoret, Los Alamos, NM 87545 USA. [Smith, T. J.] US Army, Med Res Inst Infect Dis, Mol & Translat Sci Div, Ft Detrick, MD 21702 USA. RP Hill, KK (reprint author), Los Alamos Natl Lab, Biosci Div, MS M88, Los Alamos, NM 87545 USA. EM khill@lanl.gov OI Foley, Brian/0000-0002-1086-0296; xie, gary/0000-0002-9176-924X FU NIH/NIAID [U01 AI056493] FX This research was partially funded by a grant from NIH/NIAID U01 AI056493. The opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army. NR 31 TC 8 Z9 8 U1 2 U2 11 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0041-0101 J9 TOXICON JI Toxicon PD DEC 1 PY 2015 VL 107 SI SI BP 2 EP 8 DI 10.1016/j.toxicon.2015.09.011 PN A PG 7 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA CY6SP UT WOS:000366539400002 PM 26368006 ER PT J AU Reinard, KA Pabaney, AH Basheer, A Phillips, SB Kole, MK Malik, GM AF Reinard, Kevin A. Pabaney, Aqueel H. Basheer, Azam Phillips, Scott B. Kole, Max K. Malik, Ghaus M. TI Surgical Management of Giant Intracranial Arteriovenous Malformations: A Single Center Experience over 32 years SO WORLD NEUROSURGERY LA English DT Article DE Embolization; Giant intracranial arteriovenous malformations (gAVMs); Hemorrhage; Management; Microsurgery ID LINEAR-ACCELERATOR RADIOSURGERY; MARTIN GRADE-IV; TERM-FOLLOW-UP; NATURAL-HISTORY; STEREOTACTIC RADIOSURGERY; MULTIMODALITY TREATMENT; MICROSURGICAL TREATMENT; TREATMENT PARADIGM; STROKE TRIALS; BRAIN AB OBJECTIVE: Treatment of giant intracranial arteriovenous malformations (gAVMs) is a formidable challenge for neurosurgeons and carries significant morbidity and mortality rates for patients compared with smaller AVMs. In this study, we reviewed the treatments, angiographic results, and clinical outcomes in 64 patients with gAVMs who were treated at Henry Ford Hospital between 1980 and 2012. METHODS: The arteriovenous malformation (AVM) database at our institution was queried for patients with gAVMs (>= 6 cm) and data regarding patient demographics, presentation, AVM angioarchitecture, and treatments were collected. Functional outcomes as well as complications were analyzed. RESULTS: Of the 64 patients, 33 (51.6%) were female and 31 (48.4%) were male, with an average age of 45.7 years (SD +/- 15.5). The most common symptoms on presentation were headaches (50%), seizures (50%), and hemorrhage (41%). The mean AVM size was 6.65 cm (range, 6-9 cm). Only 6 AVMs (9.4%) were located in the posterior fossa. The most common Spetzler-Martin grade was V, seen in 64% of patients. Of the 64 patients, 42 (66%) underwent surgical excision, 10 (15.5%) declined any treatment, 8 (12.5%) were deemed inoperable and followed conservatively, 2 (3%) had stand-alone embolization, 1 (1.5%) had embolization before stereotactic radiosurgery, and 1 (1.5%) received stereotactic radiosurgery only. Complete obliteration was achieved in 90% of the surgical patients. Mortality rate was 19% in the surgical cohort compared with 22% in the observation cohort (P = 0.770). CONCLUSIONS: Treatment of gAVMs carries significant morbidity and mortality; however, good outcomes are attainable with a multimodal treatment approach in carefully selected patients. C1 [Reinard, Kevin A.; Pabaney, Aqueel H.; Basheer, Azam; Kole, Max K.; Malik, Ghaus M.] Henry Ford Hosp, Dept Neurosurg, Detroit, MI 48202 USA. [Phillips, Scott B.] Brooke Army Med Ctr, Div Neurol Surg, San Antonio, TX USA. RP Pabaney, AH (reprint author), Henry Ford Hosp, Dept Neurosurg, Detroit, MI 48202 USA. EM apabane1@hfhs.org NR 68 TC 1 Z9 1 U1 1 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1878-8750 EI 1878-8769 J9 WORLD NEUROSURG JI World Neurosurg. PD DEC PY 2015 VL 84 IS 6 BP 1765 EP 1778 DI 10.1016/j.wneu.2015.07.051 PG 14 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA CY3CQ UT WOS:000366286300052 PM 26232210 ER PT J AU Stewart, IJ Sosnov, JA Howard, JT Orman, JA Fang, R Morrow, BD Zonies, DH Bollinger, M Tuman, C Freedman, BA Chung, KK AF Stewart, Ian J. Sosnov, Jonathan A. Howard, Jeffrey T. Orman, Jean A. Fang, Raymond Morrow, Benjamin D. Zonies, David H. Bollinger, Mary Tuman, Caroline Freedman, Brett A. Chung, Kevin K. TI Retrospective Analysis of Long-Term Outcomes After Combat Injury A Hidden Cost of War SO CIRCULATION LA English DT Article DE coronary disease; diabetes mellitus; hypertension; kidney; mortality ID POSTTRAUMATIC-STRESS-DISORDER; CHRONIC KIDNEY-DISEASE; VA HEALTH-CARE; MILITARY SERVICE; COMPETING RISK; PREVALENCE; SEVERITY; SYSTEM; AKI; HYPERTENSION AB Background During the conflicts in Iraq and Afghanistan, 52087 service members have been wounded in combat. The long-term sequelae of these injuries have not been carefully examined. We sought to determine the relation between markers of injury severity and the subsequent development of hypertension, coronary artery disease, diabetes mellitus, and chronic kidney disease. Methods and Results Retrospective cohort study of critically injured US military personnel wounded in Iraq or Afghanistan from February 1, 2002 to February 1, 2011. Patients were then followed until January 18, 2013. Chronic disease outcomes were assessed by International Classification of Diseases, 9th edition codes and causes of death were confirmed by autopsy. From 6011 admissions, records were excluded because of missing data or if they were for an individual's second admission. Patients with a disease diagnosis of interest before the injury date were also excluded, yielding a cohort of 3846 subjects for analysis. After adjustment for other factors, each 5-point increment in the injury severity score was associated with a 6%, 13%, 13%, and 15% increase in incidence rates of hypertension, coronary artery disease, diabetes mellitus, and chronic kidney disease, respectively. Acute kidney injury was associated with a 66% increase in rates of hypertension and nearly 5-fold increase in rates of chronic kidney disease. Conclusions In Iraq and Afghanistan veterans, the severity of combat injury was associated with the subsequent development of hypertension, coronary artery disease, diabetes mellitus, and chronic kidney disease. C1 [Stewart, Ian J.] David Grant Med Ctr, Travis Afb, CA 94535 USA. [Stewart, Ian J.; Sosnov, Jonathan A.; Morrow, Benjamin D.; Chung, Kevin K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Sosnov, Jonathan A.; Morrow, Benjamin D.] San Antonio Mil Med Ctr, San Antonio, TX USA. [Howard, Jeffrey T.; Orman, Jean A.; Chung, Kevin K.] US Army Inst Surg Res, San Antonio, TX USA. [Fang, Raymond] US Air Force Ctr Sustainment Trauma & Readiness S, Baltimore, MD USA. [Zonies, David H.] Oregon Hlth & Sci Univ, Portland, OR 97201 USA. [Bollinger, Mary] South Texas Vet Hlth Care Syst, San Antonio, TX USA. [Tuman, Caroline; Freedman, Brett A.] Landstuhl Reg Med Ctr, Landstuhl, Germany. RP Stewart, IJ (reprint author), David Grant Med Ctr, Clin Invest Facil, 101 Bodin Circle, Travis Afb, CA 94535 USA. EM ian.stewart@us.af.mil FU Oak Ridge Institute of Science and Education FX This study was funded in part by a postdoctoral fellowship provided by the Oak Ridge Institute of Science and Education. NR 39 TC 3 Z9 3 U1 1 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0009-7322 EI 1524-4539 J9 CIRCULATION JI Circulation PD DEC 1 PY 2015 VL 132 IS 22 BP 2126 EP 2133 DI 10.1161/CIRCULATIONAHA.115.016950 PG 8 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA CY1SE UT WOS:000366187100005 PM 26621637 ER PT J AU Anisowicz, SK Abadie, JM AF Anisowicz, Sarah K. Abadie, Jude M. TI Six-Month-Old Boy with "Milky" Serum SO CLINICAL CHEMISTRY LA English DT Editorial Material ID HYPERTRIGLYCERIDEMIA C1 [Anisowicz, Sarah K.] Tripler Army Med Ctr, Dept Pediat, Honolulu, HI 96859 USA. [Abadie, Jude M.] Tripler Army Med Ctr, Dept Pathol, Honolulu, HI 96859 USA. RP Anisowicz, SK (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd,MCHK PE, Honolulu, HI 96859 USA. EM sarah.k.anisowicz.mil@mail.mil NR 9 TC 1 Z9 1 U1 0 U2 1 PU AMER ASSOC CLINICAL CHEMISTRY PI WASHINGTON PA 2101 L STREET NW, SUITE 202, WASHINGTON, DC 20037-1526 USA SN 0009-9147 EI 1530-8561 J9 CLIN CHEM JI Clin. Chem. PD DEC PY 2015 VL 61 IS 12 BP 1441 EP 1443 DI 10.1373/clinchem.2014.235143 PG 3 WC Medical Laboratory Technology SC Medical Laboratory Technology GA CY0BT UT WOS:000366071900004 PM 26614227 ER PT J AU Tahmoush, D Ling, H Stankovic, L Thayaparan, T Narayanan, R AF Tahmoush, David Ling, Hao Stankovic, Ljubisa Thayaparan, Thayananthan Narayanan, Ram TI Current Research in Micro-Doppler: Editorial for the Special Issue on Micro-Doppler SO IET RADAR SONAR AND NAVIGATION LA English DT Editorial Material DE digital signatures; electric sensing devices; Doppler effect; feature extraction; micro-Doppler technique; micro-Doppler signature identification; micromotion; active emitter; micro-Doppler capable sensor; salient feature extraction ID CLASSIFICATION; DECOMPOSITION; SIGNATURES C1 [Tahmoush, David] US Army Res Lab, Adelphi, MD 20783 USA. [Ling, Hao] Univ Texas Austin, Elect & Comp Engn, Austin, TX 78712 USA. [Stankovic, Ljubisa] Univ Montenegro, Podgorica, Montenegro. [Thayaparan, Thayananthan] Univ Western Ontario, London, ON N6A 3K7, Canada. [Thayaparan, Thayananthan] Def Res & Dev Canada, Ottawa, ON, Canada. [Thayaparan, Thayananthan] McMaster Univ, Hamilton, ON L8S 4L8, Canada. [Narayanan, Ram] Penn State Univ, Elect Engn, University Pk, PA 16802 USA. RP Tahmoush, D (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. NR 35 TC 0 Z9 0 U1 2 U2 6 PU INST ENGINEERING TECHNOLOGY-IET PI HERTFORD PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD SG1 2AY, ENGLAND SN 1751-8784 EI 1751-8792 J9 IET RADAR SONAR NAV JI IET Radar Sonar Navig. PD DEC PY 2015 VL 9 IS 9 SI SI BP 1137 EP 1139 DI 10.1049/iet-rsn.2015.0547 PG 3 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA CX7BK UT WOS:000365855500001 ER PT J AU Tahmoush, D AF Tahmoush, Dave TI Review of micro-Doppler signatures SO IET RADAR SONAR AND NAVIGATION LA English DT Review DE Doppler radar; radar signal processing; helicopters; autonomous aerial vehicles; micro-Doppler signatures; micro-Doppler signals; kinematic properties; salient feature extraction; micro-Doppler-capable active sensors; fixed-wing aircraft; multiple spinning rotor blades; helicopter; unmanned aerial vehicle; confuser detections ID EMPIRICAL-MODE DECOMPOSITION; BISTATIC SEA CLUTTER; RADAR SIGNATURES; ROTATING PARTS; TIME-FREQUENCY; PERSONNEL TARGETS; RIGID TARGETS; LOW-COST; CLASSIFICATION; MICROMOTION AB Micro-Doppler signals refer to Doppler scattering returns produced by the motions of the target other than gross translation. The small micro-motions of a subject, and even just parts of a subject, can be observed through the micro-Doppler signature it creates in response to an active emitter such as a radar, laser, and even acoustic emitters. These micro-Doppler signatures are produced by the kinematic properties of the subject's motion and can be used to extract the salient features of the subject's motion, and often, identify the subject. The rapidly declining cost of micro-Doppler-capable active sensors like radar with their dramatically improving capabilities, provide significant motivation in developing micro-Doppler techniques that can improve the exploitation of these sensors. Micro-Doppler techniques aim at extracting the micro-motion of the subject that may be unique to a particular subject class or activity in order to distinguish probable false alarms from real detections, as well as to increase the value of the information extracted from the sensor. The source of micro-motion depends on the subject and can be a rotating propeller on a fixed-wing aircraft, the multiple spinning rotor blades of a helicopter, or an unmanned aerial vehicle (UAV); the vibrations of an engine shaking a vehicle; an antenna rotating on a ship; the flapping wings of birds; the swinging arms and legs of a walking person; and many other sources. Confuser detections, such as birds for UAVs or animals for humans, can be interpreted as false alarms for a sensor system, so using the available micro-Doppler returns for classification can significantly reduce the sensor false alarm rate, thereby improving the utility of the sensor system. This study reviews the current research in micro-Doppler based on subject type, sensor capabilities, as well as environmental effects, and then proposes future research areas for micro-Doppler. C1 [Tahmoush, Dave] US Army Res Lab, Adelphi, MD 20783 USA. RP Tahmoush, D (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM david.tahmoush.civ@mail.mil NR 143 TC 9 Z9 10 U1 5 U2 24 PU INST ENGINEERING TECHNOLOGY-IET PI HERTFORD PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD SG1 2AY, ENGLAND SN 1751-8784 EI 1751-8792 J9 IET RADAR SONAR NAV JI IET Radar Sonar Navig. PD DEC PY 2015 VL 9 IS 9 SI SI BP 1140 EP 1146 DI 10.1049/iet-rsn.2015.0118 PG 7 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA CX7BK UT WOS:000365855500002 ER PT J AU Peachman, KK Karasavvas, N Chenine, AL McLinden, R Rerks-Ngarm, S Jaranit, K Nitayaphan, S Pitisuttithum, P Tovanabutra, S Zolla-Pazner, S Michael, NL Kim, JH Alving, CR Rao, M AF Peachman, Kristina K. Karasavvas, Nicos Chenine, Agnes-Laurence McLinden, Robert Rerks-Ngarm, Supachai Jaranit, Kaewkungwal Nitayaphan, Sorachai Pitisuttithum, Punnee Tovanabutra, Sodsai Zolla-Pazner, Susan Michael, Nelson L. Kim, Jerome H. Alving, Carl R. Rao, Mangala TI Identification of New Regions in HIV-1 gp120 Variable 2 and 3 Loops that Bind to alpha 4 beta 7 Integrin Receptor SO PLOS ONE LA English DT Article ID IMMUNODEFICIENCY-VIRUS TYPE-1; CD4(+) T-CELLS; ENVELOPE GLYCOPROTEIN; MONOCLONAL-ANTIBODY; VACCINE EFFICACY; MUCOSAL TRANSMISSION; INFECTION; ALPHA(4)BETA(7); V2; NEUTRALIZATION AB Background The gut mucosal homing integrin receptor alpha 4 beta 7 present on activated CD4(+) T cells interacts with the HIV-1 gp120 second variable loop (V2). Case control analysis of the RV144 phase III vaccine trial demonstrated that plasma IgG binding antibodies specific to scaffolded proteins expressing the first and second variable regions (V1V2) of HIV envelope protein gp120 containing the alpha 4 beta 7 binding motif correlated inversely with risk of infection. Subsequently antibodies to the V3 region were also shown to correlate with protection. The integrin receptor alpha 4 beta 7 was shown to interact with the LDI/V motif on V2 loop but recent studies suggest that additional regions of V2 loop could interact with the alpha 4 beta 7. Thus, there may be several regions on the V2 and possibly V3 loops that may be involved in this binding. Using a cell line, that constitutively expressed alpha 4 beta 7 receptors but lacked CD4, we examined the contribution of V2 and V3 loops and the ability of V2 peptide-, V2 integrin-, V3-specific monoclonal antibodies (mAbs), and purified IgG from RV144 vaccinees to block the V2/V3-alpha 4 beta 7 interaction. Results We demonstrate that alpha 4 beta 7 on RPMI8866 cells bound specifically to its natural ligand mucosal addressin cell adhesion molecule-1 (MAdCAM-1) as well as to cyclic-V2 and cyclic-V3 peptides. This binding was inhibited by anti-alpha 4 beta 7-specific monoclonal antibody (mAb) ACT-1, mAbs specific to either V2 or V3 loops, and by purified primary virions or infectious molecular clones expressing envelopes from acute or chronic subtypes A, C, and CRF01_AE viruses. Plasma from HIV-1 infected Thai individuals as well as purified IgG from uninfected RV144 vaccinees inhibited (0-50%) the binding of V2 and V3 peptides to alpha 4 beta 7. Conclusion Our results indicate that in addition to the tripeptide LDI/V motif, other regions of the V2 and V3 loops of gp120 were involved in binding to alpha 4 beta 7 receptors and this interaction was blocked by anti-V2 peptide, anti-V2 integrin, and anti-V3 antibodies. The ability of purified IgG from some of the uninfected RV144 vaccinees to inhibit alpha 4 beta 7 raises the hypothesis that anti-V2 and anti-V3 antibodies may play a role in blocking the gp120-alpha 4 beta 7 interaction after vaccination and thus prevent HIV-1 acquisition. C1 [Peachman, Kristina K.; Chenine, Agnes-Laurence; McLinden, Robert; Tovanabutra, Sodsai; Michael, Nelson L.; Kim, Jerome H.; Alving, Carl R.; Rao, Mangala] US Mil HIV Res Program, Walter Reed Army Inst Res, Silver Spring, MD USA. [Peachman, Kristina K.; Chenine, Agnes-Laurence; McLinden, Robert; Tovanabutra, Sodsai] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Karasavvas, Nicos] US Army Med Component, Armed Forces Res Inst Med Sci, Bangkok, Thailand. [Rerks-Ngarm, Supachai] Minist Publ Hlth, Bangkok, Thailand. [Jaranit, Kaewkungwal] Mahidol Univ, Data Management Unit, Bangkok 10700, Thailand. [Nitayaphan, Sorachai] Armed Forces Res Inst Med Sci, Royal Thai Army, Bangkok 10400, Thailand. [Pitisuttithum, Punnee] Mahidol Univ, Vaccine Trials Ctr, Bangkok 10700, Thailand. [Zolla-Pazner, Susan] Vet Adm New York Harbor Hlth Care Syst, Sch Med, New York, NY USA. [Zolla-Pazner, Susan] NYU, Sch Med, New York, NY USA. RP Rao, M (reprint author), US Mil HIV Res Program, Walter Reed Army Inst Res, Silver Spring, MD USA. EM mrao@hivresearch.org FU Henry M. Jackson Foundation [W81XWH-11-2-0174]; US Department of Defense [W81XWH-11-2-0174]; National Institutes of Allergy and Infectious Diseases [AI 100151]; Department of Veterans Affairs FX This work was supported by a cooperative agreement (W81XWH-11-2-0174) between the Henry M. Jackson Foundation and the US Department of Defense. SZ-P is supported by a grant from the National Institutes of Allergy and Infectious Diseases (AI 100151) and by funds from the Department of Veterans Affairs. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 69 TC 2 Z9 2 U1 1 U2 10 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 1 PY 2015 VL 10 IS 12 AR e0143895 DI 10.1371/journal.pone.0143895 PG 25 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CX7OL UT WOS:000365891600071 PM 26625359 ER PT J AU Rosenstein, JE Carroll, MH AF Rosenstein, Judith E. Carroll, Marjorie H. TI Male Rape Myths, Female Rape Myths, and Intent to Intervene as a Bystander SO VIOLENCE AND GENDER LA English DT Article ID SEXUAL VIOLENCE; COLLEGE-STUDENTS; GENDER; PREVENTION; ACCEPTANCE; BEHAVIOR; SEXISM; VICTIM; MODEL; HELP AB The bystander approach to sexual assault prevention has become popular on college campuses and within the military. Previous research has identified a negative association between the acceptance of rape myths and the likelihood of individuals intervening in a sexual assault situation. However, to date, all examinations of rape myth acceptance (RMA) and bystander intervention have focused on female rape myths (i.e., myths about rape involving a female victim). The current study explored whether male RMA (i.e., acceptance of myths about rape involving a male victim) influences bystander intervention in similar or differing ways compared with female RMA. In addition, the study explored whether male and female RMA function differently by subtypes of bystander intervention (i.e., known victim vs. stranger victim) and bystander gender. Participants included 970 students (731 men, 239 women) entering the United States Naval Academy. Participants completed the Illinois Rape Myth Acceptance ScaleShort Form, a 30-item male RMA scale, and the Intent to Help Friends and Intent to Help Strangers scales. The findings indicated that higher acceptance of both female and male rape myths was associated with a lowered intent to help someone known to the bystander. In contrast, after controlling for both types of RMA, only male RMA had a negative relationship with intent to help a stranger. These findings highlight the need to incorporate a discussion of male victimization and associated myths into bystander intervention programs. C1 [Rosenstein, Judith E.] US Naval Acad, Dept Leadership Eth & Law, Annapolis, MD 21401 USA. [Carroll, Marjorie H.] US Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA. RP Rosenstein, JE (reprint author), US Naval Acad, Dept Leadership Eth & Law, 112 Cooper Rd,Stop 7B, Annapolis, MD 21401 USA. EM rosenste@usna.edu NR 30 TC 1 Z9 1 U1 6 U2 33 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 2326-7836 EI 2326-7852 J9 VIOLENCE GEND JI Violence Gend. PD DEC 1 PY 2015 VL 2 IS 4 BP 204 EP 208 DI 10.1089/vio.2015.0027 PG 5 WC Criminology & Penology SC Criminology & Penology GA CY3LE UT WOS:000366310200004 ER PT J AU Copeland, AM Van Deusen, NM Schmaljohn, CS AF Copeland, Anna Maria Van Deusen, Nicole M. Schmaljohn, Connie S. TI Rift Valley fever virus NSS gene expression correlates with a defect in nuclear mRNA export SO VIROLOGY LA English DT Article DE mRNA; Rift Valley fever virus; NSS; RNA export; PABP1 ID VESICULAR STOMATITIS-VIRUS; INFECTED-CELLS; BINDING-PROTEIN; MATRIX PROTEIN; SEGMENT; TRANSCRIPTION; INHIBITION; SEQUENCES; P62 AB We investigated the localization of host mRNA during Rift Valley fever virus (RVFV) infection. Fluorescence in situ hybridization revealed that infection with RVFV altered the localization of host mRNA. mRNA accumulated in the nuclei of RVFV-infected but not mock-infected cells. Further, overexpression of the NSs gene, but not the N, G(N) or NSM genes correlated with mRNA nuclear accumulation. Nuclear accumulation of host mRNA was not observed in cells infected with a strain of RVFV lacking the gene encoding NSs, confirming that expression of NSs is likely responsible for this phenomenon. Published by Elsevier Inc. C1 [Copeland, Anna Maria; Van Deusen, Nicole M.; Schmaljohn, Connie S.] US Army Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Schmaljohn, CS (reprint author), US Army Med Res Inst Infect Dis, 1425 Porter St, Frederick, MD 21702 USA. EM Connie.s.schmaljohn.civ@mail.mil FU Joint Sciences and Technology Office of the US Defense Threat Reduction Agency FX The authors wish to thank Stuart Nichol (Centers for Disease Control), Julie Costantino (USAMRIID), Sheli Radoshitzlcy (USAMRIID), Sina Bavari (USAMRIID), and Robert Dams (University of Pennsylvania) for generous gifts of plasmids and Shinji Makino (University of Texas Medical Branch) for providing the MP12rLuc virus. We also wish to thank Neal Satterly for useful discussions of results. The research was performed while Anna Maria Copeland held a National Academy of Sciences National Research Council Associateship, which was funded by the Joint Sciences and Technology Office of the US Defense Threat Reduction Agency. Opinions, interpretations, conclusions, and recommendations are ours and are not necessarily endorsed by the U.S. Army or Department of Defense. NR 28 TC 2 Z9 2 U1 2 U2 3 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD DEC PY 2015 VL 486 BP 88 EP 93 DI 10.1016/j.virol.2015.09.003 PG 6 WC Virology SC Virology GA CY2HQ UT WOS:000366229800013 PM 26410240 ER PT J AU Knox, RW Demons, ST Cunningham, CW AF Knox, Randy W. Demons, Samandra T. Cunningham, Cord W. TI A Novel Method to Decontaminate Surgical Instruments for Operational and Austere Environments SO WILDERNESS & ENVIRONMENTAL MEDICINE LA English DT Article DE austere; operational; emergency; life-saving interventions; field equipment sterilization ID RADIATION; CARE AB Objective.