FN Thomson Reuters Web of Science™
VR 1.0
PT J
AU Rettinger, CL
Fletcher, JL
Carlsson, AH
Leung, KP
Chan, RK
AF Rettinger, C. L.
Fletcher, J. L.
Carlsson, A. H.
Leung, K. P.
Chan, R. K.
TI IMPROVED WOUND HEALING PARAMETERS IN PORCINE FULL-THICKNESS WOUNDS
TRANSPLANTED WITH FULL-THICKNESS SKIN MICROGRAFTS
SO WOUND REPAIR AND REGENERATION
LA English
DT Meeting Abstract
C1 [Rettinger, C. L.; Fletcher, J. L.; Carlsson, A. H.; Leung, K. P.; Chan, R. K.] US Army Inst Surg Res, Dent & Trauma Res Directorate, Ft Sam Houston, TX USA.
NR 0
TC 0
Z9 0
U1 2
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAR-APR
PY 2016
VL 24
IS 2
BP A22
EP A22
PG 1
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA DK8DP
UT WOS:000375157700094
ER
PT J
AU Brennan, LM
Widder, MW
McAleer, MK
Mayo, MW
Greis, AP
van der Schalie, WH
AF Brennan, Linda M.
Widder, Mark W.
McAleer, Michael K.
Mayo, Michael W.
Greis, Alex P.
van der Schalie, William H.
TI Preparation and Testing of Impedance-based Fluidic Biochips with
RTgill-W1 Cells for Rapid Evaluation of Drinking Water Samples for
Toxicity
SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
LA English
DT Article
DE Environmental Sciences; Issue 109; Fish cells; impedance; sensors;
biochip; water toxicity; ECIS; monolayer; field-portable
ID CYTOTOXICITY; BIOSENSORS
AB This manuscript describes how to prepare fluidic biochips with Rainbow trout gill epithelial (RTgill-W1) cells for use in a field portable water toxicity sensor. A monolayer of RTgill-W1 cells forms on the sensing electrodes enclosed within the biochips. The biochips are then used for testing in a field portable electric cell-substrate impedance sensing (ECIS) device designed for rapid toxicity testing of drinking water. The manuscript further describes how to run a toxicity test using the prepared biochips. A control water sample and the test water sample are mixed with pre-measured powdered media and injected into separate channels of the biochip. Impedance readings from the sensing electrodes in each of the biochip channels are measured and compared by an automated statistical software program. The screen on the ECIS instrument will indicate either "Contamination Detected" or "No Contamination Detected" within an hour of sample injection. Advantages are ease of use and rapid response to a broad spectrum of inorganic and organic chemicals at concentrations that are relevant to human health concerns, as well as the long-term stability of stored biochips in a ready state for testing. Limitations are the requirement for cold storage of the biochips and limited sensitivity to cholinesterase-inhibiting pesticides. Applications for this toxicity detector are for rapid field-portable testing of drinking water supplies by Army Preventative Medicine personnel or for use at municipal water treatment facilities.
C1 [Brennan, Linda M.; Widder, Mark W.; van der Schalie, William H.] US Army, Ctr Environm Hlth Res, Ft Detrick, MD 21702 USA.
[McAleer, Michael K.; Mayo, Michael W.; Greis, Alex P.] Nanohmics Inc, Austin, TX 78741 USA.
RP Brennan, LM (reprint author), US Army, Ctr Environm Hlth Res, Ft Detrick, MD 21702 USA.
EM linda.m.brennan2.civ@mail.mil
FU US Army Medical Research and Materiel Command; Small Business Innovation
Research and Small Business Technology Transfer program
[W81XWH-13-C-0093]
FX This work was supported by the US Army Medical Research and Materiel
Command and by the Small Business Innovation Research and Small Business
Technology Transfer program; Contract No. W81XWH-13-C-0093. We would
like to thank Dr. Lucy Lee at the University of Fraser for being our
RTgill-W1 cell culture mentor, and to acknowledge Dr. Niels Bols of
Waterloo University for the development of the RTgill-W1cell line.
NR 16
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U1 3
U2 3
PU JOURNAL OF VISUALIZED EXPERIMENTS
PI CAMBRIDGE
PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA
SN 1940-087X
J9 JOVE-J VIS EXP
JI J. Vis. Exp.
PD MAR
PY 2016
IS 109
AR e53555
DI 10.3791/53555
PG 8
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DK0XR
UT WOS:000374636300023
ER
PT J
AU Austin, KG
Farina, EK
Lieberman, HR
AF Austin, Krista G.
Farina, Emily K.
Lieberman, Harris R.
TI Self-reported side-effects associated with use of dietary supplements in
an armed forces population
SO DRUG TESTING AND ANALYSIS
LA English
DT Article
DE protein supplements; combination products; body mass index; physical
fitness
ID MILITARY PERSONNEL; SAFETY; SOLDIERS
AB Approximately 60-70% of Armed Forces personnel consume a dietary supplement (DS) at least once a week and there have been numerous reports of severe adverse events among DS users. This study assessed patterns of DS use and self-reported side-effects among 4400 Armed Forces personnel using a paper-and-pencil survey. Multivariable logistic regression was used to examine associations between patterns of DS use and self-reported side-effects. Sixty-nine percent of personnel surveyed reported using a DS. Seven percent of DS users reported experiencing abnormal heart beats, 6% tremors, 5% stomach pain, 3% dizziness, and 3% numbness/tingling and they believed these symptoms were associated with the use of DS. After adjustment for use of other DS classes, total supplement use, and demographic characteristics, protein supplement users were more likely than non-users to report numbness/tingling; combination product users were more likely to report experiencing abnormal heart beats, stomach pain, dizziness, tremors, and numbness/tingling; and users of purported steroid analogues were more likely to report dizziness. Use of more than one DS per week was associated with an increased likelihood of reporting side-effects. Respondents with a higher body mass index were more likely to report side-effects. Further research is necessary to determine whether self-reported side-effects associated with multiple DS use and some DS classes impact the long-term health or performance of service members. Surveillance of military populations using surveys like this one may provide a method for detecting adverse health events of DS before they are apparent in the civilian population. Copyright (c) 2015 John Wiley & Sons, Ltd.
C1 [Austin, Krista G.; Farina, Emily K.; Lieberman, Harris R.] US Army, Mil Nutr Div, Environm Med Res Inst, Kansas St,Bldg 42, Natick, MA 01760 USA.
[Austin, Krista G.; Farina, Emily K.] Oak Ridge Inst Sci & Educ, Belcamp, MD 21017 USA.
RP Lieberman, HR (reprint author), US Army, Mil Nutr Div, Environm Med Res Inst, Kansas St,Bldg 42, Natick, MA 01760 USA.
EM harris.r.lieberman.civ@mail.mil
FU US Army Medical Research and Materiel Command; Department of Defense
Center Alliance for Nutrition and Dietary Supplements Research
FX US Army Medical Research and Materiel Command; Department of Defense
Center Alliance for Nutrition and Dietary Supplements Research
NR 23
TC 1
Z9 1
U1 1
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1942-7603
EI 1942-7611
J9 DRUG TEST ANAL
JI Drug Test. Anal.
PD MAR-APR
PY 2016
VL 8
IS 3-4
SI SI
BP 287
EP 295
DI 10.1002/dta.1905
PG 9
WC Biochemical Research Methods; Chemistry, Analytical; Pharmacology &
Pharmacy
SC Biochemistry & Molecular Biology; Chemistry; Pharmacology & Pharmacy
GA DJ5NP
UT WOS:000374255900003
PM 26526399
ER
PT J
AU Snavely, TM
AF Snavely, Timothy M.
TI A Brief Economic Analysis of the Looming Nursing Shortage In the United
States
SO NURSING ECONOMICS
LA English
DT Article
AB The United States is projected to experience a nursing shortage in the coming years as market forces begin to shift away from equilibrium.
A return to pre-recession work levels, aging baby boomers, and insufficient numbers of nursing graduates adversely affect the supply of nurses
The aging population, a rise in chronic care management needs, and the Affordable Care Act will result in an increasing demand for them.
Returning to a state of equilibrium is critical if our health care system is to ensure care that is accessible, safe, and cost effective.
C1 [Snavely, Timothy M.] US Army, San Antonio, TX USA.
RP Snavely, TM (reprint author), US Army, San Antonio, TX USA.
NR 23
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Z9 0
U1 3
U2 4
PU JANNETTI PUBLICATIONS, INC
PI PITMAN
PA EAST HOLLY AVENUE, BOX 56, PITMAN, NJ 08071-0056 USA
SN 0746-1739
J9 NURS ECON
JI Nurs. Econ.
PD MAR-APR
PY 2016
VL 34
IS 2
BP 98
EP 100
PG 3
WC Nursing
SC Nursing
GA DJ5VE
UT WOS:000374277400009
PM 27265953
ER
PT J
AU Kaplan, D
Gong, Y
Mills, K
Swaminathan, V
Ajayan, PM
Shirodkar, S
Kaxiras, E
AF Kaplan, D.
Gong, Y.
Mills, K.
Swaminathan, V.
Ajayan, P. M.
Shirodkar, S.
Kaxiras, E.
TI Excitation intensity dependence of photoluminescence from monolayers of
MoS2 and WS2/MoS2 heterostructures
SO 2D MATERIALS
LA English
DT Article
DE Raman; molybdenum disulfide; CVD; excitation intensity dependence;
heterostructure; exciton; trion
ID TRANSITION-METAL DICHALCOGENIDES; MOLYBDENUM-DISULFIDE; LAYER MOS2;
TRIONS
AB A detailed study of the excitation dependence of the photoluminescence (PL) from monolayers of MoS2 and WS2/MoS2 heterostructures grown by chemical vapor deposition on Si substrates has revealed that the luminescence from band edge excitons from MoS2 monolayers shows a linear dependence on excitation intensity for both above band gap and resonant excitation conditions. In particular, a band separated by similar to 55 meV from the A exciton, referred to as the C band, shows the same linear dependence on excitation intensity as the band edge excitons. A band similar to the C band has been previously ascribed to a trion, a charged, three-particle exciton. However, in our study the C band does not show the 3/2 power dependence on excitation intensity as would be expected for a three-particle exciton. Further, the PL from the MoS2 monolayer in a bilayer WS2/MoS2 heterostructure, under resonant excitation conditions where only the MoS2 absorbs the laser energy, also revealed a linear dependence on excitation intensity for the C band, confirming that its origin is not due to a trion but instead a bound exciton, presumably of an unintentional impurity or a native point defect such as a sulfur vacancy. The PL from the WS2/MoS2 heterostructure, under resonant excitation conditions also showed additional features which are suggested to arise from the interface states at the heteroboundary. Further studies are required to clearly identify the origin of these features.
C1 [Kaplan, D.; Swaminathan, V.] US Army RDECOM ARDEC, Fuze Precis Armaments & Technol Directorate, Picatinny Arsenal, NJ 07806 USA.
[Gong, Y.; Ajayan, P. M.] Rice Univ, Dept Mat Sci & NanoEngn, Houston, TX 77005 USA.
[Mills, K.] US Army RDECOM ARDEC, Energet Warheads & Mfg Technol Directorate, Picatinny Arsenal, NJ 07806 USA.
[Shirodkar, S.; Kaxiras, E.] Harvard Univ, Dept Phys, Cambridge, MA 02138 USA.
[Shirodkar, S.; Kaxiras, E.] Harvard Univ, John A Paulson Sch Engn & Appl Sci, Cambridge, MA 02138 USA.
RP Kaplan, D (reprint author), US Army RDECOM ARDEC, Fuze Precis Armaments & Technol Directorate, Picatinny Arsenal, NJ 07806 USA.
EM daniel.b.kaplan.civ@mail.mil
FU Army Research office MURI [W911NF-11-1-0362, W911NF-14-1-0247]
FX YG and PMA would like to acknowledge support by the Army Research office
MURI grant W911NF-11-1-0362 and SS and EK would like to acknowledge
support by the Army Research office MURI grant W911NF-14-1-0247.
NR 27
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U1 29
U2 73
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 2053-1583
J9 2D MATER
JI 2D Mater.
PD MAR
PY 2016
VL 3
IS 1
AR 015005
DI 10.1088/2053-1583/3/1/015005
PG 10
WC Materials Science, Multidisciplinary
SC Materials Science
GA DJ1AU
UT WOS:000373936300025
ER
PT J
AU Harrell, LE
AF Harrell, L. E.
TI Wavefunction collapse through backaction of counting weakly interacting
photons
SO JOURNAL OF MATHEMATICAL PHYSICS
LA English
DT Article
ID VON-NEUMANN MEASUREMENT; QUANTUM; DECOHERENCE; MODELS
AB We apply the formalism of quantum measurement theory to the idealized measurement of the position of a particle with an optical interferometer, finding that the backaction of counting entangled photons systematically collapses the particle's wave-function toward a narrow Gaussian wavepacket at the location x(est) determined by the measurement without appeal to environmental decoherence or other spontaneous collapse mechanism. Further, the variance in the particle's position, as calculated from the post-measurement wavefunction, agrees precisely with shot-noise limited uncertainty of the measured x(est). Both the identification of the absolute square of the particle's initial wavefunction as the probability density for x(est) and the de Broglie hypothesis emerge as consequences of interpreting the intensity of the optical field as proportional to the probability of detecting a photon. Linear momentum information that is encoded in the particle's initial wavefunction survives the measurement, and the pre-measurement expectation values are preserved in the ensemble average. (C) 2016 AIP Publishing LLC.
C1 [Harrell, L. E.] US Mil Acad, Dept Phys & Nucl Engn, West Point, NY 10996 USA.
RP Harrell, LE (reprint author), US Mil Acad, Dept Phys & Nucl Engn, West Point, NY 10996 USA.
EM lee.harrell@usma.edu
FU Kavli Institute at Cornell for Nanoscale Science; National Science
Foundation [DMR-0634455]; IBM; Eastman Kodak; New York State Office of
Science, Technology, and Academic Research; Department of Physics and
Nuclear Engineering and the Mathematical Sciences Center of Excellence
of the U.S. Military Academy
FX I would like to thank John Sidles and Joseph Garbini of the University
of Washington for inspiring this work during visits to their labs during
July 2005 and June 2012 by teaching me how to develop the measurement
operators for the passage of a single photon through an optical
interferometer and encouraging me to explore the implications of
performing such a measurement iteratively. I would also like to thank
the organizers and participants of the international workshop, Magnetic
Resonance Force Microscopy: Routes to Three-Dimensional Imaging of
Single Molecules, held on June 21-24, 2006, at Cornell University, for
many helpful discussions. The workshop was supported by grants from the
Kavli Institute at Cornell for Nanoscale Science and the National
Science Foundation Under Grant No. DMR-0634455, with additional funding
from IBM, Eastman Kodak, and the New York State Office of Science,
Technology, and Academic Research. Additional support for this work was
provided by the Department of Physics and Nuclear Engineering and the
Mathematical Sciences Center of Excellence of the U.S. Military Academy.
The views expressed herein are those of the author and do not reflect
the position of the Department of the Army or the Department of Defense.
NR 40
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Z9 0
U1 0
U2 3
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0022-2488
EI 1089-7658
J9 J MATH PHYS
JI J. Math. Phys.
PD MAR
PY 2016
VL 57
IS 3
AR 032104
DI 10.1063/1.4944454
PG 10
WC Physics, Mathematical
SC Physics
GA DJ2DL
UT WOS:000374013800010
ER
PT J
AU Johnson, D
Giles, K
Acuna, A
Saenz, C
Bentley, M
Budinich, C
AF Johnson, Don
Giles, Kirk
Acuna, Alexis
Saenz, Crystal
Bentley, Michael
Budinich, Craig
TI Effects of tibial intraosseous and IV administration of vasopressin on
kinetics and survivability in cardiac arrest
SO AMERICAN JOURNAL OF EMERGENCY MEDICINE
LA English
DT Article
ID AMERICAN-HEART-ASSOCIATION; EMERGENCY CARDIOVASCULAR CARE;
CARDIOPULMONARY-RESUSCITATION; VENTRICULAR-FIBRILLATION; VENOUS ACCESS;
EPINEPHRINE; TRIAL; PHARMACOKINETICS; GUIDELINES; UPDATE
AB Purpose: Purposes of this study were to compare tibial intraosseous (TIO) and intravenous (IV) administration of vasopressin relative to return of spontaneous circulation (ROSC) and time to ROSC in an adult swine cardiac arrest model. In addition, the purposes were to compare the concentration maximum (Cmax), time to maximum concentration (Tmax), and odds of ROSC.
Methods: This was a between-subjects, prospective experimental study. Yorkshire swine (N=21) were randomly assigned to 1 of 3 groups: TIO, IV, or control groups. The swine were anesthetized and instrumented, and then cardiac arrest was induced and sustained for 2 minutes. Cardiopulmonary resuscitation was initiated and continued for 2 minutes. Vasopressin was then administered via the TIO or IV route. Blood samples were collected for 4 minutes to determine the Cmax and Tmax of vasopressin. Concentration maximum and Tmax were calculated by use of liquid chromatography with mass spectrometry.
Results: There was no difference in ROSC between the TIO and IV groups (P=.63). The Cmax of vasopressin was significantly higher in the IV group compared to the TIO group (P=.017). However, there was no significant difference in ROSC, time to ROSC, or Tmax between groups (P>.05). All subjects had ROSC in both the IV and TIO groups, and none had ROSC in the control group. There was 225 times greater chance of survival for both the IV and TIO groups compared to the control group.
Conclusion: The data support that the TIO is an effective route for vasopressin in a cardiac arrest model. Published by Elsevier Inc.
C1 [Johnson, Don; Giles, Kirk; Acuna, Alexis; Saenz, Crystal; Bentley, Michael; Budinich, Craig] Acad Hlth Sci, Dept Army, Ft Sam Houston, TX 78234 USA.
[Giles, Kirk; Acuna, Alexis; Saenz, Crystal] US Army, Grad Program Anesthesia Nursing, Washington, DC USA.
RP Johnson, D (reprint author), Acad Hlth Sci, Dept Army, Ft Sam Houston, TX 78234 USA.
EM arthurjohnso@gmail.com; Giles.k@husky.neu.edu; acuna.a@husky.neu.edu;
saenz.c@husky.neu.edu; armygas@gmail.com; craig.budinich@gmail.com
FU TriService Nursing Research Program [N13-P10]
FX This study was funded with a study from TriService Nursing Research
Program grant number (N13-P10).
NR 30
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U1 1
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PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0735-6757
EI 1532-8171
J9 AM J EMERG MED
JI Am. J. Emerg. Med.
PD MAR
PY 2016
VL 34
IS 3
BP 429
EP 432
DI 10.1016/j.ajem.2015.11.027
PG 4
WC Emergency Medicine
SC Emergency Medicine
GA DI4TB
UT WOS:000373491100014
PM 26778642
ER
PT J
AU Gardony, AL
Taylor, HA
Brunye, TT
AF Gardony, Aaron L.
Taylor, Holly A.
Brunye, Tad T.
TI Gardony Map Drawing Analyzer: Software for quantitative analysis of
sketch maps
SO BEHAVIOR RESEARCH METHODS
LA English
DT Article
DE Sketch maps; Cognitive mapping; Spatial memory; Mental models
ID VISUAL WORKING-MEMORY; BIDIMENSIONAL REGRESSION; ENVIRONMENTS;
PERFORMANCE; ABILITIES; LOCATION
AB Sketch maps are effective tools for assessing spatial memory. However, despite their widespread use in cognitive science research, sketch map analysis techniques remain unstandardized and carry limitations. In the present article, we present the Gardony Map Drawing Analyzer (GMDA), an open-source software package for sketch map analysis. GMDA combines novel and established analysis techniques into a graphical user interface that permits rapid computational sketch map analysis. GMDA calculates GMDA-unique measures based on pairwise comparisons between landmarks, as well as bidimensional regression parameters (Friedman & Kohler, 2003), which together reflect sketch map quality at two levels: configural and individual landmark. The configural measures assess the overall landmark configuration and provide a whole-map analysis. Individual landmark measures, introduced in GMDA, assess individual landmark placement and indicate how individual landmarks contribute to the configural scores. Together, these measures provide a more complete psychometric picture of sketch map analysis, allowing for comparisons between sketch maps and between landmarks. The calculated measures reflect specific and cognitively relevant aspects of interlandmark spatial relationships, including distance and angular representation. GMDA supports complex environments (up to 48 landmarks) and two software modes that capture aspects of maps not addressed by existing techniques, such as landmark size and shape variation and interlandmark containment relationships. We describe the software and its operation and present a formal specification of calculation procedures for its unique measures. We then validate the software by demonstrating the capabilities and reliability of its measures using simulation and experimental data. The most recent version of GMDA is available at www.aarongardony.com/tools/map-drawing-analyzer.
C1 [Gardony, Aaron L.; Brunye, Tad T.] US Army, Natick Soldier Res Dev & Engn Ctr, Cognit Sci Team, Natick, MA 01760 USA.
[Gardony, Aaron L.; Taylor, Holly A.; Brunye, Tad T.] Tufts Univ, Dept Psychol, 490 Boston Ave, Medford, MA 02155 USA.
RP Gardony, AL (reprint author), Tufts Univ, Dept Psychol, 490 Boston Ave, Medford, MA 02155 USA.
EM agardony@gmail.com
NR 36
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U1 1
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1554-351X
EI 1554-3528
J9 BEHAV RES METHODS
JI Behav. Res. Methods
PD MAR
PY 2016
VL 48
IS 1
BP 151
EP 177
DI 10.3758/s13428-014-0556-x
PG 27
WC Psychology, Mathematical; Psychology, Experimental
SC Psychology
GA DI6DC
UT WOS:000373588400012
PM 25673320
ER
PT J
AU Seay, JF
Sauer, SG
Patel, T
Roy, TC
AF Seay, Joseph F.
Sauer, Shane G.
Patel, Tejash
Roy, Tanja C.
TI A history of low back pain affects pelvis and trunk coordination during
a sustained manual materials handling task
SO JOURNAL OF SPORT AND HEALTH SCIENCE
LA English
DT Article
DE Lifting; Lowering; Occupational biomechanics; Relative phase; Relative
phase variability
ID DYNAMICAL-SYSTEMS APPROACH; RISK-FACTORS; WALKING; INJURY; VARIABILITY;
WORKERS
AB Purpose: The purpose of this study was to compare the coordination between the trunk and the pelvis during a sustained asymmetric repetitive lifting task between a group with a history of low back pain (LBP; HBP) and a group with no history of LBP (NBP).
Methods: Volunteers lifted a 11-kg box from ankle height in front to a shelf 45 degrees off-center at waist height, and lowered it to the start position at 12 cycles/min for 10 min. Lifting side was alternated during the trial. Continuous relative phase was used to calculate coordination between the pelvis and trunk rotation at the beginning (Min 1), middle (Min 5), and end of the bout (Min 9).
Results: While there were no main effects for group, a significant interaction between time and group indicated that, in the frontal plane, the NBP group coordination was more anti-phase toward the end of the bout, with no such differences for the HBP group. Analysis of sagittal-axial (bend and twist) coordination revealed the HBP group coordination was more in-phase at the end of the bout over the entire cycle and for the lifting phase alone, with no such differences for the NBP group.
Conclusion: Differences between groups demonstrate residual consequences of LBP in an occupational scenario, even though the HBP group was pain-free for >6 months prior to data collection. More in-phase coordination in the HBP group may represent a coordination pattern analogous to "guarded gait" which has been observed in other studies, and may lend insight as to why these individuals are at increased risk for re-injury. (C) 2016 Production and hosting by Elsevier B.V. on behalf of Shanghai University of Sport.
C1 [Seay, Joseph F.; Sauer, Shane G.; Roy, Tanja C.] US Army, Mil Performance Div, Environm Med Res Inst, Natick, MA 01760 USA.
[Patel, Tejash] US Army, Biophys & Biomed Modelling Div, Environm Med Res Inst, Natick, MA 01760 USA.
RP Seay, JF (reprint author), US Army, Mil Performance Div, Environm Med Res Inst, Natick, MA 01760 USA.
EM joseph.f.seay.civ@mail.mil
NR 36
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U1 4
U2 4
PU SHANGHAI UNIV SPORT
PI SHANGHAI
PA EDITORIAL BOARD, 650 QINGYUANHUAN RD, SHANGHAI, 200438, PEOPLES R CHINA
SN 2095-2546
EI 2213-2961
J9 J SPORT HEALTH SCI
JI J. Sport Health Sci.
PD MAR
PY 2016
VL 5
IS 1
BP 52
EP 60
DI 10.1016/j.jshs.2016.01.011
PG 9
WC Hospitality, Leisure, Sport & Tourism; Sport Sciences
SC Social Sciences - Other Topics; Sport Sciences
GA DI8AH
UT WOS:000373722600007
ER
PT J
AU Ferguson, JB
Lopez, HF
Cho, K
Kim, CS
AF Ferguson, J. B.
Lopez, Hugo F.
Cho, Kyu
Kim, Chang-Soo
TI Temperature Effects on the Tensile Properties of Precipitation-Hardened
Al-Mg-Cu-Si Alloys
SO METALS
LA English
DT Article
DE tensile properties; temperature effects; Al alloys;
precipitation-hardened alloys; property modeling
ID CASTING ALLOYS; HEAT-TREATMENT; ALUMINUM; MODEL; MICROSTRUCTURE;
DEFORMATION; EVOLUTION; BEHAVIOR; STORAGE
AB Because the mechanical performance of precipitation-hardened alloys can be significantly altered with temperature changes, understanding and predicting the effects of temperatures on various mechanical properties for these alloys are important. In the present work, an analytical model has been developed to predict the elastic modulus, the yield stress, the failure stress, and the failure strain taking into consideration the effect of temperatures for precipitation-hardenable Al-Mg-Cu-Si Alloys (Al-A319 alloys). In addition, other important mechanical properties of Al-A319 alloys including the strain hardening exponent, the strength coefficient, and the ductility parameter can be estimated using the current model. It is demonstrated that the prediction results based on the proposed model are in good agreement with those obtained experimentally in Al-A319 alloys in the as-cast condition and after W and T7 heat treatments.
C1 [Ferguson, J. B.; Lopez, Hugo F.; Kim, Chang-Soo] Univ Wisconsin, Dept Mat Sci & Engn, Milwaukee, WI 53211 USA.
[Cho, Kyu] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
RP Kim, CS (reprint author), Univ Wisconsin, Dept Mat Sci & Engn, Milwaukee, WI 53211 USA.
EM jbf2@uwm.edu; hlopez@uwm.edu; kyu.c.cho2.civ@mail.mil; kimcs@uwm.edu
FU U.S. Army Research laboratory [W911NF-15-2-0005]
FX This materials is based upon work supported by the U.S. Army Research
laboratory under Cooperative Agreement No. W911NF-15-2-0005. The views,
opinions, and conclusions made in this document are those of authors and
should not be interpreted the official policies, either expressed or
implied, of Army Research Laboratory or the U.S. Government. The U.S.
Government is authorized to reproduce and distribute reprints for
Government purposes notwithstanding any copyright notation herein.
NR 16
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Z9 1
U1 8
U2 15
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 2075-4701
J9 METALS-BASEL
JI Metals
PD MAR
PY 2016
VL 6
IS 3
DI 10.3390/met6030043
PG 12
WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical
Engineering
SC Materials Science; Metallurgy & Metallurgical Engineering
GA DI6NR
UT WOS:000373616800026
ER
PT J
AU Stoddard, DR
Sebesta, JA
Welder, MD
Foster, AJ
Rush, RM
AF Stoddard, Douglas R.
Sebesta, James A.
Welder, Matthew D.
Foster, Andrew J.
Rush, Robert M.
TI What Patients Really Want: Optimizing the Military Preoperative
Evaluation Clinic
SO MILITARY MEDICINE
LA English
DT Article
ID WAITING-TIMES
AB The idea of the preoperative anesthesia clinic as a means of examining and treating the patient so that he will arrive in the operating theater as strong and healthy as possible is well established in practice and literature. However, problems in clinic design and execution often result in high patient waiting times, decreased patient and staff satisfaction, decreased patient capacity, and high clinic costs. Although the details of clinic design, outcomes, and satisfaction have been extensively evaluated at civilian hospitals, we have not found corresponding literature addressing these issues specifically within military preoperative evaluation clinics. We find that changing to an appointment-based (versus walk-in) system and eliminating data collection step redundancies will likely result in lower wait times, higher satisfaction, lower per patient costs, and a more streamlined and resource-efficient structure.
C1 [Stoddard, Douglas R.; Sebesta, James A.; Foster, Andrew J.; Rush, Robert M.] Madigan Army Med Ctr, 9040 Jackson Ave, Tacoma, WA 98431 USA.
[Welder, Matthew D.] US Army Med Command, Off Surg Gen, 7700 Arlington Blvd, Falls Church, VA 22032 USA.
RP Stoddard, DR (reprint author), Madigan Army Med Ctr, 9040 Jackson Ave, Tacoma, WA 98431 USA.
NR 15
TC 1
Z9 1
U1 1
U2 4
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAR
PY 2016
VL 181
IS 3
BP 236
EP 242
DI 10.7205/MILMED-D-15-00072
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA DI3NJ
UT WOS:000373405100018
PM 26926748
ER
PT J
AU Sell, TC
Abt, JP
Nagai, T
Deluzio, JB
Lovalekar, M
Wirt, MD
Lephart, SM
AF Sell, Timothy C.
Abt, John P.
Nagai, Takashi
Deluzio, Jennifer B.
Lovalekar, Mita
Wirt, Michael D.
Lephart, Scott M.
TI The Eagle Tactical Athlete Program Reduces Musculoskeletal Injuries in
the 101st Airborne Division (Air Assault)
SO MILITARY MEDICINE
LA English
DT Article
ID FITNESS OUTCOMES; MILITARY; ARMY; SURVEILLANCE; PERFORMANCE; SOLDIERS;
SPORTS; HEALTH
AB The Eagle Tactical Athlete Program (ETAP) was scientifically developed for the U.S. Army's 101st Airborne Division (Air Assault) to counter unintentional musculoskeletal injuries (MSIs). Purpose: To determine if ETAP would reduce unintentional MSIs in a group of 101st Airborne Division (Air Assault) Soldiers. Methods: ETAP-trained noncommissioned led physical training. 1,720 Soldiers were enrolled (N = 1,136 experimental group [EXP], N = 584 control group [CON]) with injuries tracked before and after initiation of ETAP. The International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes were analyzed and described the anatomic locations, anatomic sub-locations, onset, and injury types. McNemar tests compared the proportions of injured subjects within each group. Results: There was a significant reduction in the proportion of Soldiers with preventable MSIs in the EXP (pre: 213/1,136 (18.8%), post: 180/1,136 (15.8%), p = 0.041) but not in the CON. In addition, there was a significant reduction in stress fractures in the EXP (pre: 14/1,136 (1.2%), post: 5/1,136 (0.4%), p = 0.022) but no significant differences in the CON. Conclusion: The current analysis demonstrated that ETAP reduces preventable MSIs in garrison. The capability of ETAP to reduce injuries confirms the vital role of a scientifically designed training program on force readiness and health.
C1 [Sell, Timothy C.; Abt, John P.; Nagai, Takashi; Deluzio, Jennifer B.; Lovalekar, Mita; Lephart, Scott M.] Univ Pittsburgh, Neuromuscular Res Lab, 3830 South Water St, Pittsburgh, PA 15203 USA.
[Wirt, Michael D.] US Army, Inst Surg Res, 3698 Chambers Pass Bldg,3611 JBSA, Ft Sam Houston, TX 78234 USA.
RP Sell, TC (reprint author), Univ Pittsburgh, Neuromuscular Res Lab, 3830 South Water St, Pittsburgh, PA 15203 USA.
FU U.S. Army Medical Research and Materiel Command
[W81XWH-06-2-0070/W81XWH-09-2-0095/W81XWH-11-2-0097]
FX We would like to thank the Soldiers of the U.S Army's 101st Airborne
Division (Air Assault). Their time and effort was essential to the
success of the ETAP. Supported by the U.S. Army Medical Research and
Materiel Command under Award No.
W81XWH-06-2-0070/W81XWH-09-2-0095/W81XWH-11-2-0097.
NR 23
TC 0
Z9 0
U1 6
U2 8
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAR
PY 2016
VL 181
IS 3
BP 250
EP 257
DI 10.7205/MILMED-D-14-00674
PG 8
WC Medicine, General & Internal
SC General & Internal Medicine
GA DI3NJ
UT WOS:000373405100020
PM 26926750
ER
PT J
AU Sharkey, JM
Abraham, JH
Clark, LL
Rohrbeck, P
Ludwig, SL
Hu, Z
Baird, CP
AF Sharkey, Jessica M.
Abraham, Joseph H.
Clark, Leslie L.
Rohrbeck, Patricia
Ludwig, Sharon L.
Hu, Zheng
Baird, Coleen P.
TI Postdeployment Respiratory Health Care Encounters Following Deployment
to Kabul, Afghanistan: A Retrospective Cohort Study
SO MILITARY MEDICINE
LA English
DT Article
ID US MILITARY PERSONNEL; MEDICAL ENCOUNTERS; PARTICULATE MATTER; SOUTHWEST
ASIA; SYMPTOMS; IRAQ; PREVALENCE; EXPOSURE; SOLDIERS; WARRIOR
AB Inhalational hazards are numerous in operational environments. A retrospective cohort study was conducted to investigate associations between deployment to Kabul, Afghanistan and subsequent respiratory health among U.S. military personnel. The study population consisted of personnel who deployed to Kabul, select Operation Enduring Freedom locations, personnel stationed in the Republic of Korea, and U.S.-stationed personnel. Incidence rate ratios (IRRs) were estimated for respiratory symptoms, signs, and ill-defined conditions, asthma, and chronic obstructive pulmonary disease. A significantly elevated rate of symptoms, signs, and ill-defined conditions was observed among Kabul-deployed personnel compared to personnel deployed or stationed in Bagram (IRR 1.12; 95% confidence interval [CI], 1.05-1.19), Republic of Korea (IRR 1.20; 95% CI, 1.10-1.31), and the United States (IRR 1.52; 95% CI, 1.43-1.62). A statistically elevated rate of asthma was observed among personnel deployed to Kabul, relative to U.S.-stationed personnel (IRR 1.61; 95% CI, 1.22-2.12). Statistically significant rates were not observed for chronic obstructive pulmonary disease among Kabul-deployed personnel compared to other study groups. These findings suggest that deployment to Kabul is associated with an elevated risk of postdeployment respiratory symptoms and new-onset asthma.
C1 [Sharkey, Jessica M.; Abraham, Joseph H.; Baird, Coleen P.] US Army, Publ Hlth Command, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA.
[Clark, Leslie L.; Rohrbeck, Patricia; Ludwig, Sharon L.; Hu, Zheng] Armed Forces Hlth Surveillance Ctr, 11800 Tech Rd, Silver Spring, MD 20910 USA.
RP Sharkey, JM (reprint author), US Army, Publ Hlth Command, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA.
NR 27
TC 2
Z9 2
U1 0
U2 1
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAR
PY 2016
VL 181
IS 3
BP 265
EP 271
DI 10.7205/MILMED-D-14-00690
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA DI3NJ
UT WOS:000373405100022
PM 26926752
ER
PT J
AU Mitchell, TA
Lauer, CL
Aden, JK
Edwards, KD
Bailey, JA
White, CE
Blackbourne, LH
Holcomb, JB
AF Mitchell, Thomas A.
Lauer, Cynthia L.
Aden, James K.
Edwards, Kurt D.
Bailey, Jeffrey A.
White, Christopher E.
Blackbourne, Lorne H.
Holcomb, John B.
TI Short-Term Outcomes and Complications of Damage Control and Definitive
Laparotomy in Deployed Combat Environments: 2002 to 2011
SO MILITARY MEDICINE
LA English
DT Article
ID CONTROL SURGERY; MANAGEMENT; BATTLEFIELD; CASUALTIES; SURVIVAL; INJURY;
TRAUMA; TIME
AB Introduction: Damage control laparotomy (DCL) in an austere environment is an evolving surgical modality.
Methods: A retrospective evaluation of all patients surviving 24 hours who underwent a laparotomy from 2002 to 2011 in Iraq and Afghanistan was performed. DCL was defined as a patient undergoing laparotomy at two distinct North American Treaty Organization (NATO) Role 2 or 3 medical treatment facilities (MTFs); a NATO Roles 2 and 3 MTFs, and/or having the International Classification of Diseases, 9th Revision, Clinical Modification procedure code 54.12, for reopening of recent laparotomy site. Definitive laparotomy (DL) was defined as patients undergoing one operative procedure at one NATO Role 2 or 3 MTF. Demographic data including injury severity scores, hematological transfusion, mortality, intraperitoneal or retroperitoneal operative interventions, and complications were compared.
Results: DCL composed of 26.5% (n = 331) of all 1,248 laparotomies performed between March 2002 and September 2011. Total intra-abdominal, acute respiratory distress syndrome, and thromboembolic complications for DCL versus DL were 8.5% and 5.6% (p = 0.07), 2.1% and 0.8% (p = 0.06), and 1.5% and 0.7% (p = 0.17), respectively. Theater discharge mortality from DCL and DL were 1.5% (n = 5), and 1.4% (n = 13) (p = 0.90), respectively.
Conclusions: In conclusion, excluding deaths with the first 24 hours, DCL and DL had comparable mortality and complication rates at NATO Roles 2 and 3 MTFs.
C1 [Mitchell, Thomas A.; Lauer, Cynthia L.; Edwards, Kurt D.; White, Christopher E.; Blackbourne, Lorne H.] San Antonio Mil Med Ctr, Dept Gen Surg, 3551 Roger Brooke Dr, Jbsa Ft Sam Houston, TX 78234 USA.
[Aden, James K.; Bailey, Jeffrey A.] US Army, Inst Surg Res, 3698 Chambers Pass STE B, Jbsa Ft Sam Houston, TX 78234 USA.
[Holcomb, John B.] Univ Texas Hlth Sci Ctr Houston, Div Acute Care Surg, Dept Surg, 7000 Fannin St, Houston, TX 77030 USA.
RP Mitchell, TA (reprint author), San Antonio Mil Med Ctr, Dept Gen Surg, 3551 Roger Brooke Dr, Jbsa Ft Sam Houston, TX 78234 USA.
FU U.S. Military
FX The authors acknowledge the Department of Defense Trauma Registry
(DoDTR) and the Patient Administration Systems and Biostatistics
Activity (PASBA) for providing data for this study. The authors would
like to disclose that no external funds were used to finance this
project, and the U.S. Military was solely responsible for funding this
research.
NR 15
TC 0
Z9 0
U1 0
U2 4
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAR
PY 2016
VL 181
IS 3
BP 277
EP 282
DI 10.7205/MILMED-D-14-00726
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA DI3NJ
UT WOS:000373405100024
PM 26926754
ER
PT J
AU Stacey, SK
Novek, SJ
Maddox, CL
AF Stacey, Stephen K.
Novek, Steven J.
Maddox, Craig L.
TI Pityriasis Rubra Pilaris in a 3-Year-Old Male
SO MILITARY MEDICINE
LA English
DT Article
AB A 3-year-old male presented with progressive pruritic red-orange plaques across most of his body with erythema, desquamation, and fissuring of the hands and feet. He was diagnosed with classic juvenile (type III) pityriasis rubra pilaris (PRP) and treated with oral isotretinoin for 6 months. His skin findings resolved quickly during the treatment period, with residual postinflammatory hypopigmentation resolving within a year. PRP is rare in pediatric patients and standard recommended treatment algorithms for this population are not currently available. Diagnostic and treatment guidelines for PRP are based almost exclusively on case reports or case series, most of which focus on adult patients. The presentation, evaluation, and management of PRP are discussed.
C1 [Stacey, Stephen K.] 1-503 IN ABN,173D IBCT A,CMR 427 Box 2962, APO, AE 09630 USA.
[Novek, Steven J.] US Army, Hlth Ctr Vicenza, CMR 427, APO, AE 09630 USA.
[Maddox, Craig L.] US Army, Hlth Ctr Vicenza, Dept Clin Specialties & Dermatol Serv, CMR 427, APO, AE 09630 USA.
RP Stacey, SK (reprint author), 1-503 IN ABN,173D IBCT A,CMR 427 Box 2962, APO, AE 09630 USA.
NR 10
TC 0
Z9 0
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAR
PY 2016
VL 181
IS 3
BP E298
EP E301
DI 10.7205/MILMED-D-15-00316
PG 4
WC Medicine, General & Internal
SC General & Internal Medicine
GA DI3NJ
UT WOS:000373405100002
PM 26926758
ER
PT J
AU Granz, CD
Schindler, BJ
Peterson, GW
Whitten, JE
AF Granz, Christopher D.
Schindler, Bryan J.
Peterson, Gregory W.
Whitten, James E.
TI A fiber optic, ultraviolet light-emitting diode-based, two wavelength
fluorometer for monitoring reactive adsorption
SO REVIEW OF SCIENTIFIC INSTRUMENTS
LA English
DT Article
ID PHOTOLUMINESCENCE PROPERTIES; ZIRCONIUM HYDROXIDE; SURFACE-CHEMISTRY;
SULFUR-DIOXIDE; REMOVAL; THIOL; FILMS
AB Construction and use of an ultraviolet light-emitting diode-based fluorometer for measuring photoluminescence (PL) from powder samples with a fiber optic probe is described. Fluorescence at two wavelengths is detected by miniature photomultiplier tubes, each equipped with a different band pass filter, whose outputs are analyzed by a microprocessor. Photoluminescent metal oxides and hydroxides, and other semiconducting nanoparticles, often undergo changes in their emission spectra upon exposure to reactive gases, and the ratio of the PL intensities at two wavelengths is diagnostic of adsorption. Use of this instrument for reactive gas sensing and gas filtration applications is illustrated by measuring changes in the PL ratio for zirconium hydroxide and zinc oxide particles upon exposure to air containing low concentrations of sulfur dioxide. (C) 2016 AIP Publishing LLC.
C1 [Granz, Christopher D.; Whitten, James E.] Univ Massachusetts, Dept Chem, Lowell, MA 01854 USA.
[Schindler, Bryan J.] Leidos Inc, POB 68, Gunpowder, MD 21010 USA.
[Peterson, Gregory W.] US Army Edgewood Chem & Biol Ctr, Aberdeen Proving Ground, MD 21010 USA.
RP Whitten, JE (reprint author), Univ Massachusetts, Dept Chem, Lowell, MA 01854 USA.
EM James_Whitten@uml.edu
FU Army Research Office; Defense Threat Reduction Agency [BA07PRO105]
FX The authors acknowledge support from the Army Research Office. This work
was conducted under Defense Threat Reduction Agency, Project No.
BA07PRO105.
NR 22
TC 0
Z9 0
U1 5
U2 9
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0034-6748
EI 1089-7623
J9 REV SCI INSTRUM
JI Rev. Sci. Instrum.
PD MAR
PY 2016
VL 87
IS 3
AR 035121
DI 10.1063/1.4944761
PG 7
WC Instruments & Instrumentation; Physics, Applied
SC Instruments & Instrumentation; Physics
GA DI7WS
UT WOS:000373713300083
PM 27036833
ER
PT J
AU Baimukanova, G
Miyazawa, B
Potter, DR
Muench, MO
Bruhn, R
Gibb, SL
Spinella, PC
Cap, AP
Cohen, MJ
Pati, S
AF Baimukanova, Gyulnar
Miyazawa, Byron
Potter, Daniel R.
Muench, Marcus O.
Bruhn, Roberta
Gibb, Stuart L.
Spinella, Philip C.
Cap, Andrew P.
Cohen, Mitchell J.
Pati, Shibani
TI Platelets regulate vascular endothelial stability: assessing the storage
lesion and donor variability of apheresis platelets
SO TRANSFUSION
LA English
DT Article
ID TRAUMATIC BRAIN-INJURY; FRESH-FROZEN PLASMA; LARGE ANIMAL-MODEL; 22
DEGREES C; HEMORRHAGIC-SHOCK; MOLECULAR-BASIS; RESUSCITATION;
PERMEABILITY; TRANSFUSION; MAINTENANCE
AB BACKGROUNDIn current blood banking practices, platelets (PLTs) are stored in plasma at 22 degrees C, with gentle agitation for up to 5 days. To date, the effects of storage and donor variability on PLT regulation of vascular integrity are not known.
STUDY DESIGN AND METHODSIn this study, we examined the donor variability of leukoreduced fresh (Day 1) or stored (Day 5) PLTs on vascular endothelial barrier function in vitro and in vivo. In vitro, PLT effects on endothelial cell (EC) monolayer permeability were assessed by analyzing transendothelial electrical resistances (TEER). PLT aggregation, a measure of hemostatic potential, was analyzed by impedance aggregometry. In vivo, PLTs were investigated in a vascular endothelial growth factor A (VEGF-A)-induced vascular permeability model in NSG mice, and PLT circulation was measured by flow cytometry.
RESULTSTreatment of endothelial monolayers with fresh Day 1 PLTs resulted in an increase in EC barrier resistance and decreased permeability in a dose-dependent manner. Subsequent treatment of EC monolayers with Day 5 PLTs demonstrated diminished vasculoprotective effects. Donor variability was noted in all measures of PLT function. Day 1 PLT donors were more variable in their effects on TEER than Day 5 PLTs. In mice, while all PLTs regardless of storage time demonstrated significant protection against VEGF-A-induced vascular leakage, Day 5 PLTs exhibited reduced protection when compared to Day 1 PLTs. Day 1 PLTs demonstrated significant donor variability against VEGF-A-challenged vascular leakage in vivo. Systemic circulating levels of Day 1 PLTs were higher than those of Day 5 PLTs
CONCLUSIONSIn vitro and in vivo, Day 1 PLTs are protective in measures of vascular endothelial permeability. Donor variability is most prominent in Day 1 PLTs. A decrease in the protective effects is found with storage of the PLT units between Day 1 and Day 5 at 22 degrees C, thereby suggesting that Day 5 PLTs are diminished in their ability to attenuate vascular endothelial permeability.
C1 [Baimukanova, Gyulnar; Potter, Daniel R.; Muench, Marcus O.; Bruhn, Roberta; Gibb, Stuart L.; Pati, Shibani] Blood Syst Res Inst, 270 Mason Ave, San Francisco, CA 94118 USA.
[Miyazawa, Byron; Cohen, Mitchell J.] Univ Calif San Francisco, Dept Surg, San Francisco, CA USA.
[Pati, Shibani] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA.
[Spinella, Philip C.] Washington Univ, Sch Med, Dept Pediat, Div Crit Care Med, St Louis, MO 63110 USA.
[Cap, Andrew P.] US Army, Inst Surg Res USAISR, Jbsa Ft Sam Houston, TX USA.
RP Pati, S (reprint author), Blood Syst Res Inst, 270 Mason Ave, San Francisco, CA 94118 USA.
EM spati@bloodsystems.org
RI Muench, Marcus/C-5025-2009
OI Muench, Marcus/0000-0001-8946-6605
FU National Institutes of Health [P01 DK088760]; Blood Systems Research
Institute
FX This work was supported by grants from the National Institutes of
Health, P01 DK088760 (to MM), and funding from Blood Systems Research
Institute.
NR 39
TC 2
Z9 2
U1 0
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0041-1132
EI 1537-2995
J9 TRANSFUSION
JI Transfusion
PD MAR
PY 2016
VL 56
SU 1
SI SI
BP S65
EP S75
DI 10.1111/trf.13532
PG 11
WC Hematology
SC Hematology
GA DI2YJ
UT WOS:000373364800009
PM 27001364
ER
PT J
AU Baimukanova, G
Miyazawa, B
Potter, DR
Gibb, SL
Keating, S
Danesh, A
Beyer, A
Dayter, Y
Bruhn, R
Muench, MO
Cap, AP
Norris, PJ
Spinella, P
Cohen, M
Pati, S
AF Baimukanova, Gyulnar
Miyazawa, Byron
Potter, Daniel R.
Gibb, Stuart L.
Keating, Sheila
Danesh, Ali
Beyer, Ashley
Dayter, Yelena
Bruhn, Roberta
Muench, Marcus O.
Cap, Andrew P.
Norris, Philip J.
Spinella, Philip
Cohen, Mitchell
Pati, Shibani
TI The effects of 22 degrees C and 4 degrees C storage of platelets on
vascular endothelial integrity and function
SO TRANSFUSION
LA English
DT Article
ID FRESH-FROZEN PLASMA; HEMORRHAGIC-SHOCK; P-SELECTIN; TEMPERATURE STORAGE;
MOLECULAR-BASIS; TRAUMA PATIENTS; DEGREES-C; IN-VIVO; BLOOD; TRANSFUSION
AB BACKGROUNDAlthough a majority of the studies conducted to date on platelet (PLT) storage have been focused on PLT hemostatic function, the effects of 4 degrees C PLTs on regulation of endothelial barrier permeability are still not known. In this study, we compared the effects of room temperature (22 degrees C) stored and (4 degrees C) stored PLTs on the regulation of vascular endothelial cell (EC) permeability in vitro and in vivo.
STUDY DESIGN AND METHODSDay 1, Day 5, and Day 7 leukoreduced apheresis PLTs stored at 4 or 22 degrees C were studied in vitro and in vivo. In vitro, PLT effects on EC permeability and barrier function, adhesion, and impedance aggregometry were investigated. In vivo, using a mouse model of vascular leak, attenuation of vascular leak and circulating PLT numbers were measured.
RESULTSTreatment of EC monolayers with Day 5 or Day 7 PLTs, stored at both 22 degrees C and 4 degrees C, resulted in similar decreases in EC permeability on average. However, analysis of individual samples revealed significant variation that was donor dependent. Additional in vitro measurements revealed a decrease in inflammatory mediators, nonspecific PLT-endothelial aggregation and attenuated loss of aggregation over time to TRAP, ASPI, ADP, and collagen with 4 degrees C storage. In mice, while 22 degrees C and 4 degrees C PLTs both demonstrated significant protection against vascular endothelial growth factor A (VEGF-A)-induced vascular leak 22 degrees C PLTs exhibited increased protection compared to 4 degrees C PLTs. Systemic circulating levels of 4 degrees C PLTs were decreased compared to 22 degrees C PLTs.
CONCLUSIONSIn vitro, 4 degrees C-stored PLTs exhibit a greater capacity to inhibit EC permeability than 22 degrees C-stored PLTs. In vivo, 22 degrees C PLTs provide superior control of vascular leak induced by VEGF-A. This discrepancy may be due to increased clearance of 4 degrees C PLTs from the systemic circulation.
C1 [Baimukanova, Gyulnar; Potter, Daniel R.; Gibb, Stuart L.; Keating, Sheila; Danesh, Ali; Beyer, Ashley; Dayter, Yelena; Bruhn, Roberta; Muench, Marcus O.; Norris, Philip J.; Pati, Shibani] Univ Calif San Francisco, Blood Syst Res Inst, San Francisco, CA 94143 USA.
[Miyazawa, Byron; Cohen, Mitchell] Univ Calif San Francisco, Dept Surg, San Francisco, CA 94143 USA.
[Cap, Andrew P.] US Army Inst Surg Res, Coagulat & Blood Res Program, Jbsa Ft Sam Houston, TX USA.
[Danesh, Ali; Norris, Philip J.; Pati, Shibani] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA.
[Spinella, Philip] Washington Univ, Dept Pediat, St Louis, MO 63130 USA.
RP Pati, S (reprint author), Blood Syst Res Inst, 270 Masonic Ave, San Francisco, CA 94118 USA.
EM spati@bloodsystems.org
RI Muench, Marcus/C-5025-2009
OI Muench, Marcus/0000-0001-8946-6605
NR 65
TC 1
Z9 1
U1 0
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0041-1132
EI 1537-2995
J9 TRANSFUSION
JI Transfusion
PD MAR
PY 2016
VL 56
SU 1
SI SI
BP S52
EP S64
DI 10.1111/trf.13455
PG 13
WC Hematology
SC Hematology
GA DI2YJ
UT WOS:000373364800008
PM 27001362
ER
PT J
AU Bynum, JA
Meledeo, MA
Getz, TM
Rodriguez, AC
Aden, JK
Cap, AP
Pidcoke, HF
AF Bynum, James A.
Meledeo, M. Adam
Getz, Todd M.
Rodriguez, Armando C.
Aden, James K.
Cap, Andrew P.
Pidcoke, Heather F.
TI Bioenergetic profiling of platelet mitochondria during storage: 4
degrees C storage extends platelet mitochondrial function and viability
SO TRANSFUSION
LA English
DT Article
ID CHILLED BLOOD-PLATELETS; HEMOSTATIC EFFECTIVENESS; VIABLE PLATELETS;
COLD-STORAGE; WHOLE-BLOOD; AGGREGATION; TRANSFUSION; OXYGEN;
RESPIRATION; REACTIVITY
AB BACKGROUNDPlatelets (PLTs) are stored at room temperature (RT) to preserve in vivo circulation time, but PLT quality is degraded. The PLT storage lesion is mitigated by refrigeration, but questions remain regarding effects of cold storage (4 degrees C) on mitochondrial function. Mitochondrial reactive oxygen species (ROS) generation may adversely affect PLT function and viability during storage, and refrigeration may mitigate these effects.
STUDY DESIGN AND METHODSPLTs were stored under two temperature conditions (RT, 20-24 degrees C; or 4 degrees C, 1-6 degrees C) and four storage durations (baseline [BL] and Days 3, 5, and 7). Mitochondrial respiration and maximal oxygen utilization were assessed with high-resolution respirometry. Mitochondrial ROS generation was assessed using a superoxide stain. Rotational thromboelastometry (ROTEM) was performed at BL and on Day 5 to assess PLT function. Collagen-induced PLT aggregation was measured by impedance aggregometry.
RESULTSMitochondrial ROS in 4 degrees C-stored samples were lower compared to RT and retained a greater capacity to generate ROS after activation. Mitochondrial respiration and maximal mitochondrial utilization was conserved in PLTs stored at 4 degrees C. ROTEM data demonstrated that net maximum clot firmness was higher in 4 degrees C samples compared to RT and prevented fibrinolysis. The aggregation response to collagen was preserved in the 4 degrees C samples versus RT-stored PLTs. Aggregation impairment correlated well with attenuated mitochondrial respiration and elevated production of intracellular mitochondrial ROS in the RT PLTs.
CONCLUSIONMitochondrial damage and ROS production may contribute to loss of PLT viability during storage, whereas cold storage is known to preserve PLT function. Here we demonstrate that 4 degrees C storage results in less oxidant stress and preserves mitochondrial function and potential compared to RT.
C1 [Bynum, James A.; Meledeo, M. Adam; Getz, Todd M.; Rodriguez, Armando C.; Aden, James K.; Cap, Andrew P.; Pidcoke, Heather F.] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX 78234 USA.
RP Pidcoke, HF (reprint author), US Army Inst Surg Res, Jbsa Ft Sam Houston, TX 78234 USA.
EM Heather.Pidcoke@terumobct.com
FU US Army Medical Research and Materiel Command
FX This study was conducted under a protocol reviewed and approved by the
US Army Medical Research and Materiel Command Institutional Review Board
and in accordance with the approved protocol. Support was received from
the US Army Medical Research and Materiel Command. The authors declare
that they have no conflicts of interest relevant to this article. The
opinions or assertions contained herein are the private views of the
author and are not to be construed as official or as reflecting the
views of the Department of the Army or the Department of Defense.
NR 48
TC 4
Z9 4
U1 1
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0041-1132
EI 1537-2995
J9 TRANSFUSION
JI Transfusion
PD MAR
PY 2016
VL 56
SU 1
SI SI
BP S76
EP S84
DI 10.1111/trf.13337
PG 9
WC Hematology
SC Hematology
GA DI2YJ
UT WOS:000373364800010
PM 27001365
ER
PT J
AU Cap, AP
Pidcoke, HF
Keil, SD
Staples, HM
Anantpadma, M
Carrion, R
Davey, RA
Frazer-Abel, A
Taylor, AL
Gonzales, R
Patterson, JL
Goodrich, RP
AF Cap, Andrew P.
Pidcoke, Heather F.
Keil, Shawn D.
Staples, Hilary M.
Anantpadma, Manu
Carrion, Ricardo, Jr.
Davey, Robert A.
Frazer-Abel, Ashley
Taylor, Audra L.
Gonzales, Richard
Patterson, Jean L.
Goodrich, Raymond P.
TI Treatment of blood with a pathogen reduction technology using
ultraviolet light and riboflavin inactivates Ebola virus in vitro
SO TRANSFUSION
LA English
DT Article
ID HERPES-SIMPLEX VIRUS; TRANSFUSION-TRANSMITTED MALARIA; NORMAL
HUMAN-FIBROBLASTS; ENHANCED REACTIVATION; PHOTOCHEMICAL INACTIVATION;
IRRADIATED ADENOVIRUS; DNA-DAMAGE; PLATELET; PLASMA; INFECTION
AB BACKGROUNDTransfusion of plasma from recovered patients after Ebolavirus (EBOV) infection, typically called convalescent plasma, is an effective treatment for active disease available in endemic areas, but carries the risk of introducing other pathogens, including other strains of EBOV. A pathogen reduction technology using ultraviolet light and riboflavin (UV+RB) is effective against multiple enveloped, negative-sense, single-stranded RNA viruses that are similar in structure to EBOV. We hypothesized that UV+RB is effective against EBOV in blood products without activating complement or reducing protective immunoglobulin titers that are important for the treatment of Ebola virus disease (EVD).
STUDY DESIGN AND METHODSFour in vitro experiments were conducted to evaluate effects of UV+RB on green fluorescent protein EBOV (EBOV-GFP), wild-type EBOV in serum, and whole blood, respectively, and on immunoglobulins and complement in plasma. Initial titers for Experiments 1 to 3 were 4.21 log GFP units/mL, 4.96 log infectious units/mL, and 4.23 log plaque-forming units/mL. Conditions tested in the first three experiments included the following: 1EBOV-GFP plus UV+RB; 2EBOV-GFP plus RB only; 3EBOV-GFP plus UV only; 4EBOV-GFP without RB or UV; 5virus-free control plus UV only; and 6virus-free control without RB or UV.
RESULTSUV+RB reduced EBOV titers to nondetectable levels in both nonhuman primate serum (2.8- to 3.2-log reduction) and human whole blood (3.0-log reduction) without decreasing protective antibody titers in human plasma.
CONCLUSIONOur in vitro results demonstrate that the UV+RB treatment efficiently reduces EBOV titers to below limits of detection in both serum and whole blood. In vivo testing to determine whether UV+RB can improve convalescent blood product safety is indicated.
C1 [Cap, Andrew P.; Pidcoke, Heather F.] US Army Inst Surg Res, Coagulat & Blood Res, Jbsa Ft Sam Houston, TX USA.
[Keil, Shawn D.; Gonzales, Richard; Goodrich, Raymond P.] Terumo BCT, Lakewood, CO USA.
[Staples, Hilary M.; Anantpadma, Manu; Carrion, Ricardo, Jr.; Davey, Robert A.; Patterson, Jean L.] Texas Biomed Res Inst, Dept Virol & Immunol, San Antonio, TX USA.
[Frazer-Abel, Ashley] Natl Jewish Lab, Complement Lab, Denver, CO USA.
[Taylor, Audra L.; Gonzales, Richard] US Army Blood Program, Jbsa Ft Sam Houston, TX USA.
RP Cap, AP (reprint author), US Army Inst Surg Res, Coagulat & Blood Res, San Antonio, TX 78234 USA.
EM andrew.p.cap.mil@mail.mil
FU NIH HHS [P51 OD011133]
NR 37
TC 3
Z9 3
U1 3
U2 10
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0041-1132
EI 1537-2995
J9 TRANSFUSION
JI Transfusion
PD MAR
PY 2016
VL 56
SU 1
SI SI
BP S6
EP S15
DI 10.1111/trf.13393
PG 10
WC Hematology
SC Hematology
GA DI2YJ
UT WOS:000373364800002
PM 27001363
ER
PT J
AU Gonzales, R
Taylor, AL
Atkinson, AJ
Malloy, WW
Macdonald, VW
Cap, AP
AF Gonzales, Richard
Taylor, Audra L.
Atkinson, Andrew J.
Malloy, Wilbur W.
Macdonald, Victor W.
Cap, Andrew P.
TI US Army blood program: 2025 and beyond
SO TRANSFUSION
LA English
DT Article
ID PLATELETS; STORAGE; VOLUNTEERS; SURVIVAL; 22-C; 4-C
AB In preparing to support the Army in 2025 and beyond, the Army Blood Program remains actively engaged with the research and advanced development of blood products and medical technology to improve blood safety and efficacy in conjunction with the US Army Medical Research and Materiel Command. National and International Blood Bank authorities have noted that the US Army research and development efforts in providing new blood products and improving blood safety operate on the cutting edge of technology and are transformational for the global blood industry. Over the past 14 years, the Army has transformed how blood support is provided and improved the survival rate of casualties. Almost every product or process developed by or for the military has found an application in treating civilian patients. Conflicts have many unwanted consequences; however, in times of conflict, one positive aspect is the identification of novel solutions to improve the safety and efficacy of the blood supply.
C1 [Gonzales, Richard] Terumo BCT, Grants Management & Govt Sponsored Res, 10810 West Collins Ave, Lakewood, CO 80215 USA.
[Gonzales, Richard; Taylor, Audra L.] US Army Blood Program, Jbsa Ft Sam Houston, TX USA.
[Atkinson, Andrew J.; Macdonald, Victor W.] US Army Med Res & Mat Command, US Army Med Mat Dev Act, Ft Detrick, MD USA.
[Malloy, Wilbur W.] US Army Med Res & Mat Command, US Army Med Mat Dev Act, Hemorrhage & Resuscitat Forward Surg Care Blood P, CDMRP, Ft Detrick, MD USA.
[Cap, Andrew P.] US Army Inst Surg Res, Coagulat & Blood Res, Jbsa Ft Sam Houston, TX USA.
RP Gonzales, R (reprint author), Terumo BCT, Grants Management & Govt Sponsored Res, 10810 West Collins Ave, Lakewood, CO 80215 USA.
EM Richard.gonzales@teru-mobct.com
NR 28
TC 0
Z9 0
U1 4
U2 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0041-1132
EI 1537-2995
J9 TRANSFUSION
JI Transfusion
PD MAR
PY 2016
VL 56
SU 1
SI SI
BP S85
EP S93
DI 10.1111/trf.13338
PG 9
WC Hematology
SC Hematology
GA DI2YJ
UT WOS:000373364800011
PM 27001366
ER
PT J
AU Pusateri, AE
Given, MB
Macdonald, VW
Homer, MJ
AF Pusateri, Anthony E.
Given, Michael B.
Macdonald, Victor W.
Homer, Mary J.
TI Comprehensive US government program for dried plasma development
SO TRANSFUSION
LA English
DT Article
ID SINGLE-DONOR PLASMA; MASSIVE TRANSFUSION; COMBAT; MULTICENTER;
OPERATIONS; MORTALITY; PRODUCT; QUALITY; RATIO; FIELD
AB Transfusion of plasma early after severe injury has been associated with improved survival. There are significant logistic factors that limit the ability to deliver plasma where needed in austere environments, such as the battlefield or during a significant civilian emergency. While some countries have access to more logistically supportable dried plasma, there is no such product approved for use in the United States. There is a clear need for a Food and Drug Administration (FDA)-approved dried plasma for military and emergency-preparedness uses, as well as for civilian use in remote or austere settings. The Department of Defense (DoD) and Biomedical Advanced Research and Development Authority are sponsoring development of three dried plasma products, incorporating different technologic approaches and business models. At the same time, the DoD is sponsoring prospective, randomized clinical studies on the prehospital use of plasma. These efforts are part of a coordinated program to provide a dried plasma for military and civilian applications and to produce additional information on plasma use so that, by the time we have an FDA-approved dried plasma, we will better understand how to use it.
C1 [Pusateri, Anthony E.] US Army Med Res & Mat Command, Ft Detrick, MD USA.
[Given, Michael B.] Off Naval Res, Arlington, VA 22217 USA.
[Macdonald, Victor W.] US Army Med Mat Command, US Army Med Mat Dev Act, Ft Detrick, MD USA.
[Homer, Mary J.] US Dept Hlth & Human Serv, Biomed Adv Res & Dev Author, Off Assistant Secretary Preparedness & Response, Washington, DC USA.
RP Pusateri, AE (reprint author), US Army Med Res & Mat Command, Combat Casualty Care Res Program, 504 Scott St,Bldg 722, Ft Detrick, MD 21702 USA.
EM anthony.e.pusateri.civ@mail.mil
NR 29
TC 1
Z9 1
U1 1
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0041-1132
EI 1537-2995
J9 TRANSFUSION
JI Transfusion
PD MAR
PY 2016
VL 56
SU 1
SI SI
BP S16
EP S23
DI 10.1111/trf.13331
PG 8
WC Hematology
SC Hematology
GA DI2YJ
UT WOS:000373364800003
PM 27001356
ER
PT J
AU Reisner, AT
Edla, S
Liu, JB
Rubin, JT
Thorsen, JE
Kittell, E
Smith, JB
Yeh, DD
Reifman, J
AF Reisner, Andrew T.
Edla, Shwetha
Liu, Jianbo
Rubin, John T.
Thorsen, Jill E.
Kittell, Erin
Smith, Jason B.
Yeh, Daniel D.
Reifman, Jaques
TI Muscle Oxygen Saturation Improves Diagnostic Association Between Initial
Vital Signs and Major Hemorrhage: A Prospective Observational Study
SO ACADEMIC EMERGENCY MEDICINE
LA English
DT Article
ID TISSUE; TRANSFUSION; PREDICTS; TRAUMA
AB ObjectivesDuring initial assessment of trauma patients, vital signs do not identify all patients with life-threatening hemorrhage. We hypothesized that a novel vital sign, muscle oxygen saturation (SmO2), could provide independent diagnostic information beyond routine vital signs for identification of hemorrhaging patients who require packed red blood cell (RBC) transfusion.
MethodsThis was an observational study of adult trauma patients treated at a Level I trauma center. Study staff placed the CareGuide 1100 tissue oximeter (Reflectance Medical Inc., Westborough, MA), and we analyzed average values of SmO2, systolic blood pressure (sBP), pulse pressure (PP), and heart rate (HR) during 10 minutes of early emergency department evaluation. We excluded subjects without a full set of vital signs during the observation interval. The study outcome was hemorrhagic injury and RBC transfusion 3 units in 24 hours (24-hr RBC 3). To test the hypothesis that SmO2 added independent information beyond routine vital signs, we developed one logistic regression model with HR, sBP, and PP and one with SmO2 in addition to HR, sBP, and PP and compared their areas under receiver operating characteristic curves (ROC AUCs) using DeLong's test.
ResultsWe enrolled 487 subjects; 23 received 24-hr RBC 3. Compared to the model without SmO2, the regression model with SmO2 had a significantly increased ROC AUC for the prediction of 3 units of 24-hr RBC volume, 0.85 (95% confidence interval [CI], 0.75-0.91) versus 0.77 (95% CI, 0.66-0.86; p < 0.05 per DeLong's test). Results were similar for ROC AUCs predicting patients (n = 11) receiving 24-hr RBC 9.
ConclusionsSmO(2) significantly improved the diagnostic association between initial vital signs and hemorrhagic injury with blood transfusion. This parameter may enhance the early identification of patients who require blood products for life-threatening hemorrhage.
C1 [Reisner, Andrew T.; Rubin, John T.; Thorsen, Jill E.; Kittell, Erin] Massachusetts Gen Hosp, Dept Emergency Med, Boston, MA 02114 USA.
[Edla, Shwetha; Liu, Jianbo; Smith, Jason B.; Reifman, Jaques] US Army Med Res & Mat Command, Dept Def Biotechnol, High Performance Comp Software Applicat Inst, Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA.
[Yeh, Daniel D.] Massachusetts Gen Hosp, Dept Surg, Boston, MA 02114 USA.
[Smith, Jason B.] OMNITEC Solut Inc, Natl Inst Mental Hlth Data Arch, Bethesda, MD USA.
RP Reifman, J (reprint author), US Army Med Res & Mat Command, Dept Def Biotechnol, High Performance Comp Software Applicat Inst, Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA.
EM jaques.reifman.civ@mail.mil
FU Combat Casualty Care Research Area Directorate of the U.S. Army Medical
Research and Materiel Command, Fort Detrick, MD
FX This work was supported by the Combat Casualty Care Research Area
Directorate of the U.S. Army Medical Research and Materiel Command, Fort
Detrick, MD. The study sponsors did not have any role in the study
design, data collection, analysis and interpretation of data, report
writing, or decision to submit the article for publication. The opinions
and assertions contained herein are the private views of the authors and
are not to be construed as official or as reflecting the views of the
U.S. Army or of the U.S. Department of Defense. This paper has been
approved for public release with unlimited distribution.
NR 10
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1069-6563
EI 1553-2712
J9 ACAD EMERG MED
JI Acad. Emerg. Med.
PD MAR
PY 2016
VL 23
IS 3
BP 353
EP 357
DI 10.1111/acem.12899
PG 5
WC Emergency Medicine
SC Emergency Medicine
GA DH9HF
UT WOS:000373106300016
PM 26743804
ER
PT J
AU McCreary, A
Ghosh, R
Amani, M
Wang, J
Duerloo, KAN
Sharma, A
Jarvis, K
Reed, EJ
Dongare, AM
Banerjee, SK
Terrones, M
Namburu, RR
Dubey, M
AF McCreary, Amber
Ghosh, Rudresh
Amani, Matin
Wang, Jin
Duerloo, Karel-Alexander N.
Sharma, Ankit
Jarvis, Karalee
Reed, Evan J.
Dongare, Avinash M.
Banerjee, Sanjay K.
Terrones, Mauricio
Namburu, Raju R.
Dubey, Madan
TI Effects of Uniaxial and Biaxial Strain on Few-Layered Terrace Structures
of MoS2 Grown by Vapor Transport
SO ACS NANO
LA English
DT Article
DE molybdenum disulfide; strain engineering; Raman; photoluminescence;
interlayer sliding; CVD; few-layer
ID TRANSITION-METAL DICHALCOGENIDES; MONOLAYER MOLYBDENUM-DISULFIDE;
FIELD-EFFECT TRANSISTORS; AUGMENTED-WAVE METHOD; RAMAN-SPECTROSCOPY;
ATOMIC LAYERS; ELECTRONIC-PROPERTIES; MULTILAYER MOS2; ULTRATHIN MOS2;
BILAYER MOS2
AB One of the most fascinating properties of molybdenum disulfide (MoS2) is its ability to be subjected to large amounts of strain without experiencing degradation. The potential of MoS2 mono- and few-layers in electronics, opto electronics, and flexible devices requires the fundamental understanding of their properties as a function of strain. While previous reports have studied mechanically exfoliated flakes, tensile strain experiments on chemical vapor deposition (CVD)-grown few-layered MoS2 have not been examined hitherto, although CVD is a state of the art synthesis technique with clear potential for scale-up processes. In this report, we used CVD-grown terrace MoS2 layers to study how the number and size of the layers affected the physical properties under uniaxial and biaxial tensile strain. Interestingly, we observed significant shifts in both the Raman in-plane mode (as high as -5.2 cm(-1)) and photoluminescence (PL) energy (as high as -88 meV) for the few-layered MoS2 under similar to 1.5% applied uniaxial tensile strain when compared to monolayers and few-layers of MoS2 studied previously. We also observed slippage between the layers which resulted in a hysteresis of the Raman and PL spectra during further applications of strain. Through DFT calculations, we contended that this random layer slippage was due to defects present in CVD-grown materials. This work demonstrates that CVD-grown few-layered MoS2 is a realistic, exciting material for tuning its properties under tensile strain.
C1 [McCreary, Amber; Amani, Matin; Dubey, Madan] US Army, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA.
[McCreary, Amber; Namburu, Raju R.] US Army, Res Lab, Computat & Informat Sci Directorate, Aberdeen Proving Ground, MD 21005 USA.
[McCreary, Amber; Terrones, Mauricio] Penn State Univ, Dept Phys, University Pk, PA 16802 USA.
[McCreary, Amber; Terrones, Mauricio] Penn State Univ, Ctr Dimens & Layered Mat 2, University Pk, PA 16802 USA.
[Terrones, Mauricio] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA.
[Terrones, Mauricio] Penn State Univ, Dept Chem, University Pk, PA 16802 USA.
[Ghosh, Rudresh; Sharma, Ankit] Univ Texas Austin, Microelect Res Ctr, Austin, TX 78758 USA.
[Jarvis, Karalee] Univ Texas Austin, Texas Mat Inst, Austin, TX 78758 USA.
[Wang, Jin; Dongare, Avinash M.] Univ Connecticut, Dept Mat Sci & Engn, Storrs, CT 06269 USA.
[Wang, Jin; Dongare, Avinash M.] Univ Connecticut, Inst Mat Sci, Storrs, CT 06269 USA.
[Duerloo, Karel-Alexander N.; Reed, Evan J.] Stanford Univ, Dept Mat Sci & Engn, Stanford, CA 94305 USA.
[Amani, Matin] Univ Calif Berkeley, Elect Engn & Comp Sci, Berkeley, CA 94720 USA.
[Amani, Matin] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Mat Sci, Berkeley, CA 94720 USA.
RP Dubey, M (reprint author), US Army, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA.; Terrones, M (reprint author), Penn State Univ, Dept Phys, University Pk, PA 16802 USA.; Terrones, M (reprint author), Penn State Univ, Ctr Dimens & Layered Mat 2, University Pk, PA 16802 USA.; Terrones, M (reprint author), Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA.; Terrones, M (reprint author), Penn State Univ, Dept Chem, University Pk, PA 16802 USA.
EM mut11@psu.edu; madan.dubey.civ@mail.mil
FU Army Research Laboratory [W911NF-14-2-0059]; U.S. Army Research
Laboratory (ARL) Director's Strategic Initiative (DSI) program on
interfaces in stacked 2D atomic layered materials; U.S. Army Research
Office MURI [W911NF-11-1-0362]; Army Research Office under STTR
[W911NF-14-P-0030]
FX This research was sponsored by the Army Research Laboratory. A.M., MA,
RN., and M.D. acknowledge the support of the U.S. Army Research
Laboratory (ARL) Director's Strategic Initiative (DSI) program on
interfaces in stacked 2D atomic layered materials. A.M. and M.T.
acknowledge the support of the U.S. Army Research Office MURI (Grant No.
W911NF-11-1-0362). R.G. and S.KB. thank the Army Research Office for
partial support of this work under STTR Award No. W911NF-14-P-0030. J.W.
and A.D. acknowledge that this research was accomplished under
Cooperative Agreement No. W911NF-14-2-0059 with the Army Research
Laboratory. A.M. thanks Zefang Wang from the Physics Department at The
Pennsylvania State University for her help with the differential
reflectance measurements. J.W. and A.D. acknowledge Professor Douglas E.
Spearot for giving us the implemented parameters of Mo-S in LAMMPS. The
views and conclusions contained in this document are those of the
authors and should not be interpreted as representing the official
policies, either expressed or implied, of the Army Research Laboratory
or the U.S. Government. The U.S. Government is authorized to reproduce
and distribute reprints for Government purposes notwithstanding any
copyright notation herein.
NR 72
TC 4
Z9 4
U1 21
U2 63
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1936-0851
EI 1936-086X
J9 ACS NANO
JI ACS Nano
PD MAR
PY 2016
VL 10
IS 3
BP 3186
EP 3197
DI 10.1021/acsnano.5b04550
PG 12
WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
Nanotechnology; Materials Science, Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA DH5TR
UT WOS:000372855400019
PM 26881920
ER
PT J
AU Ruzmetov, D
Zhang, KH
Stan, G
Kalanyan, B
Bhimanapati, GR
Eichfeld, SM
Burke, RA
Shah, PB
O'Regan, TP
Crowne, FJ
Birdwell, AG
Robinson, JA
Davydov, AV
Ivanov, TG
AF Ruzmetov, Dmitry
Zhang, Kehao
Stan, Gheorghe
Kalanyan, Berc
Bhimanapati, Ganesh R.
Eichfeld, Sarah M.
Burke, Robert A.
Shah, Pankaj B.
O'Regan, Terrance P.
Crowne, Frank J.
Birdwell, A. Glen
Robinson, Joshua A.
Davydov, Albert V.
Ivanov, Tony G.
TI Vertical 2D/3D Semiconductor Heterostructures Based on Epitaxial
Molybdenum Disulfide and Gallium Nitride
SO ACS NANO
LA English
DT Article
DE 2D material heterostructures; transition metal dichalcogenides; MoS2;
van der Waals epitaxy; GaN; conductive atomic force microscopy; vertical
transport
ID CHEMICAL-VAPOR-DEPOSITION; HEXAGONAL BORON-NITRIDE; SINGLE-LAYER MOS2;
MONOLAYER MOS2; ATOMIC LAYERS; TRANSISTORS; GRAPHENE; GROWTH
AB When designing semiconductor heterostructures, it is expected that epitaxial alignment will facilitate low-defect interfaces and efficient vertical transport. Here, we report lattice-matched epitaxial growth of molybdenum disulfide (MoS2) directly on gallium nitride (GaN), resulting in high-quality, unstrained, single-layer MoS2 with strict registry to the GaN lattice. These results present a promising path toward the implementation of high-performance electronic devices based on 2D/3D vertical heterostructures, where each of the 3D and 2D semiconductors is both a template for subsequent epitaxial growth and an active component of the device. The MoS2 monolayer triangles average 1 mu m along each side, with monolayer blankets (merged triangles) exhibiting properties similar to that of single-crystal MoS2 sheets. Photoluminescence, Raman, atomic force microscopy, and X-ray photoelectron spectroscopy analyses identified monolayer MoS2 with a prominent 20-fold enhancement of photoluminescence in the center regions larger triangles. The MoS2/GaN structures are shown to electrically conduct in the out-of-plane direction, confirming the potential of directly synthesized 2D/3D semiconductor heterostructures for vertical, current flow. Finally, we estimate a MoS2/GaN contact resistivity to be less than 4 Omega.cm(2) and current spreading in the MoS2 monolayer of approximately 1 mu m in diameter.
C1 [Ruzmetov, Dmitry; Burke, Robert A.; Shah, Pankaj B.; O'Regan, Terrance P.; Crowne, Frank J.; Birdwell, A. Glen; Ivanov, Tony G.] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
[Zhang, Kehao; Bhimanapati, Ganesh R.; Eichfeld, Sarah M.; Robinson, Joshua A.] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA.
[Zhang, Kehao; Bhimanapati, Ganesh R.; Eichfeld, Sarah M.; Robinson, Joshua A.] Penn State Univ, Ctr Dimens & Layered Mat 2, University Pk, PA 16802 USA.
[Ruzmetov, Dmitry; Stan, Gheorghe; Kalanyan, Berc; Davydov, Albert V.] Natl Inst Stand & Technol, Mat Measurement Lab, Gaithersburg, MD 20899 USA.
RP Ruzmetov, D; Ivanov, TG (reprint author), US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.; Ruzmetov, D (reprint author), Natl Inst Stand & Technol, Mat Measurement Lab, Gaithersburg, MD 20899 USA.
EM dmitry.a.ruzmetov.ctr@mail.mil; tony.g.ivanov.civ@mail.mil
FU U.S. Army Research Laboratory (ARL) Director's Strategic Initiative
(DSI); Material Genome Initiative; National Science Foundation
[DMR-1453924]
FX This work was supported by the U.S. Army Research Laboratory (ARL)
Director's Strategic Initiative (DSI) program on understanding and
exploiting the electronic interface in stacked 2D atomic layered
materials. D.R. and A.V.D. acknowledge the support of Material Genome
Initiative funding allocated to NIST. J.A.R. acknowledges support of the
National Science Foundation under Grant No. DMR-1453924. The authors are
grateful to Dr. Gavin Liu from NIST for performing the X-ray diffraction
measurements on the GaN substrates.
NR 37
TC 15
Z9 15
U1 39
U2 110
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1936-0851
EI 1936-086X
J9 ACS NANO
JI ACS Nano
PD MAR
PY 2016
VL 10
IS 3
BP 3580
EP 3588
DI 10.1021/acsnano.5b08008
PG 9
WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
Nanotechnology; Materials Science, Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA DH5TR
UT WOS:000372855400061
PM 26866442
ER
PT J
AU Wierzbicki, TA
Lee, IC
Gupta, AK
AF Wierzbicki, Teresa A.
Lee, Ivan C.
Gupta, Ashwani K.