-The purpose of this investigation was to test a field-expedient, cost-effective method to decontaminate, sterilize, and package surgical instruments in an operational (combat) or austere environment using chlorhexidine sponges, ultraviolet C (UVC) light, and commercially available vacuum sealing. Methods.-This was a bench study of 4 experimental groups and 1 control group of 120 surgical instruments. Experimental groups were inoculated with a 106 concentration of common wound bacteria. The control group was vacuum sealed without inoculum. Groups 1, 2, and 3 were first scrubbed with a chlorhexidine sponge, rinsed, and dried. Group 1 was then packaged; group 2 was irradiated with UVC light, then packaged; group 3 was packaged, then irradiated with UVC light through the bag; and group 4 was packaged without chlorhexidine scrubbing or UVC irradiation. The UVC was not tested by itself, as it does not grossly clean. The instruments were stored overnight and tested for remaining colony forming units (CFU). Results.-Data analysis was conducted using analysis of variance and group comparisons using the Tukey method. Group 4 CFU was statistically greater (P<.001) than the control group and groups 1 through 3. There was no statistically significant difference between the control group and groups 1 through 3. Conclusions.-Vacuum sealing of chlorhexidine-scrubbed contaminated instruments with and without handheld UVC irradiation appears to be an acceptable method of field decontamination. Chlorhexidine scrubbing alone achieved a 99.9% reduction in CFU, whereas adding UVC before packaging achieved sterilization or 100% reduction in CFU, and UVC through the bag achieved disinfection. C1 [Knox, Randy W.] William Beaumont Army Med Ctr, Emergency Med Physician Assistant Residency, Ft Bliss, TX USA. [Knox, Randy W.] William Beaumont Army Med Ctr, Dept Emergency Med, Ft Bliss, TX USA. [Demons, Samandra T.] United States Army Med Res Inst Infect Dis, Ft Detrick, MD USA. [Cunningham, Cord W.] San Antonio Mil Med Ctr, EMS & Disaster Med Fellowship, Joint Base San Antonio, TX USA. [Cunningham, Cord W.] San Antonio Mil Med Ctr, Dept Emergency Med, Joint Base San Antonio, TX 78234 USA. RP Cunningham, CW (reprint author), San Antonio Mil Med Ctr, Dept Emergency Med, Bldg 3851,Roger Brooke Dr, Joint Base San Antonio, TX 78234 USA. EM c4.cunningham@gmail.com NR 5 TC 0 Z9 0 U1 2 U2 7 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1080-6032 EI 1545-1534 J9 WILD ENVIRON MED JI Wildern. Environ. Med. PD DEC PY 2015 VL 26 IS 4 BP 509 EP 513 PG 5 WC Public, Environmental & Occupational Health; Sport Sciences SC Public, Environmental & Occupational Health; Sport Sciences GA CY2HA UT WOS:000366228200008 PM 26165581 ER PT J AU Pidcoke, HF Cap, AP AF Pidcoke, Heather F. Cap, Andrew P. TI Refrigerated Platelets for the Treatment of Acute Bleeding: A Review of the Literature and Reexamination of Current Standards: Reply SO SHOCK LA English DT Letter C1 [Pidcoke, Heather F.; Cap, Andrew P.] US Army Inst Surg Res, JBSA Ft Sam Houston, San Antonio, TX 78234 USA. RP Pidcoke, HF (reprint author), US Army Inst Surg Res, JBSA Ft Sam Houston, San Antonio, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD DEC PY 2015 VL 44 IS 6 BP 616 EP 617 PG 2 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA CX4LZ UT WOS:000365673700016 PM 26565705 ER PT J AU Recchia, S Zheng, JQ Horner, S Pelegri, AA AF Recchia, Stephen Zheng, James Q. Horner, Suzanne Pelegri, Assimina A. TI Multiscale modeling of randomly interwoven fibers for prediction of KM2 Kevlar yarn strength and damage SO ACTA MECHANICA LA English DT Article ID REPRESENTATIVE VOLUME ELEMENT; COMPOSITES AB Modeling Kevlar yarn response as a function of twist requires creating a model at the filament level that incorporates capturing the mechanical interaction of numerous fibers. The inherent complexity of building a multiscale interwoven fibrous structure manually is prohibitive for such an endeavor; therefore, computer-aided simulations are preferred. In this study, a random walk methodology was employed to generate a fibrous structure along the axis of a yarn. Since the directionality of the fibers is randomly oriented along the axis, the fibers can wind around each other and tangle or terminate on demand. The resultant geometry can represent the tortuous path that yarn filaments experience. Yarn twist can be introduced through imposing a rotation matrix to the geometry or conducting an initial analysis that applies the preload. The analysis method employed in this paper captures the correct prestress of the twisted yarns at zero, three, and ten twists per inch. The analysis then loaded the yarn until filament fracture occurred. The predicted ultimate load was within 5% for all three twists per inch analyzed. The zero twists per inch linear response matched test results to within 5%. C1 [Recchia, Stephen] Rutgers State Univ, Sch Engn, Adv Mat & Struct Lab, Piscataway, NJ 08854 USA. [Zheng, James Q.; Horner, Suzanne] US Army, Program Execut Off Soldier, Ft Belvoir, VA 22060 USA. [Pelegri, Assimina A.] Rutgers State Univ, Sch Engn, Dept Mech & Aerosp Engn, Piscataway, NJ 08854 USA. RP Pelegri, AA (reprint author), Rutgers State Univ, Sch Engn, Dept Mech & Aerosp Engn, 98 Brett Rd, Piscataway, NJ 08854 USA. EM pelegri@jove.rutgers.edu FU United States Army [W91CRB-12-P-0047 P00003] FX The authors kindly acknowledge the financial support PEO-Soldier of the United States Army Contract W91CRB-12-P-0047 P00003 to perform this research. NR 26 TC 1 Z9 1 U1 3 U2 9 PU SPRINGER WIEN PI WIEN PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA SN 0001-5970 EI 1619-6937 J9 ACTA MECH JI Acta Mech. PD DEC PY 2015 VL 226 IS 12 BP 4149 EP 4158 DI 10.1007/s00707-015-1486-0 PG 10 WC Mechanics SC Mechanics GA CX2GB UT WOS:000365513500015 ER PT J AU Walsh, DV Jurek, GM Capo-Aponte, JE Riggs, DW Ramiccio, JA AF Walsh, David V. Jurek, Gina M. Capo-Aponte, Jose E. Riggs, Daniel W. Ramiccio, John A. TI Assessment of an Alternative Army Aircrew Eyewear SO AEROSPACE MEDICINE AND HUMAN PERFORMANCE LA English DT Article DE aviator spectacles; aircrew flight frame operational style; military; vision correction AB BACKGROUND: Currently, Army aircrews needing refractive correction are issued the HGU-4/P aviator spectacles. However, a recently published survey found dissatisfaction with the current spectacle frame. The Aircrew Flight Frame (AFF) has been used by the Air Force for over 14 yr, with the AFF-OP (Operational) style used the longest. The purpose of this study was to evaluate AFF-OP performance and compatibility among U.S. Army aircrew under operational conditions. METHODS: At 1-, 6-, and 12-wk intervals, 73 Army aircrew members wore the AFF-OP eyewear and completed a Likert scale survey. There were 14 outcome measures surveyed, with the main outcome measure being frame preference. RESULTS: The AFF-OP was preferred significantly more than the HGV-4/P spectacle. Overall, 94% of aircrew responses preferred the AFF-OP and the three highest subjective reasons for AFF-OP preference were: 1) comfort around the ears without helmet or headset; 2) comfort around the ears with helmet or headset; and 3) the effect on ear cup seal. There were no statistically significant differences in responses over the three surveyed time intervals. DISCUSSION: Army aviation aircrew preferred the AFF-OP over the current HGU-4/P spectacles. Two of the top three highest subjective reasons for AFF-OP preference coincided with two of the top three operational eyewear problems reported in the recently published survey. If Army aircrew do not wear their issued eyewear, they may purchase their own frame "out of pocket." However, this can lead to use of a frame that has not been tested for compatibility and may compromise performance of aircrew life support equipment. C1 [Walsh, David V.] US Army Aeromed Res Lab, Ft Rucker, AL 36362 USA. Womack Army Med Ctr, Ft Bragg, NC USA. RP Walsh, DV (reprint author), US Army Aeromed Res Lab, Vis Protect & Performance Div, 6901 Farrel Rd, Ft Rucker, AL 36362 USA. EM david.v.walsh.mil@mail.mil FU Military Operational Medicine Research Program of the U.S. Army Medical Research and Materiel Command FX This research was funded by the Military Operational Medicine Research Program of the U.S. Army Medical Research and Materiel Command. It was sponsored in part by the appointment to the Postgraduate Research Participation Program at the U.S. Army Aeromedical Research Laboratory administered by the Oak Ridge Institute of Science and Education through an interagency agreement the U.S. Department of Energy and U.S. Army Medical Research Material Command. Finally, the authors thank the Naval Ophthalmic Support and Training Activity laboratory for supplying the frames and lenses in support of the research. NR 11 TC 1 Z9 1 U1 0 U2 1 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 2375-6314 EI 2375-6322 J9 AEROSP MED HUM PERF JI Aerosp. Med.Hum. Perform. PD DEC PY 2015 VL 86 IS 12 BP 1014 EP 1019 DI 10.3357/AMHP.4361.2015 PG 6 WC Biophysics; Public, Environmental & Occupational Health; Medicine, Research & Experimental SC Biophysics; Public, Environmental & Occupational Health; Research & Experimental Medicine GA CX6UZ UT WOS:000365838500002 PM 26630047 ER PT J AU Naim, R Abend, R Wald, I Eldar, S Levi, O Fruchter, E Ginat, K Halpern, P Sipos, ML Adler, AB Bliese, PD Quartana, PJ Pine, DS Bar-Haim, Y AF Naim, Reut Abend, Rany Wald, Ilan Eldar, Sharon Levi, Ofir Fruchter, Eyal Ginat, Karen Halpern, Pinchas Sipos, Maurice L. Adler, Amy B. Bliese, Paul D. Quartana, Phillip J. Pine, Daniel S. Bar-Haim, Yair TI Threat-Related Attention Bias Variability and Posttraumatic Stress SO AMERICAN JOURNAL OF PSYCHIATRY LA English DT Article ID ANXIETY DISORDERS; PTSD; AMYGDALA; CHILDREN; METAANALYSIS; SYMPTOMS; FEAR; ADOLESCENTS; SPECIFICITY; DYSFUNCTION AB Objective: Threat monitoring facilitates survival by allowing one to efficiently and accurately detect potential threats. Traumatic events can disrupt healthy threat monitoring, inducing biased and unstable threat-related attention deployment. Recent research suggests that greater attention bias variability, that is, attention fluctuations alternating toward and away from threat, occurs in participants with PTSD relative to healthy comparison subjects who were either exposed or not exposed to traumatic events. The current study extends findings on attention bias variability in PTSD Method: Previous measurement of attention bias variability was refined by employing a moving average technique. Analyses were conducted across seven independent data sets; in each, data on attention bias variability were collected by using variants of the dot-probe task. Trauma-related and anxiety symptoms were evaluated across samples by using structured psychiatric interviews and widely used self-report questionnaires, as specified for each sample. Results: Analyses revealed consistent evidence of greater attention bias variability in patients with PTSD following various types of traumatic events than in healthy participants, participants with social anxiety disorder, and participants with acute stress disorder. Moreover, threat-related, and not positive, attention bias variability was correlated with PTSD severity. Conclusions: These findings carry possibilities for using attention bias variability as a specific cognitive marker of PTSD and for tailoring protocols for attention bias modification for this disorder. C1 [Naim, Reut] Tel Aviv Univ, Sagol Sch Neurosci, Sch Psychol Sci, IL-69978 Tel Aviv, Israel. Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel. Israel Def Forces, Med Corps, Div Mental Hlth, Jerusalem, Israel. Tel Aviv Med Ctr & Sch Med, Emergency Dept, Tel Aviv, Israel. US Army Med Res & Mat Command, Ctr Mil Psychiat & Neurosci, Walter Reed Army Inst Res, Silver Spring, MD USA. Univ S Carolina, Darla Moore Sch Business, Columbia, SC 29208 USA. NIMH, Intramural Res Program, Bethesda, MD 20892 USA. RP Naim, R (reprint author), Tel Aviv Univ, Sagol Sch Neurosci, Sch Psychol Sci, IL-69978 Tel Aviv, Israel. EM reutnaim@post.tau.ac.il NR 50 TC 13 Z9 13 U1 9 U2 25 PU AMER PSYCHIATRIC PUBLISHING, INC PI ARLINGTON PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA SN 0002-953X EI 1535-7228 J9 AM J PSYCHIAT JI Am. J. Psychiat. PD DEC PY 2015 VL 172 IS 12 BP 1242 EP 1250 DI 10.1176/appi.ajp.2015.14121579 PG 9 WC Psychiatry SC Psychiatry GA CX6UJ UT WOS:000365836900012 PM 26206076 ER PT J AU Farooq, F Bergmann-Leitner, ES AF Farooq, Fouzia Bergmann-Leitner, Elke S. TI Immune Escape Mechanisms are Plasmodium's Secret Weapons Foiling the Success of Potent and Persistently Efficacious Malaria Vaccines SO CLINICAL IMMUNOLOGY LA English DT Article DE Malaria; Immune escape; Immune editing; Vaccine ID REGULATORY T-CELLS; FALCIPARUM-INFECTED ERYTHROCYTES; CIRCUMSPOROZOITE PROTEIN; HUMAN VOLUNTEERS; DENDRITIC CELLS; STAGE MALARIA; IN-VIVO; PARASITE; SPOROZOITES; COMPLEMENT AB Despite decades of active research, an efficacious vaccine mediating long-term protection is still not available. This review highlights various mechanisms and the different facets by which the parasites outsmart the immune system. An understanding of how the parasites escape immune recognition and interfere with the induction of a protective immune response that provides sterilizing immunity will be crucial to vaccine design. Published by Elsevier Inc. C1 [Farooq, Fouzia; Bergmann-Leitner, Elke S.] Walter Reed Army Inst Res, Malaria Vaccine Branch, US Mil Malaria Res Program, Silver Spring, MD 20910 USA. RP Bergmann-Leitner, ES (reprint author), Walter Reed Army Inst Res, Malaria Vaccine Branch, US Mil Malaria Res Program, Silver Spring, MD 20910 USA. EM elke.s.bergmannleitner.civ@mail.mil NR 69 TC 2 Z9 2 U1 1 U2 4 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1521-6616 EI 1521-7035 J9 CLIN IMMUNOL JI Clin. Immunol. PD DEC PY 2015 VL 161 IS 2 BP 136 EP 143 DI 10.1016/j.clim.2015.08.015 PG 8 WC Immunology SC Immunology GA CX6SL UT WOS:000365831600011 PM 26342537 ER PT J AU Laxminarayan, S Reifman, J Edwards, SS Wolpert, H Steil, GM AF Laxminarayan, Srinivas Reifman, Jaques Edwards, Stephanie S. Wolpert, Howard Steil, Garry M. TI Bolus Estimation-Rethinking the Effect of Meal Fat Content SO DIABETES TECHNOLOGY & THERAPEUTICS LA English DT Article ID TYPE-1 DIABETES IMPLICATIONS; INCREASES GLUCOSE-CONCENTRATIONS; INSULIN REQUIREMENTS; DOSE CALCULATION; SENSITIVITY; MANAGEMENT; PROTEIN; OUTPUT; PUMP AB Background: Traditionally, insulin bolus calculations for managing postprandial glucose levels in individuals with type 1 diabetes rely solely on the carbohydrate content of a meal. However, recent studies have reported that other macronutrients in a meal can alter the insulin required for good postprandial control. Specifically, studies have shown that high-fat (HF) meals require more insulin than low-fat (LF) meals with identical carbohydrate content. Our objective was to assess the mechanisms underlying the higher insulin requirement observed in one of these studies. Materials and Methods: We used a combination of previously validated metabolic models to fit data from a study comparing HF and LF dinners with identical carbohydrate content in seven subjects with type 1 diabetes. For each subject and dinner type, we estimated the model parameters representing the time of peak meal-glucose appearance ((m)), insulin sensitivity (S-I), the net hepatic glucose balance, and the glucose effect at zero insulin in four time windows (dinner, early night, late night, and breakfast) and assessed the differences in model parameters via paired Wilcoxon signed-rank tests. Results: During the HF meal, the (m) was significantly delayed (mean and standard error [SE]: 102 [14] min vs. 71 [4] min; P=0.02), and S-I was significantly lower (7.25x10(-4) [1.29x10(-4)] mL/U/min vs. 8.72x10(-4) [1.08x10(-4)] mL/U/min; P=0.02). Conclusions: In addition to considering the putative delay in gastric emptying associated with HF meals, we suggest that clinicians reviewing patient records consider that the fat content of these meals may alter S-I. C1 [Laxminarayan, Srinivas; Reifman, Jaques] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Dept Def, Biotechnol High Performance Comp Software Applica, Ft Detrick, MD USA. [Edwards, Stephanie S.; Wolpert, Howard] Joslin Diabet Ctr, Boston, MA 02215 USA. [Wolpert, Howard; Steil, Garry M.] Harvard Univ, Sch Med, Boston, MA USA. [Steil, Garry M.] Childrens Hosp, Boston, MA 02115 USA. RP Steil, GM (reprint author), Childrens Hosp Boston, ATTN Div Med Crit Care, 333 Longwood Ave, Boston, MA 02215 USA. EM garry.steil@childrens.harvard.edu FU U.S. Department of Defense [W81XWH-11-1-0421]; Military Operational Medicine Research Area Directorate of the U.S. Army Medical Research and Materiel Command, Fort Detrick, MD FX The study was supported by U.S. Department of Defense grant W81XWH-11-1-0421 to G.M.S. and by the Military Operational Medicine Research Area Directorate of the U.S. Army Medical Research and Materiel Command, Fort Detrick, MD, to S.L. and J.R. NR 22 TC 4 Z9 4 U1 0 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1520-9156 EI 1557-8593 J9 DIABETES TECHNOL THE JI Diabetes Technol. Ther. PD DEC 1 PY 2015 VL 17 IS 12 BP 860 EP 866 DI 10.1089/dia.2015.0118 PG 7 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA CX4DB UT WOS:000365647500004 PM 26270134 ER PT J AU Adams, BL Stratis-Cullum, DN AF Adams, Bryn L. Stratis-Cullum, Dimitra N. TI Selective preference of engineered peptides for aluminum alloy SO EMERGING MATERIALS RESEARCH LA English DT Article DE biomaterials; biomolecules; hybrid materials and structures ID PHAGE DISPLAY; BINDING