TI Recent advances in catalytic oxidation and reformation of jet fuels
SO APPLIED ENERGY
LA English
DT Article
DE Catalytic combustion and fuel reformation; JP-8; Surrogate fuel; Sulfur
tolerance; Kinetic modeling; Hybrid combustion
ID VOLATILE ORGANIC-COMPOUNDS; NOBLE-METAL CATALYSTS; RH-NI CATALYSTS;
DIESEL-FUEL; HYDROGEN-PRODUCTION; LOW-TEMPERATURE; HIGHER HYDROCARBONS;
PEROVSKITE CATALYSTS; LIQUID HYDROCARBONS; REFORMING CATALYSTS
AB This paper provides a review of progress in catalytic conversion of JP-8 fuel and its surrogates made over the last decade. The effect of different types of catalyst and support materials, as well as different preparation methods, is discussed in detail. The derivation of kinetic models for computational studies is also examined. Particular attention is given to the development of sulfur tolerant catalysts and the mechanisms by which catalyst poisoning occurs, as this is an important obstacle to overcome for systems using sulfur-laden fuel. Suggestions for further research are offered. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Wierzbicki, Teresa A.; Gupta, Ashwani K.] Univ Maryland, Dept Mech Engn, 2181 Martin Hall,Campus Dr, College Pk, MD 20742 USA.
[Wierzbicki, Teresa A.; Lee, Ivan C.] US Army Res Lab, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
RP Gupta, AK (reprint author), Univ Maryland, Dept Mech Engn, 2181 Martin Hall,Campus Dr, College Pk, MD 20742 USA.
EM twierz@umd.edu; ivan.c.lee2.civ@mail.mil; akgupta@umd.edu
FU U.S. Army Research Laboratory
FX Support provided to Teresa A. Wierzbicki by the U.S. Army Research
Laboratory is gratefully acknowledged.
NR 109
TC 3
Z9 3
U1 5
U2 10
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0306-2619
EI 1872-9118
J9 APPL ENERG
JI Appl. Energy
PD MAR 1
PY 2016
VL 165
BP 904
EP 918
DI 10.1016/j.apenergy.2015.12.057
PG 15
WC Energy & Fuels; Engineering, Chemical
SC Energy & Fuels; Engineering
GA DH3GV
UT WOS:000372676400073
ER
PT J
AU DiPasquale, DM
Muza, SR
Gunn, AM
Li, Z
Zhang, Q
Harris, NS
Strangman, GE
AF DiPasquale, Dana M.
Muza, Stephen R.
Gunn, Andrea M.
Li, Zhi
Zhang, Quan
Harris, N. Stuart
Strangman, Gary E.
TI Evidence for cerebral edema, cerebral perfusion, and intracranial
pressure elevations in acute mountain sickness
SO BRAIN AND BEHAVIOR
LA English
DT Article
DE Altitude; exercise; hemoglobin; hypobaria; hypoxia; illness;
near-infrared spectroscopy; normobaric; optic nerve sheath
ID NEAR-INFRARED SPECTROSCOPY; NERVE SHEATH DIAMETER; COUNTERPOINT
HYPOBARIC HYPOXIA; TRAUMATIC BRAIN-INJURY; NORMOBARIC HYPOXIA;
HIGH-ALTITUDE; TERRESTRIAL ALTITUDE; DIFFERENT RESPONSES; EXPOSURE;
HEMATOMAS
AB IntroductionWe hypothesized that cerebral alterations in edema, perfusion, and/or intracranial pressure (ICP) are related to the development of acute mountain sickness (AMS).
MethodsTo vary AMS, we manipulated ambient oxygen, barometric pressure, and exercise duration. Thirty-six subjects were tested before, during and after 8 h exposures in (1) normobaric normoxia (NN; 300m elevation equivalent); (2) normobaric hypoxia (NH; 4400m equivalent); and (3) hypobaric hypoxia (HH; 4400m equivalent). After a passive 15 min ascent, each subject participated in either 10 or 60min of cycling exercise at 50% of heart rate reserve. We measured tissue absorption and scattering via radio-frequency near-infrared spectroscopy (NIRS), optic nerve sheath diameter (ONSD) via ultrasound, and AMS symptoms before, during, and after environmental exposures.
ResultsWe observed significant increases in NIRS tissue scattering of 0.350.11cm(-1) (P=0.001) in subjects with AMS (i.e., AMS+), consistent with mildly increased cerebral edema. We also noted a small, but significant increase in total hemoglobin concentrations with AMS+, 3.2 +/- 0.8molL(-1) (P<0.0005), consistent with increased cerebral perfusion. No effect of exercise duration was found, nor did we detect differences between NH and HH. ONSD assays documented a small but significant increase in ONSD (0.11 +/- 0.02mm; P<0.0005) with AMS+, suggesting mildly elevated ICP, as well as further increased ONSD with longer exercise duration (P=0.005).
ConclusionIn AMS+, we found evidence of cerebral edema, elevated cerebral perfusion, and elevated ICP. The observed changes were small but consistent with the reversible nature of AMS.
C1 [DiPasquale, Dana M.; Gunn, Andrea M.; Li, Zhi; Zhang, Quan; Strangman, Gary E.] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Psychiat, 149 13th St, Charlestown, MA 02129 USA.
[Muza, Stephen R.] US Army Res Inst Environm Med, Environm Med & Mil Performance Div, Natick, MA USA.
[Zhang, Quan; Strangman, Gary E.] Baylor Coll Med, Ctr Space Med, Houston, TX 77030 USA.
[Harris, N. Stuart] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Emergency Med,Div Wilderness Med, Boston, MA 02129 USA.
RP DiPasquale, DM (reprint author), Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Psychiat, 149 13th St, Charlestown, MA 02129 USA.
EM dipasquale.dana@gmail.com
FU DOD CDMRP program [W81-XWH1020199]
FX We gratefully acknowledge the support of the DOD CDMRP program and grant
W81-XWH1020199.
NR 57
TC 3
Z9 3
U1 3
U2 8
PU JOHN WILEY & SONS INC
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 2162-3279
J9 BRAIN BEHAV
JI Brain Behav.
PD MAR
PY 2016
VL 6
IS 3
AR e00437
DI 10.1002/brb3.437
PG 10
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA DH9TG
UT WOS:000373138200007
PM 27099800
ER
PT J
AU Li, C
Tian, R
Porter, W
Hammond, Z
Strachan-Olson, D
Kooker, AW
Olivas, J
Kessens, CC
Jayaram, K
Fearing, RS
Full, RJ
AF Li, C.
Tian, R.
Porter, W.
Hammond, Z.
Strachan-Olson, D.
Kooker, A. W.
Olivas, J.
Kessens, C. C.
Jayaram, K.
Fearing, R. S.
Full, R. J.
TI Cockroach-inspired self-righting robots
SO INTEGRATIVE AND COMPARATIVE BIOLOGY
LA English
DT Meeting Abstract
CT Annual Meeting of the Society-for-Integrative-and-Comparative-Biology
(SICB)
CY JAN 03-07, 2016
CL Portland, OR
SP Soc Integrat & Comparat Biol
C1 Univ Calif Berkeley, Berkeley, CA 94720 USA.
Army Res Lab, Adelphi, MD USA.
EM chen.li@berkeley.edu
NR 0
TC 0
Z9 0
U1 4
U2 4
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1540-7063
EI 1557-7023
J9 INTEGR COMP BIOL
JI Integr. Comp. Biol.
PD MAR
PY 2016
VL 56
SU 1
MA P3.108
BP E323
EP E323
PG 1
WC Zoology
SC Zoology
GA DH0FJ
UT WOS:000372457601650
ER
PT J
AU Levy, G
Elkas, J
Armstrong, AY
Nieman, LK
AF Levy, Gary
Elkas, John
Armstrong, Alicia Y.
Nieman, Lynnette K.
TI Endometrial Effects of Prolonged Therapy with the Selective Progesterone
Receptor Modulator Ulipristal Acetate A Case Report
SO JOURNAL OF REPRODUCTIVE MEDICINE
LA English
DT Article
DE contraceptive agents; Ella norpregnadiene; endometrial hyperplasia;
Esmya; fibroid; fibroids, uterine; leiomyoma; progesterone receptor;
selective progesterone receptor modulator; ulipristal acetate
ID RANDOMIZED CONTROLLED-TRIAL; PLACEBO-CONTROLLED TRIAL; UTERINE
LEIOMYOMATA; MIFEPRISTONE RU486; ASOPRISNIL; FIBROIDS; WOMEN; MORPHOLOGY
AB BACKGROUND: Prolonged exposure to a selective progesterone receptor modulator (ulipristal acetate) in a patient with benign metastasizing leiomyoma did not result in endometrial hyperplasia or neoplasia.
CASE: A woman with history of benign metastasizing leiomyoma underwent medical treatment for 5 years with ulipristal acetate. Endometrial biopsies were performed at established intervals to monitor for intraepithelial neoplasia or progesterone receptor modulator associated endometrial changes (PAECs). The patient tolerated UPA therapy well; there was no evidence of hyperplasia or proliferative changes associated with progesterone-associated endometrial changes.
CONCLUSION: In this case prolonged exposure to ulipristal acetate did not result in premalignant or malignant endometrial pathology.
C1 Tripler Army Med Ctr, Dept Reprod Endocrinol & Infertil, Honolulu, HI 96859 USA.
Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Reprod & Adult Endocrinol, NIH, Bethesda, MD USA.
Northern Virginia Pelv Surg Associates PC, Annandale, VA USA.
RP Levy, G (reprint author), Tripler Army Med Ctr, Reprod Med, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM garylevy1@gmail.com
NR 23
TC 0
Z9 0
U1 1
U2 1
PU SCI PRINTERS & PUBL INC
PI ST LOUIS
PA PO DRAWER 12425 8342 OLIVE BLVD, ST LOUIS, MO 63132 USA
SN 0024-7758
EI 1943-3565
J9 J REPROD MED
JI J. Reprod. Med.
PD MAR-APR
PY 2016
VL 61
IS 3-4
BP 159
EP 162
PG 4
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA DH5VK
UT WOS:000372860200011
PM 27172639
ER
PT J
AU Wang, YC
Wu, XM
Murray, C
Hamblin, M
Hooper, D
Dai, TH
AF Wang, Yucheng
Wu, Ximing
Murray, Clinton
Hamblin, Michael
Hooper, David
Dai, Tianhong
TI ANTIMICROBIAL BLUE LIGHT INACTIVATION OF GRAM-NEGATIVE PATHOGENS IN
BIOFILMS
SO LASERS IN SURGERY AND MEDICINE
LA English
DT Meeting Abstract
CT Annual Conference of the American-Society-for-Laser-Medicine-and-Surgery
CY MAR 30-APR 03, 2016
CL Boston, MA
SP Amer Soc Laser Med & Surg
C1 Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA.
Brooke Army Med Ctr, Houston, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0196-8092
EI 1096-9101
J9 LASER SURG MED
JI Lasers Surg. Med.
PD MAR
PY 2016
VL 48
SU 27
MA 154
BP 52
EP 53
PG 2
WC Dermatology; Surgery
SC Dermatology; Surgery
GA DH9GS
UT WOS:000373105000154
ER
PT J
AU Salyer, M
AF Salyer, Matt
TI And the Temple of Doom Town
SO MASSACHUSETTS REVIEW
LA English
DT Article
C1 [Salyer, Matt] US Mil Acad, West Point, NY USA.
RP Salyer, M (reprint author), US Mil Acad, West Point, NY USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU UNIV MASSACHUSETTS MASSACHUSETTS REVIEW
PI AMHERST
PA MEMORIAL HALL, AMHERST, MA 01003 USA
SN 0025-4878
J9 MASS REV
JI Mass. Rev.
PD SPR
PY 2016
VL 57
IS 1
BP 162
EP 175
PG 14
WC Literary Reviews
SC Literature
GA DI2HE
UT WOS:000373315500027
ER
PT J
AU Hoare, J
Duddu, R
Damavarapu, R
AF Hoare, John
Duddu, Raja
Damavarapu, Reddy
TI A Safe Scalable Process for Synthesis of
4,6-Bis(nitroimino)-1,3,5-triazinan-2-one (DNAM)
SO ORGANIC PROCESS RESEARCH & DEVELOPMENT
LA English
DT Article
ID THERMAL-DECOMPOSITION; PROPELLANT COMPONENT; ENERGETIC SALTS;
1-METHYL-2,4,5-TRINITROIMIDAZOLE; HETEROCYCLES
AB A modified and safe nitration process for production of 4,6-bis(nitroimino)-1,3,5-triazinan-2-one (DNAM), a high density high energy material, from melamine is described. Key to our strategy is to generate acetyl nitrate at 30-35 degrees C in the presence of the reactant melamine. The main advantage of our procedure is that it utilized a homogeneous reagent and a homogeneous reactant solution. This allowed control of the reaction exotherm much easier. The robustness of this process is successfully demonstrated by producing DNAM in multikilogram quantities using a 20 L reactor.
C1 [Hoare, John; Duddu, Raja] US Army, Leidos, ARDEC, B3028, Picatinny Arsenal, NJ 07806 USA.
[Damavarapu, Reddy] US Army, ARDEC, B3028, Picatinny Arsenal, NJ 07806 USA.
RP Duddu, R (reprint author), US Army, Leidos, ARDEC, B3028, Picatinny Arsenal, NJ 07806 USA.; Damavarapu, R (reprint author), US Army, ARDEC, B3028, Picatinny Arsenal, NJ 07806 USA.
EM raja.g.duddu.ctr@mail.mil
FU ARDEC [W15QKN-09-9-1001 BRG-152]
FX The authors gratefully acknowledge the support of ARDEC (Contract No:
W15QKN-09-9-1001 BRG-152). We thank Dr. Damon Parish, Naval Research
Laboratory, Washington, DC, for DNAM single crystal X-ray analysis.
NR 42
TC 0
Z9 0
U1 2
U2 6
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1083-6160
EI 1520-586X
J9 ORG PROCESS RES DEV
JI Org. Process Res. Dev.
PD MAR
PY 2016
VL 20
IS 3
BP 683
EP 686
DI 10.1021/acs.oprd.6b00010
PG 4
WC Chemistry, Applied; Chemistry, Organic
SC Chemistry
GA DH3CK
UT WOS:000372664900012
ER
PT J
AU Stuart, SC
Gray, B
Nevola, D
Su, L
Sachet, E
Ulrich, M
Dougherty, DB
AF Stuart, S. C.
Gray, B.
Nevola, D.
Su, L.
Sachet, E.
Ulrich, M.
Dougherty, D. B.
TI Magnetoelectric oxide films for spin manipulation in graphene
SO PHYSICA STATUS SOLIDI-RAPID RESEARCH LETTERS
LA English
DT Article
DE magnetoelectrics; spintronics; Cr2O3; films; graphene; spin field effect
transistors; scanned probe microscopy
ID RAY PHOTOELECTRON-SPECTROSCOPY; ROOM-TEMPERATURE; EXCHANGE BIAS
AB The challenge of creating a graphene spin field effect transistor (spin-FET) demands a magnetic gate dielectric material whose magnetization can be switched electrically. We have grown films of Cr2O3 on top of graphite and graphene by pulsed laser deposition that shows this crucial functionality. We demonstrate that the Cr2O3 films are magnetoelectric by poling them in combined electric and magnetic fields and then using magnetic force microscopy to observe spontaneous surface domain structure as a function of poling field. In addition, we show that the electric field created by a conducting AFM tip can be used to write magnetic patterns in the film that demonstrate the kind of continuous magnetoelectric control needed for a prototype spin-FET. (C) 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
C1 [Stuart, S. C.; Gray, B.; Nevola, D.; Su, L.; Ulrich, M.; Dougherty, D. B.] N Carolina State Univ, Dept Phys, Raleigh, NC 27695 USA.
[Sachet, E.] N Carolina State Univ, Dept Mat Sci & Engn, Box 7907, Raleigh, NC 27695 USA.
[Ulrich, M.] Army Res Off, Durham, NC 27703 USA.
[Stuart, S. C.] Aerosp Corp, Microelect Technol Dept, POB 92957, Los Angeles, CA 90009 USA.
RP Dougherty, DB (reprint author), N Carolina State Univ, Dept Phys, Raleigh, NC 27695 USA.
EM dbdoughe@ncsu.edu
FU Army Research Office [W911NF-04-D-0003]
FX We acknowledge useful discussions and technical assistance of Professor
J. P. Maria. This work was supported by the Army Research Office under
contract number W911NF-04-D-0003.
NR 28
TC 1
Z9 1
U1 11
U2 20
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 1862-6254
EI 1862-6270
J9 PHYS STATUS SOLIDI-R
JI Phys. Status Solidi-Rapid Res. Lett.
PD MAR
PY 2016
VL 10
IS 3
BP 242
EP 247
DI 10.1002/pssr.201510433
PG 6
WC Materials Science, Multidisciplinary; Physics, Applied; Physics,
Condensed Matter
SC Materials Science; Physics
GA DH9MD
UT WOS:000373119300007
ER
PT J
AU Korokhin, V
Shkuratov, Y
Kaydash, V
Basilevsky, A
Rohachova, L
Velikodsky, Y
Opanasenko, N
Videen, G
Stankevich, D
Kaluhina, O
AF Korokhin, Viktor
Shkuratov, Yuriy
Kaydash, Vadym
Basilevsky, Alexander
Rohachova, Larysa
Velikodsky, Yuri
Opanasenko, Nickolay
Videen, Gorden
Stankevich, Dmitry
Kaluhina, Olena
TI Characterization of of a photometric anomaly in lunar Mare Nubium
SO PLANETARY AND SPACE SCIENCE
LA English
DT Article
DE Moon; Surface; Mare Nubium; Photometry; Colorimetry; Mosaics; Phase
function; Surface anomaly; Chemical composition; Lunar Reconnaissance
Orbiter (LRO); Wide angle camera (WAC); Clementine UVVIS data
ID CLEMENTINE UVVIS DATA; RECONNAISSANCE ORBITER; TIO2 CONCENTRATIONS;
TITANIUM ABUNDANCE; SURFACE; MOON; SOIL; IRON; MINERALOGY; MATURITY
AB A novel approach of constructing photometrically seamless mosaics of reflectance, color-ratios, and phase-curve slopes using LROC WAC images has been developed, which can be used to map the photometric parameters of the lunar surface. The approach takes into account both geometric corrections with data on local topography and photometric conjunctions using our simple photometric model. New mosaics obtained with the technique allow more reliable studies of structural and chemical characteristics of the lunar surface. This approach has been applied to analyze the photometric anomaly (21.6 S, 17.7 W, similar to 40 km in size) in Mare Nubium detected earlier with our Earth-based observations. For each point of the scene the parameters were calculated using the least-square method for several tens of source WAC images. Clementine mosaics also were used in the analysis, e.g., in order to estimate the parameter of maturity degree I-s/FeO. The anomaly has low FeO and TiO2 abundance and reveals a higher slope of the phase function than surroundings. Thermal data from LRO Diviner measurements do not show anomalies in this region. We consider this area as a shallow flooding of an elevated formation of highland composition, the material of which could have been excavated and mixed up with upper layers of the lunar surface through meteoroid impacts. The anomalous behavior of the phase function can be explained by the difference of surface structure in the anomaly and surrounding regions on the scale of less than several centimeters. This may be due to larger quantities of small fragments of rocks and clumps on the surface and/or the presence of agglomerates having open structure. (c) 2016 Elsevier Ltd. All rights reserved.
C1 [Korokhin, Viktor; Shkuratov, Yuriy; Kaydash, Vadym; Rohachova, Larysa; Velikodsky, Yuri; Opanasenko, Nickolay; Stankevich, Dmitry; Kaluhina, Olena] Kharkiv VN Karazin Natl Univ, Inst Astron, 35 Sumskaya St, UA-61022 Kharkov, Ukraine.
[Basilevsky, Alexander] RAS, VI Vernadskii Inst Geochem & Analyt Chem, 19 Kosygin St, Moscow 117975, Russia.
[Velikodsky, Yuri] Natl Aviat Univ, Cosmonaut Komarov Ave 1, UA-03680 Kiev, Ukraine.
[Videen, Gorden] Army Res Lab AMSRL CI EM, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
[Videen, Gorden] Space Sci Inst, 4750 Walnut St Suite 205, Boulder, CO 80301 USA.
RP Korokhin, V (reprint author), Kharkiv VN Karazin Natl Univ, Inst Astron, 35 Sumskaya St, UA-61022 Kharkov, Ukraine.
EM dslpp@astron.kharkov.ua
OI Korokhin, Viktor/0000-0002-1911-3422; Velikodsky,
Yuri/0000-0002-8219-128X; Rohachova, Larysa/0000-0002-8830-2390
FU NASA [NNX11AB25G]
FX The authors gratefully acknowledge the research support from NASA Grant
NNX11AB25G Lunar Advanced Science and Exploration Research (LASER)
"Imaging photometric and polarimetric remote sensing of the Moon". The
authors thank the SELENE(KAGUYA) TC team and the SELENE Data Archive for
providing the SELENE(KAGUYA) data. SELENE is a Japanese mission
developed and operated by JAXA.
NR 73
TC 3
Z9 3
U1 3
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0032-0633
J9 PLANET SPACE SCI
JI Planet Space Sci.
PD MAR
PY 2016
VL 122
BP 70
EP 87
DI 10.1016/j.pss.2016.01.011
PG 18
WC Astronomy & Astrophysics
SC Astronomy & Astrophysics
GA DH4RS
UT WOS:000372773700008
ER
PT J
AU Nelson, N
Asplund, CA
AF Nelson, Nicole
Asplund, Chad A.
TI Exercise Testing: Who, When, and Why?
SO PM&R
LA English
DT Review
ID AMERICAN-HEART-ASSOCIATION; SCIENTIFIC STATEMENT; FUNCTIONAL-CAPACITY;
CLINICAL CARDIOLOGY; CARDIOPULMONARY; REHABILITATION; PREVENTION;
COMMITTEE; FAILURE; PROTOCOLS
AB There are different modalities of exercise testing that can provide valuable information to physicians about patient and athlete fitness and cardiopulmonary status. Cardiopulmonary exercise testing (CPX) is a form of exercise testing that measures ventilatory and gas exchange, heart rate, electrocardiogram, and blood pressures to provide detailed information on the cardiovascular, pulmonary, and muscular systems. This testing allows an accurate quantification of functional capacity/measure of exercise tolerance, diagnosis of cardiopulmonary disease, disease-progression monitoring or response to intervention, and the prescription of exercise and training. CPX directly measures inhaled and exhaled ventilator gases to determine the maximal oxygen uptake, which reflects the body's maximal use of oxygen and defines the limits of the cardiopulmonary system.
CPX is the ideal modality to evaluate causes of exertional fatigue and dyspnea, especially in complex cases in which the etiology could be cardiac, pulmonary, or deconditioning. Exercise tolerance has become an important outcome measure in patients with chronic obstructive pulmonary disease and congestive heart failure, as well as other chronic diseases, and is a well recognized predictor of mortality. Older athletes or those with underlying medical conditions could benefit from exercise testing for risk stratification and clearance to participate, as well as to help set their training zones and determine their functional limitations.
C1 [Nelson, Nicole] Eisenhower Army Med Ctr, Dept Family Med, Ft Gordon, GA USA.
[Asplund, Chad A.] Georgia So Univ, Dept Hlth & Kinesiol, Statesboro, GA 30458 USA.
RP Asplund, CA (reprint author), Georgia So Univ, Dept Hlth & Kinesiol, Statesboro, GA 30458 USA.
EM chad.asplund@gmail.com
NR 36
TC 0
Z9 0
U1 4
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1934-1482
EI 1934-1563
J9 PM&R
JI PM&R
PD MAR
PY 2016
VL 8
IS 3
SU S
BP S16
EP S23
DI 10.1016/j.pmrj.2015.10.019
PG 8
WC Rehabilitation; Sport Sciences
SC Rehabilitation; Sport Sciences
GA DH5UZ
UT WOS:000372858900003
PM 26972264
ER
PT J
AU Bahder, TB
AF Bahder, Thomas B.
TI Transfer of spatial reference frame using singlet states and classical
communication
SO QUANTUM INFORMATION PROCESSING
LA English
DT Article
DE Quantum algorithm; Reference frame transfer; Quantum orientation
ID LUMINOUS ETHER; INTERFEROMETER; INFORMATION; ROTATION
AB A simple protocol is described for transferring spatial orientation from Alice to Bob (two spatially separated observers). The two observers are assumed to share quantum singlet states and classical communication. The protocol assumes that Alice and Bob have complete free will (measurement independence) and is based on maximizing the Shannon mutual information between Alice and Bob's measurement outcomes. Repeated use of this protocol for each spatial axis of Alice allows transfer of a complete three-dimensional reference frame, up to inversion of each of the axes. The technological complexity of this protocol is similar to that needed for BB84 quantum key distribution and hence is much simpler to implement than recently proposed schemes for transmission of reference frames. A second protocol based on a Bayesian formalism is also discussed.
C1 [Bahder, Thomas B.] US Army, RDECOM, Aviat & Missile Res Dev & Engn Ctr, Charles M Bowden Lab, Redstone Arsenal, AL 35898 USA.
RP Bahder, TB (reprint author), US Army, RDECOM, Aviat & Missile Res Dev & Engn Ctr, Charles M Bowden Lab, Redstone Arsenal, AL 35898 USA.
EM thomas.bahder@us.army.mil
NR 41
TC 1
Z9 1
U1 2
U2 5
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1570-0755
EI 1573-1332
J9 QUANTUM INF PROCESS
JI Quantum Inf. Process.
PD MAR
PY 2016
VL 15
IS 3
SI SI
BP 1069
EP 1080
DI 10.1007/s11128-015-1212-9
PG 12
WC Physics, Multidisciplinary; Physics, Mathematical
SC Physics
GA DH6BX
UT WOS:000372877100005
ER
PT J
AU Tracy, FT
Walshire, LA
Corcoran, MK
AF Tracy, Fred T.
Walshire, Lucas A.
Corcoran, Maureen K.
TI SENSITIVITY STUDY OF INPUT PARAMETERS FOR SEEPAGE FLOW SIMULATIONS USING
PARALLEL COMPUTERS
SO SCALABLE COMPUTING-PRACTICE AND EXPERIENCE
LA English
DT Article
DE high performance computing; sensitivity analysis; finite element method;
seepage flow modeling
ID MODELS
AB This paper describes a comprehensive sensitivity study that was performed using high performance parallel computers to understand the importance of input parameters to a transient partially saturated finite element seepage analysis for a levee with separate soil layers of sand, silty sand, and clay. Seepage flow in this paper refers to the type of flow of water that occurred through the failed levees in New Orleans, Louisiana, USA, as a result of Hurricane Katrina. The input parameters tested were saturated hydraulic conductivity, volumetric compressibility, residual moisture content, saturated moisture content, and two van Genuchten unsaturated flow parameters. The output data compiled to show the sensitivity of the input parameters were the simulation times (days) to achieve 25%, 50%, and 75% of the steady-state values of pore pressure at the toe of the levee beneath its blanket, flow rate through the landside flux section, and the level of saturation in the levee. The use of high performance parallel computers enabled the running of thousands of scenarios using different values for the input variables. A sensitivity investigation of this magnitude has not been previously performed.
The results of this investigation indicated that the more sensitive soil parameters were the saturated hydraulic conductivity and the volumetric compressibility. The unsaturated van Genuchten parameters of the landside blanket had a larger than anticipated impact on the duration of time to achieve steady state. This practical example is an excellent success story for high performance computing in that running a given simulation for a couple of hours on thousands of processors in parallel replaced over a year's work using a PC.
C1 [Tracy, Fred T.] Erdc, Informat Technol Lab, Vicksburg, MS USA.
[Walshire, Lucas A.; Corcoran, Maureen K.] Erdc, GSL, Vicksburg, MS USA.
RP Tracy, FT (reprint author), Erdc, Informat Technol Lab, Vicksburg, MS USA.
NR 12
TC 0
Z9 0
U1 0
U2 0
PU UNIV VEST TIMISOARA, WEST UNIV TIMISOARA
PI TIMISOARA
PA BLVD VASILE PARVAN 4, TIMISOARA, TIMIS 300223, ROMANIA
SN 1895-1767
J9 SCALABLE COMPUT-PRAC
JI Scalable Comput.-Pract. Exp.
PD MAR
PY 2016
VL 17
IS 1
SI SI
BP 47
EP 60
PG 14
WC Computer Science, Software Engineering
SC Computer Science
GA DH8SV
UT WOS:000373067600005
ER
PT J
AU Dhall, R
Seyler, K
Li, Z
Wickrarnaratne, D
Neupane, MR
Chatzakis, I
Kosmowska, E
Lake, RK
Xu, XD
Cronin, SB
AF Dhall, Rohan
Seyler, Kyle
Li, Zhen
Wickrarnaratne, Darshana
Neupane, Mahesh R.
Chatzakis, Ioannis
Kosmowska, Ewa
Lake, Roger K.
Xu, Xiaodong
Cronin, Stephen B.
TI Strong Circularly Polarized Photoluminescence from Multilayer MoS2
Through Plasma Driven Direct-Gap Transition
SO ACS PHOTONICS
LA English
DT Article
DE intercalation; symmetry breaking transition metal dichalcogenides;
circularly polarized photoluminescence
ID VALLEY POLARIZATION; METAL DICHALCOGENIDES; LAYER MOS2; DISULFIDE; SPIN
AB We report circularly polarized photoluminescence spectra taken from few layer MoS2 after treatment with a remotely generated oxygen plasma. Here, the oxygen plasma decouples the individual layers in MoS2 by perturbing the weak interlayer van der Waals forces without damaging the lattice structure. This decoupling causes a transition from an indirect to a direct band gap material, which causes a strong enhancement of the photoluminescence intensity. Furthermore, up to 80% circularly polarized photoluminescence is observed after plasma treatment of few layer MoS2 flakes, consistent with high spin polarization of the optically excited carriers. A strong degree of polarization continues up to room temperature, further indicating that the quality of the crystal does not suffer degradation due to the oxygen plasma exposure. Our results show that the oxygen plasma treatment not only engineers the van der Waals separation in these TMDC multilayers for enhanced PL quantum yields, but also produces high quality multilayer samples for strong circularly polarized emission, which offers the benefit of layer index as an additional degree of freedom, absent in monolayer MoS2.
C1 [Dhall, Rohan; Li, Zhen; Chatzakis, Ioannis; Cronin, Stephen B.] Univ So Calif, Ming Hsieh Dept Elect Engn, Los Angeles, CA 90089 USA.
[Seyler, Kyle; Xu, Xiaodong] Univ Washington, Dept Phys, Seattle, WA 98105 USA.
[Wickrarnaratne, Darshana; Lake, Roger K.] Univ Calif Riverside, Dept Elect & Comp Engn, Riverside, CA 92521 USA.
[Neupane, Mahesh R.] Us Army Res Lab, RDRL WMM G, Baltimore, MD 21001 USA.
[Kosmowska, Ewa] XEI Sci, Redwood City, CA 94063 USA.
RP Cronin, SB (reprint author), Univ So Calif, Ming Hsieh Dept Elect Engn, Los Angeles, CA 90089 USA.
EM scronin@usc.edu
OI Li, Zhen/0000-0003-0886-2994
FU DOE [DE-FG02-07ER46376]; National Science Foundation (NSF) [1307671];
FAME, one of six centers of STARnet, a Semiconductor Research
Corporation program - MARCO; NSF [ACI-1053575]; DARPA; [DE-SC0012509]
FX The experimental portion of this work carried out at USC was supported
by DOE Award No. DE-FG02-07ER46376. The work at UW is supported by
DE-SC0012509. The theoretical and computational work was supported by
the National Science Foundation (NSF) Grant No. 1307671 and FAME, one of
six centers of STARnet, a Semiconductor Research Corporation program
sponsored by MARCO and DARPA. The computational work used the Extreme
Science and Engineering Discovery Environment (XSEDE), which is
supported by NSF, Grant No. ACI-1053575.
NR 17
TC 1
Z9 1
U1 14
U2 35
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 2330-4022
J9 ACS PHOTONICS
JI ACS Photonics
PD MAR
PY 2016
VL 3
IS 3
BP 310
EP 314
DI 10.1021/acsphotonics.5b00593
PG 5
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary;
Optics; Physics, Applied; Physics, Condensed Matter
SC Science & Technology - Other Topics; Materials Science; Optics; Physics
GA DH0MY
UT WOS:000372479500002
ER
PT J
AU Francis, M
AF Francis, Michael
TI Opinion: The NEPA and Major Water Resource Planning for the Future.
What's the problem? Analysis Paralysis
SO ENVIRONMENTAL PRACTICE
LA English
DT Editorial Material
AB Federal water resources development planning and the associated environmental assessment processes have been very complex and expensive. Federal water resource agencies are reassessing approaches to planning, with the support of our leadership and legislators, which encourages National Environmental Policy Act (NEPA) practitioners to apply the Council on Environmental Quality guidance to improve NEPA and to work with regulating agencies to streamline efforts and provide reasonable levels of information adequate for risk informed decision making.
C1 [Francis, Michael] US Army Corps Engineers, 201 North Third Ave, Walla Walla, WA 99362 USA.
RP Francis, M (reprint author), US Army Corps Engineers, 201 North Third Ave, Walla Walla, WA 99362 USA.
EM Michael.Francis@usace.army.mil
NR 0
TC 0
Z9 0
U1 8
U2 10
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 1466-0466
EI 1466-0474
J9 ENVIRON PRAC
JI Environ. Pract.
PD MAR
PY 2016
VL 18
IS 1
BP 69
EP 71
DI 10.1017/S1466046615000423
PG 3
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA DG8SF
UT WOS:000372353200008
ER
PT J
AU Tate, R
Conti, G
Farmer, A
Sobiesk, E
AF Tate, Ryan
Conti, Gregory
Farmer, Alexander
Sobiesk, Edward
TI Evaluating Adversarial Interfaces An Automated Approach
SO IEEE TECHNOLOGY AND SOCIETY MAGAZINE
LA English
DT Article
C1 [Tate, Ryan] US Army, Cyber Sch, Ft Gordon, GA USA.
[Conti, Gregory; Sobiesk, Edward] Army Cyber Inst, West Point, NY USA.
[Farmer, Alexander] US Army, Intelligence & Secur Command, Ft George G Meade, MD USA.
RP Tate, R (reprint author), US Army, Cyber Sch, Ft Gordon, GA USA.
NR 26
TC 0
Z9 0
U1 0
U2 0
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0278-0097
EI 1937-416X
J9 IEEE TECHNOL SOC MAG
JI IEEE Technol. Soc. Mag.
PD MAR
PY 2016
VL 35
IS 1
BP 56
EP 68
DI 10.1109/MTS.2016.2518249
PG 13
WC Engineering, Electrical & Electronic
SC Engineering
GA DH2ZA
UT WOS:000372654900013
ER
PT J
AU Stelmakh, V
Chan, WR
Ghebrebrhan, M
Senkevich, J
Joannopoulos, JD
Soljacic, M
Celanovic, I
AF Stelmakh, Veronika
Chan, Walker R.
Ghebrebrhan, Michael
Senkevich, Jay
Joannopoulos, John D.
Soljacic, Marin
Celanovic, Ivan
TI Sputtered Tantalum Photonic Crystal Coatings for High-Temperature Energy
Conversion Applications
SO IEEE TRANSACTIONS ON NANOTECHNOLOGY
LA English
DT Article
DE Energy conversion; high-temperature coatings; photonic crystal;
thermophotovoltaics
ID THERMOPHOTOVOLTAICS; RADIATION
AB Recent advances in photonic crystals have enabled high-efficiency thermophotovoltaic (TPV) energy conversion by allowing near-perfect spectral control. In this paper, photonic crystals fabricated in thick tantalum (Ta) coatings, sputtered onto a metallic substrate, were investigated as a potential replacement for photonic crystals fabricated in bulk refractory metal substrates in TPV applications. A 2-D photonic crystal was fabricated in a 30-mu m thick Ta sputtered coating using standard semiconductor processes as a proof-of-concept for a selective emitter/solar absorber. The reflectance of the fabricated photonic crystal coating was characterized before and after 1 h anneals at 700, 900, and 1100. degrees C, and after a 24 h anneal at 900. degrees C. To protect its surface during the anneals, a thin conformal hafnia (HfO2) layer was deposited by atomic layer deposition on the photonic crystal. The photonic crystal showed high spectral selectivity in good agreement with numerical simulations and sustained the anneals with minimal structural degradation or change in its optical properties. This study presents a promising alternative to bulk substrates as a relatively low-cost and easily integrated platform for nanostructured devices in high-temperature energy conversion systems.
C1 [Stelmakh, Veronika; Chan, Walker R.; Senkevich, Jay; Joannopoulos, John D.; Soljacic, Marin; Celanovic, Ivan] MIT, Inst Soldier Nanotechnol, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
[Ghebrebrhan, Michael] US Army, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA.
[Joannopoulos, John D.; Soljacic, Marin] MIT, Dept Phys, Ctr Mat Sci & Engn, Cambridge, MA 02139 USA.
[Joannopoulos, John D.; Soljacic, Marin] MIT, Elect Res Lab, Cambridge, MA 02139 USA.
RP Stelmakh, V (reprint author), MIT, Inst Soldier Nanotechnol, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
EM stelmakh@mit.edu
RI stelmakh, veronika/P-3098-2014
OI stelmakh, veronika/0000-0002-3099-1496
FU National Science Foundation (NSF) under NSF Award [ECS-0335765];
Solid-State Solar-Thermal Energy Conversion Center [S3TEC]; U.S.
Department of Energy, Office of Science, Basic Energy Sciences
[DE-SC0001299/DE-FG02-09ER46577]; U.S. Army Research Laboratory; U.S.
Army Research Office through the Institute for Soldier Nanotechnologies
[W911NF-13-D-0001]
FX Fabrication was done in part at the Nanostructures Laboratory at MIT and
at the Center for Nanoscale Systems at Harvard University, a Member of
the National Nanotechnology Infrastructure Network, supported by the
National Science Foundation (NSF) under NSF Award ECS-0335765.
Fabrication was supported by the Solid-State Solar-Thermal Energy
Conversion Center (S3TEC), an Energy Frontier Research Center supported
by the U.S. Department of Energy, Office of Science, Basic Energy
Sciences, under Award #DE-SC0001299/DE-FG02-09ER46577. This work was
also supported by the U.S. Army Research Laboratory and the U.S. Army
Research Office through the Institute for Soldier Nanotechnologies under
Contract #W911NF-13-D-0001. The review of this paper was arranged by
Associate Editor SIROMA Guest Editors.
NR 28
TC 1
Z9 1
U1 3
U2 7
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1536-125X
EI 1941-0085
J9 IEEE T NANOTECHNOL
JI IEEE Trans. Nanotechnol.
PD MAR
PY 2016
VL 15
IS 2
BP 303
EP 309
DI 10.1109/TNANO.2016.2522423
PG 7
WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology;
Materials Science, Multidisciplinary; Physics, Applied
SC Engineering; Science & Technology - Other Topics; Materials Science;
Physics
GA DH2XX
UT WOS:000372651800027
ER
PT J
AU Marathe, AR
Lawhern, VJ
Wu, DR
Slayback, D
Lance, BJ
AF Marathe, Amar R.
Lawhern, Vernon J.
Wu, Dongrui
Slayback, David
Lance, Brent J.
TI Improved Neural Signal Classification in a Rapid Serial Visual
Presentation Task Using Active Learning
SO IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
LA English
DT Article
DE Active learning; brain-computer interface; electroencephalography;
rapid-serial visual presentation
ID COUPLED COMPUTER VISION; FALSE DISCOVERY RATE; TARGET DETECTION;
PERFORMANCE; RESPONSES; SEARCH; TRIAGE
AB The application space for brain-computer interface (BCI) technologies is rapidly expanding with improvements in technology. However, most real-time BCIs require extensive individualized calibration prior to use, and systems often have to be recalibrated to account for changes in the neural signals due to a variety of factors including changes in human state, the surrounding environment, and task conditions. Novel approaches to reduce calibration time or effort will dramatically improve the usability of BCI systems. Active Learning (AL) is an iterative semi-supervised learning technique for learning in situations in which data may be abundant, but labels for the data are difficult or expensive to obtain. In this paper, we apply AL to a simulated BCI system for target identification using data from a rapid serial visual presentation (RSVP) paradigm to minimize the amount of training samples needed to initially calibrate a neural classifier. Our results show AL can produce similar overall classification accuracy with significantly less labeled data (in some cases less than 20%) when compared to alternative calibration approaches. In fact, AL classification performance matches performance of 10-fold cross-validation (CV) in over 70% of subjects when training with less than 50% of the data. To our knowledge, this is the first work to demonstrate the use of AL for offline electroencephalography (EEG) calibration in a simulated BCI paradigm. While AL itself is not often amenable for use in real-time systems, this work opens the door to alternative AL-like systems that are more amenable for BCI applications and thus enables future efforts for developing highly adaptive BCI systems.
C1 [Marathe, Amar R.; Lawhern, Vernon J.; Slayback, David; Lance, Brent J.] US Army, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA.
[Lawhern, Vernon J.] Univ Texas San Antonio, Dept Comp Sci, San Antonio, TX 78249 USA.
[Wu, Dongrui] Data Nova, Clifton Pk, NY 12065 USA.
RP Marathe, AR; Lawhern, VJ (reprint author), US Army, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA.
EM amar.marathe@case.edu; vernon.lawhern@utsa.edu
FU Office of the Secretary of Defense Autonomy Research Pilot Initiative
program [MIPR DWAM31168]; U.S. Army Research Laboratory
[W911NF-10-2-0022]; Oak Ridge Institute for Science and Engineering
[MIPR 4LDATBP033]
FX This project was supported by the Office of the Secretary of Defense
Autonomy Research Pilot Initiative program MIPR DWAM31168, by the U.S.
Army Research Laboratory, under Cooperative Agreement Number
W911NF-10-2-0022 and through the Oak Ridge Institute for Science and
Engineering under program MIPR 4LDATBP033. The views and the conclusions
contained in this document are those of the authors and should not be
interpreted as representing the official policies, either expressed or
implied, of the U.S. Government. A. R. Marathe and V. J. Lawhern
contributed equally to this work
NR 58
TC 2
Z9 2
U1 4
U2 11
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1534-4320
EI 1558-0210
J9 IEEE T NEUR SYS REH
JI IEEE Trans. Neural Syst. Rehabil. Eng.
PD MAR
PY 2016
VL 24
IS 3
BP 333
EP 343
DI 10.1109/TNSRE.2015.2502323
PG 11
WC Engineering, Biomedical; Rehabilitation
SC Engineering; Rehabilitation
GA DH1LU
UT WOS:000372546400003
PM 26600162
ER
PT J
AU Cordova, CB
Dembowski, SC
Johnson, MR
Combs, JJ
Svoboda, SJ
AF Cordova, Christopher B.
Dembowski, Scott C.
Johnson, Michael R.
Combs, John J.
Svoboda, Steven J.
TI Osteoid Osteoma of the Femoral Neck in Athletes: Two Case Reports
Differentiating From Femoral Neck Stress Injuries
SO SPORTS HEALTH-A MULTIDISCIPLINARY APPROACH
LA English
DT Article
DE osteoid osteoma; femoral neck stress fracture; athletes; bone tumor
ID LOWER-EXTREMITY; BONE-SCINTIGRAPHY; IMAGING FINDINGS; FRACTURES;
RECRUITS; CT
AB The diagnosis of an intra-articular osteoid osteoma can be a challenging and lengthy process, with reports of delayed diagnosis of greater than 2 years. In the young, athletic patient with an atraumatic onset of groin pain, an overuse injury or muscle strain is the most likely etiology. However, an overuse injury of femoral neck stress fracture must be identified because of the potentially disastrous outcome of fracture completion. The similar clinical presentation of a femoral neck stress fracture and intra-articular osteoid osteoma of the femoral neck can further delay the diagnosis of the osteoid osteoma. In a patient with these differential diagnoses that do not improve with a period of nonweightbearing activity, a more intensive workup must ensue. The purpose of this case report is to describe the initial presentations, subsequent follow-up, and imaging findings leading to the diagnosis of osteoid osteoma as well as to differentiate an osteoid osteoma from femoral neck stress injuries.
C1 [Cordova, Christopher B.; Combs, John J.] William Beaumont Army Med Ctr, Ft Bliss, TX USA.
[Dembowski, Scott C.] Moncrief Army Community Hosp, Columbia, SC USA.
[Johnson, Michael R.] Columbia Univ, Sch Med, New York, NY USA.
[Svoboda, Steven J.] Keller Army Community Hosp, West Point, NY USA.
RP Cordova, CB (reprint author), William Beaumont Army Med Ctr, 5005 North Piedras St, El Paso, TX 79920 USA.
EM christopher.b.cordova.mil@mail.mil
NR 25
TC 0
Z9 0
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1941-7381
EI 1941-0921
J9 SPORTS HEALTH
JI Sports Health
PD MAR-APR
PY 2016
VL 8
IS 2
BP 172
EP 176
DI 10.1177/1941738115614263
PG 5
WC Sport Sciences
SC Sport Sciences
GA DH1EN
UT WOS:000372527300011
PM 26517936
ER
PT J
AU van der Linden, WA
Schulze, CJ
Herbert, AS
Krause, TB
Wirchnianski, AA
Dye, JM
Chandran, K
Bogyo, M
AF van der Linden, Wouter A.
Schulze, Christopher J.
Herbert, Andrew S.
Krause, Tyler B.
Wirchnianski, Ariel A.
Dye, John M.
Chandran, Kartik
Bogyo, Matthew
TI Cysteine Cathepsin Inhibitors as Anti-Ebola Agents
SO ACS INFECTIOUS DISEASES
LA English
DT Article
DE filovirus; cathepsin inhibitor; Ebola virus; inhibition of host cell
entry
ID VIRUS ENTRY REQUIRES; NIEMANN-PICK C1; INFECTION; PROTEASES; DESIGN;
PROBE; E-64
AB The recent Ebola virus outbreak in western Africa highlights the need for novel therapeutics that target Ebola virus and other filoviruses. Filoviruses require processing by host cell-derived cysteine cathepsins for productive infection. Here we report the generation of a focused library of cysteine cathepsin inhibitors and subsequent screening to identify compounds with potent activity against viral entry and replication. Our top compounds show highly potent and broad-spectrum activity against cysteine cathepsins and were able to effectively block entry of Ebola and Marburg viruses. These agents are promising leads for development as antifilovirus therapeutics.
C1 [van der Linden, Wouter A.; Schulze, Christopher J.; Bogyo, Matthew] Stanford Univ, Sch Med, Dept Pathol, 300 Pasteur Dr, Stanford, CA 94305 USA.
[Herbert, Andrew S.; Wirchnianski, Ariel A.; Dye, John M.] US Army, Med Res Inst Infect Dis, Frederick, MD 21702 USA.
[Krause, Tyler B.; Chandran, Kartik] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA.
RP Bogyo, M (reprint author), Stanford Univ, Sch Med, Dept Pathol, 300 Pasteur Dr, Stanford, CA 94305 USA.; Chandran, K (reprint author), Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA.
EM kartik.chandran@einstein.yu.edu; mbogyo@stanford.edu
FU National Institutes of Health [R01 EB005011, R01 AI088027]; Defense
Threat Reduction Agency [CB3873]; Netherlands Organization for
Scientific Research (NWO)
FX We thank S. R. Lynch at the Stanford University Department of Chemistry
NMR facility for assistance. This work was supported by National
Institutes of Health Grants R01 EB005011 (to M.B.) and R01 AI088027 (to
K.C.) and the Defense Threat Reduction Agency funding CB3873 (J.M.D.).
W.A.v.d.L. was supported by a Rubicon fellowship from The Netherlands
Organization for Scientific Research (NWO).
NR 20
TC 3
Z9 3
U1 4
U2 6
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 2373-8227
J9 ACS INFECT DIS
JI ACS Infect. Dis.
PD MAR
PY 2016
VL 2
IS 3
BP 173
EP 179
DI 10.1021/acsinfecdis.5b00130
PG 7
WC Chemistry, Medicinal; Infectious Diseases
SC Pharmacology & Pharmacy; Infectious Diseases
GA DG6RF
UT WOS:000372213100002
PM 27347558
ER
PT J
AU Amata, E
Xi, HL
Colmenarejo, G
Gonzalez-Diaz, R
Cordon-Obras, C
Berlanga, M
Manzano, P
Erath, J
Roncal, NE
Lee, PJ
Leed, SE
Rodriguez, A
Sciotti, RJ
Navarro, M
Pollastri, MP
AF Amata, Emanuele
Xi, Hualin
Colmenarejo, Gonzalo
Gonzalez-Diaz, Rosario
Cordon-Obras, Carlos
Berlanga, Manuela
Manzano, Pilar
Erath, Jessey
Roncal, Norma E.
Lee, Patricia J.
Leed, Susan E.
Rodriguez, Ana
Sciotti, Richard J.
Navarro, Miguel
Pollastri, Michael P.
TI Identification of "Preferred" Human Kinase Inhibitors for Sleeping
Sickness Lead Discovery. Are Some Kinases Better than Others for
Inhibitor Repurposing?
SO ACS INFECTIOUS DISEASES
LA English
DT Article
DE preferred lead repurposing; Trypanosoma brucei; Trypanosoma cruzi;
Leishmania major; Plasmodium falciparum; Published Kinase Inhibitor Set
ID TRYPANOSOMA-BRUCEI; DRUG DISCOVERY; COMPOUND; POTENT
AB A kinase-targeting cell-based high-throughput screen (HTS) against Trypanosoma brucei was recently reported, and this screening set included the Published Kinase Inhibitor Set (PKIS). From the PKIS was identified 53 compounds with pEC(50) >= 6. Utilizing the published data available for the PKIS, a statistical analysis of these active antiparasitic compounds was performed, allowing identification of a set of human kinases having inhibitors that show a high likelihood for blocking T. brucei cellular proliferation in vitro. This observation was confirmed by testing other established inhibitors of these human kinases and by mining past screening campaigns at GlaxoSmithKline. Overall, although the parasite targets of action are not known, inhibitors of this set of human kinases displayed an enhanced hit rate relative to a random kinase-targeting HTS campaign, suggesting that repurposing efforts should focus primarily on inhibitors of these specific human kinases. We therefore term this statistical analysis-driven approach "preferred lead repurposing".
C1 [Amata, Emanuele; Pollastri, Michael P.] Northeastern Univ, Dept Chem & Chem Biol, 360 Huntington Ave, Boston, MA 02115 USA.
[Xi, Hualin] Pfizer Inc, Computat Sci Ctr Emphasis, 610 Main St, Cambridge, MA 02140 USA.
[Colmenarejo, Gonzalo; Berlanga, Manuela; Manzano, Pilar] GlaxoSmithKline, DDW, Tres Cantos Med Dev Campus, Tres Cantos 28760, Spain.
[Colmenarejo, Gonzalo; Berlanga, Manuela; Manzano, Pilar] GlaxoSmithKline, CIB, Tres Cantos Med Dev Campus, Tres Cantos 28760, Spain.
[Gonzalez-Diaz, Rosario; Cordon-Obras, Carlos; Navarro, Miguel] CSIC, Inst Parasitol & Biomed Lopez Neyra, Granada 18100, Spain.
[Erath, Jessey; Rodriguez, Ana] NYU, Sch Med, Div Parasitol, Dept Microbiol, 341 East 25th St New York, New York, NY 10010 USA.
[Rodriguez, Ana] NYU, Sch Med, Antiinfect Screening Core, New York, NY 10010 USA.
[Roncal, Norma E.; Lee, Patricia J.; Leed, Susan E.; Sciotti, Richard J.] Walter Reed Army Inst Res, Expt Therapeut, 2460 Linden Lane, Silver Spring, MD 20910 USA.
RP Pollastri, MP (reprint author), Northeastern Univ, Dept Chem & Chem Biol, 360 Huntington Ave, Boston, MA 02115 USA.
EM m.pollastri@neu.edu
OI Colmenarejo, Gonzalo/0000-0002-8249-4547; Rodriguez,
Ana/0000-0002-0060-3405
FU Tres Cantos Open Lab Foundation [TC-007]; National Institutes of Health
[R01AI082577, R01AI114685]
FX We acknowledge funding from The Tres Cantos Open Lab Foundation (TC-007)
and the National Institutes of Health (R01AI082577, R01AI114685).
NR 16
TC 1
Z9 1
U1 2
U2 4
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 2373-8227
J9 ACS INFECT DIS
JI ACS Infect. Dis.
PD MAR
PY 2016
VL 2
IS 3
BP 180
EP 186
DI 10.1021/acsinfecdis.5b00136
PG 7
WC Chemistry, Medicinal; Infectious Diseases
SC Pharmacology & Pharmacy; Infectious Diseases
GA DG6RF
UT WOS:000372213100003
PM 26998514
ER
PT J
AU Molohon, KJ
Blair, PM
Park, S
Doroghazi, JR
Maxson, T
Hershfield, JR
Flatt, KM
Schroeder, NE
Ha, T
Mitchell, DA
AF Molohon, Katie J.
Blair, Patricia M.
Park, Seongjin
Doroghazi, James R.
Maxson, Tucker
Hershfield, Jeremy R.
Flatt, Kristen M.
Schroeder, Nathan E.
Ha, Taekjip
Mitchell, Douglas A.
TI Plantazolicin Is an Ultranarrow-Spectrum Antibiotic That Targets the
Bacillus anthracis Membrane
SO ACS INFECTIOUS DISEASES
LA English
DT Article
DE ribosomally synthesized and post-translationally modified natural
product; antibiotic; mode of action; pathogen specific antibiotic;
membrane depolarization; Bacillus anthracis; anthrax; thiazole; oxazole
ID OPTICAL RECONSTRUCTION MICROSCOPY; CELL-WALL POLYSACCHARIDE;
STAPHYLOCOCCUS-AUREUS; GAMMA-PHAGE; AMYLOLIQUEFACIENS FZB42;
ESCHERICHIA-COLI; HIGH-SALINITY; IDENTIFICATION; SUBTILIS; DAPTOMYCIN
AB Plantazolicin (PZN) is a ribosomally synthesized and post-translationally modified natural product from Bacillus methylotrophicus FZB42 and Bacillus pumilus. Extensive tailoring to 12 of the 14 amino acid residues in the mature natural product endows PZN with not only a rigid, polyheterocyclic structure, but also antibacterial activity. Here we report the remarkably discriminatory activity of PZN toward Bacillus anthracis, which rivals a previously described gamma (gamma) phage lysis assay in distinguishing B. anthracis from other members of the Bacillus cereus group. We evaluate the underlying cause of this selective activity by measuring the RNA expression profile of PZN-treated B. anthracis, which revealed significant up-regulation of genes within the cell envelope stress response. PZN depolarizes the B. anthracis membrane like other cell envelope-acting compounds but uniquely localizes to distinct foci within the envelope. Selection and whole-genome sequencing of PZN-resistant mutants of B. anthracis implicate a relationship between the action of PZN and cardiolipin (CL) within the membrane. Exogenous CL increases the potency of PZN in wild type B. anthracis and promotes the incorporation of fluorescently tagged PZN in the cell envelope. We propose that PZN localizes to and exacerbates structurally compromised regions of the bacterial membrane, which ultimately results in cell lysis.
C1 [Molohon, Katie J.; Mitchell, Douglas A.] Univ Illinois, Dept Microbiol, Urbana, IL 61801 USA.
[Molohon, Katie J.; Doroghazi, James R.; Mitchell, Douglas A.] Univ Illinois, Carl R Woese Inst Genom Biol, Urbana, IL 61801 USA.
[Blair, Patricia M.; Maxson, Tucker; Ha, Taekjip; Mitchell, Douglas A.] Univ Illinois, Dept Chem, Urbana, IL 61801 USA.
[Park, Seongjin; Ha, Taekjip] Univ Illinois, Dept Phys, Urbana, IL 61801 USA.
[Park, Seongjin; Ha, Taekjip] Univ Illinois, Ctr Phys Living Cells, Urbana, IL 61801 USA.
[Hershfield, Jeremy R.] US Army, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA.
[Flatt, Kristen M.; Schroeder, Nathan E.] Univ Illinois, Dept Crop Sci, Urbana, IL 61801 USA.
[Ha, Taekjip] Howard Hughes Med Inst, Chevy Chase, MD 20815 USA.
RP Mitchell, DA (reprint author), Univ Illinois, Carl R Woese Inst Genom Biol, 1206 West Gregory Dr,Room 3105, Urbana, IL 61801 USA.
EM douglasm@illinois.edu
OI Blair, Patricia/0000-0001-6360-8206
FU U.S. National Institutes of Health [1R01 GM097142]; Defense Threat
Reduction Agency under USAMRIID [922141]; James R. Beck Graduate
Research Fellowship; ACS Medicinal Chemistry Predoctoral Fellowship;
Carle R. Woese Institute for Genomic Biology Fellows program
FX This work was supported by the U.S. National Institutes of Health (1R01
GM097142 to DAM) and the Defense Threat Reduction Agency under USAMRIID
(Project 922141). K.J.M., P.M.B., and J.R.D. were supported in part by a
James R. Beck Graduate Research Fellowship, an ACS Medicinal Chemistry
Predoctoral Fellowship, and the Carle R. Woese Institute for Genomic
Biology Fellows program, respectively. The fenders had no role in study
design, data collection and analysis, decision to publish, or
preparation of the manuscript. Opinions, interpretations, conclusions,
and recommendations are those of the authors and are not necessarily
endorsed by the U.S. Army.
NR 79
TC 4
Z9 4
U1 5
U2 7
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 2373-8227
J9 ACS INFECT DIS
JI ACS Infect. Dis.
PD MAR
PY 2016
VL 2
IS 3
BP 207
EP 220
DI 10.1021/acsinfecdis.5b00115
PG 14
WC Chemistry, Medicinal; Infectious Diseases
SC Pharmacology & Pharmacy; Infectious Diseases
GA DG6RF
UT WOS:000372213100006
PM 27152321
ER
PT J
AU Ruhl, DS
Tolisano, AM
Swiss, TP
Littlefield, PD
Golden, JB
AF Ruhl, Douglas S.
Tolisano, Anthony M.
Swiss, Tyler P.
Littlefield, Philip D.
Golden, J. Blake
TI Ceruminous adenocarcinoma: An analysis of the Surveillance Epidemiology
and End Results (SEER) database
SO AMERICAN JOURNAL OF OTOLARYNGOLOGY
LA English
DT Article
ID TUMORS
AB Objectives: Ceruminous adenocarcinoma is a rare malignancy. However, due to the paucity of cases, this has been difficult to study. Using a population-based national database, patient demographics and survival trends were analyzed to further elucidate the management of this malignancy.
Methods: The SEER database was queried for patients diagnosed with ceruminous adenocarcinoma between 1973 and 2010.
Results: Twenty-two patients were identified in the database. The average age of diagnosis was between 60 and 64 years. All of the patients underwent surgical resection of the primary malignancy. Eight patients (36%) also had postoperative radiation.
Conclusions: Ceruminous adenocarcinoma is uncommon but may not have as poor a prognosis as previously thought. Surgical resection alone appears to be a reasonable treatment option. Larger prospective studies are needed, but database analysis like this may provide clarity on the management of uncommon diseases. Published by Elsevier Inc.
C1 [Ruhl, Douglas S.; Tolisano, Anthony M.; Swiss, Tyler P.; Littlefield, Philip D.; Golden, J. Blake] Tripler Army Med Ctr, Dept Otolaryngol Head & Neck Surg, Honolulu, HI 96859 USA.
RP Ruhl, DS (reprint author), Tripler Army Med Ctr, Dept Otolaryngol Head & Neck Surg, Attn MCHK DSH, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM douglas.s.ruhl.mil@mail.mil
NR 10
TC 0
Z9 0
U1 0
U2 0
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0196-0709
EI 1532-818X
J9 AM J OTOLARYNG
JI Am. J. Otolaryngol.
PD MAR-APR
PY 2016
VL 37
IS 2
BP 70
EP 73
DI 10.1016/j.amjoto.2015.11.005
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA DG6RG
UT WOS:000372213200002
PM 26954854
ER
PT J
AU Baylan, JM
Chambers, JA
McMullin, N
Fletcher, JL
Sinha, I
Lundy, J
King, BT
Chan, RK
AF Baylan, Joseph M.
Chambers, J. Alan
McMullin, Neil
Fletcher, John L.
Sinha, Indranil
Lundy, Jonathan
King, Booker T.
Chan, Rodney K.
TI Reverse posterior interosseous flap for defects of the dorsal ulnar
wrist using previously burned and recently grafted skin
SO BURNS
LA English
DT Article
DE Hand burn; Posterior interosseous artery flap
ID LOCAL FASCIOCUTANEOUS FLAPS; RECONSTRUCTION; HAND
AB Background: In the severely burned patient, coverage of exposed bone in the dorsal ulnar wrist can be a difficult problem. This is especially challenging in patients with a high percentage total body surface area (TBSA) where donor flaps can be scarce. The use of previously burned and/or recently grafted skin as flaps is an option. It has been postulated that use of previously burned skin can result in higher rates of local or distant flap failures. The reverse posterior interosseous flap (PIF) is an axial flap, based on the retrograde posterior interosseous artery, to provide coverage of the hand. Here we describe utilization of the PIF, using previously burned and/or recently grafted skin for coverage of dorsal ulnar wrist defects.
Methods: This is a case series of three patients, with extensive burns (range 35-83% TBSA), where defects of the dorsal ulnar wrist necessitated coverage. Each patient underwent PIF(s) utilizing previously burned and/or grafted skin, all within three months after their initial burn event.
Results: Case 1: 28 year old male who suffered 35% TBSA via blast mechanism developed a chronic open wound over the dorsal ulnar wrist with exposed tendon. The patient successfully underwent a left PIF using previously grafted skin.
Case 2: 23 year old male with 83% TBSA. Bilateral ulnar styloids were exposed. PIFs were performed bilaterally, using previously burned and recently grafted skin. Coverage was successful but received leech therapy post-operatively for venous congestion.
Case 3: 37 year old male with 52% TBSA, with the most severe burns isolated to his bilateral upper extremities; the ulnar head was exposed. The posterior interroseous artery was explored and PIF was attempted, but there was no retrograde flow in the distal artery due to a deeper injury than previously recognized. The patient ultimately underwent a pedicled abdominal flap for coverage.
Conclusions: Defects of the distal ulnar wrist after deep and extensive burns can be problematic. Use of the reverse PIF using previously burned skin, even those that has just been recently grafted is a viable option for this difficult patient population. However, it may not be possible in all patients. Vigilance and early intervention for post-operative venous congestion are important. (C) 2015 Elsevier Ltd and ISBI. All rights reserved.
C1 [Baylan, Joseph M.] Scott & White Hosp Syst, Dept Surg, Temple, TX USA.
[McMullin, Neil; Fletcher, John L.; Lundy, Jonathan; King, Booker T.; Chan, Rodney K.] US Army Inst Surg Res, Clin Div, 3650 Chambers Pass, Ft Sam Houston, TX 78234 USA.
[McMullin, Neil; Fletcher, John L.; Lundy, Jonathan; King, Booker T.; Chan, Rodney K.] US Army Inst Surg Res, Burn Ctr, 3650 Chambers Pass, Ft Sam Houston, TX 78234 USA.
[Chambers, J. Alan] Walter Reed Natl Mil Med Ctr, Washington, DC USA.
[Sinha, Indranil] Brigham & Womens Hosp, Div Plast Surg, 75 Francis St, Boston, MA 02115 USA.
RP Chan, RK (reprint author), US Army Inst Surg Res, Clin Div, 3650 Chambers Pass, Ft Sam Houston, TX 78234 USA.; Chan, RK (reprint author), US Army Inst Surg Res, Burn Ctr, 3650 Chambers Pass, Ft Sam Houston, TX 78234 USA.
EM rodney.k.chan@us.army.mil
NR 17
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0305-4179
EI 1879-1409
J9 BURNS
JI Burns
PD MAR
PY 2016
VL 42
IS 2
BP E24
EP E30
DI 10.1016/j.burns.2015.06.020
PG 7
WC Critical Care Medicine; Dermatology; Surgery
SC General & Internal Medicine; Dermatology; Surgery
GA DG6FW
UT WOS:000372179600004
PM 26652146
ER
PT J
AU Schlussel, AT
Lustik, MB
Johnson, EK
Maykel, JA
Champagne, BJ
Damle, A
Ross, HM
Steele, SR
AF Schlussel, A. T.
Lustik, M. B.
Johnson, E. K.
Maykel, J. A.
Champagne, B. J.
Damle, A.
Ross, H. M.
Steele, S. R.
TI A nationwide assessment comparing nonelective open with minimally
invasive complex colorectal procedures
SO COLORECTAL DISEASE
LA English
DT Article
DE Nonelective; emergent; colorectal surgery; laparoscopy
ID RISK-ADJUSTED ANALYSIS; OPEN COLECTOMY; LAPAROSCOPIC COLECTOMY; SURGICAL
OUTCOMES; COLON-CANCER; ARTHROPLASTY; MANAGEMENT; MORTALITY; COLITIS;
DISEASE
AB AimThe use of minimally invasive colorectal surgery has increased greatly for both benign and malignant disease. Studies evaluating complex procedures have been largely limited to elective indications. We aimed to compare the outcome of a laparoscopic with an open transverse (TC) and total abdominal colectomy (TAC) in the nonelective setting.
MethodComparative analysis was made using the Nationwide Inpatient Sample (2008-11) of patients undergoing a nonelective TC or TAC identified by ICD-9-CM procedure codes. The risk-adjusted 30-day outcome was assessed using regression modelling accounting for patient characteristics, comorbidity and surgical procedure.
ResultsWe identified 7261 admissions including 818 laparoscopic and 6443 open procedures. The mean age of the population was 6517years and patients in the laparoscopic group were younger (56 +/- 20 vs 66 +/- 17years; P<0.05). The rate of a single complication was lower in the laparoscopic group (26% vs 38%; P<0.01), but this did not remain significant following a logistic regression analysis. Mortality was significantly lower in the laparoscopic group (3.1% vs 17%; P<0.01) and this remained true after adjusting for covariates (OR=0.62; P<0.05). Laparoscopic cases were associated with a shorter median length of stay (10 vs 13days; P<0.01) and hospital charge ($75758 vs $98833; P<0.01).
ConclusionA nonelective laparoscopic TC or TAC is associated with an equivalent complication rate and lower mortality compared with an open operation. The results should encourage surgeons with the appropriate skills to consider a laparoscopic approach for nonelective pathology requiring a complex colectomy.
C1 [Schlussel, A. T.] Brian Allgood Army Community Hosp, Dept Surg, Honolulu, HI USA.
[Lustik, M. B.] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA.
[Johnson, E. K.; Steele, S. R.] Madigan Army Med Ctr, Dept Surg, Ft Lewis, WA USA.
[Maykel, J. A.; Damle, A.] Univ Massachusetts, Mem Med Ctr, Div Colorectal Surg, Worcester, MA 01605 USA.
[Champagne, B. J.] Univ Hosp Cleveland, Case Med Ctr, Div Colorectal Surg, Cleveland, OH 44106 USA.
[Ross, H. M.] Temple Univ, Div Colorectal Surg, Philadelphia, PA 19122 USA.
RP Steele, SR (reprint author), Madigan Army Med Ctr, Colon & Rectal Surg, 9606 Piperhill Dr SE, Olympia, WA 98513 USA.
EM harkersteele@mac.com
NR 19
TC 1
Z9 1
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8910
EI 1463-1318
J9 COLORECTAL DIS
JI Colorectal Dis.
PD MAR
PY 2016
VL 18
IS 3
BP 301
EP 311
DI 10.1111/codi.13113
PG 11
WC Gastroenterology & Hepatology; Surgery
SC Gastroenterology & Hepatology; Surgery
GA DG4IN
UT WOS:000372036000015
PM 26362693
ER
PT J
AU Meisenheimer, ES
Bevis, ZJ
Tagawa, CW
Glorioso, JE
AF Meisenheimer, Erica S.
Bevis, Zachary J.
Tagawa, Chelsea W.
Glorioso, John E.
TI Drowning Injuries: An Update on Terminology, Environmental Factors, and
Management
SO CURRENT SPORTS MEDICINE REPORTS
LA English
DT Review
ID RESPIRATORY-DISTRESS-SYNDROME; COLD-WATER IMMERSION; CARDIAC-ARREST;
THERAPEUTIC HYPOTHERMIA; TEMPERATURE; SURFACTANT; PREVENTION;
GUIDELINES; SURVIVORS; CHILDREN
C1 [Meisenheimer, Erica S.; Bevis, Zachary J.; Tagawa, Chelsea W.; Glorioso, John E.] Tripler Army Med Ctr, Dept Family Med, 1 JarrettWhite Rd, Honolulu, HI 96859 USA.
RP Glorioso, JE (reprint author), Tripler Army Med Ctr, Dept Family Med, 1 JarrettWhite Rd, Honolulu, HI 96859 USA.
EM John.E.Glorioso.mil@mail.mil
NR 24
TC 0
Z9 0
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1537-890X
EI 1537-8918
J9 CURR SPORT MED REP
JI Curr. Sport. Med. Rep.
PD MAR-APR
PY 2016
VL 15
IS 2
BP 91
EP 93
DI 10.1249/JSR.0000000000000241
PG 3
WC Sport Sciences
SC Sport Sciences
GA DG2ML
UT WOS:000371901200009
PM 26963016
ER
PT J
AU Bell, AE
Falconi, A
AF Bell, Adriane E.
Falconi, Audrey
TI Acupuncture for the Treatment of Sports Injuries in an Austere
Environment
SO CURRENT SPORTS MEDICINE REPORTS
LA English
DT Review
ID LOW-BACK-PAIN; METAANALYSIS; BRAIN; OSTEOARTHRITIS; MANAGEMENT; KNEE;
STIMULATION; CARE
AB For sports injuries in an austere environment, narcotic pain medications are often unavailable or have limiting side effects like sedation or constipation. Meanwhile, nonsteroidal anti-inflammatory medications are frequently associated with gastrointestinal side effects and acetaminophen liver toxicity. A trained physician can rapidly use certain acupuncture techniques in an austere environment with potentially fewer side effects. Current medical literature notes low to moderate quality evidence for the use of acupuncture in lower back pain and osteoarthritis of the knee. There is emerging evidence for the use of acupuncture in traumatic brain injury. The U.S. military uses acupuncture in deployed settings to treat battlefield injuries with promising results. This article reviews the military's current use of acupuncture to treat injuries in a deployed setting and how this may translate to the care of a sports injury in an austere environment.
C1 [Bell, Adriane E.; Falconi, Audrey] US Army, Dept Family Med, Residency Fac, Tripler Army Med Ctr,Med Corps, Honolulu, HI USA.
RP Bell, AE (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM adriane.e.bell.mil@mail.mil
NR 35
TC 0
Z9 0
U1 4
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1537-890X
EI 1537-8918
J9 CURR SPORT MED REP
JI Curr. Sport. Med. Rep.
PD MAR-APR
PY 2016
VL 15
IS 2
BP 111
EP 115
DI 10.1249/JSR.0000000000000240
PG 5
WC Sport Sciences
SC Sport Sciences
GA DG2ML
UT WOS:000371901200013
PM 26963020
ER
PT J
AU Falconi, A
Flick, D
Ferguson, J
Glorioso, JE
AF Falconi, Audrey
Flick, David
Ferguson, Jason
Glorioso, John E.
TI Spinal Cord Injuries in Wave-Riding Sports: The Influence of
Environmental and Sport-Specific Factors
SO CURRENT SPORTS MEDICINE REPORTS
LA English
DT Review
ID SURFERS MYELOPATHY
AB Spinal cord injury is a nonfatal, catastrophic consequence of wave-riding sports. With surfing at the core, a multitude of activities have evolved that attempt to harness the power of ocean waves. The unique qualities of each wave-riding sport, in combination with the environmental factors of the ocean, define the risk for potential injuries. As wave-riding sports have become more advanced, athletes continue to push physical barriers. Taller waves are attempted while incorporating aerial maneuvers, all without protective equipment.
C1 [Falconi, Audrey; Flick, David; Ferguson, Jason; Glorioso, John E.] Tripler Army Med Ctr, Dept Family Med, Honolulu, HI 96859 USA.
RP Falconi, A (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM Audrey.e.falconi.mil@mail.mil
NR 19
TC 0
Z9 0
U1 1
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1537-890X
EI 1537-8918
J9 CURR SPORT MED REP
JI Curr. Sport. Med. Rep.
PD MAR-APR
PY 2016
VL 15
IS 2
BP 116
EP 120
DI 10.1249/JSR.0000000000000246
PG 5
WC Sport Sciences
SC Sport Sciences
GA DG2ML
UT WOS:000371901200014
PM 26963021
ER
PT J
AU Houston, JR
Dean, RG
AF Houston, J. R.
Dean, R. G.
TI Erosional Impacts of Modified Inlets, Beach Encroachment, and Beach
Nourishment on the East Coast of Florida
SO JOURNAL OF COASTAL RESEARCH
LA English
DT Article
DE Beach; erosion; inlets; beach nourishment; shoreline change
AB Most of the 21 inlets along the 588 km of sandy shoreline on the Florida east coast have been modified, primarily to improve navigation efficiency and safety. These modifications have usually caused significant downdrift shoreline erosion. Shoreline change data for the Florida east coast during the period from about 1869 to 1971, which was before widespread beach nourishment, are analyzed. Modified inlets during this period impacted about 25% of the shoreline and conservatively caused about 70% of the shoreline area recession and about 75-85% if counties are excluded that did not have modified inlets that caused net downdrift recession. During this same period of about 100 years, the remaining 75% of the shoreline advanced on average 46 m seaward. However, before Florida began regulating coastal construction, development often encroached on accreting shorelines, effectively masking much of the accretion. From about 1971 to 2007, a period of widespread beach nourishment, only about half of the nourishment sand was placed on eroding shorelines. About half was placed on shorelines that accreted or were stable from about 1869 to 1971 but where encroachment by development made the nourishment necessary. Over half of the recession caused by modified inlets still exists. The criteria used by the Florida Department of Environmental Protection to designate the erosional state of Florida east coast beaches was found to be problematic, since it currently designates 65% of this shoreline as eroding when only 20% eroded during the period of widespread beach nourishment from about 1971 to 2007.
C1 [Houston, J. R.] US Army, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Dean, R. G.] Univ Florida, Dept Civil & Coastal Engn, Gainesville, FL 32611 USA.
RP Houston, JR (reprint author), US Army, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
EM james.r.houston@usace.army.mil
NR 43
TC 0
Z9 0
U1 1
U2 4
PU COASTAL EDUCATION & RESEARCH FOUNDATION
PI LAWRENCE
PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA
SN 0749-0208
EI 1551-5036
J9 J COASTAL RES
JI J. Coast. Res.
PD MAR
PY 2016
VL 32
IS 2
BP 227
EP 240
DI 10.2112/JCOASTRES-D-15-00105.1
PG 14
WC Environmental Sciences; Geography, Physical; Geosciences,
Multidisciplinary
SC Environmental Sciences & Ecology; Physical Geography; Geology
GA DG4JK
UT WOS:000372038300001
ER
PT J
AU Cooper, SA
Huang, AA
Raskin, RE
Weng, HY
Scott-Moncrieff, JC
AF Cooper, S. A.
Huang, A. A.
Raskin, R. E.
Weng, H. -Y.
Scott-Moncrieff, J. C.
TI Clinical data, clinicopathologic findings and outcome in dogs with
amegakaryocytic thrombocytopenia and primary immune-mediated
thrombocytopenia
SO JOURNAL OF SMALL ANIMAL PRACTICE
LA English
DT Article
ID BONE-MARROW; PURPURA
AB OBJECTIVESThe aim of this study was to identify distinguishing characteristics between dogs diagnosed with amegakaryocytic thrombocytopenia and those diagnosed with presumed primary peripheral immune-mediated thrombocytopenia. Presenting clinical and clinicopathologic data and outcomes were compared between the two groups.
METHODSRetrospective study performed on seven client-owned dogs diagnosed with amegakaryocytic thrombocytopenia and 34 client-owned dogs with primary peripheral immune-mediated thrombocytopenia.
RESULTSAll dogs in the amegakaryocytic thrombocytopenia group were anaemic on presentation with a median haematocrit of 23% (range 94 to 36), while the primary peripheral immune-mediated thrombocytopoenia group had a median presenting haematocrit of 35% (range 10 to 53). Dogs with amegakaryocytic thrombocytopenia had a median of five (range 4 to 7) clinical signs of bleeding compared to a median of three (range 0 to 6) in the primary peripheral immune-mediated thrombocytopenia group with 86% (6 of 7) of amegakaryocytic thrombocytopenia dogs requiring a blood transfusion compared to 41% (14 of 34) of primary peripheral immune-mediated thrombocytopenia dogs. Six of the seven amegakaryocytic thrombocytopenia dogs did not survive to discharge, while only five of the 34 primary peripheral immune-mediated thrombocytopenia dogs did not survive to discharge.
CLINICAL SIGNIFICANCEThe clinical presentation of dogs with amegakaryocytic thrombocytopenia and primary peripheral immune-mediated thrombocytopenia is similar, but dogs with amegakaryocytic thrombocytopenia had a more severe clinical course compared to primary peripheral immune-mediated thrombocytopenia dogs. The prognosis for dogs with amegakaryocytic thrombocytopenia is poor.
C1 [Cooper, S. A.; Huang, A. A.; Scott-Moncrieff, J. C.] Purdue Univ, Coll Vet Med, Dept Vet Clin Sci, W Lafayette, IN 47907 USA.
[Raskin, R. E.; Weng, H. -Y.] Purdue Univ, Coll Vet Med, Dept Comparat Pathobiol, W Lafayette, IN 47907 USA.
[Cooper, S. A.] US Army Publ Hlth Command, Ft Bragg, NC 28307 USA.
RP Scott-Moncrieff, JC (reprint author), Purdue Univ, Coll Vet Med, Dept Vet Clin Sci, W Lafayette, IN 47907 USA.
EM scottmon@purdue.edu
NR 14
TC 0
Z9 0
U1 4
U2 9
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-4510
EI 1748-5827
J9 J SMALL ANIM PRACT
JI J. Small Anim. Pract.
PD MAR
PY 2016
VL 57
IS 3
BP 142
EP 147
DI 10.1111/jsap.12441
PG 6
WC Veterinary Sciences
SC Veterinary Sciences
GA DG4DP
UT WOS:000372021500005
PM 26799165
ER
PT J
AU Stewart, IJ
Faulk, TI
Sosnov, JA
Clemens, MS
Elterman, J
Ross, JD
Howard, JT
Fang, R
Zonies, DH
Chung, KK
AF Stewart, Ian J.
Faulk, Tarra I.
Sosnov, Jonathan A.
Clemens, Michael S.
Elterman, Joel
Ross, James D.
Howard, Jeffrey T.
Fang, Raymond
Zonies, David H.
Chung, Kevin K.
TI Rhabdomyolysis among critically ill combat casualties: Associations with
acute kidney injury and mortality
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article
DE Rhabdomyolysis; acute kidney injury; trauma; war; mortality
ID ACUTE-RENAL-FAILURE; TRAUMA PATIENTS; SERUM CREATININE; MARMARA
EARTHQUAKE; RIFLE CRITERIA; CRUSH SYNDROME; RISK-FACTORS; CARE;
MYOGLOBIN; SEVERITY
AB BACKGROUND Rhabdomyolysis has been associated with poor outcomes in patients with traumatic injury, especially in the setting of acute kidney injury (AKI). However, rhabdomyolysis has not been systematically examined in a large cohort of combat casualties injured in the wars in Iraq and Afghanistan.
METHODS We conducted a retrospective study of casualties injured during combat operations in Iraq and Afghanistan who were initially admitted to the intensive care unit from February 1, 2002, to February 1, 2011. Information on age, sex, Abbreviated Injury Scale (AIS) score, Injury Severity Score (ISS), mechanism of injury, shock index, creatine kinase, and serum creatinine were collected. These variables were examined via multivariate logistic and Cox regression analyses to determine factors independently associated with rhabdomyolysis, AKI, and death.
RESULTS Of 6,011 admissions identified, a total of 2,109 patients met inclusion criteria and were included for analysis. Rhabdomyolysis, defined as creatine kinase greater than 5,000 U/L, was present in 656 subjects (31.1%). Risk factors for rhabdomyolysis identified on multivariable analysis included injuries to the abdomen and extremities, increased ISS, male sex, explosive mechanism of injury, and shock index greater than 0.9. After adjustment, patients with rhabdomyolysis had a greater than twofold increase in the odds of AKI. In the analysis for mortality, rhabdomyolysis was significantly associated with death until AKI was added, at which point it lost statistical significance.