PEPTIDE; SPECIFICITY; AFFINITY; SURFACES; IDENTIFICATION; POLYPEPTIDES; RECOGNITION; DESIGN; OXIDE AB Bacterial cell surface display technology offers a powerful tool for the discovery and study of peptide-material interactions offering the potential toward tailoring the interaction and tuning the properties of multicomponent materials for future military and commercial systems. With bacterial cell surface display technology, a large diverse library containing billions of peptide material variants is encoded directly into the bacterial DNA, resulting in a self-sustaining and replicating population that can easily be propagated without requiring elution from the target. Recently, this method was extended to genetically engineered peptides for inorganics: specifically to a bulk aluminum alloy. In this paper, we further investigate the binding interaction of this peptide material including a study of relative binding to aluminum, glass, copper and brass. The surface display peptide exhibited more than 2 order of magnitude greater binding to the aluminum alloy compared to the glass sample, and little to no interaction with copper and brass. These results highlight, for the first time, the potential for selection interaction of genetically engineered peptides using the eCPX construct with inorganic materials and open the possibility for biohybrid materials and systems of the future. C1 [Adams, Bryn L.; Stratis-Cullum, Dimitra N.] US Army Res Lab, Adelphi, MD USA. RP Stratis-Cullum, DN (reprint author), US Army Res Lab, Adelphi, MD USA. EM dimitra.n.stratis-cullum.civ@mail.mil FU US Army Research Laboratory Postdoctoral Fellowship Program FX This project is supported in part by appointments to the US Army Research Laboratory Postdoctoral Fellowship Program administered by the Oak Ridge Associated Universities through a contract with the US Army Research Laboratory. NR 42 TC 1 Z9 1 U1 3 U2 15 PU ICE PUBLISHING PI WESTMINISTER PA INST CIVIL ENGINEERS, 1 GREAT GEORGE ST, WESTMINISTER SW 1P 3AA, ENGLAND SN 2046-0147 EI 2046-0155 J9 EMERG MATER RES JI Emerg. Mater. Res. PD DEC PY 2015 VL 4 IS 2 BP 218 EP 222 DI 10.1680/emr.15.00028 PG 5 WC Materials Science, Multidisciplinary SC Materials Science GA CX5DA UT WOS:000365720600009 ER PT J AU Hulla, JE Sahu, SC Hayes, AW AF Hulla, J. E. Sahu, S. C. Hayes, A. W. TI Nanotechnology: History and future SO HUMAN & EXPERIMENTAL TOXICOLOGY LA English DT Article ID NANOSCALE MATERIALS; RESEARCH STRATEGIES; SAFETY EVALUATION; NANOPARTICLES; NANOMATERIALS; DELIVERY; CANCER C1 [Hulla, J. E.] US Army Corps Engn, Sacramento, CA USA. [Sahu, S. C.] US FDA, Div Toxicol, Off Appl Res & Safety Assessment, Ctr Food Safety & Appl Nutr, Laurel, MD USA. [Hayes, A. W.] Harvard Univ, Cambridge, MA 02138 USA. RP Hayes, AW (reprint author), Harvard Univ, Cambridge, MA 02138 USA. EM awallacehayes@comcast.net NR 30 TC 2 Z9 2 U1 10 U2 35 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0960-3271 EI 1477-0903 J9 HUM EXP TOXICOL JI Hum. Exp. Toxicol. PD DEC PY 2015 VL 34 IS 12 BP 1318 EP 1321 DI 10.1177/0960327115603588 PG 4 WC Toxicology SC Toxicology GA CX5ME UT WOS:000365745000017 PM 26614822 ER PT J AU Zhang, NY Ho, J Runt, J Zhang, SH AF Zhang, Nanyan Ho, Janet Runt, James Zhang, Shihai TI Light weight high temperature polymer film capacitors with dielectric loss lower than polypropylene SO JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS LA English DT Article ID ENERGY-STORAGE CAPACITORS; RELAXATION AB The dielectric and high voltage performance of polymethylpentene (PMP) is investigated and compared with biaxially-oriented polypropylene (BOPP) for high power density and high temperature capacitor applications. PMP has a melting temperature that is around 60 A degrees C higher than BOPP, while still maintaining low dielectric loss and high charge-discharge efficiency that are comparable to the latter. Furthermore, PMP is the lightest commercial thermoplastic polymer with density of 0.83 g/cm(3), which is 8 % lower than BOPP (0.9 g/cm(3)). PMP is a promising semicrystalline dielectric material that may replace BOPP for high temperature pulsed power and power conditioning applications. C1 [Zhang, Nanyan; Zhang, Shihai] PolyK Technol LLC, State Coll, PA 16801 USA. [Ho, Janet] US Army, Res Lab, Adelphi, MD 20783 USA. [Runt, James] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. RP Ho, J (reprint author), US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM janet.s.ho.civ@mail.mil; energy@polyktech.com FU U.S. Office of Naval Research [N00014-13C0234] FX This work was supported by the U.S. Office of Naval Research under contract number N00014-13C0234. NR 31 TC 2 Z9 2 U1 3 U2 22 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0957-4522 EI 1573-482X J9 J MATER SCI-MATER EL JI J. Mater. Sci.-Mater. Electron. PD DEC PY 2015 VL 26 IS 12 SI SI BP 9396 EP 9401 DI 10.1007/s10854-015-3152-7 PG 6 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Engineering; Materials Science; Physics GA CX2KP UT WOS:000365525900020 ER PT J AU Darling, KA Kapoor, M Kotan, H Hornbuckle, BC Walck, SD Thompson, GB Tschopp, MA Kecskes, LJ AF Darling, K. A. Kapoor, M. Kotan, H. Hornbuckle, B. C. Walck, S. D. Thompson, G. B. Tschopp, M. A. Kecskes, L. J. TI Structure and mechanical properties of Fe-Ni-Zr oxide-dispersion-strengthened (ODS) alloys SO JOURNAL OF NUCLEAR MATERIALS LA English DT Article DE Mechanical properties; Oxide-dispersion-strengthening; Atom probe tomography; Fe based ODS alloys; Zirconium-oxide ID NANOSTRUCTURED FERRITIC ALLOYS; HIGH-TEMPERATURE SYNTHESIS; 3-DIMENSIONAL ATOM-PROBE; THERMAL-STABILITY; PHASE-TRANSFORMATION; STEELS; PARTICLES; NANOCLUSTERS; DEFORMATION; IRRADIATION AB A series of bulk nanostructured Fe-Ni-Zr oxide-dispersion-strengthened (ODS) alloys were synthesized using high energy mechanical alloying and consolidated using high temperature equal channel angular extrusion. The resultant microstructures are composed of nano/ultrafine or micrometer-sized grains with larger intermetallic precipitates and small Zr oxide clusters (<10 nm diameter, measured and confirmed by atom probe tomography). The ODS alloys possess elevated compression properties, e.g., 1.2 and 2.4 GPa compressive yield stress at room temperature for samples consolidated at 700 degrees C and 1000 degrees C, respectively. This work highlights the relationship between processing, microstructure, and properties for this class of ferritic ODS alloys. Published by Elsevier B.V. C1 [Darling, K. A.; Hornbuckle, B. C.; Walck, S. D.; Tschopp, M. A.; Kecskes, L. J.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Kapoor, M.; Thompson, G. B.] Univ Alabama, Dept Met & Mat Engn, Tuscaloosa, AL 35487 USA. [Kotan, H.] Necmettin Erbakan Univ, Dept Met & Mat Engn, TR-42090 Konya, Turkey. RP Darling, KA (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM Kristopher.darling.civ@mail.mil RI Tschopp, Mark/B-1594-2008 OI Tschopp, Mark/0000-0001-8471-5035 FU Sandia National Laboratories through the Department of Energy Office of Basic Energy Sciences FX M. Kapoor and G.B. Thompson gratefully acknowledge support from Sandia National Laboratories through the Department of Energy Office of Basic Energy Sciences. NR 63 TC 2 Z9 2 U1 5 U2 21 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-3115 EI 1873-4820 J9 J NUCL MATER JI J. Nucl. Mater. PD DEC PY 2015 VL 467 BP 205 EP 213 DI 10.1016/j.jnucmat.2015.09.011 PN 1 PG 9 WC Materials Science, Multidisciplinary; Nuclear Science & Technology SC Materials Science; Nuclear Science & Technology GA CX3MJ UT WOS:000365602800021 ER PT J AU Hayman, WR Leuthner, SR Laventhal, NT Brousseau, DC Lagatta, JM AF Hayman, W. R. Leuthner, S. R. Laventhal, N. T. Brousseau, D. C. Lagatta, J. M. TI Cost comparison of mechanically ventilated patients across the age span SO JOURNAL OF PERINATOLOGY LA English DT Article ID EXTREMELY PRETERM INFANTS; CRITICAL-CARE MEDICINE; LONG-TERM OUTCOMES; HOME OXYGEN USE; INTENSIVE-CARE; UNITED-STATES; CARDIOPULMONARY-RESUSCITATION; SEVERE SEPSIS; BED NUMBERS; EPIDEMIOLOGY AB OBJECTIVE: To compare the use of mechanical ventilation and hospital costs across ventilated patients of all ages, preterm through adults, in a nationally representative sample. STUDY DESIGN: Secondary analysis of the 2009 Agency for Healthcare Research and Quality National Inpatient Sample. RESULTS: A total of 1 107 563 (2.8%) patients received mechanical ventilation. For surviving ventilated patients, median costs for infants <= 32 weeks' gestation were $51000 to $209 000, whereas median costs for older patients were lower from $17000 to $25 000. For non-surviving ventilated patients, median costs were $27 000 to $39 000 except at the extremes of age; the median cost was $10000 for <24 week newborns and $14000 for 91+ year adults. Newborns of all gestational ages had a disproportionate share of hospital costs relative to their total volume. CONCLUSION: Most intensive care unit resources at the extremes of age are not directed toward non-surviving patients. From a perinatal perspective, attention should be directed toward improving outcomes and reducing costs for all infants, not just at the earliest gestational ages. C1 [Hayman, W. R.] Tripler Army Med Ctr, Dept Pediat, Honolulu, HI 96859 USA. [Leuthner, S. R.; Brousseau, D. C.; Lagatta, J. M.] Med Coll Wisconsin, Dept Pediat, Milwaukee, WI 53226 USA. [Laventhal, N. T.] Univ Michigan, Dept Pediat & Communicable Dis, Ann Arbor, MI 48109 USA. RP Lagatta, JM (reprint author), Med Coll Wisconsin, Dept Pediat, 999 N,92nd St,Suite C410, Milwaukee, WI 53226 USA. EM jlagatta@mcw.edu FU National Center for Advancing Translational Sciences, National Institutes of Health [8UL1TR000055] FX This study was partially supported by the National Center for Advancing Translational Sciences, National Institutes of Health through Grant Number 8UL1TR000055. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH. NR 39 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0743-8346 EI 1476-5543 J9 J PERINATOL JI J. Perinatol. PD DEC PY 2015 VL 35 IS 12 BP 1020 EP 1026 DI 10.1038/jp.2015.131 PG 7 WC Obstetrics & Gynecology; Pediatrics SC Obstetrics & Gynecology; Pediatrics GA CX2XB UT WOS:000365559000010 PM 26468935 ER PT J AU Hydren, JR Cohen, BS AF Hydren, Jay R. Cohen, Bruce S. TI CURRENT SCIENTIFIC EVIDENCE FOR A POLARIZED CARDIOVASCULAR ENDURANCE TRAINING MODEL SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH LA English DT Review DE threshold; high-intensity interval training; high volume training; V; o(2)max; blood lactate; periodization ID HEART-RATE-VARIABILITY; INTENSITY DISTRIBUTION; OVERTRAINING SYNDROME; SPEED SKATERS; PERFORMANCE; THRESHOLD; RUNNERS; IMPACT; CYCLISTS AB Hydren, JR and Cohen, BS. Current scientific evidence for a polarized cardiovascular endurance training model. J Strength Cond Res 29(12): 3523-3530, 2015Recent publications have provided new scientific evidence for a modern aerobic or cardiovascular endurance exercise prescription that optimizes the periodization cycle and maximizes potential endurance performance gains in highly trained individuals. The traditional threshold, high volume, and high-intensity training models have displayed limited improvement in actual race pace in (highly) trained individuals while frequently resulting in overreaching or overtraining (physical injury and psychological burnout). A review of evidence for replacing these models with the proven polarized training model seems warranted. This review provides a short history of the training models, summarizes 5 key studies, and provides example training programs for both the pre- and in-season periods. A polarized training program is characterized by an undulating nonlinear periodization model with nearly all the training time spent at a light (13) and very hard (17) pace with very limited time at hard (14-16) or race pace (6-20 Rating of Perceived Exertion [RPE] scale). To accomplish this, the polarization training model has specific high-intensity workouts separated by one or more long slow distance workouts, with the exercise intensity remaining below ventilatory threshold (VT) 1 and/or blood lactate of less than 2 mM (A.K.A. below race pace). Effect sizes for increasing aerobic endurance performance for the polarized training model are consistently superior to that of the threshold training model. Performing a polarized training program may be best accomplished by: going easy on long slow distance workouts, avoiding race pace and getting after it during interval workouts. C1 [Hydren, Jay R.; Cohen, Bruce S.] US Army Res Inst Environm Med, Mil Performance Div, Natick, MA USA. RP Hydren, JR (reprint author), US Army Res Inst Environm Med, Mil Performance Div, Natick, MA USA. EM jayhydren@gmail.com RI Hydren, Jay/H-3654-2016 OI Hydren, Jay/0000-0001-9385-8898 NR 24 TC 0 Z9 0 U1 32 U2 42 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1064-8011 EI 1533-4287 J9 J STRENGTH COND RES JI J. Strength Cond. Res. PD DEC PY 2015 VL 29 IS 12 BP 3523 EP 3530 DI 10.1519/JSC.0000000000001197 PG 8 WC Sport Sciences SC Sport Sciences GA CX4ZY UT WOS:000365710900034 PM 26595137 ER PT J AU McKay, SK AF McKay, S. Kyle TI Quantifying Tradeoffs Associated with Hydrologic Environmental Flow Methods SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION LA English DT Article DE environmental flows; instream flows; minimum flows; sustainability boundaries; tradeoffs; Middle Oconee River ID UNITED-STATES; FRESH-WATER; RIVER; ECOSYSTEMS; MANAGEMENT; RULES; GEORGIA; REGIMES; NEEDS AB Freshwater management requires balancing and tradingoff multiple objectives, many of which may be competing. Ecological needs for freshwater are often described in terms of environmental flow recommendations (e.g., minimum flows), and there are many techniques for developing these recommendations, which range from hydrologic rules to multidisciplinary analyses supported by large teams of subject matter experts. Although hydrologic rules are well acknowledged as overly simplified, these techniques remain the state-of-the-practice in many locations. This article seeks to add complexity to the application of these techniques by studying the emergent properties of hydrologic environmental flow methodologies. Two hydrologic rules are applied: minimum flow criteria and sustainability boundaries. Objectives and metrics associated with withdrawal rate and similarity to natural flow regimes are used to tradeoff economic and environmental needs, respectively, over a range of flow thresholds and value judgments. A case study of hypothetical water withdrawals on the Middle Oconee River near Athens, Georgia is applied to demonstrate these techniques. For this case study, sustainability boundaries emerge as preferable relative to both environmental and economic outcomes. Methods applied here provide a mechanism for examining the role of stakeholder values and tradeoffs in application of hydrologic rules for environmental flows. C1 [McKay, S. Kyle] US Army, Engn Res & Dev Ctr, Environm Lab, Athens, GA 30339 USA. RP McKay, SK (reprint author), US Army, Engn Res & Dev Ctr, Environm Lab, 248 Georgia Ave, Athens, GA 30339 USA. EM kyle.mckay@usace.army.mil FU U.S. Army Corps of Engineers through the Ecosystem Management and Restoration Research Program FX The U.S. Army Corps of Engineers funded this research through the Ecosystem Management and Restoration Research Program (http://www.el.erdc.usace.army.mil/emrrp/). The opinions reflected here are those of the author and do not necessarily reflect those of the agency. A prior draft was significantly improved from comments by Alan Covich, Mary Freeman, Rhett Jackson, Bobby McComas, Bruce Pruitt, and John Schramski. NR 56 TC 0 Z9 0 U1 3 U2 15 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1093-474X EI 1752-1688 J9 J AM WATER RESOUR AS JI J. Am. Water Resour. Assoc. PD DEC PY 2015 VL 51 IS 6 BP 1508 EP 1518 DI 10.1111/1752-1688.12328 PG 11 WC Engineering, Environmental; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA CX6FX UT WOS:000365797700003 ER PT J AU Park, TS Batchinsky, AI Belenkiy, SM Jordan, BS Baker, WL Necsoiu, CN Aden, JK Dubick, MA Cancio, LC AF Park, Timothy S. Batchinsky, Andriy I. Belenkiy, Slava M. Jordan, Bryan S. Baker, William L. Necsoiu, Corina N. Aden, James K. Dubick, Michael A. Cancio, Leopoldo C. TI Resuscitative endovascular balloon occlusion of the aorta (REBOA): Comparison with immediate transfusion following massive hemorrhage in swine SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article; Proceedings Paper CT 45th Annual Meeting of the Western-Trauma-Association CY MAR 01-06, 2015 CL Telluride, CO SP Western Trauma Assoc DE Swine; shock; hemorrhagic; aorta; endovascular procedures ID NONCOMPRESSIBLE TORSO HEMORRHAGE; UK COMBAT CASUALTIES; THORACOTOMY; MODEL; SHOCK; EMERGENCY; OUTCOMES; INJURY AB BACKGROUND Resuscitative endovascular balloon occlusion of the aorta (REBOA) is less invasive than emergency department thoracotomy for the treatment of massive hemorrhage. We evaluated the effects of REBOA on carotid blood flow (Q(carotid)) in a porcine model of massive hemorrhage. We hypothesized that REBOA restores Q(carotid) faster than reinfusion of blood. METHODS Spontaneously breathing sedated Sinclair pigs underwent exponential hemorrhage of 65% total blood volume in 1 hour. They were randomized into three groups. Positive control (PC, n = 7) underwent immediate transfusion of shed blood. REBOA (n = 21) received a novel 7 Fr ER-REBOA catheter (Pryor Medical, Arvada, CO) placed into aortic Zone 1 via a femoral artery introducer for 30 minutes or 60 minutes, with transfusion either after deflation or midway through inflation. Negative control (n = 7) received no resuscitation. Q(carotid) was recorded continuously using an ultrasonic flow probe. Survival and time between Q(carotid, min) and both a stable maximal value (Q(carotid, max)) and restoration of baseline flow (Q(carotid, new BL)) were compared by Kaplan-Meier analysis. RESULTS Median time to Q(carotid, max) was 3.0 minutes in the REBOA group versus 9.6 minutes in the control group (p = 0.006). Median time to Q(carotid, new BL) was 6.0 minutes in the REBOA group versus 20.5 minutes in the PC group (p = 0.11). Slope of the linear regression between Q(carotid, min) and Q(carotid, new BL) was 16.7 in REBOA and 10.4 in PC (p = 0.31). Four-hour survival was 95% (20 of 21) in the REBOA group versus 71% (5 of 7) in the PC group (p = 0.06) and 0% in the negative control group. CONCLUSION REBOA resulted in the restoration of Q(carotid) (cerebrovascular resuscitation) at least as rapidly as retransfusion of shed blood, with equivalent 4-hour survival. Further studies of REBOA, to include mitigation of end-organ effects and longer follow-up, are needed. C1 [Park, Timothy S.] San Antonio Mil Med Ctr, Gen Surg Serv, San Antonio, TX USA. [Batchinsky, Andriy I.; Belenkiy, Slava M.; Jordan, Bryan S.; Baker, William L.; Necsoiu, Corina N.; Aden, James K.; Dubick, Michael A.; Cancio, Leopoldo C.] US Army Inst Surg Res, JBSA Ft Sam Houston, San Antonio, TX USA. RP Cancio, LC (reprint author), JBSA Ft Sam Houston, 3698 Chambers Pass, San Antonio, TX USA. EM divego99@gmail.com FU Telemedicine and Advanced Technologies Research Center, Fort Detrick, MD; Pryor Medical; Geneva Foundation, Tacoma, WA; US Department of Energy; US Army Medical Research and Materiel Command FX This study was funded by a grant by the Telemedicine and Advanced Technologies Research Center, Fort Detrick, MD, to Pryor Medical, Inc., Arvada, CO, and via a subcontract between Pryor Medical and the Geneva Foundation, Tacoma, WA, for the work performed at the US Army Institute of Surgical Research. This research was also supported in part by the appointment of L.C.C. to the Knowledge Preservation Program at the US Army Institute of Surgical Research, administered by the Oak Ridge Institute for Science and Education, through an interagency agreement between the US Department of Energy and the US Army Medical Research and Materiel Command. NR 14 TC 6 Z9 6 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD DEC PY 2015 VL 79 IS 6 BP 930 EP 936 DI 10.1097/TA.0000000000000877 PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA CX4TD UT WOS:000365692300009 PM 26680136 ER PT J AU Ernat, J Song, D Fazio, M Lindell, K Orchowski, J AF Ernat, Justin Song, Daniel Fazio, Michael Lindell, Kenneth Orchowski, Joseph TI Radiographic Changes and Fracture in Patients Having Received Bisphosphonate Therapy for >= 5 Years at a Single Institution SO MILITARY MEDICINE LA English DT Article ID FEMORAL-SHAFT FRACTURES; ALENDRONATE THERAPY; FEMUR; COMPLICATION; WOMEN; RISK; BONE AB Introduction: Bisphosphonates have been shown to reduce the incidence of vertebral fractures, as well as intertrochanteric and femoral neck fractures; however, data also demonstrate the association of prolonged use and atypical femur fractures. We intend to report the incidence of atypical femur fractures and cortical irregularities in patients from a single institution having received prolonged bisphosphonate therapy. Methods: A retrospective review of the pharmaceutical database was performed for all patients who were prescribed bisphosphonates at a single institution from 2002 to 2012. People taking bisphosphonates for >= 5 years were included. Those identified as having adequate radiographs with visualization of at least 5-cm distal to the lesser trochanter were selected. Radiographs were reviewed for evidence of atypical femur fractures or lateral cortical beaking. Medical records were retrospectively reviewed to determine any prodromal symptoms or clinical risk factors. Results: A total of 7,671 patients were identified between the years of 2002 and 2012 as having been prescribed bisphosphonates at a single institution. Of these, 1,684 were using bisphosphonates for >= 5 years (2002-2007). 396 patients taking bisphosphonates for greater than 5 years had adequate radiographs. In total, 8 patients (2.02%) had positive findings; 7 were females. More specifically, 2 (0.51%) patients had incomplete subtrochanteric fractures while 6 (1.52%) demonstrated lateral cortical beaking. Discussion/Conclusion: Over 2% of patients at our institution having received bisphosphonate therapy for >= 5 years demonstrated cortical irregularities or have already experienced an atypical femur fracture. These findings could call into question the need for radiographic screening for patients on prolonged bisphosphonate therapy. C1 [Ernat, Justin; Song, Daniel; Fazio, Michael; Lindell, Kenneth; Orchowski, Joseph] Tripler Army Med Ctr, Dept Orthoped Surg, Honolulu, HI 96859 USA. RP Ernat, J (reprint author), Tripler Army Med Ctr, Dept Orthoped Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. NR 19 TC 2 Z9 2 U1 1 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD DEC PY 2015 VL 180 IS 12 BP 1214 EP 1218 DI 10.7205/MILMED-D-14-00736 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA CX6ML UT WOS:000365815000013 PM 26633664 ER PT J AU Beals, K Darnell, ME Lovalekar, M Baker, RA Nagai, T San-Adams, T Wirt, MD AF Beals, Kim Darnell, Matthew E. Lovalekar, Mita Baker, Rachel A. Nagai, Takashi San-Adams, Thida Wirt, Michael D. TI Suboptimal Nutritional Characteristics in Male and Female Soldiers Compared to Sports Nutrition Guidelines SO MILITARY MEDICINE LA English DT Article ID HIGH-CARBOHYDRATE DIETS; EATING PATTERNS; PERFORMANCE; GARRISON; SUPPLEMENTATION; REQUIREMENTS; COMPETITION; FREQUENCY; ADEQUACY; RANGERS AB The purpose of this study was to evaluate the nutrient intake of male and female Soldiers in the 101st Airborne Division (Air Assault) compared to sports nutrition standards for athletes, and to identify suboptimal eating characteristics that may impair physical performance and jeopardize military readiness. Male and female Soldiers from the 101st Airborne Division (Air Assault) completed a 24-hour dietary recall and nutrition history questionnaire before anthropometric and body composition measurements were taken. Compared to sports nutrition guidelines, Soldiers of the 101st under consume carbohydrates (males: 3.9 +/- 2.0 vs. 5.0 g/kg, p < 0.001; females: 4.0 +/- 2.1 vs. 5.0 g/kg, p = 0.001), male Soldiers eat too much fat (32.4% of kcal vs. < 30% of kcal, p = 0.000) and saturated fat (males: 10.5 +/- 3.9% of kcal vs. 10.0% of kcal, p = 0.044), and both males and females follow a meal pattern that may not optimize energy availability throughout the day. Eating too much fat and under fueling carbohydrate may negatively impact the adaptations to physical training and compromise overall health. Although Soldiers continue to participate in arduous training programs, future research should be aimed at determining the energy and macronutrient needs to fuel and recover from specific types of military training. C1 [Beals, Kim; Darnell, Matthew E.; Lovalekar, Mita; Baker, Rachel A.; Nagai, Takashi; San-Adams, Thida] Univ Pittsburgh, Neuromuscular Res Lab, Dept Sports Med & Nutr, Pittsburgh, PA 15203 USA. [Wirt, Michael D.] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX 78234 USA. RP Beals, K (reprint author), Univ Pittsburgh, Neuromuscular Res Lab, Dept Sports Med & Nutr, 3840 South Water St, Pittsburgh, PA 15203 USA. FU U.S. Army Medical Research and Materiel Command (Research grant USAMRMC/TATRC) [W81XWH-06-2-0070, W81XWH-09-2-0095, W81XWH-11-2-0097] FX This work was supported by the U.S. Army Medical Research and Materiel Command (Research grant USAMRMC/TATRC # W81XWH-06-2-0070/W81XWH-09-2-0095/W81XWH-11-2-0097). Opinions, interpretations, conclusions, and recommendations are those of the author and not necessarily endorsed by the U.S. Army. NR 50 TC 0 Z9 0 U1 2 U2 6 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD DEC PY 2015 VL 180 IS 12 BP 1239 EP 1246 DI 10.7205/MILMED-D-14-00515 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA CX6ML UT WOS:000365815000017 PM 26633668 ER PT J AU Boyle, EW AF Boyle, Eric W. TI The Surprising Origins of a World War II-Era Mural That Was Nearly Lost SO MILITARY MEDICINE LA English DT Editorial Material C1 [Boyle, Eric W.] US Army Med Res & Mat Command, Natl Museum Hlth & Med, Silver Spring, MD 20910 USA. RP Boyle, EW (reprint author), US Army Med Res & Mat Command, Natl Museum Hlth & Med, 2500 Linden Lane, Silver Spring, MD 20910 USA. NR 4 TC 0 Z9 0 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD DEC PY 2015 VL 180 IS 12 BP 1273 EP 1274 DI 10.7205/MILMED-D-15-00395 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA CX6ML UT WOS:000365815000022 PM 26633673 ER PT J AU Acevedo, JL Camacho, M Brietzke, SE AF Acevedo, Jason L. Camacho, Macario Brietzke, Scott E. TI Radiofrequency Ablation Turbinoplasty versus Microdebrider-Assisted Turbinoplasty: A Systematic Review and Meta-analysis SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Review DE turbinoplasty; turbinate reduction; systematic review; nasal congestion; allergic rhinitis ID INFERIOR TURBINATE HYPERTROPHY; PERENNIAL ALLERGIC RHINITIS; COMPUTED-TOMOGRAPHY; THERMAL ABLATION; FOLLOW-UP; REDUCTION; EFFICACY; AIRWAY; TRIAL; LASER AB Objective To critically review published literature for treatment-related outcomes for bilateral inferior turbinate reduction (IFTR) via either microdebrider-assisted turbinoplasty (MAT) or radiofrequency turbinoplasty. The primary outcomes were relief of nasal obstruction according to visual analog scale and nasal airflow, volume, and resistance measures based on acoustic rhinomanometry. Data Sources MEDLINE, EMBASE, The Cochrane Catalog, and CINAHL. Review Methods The databases were searched with the terms turbinoplasty and turbinate reduction. Inclusion criteria were English language, human subjects, and studies specifically relating to IFTR with radiofrequency turbinoplasty or MAT. Exclusion criteria were pediatric patients and concurrent nasal procedures. Results were tabulated, and the data were analyzed per random effects modeling. Subgroup analysis and quality assessment were also performed. Results A total of 976 articles were initially identified, with 26 meeting the inclusion/exclusion criteria. Random effects modeling demonstrated a significant improvement after IFTR, as measured with the visual analog scale (4.26-point improvement, 95% confidence interval [95% CI] = 3.32-5.20, P < .001, k = 21 studies, I-2 = 99%) and with acoustic rhinomanometry measurements of volume (2.43-cm(3) improvement, 95% CI = 0.48-4.38, P = .015, k = 6 studies, I-2 = 99%), flow (203-mL/s improvement, 95% CI = 131-276, P < .001, k = 4 studies, I-2 = 99%), and resistance change (2.78-Pa/cm(3) improvement, 95% CI = 0.433-5.13, P = .020, k = 5 studies, I-2 = 99%). There was no difference in outcome by technique, allergic rhinitis, or quality score. The 2 highest-quality papers favored MAT. The median follow-up was 6 months. Conclusions IFTR produces a significant subjective and objective improvement in nasal airflow in the short term. This change does not appear to be related to the technique used for IFTR. C1 [Acevedo, Jason L.] Reynolds Army Community Hosp, Ft Sill, OK USA. [Acevedo, Jason L.; Brietzke, Scott E.] Uniformed Serv Univ Hlth Sci, Bethesda, MD USA. [Camacho, Macario] Stanford Univ, Palo Alto, CA 94304 USA. [Brietzke, Scott E.] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA. RP Acevedo, JL (reprint author), Reynolds Army Community Hosp, 1665 Antilley Rd,Suite 160, Abilene, TX 79602 USA. EM aggiedoc2000@gmail.com OI Camacho, Macario/0000-0001-9200-9085 FU American Academy of Otolaryngology-Head and Neck Surgery FX American Academy of Otolaryngology-Head and Neck Surgery. NR 30 TC 1 Z9 1 U1 0 U2 0 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0194-5998 EI 1097-6817 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD DEC PY 2015 VL 153 IS 6 BP 951 EP 956 DI 10.1177/0194599815607211 PG 6 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA CX5LS UT WOS:000365743700012 PM 26450750 ER PT J AU Cohen, SP Peterlin, BL Fulton, L Neely, ET Kurihara, C Gupta, A Mali, J Fu, DC Jacobs, MB Plunkett, AR Verdun, AJ Stojanovic, MP Hanling, S Constantinescu, O White, RL McLean, BC Pasquina, PF Zhao, ZR AF Cohen, Steven P. Peterlin, B. Lee Fulton, Larry Neely, Edward T. Kurihara, Connie Gupta, Anita Mali, Jimmy Fu, Diana C. Jacobs, Michael B. Plunkett, Anthony R. Verdun, Aubrey J. Stojanovic, Milan P. Hanling, Steven Constantinescu, Octav White, Ronald L. McLean, Brian C. Pasquina, Paul F. Zhao, Zirong TI Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness SO PAIN LA English DT Article DE Headache; Occipital neuralgia; Pulsed radiofrequency; Steroid injection ID DORSAL-ROOT GANGLION; CHRONIC CLUSTER HEADACHE; CERVICAL RADICULAR PAIN; CONTROLLED-TRIAL; MECHANICAL ALLODYNIA; NEUROPATHIC PAIN; RADIO-FREQUENCY; GREATER; MULTICENTER; BLOCKADE AB Occipital neuralgia (ON) is characterized by lancinating pain and tenderness overlying the occipital nerves. Both steroid injections and pulsed radiofrequency (PRF) are used to treat ON, but few clinical trials have evaluated efficacy, and no study has compared treatments. We performed a multicenter, randomized, double-blind, comparative-effectiveness study in 81 participants with ON or migraine with occipital nerve tenderness whose aim was to determine which treatment is superior. Forty-two participants were randomized to receive local anesthetic and saline, and three 120 second cycles of PRF per targeted nerve, and 39 were randomized to receive local anesthetic mixed with deposteroid and 3 rounds of sham PRF. Patients, treating physicians, and evaluators were blinded to interventions. The PRF group experienced a greater reduction in the primary outcome measure, average occipital pain at 6 weeks (mean change from baseline 22.743 +/- 2.487 vs 21.377 +/- 1.970; P < 0.001), than the steroid group, which persisted through the 6-month follow-up. Comparable benefits favoring PRF were obtained for worst occipital pain through 3 months (mean change from baseline21.925 +/- 3.204 vs20.541 +/- 2.644; P = 0.043), and average overall headache pain through 6 weeks (mean change from baseline 22.738 +/- 2.753 vs 21.120 +/- 2.1; P = 0.037). Adverse events were similar between groups, and few significant differences were noted for nonpain outcomes. We conclude that although PRF can provide greater pain relief forONandmigrainewith occipital nerve tenderness than steroid injections, the superior analgesia may not be accompanied by comparable improvement on other outcome measures. C1 [Cohen, Steven P.] Johns Hopkins Sch Med, Dept Anesthesiol & Crit Care Med, Baltimore, MD USA. [Cohen, Steven P.] Johns Hopkins Sch Med, Dept Phys Med & Rehabil, Baltimore, MD USA. [Cohen, Steven P.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Peterlin, B. Lee] Johns Hopkins Sch Med, Dept Neurol, Baltimore, MD USA. [Fulton, Larry] Texas Tech Sch Med, Dept Hlth Org Management, Lubbock, TX USA. [Neely, Edward T.] Walter Reed Natl Mil Med Ctr, Dept Neurol, Bethesda, MD USA. [Kurihara, Connie] Walter Reed Natl Mil Med Ctr, Dept Surg, Bethesda, MD USA. [Kurihara, Connie] Walter Reed Natl Mil Med Ctr, Dept Nursing, Bethesda, MD USA. [Gupta, Anita] Drexel Univ, Dept Anesthesiol, Philadelphia, PA 19104 USA. [Mali, Jimmy; Plunkett, Anthony R.] Womack Army Med Ctr, Ft Bragg, NC USA. [Fu, Diana C.] Naval Med Ctr San Diego, Dept Neurol, San Diego, CA USA. [Jacobs, Michael B.] Walter Reed Natl Mil Med Ctr, Dept Phys Med & Rehabil, Bethesda, MD USA. [Verdun, Aubrey J.] Walter Reed Natl Mil Med Ctr, Dept Anesthesiol, Bethesda, MD USA. [Stojanovic, Milan P.] Boston VA Hosp, Dept Anesthesiol, Boston, MA USA. [Hanling, Steven] Naval Med Ctr San Diego, Dept Anesthesiol, San Diego, CA USA. [Constantinescu, Octav; White, Ronald L.] Landstuhl Reg Med Ctr, Dept Surg, Landstuhl, Germany. [McLean, Brian C.] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. [Pasquina, Paul F.] Uniformed Serv Univ Hlth Sci, Dept Phys Med & Rehabil, Bethesda, MD 20814 USA. [Pasquina, Paul F.] DC VA Hosp, Dept Internal Med, Washington, DC USA. [Zhao, Zirong] DC VA Hosp, Dept Neurol, Washington, DC USA. RP Cohen, SP (reprint author), Johns Hopkins Dept Anesthesiol, 550 North Broadway,Suite 301, Baltimore, MD 21205 USA. EM scohen40@jhmi.edu FU Center for Rehabilitation Sciences Research, Bethesda, MD FX Funded by a Congressional Grant from the Center for Rehabilitation Sciences Research, Bethesda, MD; Role of funding source: The role of the funding source was to pay for non-government personnel and to reimburse institutions for the costs of the procedures. NR 59 TC 1 Z9 2 U1 2 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3959 EI 1872-6623 J9 PAIN JI Pain PD DEC PY 2015 VL 156 IS 12 BP 2585 EP 2594 DI 10.1097/j.pain.0000000000000373 PG 10 WC Anesthesiology; Clinical Neurology; Neurosciences SC Anesthesiology; Neurosciences & Neurology GA CX3KS UT WOS:000365598300024 PM 26447705 ER PT J AU Pati, S Pilia, M Grimsley, JM Karanikas, AT Oyeniyi, B Holcomb, JB Cap, AP Rasmussen, TE AF Pati, Shibani Pilia, Marcello Grimsley, Juanita M. Karanikas, Alexia T. Oyeniyi, Blessing Holcomb, John B. Cap, Andrew P. Rasmussen, Todd E. TI CELLULAR THERAPIES IN TRAUMA AND CRITICAL CARE MEDICINE: FORGING NEW FRONTIERS SO SHOCK LA English DT Review DE Acute kidney injury; acute renal failure; burns; cellular therapies; extremity injury; hemorrhagic shock; neurotrauma; organ injury; orthopedic trauma; spinal cord injury; stem cells; trauma and critical care medicine; traumatic brain injury; wound healing ID MESENCHYMAL STEM-CELLS; SPINAL-CORD-INJURY; RESPIRATORY-DISTRESS-SYNDROME; ACUTE KIDNEY INJURY; RANDOMIZED CONTROLLED-TRIAL; MARROW STROMAL CELLS; ACUTE LUNG INJURY; ACUTE-RENAL-FAILURE; EXTREMITY VASCULAR INJURY; BONE-MARROW AB Trauma is a leading cause of death in both military and civilian populations worldwide. Although medical advances have improved the overall morbidity and mortality often associated with trauma, additional research and innovative advancements in therapeutic interventions are needed to optimize patient outcomes. Cell-based therapies present a novel opportunity to improve trauma and critical care at both the acute and chronic phases that often follow injury. Although this field is still in its infancy, animal and human studies suggest that stem cells may hold great promise for the treatment of brain and spinal cord injuries, organ injuries, and extremity injuries such as those caused by orthopedic trauma, burns, and critical limb ischemia. However, barriers in the translation of cell therapies that include regulatory obstacles, challenges in manufacturing and clinical trial design, and a lack of funding are critical areas in need of development. In 2015, the Department of Defense Combat Casualty Care Research Program held a joint military-civilian meeting as part of its effort to inform the research community about this field and allow for effective planning and programmatic decisions regarding research and development. The objective of this article is to provide a state of the science review regarding cellular therapies in trauma and critical care, and to provide a foundation from which the potential of this emerging field can be harnessed to mitigate outcomes in critically ill trauma patients. C1 [Pati, Shibani] Blood Syst Res Inst, San Francisco, CA USA. [Pati, Shibani] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Pilia, Marcello; Grimsley, Juanita M.; Rasmussen, Todd E.] Combat Casualty Care Res Program, Ft Detrick, MD USA. [Karanikas, Alexia T.] Booz Allen Hamilton, Rockville, MD USA. [Oyeniyi, Blessing; Holcomb, John B.] Univ Texas Houston, Dept Surg, Houston, TX USA. [Cap, Andrew P.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Rasmussen, TE (reprint author), US Army, Med Res Mat Command, Combat Casualty Care Res Program, 722 Doughten Dr,Bldg 722, Ft Detrick, MD 21702 USA. EM todd.e.rasmussen.mil@mail.mil NR 149 TC 3 Z9 3 U1 0 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD DEC PY 2015 VL 44 IS 6 BP 505 EP 523 DI 10.1097/SHK.0000000000000482 PG 19 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA CX4LZ UT WOS:000365673700002 PM 26428845 ER PT J AU Janak, JC Howard, JT Goei, KA Weber, R Muniz, GW Hinojosa-Laborde, C Convertino, VA AF Janak, Jud C. Howard, Jeffrey T. Goei, Kathleen A. Weber, Rachael Muniz, Gary W. Hinojosa-Laborde, Carmen Convertino, Victor A. TI PREDICTORS OF THE ONSET OF HEMODYNAMIC DECOMPENSATION DURING PROGRESSIVE CENTRAL HYPOVOLEMIA: COMPARISON OF THE PERIPHERAL PERFUSION INDEX, PULSE PRESSURE VARIABILITY, AND COMPENSATORY RESERVE INDEX SO SHOCK LA English DT Article DE Hemorrhage; hypovolemia; physiologic monitoring; shock ID BODY NEGATIVE-PRESSURE; HEART-RATE-VARIABILITY; TRAUMA PATIENTS; BLOOD-LOSS; COMBAT CASUALTIES; ARTERIAL-PRESSURE; SEPTIC SHOCK; HEMORRHAGE; TOLERANCE; HYPOTENSION AB Introduction:As technological advances allow for the development of more sophisticated measurement of the mechanisms that contribute to compensation for loss of circulating blood volume such as hemorrhage, it is important to compare the discriminative ability of these new measures to standard vital signs and other new physiologic metrics of interest. The purpose of this study was to compare the discriminative ability of the following three measures to predict the onset of hemodynamic decompensation: peripheral perfusion index (PPI), pulse pressure variability (PPV), and the compensatory reserve index (CRI).Materials and Methods:There were 51 healthy participants who underwent a progressive simulated hemorrhage to induce central hypovolemia by lower body negative pressure (LBNP). The least-squares means and 95% confidence intervals for each measure were reported by LBNP level and stratified by tolerance status (high tolerance vs. low tolerance). Generalized estimating equations were used to perform repeated measures logistic regression analysis by regressing the onset of hemodynamic decompensation on each of the vital signs of interest. These probabilities were used to calculate sensitivity, specificity, and receiver-operating characteristic area under the curve (ROCAUC) for PPI, PPV, and CRI.Results:Compared with both PPV (ROCAUC=0.79) and PPI (0.56), the CRI (0.90) had superior discriminative ability (P0.0001) to predict the onset of hemodynamic decompensation. This included higher sensitivity (0.86 vs. 0.78 and 0.71) and specificity (0.78 vs. 0.69 and 0.29) for the CRI compared with PPV and PPI, respectively. Further, CRI was the only measure with mean predicted probabilities of the onset of hemodynamic decompensation that progressively increased as the level of simulated hemorrhage increased.Discussion:There are two potential rationales for why the CRI had superior discriminative ability to predict hemodynamic decompensation. First, the CRI more accurately predicted the onset of hemodynamic decompensation at all levels of simulated hemorrhage, but especially at lower levels of hemorrhage. Second, the CRI was better able to differentiate high versus low tolerant participants.Conclusion:Consistent with previous research, the CRI had superior discriminative ability to predict the onset of hemodynamic decompensation. For those patients at greatest risk for developing impending circulatory shock, identifying the most sensitive and specific measures of the onset of hemodynamic decompensation is critical for both the early recognition and implementation of life-saving interventions. C1 [Janak, Jud C.; Howard, Jeffrey T.; Muniz, Gary W.; Hinojosa-Laborde, Carmen; Convertino, Victor A.] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX USA. [Goei, Kathleen A.] Univ Incarnate Word, San Antonio, TX USA. [Weber, Rachael] Univ Texas San Antonio, San Antonio, TX USA. RP Janak, JC (reprint author), 3698 Chambers Pass,Bldg 3611, San Antonio, TX 78234 USA. EM judson.c.janak.vol@mail.mil FU Internship/Research Participation Program at the United States Army Institute of Surgical Research; US Army Combat Casualty Care Research Program [D-009-2014-USAISR] FX Support and funding for this study was provided in part by an appointment to the Internship/Research Participation Program at the United States Army Institute of Surgical Research, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and EPA, and a grant from the US Army Combat Casualty Care Research Program (D-009-2014-USAISR). The authors report no conflicts of interest. NR 38 TC 3 Z9 3 U1 2 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD DEC PY 2015 VL 44 IS 6 BP 548 EP 553 DI 10.1097/SHK.0000000000000480 PG 6 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA CX4LZ UT WOS:000365673700006 PM 26529655 ER PT J AU Prat, NJ Meyer, AD Langer, T Montgomery, RK Parida, BK Batchinsky, AI Cap, AP AF Prat, Nicolas J. Meyer, Andrew D. Langer, Thomas Montgomery, Robbie K. Parida, Bijaya K. Batchinsky, Andriy I. Cap, Andrew P. TI LOW-DOSE HEPARIN ANTICOAGULATION DURING EXTRACORPOREAL LIFE SUPPORT FOR ACUTE RESPIRATORY DISTRESS SYNDROME IN CONSCIOUS SHEEP SO SHOCK LA English DT Article DE Acute respiratory distress syndrome; anticoagulation; blood platelet; extracorporeal life support; extracorporeal membrane oxygenation; trauma ID TRAUMATIC BRAIN-INJURY; ACUTE LUNG INJURY; MEMBRANE-OXYGENATION; GAS-EXCHANGE; UNITED-STATES; PLATELET; FAILURE; VENTILATION; ADULTS; BLOOD AB Background:Over 32% of burned battlefield causalities develop trauma-induced hypoxic respiratory failure, also known as acute respiratory distress syndrome (ARDS). Recently, 9 out of 10 US combat soldiers' survived life-threatening trauma-induced ARDS supported with extracorporeal membrane oxygenation (ECMO), a portable form of cardiopulmonary bypass. Unfortunately, the size, incidence of coagulation complications, and the need for systematic anticoagulation for traditional ECMO devices have prevented widespread use of this lifesaving technology. Therefore, a compact, mobile, ECMO system using minimal anticoagulation may be the solution to reduce ARDS in critically ill military and civilian patients.Methods:We conducted a prospective cohort laboratory investigation to evaluate the coagulation function in an ovine model of oleic acid induced ARDS supported with veno-venous ECMO. The experimental design approximated the time needed to transport from a battlefield setting to an advanced facility and compared bolus versus standard heparin anticoagulation therapy.Results:Comprehensive coagulation and hemostasis assays did not show any difference because of ECMO support over 10h between the two groups but did show changes because of injury. Platelet count and function did decrease with support on ECMO, but there was no significant bleeding or clot formation during the entire experiment.Conclusions:A bolus heparin injection is sufficient to maintain ECMO support for up to 10h in an ovine model of ARDS. With a reduced need for systematic anticoagulation, ECMO use for battlefield trauma could reduce significant morbidity and mortality from ventilator-induced lung injury and ARDS. Future studies will investigate the mechanisms and therapies to support patients for longer periods on ECMO without coagulation complications.Level of Evidence:Vtherapeutic animal experiment. C1 [Prat, Nicolas J.] French Armed Forces Inst Biomed Res IRBA, Paris, France. [Meyer, Andrew D.] Univ Texas Hlth Sci Ctr San Antonio, Div Pediat Crit Care, San Antonio, TX 78229 USA. [Langer, Thomas] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Anesthesia Intens Care Med Emergency & Urgen, Milan, Italy. [Meyer, Andrew D.; Montgomery, Robbie K.; Parida, Bijaya K.; Cap, Andrew P.] US Army Inst Surg Res, Coagulat & Blood Res, Ft Sam Houston, TX USA. [Langer, Thomas; Batchinsky, Andriy I.] US Army Inst Surg Res, Comprehens Intens Care Res, Ft Sam Houston, TX USA. RP Meyer, AD (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Pediat Crit Care, 7703 Floyd Curl Dr MC 7829, San Antonio, TX 78229 USA. EM meyera@uthscsa.edu RI PRAT, Nicolas/R-4213-2016 FU NCATS NIH HHS [KL2 TR001118] NR 44 TC 4 Z9 4 U1 1 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD DEC PY 2015 VL 44 IS 6 BP 560 EP 568 DI 10.1097/SHK.0000000000000459 PG 9 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA CX4LZ UT WOS:000365673700008 PM 26263439 ER PT J AU Phasomkusolsil, S Pantuwattana, K Tawong, J Khongtak, W Kertmanee, Y Monkanna, N Klein, TA Kim, HC McCardle, PW AF Phasomkusolsil, Siriporn Pantuwattana, Kanchana Tawong, Jaruwan Khongtak, Weeraphan Kertmanee, Yossasin Monkanna, Nantaporn Klein, Terry A. Kim, Heung-Chul McCardle, Patrick W. TI The relationship between wing length, blood meal volume, and fecundity for seven colonies of Anopheles species housed at the Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand SO ACTA TROPICA LA English DT Article DE Anopheles; Blood meal volume; Wing length; Feeding duration; Oviposition ID REPUBLIC-OF-KOREA; AEDES-AEGYPTI; REPRODUCTIVE SUCCESS; DIPTERA-CULICIDAE; CULEX-NIGRIPALPUS; FEEDING SUCCESS; MALARIA VECTORS; SIZE VARIATION; BODY-SIZE; MOSQUITO AB Established colonies of Anopheles campestris, Anopheles cracens, Anopheles dirus, Anopheles kleini, Anopheles minimus, Anopheles sawadwongporni, and Anopheles sinensis are maintained at the Armed Forces Research Institute of Medical Sciences (AFRIMS). Females were provided blood meals on human blood containing citrate as an anticoagulant using an artificial membrane feeder. The mean wing length, used as an estimate of body size, for each species was compared to blood-feeding duration (time), blood meal volume, and numbers of eggs oviposited. Except for An. campestris and An. cracens, there were significant interspecies differences in wing length. The mean blood meal volumes (mm(3)) of An. kleini and An. sinensis were significantly higher than the other 5 species. For all species, the ratios of unfed females weights/blood meal volumes were similar (range: 0.76-0.88), except for An. kleini (1.08) and An. cracens (0.52), that were significantly higher and lower, respectively. Adult females were allowed to feed undisturbed for 1, 3, and 5 mm intervals before blood feeding was interrupted. Except for An. cam pestris and An. sawadwongporni, the number of eggs oviposited were significantly higher for females that fed for 3 min when compared to those that only fed for 1 min. This information is critical to better understand the biology of colonized Anopheles spp. and their role in the transmission of malaria parasites as they relate to the relative size of adult females, mean volumes of blood of engorged females for each of the anopheline species, and the effect of blood feeding duration on specific blood meal volumes and fecundity. (C) 2015 Elsevier B.V. All rights reserved. C1 [Phasomkusolsil, Siriporn; Pantuwattana, Kanchana; Tawong, Jaruwan; Khongtak, Weeraphan; Kertmanee, Yossasin; Monkanna, Nantaporn; McCardle, Patrick W.] US Army Med Component, Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Klein, Terry A.] Publ Hlth Command Reg Pacific, Camp Zama, Japan. [Kim, Heung-Chul] 168th Multifunct Med Battal, Med Detachment 5, APO, AP 96205 USA. RP Phasomkusolsil, S (reprint author), US Army Med Component, Armed Forces Res Inst Med Sci, Dept Entomol, 315-6 Ratchawithi Rd, Bangkok 10400, Thailand. EM siripornp@afrims.org FU U.S. Army Medical and Material Command, Fort Detrick, MD; Armed Forces Health Surveillance Center, Global Emerging Infections Surveillance and Response System (AFHSC-GEIS), Silver Spring, MD; Public Health Command Region-Pacific, Camp Zama, Japan; 65th Medical Brigade, Yongsan US Army Garrison, Seoul, Korea FX Funding for this project was partially provided by the U.S. Army Medical and Material Command, Fort Detrick, MD, the Armed Forces Health Surveillance Center, Global Emerging Infections Surveillance and Response System (AFHSC-GEIS), Silver Spring, MD, the Public Health Command Region-Pacific, Camp Zama, Japan, and the 65th Medical Brigade, Yongsan US Army Garrison, Seoul, Korea. The views expressed in this paper are those of the authors and do not represent the position and/or reflect the official policy of the Department of the Army, the Department of Defense or the U.S. Government. NR 42 TC 1 Z9 1 U1 1 U2 15 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0001-706X EI 1873-6254 J9 ACTA TROP JI Acta Trop. PD DEC PY 2015 VL 152 BP 220 EP 227 DI 10.1016/j.actatropica.2015.09.021 PG 8 WC Parasitology; Tropical Medicine SC Parasitology; Tropical Medicine GA CW5SW UT WOS:000365057900032 PM 26433074 ER PT J AU Excler, JL Robb, ML Kim, JH AF Excler, Jean-Louis Robb, Merlin L. Kim, Jerome H. TI Prospects for a Globally Effective HIV-1 Vaccine SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; BROADLY NEUTRALIZING ANTIBODIES; RECOMBINANT GLYCOPROTEIN-120 VACCINE; T-CELL VACCINE; CONTROLLED PHASE-3 TRIAL; HIGHLY PATHOGENIC SIV; RHESUS-MONKEYS; EFFICACY TRIAL; IMMUNE-RESPONSES; DOUBLE-BLIND AB A globally effective vaccine strategy must cope with the broad genetic diversity of HIV and contend with multiple transmission modalities. Understanding correlates of protection and the role of diversity in limiting protective vaccines with those correlates is key. RV144 was the first HIV-1 vaccine trial to demonstrate efficacy against HIV-1 infection. A correlates analysis comparing vaccine-induced immune responses in vaccinated-infected and vaccinated-uninfected volunteers suggested that IgG specific for the V1V2 region of gp120 was associated with reduced risk of HIV-1 infection and that plasma Env IgA was directly correlated with infection risk. RV144 and recent non-human primate (NHP) challenge studies suggest that Env is essential and perhaps sufficient to induce protective antibody responses against mucosally acquired HIV-1. Whether RV144 immune correlates can apply to different HIV vaccines, to populations with different modes and intensity of transmission, or to divergent HIV-1 subtypes remains unknown. Newer prime-boost mosaic and conserved sequence immunization strategies aiming at inducing immune responses of greater breadth and depth as well as the development of immunogens inducing broadly neutralizing antibodies should be actively pursued. Efficacy trials are now planned in heterosexual populations in southern Africa and men who have sex with men in Thailand. Although NHP challenge studies may guide vaccine development, human efficacy trials remain key to answer the critical questions leading to the development of a global HIV-1 vaccine for licensure. (C) 2015 by American Journal of Preventive Medicine and Elsevier Ltd. All rights reserved. C1 [Excler, Jean-Louis; Robb, Merlin L.; Kim, Jerome H.] Walter Reed Army Inst Res, US Mil HIV Res Program, Bethesda, MD USA. [Excler, Jean-Louis; Robb, Merlin L.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. RP Excler, JL (reprint author), US Mil HIV Res Program MHRP, 6720-A Rockledge Dr,Suite 400, Bethesda, MD 20817 USA. EM jexcler@hivresearch.org FU Merck; Novartis; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; U.S. Department of Defense (DOD) [W81XWH-07-2-0067] FX This article is being published concurrently in the American Journal of Preventive Medicine and Vaccine. The articles are identical except for stylistic changes in keeping with each journal's style. Either of these versions may be used in citing this article. Publication of this article was supported by Merck and Novartis.; The preparation of this manuscript was supported in part by an Interagency Agreement Y1-AI-2642-12 between U.S. Army Medical Research and Materiel Command (USAMRMC) and the National Institutes of Allergy and Infectious Diseases. In addition, this work was supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense (DOD). NR 154 TC 5 Z9 6 U1 2 U2 15 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 EI 1873-2607 J9 AM J PREV MED JI Am. J. Prev. Med. PD DEC PY 2015 VL 49 IS 6 SU 4 BP S307 EP S318 DI 10.1016/j.amepre.2015.09.004 PG 12 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA CW5UI UT WOS:000365061700002 PM 26590431 ER PT J AU Thomas, SJ Rothman, AL AF Thomas, Stephen J. Rothman, Alan L. TI Trials and Tribulations on the Path to Developing a Dengue Vaccine SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID HUMAN INFECTION MODEL; CLINICAL LABORATORY RESPONSES; NEUTRALIZING ANTIBODY-LEVELS; HEALTHY ADULT VOLUNTEERS; FLAVIVIRUS-NAIVE ADULTS; PRIMARY-SCHOOL CHILDREN; VIRUS-INFECTION; NONHUMAN-PRIMATES; HUMAN CHALLENGE; JAPANESE ENCEPHALITIS AB Dengue is a rapidly expanding global health problem. Development of a safe and efficacious tetravalent vaccine along with strategic application of vector control activities represents a promising approach to reducing the global disease burden. Although many vaccine development challenges exist, numerous candidates are in clinical development and one has been tested in three clinical endpoint studies. The results of these studies have raised numerous questions about how we measure vaccine immunogenicity and how these readouts are associated with clinical outcomes in vaccine recipients who experience natural infection. In this review the authors discuss the dengue vaccine pipeline, development challenges, the dengue vaccine-immunologic profiling intersection, and research gaps. (C) 2015 by American Journal of Preventive Medicine and Elsevier Ltd. All rights reserved. C1 [Thomas, Stephen J.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Rothman, Alan L.] Univ Rhode Isl, Providence, RI 02908 USA. RP Thomas, SJ (reprint author), Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. EM stephen.j.thomas3.mil@mail.mil OI Rothman, Alan/0000-0002-4064-6848 FU Merck; Novartis FX This article is being published concurrently in the American Journal of Preventive Medicine and Vaccine. The articles are identical except for stylistic changes in keeping with each journal's style. Either of these versions may be used in citing this article. Publication of this article was supported by Merck and Novartis. NR 135 TC 5 Z9 5 U1 0 U2 7 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 EI 1873-2607 J9 AM J PREV MED JI Am. J. Prev. Med. PD DEC PY 2015 VL 49 IS 6 SU 4 BP S334 EP S344 DI 10.1016/j.amepre.2015.09.006 PG 11 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA CW5UI UT WOS:000365061700004 PM 26590433 ER PT J AU Bair, EH Simenhois, R van Hervvijnen, A Birkeland, KW AF Bair, Edward H. Simenhois, Ron van Hervvijnen, Alec Birkeland, Karl W. TI Using 2 m Extended Column Tests to assess slope stability SO COLD REGIONS SCIENCE AND TECHNOLOGY LA English DT Article DE Snow; Avalanche; Stability tests; Extended Column Tests ID PROPAGATION; FRACTURE AB Extended Column Tests (ECTs) are used to assess crack initiation and propagation. Previous research shows that tests 90 cm in length may propagate, suggesting instability, while tests 2 m in length may not propagate, suggesting stability, for identical snowpacks. A practical question is: are 90 cm ECTs optimal for assessing stability? To test the added value of 2 m ECTs for stability evaluation, we collected data on 220 ECTs, with 136 side-by-side standard length ECTPs (full propagation indicating instability) followed by 2 m ECTs. We only performed 2 m ECTs after a standard ECT propagated because we assumed 2 m ECTs would not propagate if standard length tests did not. These tests were preceded by an a priori stability assessment. Our results show imbalances for both tests. The ECT had a similar probability of detection (0.88-0.92, POD), i.e. the ability to detect unstable conditions, as in previous studies, but a much lower probability of null events (0.54-0.75, PON), i.e. the ability to detect stable conditions, with variation due to the binary classification of "Fair" stability as stable or unstable. Adding a 2 m test after an ECTP result lowered the POD (0.49-0.58), but substantially raised the PON (0.88-0.98) of the combined tests. The proportion of tests in agreement, i.e. ECTP and 2 m ECTP, increases with decreasing stability. We conclude that an ECTP followed by a 2 m ECTP is a clear red flag, indicating instability. The interpretation of an ECTP followed by a 2 m ECTN/X (no propagation) is not clear. Though this result suggests stability, a high potential for a false stable result means we cannot recommend the 2 m ECT for binary stability assessments. (C) 2015 Elsevier B.V. All rights reserved. C1 [Bair, Edward H.] Univ Calif Santa Barbara, Earth Res Inst, Santa Barbara, CA 93106 USA. [Bair, Edward H.] US Army Corps, Engineers Cold Reg Res & Engn Lab, Hanover, NH USA. [Simenhois, Ron] Coeur, Juneau, AK USA. [van Hervvijnen, Alec] WSL Inst Snow & Avalanche Res SLF, Davos, Switzerland. [Birkeland, Karl W.] US Forest Serv, Natl Avalanche Ctr, Bozeman, MT USA. RP Bair, EH (reprint author), Univ Calif Santa Barbara, 6832 Ellison Hall, Santa Barbara, CA 93106 USA. EM nbair@eri.ucsb.edu RI van Herwijnen, Alec/D-5768-2015 FU US Army Corps of Engineers Cold Regions Research and Engineering fellowship FX We thank two anonymous reviewers for their helpful comments. We thank Brandon Schwartz and Andy Anderson at the Sierra Avalanche Center, Sue Burak at the Eastern Sierra Avalanche Center, and Mike Janes at Alaska Electric Light and Power for their stability tests. The first author was partly supported by a US Army Corps of Engineers Cold Regions Research and Engineering fellowship administered by ORISE/ORAU. NR 20 TC 1 Z9 1 U1 0 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-232X EI 1872-7441 J9 COLD REG SCI TECHNOL JI Cold Reg. Sci. Tech. PD DEC PY 2015 VL 120 SI SI BP 191 EP 196 DI 10.1016/j.coldregions.2015.06.021 PG 6 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA CW5RX UT WOS:000365055400020 ER PT J AU Deems, JS Gadomski, PJ Vellone, D Evanczyk, R LeWinter, AL Birkeland, KW Finnegan, DC AF Deems, Jeffrey S. Gadomski, Peter J. Vellone, Dominic Evanczyk, Ryan LeWinter, Adam L. Birkeland, Karl W. Finnegan, David C. TI Mapping starting zone snow depth with a ground-based lidar to assist avalanche control and forecasting SO COLD REGIONS SCIENCE AND TECHNOLOGY LA English DT Article DE Spatial variability; Snow depth; Lidar; Avalanche; Avalanche control; Laser scanning ID SPATIAL VARIABILITY; SLOPES AB The distribution of snow depth in avalanche starting zones exerts a strong influence on avalanche potential and character. Extreme depth changes over short distances are common, especially in wind-affected, above-treeline environments. Snow depth also affects the ease of avalanche triggering. Experience shows that avalanche reduction efforts are often more successful when targeting shallow trigger point areas near deeper slabs with explosives or ski cutting. Our paper explores the use of high-resolution (cm scale) snow depth and snow depth change maps from terrestrial laser scanning (TLS) data to quantify loading patterns for use in both pre-control planning and in post-control assessment. We present results from a pilot study in three study areas at the Arapahoe Basin ski area in Colorado, USA. A snow-free reference data set was collected in a summer TLS survey. Mapping multiple times during the snow season allowed us to produce time series maps of snow depth and snow depth change at high resolution to explore depth and slab thickness variations due to wind redistribution. We conducted surveys before and after loading events and control work, allowing the exploration of loading patterns, slab thickness, shot and ski cut locations, bed surfaces, entrainment, and avalanche characteristics. We