CONCLUSION We found that rhabdomyolysis is associated with the development of AKI in combat casualties. While rhabdomyolysis was strongly associated with mortality on the univariate model and in conjunction with both ISS and age, it was not associated with mortality after the inclusion of AKI. This suggests that the effect of rhabdomyolysis on mortality may be mediated by AKI.
LEVEL OF EVIDENCE Prognostic and epidemiologic study, level III.
C1 [Stewart, Ian J.; Faulk, Tarra I.] David Grant Med Ctr, Fairfield, CA USA.
[Stewart, Ian J.; Sosnov, Jonathan A.; Elterman, Joel; Zonies, David H.; Chung, Kevin K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Fang, Raymond] US Air Force Ctr Sustainment Trauma & Readiness S, Baltimore, MD USA.
[Sosnov, Jonathan A.; Clemens, Michael S.] San Antonio Mil Med Ctr, San Antonio, TX USA.
[Ross, James D.] Wilford Hall Ambulatory Surg Ctr, 59th Med Wing, San Antonio, TX USA.
[Howard, Jeffrey T.; Chung, Kevin K.] US Army Inst Surg Res, San Antonio, TX USA.
[Elterman, Joel] Univ Cincinnati, Med Ctr, Cincinnati, OH 45267 USA.
[Zonies, David H.] Oregon Hlth & Sci Univ, Portland, OR 97201 USA.
RP Stewart, IJ (reprint author), David Grant Med Ctr, Clin Invest Facil, 101 Bodin Circle Travis AFB, Fairfield, CA 94535 USA.
EM ian.stewart@us.af.mil
NR 31
TC 2
Z9 2
U1 6
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2163-0755
EI 2163-0763
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD MAR
PY 2016
VL 80
IS 3
BP 492
EP 498
DI 10.1097/TA.0000000000000933
PG 7
WC Critical Care Medicine; Surgery
SC General & Internal Medicine; Surgery
GA DF7XT
UT WOS:000371571900028
PM 26670111
ER
PT J
AU Griep, MH
Sandoz-Rosado, E
Tumlin, TM
Wetzel, E
AF Griep, Mark H.
Sandoz-Rosado, Emil
Tumlin, Travis M.
Wetzel, Eric
TI Enhanced Graphene Mechanical Properties through Ultrasmooth Copper
Growth Substrates
SO NANO LETTERS
LA English
DT Article
DE Graphene; breaking strength; electropolishing; 2D nanomaterial
ID CHEMICAL-VAPOR-DEPOSITION; HEXAGONAL BORON-NITRIDE; GRAIN-BOUNDARIES;
ELECTROPOLISHED COPPER; INTRINSIC STRENGTH; FILMS; TEMPERATURE; FOILS;
CU; DYNAMICS
AB The combination of extraordinary strength and stiffness in conjunction with exceptional electronic and thermal properties in lightweight two-dimensional materials has propelled graphene research toward a wide array of applications including flexible electronics and functional structural components. Tailoring graphene's properties toward a selected application requires precise control of the atomic layer growth process, transfer, and postprocessing procedures. To date, the mechanical properties of graphene are largely controlled through postprocess defect engineering techniques. In this work, we demonstrate the role of varied catalytic surface morphologies on the tailorability of subsequent graphene film quality and breaking strength, providing a mechanism to tailor the physical, electrical, and mechanical properties at the growth stage. A new surface planarization methodology that results in over a 99% reduction in Cu surface roughness allows for smoothness parameters beyond that reported to date in literature and clearly demonstrates the role of Cu smoothness toward a decrease in the formation of bilayer graphene defects, altered domain sizes, monolayer graphene sheet resistance values down to 120 Omega/rectangle and a 78% improvement in breaking strength. The combined electrical and mechanical enhancements achieved through this methodology allows for the direct growth of application quality flexible transparent conductive films with monolayer graphene.
C1 [Griep, Mark H.; Sandoz-Rosado, Emil; Tumlin, Travis M.; Wetzel, Eric] US Army, Res Lab, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA.
RP Griep, MH (reprint author), US Army, Res Lab, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA.
EM mark.h.griep.civ@mail.mil
FU U.S. Army Research Laboratory
FX Funding for this work was provided by the U.S. Army Research Laboratory.
This research was supported in part by an appointment to the
Postgraduate Research Participation Program at the U.S. Army Research
Laboratory administered by the Oak Ridge Institute for Science and
Education through an interagency agreement between the U.S. Department
of Energy and U.S. ARL.
NR 33
TC 8
Z9 8
U1 16
U2 50
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1530-6984
EI 1530-6992
J9 NANO LETT
JI Nano Lett.
PD MAR
PY 2016
VL 16
IS 3
BP 1657
EP 1662
DI 10.1021/acs.nanolett.5b04531
PG 6
WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied;
Physics, Condensed Matter
SC Chemistry; Science & Technology - Other Topics; Materials Science;
Physics
GA DG3CE
UT WOS:000371946300022
PM 26882091
ER
PT J
AU Sheremet, A
Davis, JR
Tian, M
Hanson, JL
Hathaway, KK
AF Sheremet, Alex
Davis, Justin R.
Tian, Miao
Hanson, Jeffrey L.
Hathaway, Kent K.
TI TRIADS: A phase-resolving model for nonlinear shoaling of directional
wave spectra
SO OCEAN MODELLING
LA English
DT Article
DE TRIADS; Directinal spectrum; Nonlinear; Hurricane Bill
ID SURFACE GRAVITY-WAVES; LINEAR ENERGY TRANSFER; INFRAGRAVITY WAVES;
SOLITARY WAVE; VARIABLE DEPTH; EVOLUTION; WATER; TRANSFORMATION;
PROPAGATION; ESTIMATOR
AB We investigate the performance of TRIADS, a numerical implementation of a phase-resolving, nonlinear, spectral model describing directional wave evolution in intermediate and shallow water. TRIADS simulations of shoaling waves generated by Hurricane Bill, 2009 are compared to directional spectral estimates based on observations collected at the Field Research Facility of the US Army Corps Of Engineers, at Duck, NC. Both the ability of the model to capture the processes essential to the nonlinear wave evolution, and the efficiency of the numerical implementations are analyzed and discussed. Published by Elsevier Ltd.
C1 [Sheremet, Alex; Davis, Justin R.; Tian, Miao] Univ Florida, ESSIE, 365 Weil Hall, Gainesville, FL 32611 USA.
[Hanson, Jeffrey L.; Hathaway, Kent K.] US Army Corps Engineers, Field Res Facil, Duck, NC USA.
RP Sheremet, A (reprint author), Univ Florida, ESSIE, 365 Weil Hall, Gainesville, FL 32611 USA.
EM alex.sheremet@essie.ufl.edu; justin.r.davis@essie.ufl.edu;
mtian04.18@ufl.edu; Jeffrey.L.Hanson@usace.army.mil; mtian04.18@ufl.edu
OI Davis, Justin/0000-0001-6407-5229
FU ONR [N00014-13-1-0620, N00014-10-1-0389, N00014-10-0805]
FX This research was supported by ONR Grants N00014-13-1-0620,
N00014-10-1-0389, and N00014-10-0805.
NR 58
TC 1
Z9 1
U1 1
U2 5
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1463-5003
EI 1463-5011
J9 OCEAN MODEL
JI Ocean Model.
PD MAR
PY 2016
VL 99
BP 60
EP 74
DI 10.1016/j.ocemod.2016.01.002
PG 15
WC Meteorology & Atmospheric Sciences; Oceanography
SC Meteorology & Atmospheric Sciences; Oceanography
GA DG0YT
UT WOS:000371792800005
ER
PT J
AU Kenow, KP
Benjamin, GL
Schlagenhaft, TW
Nissen, RA
Stefanski, M
Wege, GJ
Jutila, SA
Newton, TJ
AF Kenow, K. P.
Benjamin, G. L.
Schlagenhaft, T. W.
Nissen, R. A.
Stefanski, M.
Wege, G. J.
Jutila, S. A.
Newton, T. J.
TI Process, Policy, and Implementation of Pool-Wide Drawdowns on the Upper
Mississippi River: A Promising Approach for Ecological Restoration of
Large Impounded Rivers
SO RIVER RESEARCH AND APPLICATIONS
LA English
DT Article
DE drawdown; navigation pool; restoration; upper Mississippi River; water
level management
ID WATER-LEVEL MANAGEMENT; VEGETATION; EXPOSURE
AB The Upper Mississippi River (UMR) has been developed and subsequently managed for commercial navigation by the U.S. Army Corps of Engineers (USACE). The navigation pools created by a series of lock and dams initially provided a complex of aquatic habitats that supported a variety of fish and wildlife. However, biological productivity declined as the pools aged. The River Resources Forum, an advisory body to the St. Paul District of the USACE, established a multiagency Water Level Management Task Force (WLMTF) to evaluate the potential of water level management to improve ecological function and restore the distribution and abundance of fish and wildlife habitat. The WLMTF identified several water level management options and concluded that summer growing season drawdowns at the pool scale offered the greatest potential to provide habitat benefits over a large area. Here we summarize the process followed to plan and implement pool-wide drawdowns on the UMR, including involvement of stakeholders in decision making, addressing requirements to modify reservoir operating plans, development and evaluation of drawdown alternatives, pool selection, establishment of a monitoring plan, interagency coordination, and a public information campaign. Three pool-wide drawdowns were implemented within the St. Paul District and deemed successful in providing ecological benefits without adversely affecting commercial navigation and recreational use of the pools. Insights are provided based on more than 17years of experience in planning and implementing drawdowns on the UMR. Copyright (c) 2015 John Wiley & Sons, Ltd.
C1 [Kenow, K. P.; Newton, T. J.] US Geol Survey, Upper Midwest Environm Sci Ctr, La Crosse, WI 54603 USA.
[Benjamin, G. L.; Nissen, R. A.] Nature Conservancy, Great Rivers Partnership, La Crosse, WI 54601 USA.
[Schlagenhaft, T. W.] Minnesota Dept Nat Resources, Lake City, MN 55041 USA.
[Jutila, S. A.] US Army Corps Engineers, St Paul, MN 55101 USA.
[Stefanski, M.] US Fish & Wildlife Serv, Upper Mississippi River Natl Wildlife & Fish Refu, Winona, MN 55987 USA.
[Wege, G. J.] US Fish & Wildlife Serv, Ecol Serv Field Off, Bloomington, MN 55437 USA.
[Benjamin, G. L.] Wisconsin Dept Nat Resources, La Crosse, WI 54601 USA.
[Schlagenhaft, T. W.] Audubon, Red Wing, MN 55066 USA.
RP Kenow, KP (reprint author), USGS, Upper Midwest Environm Sci Ctr, 2630 Fanta Reed Rd, La Crosse, WI 54603 USA.
EM kkenow@usgs.gov
OI Kenow, Kevin/0000-0002-3062-5197; Newton, Teresa/0000-0001-9351-5852
NR 31
TC 3
Z9 3
U1 5
U2 11
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1535-1459
EI 1535-1467
J9 RIVER RES APPL
JI River Res. Appl.
PD MAR
PY 2016
VL 32
IS 3
BP 295
EP 308
DI 10.1002/rra.2857
PG 14
WC Environmental Sciences; Water Resources
SC Environmental Sciences & Ecology; Water Resources
GA DG8SU
UT WOS:000372354700007
ER
PT J
AU Brusnahan, JS
Poret, JC
Moretti, JD
Shaw, AP
Sadangi, RK
AF Brusnahan, Jason S.
Poret, Jay C.
Moretti, Jared D.
Shaw, Anthony P.
Sadangi, Rajendra K.
TI Use of Magnesium Diboride as a "Green" Fuel for Green Illuminants
SO ACS SUSTAINABLE CHEMISTRY & ENGINEERING
LA English
DT Article
DE Sustainable pyrotechnics; Illuminants; Fireworks; Magnesium diboride;
Barium-free
ID BORON-CARBIDE; PYROTECHNIC FORMULATIONS; LIGHT ILLUMINANTS; BARIUM; MGB2
AB We report here on the use of magnesium diboride (MgB2) as a barium-free alternative for the pyrotechnic generation of green light. Formulations employing KNO3 as the oxidizer, MgB2 as the fuel, and various binders and additives were investigated. Upon combustion, the compositions were found to generate the photochemically active BO2 radical, which emits green light. Fixing the MgB2 content at 21 wt % gave the closest dominant wavelength (561.4 nm) to that desired for green illuminants and a spectral purity of 33%. The addition of burning rate modifiers to this system was found to inhibit the formation of the BO2 radical. Exchanging the KNO3 oxidizer for NH4ClO4 increased the spectral purity to 45%. Correlations between the results of thermodynamic modeling and the experimental data are also reported.
C1 [Brusnahan, Jason S.] Def Sci & Technol Grp, Edinburgh, SA 5111, Australia.
[Poret, Jay C.; Moretti, Jared D.; Shaw, Anthony P.; Sadangi, Rajendra K.] US Army RDECOM ARDEC, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07806 USA.
RP Brusnahan, JS (reprint author), Def Sci & Technol Grp, Edinburgh, SA 5111, Australia.; Moretti, JD (reprint author), US Army RDECOM ARDEC, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07806 USA.
EM jason.brusnahan@defence.gov.au; jared.d.moretti.civ@mail.mil
FU U.S. Army, RDECOM, ARDEC; Defence Science and Technology Group
FX Eric Latalladi and Fred Moser are thanked for weighing starting
materials and mixing and preparation of the pellets. The U.S. Army,
RDECOM, ARDEC is thanked for funding this work. Jason Brusnahan thanks
the Defence Science and Technology Group for funding his International
Fellowship at Picatinny Arsenal, NJ, U.S.A.
NR 35
TC 0
Z9 0
U1 6
U2 7
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 2168-0485
J9 ACS SUSTAIN CHEM ENG
JI ACS Sustain. Chem. Eng.
PD MAR
PY 2016
VL 4
IS 3
BP 1827
EP 1833
DI 10.1021/acssuschemeng.6b00041
PG 7
WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY;
Engineering, Chemical
SC Chemistry; Science & Technology - Other Topics; Engineering
GA DG0LD
UT WOS:000371755400141
ER
PT J
AU Rose, LF
Chan, RK
AF Rose, Lloyd F.
Chan, Rodney K.
TI The Burn Wound Microenvironment
SO ADVANCES IN WOUND CARE
LA English
DT Review
ID GROWTH-FACTOR-BETA; ORGAN DYSFUNCTION SYNDROME; SOLID LIPID
NANOPARTICLES; THERMAL-INJURY; STEM-CELLS; INFLAMMATORY RESPONSES;
POSTBURN PATIENTS; SKIN SUBSTITUTES; CUTANEOUS WOUNDS; CRITICAL ILLNESS
AB Significance: While the survival rate of the severely burned patient has improved significantly, relatively little progress has been made in treatment or prevention of burn-induced long-term sequelae, such as contraction and fibrosis.
Recent Advances: Our knowledge of the molecular pathways involved in burn wounds has increased dramatically, and technological advances now allow large-scale genomic studies, providing a global view of wound healing processes.
Critical Issues: Translating findings from a large number of in vitro and preclinical animal studies into clinical practice represents a gap in our understanding, and the failures of a number of clinical trials suggest that targeting single pathways or cytokines may not be the best approach. Significant opportunities for improvement exist.
Future Directions: Study of the underlying molecular influences of burn wound healing progression will undoubtedly continue as an active research focus. Increasing our knowledge of these processes will identify additional therapeutic targets, supporting informed clinical studies that translate into clinical relevance and practice.
C1 [Rose, Lloyd F.; Chan, Rodney K.] US Army, Inst Surg Res, Brook Army Med Ctr, Ft Sam Houston, TX 78234 USA.
RP Chan, RK (reprint author), US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
EM rodney.k.chan.ctr@mail.mil
NR 123
TC 0
Z9 0
U1 5
U2 9
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD MAR 1
PY 2016
VL 5
IS 3
BP 106
EP 118
DI 10.1089/wound.2014.0536
PG 13
WC Dermatology
SC Dermatology
GA DF4QK
UT WOS:000371334400003
PM 26989577
ER
PT J
AU Heavens, KR
Charkoudian, N
O'Brien, C
Kenefick, RW
Cheuvront, SN
AF Heavens, Kristen R.
Charkoudian, Nisha
O'Brien, Catherine
Kenefick, Robert W.
Cheuvront, Samuel N.
TI Noninvasive assessment of extracellular and intracellular dehydration in
healthy humans using the resistance-reactance-score graph method
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE volume depletion; hydration assessment; BIVA; hypohydration; hypovolemia
ID BODY-WATER COMPARTMENTS; BIOELECTRICAL-IMPEDANCE; BIOIMPEDANCE
SPECTROSCOPY; DIAGNOSTIC-ACCURACY; MARKERS; STRESS; PLASMA; VOLUME;
BLOOD; MEN
AB Background: Few dehydration assessment measures provide accurate information; most are based on reference change values and very few are diagnostically accurate from a single observation or measure. Bioelectrical impedance may lack the precision to detect common forms of dehydration in healthy individuals. Limitations in bioimpedance may be addressed by a unique resistance reactance (RXc)-score graph method, which transforms vector components into z scores for use with any impedance analyzer in any population.
Objective: We tested whether the RXc-score graph method provides accurate single or serial assessments of dehydration when compared with gold-standard measures of total body water by using stable isotope dilution (deuterium oxide) combined with body weight changes.
Design: We retrospectively analyzed data from a previous study in which 9 healthy young men participated in 3 trials: euhydration (EUH), extracellular dehydration (ED; via a diuretic), and intracellular dehydration (ID; via exercise in the heat).
Results: Participants lost 4-5% of their body weight during the dehydration trials; volume loss was similar between trials (ID compared with ED group: 3.5 +/- 0.8 compared with 3.0 +/- 0.6 L; P > 0.05). Despite significant losses of body water, most RXc vector scores for ED and ID groups were classified as "normal" (within the 75% population tolerance ellipse). However, directional displacement of vectors was consistent with loss of volume in both ED and ID conditions compared with the EUH condition and tended to be longer in ED than in ID conditions (P = 0.054).
Conclusions: We conclude that, whereas individual RXc-score graph values do not provide accurate detection of dehydration from single measurements, directional changes in vector values from serial measurements are consistent with fluid loss for both ED and ID conditions. The RXc-score graph method may therefore alert clinicians to changes in hydration state, which may bolster the interpretation of other recognized change measures of hydration.
C1 [Heavens, Kristen R.; Charkoudian, Nisha; O'Brien, Catherine; Kenefick, Robert W.; Cheuvront, Samuel N.] US Army, Environm Med Res Inst, Natick, MA 01760 USA.
RP Cheuvront, SN (reprint author), US Army, Environm Med Res Inst, Natick, MA 01760 USA.
EM samuel.n.cheuvront.civ@mail.mil
FU US Army Medical Research and Materiel Command
FX Supported by the US Army Medical Research and Materiel Command.
NR 28
TC 0
Z9 0
U1 2
U2 2
PU AMER SOC NUTRITION-ASN
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD MAR
PY 2016
VL 103
IS 3
BP 724
EP 729
DI 10.3945/ajcn.115.115352
PG 6
WC Nutrition & Dietetics
SC Nutrition & Dietetics
GA DF8ZO
UT WOS:000371650200008
PM 26843158
ER
PT J
AU DiStefano, LJ
Marshall, SW
Padua, DA
Peck, KY
Beutler, AI
de la Motte, SJ
Frank, BS
Martinez, JC
Cameron, KL
AF DiStefano, Lindsay J.
Marshall, Stephen W.
Padua, Darin A.
Peck, Karen Y.
Beutler, Anthony I.
de la Motte, Sarah J.
Frank, Barnett S.
Martinez, Jessica C.
Cameron, Kenneth L.
TI The Effects of an Injury Prevention Program on Landing Biomechanics Over
Time
SO AMERICAN JOURNAL OF SPORTS MEDICINE
LA English
DT Article
DE biomechanics; neuromuscular training; military
ID RANDOMIZED-CONTROLLED-TRIAL; CRUCIATE LIGAMENT INJURY; LOWER-EXTREMITY
INJURY; ERROR SCORING SYSTEM; JUMP-ACL; SOCCER PLAYERS; FEMALE SOCCER;
BALANCE; DESIGN; TOOL
AB Background: Knowledge is limited regarding how long improvements in biomechanics remain after completion of a lower extremity injury prevention program.
Purpose: To evaluate the effects of an injury prevention program on movement technique and peak vertical ground-reaction forces (VGRF) over time compared with a standard warm-up (SWU) program.
Study Design: Controlled laboratory study.
Methods: A total of 1104 incoming freshmen (age range, 17-22 years) at a military academy in the United States volunteered to participate. Participants were cluster-randomized by military company to either the Dynamic Integrated Movement Enhancement (DIME) injury prevention program or SWU. A random subsample of participants completed a standardized jump-landing task at each time point: immediately before the intervention (PRE), immediately after (POST), and 2 (POST2M), 4 (POST4M), 6 (POST6M), and 8 months (POST8M) after the intervention. VGRF data collected during the jump-landing task were normalized to body weight (%BW). The Landing Error Scoring System (LESS) was used to evaluate movement technique during the jump landing. The change scores () for each variable (LESS, VGRF) between the group's average value at PRE and each time point were calculated. Separate univariate analyses of variance were performed to evaluate group differences.
Results: The results showed a greater decrease in mean (SD) VGRF in the DIME group compared with the SWU group at all retention time points: POST2M (SWU [(%BW)], -0.13 0.82; DIME, -0.62 +/- 0.91; P = .001), POST4M (SWU, -0.15 +/- 0.98; DIME,-0.46 +/- 0.64; P = .04), POST6M (SWU, -0.04 +/- 0.96; DIME, -0.53 +/- 0.83; P = .004), and POST8M (SWU, 0.38 +/- 0.95; DIME, -0.11 +/- 0.98; P = .003), but there was not a significant improvement in the DIME group between PRE and POST8M ((%BW), -0.11 +/- 0.98). No group differences in LESS were observed.
Conclusion: The study findings demonstrated that an injury prevention program performed as a warm-up can reduce vertical ground-reaction forces compared with a standard warm-up but a maintenance program is likely necessary in order for continued benefit.
Clinical Relevance: Injury prevention programs may need to be performed constantly, or at least every sport season, in order for participants to maintain the protective effects against injury.
C1 [DiStefano, Lindsay J.; Marshall, Stephen W.; Padua, Darin A.; Peck, Karen Y.; Beutler, Anthony I.; de la Motte, Sarah J.; Frank, Barnett S.; Martinez, Jessica C.; Cameron, Kenneth L.] US Mil Acad, West Point, NY 10996 USA.
[DiStefano, Lindsay J.; Martinez, Jessica C.] Univ Connecticut, Dept Kinesiol, Storrs, CT USA.
[Marshall, Stephen W.] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA.
[Padua, Darin A.; Frank, Barnett S.] Univ N Carolina, Dept Exercise & Sport Sci, Chapel Hill, NC USA.
[Peck, Karen Y.; Cameron, Kenneth L.] Keller Army Community Hosp, John Feagin Sports Med Fellowship, West Point, NY USA.
[Beutler, Anthony I.; de la Motte, Sarah J.] Uniformed Serv Univ Hlth Sci, Dept Family Med, Bethesda, MD 20814 USA.
RP DiStefano, LJ (reprint author), Univ Connecticut, Dept Kinesiol, Storrs, CT USA.
EM lindsay.distefano@uconn.edu
OI Cameron, Kenneth/0000-0002-6276-4482
FU United States Military Academy Department of Physical Education
FX The authors acknowledge the United States Military Academy Department of
Physical Education for supporting this project. They also acknowledge
COL Greg Daniels, Dr Jeffrey Coelho, Kristen Koltun, Stephanie DeNicolo,
Hayley Root, Timothy Mauntel, and Molly Grasso, and all the other
invaluable research assistants for their help on this project.
NR 28
TC 0
Z9 0
U1 2
U2 13
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0363-5465
EI 1552-3365
J9 AM J SPORT MED
JI Am. J. Sports Med.
PD MAR
PY 2016
VL 44
IS 3
BP 767
EP 776
DI 10.1177/0363546515621270
PG 10
WC Orthopedics; Sport Sciences
SC Orthopedics; Sport Sciences
GA DF9CQ
UT WOS:000371658300033
PM 26792707
ER
PT J
AU Joyner, MJ
Wallin, BG
Charkoudian, N
AF Joyner, Michael J.
Wallin, B. Gunnar
Charkoudian, Nisha
TI Sex differences and blood pressure regulation in humans
SO EXPERIMENTAL PHYSIOLOGY
LA English
DT Article; Proceedings Paper
CT Experimental Biology Meeting 2015
CY MAR 28-APR 01, 2015
CL Boston, MA
SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut
ID SYMPATHETIC-NERVE ACTIVITY; YOUNG-WOMEN; ORAL-CONTRACEPTIVES; BAROREFLEX
SENSITIVITY; HEMODYNAMIC BALANCE; AUTONOMIC SUPPORT; NEURAL-CONTROL;
OVARIAN CYCLE; HEALTHY WOMEN; MEN
AB New Findings
What is the topic of this review? Over the past decade, our team has investigated interindividual variability in human blood pressure regulation.
What advances does it highlight? In men, we have found a tight relationship between indices of sympathetic activity and vascular resistance across the age span. This relationship is absent in young women but seen in postmenopausal women. These sex and age differences in vascular resistance are largely a result of changes in the balance of vasodilating and vasoconstricting adrenergic receptor tone. When these changes are considered along with cardiac output, a coherent picture is beginning to emerge of why blood pressure rises more with age in women than men.
Arterial pressure is a key regulated variable in the cardiovascular system with important health implications. Over the last 12years, we have used physiological measurements, including muscle sympathetic nerve activity (MSNA), to explore the balance among mean arterial blood pressure, cardiac output and total peripheral resistance (TPR) in normotensive humans. We have shown that these determinants of blood pressure can vary widely in different subjects and how they vary depends on sex and age. In young men, there is a direct relationship between MSNA and TPR but no relationship with blood pressure. This is because cardiac output is proportionally lower in those with high MSNA and TPR. In contrast, in young women there is no relationship between MSNA and TPR (or cardiac output); this is because -adrenergic vasodilator mechanisms offset -adrenergic vasoconstriction. Thus, blood pressure is unrelated to MSNA in young women. In older women, -adrenergic vasodilator mechanisms are diminished, and a direct relationship between MSNA and TPR is seen. In older men, the relationships among these variables are less clear cut, perhaps owing to age-related alterations in endothelial function. With ageing, the relationship between MSNA and blood pressure becomes positive, more so in women than in men. The finding that the physiological control of blood pressure is so different in men and women and that it varies with age suggests that future studies of mechanisms of hypertension will reveal corresponding differences among groups.
C1 [Joyner, Michael J.] Mayo Clin, Dept Anesthesiol, 200 First St SW, Rochester, MN 55905 USA.
[Wallin, B. Gunnar] Gothenburg Univ, Sahlgren Acad Gothenburg, Inst Neurosci & Physiol, Gothenburg, Sweden.
[Charkoudian, Nisha] US Army, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA.
RP Joyner, MJ (reprint author), Mayo Clin, Dept Anesthesiol, 200 First St SW, Rochester, MN 55905 USA.
EM joyner.michael@mayo.edu
FU NIH [HL83947, UL1RR024150]; Caywood professorship
FX The collaborative studies of the authors on these topics were supported
by NIH HL83947, NIH UL1RR024150 and the Caywood professorship.
NR 30
TC 11
Z9 11
U1 4
U2 15
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0958-0670
EI 1469-445X
J9 EXP PHYSIOL
JI Exp. Physiol.
PD MAR 1
PY 2016
VL 101
IS 3
BP 349
EP 355
DI 10.1113/EP085146
PG 7
WC Physiology
SC Physiology
GA DF7IL
UT WOS:000371531200003
PM 26152788
ER
PT J
AU Jarrett, JB
Lounsbery, JL
D'Amico, F
Dickerson, LM
Franko, J
Nagle, J
Seehusen, DA
Wilson, SA
AF Jarrett, Jennie B.
Lounsbery, Jody L.
D'Amico, Frank
Dickerson, Lori M.
Franko, John
Nagle, John
Seehusen, Dean A.
Wilson, Stephen A.
TI Clinical Pharmacists as Educators in Family Medicine Residency Programs:
A CERA Study of Program Directors
SO FAMILY MEDICINE
LA English
DT Article
ID BOARD CERTIFICATION; ECONOMIC OUTCOMES; TRAINING-PROGRAM; SERVICES;
MANAGEMENT; CARE; RECOMMENDATIONS; PRACTITIONERS; SPECIALISTS;
EXPERIENCE
AB BACKGROUND AND OBJECTIVES: The clinical pharmacist's role within family medicine residency programs (FMRPs) is well established. However, there is limited information regarding perceptions of program directors (PDs) about clinical pharmacy educators. The study objectives were (1) to estimate the prevalence of clinical pharmacists within FMRPs and (2) to determine barriers and motivations for incorporation of clinical pharmacists as educators.
METHODS: The Council of Academic Family Medicine Educational Research Alliance (CERA) distributed an electronic survey to PDs. Questions addressed formalized pharmacotherapy education, clinical pharmacists in educator roles, and barriers and benefits of clinical pharmacists in FMRPs.
RESULTS: The overall response rate was 50% (224/451). Seventy-six percent (170/224) of the responding PDs reported that clinical pharmacists provide pharmacotherapy education in their FMRPs, and 57% (97/170) consider clinical pharmacists as faculty members. In programs with clinical pharmacists, 72% (83/116) of PDs reported having a systematic approach for teaching pharmacotherapy versus 22% (21/95) in programs without. In programs without clinical pharmacists, the top barrier to incorporation was limited ability to bill for clinical services 48% (43/89) versus 29% (32/112) in programs with clinical pharmacists. In both programs with and without clinical pharmacists, the top benefit of having clinical pharmacists was providing a collaborative approach to pharmacotherapy education for residents (35% and 36%, respectively).
CONCLUSIONS: Less than half of FMRPs incorporate clinical pharmacists as faculty members. Despite providing collaborative approaches to pharmacotherapy education, their limited ability to bill for services is a major barrier.
C1 [Jarrett, Jennie B.; D'Amico, Frank; Wilson, Stephen A.] Univ Pittsburgh, Med Ctr, St Margaret Family Med Residency Program, Pittsburgh, PA 15260 USA.
[Lounsbery, Jody L.] Univ Minnesota, Coll Pharm, Dept Pharmaceut Care & Hlth Syst, Minneapolis, MN 55455 USA.
[Lounsbery, Jody L.] Univ Minnesota, Sch Med, Dept Family Med & Community Hlth, Minneapolis, MN 55455 USA.
[Wilson, Stephen A.] Univ Pittsburgh, Dept Family Med, Pittsburgh, PA 15260 USA.
[Dickerson, Lori M.] Med Univ S Carolina, Dept Family Med, Charleston, SC USA.
[Franko, John] E Tennessee State Univ, Dept Family Med, Johnson City, TN 37614 USA.
[Nagle, John] Univ Colorado Family Med Residency, Denver, CO USA.
[Seehusen, Dean A.] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA USA.
RP Lounsbery, JL (reprint author), Univ Minnesota, Coll Pharm, 308 Harvard St SE,Room 5-110 WDH, Minneapolis, MN 55455 USA.
EM loun0015@umn.edu
NR 28
TC 3
Z9 3
U1 3
U2 6
PU SOC TEACHERS FAMILY MEDICINE
PI LEAWOOD
PA 11400 TOMAHAWK CREEK PARKWAY, STE 540, LEAWOOD, KS 66207 USA
SN 0742-3225
EI 1938-3800
J9 FAM MED
JI Fam. Med.
PD MAR
PY 2016
VL 48
IS 3
BP 180
EP 186
PG 7
WC Primary Health Care; Medicine, General & Internal
SC General & Internal Medicine
GA DG2QY
UT WOS:000371913900003
PM 26950906
ER
PT J
AU Lee, AG
Tarver, WJ
Mader, TH
Gibson, CR
Hart, SF
Otto, CA
AF Lee, Andrew G.
Tarver, William J.
Mader, Thomas H.
Gibson, Charles Robert
Hart, Stephen F.
Otto, Christian A.
TI Neuro-Ophthalmology of Space Flight
SO JOURNAL OF NEURO-OPHTHALMOLOGY
LA English
DT Review
ID HEAD-DOWN TILT; IDIOPATHIC INTRACRANIAL HYPERTENSION;
CEREBROSPINAL-FLUID OUTFLOW; COTTON-WOOL SPOTS; OPTIC DISC EDEMA;
CHOROIDAL FOLDS; ACQUIRED HYPEROPIA; INTRAOCULAR-PRESSURE; REFRACTIVE
CHANGES; RADIAL KERATOTOMY
AB Background:To describe the history, clinical findings, and possible pathogenic etiologies of the constellation of neuro-ophthalmic findings discovered in astronauts after long-duration space flight and to discuss the terrestrial implications of such findings.Evidence Acquisition:Retrospective review of published observational, longitudinal examination of neuro-ophthalmic findings in astronauts after long-duration space flight; analysis of postflight questionnaires regarding in-flight vision changes in approximately 300 additional astronauts; and hypothesis generating for developing possible future countermeasures and potential implications for neuro-ophthalmic disorders on Earth. Astronauts with neuro-ophthalmic findings, which were not present at the start of a space flight mission and only seen on return from long-duration space missions to the International Space Station, will be discussed.Results:After 6 months of space flight, 7 astronauts had ophthalmic findings consisting of optic disc edema in 5, globe flattening in 5, choroidal folds in 5, cotton-wool spots in 3, nerve fiber layer thickening detected by optical coherence tomography in 6, and decreased near vision in 6. Five of 7 astronauts with near vision complaints had a hyperopic shift +0.50 diopters (D) between pre-/post-mission spherical equivalent refraction in 1 or both eyes (range, +0.50 to +1.75 D). These 5 astronauts showed globe flattening on magnetic resonance imaging. A total of 6 lumbar punctures have been performed to date (4 in the originally described cohort) and documented opening pressures of 18, 22, 21, 21.5, 28, and 28.5 cm H2O. These were performed at 8, 66, 19, 7, 12, and 57 days after mission, respectively. The 300 postflight questionnaires documented that approximately 29% and 60% of astronauts on short-duration and long-duration missions, respectively, experienced a degradation in distant and near visual acuity. Some of these vision changes remain unresolved for years after flight. Several possible pathogenic mechanisms, as well as potential countermeasures and discussion of possible terrestrial implications, are described.Conclusions:We previously hypothesized that the optic nerve and ocular changes that we described in astronauts may be the result of orbital and cranial cephalad fluid shifts brought about by prolonged microgravity exposure. The findings we reported previously and continue to see in astronauts may represent parts of a spectrum of ocular and cerebral responses to extended microgravity exposure. Future investigations hopefully will lead to countermeasures that can be used to eliminate or lessen the magnitude of these potentially harmful findings before long-duration space flight including the possibility of a manned mission to Mars.
C1 [Lee, Andrew G.; Gibson, Charles Robert] Houston Methodist Hosp, Dept Ophthalmol, Houston, TX 77030 USA.
[Lee, Andrew G.] Baylor Coll Med, Dept Ophthalmol, Houston, TX 77030 USA.
[Lee, Andrew G.] Weill Cornell Med Coll, Dept Ophthalmol, New York, NY USA.
[Lee, Andrew G.] Weill Cornell Med Coll, Dept Neurol, New York, NY USA.
[Lee, Andrew G.] Weill Cornell Med Coll, Dept Neurosurg, New York, NY USA.
[Lee, Andrew G.] Univ Texas Med Branch, Dept Ophthalmol, Galveston, TX 77555 USA.
[Lee, Andrew G.] Univ Iowa Hosp & Clin, Dept Ophthalmol, Iowa City, IA 52242 USA.
[Lee, Andrew G.] Univ Texas MD Anderson Canc Ctr, Sect Ophthalmol, Houston, TX 77030 USA.
[Tarver, William J.; Hart, Stephen F.] NASA, Space Med Div, Washington, DC 20546 USA.
[Mader, Thomas H.] US Army, Cooper Landing, AK USA.
[Gibson, Charles Robert] Coastal Eye Associates, Webster, TX USA.
[Otto, Christian A.] Univ Space Res Assoc, NASA, Washington, DC USA.
RP Lee, AG (reprint author), Houston Methodist Hosp, Blanton Eye Inst, Dept Ophthalmol, 6560 Fannin St,Scurlock 450, Houston, TX 77030 USA.
EM aglee@houstonmethodist.org
NR 60
TC 2
Z9 2
U1 2
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1070-8022
EI 1536-5166
J9 J NEURO-OPHTHALMOL
JI J. Neuro-Ophthal.
PD MAR
PY 2016
VL 36
IS 1
BP 85
EP 91
DI 10.1097/WNO.0000000000000334
PG 7
WC Clinical Neurology; Ophthalmology
SC Neurosciences & Neurology; Ophthalmology
GA DF7JM
UT WOS:000371534000020
PM 26828842
ER
PT J
AU Mader, TH
Gibson, CR
Hart, SF
Lee, AG
AF Mader, Thomas H.
Gibson, C. Robert
Hart, Stephen F.
Lee, Andrew G.
TI Asymmetric Papilledema in Idiopathic Intracranial Hypertension: Comment
SO JOURNAL OF NEURO-OPHTHALMOLOGY
LA English
DT Letter
ID DURATION SPACE-FLIGHT; OPTIC DISC EDEMA; ASTRONAUT
C1 [Mader, Thomas H.] US Army, Moab, UT USA.
[Gibson, C. Robert] Coastal Eye Associates, Webster, TX USA.
[Hart, Stephen F.] NASA, Div Life Sci, Houston, TX USA.
[Lee, Andrew G.] Methodist Hosp, Dept Ophthalmol, 6535 Fannin, Houston, TX 77030 USA.
RP Mader, TH (reprint author), US Army, Moab, UT USA.
NR 5
TC 0
Z9 0
U1 2
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1070-8022
EI 1536-5166
J9 J NEURO-OPHTHALMOL
JI J. Neuro-Ophthal.
PD MAR
PY 2016
VL 36
IS 1
BP 111
EP 112
PG 2
WC Clinical Neurology; Ophthalmology
SC Neurosciences & Neurology; Ophthalmology
GA DF7JM
UT WOS:000371534000024
PM 26885711
ER
PT J
AU Horsmon, MS
Vincelli, NM
Taylor, JT
Kristovich, RL
AF Horsmon, Michael S.
Vincelli, Nicole M.
Taylor, James T.
Kristovich, Robert L.
TI An Impedance-Based Model for the Assessment of Cardiopulmonary Function
in Rabbits
SO JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE
LA English
DT Article
ID PNEUMOGRAPH
AB Improving the quality of physiologic data collected from research animals is most easily accomplished by collecting as much information as possible from a single subject, thereby reducing animal use and error associated with satellite groups. We investigated the feasibility of using a large-animal implantable telemetry device in New Zealand white rabbits (n = 6). The first task was to develop an implantation technique that yielded calibrated tidal volume (Vt) measurements that were within 10% of those obtained simultaneously from a pneumotachograph, a low-noise electrocardiogram, and stable blood pressure. The second task was to challenge implanted rabbits with the respiratory stimulant doxapram to assess linearity of the calibration across a range of Vt. Of the 3 electrode placements attempted, only one resulted in calibrations consistently below 10% error. Optimal electrode placement resulted in calibrated Vt measurements within 1.7% +/- 0.3% of those obtained from a pneumotachograph during normal tidal breathing, 7.3% +/- 0.7% of those after saline injection, and 6.0% +/- 0.5% of those after doxapram injection. The Vt range was 9 to 15 mL for normal tidal breathing and saline injection and 25 to 30 mL after doxapram injection. Increases in mean arterial pressure of 25.0 +/- 6.82 mm Hg and decreases in heart rate of 56.3 +/- 6.82 bpm were associated with doxapram injection only. Our findings represent the first time that multiple cardiopulmonary endpoints have been assessed by telemetry in conscious, restrained rabbits. Whether animal position affects calibration accuracy warrants investigation.
C1 [Horsmon, Michael S.; Kristovich, Robert L.] US Army, Edgewood Chem Biol Ctr, Gunpowder, MD USA.
[Vincelli, Nicole M.; Taylor, James T.] Leidos, Gunpowder, MD USA.
RP Horsmon, MS (reprint author), US Army, Edgewood Chem Biol Ctr, Gunpowder, MD USA.
EM michael.s.horsmon.civ@mail.mil
FU Defense Threat Reduction Agency
FX This study was funded by the Defense Threat Reduction Agency; the agency
did not play any role in the study design, collection, analysis, and
interpretation of the data, or writing of this report. The decision to
publish this report is authorized by the agency.
NR 13
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC LABORATORY ANIMAL SCIENCE
PI MEMPHIS
PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA
SN 1559-6109
J9 J AM ASSOC LAB ANIM
JI J. Amer. Assoc. Lab. Anim. Sci.
PD MAR
PY 2016
VL 55
IS 2
BP 213
EP 220
PG 8
WC Veterinary Sciences; Zoology
SC Veterinary Sciences; Zoology
GA DG1SR
UT WOS:000371848300013
PM 27025814
ER
PT J
AU Yuffa, AJ
Gutierrez, Y
Sanz, JM
de la Osa, RA
Saiz, JM
Gonzalez, F
Moreno, F
Videen, G
AF Yuffa, Alex J.
Gutierrez, Yael
Sanz, Juan M.
Alcaraz de la Osa, Rodrigo
Saiz, Jose M.
Gonzalez, Francisco
Moreno, Fernando
Videen, Gorden
TI Near- and far-field scattering resonance frequency shift in dielectric
and perfect electric conducting cylinders
SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND
VISION
LA English
DT Article
ID SURFACE; PARTICLES
AB The ability to infer near-field scattering properties from far-field measurements is of paramount importance in nano-optics. Recently we derived an approximate formula for predicting the frequency shift between near-and far-field intensity peaks in the case of a dielectric sphere. In this work we demonstrate that almost an identical formula can be used to predict the resonance shift of a dielectric cylinder and a perfectly conducting cylinder. We find the redshift of the resonance peak of the perfect electric conducting cylinder to be approximately 2 orders of magnitude greater than for the dielectric cylinder. The errors in our approximate analytic formula for predicting the redshift are approximately only twice as great. Furthermore, we apply the redshift formula to a silicon cylinder and discuss its magneto-dielectric properties, which may be of interest in design of metamaterials. (C) 2016 Optical Society of America
C1 [Yuffa, Alex J.; Videen, Gorden] Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
[Gutierrez, Yael; Sanz, Juan M.; Alcaraz de la Osa, Rodrigo; Saiz, Jose M.; Gonzalez, Francisco; Moreno, Fernando; Videen, Gorden] Univ Cantabria, Dept Fis Aplicada, Fac Ciencias, Grp Opt, Avda Los Castros S-N, E-39005 Santander, Spain.
RP Yuffa, AJ (reprint author), Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM ayuffa@gmail.com
RI Yuffa, Alex/B-5498-2014
OI Yuffa, Alex/0000-0002-3600-1131
NR 20
TC 0
Z9 0
U1 0
U2 2
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 1084-7529
EI 1520-8532
J9 J OPT SOC AM A
JI J. Opt. Soc. Am. A-Opt. Image Sci. Vis.
PD MAR 1
PY 2016
VL 33
IS 3
BP 391
EP 395
DI 10.1364/JOSAA.33.000391
PG 5
WC Optics
SC Optics
GA DG0UR
UT WOS:000371781700050
PM 26974908
ER
PT J
AU McAnally, WH
Kirby, R
Hodge, SH
Welp, TL
Greiser, N
Shrestha, P
McGowan, D
Turnipseed, P
AF McAnally, W. H.
Kirby, R.
Hodge, S. H.
Welp, T. L.
Greiser, N.
Shrestha, P.
McGowan, D.
Turnipseed, P.
TI Nautical Depth for US Navigable Waterways: A Review
SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING
LA English
DT Review
DE Dredging; Fluid mud; Channels; Ports; Harbors; Nautical depth;
Bathymetric survey; Echo sounder
ID FLUID MUD; NAVIGATION; AREAS; MANAGEMENT; ESTUARIES; LAKES; BAYS
AB The present state of navigation engineering knowledge concerning nautical depth in ports and waterways with fluid mud is summarized to examine the potential for successful application of the nautical depth concept in U.S. navigable waterways. Nautical depth defines a safe and effective channel bottom criterion in areas where fluid mud confounds conventional acoustic (echo sounder) surveying methods. Fluid mud is a high-concentration suspension that typically behaves as a non-Newtonian fluid. It occurs in ports and channels on all U.S. coastlines and accounts for a significant portion of the United States' $1 billion dredging expense. Nautical depth has been adopted in multiple ports on three continents. Where nautical depth application is appropriate, it often reduces dredging frequency and dredged material volume and can provide water quality benefits. Multiple experiments and field experience have shown that vessels can safely transit areas with fluid mud below the keel. The United States' adoption of the nautical depth concept for select ports and waterways can be expected to reduce dredging frequency and volumes. It offers potential economic and environmental benefits but will require a consensus among federal, state, and local organizations with responsibilities for constructing, operating, maintaining, marking, and using navigable waterways.
C1 [McAnally, W. H.] Mississippi State Univ, 2 Res Blvd, Starkville, MS 39762 USA.
[Kirby, R.] Ravensrodd Consultants, 6 Queens Dr, Taunton TA1 4XW, Somerset, England.
[Hodge, S. H.] Attorney Law, 4107 Franklin Ave, Gulfport, MS 39507 USA.
[Welp, T. L.] US Army, COE Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
[Greiser, N.] Emder Grunder Innenzentrum GmbH EGZ, Consultants Sell Greiser GmbH & Co KG, Zum Nordkai 16, D-26725 Emden, Germany.
[Shrestha, P.] Exponent, 320 Goddard 200, Irvine, CA 92618 USA.
[McGowan, D.] Insight, POB 4200, Jackson, MS 39296 USA.
[Turnipseed, P.] US Geol Survey Southeast Reg, 3535 S Sherwood Forest Blvd,Suite 120, Baton Rouge, LA 70816 USA.
RP McAnally, WH (reprint author), Mississippi State Univ, 2 Res Blvd, Starkville, MS 39762 USA.
EM whmcanally@gmail.com
NR 66
TC 1
Z9 1
U1 6
U2 10
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0733-950X
EI 1943-5460
J9 J WATERW PORT COAST
JI J. Waterw. Port Coast. Ocean Eng.
PD MAR
PY 2016
VL 142
IS 2
AR 04015014
DI 10.1061/(ASCE)WW.1943-5460.0000301
PG 13
WC Engineering, Civil; Engineering, Ocean; Water Resources
SC Engineering; Water Resources
GA DF9NF
UT WOS:000371687300001
ER
PT J
AU George, AA
Hargrove, VM
Molina, DK
AF George, Alan A.
Hargrove, Veronica M.
Molina, D. Kimberley
TI Postmortem Propofol Levels A Case of Residual Detection Long After
Administration
SO AMERICAN JOURNAL OF FORENSIC MEDICINE AND PATHOLOGY
LA English
DT Article
DE propofol; residual; Diprivan; forensic pathology; postmortem; detection
ID PHARMACOKINETICS; LETHAL; ABUSE; DEATH; PHARMACODYNAMICS; INTOXICATION;
SEDATION
AB Propofol has gained notoriety in recent years because of its involvement in high-profile deaths and has increasingly become a drug of misuse and abuse particularly by health care personnel with easy access to it. In addition, propofol has also been used for more nefarious purposes such as murder and suicide. These, coupled with the drug's routine use for both major and minor medical procedures, provide ample opportunities for it to be implicated as a cause of death or contributing factor. In such instances, forensic investigators may be faced with the task of not only detecting the presence of propofol on postmortem toxicology screening, but also determining if it was indeed responsible for the decedent's demise. While propofol has a high volume of distribution, it is thought to equilibrate and be eliminated rapidly and not show significant tissue accumulation. However, this article presents a case illustrating that propofol can accumulate in the tissues and may be found up to a week after administration. This capacity to accumulate implies that postmortem detection does not necessarily confirm administration near the time of death, and further investigation needs to be undertaken to determine the timeline of events in order to rule out other factors, such as recent medical interventions, before attributing the cause of death to the presence of the drug.
C1 [George, Alan A.] Brooke Army Med Ctr, Dept Pathol, Ft Sam Houston, TX 78234 USA.
[Hargrove, Veronica M.; Molina, D. Kimberley] Bexar Cty Med Examiners Off, 7337 Louis Pasteur Dr, San Antonio, TX 78229 USA.
RP Molina, DK (reprint author), Bexar Cty Med Examiners Off, 7337 Louis Pasteur Dr, San Antonio, TX 78229 USA.
EM kmolina@bexar.org
NR 20
TC 1
Z9 1
U1 3
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0195-7910
EI 1533-404X
J9 AM J FOREN MED PATH
JI Am. J. Forensic Med. Pathol.
PD MAR
PY 2016
VL 37
IS 1
BP 4
EP 6
DI 10.1097/PAF.0000000000000209
PG 3
WC Medicine, Legal; Pathology
SC Legal Medicine; Pathology
GA DE2WT
UT WOS:000370488800002
PM 26513757
ER
PT J
AU Scaravilli, V
Kreyer, S
Belenkiy, S
Linden, K
Zanella, A
Li, YS
Dubick, MA
Cancio, LC
Pesenti, A
Batchinsky, AI
AF Scaravilli, Vittorio
Kreyer, Stefan
Belenkiy, Slava
Linden, Katharina
Zanella, Alberto
Li, Yansong
Dubick, Michael A.
Cancio, Leopoldo C.
Pesenti, Antonio
Batchinsky, Andriy I.
TI Extracorporeal Carbon Dioxide Removal Enhanced by Lactic Acid Infusion
in Spontaneously Breathing Conscious Sheep
SO ANESTHESIOLOGY
LA English
DT Article
ID POSITIVE-PRESSURE VENTILATION; ACUTE RESPIRATORY-FAILURE; CO2 REMOVAL;
MECHANICAL VENTILATION; GLUCOSE-METABOLISM; CARDIOGENIC-SHOCK;
EXTRACELLULAR PH; LACTATE; INHALATION; MANAGEMENT
AB Background:
The authors studied the effects on membrane lung carbon dioxide extraction (VCO2ML), spontaneous ventilation, and energy expenditure (EE) of an innovative extracorporeal carbon dioxide removal (ECCO2R) technique enhanced by acidification (acid load carbon dioxide removal [ALCO(2)R]) via lactic acid.
Methods:
Six spontaneously breathing healthy ewes were connected to an extracorporeal circuit with blood flow 250 ml/min and gas flow 10 l/min. Sheep underwent two randomly ordered experimental sequences, each consisting of two 12-h alternating phases of ALCO(2)R and ECCO2R. During ALCO(2)R, lactic acid (1.5 mEq/min) was infused before the membrane lung. Caloric intake was not controlled, and animals were freely fed. VCO2ML, natural lung carbon dioxide extraction, total carbon dioxide production, and minute ventilation were recorded. Oxygen consumption and EE were calculated.
Results:
ALCO(2)R enhanced VCO2ML by 48% relative to ECCO2R (55.3 +/- 3.1 vs. 37.2 +/- 3.2 ml/min; P less than 0.001). During ALCO(2)R, minute ventilation and natural lung carbon dioxide extraction were not affected (7.88 +/- 2.00 vs. 7.51 +/- 1.89 l/min, P = 0.146; 167.9 +/- 41.6 vs. 159.6 +/- 51.8 ml/min, P = 0.063), whereas total carbon dioxide production, oxygen consumption, and EE rose by 12% each (223.53 +/- 42.68 vs. 196.64 +/- 50.92 ml/min, 215.3 +/- 96.9 vs. 189.1 +/- 89.0 ml/min, 67.5 +/- 24.0 vs. 60.3 +/- 20.1 kcal/h; P less than 0.001).
Conclusions:
ALCO(2)R was effective in enhancing VCO2ML. However, lactic acid caused a rise in EE that made ALCO(2)R no different from standard ECCO2R with respect to ventilation. The authors suggest coupling lactic acid-enhanced ALCO(2)R with active measures to control metabolism.
C1 [Scaravilli, Vittorio; Zanella, Alberto] Univ Milano Bicocca, Dipartimento Sci Salute, Monza, MB, Italy.
[Scaravilli, Vittorio; Kreyer, Stefan; Belenkiy, Slava; Linden, Katharina; Li, Yansong; Cancio, Leopoldo C.; Batchinsky, Andriy I.] US Army, Inst Surg Res, Comprehens Intens Care Res Task Area, Ft Sam Houston, TX 78234 USA.
[Dubick, Michael A.] US Army, Inst Surg Res, Damage Control Resuscitat Task Area, Ft Sam Houston, TX 78234 USA.
[Scaravilli, Vittorio; Kreyer, Stefan] Natl Acad, Natl Res Council, Washington, DC USA.
[Kreyer, Stefan] Univ Hosp Bonn, Dept Anesthesiol & Intens Care Med, Bonn, Germany.
[Linden, Katharina] Univ Hosp Bonn, Dept Pediat, Bonn, Germany.
[Pesenti, Antonio] Univ Milan, Dipartimento Fisiopatol Med Chirurg & Trapianti, Milan, Italy.
[Pesenti, Antonio] Osped Maggiore Policlin, Fdn IRCCS Ca Granda, Dipartimento Anestesia Rianimaz & Emergenza Urgen, Milan, Italy.
RP Scaravilli, V (reprint author), Univ Milano Bicocca, Dipartimento Sci Salute, Monza, MB, Italy.
EM vittorio.scaravilli@gmail.com
FU U.S. Army through the In-House Laboratory Independent Research Program
at the U.S. Army Institute of Surgical Research, San Antonio, Texas
FX Funding for this study was provided by the U.S. Army through the
In-House Laboratory Independent Research Program at the U.S. Army
Institute of Surgical Research, San Antonio, Texas.
NR 40
TC 1
Z9 1
U1 3
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0003-3022
EI 1528-1175
J9 ANESTHESIOLOGY
JI Anesthesiology
PD MAR
PY 2016
VL 124
IS 3
BP 674
EP 682
DI 10.1097/ALN.0000000000000995
PG 9
WC Anesthesiology
SC Anesthesiology
GA DE5US
UT WOS:000370698900021
PM 26756517
ER
PT J
AU Gazonas, GA
Wildman, RA
Hopkins, DA
Scheidler, MJ
AF Gazonas, George A.
Wildman, Raymond A.
Hopkins, David A.
Scheidler, Michael J.
TI Longitudinal impact of piezoelectric media
SO ARCHIVE OF APPLIED MECHANICS
LA English
DT Article
DE 1-D elastodynamics; Numerical inverse Laplace transform; Mathematica
source code; d ' Alembert method; Dubner-Abate-Crump
ID LAPLACE TRANSFORMS; NUMERICAL INVERSION; WAVES; IMPROVEMENT; TRANSDUCER;
CONSTANTS; QUARTZ; STRAIN
AB We consider the elastodynamic impact problem involving a one-dimensional finite-thickness piezoelectric flyer traveling at initial velocity V-0 that collides with (and adheres to) a stationary piezoelectric target of finite thickness backed by a semi-infinite non-piezoelectric elastic half-space. We derive expressions for the stress, velocity, and electric displacement in the target at all times after impact. A combined d'Alembert and Laplace transform method is used to derive new numerically based solutions for this class of transient wave propagation problems. A modified Dubner-Abate-Crump (DAC) algorithm is used to invert the analytical Laplace transform domain solutions to the time domain. Unlike many authors who neglect electromechanical coupling in the initially unstressed region ahead of the shock, we consider this effect, which gives rise to the development of a tensile stress wave within the piezoelectric target ahead of the shock. To solve the problem, we derive a new piezoelectric impact boundary condition and apply it to the problem of a finite quartz (Si) flyer impacting a lead zirconate titanate (PZT-4) target and find that the solutions obtained using the modified DAC algorithm compare well with those obtained using both a finite-difference time-domain method, and the commercial finite element code, COMSOL multiphysics.
C1 [Gazonas, George A.; Wildman, Raymond A.; Hopkins, David A.; Scheidler, Michael J.] US Army Res Lab, ATTN RDRL WMM B, Aberdeen Proving Ground, MD 21005 USA.
RP Gazonas, GA (reprint author), US Army Res Lab, ATTN RDRL WMM B, Aberdeen Proving Ground, MD 21005 USA.
EM george.a.gazonas.civ@mail.mil; raymond.a.wildman.civ@mail.mil;
david.a.hopkins.civ@mail.mil; michael.j.scheidler2.ctr@mail.mil
OI Gazonas, George/0000-0002-2715-016X
NR 31
TC 0
Z9 0
U1 0
U2 5
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0939-1533
EI 1432-0681
J9 ARCH APPL MECH
JI Arch. Appl. Mech.
PD MAR
PY 2016
VL 86
IS 3
BP 497
EP 515
DI 10.1007/s00419-015-1042-3
PG 19
WC Mechanics
SC Mechanics
GA DF3JN
UT WOS:000371240200007
ER
PT J
AU Marusich, LR
Bakdash, JZ
Onal, E
Yu, MS
Schaffer, J
O'Donovan, J
Hollerer, T
Buchler, N
Gonzalez, C
AF Marusich, Laura R.
Bakdash, Jonathan Z.
Onal, Emrah
Yu, Michael S.
Schaffer, James
O'Donovan, John
Hoellerer, Tobias
Buchler, Norbou
Gonzalez, Cleotilde
TI Effects of Information Availability on Command-and-Control Decision
Making: Performance, Trust, and Situation Awareness
SO HUMAN FACTORS
LA English
DT Article
DE information; situation awareness; trust; decision making; command and
control; network enabled operations
ID COGNITIVE-ABILITIES; DYNAMIC-SYSTEMS; WORKING-MEMORY; TASK;
ENVIRONMENTS; TIME
AB Objective: We investigated how increases in task-relevant information affect human decision-making performance, situation awareness (SA), and trust in a simulated command-and-control (C2) environment.
Background: Increased information is often associated with an improvement of SA and decision-making performance in networked organizations. However, previous research suggests that increasing information without considering the task relevance and the presentation can impair performance.
Method: We used a simulated C2 task across two experiments. Experiment 1 varied the information volume provided to individual participants and measured the speed and accuracy of decision making for task performance. Experiment 2 varied information volume and information reliability provided to two participants acting in different roles and assessed decision-making performance, SA, and trust between the paired participants.
Results: In both experiments, increased task-relevant information volume did not improve task performance. In Experiment 2, increased task-relevant information volume reduced self-reported SA and trust, and incorrect source reliability information led to poorer task performance and SA.
Conclusion: These results indicate that increasing the volume of information, even when it is accurate and task relevant, is not necessarily beneficial to decision-making performance. Moreover, it may even be detrimental to SA and trust among team members.
Application: Given the high volume of available and shared information and the safety-critical and time-sensitive nature of many decisions, these results have implications for training and system design in C2 domains. To avoid decrements to SA, interpersonal trust, and decision-making performance, information presentation within C2 systems must reflect human cognitive processing limits and capabilities.
C1 [Marusich, Laura R.; Bakdash, Jonathan Z.; Buchler, Norbou] US Army Res Lab, Aberdeen Proving Ground, MD USA.
[Onal, Emrah] SA Technol Inc, Marietta, GA USA.
[Yu, Michael S.] Carnegie Mellon Univ, Pittsburgh, PA 15213 USA.
[Schaffer, James] Univ Calif Santa Barbara, Four Eyes Lab, Santa Barbara, CA 93106 USA.
[O'Donovan, John] Univ Calif Santa Barbara, Dept Comp Sci, Santa Barbara, CA 93106 USA.
[Hoellerer, Tobias] Univ Calif Santa Barbara, Comp Sci, Santa Barbara, CA 93106 USA.
[Gonzalez, Cleotilde] Carnegie Mellon Univ, Dynam Decis Making Lab, Pittsburgh, PA 15213 USA.
RP Marusich, LR (reprint author), US Army Res Lab, Bldg 91012 Stn Ave, Ft Hood, TX 76544 USA.
EM laura.r.marusich.ctr@mail.mil
RI Yu, Michael/M-2041-2015
OI Yu, Michael/0000-0002-2445-4555
FU Network Science Collaborative Technology Alliance - U.S. Army Research
Laboratory [W911NF-09-2-0053]
FX This research was supported by the Network Science Collaborative
Technology Alliance sponsored by the U.S. Army Research Laboratory under
Cooperative Agreement No. W911NF-09-2-0053 and by an appointment to the
U.S. Army Research Laboratory Postdoctoral Fellowship Program
administered by the Oak Ridge Associated Universities. The views and
conclusions contained in this document are those of the authors and
should not be interpreted as representing the official policies, either
expressed or implied, of the U.S. Army Research Laboratory or the U.S.
government.
NR 51
TC 3
Z9 3
U1 22
U2 35
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0018-7208
EI 1547-8181
J9 HUM FACTORS
JI Hum. Factors
PD MAR
PY 2016
VL 58
IS 2
BP 301
EP 321
DI 10.1177/0018720815619515
PG 21
WC Behavioral Sciences; Engineering, Industrial; Ergonomics; Psychology,
Applied; Psychology
SC Behavioral Sciences; Engineering; Psychology
GA DF4PJ
UT WOS:000371331400007
PM 26822796
ER
PT J
AU Gehrich, AP
Lustik, MB
Mehr, AA
Patzwald, JR
AF Gehrich, Alan P.
Lustik, Michael B.
Mehr, Allen A.
Patzwald, Jason R.
TI Risk of postoperative urinary tract infections following midurethral
sling operations in women undergoing hysterectomy
SO INTERNATIONAL UROGYNECOLOGY JOURNAL
LA English
DT Article; Proceedings Paper
CT 40th Meeting of the International-Urogynecological-Association
CY JUN 11, 2015
CL Nice, FRANCE
SP Amer Urogynecol Soc
DE Hysterectomy; Midurethral sling; Prolapse operations; TOT; TVT; Urinary
tract infection
ID RANDOMIZED-CONTROLLED-TRIAL; SURGERY; COMPLICATIONS; PROPHYLAXIS
AB Introduction and hypothesis Urinary tract infections (UTIs) are the most common complication following hysterectomy and mid-urethral sling procedures (MUS). As a MUS is often placed at the time of hysterectomy, we sought to determine if the addition of an MUS procedure significantly increases the risk of UTI in the first 30 days following hysterectomy.
Methods This retrospective cohort study utilizes the National Surgical Quality Improvement Program (NSQIP) data bank for the years 2006-2012. The database collects data on all enrolled patients preoperatively and in the first 30 days postoperatively.The database was searched using procedural codes for various types of hysterectomies and MUS procedures. We assessed the incidence of postoperative UTIs following hysterectomy (HYST) only, MUS only, and hysterectomy combined with MUS (HYST+MUS). Adjusted logistic regression analyses were performed to evaluate the effects of individual risk factors and models of interaction.
Results The NSQIP cohort included 3,757 in the HYST+MUS group, 9,851 in the MUS-only group, and 57,398 in the HYST-only group. The rates of postoperative UTI, which was the most common postoperative morbidity, were 5.3, 3.4, and 2.5 % respectively. Multivariate logistic regression analysis showed a persistent significant increase in rates of UTI (p<0.001) between the MUS+HYST group and the HYST-only group. This significance was not maintained between the MUS-only group and the MUS+HYST group.
Conclusions Data from the NSQIP databank indicate that performing an MUS in combination with hysterectomy nearly doubles the risk of postoperative UTI over a hysterectomy alone.
C1 [Gehrich, Alan P.; Mehr, Allen A.; Patzwald, Jason R.] Tripler Army Med Ctr, Dept Obstet & Gynecol, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
[Lustik, Michael B.] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA.
RP Gehrich, AP (reprint author), Tripler Army Med Ctr, Dept Obstet & Gynecol, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM alan.p.gehrich.mil@mail.mil
NR 18
TC 1
Z9 1
U1 0
U2 0
PU SPRINGER LONDON LTD
PI LONDON
PA 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND
SN 0937-3462
EI 1433-3023
J9 INT UROGYNECOL J
JI Int. Urogynecol. J.
PD MAR
PY 2016
VL 27
IS 3
BP 483
EP 490
DI 10.1007/s00192-015-2861-z
PG 8
WC Obstetrics & Gynecology; Urology & Nephrology
SC Obstetrics & Gynecology; Urology & Nephrology
GA DF2OD
UT WOS:000371182300021
PM 26467938
ER
PT J
AU Su, YT
Bethel, J
Hu, SW
AF Su, Yun-Ting
Bethel, James
Hu, Shuowen
TI Octree-based segmentation for terrestrial LiDAR point cloud data in
industrial applications
SO ISPRS JOURNAL OF PHOTOGRAMMETRY AND REMOTE SENSING
LA English
DT Article
DE Terrestrial LiDAR; Point cloud segmentation; Split and merge; Piping
systems; Cylinder detection
ID ALGORITHM; IMAGES
AB Automated and efficient algorithms to perform segmentation of terrestrial LiDAR data is critical for exploitation of 3D point clouds, where the ultimate goal is CAD modeling of the segmented data. In this work, a novel segmentation technique is proposed, starting with octree decomposition to recursively divide the scene into octants or voxels, followed by a novel split and merge framework that uses graph theory and a series of connectivity analyses to intelligently merge components into larger connected components. The connectivity analysis, based on a combination of proximity, orientation, and curvature connectivity criteria, is designed for the segmentation of pipes, vessels, and walls from terrestrial LiDAR data of piping systems at industrial sites, such as oil refineries, chemical plants, and steel mills. The proposed segmentation method is exercised on two terrestrial LiDAR datasets of a steel mill and a chemical plant, demonstrating its ability to correctly reassemble and segregate features of interest. (C) 2016 International Society for Photogrammetry and Remote Sensing, Inc. (ISPRS). Published by Elsevier B.V. All rights reserved.
C1 [Su, Yun-Ting; Bethel, James] Purdue Univ, Sch Civil Engn, Geomat Engn, 550 Stadium Mall Dr, W Lafayette, IN 47907 USA.
[Hu, Shuowen] US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
RP Su, YT (reprint author), Purdue Univ, Sch Civil Engn, Geomat Engn, 550 Stadium Mall Dr, W Lafayette, IN 47907 USA.
EM yunting.su2015@gmail.com
NR 34
TC 1
Z9 1
U1 4
U2 22
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0924-2716
EI 1872-8235
J9 ISPRS J PHOTOGRAMM
JI ISPRS-J. Photogramm. Remote Sens.
PD MAR
PY 2016
VL 113
BP 59
EP 74
DI 10.1016/j.isprsjprs.2016.01.001
PG 16
WC Geography, Physical; Geosciences, Multidisciplinary; Remote Sensing;
Imaging Science & Photographic Technology
SC Physical Geography; Geology; Remote Sensing; Imaging Science &
Photographic Technology
GA DF7RJ
UT WOS:000371555000005
ER
PT J
AU Pushpakaran, BN
Bayne, SB
Ogunniyi, AA
AF Pushpakaran, Bejoy N.
Bayne, Stephen B.
Ogunniyi, Aderinto A.
TI Physics-based simulation of 4H-SIC DMOSFET structure under inductive
switching
SO JOURNAL OF COMPUTATIONAL ELECTRONICS
LA English
DT Article
DE Clamped inductive switching; Electro-thermal simulation; Lattice
heating; Power DMOSFET; Silicon carbide; Silvaco ATLAS TCAD
ID POWER ELECTRONICS; VOLTAGE; DEVICES; DIODES; MOSFET
AB The integration of high power silicon carbide (SiC) Metal Oxide Semiconductor Field Effect Transistors (MOSFETs) in today's power systems drives the demand for deeper understanding of the device switching characteristics by way of device simulation. Applications like motor drive require power MOSFETs to drive highly inductive loads which increase the switching power loss by extending the voltage and current crossover, a situation which gets exacerbated by the presence of parasitic inductance. A 2D model of a 1200 V 4H-SiC vertical DMOSFET half-cell was developed using a commercially available TCAD software package to investigate the electro-thermal switching characteristics using clamped inductive switching circuit for ON state drain current density values up to at an ambient lattice temperature of 300 K. Device physics-based models were included to account for carrier mobility, carrier generation and recombination, impact ionization and lattice heating. In order to analyze the areas of localized lattice heating, the lattice temperature distribution was monitored during simulation. The clamped inductive switching circuit simulations were performed with and without the addition of parasitic electrode inductance to observe the difference in switching energy loss.
C1 [Pushpakaran, Bejoy N.; Bayne, Stephen B.] Texas Tech Univ, Elect & Comp Engn, 2500 Broadway, Lubbock, TX 79409 USA.
[Ogunniyi, Aderinto A.] Army Res Lab, SEDD, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
RP Pushpakaran, BN (reprint author), Texas Tech Univ, Elect & Comp Engn, 2500 Broadway, Lubbock, TX 79409 USA.
EM bejoy.pushpakaran@ttu.edu
OI Pushpakaran, Bejoy/0000-0002-1342-5951
NR 22
TC 1
Z9 1
U1 3
U2 19
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1569-8025
J9 J COMPUT ELECTRON
JI J. Comput. Electron.
PD MAR
PY 2016
VL 15
IS 1
SI SI
BP 191
EP 199
DI 10.1007/s10825-015-0766-1
PG 9
WC Engineering, Electrical & Electronic; Physics, Applied
SC Engineering; Physics
GA DF5OU
UT WOS:000371402300023
ER
PT J
AU Gutmann, E
Barstad, I
Clark, M
Arnold, J
Rasmussen, R
AF Gutmann, Ethan
Barstad, Idar
Clark, Martyn
Arnold, Jeffrey
Rasmussen, Roy
TI The Intermediate Complexity Atmospheric Research Model (ICAR)
SO JOURNAL OF HYDROMETEOROLOGY
LA English
DT Article
DE Models and modeling; Atm/Ocean Structure/ Phenomena; Mountain
meteorology; Physical Meteorology and Climatology; Precipitation;
Mountain waves; Circulation/ Dynamics; Orographic effects; Applications;
Climate change; Regional models
ID CLIMATE-CHANGE IMPACTS; OROGRAPHIC PRECIPITATION; WINTER PRECIPITATION;
SPATIAL-DISTRIBUTION; UNITED-STATES; AIR-FLOW; IMPLEMENTATION;
SIMULATIONS; SENSITIVITY; CALIFORNIA
AB With limited computational resources, there is a need for computationally frugal models. This is particularly the case for atmospheric sciences, which have long relied on either simplistic analytical solutions or computationally expensive numerical models. The simpler solutions are inadequate for many problems, while the cost of numerical models makes their use impossible for many problems, most notably high-resolution climate downscaling applications spanning large areas, long time periods, and many global climate projections. Here the Intermediate Complexity Atmospheric Research model (ICAR) is presented to provide a new step along the modeling complexity continuum. ICAR leverages an analytical solution for high-resolution perturbations to wind velocities, in conjunction with numerical physics schemes, that is, advection and cloud microphysics, to simulate the atmosphere. The focus of the initial development of ICAR is for predictions of precipitation, and eventually temperature, humidity, and radiation at the land surface. Comparisons between ICAR and the Weather Research and Forecasting (WRF) Model for simulations over an idealized mountain are presented, as well as among ICAR, WRF, and the Parameter-Elevation Regressions on Independent Slopes Model (PRISM) observation-based product for a year-long simulation over the Colorado Rockies. In the ideal simulations, ICAR matches WRF precipitation predictions across a range of environmental conditions with a coefficient of determination r(2) of 0.92. In the Colorado Rockies, ICAR, WRF, and PRISM show very good agreement, with differences between ICAR and WRF comparable to the differences between WRF and PRISM in the cool season. For these simulations, WRF required 140-800 times more computational resources than ICAR.
C1 [Gutmann, Ethan; Clark, Martyn; Rasmussen, Roy] Natl Ctr Atmospher Res, Res Applicat Lab, POB 3000, Boulder, CO 80307 USA.
[Barstad, Idar] Uni Res Comp, Bergen, Norway.
[Arnold, Jeffrey] US Army Corps Engineers, Climate Preparedness & Resilience Programs, Seattle, WA USA.
RP Gutmann, E (reprint author), Natl Ctr Atmospher Res, Res Applicat Lab, POB 3000, Boulder, CO 80307 USA.
EM gutmann@ucar.edu
RI Gutmann, Ethan/I-5728-2012
OI Gutmann, Ethan/0000-0003-4077-3430
FU U.S. Army Corps of Engineers
FX This work was funded in part through a contract from the U.S. Army Corps
of Engineers and a cooperative agreement with the U.S. Bureau of
Reclamation. The authors thank Levi Brekke and David Raff for early
feedback on the utility of such an approach, Andrew Newman and Andreas
Prein for helpful discussions on atmospheric dynamics, and Justin Minder
for prompting us to think about spatial variations in the linear wind
field early on. All data and models used in this work are freely
available.
NR 53
TC 3
Z9 3
U1 1
U2 11
PU AMER METEOROLOGICAL SOC
PI BOSTON
PA 45 BEACON ST, BOSTON, MA 02108-3693 USA
SN 1525-755X
EI 1525-7541
J9 J HYDROMETEOROL
JI J. Hydrometeorol.
PD MAR
PY 2016
VL 17
IS 3
BP 957
EP 973
DI 10.1175/JHM-D-15-0155.1
PG 17
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA DF6OF
UT WOS:000371474400001
ER
PT J
AU Wan, C
Hu, MY
Borodin, O
Qian, JF
Qin, ZH
Zhang, JG
Hu, JZ
AF Wan, Chuan
Hu, Mary Y.
Borodin, Oleg
Qian, Jiangfeng
Qin, Zhaohai
Zhang, Ji-Guang
Hu, Jian Zhi
TI Natural abundance O-17, Li-6 NMR and molecular modeling studies of the
solvation structures of lithium
bis(fluorosulfonyl)imide/1,2-dimethoxyethane liquid electrolytes
SO JOURNAL OF POWER SOURCES
LA English
DT Article
DE Natural abundance O-17 and Li-6 NMR; Molecular modeling studies;
Electrolytes; Lithium bis(fluorosulfonyl)imide; 1,2-Dimethoxyethane;
Solvation structure
ID SOLID-STATE NMR; ION BATTERIES; SUPERCONCENTRATED ELECTROLYTES;
TRANSPORT MECHANISM; DYNAMICS; SOLVENTS; METAL; LI+; SIMULATIONS;
STABILITY
AB Natural abundance O-17 and Li-6 NMR experiments, quantum chemistry and molecular dynamics studies were employed to investigate the solvation structures of Li+ at various concentrations of LiFSI in DME electrolytes. It was found that the chemical shifts of both O-17 and Li-6 changed with the concentration of LiFSI, indicating the changes of solvation structures with concentration. For the quantum chemistry calculations, the coordinated cluster LiFSI(DME)(2) forms at first, and its relative ratio increases with increasing LiFSI concentration to 1 M. Then the solvation structure LiFSI(DME) become the dominant component. As a result, the coordination of forming contact ion pairs between Li+ and FSI- ion increases, but the association between Li+ and DME molecule decreases. Furthermore, at LiFSI concentration of 4 M the solvation structures associated with Li+(FSI-)(2)(DME), Li-2(+)(FSI-)(DME)(4) and (LiFSI)(2)(DME)(3) become the dominant components. For the molecular dynamics simulation, with increasing concentration, the association between DME and Li+ decreases, and the coordinated number of FSI- increases, which is in perfect accord with the DFT results. (C) 2015 Published by Elsevier B.V.
C1 [Wan, Chuan; Hu, Mary Y.; Qian, Jiangfeng; Zhang, Ji-Guang; Hu, Jian Zhi] Pacific NW Natl Lab, JCESR, Richland, WA 99354 USA.
[Wan, Chuan; Qin, Zhaohai] China Agr Univ, Coll Sci, Beijing 100193, Peoples R China.
[Borodin, Oleg] US Army, Electrochem Branch, Sensor & Electron Devices Directorate, Res Lab, Adelphi, MD 20783 USA.
RP Hu, JZ (reprint author), Pacific NW Natl Lab, JCESR, Richland, WA 99354 USA.
EM Jianzhi.Hu@pnnl.gov
RI Hu, Jian Zhi/F-7126-2012; Wan, Chuan/I-4657-2016
OI Wan, Chuan/0000-0002-8226-7619
FU Joint Center for Energy Storage Research (JCESR), an Energy Innovation
Hub - U.S. Department of Energy, Office of Science, Basic Energy
Sciences (BES); U.S. Department of Energy's (DOE's) Office of
Electricity Delivery and Energy Reliability [57558]; DOE's Office of
Biological and Environmental Research (BER); Department of Energy
[DE-AC05-76RLO1830]
FX This work was supported as part of the Joint Center for Energy Storage
Research (JCESR), an Energy Innovation Hub funded by the U.S. Department
of Energy, Office of Science, Basic Energy Sciences (BES). The NMR
sample preparations were supported by the funding from the U.S.
Department of Energy's (DOE's) Office of Electricity Delivery and Energy
Reliability (OE) (under Contract No. 57558). The NMR, and computational
studies were conducted in the William R. Wiley Environmental Molecular
Sciences Laboratory (EMSL), a national scientific user facility
sponsored by DOE's Office of Biological and Environmental Research (BER)
and located at PNNL. PNNL is operated by Battelle for the Department of
Energy under Contract DE-AC05-76RLO1830.
NR 34
TC 3
Z9 3
U1 14
U2 37
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-7753
EI 1873-2755
J9 J POWER SOURCES
JI J. Power Sources
PD MAR 1
PY 2016
VL 307
BP 231
EP 243
DI 10.1016/j.jpowsour.2015.12.120
PG 13
WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials
Science, Multidisciplinary
SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science
GA DE8KD
UT WOS:000370884000030
ER
PT J
AU Fan, XL
Zhu, YJ
Luo, C
Gao, T
Suo, LM
Liou, SC
Xu, K
Wang, CS
AF Fan, Xiulin
Zhu, Yujie
Luo, Chao
Gao, Tao
Suo, Liumin
Liou, Sz-Chian
Xu, Kang
Wang, Chunsheng
TI In situ lithiated FeF3/C nanocomposite as high energy
conversion-reaction cathode for lithium-ion batteries
SO JOURNAL OF POWER SOURCES
LA English
DT Article
DE Lithium-ion battery; Conversion reaction; Iron fluoride; Cathode
material; Prelithiation
ID METAL FLUORIDE NANOCOMPOSITES; IRON FLUORIDE; ELECTRODE MATERIALS; LI
BATTERIES; THIN-FILMS; PERFORMANCE; FABRICATION; INTERCALATION;
TRANSPORT; STORAGE
AB Transition metal fluorides (such as FeF3 and FeF2) based on conversion chemistry have been considered as a promising alternative to the intercalation cathode materials due to the high capacity and high energy density. However, the critical challenges for these materials come from the absence of Li source in them, and low power density and poor cycling stability. Herein, pre-lithiated FeF3 with extremely small size of Fe and LiF nanoparticles (both similar to 6 nm) homogeneously embedded in the carbon matrix were synthesized using a facile and scalable in situ strategy. Benefited from the ultra-small Fe and LiF nanoparticles, uniform distribution, and intimate contact between the active species and the carbon matrix, the particle-to-particle interfacial resistance and diffusion length for Li and F are dramatically reduced. As a result, a high specific capacity of over 400 mA h g(-1) with a discharge energy density of similar to 700 W h kg(-1) and favorable cycling performance are achieved, making such composite a promising high-capacity cathode for LIBs. Furthermore, the built-in Li source in this composite renders it a drop-in replacement for cathode materials used in the current LIB configurations, thus paving the way for the practical applications in the text generation of high energy density LIBs. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Fan, Xiulin; Zhu, Yujie; Luo, Chao; Gao, Tao; Suo, Liumin; Wang, Chunsheng] Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA.
[Liou, Sz-Chian] Univ Maryland, Maryland Nanoctr, College Pk, MD 20742 USA.
[Xu, Kang] US Army Res Lab, Power & Energy Div, Sensor & Electron Devices Directorate, Electrochem Branch, Adelphi, MD 20783 USA.
RP Wang, CS (reprint author), Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA.