also evaluate the state of TLS for use in operational avalanche control settings. (C) 2015 Elsevier B.V. All rights reserved. C1 [Deems, Jeffrey S.] Univ Colorado, Natl Snow & Ice Data Ctr, UCB 449, Boulder, CO 80309 USA. [Gadomski, Peter J.; LeWinter, Adam L.; Finnegan, David C.] US Army Corps, Engineers Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Vellone, Dominic; Evanczyk, Ryan] Arapahoe Basin Ski Area, Dillon, CO 80435 USA. [Birkeland, Karl W.] US Forest Serv, USDA, Natl Avalanche Ctr, Bozeman, MT 59771 USA. RP Deems, JS (reprint author), Univ Colorado, Natl Snow & Ice Data Ctr, UCB 449, Boulder, CO 80309 USA. EM deems@nsidc.org RI Deems, Jeffrey/E-6484-2016 OI Deems, Jeffrey/0000-0002-3265-8670 FU CIRES Innovative Research Grant; Theo Meiners Research Grant from the American Avalanche Association FX We would like to acknowledge the Arapahoe Basin ski patrol, mountain operations, and management for enabling the data collection and collaborating towards operational integration. We are also grateful to Riegl Laser Measurement Systems GmbH for their innovation and leadership - their new long-range TLS systems make this project possible. Thanks to our two reviewers, whose comments and suggestions greatly improved this manuscript. This work was partially supported by a CIRES Innovative Research Grant, and by a Theo Meiners Research Grant from the American Avalanche Association - we are indebted to Theo for his energy and inspiration to incorporate new science and tools into operational avalanche decision-making. NR 25 TC 5 Z9 5 U1 2 U2 8 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-232X EI 1872-7441 J9 COLD REG SCI TECHNOL JI Cold Reg. Sci. Tech. PD DEC PY 2015 VL 120 SI SI BP 197 EP 204 DI 10.1016/j.coldregions.2015.09.002 PG 8 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA CW5RX UT WOS:000365055400021 ER PT J AU McBride, M Tran, P Pollard, KA Letowski, T McMillan, GP AF McBride, Maranda Tran, Phuong Pollard, Kimberly A. Letowski, Tomasz McMillan, Garnett P. TI Effects of Bone Vibrator Position on Auditory Spatial Perception Tasks SO HUMAN FACTORS LA English DT Article DE auditory perception; azimuth; bone conduction; localization; 3D ID LOCALIZATION PERFORMANCE; CONDUCTED SOUND; HEARING; AUDIO; DISPLAYS; SPEECH; IMPACT; LATERALIZATION; REVERBERATION; MASKING AB Objective: This study assessed listeners' ability to localize spatially differentiated virtual audio signals delivered by bone conduction (BC) vibrators and circumaural air conduction (AC) headphones. Background: Although the skull offers little intracranial sound wave attenuation, previous studies have demonstrated listeners' ability to localize auditory signals delivered by a pair of BC vibrators coupled to the mandibular condyle bones. The current study extended this research to other BC vibrator locations on the skull. Method: Each participant listened to virtual audio signals originating from 16 different horizontal locations using circumaural headphones or BC vibrators placed in front of, above, or behind the listener's ears. The listener's task was to indicate the signal's perceived direction of origin. Results: Localization accuracy with the BC front and BC top positions was comparable to that with the headphones, but responses for the BC back position were less accurate than both the headphones and BC front position. Conclusion: This study supports the conclusion of previous studies that listeners can localize virtual 3D signals equally well using AC and BC transducers. Based on these results, it is apparent that BC devices could be substituted for AC headphones with little to no localization performance degradation. Application: BC headphones can be used when spatial auditory information needs to be delivered without occluding the ears. Although vibrator placement in front of the ears appears optimal from the localization standpoint, the top or back position may be acceptable from an operational standpoint or if the BC system is integrated into headgear. C1 [McBride, Maranda] N Carolina Agr & Tech State Univ, Sch Business & Econ, Greensboro, NC 27411 USA. [Tran, Phuong; Pollard, Kimberly A.; Letowski, Tomasz] US Army Res Lab, Aberdeen, MD USA. [McMillan, Garnett P.] Natl Ctr Rehabil Auditory Res, VA Portland Hlth Care System, Portland, OR USA. RP McBride, M (reprint author), N Carolina Agr & Tech State Univ, Dept Management, 1301 E Market St, Greensboro, NC 27411 USA. EM mcbride@ncat.edu NR 42 TC 0 Z9 3 U1 1 U2 6 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0018-7208 EI 1547-8181 J9 HUM FACTORS JI Hum. Factors PD DEC PY 2015 VL 57 IS 8 BP 1443 EP 1458 DI 10.1177/0018720815596272 PG 16 WC Behavioral Sciences; Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology SC Behavioral Sciences; Engineering; Psychology GA CW5NN UT WOS:000365042600015 PM 26224085 ER PT J AU McWilliams, B Yu, J Pankow, M Yen, CF AF McWilliams, B. Yu, J. Pankow, M. Yen, C. -F. TI Ballistic impact behavior of woven ceramic fabric reinforced metal matrix composites SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE Metal matrix composites (MMCs); Impact behavior of composites; Finite element method; Dynamic failure mechanisms ID ALUMINUM-MATRIX; MECHANICAL RESPONSE; STRAIN-RATE; PERFORATION; MODEL; DEFORMATION; STRENGTH AB In this paper, the effect of weave architecture on the ballistic impact response of woven fabric metal matrix composites (MMC) is investigated. The ballistic limits, V-50(BL) of four different composites are experimentally determined and post impact characterization is used to investigate the damage mechanisms active during dynamic loading. Numerical modeling implementing an elastic plastic orthotropic material model with hydrostatic pressure dependent yield surface is used to model the pressure dependent response of the MMC during impact to predict the ballistic limit, and to offer insight into the damage mechanisms occurring during dynamic loading of woven fabric reinforced MMC. The correlation between laterally constrained compression testing and ballistic performance is investigated for use as a screening tool to enable rapid evaluation of the relative ballistic performance of potential fabric MMC weave and composite designs as a potential alternative to full scale ballistic testing. It was found that the fabric architecture has significant effect on ballistic performance and through thickness shear strength of the MMCs. It was found that 3D woven MMC is 13% and 40% lower in terms of ballistic limit and through thickness shear strength respectively, than its 2D counterpart. Furthermore, the numerical results successfully predict the ballistic limit of a 2D fabric reinforced MMC within 6% of the experiment and are used to qualitatively elucidate the experimentally observed damage mechanisms. Published by Elsevier Ltd. C1 [McWilliams, B.; Yu, J.; Yen, C. -F.] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD USA. [Pankow, M.] N Carolina State Univ, Dept Mech & Aerosp Engn, Raleigh, NC 27695 USA. RP McWilliams, B (reprint author), US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD USA. EM brandon.a.mcwilliams.civ@mail.mil; jian.h.yu.civ@mail.mil; mrpankow@ncsu.edu; chianfong.yen.civ@mail.mil NR 40 TC 2 Z9 3 U1 3 U2 11 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X EI 1879-3509 J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD DEC PY 2015 VL 86 BP 57 EP 66 DI 10.1016/j.ijimpeng.2015.07.005 PG 10 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA CX0CE UT WOS:000365363700005 ER PT J AU Sherburn, JA Roth, MJ Chen, JS Hillman, M AF Sherburn, Jesse A. Roth, Michael J. Chen, J. S. Hillman, Michael TI Meshfree modeling of concrete slab perforation using a reproducing kernel particle impact and penetration formulation SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE Reproducing kernel particle method; Meshfree; Concrete; Penetration; Damage mechanics ID SPHERICAL CAVITY-EXPANSION; CONFORMING NODAL INTEGRATION; CONTACT-IMPACT; NUMERICAL-INTEGRATION; COMPOSITE-MATERIALS; SURFACE-CONTACT; FINITE; MECHANICS; TARGETS; DAMAGE AB A meshfree formulation under the reproducing kernel particle method (RKPM) was introduced for modeling the penetration and perforation of brittle geomaterials such as concrete. RKPM provides a robust framework to effectively model the projectile-target interaction and the material failure and fragmentation behaviors that are critical for this class of problems. A stabilized semi-Lagrangian formulation, in conjunction with a multiscale material damage model for brittle geomaterials and a kernel contact algorithm, were introduced for penetration modeling. In this work, the accuracy of the meshfree impact and penetration formulation was studied using a series of large-caliber projectile concrete slab perforation experiments with impact velocities in the ballistic regime. These experiments were selected due to the challenging natute of concrete perforation, and the results were used to validate the effectiveness of the proposed method to model the penetration processes and the concrete target failure. Simulation results confirm the formulation's accuracy for this type of high-rate ballistic problem and establish a basis for extension to other types of impact problems. The results show the importance of properly formulating the method of domain integration to maintain accuracy in the presence of concrete fragmentation, and also highlight the method's ability to capture the fragmentation response without a need for non-physical treatments commonly used in conventional methods. Published by Elsevier Ltd. C1 [Sherburn, Jesse A.; Roth, Michael J.] US Army Engn Res & Dev Ctr, Vicksburg, MS USA. [Chen, J. S.; Hillman, Michael] Univ Calif San Diego, Dept Struct Engn, San Diego, CA 92103 USA. RP Sherburn, JA (reprint author), 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM jesse.a.sherburn@usace.army.mil FU U.S. Army Engineer Research and Development Center [W912HZ-07-C-0019] FX Permission to publish was granted by the Director, Geotechnical and Structures Laboratory, U.S. Army Engineer Research and Development Center. Simulations were partly performed on the Department of Defense Super Computing Resource high performance computers. Financial support from the U.S. Army Engineer Research and Development Center (Contract No. W912HZ-07-C-0019) to UCLA and its subcontract to UC San Diego is greatly acknowledged. NR 62 TC 1 Z9 1 U1 5 U2 9 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X EI 1879-3509 J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD DEC PY 2015 VL 86 BP 96 EP 110 DI 10.1016/j.ijimpeng.2015.07.009 PG 15 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA CX0CE UT WOS:000365363700008 ER PT J AU Vargas-Gonzalez, LR Gurganus, JC AF Vargas-Gonzalez, Lionel R. Gurganus, James C. TI Hybridized composite architecture for mitigation of non-penetrating ballistic trauma SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE Ultra-high molecular weight polyethylene; Non-penetrating ballistic impact; Impact stress; Composite laminate architecture; Blunt trauma ID MOLECULAR-WEIGHT POLYETHYLENE; DYNEEMA(R) COMPOSITES; FIBER COMPOSITES; MATERIAL MODEL; IMPACT; PERFORMANCE; SIMULATIONS AB Ultra-high molecular weight polyethylene (UHWMPE) fiber-based composites are employed in a variety of Soldier protection systems due to their impressive specific strength and elastic wave speed. However, as UHMWPE composites rely on their tenacity to decelerate the projectile impact, even in successfully arrested impacts issues arise with the blunt deformation trauma generated due to high deformation of the material into the Soldier. In this experiment, UHMWPE composite laminates employing two widely different laminate architectures, [0 degrees/90 degrees] and ARL X Hybrid, were evaluated to assess the effect of panel architecture on impact pressures generated in non-penetrating ballistic impact events. Panels were impacted with 7.62 mm lead core projectiles on a testing platform designed for the physics-based evaluation of BHBT of helmet materials. Composite panel deformation for the [0 degrees/90 degrees] configuration impacted the testing frame at velocities 2.2x higher than the ARL X Hybrid specimens, leading to a 526% higher average maximum pressure amplitude measured on the BHBT platform (45.5 +/- 19.1 MPa and 7.3 +/- 3.3 MPa for [0 degrees/90 degrees] and ARL X Hybrid, respectively), demonstrating the effectiveness of ARL X Hybrid in mitigating non-penetrating ballistic impact stress. The experiment has provided critical insight into non-penetrating small arms impact stresses and the role materials, materials processing, and materials design influence non-penetrating blunt trauma response. Published by Elsevier Ltd. C1 [Vargas-Gonzalez, Lionel R.; Gurganus, James C.] US Army, Res Lab, Mat Mfg & Sci Div, ATTN RDRL WMM D, Aberdeen Proving Ground, MD 21005 USA. RP Vargas-Gonzalez, LR (reprint author), US Army, Res Lab, Mat Mfg & Sci Div, ATTN RDRL WMM D, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA. EM lionel.r.vargas.civ@mail.mil OI Vargas-Gonzalez, Lionel/0000-0001-6500-1686 NR 40 TC 1 Z9 1 U1 5 U2 14 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X EI 1879-3509 J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD DEC PY 2015 VL 86 BP 295 EP 306 DI 10.1016/j.ijimpeng.2015.08.014 PG 12 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA CX0CE UT WOS:000365363700024 ER PT J AU Mao, HJ Unnikrishnan, G Rakesh, V Reifman, J AF Mao, Haojie Unnikrishnan, Ginu Rakesh, Vineet Reifman, Jaques TI Untangling the Effect of Head Acceleration on Brain Responses to Blast Waves SO JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME LA English DT Article DE blast-induced traumatic brain injury; head acceleration; brain pressure; finite-element model ID INJURY MODEL; SHOCK-WAVE; RAT; CAVITATION; MECHANISM; IMPACT; SKULL AB Multiple injury-causing mechanisms, such as wave propagation, skull flexure, cavitation, and head acceleration, have been proposed to explain blast-induced traumatic brain injury (bTBI). An accurate, quantitative description of the individual contribution of each of these mechanisms may be necessary to develop preventive strategies against bTBI. However, to date, despite numerous experimental and computational studies of bTBI, this question remains elusive. In this study, using a two-dimensional (2D) rat head model, we quantified the contribution of head acceleration to the biomechanical response of brain tissues when exposed to blast waves in a shock tube. We compared brain pressure at the coup, middle, and contre-coup regions between a 2D rat head model capable of simulating all mechanisms (i.e., the all-effects model) and an acceleration-only model. From our simulations, we determined that head acceleration contributed 36-45% of the maximum brain pressure at the coup region, had a negligible effect on the pressure at the middle region, and was responsible for the low pressure at the contre-coup region. Our findings also demonstrate that the current practice of measuring rat brain pressures close to the center of the brain would record only two-thirds of the maximum pressure observed at the coup region. Therefore, to accurately capture the effects of acceleration in experiments, we recommend placing a pressure sensor near the coup region, especially when investigating the acceleration mechanism using different experimental setups. C1 [Mao, Haojie; Unnikrishnan, Ginu; Rakesh, Vineet; Reifman, Jaques] US Army Med Res & Mat Command, US Dept Def, Software Applicat Inst, Telemed & Adv Technol Res Ctr,Biotechnol High Per, Ft Detrick, MD 21702 USA. RP Reifman, J (reprint author), US Army Med Res & Mat Command, US Dept Def, Software Applicat Inst, Telemed & Adv Technol Res Ctr,Biotechnol High Per, 504 Scott St, Ft Detrick, MD 21702 USA. EM jaques.reifman.civ@mail.mil FU U.S. Army Network Science Initiative; U.S. Department of Defense High Performance Computing Modernization Program; Defense Health Agency; NIH Grant [S10 RR23017]; U.S. Army Medical Research and Materiel Command, Fort Detrick, MD FX This research was supported by the U.S. Army Network Science Initiative, U.S. Army Medical Research and Materiel Command, Fort Detrick, MD, the U.S. Department of Defense High Performance Computing Modernization Program, and the Defense Health Agency. The rat head MRI images were acquired at the University of Utah Small Animal Imaging Facility on an instrument funded by NIH Grant No. S10 RR23017. The opinions and assertions contained herein are the private views of the authors and do not reflect the views of the U.S. Army or of the U.S. Department of Defense. NR 39 TC 0 Z9 0 U1 2 U2 6 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0148-0731 EI 1528-8951 J9 J BIOMECH ENG-T ASME JI J. Biomech. Eng.-Trans. ASME PD DEC PY 2015 VL 137 IS 12 AR 124502 DI 10.1115/1.4031765 PG 7 WC Biophysics; Engineering, Biomedical SC Biophysics; Engineering GA CW8SR UT WOS:000365270000012 PM 26458125 ER PT J AU Gandhi, V Bryant, DB Socolofsky, SA Stoesser, T Kim, JH AF Gandhi, Varun Bryant, Duncan B. Socolofsky, Scott A. Stoesser, Thorsten Kim, Jae-Hong TI Concentration-Based Decomposition of the Flow around a Confined Cylinder in a UV Disinfection Reactor SO JOURNAL OF ENGINEERING MECHANICS LA English DT Article ID PROPER ORTHOGONAL DECOMPOSITION; LASER-INDUCED FLUORESCENCE; TURBULENT CHANNEL FLOW; COHERENT STRUCTURES; CIRCULAR-CYLINDER; PIV DATA; WAKE; VISUALIZATION; DYNAMICS; POD AB The proper orthogonal decomposition (POD) is applied to spatial concentration data, obtained using laser-induced fluorescence (LIF), for the flow around a confined circular cylinder (R = 4; 900) and compared with their corresponding velocity and vorticity fields. The velocity, vorticity, and concentration modes identify the dominating coherent structures, i.e., shear layer rollup, instantaneous recirculation and von Karman vortex shedding. In the velocity and vorticity decomposition, instantaneous recirculation, and von Karman vortex shedding are represented in the highest energy modes. However, in the concentration decomposition, the most energetic modes represent the regions with strong concentration intermittency, i.e., where no dye is present, whereas the coherent structures, which are identified in the highest modes in the velocity and vorticity decomposition, are only found in the less energetic modes. The concentration-based decomposition identifies the shear layer around the cylinder, which is only partially captured by its vorticity-based counterpart. (c) 2015 American Society of Civil Engineers. C1 [Gandhi, Varun] Georgia Inst Technol, Sch Civil & Environm Engn, Atlanta, GA 30332 USA. [Bryant, Duncan B.] US Army, Engn Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. [Socolofsky, Scott A.] Texas A&M Univ, Zachry Dept Civil Engn, Coastal & Ocean Engn Div, College Stn, TX 77843 USA. [Stoesser, Thorsten] Cardiff Univ, Sch Engn, Cardiff CF24 3AA, S Glam, Wales. [Kim, Jae-Hong] Yale Univ, Sch Engn & Appl Sci, New Haven, CT 06511 USA. RP Stoesser, T (reprint author), Cardiff Univ, Sch Engn, Cardiff CF24 3AA, S Glam, Wales. EM stoesser@cf.ac.uk FU Water Research Foundation [4134]; Korea Water Resources Corporation (Kwater) FX This research was partially funded by Water Research Foundation (Project No. 4134) and Korea Water Resources Corporation (Kwater). NR 40 TC 0 Z9 0 U1 4 U2 4 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9399 EI 1943-7889 J9 J ENG MECH JI J. Eng. Mech. PD DEC PY 2015 VL 141 IS 12 AR UNSP 04015050 DI 10.1061/(ASCE)EM.1943-7889.0000959 PG 12 WC Engineering, Mechanical SC Engineering GA CW6RD UT WOS:000365124300005 ER PT J AU Pak, JH Fleming, M Scharffenberg, W Gibson, S Brauer, T AF Pak, Jang Hyuk Fleming, Matthew Scharffenberg, William Gibson, Stanford Brauer, Thomas TI Modeling Surface Soil Erosion and Sediment Transport Processes in the Upper North Bosque River Watershed, Texas SO JOURNAL OF HYDROLOGIC ENGINEERING LA English DT Article DE Hydrologic Engineering Center-Hydrologic Modeling System (HEC-HMS); Surface soil erosion; Reservoir siltation; Sediment transport ID UNCERTAINTY; BASINS AB A sediment transport module added to the Hydrologic Engineering Center's Hydrologic Modeling System (HEC-HMS) Version 4.0 computes surface erosion, reach routing, and reservoir trap efficiency. The HEC-HMS sediment transport module was applied to the Upper North Bosque River Watershed (UNBRW) in central