EM cswang@umd.edu
RI Wang, Chunsheng/H-5767-2011
OI Wang, Chunsheng/0000-0002-8626-6381
FU Army Research Laboratory [W911NF1420031]; Maryland NanoCenter; NispLab
FX This work was supported by Army Research Laboratory under Award Number
W911NF1420031. The authors gratefully acknowledge the support of the
Maryland NanoCenter and its NispLab. The highly pure fluorinated
solvents were provided by Drs. Ron Hendershot and Joe Sundstrom of
Daikin America.
NR 41
TC 9
Z9 9
U1 51
U2 134
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-7753
EI 1873-2755
J9 J POWER SOURCES
JI J. Power Sources
PD MAR 1
PY 2016
VL 307
BP 435
EP 442
DI 10.1016/j.jpowsour.2016.01.004
PG 8
WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials
Science, Multidisciplinary
SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science
GA DE8KD
UT WOS:000370884000052
ER
PT J
AU Certal, VF
Pratas, R
Guimaraes, L
Lugo, R
Tsou, Y
Camacho, M
Capasso, R
AF Certal, Victor F.
Pratas, Rui
Guimaraes, Lidia
Lugo, Rodolfo
Tsou, Yungan
Camacho, Macario
Capasso, Robson
TI Awake examination versus DISE for surgical decision making in patients
with OSA: A systematic review
SO LARYNGOSCOPE
LA English
DT Review
DE DISE; obstructive sleep apnea
ID INDUCED SLEEP ENDOSCOPY; UPPER-AIRWAY-OBSTRUCTION; APNEA SYNDROME;
SURGERY; EXPERIENCE; MANAGEMENT; MANEUVER; SITES
AB ObjectiveTraditionally, upper airway examination is performed while the patient is awake. However, in the past two decades, drug-induced sleep endoscopy (DISE) has been used as a method of tridimensional evaluation of the upper airway during pharmacologically induced sleep. This study aimed to systematically review the evidence regarding the usefulness of DISE compared with that of traditional awake examination for surgical decision making in patients with obstructive sleep apnea (OSA).
Data SourcesScopus, PubMed, and Cochrane Library databases were searched.
Review MethodsOnly studies with a primary objective of evaluating the usefulness of DISE for surgical decision making in patients with OSA were selected. The included studies directly compared awake examination data with DISE outcome data in terms of possible influences on surgical decision making and operation success.
ResultsA total of eight studies with 535 patients were included in this review. Overall, the surgical treatment changed after DISE in 50.24% (standard deviation 8.4) cases. These changes were more frequently associated with structures contributing to hypopharyngeal or laryngeal obstruction. However, these differences do not automatically indicate a higher success rate.
ConclusionThis review emphasized the direct impact of DISE compared with that of awake examination on surgical decision making in OSA patients. However, it is also clear that the available published studies lack evidence on the association between this impact and surgical outcomes. Laryngoscope, 126:768-774, 2016
C1 [Certal, Victor F.] Univ Porto, CINTESIS, Ctr Res Hlth Technol & Informat Syst, Rua Campo Alegre 823, P-4100 Oporto, Portugal.
[Certal, Victor F.; Pratas, Rui; Guimaraes, Lidia] Hosp CUF, Sleep Med Ctr, Dept Otorhinolaryngol, Oporto, Portugal.
[Certal, Victor F.; Pratas, Rui; Guimaraes, Lidia] Hosp Sao Sebastiao, Oporto, Portugal.
[Lugo, Rodolfo] Grp Med San Pedro, Dept Otorhinolaryngol, Monterrey, Mexico.
[Tsou, Yungan] China Med Univ Hosp, Div Sleep Surg & Med, Dept Otolaryngol, Taichung, Taiwan.
[Camacho, Macario] Tripler Army Med Ctr, Dept Otorhinolaryngol, Div Sleep Surg & Med, Honolulu, HI 96859 USA.
[Capasso, Robson] Stanford Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Sleep Surg Div, Stanford, CA 94305 USA.
RP Certal, VF (reprint author), Hosp CUF Porto, Serv Otorrinolaringol, Estr Circunvalacao 14341, P-4100180 Oporto, Portugal.
EM victorcertal@gmail.com
RI FMUP, CINTESIS/C-6631-2014;
OI FMUP, CINTESIS/0000-0001-7248-2086; Camacho, Macario/0000-0001-9200-9085
NR 41
TC 4
Z9 4
U1 0
U2 7
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0023-852X
EI 1531-4995
J9 LARYNGOSCOPE
JI Laryngoscope
PD MAR
PY 2016
VL 126
IS 3
BP 768
EP 774
DI 10.1002/lary.25722
PG 7
WC Medicine, Research & Experimental; Otorhinolaryngology
SC Research & Experimental Medicine; Otorhinolaryngology
GA DF3KM
UT WOS:000371242800052
PM 26484801
ER
PT J
AU Rivera, LO
Jackson, DD
Rivera, MS
Murray, E
Waardenburg, T
Jenkins, K
Wahl, D
Mitvalsky, LA
Hoover, TA
AF Rivera, Luis Omar
Jackson, Dawnyea D.
Rivera, Moira Shaw
Murray, Elizabeth
Waardenburg, Tiffany
Jenkins, Kathryn
Wahl, David
Mitvalsky, Laura A.
Hoover, Todd A.
TI BUILDING EFFICIENCY AND QUALITY IN HEALTH EDUCATION The Army Wellness
Center Model
SO ACSMS HEALTH & FITNESS JOURNAL
LA English
DT Article
DE Primary Prevention; Health Coaching; Behavior Change; Worksite Wellness
ID PROMOTION PROGRAMS; OBESITY; WORK; POPULATION
C1 [Rivera, Luis Omar] US Army, Inst Publ Hlth, Hlth Promot & Wellness Directorate, Rochester, MI USA.
[Rivera, Luis Omar] Army Wellness Ctr, Lawton, OK 73503 USA.
[Jackson, Dawnyea D.] US Army, Inst Publ Hlth, Hlth Promot & Wellness Portfolio, Publ Hlth Assessment Program, Rochester, MI USA.
[Rivera, Moira Shaw] Contracting Resources Grp, Publ Hlth Evaluat Div, Rochester, MI USA.
[Rivera, Moira Shaw; Hoover, Todd A.] US Army, Publ Hlth Ctr Provis, Army Inst Publ Hlth, Rochester, MI USA.
[Murray, Elizabeth] Army Wellness Ctr, Carlisle, PA USA.
[Waardenburg, Tiffany] Army Wellness Ctr Carlisle Barracks, Carlisle, PA USA.
[Jenkins, Kathryn] Vicenza Community, Vicenza, Italy.
[Wahl, David] Army Wellness Ctr Bavaria, Vilseck, Germany.
[Mitvalsky, Laura A.] US Army, Publ Hlth Ctr Provis, Hlth Promot & Wellness Directorate, Army Inst Publ Hlth, Rochester, MI USA.
[Hoover, Todd A.] Army Wellness Ctr Initiat, Rochester, MI USA.
RP Rivera, LO (reprint author), US Army, Inst Publ Hlth, Hlth Promot & Wellness Directorate, Rochester, MI USA.; Rivera, LO (reprint author), Army Wellness Ctr, Lawton, OK 73503 USA.
FU U.S. Army Public Health Center (Provisional); Oak Ridge Institute for
Science and Education
FX The views expressed in this article are those of the author(s) and do
not necessarily reflect the official policy of the Department of
Defense, Department of the Army, U.S. Army Medical Department, or the
U.S. Government.; This project was funded by the U.S. Army Public Health
Center (Provisional) and the Oak Ridge Institute for Science and
Education.
NR 11
TC 0
Z9 0
U1 2
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1091-5397
EI 1536-593X
J9 ACSMS HEALTH FIT J
JI ACSMS Health Fit. J.
PD MAR-APR
PY 2016
VL 20
IS 2
BP 19
EP 23
PG 5
WC Sport Sciences
SC Sport Sciences
GA DE2WE
UT WOS:000370487100006
ER
PT J
AU Kuhn, JH
Lauck, M
Bailey, AL
Shchetinin, AM
Vishnevskaya, TV
Bao, YM
Ng, TFF
LeBreton, M
Schneider, BS
Gillis, A
Tamoufe, U
Diffo, JL
Takuo, JM
Kondov, NO
Coffey, LL
Wolfe, ND
Delwart, E
Clawson, AN
Postnikova, E
Bollinger, L
Lackemeyer, MG
Radoshitzky, SR
Palacios, G
Wada, J
Shevtsova, ZV
Jahrling, PB
Lapin, BA
Deriabin, PG
Dunowska, M
Alkhovsky, SV
Rogers, J
Friedrich, TC
O'Connor, DH
Goldberg, TL
AF Kuhn, Jens H.
Lauck, Michael
Bailey, Adam L.
Shchetinin, Alexey M.
Vishnevskaya, Tatyana V.
Bao, Yiming
Ng, Terry Fei Fan
LeBreton, Matthew
Schneider, Bradley S.
Gillis, Amethyst
Tamoufe, Ubald
Diffo, Joseph Le Doux
Takuo, Jean Michel
Kondov, Nikola O.
Coffey, Lark L.
Wolfe, Nathan D.
Delwart, Eric
Clawson, Anna N.
Postnikova, Elena
Bollinger, Laura
Lackemeyer, Matthew G.
Radoshitzky, Sheli R.
Palacios, Gustavo
Wada, Jiro
Shevtsova, Zinaida V.
Jahrling, Peter B.
Lapin, Boris A.
Deriabin, Petr G.
Dunowska, Magdalena
Alkhovsky, Sergey V.
Rogers, Jeffrey
Friedrich, Thomas C.
O'Connor, David H.
Goldberg, Tony L.
TI Reorganization and expansion of the nidoviral family Arteriviridae
SO ARCHIVES OF VIROLOGY
LA English
DT Article
ID SIMIAN HEMORRHAGIC-FEVER; EQUINE ARTERITIS VIRUS; RESPIRATORY SYNDROME
VIRUS; SUBGENOMIC MESSENGER-RNAS; ISOLATE ATCC VR-2332; INTERNATIONAL
COMMITTEE; STANDARDIZED NOMENCLATURE; TAXONOMIC PROPOSALS; RATIFICATION
VOTE; SPECIES LEVEL
AB The family Arteriviridae presently includes a single genus Arterivirus. This genus includes four species as the taxonomic homes for equine arteritis virus (EAV), lactate dehydrogenase-elevating virus (LDV), porcine respiratory and reproductive syndrome virus (PRRSV), and simian hemorrhagic fever virus (SHFV), respectively. A revision of this classification is urgently needed to accommodate the recent description of eleven highly divergent simian arteriviruses in diverse African nonhuman primates, one novel arterivirus in an African forest giant pouched rat, and a novel arterivirus in common brushtails in New Zealand. In addition, the current arterivirus nomenclature is not in accordance with the most recent version of the International Code of Virus Classification and Nomenclature. Here we outline an updated, amended, and improved arterivirus taxonomy based on current data. Taxon-specific sequence cut-offs are established relying on a newly established open reading frame 1b phylogeny and pairwise sequence comparison (PASC) of coding-complete arterivirus genomes. As a result, the current genus Arterivirus is replaced by five genera: Equartevirus (for EAV), Rodartevirus (LDV + PRRSV), Simartevirus (SHFV + simian arteriviruses), Nesartevirus (for the arterivirus from forest giant pouched rats), and Dipartevirus (common brushtail arterivirus). The current species Porcine reproductive and respiratory syndrome virus is divided into two species to accommodate the clear divergence of the European and American "types" of PRRSV, both of which now receive virus status. The current species Simian hemorrhagic fever virus is divided into nine species to accommodate the twelve known simian arteriviruses. Non-Latinized binomial species names are introduced to replace all current species names to clearly differentiate them from virus names, which remain largely unchanged.
C1 [Kuhn, Jens H.; Clawson, Anna N.; Postnikova, Elena; Bollinger, Laura; Lackemeyer, Matthew G.; Wada, Jiro; Jahrling, Peter B.] NIAID, Integrated Res Facil Ft Detrick IRF Frederick, Div Clin Res, NIH, B-8200 Res Plaza, Frederick, MD 21702 USA.
[Friedrich, Thomas C.; Goldberg, Tony L.] Univ Wisconsin, Sch Vet Med, Dept Pathobiol Sci, Madison, WI 53706 USA.
[Shchetinin, Alexey M.; Vishnevskaya, Tatyana V.; Deriabin, Petr G.; Alkhovsky, Sergey V.] Minist Hlth Russian Federat, DI Ivanovskii Virol Inst, Fed Res Ctr Epidemiol & Microbiol, Moscow, Russia.
[Bao, Yiming] NIH, Informat Engn Branch, Natl Ctr Biotechnol Informat, Natl Lib Med, Bldg 10, Bethesda, MD 20892 USA.
[Ng, Terry Fei Fan; Kondov, Nikola O.; Delwart, Eric] Blood Syst Res Inst, San Francisco, CA USA.
[LeBreton, Matthew] Mosaic, Yaounde, Cameroon.
[LeBreton, Matthew; Schneider, Bradley S.; Gillis, Amethyst; Wolfe, Nathan D.] Metabiota, San Francisco, CA USA.
[Tamoufe, Ubald; Diffo, Joseph Le Doux; Takuo, Jean Michel] Global Viral Cameroon, Yaounde, Cameroon.
[Radoshitzky, Sheli R.; Palacios, Gustavo] US Army, Med Res Inst Infect Dis, Frederick, MD USA.
[Shevtsova, Zinaida V.] Sci Res Inst Expt Pathol & Therapy, Sukhumi, Autonomous Repu, Rep of Georgia.
[Lapin, Boris A.] Russian Acad Med Sci, Sci Res Inst Med Primatol, Soci, Russia.
[Dunowska, Magdalena] Massey Univ, Inst Vet Anim & Biomed Sci, Palmerston North, New Zealand.
[Rogers, Jeffrey] Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX 77030 USA.
[Lauck, Michael; Bailey, Adam L.; Friedrich, Thomas C.; O'Connor, David H.; Goldberg, Tony L.] Wisconsin Natl Primate Res Ctr, Madison, WI 53715 USA.
[Coffey, Lark L.] Univ Calif Davis, Ctr Vectorborne Dis, Dept Pathol Microbiol & Immunol, Sch Vet Med, Davis, CA 95616 USA.
[O'Connor, David H.] Univ Wisconsin, Dept Pathol & Lab Med, Sch Med & Publ Hlth, Madison, WI 53706 USA.
RP Kuhn, JH (reprint author), NIAID, Integrated Res Facil Ft Detrick IRF Frederick, Div Clin Res, NIH, B-8200 Res Plaza, Frederick, MD 21702 USA.; Goldberg, TL (reprint author), Univ Wisconsin, Sch Vet Med, Dept Pathobiol Sci, Madison, WI 53706 USA.; Goldberg, TL (reprint author), Wisconsin Natl Primate Res Ctr, Madison, WI 53715 USA.
EM kuhnjens@mail.nih.gov; tgoldberg@vetmed.wisc.edu
RI Palacios, Gustavo/I-7773-2015;
OI Palacios, Gustavo/0000-0001-5062-1938; Shchetinin,
Alexey/0000-0003-1842-3899; Schneider, Bradley S/0000-0001-7642-0018;
Vishnevskaya, Tatyana/0000-0002-6963-8681; Kuhn, Jens
H./0000-0002-7800-6045; Lauck, Michael/0000-0003-2813-3705
FU Battelle Memorial Institute's prime [HHSN272200700016I]; National
Institutes of Health (NIH) as part of the joint NIH-NSF Ecology of
Infectious Disease program [TW009237, R01 AI077376]; Office of Research
Infrastructure Programs (ORIP) [P51OD011106]; Intramural Research
Program of the National Institutes of Health; National Library of
Medicine
FX This work was funded in part through Battelle Memorial Institute's prime
contract with the US National Institute of Allergy and Infectious
Diseases (NIAID) under Contract No. HHSN272200700016I. Battelle
employees involved in this work are: L.B. and J.W. Subcontractors to
Battelle Memorial Institute who performed this work are: J.H.K and E.P.,
employees of Tunnell Government Services, Inc.; A.N.C. the owner of
Logos Consulting, Inc.; and M.G.L., an employee of Lovelace Respiratory
Research Institute. This work was also funded in part through National
Institutes of Health (NIH) grant TW009237 as part of the joint NIH-NSF
Ecology of Infectious Disease program, grant R01 AI077376, and by the
Office of Research Infrastructure Programs (ORIP) grant P51OD011106.
This research was also supported in part by the Intramural Research
Program of the National Institutes of Health, National Library of
Medicine (Y.B.), and benefited from contributions from the PREDICT
project of the United States Agency for International Development
(USAID) Emerging Pandemic Threats Program. We thank the Cameroon
government for their support during the implementation of this project.
NR 59
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U2 5
PU SPRINGER WIEN
PI WIEN
PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA
SN 0304-8608
EI 1432-8798
J9 ARCH VIROL
JI Arch. Virol.
PD MAR
PY 2016
VL 161
IS 3
BP 755
EP 768
DI 10.1007/s00705-015-2672-z
PG 14
WC Virology
SC Virology
GA DF0SR
UT WOS:000371049800034
PM 26608064
ER
PT J
AU Brown, C
Griggs, T
Keene, T
Marra, M
Skousen, J
AF Brown, Carol
Griggs, Thomas
Keene, Travis
Marra, Mike
Skousen, Jeff
TI Switchgrass Biofuel Production on Reclaimed Surface Mines: I. Soil
Quality and Dry Matter Yield
SO BIOENERGY RESEARCH
LA English
DT Article
DE Biomass; Carthage; Cave-in-Rock; Harvest management; Revegetation;
Shawnee; Switchgrass fertilization
ID BIOMASS PRODUCTION; BIOENERGY PRODUCTION; NITROGEN; USA; FEEDSTOCK;
HARVEST; MANAGEMENT; FREQUENCY; LOWLAND; MIDWEST
AB Growing food crops for biofuel on productive agricultural lands may become less viable as requirements to feed a growing human population increase. This has increased interest in growing cellulosic biofuel feedstocks on marginal lands. Switchgrass (Panicum virgatum L.), a warm-season perennial, is a viable bioenergy crop candidate because it produces high yields on marginal lands under low fertility conditions. In other studies, switchgrass dry matter (DM) yields on marginal croplands varied from 5.0 to 10.0 Mg ha(-1) annually. West Virginia contains immense areas of reclaimed surface mined lands that could support a switchgrass-based biofuel industry, but yield data on these lands are lacking. Field experiments were established in 2008 to determine yields of three switchgrass cultivars on two West Virginia mine sites. One site reclaimed with topsoil and municipal sludge produced biomass yields of 19.0 Mg DM ha(-1) for Cave-in-Rock switchgrass after the sixth year, almost double the varieties Shawnee and Carthage, at 10.0 and 5.7 Mg ha(-1), respectively. Switchgrass yields on another site with no topsoil were 1.0 Mg ha(-1) after the sixth year, with little variation among cultivars. A second experiment was conducted at two other mine sites with a layer of topsoil over gray overburden. Cave-in-Rock was seeded with fertilizer applications of 0, 34, and 68 kg N-P2O5-K2O ha(-1). After the third year, the no fertilizer treatment averaged biomass yields of 0.3 Mg ha(-1), while responses to the other two rates averaged 1.1 and 2.0 Mg ha(-1), respectively. Fertilization significantly increased yields on reclaimed mine soils. Where mine soil fertility was good, yields were similar to those reported on agricultural soils in the Northeastern USA.
C1 [Brown, Carol; Griggs, Thomas; Skousen, Jeff] W Virginia Univ, Div Plant & Soil Sci, Morgantown, WV 26506 USA.
[Keene, Travis] Mycogen Seeds, Lancaster, PA 17601 USA.
[Marra, Mike] US Army Corps Engn, San Antonio, TX 78258 USA.
RP Skousen, J (reprint author), W Virginia Univ, Div Plant & Soil Sci, Morgantown, WV 26506 USA.
EM jskousen@wvu.edu
FU West Virginia Department of Environmental Protection; NEWBio Northeast
Woody/Warm-season Grass Biomass Consortium; Hatch Act at West Virginia
University
FX This research was funded by the West Virginia Department of
Environmental Protection, the NEWBio Northeast Woody/Warm-season Grass
Biomass Consortium, and with funds appropriated under the Hatch Act at
West Virginia University. Scientific article from the West Virginia
Agricultural and Forestry Experiment Station. The authors thank Rick
Herd, Brady Gutta, Paul Ziemkiewicz, Ken Ellison, Scott Schumaker,
Rodney Mangold, John McHale, Kenny Daniel, George Thornsbury, Rick
Adams, Terry Potter, Kermit Fincham, David McMichael, and Marcus
McCartney for help with project development, site access, and analysis
during the study.
NR 33
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PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1939-1234
EI 1939-1242
J9 BIOENERG RES
JI BioEnergy Res.
PD MAR
PY 2016
VL 9
IS 1
BP 31
EP 39
DI 10.1007/s12155-015-9658-2
PG 9
WC Energy & Fuels; Environmental Sciences
SC Energy & Fuels; Environmental Sciences & Ecology
GA DE7KV
UT WOS:000370816300004
ER
PT J
AU Nieves, JW
Ruffing, JA
Zion, M
Tendy, S
Yavorek, T
Lindsay, R
Cosman, F
AF Nieves, Jeri W.
Ruffing, Jamie A.
Zion, Marsha
Tendy, Susan
Yavorek, Trudy
Lindsay, Robert
Cosman, Felicia
TI Eating disorders, menstrual dysfunction, weight change and DMPA use
predict bone density change in college-aged women
SO BONE
LA English
DT Article
DE Peak bone mass; Menstrual dysfunction; Eating disorders; DMPA; Oral
contraceptives; Weight loss
ID DIETARY CALCIUM INTAKE; ORAL-CONTRACEPTIVE USE; STRESS-FRACTURE RISK;
FEMALE ATHLETE TRIAD; MINERAL DENSITY; PHYSICAL-ACTIVITY;
ANOREXIA-NERVOSA; FEMORAL-NECK; YOUNG-ADULTS; MASS
AB Introduction: There are limited longitudinal studies that have evaluated bone mineral density (BMD) changes in college-aged women. Our objective was to simultaneously evaluate factors influencing 4-year BMD change.
Methods: This was a longitudinal cohort study of healthy, physically active women in the US Military Academy (n = 91; average age = 18.4 years). Assessments over four years included: height, weight, calcium intake, physical fitness, menstrual function (annual number cycles), oral contraceptives (OCs) or depotmedroxyprogesterone acetate (DMPA) use, and eating disorder behavior (Eating Disorder Inventory; (EDI)). BMD was measured annually at the lumbar spine and total hip by dual X-ray absorptiometry and calcaneal BMD by PIXI. Slope of 4 year BMD change at each skeletal site (spine total hip and calcaneus) was calculated for each woman.
Results: BMD gains occurred at the spine in 50% and the hip in 36% of women. In unadjusted analyses, spine bone gain was positively related to menstrual cycle frequency (p = 0.04). Spine and hip BMD loss occurred in those using DMPA (p < 0.01) and those with the highest EDI quartile scores (p < 0.05). BMD change was unrelated to OC use. Hip and calcaneus BMD decreased with weight loss (average 4.8 + 2.2 lb/year) as compared to those with stable weight/weight gain (p < 0.05). In multivariable analysis, spine BMD increase was significantly related to African American (AA) race, normal EDI score and normal menses. Hip BMD increase was related to AA race, weight increase and normal menses. DMPA use was associated with spine, hip, and calcaneus bone loss.
Conclusion: On average, BMD may modestly increase in college-aged women, in the absence of risk factors. However, risk factors including subclinical eating disorders, weight loss, menstrual dysfunction and DMPA use can have significant detrimental effects on BMD in young healthy physically active women. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Nieves, Jeri W.; Ruffing, Jamie A.; Zion, Marsha; Lindsay, Robert; Cosman, Felicia] Helen Hayes Hosp, Clin Res Ctr, Route 9W, W Haverstraw, NY 10993 USA.
[Nieves, Jeri W.; Ruffing, Jamie A.; Zion, Marsha; Lindsay, Robert; Cosman, Felicia] Helen Hayes Hosp, Reg Bone Ctr, Route 9W, W Haverstraw, NY 10993 USA.
[Lindsay, Robert; Cosman, Felicia] Columbia Univ Coll Phys & Surg, Dept Med, New York, NY USA.
[Nieves, Jeri W.; Ruffing, Jamie A.] Columbia Univ, Dept Epidemiol, Mailman Sch Publ Hlth, New York, NY 10027 USA.
[Tendy, Susan; Yavorek, Trudy] US Mil Acad, West Point, NY 10996 USA.
RP Nieves, JW (reprint author), Helen Hayes Hosp, Clin Res Ctr, Route 9W, W Haverstraw, NY 10993 USA.
EM nievesj@helenhayeshosp.org
FU U.S. Army Medical Research and Materiel Command [DAMD17-98-1-8539]
FX This study was funded by a grant from the U.S. Army Medical Research and
Materiel Command; award number DAMD17-98-1-8539.
NR 44
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U1 2
U2 11
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 8756-3282
EI 1873-2763
J9 BONE
JI Bone
PD MAR
PY 2016
VL 84
BP 113
EP 119
DI 10.1016/j.bone.2015.12.054
PG 7
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA DE8VK
UT WOS:000370914600014
PM 26746778
ER
PT J
AU Schiffmacher, EN
Becker, JG
Lorah, MM
Voytek, MA
AF Schiffmacher, Emily N.
Becker, Jennifer G.
Lorah, Michelle M.
Voytek, Mary A.
TI The effects of co-contaminants and native wetland sediments on the
activity and dominant transformation mechanisms of a
1,1,2,2-tetrachloroethane (TeCA)-degrading enrichment culture
SO CHEMOSPHERE
LA English
DT Article
DE 1,1,2,2-Tetrachloroethane; Carbon tetrachloride; Tetrachloroethene;
Contaminated wetlands; Dehalococcoides; Dehalobacter
ID REDUCTIVE DECHLORINATION; CARBON-TETRACHLORIDE; VINYL-CHLORIDE;
DEHALOCOCCOIDES-ETHENOGENES; CHLORINATED SOLVENTS; CIS-DICHLOROETHENE;
CHLOROFORM; KINETICS; BIOTRANSFORMATION; DICHLOROMETHANE
AB Bioremediation strategies, including bioaugmentation with chlorinated ethene-degrading enrichment cultures, have been successfully applied in the cleanup of subsurface environments contaminated with tetrachloroethene (PCE) and/or trichloroethene (TCE). However, these compounds are frequently found in the environment as components of mixtures that may also contain chlorinated ethanes and methanes. Under these conditions, the implementation of bioremediation may be complicated by inhibition effects, particularly when multiple dehalorespirers are present. We investigated the ability of the 1,1,2,2-tetrachloroethane (TeCA)-dechlorinating culture WBC-2 to biotransform TeCA alone, or a mixture of TeCA plus PCE and carbon tetrachloride (CT), in microcosms. The microcosms contained electron donors provided to biostimulate the added culture and sediment collected from a wetland where numerous "hotspots" of contamination with chlorinated solvent mixtures exist. The dominant TeCA biodegradation mechanism mediated by the WBC-2 culture in the microcosms was different in the presence of these wetland sediments than in the sediment-free enrichment culture or in previous WBC-2 bioaugmented microcosms and column tests conducted with wetland sediment collected at nearby sites. The co-contaminants and their daughter products also inhibited TeCA biodegradation by WBC-2. These results highlight the need to conduct biodegradability assays at new sites, particularly when multiple contaminants and dehalorespiring populations are present. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Schiffmacher, Emily N.; Becker, Jennifer G.] Univ Maryland, Dept Environm Sci & Technol, College Pk, MD 20742 USA.
[Lorah, Michelle M.] US Geol Survey, MD DE DC Water Sci Ctr, 5522 Res Pk Dr, Catonsville, MD 21228 USA.
[Voytek, Mary A.] US Geol Survey, Natl Ctr 430, Reston, VA 20192 USA.
[Becker, Jennifer G.] Michigan Technol Univ, Dept Civil & Environm Engn, Houghton, MI 49931 USA.
[Schiffmacher, Emily N.] US Army Corps Engineers, Baltimore, MD USA.
[Voytek, Mary A.] NASA, Sci Mission Directorate, Washington, DC 20546 USA.
RP Becker, JG (reprint author), Michigan Technol Univ, Dept Civil & Environm Engn, Houghton, MI 49931 USA.
EM emily.schiffmacher@gmail.com; jgbecker@mtu.edu; mmlorah@usgs.gov;
mary.voytek-1@nasa.gov
FU United States Geological Survey; U.S. Army Environmental Conservation
and Restoration Division Aberdeen Proving Ground; Maryland Water
Resources Research Center
FX This work was supported, in part, through funding from the United States
Geological Survey through a contract with the U.S. Army Environmental
Conservation and Restoration Division Aberdeen Proving Ground, and the
Maryland Water Resources Research Center, which is sponsored by the
United States Geological Survey. Elizabeth J. P. Jones provided the
WBC-2 culture and many helpful suggestions and insights throughout this
study. Any use of trade, firm, or product names is for descriptive
purposes only and does not imply endorsement by the U.S. Government.
NR 34
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U1 3
U2 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0045-6535
EI 1879-1298
J9 CHEMOSPHERE
JI Chemosphere
PD MAR
PY 2016
VL 147
BP 239
EP 247
DI 10.1016/j.chemosphere.2015.12.033
PG 9
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA DE7SD
UT WOS:000370836100031
PM 26766361
ER
PT J
AU Boddu, VM
Brenner, MW
Patel, JS
Kumar, A
Mantena, PR
Tadepalli, T
Pramanik, B
AF Boddu, Veera M.
Brenner, Matthew W.
Patel, Jignesh S.
Kumar, Ashok
Mantena, P. Raju
Tadepalli, Tezeswi
Pramanik, Brahmananda
TI Energy dissipation and high-strain rate dynamic response of E-glass
fiber composites with anchored carbon nanotubes
SO COMPOSITES PART B-ENGINEERING
LA English
DT Article
DE Mechanical properties; Glass fibres; Nano-structures; Mechanical testing
ID BALLISTIC-PROTECTION PERFORMANCE; MECHANICAL-PROPERTIES; POLYMER
COMPOSITES; EPOXY COMPOSITE; NANOCOMPOSITES; BEHAVIOR; ARMOR; SCIENCE;
SURFACE
AB This study explores the mechanical properties of an E-glass fabric composite reinforced with anchored multi-walled carbon nanotubes (CNTs). The CNTs were grown on the E-glass fabric using a floating catalyst chemical vapor deposition procedure. The E-glass fabric with attached CNTs was then incorporated into resin based composites and compared to similar composites without CNTs. Long and short beam bending tests, uniaxial compression measurements for energy dissipation, high strain-rate Split Hopkinson pressure bar measurements, and ballistic performance (V50) tests were performed to characterize the mechanical properties of the CNT composites. The CNT composites showed a reduction in interlaminar shear strength by 25.9%. They also showed an increase in the specific energy absorption by 106% at high strain rates and an increase in energy density dissipation by 643% after 5 cycles at quasi static strain rates. In ballistic V50 tests, the CNT based composites showed a higher V50 value by 11.1%. Due to their reduced weight and energy dissipation properties, the direct growth of CNTs on E-glass fabrics incorporated into composites have potential defense applications such as blast protection. Published by Elsevier Ltd.
C1 [Boddu, Veera M.; Brenner, Matthew W.; Patel, Jignesh S.; Kumar, Ashok] US Army, ERDC, CERL, Champaign, IL 61821 USA.
[Mantena, P. Raju; Tadepalli, Tezeswi; Pramanik, Brahmananda] Univ Mississippi, Dept Mech Engn, Composite Struct & Nanoengn Res, University, MS 38677 USA.
[Tadepalli, Tezeswi] NIT, Dept Civil Engn, Warangal 5060004, TS, India.
[Pramanik, Brahmananda] Univ Montana, Montana Tech, Dept Gen Engn, Butte, MT 59701 USA.
RP Boddu, VM (reprint author), US Army, ERDC, CERL, Champaign, IL 61821 USA.; Boddu, VM (reprint author), ARS, Plant Polymer Res Unit, Natl Ctr Agr Res Ctr, USDA, 1815 N Univ St, Peoria, IL 61604 USA.
EM veera.boddu@ars.usda.gov
NR 56
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U1 10
U2 26
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1359-8368
EI 1879-1069
J9 COMPOS PART B-ENG
JI Compos. Pt. B-Eng.
PD MAR 1
PY 2016
VL 88
BP 44
EP 54
DI 10.1016/j.compositesb.2015.10.028
PG 11
WC Engineering, Multidisciplinary; Materials Science, Composites
SC Engineering; Materials Science
GA DE8NT
UT WOS:000370893500006
ER
PT J
AU Liebert, H
AF Liebert, Hugh
TI THE ACHAEAN LEAGUE AND THE AMERICAN FOUNDING
SO HISTORY OF POLITICAL THOUGHT
LA English
DT Article
DE Achaean League; American Founding; James Madison; Polybius; Aristotle;
Plato; Confederacy; Confederation; Ancient Confederations; The
Federalist Papers; US Constitution; Federalism; Ancient and Modern
Political Science; James Monroe; Ratification Debates; American
Classicism; Debates in the Federal Convention of 1787; Notes on Ancient
and Modern Confederacies
AB This paper reassesses the influence of ancient confederacies on the political thought of the American founding. It suggests that James Madison drew inspiration for innovative elements of the American Constitution from the Achaean League. It also claims that attention to Madison's debts, which he tallied in both Federalist no. 18 and the earlier 'Notes on Ancient and Modem Confederacies,' helps us to appreciate what Madison took to be perhaps the most innovative feature of the American founding not necessarily the Constitution that was established, but the manner in which its establishment was recorded and defended.
C1 [Liebert, Hugh] US Mil Acad, Dept Social Sci, 607 Cullum Rd, West Point, NY 10996 USA.
RP Liebert, H (reprint author), US Mil Acad, Dept Social Sci, 607 Cullum Rd, West Point, NY 10996 USA.
EM hugh.liebert@usma.edu
NR 52
TC 0
Z9 0
U1 0
U2 1
PU IMPRINT ACADEMIC
PI EXETER
PA PO BOX 200, EXETER EX5 5YX, DEVON, ENGLAND
SN 0143-781X
J9 HIST POLIT THOUGHT
JI Hist. Polit. Thought
PD SPR
PY 2016
VL 37
IS 1
BP 57
EP 77
PG 21
WC History
SC History
GA DE6TT
UT WOS:000370767200003
ER
PT J
AU Jia, M
Gingrich, E
Wang, H
Li, YP
Ghandhi, JB
Reitz, RD
AF Jia, Ming
Gingrich, Eric
Wang, Hu
Li, Yaopeng
Ghandhi, Jaal B.
Reitz, Rolf D.
TI Effect of combustion regime on in-cylinder heat transfer in internal
combustion engines
SO INTERNATIONAL JOURNAL OF ENGINE RESEARCH
LA English
DT Article
DE Multi-dimensional model; heat transfer loss; combustion regime;
reactivity controlled compression ignition; energy balance; empirical
heat transfer correlation
ID CONTROLLED COMPRESSION IGNITION; DIESEL-ENGINE; TRANSFER COEFFICIENT;
CONVENTIONAL DIESEL; TEMPERATURE; SIMULATIONS; DENSITY; MODELS; FLOWS
AB A multi-dimensional model was applied to investigate the influence of combustion regimes on heat transfer losses in internal combustion engines. By utilizing improved turbulence and heat transfer sub-models, the combustion and heat transfer characteristics of the engine were satisfactorily reproduced for operation under conventional diesel combustion, homogeneous charge compression ignition, and reactivity controlled compression ignition regimes. The results indicated that the total heat transfer losses of conventional diesel combustion are the largest among the three combustion regimes due to the direct interaction of the high-temperature flame with the piston wall, while the heat transfer losses of reactivity controlled compression ignition are the lowest and nearly are independent of combustion phasing because of the avoidance of high-temperature regions adjacent to the cylinder walls. Compared to conventional diesel combustion, homogeneous charge compression ignition shows more potential for the reduction of exhaust energy and improvement of fuel efficiency. In reactivity controlled compression ignition combustion, the reduction of heat transfer and exhaust losses outweigh its increase in combustion losses and offer the opportunity for further improvement of fuel efficiency. Furthermore, by evaluating the widely used Woschni and Chang et al.'s empirical heat transfer correlations, it was found that both correlations considerably overestimate the heat transfer rate for the reactivity controlled compression ignition regime. It is necessary to improve empirical heat transfer models to take account of the flow and combustion characteristics under various combustion modes.
C1 [Jia, Ming; Li, Yaopeng] Dalian Univ Technol, Sch Energy & Power Engn, Dalian 116024, Peoples R China.
[Jia, Ming; Gingrich, Eric; Wang, Hu; Ghandhi, Jaal B.; Reitz, Rolf D.] Univ Wisconsin, Engine Res Ctr, Madison, WI USA.
[Gingrich, Eric] US Army Tank Automot Res, Ctr Dev & Engn, Warren, MI USA.
RP Jia, M (reprint author), Dalian Univ Technol, Sch Energy & Power Engn, Dalian 116024, Peoples R China.
EM jiaming@dlut.edu.cn
RI Wang, Hu /O-5643-2015
OI Wang, Hu /0000-0002-7486-4763
FU National Natural Science Foundation of China [51176020]; National Basic
Research Project of China [2013CB228400]
FX The author(s) disclosed receipt of the following financial support for
the research, authorship, and/or publication of this article: This work
was funded by the National Natural Science Foundation of China (Grant
No. 51176020) and National Basic Research Project of China (Grant No.
2013CB228400).
NR 58
TC 3
Z9 3
U1 5
U2 14
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1468-0874
EI 2041-3149
J9 INT J ENGINE RES
JI Int. J. Engine Res.
PD MAR
PY 2016
VL 17
IS 3
BP 331
EP 346
DI 10.1177/1468087415575647
PG 16
WC Thermodynamics; Engineering, Mechanical; Transportation Science &
Technology
SC Thermodynamics; Engineering; Transportation
GA DE6NI
UT WOS:000370750200005
ER
PT J
AU Shaw, KA
Dunoski, BS
Mardis, NJ
Pacicca, DM
AF Shaw, Kenneth Aaron
Dunoski, Brian S.
Mardis, Neil J.
Pacicca, Donna M.
TI Combined posterolateral corner and acute anterior cruciate ligament
injuries in an adolescent cohort: a magnetic resonance imaging analysis
SO INTERNATIONAL ORTHOPAEDICS
LA English
DT Article
DE Anterior cruciate ligament; Posterolateral corner; Magnetic resonance
imaging
ID YOUNG ATHLETE; OPEN PHYSES; KNEE; RECONSTRUCTION; TEARS
AB Purpose Failure of a reconstructed anterior cruciate ligament (ACL) has significant morbidity in the paediatric and adolescent patient population. Untreated concomitant posterolateral corner (PLC) injury is an identified cause of failed ACL reconstruction; however, the injury pattern has yet to be defined for the paediatric population.
Methods Magnetic resonance imaging (MRI) studies of the knee performed between 1 January 2009 and 1 January 2013 were retrospectively reviewed. Imaging reports indicating an intra-substance injury of the ACL were reviewed, and all associated injured structures were recorded. Injury patterns were categorised by age, gender, physis status and associated injuries. Logistic regression and chi-square analyses compared ACL disruptions with and without concomitant PLC injuries.
Results One hundred and twenty-eight patients (74 boys and 54 girls, average age 15.27 years) sustained an ACL disruption. Concomitant injury to the PLC was seen in 13.3 % of injuries. Associated PLC injuries were significantly associated with lateral meniscus injury and Segond fractures. Lateral meniscus injury was predictive of PLC injury (p= 0.05) upon logistic regression analysis.
Conclusion Concomitant PLC injuries were found in 13.3 % of all ACL disruptions on MRI analysis. Lateral meniscus injuries associated with an ACL disruption were predictive of concomitant PLC injury. Combined injury of the ACL and lateral meniscus should prompt close scrutiny to PLC structures.
C1 [Shaw, Kenneth Aaron] Dwight D Eisenhower Army Med Ctr, Dept Orthopaed Surg, 300 East Hosp Rd, Ft Gordon, GA 30905 USA.
[Dunoski, Brian S.; Mardis, Neil J.] Childrens Mercy Hosp, Dept Radiol, Kansas City, MO 64108 USA.
[Pacicca, Donna M.] Childrens Mercy Hosp, Div Orthopaed Surg, Kansas City, MO 64108 USA.
RP Shaw, KA (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Orthopaed Surg, 300 East Hosp Rd, Ft Gordon, GA 30905 USA.
EM shaw.aaron82@gmail.com
OI Shaw, Kenneth/0000-0002-3553-2889
NR 20
TC 1
Z9 1
U1 1
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0341-2695
EI 1432-5195
J9 INT ORTHOP
JI Int. Orthop.
PD MAR
PY 2016
VL 40
IS 3
BP 555
EP 560
DI 10.1007/s00264-015-3026-x
PG 6
WC Orthopedics
SC Orthopedics
GA DF1FM
UT WOS:000371084600019
PM 26537394
ER
PT J
AU Hire, JM
Jacobs, JM
Bundy, JV
DeVine, JG
AF Hire, Justin M.
Jacobs, Jeremy M.
Bundy, Justin V.
DeVine, John G.
TI Modified Bohlman technique Response
SO JOURNAL OF NEUROSURGERY-SPINE
LA English
DT Letter
C1 [Hire, Justin M.; Jacobs, Jeremy M.] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA USA.
[Bundy, Justin V.] Doctors Hosp, Augusta Orthoped & Sports Med Specialists, Augusta, GA USA.
[DeVine, John G.] Georgia Regents Univ, Augusta Hosp Syst, Augusta, GA USA.
RP Hire, JM (reprint author), Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC NEUROLOGICAL SURGEONS
PI ROLLING MEADOWS
PA 5550 MEADOWBROOK DRIVE, ROLLING MEADOWS, IL 60008 USA
SN 1547-5654
EI 1547-5646
J9 J NEUROSURG-SPINE
JI J. Neurosurg.-Spine
PD MAR
PY 2016
VL 24
IS 3
BP 519
EP 519
PG 1
WC Clinical Neurology; Surgery
SC Neurosciences & Neurology; Surgery
GA DE8VT
UT WOS:000370915500032
PM 27358968
ER
PT J
AU Burgess, E
AF Burgess, Edwin
TI Court-Martial: How Military Justice Has Shaped America from the
Revolution to 9/11 and Beyond.
SO LIBRARY JOURNAL
LA English
DT Book Review
C1 [Burgess, Edwin] US Army Combined Arms Res Lib, Ft Leavenworth, KS USA.
RP Burgess, E (reprint author), US Army Combined Arms Res Lib, Ft Leavenworth, KS USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU REED BUSINESS INFORMATION
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA
SN 0363-0277
J9 LIBR J
JI Libr. J.
PD MAR 1
PY 2016
VL 141
IS 4
BP 108
EP 108
PG 1
WC Information Science & Library Science
SC Information Science & Library Science
GA DF1NB
UT WOS:000371105400156
ER
PT J
AU Burgess, E
AF Burgess, Edwin
TI So Close to Home: A True Story of an American Family's Fight for
Survival During World War II.
SO LIBRARY JOURNAL
LA English
DT Book Review
C1 [Burgess, Edwin] US Army Combined Arms Res Lib, Ft Leavenworth, KS USA.
RP Burgess, E (reprint author), US Army Combined Arms Res Lib, Ft Leavenworth, KS USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU REED BUSINESS INFORMATION
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA
SN 0363-0277
J9 LIBR J
JI Libr. J.
PD MAR 1
PY 2016
VL 141
IS 4
BP 110
EP 110
PG 1
WC Information Science & Library Science
SC Information Science & Library Science
GA DF1NB
UT WOS:000371105400164
ER
PT J
AU Brum, JR
Ignacio-Espinoza, JC
Kim, EH
Trubl, G
Jones, RM
Roux, S
VerBerkmoes, NC
Rich, VI
Sullivan, MB
AF Brum, Jennifer R.
Ignacio-Espinoza, J. Cesar
Kim, Eun-Hae
Trubl, Gareth
Jones, Robert M.
Roux, Simon
VerBerkmoes, Nathan C.
Rich, Virginia I.
Sullivan, Matthew B.
TI Illuminating structural proteins in viral "dark matter" with
metaproteomics
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE viruses; marine; proteins
ID SHOTGUN PROTEOMICS; OCEAN; VIRUSES; BACTERIOPHAGES; IDENTIFICATION;
GENOME; ENVIRONMENTS; COMMUNITIES; DISCOVERY; SOFTWARE
AB Viruses are ecologically important, yet environmental virology is limited by dominance of unannotated genomic sequences representing taxonomic and functional "viral dark matter." Although recent analytical advances are rapidly improving taxonomic annotations, identifying functional darkmatter remains problematic. Here, we apply paired metaproteomics and dsDNA-targeted metagenomics to identify 1,875 virion-associated proteins from the ocean. Over one-half of these proteins were newly functionally annotated and represent abundant and widespread viral metagenome-derived protein clusters (PCs). One primarily unannotated PC dominated the dataset, but structural modeling and genomic context identified this PC as a previously unidentified capsid protein from multiple uncultivated tailed virus families. Furthermore, four of the five most abundant PCs in the metaproteome represent capsid proteins containing the HK97-like protein fold previously found in many viruses that infect all three domains of life. The dominance of these proteins within our dataset, as well as their global distribution throughout the world's oceans and seas, supports prior hypotheses that this HK97-like protein fold is the most abundant biological structure on Earth. Together, these culture-independent analyses improve virion-associated protein annotations, facilitate the investigation of proteins within natural viral communities, and offer a high-throughput means of illuminating functional viral dark matter.
C1 [Brum, Jennifer R.; Roux, Simon; Sullivan, Matthew B.] Univ Arizona, Dept Ecol & Evolutionary Biol, Tucson, AZ 85721 USA.
[Ignacio-Espinoza, J. Cesar; Sullivan, Matthew B.] Univ Arizona, Dept Mol & Cellular Biol, Tucson, AZ 85721 USA.
[Kim, Eun-Hae; Trubl, Gareth; Jones, Robert M.; Rich, Virginia I.; Sullivan, Matthew B.] Univ Arizona, Dept Soil Water & Environm Sci, Tucson, AZ 85721 USA.
[VerBerkmoes, Nathan C.] Oak Ridge Natl Lab, Chem Sci Div, Oak Ridge, TN 37831 USA.
[Brum, Jennifer R.; Trubl, Gareth; Roux, Simon; Rich, Virginia I.; Sullivan, Matthew B.] Ohio State Univ, Dept Microbiol, Columbus, OH 43210 USA.
[Brum, Jennifer R.; Trubl, Gareth; Roux, Simon; Rich, Virginia I.; Sullivan, Matthew B.] Ohio State Univ, Dept Civil Environm & Geodet Engn, Columbus, OH 43210 USA.
[Ignacio-Espinoza, J. Cesar] Univ So Calif, Dept Biol Sci, Los Angeles, CA 90089 USA.
[Kim, Eun-Hae] Roche Tissue Diagnost, Oro Valley, AZ 85755 USA.
[Jones, Robert M.] US Army, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA.
[VerBerkmoes, Nathan C.] Univ Texas El Paso, Dept Biol Sci, Border Biomed Res Ctr, El Paso, TX 79968 USA.
RP Sullivan, MB (reprint author), Univ Arizona, Dept Ecol & Evolutionary Biol, Tucson, AZ 85721 USA.; Sullivan, MB (reprint author), Univ Arizona, Dept Mol & Cellular Biol, Tucson, AZ 85721 USA.; Rich, VI; Sullivan, MB (reprint author), Univ Arizona, Dept Soil Water & Environm Sci, Tucson, AZ 85721 USA.; Rich, VI; Sullivan, MB (reprint author), Ohio State Univ, Dept Microbiol, Columbus, OH 43210 USA.; Rich, VI; Sullivan, MB (reprint author), Ohio State Univ, Dept Civil Environm & Geodet Engn, Columbus, OH 43210 USA.
EM virginia.isabel.rich@gmail.com; mbsulli@gmail.com
OI Trubl, Gareth/0000-0001-5008-1476; Ignacio Espinoza, J.
Cesar/0000-0001-9303-7504
FU University Information Technology Services Research Computing Group;
Arizona Research Laboratories Biotechnology Computing; Ford Foundation
Postdoctoral Fellowship; Gordon and Betty Moore Foundation [GBMF2631,
GBMF3790]; UA Ecosystem Genomics Institute through the UA Technology and
Research Initiative Fund; Water, Environmental and Energy Solutions
Initiative
FX We thank Bonnie Poulos for preparing viral concentrates, Genoscope for
viral metagenomic sequencing, members of Tucson Marine Phage Lab for
comments on the manuscript, and University Information Technology
Services Research Computing Group and the Arizona Research Laboratories
Biotechnology Computing for High-Performance Computing Cluster access
and support. We thank Kristen Corrier and Manesh Shah of University of
Tennessee/Oak Ridge National Laboratory for efforts in filter-aided
sample preparation (FASP) preparation of viral samples and MS analyses,
and aspects of proteome informatics, respectively. The four viral
concentrates were collected as part of exceptional commitment by
scientists and sponsors who made the Tara Oceans expedition possible
[full list in Brum et al. (6)]. Funding specific to this project was
provided by a Ford Foundation Postdoctoral Fellowship (to E.-H.K.), the
Gordon and Betty Moore Foundation through Grants GBMF2631 and GBMF3790
(to M.B.S.), and a grant to the UA Ecosystem Genomics Institute through
the UA Technology and Research Initiative Fund and the Water,
Environmental and Energy Solutions Initiative (to M.B.S. and V.I.R.).
This article is contribution 35 of the Tara Oceans Expedition 2009-2012.
NR 63
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Z9 3
U1 6
U2 19
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD MAR 1
PY 2016
VL 113
IS 9
BP 2436
EP 2441
DI 10.1073/pnas.1525139113
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DF2WG
UT WOS:000371204500049
PM 26884177
ER
PT J
AU Collier, ZA
Gust, KA
Gonzalez-Morales, B
Gong, P
Wilbanks, MS
Linkov, I
Perkins, EJ
AF Collier, Zachary A.
Gust, Kurt A.
Gonzalez-Morales, Benette
Gong, Ping
Wilbanks, Mitchell S.
Linkov, Igor
Perkins, Edward J.
TI A weight of evidence assessment approach for adverse outcome pathways
SO REGULATORY TOXICOLOGY AND PHARMACOLOGY
LA English
DT Article
DE Adverse outcome pathway; Weight of evidence; Quantitative AOP; Molecular
initiating event; Mode of action; Key event relationships; Bradford Hill
criteria
ID PROLIFERATOR-ACTIVATED RECEPTOR; GAMMA-AMINOBUTYRIC-ACID; BOBWHITE
COLINUS-VIRGINIANUS; BRADFORD-HILL CONSIDERATIONS; PALMITOYLTRANSFERASE
I GENE; NUCLEAR HORMONE-RECEPTORS; CEREBELLAR GRANULE CELLS; NORTHERN
BOBWHITE; OF-EVIDENCE; PPAR-ALPHA
AB The adverse outcome pathway (AOP) is a framework to mechanistically link molecular initiating events to adverse biological outcomes. From a regulatory perspective, it is of crucial importance to determine the confidence for the AOP in question as well as the quality of data available in supporting this evaluation. A weight of evidence approach has been proposed for this task, but many of the existing frameworks for weight of evidence evaluation are qualitative and there is not clear guidance regarding how weight of evidence should be calculated for an AOP. In this paper we advocate the use of a subject matter expertise driven approach for weight of evidence evaluation based on criteria and metrics related to data quality and the strength of causal linkages between key events. As a demonstration, we notionally determine weight of evidence scores for two AOPs: Non-competitive ionotropic GABA receptor antagonism leading to epileptic seizures, and Antagonist-binding and stabilization of a co-repressor to the peroxisome proliferator-activated receptor alpha (PPAR alpha) signaling complex ultimately causing starvation like weight loss. Published by Elsevier Ltd.
C1 [Collier, Zachary A.; Gust, Kurt A.; Gong, Ping; Wilbanks, Mitchell S.; Linkov, Igor; Perkins, Edward J.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA.
[Gonzalez-Morales, Benette] Univ Puerto Rico, Mayaguez, PR USA.
RP Collier, ZA (reprint author), 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM zac4nf@virginia.edu
RI Leite, Paulo Emilio/N-3443-2013
OI Leite, Paulo Emilio/0000-0002-1783-1228
FU US Army Environmental Quality/Installations (EQ/I) research program
FX This work was funded by the US Army Environmental Quality/Installations
(EQ/I) research program. Permission was granted by the Chief of
Engineers to publish this material. The views and opinions expressed in
this paper are those of the individual authors and not those of the U.S.
Army, or other sponsor organizations.
NR 102
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U1 2
U2 16
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0273-2300
EI 1096-0295
J9 REGUL TOXICOL PHARM
JI Regul. Toxicol. Pharmacol.
PD MAR
PY 2016
VL 75
BP 46
EP 57
DI 10.1016/j.yrtph.2015.12.014
PG 12
WC Medicine, Legal; Pharmacology & Pharmacy; Toxicology
SC Legal Medicine; Pharmacology & Pharmacy; Toxicology
GA DE5NF
UT WOS:000370677000006
PM 26724267
ER
PT J
AU Townsley, E
O'Connor, G
Cosgrove, C
Woda, M
Co, M
Thomas, SJ
Kalayanarooj, S
Yoon, IK
Nisalak, A
Srikiatkhachorn, A
Green, S
Stephens, HAF
Gostick, E
Price, DA
Carrington, M
Alter, G
McVicar, DW
Rothman, AL
Mathew, A
AF Townsley, E.
O'Connor, G.
Cosgrove, C.
Woda, M.
Co, M.
Thomas, S. J.
Kalayanarooj, S.
Yoon, I. -K.
Nisalak, A.
Srikiatkhachorn, A.
Green, S.
Stephens, H. A. F.
Gostick, E.
Price, D. A.
Carrington, M.
Alter, G.
McVicar, D. W.
Rothman, A. L.
Mathew, A.
TI Interaction of a dengue virus NS1-derived peptide with the inhibitory
receptor KIR3DL1 on natural killer cells
SO CLINICAL AND EXPERIMENTAL IMMUNOLOGY
LA English
DT Article
DE dengue; HLA; KIR; NK; pathogenesis
ID NK-CELLS; DISEASE SEVERITY; HLA-B; ETHNIC THAIS; T-CELLS;
ANTIBODY-RESPONSE; INFECTION; ASSOCIATIONS; RECOGNITION; CORRELATE
AB Killer immunoglobulin-like receptors (KIRs) interact with human leucocyte antigen (HLA) class I ligands and play a key role in the regulation and activation of NK cells. The functional importance of KIR-HLA interactions has been demonstrated for a number of chronic viral infections, but to date only a few studies have been performed in the context of acute self-limited viral infections. During our investigation of CD8(+) T cell responses to a conserved HLA-B57-restricted epitope derived from dengue virus (DENV) non-structural protein-1 (NS1), we observed substantial binding of the tetrameric complex to non-T/non-B lymphocytes in peripheral blood mononuclear cells (PBMC) from a long-standing clinical cohort in Thailand. We confirmed binding of the NS1 tetramer to CD56(dim) NK cells, which are known to express KIRs. Using depletion studies and KIR-transfected cell lines, we demonstrated further that the NS1 tetramer bound the inhibitory receptor KIR3DL1. Phenotypical analysis of PBMC from HLA-B57(+) subjects with acute DENV infection revealed marked activation of NS1 tetramer-binding natural killer (NK) cells around the time of defervescence in subjects with severe dengue disease. Collectively, our findings indicate that subsets of NK cells are activated relatively late in the course of acute DENV illness and reveal a possible role for specific KIR-HLA interactions in the modulation of disease outcomes.
C1 [Townsley, E.; Woda, M.; Co, M.; Srikiatkhachorn, A.; Green, S.; Mathew, A.] Univ Massachusetts, Med Ctr, Div Infect Dis & Immunol, Worcester, MA USA.
[O'Connor, G.; Carrington, M.; McVicar, D. W.] Leidos Biomed Res Inc, Frederick Natl Lab Canc Res, Canc & Inflammat Program, Expt Immunol Lab, Frederick, MD USA.
[Cosgrove, C.; Carrington, M.; Alter, G.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Ragon Inst MGH MIT & Harvard, Boston, MA USA.
[Thomas, S. J.] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Kalayanarooj, S.] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand.
[Yoon, I. -K.; Nisalak, A.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand.
[Stephens, H. A. F.] UCL, Ctr Nephrol & Anthony Nolan Trust, Royal Free Campus, London, England.
[Gostick, E.; Price, D. A.] Cardiff Univ, Sch Med, Inst Infect & Immun, Cardiff CF10 3AX, S Glam, Wales.
[Price, D. A.] NIAID, Human Immunol Sect, Vaccine Res Ctr, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
[Rothman, A. L.] Univ Rhode Isl, Inst Immunol & Informat, 825 Chalkstone Ave, Providence, RI 02908 USA.
RP Mathew, A (reprint author), Univ Massachusetts, Div Infect Dis & Immunol, Sch Med, S6-862,55 Lake Ave North, Worcester, MA 01655 USA.
EM anuja.mathew@umassmed.edu
RI Price, David/C-7876-2013
OI Price, David/0000-0001-9416-2737
FU National Institutes of Health (NIH) [P01 AI34533, U19 AI57319, R21
AI113479, P30 DK032520]; Frederick National Laboratory for Cancer
Research [HHSN261200800001E]; NIH, Frederick National Laboratory, Center
for Cancer Research
FX We thank the subjects who generously donated peripheral blood samples
for use in our studies, the NIAID Tetramer Core Facility for provision
of the B57-NS126-34 tetramer, Brenda Hartman for expert assistance with
graphics and Dr Suchitra Nimmannitya and staff at the Queen Sirikit
National Institute for Child Health, the Department of Virology, Armed
Forces Research Institute of Medical Sciences and the Department of
Transfusion Medicine, Siriraj Hospital, for patient recruitment, sample
collection and clinical, virological and HLA typing information. This
work was funded by the National Institutes of Health (NIH) via Grants
P01 AI34533, U19 AI57319 and R21 AI113479 with core support from NIH P30
DK032520 and federal funds from the Frederick National Laboratory for
Cancer Research under Contract No. HHSN261200800001E. Additional support
was provided by the Intramural Research Program of the NIH, Frederick
National Laboratory, Center for Cancer Research. The content of this
publication does not necessarily reflect the views or policies of the
Department of Health and Human Services, nor does mention of trade
names, commercial products or organizations imply endorsement by the US
Government. D. A. P. is a Wellcome Trust Senior Investigator.
NR 48
TC 2
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U1 0
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0009-9104
EI 1365-2249
J9 CLIN EXP IMMUNOL
JI Clin. Exp. Immunol.
PD MAR
PY 2016
VL 183
IS 3
BP 419
EP 430
DI 10.1111/cei.12722
PG 12
WC Immunology
SC Immunology
GA DD8NU
UT WOS:000370184600011
PM 26439909
ER
PT J
AU Cornwell, JFM
Higgins, ET
AF Cornwell, James F. M.
Higgins, E. Tory
TI Eager Feelings and Vigilant Reasons: Regulatory Focus Differences in
Judging Moral Wrongs
SO JOURNAL OF EXPERIMENTAL PSYCHOLOGY-GENERAL
LA English
DT Article
DE intuition; reasoning; regulatory focus; moral judgment
ID PREVENTION; AVOIDANCE; PROMOTION; JUDGMENTS; DISGUST; FIT; DECISIONS;
FOUNDATIONS; INFORMATION; PERFORMANCE
AB For over a decade, moral psychologists have been actively researching the processes underlying moral judgments that are made intuitively without reference to an action's concrete harms or injustice, such as the well-known case of nonprocreative, consensual incest. We suggest that the reason some judge such scenarios as wrong (using intuitive feelings) and others do not (using deliberative reasons) is due to an important motivational distinction. Consistent with this view, across 7 studies, we demonstrate that negative judgments of such moral scenarios are more intense when processed in the promotion focus compared to the prevention focus, and that this is due to differences in whether eager (intuitive feelings) versus vigilant (deliberative reasons) means are employed in judging these moral wrongs. By examining both boundary conditions and possible underlying mechanisms for regulatory focus differences in moral judgment intensity, we expand our understanding of the differences between promotion and prevention regarding how proscriptive judgments are processed, while integrating these differences with existing theories in moral psychology.
C1 [Cornwell, James F. M.] US Mil Acad, Dept Behav Sci & Leadership, 281 Thayer Hall, West Point, NY 10996 USA.
[Higgins, E. Tory] Columbia Univ, Dept Psychol, New York, NY 10027 USA.
RP Cornwell, JFM (reprint author), US Mil Acad, Dept Behav Sci & Leadership, 281 Thayer Hall, West Point, NY 10996 USA.
EM jamesfcornwell@gmail.com
FU National Science Foundation; National Institute of Mental Health [39429]
FX We thank John Jost for his helpful comments on an earlier version of
this article. We would also like to thank Serena De Stefani, Bradley
Swain, and Jay Kent for their assistance in coding participant essays.
This research was supported by the National Science Foundation in the
form of a Graduate Research Fellowship awarded to James Cornwell. It was
also supported by Grant 39429 from the National Institute of Mental
Health to E. Tory Higgins
NR 66
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U1 4
U2 24
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0096-3445
EI 1939-2222
J9 J EXP PSYCHOL GEN
JI J. Exp. Psychol.-Gen.
PD MAR
PY 2016
VL 145
IS 3
BP 338
EP 355
DI 10.1037/xge0000136
PG 18
WC Psychology, Experimental
SC Psychology
GA DE4TO
UT WOS:000370623400007
PM 26726912
ER
PT J
AU Kalantarnia, M
Chouinard, L
Foltz, S
AF Kalantarnia, Maryam
Chouinard, Luc
Foltz, Stuart
TI Objective Procedure for Optimization of Inspection and Testing
Strategies for Spillways
SO JOURNAL OF INFRASTRUCTURE SYSTEMS
LA English
DT Article
DE Spillway gate system; Unavailability; Inspection and testing;
Optimization; Flood; Load rejection; Software application
ID COST; RISK
AB The function of a spillway gate system is to control the flow of water through an opening for purposes such as flow regulation, flood control, emergency water release during load rejection, and dewatering for maintenance operations, or to remediate or respond to structural deficiencies. A growing problem for dam owners is the aging of such structures. As spillway systems age, more rigorous maintenance, inspection/testing, and repair/replacement of parts are required to ensure their long-term safe operation. Executing these measures may be very costly to dam owners and, if not conducted appropriately, may not have the desired effect on the reliability of the system. The first objective of this paper is to investigate the effect of inspection, testing, repair, and replacement strategies on the availability of spillway gate components. The second objective is to model the availability of the entire spillway gate system under flood and load rejection scenarios to determine the ability of the system as a whole to operate safely under emergency conditions. These two objectives are then used with cost optimization to develop recommendations on the type and frequency of inspections and tests for different types of spillway gate systems. A software application was developed to achieve the objectives by modeling the spillway gate components and system, determining component/system unavailability based on type and frequency of inspections/tests, and obtaining the optimum inspection/testing strategy. (C) 2015 American Society of Civil Engineers.
C1 [Kalantarnia, Maryam; Chouinard, Luc] McGill Univ, Montreal, PQ H3A 0G4, Canada.
[Foltz, Stuart] US Army, Corps Engineers, ERDC CERL, Chicago, IL 61826 USA.
RP Kalantarnia, M (reprint author), McGill Univ, Montreal, PQ H3A 0G4, Canada.
EM maryam.kalantarnia@mail.mcgill.ca
NR 29
TC 0
Z9 0
U1 3
U2 4
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 1076-0342
EI 1943-555X
J9 J INFRASTRUCT SYST
JI J. Infrastruct. Syst.
PD MAR
PY 2016
VL 22
IS 1
AR 04015011
DI 10.1061/(ASCE)IS.1943-555X.0000259
PG 12
WC Engineering, Civil
SC Engineering
GA DE1ZB
UT WOS:000370424500001
ER
PT J
AU Saunders, D
Lon, C
AF Saunders, David
Lon, Chanthap
TI Combination therapies for malaria are failing-what next?
SO LANCET INFECTIOUS DISEASES
LA English
DT Editorial Material
ID DIHYDROARTEMISININ-PIPERAQUINE FAILURE; CAMBODIA; ARTESUNATE; RESISTANCE
C1 [Saunders, David] US Army, Med Mat Dev Act, Ft Detrick, MD USA.
[Lon, Chanthap] US Army Med Component, Armed Forces Res Inst Med Sci, Phnom Penh, Cambodia.
RP Saunders, D (reprint author), US Army, Med Mat Dev Act, Ft Detrick, MD USA.
EM david.l.saunders.mil@mail.mil
NR 11
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Z9 2
U1 0
U2 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1473-3099
EI 1474-4457
J9 LANCET INFECT DIS
JI Lancet Infect. Dis.
PD MAR
PY 2016
VL 16
IS 3
BP 274
EP 275
DI 10.1016/S1473-3099(15)00525-3
PG 2
WC Infectious Diseases
SC Infectious Diseases
GA DE4FQ
UT WOS:000370585000008
PM 26774241
ER
PT J
AU Pinsker, JE
Kain, C
Keller, L
Rooks, VJ
AF Pinsker, Jordan E.
Kain, Conor
Keller, Laura
Rooks, Veronica J.
TI Vitamin D deficiency versus non-accidental trauma: comment on "Rickets
or abuse? A histologic comparison of rickets and child abuse-related
fractures"
SO FORENSIC SCIENCE MEDICINE AND PATHOLOGY
LA English
DT Letter
C1 [Pinsker, Jordan E.] William Sansum Diabet Ctr, 2219 Bath St, Santa Barbara, CA 93105 USA.
[Pinsker, Jordan E.; Kain, Conor; Keller, Laura; Rooks, Veronica J.] Tripler Army Med Ctr, Honolulu, HI 96859 USA.
RP Pinsker, JE (reprint author), William Sansum Diabet Ctr, 2219 Bath St, Santa Barbara, CA 93105 USA.; Pinsker, JE (reprint author), Tripler Army Med Ctr, Honolulu, HI 96859 USA.
EM jpinsker@sansum.org
OI Pinsker, Jordan/0000-0003-4080-9034
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U1 0
U2 5
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 1547-769X
EI 1556-2891
J9 FORENSIC SCI MED PAT
JI Forensic Sci. Med. Pathol.
PD MAR
PY 2016
VL 12
IS 1
BP 119
EP 120
DI 10.1007/s12024-015-9720-6
PG 2
WC Medicine, Legal; Pathology
SC Legal Medicine; Pathology
GA DD6ZK
UT WOS:000370073100021
PM 26438420
ER
PT J
AU Chung, KK
Rhie, RY
Lundy, JB
Cartotto, R
Henderson, E
Pressman, MA
Joe, VC
Aden, JK
Driscoll, IR
Faucher, LD
McDermid, RC
Mlcak, RP
Hickerson, WL
Jeng, JC
AF Chung, Kevin K.
Rhie, Ryan Y.
Lundy, Jonathan B.
Cartotto, Robert
Henderson, Elizabeth
Pressman, Melissa A.
Joe, Victor C.
Aden, James K.
Driscoll, Ian R.
Faucher, Lee D.
McDermid, Robert C.
Mlcak, Ronald P.
Hickerson, William L.
Jeng, James C.
TI A Survey of Mechanical Ventilator Practices Across Burn Centers in North
America
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
ID RESPIRATORY-DISTRESS-SYNDROME; ACUTE LUNG INJURY; FREQUENCY PERCUSSIVE
VENTILATION; RANDOMIZED CONTROLLED-TRIAL; END-EXPIRATORY PRESSURE;
INHALATION INJURY; OSCILLATORY VENTILATION; TIDAL VOLUMES; TRACHEOSTOMY;
METAANALYSIS
AB Burn injury introduces unique clinical challenges that make it difficult to extrapolate mechanical ventilator (MV) practices designed for the management of general critical care patients to the burn population. We hypothesize that no consensus exists among North American burn centers with regard to optimal ventilator practices. The purpose of this study is to examine various MV practice patterns in the burn population and to identify potential opportunities for future research. A researcher designed, 24-item survey was sent electronically to 129 burn centers. The (2), Fisher's exact, and Cochran-Mantel-Haenszel tests were used to determine if there were significant differences in practice patterns. We analyzed 46 questionnaires for a 36% response rate. More than 95% of the burn centers reported greater than 100 annual admissions. Pressure support and volume assist control were the most common initial MV modes used with or without inhalation injury. In the setting of Berlin defined mild acute respiratory distress syndrome (ARDS), ARDSNet protocol and optimal positive end-expiratory pressure were the top ventilator choices, along with fluid restriction/diuresis as a nonventilator adjunct. For severe ARDS, airway pressure release ventilation and neuromuscular blockade were the most popular. The most frequently reported time frame for mechanical ventilation before tracheostomy was 2 weeks (25 of 45, 55%); however, all respondents reported in the affirmative that there are certain clinical situations where early tracheostomy is warranted. Wide variations in clinical practice exist among North American burn centers. No single ventilator mode or adjunct prevails in the management of burn patients regardless of pulmonary insult. Movement toward American Burn Association-supported, multicenter studies to determine best practices and guidelines for ventilator management in burn patients is prudent in light of these findings.
C1 [Chung, Kevin K.; Rhie, Ryan Y.; Lundy, Jonathan B.; Aden, James K.; Driscoll, Ian R.] US Army, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.
[Chung, Kevin K.; Lundy, Jonathan B.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Cartotto, Robert] Sunnybrook Hlth Sci Ctr, Toronto, ON M4N 3M5, Canada.
[Henderson, Elizabeth] Massachusetts Gen Hosp, Boston, MA 02114 USA.
[Pressman, Melissa A.] Arizona Burn Ctr, Phoenix, AZ USA.
[Joe, Victor C.] Univ Calif Irvine, Reg Burn Ctr, Orange, CA USA.
[Faucher, Lee D.] Univ Wisconsin Hosp, Madison, WI USA.
[McDermid, Robert C.] Univ Alberta, Edmonton, AB, Canada.
[Mlcak, Ronald P.] Shriners Hosp Children, Galveston, TX 77550 USA.
[Hickerson, William L.] Memphis Burn Ctr, Memphis, TN USA.
[Jeng, James C.] Mt Sinai Beth Israel Med Ctr, New York, NY USA.
RP Chung, KK (reprint author), US Army, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.
EM Kevin.k.chung.mil@mail.mil
FU American Burn Association
FX This project was commissioned by the Organization and Delivery of Burn
Care Committee and funded in part by the American Burn Association.
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PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD MAR-APR
PY 2016
VL 37
IS 2
BP E131
EP E139
DI 10.1097/BCR.0000000000000270
PG 9
WC Emergency Medicine; Dermatology; Surgery
SC Emergency Medicine; Dermatology; Surgery
GA DD4AZ
UT WOS:000369866100005
PM 26135527
ER
PT J
AU Williams, JF
Lundy, JB
Chung, KK
Chan, RK
King, BT
Renz, EM
Cancio, LC
AF Williams, James F.
Lundy, Jonathan B.
Chung, Kevin K.
Chan, Rodney K.
King, Booker T.
Renz, Evan M.
Cancio, Leopoldo C.
TI Traumatic Injuries Incidental to Hydraulic Well Fracturing: A Case
Series
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
C1 [Williams, James F.; Lundy, Jonathan B.; Chung, Kevin K.; Chan, Rodney K.; King, Booker T.; Renz, Evan M.; Cancio, Leopoldo C.] US Army, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.
[Chung, Kevin K.; Renz, Evan M.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Cancio, Leopoldo C.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.
RP Chung, KK (reprint author), US Army, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.
FU Clinical Trials Task Area, U.S. Army Institute of Surgical Research, Ft
Sam Houston, Texas
FX This study was supported by the Clinical Trials Task Area, U.S. Army
Institute of Surgical Research, Ft Sam Houston, Texas. The authors would
like to thank Otilia Sanchez, who provided medical writing services on
behalf of the U.S. Army Institute of Surgical Research.
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PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD MAR-APR
PY 2016
VL 37
IS 2
BP E188
EP E192
DI 10.1097/BCR.0000000000000219
PG 5
WC Emergency Medicine; Dermatology; Surgery
SC Emergency Medicine; Dermatology; Surgery
GA DD4AZ
UT WOS:000369866100013
PM 25423442
ER
PT J
AU Araujo, M
Gunnemann, S
Papadimitriou, S
Faloutsos, C
Basu, P
Swami, A
Papalexakis, E
Koutra, D
AF Araujo, Miguel
Guennemann, Stephan
Papadimitriou, Spiros
Faloutsos, Christos
Basu, Prithwish
Swami, Ananthram
Papalexakis, Evangelos E.
Koutra, Danai
TI Discovery of "comet" communities in temporal and labeled graphs COM2
SO KNOWLEDGE AND INFORMATION SYSTEMS
LA English
DT Article
DE Community detection; Temporal data; Edge labels; Tensor decomposition
ID DECOMPOSITION; NETWORKS
AB While the analysis of unlabeled networks has been studied extensively in the past, finding patterns in different kinds of labeled graphs is still an open challenge. Given a large edge-labeled network, e.g., a time-evolving network, how can we find interesting patterns? We propose Com , a novel, fast and incremental tensor analysis approach which can discover communities appearing over subsets of the labels. The method is (a) scalable, being linear on the input size, (b) general, (c) needs no user-defined parameters and (d) effective, returning results that agree with intuition. We apply our method to real datasets, including a phone call network, a computer-traffic network and a flight information network. The phone call network consists of 4 million mobile users, with 51 million edges (phone calls), over 14 days, while the flights dataset consists of 7733 airports and 5995 airline companies flying 67,663 different routes. We show that Com spots intuitive patterns regarding edge labels that carry temporal or other discrete information. Our findings include large "star"-like patterns, near-bipartite cores, as well as tiny groups (five users), calling each other hundreds of times within a few days. We also show that we are able to automatically identify competing airline companies.
C1 [Araujo, Miguel; Guennemann, Stephan; Faloutsos, Christos; Papalexakis, Evangelos E.; Koutra, Danai] Carnegie Mellon Univ, iLab, Pittsburgh, PA 15213 USA.
[Araujo, Miguel; Guennemann, Stephan; Faloutsos, Christos; Papalexakis, Evangelos E.; Koutra, Danai] Carnegie Mellon Univ, Sch Comp Sci, Pittsburgh, PA 15213 USA.
[Araujo, Miguel] Univ Porto, CRACS INESC TEC, P-4100 Oporto, Portugal.
[Papadimitriou, Spiros] Rutgers State Univ, New Brunswick, NJ 08903 USA.
[Basu, Prithwish] Raytheon BBN Technol, Cambridge, MA USA.
[Swami, Ananthram] Army Res Lab, Adelphi, MD USA.
[Araujo, Miguel] Univ Porto, Fac Ciencias, Dept Ciencia Comp, P-4100 Oporto, Portugal.
RP Araujo, M (reprint author), Carnegie Mellon Univ, iLab, Pittsburgh, PA 15213 USA.
EM maraujo@cs.cmu.edu
OI Araujo, Miguel/0000-0003-2929-7218
FU National Science Foundation [IIS-1247489, IIS-1217559]; Defense Threat
Reduction Agency; Army Research Laboratory; US Army Research Office
(ARO); Defense Advanced Research Projects Agency (DARPA)
[W911NF-11-C-0088]; Google Focused Research Award; Fundacao para a
Ciencia e a Tecnologia (Portuguese Foundation for Science and
Technology) through the Carnegie Mellon Portugal Program
[SFRH/BD/52362/2013]; ERDF; FCT through the COMPETE Programme
[FCOMP-01-0124-FEDER-037281]; German Academic Exchange Service (DAAD);
[HDTRA1-10-1-0120]; [W911NF-09-2-0053]
FX This material is based upon work supported by the National Science
Foundation under Grant Nos. IIS-1247489 and IIS-1217559. Research was
sponsored by the Defense Threat Reduction Agency and was accomplished
under contract No. HDTRA1-10-1-0120 and also sponsored by the Army
Research Laboratory and was accomplished under Cooperative Agreement No.
W911NF-09-2-0053. Additional funding was provided by the US Army
Research Office (ARO) and Defense Advanced Research Projects Agency
(DARPA) under Contract No. W911NF-11-C-0088. This work is also partially
supported by a Google Focused Research Award, by the Fundacao para a
Ciencia e a Tecnologia (Portuguese Foundation for Science and
Technology) through the Carnegie Mellon Portugal Program under Grant
SFRH/BD/52362/2013, by ERDF and FCT through the COMPETE Programme within
project FCOMP-01-0124-FEDER-037281 and by a fellowship within the
postdoc program of the German Academic Exchange Service (DAAD). Any
opinions, findings and conclusions or recommendations expressed in this
material are those of the author(s) and do not necessarily reflect the
views of the National Science Foundation, DARPA or other funding
parties. The US Government is authorized to reproduce and distribute
reprints for Government purposes notwithstanding any copyright notation
here on.
NR 40
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PU SPRINGER LONDON LTD
PI LONDON
PA 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND
SN 0219-1377
EI 0219-3116
J9 KNOWL INF SYST
JI Knowl. Inf. Syst.
PD MAR
PY 2016
VL 46
IS 3
BP 657
EP 677
DI 10.1007/s10115-015-0847-2
PG 21
WC Computer Science, Artificial Intelligence; Computer Science, Information
Systems
SC Computer Science
GA DD4SB
UT WOS:000369911800007
ER
PT J
AU Jia, GF
Taflanidis, AA
Nadal-Caraballo, NC
Melby, JA
Kennedy, AB
Smith, JM
AF Jia, Gaofeng
Taflanidis, Alexandros A.
Nadal-Caraballo, Norberto C.
Melby, Jeffrey A.
Kennedy, Andrew B.
Smith, Jane M.
TI Surrogate modeling for peak or time-dependent storm surge prediction
over an extended coastal region using an existing database of synthetic
storms
SO NATURAL HAZARDS
LA English
DT Article
DE Surrogate model; Kriging; Principal component analysis; Time-dependent
output; Storm surge; High-fidelity hurricane surge model
ID RESPONSE FUNCTION-APPROACH; HAZARD ASSESSMENT; RISK-ASSESSMENT; WAVE;
ATTRIBUTES; SIMULATION; HURRICANES; WIND
AB This paper investigates the development of a kriging surrogate model for storm surge prediction utilizing an existing database of high-fidelity, synthetic storms. This surrogate model (metamodel) provides a fast-to-compute mathematical approximation to the input/output relationship of the computationally expensive simulation model that created this database. The implementation is considered over a large coastal region composed of nearshore nodes (locations where storm surge is predicted) and further examines the ability to provide time-series forecasting. This setting creates a high-dimensional output (over a few thousand surge responses) for the surrogate model with anticipated high spatial/temporal correlation. Kriging is considered as a surrogate model, and special attention is given to the appropriate parameterization of the synthetic storms, based on the characteristics of the given database, to determine the input for the metamodel formulation. Principal component analysis (PCA) is integrated in this formulation as a dimension reduction technique to improve computational efficiency, as well as to provide accurate and continuous predictions for time-dependent outputs without the need to introduce time averaging in the time-series forecasting. This is established by leveraging the aforementioned correlation characteristics within the initial database. A range of different implementation choices is examined within the integrated kriging/PCA setting, such as the development of single or multiple metamodels for the different outputs. The metamodel accuracy for inland nodes that have remained dry in some of the storms in the initial database is also examined. The performance of the surrogate modeling approach is evaluated through a case study, utilizing a database of 446 synthetic storms for the Gulf of Mexico (Louisiana coast). The output considered includes time histories for 30 locations over a period of 45.5 h with 92 uniform time steps, as well as peak responses over a grid of 545,635 nearshore nodes. High accuracy and computational efficiency are observed for the proposed implementation, whereas including the prediction error statistics provides estimations with significant safety margins.
C1 [Jia, Gaofeng; Taflanidis, Alexandros A.; Kennedy, Andrew B.] Univ Notre Dame, Dept Civil & Environm Engn & Earth Sci, 156 Fitzpatrick Hall, Notre Dame, IN 46556 USA.
[Nadal-Caraballo, Norberto C.; Melby, Jeffrey A.; Smith, Jane M.] United States Army Corps Engineers, Ctr Res & Dev, Vicksburg, MS 39180 USA.
RP Taflanidis, AA (reprint author), Univ Notre Dame, Dept Civil & Environm Engn & Earth Sci, 156 Fitzpatrick Hall, Notre Dame, IN 46556 USA.