Texas, a well-instrumented watershed with good parameterization and calibration data, to test model robustness. The UNBRW is 98% rural including rangeland, forage, and dairy waste application fields. Simulation results were compared to observed average daily total suspended solid (TSS) data at five gauge locations. The HEC-HMS results matched observed TSS across the UNBRW (<1% error at all gauges) during model calibration and maintained modest residuals (-31 to 12% error) during the validation period. The HEC-HMS also performed well compared to published results through two other commonly used models. (C) 2015 American Society of Civil Engineers. C1 [Pak, Jang Hyuk; Scharffenberg, William; Gibson, Stanford] US Army Corps Engineers, Inst Water Resources, Hydrol Engn Ctr, Davis, CA 95616 USA. [Fleming, Matthew] US Army Corps Engineers, Inst Water Resources, Hydrol Engn Ctr, Hydrol & Hydraul Technol Div, Davis, CA 95616 USA. [Brauer, Thomas] US Army Corps Engineers, Galveston, TX 77550 USA. RP Pak, JH (reprint author), US Army Corps Engineers, Inst Water Resources, Hydrol Engn Ctr, 609 Second St, Davis, CA 95616 USA. EM jay.h.pak@usace.army.mil FU System Wide Water Resources Program (SWWRP); Flood and Coastal Storm Damage Reduction Research and Development (RD) program of the U.S. Army Corps of Engineers FX Ann McFarland of the Texas Institute for Applied Environmental Research, Tarleton State University, is thanked for data support. The development of STM in HEC-HMS 4.0 was funded by the System Wide Water Resources Program (SWWRP) and Flood and Coastal Storm Damage Reduction Research and Development (RD) program of the U.S. Army Corps of Engineers. NR 48 TC 0 Z9 0 U1 7 U2 16 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1084-0699 EI 1943-5584 J9 J HYDROL ENG JI J. Hydrol. Eng. PD DEC PY 2015 VL 20 IS 12 AR UNSP 04015034 DI 10.1061/(ASCE)HE.1943-5584.0001205 PG 13 WC Engineering, Civil; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA CW6TD UT WOS:000365129800005 ER PT J AU Harbertson, J Scott, PT Moore, J Wolf, M Morris, J Thrasher, S D'Onofrio, M Grillo, MP Jacobs, MB Tran, BR Tian, J Ito, SI McAnany, J Michael, N Hale, BR AF Harbertson, Judith Scott, Paul T. Moore, John Wolf, Michael Morris, James Thrasher, Scott D'Onofrio, Michael Grillo, Michael P. Jacobs, Marni B. Tran, Bonnie R. Tian, Jun Ito, Stanley I. McAnany, Jennifer Michael, Nelson Hale, Braden R. TI Sexually transmitted infections and sexual behaviour of deploying shipboard US military personnel: a cross-sectional analysis SO SEXUALLY TRANSMITTED INFECTIONS LA English DT Article ID UNITED-STATES; CHLAMYDIAL INFECTION; DISEASES; RISK; TRANSMISSION; GONORRHEA; HIV; MEN; DETERMINANTS; PARTNERSHIPS AB Objectives Sexually transmitted infection (STI) prevalence and risk behaviour may differ at different phases of deployment. We examined STI prevalence and sexual behaviour in the predeployment time period (12 months prior) among recently deployed shipboard US Navy and Marine Corps military personnel. Methods Data were collected from 1938 male and 515 female service members through an anonymous, self-completed survey assessing sexual behaviours and STI acquisition characteristics in the past 12 months. Cross-sectional sex-stratified descriptive statistics are reported. Results Overall, 67% (n=1262/1896) reported last sex with a military beneficiary (spouse, n=931, non-spouse service member, n=331). Among those with a sexual partner outside their primary partnership, 24% (n=90/373) reported using a condom the last time they had sex and 30% (n=72/243) reported their outside partner was a service member. In total, 90% (n=210/233) reported acquiring their most recent STI in the USA (88%, n=126/143 among those reporting >= 1 deployments and an STI >= 1 year ago) and a significantly higher proportion (p<0.01) of women than men acquired the STI from their regular partner (54% vs 21%) and/or a service member (50% vs 26%). Conclusions Findings suggest a complex sexual network among service members and military beneficiaries. Findings may extend to other mobile civilian and military populations. Data suggest most STI transmission within the shipboard community may occur in local versus foreign ports but analyses from later time points in deployment are needed. These data may inform more effective STI prevention interventions. C1 [Harbertson, Judith; Scott, Paul T.; D'Onofrio, Michael; Tian, Jun; Michael, Nelson] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Harbertson, Judith; Tian, Jun] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Harbertson, Judith; Grillo, Michael P.; Jacobs, Marni B.; Tran, Bonnie R.; Ito, Stanley I.; McAnany, Jennifer; Hale, Braden R.] US Dept Def, HIV AIDS Prevent Program DHAPP, Naval Hlth Res Ctr, San Diego, CA USA. [Moore, John; Wolf, Michael; Morris, James; Thrasher, Scott] US Navy, San Diego, CA 92152 USA. [Hale, Braden R.] Univ Calif San Diego, Sch Med, Dept Med, Div Infect Dis, San Diego, CA 92103 USA. RP Harbertson, J (reprint author), Naval Hlth Res Ctr, US Mil HIV Res Program, 140 Sylvester Rd, San Diego, CA 92106 USA. EM judith.harbertson.ctr@mail.mil NR 28 TC 3 Z9 3 U1 2 U2 2 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1368-4973 EI 1472-3263 J9 SEX TRANSM INFECT JI Sex. Transm. Infect. PD DEC PY 2015 VL 91 IS 8 BP 581 EP 588 DI 10.1136/sextrans-2015-052163 PG 8 WC Infectious Diseases SC Infectious Diseases GA CW9UX UT WOS:000365344800012 PM 26586849 ER PT J AU Wasonga, C Inoue, S Rumberia, C Michuki, G Kimotho, J Ongus, JR Sang, R Musila, L AF Wasonga, Caroline Inoue, Shingo Rumberia, Cecilia Michuki, George Kimotho, James Ongus, Juliette R. Sang, Rosemary Musila, Lillian TI Genetic divergence of Chikungunya virus plaque variants from the Comoros Island (2005) SO VIRUS GENES LA English DT Article DE Chikungunya virus; Variants; Genetic variation; Comoros Island ID INDIAN-OCEAN OUTBREAK; ONYONG-NYONG VIRUSES; SRI-LANKA; INFECTION; SEROPREVALENCE; REEMERGENCE; SEQUENCE; MOSQUITO; GENOME AB Chikungunya virus (CHIKV) from a human sample collected during the 2005 Chikungunya outbreak in the Comoros Island, showed distinct and reproducible large (L2) and small (S7) plaques which were characterized in this study. The parent strain and plaque variants were analysed by in vitro growth kinetics in different cell lines and their genetic similarity assessed by whole genome sequencing, comparative sequence alignment and phylogenetic analysis. In vitro growth kinetic assays showed similar growth patterns of both plaque variants in Vero cells but higher viral titres of S7 compared to L2 in C6/36 cells. Amino acids (AA) alignments of the CHIKV plaque variants and S27 African prototype strain, showed 30 AA changes in the non-structural proteins (nsP) and 22 AA changes in the structural proteins. Between L2 and S7, only two AAs differences were observed. A missense substitution (C642Y) of L2 in the nsP2, involving a conservative AA substitution and a nonsense substitution (R524X) of S7 in the nsP3, which has been shown to enhance O'nyong-nyong virus infectivity and dissemination in Anopheles mosquitoes. The phenotypic difference observed in plaque size could be attributed to one of these AA substitutions. Phylogenetic analysis showed that the parent strain and its variants clustered closely together with each other and with Indian Ocean CHIKV strains indicating circulation of isolates with close evolutionary relatedness in the same outbreak. These observations pave way for important functional studies to understand the significance of the identified genetic changes in virulence and viral transmission in mosquito and mammalian hosts. C1 [Wasonga, Caroline] Univ Nairobi, Dept Biochem, Nairobi, Kenya. [Wasonga, Caroline; Sang, Rosemary] Kenya Med Res Inst KEMRI, Arbovirus Viral Haemorrhag Fever Lab, Nairobi, Kenya. [Kimotho, James] Kenya Med Res Inst KEMRI, Prod Dept, Nairobi, Kenya. [Inoue, Shingo] Nagasaki Univ, Inst Trop Med, Dept Virol, Nagasaki 8528523, Japan. [Rumberia, Cecilia; Michuki, George] Int Livestock Res Inst, Dept Biol Sci, Nairobi, Kenya. [Ongus, Juliette R.] Jomo Kenyatta Univ Agr & Technol, Med Lab Sci Dept, Nairobi, Kenya. [Ongus, Juliette R.] Int Ctr Insect Physiol & Ecol, Mol Biol & Bioinformat Unit, Nairobi, Kenya. [Musila, Lillian] United States Army, Dept Emerging Infect Dis, Med Res Unit Kenya, Nairobi, Kenya. RP Wasonga, C (reprint author), Univ Nairobi, Dept Biochem, POB 30197-00100, Nairobi, Kenya. EM cwasonga@gmail.com FU Consortium for National Health Research (CNHR), Kenya [RLG09-001/031]; Government of the Comoros Island FX The project was funded by the Consortium for National Health Research (CNHR), Kenya (Project Number RLG09-001/031). This study was also supported with reagents and equipment by JICA-JSPS Project and JICA-JST-SATREPS Project. We acknowledge the Biosciences Eastern and Central Africa - International Livestock Research Institute's (BecA-ILRI-Hub) genomics platform for supporting the sequencing work. We also appreciate the support given by the Government of the Comoros Island. This work was submitted with the permission of the Director, KEMRI, Nairobi, Kenya. NR 20 TC 0 Z9 0 U1 1 U2 5 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0920-8569 EI 1572-994X J9 VIRUS GENES JI Virus Genes PD DEC PY 2015 VL 51 IS 3 BP 323 EP 328 DI 10.1007/s11262-015-1243-4 PG 6 WC Genetics & Heredity; Virology SC Genetics & Heredity; Virology GA CW9PM UT WOS:000365330700001 PM 26347221 ER PT J AU Kirby, SD Norris, J Sweeney, R Bahnson, BJ Cerasoli, DM AF Kirby, Stephen D. Norris, Joseph Sweeney, Richard Bahnson, Brian J. Cerasoli, Douglas M. TI A rationally designed mutant of plasma platelet-activating factor acetylhydrolase hydrolyzes the organophosphorus nerve agent soman SO BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS LA English DT Article DE Nerve agents; Organophosphorus compounds; Plasma platelet-activating factor acetylhydrolase; Bioscavenger; Soman ID ANHYDRIDE HYDROLASE ACTIVITY; HUMAN BUTYRYLCHOLINESTERASE; CRYSTAL-STRUCTURES; COMPLEXES; PHOSPHOLIPASE-A2; TOXICITY; SARIN AB Organophosphorus compounds (Ups) such as satin and soman are some of the most toxic chemicals synthesized by man. They exert toxic effects by inactivating acetylcholinesterase (AChE) and bind secondary target protein. Organophosphorus compounds are hemi-substrates for enzymes of the serine hydrolase superfamily. Enzymes can be engineered by amino acid substitution into OP-hydrolyzing variants (bioscavengers) and used as therapeutics. Some enzymes associated with lipoproteins, such as human plasma platelet-activating factor acetylhydrolase (pPAF-AH), are also inhibited by OPs; these proteins have largely been ignored for engineering purposes because of complex interfacial kinetics and a lack of structural data. We have expressed active human pPAF-AH in bacteria and previously solved the crystal structure of this enzyme with OP adducts. Using these structures as a guide, we created histidine mutations near the active site of pPAF-AH (F322H, W298H, L153H) in an attempt to generate novel OP-hydrolase activity. Wild-type pPAF-AH, L153H, and F322H have essentially no hydrolytic activity against the nerve agents tested. In contrast, the W298H mutant displayed novel somanase activity with a k(cat) of 5 min(-1) and a K-M of 590 mu M at pH 7.5. There was no selective preference for hydrolysis of any of the four soman stereoisomers. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license. C1 [Kirby, Stephen D.; Norris, Joseph; Sweeney, Richard; Cerasoli, Douglas M.] US Army, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. [Kirby, Stephen D.; Bahnson, Brian J.] Univ Delaware, Dept Chem & Biochem, Newark, DE 19716 USA. RP Kirby, SD (reprint author), US Army, Med Res Inst Chem Def, Div Res, Physiol & Immunol Branch, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM stephen.d.kirby.civ@mail.mil FU Defense Threat Reduction Agency Joint Science and Technology Office, Medical ST Division; NIH from the National Institute of General Medical Sciences [8P30GM103519]; National Heart, Lung, and Blood Institute [5R01HL084366] FX This research was supported by the Defense Threat Reduction Agency Joint Science and Technology Office, Medical S&T Division. Funding was also obtained from NIH grants 8P30GM103519 from the National Institute of General Medical Sciences, and 5R01HL084366 from the National Heart, Lung, and Blood Institute to B.J.B. The views expressed in this manuscript are those of the authors and do not reflect the official policy of the Department of Army, Department of Defense, or the US. Government. NR 21 TC 2 Z9 2 U1 2 U2 10 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1570-9639 EI 0006-3002 J9 BBA-PROTEINS PROTEOM JI BBA-Proteins Proteomics PD DEC PY 2015 VL 1854 IS 12 BP 1809 EP 1815 DI 10.1016/j.bbapap.2015.09.001 PG 7 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA CW3KJ UT WOS:000364890900001 PM 26343853 ER PT J AU Getter, DJ Davidson, MT Consolazio, GR Patev, RC AF Getter, Daniel J. Davidson, Michael T. Consolazio, Gary R. Patev, Robert C. TI Determination of hurricane-induced barge impact loads on floodwalls using dynamic finite element analysis SO ENGINEERING STRUCTURES LA English DT Article DE Barge; Hurricane; Flood wall; Finite element impact simulation; Impact loads AB During hurricane events, moored barges are at risk of being propelled by high winds and impacting flood protection walls in the vicinity. Cities like New Orleans, Louisiana are at particular risk for such hazards, due to the preponderance of canals and moored barges throughout the city combined with high hurricane risk. Unfortunately, limited information is available to estimate the magnitude of barge impact loads for the design of floodwalls. In this paper, forces associated with hurricane-wind-propelled barge impacts on floodwalls are quantified using high-resolution dynamic finite element simulations. Such simulations account for highly nonlinear material deformation in the impacting barge, nonlinear soil response, and dynamic interaction between the barge, wall, and soil. The paper presents force histories for a variety of representative impact scenarios which can be used directly in dynamic analysis of floodwalls. Additional guidance is provided for employing the force results in static design scenarios. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Getter, Daniel J.; Davidson, Michael T.; Consolazio, Gary R.] Univ Florida, Dept Civil & Coastal Engn, Engn Sch Sustainable Infrastruct & Environm, Gainesville, FL 32611 USA. [Patev, Robert C.] US Army, Risk Management Ctr, Corps Engineers, Concord, MA 01742 USA. RP Consolazio, GR (reprint author), Univ Florida, Dept Civil & Coastal Engn, Engn Sch Sustainable Infrastruct & Environm, PO 116580, Gainesville, FL 32611 USA. EM grc@ufl.edu FU National Science Foundation Graduate Research Fellowship; [674-01-0198-13]; [W912P8-07-D-0054] FX This work was supported under subcontract to Digital Engineering and Imaging Inc., Contract No. 674-01-0198-13, which was under prime contract to the U.S. Army Corps of Engineers, Contract No. W912P8-07-D-0054. Portions of this work were also supported by a National Science Foundation Graduate Research Fellowship. The authors would like to extend thanks to Dr. Patrick Hudson (Moment Engineering) and Dr. Michael McCormick (U.S. Naval Academy) for their contributions to the overall effort of which this work is only part. The authors also thank Mr. Zachary Harper, Mr. Falak Shah, and Mr. Robert Hendrix for their contributions to modeling, simulation, and data processing. NR 22 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0141-0296 EI 1873-7323 J9 ENG STRUCT JI Eng. Struct. PD DEC 1 PY 2015 VL 104 BP 95 EP 106 DI 10.1016/j.engstruct.2015.09.021 PG 12 WC Engineering, Civil SC Engineering GA CW3LV UT WOS:000364894700007 ER PT J AU Reale, JK Van Horn, DJ Condon, KE Dahm, CN AF Reale, Justin K. Van Horn, David J. Condon, Katherine E. Dahm, Clifford N. TI The effects of catastrophic wildfire on water quality along a river continuum SO FRESHWATER SCIENCE LA English DT Article DE water quality; forest fire; continuous monitoring; river continuum; disturbance; dissolved oxygen; turbidity; specific conductance ID WESTERN NORTH-AMERICA; INTERANNUAL VARIATION; ECOSYSTEM METABOLISM; FOREST CATCHMENTS; STREAM ECOSYSTEMS; BOREAL FOREST; NEW-MEXICO; FIRE; SEDIMENT; NUTRIENT AB To further our understanding of the linkages among wildfire, streamflow pathways, and water chemistry, we used a network of water-quality sensors and streamflow gages to assess initial and long-term effects of wildfire along a river continuum. We assessed water quality of a 2nd- and a 4th-order stream in a single watershed for 5 monsoon seasons before, during, and after a catastrophic wildfire. Fire had significant and sustained long-term effects on both streams. In the 2nd-order stream, variability in dissolved O-2 (DO) increased after the fire. Daily total precipitation was unchanged, but episodic storm events resulted in significant increases in stream discharge that led to elevated turbidity and specific conductance (SC). In the 4th-order stream, fire led to minimal measurable effects on turbidity, elevated SC, and greater variability of the DO signal. We also assessed water-quality data from 4 sites along the river continuum for a 4-mo period before, during, and after the wildfire. Large overland and debris-flow events in the 1st- and 2nd-order streams resulted in elevated particles (e.g., soil, sediment, rock, ash, plant biomass) and solutes in transport that elevated turbidity and SC and damped the DO signal. We documented less severe postfire effects in the 3rd-order stream probably because of groundwater contributions and a higher stream gradient with a pool-riffle geomorphology. We observed nominal changes in turbidity, strong SC spikes, and strong DO decreases in the 4th-order stream. Streamflow pathways, geomorphology, physiochemical properties, and biogeochemical processes play a central role in the postfire water-quality response along the river continuum. Our findings highlight the importance of collecting water-quality measurements at temporal and spatial scales that effectively capture hydrological dynamics. C1 [Reale, Justin K.; Van Horn, David J.; Dahm, Clifford N.] Univ New Mexico, Dept Biol, Albuquerque, NM 87131 USA. [Reale, Justin K.] US Army Corps Engineers, Albuquerque, NM 87109 USA. [Condon, Katherine E.] Valles Caldera Natl Preserve, Jemez Springs, NM 87025 USA. RP Reale, JK (reprint author), Univ New Mexico, Dept Biol, Albuquerque, NM 87131 USA. EM justin.k.reale@usace.army.mil; vanhorn@unm.edu; kcondon@vallescaldera.gov; cdahm@sevilleta.unm.edu FU USACE, Albuquerque District; National Science Foundation [EAR-0724958, EAR-1331408]; New Mexico Experimental Program [0814449]; Sevilleta Long-Term Ecological Research (LTER) Program [DEB 0620482] FX We acknowledge Susan Bittick, Cecilia Horner, Amy Louise, and Chelsea Reale from the US Army Corps of Engineers (USACE), Albuquerque District for their support and assistance. David Soballe (USACE, Engineer Research and Development Center), Lee Brown (Guest Editor), and 2 anonymous referees greatly improved the manuscript. Robert Parmenter and Scott Compton of the VCNP provided logistical support and long-term data. We also thank current and former members of the Hydrogeoecology group at the University of New Mexico. The USACE, Albuquerque District, provided support for this program and salary for JKR. The USGS NM Water Science Center and cooperators provided discharge and water quality data. The National Science Foundation provided support for this project to the Catalina-Jemez Critical Zone Observatory (grant EAR-0724958 and EAR-1331408), the New Mexico Experimental Program to Stimulate Competitive Research RII Track I Project (award 0814449), and the Sevilleta Long-Term Ecological Research (LTER) Program (award DEB 0620482). This is publication SEV716 from the Sevilleta LTER Project. Any use of trade, firm, or product names is for descriptive purposes only and does not imply endorsement by the US Government. The findings and conclusions in this article are those of the authors and do not necessarily represent the views of the US Government. NR 84 TC 4 Z9 4 U1 15 U2 40 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 2161-9549 EI 2161-9565 J9 FRESHW SCI JI Freshw. Sci. PD DEC PY 2015 VL 34 IS 4 BP 1426 EP 1442 DI 10.1086/684001 PG 17 WC Ecology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA CW2IM UT WOS:000364815000019 ER PT J AU Piccirillo, AL Packnett, ER Boivin, MR Cowan, DN AF Piccirillo, Amanda L. Packnett, Elizabeth R. Boivin, Michael R. Cowan, David N. TI Epidemiology of psychiatric disability without posttraumatic stress disorder among US Army and Marine Corps personnel evaluated for disability discharge SO JOURNAL OF PSYCHIATRIC RESEARCH LA English DT Article DE Military psychiatry; Epidemiology; Disability ID TRAUMATIC BRAIN-INJURY; MENTAL-HEALTH PROBLEMS; MILITARY PERSONNEL; IRAQ; AFGHANISTAN; DEPLOYMENT; VETERANS; SOLDIERS; SERVICE; COMBAT AB Psychiatric disorders are a common reason for disability discharge from the U.S. military. Research on psychiatric disorders in military personnel evaluated for disability discharge has historically focused on posttraumatic stress disorder (PTSD), yet 40% of service members evaluated for a psychiatric-related disability do not have PTSD. This study's objective was to describe characteristics and correlates of disability in Army and Marine Corps personnel diagnosed with psychiatric disorders other than PTSD. In this cross-sectional study, the chi-square and Wilcoxon Mann Whitney tests compared the distribution of demographic, disability and deployment characteristics between those evaluated for non-PTSD psychiatric disability (N = 9125) versus those evaluated for any other non-psychiatric condition (N = 78,072). Multivariate logistic regression examined associations between disability retirement and demographic and disability characteristics. Results show a significantly higher prevalence of disability retirement, deployment, and comorbidity among Army and Marine Corps personnel evaluated for disability discharge related to a non-PTSD psychiatric disorder. Mood disorders, anxiety disorders and dementia were the most commonly evaluated psychiatric disorders. Characteristics associated with increased odds of non-PTSD psychiatric-related disability retirement includes being in the Marine Corps (OR = 1.24), being black (OR = 1.29) or other race (OR = 133), having a combat-related condition (OR = 2.50), and older age. Service members evaluated for a non-PTSD psychiatric disability have similar rates of disability retirement as those evaluated for PTSD, suggesting non-PTSD psychiatric disorders cause a severe and highly compensated disability. Additional research is needed describing the epidemiology of specific non-PTSD psychiatric disorders, such as depression, in service members evaluated for disability discharge. (c) 2015 Elsevier Ltd. All rights reserved. C1 [Piccirillo, Amanda L.; Packnett, Elizabeth R.; Boivin, Michael R.; Cowan, David N.] Walter Reed Army Inst Res, Dept Epidemiol, Prevent Med Branch, Silver Spring, MD 20910 USA. [Piccirillo, Amanda L.; Packnett, Elizabeth R.; Cowan, David N.] ManTech Int Corp, Hlth & Life Sci, Herndon, VA 20171 USA. RP Piccirillo, AL (reprint author), Walter Reed Army Inst Res, Prevent Med Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM amanda.l.piccirillo.ctr@mail.mil FU Defense Health Program FX This study was supported by funds provided by the Defense Health Program. NR 37 TC 0 Z9 0 U1 1 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-3956 EI 1879-1379 J9 J PSYCHIATR RES JI J. Psychiatr. Res. PD DEC PY 2015 VL 71 BP 56 EP 62 DI 10.1016/j.jpsychires.2015.09.010 PG 7 WC Psychiatry SC Psychiatry GA CW5RI UT WOS:000365053900007 PM 26522872 ER PT J AU Clark, ME Woo, RK Johnson, SM AF Clark, Margaret E. Woo, Russell K. Johnson, Sidney M. TI Thoracoscopic pleural clipping for the management of congenital chylothorax SO PEDIATRIC SURGERY INTERNATIONAL LA English DT Article DE Chylothorax; Chyle leak; Thoracic duct; Neonate; Parietal clipping; Pleurodesis ID IDIOPATHIC CHYLOTHORAX; THORACIC-DUCT; EFFUSIONS; LIGATION AB Medical management of congenital chylothoraces consists of total parental nutrition and tube thoracostomy. However, these infants are exposed to significant fluid shifts and the related leukopenia carries a high infection risk. The purpose of this review is to describe the technique of parietal pleural clipping as a surgical treatment of congenital chylothorax. The medical records of all patients with a chylothorax diagnosis during the study period of January 2002 to April 2014 were retrospectively reviewed. Six of 14 infants identified underwent thoracoscopic parietal pleural clipping to disrupt the pleural lymphatic channel flow as visualization of the thoracic duct and lymphatics was not possible. Nearly all surgical patients had bilateral disease (5/6). Resolution of chylous leakage was dramatic following parietal clipping. In the surgical patients, chest tube output 2 days prior to surgery averaged 86.96 ml/kg/day. After parietal clipping, chest tube output dropped to an average of 6.5 ml/kg/day on post op day 2. Thereafter, chest tube output remained low to negligible and chest tubes were removed variably as enteral feeds were started. We describe a straightforward technique of thoracoscopic parietal pleural clipping as a safe and successful option for treatment of congenital chylothoraces. C1 [Clark, Margaret E.] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. [Woo, Russell K.; Johnson, Sidney M.] Univ Hawaii, Kapiolani Med Ctr, Dept Pediat Surg, Honolulu, HI 96822 USA. RP Clark, ME (reprint author), Tripler Army Med Ctr, Dept Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM margaret.elise.clark@gmail.com NR 15 TC 0 Z9 1 U1 2 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0179-0358 EI 1437-9813 J9 PEDIATR SURG INT JI Pediatr. Surg. Int. PD DEC PY 2015 VL 31 IS 12 BP 1133 EP 1137 DI 10.1007/s00383-015-3760-6 PG 5 WC Pediatrics; Surgery SC Pediatrics; Surgery GA CW6BL UT WOS:000365081900004 PM 26276425 ER PT J AU Crone, JC Munday, LB Knap, J AF Crone, Joshua C. Munday, Lynn B. Knap, Jaroslaw TI Capturing the effects of free surfaces on void strengthening with dislocation dynamics SO ACTA MATERIALIA LA English DT Article DE Discrete dislocation dynamics; Void strengthening; Surface effects ID CENTERED-CUBIC METALS; SIMULATIONS; FCC; MECHANISMS; CRYSTALS; STRESS; MODEL; IRON; DRAG; BCC AB Void strengthening in crystalline materials refers to the increase in yield stress due to the impediment of dislocation motion by voids. Dislocation dynamics (DD) is a modeling method well suited to capture the physics, length scales, and time scales associated with void strengthening. However, previous DD simulation of dislocation void interactions have been unable to accurately account for the strong image forces acting on the dislocation due to the void's free surface. In this article, we employ a finite-element-based DD method to determine the obstacle strength of voids, defined as the critical resolved shear stress for a dislocation to glide past an array of voids. Our results demonstrate that the attractive image forces between the dislocation and free surface significantly reduce the obstacle strength of voids. Effects of surface mobility and stress concentrations around the void are also explored and are shown to have minimal effect on the critical stress. Finally, a new model relating void size and spacing to obstacle strength is proposed. Published by Elsevier Ltd. on behalf of Acta Materialia Inc. C1 [Crone, Joshua C.; Munday, Lynn B.; Knap, Jaroslaw] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Crone, JC (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM joshua.crone.civ@mail.mil FU U.S. Army Research Laboratory's Enterprise for Multiscale Research of Materials FX Support of the U.S. Army Research Laboratory's Enterprise for Multiscale Research of Materials is gratefully acknowledged. Computing support was provided by the DoD Supercomputing Resource Center located at the U.S. Army Research Laboratory. NR 36 TC 3 Z9 3 U1 0 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6454 EI 1873-2453 J9 ACTA MATER JI Acta Mater. PD DEC PY 2015 VL 101 BP 40 EP 47 DI 10.1016/j.actamat.2015.08.067 PG 8 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA CV4RN UT WOS:000364254300006 ER PT J AU Booth, DB Fischenich, CJ AF Booth, Derek B. Fischenich, Craig J. TI A channel evolution model to guide sustainable urban stream restoration SO AREA LA English DT Article DE urban streams; channel evolution models; restoration; sustainability; geomorphology ID SOUTHERN CALIFORNIA; RIPARIAN-CORRIDOR; RIVER; URBANIZATION; WATERSHEDS; EROSION; USA; HYDROMODIFICATION; REHABILITATION; CLASSIFICATION AB Channel evolution models (CEMs) are used to structure the interpretation of observed channel morphology to support long-term restoration of these systems. However, channels reflect the variety of their watersheds' climatological, ecological and physiographic contexts, and so no single CEM can be truly global'. Unrecognised differences between the assumptions and the reality of evolutionary trajectories of particular streams can subsequently lead to restoration actions that neither fully achieve their intended objectives nor successfully self-maintain even limited improvements. Despite the daunting variety of biophysical settings, however, urbanisation imposes distinctive, homogenising influences on virtually all watercourses, suggesting that even a relatively small set of evolutionary pathways can embrace much of the diversity of critical watershed drivers on urban channels. CEMs describing single-thread channel response to incision are most common in the published literature, but not every urban disturbance yields this classic sequence, initiated by excess transport capacity followed by incision, bank erosion, widening and ultimately a lowered re-equilibrated channel. A comprehensive urban CEM must also include responses under less common (but locally ubiquitous) conditions, such as excess sediment relative to transport capacity (the inverse' of the classic CEM), imposed constraints on vertical and/or lateral adjustment, and multi-thread channels or those influenced by instream or riparian vegetation. An urban CEM also requires a hierarchical framework that acknowledges fundamental differences in the process drivers within any given watershed, because a single observation of channel form can rarely pinpoint the context or evolutionary trajectory of every stream. We present a geomorphic framework for diagnosing and predicting the evolution of urban streams, potentially guiding the selection of restoration targets that are achievable within an urban context and sustainable without ongoing maintenance. C1 [Booth, Derek B.] Univ Calif Santa Barbara, Bren Sch Environm Sci & Management, Santa Barbara, CA 93106 USA. [Fischenich, Craig J.] US Army Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Booth, DB (reprint author), Univ Calif Santa Barbara, Bren Sch Environm Sci & Management, Santa Barbara, CA 93106 USA. EM dbooth@bren.ucsb.edu FU Ecosystem Management and Restoration Research Program through US Army Corps of Engineers [W912HZ-12-2-0016]; Ecosystem Management and Restoration Research Program through UC Santa Barbara [W912HZ-12-2-0016] FX Our thanks to colleagues Sarah Miller, Jock Cunningham, Dan Baker and five anonymous journal reviewers whose suggestions greatly improved the quality of this paper. This work was supported under the Ecosystem Management and Restoration Research Program through Cooperative Agreement W912HZ-12-2-0016 between the US Army Corps of Engineers and UC Santa Barbara. NR 56 TC 6 Z9 6 U1 8 U2 31 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0004-0894 EI 1475-4762 J9 AREA JI Area PD DEC PY 2015 VL 47 IS 4 BP 408 EP 421 DI 10.1111/area.12180 PG 14 WC Geography SC Geography GA CV9YJ UT WOS:000364644500007 ER PT J AU Holloway, TL Rani, M Cap, AP Stewart, RM Schwacha, MG AF Holloway, Travis L. Rani, Meenakshi Cap, Andrew P. Stewart, Ronald M. Schwacha, Martin G. TI The association between the Th-17 immune response and pulmonary complications in a trauma ICU population SO CYTOKINE LA English DT Article DE Acute lung injury; IL-17; Acute respiratory distress syndrome; Inflammation; Injury ID ACUTE LUNG INJURY; RESPIRATORY-DISTRESS-SYNDROME; IL-17 FAMILY CYTOKINES; CELL LINEAGES; T-CELL; INFLAMMATION; EXPRESSION AB Background: The overall immunopathology of the T-helper cell (Th)-17 immune response has been implicated in various inflammatory diseases including pulmonary inflammation; however its potential role in acute respiratory distress syndrome (ARDS) is not defined. This study aimed to evaluate the Th-17 response in bronchoalveolar lavage fluid (BALF) and blood and from trauma patients with pulmonary complications. Methods: A total of 21 severely injured intensive care unit (ICU) subjects, who were mechanically ventilated and undergoing bronchoscopy, were enrolled. BALF and blood were collected and analyzed for Th-1 (interferon [IFN]gamma), Th-2 (interleukin [IL]-4, -10), Th-17 (IL-17A, -17F, -22, 23) and pro-inflammatory (IL-1 beta, IL-6, tumor necrosis factor [TNF]alpha) cytokine levels. Results: Significant levels of the Th-17 cytokines IL-17A, -17F and -21 and IL-6 (which can be classified as a Th-17 cytokine) were observed in the BALF of all subjects. There were no significant differences in Th-17 cytokines between those subjects with ARDS and those without, with the exception of plasma and BALE IL-6, which was markedly greater in ARDS subjects, as compared with controls and non-ARDS subjects. Conclusions: Trauma patients with pulmonary complications exhibited a significant Th-17 response in the lung and blood, suggesting that this pro-inflammatory milieu may be a contributing factor to such complications. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Holloway, Travis L.; Rani, Meenakshi; Stewart, Ronald M.; Schwacha, Martin G.] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX 78229 USA. [Cap, Andrew P.; Schwacha, Martin G.] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Schwacha, MG (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, Mail Code 7740,7703 Floyd Curl Dr, San Antonio, TX 78229 USA. EM schwacha@uthscsa.edu FU UTHSCSA Department of Surgery NIH T32 Training Grant NIH Grant [5T32GM079085]; NIH/NCRR UL [1RR025767]; NIH-NCI [P30 CA54174]; [UL1RR025767] FX TLH was supported under the UTHSCSA Department of Surgery NIH T32 Training Grant NIH Grant (5T32GM079085) and the project was in part supported by NIH/NCRR UL 1RR025767, NIH-NCI P30 CA54174 and UL1RR025767. NR 31 TC 2 Z9 2 U1 0 U2 2 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 1043-4666 EI 1096-0023 J9 CYTOKINE JI Cytokine PD DEC PY 2015 VL 76 IS 2 BP 328 EP 333 DI 10.1016/j.cyto.2015.09.003 PG 6 WC Biochemistry & Molecular Biology; Cell Biology; Immunology SC Biochemistry & Molecular Biology; Cell Biology; Immunology GA CV4NS UT WOS:000364244400028 PM 26364992 ER PT J AU Kore, I Ananworanich, J Valcour, V Fletcher, JLK Chalermchai, T Paul, R Reynolds, J Tipsuk, S Ubolyam, S Rattanamanee, S Jagodzinski, L Kim, J Spudich, S AF Kore, Idil Ananworanich, Jintanat Valcour, Victor Fletcher, James L. K. Chalermchai, Thep Paul, Robert Reynolds, Jesse Tipsuk, Somporn Ubolyam, Sasiwimol Rattanamanee, Somprartthana Jagodzinski, Linda Kim, Jerome Spudich, Serena CA RV254 SEARCH 010 Study Grp TI Neuropsychological Impairment in Acute HIV and the Effect of Immediate Antiretroviral Therapy SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE HIV infection; HIV-associated neurocognitive disorder; neuropsychological tests; mild cognitive impairment; antiretroviral therapy ID NEUROCOGNITIVE IMPAIRMENT; INFECTED PERSONS; PREVALENCE; DISORDERS; ERA; RISK; PERFORMANCE; NADIR AB Objective:To investigate neuropsychological performance (NP) during acute HIV infection (AHI) before and after combination antiretroviral therapy (cART). Design: Prospective study of Thai AHI participants examined at 3 and 6 months after initiation of cART. Methods: Thirty-six AHI participants were evaluated pre-cART at median 19 days since HIV exposure and 3 and 6 months after cART with the Grooved Pegboard test, Color Trails 1 & 2 (CT1, CT2), and Trail Making Test A. Raw scores were standardized to 251 age- and education-matched HIV-uninfected Thais. To account for learning effects, change in NP performance was compared with that of controls at 6 months. Analyses included multivariable regression, nonparametric repeated measures analysis of variance, and Mann-Whitney U test. Results: Baseline NP scores for the AHI group were within normal range (z-scores range: -0.26 to -0.13). NP performance improved on CT1, CT2, and Trail Making Test A in the initial 3 months (P < 0.01) with no significant change during the last 3 months. Only improvement in CT1 was greater than that seen in controls at 6 months (P = 0.018). Participants who performed >1 SD below normative means on 2 tests (n = 8) exhibited higher baseline cerebrospinal fluid HIV RNA (P = 0.047) and had no improvement after cART. Conclusions: Most AHI individuals had normal NP performance, and early cART slightly improved their psychomotor function. However, approximately 25% had impaired NP performance, which correlated with higher cerebrospinal fluid HIV RNA, and these abnormalities were not reversed by early cART possibly indicating limited reversibility of cognitive impairment in a subset of AHI individuals. C1 [Kore, Idil; Spudich, Serena] Yale Univ, Sch Med, New Haven, CT 06520 USA. [Ananworanich, Jintanat; Fletcher, James L. K.; Chalermchai, Thep; Tipsuk, Somporn; Rattanamanee, Somprartthana; Kim, Jerome] Thai Red Cross AIDS Res Ctr, SEARCH, Bangkok, Thailand. [Ananworanich, Jintanat; Jagodzinski, Linda; Kim, Jerome] US Mil HIV Res Program, Walter Reed Army Inst Res, Silver Spring, MD USA. [Ananworanich, Jintanat; Jagodzinski, Linda; Kim, Jerome] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Valcour, Victor] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Paul, Robert] Univ Missouri, Missouri Inst Mental Hlth, St Louis, MO 63121 USA. [Reynolds, Jesse] Yale Ctr Analyt Sci, New Haven, CT USA. [Ubolyam, Sasiwimol] Thai Red Cross AIDS Res Ctr, HIV NAT, Bangkok, Thailand. RP Spudich, S (reprint author), Yale Univ, Dept Neurol, POB 208018, New Haven, CT 06520 USA. EM serena.spudich@yale.edu FU National Institutes of Health [R01MH095613, R21MH086341, R01MH09561302-S1, R01NS061696]; US Military HIV Research Program, Walter Reed Army Institute of Research, Rockville, MD [W81XWH-07-2-0067]; Yale School of Medicine Office of Student Research; Thai Government Pharmaceutical Organization; Gilead; Merck; ViiV Healthcare; [R01MH09561302- S1] FX S.S. has received travel support and an honorarium for presentation at a scientific meeting from Abbvie, Inc. These studies were funded by the National Institutes of Health (R01MH095613, R21MH086341, R01MH09561302-S1, R01NS061696) and the US Military HIV Research Program, Walter Reed Army Institute of Research, Rockville, MD, under a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the US Department of Defense. I.K. was directly supported by R01MH09561302- S1 and the Yale School of Medicine Office of Student Research. Antiretrovirals were supported by the Thai Government Pharmaceutical Organization, Gilead, Merck, and ViiV Healthcare. Monogram Biosciences supported the Trofile test. The content of this presentation is solely the responsibility of the authors and does not necessarily represent the official views of any of the institutions mentioned above. NR 31 TC 6 Z9 6 U1 2 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1525-4135 EI 1077-9450 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD DEC 1 PY 2015 VL 70 IS 4 BP 393 EP 399 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA CV5MZ UT WOS:000364316300009 PM 26509933 ER PT J AU Hakre, S Scoville, SL Pacha, LA Peel, SA Kim, JH Michael, NL Cersovsky, SB Scott, PT AF Hakre, Shilpa Scoville, Stephanie L. Pacha, Laura A. Peel, Sheila A. Kim, Jerome H. Michael, Nelson L. Cersovsky, Steven B. Scott, Paul T. TI Sexual Risk Behaviors of HIV Seroconverters in the US Army, 2012-2014 SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE HIV; US Army; surveillance; MSM ID WHITE MEN; PARTNER SELECTION; BLACK; DISPARITIES; INFECTION; METAANALYSIS AB The United States (US) Army implemented a comprehensive HIV characterization program in 2012 following repeal of the Don't Ask, Don't Tell policy banning openly homosexual individuals from serving in the US military. Program staff administered a standardized case report form to soldiers newl