EM a.taflanidis@nd.edu
RI Kennedy, Andrew/E-4746-2011
OI Kennedy, Andrew/0000-0002-7254-1346
FU US Army Corps of Engineers, Engineer Research and Development Center,
Coastal and Hydraulics Laboratory, Flood and Coastal Systems RD Program
FX This work has been done under contract with the US Army Corps of
Engineers, Engineer Research and Development Center, Coastal and
Hydraulics Laboratory, Flood and Coastal Systems R&D Program. This
support is gratefully acknowledged.
NR 45
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U2 12
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0921-030X
EI 1573-0840
J9 NAT HAZARDS
JI Nat. Hazards
PD MAR
PY 2016
VL 81
IS 2
BP 909
EP 938
DI 10.1007/s11069-015-2111-1
PG 30
WC Geosciences, Multidisciplinary; Meteorology & Atmospheric Sciences;
Water Resources
SC Geology; Meteorology & Atmospheric Sciences; Water Resources
GA DD6XT
UT WOS:000370068700011
ER
PT J
AU Qu, HB
Costache, MC
Inan, S
Cowan, A
Devore, D
Ducheyne, P
AF Qu, Haibo
Costache, Marius C.
Inan, Saadet
Cowan, Alan
Devore, David
Ducheyne, Paul
TI Local, Controlled Delivery of Local Anesthetics In Vivo from Polymer -
Xerogel Composites
SO PHARMACEUTICAL RESEARCH
LA English
DT Article
DE composite; controlled release; local anesthetic; sol-gel
ID REGIONAL NERVE BLOCKADE; CONTROLLED-RELEASE; POSTOPERATIVE PAIN;
INCISIONAL PAIN; DRUG-RELEASE; RAT MODEL; SOL-GEL; BUPIVACAINE;
POLYCARBONATES; MICROSPHERES
AB Polymer-xerogel composite materials have been introduced to better optimize local anesthetics release kinetics for the pain management. In a previous study, it was shown that by adjusting various compositional and nano-structural properties of both inorganic xerogels and polymers, zero-order release kinetics over 7 days can be achieved in vitro. In this study, in vitro release properties are confirmed in vivo using a model that tests for actual functionality of the released local anesthetics.
Composite materials made with tyrosine-polyethylene glycol(PEG)-derived poly(ether carbonate) copolymers and silica-based sol-gel (xerogel) were synthesized. The in vivo release from the composite controlled release materials was demonstrated by local anesthetics delivery in a rat incisional pain model.
The tactile allodynia resulting from incision was significantly attenuated in rats receiving drug-containing composites compared with the control and sham groups for the duration during which natural healing had not yet taken place. The concentration of drug (bupivacaine) in blood is dose dependent and maintained stable up to 120 h post-surgery, the longest time point measured.
These in vivo studies show that polymer-xerogel composite materials with controlled release properties represent a promising class of controlled release materials for pain management.
C1 [Qu, Haibo; Ducheyne, Paul] Univ Penn, Dept Bioengn, Ctr Bioact Mat & Tissue Engn, Philadelphia, PA 19104 USA.
[Costache, Marius C.] Rutgers State Univ, New Jersey Ctr Biomat, Piscataway, NJ 08854 USA.
[Inan, Saadet; Cowan, Alan] Temple Univ, Dept Pharmacol, Philadelphia, PA 19140 USA.
[Devore, David] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
RP Ducheyne, P (reprint author), Univ Penn, Dept Bioengn, Ctr Bioact Mat & Tissue Engn, Philadelphia, PA 19104 USA.
EM ducheyne@seas.upenn.edu
FU U.S. Army [W81XWH-07-1-0438]
FX This work was supported by U.S. Army contract #W81XWH-07-1-0438. The
U.S. Army Medical Research Acquisition Activity, 820 Chandler Street,
Fort Detrick MD 21702-5014 is the awarding and administering acquisition
office. The content of the manuscript does not necessarily reflect the
position or the policy of the Government, and no official endorsement
should be inferred.
NR 37
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U2 22
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0724-8741
EI 1573-904X
J9 PHARM RES-DORDR
JI Pharm. Res.
PD MAR
PY 2016
VL 33
IS 3
BP 729
EP 738
DI 10.1007/s11095-015-1822-z
PG 10
WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy
SC Chemistry; Pharmacology & Pharmacy
GA DD5EV
UT WOS:000369946400015
PM 26555665
ER
PT J
AU Guo, ZR
Casem, D
Hudspeth, M
Nie, X
Sun, JZ
Chen, WN
AF Guo, Zherui
Casem, Daniel
Hudspeth, Matthew
Nie, Xu
Sun, Jianzhuo
Chen, Weinong
TI Transverse compression of two high-performance ballistic fibers
SO TEXTILE RESEARCH JOURNAL
LA English
DT Article
DE transverse compression; ballistic fiber; polymer; Kevlar; Dyneema; gold
ID MECHANICAL-PROPERTIES; SINGLE-FIBER; PPTA FIBERS
AB The method for determining the transverse mechanical response of Kevlar (R) KM2 and Dyneema (R) SK76 fibers was improved upon from previous versions of single fiber compression tests. Two fibers were laid parallel and compressed between two tool steel platens. The new experimental setup ensures that the individual fibers are being compressed evenly along the length and that the platens are parallel during compression. Nominal stress-strain curves were obtained for quasi-static loading of both types of fibers. To evaluate the rate effects on the transverse behavior, high-rate transverse compression experiments were also performed using a miniature Kolsky bar loading on single-fiber specimens to obtain the corresponding stress-strain response of these high performance fibers at high rates of deformation.
C1 [Guo, Zherui; Hudspeth, Matthew; Sun, Jianzhuo] Purdue Univ, Sch Aeronaut & Astronaut, 2116 McCormick Rd, W Lafayette, IN 47906 USA.
[Casem, Daniel] US Army, Res Lab, Aberdeen Proving Ground, MD USA.
[Nie, Xu] Univ N Texas, Dept Mech Engn, Denton, TX 76203 USA.
[Chen, Weinong] Purdue Univ, Sch Mat Engn, 2116 McCormick Rd, W Lafayette, IN 47906 USA.
RP Guo, ZR (reprint author), Purdue Univ, Sch Aeronaut & Astronaut, 2116 McCormick Rd, W Lafayette, IN 47906 USA.; Guo, ZR (reprint author), Purdue Univ, 2116 McCormick Rd, W Lafayette, IN 47906 USA.
EM gzherui@purdue.edu
FU Johns Hopkins University ARL MEDE Program's Polymer CMRG
FX This work was partially supported by the Johns Hopkins University ARL
MEDE Program's Polymer CMRG.
NR 10
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U1 4
U2 14
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0040-5175
EI 1746-7748
J9 TEXT RES J
JI Text. Res. J.
PD MAR
PY 2016
VL 86
IS 5
BP 502
EP 511
DI 10.1177/0040517515592814
PG 10
WC Materials Science, Textiles
SC Materials Science
GA DD6PV
UT WOS:000370047000006
ER
PT J
AU Lu, XCM
Shear, DA
Deng-Bryant, Y
Leung, LY
Wei, G
Chen, ZY
Tortella, FC
AF Lu, Xi-Chun May
Shear, Deborah A.
Deng-Bryant, Ying
Leung, Lai Yee
Wei, Guo
Chen, Zhiyong
Tortella, Frank C.
TI Comprehensive Evaluation of Neuroprotection Achieved by Extended
Selective Brain Cooling Therapy in a Rat Model of Penetrating
Ballistic-Like Brain Injury
SO THERAPEUTIC HYPOTHERMIA AND TEMPERATURE MANAGEMENT
LA English
DT Article
ID NONDISRUPTIVE AXONAL INJURY; RANDOMIZED CONTROLLED-TRIAL; POSTTRAUMATIC
HYPOTHERMIA; MODERATE HYPOTHERMIA; INTRACEREBRAL HEMORRHAGE; STATUS
EPILEPTICUS; MILD HYPOTHERMIA; INFLAMMATION; SEIZURES; TRAUMA
AB Brain hypothermia has been considered as a promising alternative to whole-body hypothermia in treating acute neurological disease, for example, traumatic brain injury. Previously, we demonstrated that 2-hours selective brain cooling (SBC) effectively mitigated acute (<= 24 hours postinjury) neurophysiological dysfunction induced by a penetrating ballistic-like brain injury (PBBI) in rats. This study evaluated neuroprotective effects of extended SBC (4 or 8 hours in duration) on sub-acute secondary injuries between 3 and 21 days postinjury (DPI). SBC (34 degrees C) was achieved via extraluminal cooling of rats' bilateral common carotid arteries (CCA). Depending on the experimental design, SBC was introduced either immediately or with a 2- or 4-hour delay after PBBI and maintained for 4 or 8 hours. Neuroprotective effects of SBC were evaluated by measuring brain lesion volume, axonal injury, neuroinflammation, motor and cognitive functions, and post-traumatic seizures. Compared to untreated PBBI animals, 4 or 8 hours SBC treatment initiated immediately following PBBI produced comparable neuroprotective benefits against PBBI-induced early histopathology at 3 DPI as evidenced by significant reductions in brain lesion volume, axonal pathology (beta-amyloid precursor protein staining), neuroinflammation (glial fibrillary acetic protein stained-activated astrocytes and rat major histocompatibility complex class I stained activated microglial cell), and post-traumatic nonconvulsive seizures. In the later phase of the injury (7-21 DPI), significant improvement on motor function (rotarod test) was observed under most SBC protocols, including the 2-hour delay in SBC initiation. However, SBC treatment failed to improve cognitive performance (Morris water maze test) measured 13-17 DPI. The protective effects of SBC on delayed axonal injury (silver staining) were evident out to 14 DPI. In conclusion, the CCA cooling method of SBC produced neuroprotection measured across multiple domains that were evident days/weeks beyond the cooling duration and in the absence of overt adverse effects. These proof-of-concept results suggest that SBC may provide an attractive neuroprotective approach for clinical considerations.
C1 [Lu, Xi-Chun May; Shear, Deborah A.; Deng-Bryant, Ying; Leung, Lai Yee; Wei, Guo; Chen, Zhiyong; Tortella, Frank C.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Branch Brain Trauma Neuroprotect & Neurorestorat, 503 Robert Grant Ave, Silver Spring, MD USA.
RP Lu, XCM (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Branch Brain Trauma Neuroprotect & Neurorestorat, 503 Robert Grant Ave, Silver Spring, MD USA.
EM xi-chun.m.lu.civ@mail.mil
FU U.S. Army Medical Research and Material Command, Combat Casualty Care
Research Program
FX This work was supported by funding provided by the U.S. Army Medical
Research and Material Command, Combat Casualty Care Research Program. We
would like to thank Ms. Xiaofang Yang for her excellent technical
support on these experiments.
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U2 7
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2153-7658
EI 2153-7933
J9 THER HYPOTHERMIA TEM
JI Ther. Hypothermia Temp. Manag.
PD MAR 1
PY 2016
VL 6
IS 1
BP 30
EP 39
DI 10.1089/ther.2015.0017
PG 10
WC Critical Care Medicine
SC General & Internal Medicine
GA DD5NV
UT WOS:000369971800007
PM 26684246
ER
PT J
AU Krebs, SJ
Ananworanich, J
AF Krebs, Shelly J.
Ananworanich, Jintanat
TI Immune activation during acute HIV infection and the impact of early
antiretroviral therapy
SO CURRENT OPINION IN HIV AND AIDS
LA English
DT Review
DE acute infection; antiretroviral therapy; HIV; immune activation;
inflammation
ID T-CELL-ACTIVATION; VIRUS TYPE-1 INFECTION; DISEASE PROGRESSION; PREDICT
MORTALITY; RHESUS MACAQUES; SIV INFECTION; SET-POINT; C VIRUS; VIREMIA;
TH17
AB Purpose of reviewThe purpose of this review is to outline recent data pertaining to mechanisms of immune activation in acute infection and describe new developments that seek to determine if early antiretroviral treatment can mitigate chronic immune activation.Recent findingsFollowing the detection of HIV RNA, highly activated CD8(+) T cells expand and peak approximately 2 weeks following peak viral load whereas levels of proinflammatory soluble markers coincide with a rise in viral load. Immune activation during acute infection is driven by many factors including pyroptosis, replicative capacity of the infecting virus, and loss of Th17 cells within the gut. Early antiretroviral therapy (ART), particularly if initiated in Fiebig I (HIV IgM-), preserved mucosal CD4(+) T cells, possibly preventing the release of microbial products associated with immune activation. Viral reservoirs were restricted by the early initiation of ART, and heightened systemic immune activation was partially prevented compared with chronic HIV infection. A strong correlation was found between the size of the viral reservoir and cellular immune activation.SummaryThe timing of immune activation during acute infection occurs shortly after exposure. Recent studies demonstrated that ART mitigates inflammatory responses, preserves CD4(+) T cells, and limits reservoir seeding if provided early in acute HIV infection.
C1 [Krebs, Shelly J.; Ananworanich, Jintanat] Walter Reed Army Inst Res, US Mil HIV Res Program, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
[Krebs, Shelly J.; Ananworanich, Jintanat] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
RP Krebs, SJ (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM skrebs@hivresearch.org
FU H.M.J. Foundation for the Advancement of Military Medicine, Inc.
[W81XWH-11-2-0174]; US Department of Defense [W81XWH-11-2-0174]; NIH
[R01NS084911]
FX This work was supported by a cooperative agreement (W81XWH-11-2-0174)
between the H.M.J. Foundation for the Advancement of Military Medicine,
Inc. and the US Department of Defense. J.A. was partially supported by
NIH R01NS084911.
NR 43
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Z9 8
U1 3
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1746-630X
EI 1746-6318
J9 CURR OPIN HIV AIDS
JI Curr. Opin. HIV AIDS
PD MAR
PY 2016
VL 11
IS 2
BP 163
EP 172
DI 10.1097/COH.0000000000000228
PG 10
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA DD1AE
UT WOS:000369652400006
PM 26599167
ER
PT J
AU Narkhede, M
Thota, S
Mosurkal, R
Muller, WS
Kumar, J
AF Narkhede, Mahesh
Thota, Sammaiah
Mosurkal, Ravi
Muller, Wayne S.
Kumar, Jayant
TI Layer-by-layer assembly of halogen-free polymeric materials on
nylon/cotton blend for flame retardant applications
SO FIRE AND MATERIALS
LA English
DT Article
DE water soluble polysiloxanes; phosphates; nylon; cotton blends;
layer-by-layer coating; flame retardant
ID THERMAL-DEGRADATION; COTTON CELLULOSE; NITROGEN; BEHAVIOR;
DECOMPOSITION; PHOSPHORUS; MECHANISMS; DEPOSITION; COATINGS; STYRENE
AB Thin films of environmentally safe, halogen free, anionic sodium phosphate and cationic polysiloxanes were deposited on a Nyco (1:1 nylon/cotton blend) fabric via layer-by-layer (LbL) assembly to reduce the inherent flammability of Nyco fabric. In the coating process, we used three different polysiloxane materials containing different amine groups including, 35-45% (trimethylammoniummethylphenythyl)-methyl siloxane-55-65% dimethyl siloxane copolymer chloride salt (QMS-435), aminoethylaminopropyl silsesquioxane-methylsilsesquioxane copolymer oligomer (WSA-7021) and aminopropyl silesquioxane oligomers (WSA-991), as a positive polyelectrolyte. Thermo-gravimetric analysis showed that coated fabric has char yield around 40% at 600 degrees C whereas control fabric was completely consumed. The vertical flame test (VFT) on the LbL-coated Nyco fabric was passed with after flame time, 2s, and the char length of 3.81cm. Volatile and nontoxic degradation products of flame retardant-coated fabric were analyzed by pyrolysis gas chromatography mass spectroscopy (Py-GCMS). Surface morphology of coated fabrics and burned fabric residues were studied by scanning electron microscopy. Copyright (c) 2014 John Wiley & Sons, Ltd.
C1 [Narkhede, Mahesh] Univ Massachusetts, Dept Plast Engn, Lowell, MA USA.
[Narkhede, Mahesh; Thota, Sammaiah; Kumar, Jayant] Univ Massachusetts, Ctr Adv Mat, Lowell, MA USA.
[Mosurkal, Ravi; Muller, Wayne S.] US Army, Dev Engn Ctr Natick, Natick Soldier Res, Natick, MA USA.
[Kumar, Jayant] Univ Massachusetts, Dept Phys & Appl Phys, Lowell, MA USA.
RP Mosurkal, R (reprint author), US Army, Dev Engn Ctr Natick, Natick Soldier Res, Natick, MA USA.; Kumar, J (reprint author), Univ Massachusetts, Dept Phys & Appl Phys, Lowell, MA USA.
EM ravi.mosurkal.civ@mail.mil; Jayant_Kumar@uml.edu
RI MOSURKAL, RAVI/P-6981-2015
FU US Army Natick Soldier Research Development and Engineering Center
(NSRDEC)
FX Financial support from US Army Natick Soldier Research Development and
Engineering Center (NSRDEC) is gratefully acknowledged. We thank Pearl
Yip for Py-GCMS measurements.
NR 34
TC 2
Z9 2
U1 10
U2 49
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0308-0501
EI 1099-1018
J9 FIRE MATER
JI Fire Mater.
PD MAR
PY 2016
VL 40
IS 2
BP 206
EP 218
DI 10.1002/fam.2280
PG 13
WC Materials Science, Multidisciplinary
SC Materials Science
GA DC1WT
UT WOS:000369009500003
ER
PT J
AU Bain, ED
Knorr, DB
Richardson, AD
Masser, KA
Yu, J
Lenhart, JL
AF Bain, Erich D.
Knorr, Daniel B., Jr.
Richardson, Adam D.
Masser, Kevin A.
Yu, Jian
Lenhart, Joseph L.
TI Failure processes governing high-rate impact resistance of epoxy resins
filled with core-shell rubber nanoparticles
SO JOURNAL OF MATERIALS SCIENCE
LA English
DT Article
ID ELASTOMER-MODIFIED EPOXIES; CROSS-LINK DENSITY; HIGH-STRAIN RATES;
TOUGHENING MECHANISMS; FRACTURE-TOUGHNESS; BALLISTIC IMPACT;
DEFORMATION-BEHAVIOR; SILICA NANOPARTICLES; ENERGY-DISSIPATION; TRIBLOCK
COPOLYMER
AB Epoxy resins are classically toughened by rubber additives, but the effectiveness of rubber toughening tends to diminish with increasing strain rate, decreasing temperature, and decreasing matrix ductility. In this study, we demonstrate that low loadings of 100-200-nm core-shell rubber (CSR) particulate additives can improve high strain rate (10(4)-10(5) s(-1)) impact resistance by nearly 200 % for epoxy resins with glass transition temperatures T (g) in a range between 60 and 110 A degrees C, without large reductions in T (g) or stiffness. In addition, CSR additives improve low-temperature impact resistance of the epoxies down to 0 A degrees C. Size and surface chemistry of the CSR particles influence the ballistic response, with 200-nm diameter, weakly bound, and poorly dispersed CSR particles providing the greatest toughening performance at low filler loadings and high rates. Impact resistance for a systematic series of CSR-modified epoxies covers a transition from brittle to tough behavior, where the failure mechanism changes with effective fracture resistance. For brittle resins, failure is dominated by initiation of Hertzian cone fracture which depends strongly on fracture toughness K (IC), while for tough resins, failure is dominated by plastic yield at the impact site and is independent of fracture toughness above a minimum K (IC) value of approximately 1.2-1.5 MPa m(1/2). Interestingly, quasistatic mechanical properties are reasonably effective qualitative predictors of high-rate impact resistance, suggesting that the toughening mechanisms of CSR particles are similar over the rates studied here. The insights gained from this study are valuable for design of next generation adhesives, polymers, and polymer composite matrices for lightweight protective applications.
C1 [Bain, Erich D.; Knorr, Daniel B., Jr.; Richardson, Adam D.; Masser, Kevin A.; Yu, Jian; Lenhart, Joseph L.] US Army Res Lab, Aberdeen Proving Ground, MD 20783 USA.
RP Lenhart, JL (reprint author), US Army Res Lab, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 20783 USA.
EM erich.d.bain.civ@mail.mil; daniel.b.knorr.civ@mail.mil;
a.richardson.research@gmail.com; kevin.masser.civ@mail.mil;
jian.h.yu.civ@mail.mil; joseph.l.lenhart.civ@mail.mil
FU Postgraduate Research Participation Program at the U.S. Army Research
Laboratory
FX The authors wish to thank Bryan Love for helpful discussions. EDB and
ADR acknowledge support from the Postgraduate Research Participation
Program at the U.S. Army Research Laboratory administered by the Oak
Ridge Institute for Science and Education through an interagency
agreement between the U.S. Department of Energy and USARL.
NR 102
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Z9 5
U1 15
U2 63
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0022-2461
EI 1573-4803
J9 J MATER SCI
JI J. Mater. Sci.
PD MAR
PY 2016
VL 51
IS 5
BP 2347
EP 2370
DI 10.1007/s10853-015-9544-5
PG 24
WC Materials Science, Multidisciplinary
SC Materials Science
GA DA3EZ
UT WOS:000367680800013
ER
PT J
AU Oh, SC
Wu, YQ
Tran, DT
Lee, IC
Lei, Y
Liu, DX
AF Oh, Su Cheun
Wu, Yiqing
Tran, Dat T.
Lee, Ivan C.
Lei, Yu
Liu, Dongxia
TI Influences of cation and anion substitutions on oxidative coupling of
methane over hydroxyapatite catalysts
SO FUEL
LA English
DT Article
DE Hydroxyapatite; Membrane reactor; Anion and cation substitution;
Methane; Oxidative coupling
ID CALCIUM HYDROXYAPATITE; MEMBRANE REACTOR; CARBONATE; LEAD; CONVERSION;
MECHANISM; BIOMATERIALS; CONDUCTION; CHEMICALS; ETHYLENE
AB Lead substituted hydroxyapatite (Pb-HAP) has been an active catalyst for oxidative coupling of methane (OCM) reactions. CO32- substituted HAP (HAP-CO3) has showed enhanced oxide ion conductivity than bare HAP in high temperature solid oxide fuel cells. Substitutions for both cations and anions in HAP structure (Pb-HAP-CO3) are promising to integrate the catalytic property of Pb-HAP and oxide ion conductive property of HAP-CO3 into one apatite-based ceramic material that can be manufactured into membrane reactors for possessing CH4 activation and O-2 permeation capabilities for efficient OCM reactions. In this work, the effects of substitutions for both cation (Pb2+) and anion (CO32-) in HAP structure on OCM reactions were studied. The composition and physicochemical properties of HAP catalysts were changed by the cation and anion substitutions, respectively, and as consequences, they influenced the catalytic performances of HAP structure in OCM reactions. The selectivity to C-2 (ethylene and ethane) products increased in the order of HAP-CO3 < HAP < Pb-HAP-CO3 < Pb-HAP, while Pb-HAP-CO3 showed the best stability and comparable C-2 yield (under optimized reaction conditions) to Pb-HAP catalyst. Under different reaction temperature and/or CH4/O-2 ratio in the OCM reactions, the CH4 conversion and C-2 or COx (CO and CO2) selectivity showed a strong dependence on the composition of HAP-based catalysts. The present study forms a basis for understanding of the correlations between the composition, structure, and catalytic performance of HAP and other apatite structured catalysts, which are potential membrane materials for OCM reactions in membrane reactors. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Oh, Su Cheun; Wu, Yiqing; Liu, Dongxia] Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA.
[Tran, Dat T.; Lee, Ivan C.] US Army, Res Lab, RDRL SED E, Adelphi, MD 20783 USA.
[Lei, Yu] Univ Alabama, Chem & Mat Engn, Huntsville, AL 35899 USA.
RP Liu, DX (reprint author), Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA.
EM liud@umd.edu
RI BM, MRCAT/G-7576-2011;
OI Lei, Yu/0000-0002-4161-5568
FU American Chemical Society Petroleum Research Fund - United States
(ACS-PRF); National Science Foundation - United States [NSF-CBET
1264599]; Maryland NanoCenter; NispLab; NSF; Department of Energy; MRCAT
member institutions; DOE Office of Science by Argonne National
Laboratory [DE-AC02-06CH11357]
FX The authors gratefully acknowledge financial support from the American
Chemical Society Petroleum Research Fund - United States (ACS-PRF) and
National Science Foundation - United States (NSF-CBET 1264599). We
acknowledge the support of Maryland NanoCenter and its NispLab. The
NispLab is supported in part by the NSF as a MRSEC Shared Experimental
Facility. MRCAT operations are supported by the Department of Energy and
the MRCAT member institutions. This research used resources of the
Advanced Photon Source, a U.S. Department of Energy (DOE) Office of
Science User Facility operated for the DOE Office of Science by Argonne
National Laboratory under Contract No. DE-AC02-06CH11357.
NR 44
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U1 9
U2 64
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0016-2361
EI 1873-7153
J9 FUEL
JI Fuel
PD MAR 1
PY 2016
VL 167
BP 208
EP 217
DI 10.1016/j.fuel.2015.11.058
PG 10
WC Energy & Fuels; Engineering, Chemical
SC Energy & Fuels; Engineering
GA CY8IG
UT WOS:000366651400023
ER
PT J
AU Hughes, BH
Perkins, LB
Yang, TC
Skonberg, DI
AF Hughes, Brianna H.
Perkins, L. Brian
Yang, Tom C.
Skonberg, Denise I.
TI Impact of post-rigor high pressure processing on the physicochemical and
microbial shelf-life of cultured red abalone (Haliotis rufescens)
SO FOOD CHEMISTRY
LA English
DT Article
DE Abalone; High pressure; Quality; Shelf-life
ID HIGH HYDROSTATIC-PRESSURE; REFRIGERATED STORAGE; BIOCHEMICAL-CHANGES;
MODIFIED ATMOSPHERE; FISH PRODUCTS; MUSCLE; QUALITY; TRIMETHYLAMINE;
TEXTURE; AMINES
AB High pressure processing (HPP) of post-rigor abalone at 300 MPa for 10 min extended the refrigerated shelf-life to four times that of unprocessed controls. Shucked abalone meats were processed at 100 or 300 MPa for 5 or 10min, and stored at 2 degrees C for 35 days. Treatments were analyzed for aerobic plate count (APC), total volatile base nitrogen (TVBN), K-value, biogenic amines, color, and texture. APC did not exceed 10(6) and TVBN levels remained below 35 mg/100 g for 35 days for the 300 MPa treatments. No biogenic amines were detected in the 300 MPa treatments, but putrescine and cadaverine were detected in the control and 100 MPa treatments. Color and texture were not affected by HPP or storage time. These results indicate that post-rigor processing at 300 MPa for 10 min can significantly increase refrigerated shelf-life of abalone without affecting chemical or physical quality characteristics important to consumers. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Hughes, Brianna H.; Perkins, L. Brian; Skonberg, Denise I.] Univ Maine, Sch Food & Agr, Orono, ME 04469 USA.
[Yang, Tom C.] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA.
RP Skonberg, DI (reprint author), Univ Maine, Sch Food & Agr, 5735 Hitchner Hall, Orono, ME 04469 USA.
EM Denise.Skonberg@umit.maine.edu
FU UMaine ADVANCE Rising Tide Center
FX The authors gratefully acknowledge the help and support of Marissa
Rublee, Phoebe Hodson, Katie Feeney, Beth Fulton, Chris Mishoe, Richard
Lopes, and Mary Scerra, Brad Buckley and The Abalone Farm for providing
discounted live abalones, and the UMaine ADVANCE Rising Tide Center for
funding. This manuscript is number 3435 of the University of Maine
Agricultural and Forest Experiment Station.
NR 34
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U1 7
U2 52
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0308-8146
EI 1873-7072
J9 FOOD CHEM
JI Food Chem.
PD MAR 1
PY 2016
VL 194
BP 487
EP 494
DI 10.1016/j.foodchem.2015.07.144
PG 8
WC Chemistry, Applied; Food Science & Technology; Nutrition & Dietetics
SC Chemistry; Food Science & Technology; Nutrition & Dietetics
GA CV4PL
UT WOS:000364248900065
PM 26471583
ER
PT J
AU Bozue, JA
Chaudhury, S
Amemiya, K
Chua, J
Cote, CK
Toothman, RG
Dankmeyer, JL
Klimko, CP
Wilhelmsen, CL
Raymond, JW
Zavaljevski, N
Reifman, J
Wallqvist, A
AF Bozue, Joel A.
Chaudhury, Sidhartha
Amemiya, Kei
Chua, Jennifer
Cote, Christopher K.
Toothman, Ronald G.
Dankmeyer, Jennifer L.
Klimko, Christopher P.
Wilhelmsen, Catherine L.
Raymond, Jolynn W.
Zavaljevski, Nela
Reifman, Jaques
Wallqvist, Anders
TI Phenotypic Characterization of a Novel Virulence-Factor Deletion Strain
of Burkholderia mallei That Provides Partial Protection against
Inhalational Glanders in Mice
SO FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
LA English
DT Article
DE Burkholderia mallei; virulence factor; live-attenuated vaccine;
glanders; aerosol
ID ACTIN-BASED MOTILITY; VI SECRETION; BALB/C MICE; MURINE MACROPHAGES;
PSEUDOMALLEI; VACCINE; MELIOIDOSIS; SYSTEM; MUTANT; MODEL
AB Burkholderia mallei (Bm) is a highly infectious intracellular pathogen classified as a category B biological agent by the Centers for Disease Control and Prevention. After respiratory exposure, Bm establishes itself within host macrophages before spreading into major organ systems, which can lead to chronic infection, sepsis, and death. Previously, we combined computational prediction of host-pathogen interactions with yeast two-hybrid experiments and identified novel virulence factor genes in Bm, including BMAA0553, BMAA0728 (tssN), and BMAA1865. In the present study, we used recombinant allelic exchange to construct deletion mutants of BMAA0553 and tssN (Delta BMAA0553 and Delta TssN, respectively) and showed that both deletions completely abrogated virulence at doses of >100 times the LD50 of the wild-type Bm strain. Analysis of Delta BMAA0553- and Delta TssN-infected mice showed starkly reduced bacterial dissemination relative to wild-type Bm, and subsequent in vitro experiments characterized pathogenic phenotypes with respect to intracellular growth, macrophage uptake and phagosomal escape, actin-based motility, and multinucleated giant cell formation. Based on observed in vitro and in vivo phenotypes, we explored the use of Delta TssN as a candidate live-attenuated vaccine. Mice immunized with aerosolized Delta TssN showed a 21-day survival rate of 67% after a high-dose aerosol challenge with the wild type Bm ATCC 23344 strain, compared to a 0% survival rate for unvaccinated mice. However, analysis of histopathology and bacterial burden showed that while the surviving vaccinated mice were protected from acute infection, Bm was still able to establish a chronic infection. Vaccinated mice showed a modest IgG response, suggesting a limited potential of Delta TssN as a vaccine candidate, but also showed prolonged elevation of pro-inflammatory cytokines, underscoring the role of cellular and innate immunity in mitigating acute infection in inhalational glanders.
C1 [Bozue, Joel A.; Amemiya, Kei; Chua, Jennifer; Cote, Christopher K.; Toothman, Ronald G.; Dankmeyer, Jennifer L.; Klimko, Christopher P.] US Army, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA.
[Chaudhury, Sidhartha; Zavaljevski, Nela; Reifman, Jaques; Wallqvist, Anders] US Army, Med Res Inst Infect Dis, Telemed Adv Technol Res Ctr, Biotechnol HPC Software Applicat Inst, Ft Detrick, MD 21702 USA.
[Wilhelmsen, Catherine L.; Raymond, Jolynn W.] US Army, Med Res Inst Infect Dis, Div Pathol, Ft Detrick, MD 21702 USA.
RP Wallqvist, A (reprint author), US Army, Med Res Inst Infect Dis, Telemed Adv Technol Res Ctr, Biotechnol HPC Software Applicat Inst, Ft Detrick, MD 21702 USA.
EM sven.a.wallqvist.civ@mail.mil
FU U.S. Defense Threat Reduction Agency [CBS.MEDBIO.02.10.13H.021]; U.S.
Army Medical Research and Materiel Command, as part of the U.S. Army's
Network Science Initiative
FX The authors thank Vesna Memisevic for discussions on host virulence
factor interactions, David DeShazer for providing the pMo130-Delta
BPSS0403 plasmid used for constructing the Delta BMAA0553 strain, and
Steven Kern and David Fetterer for statistical analysis of these data.
The authors were supported by the U.S. Defense Threat Reduction Agency
(www.dtra.mil; award number CBS.MEDBIO.02.10.13H.021) and by the U.S.
Army Medical Research and Materiel Command (Ft. Detrick, MD), as part of
the U.S. Army's Network Science Initiative. The opinions and assertions
contained herein are the private views of the authors and are not to be
construed as official or as reflecting the views of the U.S. Army or the
U.S. Department of Defense. This paper has been approved for public
release with unlimited distribution.
NR 56
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U1 1
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015,
SWITZERLAND
SN 2235-2988
J9 FRONT CELL INFECT MI
JI Front. Cell. Infect. Microbiol.
PD FEB 26
PY 2016
VL 6
AR 21
DI 10.3389/fcimb.2016.00021
PG 15
WC Immunology; Microbiology
SC Immunology; Microbiology
GA DE7ZN
UT WOS:000370855700001
PM 26955620
ER
PT J
AU Holmes, WW
Keyser, BM
Paradiso, DC
Ray, R
Andres, DK
Benton, BJ
Rothwell, CC
Hoard-Fruchey, HM
Dillman, JF
Sciuto, AM
Anderson, DR
AF Holmes, Wesley W.
Keyser, Brian M.
Paradiso, Danielle C.
Ray, Radharaman
Andres, Devon K.
Benton, Betty J.
Rothwell, Cristin C.
Hoard-Fruchey, Heidi M.
Dillman, James F.
Sciuto, Alfred M.
Anderson, Dana R.
TI Conceptual approaches for treatment of phosgene inhalation-induced lung
injury
SO TOXICOLOGY LETTERS
LA English
DT Article
DE Phosgene; Inhalation; Whole-body; Mechanism; Survival; Treatment;
Toxicity; Mice; Exposure
ID SMOOTH-MUSCLE-CELLS; ION-CHANNEL TRPA1; ENDOTHELIAL-CELLS; NITRIC-OXIDE;
CALCIUM-CHANNELS; PULMONARY-EDEMA; CARDIOVASCULAR-SYSTEM; COVALENT
MODIFICATION; CA2+ CURRENTS; UP-REGULATION
AB Toxic industrial chemicals are used throughout the world to produce everyday products such as household and commercial cleaners, disinfectants, pesticides, pharmaceuticals, plastics, paper, and fertilizers. These chemicals are produced, stored, and transported in large quantities, which poses a threat to the local civilian population in cases of accidental or intentional release. Several of these chemicals have no known medical countermeasures for their toxic effects. Phosgene is a highly toxic industrial chemical which was used as a chemical warfare agent in WWI. Exposure to phosgene causes latent, non-cardiogenic pulmonary edema which can result in respiratory failure and death. The mechanisms of phosgene-induced pulmonary injury are not fully identified, and currently there is no efficacious countermeasure. Here, we provide a proposed mechanism of phosgene-induced lung injury based on the literature and from studies conducted in our lab, as well as provide results from studies designed to evaluate survival efficacy of potential therapies following whole-body phosgene exposure in mice. Several therapies were able to significantly increase 24 h survival following an LCt(50-70) exposure to phosgene; however, no treatment was able to fully protect against phosgene-induced mortality. These studies provide evidence that mortality following phosgene toxicity can be mitigated by neuro- and calcium-regulators, antioxidants, phosphodiesterase and endothelin receptor antagonists, angiotensin converting enzymes, and transient receptor potential cation channel inhibitors. However, because the mechanism of phosgene toxicity is multifaceted, we conclude that a single therapeutic is unlikely to be sufficient to ameliorate the multitude of direct and secondary toxic effects caused by phosgene inhalation. Published by Elsevier Ireland Ltd.
C1 [Holmes, Wesley W.; Paradiso, Danielle C.; Sciuto, Alfred M.; Anderson, Dana R.] US Army, Med Res Inst Chem Def, Analyt Toxicol Div, 2900 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA.
[Keyser, Brian M.; Ray, Radharaman; Andres, Devon K.; Benton, Betty J.; Rothwell, Cristin C.; Hoard-Fruchey, Heidi M.; Dillman, James F.] US Army, Med Res Inst Chem Def, Div Res, 2900 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA.
RP Holmes, WW; Anderson, DR (reprint author), US Army, Med Res Inst Chem Def, Analyt Toxicol Div, 2900 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA.
EM wesley.w.holmes.civ@mail.mil; dana.r.anderson.civ@mail.mil
OI Andres, Devon/0000-0002-6823-4132
FU NIH/NIAID [Y1-A1-6179-04]; USAMRICD [A120-B.P2009-03]
FX Funding: This research was supported by an interagency agreement between
NIH/NIAID (Y1-A1-6179-04) and the USAMRICD (A120-B.P2009-03).
NR 102
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U1 2
U2 11
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0378-4274
EI 1879-3169
J9 TOXICOL LETT
JI Toxicol. Lett.
PD FEB 26
PY 2016
VL 244
BP 8
EP 20
DI 10.1016/j.toxlet.2015.10.010
PG 13
WC Toxicology
SC Toxicology
GA DD1TJ
UT WOS:000369704400003
PM 26562770
ER
PT J
AU Andres, D
Keyser, B
Benton, B
Melber, A
Olivera, D
Holmes, W
Paradiso, D
Anderson, D
Ray, R
AF Andres, Devon
Keyser, Brian
Benton, Betty
Melber, Ashley
Olivera, Dorian
Holmes, Wesley
Paradiso, Danielle
Anderson, Dana
Ray, Radharaman
TI Transient receptor potential (TRP) channels as a therapeutic target for
intervention of respiratory effects and lethality from phosgene
SO TOXICOLOGY LETTERS
LA English
DT Article
DE Phosgene; TRP channels; Inhalation; Calcium signaling; Respiratory
toxicology; SKF; Therapeutic
ID AIRWAY INFLAMMATION; ION CHANNELS; MICE LACKING; LUNG INJURY; DISEASE;
HYPERTENSION; MECHANISMS; INHALATION; SENSATION; EXPOSURE
AB Phosgene (CG), a toxic inhalation and industrial hazard, causes bronchoconstriction, vasoconstriction and associated pathological effects that could be life threatening. Ion channels of the transient receptor potential (TRP) family have been identified to act as specific chemosensory molecules in the respiratory tract in the detection, control of adaptive responses and initiation of detrimental signaling cascades upon exposure to various toxic inhalation hazards (TIH); their activation due to TIH exposure may result in broncho- and vasoconstriction. We studied changes in the regulation of intracellular free Ca2+ concentration ([Ca2+](i)) in cultures of human bronchial smooth muscle cells (BSMC) and human pulmonary microvascular endothelial cells (HPMEC) exposed to CG (16 ppm, 8 min), using an air/liquid interface exposure system. CG increased [Ca2+](i) (p < 0.05) in both cell types, The CG-induced [Ca2+](i) was blocked (p < 0.05) by two types of TRP channel blockers, SKF-96365, a general TRP channel blocker, and RR, a general TRPV (vanilloid type) blocker, in both BSMC and HPMEC. These effects correlate with the in vivo efficacies of these compounds to protect against lung injury and 24 h lethality from whole body CG inhalation exposure in mice (8-10 ppm x 20 min). Thus the TRP channel mechanism appears to be a potential target for intervention in CG toxicity. Published by Elsevier Ireland Ltd.
C1 [Andres, Devon; Keyser, Brian; Benton, Betty; Melber, Ashley; Ray, Radharaman] US Army, Med Res Inst Chem Def, Div Res, Aberdeen Proving Ground, MD 21010 USA.
[Olivera, Dorian; Holmes, Wesley; Paradiso, Danielle; Anderson, Dana] US Army, Med Res Inst Chem Def, Analyt Toxicol Div, Aberdeen Proving Ground, MD 21010 USA.
RP Andres, D (reprint author), US Army, Med Res Inst Chem Def, Div Res, Aberdeen Proving Ground, MD 21010 USA.
EM devon.k.andres.ctr@mail.mil; radharaman.ray.civ@mail.mil
OI Andres, Devon/0000-0002-6823-4132
FU NIH/NIAID [Y1-A1-6179-04]; USAMRICD [A120-B.P2009-03]; U.S. Department
of Energy; U.S. Army Medical Research and Materiel Command (USAMRMC)
FX This research was supported by an interagency agreement between
NIH/NIAID (Y1-A1-6179-04) and the USAMRICD (A120-B.P2009-03).
Additionally this research was supported in part by an appointment to
the Postgraduate Research Participation Program at the U.S. Army Medical
Research Institute of Chemical Defense administered by the Oak Ridge
Institute for Science and Education through an interagency agreement
between the U.S. Department of Energy and U.S. Army Medical Research and
Materiel Command (USAMRMC).
NR 41
TC 0
Z9 0
U1 4
U2 13
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0378-4274
EI 1879-3169
J9 TOXICOL LETT
JI Toxicol. Lett.
PD FEB 26
PY 2016
VL 244
BP 21
EP 27
DI 10.1016/j.toxlet.2015.11.004
PG 7
WC Toxicology
SC Toxicology
GA DD1TJ
UT WOS:000369704400004
PM 26562769
ER
PT J
AU Zhang, K
Balasubramanian, K
Ozsdolay, BD
Mulligan, CP
Khare, SV
Zheng, WT
Gall, D
AF Zhang, K.
Balasubramanian, K.
Ozsdolay, B. D.
Mulligan, C. P.
Khare, S. V.
Zheng, W. T.
Gall, D.
TI Growth and mechanical properties of epitaxial NbN(001) films on MgO(001)
SO SURFACE & COATINGS TECHNOLOGY
LA English
DT Article
DE NbN; Reactive sputtering; Epitaxy; Hardness; Elastic constant; Density
functional theory; Vacancy
ID SURFACE MORPHOLOGICAL EVOLUTION; MAGNETRON SPUTTER-DEPOSITION; NITRIDE
THIN-FILMS; ELECTRONIC TRANSPORT-PROPERTIES; TRANSITION-METAL NITRIDES;
PULSED-LASER DEPOSITION; ENERGY ION-IRRADIATION; SINGLE-CRYSTAL;
PHYSICAL-PROPERTIES; NIOBIUM NITRIDE
AB NbNx layers were deposited by reactive magnetron sputtering on MgO(001) substrates in 0.67 Pa pure N-2 at T-s = 600-1000 degrees C. T-s >= 800 degrees C leads to epitaxial layers with a cube-on-cube relationship to the substrate: (001)(NbN) parallel to(001)(MgO) and [100](NbN)parallel to[100](MgO). The layers are nearly stoichiometric with x = 0.95-0.98 for T-s <= 800 degrees C, but become nitrogen deficient with x = 0.81 and 0.91 for T-s = 900 and 1000 degrees C. X-ray diffraction reciprocal space maps indicate a small in-plane compressive strain of-0.0008 +/- 0.0004 for epitaxial layers, and a relaxed lattice constant that decreases from 4372 A for x = 0.81 to 4363 A for x = 0.98. This unexpected trend is attributed to increasing Nb and decreasing N vacancy concentrations, as quantified by first-principles calculations of the lattice parameter vs. point defect concentration, and consistent with the relatively small calculated formation energies for N and Nb vacancies of 1.00 and-0.67 eV at 0 K and-0.53 and 0.86 eV at 1073 K, respectively. The N-deficient NbN0.81(001) layer exhibits the highest crystalline quality with in-plane and out-of-plane x-ray coherence lengths of 4.5 and 13.8 nm, attributed to a high Nb-adatom diffusion on an N-deficient growth front. However, it also contains inclusions of hexagonal NbN grains which lead to a relatively high measured hardness H = 28.0 +/- 5.1 GPa and elastic modulus E = 406 +/- 70 GPa. In contrast, the nearly stoichiometric phase-pure epitaxial cubic NbN0.98(001) layer has a H = 17.8 +/- 0.7 GPa and E = 315 +/- 13 GPa. The latter value is slightly smaller than 335 and 361 GPa, the isotropic elastic modulus and the [100]-indentation modulus, respectively, predicted for NbN from the calculated c(11) = 641 GPa, c(12) = 140 GPa, and c(44) = 78 GPa. The electrical resistivity ranges from 171 to 437 mu Omega cm at room temperature and 155-646 mu Omega cm at 77 K, suggesting carrier localization due to disorder from vacancies and crystalline defects. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Zhang, K.; Zheng, W. T.] Jilin Univ, MOE, Dept Mat Sci, Key Lab Mobile Mat, Changchun 130012, Peoples R China.
[Zhang, K.; Zheng, W. T.] Jilin Univ, State Key Lab Superhard Mat, Changchun 130012, Peoples R China.
[Zhang, K.; Balasubramanian, K.; Ozsdolay, B. D.; Mulligan, C. P.; Gall, D.] Rensselaer Polytech Inst, Dept Mat Sci & Engn, Troy, NY 12180 USA.
[Mulligan, C. P.] US Army, Armament Res Dev & Engn Ctr, Benet Labs, Watervliet, NY 12189 USA.
[Khare, S. V.] Univ Toledo, Dept Phys & Astron, 2801 W Bancroft St, Toledo, OH 43606 USA.
RP Gall, D (reprint author), Rensselaer Polytech Inst, Dept Mat Sci & Engn, Troy, NY 12180 USA.
EM galld@rpi.edu
RI Gall, Daniel/B-1060-2008; ZHANG, Kan/D-1703-2010;
OI Gall, Daniel/0000-0002-5762-9307; ZHANG, Kan/0000-0003-1354-2784; zheng,
weitao/0000-0002-9028-278X
FU National Science Foundation [1309490, 1537984, 1234777, 1234872];
Chinese Scholarship Council
FX The authors acknowledge support by the National Science Foundation under
Grant Nos. 1309490, 1537984, 1234777, and 1234872, and computational
resources from the Computational Center for Nanotechnology Innovations
at RPI. Kan Zhang thanks the Chinese Scholarship Council for financial
support.
NR 93
TC 2
Z9 3
U1 15
U2 43
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0257-8972
J9 SURF COAT TECH
JI Surf. Coat. Technol.
PD FEB 25
PY 2016
VL 288
BP 105
EP 114
DI 10.1016/j.surfcoat.2016.01.009
PG 10
WC Materials Science, Coatings & Films; Physics, Applied
SC Materials Science; Physics
GA DF7PE
UT WOS:000371549200013
ER
PT J
AU Muldoon, SF
Bridgeford, EW
Bassett, DS
AF Muldoon, Sarah Feldt
Bridgeford, Eric W.
Bassett, Danielle S.
TI Small-World Propensity and Weighted Brain Networks
SO SCIENTIFIC REPORTS
LA English
DT Article
ID COMPLEX NETWORKS; FUNCTIONAL CONNECTIVITY; COMMUNITY STRUCTURE;
PREFRONTAL CORTEX; ORGANIZATION; SCHIZOPHRENIA; NEURODEVELOPMENT;
ARCHITECTURE; MODEL
AB Quantitative descriptions of network structure can provide fundamental insights into the function of interconnected complex systems. Small-world structure, diagnosed by high local clustering yet short average path length between any two nodes, promotes information flow in coupled systems, a key function that can differ across conditions or between groups. However, current techniques to quantify small-worldness are density dependent and neglect important features such as the strength of network connections, limiting their application in real-world systems. Here, we address both limitations with a novel metric called the Small-World Propensity (SWP). In its binary instantiation, the SWP provides an unbiased assessment of small-world structure in networks of varying densities. We extend this concept to the case of weighted brain networks by developing (i) a standardized procedure for generating weighted small-world networks, (ii) a weighted extension of the SWP, and (iii) a method for mapping observed brain network data onto the theoretical model. In applying these techniques to compare realworld brain networks, we uncover the surprising fact that the canonical biological small-world network, the C. elegans neuronal network, has strikingly low SWP. These metrics, models, and maps form a coherent toolbox for the assessment and comparison of architectural properties in brain networks.
C1 [Muldoon, Sarah Feldt; Bridgeford, Eric W.; Bassett, Danielle S.] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA.
[Muldoon, Sarah Feldt] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Muldoon, Sarah Feldt] SUNY Buffalo, Dept Math, Buffalo, NY 14260 USA.
[Muldoon, Sarah Feldt] SUNY Buffalo, Computat & Data Enabled Sci & Engn Program, Buffalo, NY 14260 USA.
[Bridgeford, Eric W.] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD 21218 USA.
[Bassett, Danielle S.] Univ Penn, Dept Elect & Syst Engn, Philadelphia, PA 19104 USA.
RP Bassett, DS (reprint author), Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA.; Bassett, DS (reprint author), Univ Penn, Dept Elect & Syst Engn, Philadelphia, PA 19104 USA.
EM dsb@seas.upenn.edu
OI Muldoon, Sarah/0000-0002-2830-9291
FU John D. and Catherine T. MacArthur Foundation; Alfred P. Sloan
Foundation; Army Research Laboratory; Army Research Office
[W911NF-10-2-0022, W911NF-14-1-0679]; National Institute of Mental
Health [2-R01-DC-009209-11]; National Institute of Child Health and
Human Development [1R01HD086888-01]; Office of Naval Research; National
Science Foundation [BCS-1441502, BCS-1430087]
FX DSI data was collected and preprocessed by Matthew Cieslak and Scott
Grafton, in the Department of Psychological and Brain Sciences at the
University of California, Santa Barbara. This work was supported by the
John D. and Catherine T. MacArthur Foundation, the Alfred P. Sloan
Foundation, the Army Research Laboratory and the Army Research Office
through contract numbers W911NF-10-2-0022 and W911NF-14-1-0679, the
National Institute of Mental Health (2-R01-DC-009209-11), the National
Institute of Child Health and Human Development (1R01HD086888-01), the
Office of Naval Research, and the National Science Foundation
(BCS-1441502 and BCS-1430087).
NR 67
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Z9 7
U1 7
U2 17
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD FEB 25
PY 2016
VL 6
AR 22057
DI 10.1038/srep22057
PG 13
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DE7FE
UT WOS:000370800000001
PM 26912196
ER
PT J
AU Echevarria, AJ
AF Echevarria, Antulio J., II
TI Rediscovering US Military Strategy: A Role for Doctrine
SO JOURNAL OF STRATEGIC STUDIES
LA English
DT Article
DE Doctrine; Military Strategy; RMA; Afghanistan; Transformation
AB This article argues that US military doctrine, and by extension that of most Western militaries, missed an opportunity in the period following the Cold War to rediscover the many types of military strategies employed to good effect before the industrial-age wars of the twentieth century. This missed opportunity resulted in Coalition forces having to relearn many of those strategies through costly trial and error in Iraq and Afghanistan.
C1 [Echevarria, Antulio J., II] US Army War Coll, Carlisle, PA USA.
[Echevarria, Antulio J., II] US Army War Coll, Res, Carlisle, PA USA.
RP Echevarria, AJ (reprint author), US Army War Coll, Carlisle, PA USA.
EM ajech2@yahoo.com
NR 54
TC 0
Z9 0
U1 1
U2 1
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 0140-2390
EI 1743-937X
J9 J STRATEGIC STUD
JI J. Strateg. Stud.
PD FEB 23
PY 2016
VL 39
IS 2
SI SI
BP 231
EP 245
DI 10.1080/01402390.2015.1115035
PG 15
WC International Relations; Political Science
SC International Relations; Government & Law
GA DG6LR
UT WOS:000372196500006
ER
PT J
AU Miller, OD
Polimeridis, AG
Reid, MTH
Hsu, CW
DeLacy, BG
Joannopoulos, JD
Soljacic, M
Johnson, SG
AF Miller, Owen D.
Polimeridis, Athanasios G.
Reid, M. T. Homer
Hsu, Chia Wei
DeLacy, Brendan G.
Joannopoulos, John D.
Soljacic, Marin
Johnson, Steven G.
TI Fundamental limits to optical response in absorptive systems
SO OPTICS EXPRESS
LA English
DT Article
ID ALTERNATIVE PLASMONIC MATERIALS; 2-COMPONENT COMPOSITE-MATERIAL;
SINGULARITY EXPANSION METHOD; ENHANCED RAMAN-SCATTERING; VOLUME
INTEGRAL-EQUATION; CONTROLLED RANDOM SEARCH; RADIATIVE HEAT-TRANSFER;
SPONTANEOUS EMISSION; ELECTROMAGNETIC SCATTERING; PHYSICAL LIMITATIONS
AB At visible and infrared frequencies, metals show tantalizing promise for strong subwavelength resonances, but material loss typically dampens the response. We derive fundamental limits to the optical response of absorptive systems, bounding the largest enhancements possible given intrinsic material losses. Through basic conservation-of-energy principles, we derive geometry-independent limits to per-volume absorption and scattering rates, and to local-density-of-states enhancements that represent the power radiated or expended by a dipole near a material body. We provide examples of structures that approach our absorption and scattering limits at any frequency; by contrast, we find that common "antenna" structures fall far short of our radiative LDOS bounds, suggesting the possibility for significant further improvement. Underlying the limits is a simple metric, vertical bar x vertical bar(2)/Im x for a material with susceptibility x, that enables broad technological evaluation of lossy materials across optical frequencies. (C) 2016 Optical Society of America
C1 [Miller, Owen D.; Reid, M. T. Homer; Johnson, Steven G.] MIT, Dept Math, Cambridge, MA 02139 USA.
[Polimeridis, Athanasios G.] Skolkovo Inst Sci & Technol, Skolkovo 143025, Moscow Region, Russia.
[Hsu, Chia Wei] Yale Univ, Dept Appl Phys, New Haven, CT 06520 USA.
[DeLacy, Brendan G.] US Army Edgewood Chem Biol Ctr, Res & Technol Directorate, Aberdeen Proving Ground, MD 21010 USA.
[Joannopoulos, John D.; Soljacic, Marin] MIT, Dept Phys, Cambridge, MA 02139 USA.
RP Miller, OD (reprint author), MIT, Dept Math, Cambridge, MA 02139 USA.
EM odmiller@math.mit.edu
RI Hsu, Chia Wei/G-5486-2011
OI Hsu, Chia Wei/0000-0002-9609-7155
FU Army Research Office through the Institute for Soldier Nanotechnologies
[W911NF-07-D0004]; AFOSR Multidisciplinary Research Program of the
University Research Initiative (MURI) for Complex and Robust On-chip
Nanophotonics [FA9550-09-1-0704]
FX We thank Eli Yablonovitch, Adi Pick, Yehuda Avniel, Aristeidis Karalis,
Hrvoje Buljan, Alejandro Rodriguez, and Emma Anquillare for helpful
discussions. This work was supported by the Army Research Office through
the Institute for Soldier Nanotechnologies under Contract No.
W911NF-07-D0004, and by the AFOSR Multidisciplinary Research Program of
the University Research Initiative (MURI) for Complex and Robust On-chip
Nanophotonics under Grant No. FA9550-09-1-0704.
NR 179
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Z9 6
U1 2
U2 16
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 1094-4087
J9 OPT EXPRESS
JI Opt. Express
PD FEB 22
PY 2016
VL 24
IS 4
BP 3329
EP 3364
DI 10.1364/OE.24.003329
PG 36
WC Optics
SC Optics
GA DF5ZQ
UT WOS:000371433700017
PM 26906994
ER
PT J
AU Valentin-Torres, A
Savarin, C
Hinton, DR
Phares, TW
Bergmann, CC
Stohlman, SA
AF Valentin-Torres, Alice
Savarin, Carine
Hinton, David R.
Phares, Timothy W.
Bergmann, Cornelia C.
Stohlman, Stephen A.
TI Sustained TNF production by central nervous system infiltrating
macrophages promotes progressive autoimmune encephalomyelitis
SO JOURNAL OF NEUROINFLAMMATION
LA English
DT Article
DE Progressive multiple sclerosis; Experimental autoimmune
encephalomyelitis; Astrocytes; Interferon gamma; Tumor necrosis factor
ID TUMOR-NECROSIS-FACTOR; BLOOD-BRAIN-BARRIER; EXPERIMENTAL ALLERGIC
ENCEPHALOMYELITIS; REGULATORY T-CELLS; MHC CLASS-II; DORSAL-ROOT
GANGLIA; FACTOR-ALPHA; MULTIPLE-SCLEROSIS; TRANSGENIC MICE; SPINAL-CORD
AB Background: Tumor necrosis factor (TNF) has pleiotropic functions during both the demyelinating autoimmune disease multiple sclerosis (MS) and its murine model experimental autoimmune encephalomyelitis (EAE). How TNF regulates disability during progressive disease remains unresolved. Using a progressive EAE model characterized by sustained TNF and increasing morbidity, this study evaluates the role of unregulated TNF in exacerbating central nervous system (CNS) pathology and inflammation.
Methods: Progressive MS was mimicked by myelin oligodendrocyte glycoprotein (MOG) peptide immunization of mice expressing a dominant negative IFN-gamma receptor alpha chain under the human glial fibrillary acidic protein promoter (GFAP gamma R1 Delta). Diseased GFAP gamma R1 Delta mice were treated with anti-TNF or control monoclonal antibody during acute disease to monitor therapeutic effects on sustained disability, demyelination, CNS inflammation, and blood brain barrier (BBB) permeability.
Results: TNF was specifically sustained in infiltrating macrophages. Anti-TNF treatment decreased established clinical disability and mortality rate within 7 days. Control of disease progression was associated with a decline in myelin loss and leukocyte infiltration, as well as macrophage activation. In addition to mitigating CNS inflammation, TNF neutralization restored BBB integrity and enhanced CNS anti-inflammatory responses.
Conclusions: Sustained TNF production by infiltrating macrophages associated with progressive EAE exacerbates disease severity by promoting inflammation and disruption of BBB integrity, thereby counteracting establishment of an anti-inflammatory environment required for disease remission.
C1 [Valentin-Torres, Alice; Savarin, Carine; Bergmann, Cornelia C.; Stohlman, Stephen A.] Cleveland Clin, Lerner Res Inst, Dept Neurosci NC 30, 9500 Euclid Ave, Cleveland, OH 44195 USA.
[Hinton, David R.] Univ So Calif, Keck Sch Med, Dept Pathol, Los Angeles, CA 90033 USA.
[Phares, Timothy W.] Walter Reed Army Inst Res, Malaria Vaccine Branch, Silver Spring, MD 20910 USA.
RP Bergmann, CC (reprint author), Cleveland Clin, Lerner Res Inst, Dept Neurosci NC 30, 9500 Euclid Ave, Cleveland, OH 44195 USA.
EM bergmac@ccf.org
FU National Multiple Sclerosis Society [RG4007B5]; Cancer Center Support
grant [P30CA014089]; NIH
FX The authors would like to thank Natasha Towne, Kate Stenson, Wen Wei,
and Ernesto Barron for their exceptional technical assistance. This work
was supported by the National Multiple Sclerosis Society research grant
RG4007B5 and Cancer Center Support grant P30CA014089. Research reported
here was supported by a 2015 NIH shared instrument award to the LRI
Imaging Core for the Leica TCS-SP5II.
NR 76
TC 4
Z9 4
U1 1
U2 4
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1742-2094
J9 J NEUROINFLAMM
JI J. Neuroinflamm.
PD FEB 22
PY 2016
VL 13
AR 46
DI 10.1186/s12974-016-0513-y
PG 14
WC Immunology; Neurosciences
SC Immunology; Neurosciences & Neurology
GA DE6WS
UT WOS:000370775900002
PM 26906225
ER
PT J
AU Bricker, SB
Getchis, TL
Chadwick, CB
Rose, C
Rose, JM
AF Bricker, Suzanne B.
Getchis, Tessa L.
Chadwick, Cary B.
Rose, Corim.
Rose, Julie M.
TI Integration of ecosystem-based models into an existing interactive
web-based tool for improved aquaculture decision-making
SO AQUACULTURE
LA English
DT Article
DE Shellfish; Aquaculture; GIS; Decision support tool
ID DATA-POOR ENVIRONMENTS; SHELLFISH AQUACULTURE; CARRYING-CAPACITY; SITE
SELECTION; MANAGEMENT; CULTURE; ESTUARY; GIS; INDICATORS; SOUND
AB Proper site selection is critical to the development and expansion of marine aquaculture. Major considerations for site selection include: potential for competing uses, environmental interactions, and animal productivity. Two types of existing site selection tools, mapping and modeling, have proven useful independently, and in some recent studies have proven useful when used together. GIS-based mapping tools have become important in the decision-making process. These tools provide access to marine and coastal datasets allowing farmers and extension agents to gather information on availability of cultivation sites. They are also used by resource managers to assess potential use conflicts (e.g. existence of commercial fishing, mooring areas, fixed fishing gear) and possible environmental interactions (e.g. presence of seagrasses, contaminants, threatened or endangered species). Models have been used separately to predict animal growth, farm productivity, and farm-related effects on the surrounding water and sediment quality.
The integration of the Farm Aquaculture Resource Management (FARM) model (http://www.farmscale.org) into the U.S. state of Connecticut's Aquaculture Mapping Atlas (http://seagrant.uconn.edu/whatwedo/aquaculture/shellmap.php) was tested in three geographically distinct waterbodies within Connecticut (CT) waters of Long Island Sound. Nearshore waters within the towns of Mystic, Milford, and Westport were selected as pilot locations to determine usability and capability of the combined tools. Data from two long-term offshore sampling stations adjacent to existing shellfish leases were used to test spatial and temporal sampling variability impacts on model results. Partnerships with local monitoring programs and growers were important for acquisition of water quality data, oyster measurement data, and information about local culture practices. All sites were deemed suitable for oyster aquaculture based on model results that predicted Moderate to High growth based on estimated time to reach harvest size from one in (2.54 cm) seed oysters (Crassostrea virginica). Time to harvest varied from 282 days (High growth) to 645 days (Moderate growth) among the 22 stations in the three nearshore sites, and 724-956 days (Moderate growth) at the two offshore sites. Results from the two long-term offshore stations indicate that data from the same year must be used when comparing production-based suitability of sites. Addition of potential production estimates improved the ability to select between suitable mapping-based sites. This mapping and modeling combination should be encouraged to provide a strong basis for successful siting and expansion of aquaculture while minimizing user conflict and adverse environmental interactions. This approach may be particularly useful in waterbodies where shellfish aquaculture is possible but is not well established. Published by Elsevier B.V.
C1 [Bricker, Suzanne B.] NOAA, Natl Ctr Coastal Sci, Silver Spring, MD 20910 USA.
[Getchis, Tessa L.] Univ Connecticut, UConn Extens, Connecticut Sea Grant, Groton, CT USA.
[Chadwick, Cary B.] Univ Connecticut, Ctr Land Use Educ & Res, Haddam, CT USA.
[Rose, Corim.] US Army, Corps Engnineers, Concord, MA USA.
[Rose, Julie M.] NOAA, Fisheries Northeast Fisheries Sci Ctr Milford Lab, Milford, CT USA.
RP Bricker, SB (reprint author), NOAA, Natl Ctr Coastal Sci, 1305 East West Highway,Floor 9, Silver Spring, MD 20910 USA.
EM suzanne.bricker@noaa.gov
FU NOAA Aquaculture Program Call for Internal Proposals
[NS-COAST-001-Bricker]
FX The authors gratefully acknowledge the NOAA Aquaculture Program 2012
Call for Internal Proposals for funding this research under Project
NS-COAST-001-Bricker. We wish to thank: Sally Cogan and Claire Gavin of
Clean Up Sound and Harbors (CUSH) for the samples from Mystic River
stations, Dick Harris, Nikki Cantatore, and Josh Cooper with HarborWatch
for the Westport/Mill Pond samples, Bob Alix and Werner Schreiner for
the help in collecting the Milford samples, Karen Rivara, Aeros Cultured
Oyster Co., for measuring and weighing seed oysters, S. Plant, CT
Cultured Oysters, for providing oysters for additional
measurement/weight determinations, and Kristen DeRosia Banick,
Connecticut Bureau of Aquaculture, for the information about typical
oyster aquaculture practices. We also thank Ramon Filgueira and three
anonymous reviewers for their thorough reviews, comments, and
suggestions which have vastly improved our manuscript.
NR 42
TC 1
Z9 1
U1 12
U2 61
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0044-8486
EI 1873-5622
J9 AQUACULTURE
JI Aquaculture
PD FEB 20
PY 2016
VL 453
BP 135
EP 146
DI 10.1016/j.aquaculture.2015.11.036
PG 12
WC Fisheries; Marine & Freshwater Biology
SC Fisheries; Marine & Freshwater Biology
GA CZ0OC
UT WOS:000366803800018
ER
PT J
AU Cheuvront, SN
Kenefick, RW
AF Cheuvront, Samuel N.
Kenefick, Robert W.
TI Am I Drinking Enough? Yes, No, and Maybe
SO JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
LA English
DT Review
DE dehydration; hypohydration; hydration assessment; hydration status;
plasma osmolality; urine osmolality
ID WATER-INTAKE; HYDRATION STATUS; PLASMA VASOPRESSIN; ESSENTIAL NUTRIENT;
BLOOD OSMOLALITY; URINE VOLUME; FLUID INTAKE; THIRST; OSMOREGULATION;
DEHYDRATION
AB Adequate fluid intake can be dually defined as a volume of fluid (from water, beverages, and food) sufficient to replace water losses and provide for solute excretion. A wide range of fluid intakes are compatible with euhydration, whereby total body water varies narrowly from day to day by 600 to 900mL (<1% body mass). One measure of fluid intake adequacy involves enough fluid to prevent meaningful body water deficits outside this euhydration range (i.e., dehydration). Another measure of fluid intake adequacy involves enough fluid to balance the renal solute load, which can vary widely inside the euhydration range. The subtle but important distinction between the 2 types of adequacy may explain some of the ambiguity surrounding the efficacy of hydration status markers. Both perspectives of fluid intake adequacy are discussed in detail and a simple tool is reviewed that may help healthy, active, low-risk populations answer the question, Am I drinking enough?Key Teaching Points center dot Adequate fluid intake can be dually defined as a volume of fluid (from water, beverages, and food) sufficient to replace water losses and provide for solute excretion.center dot Fluid needs can differ greatly among individuals due to variation in the factors that influence both water loss and solute balance; thus, adequacy is consistent with a wide range of fluid intakes and is better gauged using hydration assessment methods.center dot Adequacy of fluid intake for replacing meaningful water losses (dehydration) can be assessed simply, inexpensively, and with reasonable fidelity among healthy, active, low-risk individuals.center dot Adequacy of fluid intake for solute excretion per se can also be assessed among individuals but is more difficult to define and less practical to measure.
C1 [Cheuvront, Samuel N.; Kenefick, Robert W.] US Army Res Inst Environm Med, 15 Kansas St,Bldg 42, Natick, MA 01760 USA.
RP Cheuvront, SN (reprint author), US Army Res Inst Environm Med, 15 Kansas St,Bldg 42, Natick, MA 01760 USA.
EM samuel.n.cheuvront.civ@mail.mil
NR 75
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PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 0731-5724
EI 1541-1087
J9 J AM COLL NUTR
JI J. Am. Coll. Nutr.
PD FEB 17
PY 2016
VL 35
IS 2
BP 185
EP 192
DI 10.1080/07315724.2015.1067872
PG 8
WC Nutrition & Dietetics
SC Nutrition & Dietetics
GA DG5AU
UT WOS:000372085400012
PM 26885571
ER
PT J
AU von Pressentin, K
Hoedebecke, K
Pinho-Costa, L
AF von Pressentin, Klaus
Hoedebecke, Kyle
Pinho-Costa, Luis
TI South Africa has joined a global initiative for Family Medicine advocacy
SO SOUTH AFRICAN FAMILY PRACTICE
LA English
DT Letter
AB The international #1WordforFamilyMedicine initiative serves to explore the identity of family physicians and allows the international Family Medicine community to collaborate on advocating the discipline. South African family physicians provided 42 responses via a social media and online survey. Two word cloud images were created based on two iconsrecognised as being truly South African around the world - that of the national flag and former president Nelson Mandela. The #1WorldforFamilyMedicine initiative was promoted by the World Organization of Family Doctors across the globe to help celebrate World Family Doctor Day on 19 May 2015. To date, over 70 images have been created in 50 different countries on six continents. The images represent family physicians' love for their profession and the community they serve. It is hoped that this initiative will help to inspire current and future Family Medicine and primary care providers.
C1 [von Pressentin, Klaus] Univ Stellenbosch, Div Family Med & Primary Care, Cape Town, South Africa.
[Hoedebecke, Kyle] World Org Family Doctors WONCA Polaris, North Carolina & Robinson Hlth Clin, Dept Family Med, Ft Bragg, NC USA.
[Pinho-Costa, Luis] Fanzeres Family Hlth Unit, Gondomar, Portugal.
RP von Pressentin, K (reprint author), Univ Stellenbosch, Div Family Med & Primary Care, Cape Town, South Africa.
EM kvonpressentin@sun.ac.za
OI de Pinho-Costa, Luis/0000-0001-9241-4144
NR 4
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U1 0
U2 0
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 2078-6190
EI 2078-6204
J9 S AFR FAM PRACT
PD FEB 17
PY 2016
VL 58
IS 1
BP 28
EP 29
DI 10.1080/20786190.2015.1085224
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA DG4DL
UT WOS:000372021000007
ER
PT J
AU Lin, CT
Chuang, CH
Kerick, S
Mullen, T
Jung, TP
Ko, LW
Chen, SA
King, JT
McDowell, K
AF Lin, Chin-Teng
Chuang, Chun-Hsiang
Kerick, Scott
Mullen, Tim
Jung, Tzyy-Ping
Ko, Li-Wei
Chen, Shi-An
King, Jung-Tai
McDowell, Kaleb
TI Mind-Wandering Tends to Occur under Low Perceptual Demands during
Driving
SO SCIENTIFIC REPORTS
LA English
DT Article
ID INDEPENDENT COMPONENT ANALYSIS; THETA OSCILLATIONS REFLECT; DEFAULT
NETWORK; FUNCTIONAL CONNECTIVITY; EEG DYNAMICS; HUMAN BRAIN; TASK;
PERFORMANCE; CORTEX; ENVIRONMENT
AB Fluctuations in attention behind the wheel poses a significant risk for driver safety. During transient periods of inattention, drivers may shift their attention towards internally-directed thoughts or feelings at the expense of staying focused on the road. This study examined whether increasing task difficulty by manipulating involved sensory modalities as the driver detected the lane-departure in a simulated driving task would promote a shift of brain activity between different modes of processing, reflected by brain network dynamics on electroencephalographic sources. Results showed that depriving the driver of salient sensory information imposes a relatively more perceptually-demanding task, leading to a stronger activation in the task-positive network. When the vehicle motion feedback is available, the drivers may rely on vehicle motion to perceive the perturbations, which frees attentional capacity and tends to activate the default mode network. Such brain network dynamics could have major implications for understanding fluctuations in driver attention and designing advance driver assistance systems.
C1 [Lin, Chin-Teng; Chuang, Chun-Hsiang; Ko, Li-Wei; Chen, Shi-An; King, Jung-Tai] Natl Chiao Tung Univ, Brain Res Ctr, MIRC 416,1001 Univ Rd, Hsinchu 30010, Taiwan.
[Lin, Chin-Teng; Chuang, Chun-Hsiang] Univ Technol Sydney, 15 Broadway, Ultimo, NSW 2007, Australia.
[Kerick, Scott; McDowell, Kaleb] US Army Res Lab, Translat Neurosci Branch, 459 Mulberry Point Rd, Aberdeen Proving Ground, MD 21005 USA.
[Mullen, Tim; Jung, Tzyy-Ping] Univ Calif San Diego, Swartz Ctr Computat Neurosci, 9500 Gilman Dr, La Jolla, CA 92093 USA.
[Ko, Li-Wei] Natl Chiao Tung Univ, Dept Biol Sci & Technol, Hsinchu 30010, Taiwan.
RP Lin, CT; Chuang, CH (reprint author), Natl Chiao Tung Univ, Brain Res Ctr, MIRC 416,1001 Univ Rd, Hsinchu 30010, Taiwan.; Lin, CT; Chuang, CH (reprint author), Univ Technol Sydney, 15 Broadway, Ultimo, NSW 2007, Australia.
EM ctlin@mail.nctu.edu.tw; cch.chuang@gmail.com
OI Chuang, Chun-Hsiang/0000-0002-5043-8380
FU UST-UCSD International Center of Excellence in Advanced Bioengineering -
Taiwan Ministry of Science and Technology I-RiCE Program [MOST
103-2911-I-009-101]; Aiming for the Top University Plan of National
Chiao Tung University; Ministry of Education, Taiwan [104W963]; Army
Research Laboratory [W911NF-10-2-0022]
FX This work was supported in part by the UST-UCSD International Center of
Excellence in Advanced Bioengineering sponsored by the Taiwan Ministry
of Science and Technology I-RiCE Program under Grant Number MOST
103-2911-I-009-101, in part by the Aiming for the Top University Plan of
National Chiao Tung University, the Ministry of Education, Taiwan, under
Contract 104W963. Research was also sponsored in part by the Army
Research Laboratory and was accomplished under Cooperative Agreement
Number W911NF-10-2-0022. The U.S. Government is authorized to reproduce
and distribute reprints for Government purposes notwithstanding any
copyright notation heron.
NR 61
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U1 3
U2 11
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD FEB 17
PY 2016
VL 6
AR 21353
DI 10.1038/srep21353
PG 11
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DE0MD
UT WOS:000370318100001
PM 26882993
ER
PT J
AU Lyon, R
Berry-Caban, CS
Lyon, C
Markowski, H
Boltinhouse, SL
AF Lyon, Regan
Berry-Caban, Cristobal S.
Lyon, Christopher
Markowski, Helen
Boltinhouse, Sara L.
TI Factors affecting conviction rates of intoxicated driver patients in two
large trauma centers
SO TRAFFIC INJURY PREVENTION
LA English
DT Article
DE alcoholism; emergency department; trauma; DUI
ID INJURY SEVERITY SCORE; UNITED-STATES; ALCOHOL; CARE; ENFORCEMENT;
CRASHES; LIMITS; LAWS; BAC
AB Objective: Outcomes from previous studies report the driving under the influence (DUI) conviction rates for trauma patients in several cities within Canada and the United States over the last 2 decades. This study reports charge, conviction, and prosecution rates for trauma patients at 2 level I trauma centers servicing a large metropolitan city.
Methods: A retrospective review of the trauma databases was completed to identify patients meeting inclusion criteria. Four hundred sixty patients were identified and their records were compared with the district attorney's records for DUI charges and convictions.
Results: The conviction rate for this study was 8.7%, demonstrating continued low rates of conviction despite growing interest and public awareness of drinking and driving.
Conclusions: We discuss legal considerations that providers should consider when treating patients who have been drinking and driving.
C1 [Lyon, Regan] Emergency Dept, 51st Med Operat Squadron, Osan Ab, South Korea.
[Berry-Caban, Cristobal S.; Boltinhouse, Sara L.] Womack Army Med Ctr, Dept Clin Invest, Ft Bragg, NC USA.
[Lyon, Christopher] Wood Smith Henning & Berman LLP Law Firm, New York, NY USA.
[Markowski, Helen] Univ Texas Hlth Sci Ctr San Antonio, San Antonio Univ Hosp, Trauma Surg, San Antonio, TX 78229 USA.
RP Berry-Caban, CS (reprint author), Womack Army Med Ctr, Dept Clin Invest, Ft Bragg, NC USA.; Berry-Caban, CS (reprint author), Womack Army Med Ctr, DME RES, Dept Clin Invest, Ft Bragg, NC USA.
EM cristobal.s.berry-caban.civ@mail.mil
NR 30
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Z9 0
U1 0
U2 3
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1538-9588
EI 1538-957X
J9 TRAFFIC INJ PREV
JI Traffic Inj. Prev.
PD FEB 17
PY 2016
VL 17
IS 2
BP 109
EP 113
DI 10.1080/15389588.2015.1045503
PG 5
WC Public, Environmental & Occupational Health; Transportation
SC Public, Environmental & Occupational Health; Transportation
GA DE4TP
UT WOS:000370623500002
PM 26042876
ER
PT J
AU Racke, DA
Neupane, MR
Monti, OLA
AF Racke, David A.
Neupane, Mahesh R.
Monti, Oliver L. A.
TI Valence and conduction band structure of the quasi-two-dimensional
semiconductor SnS2
SO PHYSICAL REVIEW B
LA English
DT Article
ID TRANSITION-METAL DICHALCOGENIDES; SINGLE-LAYER MOS2; TIN DISULFIDE;
2-DIMENSIONAL MATERIALS; ELECTRONIC-STRUCTURE; EDGE STATES; GAP STATES;
PHOTOEMISSION; INTERFACES; DYNAMICS
AB We present the momentum-resolved photoemission spectroscopy of both the valence and the conduction band region in the quasi-two-dimensional van der Waals-layered indirect band gap semiconductor SnS2. Using a combination of angle-resolved ultraviolet photoemission and angle-resolved two-photon photoemission (AR-2PPE) spectroscopy, we characterize the band structure of bulk SnS2. Comparison with density functional theory calculations shows excellent quantitative agreement in the valence band region and reveals several localized bands that likely originate from defects such as sulfur vacancies. Evidence for a moderate density of defects is also observed by AR-2PPE in the conduction band region, leading to localized bands not present in the computational results. The energetic structure and dispersion of the conduction bands is captured well by the computational treatment, with some quantitative discrepancies remaining. Our results provide a broader understanding of the electronic structure of SnS2 in particular and van der Waals-layered semiconductors in general.
C1 [Racke, David A.; Monti, Oliver L. A.] Univ Arizona, Dept Chem & Biochem, Tucson, AZ 85721 USA.
[Neupane, Mahesh R.] US Army Res Lab, Macromol Sci & Technol Branch, Aberdeen Proving Ground, MD 21005 USA.
[Monti, Oliver L. A.] Univ Arizona, Dept Phys, Tucson, AZ 85721 USA.
RP Monti, OLA (reprint author), Univ Arizona, Dept Chem & Biochem, Tucson, AZ 85721 USA.; Neupane, MR (reprint author), US Army Res Lab, Macromol Sci & Technol Branch, Aberdeen Proving Ground, MD 21005 USA.; Monti, OLA (reprint author), Univ Arizona, Dept Phys, Tucson, AZ 85721 USA.
EM mahesh.neupane.ctr@mail.mil; monti@u.arizona.edu
FU Department of Defense (DOD) High Performance Computing Modernization
Program at the US Air Force Research Laboratory; US Army Engineer
Research and Development Center DOD Supercomputing Resource Centers;
National Science Foundation [CHE-1213243]
FX M.R.N. was supported by an appointment to the Postgraduate Research
Participation Program at the US Army Research Laboratory (USARL)
administered by the Oak Ridge Institute for Science and Education
through an interagency agreement between the US Department of Energy and
the USARL. The computational work was supported by grants from the
Department of Defense (DOD) High Performance Computing Modernization
Program at the US Air Force Research Laboratory and US Army Engineer
Research and Development Center DOD Supercomputing Resource Centers.
D.A.R. and O.L.A.M. are grateful for financial support from the National
Science Foundation under Grant No. CHE-1213243. We also acknowledge
Prof. Bruce Parkinson (University of Wyoming) for generously providing
us with SnS2 crystals.
NR 60
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U1 22
U2 72
PU AMER PHYSICAL SOC
PI COLLEGE PK
PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA
SN 2469-9950
EI 2469-9969
J9 PHYS REV B
JI Phys. Rev. B
PD FEB 17
PY 2016
VL 93
IS 8
AR 085309
DI 10.1103/PhysRevB.93.085309
PG 7
WC Physics, Condensed Matter
SC Physics
GA DD9LD
UT WOS:000370246100003
ER
PT J
AU Gumbs, G
Iurov, A
Wu, JY
Lin, MF
Fekete, P
AF Gumbs, Godfrey
Iurov, Andrii
Wu, Jhao-Ying
Lin, M. F.
Fekete, Paula
TI Plasmon Excitations of Multi-layer Graphene on a Conducting Substrate
SO SCIENTIFIC REPORTS
LA English
DT Article
ID DIELECTRIC FUNCTION; METAL CONTACTS; SUPERLATTICE; SURFACE
AB We predict the existence of low-frequency nonlocal plasmons at the vacuum-surface interface of a superlattice of N graphene layers interacting with conducting substrate. We derive a dispersion function that incorporates the polarization function of both the graphene monolayers and the semi-infinite electron liquid at whose surface the electrons scatter specularly. We find a surface plasmon-polariton that is not damped by particle-hole excitations or the bulk modes and which separates below the continuum mini-band of bulk plasmon modes. The surface plasmon frequency of the hybrid structure always lies below omega(s)=p/root 2, the surface plasmon frequency of the conducting substrate. The intensity of this mode depends on the distance of the graphene layers from the conductor's surface, the energy band gap between valence and conduction bands of graphene monolayer and, most importantly, on the number of two-dimensional layers. For a sufficiently large number of layers (N greater than or similar to 7) the hybrid structure has no surface plasmon. The existence of plasmons with different dispersion relations indicates that quasiparticles with different group velocity may coexist for various ranges of wavelengths determined by the number of layers in the superlattice.
C1 [Gumbs, Godfrey] CUNY, Hunter Coll, Dept Phys & Astron, 695 Pk Ave, New York, NY 10065 USA.
[Iurov, Andrii] Univ New Mexico, Ctr High Technol Mat, Albuquerque, NM 87106 USA.
[Wu, Jhao-Ying; Lin, M. F.] Natl Cheng Kung Univ, Dept Phys, Tainan 701, Taiwan.
[Fekete, Paula] US Mil Acad, West Point, NY 10996 USA.
[Gumbs, Godfrey] Donostia Int Phys Ctr, P Manuel de Lardizabal 4, San Sebastian 20018, Spain.
RP Gumbs, G (reprint author), CUNY, Hunter Coll, Dept Phys & Astron, 695 Pk Ave, New York, NY 10065 USA.; Gumbs, G (reprint author), Donostia Int Phys Ctr, P Manuel de Lardizabal 4, San Sebastian 20018, Spain.
EM ggumbs@hunter.cuny.edu
RI DONOSTIA INTERNATIONAL PHYSICS CTR., DIPC/C-3171-2014
FU AFRL [FA 9453-13-1-0291]
FX This research was supported by contract #FA 9453-13-1-0291 of AFRL. We
are grateful to Danhong Huang for helpful discussions.
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U1 13
U2 41
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD FEB 17
PY 2016
VL 6
AR 21063
DI 10.1038/srep21063
PG 11
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DD9EW
UT WOS:000370229500002
PM 26883086
ER
PT J
AU Wang, CX
Granskog, MA
Hudson, SR
Gerland, S
Pavlov, AK
Perovich, DK
Nicolaus, M
AF Wang, Caixin
Granskog, Mats A.
Hudson, Stephen R.
Gerland, Sebastian
Pavlov, Alexey K.
Perovich, Donald K.
Nicolaus, Marcel
TI Atmospheric conditions in the central Arctic Ocean through the melt
seasons of 2012 and 2013: Impact on surface conditions and solar energy
deposition into the ice-ocean system
SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES
LA English
DT Article
DE central Arctic Ocean; surface condition; solar energy; atmospheric
condition; melt season
ID SEA-ICE; ALBEDO; BUDGET; ONSET; EVOLUTION; RADIATION; THICKNESS;
SNOWMELT; CYCLONE; COVER
AB Spectral Radiation Buoys and ice mass balance buoys were deployed on first-year ice near the North Pole in April 2012 and 2013, collecting in-band (350-800nm) solar radiation and ice and snow mass balance data over the complete summer melt seasons. With complementary European ERA-Interim reanalysis, National Centers for Environmental Prediction (NCEP) Climate forecast system version 2 (CFSv2) analysis and satellite passive microwave data, we examine the evolution of atmospheric and surface melt conditions in the two differing melt seasons. Prevailing atmospheric conditions contributed to a longer and more continuous melt season in summer 2012 than in 2013, which was corroborated by in situ observations. ERA-Interim reanalysis data showed that longwave radiation likely played a key role in delaying the snowmelt onset in 2013. The earlier melt onset in 2012 reduced the albedo, providing a positive ice-albedo feedback at a time when solar insolation was high. Due to earlier melt onset and later freeze-up in 2012, more solar heat was deposited into the ice-ocean system than in 2013. Summer 2013 was characterized by later melt onset, intermittent freezing events and an earlier fall freeze-up, resulting in considerably fewer effective days of surface melt and a higher average albedo. Calculations for idealized seasonal albedo evolution show that moving the melt onset just 1week earlier in mid-June increases the total absorbed solar radiation by nearly 14% for the summer season. Therefore, the earlier melt onset may have been one of the most important factors driving the more dramatic melt season in 2012 than 2013, though atmospheric circulation patterns, e.g., cyclone in early August 2012, likely contributed as well.
C1 [Wang, Caixin; Granskog, Mats A.; Hudson, Stephen R.; Gerland, Sebastian; Pavlov, Alexey K.] Norwegian Polar Res Inst, Fram Ctr, Tromso, Norway.
[Perovich, Donald K.] US Army, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA.
[Nicolaus, Marcel] Helmholtz Zentrum Polar & Meeresforsch, Alfred Wegener Inst, Bremerhaven, Germany.
RP Wang, CX (reprint author), Norwegian Polar Res Inst, Fram Ctr, Tromso, Norway.
EM caixin.wang@npolar.no
FU Research Council of Norway [193592, 221961/F20]; Fram Centre "Arctic
Ocean" flagship program through the SOLICE project; Centre for Ice,
Climate and Ecosystems (ICE) at NPI; European Commission [265863]
FX The authors are grateful to Marius Bratrein, Jago Wallenschus, Tor Ivan
Karlsen, and Kristen Fossan at Norwegian Polar Institute (NPI) for their
work with SRB design, construction, and deployments. We also wish to
acknowledge National Snow and Ice Data Center for providing SSMIS data,
ECWMF for ERA-Interim data, NCEP for CFSv2 data, and North Pole
Environmental Observatory (NPEO), University of Washington, USA, for
webcam photos. This study was supported by the Research Council of
Norway through projects AMORA (project 193592) and STASIS (project
221961/F20), by the Fram Centre "Arctic Ocean" flagship program through
the SOLICE project, by Centre for Ice, Climate and Ecosystems (ICE) at
NPI, and by ACCESS, a European project within the Ocean of Tomorrow call
of the European Commission Seventh Framework Programme (grant 265863).
Solar radiation data are available on request to data@npolar.no, and
snow and ice mass balance data can be found at
http://imb.erdc.dren.mil/buoysum.htm. Constructive comments from two
anonymous reviewers aided to improve the paper.
NR 67
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U1 3
U2 4
PU AMER GEOPHYSICAL UNION
PI WASHINGTON
PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA
SN 2169-897X
EI 2169-8996
J9 J GEOPHYS RES-ATMOS
JI J. Geophys. Res.-Atmos.
PD FEB 16
PY 2016
VL 121
IS 3
BP 1043
EP 1058
DI 10.1002/2015JD023712
PG 16
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA DF6QW
UT WOS:000371481700002
ER
PT J
AU Svenkeson, A
Glaz, B
Stanton, S
West, BJ
AF Svenkeson, Adam
Glaz, Bryan
Stanton, Samuel
West, Bruce J.
TI Spectral decomposition of nonlinear systems with memory
SO PHYSICAL REVIEW E
LA English
DT Article
ID FRACTIONAL CALCULUS; ANOMALOUS DIFFUSION; INSTANTANEOUS VELOCITY;
INTEGRAL-OPERATORS; EQUATION APPROACH; STRANGE KINETICS;
BROWNIAN-MOTION; KOOPMAN MODES; RANDOM-WALKS; FLOWS
AB We present an alternative approach to the analysis of nonlinear systems with long-term memory that is based on the Koopman operator and a Levy transformation in time. Memory effects are considered to be the result of interactions between a system and its surrounding environment. The analysis leads to the decomposition of a nonlinear system with memory into modes whose temporal behavior is anomalous and lacks a characteristic scale. On average, the time evolution of a mode follows a Mittag-Leffler function, and the system can be described using the fractional calculus. The general theory is demonstrated on the fractional linear harmonic oscillator and the fractional nonlinear logistic equation. When analyzing data from an ill-defined (black-box) system, the spectral decomposition in terms of Mittag-Leffler functions that we propose may uncover inherent memory effects through identification of a small set of dynamically relevant structures that would otherwise be obscured by conventional spectral methods. Consequently, the theoretical concepts we present may be useful for developing more general methods for numerical modeling that are able to determine whether observables of a dynamical system are better represented by memoryless operators, or operators with long-term memory in time, when model details are unknown.
C1 [Svenkeson, Adam; Glaz, Bryan] Army Res Lab, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA.
[Stanton, Samuel] Army Res Off, Engn Sci Directorate, Res Triangle Pk, NC 27709 USA.
[West, Bruce J.] Army Res Off, Informat Sci Directorate, Res Triangle Pk, NC 27709 USA.
RP Svenkeson, A (reprint author), Army Res Lab, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA.
NR 75
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Z9 0
U1 8
U2 11
PU AMER PHYSICAL SOC
PI COLLEGE PK
PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA
SN 2470-0045
EI 2470-0053
J9 PHYS REV E
JI Phys. Rev. E
PD FEB 16
PY 2016
VL 93
IS 2
AR 022211
DI 10.1103/PhysRevE.93.022211
PG 10
WC Physics, Fluids & Plasmas; Physics, Mathematical
SC Physics
GA DD9LY
UT WOS:000370248300010
PM 26986335
ER
PT J
AU Obaldia, N
Dow, GS
Gerena, L
Kyle, D
Otero, W
Mantel, PY
Baro, N
Daniels, R
Mukherjee, A
Childs, LM
Buckee, C
Duraisingh, MT
Volkman, SK
Wirth, DF
Marti, M
AF Obaldia, Nicanor, III
Dow, Geoffrey S.
Gerena, Lucia
Kyle, Dennis
Otero, William
Mantel, Pierre-Yves
Baro, Nicholas
Daniels, Rachel
Mukherjee, Angana
Childs, Lauren M.
Buckee, Caroline
Duraisingh, Manoj T.
Volkman, Sarah K.
Wirth, Dyann F.
Marti, Matthias
TI Altered drug susceptibility during host adaptation of a Plasmodium
falciparum strain in a non-human primate model
SO SCIENTIFIC REPORTS
LA English
DT Article
ID AOTUS-LEMURINUS-LEMURINUS; IN-VITRO; ARTEMISININ RESISTANCE; COMBINATION
THERAPY; ANTIMALARIAL-DRUGS; MALARIA; MEFLOQUINE; ARTESUNATE; MONKEYS;
GENE
AB Infections with Plasmodium falciparum, the most pathogenic of the Plasmodium species affecting man, have been reduced in part due to artemisinin-based combination therapies. However, artemisinin resistant parasites have recently emerged in South-East Asia. Novel intervention strategies are therefore urgently needed to maintain the current momentum for control and elimination of this disease. In the present study we characterize the phenotypic and genetic properties of the multi drug resistant (MDR) P. falciparum Thai C2A parasite strain in the non-human Aotus primate model, and across multiple passages. Aotus infections with C2A failed to clear upon oral artesunate and mefloquine treatment alone or in combination, and ex vivo drug assays demonstrated reduction in drug susceptibility profiles in later Aotus passages. Further analysis revealed mutations in the pfcrt and pfdhfr loci and increased parasite multiplication rate (PMR) across passages, despite elevated pfmdr1 copy number. Altogether our experiments suggest alterations in parasite population structure and increased fitness during Aotus adaptation. We also present data of early treatment failures with an oral artemisinin combination therapy in a pre-artemisinin resistant P. falciparum Thai isolate in this animal model.
C1 [Obaldia, Nicanor, III; Mantel, Pierre-Yves; Baro, Nicholas; Daniels, Rachel; Mukherjee, Angana; Duraisingh, Manoj T.; Volkman, Sarah K.; Wirth, Dyann F.; Marti, Matthias] Harvard Univ, Dept Immunol & Infect Dis, TH Chan Sch Publ Hlth, Boston, MA 02115 USA.
[Dow, Geoffrey S.; Gerena, Lucia] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Kyle, Dennis] Univ S Florida, Dept Global Hlth, Tampa, FL USA.
[Obaldia, Nicanor, III; Otero, William] Trop Med Res Inst Conmemorativo Gorgas Estudios S, Ctr Evaluat Antimalarial Drugs & Vaccines, Panama City, Panama.
[Childs, Lauren M.; Buckee, Caroline] Ctr Communicable Dis Dynam, Boston, MA USA.
[Childs, Lauren M.; Buckee, Caroline] Harvard Univ, TH Chan Sch Publ Hlth, Boston, MA 02115 USA.
[Childs, Lauren M.; Buckee, Caroline] Harvard Univ, Dept Epidemiol, TH Chan Sch Publ Hlth, Boston, MA 02115 USA.
[Volkman, Sarah K.; Wirth, Dyann F.] Broad Inst MIT & Harvard, Cambridge, MA USA.
[Volkman, Sarah K.] Simmons Coll, Sch Nursing & Hlth Sci, Boston, MA 02115 USA.
RP Obaldia, N; Marti, M (reprint author), Harvard Univ, Dept Immunol & Infect Dis, TH Chan Sch Publ Hlth, Boston, MA 02115 USA.; Obaldia, N (reprint author), Trop Med Res Inst Conmemorativo Gorgas Estudios S, Ctr Evaluat Antimalarial Drugs & Vaccines, Panama City, Panama.
EM nobaldia@hsph.harvard.edu; mmarti@hsph.harvard.edu
OI Childs, Lauren/0000-0003-3904-3895
FU USAMDA contract [W81XWH-07-C-044]; SENACYT-IFHARU Panama doctoral
fellowship; Sistema Nacional de Investigacion of Panama (SNI);
Department of Immunology and Infectious Diseases, Harvard T.H. Chan
School of Public Health, Boston, MA, USA; National Institute of General
Medical Sciences [U54GM088558]
FX The authors wish to thank the Directors of the Gorgas Memorial Institute
in Panama City, Drs. Jorge Motta and Nestor Sosa; Gines Sanchez and
Gladys Calvino at Tropical Medicine Research in Panama City for
administrative support; Maritza Brewer for secretarial assistance;
Camilo Marin, Temistocles Gonzales and the animal care takers for their
assistance with animal handling and care. We thank Katelyn Durfee for
help with the molecular barcoding and drug resistance marker typing and
Courtney Edison for help with the kelch13 propeller domain sequencing.
This work was supported in part by a USAMDA contract W81XWH-07-C-044, a
SENACYT-IFHARU Panama doctoral fellowship to Nicanor Obaldia III, the
Sistema Nacional de Investigacion of Panama (SNI) and the Department of
Immunology and Infectious Diseases, Harvard T.H. Chan School of Public
Health, Boston, MA, USA. LC and COB were supported by award number
U54GM088558 from the National Institute of General Medical Sciences. The
content is solely the responsibility of the authors and does not
necessarily represent the official views of the National Institute of
General Medical Sciences or the National Institutes of Health.
NR 52
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PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD FEB 16
PY 2016
VL 6
AR 21216
DI 10.1038/srep21216
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DD9DJ
UT WOS:000370225600001
PM 26880111
ER
PT J
AU Salje, H
Cauchemez, S
Alera, MT
Rodriguez-Barraguer, I
Thaisomboonsuk, B
Srikiatkhachorn, A
Lago, CB
Villa, D
Klungthong, C
Tac-An, IA
Fernandez, S
Velasco, JM
Roque, VG
Nisalak, A
Macareo, LR
Levy, JW
Cummings, D
Yoon, IK
AF Salje, Henrik
Cauchemez, Simon
Alera, Maria Theresa
Rodriguez-Barraguer, Isabel
Thaisomboonsuk, Butsaya
Srikiatkhachorn, Anon
Lago, Catherine B.
Villa, Daisy
Klungthong, Chonticha
Tac-An, Ilya A.
Fernandez, Stefan
Velasco, John Mark
Roque, Vito G., Jr.
Nisalak, Ananda
Macareo, Louis R.
Levy, Jens W.
Cummings, Derek
Yoon, In-Kyu
TI Reconstruction of 60 Years of Chikungunya Epidemiology in the
Philippines Demonstrates Episodic and Focal Transmission
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
DE chikungunya; epidemiology; Philippines; modeling; serological study
ID VIRUS; DENGUE; PREVALENCE; ANTIBODIES; INFECTION; DYNAMICS; DISEASE;
SPREAD; MODEL
AB Proper understanding of the long-term epidemiology of chikungunya has been hampered by poor surveillance. Outbreak years are unpredictable and cases often misdiagnosed. Here we analyzed age-specific data from 2 serological studies (from 1973 and 2012) in Cebu, Philippines, to reconstruct both the annual probability of infection and population-level immunity over a 60-year period (1952-2012). We also explored whether seroconversions during 2012-2013 were spatially clustered. Our models identified 4 discrete outbreaks separated by an average delay of 17 years. On average, 23% (95% confidence interval [CI], 16%-37%) of the susceptible population was infected per outbreak, with >50% of the entire population remaining susceptible at any point. Participants who seroconverted during 2012-2013 were clustered at distances of <230 m, suggesting focal transmission. Large-scale outbreaks of chikungunya did not result in sustained multiyear transmission. Nevertheless, we estimate that >350 000 infections were missed by surveillance systems. Serological studies could supplement surveillance to provide important insights on pathogen circulation.
C1 [Salje, Henrik; Rodriguez-Barraguer, Isabel; Cummings, Derek] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
[Srikiatkhachorn, Anon] Univ Massachusetts, Sch Med, Dept Med, Div Infect Dis & Immunol, Worcester, MA USA.
[Cummings, Derek] Univ Florida, Dept Biol, Gainesville, FL USA.
[Salje, Henrik; Cauchemez, Simon] Inst Pasteur, Math Modeling Unit, Paris, France.
[Alera, Maria Theresa; Lago, Catherine B.; Velasco, John Mark] Armed Forces Res Inst Med Sci, Virol Res Unit, Cebu, Philippines.
[Villa, Daisy; Tac-An, Ilya A.] Cebu City Hlth Dept, Cebu, Philippines.
[Roque, Vito G., Jr.] Natl Epidemiol Ctr, Dept Hlth, Manila, Philippines.
[Thaisomboonsuk, Butsaya; Klungthong, Chonticha; Fernandez, Stefan; Nisalak, Ananda; Macareo, Louis R.; Levy, Jens W.; Yoon, In-Kyu] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand.
[Yoon, In-Kyu] Int Vaccine Inst, Seoul, South Korea.
RP Salje, H (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, 615 N Wolfe St Rm E6008, Baltimore, MD 21205 USA.
EM hsalje@jhu.edu
OI Salje, Henrik/0000-0003-3626-4254
FU National Institutes of Health [R01 AI102939-01A1]; Armed Forces Health
Surveillance Center-Global Emerging Infections Surveillance and Response
System [P0149 14 AF]
FX This work was supported by the National Institutes of Health (grant R01
AI102939-01A1) and the Armed Forces Health Surveillance Center-Global
Emerging Infections Surveillance and Response System (grant P0149 14
AF).
NR 30
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U1 0
U2 5
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1899
EI 1537-6613
J9 J INFECT DIS
JI J. Infect. Dis.
PD FEB 15
PY 2016
VL 213
IS 4
BP 604
EP 610
DI 10.1093/infdis/jiv470
PG 7
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA DG9XS
UT WOS:000372437700017
PM 26410592
ER
PT J
AU Wu, XW
Darlington, DN
Cap, AP
AF Wu, Xiaowu
Darlington, Daniel N.
Cap, Andrew P.
TI Procoagulant and fibrinolytic activity after polytrauma in rat
SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE
PHYSIOLOGY
LA English
DT Article
DE thrombin; plasmin; fibrinolysis; coagulation; hemorrhage
ID ACUTE TRAUMATIC COAGULOPATHY; ACTIVATED PROTEIN-C; FACTOR-VIII-C;
TRANEXAMIC ACID; FACTOR-VA; PLASMIN; HYPERFIBRINOLYSIS; COAGULATION;
INACTIVATION; THROMBOMODULIN
AB The purpose of this study was to determine whether trauma-induced coagulopathy is due to changes in 1) thrombin activity, 2) plasmin activity, and/or 3) factors that stimulate or inhibit thrombin or plasmin. Sprague-Dawley rats were anesthetized with 1-2% isoflurane/100% oxygen, and their left femoral artery and vein were cannulated. Polytrauma included right femur fracture, and damage to the small intestines, the left and medial liver lobes, and right leg skeletal muscle. Rats were then bled 40% of blood volume. Plasma samples were taken before trauma, and at 30, 60, 120, and 240 min. Polytrauma and hemorrhage led to a significant fall in prothrombin levels. However, circulating thrombin activity did not change significantly over time. Antithrombin III and alpha 2 macroglobulin fell significantly by 2 h, then rose by 4 h. Soluble thrombomodulin was significantly elevated over the 4 h. Circulating plasmin activity, plasminogen, and D-dimers were elevated for the entire 4 h. Tissue plasminogen activator (tPA) was elevated at 30 min, then decreased below baseline levels after 1 h. Plasminogen activator inhibitor-1 was significantly elevated at 2-4 h. Neither tissue factor pathway inhibitor nor thrombin activatable fibrinolysis inhibitor changed significantly over time. The levels of prothrombin and plasminogen were 30-100 times higher than their respective active enzymes. Polytrauma and hemorrhage in rats lead to a fibrinolytic coagulopathy, as demonstrated by an elevation in plasmin activity, D-dimers, and tPA. These results are consistent with the observed clinical benefit of tranexamic acid in trauma patients.
C1 US Army Inst Surg Res, Blood Res, Ft Sam Houston, TX 78234 USA.
Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX 78229 USA.
RP Wu, XW (reprint author), US Army Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.
EM xiaowu.wu.civ@mail.mil
FU U.S. Army Medical Research Material Command
FX This study was funded by the U.S. Army Medical Research Material
Command.
NR 38
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U1 2
U2 7
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6119
EI 1522-1490
J9 AM J PHYSIOL-REG I
JI Am. J. Physiol.-Regul. Integr. Comp. Physiol.
PD FEB 15
PY 2016
VL 310
IS 4
BP R323
EP R329
DI 10.1152/ajpregu.00401.2015
PG 7
WC Physiology
SC Physiology
GA DD7SZ
UT WOS:000370125700002
PM 26632604
ER
PT J
AU Seo, M
Yamaguchi, H
Mohite, AD
Boubanga-Tombet, S
Blancon, JC
Najmaei, S
Ajayan, PM
Lou, J
Taylor, AJ
Prasankumar, RP
AF Seo, Minah
Yamaguchi, Hisato
Mohite, Aditya D.
Boubanga-Tombet, Stephane
Blancon, Jean-Christophe
Najmaei, Sina
Ajayan, Pulickel M.
Lou, Jun
Taylor, Antoinette J.
Prasankumar, Rohit P.
TI Ultrafast Optical Microscopy of Single Monolayer Molybdenum Disulfide
Flakes
SO SCIENTIFIC REPORTS
LA English
DT Article
ID MONO LAYER MOS2; INTEGRATED-CIRCUITS; CARRIER DYNAMICS; NANOWIRES;
RECOMBINATION; PHOTOLUMINESCENCE; SPECTROSCOPY; NANOSHEETS; EXCITONS;
DEFECTS
AB We have performed ultrafast optical microscopy on single flakes of atomically thin CVD-grown molybdenum disulfide, using non-degenerate femtosecond pump-probe spectroscopy to excite and probe carriers above and below the indirect and direct band gaps. These measurements reveal the influence of layer thickness on carrier dynamics when probing near the band gap. Furthermore, fluencedependent measurements indicate that carrier relaxation is primarily influenced by surface-related defect and trap states after above-bandgap photoexcitation. The ability to probe femtosecond carrier dynamics in individual flakes can thus give much insight into light-matter interactions in these twodimensional nanosystems.
C1 [Seo, Minah; Boubanga-Tombet, Stephane; Taylor, Antoinette J.; Prasankumar, Rohit P.] Los Alamos Natl Lab, Ctr Integrated Nanotechnol, POB 1663, Los Alamos, NM 87545 USA.
[Seo, Minah] Korea Inst Sci & Technol, Sensor Syst Res Ctr, Seoul, South Korea.
[Yamaguchi, Hisato; Mohite, Aditya D.] Los Alamos Natl Lab, Mat Phys & Applicat Div, Mat Synth & Integrated Devices, POB 1663, Los Alamos, NM 87545 USA.
[Blancon, Jean-Christophe] Los Alamos Natl Lab, Div Chem, Phys Chem & Appl Spect, POB 1663, Los Alamos, NM 87545 USA.
[Najmaei, Sina; Ajayan, Pulickel M.; Lou, Jun] Rice Univ, Dept Mat Sci & NanoEngn, Houston, TX 77005 USA.
[Boubanga-Tombet, Stephane] Tohoku Univ, Elect Commun Res Inst, Aoba Ku, 2-1-1 Katahira, Sendai, Miyagi 9808577, Japan.
[Najmaei, Sina] US Army, Res Labs, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
RP Prasankumar, RP (reprint author), Los Alamos Natl Lab, Ctr Integrated Nanotechnol, POB 1663, Los Alamos, NM 87545 USA.
EM rpprasan@lanl.gov
RI Yamaguchi, Hisato/C-5571-2008; Boubanga Tombet, Stephane/E-9985-2015
OI Blancon, Jean-Christophe/0000-0002-3833-5792; Yamaguchi,
Hisato/0000-0002-6703-8826;
FU Department of Energy, Office of Basic Energy Sciences, Division of
Materials Science and Engineering; U.S. Department of Energy (DOE),
Office of Basic Energy Sciences (BES); LANL Laboratory Directed Research
and Development Program; U.S. Department of Energy [DE-AC52-06NA25396];
KIST institutional programs [2E25382]
FX This work was primarily supported by the Department of Energy, Office of
Basic Energy Sciences, Division of Materials Science and Engineering,
and performed in part at the Center for Integrated Nanotechnologies
(CINT), a U.S. Department of Energy (DOE), Office of Basic Energy
Sciences (BES) user facility. Additional support was provided by the
LANL Laboratory Directed Research and Development Program. Los Alamos
National Laboratory, an affirmative action equal opportunity employer,
is operated by Los Alamos National Security, LLC, for the National
Nuclear Security administration of the U.S. Department of Energy under
contract no. DE-AC52-06NA25396. This work was also partially supported
by the KIST institutional programs (Project No. 2E25382). We thank Jim
Werner and Doug Shepherd of LANL for their support in PL image
measurements.
NR 41
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U1 15
U2 50
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD FEB 15
PY 2016
VL 6
AR 21601
DI 10.1038/srep21601
PG 7
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DD6OL
UT WOS:000370043400001
PM 26876194
ER
PT J
AU Tabandeh-Khorshid, M
Ferguson, JB
Schultz, BF
Kim, CS
Cho, K
Rohatgi, PK
AF Tabandeh-Khorshid, Meysam
Ferguson, J. B.
Schultz, Benjamin F.
Kim, Chang-Soo
Cho, Kyu
Rohatgi, Pradeep K.
TI Strengthening mechanisms of graphene- and Al2O3-reinforced aluminum
nanocomposites synthesized by room temperature milling
SO MATERIALS & DESIGN
LA English
DT Article
DE Nanostructured materials; Metal matrix composites; X-ray diffraction;
Powder metallurgy; Hardness measurement
ID METAL-MATRIX NANOCOMPOSITES; FIB-SEM SYSTEM; YIELD STRENGTH; AL-ALLOY;
COMPOSITES; BEHAVIOR; MICROSTRUCTURE; MG; STRESS; REINFORCEMENT
AB Powder metallurgy (PM) is a widely used processing method to synthesize ultrafine and nanometric grain -sized alloys and composites. While most previous work on synthesizing nanocrystalline (NC) metal-matrix nanocomposites (MMNCs) has used cryomilling technique with liquid nitrogen and stearic acid followed by high temperature/high vacuum drying, we employed an advanced room temperature method that involves milling in ethanol followed by low temperature atmospheric drying - a much less expensive process. To understand the strengthening mechanisms of MMNCs, pure NC Al was reinforced with varying concentrations of Al2O3 nanoparticles (NPs) and graphene nanoplatelets (GNPs). The results show that i) room temperature milling in ethanol followed by a relatively low temperature drying treatment can produce NC Al and NC Al MMNCs with grain sizes comparable to materials produced by cryomilling, ii) grain boundary strengthening as described by the Hall-Petch relation accounts for the strength of Al-Al2O3 MMNCs, and iii) grain boundary strengthening and solute strengthening seem to account for the strength in Al-GNP MMNCs. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Tabandeh-Khorshid, Meysam; Ferguson, J. B.; Schultz, Benjamin F.; Kim, Chang-Soo; Rohatgi, Pradeep K.] Univ Wisconsin, Mat Sci & Engn Dept, Milwaukee, WI 53211 USA.
[Cho, Kyu] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
RP Tabandeh-Khorshid, M (reprint author), Univ Wisconsin, Mat Sci & Engn Dept, Milwaukee, WI 53211 USA.
EM meysam@uwm.edu
FU U.S. Army Research Laboratory [W911NF-08-2-0014, W911NF-15-2-0005]
FX This material is based upon work supported by the U.S. Army Research
Laboratory under Cooperative Agreements nos. W911NF-08-2-0014 and
W911NF-15-2-0005. The views, opinions, and conclusions made in this
document are those of the authors and should not be interpreted as
representing the official policies, either expressed or implied, of the
Army Research Laboratory or the U.S. Government. The U.S. Government is
authorized to reproduce and distribute reprints for Government purposes
notwithstanding any copyright notation herein.
NR 43
TC 4
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U1 16
U2 51
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-1275
EI 1873-4197
J9 MATER DESIGN
JI Mater. Des.
PD FEB 15
PY 2016
VL 92
BP 79
EP 87
DI 10.1016/j.matdes.2015.12.007
PG 9
WC Materials Science, Multidisciplinary
SC Materials Science
GA DC4LH
UT WOS:000369191900010
ER
PT J
AU Bautista, CT
Wurapa, E
Sateren, WB
Morris, S
Hollingsworth, B
Sanchez, JL
AF Bautista, Christian T.
Wurapa, Eyako
Sateren, Warren B.
Morris, Sara
Hollingsworth, Bruce
Sanchez, Jose L.
TI Bacterial vaginosis: a synthesis of the literature on etiology,
prevalence, risk factors, and relationship with chlamydia and gonorrhea
infections
SO MILITARY MEDICAL RESEARCH
LA English
DT Review
DE Bacterial vaginosis; Chlamydia; Gonorrhea; Military; Epidemiology; STI
ID SEXUALLY-TRANSMITTED-DISEASES; HAEMOPHILUS-VAGINALIS;
GARDNERELLA-VAGINALIS; NONSPECIFIC VAGINITIS; NEISSERIA-GONORRHOEAE;
PREGNANT-WOMEN; TRACHOMATIS INFECTIONS; GENITAL-INFECTION; SEX WORKERS;
GRAM STAIN
AB Bacterial vaginosis (BV) is a common vaginal disorder in women of reproductive age. Since the initial work of Leopoldo in 1953 and Gardner and Dukes in 1955, researchers have not been able to identify the causative etiologic agent of BV. There is increasing evidence, however, that BV occurs when Lactobacillus spp., the predominant species in healthy vaginal flora, are replaced by anaerobic bacteria, such as Gardenella vaginalis, Mobiluncus curtisii, M. mulieris, other anaerobic bacteria and/or Mycoplasma hominis. Worldwide, it estimated that 20-30 % of women of reproductive age attending sexually transmitted infection (STI) clinics suffer from BV, and that its prevalence can be as high as 50-60 % in high-risk populations (e.g., those who practice commercial sex work (CSW). Epidemiological data show that women are more likely to report BV if they: 1) have had a higher number of lifetime sexual partners; 2) are unmarried; 3) have engaged in their first intercourse at a younger age; 4) have engaged in CSW, and 5) practice regular douching. In the past decade, several studies have provided evidence on the contribution of sexual activity to BV. However, it is difficult to state that BV is a STI without being able to identify the etiologic agent. BV has also emerged as a public health problem due to its association with other STIs, including: human immunodeficiency virus (HIV), herpes simplex virus type 2 (HSV-2), Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG). The most recent evidence on the association between BV and CT/NG infection comes from two secondary analyses of cohort data conducted among women attending STI clinics. Based on these studies, women with BV had a 1.8 and 1.9-fold increased risk for NG and CT infection, respectively. Taken together, BV is likely a risk factor or at least an important contributor to subsequent NG or CT infection in high-risk women. Additional research is required to determine whether this association is also present in other low-risk sexually active populations, such as among women in the US military. It is essential to conduct large scale cross-sectional or population-based case-control studies to investigate the role of BV as a risk factor for CT/NG infections. These studies could lead to the development of interventions aimed at reducing the burden associated with bacterial STIs worldwide.
C1 [Bautista, Christian T.; Morris, Sara; Hollingsworth, Bruce] Univ Lancaster, Div Hlth Res, Lancaster, England.
[Wurapa, Eyako; Sateren, Warren B.] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Sanchez, Jose L.] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD USA.
[Sanchez, Jose L.] Cherokee Nation Technol Solut, Silver Spring, MD USA.
RP Bautista, CT (reprint author), Univ Lancaster, Div Hlth Res, Lancaster, England.
EM m.bautista@lancaster.ac.uk
NR 95
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U1 10
U2 12
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 2054-9369
J9 MILITARY MED RES
JI MILITARY MED. RES.
PD FEB 13
PY 2016
VL 3
AR UNSP 4
DI 10.1186/s40779-016-0074-5
PG 10
WC Medicine, General & Internal
SC General & Internal Medicine
GA DU3AW
UT WOS:000382084100001
PM 26877884
ER
PT J
AU Mullins, AB
Despain, KE
Wallace, SM
Honnold, CL
Lent, EM
AF Mullins, Anna B.
Despain, Kenneth E.
Wallace, Shannon M.
Honnold, Cary L.
Lent, Emily May
TI Testicular effects of 3-nitro-1,2,4-triazol-5-one (NTO) in mice when
exposed orally
SO TOXICOLOGY MECHANISMS AND METHODS
LA English
DT Article
DE 932-64-9; BALB; c; degeneration; IMX 101; insensitive munitions; mice;
testicular effects
ID RATS; TESTIS; PHTHALATE; TOXICITY; HISTOPATHOLOGY; ATROPHY; ETHER
AB 3-Nitro-1,2,4-triazol-5-one (NTO) is currently being investigated in the development of insensitive munitions. Rats orally exposed to NTO have demonstrated testicular toxicity in both subacute and subchronic studies; however, toxicity has not been verified in mice. Also, previous studies have not demonstrated the nature of NTO-induced testicular toxicity due to the prolonged dosing regimen utilized and effects of maturation depletion. In this study, a time-course design was used and the earliest pathological changes in testes of adult BALB/c mice orally dosed with NTO in corn oil suspensions at 0, 500 or 1000mg/kg-day NTO for 1, 3, 7 or 14 d were evaluated. The earliest NTO-induced testicular changes occurred in the 1000mg/kg-day group at day 7 and the 500mg/kg-day group at day 14 as evident by the presence of bi- and multinucleated giant cells (MNGCs) of almost all spermatids in an isolated stage II-III tubule/step 2-3 and a stage IX tubule/step 9 in the 1000 and 500mg/kg-day groups, respectively. Testicular toxicity was characterized by degeneration and the presence of bi- and MNGCs of spermatids (stages II-III and IX), which progressed to additional germ cell degeneration as dosing duration increased. Occasional step 16 spermatid retention was also noted in stage XII and I tubules in the day 14, 1000mg/kg-day group. These data indicate that NTO is a testicular toxicant in mice and that spermatids are the most sensitive cell. The presence of retained spermatids warrants further investigation regarding NTO's role as a direct Sertoli cell toxicant.
C1 [Mullins, Anna B.; Despain, Kenneth E.; Wallace, Shannon M.; Honnold, Cary L.] Walter Reed Army Inst Res, Vet Serv Program, Naval Med Res Ctr, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
[Lent, Emily May] US Army Publ Hlth Command, Army Inst Publ Hlth, Aberdeen Proving Ground, MD USA.
RP Mullins, AB (reprint author), Walter Reed Army Inst Res, Vet Serv Program, Naval Med Res Ctr, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM anna.b.mullins2.mil@mail.mil
FU Strategic Environmental Research and Development Program (SERDP)
[ER-2223]
FX This work was supported by funding from the Strategic Environmental
Research and Development Program (SERDP Project ER-2223). The authors
declare no competing interests. Material has been reviewed by the Walter
Reed Army Institute of Research. There is no objection to its
presentation and/or publication. The opinions or assertions contained
herein are the private views of the author, and are not to be construed
as official, or as reflecting true view of the Department of the Army or
the Department of Defense.
NR 25
TC 0
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U1 1
U2 4
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1537-6516
EI 1537-6524
J9 TOXICOL MECH METHOD
JI Toxicol. Mech. Methods
PD FEB 12
PY 2016
VL 26
IS 2
BP 97
EP 103
DI 10.3109/15376516.2015.1118175
PG 7
WC Toxicology
SC Toxicology
GA DI5GX
UT WOS:000373528000004
PM 26804465
ER
PT J
AU Belle, A
Ansari, S
Spadafore, M
Convertino, VA
Ward, KR
Derksen, H
Najarian, K
AF Belle, Ashwin
Ansari, Sardar
Spadafore, Maxwell
Convertino, Victor A.
Ward, Kevin R.
Derksen, Harm
Najarian, Kayvan
TI A Signal Processing Approach for Detection of Hemodynamic Instability
before Decompensation
SO PLOS ONE
LA English
DT Article
ID HEART-RATE-VARIABILITY; COMPLEX WAVELETS; BLOOD-PRESSURE; HEMORRHAGE;
MORTALITY
AB Advanced hemodynamic monitoring is a critical component of treatment in clinical situations where aggressive yet guided hemodynamic interventions are required in order to stabilize the patient and optimize outcomes. While there are many tools at a physician's disposal to monitor patients in a hospital setting, the reality is that none of these tools allow hi-fidelity assessment or continuous monitoring towards early detection of hemodynamic instability. We present an advanced automated analytical system which would act as a continuous monitoring and early warning mechanism that can indicate pending decompensation before traditional metrics can identify any clinical abnormality. This system computes novel features or bio-markers from both heart rate variability (HRV) as well as the morphology of the electrocardiogram (ECG). To compare their effectiveness, these features are compared with the standard HRV based bio-markers which are commonly used for hemodynamic assessment. This study utilized a unique database containing ECG waveforms from healthy volunteer subjects who underwent simulated hypovolemia under controlled experimental settings. A support vector machine was utilized to develop a model which predicts the stability or instability of the subjects. Results showed that the proposed novel set of features outperforms the traditional HRV features in predicting hemodynamic instability.
C1 [Belle, Ashwin; Ansari, Sardar; Ward, Kevin R.; Najarian, Kayvan] Univ Michigan, Dept Emergency Med, Ann Arbor, MI 48109 USA.
[Belle, Ashwin; Ansari, Sardar; Ward, Kevin R.; Derksen, Harm; Najarian, Kayvan] Univ Michigan, Michigan Ctr Integrat Res Crit Care, Ann Arbor, MI 48109 USA.
[Derksen, Harm] Univ Michigan, Dept Math, Ann Arbor, MI 48109 USA.
[Najarian, Kayvan] Univ Michigan, Dept Computat Med & Bioinformat, Ann Arbor, MI 48109 USA.
[Spadafore, Maxwell] Univ Michigan, Coll Literature Sci & Arts, Ann Arbor, MI 48109 USA.
[Convertino, Victor A.] US Army Inst Surg Res, Combat Casualty Care Res Program, San Antonio, TX USA.
RP Belle, A (reprint author), Univ Michigan, Dept Emergency Med, Ann Arbor, MI 48109 USA.; Belle, A (reprint author), Univ Michigan, Michigan Ctr Integrat Res Crit Care, Ann Arbor, MI 48109 USA.
EM bellea@med.umich.edu
FU U.S. Army Medical Research and Material Command Combat Casualty Care
Research Program [05-0033-02]
FX Initial work of this project was funded by: U.S. Army Medical Research
and Material Command Combat Casualty Care Research Program, Grant:
05-0033-02: KN KW. The authors had no role in the design of experimental
setup and data collection for the LBNP study. The LBNP study was
designed and data was collected by USASR which partially funded the
project in the early stages.
NR 39
TC 0
Z9 0
U1 1
U2 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 12
PY 2016
VL 11
IS 2
AR e0148544
DI 10.1371/journal.pone.0148544
PG 20
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DD6SI
UT WOS:000370054100035
PM 26871715
ER
PT J
AU Huang, YM
Rueda, LM
AF Huang, Yiau-Min
Rueda, Leopoldo M.
TI A pictorial key to the sections, groups, and species of the Aedes
(Diceromyia) in the Afrotropical Region (Diptera: Culicidae)
SO ZOOTAXA
LA English
DT Article
DE Culicidae; mosquitoes; identification key; Aedes; Africa
ID YELLOW-FEVER VIRUS; SOUTHEASTERN SENEGAL; CHIKUNGUNYA OUTBREAK; SOUTHERN
RHODESIA; FURCIFER-TAYLORI; MOSQUITOS; DENGUE-2; EPIDEMIC
AB Nine species of the subgenus Diceromyia Theobald of genus Aedes Meigen in the Afrotropical Region are treated in a pictorial key based on diagnostic morphological features. Images of the diagnostic morphological structures of the adult head, thorax, abdomen, leg and wing are included. The medical importance of the Furcifer Group species in Africa was briefly reviewed.
C1 [Huang, Yiau-Min] Smithsonian Inst, Dept Entomol, POB 37012,MSC C1109,MRC 534, Washington, DC 20013 USA.
[Rueda, Leopoldo M.] Walter Reed Army Inst Res, Entomol Branch, Walter Reed Biosystemat Unit, Silver Spring, MD 20910 USA.
[Rueda, Leopoldo M.] Smithsonian Inst, Walter Reed Biosystemat Unit, Museum Support Ctr, MRC 534,4210 Silver Hill Rd, Suitland, MD 20746 USA.
RP Huang, YM (reprint author), Smithsonian Inst, Dept Entomol, POB 37012,MSC C1109,MRC 534, Washington, DC 20013 USA.; Rueda, LM (reprint author), Walter Reed Army Inst Res, Entomol Branch, Walter Reed Biosystemat Unit, Silver Spring, MD 20910 USA.; Rueda, LM (reprint author), Smithsonian Inst, Walter Reed Biosystemat Unit, Museum Support Ctr, MRC 534,4210 Silver Hill Rd, Suitland, MD 20746 USA.
EM huangy@si.edu; ruedapol@si.edu
NR 35
TC 0
Z9 0
U1 0
U2 3
PU MAGNOLIA PRESS
PI AUCKLAND
PA PO BOX 41383, AUCKLAND, ST LUKES 1030, NEW ZEALAND
SN 1175-5326
EI 1175-5334
J9 ZOOTAXA
JI Zootaxa
PD FEB 11
PY 2016
VL 4079
IS 2
BP 281
EP 290
PG 10
WC Zoology
SC Zoology
GA DD7UC
UT WOS:000370128900009
PM 27396006
ER
PT J
AU Kiziltas, A
Nazari, B
Kiziltas, EE
Gardner, DJS
Han, Y
Rushing, TS
AF Kiziltas, Alper
Nazari, Behzad
Kiziltas, Esra Erbas
Gardner, Douglas J. S.
Han, Yousoo
Rushing, Todd S.
TI Cellulose NANOFIBER-polyethylene nanocomposites modified by polyvinyl
alcohol
SO JOURNAL OF APPLIED POLYMER SCIENCE
LA English
DT Article
DE cellulose and other wood products; manufacturing; rheology;
thermogravimetric analysis; thermoplastics
ID FILLED POLYPROPYLENE COMPOSITES; NYLON 6 COMPOSITES;
MECHANICAL-PROPERTIES; THERMAL-ANALYSIS; WHISKERS; WOOD;
ULTRASONICATION; ACID/CELLULOSE; NANOCRYSTALS; MORPHOLOGY
AB The uniform dispersion of cellulose nanofibers (CNFs) in non-polar polymer matrices is a primary problem to overcome in creating novel nanocomposites from these materials. The aim of this study was to produce CNF-polyethylene (PE) nanocomposites by melt compounding followed by injection molding to investigate the possibility of using polyvinyl alcohol (PVA) to improve the dispersion of CNF in the PE matrix. The tensile strength of CNF- filled composites was 17.4 MPa with the addition of 5 wt % CNF-PVA, which was 25% higher than the strength of neat PE. The tensile modulus of elasticity increased by 40% with 5% CNF-PVA addition. Flexural properties also significantly increased with increased CNF loading. Shear viscosity increased with increasing CNF content. The elastic moduli of the PE/CNF composites from rheological measurements were greater than those of the neat PE matrix because of the intrinsic rigidity of CNF. Melt creep compliance decreased by about 13% and 45% for the composites with 5 wt % CNF and 10 wt % CNF, respectively. It is expected that the PVA carrier system can contribute to the development of a process methodology to effectively disperse CNFs containing water in a polymer matrix. (c) 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 42933.
C1 [Kiziltas, Alper; Kiziltas, Esra Erbas; Gardner, Douglas J. S.; Han, Yousoo] Univ Maine, Adv Struct & Composites Ctr AEWC, Orono, ME 04469 USA.
[Kiziltas, Alper] Univ Bartin, Dept Forest Ind Engn, Fac Forestry, TR-74100 Bartin, Turkey.
[Nazari, Behzad] Univ Maine, Dept Chem Engn, Orono, ME 04469 USA.
[Kiziltas, Esra Erbas; Gardner, Douglas J. S.] Sci & Technol Res Council Turkey TUBITAK, TR-06100 Ankara, Turkey.
[Rushing, Todd S.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Kiziltas, A (reprint author), Univ Maine, Adv Struct & Composites Ctr AEWC, Orono, ME 04469 USA.
EM kiziltasalper@gmail.com
FU U.S. Army Engineer Research and Development Center [912HZ-07-2-0013];
Maine Agricultural and Forest Experiment Station (MAFES) project
[ME09615-08M]
FX The authors thank Chris West and Alex Nash for all of their hard work
for production, characterization and material properties of the polymer
nanocomposites. The authors also thank U.S. Army Engineer Research and
Development Center project 912HZ-07-2-0013 and the Maine Agricultural
and Forest Experiment Station (MAFES) project ME09615-08M. Permission to
publish was granted by Director, Geotechnical and Structures Laboratory,
at the U.S. Army Engineer Research and Development Center.
NR 55
TC 3
Z9 3
U1 10
U2 82
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-8995
EI 1097-4628
J9 J APPL POLYM SCI
JI J. Appl. Polym. Sci.
PD FEB 10
PY 2016
VL 133
IS 6
AR 42933
DI 10.1002/app.42933
PG 8
WC Polymer Science
SC Polymer Science
GA CX2JX
UT WOS:000365524100003
ER
PT J
AU Cho, JH
Gao, JX
AF Cho, Jin-Hee
Gao, Jianxi
TI Cyber War Game in Temporal Networks
SO PLOS ONE
LA English
DT Article
ID COMPLEX NETWORKS; INTERDEPENDENT NETWORKS
AB In a cyber war game where a network is fully distributed and characterized by resource constraints and high dynamics, attackers or defenders often face a situation that may require optimal strategies to win the game with minimum effort. Given the system goal states of attackers and defenders, we study what strategies attackers or defenders can take to reach their respective system goal state (i.e., winning system state) with minimum resource consumption. However, due to the dynamics of a network caused by a node's mobility, failure or its resource depletion over time or action(s), this optimization problem becomes NP-complete. We propose two heuristic strategies in a greedy manner based on a node's two characteristics: resource level and influence based on k-hop reachability. We analyze complexity and optimality of each algorithm compared to optimal solutions for a small-scale static network. Further, we conduct a comprehensive experimental study for a large-scale temporal network to investigate best strategies, given a different environmental setting of network temporality and density. We demonstrate the performance of each strategy under various scenarios of attacker/defender strategies in terms of win probability, resource consumption, and system vulnerability.
C1 [Cho, Jin-Hee] US Army Res Lab, Computat & Informat Sci Directorate, Adelphi, MD 20783 USA.
[Gao, Jianxi] Northeastern Univ, Ctr Complex Network Res, Boston, MA 02115 USA.
[Gao, Jianxi] Northeastern Univ, Dept Phys, Boston, MA 02115 USA.
RP Gao, JX (reprint author), Northeastern Univ, Ctr Complex Network Res, Boston, MA 02115 USA.; Gao, JX (reprint author), Northeastern Univ, Dept Phys, Boston, MA 02115 USA.
EM jianxi.gao@gmail.com
RI gao, jianxi/I-1300-2013; Gao, Jianxi/C-8494-2015
OI gao, jianxi/0000-0002-3952-208X; Gao, Jianxi/0000-0002-3952-208X
FU Army Research Laboratory via the Network Science Collaborative
Technology Alliance (NS CTA) program [W911NF-09-2-0053]; John Templeton
Foundation: Mathematical and Physical Sciences [PFI-777]; Defense Threat
Reduction Agency Basic Research [HDTRA1-10-1-0100]; European Commission
[FP7317532, 641191]; National Natural Science Foundation of China
[61374160, 71201132]
FX Research was, in part, for Dr. Jianxi Gao, sponsored by the Army
Research Laboratory via the Network Science Collaborative Technology
Alliance (NS CTA) program and was accomplished under Cooperative
Agreement Number W911NF-09-2-0053. The views and conclusions contained
in this document are those of the authors and should not be interpreted
as representing the official policies, either expressed or implied, of
the Army Research Laboratory or the U.S. Government. Dr. Jianxi Gao also
acknowledges the support of the John Templeton Foundation: Mathematical
and Physical Sciences grant number PFI-777; The Defense Threat Reduction
Agency Basic Research Grant No. HDTRA1-10-1-0100; European Commission
grant numbers FP7317532 (MULTIPLEX) and 641191 (CIMPLEX); and the
National Natural Science Foundation of China (Grants 61374160 and
71201132). The funders had no role in study design, data collection and
analysis, decision to publish, or preparation of the manuscript.
NR 34
TC 0
Z9 0
U1 1
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 9
PY 2016
VL 11
IS 2
AR e0148674
DI 10.1371/journal.pone.0148674
PG 16
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DD6MN
UT WOS:000370038400063
PM 26859840
ER
PT J
AU Maneerattanasak, S
Gosi, P
Krudsood, S
Tongshoob, J
Lanteri, CA
Snounou, G
Khusmith, S
AF Maneerattanasak, Sarunya
Gosi, Panita
Krudsood, Srivicha
Tongshoob, Jarinee
Lanteri, Charlotte A.
Snounou, Georges
Khusmith, Srisin
TI Genetic diversity among Plasmodium vivax isolates along the Thai-Myanmar
border of Thailand
SO MALARIA JOURNAL
LA English
DT Article
DE Plasmodium vivax; Genetic diversity; Multiplicity; Pvcsp; Pvmsp1;
Pvmsp3a; Thailand
ID MEROZOITE SURFACE PROTEIN-1; CIRCUMSPOROZOITE PROTEIN; REDUCED RISK;
MALARIA; INFECTIONS; POLYMORPHISM; CHLOROQUINE; VARIANTS; CHILDREN;
MARKERS
AB Background: Knowledge of the population genetics and transmission dynamics of Plasmodium vivax is crucial in predicting the emergence of drug resistance, relapse pattern and novel parasite phenotypes, all of which are relevant to the control of vivax infections. The aim of this study was to analyse changes in the genetic diversity of P. vivax genes from field isolates collected at different times along the Thai-Myanmar border.
Methods: Two hundred and fifty-four P. vivax isolates collected during two periods 10 years apart along the Thai-Myanmar border were analysed. The parasites were genotyped by nested-PCR and PCR-RFLP targeting selected polymorphic loci of Pvmsp1, Pvmsp3a and Pvcsp genes.
Results: The total number of distinguishable allelic variants observed for Pvcsp, Pvmsp1, and Pvmsp3a was 17, 7 and 3, respectively. High genetic diversity was observed for Pvcsp (H-E = 0.846) and Pvmsp1 (H-E = 0.709). Of the 254 isolates, 4.3 and 14.6 % harboured mixed Pvmsp1 and Pvcsp genotypes with a mean multiplicity of infection (MOI) of 1.06 and 1.15, respectively. The overall frequency of multiple genotypes was 16.9 %. When the frequencies of allelic variants of each gene during the two distinct periods were analysed, significant differences were noted for Pvmsp1 (P = 0.018) and the Pvcsp (P = 0.033) allelic variants.
Conclusion: Despite the low malaria transmission levels in Thailand, P. vivax population exhibit a relatively high degree of genetic diversity along the Thai-Myanmar border of Thailand, in particular for Pvmsp1 and Pvcsp, with indication of geographic and temporal variation in frequencies for some variants. These results are of relevance to monitoring the emergence of drug resistance and to the elaboration of measures to control vivax malaria.
C1 [Maneerattanasak, Sarunya; Tongshoob, Jarinee; Khusmith, Srisin] Mahidol Univ, Fac Trop Med, Dept Microbiol & Immunol, 420-6 Rajvithi Rd, Bangkok 10400, Thailand.
[Gosi, Panita; Lanteri, Charlotte A.] US Army Mil Component, Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok, Thailand.
[Krudsood, Srivicha] Mahidol Univ, Fac Trop Med, Clin Malaria Res Unit, Bangkok, Thailand.
[Snounou, Georges] Univ Paris 06, Sorbonne Univ, UPMC UMRS CR7, F-75005 Paris, France.
[Snounou, Georges] CNRS ERL 8255, CIMI Paris, Inserm U1135, F-75013 Paris, France.
[Khusmith, Srisin] Mahidol Univ, Ctr Emerging & Neglected Infect Dis, Bangkok 10700, Thailand.
RP Khusmith, S (reprint author), Mahidol Univ, Fac Trop Med, Dept Microbiol & Immunol, 420-6 Rajvithi Rd, Bangkok 10400, Thailand.; Khusmith, S (reprint author), Mahidol Univ, Ctr Emerging & Neglected Infect Dis, Bangkok 10700, Thailand.
EM srisin.khu@mahidol.ac.th
FU Royal Golden Jubilee Ph.D. Program (RGJ) of the Thailand Research Fund
[PHD/0095/2554]; Office of Higher Education Commission, Ministry of
Education, Thailand; Faculty of Tropical Medicine, Mahidol University;
Mahidol University under the National Research Universities Initiative
FX We wish to thank Clinical Malaria Research Unit, Faculty of Tropical
Medicine, Mahidol University for providing stored blood samples. We
thank Somporn Krasaesub, Department of Administration, Armed Forces
Research Institute of Medical Sciences (AFRIMS), Bangkok, Thailand for
providing suggestions for data analysis. This study is supported by the
Royal Golden Jubilee Ph.D. Program (RGJ) of the Thailand Research Fund,
Grant No. PHD/0095/2554; the Office of Higher Education Commission,
Ministry of Education, Thailand, Mahidol University under the National
Research Universities Initiative; and the Faculty of Tropical Medicine,
Mahidol University.
NR 43
TC 1
Z9 1
U1 3
U2 11
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2875
J9 MALARIA J
JI Malar. J.
PD FEB 9
PY 2016
VL 15
AR 75
DI 10.1186/s12936-016-1136-6
PG 8
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA DC9VG
UT WOS:000369569100002
PM 26858120
ER
PT J
AU Xu, YF
Bailey, E
Spackman, E
Li, T
Wang, H
Long, LP
Baroch, JA
Cunningham, FL
Lin, XX
Jarman, RG
DeLiberto, TJ
Wan, XF
AF Xu, Yifei
Bailey, Elizabeth
Spackman, Erica
Li, Tao
Wang, Hui
Long, Li-Ping
Baroch, John A.
Cunningham, Fred L.
Lin, Xiaoxu
Jarman, Richard G.
DeLiberto, Thomas J.
Wan, Xiu-Feng
TI Limited Antigenic Diversity in Contemporary H7 Avian-Origin Influenza A
Viruses from North America
SO SCIENTIFIC REPORTS
LA English
DT Article
ID PATTERN-RECOGNITION RECEPTORS; PHYLOGENETIC ANALYSIS; LOW-PATHOGENICITY;
UNITED-STATES; INTERSPECIES TRANSMISSION; COMMERCIAL POULTRY;
BRITISH-COLUMBIA; DOMESTIC POULTRY; INNATE IMMUNITY; WILD BIRDS
AB Subtype H7 avian-origin influenza A viruses (AIVs) have caused at least 500 confirmed human infections since 2003 and culling of >75 million birds in recent years. Here we antigenically and genetically characterized 93 AIV isolates from North America (85 from migratory waterfowl [1976-2010], 7 from domestic poultry [1971-2012], and 1 from a seal [1980]). The hemagglutinin gene of these H7 viruses are separated from those from Eurasia. Gradual accumulation of nucleotide and amino acid substitutions was observed in the hemagglutinin of H7 AIVs from waterfowl and domestic poultry. Genotype characterization suggested that H7 AIVs in wild birds form diverse and transient internal gene constellations. Serologic analyses showed that the 93 isolates cross-reacted with each other to different extents. Antigenic cartography showed that the average antigenic distance among them was 1.14 units (standard deviation [SD], 0.57 unit) and that antigenic diversity among the H7 isolates we tested was limited. Our results suggest that the continuous genetic evolution has not led to significant antigenic diversity for H7 AIVs from North America. These findings add to our understanding of the natural history of IAVs and will inform public health decision-making regarding the threat these viruses pose to humans and poultry.
C1 [Xu, Yifei; Bailey, Elizabeth; Wang, Hui; Long, Li-Ping; Wan, Xiu-Feng] Mississippi State Univ, Coll Vet Med, Dept Basic Sci, Mississippi State, MS 39762 USA.
[Spackman, Erica] ARS, Exot & Emerging Avian Viral Dis Unit, Southeast Poultry Res Lab, US Natl Poultry Res Ctr,USDA, Athens, GA USA.
[Li, Tao; Lin, Xiaoxu; Jarman, Richard G.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD USA.
[Baroch, John A.; DeLiberto, Thomas J.] USDA, Natl Wildlife Res Ctr, Wildlife Serv, Anim & Plant Hlth Inspect Serv, Ft Collins, CO USA.
[Cunningham, Fred L.] USDA, Mississippi Field Stn, Natl Wildlife Res Ctr, Wildlife Serv,Anim & Plant Hlth Inspect Serv, Mississippi State, MS USA.
RP Wan, XF (reprint author), Mississippi State Univ, Coll Vet Med, Dept Basic Sci, Mississippi State, MS 39762 USA.
EM wan@cvm.msstate.edu
FU NIH/NIAID [R01 AI116744]; Department of Defense (DoD) Global Emerging
Infections Surveillance and Response System (GEIS), a Division of the
Armed Forces Health Surveillance Center [P0172]
FX We thank Nan Zhao and Lucy Senter for technical assistance with this
project. This project was supported partially by NIH/NIAID grant no. R01
AI116744 to XFW and by funding from the Department of Defense (DoD)
Global Emerging Infections Surveillance and Response System (GEIS), a
Division of the Armed Forces Health Surveillance Center grant no. P0172
to RGJ and XL.
NR 70
TC 1
Z9 1
U1 1
U2 11
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD FEB 9
PY 2016
VL 6
AR 20688
DI 10.1038/srep20688
PG 17
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DD0MT
UT WOS:000369614800001
PM 26858078
ER
PT J
AU Das, S
Dubey, M
Roelofs, A
AF Das, Saptarshi
Dubey, Madan
Roelofs, Andreas
TI High gain, low noise, fully complementary logic inverter based on
bi-layer WSe2 field effect transistors (vol 105, 083511, 2014)
SO APPLIED PHYSICS LETTERS
LA English
DT Correction
C1 [Das, Saptarshi; Roelofs, Andreas] Argonne Natl Lab, Ctr Nanoscale Mat, Argonne, IL 60439 USA.
[Dubey, Madan] US Army, Res Lab, Adelphi, MD 20783 USA.
RP Das, S (reprint author), Argonne Natl Lab, Ctr Nanoscale Mat, Argonne, IL 60439 USA.
NR 1
TC 0
Z9 0
U1 6
U2 9
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0003-6951
EI 1077-3118
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD FEB 8
PY 2016
VL 108
IS 6
AR 069902
DI 10.1063/1.4941819
PG 1
WC Physics, Applied
SC Physics
GA DH8PJ
UT WOS:000373056300061
ER
PT J
AU Derrick, TR
Edwards, WB
Fellin, RE
Seay, JF
AF Derrick, Timothy R.
Edwards, W. Brent
Fellin, Rebecca E.
Seay, Joseph F.
TI An integrative modeling approach for the efficient estimation of cross
sectional tibial stresses during locomotion
SO JOURNAL OF BIOMECHANICS
LA English
DT Article
DE Finite element method; Internal bone moments; Bone models; Beam theory;
Strain gage
ID INHOMOGENEOUS MATERIAL PROPERTIES; SHEAR STRESSES; BONE; FRACTURES;
TRANSVERSE; DENSITY; LOADS
AB The purpose of this research was to utilize a series of models to estimate the stress in a cross section of the tibia, located 62% from the proximal end, during walking. Twenty-eight male, active duty soldiers walked on an instrumented treadmill while external force data and kinematics were recorded. A rigid body model was used to estimate joint moments and reaction forces. A musculoskeletal model was used to gather muscle length, muscle velocity, moment arm and orientation information. Optimization procedures were used to estimate muscle forces and finally internal bone forces and moments were applied to an inhomogeneous, subject specific bone model obtained from CT scans to estimate stress in the bone cross section. Validity was assessed by comparison to stresses calculated from strain gage data in the literature and sensitivity was investigated using two simplified versions of the bone model-a homogeneous model and an ellipse approximation. Peak compressive stress occurred on the posterior aspect of the cross section ( -47.5 +/- 14.9 MPa). Peak tensile stress occurred on the anterior aspect (27.0 +/- 11.7 MPa) while the location of peak shear was variable between subjects (7.2 +/- 2.4 MPa). Peak compressive, tensile and shear stresses were within 0.52 MPa, 0.36 MPa and 3.02 MPa respectively of those calculated from the converted strain gage data. Peak values from a inhomogeneous model of the bone correlated well with homogeneous model (normal: 0.99; shear: 0.94) as did the normal ellipse model (r=0.89-0.96). However, the relationship between shear stress in the inhomogeneous model and ellipse model was less accurate (r=0.64). The procedures detailed in this paper provide a non-invasive and relatively quick method of estimating cross sectional stress that holds promise for assessing injury and osteogenic stimulus in bone during normal physical activity. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Derrick, Timothy R.] Iowa State Univ, Dept Kinesiol, Ames, IA 50011 USA.
[Edwards, W. Brent] Univ Calgary, Fac Kinesiol, Calgary, AB, Canada.
[Fellin, Rebecca E.; Seay, Joseph F.] US Army, Environm Med Res Inst, Natick, MA 01760 USA.
RP Derrick, TR (reprint author), Iowa State Univ, 249 Forker Bldg, Ames, IA 50011 USA.
EM tderrick@iastate.edu
NR 24
TC 1
Z9 1
U1 2
U2 2
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0021-9290
EI 1873-2380
J9 J BIOMECH
JI J. Biomech.
PD FEB 8
PY 2016
VL 49
IS 3
BP 429
EP 435
DI 10.1016/j.jblomech.2016.01.003
PG 7
WC Biophysics; Engineering, Biomedical
SC Biophysics; Engineering
GA DF7PA
UT WOS:000371548700017
PM 26803338
ER
PT J
AU Binder, R
Roberts, AT
Kwong, NH
Sandhu, A
Everitt, HO
AF Binder, Rolf
Roberts, Adam T.
Kwong, Nai H.
Sandhu, Arvinder
Everitt, Henry O.
TI Global k-space analysis of electron-phonon interaction in graphene and
application to M-point spectroscopy
SO PHYSICAL REVIEW B
LA English
DT Article
ID FANO-RESONANT METASURFACES; FEW-LAYER GRAPHENE; RAMAN-SPECTROSCOPY;
BILAYER GRAPHENE; GRAPHITE; DYNAMICS; LIGHT
AB Recently, optical probes have become available that can access and observe energy renormalization due to electron-phonon interaction in graphene away from the well-studied Dirac K point. Using an expanded deformation potential approach, we present a theoretical study of the electron-phonon self-energy and scattering matrix elements across the entire Brillouin zone. We elucidate the roles of modulated hopping and conventional deformation potential coupling, parameterized via standard deformation potentials, the in-plane phonon modes, intra- and interband contributions, and umklapp processes. Applying the theory to nonlinear optical transmission spectroscopy in the vicinity of the M point, we find very good agreement with recently published experimental data.
C1 [Binder, Rolf; Roberts, Adam T.; Kwong, Nai H.; Sandhu, Arvinder] Univ Arizona, Coll Opt Sci, Tucson, AZ 85721 USA.
[Binder, Rolf; Sandhu, Arvinder] Univ Arizona, Dept Phys, Tucson, AZ 85721 USA.
[Roberts, Adam T.; Everitt, Henry O.] US Army Aviat & Missile Res, Ctr Dev & Engn, Redstone Arsenal, AL 35898 USA.
[Everitt, Henry O.] Duke Univ, Dept Phys, Durham, NC 27708 USA.
RP Binder, R (reprint author), Univ Arizona, Coll Opt Sci, Tucson, AZ 85721 USA.; Binder, R (reprint author), Univ Arizona, Dept Phys, Tucson, AZ 85721 USA.
NR 100
TC 0
Z9 0
U1 12
U2 18
PU AMER PHYSICAL SOC
PI COLLEGE PK
PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA
SN 2469-9950
EI 2469-9969
J9 PHYS REV B
JI Phys. Rev. B
PD FEB 8
PY 2016
VL 93
IS 8
AR 085414
DI 10.1103/PhysRevB.93.085414
PG 18
WC Physics, Condensed Matter
SC Physics
GA DD2BW
UT WOS:000369728400007
ER
PT J
AU Wang, GX
Loh, GC
Pandey, R
Karna, SP
AF Wang, Gaoxue
Loh, G. C.
Pandey, Ravindra
Karna, Shashi P.
TI Out-of-plane structural flexibility of phosphorene
SO NANOTECHNOLOGY
LA English
DT Article
DE phosphorene; buckling; structural flexibility; molecular dynamics;
density functional theory
ID FIELD-EFFECT TRANSISTORS; LAYER BLACK PHOSPHORUS; MONOLAYER GRAPHENE;
MOLECULAR-DYNAMICS; HIGH-QUALITY; MEMBRANES; STRAIN
AB Phosphorene has been rediscovered recently, establishing itself as one of the most promising two-dimensional group-V elemental monolayers with direct band gap, high carrier mobility, and anisotropic electronic properties. In this paper, surface buckling and its effect on its electronic properties are investigated by using molecular dynamics simulations together with density functional theory calculations. We find that phosphorene shows superior structural flexibility along the armchair direction allowing it to have large curvatures. The semiconducting and direct band gap nature are retained with buckling along the armchair direction; the band gap decreases and transforms to an indirect band gap with buckling along the zigzag direction. The structural flexibility and electronic robustness along the armchair direction facilitate the fabrication of devices with complex shapes, such as folded phosphorene and phosphorene nano-scrolls, thereby offering new possibilities for the application of phosphorene in flexible electronics and optoelectronics.
C1 [Wang, Gaoxue; Pandey, Ravindra] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA.
[Loh, G. C.] Inst High Performance Comp, 1 Fusionopolis Way,16-16 Connexis, Singapore 138632, Singapore.
[Karna, Shashi P.] US Army Res Lab, Weap & Mat Res Directorate, ATTN RDRL WM, Aberdeen Proving Ground, MD 21005 USA.
RP Wang, GX; Pandey, R (reprint author), Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA.; Karna, SP (reprint author), US Army Res Lab, Weap & Mat Res Directorate, ATTN RDRL WM, Aberdeen Proving Ground, MD 21005 USA.
EM gaoxuew@mtu.edu; pandey@mtu.edu; shashi.p.karna.civ@mail.mil
RI Wang, Gaoxue/C-9492-2017
OI Wang, Gaoxue/0000-0003-2539-3405
FU Army Research Office [W911NF-14-2-0088]
FX RAMA and Superior, high performance computing clusters at Michigan
Technological University, were used in obtaining results presented in
this paper. Supports from Dr S Gowtham are acknowledged. Partial
research support for this work from the Army Research Office, Contract #
W911NF-14-2-0088 is gratefully acknowledged.
NR 43
TC 13
Z9 13
U1 8
U2 62
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0957-4484
EI 1361-6528
J9 NANOTECHNOLOGY
JI Nanotechnology
PD FEB 5
PY 2016
VL 27
IS 5
AR 055701
DI 10.1088/0957-4484/27/5/055701
PG 7
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary;
Physics, Applied
SC Science & Technology - Other Topics; Materials Science; Physics
GA DC0GD
UT WOS:000368894300015
ER
PT J
AU Luo, C
Zhu, YJ
Borodin, O
Gao, T
Fan, XL
Xu, YH
Xu, K
Wang, CS
AF Luo, Chao
Zhu, Yujie
Borodin, Oleg
Gao, Tao
Fan, Xiulin
Xu, Yunhua
Xu, Kang
Wang, Chunsheng
TI Activation of Oxygen-Stabilized Sulfur for Li and Na Batteries
SO ADVANCED FUNCTIONAL MATERIALS
LA English
DT Article
DE composites; electrochemical activation; lithium sulfur batteries; oxygen
stabilized carbon; sulfur; oxygen-sulfur bonds; sodium sulfur batteries
ID LITHIUM-ION BATTERIES; CATHODE MATERIAL; CYCLING STABILITY; CARBON
NANOTUBES; S BATTERIES; PERFORMANCE; CELLS; COMPOSITE; GRAPHENE; ANODES
AB The sulfur-based cathode materials suffer severely from poor cycling stability and low utilization, incurred by their stepwise reaction mechanism that generates polysulfide intermediates and the subsequent irreversible losses. In this work, those issues are significantly relieved by entrapping sulfur species in carbon host rich in oxygen functionalities. Sulfur species in such C/S composite are highly stabilized by their interaction with oxygen, and can deliver a reversible capacity of 508 mAh/(g of S) for 2000 cycles when coupled with Li, representing the best cycling stability up to date. More interestingly, extra capacity can be accessed by simply prelithiating the oxygen-stabilized C/S composites down to 0.6 V for a few cycles, which enables a high capacity of 1621 mAh/(g of S) that eventually stabilizes at 820 mAh/(g of S) for 600 cycles. The mechanism for this electrochemical activation process is investigated with both spectroscopic and electrochemical techniques, which reveal that the inactive sulfur bonded to oxygen is liberated in the initial deep lithiation precycles and becomes electrochemically active. The oxygen-stabilized sulfur can also be coupled with Na anode to form Na/S cell, confirming that the formation of S-O interaction in C/S composite generates promising sulfur-based cathode materials for Li-S and Na-S batteries.
C1 [Luo, Chao; Zhu, Yujie; Gao, Tao; Fan, Xiulin; Xu, Yunhua; Wang, Chunsheng] Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA.
[Borodin, Oleg; Xu, Kang] US Army, Res Lab, Electrochem Branch, Adelphi, MD 20783 USA.
RP Wang, CS (reprint author), Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA.; Xu, K (reprint author), US Army, Res Lab, Electrochem Branch, Adelphi, MD 20783 USA.
EM conrad.k.xu.civ@mail.mil; cswang@umd.edu
RI Wang, Chunsheng/H-5767-2011
OI Wang, Chunsheng/0000-0002-8626-6381
FU Army Research Office [W911NF10200]; Maryland Nano Center; NispLab; NSF
as a MRSEC Shared Experimental Facility
FX This work was supported by the Army Research Office under Contract No.
W911NF10200. The authors acknowledge the support of the Maryland Nano
Center and its NispLab. The NispLab is supported in part by the NSF as a
MRSEC Shared Experimental Facility. The authors acknowledge Dr. Cynthia
Lundgren and Dr. Karen Gaskell for the technique support.
NR 36
TC 13
Z9 13
U1 40
U2 135
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 1616-301X
EI 1616-3028
J9 ADV FUNCT MATER
JI Adv. Funct. Mater.
PD FEB 2
PY 2016
VL 26
IS 5
BP 745
EP 752
DI 10.1002/adfm.201503918
PG 8
WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied;
Physics, Condensed Matter
SC Chemistry; Science & Technology - Other Topics; Materials Science;
Physics
GA DD5MX
UT WOS:000369969100011
ER
PT J
AU Pelin, M
Forino, M
Brovedani, V
Tartaglione, L
Dell'Aversano, C
Pistocchi, R
Poli, M
Sosa, S
Florio, C
Ciminiello, P
Tubaro, A
AF Pelin, Marco
Forino, Martino
Brovedani, Valentina
Tartaglione, Luciana
Dell'Aversano, Carmela
Pistocchi, Rossella
Poli, Mark
Sosa, Silvio
Florio, Chiara
Ciminiello, Patrizia
Tubaro, Aurelia
TI Ovatoxin-a, A Palytoxin Analogue Isolated from Ostreopsis cf. ovata
Fukuyo: Cytotoxic Activity and ELISA Detection
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID RESOLUTION MASS-SPECTROMETRY; FRENCH MEDITERRANEAN COAST; PUTATIVE
PALYTOXIN; STRUCTURE ELUCIDATION; TOXIN PROFILE; MARINE TOXIN; HACAT
CELLS; OSTREOCIN-D; SEA; ACCUMULATION
AB This study provides the first evaluation of the cytotoxic effects of the recently identified palytoxin (PLTX) analog, ovatoxin-a (OVTX-a), the major toxin produced by Ostreopsis cf. ovata in the Mediterranean Sea. Its increasing detection during Ostreopsis blooms and in seafood highlights the need to characterize its toxic effects and to set up appropriate detection methods. OVTX-a is about 100 fold less potent than PLTX in reducing HaCaT cells viability (EC50 = 1.1 X 10(-9) M vs 1.8 X 10(-11) M, MTT test) in agreement with a reduced binding affinity (Kd = 1.2 X 10(-9) vs 2.7 X 10(-11) M, saturation experiments on intact cells). Similarly, OVTX-a hemolytic effect is lower than that of the reference PLTX compound. OstD shows the lowest cytotoxicity toward HaCaT keratinocytes, suggesting the lack of a hydroxyl group at C44 as a critical feature for PLTXs cytotoxic effects. A sandwich ELISA developed for PLTX detects also OVTX-a in a sensitive (LOD = 4.2 and LOQ = 5.6 ng/mL) and accurate manner (Bias = 0.3%), also in 0. cf. ovata extracts and contaminated mussels. Although in vitro OVTXa appears less toxic than PLTX, its cytotoxicity at nanomolar concentrations after short exposure time rises some concern for human health. The sandwich ELISA can be a viable screening method for OVTXs detection in monitoring program.
C1 [Pelin, Marco; Brovedani, Valentina; Sosa, Silvio; Florio, Chiara; Tubaro, Aurelia] Univ Trieste, Dept Life Sci, Via A Valerio 6, I-34127 Trieste, Italy.
[Forino, Martino; Tartaglione, Luciana; Dell'Aversano, Carmela; Ciminiello, Patrizia] Univ Naples Federico II, Dept Pharm, I-80131 Naples, Italy.
[Pistocchi, Rossella] Univ Bologna, Interdept Ctr Res Environm Sci, I-481230 Ravenna, Italy.
[Poli, Mark] US Army Med Res, Inst Infect Dis, Ft Detrick, MD 21701 USA.
RP Tubaro, A (reprint author), Univ Trieste, Dept Life Sci, Via A Valerio 6, I-34127 Trieste, Italy.
EM tubaro@units.it
FU University of Trieste (Universita degli Studi di Trieste - Finanziamento
di Ateneo per progetti di ricerca scientifica - FRA); University of
Naples; Compagnia di San Paolo
FX This work was supported by a grant of the University of Trieste
(Universita degli Studi di Trieste - Finanziamento di Ateneo per
progetti di ricerca scientifica - FRA 2012). Chemical analyses were
carried out in the framework of Programme STAR Linea 1 2013 (VALTOX,
Napoli_cal12013_08) financially supported by University of Naples and
Compagnia di San Paolo. The authors are grateful to Prof. Takeshi
Yasumoto (Japan Food Research Laboratories) for kindly supply
ostreocin-D.
NR 40
TC 4
Z9 5
U1 6
U2 20
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD FEB 2
PY 2016
VL 50
IS 3
BP 1544
EP 1551
DI 10.1021/acs.est.5b04749
PG 8
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA DC8LO
UT WOS:000369471300054
PM 26714047
ER
PT J
AU Krakauer, T
Pradhan, K
Stiles, BG
AF Krakauer, Teresa
Pradhan, Kisha
Stiles, Bradley G.
TI Staphylococcal Superantigens Spark Host-Mediated Danger Signals
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Review
DE SEB; superantigens; toxic shock; damage response; therapy; animal models
ID TOXIC-SHOCK-SYNDROME; CLASS-II MOLECULES; COMPLEX CLASS-II;
TUMOR-NECROSIS-FACTOR; INNATE IMMUNE-RESPONSE; T-CELL-ACTIVATION;
CYTOKINE GENE-EXPRESSION; BLOOD MONONUCLEAR-CELLS; INDUCED LETHAL SHOCK;
AUREUS CA-MRSA
AB Staphylococcal enterotoxin B (SEB) of Staphylococcus aureus, and related superantigenic toxins produced by myriad microbes, are potent stimulators of the immune system causing a variety of human diseases from transient food poisoning to lethal toxic shock. These protein toxins bind directly to specific V beta regions of T-cell receptors (TCR) and major histocompatibility complex (MHC) class II on antigen-presenting cells, resulting in hyperactivation of T lymphocytes and monocytes/macrophages. Activated host cells produce excessive amounts of proinflammatory cytokines and chemokines, especially tumor necrosis factor alpha, interleukin 1 (IL-1), IL-2, interferon gamma (IFN gamma), and macrophage chemoattractant protein 1 causing clinical symptoms of fever, hypotension, and shock. Because of superantigen-induced T cells skewed toward TH1 helper cells, and the induction of proinflammatory cytokines, superantigens can exacerbate autoimmune diseases. Upon TCR/MHC ligation, pathways induced by superantigens include the mitogen-activated protein kinase cascades and cytokine receptor signaling, resulting in activation of NF kappa B and the phosphoinositide 3-kinase/mammalian target of rapamycin pathways. Various mouse models exist to study SEB-induced shock including those with potentiating agents, transgenic mice and an "SEB-only" model. However, therapeutics to treat toxic shock remain elusive as host response genes central to pathogenesis of superantigens have only been identified recently. Gene profiling of a murine model for SEB-induced shock reveals novel molecules upregulated in multiple organs not previously associated with SEB-induced responses. The pivotal genes include intracellular DNA/RNA sensors, apoptosis/DNA damage-related molecules, immunoproteasome components, as well as antiviral and IFN-stimulated genes. The host-wide induction of these, and other, antimicrobial defense genes provide evidence that SEB elicits danger signals resulting in multi-organ damage and toxic shock. Ultimately, these discoveries might lead to novel therapeutics for various superantigen-based diseases.
C1 [Krakauer, Teresa] US Army Med Res Inst Infect Dis, Dept Immunol, Mol Translat Sci Div, Frederick, MD USA.
[Pradhan, Kisha; Stiles, Bradley G.] Wilson Coll, Dept Biol, Chambersburg, PA USA.
RP Krakauer, T (reprint author), US Army Med Res Inst Infect Dis, Dept Immunol, Mol Translat Sci Div, Frederick, MD USA.; Stiles, BG (reprint author), Wilson Coll, Dept Biol, Chambersburg, PA USA.
EM teresa.krakauer.civ@mail.mil; brad.stiles@wilson.edu
FU DTRA
FX We thank DTRA for funding. Brad Stiles acknowledges Wilson College for
the continuing support of this, and many other, endeavors.
NR 182
TC 1
Z9 1
U1 4
U2 22
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015,
SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD FEB 2
PY 2016
VL 7
AR 23
DI 10.3389/fimmu.2016.00023
PG 14
WC Immunology
SC Immunology
GA DC3HW
UT WOS:000369111400003
PM 26870039
ER
PT J
AU Katlein, C
Perovich, DK
Nicolaus, M
AF Katlein, Christian
Perovich, Donald K.
Nicolaus, Marcel
TI Geometric Effects of an Inhomogeneous Sea Ice Cover on the under Ice
Light Field
SO Frontiers in Earth Science
LA English
DT Article
DE optics; irradiance; inherent optical properties; spatial variability;
extinction coefficient
ID TRANSMISSION; OCEAN; MELT
AB Light measurements in the ocean provide crucial information about the energy fluxes in the climate and ecosystem. Currently radiative transfer problems are usually considered in horizontally homogeneous layers although it is known to be a crude assumption in many cases. In this paper, we examine the effects of a horizontally inhomogeneous sea ice layer on the light field in the water underneath. We implemented a three dimensional model, capable to simulate the light field underneath arbitrary surface geometries using ray optics. The results show clear effects of the measurement geometry on measured fluxes obtained with different sensor types, which need to be taken into account for the correct interpretation of the data. Radiance sensors are able to better sense the spatial variability of ice optical properties as compared to irradiance sensors. Furthermore, we show that the determination of the light extinction coefficient of water from vertical profiles is complicated under a horizontally inhomogeneous ice cover. This uncertainty in optical properties of the water, as well as the measurement geometry also limits the possibility to correct light measurements taken at depth for the influence of water in between the sea ice and the sensor.
C1 [Katlein, Christian; Nicolaus, Marcel] Helmholtz Zentrum Polar & Meeresforsch, Alfred Wegener Inst, Sea Ice Phys, Bremerhaven, Germany.
[Perovich, Donald K.] Cold Reg Res & Engn Lab, Hanover, NH USA.
RP Katlein, C (reprint author), Helmholtz Zentrum Polar & Meeresforsch, Alfred Wegener Inst, Sea Ice Phys, Bremerhaven, Germany.
EM christian.katlein@awi.de
OI Katlein, Christian/0000-0003-2422-0414
FU graduate school POLMAR; Office of Naval Research;
Alfred-Wegener-Institut Helmholtz-Zentrum fur Polar- und Meeresforschung
FX CK thanks the graduate school POLMAR for granting an outgoing
scholarship to visit DP which supported the writing of this manuscript.
DP thanks the Office of Naval Research for their support. We thank R.
Gerdes and two anonymous reviewers of an earlier version for comments on
the manuscript. This study was funded by the Alfred-Wegener-Institut
Helmholtz-Zentrum fur Polar- und Meeresforschung. The MATLAB code of the
model used in this study is available at
http://www.mathworks.com/matlabcentral/fileexchange/50566-geometric-ligh
t-field-model.
NR 26
TC 1
Z9 1
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015,
SWITZERLAND
SN 2296-6463
J9 FRONT EARTH SCI
JI Front. Earth Sci.
PD FEB 2
PY 2016
VL 4
AR UNSP 6
DI 10.3389/feart.2016.00006
PG 10
WC Geosciences, Multidisciplinary
SC Geology
GA EJ2SW
UT WOS:000393062400001
ER
PT J
AU Moser, RD
Kurtis, KE
Singh, PM
Kahn, LF
AF Moser, Robert D.
Kurtis, Kimberly E.
Singh, Preet M.
Kahn, Lawrence F.
TI Effect of sulfates on passivation in alkaline environments
SO PROCEEDINGS OF THE INSTITUTION OF CIVIL ENGINEERS-CONSTRUCTION MATERIALS
LA English
DT Article
DE concrete technology & manufacture; corrosion; materials technology
ID SIMULATED PORE SOLUTIONS; STAINLESS-STEELS; CORROSION-RESISTANCE;
BEHAVIOR
AB Studies investigating passivation behaviour and corrosion resistance in simulated alkaline environments have typically been conducted in solutions containing sodium hydroxide (NaOH), potassium hydroxide (KOH) and calcium hydroxide (Ca(OH)(2)), with limited study of the effect of sulfates (SO42-). These sulfates are known to be present in the pore solution of materials like Portland cement-based concrete and may also ingress by the exposure to sulfate-rich environments. This study investigates the passivation behaviour and potentiodynamic polarisation behaviour of a high-strength carbon steel and high-strength stainless steels (austenitic and duplex) in saturated calcium hydroxide solutions containing up to 2000 ppm SO42-. Results indicate a negligible impact on the passivation behaviours of single-phase carbon steel and austenitic stainless steels. However, in duplex stainless steels, 1000 ppm of SO42- promotes passivation, whereas higher concentrations of 2000 ppm inhibit passivation. Additional research is necessary to correlate the altered passivation behaviour resulting from the presence of SO42- with chloride-induced corrosion resistance.
C1 [Moser, Robert D.] US Army Engineer Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA.
[Kurtis, Kimberly E.; Kahn, Lawrence F.] Georgia Inst Technol, Sch Civil & Environm Engn, Atlanta, GA 30332 USA.
[Singh, Preet M.] Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA.
RP Moser, RD (reprint author), US Army Engineer Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA.
NR 17
TC 1
Z9 1
U1 1
U2 1
PU ICE PUBLISHING
PI WESTMINISTER
PA INST CIVIL ENGINEERS, 1 GREAT GEORGE ST, WESTMINISTER SW 1P 3AA, ENGLAND
SN 1747-650X
EI 1747-6518
J9 PROC INST CIV ENG-CO
JI Proc. Inst. Civ. Eng.-Constr. Mater.
PD FEB
PY 2016
VL 169
IS 1
BP 39
EP 43
DI 10.1680/coma.14.00016
PG 5
WC Construction & Building Technology
SC Construction & Building Technology
GA DZ8GJ
UT WOS:000386108600005
ER
PT J
AU Carter, R
Hinojosa-Laborde, C
Convertino, VA
AF Carter, Robert, III
Hinojosa-Laborde, Carmen
Convertino, Victor A.
TI Variability in integration of mechanisms associated with high tolerance
to progressive reductions in central blood volume: the compensatory
reserve
SO PHYSIOLOGICAL REPORTS
LA English
DT Article
DE Presyncope; hypovolemia; hemorrhage; compensatory reserve
ID BODY NEGATIVE-PRESSURE; HEART-RATE-VARIABILITY; CENTRAL HYPOVOLEMIA;
ARTERIAL-PRESSURE; BAROREFLEX; TRAUMA; EPIDEMIOLOGY; OSCILLATIONS;
SENSITIVITY; INFARCTION
AB High tolerance to progressive reductions in central blood volume has been associated with higher heart rate (HR), peripheral vascular resistance (PVR), sympathetic nerve activity (SNA), and vagally mediated cardiac baroreflex sensitivity (BRS). Using a database of 116 subjects classified as high tolerance to presyncopal-limited lower body negative pressure (LBNP), we tested the hypothesis that subjects with greater cardiac baroreflex withdrawal (i.e., BRS > 1.0) would demonstrate greater LBNP tolerance associated with higher HR, PVR, and SNA. Subjects underwent LBNP to presyncope. Mean and diastolic arterial pressure (MAP; DAP) was measured by finger photoplethysmography and BRS (down sequence) was autocalculated (WinCPRS) as Delta R-R Interval/Delta DAP. Down(BRS) (ms/mmHg) was used to dichotomize subjects into two groups (Group 1 = Down(BRS) > 1.0, N = 49, and Group 2 = Down(BRS) < 1.0, N = 67) at the time of presyncope. Muscle SNA was measured directly from the peroneal nerve via microneurography (N = 19) in subjects from Groups 1 (n = 9) and 2 (n = 10). Group 1 (Down(BRS) > 1.0) had lower HR (107 +/- 19 vs. 131 +/- 20 bpm), higher stroke volume (45 +/- 15 vs. 36 +/- 15 mL), less SNA (45 +/- 13 vs. 53 +/- 7 bursts/min), and less increase in PVR (4.1 +/- 1.3 vs. 4.5 +/- 2.6) compared to Group 2 (Down(BRS) < 1.0). Both groups had similar tolerance times (1849 +/- 260 vs. 1839 +/- 253 sec), MAP (78 +/- 11 vs. 79 +/- 12 mmHg), compensatory reserve index (CRI) (0.10 +/- 0.03 vs. 0.09 +/- 0.01), and cardiac output (4.5 +/- 1.2 vs. 4.7 +/- 1.1 L/min) at presyncope. Contrary to our hypothesis, higher HR, PVR, SNA, and BRS were not associated with greater tolerance to reduced central blood volume. These data are the first to demonstrate the variability and uniqueness of individual human physiological strategies designed to compensate for progressive reductions in central blood volume. The sum total of these integrated strategies is accurately reflected by the measurement of the compensatory reserve.
C1 [Carter, Robert, III; Hinojosa-Laborde, Carmen; Convertino, Victor A.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
RP Carter, R (reprint author), US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
EM robert.carter422.mil@mail.mil
NR 27
TC 2
Z9 2
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2051-817X
J9 PHYSIOL REP
JI PHYSIOL. REP.
PD FEB
PY 2016
VL 4
IS 4
AR e12705
DI 10.14814/phy2.12705
PG 7
WC Physiology
SC Physiology
GA DR9SU
UT WOS:000380237200004
ER
PT J
AU Cooper, SA
Desjardins, PJ
Turk, DC
Dworkin, RH
Katz, NP
Kehlet, H
Ballantyne, JC
Burke, LB
Carragee, E
Cowan, P
Croll, S
Dionne, RA
Farrar, JT
Gilron, I
Gordon, DB
Iyengar, S
Jay, GW
Kalso, EA
Kerns, RD
McDermott, MP
Raja, SN
Rappaport, BA
Rauschkolb, C
Royal, MA
Segerdahl, M
Stauffer, JW
Todd, KH
Vanhove, GF
Wallace, MS
West, C
White, RE
Wu, C
AF Cooper, Stephen A.
Desjardins, Paul J.
Turk, Dennis C.
Dworkin, Robert H.
Katz, Nathaniel P.
Kehlet, Henrik
Ballantyne, Jane C.
Burke, Laurie B.
Carragee, Eugene
Cowan, Penney
Croll, Scott
Dionne, Raymond A.
Farrar, John T.
Gilron, Ian
Gordon, Debra B.
Iyengar, Smriti
Jay, Gary W.
Kalso, Eija A.
Kerns, Robert D.
McDermott, Michael P.
Raja, Srinivasa N.
Rappaport, Bob A.
Rauschkolb, Christine
Royal, Mike A.
Segerdahl, Marta
Stauffer, Joseph W.
Todd, Knox H.
Vanhove, Geertrui F.
Wallace, Mark S.
West, Christine
White, Richard E.
Wu, Christopher
TI Research design considerations for single-dose analgesic clinical trials
in acute pain: IMMPACT recommendations
SO PAIN
LA English
DT Review
DE Randomized clinical trials; Acute pain; Research design; Assay
sensitivity; Proof-of-concept trials; Clinical trial methods
ID POSTOPERATIVE DENTAL PAIN; INDIVIDUAL PATIENT METAANALYSIS;
PLACEBO-CONTROLLED TRIALS; ACTIVE-CONTROL TRIALS; MOVEMENT-EVOKED PAIN;
DOUBLE-BLIND; RATING-SCALES; PARECOXIB SODIUM; MISSING DATA; EFFICACY
AB This article summarizes the results of a meeting convened by the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) on key considerations and best practices governing the design of acute pain clinical trials. We discuss the role of early phase clinical trials, including pharmacokinetic-pharmacodynamic (PK-PD) trials, and the value of including both placebo and active standards of comparison in acute pain trials. This article focuses on single-dose and short-duration trials with emphasis on the perioperative and study design factors that influence assay sensitivity. Recommendations are presented on assessment measures, study designs, and operational factors. Although most of the methodological advances have come from studies of postoperative pain after dental impaction, bunionectomy, and other surgeries, the design considerations discussed are applicable to many other acute pain studies conducted in different settings.
C1 [Cooper, Stephen A.] Stephen A Cooper LLC, Palm Beach Gardens, FL USA.
[Desjardins, Paul J.] Tufts Univ, Desjardins Associates LLC, Boston, MA 02111 USA.
[Desjardins, Paul J.] Tufts Univ, Dept Oral & Maxillofacial Surg, Boston, MA 02111 USA.
[Turk, Dennis C.; Ballantyne, Jane C.] Univ Washington, Dept Anesthesiol & Pain Med, Seattle, WA 98195 USA.
[Dworkin, Robert H.; McDermott, Michael P.] Univ Rochester, Dept Anesthesiol, Rochester, NY USA.
[Dworkin, Robert H.; McDermott, Michael P.] Univ Rochester, Dept Neurol, Rochester, NY USA.
[Dworkin, Robert H.; McDermott, Michael P.] Univ Rochester, Dept Biostat & Computat Biol, Rochester, NY USA.
[Katz, Nathaniel P.] Analges Solut, Needham, MA USA.
[Kehlet, Henrik] Rigshosp, Sect Surg Pathophysiol, Copenhagen, Denmark.
[Burke, Laurie B.] Univ Maryland, Dept Hlth Serv Res, Baltimore, MD 21201 USA.
[Burke, Laurie B.] LORA Grp LLC, Royal Oak, MD USA.
[Carragee, Eugene] Stanford Univ, Dept Orthoped Surg, Palo Alto, CA 94304 USA.
[Cowan, Penney] Amer Chron Pain Assoc, Rocklin, CA USA.
[Croll, Scott] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
[Dionne, Raymond A.] E Carolina Univ, Dept Pharmacol, Greenville, NC USA.
[Dionne, Raymond A.] E Carolina Univ, Dept Toxicol, Greenville, NC USA.
[Dionne, Raymond A.] E Carolina Univ, Dept Foundat Sci, Greenville, NC USA.
[Farrar, John T.] Univ Penn, Dept Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA.
[Gilron, Ian] Queens Univ, Dept Anesthesiol, Kingston, ON, Canada.
[Gordon, Debra B.] Univ Washington, Dept Anesthesiol & Pain Med, Seattle, WA USA.
[Iyengar, Smriti] Eli Lilly & Co, Indianapolis, IN 46285 USA.
[Jay, Gary W.] Advise Clin, Raleigh, NC USA.
[Kalso, Eija A.] Univ Helsinki, Dept Anaesthesia Intens Care & Pain Med, Helsinki, Finland.
[Kalso, Eija A.] Helsinki Univ Hosp, Helsinki, Finland.
[Kerns, Robert D.] US Dept Vet Affairs, New Haven, CT USA.
[Raja, Srinivasa N.; Wu, Christopher] Johns Hopkins Univ, Dept Anesthesiol & Crit Care Med, Baltimore, MD USA.
[Rappaport, Bob A.] Analges Concepts LLC, Arlington, VA USA.
[Rauschkolb, Christine] Johnson & Johnson Pharmaceut Res & Dev, Titusville, NY USA.
[Royal, Mike A.] Sorrento Therapeut, San Diego, CA USA.
[Segerdahl, Marta] Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.
[Stauffer, Joseph W.] Johns Hopkins Univ, Baltimore, MD USA.
[Stauffer, Joseph W.] Cara Therapeut, Shelton, CT USA.
[Todd, Knox H.] Univ Texas MD Anderson Canc Ctr, Dept Emergency Med, Houston, TX 77030 USA.
[Vanhove, Geertrui F.] NeurogesX, San Carlos, CA USA.
[Wallace, Mark S.] Univ Calif San Diego, Dept Anesthesiol, San Diego, CA 92103 USA.
[West, Christine] Pfizer Inc, Groton, CT 06340 USA.
[White, Richard E.] Endo Pharmaceut, Chadds Ford, PA USA.
RP Cooper, SA (reprint author), 40 Durand Rd, Maplewood, NJ 07040 USA.
EM paul.j.desjardins@gmail.com
FU Analgesic, Anesthetic, and Addiction Clinical Trial Translations,
Innovations, Opportunities, and Networks (ACTTION); FDA; US Department
of Veteran Affairs; US National Institutes of Health
FX Preparation of the background literature reviews and draft manuscripts
was supported by the Analgesic, Anesthetic, and Addiction Clinical Trial
Translations, Innovations, Opportunities, and Networks (ACTTION);
public-private partnership with the US Food and Drug Administration
(FDA) ACTTION has received research contracts, grants, and other revenue
from the FDA, multiple pharmaceutical and device companies, and other
sources. No official endorsement by the FDA, US Department of Veteran
Affairs, US National Institutes of Health, or the pharmaceutical and
medical devices companies that have provided unrestricted grants to
support the activities of IMMPACT and ACTTION should be inferred.
NR 74
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U1 1
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0304-3959
EI 1872-6623
J9 PAIN
JI Pain
PD FEB
PY 2016
VL 157
IS 2
BP 288
EP 301
DI 10.1097/j.pain.0000000000000375
PG 14
WC Anesthesiology; Clinical Neurology; Neurosciences
SC Anesthesiology; Neurosciences & Neurology
GA DP1NV
UT WOS:000378257600004
PM 26683233
ER
PT J
AU Tartaglia, LJ
Chang, HW
Lee, BC
Abbink, P
Ng'ang'a, D
Boyd, M
Lavine, CL
Lim, SY
Sanisetty, S
Whitney, JB
Seaman, MS
Rolland, M
Tovanabutra, S
Ananworanich, J
Robb, ML
Kim, JH
Michael, NL
Barouch, DH
AF Tartaglia, Lawrence J.
Chang, Hui-Wen
Lee, Benjamin C.
Abbink, Peter
Ng'ang'a, David
Boyd, Michael
Lavine, Christy L.
Lim, So-Yon
Sanisetty, Srisowmya
Whitney, James B.
Seaman, Michael S.
Rolland, Morgane
Tovanabutra, Sodsai
Ananworanich, Jintanat
Robb, Merlin L.
Kim, Jerome H.
Michael, Nelson L.
Barouch, Dan H.
TI Production of Mucosally Transmissible SHIV Challenge Stocks from HIV-1
Circulating Recombinant Form 01_AE env Sequences
SO PLOS PATHOGENS
LA English
DT Article
ID VACCINE EFFICACY TRIAL; RHESUS-MONKEYS; VIRUS; NEUTRALIZATION;
INDUCTION; INFECTION; ASSAY; TIME
AB Simian-human immunodeficiency virus (SHIV) challenge stocks are critical for preclinical testing of vaccines, antibodies, and other interventions aimed to prevent HIV-1. A major unmet need for the field has been the lack of a SHIV challenge stock expressing circulating recombinant form 01_AE (CRF01_AE) env sequences. We therefore sought to develop mucosally transmissible SHIV challenge stocks containing HIV-1 CRF01_AE env derived from acutely HIV-1 infected individuals from Thailand. SHIV-AE6, SHIV-AE6RM, and SHIV-AE16 contained env sequences that were >99% identical to the original HIV-1 isolate and did not require in vivo passaging. These viruses exhibited CCR5 tropism and displayed a tier 2 neutralization phenotype. These challenge stocks efficiently infected rhesus monkeys by the intrarectal route, replicated to high levels during acute infection, and established chronic viremia in a subset of animals. SHIV-AE16 was titrated for use in single, high dose as well as repetitive, low dose intrarectal challenge studies. These SHIV challenge stocks should facilitate the preclinical evaluation of vaccines, monoclonal antibodies, and other interventions targeted at preventing HIV-1 CRF01_AE infection.
C1 [Tartaglia, Lawrence J.; Chang, Hui-Wen; Lee, Benjamin C.; Abbink, Peter; Ng'ang'a, David; Boyd, Michael; Lavine, Christy L.; Lim, So-Yon; Sanisetty, Srisowmya; Whitney, James B.; Seaman, Michael S.; Barouch, Dan H.] Beth Israel Deaconess Med Ctr, Ctr Virol & Vaccine Res, Boston, MA 02215 USA.
[Whitney, James B.; Seaman, Michael S.; Barouch, Dan H.] Ragon Inst MGH MIT & Harvard, Cambridge, MA USA.
[Rolland, Morgane; Tovanabutra, Sodsai; Ananworanich, Jintanat; Robb, Merlin L.; Kim, Jerome H.; Michael, Nelson L.] Walter Reed Army Inst Res, US Govt Mil HIV Res Program MHRP, Silver Spring, MD USA.
[Kim, Jerome H.] Int Vaccine Inst, Seoul, South Korea.
RP Barouch, DH (reprint author), Beth Israel Deaconess Med Ctr, Ctr Virol & Vaccine Res, Boston, MA 02215 USA.; Barouch, DH (reprint author), Ragon Inst MGH MIT & Harvard, Cambridge, MA USA.
EM dbarouch@bidmc.harvard.edu
RI Chang, Hui-Wen/C-9058-2017
OI Chang, Hui-Wen/0000-0001-8877-1886
FU Henry M. Jackson Foundation for the Advancement of Military Medicine
[W81XWH-11-2-0174]; U.S. Army Medical Research and Materiel Command
[W81XWH-11-2-0174]; National Institute of Allergy and Infectious
Diseases [AI096040, AI095985, AI078526]
FX This work was supported by a cooperative agreement (W81XWH-11-2-0174)
between the Henry M. Jackson Foundation for the Advancement of Military
Medicine and the U.S. Army Medical Research and Materiel Command. This
research was funded, in part, by the National Institute of Allergy and
Infectious Diseases (AI096040, AI095985, AI078526). The views expressed
are those of the authors and should not be construed to represent the
positions of the Department of the Army, Department of Defense, or the
National Institute of Allergy and Infectious Diseases. The funders had
no role in study design, data collection and analysis, decision to
publish, or preparation of the manuscript.
NR 22
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U1 0
U2 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1553-7366
EI 1553-7374
J9 PLOS PATHOG
JI PLoS Pathog.
PD FEB
PY 2016
VL 12
IS 2
AR e1005431
DI 10.1371/journal.ppat.1005431
PG 16
WC Microbiology; Parasitology; Virology
SC Microbiology; Parasitology; Virology
GA DP0BP
UT WOS:000378152900027
PM 26849216
ER
PT J
AU Kim, PY
Toblin, RL
Riviere, LA
Kok, BC
Grossman, SH
Wilk, JE
AF Kim, Paul Y.
Toblin, Robin L.
Riviere, Lyndon A.
Kok, Brian C.
Grossman, Sasha H.
Wilk, Joshua E.
TI Provider and Nonprovider Sources of Mental Health Help in the Military
and the Effects of Stigma, Negative Attitudes, and Organizational
Barriers to Care
SO PSYCHIATRIC SERVICES
LA English
DT Article
ID NATIONAL-GUARD SOLDIERS; COMBAT; DEPRESSION; SERVICES; CLERGY; PTSD;
VETERANS; DISORDER; SEEKING; SUPPORT
AB Objective: This study examined sources of help (providers or nonproviders) used by soldiers for mental health problems. Differences in perceived barriers to care by type of help used were also assessed.
Methods: Active-duty soldiers from four brigade combat teams (N=3,380) were surveyed in 2008-2009. Items assessed posttraumatic stress disorder; depression; anxiety; help needed because of a stress, emotional, alcohol, or family problem; stigma; negative attitudes toward care; and organizational barriers. Participants reported receipt of help in the past three months from providers (mental health or medical professionals or an Army resource hotline) or nonproviders (fellow soldier, medic, chaplain, or chain of command).
Results: Nearly a third (31%) were identified as being in need of mental health care. Of those, 5% reported using nonprovider help exclusively, 14% used provider help exclusively, and 7% used both types. Stigma was rated significantly lower as a barrier among those who used help exclusively from providers than among those who did not use help from any source; however, no significant differences in stigma scores were found between those who used help from nonproviders and those who did not use help from any source. Soldiers who used help from nonproviders were more likely than those who used help from providers to perceive organizational barriers.
Conclusions: Results show that soldiers may view nonproviders as alternative sources of mental health help, suggesting that the Army should ensure that such resources are adequately trained and integrated into the mental health community so that soldiers can receive the help they need.
C1 [Kim, Paul Y.; Riviere, Lyndon A.; Kok, Brian C.; Grossman, Sasha H.; Wilk, Joshua E.] US Army, Walter Reed Army Inst Res, Silver Spring, MD USA.
[Toblin, Robin L.] US Army, Walter Reed Army Inst Res, Res Transit Branch, Silver Spring, MD USA.
RP Kim, PY (reprint author), US Army, Walter Reed Army Inst Res, Silver Spring, MD USA.
EM paul.y.kim12.ctr@mail.mil
FU Military Operational Medicine Research Program, U.S. Army Medical
Research and Materiel Command
FX This study was supported by the Military Operational Medicine Research
Program, U.S. Army Medical Research and Materiel Command and by core
funding. The authors thank the Land Combat Study team for their support
with the data collection. Material was reviewed by the Walter Reed Army
Institute of Research; no objection was made to the presentation or
publication of these findings. The opinions or assertions are the
personal views of the authors and are not to be construed as official or
as reflecting the views of the U.S. Department of the Army or the U.S.
Department of Defense.
NR 27
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Z9 0
U1 2
U2 2
PU AMER PSYCHIATRIC PUBLISHING, INC
PI ARLINGTON
PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA
SN 1075-2730
EI 1557-9700
J9 PSYCHIAT SERV
JI Psychiatr. Serv.
PD FEB
PY 2016
VL 67
IS 2
BP 221
EP 226
DI 10.1176/appi.ps.201400519
PG 6
WC Health Policy & Services; Public, Environmental & Occupational Health;
Psychiatry
SC Health Care Sciences & Services; Public, Environmental & Occupational
Health; Psychiatry
GA DO4SZ
UT WOS:000377775400018
PM 26423099
ER
PT J
AU Tasissa, AF
Hautefeuille, M
Fitek, JH
Radovitzky, RA
AF Tasissa, Abiy F.
Hautefeuille, Martin
Fitek, John H.
Radovitzky, Raul A.
TI On the formation of Friedlander waves in a compressed-gas-driven shock
tube
SO PROCEEDINGS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING
SCIENCES
LA English
DT Article
DE blast waves; shock tubes; Friedlander waves
ID TRAUMATIC BRAIN-INJURY; BLAST; MODELS
AB Compressed-gas-driven shock tubes have become popular as a laboratory-scale replacement for field blast tests. The well-known initial structure of the Riemann problem eventually evolves into a shock structure thought to resemble a Friedlander wave, although this remains to be demonstrated theoretically. In this paper, we develop a semi-analytical model to predict the key characteristics of pseudo blast waves forming in a shock tube: location where the wave first forms, peak over-pressure, decay time and impulse. The approach is based on combining the solutions of the two different types of wave interactions that arise in the shock tube after the family of rarefaction waves in the Riemann solution interacts with the closed end of the tube. The results of the analytical model are verified against numerical simulations obtained with a finite volume method. The model furnishes a rational approach to relate shock tube parameters to desired blast wave characteristics, and thus constitutes a useful tool for the design of shock tubes for blast testing.
C1 [Tasissa, Abiy F.; Hautefeuille, Martin; Radovitzky, Raul A.] MIT, Dept Aeronaut & Astronaut, Inst Solider Nanotechnol, Cambridge, MA 02139 USA.
[Fitek, John H.] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA.
RP Radovitzky, RA (reprint author), MIT, Dept Aeronaut & Astronaut, Inst Solider Nanotechnol, Cambridge, MA 02139 USA.
EM rapa@mit.edu
FU US Army Research Laboratory; US Army Research Office through Institute
for Soldier Nanotechnologies [W911NF-13-D-0001]
FX This work was supported by the US Army Research Laboratory and the US
Army Research Office through the Institute for Soldier Nanotechnologies,
under contract no. W911NF-13-D-0001.
NR 27
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Z9 0
U1 4
U2 4
PU ROYAL SOC
PI LONDON
PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND
SN 1364-5021
EI 1471-2946
J9 P ROY SOC A-MATH PHY
JI Proc. R. Soc. A-Math. Phys. Eng. Sci.
PD FEB 1
PY 2016
VL 472
IS 2186
AR 20150611
DI 10.1098/rspa.2015.0611
PG 24
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DO3ZC
UT WOS:000377720300008
PM 27118888
ER
PT J
AU Kirwin, P
Conroy, M
Lyketsos, C
Greenwald, B
Forester, B
deVries, C
Ahmed, II
Wiechers, I
Zdanys, K
Steffens, D
Reynolds, CF
AF Kirwin, Paul
Conroy, Michelle
Lyketsos, Constantine
Greenwald, Blaine
Forester, Brent
deVries, Christine
Ahmed, Iqbal Ike
Wiechers, Ilse
Zdanys, Kristina
Steffens, David
Reynolds, Charles F., II
TI A Call to Restructure Psychiatry General and Subspecialty Training
SO ACADEMIC PSYCHIATRY
LA English
DT Article
DE Residency education; Fellowship training; Subspecialty training; ACGME;
ABPN
AB Dire shortages of psychiatrists with special expertise in geriatrics, substance abuse, forensics, and psychosomatics create barriers to care for populations with complex mental disorders and pose a significant public health concern. To address these disparities in access to care, we propose streamlining graduate medical education to increase efficiency and enhance cost-effectiveness while simultaneously increasing the number ofpsychiatric subspecialists in these key areas. We propose that trainees interested in subspecialties complete their general training in 3 years, while meeting ACGME required milestones, and then utilize their 4th year to complete subspecialty fellowship training. Eligible trainees would then qualify' for psychiatry subspecialty certification and general psychiatry ABPN certification at the end of 4 years.
C1 [Kirwin, Paul; Conroy, Michelle; Wiechers, Ilse] Yale Univ, Sch Med, VA Connecticut Healthcare Syst, West Haven, CT 06516 USA.
[Lyketsos, Constantine] Johns Hopkins Univ Hosp, Baltimore, MD 21287 USA.
[Greenwald, Blaine] N Shore Univ Hosp, Long Isl Jewish Med Ctr, Glen Oaks, NY USA.
[Forester, Brent] Harvard Univ, McLean Hosp, Sch Med, Belmont, MA USA.
[deVries, Christine] Amer Assoc Geriatr Psychiat, Bethesda, MD USA.
[Ahmed, Iqbal Ike] Tripler Army Med Ctr, Honolulu, HI 96859 USA.
[Zdanys, Kristina] Univ Connecticut, Ctr Hlth, Farmington, CT USA.
[Steffens, David] Univ Connecticut, Sch Med, Farmington, CT USA.
[Reynolds, Charles F., II] Univ Pittsburgh, Med Ctr, Pittsburgh, PA USA.
RP Kirwin, P (reprint author), Yale Univ, Sch Med, VA Connecticut Healthcare Syst, West Haven, CT 06516 USA.
EM Paul.Kirwin@yale.edu
NR 11
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1042-9670
EI 1545-7230
J9 ACAD PSYCHIATR
JI Acad. Psych.
PD FEB
PY 2016
VL 40
IS 1
BP 145
EP 148
DI 10.1007/s40596-014-0144-5
PG 4
WC Education & Educational Research; Psychiatry
SC Education & Educational Research; Psychiatry
GA DN5HL
UT WOS:000377097100027
PM 24809688
ER
PT J
AU Lemasson, BH
Tanner, CJ
Dimperio, E
AF Lemasson, Bertrand H.
Tanner, Colby J.
Dimperio, Eric
TI A Sensory-Driven Trade-Off between Coordinated Motion in Social Prey and
a Predator's Visual Confusion
SO PLOS COMPUTATIONAL BIOLOGY
LA English
DT Article
ID INFORMATION-TRANSFER; EYE-MOVEMENTS; FISH; BEHAVIOR; PURSUIT;
PERCEPTION; SMOOTH; HUMANS; BACKGROUNDS; REGRESSION
AB Social animals are capable of enhancing their awareness by paying attention to their neighbors, and prey found in groups can also confuse their predators. Both sides of these sensory benefits have long been appreciated, yet less is known of how the perception of events from the perspectives of both prey and predator can interact to influence their encounters. Here we examined how a visual sensory mechanism impacts the collective motion of prey and, subsequently, how their resulting movements influenced predator confusion and capture ability. We presented virtual prey to human players in a targeting game and measured the speed and accuracy with which participants caught designated prey. As prey paid more attention to neighbor movements their collective coordination increased, yet increases in prey coordination were positively associated with increases in the speed and accuracy of attacks. However, while attack speed was unaffected by the initial state of the prey, accuracy dropped significantly if the prey were already organized at the start of the attack, rather than in the process of self-organizing. By repeating attack scenarios and masking the targeted prey's neighbors we were able to visually isolate them and conclusively demonstrate how visual confusion impacted capture ability. Delays in capture caused by decreased coordination amongst the prey depended upon the collection motion of neighboring prey, while it was primarily the motion of the targets themselves that determined capture accuracy. Interestingly, while a complete loss of coordination in the prey (e.g., a flash expansion) caused the greatest delay in capture, such behavior had little effect on capture accuracy. Lastly, while increases in collective coordination in prey enhanced personal risk, traveling in coordinated groups was still better than appearing alone. These findings demonstrate a trade-off between the sensory mechanisms that can enhance the collective properties that emerge in social animals and the individual group member's predation risk during an attack.
C1 [Lemasson, Bertrand H.; Dimperio, Eric] US Army, ERDC, Environm Lab, Santa Barbara, CA USA.
[Tanner, Colby J.] Univ Lausanne, Dept Ecol, CH-1015 Lausanne, Switzerland.
[Lemasson, Bertrand H.] Environm Lab ERDC, Newport, OR USA.
[Tanner, Colby J.] Univ Nebraska, Sch Biol Sci, Lincoln, NE USA.
[Dimperio, Eric] Corios LLC, Portland, OR USA.
RP Lemasson, BH (reprint author), US Army, ERDC, Environm Lab, Santa Barbara, CA USA.; Lemasson, BH (reprint author), Environm Lab ERDC, Newport, OR USA.
EM brilraven@gmail.com
FU ERDC's Environmental Laboratory's EQ/I Basic Research Program
[BT25-NS/12-64]; Marie Curie Fellowship
FX BHL and ED were supported by ERDC's Environmental Laboratory's EQ/I
Basic Research Program, Grant #: BT25-NS/12-64
(http://www.erdc.usace.army.mil/Locations/Environmenta vertical bar
Laboratory.aspx) CJT was supported by a Marie Curie Fellowship
(http://research.ie/scheme/inspire-postdoctoral-fellowship-scheme). The
funders had no role in study design, data collection and analysis,
decision to publish, or preparation of the manuscript.
NR 59
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U1 0
U2 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1553-734X
EI 1553-7358
J9 PLOS COMPUT BIOL
JI PLoS Comput. Biol.
PD FEB
PY 2016
VL 12
IS 2
AR e1004708
DI 10.1371/journal.pcbi.1004708
PG 20
WC Biochemical Research Methods; Mathematical & Computational Biology
SC Biochemistry & Molecular Biology; Mathematical & Computational Biology
GA DM8AL
UT WOS:000376582900013
PM 26914768
ER
PT J
AU Kaini, RR
Shen-Gunther, J
Cleland, JM
Greene, WA
Wang, HC
AF Kaini, Ramesh R.
Shen-Gunther, Jane
Cleland, Jeffery M.
Greene, Whitney A.
Wang, Heuy-Ching
TI Recombinant Xeno-Free Vitronectin Supports Self-Renewal and Pluripotency
in Protein-Induced Pluripotent Stem Cells
SO TISSUE ENGINEERING PART C-METHODS
LA English
DT Article
ID EXTRACELLULAR-MATRIX; SOMATIC-CELLS; FREE CULTURE; GENERATION; LINES;
DERIVATION; EXPANSION; THERAPY; FATE
AB Patient safety is a major concern in the application of induced pluripotent stem cells (iPSCs) in cell-based therapy. Efforts are being made to reprogram, maintain, and differentiate iPSCs in defined conditions to provide a safe source of stem cells for regenerative medicine. Recently, human fibroblasts were successfully reprogrammed into pluripotent stem cells using four recombinant proteins (OCT4, c-Myc, KLF4, and SOX2) fused with a cell-penetrating peptide (9R). These protein-induced pluripotent stem cells (piPSCs) are maintained and propagated on a feeder layer of mouse embryonic fibroblasts. Use of animal-derived products in maintenance and differentiation of iPSCs poses risks of zoonotic disease transmission and immune rejection when transplanted into humans. To avoid potential incorporation of xenogenic products, we cultured piPSCs on recombinant human matrix proteins. We then tested whether recombinant human matrix proteins can support self-renewal and pluripotency of piPSCs. After long-term culture on recombinant human vitronectin in xeno-free conditions, piPSCs retained the expression of pluripotent markers. The pluripotency of these cells was further evaluated by differentiating toward ectoderm, mesoderm, and endoderm lineages in vitro. In conclusion, recombinant human vitronectin can support the long-term culture and maintain the stemness of piPSCs in defined nonxenogenic conditions.
C1 [Kaini, Ramesh R.; Cleland, Jeffery M.; Greene, Whitney A.; Wang, Heuy-Ching] US Army, Inst Surg Res, Ocular Trauma Task Area, 3698 Chamber Pass,Bldg 3611, Jbsa Ft Sam Houston, TX 78234 USA.
[Shen-Gunther, Jane] Brooke Army Med Ctr, Dept Clin Invest, Div Gynecol Oncol, 3698 Chamber Pass,Bldg 3611, Jbsa Ft Sam Houston, TX 78234 USA.
RP Wang, HC (reprint author), US Army, Inst Surg Res, Ocular Trauma Task Area, 3698 Chamber Pass,Bldg 3611, Jbsa Ft Sam Houston, TX 78234 USA.
EM heuy-ching.h.wang.civ@mail.mil
FU U.S. Army Clinical Rehabilitative Medicine Research Program (CRMRP);
Military Operational Medicine Research Program (MOMRP)
FX We thank Mr. Dallas Golden for supporting tissue culture works and Mr.
Luis Perez for confocal microscopy. This work was supported by U.S. Army
Clinical Rehabilitative Medicine Research Program (CRMRP) and Military
Operational Medicine Research Program (MOMRP) to H.-C.W. R.R.K. is a
National Research Council Research Associate.
NR 48
TC 1
Z9 1
U1 4
U2 4
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1937-3384
EI 1937-3392
J9 TISSUE ENG PART C-ME
JI Tissue Eng. Part C-Methods
PD FEB
PY 2016
VL 22
IS 2
BP 85
EP 90
DI 10.1089/ten.tec.2015.0180
PG 6
WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell
Biology
SC Cell Biology; Biotechnology & Applied Microbiology
GA DM4AP
UT WOS:000376288200001
ER
PT J
AU Greene, AE
McGeeney, RJ
AF Greene, Amy Elise
McGeeney, Robert J.
TI Many shades of guilt
SO CLEVELAND CLINIC JOURNAL OF MEDICINE
LA English
DT Editorial Material
C1 [Greene, Amy Elise] Cleveland Clin, Spiritual Care, Q1-101,9500 Euclid Ave, Cleveland, OH 44195 USA.
[McGeeney, Robert J.] Cleveland Clin, Clin Pastoral Educ, Cleveland, OH 44195 USA.
[McGeeney, Robert J.] US Army Reserve, Ft Bragg, NC USA.
RP Greene, AE (reprint author), Cleveland Clin, Spiritual Care, Q1-101,9500 Euclid Ave, Cleveland, OH 44195 USA.
EM greenea3@ccf.org
NR 4
TC 0
Z9 0
U1 0
U2 0
PU CLEVELAND CLINIC
PI CLEVELAND
PA 9500 EUCLID AVE, CLEVELAND, OH 44106 USA
SN 0891-1150
EI 1939-2869
J9 CLEV CLIN J MED
JI Clevel. Clin. J. Med.
PD FEB
PY 2016
VL 83
IS 2
BP 106
EP 108
DI 10.3949/ccjm.83a.15136
PG 3
WC Medicine, General & Internal
SC General & Internal Medicine
GA DK3TR
UT WOS:000374840800007
PM 26871386
ER
PT J
AU Kosisky, SE
Banks, TA
Spriet, SW
AF Kosisky, Susan E.
Banks, Taylor A.
Spriet, Sarah W.
TI Daily Fluctuations in Airborne Ragweed Pollen Levels in Washington, DC
(2007-2009)
SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology
(AAAAI)
CY MAR 04-07, 2016
CL Los Angeles, CA
SP Amer Acad Allergy, Asthma & Immunol
C1 [Kosisky, Susan E.] US Army, Centralized Allergen Extract Lab, Burtonsville, MD USA.
[Banks, Taylor A.; Spriet, Sarah W.] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0091-6749
EI 1097-6825
J9 J ALLERGY CLIN IMMUN
JI J. Allergy Clin. Immunol.
PD FEB
PY 2016
VL 137
IS 2
SU S
MA 396
BP AB121
EP AB121
PG 1
WC Allergy; Immunology
SC Allergy; Immunology
GA DK6BI
UT WOS:000375005402086
ER
PT J
AU Schultz, NE
Ahmad, R
Brennan, JK
Frankel, KA
Moore, JD
Moore, JD
Mountain, RD
Ross, RB
Thommes, M
Shen, VK
Siderius, DW
Smith, KD
AF Schultz, Nathan E.
Ahmad, Riaz
Brennan, John K.
Frankel, Kevin A.
Moore, Jonathan D.
Moore, Joshua D.
Mountain, Raymond D.
Ross, Richard B.
Thommes, Matthias
Shen, Vincent K.
Siderius, Daniel W.
Smith, Kenneth D.
TI The Eighth Industrial Fluids Properties Simulation Challenge
SO ADSORPTION SCIENCE & TECHNOLOGY
LA English
DT Article
DE Molecular simulation; activated carbon; adsorption; perfluorohexane;
organic compounds
ID VAPOR-LIQUID-EQUILIBRIA; MOLECULAR-DYNAMICS SIMULATION; MONTE-CARLO
SIMULATIONS; GLYCOL DIMETHYL ETHER; HENRYS LAW CONSTANTS; BUBBLE POINT
PRESSURE; FORCE-FIELD; PREDICTING ADSORPTION; ETHYLENE-OXIDE;
PERFLUOROHEXANE ADSORPTION
AB The goal of the eighth industrial fluid properties simulation challenge was to test the ability of molecular simulation methods to predict the adsorption of organic adsorbates in activated carbon materials. In particular, the eighth challenge focused on the adsorption of perfluorohexane in the activated carbon BAM-P109. Entrants were challenged to predict the adsorption in the carbon at 273 K and relative pressures of 0.1, 0.3, and 0.6. The predictions were judged by comparison with a benchmark set of experimentally determined values. Overall, good agreement and consistency were found between the predictions of most entrants.
C1 [Schultz, Nathan E.; Frankel, Kevin A.; Ross, Richard B.] 3M Co, Ctr 3M, 201-2E-23, St Paul, MN 55144 USA.
[Ahmad, Riaz; Thommes, Matthias] Quantachrome Instruments, Boynton Beach, FL USA.
[Brennan, John K.; Moore, Joshua D.] US Army, Res Lab, Aberdeen Proving Ground, MD USA.
[Moore, Jonathan D.] Dow Chem Co USA, Midland, MI 48674 USA.
[Mountain, Raymond D.; Shen, Vincent K.; Siderius, Daniel W.] NIST, Gaithersburg, MD 20899 USA.
[Smith, Kenneth D.] United Technol Res Ctr, E Hartford, CT 06108 USA.
RP Ross, RB (reprint author), 3M Co, Ctr 3M, 201-2E-23, St Paul, MN 55144 USA.
EM rbross@mmm.com
RI Moore, Jonathan/B-8201-2009
FU 3M Company; BP Amoco; Dow Chemical Company; DuPont; Exxon Mobil;
Mitsubishi Chemical Corporation
FX The author(s) disclosed receipt of the following financial support for
the research, authorship, and/or publication of this article: We would
like to thank the 3M Company, BP Amoco, The Dow Chemical Company,
DuPont, Exxon Mobil, and Mitsubishi Chemical Corporation for their
financial support.
NR 64
TC 0
Z9 0
U1 1
U2 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0263-6174
EI 2048-4038
J9 ADSORPT SCI TECHNOL
JI Adsorpt. Sci. Technol.
PD FEB
PY 2016
VL 34
IS 1
SI SI
BP 3
EP 12
DI 10.1177/0263617415619521
PG 10
WC Chemistry, Applied; Chemistry, Physical; Engineering, Chemical
SC Chemistry; Engineering
GA DJ5ZL
UT WOS:000374289400001
PM 27840542
ER
PT J
AU Ross, RB
Aeschliman, DB
Ahmad, R
Brennan, JK
Brostrom, ML
Frankel, KA
Moore, JD
Moore, JD
Mountain, RD
Poirier, DM
Thommes, M
Shen, VK
Schultz, NE
Siderius, DW
Smith, KD
AF Ross, Richard B.
Aeschliman, David B.
Ahmad, Riaz
Brennan, John K.
Brostrom, Myles L.
Frankel, Kevin A.
Moore, Jonathan D.
Moore, Joshua D.
Mountain, Raymond D.
Poirier, Derrick M.
Thommes, Matthias
Shen, Vincent K.
Schultz, Nathan E.
Siderius, Daniel W.
Smith, Kenneth D.
TI Adsorption, X-ray diffraction, photoelectron, and atomic emission
spectroscopy benchmark studies for the eighth industrial fluid
properties simulation challenge
SO ADSORPTION SCIENCE & TECHNOLOGY
LA English
DT Article
DE Perfluorohexane; adsorption; activated carbon; BAM-P109 activated carbon
AB The primary goal of the eighth industrial fluid properties simulation challenge was to test the ability of molecular simulation methods to predict the adsorption of organic adsorbates in activated carbon materials. The challenge focused on the adsorption of perfluorohexane in the activated carbon standard BAM-P109. Entrants were challenged to predict the adsorption of perfluorohexane in the activated carbon at a temperature of 273K and at relative pressures of 0.1, 0.3, and 0.6. The relative pressure (P/P-o) is defined as that relative to the bulk saturation pressure predicted by the fluid model at a given temperature (273K in this case). The predictions were judged by comparison to a set of experimentally determined values, which are published here for the first time and were not disclosed to the entrants prior to the challenge. Benchmark experimental studies, described herein, were also carried out and provided to entrants in order to aid in the development of new force fields and simulation methods to be employed in the challenge. These studies included argon, carbon dioxide, and water adsorption in the BAM-P109 activated carbon as well as X-ray diffraction, X-ray microtomography, photoelectron spectroscopy, and atomic emission spectroscopy studies of BAM-P109. Several concurrent studies were carried out for the BAM-P108 activated carbon. These are included in the current manuscript for comparison.
C1 [Ross, Richard B.; Aeschliman, David B.; Brostrom, Myles L.; Frankel, Kevin A.; Poirier, Derrick M.; Schultz, Nathan E.] 3M Co, St Paul, MN 55144 USA.
[Ahmad, Riaz; Thommes, Matthias] Quantachrome Instruments, Boynton Beach, FL USA.
[Brennan, John K.; Moore, Joshua D.] US Army, Weap & Mat Res Directorate, Res Lab, Aberdeen Proving Ground, MD USA.
[Moore, Jonathan D.] Dow Chem Co USA, Midland, MI 48674 USA.
[Mountain, Raymond D.; Shen, Vincent K.; Siderius, Daniel W.] NIST, Gaithersburg, MD 20899 USA.
[Smith, Kenneth D.] United Technol Res Ctr, E Hartford, CT 06108 USA.
RP Ross, RB (reprint author), 3M Co, St Paul, MN 55144 USA.
EM rbross@mmm.com
RI Moore, Jonathan/B-8201-2009
FU Intramural NIST DOC [9999-NIST]
NR 15
TC 3
Z9 3
U1 3
U2 6
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0263-6174
EI 2048-4038
J9 ADSORPT SCI TECHNOL
JI Adsorpt. Sci. Technol.
PD FEB
PY 2016
VL 34
IS 1
SI SI
BP 13
EP 41
DI 10.1177/0263617415619541
PG 29
WC Chemistry, Applied; Chemistry, Physical; Engineering, Chemical
SC Chemistry; Engineering
GA DJ5ZL
UT WOS:000374289400002
PM 27840543
ER
PT J
AU Kube, CM
Turner, JA
AF Kube, Christopher M.
Turner, Joseph A.
TI Stress-dependent ultrasonic scattering in polycrystalline materials
SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
LA English
DT Article
ID RESIDUAL-STRESSES; WAVE PROPAGATION; ACOUSTOELASTICITY; BACKSCATTER;
ALUMINUM; TEXTURE; MICROSTRUCTURE; DEFORMATION; ATTENUATION; CRYSTALS
AB Stress-dependent elastic moduli of polycrystalline materials are used in a statistically based model for the scattering of ultrasonic waves from randomly oriented grains that are members of a stressed polycrystal. The stress is assumed to be homogeneous and can be either residual or generated from external loads. The stress-dependent elastic properties are incorporated into the definition of the differential scattering cross-section, which defines how strongly an incident wave is scattered into various directions. Nine stress-dependent differential scattering cross-sections or scattering coefficients are defined to include all possibilities of incident and scattered waves, which can be either longitudinal or (two) transverse wave types. The evaluation of the scattering coefficients considers polycrystalline aluminum that is uniaxially stressed. An analysis of the influence of incident wave propagation direction, scattering direction, frequency, and grain size on the stress-dependency of the scattering coefficients follows. Scattering coefficients for aluminum indicate that ultrasonic scattering is much more sensitive to a uniaxial stress than ultrasonic phase velocities. By developing the stress-dependent scattering properties of polycrystals, the influence of acoustoelasticity on the amplitudes of waves propagating in stressed polycrystalline materials can be better understood. This work supports the ongoing development of a technique for monitoring and measuring stresses in metallic materials. (C) 2016 Acoustical Society of America.
C1 [Kube, Christopher M.; Turner, Joseph A.] Univ Nebraska, Dept Mech & Mat Engn, W342 Nebraska Hall, Lincoln, NE 68588 USA.
[Kube, Christopher M.] Army Res Lab, Mech Div, Vehicle Technol Directorate, 4603 Flare Loop, Aberdeen Proving Ground, MD 21005 USA.
RP Kube, CM (reprint author), Univ Nebraska, Dept Mech & Mat Engn, W342 Nebraska Hall, Lincoln, NE 68588 USA.; Kube, CM (reprint author), Army Res Lab, Mech Div, Vehicle Technol Directorate, 4603 Flare Loop, Aberdeen Proving Ground, MD 21005 USA.
EM ckube@huskers.unl.edu
RI Turner, Joseph/F-5165-2010
NR 47
TC 0
Z9 0
U1 3
U2 7
PU ACOUSTICAL SOC AMER AMER INST PHYSICS
PI MELVILLE
PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA
SN 0001-4966
EI 1520-8524
J9 J ACOUST SOC AM
JI J. Acoust. Soc. Am.
PD FEB
PY 2016
VL 139
IS 2
BP 811
EP 824
DI 10.1121/1.4941253
PG 14
WC Acoustics; Audiology & Speech-Language Pathology
SC Acoustics; Audiology & Speech-Language Pathology
GA DI7TQ
UT WOS:000373705300028
PM 26936563
ER
PT J
AU Dent, AE
Malhotra, I
Wang, XL
Babineau, D
Yeo, KT
Anderson, T
Kimmel, RJ
Angov, E
Lanar, DE
Narum, D
Dutta, S
Richards, J
Beeson, JG
Crabb, BS
Cowman, AF
Horii, T
Muchiri, E
Mungai, PL
King, CL
Kazura, JW
AF Dent, Arlene E.
Malhotra, Indu
Wang, Xuelie
Babineau, Denise
Yeo, Kee Thai
Anderson, Timothy
Kimmel, Rhonda J.
Angov, Evelina
Lanar, David E.
Narum, David
Dutta, Sheetij
Richards, Jack
Beeson, James G.
Crabb, Brendan S.
Cowman, Alan F.
Horii, Toshihiro
Muchiri, Eric
Mungai, Peter L.
King, Christopher L.
Kazura, James W.
TI Contrasting Patterns of Serologic and Functional Antibody Dynamics to
Plasmodium falciparum Antigens in a Kenyan Birth Cohort
SO CLINICAL AND VACCINE IMMUNOLOGY
LA English
DT Article
ID MEROZOITE SURFACE PROTEIN-1; APICAL MEMBRANE ANTIGEN-1;
INVASION-INHIBITORY ANTIBODIES; IN-VITRO GROWTH; ERYTHROCYTE-BINDING
ANTIGENS; NATURALLY ACQUIRED-IMMUNITY; INFECTED ERYTHROCYTES; MALARIA
VACCINE; ESCHERICHIA-COLI; AOTUS-NANCYMAI
AB IgG antibodies to Plasmodium falciparum are transferred from the maternal to fetal circulation during pregnancy, wane after birth, and are subsequently acquired in response to natural infection. We examined the dynamics of malaria antibody responses of 84 Kenyan infants from birth to 36 months of age by (i) serology, (ii) variant surface antigen (VSA) assay, (iii) growth inhibitory activity (GIA), and (iv) invasion inhibition assays (IIA) specific for merozoite surface protein 1 (MSP1) and sialic acid-dependent invasion pathway. Maternal antibodies in each of these four categories were detected in cord blood and decreased to their lowest level by approximately 6 months of age. Serologic antibodies to 3 preerythrocytic and 10 blood-stage antigens subsequently increased, reaching peak prevalence by 36 months. In contrast, antibodies measured by VSA, GIA, and IIA remained low even up to 36 months. Infants sensitized to P. falciparum in utero, defined by cord blood lymphocyte recall responses to malaria antigens, acquired antimalarial antibodies at the same rate as those who were not sensitized in utero, indicating that fetal exposure to malaria antigens did not affect subsequent infant antimalarial responses. Infants with detectable serologic antibodies at 12 months of age had an increased risk of P. falciparum infection during the subsequent 24 months. We conclude that serologic measures of antimalarial antibodies in children 36 months of age or younger represent biomarkers of malaria exposure rather than protection and that functional antibodies develop after 36 months of age in this population.
C1 [Dent, Arlene E.; Malhotra, Indu; Kimmel, Rhonda J.; Mungai, Peter L.; King, Christopher L.; Kazura, James W.] Case Western Reserve Univ, Ctr Global Hlth & Dis, Cleveland, OH 44106 USA.
[Dent, Arlene E.; Yeo, Kee Thai] Rainbow Babies & Childrens Hosp, Dept Pediat, Cleveland, OH 44106 USA.
[Wang, Xuelie; Babineau, Denise] Case Western Reserve Univ, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA.
[Anderson, Timothy] Case Western Reserve Univ, Sch Med, Cleveland, OH USA.
[Angov, Evelina; Lanar, David E.; Dutta, Sheetij] Walter Reed Army Inst Res, Malaria Vaccine Branch, Silver Spring, MD USA.
[Narum, David] NIAID, Lab Malaria Immunol & Vaccinol, NIH, Rockville, MD USA.
[Richards, Jack; Beeson, James G.; Crabb, Brendan S.] Burnet Inst, Melbourne, Vic, Australia.
[Beeson, James G.] Monash Univ, Dept Microbiol, Melbourne, Vic 3004, Australia.
[Cowman, Alan F.] Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia.
[Horii, Toshihiro] Osaka Univ, Microbial Dis Res Inst, Dept Mol Protozool, Suita, Osaka 565, Japan.
[Muchiri, Eric; Mungai, Peter L.] Minist Publ Hlth & Sanitat, Div Vector Borne & Neglected Trop Dis, Nairobi, Kenya.
[Babineau, Denise] Rho Fed Syst Div, Chapel Hill, NC USA.
[Anderson, Timothy] Univ Pittsburgh, Med Ctr, Dept Med, Pittsburgh, PA USA.
RP Dent, AE (reprint author), Case Western Reserve Univ, Ctr Global Hlth & Dis, Cleveland, OH 44106 USA.; Dent, AE (reprint author), Rainbow Babies & Childrens Hosp, Dept Pediat, Cleveland, OH 44106 USA.
EM arlene.dent@case.edu
FU HHS \ NIH \ National Institute of Allergy and Infectious Diseases
(NIAID) [AI098511, AI064667, AI09519]
FX HHS vertical bar NIH vertical bar National Institute of Allergy and
Infectious Diseases (NIAID) provided funding to Arlene E. Dent under
grant number AI098511. HHS vertical bar NIH vertical bar National
Institute of Allergy and Infectious Diseases (NIAID) provided funding to
Christopher L. King under grant number AI064667. HHS vertical bar NIH
vertical bar National Institute of Allergy and Infectious Diseases
(NIAID) provided funding to James W. Kazura under grant number AI09519.
NR 92
TC 2
Z9 2
U1 3
U2 3
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 1556-6811
EI 1556-679X
J9 CLIN VACCINE IMMUNOL
JI Clin. Vaccine Immunol.
PD FEB
PY 2016
VL 23
IS 2
BP 104
EP 116
DI 10.1128/CVI.00452-15
PG 13
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA DI4SI
UT WOS:000373489200004
PM 26656119
ER
PT J
AU Chiles, DP
Roberts, TA
Klein, DA
AF Chiles, Daniel P.
Roberts, Timothy A.
Klein, David A.
TI LONG-ACTING REVERSIBLE CONTRACEPTION UPTAKE AND CONTINUATION IN A
UNIVERSAL HEALTHCARE SYSTEM
SO JOURNAL OF ADOLESCENT HEALTH
LA English
DT Meeting Abstract
C1 [Chiles, Daniel P.] US Army, Washington, DC USA.
[Roberts, Timothy A.; Klein, David A.] US Air Force, Washington, DC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1054-139X
EI 1879-1972
J9 J ADOLESCENT HEALTH
JI J. Adolesc. Health
PD FEB
PY 2016
VL 58
IS 2
SU S
MA 152
BP S79
EP S80
PG 3
WC Psychology, Developmental; Public, Environmental & Occupational Health;
Pediatrics
SC Psychology; Public, Environmental & Occupational Health; Pediatrics
GA DI3VW
UT WOS:000373428800153
ER
PT J
AU Fielitz, L
Coelho, J
Horne, T
Brechue, W
AF Fielitz, Lynn
Coelho, Jeffrey
Horne, Thomas
Brechue, William
TI Inter-Rater Reliability and Intra-Rater Reliability of Assessing the
2-Minute Push-Up Test
SO MILITARY MEDICINE
LA English
DT Article
ID EXERCISE; VALIDITY
AB The purpose of this study was to assess inter-rater reliability and intra-rater reliability of the 2-minute, 90 degrees push-up test as utilized in the Army Physical Fitness Test. Analysis of rater assessment reliability included both total score agreement and agreement across individual push-up repetitions. This study utilized 8 Raters who assessed 15 different videotaped push-up performances over 4 iterations separated by a minimum of 1 week. The 15 push-up participants were videotaped during the semiannual Army Physical Fitness Test. Each Rater randomly viewed the 15 push-up and verbally responded with a "yes" or "no" to each push-up repetition. The data generated were analyzed using the Pearson product-moment correlation as well as the kappa, modified kappa and the intra-class correlation coefficient (3,1). An attribute agreement analysis was conducted to determine the percent of inter-rater and intra-rater agreement across individual push-ups. The results indicated that Raters varied a great deal in assessing push-ups. Over the 4 trials of 15 participants, the overall scores of the Raters varied between 3.0 and 35.7 push-ups. Post hoc comparisons found that there was significant increase in the grand mean of push-ups from trials 1-3 to trial 4 (p < 0.05). Also, there was a significant difference among raters over the 4 trials (p < 0.05). Pearson correlation coefficients for inter-rater and intra-rater reliability identified inter-rater reliability coefficients were between 0.10 and 0.97. Intra-rater coefficients were between 0.48 and 0.99. Intra-rater agreement for individual push-up repetitions ranged from 41.8% to 84.8%. The results indicated that the raters failed to assess the same push-up repetition with the same score (below 70% agreement) as well as failed to agree when viewed between raters (29%). Interestingly, as previously mentioned, scores on trial 4 increased significantly which might have been caused by rater drift or that the Raters did not maintain the push-up standard over the trials. It does appear that the final push-up scores received by each participant was a close approximation of actual performance (within 65%) but when assessing physical performance for retention in the Army, a more reliable test might be considered.
C1 [Fielitz, Lynn; Coelho, Jeffrey; Horne, Thomas; Brechue, William] US Mil Acad, Dept Phys Educ, 727 Brewerton Rd, West Point, NY 10996 USA.
RP Fielitz, L (reprint author), US Mil Acad, Dept Phys Educ, 727 Brewerton Rd, West Point, NY 10996 USA.
NR 25
TC 0
Z9 0
U1 0
U2 2
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD FEB
PY 2016
VL 181
IS 2
BP 167
EP 172
DI 10.7205/MILMED-D-14-00533
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA DI3ND
UT WOS:000373404500019
PM 26837086
ER
PT J
AU Abt, JP
Perlsweig, K
Nagai, T
Sell, TC
Wirt, MD
Lephart, SM
AF Abt, John P.
Perlsweig, Katherine
Nagai, Takashi
Sell, Timothy C.
Wirt, Michael D.
Lephart, Scott M.
TI Effects of Age and Military Service on Strength and Physiological
Characteristics of US Army Soldiers
SO MILITARY MEDICINE
LA English
DT Article
ID TRAINING-RELATED INJURIES; MAXIMAL HEART-RATE; PHYSICAL-FITNESS;
RISK-FACTORS; OPERATIONAL STRESS; AEROBIC CAPACITY; BODY-COMPOSITION;
SEDENTARY MEN; PERFORMANCE; RELIABILITY
AB Soldiers must maintain tactical performance capabilities over the course of their career. Loss in physical readiness may be a function of age and the operational demands associated with increasing years of service. The purpose of this study was to assess strength and physiological characteristics in different cohorts of U.S. Army Soldiers based on years of service and age. A total of 253 Soldiers (age: 28.1 +/- 6.8 years; height: 1.76 +/- 0.11 m; mass: 84.1 +/- 12.2 kg) participated. Individual subject cohorts were created based on years of service (1-5 years, 6-10 years, 11-15 years) and age (20-24 years, 25-29 years, 30-34 years, 35-39 years, 40-44 years). Testing included shoulder, knee, ankle, and torso strength, aerobic capacity/lactate threshold, anaerobic power/capacity, and body composition/total mass. Those with 11 to 15 years of service and between ages 30 and 34 had a higher percentage of body fat, and lower aerobic capacity and lactate threshold than younger Soldiers with fewer years of service. Physical training interventions should focus on maintenance of physiological characteristics to offset the loss of readiness at the similar time point of 11 to 15 years of service and 30 to 34 years of age.
C1 [Abt, John P.; Lephart, Scott M.] Univ Kentucky, Coll Hlth Sci, UK Wethington Bldg,Room 123,900 South Limestone, Lexington, KY 40536 USA.
[Perlsweig, Katherine; Nagai, Takashi; Sell, Timothy C.] Univ Pittsburgh, Neuromuscular Res Lab, Warrior Human Performance Res Ctr, 3830 South Water St, Pittsburgh, PA 15203 USA.
[Wirt, Michael D.] US Army Inst Surg Res, 3698 Chambers Pass,Bldg 36111, Jbsa Ft Sam Houston, TX 78234 USA.
RP Abt, JP (reprint author), Univ Kentucky, Coll Hlth Sci, UK Wethington Bldg,Room 123,900 South Limestone, Lexington, KY 40536 USA.
FU U.S. Army Medical Research and Materiel Command [W81XWH-11-2-0097]
FX This work was supported by the U.S. Army Medical Research and Materiel
Command No. W81XWH-11-2-0097. Opinions, interpretations, conclusions,
and recommendations are those of the authors and not necessarily
endorsed by the Department of Defense or U.S. Army.
NR 56
TC 1
Z9 1
U1 2
U2 4
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD FEB
PY 2016
VL 181
IS 2
BP 173
EP 179
DI 10.7205/MILMED-D-15-00036
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA DI3ND
UT WOS:000373404500020
PM 26837087
ER
PT J
AU Kamapantula, BK
Mayo, ML
Perkins, EJ
Ghosh, P
AF Kamapantula, Bhanu K.
Mayo, Michael L.
Perkins, Edward J.
Ghosh, Preetam
TI The Structural Role of Feed-Forward Loop Motif in Transcriptional
Regulatory Networks
SO MOBILE NETWORKS & APPLICATIONS
LA English
DT Article; Proceedings Paper
CT 8th International Conference on Bio-Inspired Information and
Communications Technologies (BICT)
CY DEC 01-03, 2014
CL Boston, MA
DE Biological robustness; Transcriptional network; Feed-forward loop;
Signal transduction
ID ESCHERICHIA-COLI; COMPLEX NETWORKS
AB We present multiple approaches to identify the significance of topological metrics that contribute to biological network robustness. We examine and compare the communication efficiency of transcriptional networks extracted from the bacterium Escherichia coli and the baker's yeast Saccharomyces cerevisiae using discrete event simulation based in silico experiments. The packet receipt rate is used as a dynamical metric to understand information flow, while unsupervised machine learning techniques are used to examine underlying relationships inherent to the network topology. To this effect, we defined sixteen features based on structural/topological significance, such as transcriptional motifs, and other traditional metrics, such as network density and average shortest path, among others. Support vector classification is used with these features after parameters were identified using a cross-validation grid-search method. Feature ranking is performed using analysis of variance F-value metric. We found that feed-forward loop (FFL) based features consistently show up as significant in both the bacterial and yeast networks, even at different noise levels. We then use a supervised machine learning technique (random forests) to investigate the structural prominence of the FFL motif in information transmission using subnetworks (larger sample size compared to the unsupervised approach) extracted from Escherichia coli transcriptional regulatory network. Further, we study the role of FFLs in signal transduction within the complete Escherichia coli regulatory network. Although our work reveals a minimal role of FFLs in signal transduction, it highlights the structural role of FFLs in information transmission captured by random forest regression. This work paves the way to design specialized engineered systems, such as wireless sensor networks, that exploit topological properties of natural networks to attain maximum efficiency.
C1 [Kamapantula, Bhanu K.; Ghosh, Preetam] Virginia Commonwealth Univ, Richmond, VA USA.
[Mayo, Michael L.; Perkins, Edward J.] US Army, Engineer Res & Dev Ctr, Vicksburg, MS USA.
RP Ghosh, P (reprint author), Virginia Commonwealth Univ, Richmond, VA USA.
EM kamapantulbk@vcu.edu; Michael.L.Mayo@usace.army.mil;
Edward.J.Perkins@erdc.dren.mil; pghosh@vcu.edu
NR 21
TC 0
Z9 0
U1 1
U2 2
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1383-469X
EI 1572-8153
J9 MOBILE NETW APPL
JI Mobile Netw. Appl.
PD FEB
PY 2016
VL 21
IS 1
BP 191
EP 205
DI 10.1007/s11036-016-0708-6
PG 15
WC Computer Science, Hardware & Architecture; Computer Science, Information
Systems; Telecommunications
SC Computer Science; Telecommunications
GA DI7MA
UT WOS:000373683400016
ER
PT J
AU Gage, EA
Cooper, DJ
Bultema, B
McKernan, C
Lichvar, R
AF Gage, Edward A.
Cooper, David J.
Bultema, Betsy
McKernan, Cristina
Lichvar, Robert
TI Developing a Field-Tested Wetland Indicator Rating for Blue Spruce
(Picea Pungens) in the Southern Rocky Mountains
SO WETLANDS
LA English
DT Article
DE Wetland delineation; Hydrophyte; National Wetland Plant List;
Regulation; Picea pungens
ID NORTH-AMERICAN MONSOON; MODELS; PRECIPITATION; DISTRIBUTIONS;
ENGELMANNII; EXPLANATION; VARIABILITY; REGRESSION; COLORADO; MAXENT
AB To be identified as a wetland under U.S. Federal regulations, a site must, under normal circumstances, support vegetation dominated by hydrophytes. A list of hydrophytes and their wetland indicator rating is published by the U.S. Army Corps of Engineers as the National Wetland Plant List (NWPL) and is the basis for assessing the vegetation criteria of Federal wetland delineation manuals. Ratings are primarily based on expert opinion and few empirical studies have been done, particularly at landscape scales. In this study, we developed an approach for quantifying plant indicator ratings at broad spatial scales and used it to estimate the frequency that Picea pungens Engelm. (Colorado blue spruce) occurs in wetlands across a 22,921 km(2) study area in the southern Rocky Mountains. Species distribution models were developed and used to inform a multistage field sampling design. Wetland soil and hydrology indicators were assessed around 423 randomly selected trees in 22 HUC12 watersheds. Only 16.5 % of trees occurred in wetlands, suggesting that a rating of facultative upland (FACU) is more appropriate than the currently published rating of facultative (FAC) for our study area. This study demonstrates that it is feasible to quantitatively evaluate ratings for species even at broad landscape scales.
C1 [Gage, Edward A.; Cooper, David J.; Bultema, Betsy; McKernan, Cristina] Colorado State Univ, Dept Forest & Rangeland Stewardship, Ft Collins, CO 80523 USA.
[Lichvar, Robert] US Army Corps Engineers, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA.
RP Gage, EA (reprint author), Colorado State Univ, Dept Forest & Rangeland Stewardship, Ft Collins, CO 80523 USA.
EM edward.gage@colostate.edu
FU U.S. Environmental Protection Agency; U.S. Fish and Wildlife Service;
U.S. Army Corps of Engineers under the Wetland Regulatory Assistance
Program (WRAP)
FX Funding for this study was provided by the U.S. Environmental Protection
Agency, U.S. Fish and Wildlife Service, and the U.S. Army Corps of
Engineers under the Wetland Regulatory Assistance Program (WRAP).
Special thanks to Dr. Anthony Olson of EPA, Western Ecology Division,
for discussions related to our sampling design and methods. Thanks to
Joanna Harter, Sven Bultema, Dan Kotter, and Amanda Snyder for
assistance in the field and to Mary Butterwick for input on study
objectives and design. Thanks also to Catherine Jarnevich for help with
species distribution modeling.
NR 52
TC 0
Z9 0
U1 2
U2 4
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0277-5212
EI 1943-6246
J9 WETLANDS
JI Wetlands
PD FEB
PY 2016
VL 36
IS 1
BP 111
EP 120
DI 10.1007/s13157-015-0721-8
PG 10
WC Ecology; Environmental Sciences
SC Environmental Sciences & Ecology
GA DI6XR
UT WOS:000373644000010
ER
PT J
AU Islam, D
Lombardini, E
Ruamsap, N
Imerbsin, R
Khantapura, P
Teo, I
Neesanant, P
Gonwong, S
Yongvanitchit, K
Swierczewski, BE
Mason, CJ
Shaunak, S
AF Islam, Dilara
Lombardini, Eric
Ruamsap, Nattaya
Imerbsin, Rawiwan
Khantapura, Patchariya
Teo, Ian
Neesanant, Pimmnapar
Gonwong, Siriphan
Yongvanitchit, Kosol
Swierczewski, Brett E.
Mason, Carl J.
Shaunak, Sunil
TI Controlling the cytokine storm in severe bacterial diarrhoea with an
oral Toll-like receptor 4 antagonist
SO IMMUNOLOGY
LA English
DT Article
DE bacterial diarrhoea; cytokines; inflammation; Toll-like receptor-4
ID NORMAL RHESUS MACAQUES; SHIGELLA-FLEXNERI; T-CELLS; NECROTIZING
ENTEROCOLITIS; NONHUMAN-PRIMATES; INTERFERON-BETA; SHIGA TOXIN; GUT;
NEUTROPHILS; INDUCTION
AB Shigella dysenteriae causes the most severe of all infectious diarrhoeas and colitis. We infected rhesus macaques orally and also treated them orally with a small and non-absorbable polypropyletherimine dendrimer glucosamine that is a Toll-like receptor-4 (TLR4) antagonist. Antibiotics were not given for this life-threatening infection. Six days later, the clinical score for diarrhoea, mucus and blood was 54% lower, colon interleukin-8 and interleukin-6 were both 77% lower, and colon neutrophil infiltration was 75% less. Strikingly, vasculitis did not occur and tissue fibrin thrombi were reduced by 67%. There was no clinical toxicity or adverse effect of dendrimer glucosamine on systemic immunity. This is the first report in non-human primates of the therapeutic efficacy of a small and orally bioavailable TLR antagonist in severe infection. Our results show that an oral TLR4 antagonist can enable controlled resolution of the infection-related-inflammatory response and can also prevent neutrophil-mediated gut wall necrosis in severe infectious diarrhoeas.
C1 [Islam, Dilara; Ruamsap, Nattaya; Khantapura, Patchariya; Neesanant, Pimmnapar; Gonwong, Siriphan; Yongvanitchit, Kosol; Swierczewski, Brett E.; Mason, Carl J.] Armed Forces Res Inst Med Sci, Dept Enter Dis, Bangkok 10400, Thailand.
[Lombardini, Eric; Imerbsin, Rawiwan] Armed Forces Res Inst Med Sci, Dept Vet Med, Bangkok 10400, Thailand.
[Teo, Ian; Shaunak, Sunil] Univ London Imperial Coll Sci Technol & Med, Dept Med, Hammersmith Campus, London W12 0NN, England.
[Teo, Ian; Shaunak, Sunil] Univ London Imperial Coll Sci Technol & Med, Dept Infect Dis, Hammersmith Campus, London W12 0NN, England.
[Teo, Ian; Shaunak, Sunil] Univ London Imperial Coll Sci Technol & Med, Dept Immun, Hammersmith Campus, London W12 0NN, England.
[Shaunak, Sunil] Univ London Imperial Coll Sci Technol & Med, Dept Pathol, Hammersmith Campus, London W12 0NN, England.
[Shaunak, Sunil] Univ London Imperial Coll Sci Technol & Med, Dept Chem, Hammersmith Campus, London W12 0NN, England.
RP Shaunak, S (reprint author), Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Fac Med, Du Cane Rd, London W12 0NN, England.
EM s.shaunak@imperial.ac.uk
OI MASON, CARL/0000-0002-3676-2811
FU NIAID under Inter-Agency Agreement [Y1-AI-4906-03]; US Army Medical
Research & Materiel Command; Imperial Biomedical Research Centre;
Williams Trust
FX SS, DI, IT and CJM conceived and designed the study. RI was the vet and
EL was the pathologist. DI, NR, PK, PN, SG, and KY performed the animal
study and tissue analysis. The manuscript was written by SS, DI, EL, IT,
BES and CJM with input from all authors. We are grateful for the
technical support provided by Kesara Chumpolkulwong and Alongkorn
Hanrujirakomjorn for veterinary procedures, Amnat Andang, Rachata
Jecksaeng, Mana Saitasao and Siwakorn Sirisrisopa for husbandry, and
Paphavee Lertsethtakarn, Sathit Pichyangkul, Ajchar Aksomboon, Nuanpan
Khemnu, Kaewkanya Nakjarung and Sasikorn Silapong for assays. This study
was funded by NIAID under Inter-Agency Agreement Y1-AI-4906-03 and US
Army Medical Research & Materiel Command and Imperial Biomedical
Research Centre and Williams Trust grants to CJM, BES and SS.
NR 60
TC 1
Z9 1
U1 0
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0019-2805
EI 1365-2567
J9 IMMUNOLOGY
JI Immunology
PD FEB
PY 2016
VL 147
IS 2
BP 178
EP 189
DI 10.1111/imm.12549
PG 12
WC Immunology
SC Immunology
GA DH6TY
UT WOS:000372926100005
PM 26496144
ER
PT J
AU Bennett, JW
Yadava, A
Tosh, D
Sattabongkot, J
Komisar, J
Ware, LA
McCarthy, WF
Cowden, JJ
Regules, J
Spring, MD
Paolino, K
Hartzell, JD
Cummings, JF
Richie, TL
Lumsden, J
Kamau, E
Murphy, J
Lee, C
Parekh, F
Birkett, A
Cohen, J
Ballou, WR
Polhemus, ME
Vanloubbeeck, YF
Vekemans, J
Ockenhouse, CF
AF Bennett, Jason W.
Yadava, Anjali
Tosh, Donna
Sattabongkot, Jetsumon
Komisar, Jack
Ware, Lisa A.
McCarthy, William F.
Cowden, Jessica J.
Regules, Jason
Spring, Michele D.
Paolino, Kristopher
Hartzell, Joshua D.
Cummings, James F.
Richie, Thomas L.
Lumsden, Joanne
Kamau, Edwin
Murphy, Jittawadee
Lee, Cynthia
Parekh, Falgunee
Birkett, Ashley
Cohen, Joe
Ballou, W. Ripley
Polhemus, Mark E.
Vanloubbeeck, Yannick F.
Vekemans, Johan
Ockenhouse, Christian F.
TI Phase 1/2a Trial of Plasmodium vivax Malaria Vaccine Candidate
VMP001/AS01(B) in Malaria-Naive Adults: Safety, Immunogenicity, and
Efficacy
SO PLOS NEGLECTED TROPICAL DISEASES
LA English
DT Article
ID CIRCUMSPOROZOITE PROTEIN; SPOROZOITES; RTS,S/AS02A; VOLUNTEERS;
ANTIBODIES; PRIMAQUINE
AB Background
A vaccine to prevent infection and disease caused by Plasmodium vivax is needed both to reduce the morbidity caused by this parasite and as a key component in efforts to eradicate malaria worldwide. Vivax malaria protein 1 (VMP001), a novel chimeric protein that incorporates the amino-and carboxy-terminal regions of the circumsporozoite protein (CSP) and a truncated repeat region that contains repeat sequences from both the VK210 (type 1) and the VK247 (type 2) parasites, was developed as a vaccine candidate for global use.
Methods
We conducted a first-in-human Phase 1 dose escalation vaccine study with controlled human malaria infection (CHMI) of VMP001 formulated in the GSK Adjuvant System AS01(B). A total of 30 volunteers divided into 3 groups (10 per group) were given 3 intramuscular injections of 15 mu g, 30 mu g, or 60 mu g respectively of VMP001, all formulated in 500 mu L of AS01(B) at each immunization. All vaccinated volunteers participated in a P. vivax CHMI 14 days following the third immunization. Six non-vaccinated subjects served as infectivity controls.
Results
The vaccine was shown to be well tolerated and immunogenic. All volunteers generated robust humoral and cellular immune responses to the vaccine antigen. Vaccination did not induce sterile protection; however, a small but significant delay in time to parasitemia was seen in 59% of vaccinated subjects compared to the control group. An association was identified between levels of anti-type 1 repeat antibodies and prepatent period.
Significance
This trial was the first to assess the efficacy of a P. vivax CSP vaccine candidate by CHMI. The association of type 1 repeat-specific antibody responses with delay in the prepatency period suggests that augmenting the immune responses to this domain may improve strain-specific vaccine efficacy. The availability of a P. vivax CHMI model will accelerate the process of P. vivax vaccine development, allowing better selection of candidate vaccines for advancement to field trials.
C1 [Bennett, Jason W.; Yadava, Anjali; Tosh, Donna; Komisar, Jack; Ware, Lisa A.; Cowden, Jessica J.; Regules, Jason; Spring, Michele D.; Paolino, Kristopher; Cummings, James F.; Lumsden, Joanne; Kamau, Edwin; Murphy, Jittawadee; Polhemus, Mark E.; Ockenhouse, Christian F.] Walter Reed Army Inst Res, Malaria Vaccine Brach, Silver Spring, MD USA.
[Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
[McCarthy, William F.] US Army Med Mat Dev Act, Frederick, MD USA.
[Hartzell, Joshua D.] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA.
[Richie, Thomas L.] Naval Med Res Ctr, Silver Spring, MD USA.
[Lee, Cynthia; Parekh, Falgunee; Birkett, Ashley] PATH MVI, Washington, DC USA.
[Cohen, Joe; Ballou, W. Ripley; Vanloubbeeck, Yannick F.; Vekemans, Johan] GSK Vaccines, Rixensart, Belgium.
[Cohen, Joe] Cohen Biopharm Consulting, Brussels, Belgium.
RP Yadava, A (reprint author), Walter Reed Army Inst Res, Malaria Vaccine Brach, Silver Spring, MD USA.
EM Anjali.Yadava.Civ@mail.mil
FU Military Infectious Diseases Research Program, Maryland; PATH-MVI
FX This work was supported by intramural funding from the Military
Infectious Diseases Research Program, Maryland and PATH-MVI. The funders
had no role in study design, data collection and analysis, decision to
publish, or preparation of the manuscript.
NR 24
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U1 1
U2 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1935-2735
J9 PLOS NEGLECT TROP D
JI Plos Neglect. Trop. Dis.
PD FEB
PY 2016
VL 10
IS 2
AR e0004423
DI 10.1371/journal.pntd.0004423
PG 16
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA DH1TH
UT WOS:000372567300039
PM 26919472
ER
PT J
AU Alera, MT
Srikiatkhachorn, A
Velasco, JM
Tac-An, IA
Lago, CB
Clapham, HE
Fernandez, S
Levy, JW
Thaisomboonsuk, B
Klungthong, C
Macareo, LR
Nisalak, A
Hermann, L
Villa, D
Yoon, IK
AF Theresa Alera, Maria
Srikiatkhachorn, Anon
Mark Velasco, John
Tac-An, Ilya A.
Lago, Catherine B.
Clapham, Hannah E.
Fernandez, Stefan
Levy, Jens W.
Thaisomboonsuk, Butsaya
Klungthong, Chonticha
Macareo, Louis R.
Nisalak, Ananda
Hermann, Laura
Villa, Daisy
Yoon, In-Kyu
TI Incidence of Dengue Virus Infection in Adults and Children in a
Prospective Longitudinal Cohort in the Philippines
SO PLOS NEGLECTED TROPICAL DISEASES
LA English
DT Article
ID HEMORRHAGIC-FEVER; DISEASE; EPIDEMIOLOGY; THAILAND; TRANSMISSION;
INAPPARENT; FREQUENCY; INDONESIA; RISK
AB Background
The mean age of dengue has been increasing in some but not all countries. We sought to determine the incidence of dengue virus (DENV) infection in adults and children in a prospective cohort study in the Philippines where dengue is hyperendemic.
Methodology/Principal Findings
A prospective cohort of subjects >= 6 months old in Cebu City, Philippines, underwent active community-based surveillance for acute febrile illnesses by weekly contact. Fever history within the prior seven days was evaluated with an acute illness visit followed by 2, 5, and 8-day, and 3-week convalescent visits. Blood was collected at the acute and 3-week visits. Scheduled visits took place at enrolment and 12 months that included blood collections. Acute samples were tested by DENV PCR and acute/convalescent samples by DENV IgM/IgG ELISA to identify symptomatic infections. Enrolment and 12-month samples were tested by DENV hemagglutination inhibition (HAI)assay to identify subclinical infections. Of 1,008 enrolled subjects, 854 completed all study activities at 12 months per-protocol undergoing 868 person-years of surveillance. The incidence of symptomatic and subclinical infections was 1.62 and 7.03 per 100 person-years, respectively. However, in subjects > 15 years old, only one symptomatic infection occurred whereas 27 subclinical infections were identified. DENV HAI seroprevalence increased sharply with age with baseline multitypic HAIs associated with fewer symptomatic infections. Using a catalytic model, the historical infection rate among dengue naive individuals was estimated to be high at 11-22%/year.
Conclusions/Significance
In this hyperendemic area with high seroprevalence of multitypic DENV HAIs in adults, symptomatic dengue rarely occurred in individuals older than 15 years. Our findings demonstrate that dengue is primarily a pediatric disease in areas with high force of infection. However, the average age of dengue could increase if force of infection decreases over time, as is occurring in some hyperendemic countries such as Thailand.
C1 [Theresa Alera, Maria; Mark Velasco, John; Lago, Catherine B.] Philippines AFRIMS Virol Res Unit, CAP Bldg, Cebu, Philippines.
[Srikiatkhachorn, Anon] Univ Massachusetts, Sch Med, Dept Med, Div Infect Dis & Immunol, Worcester, MA USA.
[Tac-An, Ilya A.; Villa, Daisy] Cebu City Hlth Dept, Cebu, Philippines.
[Clapham, Hannah E.] Johns Hopkins Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
[Fernandez, Stefan; Levy, Jens W.; Thaisomboonsuk, Butsaya; Klungthong, Chonticha; Macareo, Louis R.; Nisalak, Ananda; Hermann, Laura; Yoon, In-Kyu] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand.
[Hermann, Laura] Univ Toronto, Dept Med, Toronto, ON, Canada.
[Yoon, In-Kyu] Int Vaccine Inst, Dengue Vaccine Initiat, Seoul, South Korea.
RP Alera, MT (reprint author), Philippines AFRIMS Virol Res Unit, CAP Bldg, Cebu, Philippines.
EM MariaTheresa.Alera.ca@afrims.org
FU Armed Forces Health Surveilance Center-Global Emerging Infections
Surveillance and Response System [P0140_14_AF]; Canadian Institutes of
Health Research Fellowship
FX This research was funded by a grant from the Armed Forces Health
Surveilance Center-Global Emerging Infections Surveillance and Response
System (Grant P0140_14_AF) and a Canadian Institutes of Health Research
Fellowship for LH. The funders had no role in study design, data
collection and analysis, decision to publish, or preparation of the
manuscript.
NR 29
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U1 1
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1935-2735
J9 PLOS NEGLECT TROP D
JI Plos Neglect. Trop. Dis.
PD FEB
PY 2016
VL 10
IS 2
AR e0004337
DI 10.1371/journal.pntd.0004337
PG 14
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA DH1TH
UT WOS:000372567300006
PM 26845762
ER
PT J
AU Warren, TK
Whitehouse, CA
Wells, J
Welch, L
Charleston, JS
Heald, A
Nichols, DK
Mattix, ME
Palacios, G
Kugleman, JR
Iversen, PL
Bavari, S
AF Warren, Travis K.
Whitehouse, Chris A.
Wells, Jay
Welch, Lisa
Charleston, Jay S.
Heald, Alison
Nichols, Donald K.
Mattix, Marc E.
Palacios, Gustavo
Kugleman, Jeffrey R.
Iversen, Patrick L.
Bavari, Sina
TI Delayed Time-to-Treatment of an Antisense Morpholino Oligomer Is
Effective against Lethal Marburg Virus Infection in Cynomolgus Macaques
SO PLOS NEGLECTED TROPICAL DISEASES
LA English
DT Article
ID EBOLA-VIRUS; HEMORRHAGIC-FEVER; NONHUMAN-PRIMATES; POSTEXPOSURE
PROTECTION; CELL-CULTURES; INHIBITION; MICE; PATHOGENESIS; AVI-7288;
EFFICACY
AB Marburg virus (MARV) is an Ebola-like virus in the family Filovirdae that causes sporadic outbreaks of severe hemorrhagic fever with a case fatality rate as high as 90%. AVI-7288, a positively charged antisense phosphorodiamidate morpholino oligomer (PMOplus) targeting the viral nucleoprotein gene, was evaluated as a potential therapeutic intervention for MARV infection following delayed treatment of 1, 24, 48, and 96 h post-infection (PI) in a nonhuman primate lethal challenge model. A total of 30 cynomolgus macaques were divided into 5 groups of 6 and infected with 1,830 plaque forming units of MARV subcutaneously. AVI-7288 was administered by bolus infusion daily for 14 days at 15 mg/kg body weight. Survival was the primary endpoint of the study. While none (0 of 6) of the saline group survived, 83-100% of infected monkeys survived when treatment was initiated 1, 24, 48, or 96 h post-infection (PI). The antisense treatment also reduced serum viremia and inflammatory cytokines in all treatment groups compared to vehicle controls. The antibody immune response to virus was preserved and tissue viral antigen was cleared in AVI-7288 treated animals. These data show that AVI-7288 protects NHPs against an otherwise lethal MARV infection when treatment is initiated up to 96 h PI.
C1 [Warren, Travis K.; Whitehouse, Chris A.; Wells, Jay; Welch, Lisa; Bavari, Sina] US Army, Med Res Inst Infect Dis, Mol & Translat Sci Div, Frederick, MD USA.
[Charleston, Jay S.; Heald, Alison; Iversen, Patrick L.] Sarepta Therapeut Inc, Cambridge, MA USA.
[Nichols, Donald K.; Mattix, Marc E.] US Army, Med Res Inst Infect Dis, Div Pathol, Frederick, MD USA.
[Palacios, Gustavo; Kugleman, Jeffrey R.] US Army, Med Res Inst Infect Dis, Ctr Genome Sci, Frederick, MD USA.
[Mattix, Marc E.] WIL Res, Ashland, OH USA.
RP Bavari, S (reprint author), US Army, Med Res Inst Infect Dis, Mol & Translat Sci Div, Frederick, MD USA.
EM sina.bavari.civ@mail.mil
OI Palacios, Gustavo/0000-0001-5062-1938
FU Joint Product Management Office of BioDefense Therapeutics (BDTx)
[W9113M-10-C-0056]
FX This work was conducted under a contract (W9113M-10-C-0056) with the
Joint Product Management Office of BioDefense Therapeutics (BDTx). BD-Tx
is a component of the Medical Countermeasure Systems Joint Project
Management Office (JPM-MCS) within the U.S. Department of Defense's
Joint Program Executive Office for Chemical and Biological Defense. The
funders had no role in study design, data collection and analysis,
decision to publish, or preparation of the manuscript.
NR 32
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U1 2
U2 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1935-2735
J9 PLOS NEGLECT TROP D
JI Plos Neglect. Trop. Dis.
PD FEB
PY 2016
VL 10
IS 2
AR e0004456
DI 10.1371/journal.pntd.0004456
PG 18
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA DH1TH
UT WOS:000372567300061
PM 26901785
ER
PT J
AU Lim, RB
AF Lim, Robert B.
TI Comment on: Rhabdomyolysis after bariatric surgery: a multicenter,
prospective study on incidence, risk factors, and therapeutic strategy
in a cohort from South-Italy
SO SURGERY FOR OBESITY AND RELATED DISEASES
LA English
DT Editorial Material
C1 [Lim, Robert B.] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA.
RP Lim, RB (reprint author), Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1550-7289
EI 1878-7533
J9 SURG OBES RELAT DIS
JI Surg. Obes. Relat. Dis.
PD FEB
PY 2016
VL 12
IS 2
BP 390
EP 391
PG 2
WC Surgery
SC Surgery
GA DH3FL
UT WOS:000372672800032
PM 26968502
ER
PT J
AU Cornell, R
Wrobel, E
Anderson, PE
AF Cornell, Rodger
Wrobel, Erik
Anderson, Paul E.
TI Research and Development of High-performance Explosives
SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
LA English
DT Article
DE Engineering; Issue 108; Explosives; Detonation; Testing; Fiber-optic;
Photo Doppler Velocimetry
ID ALUMINUM; DETONATION
AB Developmental testing of high explosives for military applications involves small-scale formulation, safety testing, and finally detonation performance tests to verify theoretical calculations. small-scale For newly developed formulations, the process begins with small-scale mixes, thermal testing, and impact and friction sensitivity. Only then do subsequent larger scale formulations proceed to detonation testing, which will be covered in this paper. Recent advances in characterization techniques have led to unparalleled precision in the characterization of early-time evolution of detonations. The new technique of photo-Doppler velocimetry (PDV) for the measurement of detonation pressure and velocity will be shared and compared with traditional fiber-optic detonation velocity and plate-dent calculation of detonation pressure. In particular, the role of aluminum in explosive formulations will be discussed. Recent developments led to the development of explosive formulations that result in reaction of aluminum very early in the detonation product expansion. This enhanced reaction leads to changes in the detonation velocity and pressure due to reaction of the aluminum with oxygen in the expanding gas products.
C1 [Cornell, Rodger; Wrobel, Erik] US Army ARDEC, Detonat Phys Branch, Picatinny Arsenal, Wharton, NJ USA.
[Anderson, Paul E.] US Army ARDEC, Explos Res Branch, Picatinny Arsenal, Wharton, NJ USA.
RP Anderson, PE (reprint author), US Army ARDEC, Explos Res Branch, Picatinny Arsenal, Wharton, NJ USA.
EM paul.e.anderson64.civ@mail.mil
FU Future Requirement of Enhanced Energetics for Decisive Munitions
(FREEDM) Program
FX The authors would like to thank the Future Requirement of Enhanced
Energetics for Decisive Munitions (FREEDM) Program for funding, Mike
VanDeWaal and Gerard Gillen for their assistance in testing, Paula Cook
for formulations assistance, and Ralph Acevedo and Brian Travers for
pressing of the samples.
NR 10
TC 0
Z9 0
U1 1
U2 3
PU JOURNAL OF VISUALIZED EXPERIMENTS
PI CAMBRIDGE
PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA
SN 1940-087X
J9 JOVE-J VIS EXP
JI J. Vis. Exp.
PD FEB
PY 2016
IS 108
AR e52950
DI 10.3791/52950
PG 12
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DH0WF
UT WOS:000372504100003
ER
PT J
AU Robinson, RM
Kothera, CS
Sanner, RM
Wereley, NM
AF Robinson, Ryan M.
Kothera, Curt S.
Sanner, Robert M.
Wereley, Norman M.
TI Nonlinear Control of Robotic Manipulators Driven by Pneumatic Artificial
Muscles
SO IEEE-ASME TRANSACTIONS ON MECHATRONICS
LA English
DT Article
DE Adaptive control; manipulator control; McKibben actuator; neural network
control; pneumatic artificial muscle (PAM); robotic manipulator; sliding
mode control
ID SLIDING-MODE CONTROL; ADAPTIVE-CONTROL; ACTUATORS
AB Lightweight, compliant actuators are particularly desirable in safety-conscious robotic systems intended for interaction with humans. Pneumatic artificial muscles (PAMs) exhibit these characteristics and are capable of higher specific work than comparably sized hydraulic actuators and electric motors. However, control of PAM-actuated systems has proven difficult due to the highly nonlinear nature of the actuators and the pneumatic systems driving their actuation. This study develops and investigates the performance of three advanced control strategies-sliding mode control, adaptive sliding mode control, and adaptive neural network (ANN) control-each containing a distinct level of a priori model knowledge, to enable smooth and accurate motion tracking of a single degree-of-freedom PAM-actuated manipulator. Originally developed by J.-J. Slotine and R.M. Sanner, the specific controllers employed in this study are significantly modified for application to pneumatically actuated open-chain manipulators with complex nonlinear dynamics. The two adaptive controllers are updated online and require no pretraining step. Several experiments are performed with each controller to evaluate and compare closed-loop tracking performance. Results highlight the dependence of a preferred control strategy on the level of model completeness and quality, and suggest that in most PAM-actuated manipulator scenarios, the ANN controller is preferable because it does not require a model of the pneumatic system or joint mechanism design, which can be difficult and time consuming to characterize, and is robust to changes in PAM actuator characteristics (due to fatigue or replacement).
C1 [Robinson, Ryan M.] Army Res Lab, Adelphi, MD 20783 USA.
[Kothera, Curt S.] InnoVital Syst Inc, Beltsville, MD 20705 USA.
[Sanner, Robert M.; Wereley, Norman M.] Univ Maryland, Dept Aerosp Engn, College Pk, MD 20742 USA.
RP Robinson, RM (reprint author), Army Res Lab, Adelphi, MD 20783 USA.; Kothera, CS (reprint author), InnoVital Syst Inc, Beltsville, MD 20705 USA.; Sanner, RM; Wereley, NM (reprint author), Univ Maryland, Dept Aerosp Engn, College Pk, MD 20742 USA.
EM ryan.robinson14.ctr@mail.mil; curt@innovitalsystems.com;
rmsanner@umd.edu; wereley@umd.edu
OI Wereley, Norman M. /0000-0002-9932-6988
FU L-3 Communications Fellowship
FX This work was supported in part by the L-3 Communications Fellowship
awarded to R. M. Robinson at the University of Maryland.
NR 32
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Z9 2
U1 10
U2 22
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1083-4435
EI 1941-014X
J9 IEEE-ASME T MECH
JI IEEE-ASME Trans. Mechatron.
PD FEB
PY 2016
VL 21
IS 1
BP 55
EP 68
DI 10.1109/TMECH.2015.2483520
PG 14
WC Automation & Control Systems; Engineering, Manufacturing; Engineering,
Electrical & Electronic; Engineering, Mechanical
SC Automation & Control Systems; Engineering
GA DG4BC
UT WOS:000372013900008
ER
PT J
AU Gasier, HG
Young, CR
Gaffney-Stomberg, E
McAdams, DC
Lutz, LJ
McClung, JP
AF Gasier, Heath G.
Young, Colin R.
Gaffney-Stomberg, Erin
McAdams, Douglas C.
Lutz, Laura J.
McClung, James P.
TI Cardiometabolic Health in Submariners Returning from a 3-Month Patrol
SO NUTRIENTS
LA English
DT Article
DE adipokines; chemokines; diet; inflammation; insulin resistance;
metabolic syndrome; physical activity; obesity
ID METABOLIC SYNDROME; INSULIN-RESISTANCE; WEIGHT REGAIN; RISK-FACTORS;
MASS INDEX; SHIFT WORK; OBESITY; DISEASE; LEPTIN; FAT
AB Confined space, limited exercise equipment, rotating shift work and reduced sleep may affect cardiometabolic health in submariners. To test this hypothesis, 53 male U.S. Submariners (20-39 years) were studied before and after a 3-month routine submarine patrol. Measures included anthropometrics, dietary and physical activity, biomarkers of cardiometabolic health, energy and appetite regulation, and inflammation. Before deployment, 62% of submariners had a body fat % (BF%) 25% (obesity), and of this group, 30% met the criteria for metabolic syndrome. In obese volunteers, insulin, the homeostatic model assessment of insulin resistance (HOMA-IR), leptin, the leptin/adiponectin ratio, and pro-inflammatory chemokines growth-related oncogene and macrophage-derived chemokine were significantly higher compared to non-obese submariners. Following the patrol, a significant mean reduction in body mass (5%) and fat-mass (11%) occurred in the obese group as a result of reduced energy intake (similar to 2000 kJ) during the patrol; and, independent of group, modest improvements in serum lipids and a mean reduction in interferon -induced protein 10 and monocyte chemotactic protein 1 were observed. Since 43% of the submariners remained obese, and 18% continued to meet the criteria for metabolic syndrome following the patrol, the magnitude of weight loss was insufficient to completely abolish metabolic dysfunction. Submergence up to 3-months, however, does not appear to be the cause of obesity, which is similar to that of the general population.
C1 [Gasier, Heath G.] Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, Bethesda, MD 20814 USA.
[Young, Colin R.] Naval Submarine Med Res Lab, Groton, CT 06349 USA.
[Gaffney-Stomberg, Erin; Lutz, Laura J.; McClung, James P.] US Army, Environm Med Res Inst, Natick, MA 01760 USA.
[McAdams, Douglas C.] Submarine Grp Nine, Silverdale, WA 98315 USA.
RP Gasier, HG (reprint author), Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, Bethesda, MD 20814 USA.
EM heath.gasier@usuhs.edu; colin.r.young.mil@mail.mil;
erin.g.stomberg.civ@mail.mil; douglas.c.mcadams.mil@mail.mil;
laura.j.lutz2.civ@mail.mil; james.p.mcclung8.civ@mail.mil
OI Young, Colin/0000-0002-4786-5840
FU Office of Naval Research; Warfighter Performance Department [34,
N0001411WX20143]; US Army Medical Research and Materiel Command
FX We would like to extend our gratitude to the USS Nevada Gold Crew
(SSBN733) for their participation in this study. In addition, we would
like to thank the Commander of Submarine Force, the Commanding Officers
of Submarine Group 9, and Submarine Squadron 17, and the Officer in
Charge of Naval Branch Health Clinic, Bangor, WA for their permission to
conduct this investigation. We would also like to thank David Fothergill
and Andrew Young for their assistance in improving the quality of this
manuscript, and to Lee Margolis, Nancy Murphy, David Gonzalez, Reginald
Clyburn, Glen Rossman, Darrin Way, Shawn Soutiere and Jennifer Rood for
their technical assistance. This work was supported by the Office of
Naval Research, Warfighter Performance Department (Code 34), award
number N0001411WX20143 and the US Army Medical Research and Materiel
Command.
NR 47
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Z9 2
U1 1
U2 2
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD FEB
PY 2016
VL 8
IS 2
AR 85
DI 10.3390/nu8020085
PG 12
WC Nutrition & Dietetics
SC Nutrition & Dietetics
GA DG1KT
UT WOS:000371827600010
PM 26867201
ER
PT J
AU Corron, NJ
Cooper, RM
Blakely, JN
AF Corron, Ned J.
Cooper, Roy M.
Blakely, Jonathan N.
TI Analytically solvable chaotic oscillator based on a first-order filter
SO CHAOS
LA English
DT Article
AB A chaotic hybrid dynamical system is introduced and its analytic solution is derived. The system is described as an unstable first order filter subject to occasional switching of a set point according to a feedback rule. The system qualitatively differs from other recently studied solvable chaotic hybrid systems in that the timing of the switching is regulated by an external clock. The chaotic analytic solution is an optimal waveform for communications in noise when a resistor-capacitor-integrate-and-dump filter is used as a receiver. As such, these results provide evidence in support of a recent conjecture that the optimal communication waveform for any stable infinite-impulse response filter is chaotic.
C1 [Corron, Ned J.; Cooper, Roy M.; Blakely, Jonathan N.] US Army RDECOM, Charles M Bowden Lab, Aviat & Missile Res, Ctr Dev & Engn, Redstone Arsenal, AL 35898 USA.
RP Corron, NJ (reprint author), US Army RDECOM, Charles M Bowden Lab, Aviat & Missile Res, Ctr Dev & Engn, Redstone Arsenal, AL 35898 USA.
NR 23
TC 3
Z9 3
U1 1
U2 1
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 1054-1500
EI 1089-7682
J9 CHAOS
JI Chaos
PD FEB
PY 2016
VL 26
IS 2
AR 023104
DI 10.1063/1.4941376
PG 6
WC Mathematics, Applied; Physics, Mathematical
SC Mathematics; Physics
GA DF8ID
UT WOS:000371600200004
PM 26931585
ER
PT J
AU Bennett, S
Pess, G
Bouwes, N
Roni, P
Bilby, RE
Gallagher, S
Ruzycki, J
Buehrens, T
Krueger, K
Ehinger, W
Anderson, J
Jordan, C
Bowersox, B
Greene, C
AF Bennett, Stephen
Pess, George
Bouwes, Nicolaas
Roni, Phil
Bilby, Robert E.
Gallagher, Sean
Ruzycki, Jim
Buehrens, Thomas
Krueger, Kirk
Ehinger, William
Anderson, Joseph
Jordan, Chris
Bowersox, Brett
Greene, Correigh
TI Progress and Challenges of Testing the Effectiveness of Stream
Restoration in the Pacific Northwest Using Intensively Monitored
Watersheds
SO FISHERIES
LA English
DT Article
ID HABITAT RESTORATION; RIVER RESTORATION; STATISTICAL POWER; COASTAL
STREAM; ECOSYSTEM; COLUMBIA; SALMON; MANAGEMENT; STEELHEAD; ABUNDANCE
AB Across the Pacific Northwest, at least 17 intensively monitored watershed projects have been implemented to test the effectiveness of a broad range of stream restoration actions for increasing the freshwater production of salmon and steelhead and to better understand fish-habitat relationships. We assess the scope and status of these projects and report on challenges implementing them. We suggest that all intensively monitored watersheds should contain key elements based on sound experimental design concepts and be implemented within an adaptive management framework to maximize learning. The most significant challenges reported by groups were (1) improving coordination between funders, restoration groups, and researchers so that restoration and monitoring actions occur based on the project design and (2) maintaining consistent funding to conduct annual monitoring and evaluation of data. However, we conclude that despite these challenges, the intensively monitored watershed approach is the most reliable means of assessing the efficacy of watershed-scale restoration.
C1 [Bennett, Stephen] Utah State Univ, Watershed Sci Dept, 5210 Old Main Hill, Logan, UT 84321 USA.
[Pess, George; Jordan, Chris] NOAA, Natl Marine Fisheries Serv, NW Fisheries Sci Ctr, Seattle, WA 98112 USA.
[Bouwes, Nicolaas] Eco Log Res Inc, Providence, UT USA.
[Roni, Phil] Cramer Fish Sci, Sammamish, WA USA.
[Bilby, Robert E.] Weyerhaeuser Co, Federal Way, WA USA.
[Gallagher, Sean] Calif Dept Fish & Wildlife, Ft Bragg, CA USA.
[Ruzycki, Jim] Oregon Dept Fish & Wildlife, La Grande, OR USA.
[Buehrens, Thomas] Washington Dept Fish & Wildlife, Vancouver, WA USA.
[Krueger, Kirk; Anderson, Joseph] Washington Dept Fish & Wildlife, Olympia, WA USA.
[Ehinger, William] Washington Dept Ecol, Lacey, WA USA.
[Bowersox, Brett] Idaho Dept Fish & Game, Lewiston, ID USA.
[Greene, Correigh] NOAA, Fisheries Northwest Fisheries Sci Ctr, Seattle, WA USA.
RP Bennett, S (reprint author), Utah State Univ, Watershed Sci Dept, 5210 Old Main Hill, Logan, UT 84321 USA.
EM bennett.ecological@gmail.com
FU National Oceanic and Atmospheric Administration; Integrated Status and
Effectiveness Monitoring Program - Bonneville Power Administration
Environment Fish and Wildlife [2003-017]; Washington Recreation and
Conservation Office; Oregon Watershed Enhancement Board; California
Fisheries Restoration Grant Program; Salmon Recovery Funding Board
FX We thank Jennifer Bayer and the Pacific Northwest Aquatic Monitoring
Partnership for hosting the intensively monitored watershed meeting and
providing support for gathering and summarizing the findings. Rebecca
Scully provided assistance in coordinating the IMW working group and
collating all the online supplements. Martha Jensen updated the IMW
location map. Sponsors of IMWs include the National Oceanic and
Atmospheric Administration, Integrated Status and Effectiveness
Monitoring Program - Bonneville Power Administration Environment Fish
and Wildlife (Project #2003-017), Washington Recreation and Conservation
Office, Oregon Watershed Enhancement Board, California Fisheries
Restoration Grant Program, and Salmon Recovery Funding Board.
NR 47
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Z9 5
U1 11
U2 27
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0363-2415
EI 1548-8446
J9 FISHERIES
JI Fisheries
PD FEB 1
PY 2016
VL 41
IS 2
BP 92
EP 103
DI 10.1080/03632415.2015.1127805
PG 12
WC Fisheries
SC Fisheries
GA DF9FJ
UT WOS:000371666100002
ER
PT J
AU Ivany, CG
Hoge, CW
AF Ivany, Christopher G.
Hoge, Charles W.
TI Suicide Attempts in the US Army
SO JAMA PSYCHIATRY
LA English
DT Letter
C1 [Ivany, Christopher G.] Off Army Surgeon Gen, 7700 Arlington Blvd, Falls Church, VA 22042 USA.
[Hoge, Charles W.] Walter Reed Army Inst Res, Silver Spring, MD USA.
RP Ivany, CG (reprint author), Off Army Surgeon Gen, 7700 Arlington Blvd, Falls Church, VA 22042 USA.
EM christopher.g.ivany.mil@mail.mil
NR 2
TC 0
Z9 0
U1 1
U2 1
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-622X
EI 2168-6238
J9 JAMA PSYCHIAT
JI JAMA Psychiatry
PD FEB
PY 2016
VL 73
IS 2
BP 176
EP 176
DI 10.1001/jamapsychiatry.2015.2363
PG 1
WC Psychiatry
SC Psychiatry
GA DF8MS
UT WOS:000371612500015
PM 26720633
ER
PT J
AU Coburn, JM
Chong, ST
Kim, HC
Chang, NW
Calix, LC
Resto, K
Lee, DJ
Johnson, JL
Robbins, RG
Klein, TA
AF Coburn, Jordan M.
Chong, Sung-Tae
Kim, Heung-Chul
Chang, Nicholas W.
Calix, Lesly C.
Resto, Karina
Lee, Dong-Jin
Johnson, Jaree L.
Robbins, Richard G.
Klein, Terry A.
TI Tick surveillance in four southwestern provinces of the Republic of
Korea during 2013
SO SYSTEMATIC AND APPLIED ACAROLOGY
LA English
DT Article
DE Haemaphysalis flava; Haemaphysalis longicornis; Ixodes nipponensis; tick
surveillance; Korea
ID SPOTTED-FEVER GROUP; THROMBOCYTOPENIA SYNDROME VIRUS;
HAEMAPHYSALIS-LONGICORNIS TICKS; BORNE ENCEPHALITIS-VIRUS; SOUTH-KOREA;
AMBLYOMMA-TESTUDINARIUM; RICKETTSIA-MONACENSIS; EHRLICHIA-CHAFFEENSIS;
MOLECULAR-DETECTION; IXODOIDEA-IXODIDAE
AB Tick-borne disease surveillance was conducted monthly at different sites in four southwestern provinces of the Republic of Korea (ROK) from April-October 2013. Three general habitats were surveyed: grasses (grasses and herbaceous and crawling vegetation), forests (pine, larch, deciduous, and mixed), and forests+grasses. A total of 27,029 ticks (1,534 adults; 11,755 nymphs; 13,740 larvae) belonging to three genera and five species were collected. Haemaphysalis longicornis (64.76%; 17,504) was the most commonly collected tick, followed by Haemaphysalis flava (29.22%; 7,899), Ixodes nipponensis (5.83%; 1,575), Amblyomma testudinarium (0.17%; 46), and Haemaphysalis phasiana (0.02%; 5). Overall, adult ticks accounted for only 5.68% of all ticks collected, while nymphs and larvae accounted for 43.49% and 50.83%, respectively. Haemaphysalis longicornis nymphs were commonly collected from April-June, followed by increased numbers of adults from June-August, and large numbers of larvae from August-September, while low numbers of all stages were collected during October. Haemaphysalis flava adults and nymphs were commonly collected from April-June and September-October, while large numbers of larvae were collected from July-August. Although fewer I. nipponensis were collected, seasonal developmental stage patterns followed those of H. flava. Similar proportions of males (47.96%) and females (52.04%) of H. flava were collected. However, the proportion of H. longicornis females (85.83%) collected was significantly higher than for males (14.17%), while the proportion of I. nipponensis males (57.62%) was significantly higher than for females (42.38%). Overall, the mean number of ticks collected/hour of collection was highest for forests+grasses (108.54), followed by grasses (97.28) and forests (66.64).
C1 [Coburn, Jordan M.; Chang, Nicholas W.; Klein, Terry A.] US Army Publ Hlth Command District Korea Provis, APO, AP 96205 USA.
[Coburn, Jordan M.; Chang, Nicholas W.; Klein, Terry A.] 65th Med Brigade, Force Hlth Protect & Prevent Med, Unit 15281, APO, AP 96205 USA.
[Chong, Sung-Tae; Kim, Heung-Chul; Johnson, Jaree L.] 65th Med Brigade, Multifunct Med Battal 168, Med Detachment 5, Unit 15247, APO, AP 96205 USA.
[Calix, Lesly C.; Johnson, Jaree L.] 65th Med Brigade, Force Hlth Protect & Prevent Med, Unit 15281, APO, AP 96205 USA.
[Resto, Karina] 65th Med Brigade, Multifunct Med Battal 168, Unit 15021, APO, AP 96205 USA.
[Lee, Dong-Jin] 65th Med Brigade, Multifunct Med Battal 168, Med Detachment 154, Unit 15515, APO, AP 96218 USA.
[Robbins, Richard G.] Armed Forces Pest Management Board, Off Assistant Secretary Def Energy Installat & En, Silver Spring, MD 20910 USA.
[Coburn, Jordan M.] Carl R Darnall Army Med Ctr, Dept Prevent Med, 76022 Crockett St, Ft Hood, TX 76544 USA.
[Chang, Nicholas W.] Madigan Army Med Ctr, Dept Prevent Med, 9911B East Johnson St, Jblm, WA 98327 USA.
[Calix, Lesly C.] ARS, Ctr Med Agr & Vet Entomol, 1600 SW 23rd Dr, Gainesville, FL 32608 USA.
[Resto, Karina] Joint Culinary Ctr Excellence JCCoE, 1831 Adams Ave,Bldg 4225, Ft Lee, VA 23801 USA.
[Lee, Dong-Jin] Korea Univ, Green Campus Bldg,Room 412,5 Ga, Seoul, South Korea.
RP Klein, TA (reprint author), 65th Med Brigade, Force Hlth Protect & Prevent Med, Unit 15281, APO, AP 96205 USA.
EM terry.a.klein2.civ@mail.mil
FU Armed Forces Health Surveillance Center-Global Emerging Infections
Surveillance and Response System (AFHSC-GEIS), Silver Spring, MD; 65th
Medical Brigade, Yongsan U.S. Army Garrison, Seoul, Korea; Public Health
Command Region-Pacific, Camp Zama, Japan
FX Funding for this work was provided by the Armed Forces Health
Surveillance Center-Global Emerging Infections Surveillance and Response
System (AFHSC-GEIS), Silver Spring, MD, the 65th Medical Brigade,
Yongsan U.S. Army Garrison, Seoul, Korea, and the Public Health Command
Region-Pacific, Camp Zama, Japan.
NR 54
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U1 0
U2 0
PU SYSTEMATIC & APPLIED ACAROLOGY SOC LONDON, NATURAL HISTORY MUSEUM
PI LONDON
PA DEPT ENTOMOLOGY, LONDON, SW7 5BD, ENGLAND
SN 1362-1971
J9 SYST APPL ACAROL-UK
JI Syst. Appl. Acarol.
PD FEB
PY 2016
VL 21
IS 2
BP 147
EP 165
PG 19
WC Entomology
SC Entomology
GA DF6XY
UT WOS:000371502700001
ER
PT J
AU Beske, PH
Bradford, AB
Grynovicki, JO
Glotfelty, EJ
Hoffman, KM
Hubbard, KS
Tuznik, KM
McNutt, PM
AF Beske, Phillip H.
Bradford, Aaron B.
Grynovicki, Justin O.
Glotfelty, Elliot J.
Hoffman, Katie M.
Hubbard, Kyle S.
Tuznik, Kaylie M.
McNutt, Patrick M.
TI Botulinum and Tetanus Neurotoxin-Induced Blockade of Synaptic
Transmission in Networked Cultures of Human and Rodent Neurons
SO TOXICOLOGICAL SCIENCES
LA English
DT Article
DE neurons; botulinum toxins; tetanus toxin; synaptic transmission;
electrophysiology; spontaneous postsynaptic currents
ID TOXIN TYPE-A; IN-VIVO; MOLECULAR-MECHANISMS; HIPPOCAMPAL-NEURONS;
CELL-CULTURE; STEM-CELLS; SYNAPSES; RELEASE; ASSAY; IDENTIFICATION
AB Clinical manifestations of tetanus and botulism result from an intricate series of interactions between clostridial neurotoxins (CNTs) and nerve terminal proteins that ultimately cause proteolytic cleavage of SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) proteins and functional blockade of neurotransmitter release. Although detection of cleaved SNARE proteins is routinely used as a molecular readout of CNT intoxication in cultured cells, impaired synaptic function is the pathophysiological basis of clinical disease. Work in our laboratory has suggested that the blockade of synaptic neurotransmission in networked neuron cultures offers a phenotypic readout of CNT intoxication that more closely replicates the functional endpoint of clinical disease. Here, we explore the value of measuring spontaneous neurotransmission frequencies as novel and functionally relevant readouts of CNT intoxication. The generalizability of this approach was confirmed in primary neuron cultures as well as human and mouse stem cell-derived neurons exposed to botulinumneurotoxin serotypes A-G and tetanus neurotoxin. The sensitivity and specificity of synaptic activity as a reporter of intoxication was evaluated in assays representing the principal clinical and research purposes of in vivo studies. Our findings confirm that synaptic activity offers a novel and functionally relevant readout for the in vitro characterizations of CNTs. They further suggest that the analysis of synaptic activity in neuronal cell cultures can serve as a surrogate for neuromuscular paralysis in the mouse lethal assay, and therefore is expected to significantly reduce the need for terminal animal use in toxin studies and facilitate identification of candidate therapeutics in cell-based screening assays.
C1 [Beske, Phillip H.; Bradford, Aaron B.; Grynovicki, Justin O.; Glotfelty, Elliot J.; Hoffman, Katie M.; Hubbard, Kyle S.; Tuznik, Kaylie M.; McNutt, Patrick M.] US Army, Med Res Inst Chem Def, Div Res, Cellular & Mol Biol Branch, Aberdeen Proving Ground, MD USA.
RP McNutt, PM (reprint author), US Army, Med Res Inst Chem Def, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA.
EM patrick.m.mcnutt2.civ@mail.mil
FU Defense Threat Reduction Agency - Joint Science and Technology Office,
Medical ST Division [CBM.THRTOX.01.10.RC.021]; National Institute of
Allergy and Infectious Diseases [IAA AOD12058-0001-0000, R01
5R01AI093504]; Defense Threat Reduction Agency-National Research
Council; National Research Council; Oak Ridge Institute of Science and
Engineering
FX This work was conducted under funding from the Defense Threat Reduction
Agency - Joint Science and Technology Office, Medical S&T Division
(grant number CBM.THRTOX.01.10.RC.021); National Institute of Allergy
and Infectious Diseases (IAA AOD12058-0001-0000 and R01 5R01AI093504).
This research was performed while P.B. held a Defense Threat Reduction
Agency-National Research Council Research Associateship award; K.H. held
a National Research Council Research Associateship award; and J.O.,
A.B., E.G., K.M., and K.T. held Oak Ridge Institute of Science and
Engineering Fellowship awards.
NR 53
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Z9 3
U1 2
U2 6
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
EI 1096-0929
J9 TOXICOL SCI
JI Toxicol. Sci.
PD FEB
PY 2016
VL 149
IS 2
BP 503
EP 515
DI 10.1093/toxsci/kfv254
PG 13
WC Toxicology
SC Toxicology
GA DF8NF
UT WOS:000371613900023
PM 26615023
ER
PT J
AU Alam, R
Labine, M
Karwacki, CJ
Kamat, PV
AF Alam, Rabeka
Labine, Molly
Karwacki, Christopher J.
Kamat, Prashant V.
TI Modulation of Cu2-xS Nanocrystal Plasmon Resonance through Reversible
Photoinduced Electron Transfer
SO ACS NANO
LA English
DT Article
DE plasmon resonance; copper sulfide; semiconductor nanocrystals; electron
transfer; methyl viologen
ID COPPER SULFIDE NANOCRYSTALS; SEMICONDUCTOR NANOCRYSTALS; SELENIDE
NANOCRYSTALS; PHOTOTHERMAL THERAPY; QUANTUM DOTS; SIZE; SHAPE;
NANOPARTICLES; RELAXATION; DYNAMICS
AB Copper sulfide (Cu2-xS) nanocrystals with nonstoichiometric composition exhibit plasmon resonance in the near -infrared region. Compositional changes and varying electron density markedly affect the position and intensity of the plasmon resonance. We report a photo chemically induced" phenomenon of modulating the plasmon resonance in a controlled fashion. As photo generated reduced methyl viologen radicals transfer electrons to Cu2-xS in inert solutions, " we observe a decrease in localized surface plasmon resonance (LSPR) absorbance at 1160 nm. Upon exposure to air, the plasmon resonance band recovers as stored electrons are scavenged away by oxygen. This cycle of electron charge and discharge of Cu2-xS nanocrystals is reversible and can be repeated through photoirradiation in N-2 saturated solution followed by exposure of the suspension to air. The spectroscopic studies that provide mechanistic insights into the reversible charging and discharging of plasmonic Cu2-xS are discussed.
C1 [Alam, Rabeka; Labine, Molly; Kamat, Prashant V.] Univ Notre Dame, Radiat Lab, Notre Dame, IN 46556 USA.
[Alam, Rabeka; Labine, Molly; Kamat, Prashant V.] Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA.
[Karwacki, Christopher J.] US Army, Edgewood Chem Biol Ctr, Res Dev & Engn Command, 5183 Blackhawk Rd, Aberdeen, MD 21010 USA.
[Labine, Molly] Univ Guelph, Guelph, ON N1G 2W1, Canada.
RP Kamat, PV (reprint author), Univ Notre Dame, Radiat Lab, Notre Dame, IN 46556 USA.; Kamat, PV (reprint author), Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA.
EM pkamat@nd.edu
FU Sustainable Energy Initiative (SEI) funds MCF part of the Center for
Sustainable Energy at Notre Dame (ND Energy); ARO [64011-CH]; Division
of Chemical Sciences, Geosciences, and Biosciences, Office of Basic
Energy Sciences of the U.S. Department of Energy [DE-FC02-04ER15533]
FX We would like to acknowledge Steven Kobosko and Ian Lightcap for help
with XPS data collection and analysis. We thank the ND Energy Materials
Characterization Facility (MCF) for the use of the UV visible Near-IR
spectrometer, XPS, and TGA. The Sustainable Energy Initiative (SEI)
funds MCF, which is part of the Center for Sustainable Energy at Notre
Dame (ND Energy). We also thank Notre Dame Integrated Imaging Facility
(NDIIF) for electron microscopy facilities. P.V.K. and R.A. thank the
Army Research Office for the support through the award ARO 64011-CH.
P.V.K. and M.L. also acknowledge the support by the Division of Chemical
Sciences, Geosciences, and Biosciences, Office of Basic Energy Sciences
of the U.S. Department of Energy through award DE-FC02-04ER15533. This
is a document number 5099 from the Notre Dame Radiation Laboratory.
NR 38
TC 3
Z9 3
U1 23
U2 53
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1936-0851
EI 1936-086X
J9 ACS NANO
JI ACS Nano
PD FEB
PY 2016
VL 10
IS 2
BP 2880
EP 2886
DI 10.1021/acsnano.5b08066
PG 7
WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
Nanotechnology; Materials Science, Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA DE9VL
UT WOS:000370987400133
PM 26853633
ER
PT J
AU Wood, AW
Hopson, T
Newman, A
Brekke, L
Arnold, J
Clark, M
AF Wood, Andrew W.
Hopson, Tom
Newman, Andy
Brekke, Levi
Arnold, Jeff
Clark, Martyn
TI Quantifying Streamflow Forecast Skill Elasticity to Initial Condition
and Climate Prediction Skill
SO JOURNAL OF HYDROMETEOROLOGY
LA English
DT Article
ID SOIL-MOISTURE; UNITED-STATES; RIVER-BASIN; PREDICTABILITY; MODELS;
RUNOFF; ERRORS; SNOW
AB Water resources management decisions commonly depend on monthly to seasonal streamflow forecasts, among other kinds of information. The skill of such predictions derives from the ability to estimate a watershed's initial moisture and energy conditions and to forecast future weather and climate. These sources of predictability are investigated in an idealized (i.e., perfect model) experiment using calibrated hydrologic simulation models for 424 watersheds that span the continental United States. Prior work in this area also followed an ensemble-based strategy for attributing streamflow forecast uncertainty, but focused only on two end points representing zero and perfect information about future forcings and initial conditions. This study extends the prior approach to characterize the influence of varying levels of uncertainty in each area on streamflow prediction uncertainty. The sensitivities enable the calculation of flow forecast skill elasticities (i.e., derivatives) relative to skill in either predictability source, which are used to characterize the regional, seasonal, and predictand variations in flow forecast skill dependencies. The resulting analysis provides insights on the relative benefits of investments toward improving watershed monitoring (through modeling and measurement) versus improved climate forecasting. Among other key findings, the results suggest that climate forecast skill improvements can be amplified in streamflow prediction skill, which means that climate forecasts may have greater benefit for monthly-to-seasonal flow forecasting than is apparent from climate forecast skill considerations alone. The results also underscore the importance of advancing hydrologic modeling, expanding watershed observations, and leveraging data assimilation, all of which help capture initial hydrologic conditions that are often the dominant influence on hydrologic predictions.
C1 [Wood, Andrew W.; Hopson, Tom; Newman, Andy; Clark, Martyn] NCAR, Res Applicat Lab, POB 3000, Boulder, CO 80307 USA.
[Brekke, Levi] US Bur Reclamat, Off Res & Dev, Denver, CO 80225 USA.
[Arnold, Jeff] US Army, Corps Engineers, Inst Water Resources, Seattle, WA USA.
RP Wood, AW (reprint author), NCAR, Res Applicat Lab, POB 3000, Boulder, CO 80307 USA.
EM andywood@ucar.edu
FU Bureau of Reclamation; U.S. Army Corps of Engineers; National Science
Foundation
FX The research and analysis reported herein were supported by the Bureau
of Reclamation and the U.S. Army Corps of Engineers. We would like to
acknowledge high-performance computing support from Yellowstone
(ark:/85065/d7wd3xhc) provided by NCAR's Computational and Information
Systems Laboratory, sponsored by the National Science Foundation. We
also thank two anonymous reviewers for critical and constructive
comments that have substantially enhanced the clarity and readability of
the paper.
NR 40
TC 4
Z9 4
U1 3
U2 13
PU AMER METEOROLOGICAL SOC
PI BOSTON
PA 45 BEACON ST, BOSTON, MA 02108-3693 USA
SN 1525-755X
EI 1525-7541
J9 J HYDROMETEOROL
JI J. Hydrometeorol.
PD FEB
PY 2016
VL 17
IS 2
BP 651
EP 668
DI 10.1175/JHM-D-14-0213.1
PG 18
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA DF8NH
UT WOS:000371614100001
ER
PT J
AU Mondello, S
Xanthopoulos, P
Korenkevych, D
Czeiter, E
Tortella, F
Hayes, R
Barzo, P
Pardalos, P
Buki, A
AF Mondello, S.
Xanthopoulos, P.
Korenkevych, D.
Czeiter, E.
Tortella, F.
Hayes, R.
Barzo, P.
Pardalos, P.
Buki, A.
TI MULTIMODAL MONITORING AND OUTCOME PREDICTION AFTER TRAUMATIC BRAIN
INJURY USING SUPPORT VECTOR MACHINES
SO JOURNAL OF NEUROTRAUMA
LA English
DT Meeting Abstract
CT 12th Symposium of the International-Neurotrauma-Society
CY FEB 01-04, 2016
CL Cape Town, SOUTH AFRICA
SP Int Neurotrauma Soc
C1 [Mondello, S.] Univ Messina, I-98100 Messina, Italy.
[Xanthopoulos, P.; Korenkevych, D.; Pardalos, P.] Univ Florida, Gainesville, FL 32611 USA.
[Czeiter, E.; Buki, A.] Univ Pecs, Pecs, Hungary.
[Tortella, F.] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Hayes, R.] Banyan Biomarkers Inc, Alachua, FL USA.
[Barzo, P.] Univ Szeged, Szeged, Hungary.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD FEB 1
PY 2016
VL 33
IS 3
MA 78
BP A13
EP A14
PG 2
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA DC9AV
UT WOS:000369513600038
ER
PT J
AU Mondello, S
Shear, D
Bramlett, H
Dixon, C
Schmid, K
Dietrich, W
Wang, K
Hayes, R
Glushakova, O
Povlishock, J
Tortella, F
Kochanek, P
AF Mondello, S.
Shear, D.
Bramlett, H.
Dixon, C.
Schmid, K.
Dietrich, W.
Wang, K.
Hayes, R.
Glushakova, O.
Povlishock, J.
Tortella, F.
Kochanek, P.
TI THE POTENTIAL UTILITY OF BRAIN INJURY BIOMARKER IN PRE-CLINICAL DRUG
SCREENING BY OPERATION BRAIN TRAUMA THERAPY
SO JOURNAL OF NEUROTRAUMA
LA English
DT Meeting Abstract
CT 12th Symposium of the International-Neurotrauma-Society
CY FEB 01-04, 2016
CL Cape Town, SOUTH AFRICA
SP Int Neurotrauma Soc
C1 [Mondello, S.] Univ Messina, I-98100 Messina, Italy.
[Shear, D.; Schmid, K.; Tortella, F.] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Bramlett, H.] Univ Miami, Miller Sch Med, Coral Gables, FL 33124 USA.
[Dixon, C.; Kochanek, P.] Univ Pittsburgh, Pittsburgh, PA 15260 USA.
[Dietrich, W.] Univ Miami, Coral Gables, FL 33124 USA.
[Wang, K.] Univ Florida, Gainesville, FL 32611 USA.
[Hayes, R.; Glushakova, O.] Banyan Biomarkers Inc, Alachua, FL USA.
[Povlishock, J.] Virginia Commonwealth Univ, Richmond, VA 23284 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD FEB 1
PY 2016
VL 33
IS 3
MA 77
BP A13
EP A13
PG 1
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA DC9AV
UT WOS:000369513600037
ER
PT J
AU Zuber, S
AF Zuber, Stephan
TI High-energy Computed Tomographic Inspection of Munitions
SO MATERIALS EVALUATION
LA English
DT Article
DE radiography; high energy; computed tomography; munitions; nondestructive
testing; NDT; computed tomography
AB This is a technical overview showing the application of using advanced computed tomography for the inspection of munitions and weapons systems. Although computed tomography cannot produce full-rate production throughput, the quality assurance it can provide on research and development components, reverse engineering, and malfunction investigations is unmatched. Using computed tomography within the Department of Defense is highly beneficial to ensure the end products function correctly and are effective.
C1 [Zuber, Stephan] US Army, Armament Res Dev & Engn Ctr, ASNT NDT Level 3, Radiog Lab,Qual Engn & Syst Assurance Directorate, Picatinny Arsenal, NJ 07806 USA.
RP Zuber, S (reprint author), US Army, Armament Res Dev & Engn Ctr, ASNT NDT Level 3, Radiog Lab,Qual Engn & Syst Assurance Directorate, Picatinny Arsenal, NJ 07806 USA.
EM stephan.c.zuber.civ@mail.mil
NR 5
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC NONDESTRUCTIVE TEST
PI COLUMBUS
PA 1711 ARLINGATE LANE PO BOX 28518, COLUMBUS, OH 43228-0518 USA
SN 0025-5327
J9 MATER EVAL
JI Mater. Eval.
PD FEB
PY 2016
VL 74
IS 2
BP 194
EP 202
PG 9
WC Materials Science, Characterization & Testing
SC Materials Science
GA DD8WI
UT WOS:000370207200005
ER
PT J
AU Sun, J
Choi, KK
AF Sun, Jason
Choi, Kwong-Kit
TI Fabrication of resonator-quantum well infrared photodetector focal plane
array by inductively coupled plasma etching
SO OPTICAL ENGINEERING
LA English
DT Article
DE inductively coupled plasma etching; resonator-quantum well infrared
photodetectors; focal plane array; GaAs substrate; removal
ID GAAS; DAMAGE
AB Inductively coupled plasma (ICP) etching has distinct advantages over reactive ion etching in that the etching rates are considerably higher, the uniformity is much better, and the sidewalls of the etched material are highly anisotropic due to the higher plasma density and lower operating pressure. Therefore, ICP etching is a promising process for pattern transfer required during microelectronic and optoelectronic fabrication. Resonator-quantum well infrared photodetectors (R-QWIPs) are the next generation of QWIP detectors that use resonances to increase the quantum efficiency (QE). To fabricate R- QWIP focal plane arrays (FPAs), two optimized ICP etching processes are developed. Using these etching techniques, we have fabricated R- QWIP FPAs of several different formats and pixel sizes with the required dimensions and completely removed the substrates of the FPAs. Their QE spectra were tested to be 30 to 40%. The operability and spectral non-uniformity of the FPA is similar to 99.5 and 3%, respectively. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License
C1 [Sun, Jason; Choi, Kwong-Kit] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
RP Sun, J (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM jason.sun@arl.army.mil
NR 12
TC 0
Z9 0
U1 4
U2 13
PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA
SN 0091-3286
EI 1560-2303
J9 OPT ENG
JI Opt. Eng.
PD FEB
PY 2016
VL 55
IS 2
AR 026119
DI 10.1117/1.OE.55.2.026119
PG 5
WC Optics
SC Optics
GA DF3YD
UT WOS:000371283600042
ER
PT J
AU Lloyd, JT
Becker, R
AF Lloyd, J. T.
Becker, R.
TI Stress-based crystal analysis of yielding in rolled Mg AZ31B
SO PHILOSOPHICAL MAGAZINE
LA English
DT Article
DE micromechanics; Magnesium; twinning; crystal plasticity; yield surface;
polycrystal
ID MAGNESIUM ALLOY AZ31B; CRYSTALLOGRAPHIC TEXTURE; PURE MAGNESIUM;
MECHANICAL-BEHAVIOR; PLASTIC ANISOTROPY; DEFORMATION; EVOLUTION; STRAIN;
MODEL; METALS
AB A stress-based analysis is demonstrated that can be used to evaluate the effect of material orientation and loading conditions on the micro- and macro-scale yield response of strongly textured metals. This analysis is used to construct microscale yield surfaces for selected deformation mechanisms in rolled AZ31B. Two-dimensional projections of these surfaces are plotted along sample directions to quantify the relative activity of each mechanism for various loading conditions. By assigning each mechanism realistic strengths, the analysis is used to quantify the influence of each deformation mechanism on macroscale yield behaviour. Due to its simplicity, this analysis can be easily carried out to probe and visualize projections of material response in any part of stress space given the material's texture, its relevant deformation mechanisms and realistic initial strengths of these mechanisms.
C1 [Lloyd, J. T.; Becker, R.] US Army, Res Lab, RDRL WMP C, Impact Phys Branch, Aberdeen, MD USA.
RP Lloyd, JT (reprint author), US Army, Res Lab, RDRL WMP C, Impact Phys Branch, Aberdeen, MD USA.
EM jeffrey.t.lloyd.civ@mail.mil
NR 39
TC 2
Z9 2
U1 3
U2 7
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1478-6435
EI 1478-6443
J9 PHILOS MAG
JI Philos. Mag.
PD FEB 1
PY 2016
VL 96
IS 4
BP 370
EP 386
DI 10.1080/14786435.2015.1132854
PG 17
WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical
Engineering; Physics, Applied; Physics, Condensed Matter
SC Materials Science; Metallurgy & Metallurgical Engineering; Physics
GA DE5DJ
UT WOS:000370650900004
ER
PT J
AU Mueller, CJ
Cannella, WJ
Bays, JT
Bruno, TJ
DeFabio, K
Dettman, HD
Gieleciak, RM
Huber, ML
Kweon, CB
McConnell, SS
Pitz, WJ
Ratcliff, MA
AF Mueller, Charles J.
Cannella, William J.
Bays, J. Timothy
Bruno, Thomas J.
DeFabio, Kathy
Dettman, Heather D.
Gieleciak, Rafal M.
Huber, Marcia L.
Kweon, Chol-Bum
McConnell, Steven S.
Pitz, William J.
Ratcliff, Matthew A.
TI Diesel Surrogate Fuels for Engine Testing and Chemical-Kinetic Modeling:
Compositions and Properties
SO ENERGY & FUELS
LA English
DT Article
ID DISTILLATION CURVE APPROACH; THERMOPHYSICAL PROPERTIES; TRANSPORTATION
FUELS; CETANE NUMBER; N-HEXADECANE; SHOCK-TUBE; COMBUSTION; MECHANISM;
IGNITION; 1,3,5-TRIISOPROPYLCYCLOHEXANE
AB The primary objectives of this work were to formulate, blend, and characterize a set of four ultralow-sulfur diesel surrogate fuels in quantities sufficient to enable their study in single-cylinder-engine and combustion-vessel experiments. The surrogate fuels feature increasing levels of compositional accuracy (i.e., increasing exactness in matching hydrocarbon structural characteristics) relative to the single target diesel fuel upon which the surrogate fuels are based. This approach was taken to assist in determining the minimum level of surrogate-fuel compositional accuracy that is required to adequately emulate the performance characteristics of the target fuel under different combustion modes. For each of the four surrogate fuels, an approximately 30 L batch was blended, and a number of the physical aid chemical properties were measured. This work documents the surrogate-fuel creation process= and the results of the property measurements.
C1 [Mueller, Charles J.] Sandia Natl Labs, 7011 East Ave,MS 9053, Livermore, CA 94550 USA.
[Cannella, William J.; DeFabio, Kathy] Chevron Energy Technol Co, 100 Chevron Way, Richmond, CA 94801 USA.
[Bays, J. Timothy] Pacific NW Natl Lab, 902 Battelle Blvd, Richland, WA 99352 USA.
[Bruno, Thomas J.; Huber, Marcia L.] Natl Inst Stand & Technol, 325 Broadway, Boulder, CO 80305 USA.
[Dettman, Heather D.; Gieleciak, Rafal M.] Nat Resources Canada CanmetENERGY, 1 Oil Patch Dr, Devon, AB T9G 1A8, Canada.
[Kweon, Chol-Bum] US Army Res Lab, 4603 Flare Loop Rd, Aberdeen Proving Ground, MD 21005 USA.
[McConnell, Steven S.] Marathon Petr Co, 539 South Main St, Findlay, OH 45840 USA.
[Pitz, William J.] Lawrence Livermore Natl Lab, 7000 East Ave, Livermore, CA 94550 USA.
[Ratcliff, Matthew A.] Natl Renewable Energy Lab, 15013 Denver West Pkwy, Golden, CO 80401 USA.
RP Mueller, CJ (reprint author), Sandia Natl Labs, 7011 East Ave,MS 9053, Livermore, CA 94550 USA.
EM cjmuell@sandia.gov
RI Kweon, Chol-Bum/G-5425-2016
FU U.S. Department of Energy (U.S. DOE) Office of Vehicle Technologies;
Coordinating Research Council (CRC); CRC; Natural Resources Canada;
Canadian federal government interdepartmental Program of Energy Research
and Development (PERD); ecoENERGY Innovation Initiative (ecoEII); U.S.
Army Research Laboratory; U.S. Department of Energy [DE-AC04-94AL85000];
Chevron Energy Technology Co., a division of Chevron USA, Richmond, CA,
USA; U.S. DOE [DE-AC05-76RL01830, DE-AC52-07NA27344]; U.S. DOE, Vehicle
Technologies Office; Alliance for Sustainable Energy, LLC
[DE347AC36-99GO10337]
FX Funding for this research was provided by the U.S. Department of Energy
(U.S. DOE) Office of Vehicle Technologies, the Coordinating Research
Council (CRC) and the companies that employ the CRC members, Natural
Resources Canada and the Canadian federal government interdepartmental
Program of Energy Research and Development (PERD) and ecoENERGY
Innovation Initiative (ecoEII), and the U.S. Army Research Laboratory.
The study was conducted under the auspices of CRC. We thank U.S. DOE
program managers Kevin Stork and Gurpreet Singh for supporting the
participation of the U.S. national laboratories in this study. C.J.M's
portion of the research was conducted at the Combustion Research
Facility, Sandia National Laboratories, Livermore, CA, USA. Sandia is a
multiprogram laboratory operated by Sandia Corp., a Lockheed Martin
company, for the U.S. Department of Energy's National Nuclear Security
Administration under Contract DE-AC04-94AL85000. W.J.C's portion of the
research was funded by and conducted at Chevron Energy Technology Co., a
division of Chevron USA, Richmond, CA, USA. J.T.B's portion of the
research was conducted at Pacific Northwest National Laboratory, a
multiprogram laboratory operated by the Battelle Memorial Institute
under Contract No. DE-AC05-76RL01830 for the U.S. DOE. J.T.B. also
thanks Drs. John Linehan, Molly O'Hagan, and Suh-Jane Lee, Mr. Gregory
Coffey, Ms. Margaret Jones, Ms. Tricia Smurthwaite, and Ms. Diana Tran
for their discussions and assistance in obtaining data critical to this
work. W.J.P's portion of the research was performed under the auspices
of the U.S. DOE by Lawrence Livermore National Laboratory under Contract
DE-AC52-07NA27344. M.A.R's portion of the research was conducted at the
National Renewable Energy Laboratory, Golden, CO, USA, with support from
the U.S. DOE, Vehicle Technologies Office. NREL is operated by the
Alliance for Sustainable Energy, LLC under Contract No.
DE347AC36-99GO10337. M.A.R. thanks NREL colleagues Jon Luecke, Earl
Christensen, Gina Chupka, and Lisa Fouts for their excellent technical
contributions to this work. Finally, helpful input and guidance from
Kenneth D. Rose, formerly of ExxonMobil, are gratefully acknowledged.
NR 82
TC 12
Z9 12
U1 8
U2 22
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0887-0624
EI 1520-5029
J9 ENERG FUEL
JI Energy Fuels
PD FEB
PY 2016
VL 30
IS 2
BP 1445
EP 1461
DI 10.1021/acs.energyfuels.5b02879
PG 17
WC Energy & Fuels; Engineering, Chemical
SC Energy & Fuels; Engineering
GA DE5NZ
UT WOS:000370679000075
PM 27330248
ER
PT J
AU Maley, JM
AF Maley, James M.
TI Efficient Attitude Estimation for a Spin-Stabilized Projectile
SO JOURNAL OF GUIDANCE CONTROL AND DYNAMICS
LA English
DT Article
ID FLIGHT
AB An algorithm using an extended Kalman filter is presented for estimating the full attitude of a nose-controlled spin-stabilized projectile using magnetometers and a velocity vector estimate with increased computational efficiency. A dynamic model based on the projectile equations of motion is used in the predictor step of the Kalman filter. A new coordinate system is introduced that enables both the process and measurement models of the Kalman filter to be described by linear, slowly time-varying systems. This property is exploited to generate a steady-state Kalman filter which per current knowledge, has never been done for this problem. Both the extended Kalman filter and steady-state Kalman filter are shown to perform well in simulation studies, and the difference in performance between the two filters is very small.
C1 [Maley, James M.] US Army, Res Lab, Guidance Technol Branch, Aberdeen Proving Ground, MD 21005 USA.
RP Maley, JM (reprint author), US Army, Res Lab, Guidance Technol Branch, Aberdeen Proving Ground, MD 21005 USA.
FU Armament Research, Development, and Engineering Center
FX The author gratefully acknowledges the sponsorship of the Project
Manager for Combat Ammunition Systems and the technical contributions
(including providing the flight system simulation) of the Armament
Research, Development, and Engineering Center. The author also would
like to thank Luisa Fairfax and Frank Fresconi for their comments and
insight, as well as Frank Fresconi for providing a detailed technical
review of this document.
NR 14
TC 1
Z9 1
U1 2
U2 8
PU AMER INST AERONAUTICS ASTRONAUTICS
PI RESTON
PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA
SN 0731-5090
EI 1533-3884
J9 J GUID CONTROL DYNAM
JI J. Guid. Control Dyn.
PD FEB
PY 2016
VL 39
IS 2
BP 339
EP 350
DI 10.2514/1.G001104
PG 12
WC Engineering, Aerospace; Instruments & Instrumentation
SC Engineering; Instruments & Instrumentation
GA DE7ZR
UT WOS:000370856100011
ER
PT J
AU Bradford, JC
Lukos, JR
Ferris, DP
AF Bradford, J. Cortney
Lukos, Jamie R.
Ferris, Daniel P.
TI Electrocortical activity distinguishes between uphill and level walking
in humans
SO JOURNAL OF NEUROPHYSIOLOGY
LA English
DT Article
DE locomotion; EEG; mobile brain imaging; motor control; independent
component analysis
ID INDEPENDENT COMPONENT ANALYSIS; VISUALLY GUIDED LOCOMOTION; POSTERIOR
PARIETAL CORTEX; CENTRAL PATTERN GENERATOR; SOLEUS-H-REFLEX; TREADMILL
WALKING; SLOPED SURFACES; WORKING-MEMORY; MOTOR CORTEX; GAMMA-RANGE
AB The objective of this study was to determine if electrocortical activity is different between walking on an incline compared with level surface. Subjects walked on a treadmill at 0% and 15% grades for 30 min while we recorded electroencephalography (EEG). We used independent component (IC) analysis to parse EEG signals into maximally independent sources and then computed dipole estimations for each IC. We clustered cortical source ICs and analyzed event-related spectral perturbations synchronized to gait events. Theta power fluctuated across the gait cycle for both conditions, but was greater during incline walking in the anterior cingulate, sensorimotor and posterior parietal clusters. We found greater gamma power during level walking in the left sensorimotor and anterior cingulate clusters. We also found distinct alpha and beta fluctuations, depending on the phase of the gait cycle for the left and right sensorimotor cortices, indicating cortical lateralization for both walking conditions. We validated the results by isolating movement artifact. We found that the frequency activation patterns of the artifact were different than the actual EEG data, providing evidence that the differences between walking conditions were cortically driven rather than a residual artifact of the experiment. These findings suggest that the locomotor pattern adjustments necessary to walk on an incline compared with level surface may require supraspinal input, especially from the left sensorimotor cortex, anterior cingulate, and posterior parietal areas. These results are a promising step toward the use of EEG as a feed-forward control signal for ambulatory brain-computer interface technologies.
C1 [Bradford, J. Cortney] US Army Res Lab, Translat Neurosci Branch, Aberdeen Proving Ground, MD USA.
[Lukos, Jamie R.] Pacific, Appl Res & Adv Concepts Branch, Space & Naval Warfare Syst Ctr SPAWAR, San Diego, CA USA.
[Bradford, J. Cortney; Ferris, Daniel P.] Univ Michigan, Sch Kinesiol, Ann Arbor, MI 48109 USA.
RP Bradford, JC (reprint author), 459 Mulberry Point Rd, Aberdeen Proving Ground, MD 21005 USA.
EM jcbrad@umich.edu
FU Army Research Laboratory
FX Research was sponsored by the Army Research Laboratory and was
accomplished under Cooperative Agreement nos. WN911NF-10-2-0022
(Cognitive and Neuroergonomics Collaborative Technology Alliance) and
WN911NF-10-2-0019 (Oak Ridge Associated Universities).
NR 64
TC 1
Z9 1
U1 1
U2 6
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-3077
EI 1522-1598
J9 J NEUROPHYSIOL
JI J. Neurophysiol.
PD FEB 1
PY 2016
VL 115
IS 2
BP 958
EP 966
DI 10.1152/jn.00089.2015
PG 9
WC Neurosciences; Physiology
SC Neurosciences & Neurology; Physiology
GA DF2EW
UT WOS:000371154800031
PM 26683062
ER
PT J
AU Kauvar, DS
Martin, ED
Givens, MD
AF Kauvar, David S.
Martin, Eric D.
Givens, Matthew D.
TI Thirty-Day Outcomes after Elective Percutaneous or Open Endovascular
Repair of Abdominal Aortic Aneurysms
SO ANNALS OF VASCULAR SURGERY
LA English
DT Article
ID QUALITY IMPROVEMENT PROGRAM; PRECLOSE TECHNIQUE; ACCESS; EXPERIENCE;
SUCCESS
AB Background: Percutaneous endovascular aneurysm repair (PEVAR) has become accepted as a suitable alternative to open EVAR (OEVAR) in the treatment of abdominal aortic aneurysms (AAAs). Direct comparisons between the 2 techniques have been infrequently reported and have predominantly focused on immediate procedural outcomes. The objective of this study was to compare contemporary 30-day postoperative outcomes between successfully completed elective PEVAR and OEVAR.
Methods: The 2012 National Surgical Quality Improvement Program database was queried for all elective primary AAA repairs. Procedures on ruptured AAAs and those involving adjunctive thoracic, abdominal, or extremity procedures were excluded. Cases completed with at least one surgical exposure of the femoral artery for access (OPEN) were compared with those completed without such exposure (PERC). Preoperative, intraoperative, and 30-day postoperative variables were compared using appropriate univariate statistical tests. A P value of <= 0.05 was considered significant for all comparisons.
Results: A total of 1,589 (51%) OPEN and 1,533 (49%) PERC cases met inclusion and exclusion criteria. Preoperative characteristics did not differ between groups. OPEN cases took significantly longer (150 +/- 69 min) than PERC cases (134 +/- 65 min, P < 0.001). No significant differences were found between the groups in any postoperative occurrence, but the rate of venous thromboembolism twice as high in OPEN (16, 1.0%) than PERC cases (7, 0.5%, P = 0.07). In addition, wound complications (36, 2.3% OPEN vs. 23, 1.3% PERC, P = 0.11) were more common in OPEN cases but were diagnosed a week sooner on average in PERC cases (19 days OPEN and 12 days PERC). Median postoperative length of stay was 2 days among OPEN cases versus 1 day in PERC cases (P = 0.11). Female gender and obesity predicted wound complications in the OPEN group but not in the PERC group.
Conclusions: Successfully completed PEVAR and OEVAR have similar rates of overall complications. Female gender and obesity predict wound complications in OEVAR but not in PEVAR, which appears to be a safe alternative to OEVAR. PEVAR has the advantage of shorter operative time and the potential for a shorter postoperative stay, and may offer the advantage of fewer wound complications in females and obese patients.
C1 [Kauvar, David S.; Martin, Eric D.] Dwight D Eisenhower Army Med Ctr, Dept Surg, Ft Gordon, GA USA.
[Kauvar, David S.] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA.
[Givens, Matthew D.] Dwight D Eisenhower Army Med Ctr, Dept Radiol, Ft Gordon, GA USA.
RP Kauvar, DS (reprint author), DDEAMC, Dept Surg, 300 Hosp Dr, Ft Gordon, GA 30905 USA.
EM davekauvar@gmail.com
NR 16
TC 2
Z9 3
U1 1
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0890-5096
EI 1615-5947
J9 ANN VASC SURG
JI Ann. Vasc. Surg.
PD FEB
PY 2016
VL 31
BP 46
EP 51
DI 10.1016/j.avsg.2015.10.009
PG 6
WC Surgery; Peripheral Vascular Disease
SC Surgery; Cardiovascular System & Cardiology
GA DD8XX
UT WOS:000370211300007
PM 26658092
ER
PT J
AU Nyland, JE
Alexander, DN
Grigson, PS
AF Nyland, Jennifer E.
Alexander, Danielle N.
Grigson, Patricia S.
TI Drug-Motivated Behavior in Rats With Lesions of the Thalamic Orosensory
Area
SO BEHAVIORAL NEUROSCIENCE
LA English
DT Article
DE trigeminal orosensory area; thalamus; motivated behavior; morphine;
cocaine
ID PHYSICAL-DEPENDENCE LIABILITY; CONDITIONED PLACE PREFERENCE; PAIRED
TASTE CUE; LITHIUM-CHLORIDE; SACCHARIN INTAKE; ANTICIPATORY CONTRAST;
INDUCED SUPPRESSION; GUSTATORY THALAMUS; CORN-OIL; EXCITOTOXIC LESIONS
AB Rats suppress intake of a palatable taste cue when paired with a rewarding or an aversive stimulus in appetitive or aversive conditioning, respectively. A similar phenomenon occurs with drugs of abuse, but the nature of this conditioning has been subject for debate. While relatively little is known about the underlying neural circuitry, we recently reported bilateral lesions of the thalamic trigeminal orosensory area isolate drug-induced suppression of intake of a taste cue. The lesion blocks avoidance of the taste cue when paired with experimenter delivered drugs of abuse, yet has no effect on avoidance of the same cue when paired with an aversive agent or when it predicts access to a highly palatable sucrose solution. We hypothesize the lesion may blunt the rewarding properties of the drug. To test this, we used a runway apparatus, as running speed has been shown to increase with increasing reward value. Our hypothesis was supported by failure of the lesioned rats to increase running speed for morphine. Interestingly, lesioned rats did avoid intake of the drug-paired cue when presented in the runway apparatus and displayed naloxone-precipitated withdrawal. Using a partial crossover design, the lesion prevented avoidance of a cocaine-paired cue when presented in the home cage. We conclude that the lesion disrupts avoidance of a taste cue in anticipation of the rewarding properties of a drug but, at least in the presence of contextual cues, allows for avoidance of a taste cue as it elicits the onset of an aversive conditioned state of withdrawal.
C1 [Nyland, Jennifer E.; Alexander, Danielle N.; Grigson, Patricia S.] Penn State Univ, Dept Neural & Behav Sci, University Pk, PA 16802 USA.
RP Nyland, JE (reprint author), US Army, Battlefield Pain Management, Inst Surg Res, Houston, TX 78234 USA.
EM jen.e.nyland@gmail.com
OI Grigson, Patricia/0000-0002-4252-7332
FU [DA0012473]; [DA009815]; [F31-DA029369]
FX This research article was supported by Grants DA0012473, DA009815, and
F31-DA029369.
NR 79
TC 0
Z9 0
U1 0
U2 3
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0735-7044
EI 1939-0084
J9 BEHAV NEUROSCI
JI Behav. Neurosci.
PD FEB
PY 2016
VL 130
IS 1
BP 103
EP 113
DI 10.1037/bne0000114
PG 11
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA DE6LK
UT WOS:000370745000011
PM 26653714
ER
PT J
AU Garg, S
Thongcharoen, P
Praphasiri, P
Chitwarakorn, A
Sathirapanya, P
Fernandez, S
Rungrojcharoenkit, K
Chonwattana, W
Mock, PA
Sukwicha, W
Katz, JM
Widdowson, MA
Curlin, ME
Gibbons, RV
Holtz, TH
Dawood, FS
Olsen, SJ
AF Garg, Shikha
Thongcharoen, Prasert
Praphasiri, Prabda
Chitwarakorn, Anupong
Sathirapanya, Pornchai
Fernandez, Stefan
Rungrojcharoenkit, Kamonthip
Chonwattana, Wannee
Mock, Philip A.
Sukwicha, Wichuda
Katz, Jacqueline M.
Widdowson, Marc-Alain
Curlin, Marcel E.
Gibbons, Robert V.
Holtz, Timothy H.
Dawood, Fatimah S.
Olsen, Sonja J.
TI Randomized Controlled Trial to Compare Immunogenicity of Standard-Dose
Intramuscular Versus Intradermal Trivalent Inactivated Influenza Vaccine
in HIV-Infected Men Who Have Sex With Men in Bangkok, Thailand
SO CLINICAL INFECTIOUS DISEASES
LA English
DT Article
DE influenza; vaccine; HIV; immunogenicity; intradermal
ID A H1N1 VACCINE; ANTIBODY-RESPONSE; HIV-1-INFECTED PATIENTS;
IMMUNE-RESPONSE; CLINICAL-TRIAL; SPLIT VIRION; DOUBLE-BLIND; ADULTS;
EFFICACY; INDIVIDUALS
AB Background. Individuals infected with human immunodeficiency virus (HIV) are at increased risk for severe influenza, yet immune responses to standard-dose intramuscular (IM) influenza vaccine are suboptimal in this population. Intradermal (ID) delivery of influenza vaccine might improve immune response through enhanced stimulation of dendritic cells.
Methods. We conducted a randomized, double-blind, controlled trial to compare the immunogenicity of off-label standard-dose (15 mu g) ID vs standard-dose (15 mu g) IM inactive influenza vaccine in HIV-infected men in Bangkok, Thailand. The primary study outcome was seroconversion (minimum titer of 1:40 and >= 4-fold rise in antibody titer) at 1 month postvaccination based on serum hemagglutination inhibition antibody titers against each vaccine strain. Adverse events (AEs) in the 7 days following vaccination were also assessed.
Results. We enrolled 400 HIV-infected participants; 200 were randomly assigned to receive IM and 200 ID vaccine. Vaccine arms were well-balanced with respect to age, CD4 cell count, HIV RNA load, and antiretroviral treatment. Percentage of seroconversion to all (ID 14% vs IM 15%; P=.8) or at least 1 (ID 69% vs IM 68%; P=.7) of the 3 vaccine strains did not differ significantly between ID vs IM vaccine recipients. A higher proportion of participants who received ID vaccine had mild injection-site AEs compared with participants who received IM vaccine (77% vs 27%).
Conclusions. There were no significant differences in the immunogenicity of standard-dose ID vs IM influenza vaccine in this HIV-infected population in Thailand. Additional strategies to enhance immune responses to influenza vaccine among HIV-infected persons are needed.
C1 [Garg, Shikha; Curlin, Marcel E.; Holtz, Timothy H.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30329 USA.
[Garg, Shikha; Katz, Jacqueline M.; Widdowson, Marc-Alain; Dawood, Fatimah S.; Olsen, Sonja J.] Ctr Dis Control & Prevent, Influenza Div, 1600 Clifton Rd NE,Mailstop A-32, Atlanta, GA 30329 USA.
[Praphasiri, Prabda; Chonwattana, Wannee; Mock, Philip A.; Sukwicha, Wichuda; Curlin, Marcel E.; Holtz, Timothy H.; Olsen, Sonja J.] Ctr Dis Control & Prevent, Thailand Minist Publ Health US CDC Collaborat, Atlanta, GA USA.
[Chitwarakorn, Anupong] Minist Publ Hlth, Dept Dis Control, Nonthaburi, Thailand.
[Fernandez, Stefan; Rungrojcharoenkit, Kamonthip; Gibbons, Robert V.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
[Thongcharoen, Prasert; Sathirapanya, Pornchai] Siriraj Hosp, Bangkok, Thailand.
RP Garg, S (reprint author), Ctr Dis Control & Prevent, Influenza Div, 1600 Clifton Rd NE,Mailstop A-32, Atlanta, GA 30329 USA.
EM izj7@cdc.gov
FU CDC [5U01GH000152]
FX This work was supported by the CDC (cooperative agreement 5U01GH000152).
NR 43
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U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1058-4838
EI 1537-6591
J9 CLIN INFECT DIS
JI Clin. Infect. Dis.
PD FEB 1
PY 2016
VL 62
IS 3
BP 383
EP 391
DI 10.1093/cid/civ884
PG 9
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA DD8VS
UT WOS:000370205600021
PM 26486702
ER
PT J
AU Gorzalski, AS
Spiesman, AL
AF Gorzalski, Alexander S.
Spiesman, Anne L.
TI Washington Aqueduct: Serving Our Nation's Capital for Over 150 Years
SO JOURNAL AMERICAN WATER WORKS ASSOCIATION
LA English
DT Article
C1 [Gorzalski, Alexander S.; Spiesman, Anne L.] US Army Corps Engineers, 5900 MacArthur Blvd NW, Washington, DC 20016 USA.
RP Gorzalski, AS (reprint author), US Army Corps Engineers, 5900 MacArthur Blvd NW, Washington, DC 20016 USA.
EM Alexander.S.Gorzalski@usace.army.mil
NR 11
TC 0
Z9 0
U1 0
U2 0
PU AMER WATER WORKS ASSOC
PI DENVER
PA 6666 W QUINCY AVE, DENVER, CO 80235 USA
SN 2164-4535
J9 J AM WATER WORKS ASS
JI J. Am. Water Work Assoc.
PD FEB
PY 2016
VL 108
IS 2
BP 40
EP 47
DI 10.5942/jawwa.2016.108.0034
PG 8
WC Engineering, Civil; Water Resources
SC Engineering; Water Resources
GA DD8VQ
UT WOS:000370205400009
ER
PT J
AU Jenicek, EM
Garfinkle, NW
Curvey, LE
Case, MP
Choi, M
Stumpf, AL
AF Jenicek, Elisabeth M.
Garfinkle, Noah W.
Curvey, Laura E.
Case, Michael P.
Choi, Marianne
Stumpf, Annette L.
TI Methods of Estimating Water End Use at US Army Installations
SO JOURNAL AMERICAN WATER WORKS ASSOCIATION
LA English
DT Article
C1 [Jenicek, Elisabeth M.] US Army Corps Engineers, Engineer Res & Dev Ctr, POB 9005, Champaign, IL 61826 USA.
RP Jenicek, EM (reprint author), US Army Corps Engineers, Engineer Res & Dev Ctr, POB 9005, Champaign, IL 61826 USA.
EM elisabeth.m.jenicek@usace.army.mil
NR 0
TC 0
Z9 0
U1 1
U2 2
PU AMER WATER WORKS ASSOC
PI DENVER
PA 6666 W QUINCY AVE, DENVER, CO 80235 USA
SN 2164-4535
J9 J AM WATER WORKS ASS
JI J. Am. Water Work Assoc.
PD FEB
PY 2016
VL 108
IS 2
BP 54
EP 54
DI 10.5942/jawwa.2016.108.0004
PG 1
WC Engineering, Civil; Water Resources
SC Engineering; Water Resources
GA DD8VQ
UT WOS:000370205400011
ER
PT J
AU Reen, BP
Dumais, RE
Passner, JE
AF Reen, Brian P.
Dumais, Robert E., Jr.
Passner, Jeffrey E.
TI Mitigating Excessive Drying from the Use of Observations in Mesoscale
Modeling
SO JOURNAL OF APPLIED METEOROLOGY AND CLIMATOLOGY
LA English
DT Article
DE Data assimilation; Numerical weather prediction/forecasting; Model
initialization; Mesoscale models
ID 4-DIMENSIONAL DATA ASSIMILATION; PLANETARY BOUNDARY-LAYER; AIR-QUALITY
SIMULATIONS; ENSEMBLE KALMAN FILTER; PART I; METEOROLOGICAL MODEL; RADAR
OBSERVATIONS; PREDICTION; IMPACT; SYSTEM
AB Observations can be used to enhance mesoscale model forecasts by both improving the initial conditions and adjusting the model state toward the observations during its forward integration. Since observations are not available at the same density as the model grid points, spatial and temporal error correlations must be specified in order to effectively assimilate the observations into the model. Overdrying is found while applying the Weather Research and Forecasting Model to five cases centered over Southern California. This overdrying is caused by incorporation of observations in the initial conditions both at a discrete time and over a preforecast data assimilation period. Nonphysical dryness results from the assumption that model moisture error at the observation location is correlated with model moisture error at other locations in the model without regard to the relative magnitude of the moisture at those two locations. Modifying the model and its preprocessor to remove this assumption greatly reduces the occurrence of excessive model dryness without degrading the overall model performance in predicting moisture.
C1 [Reen, Brian P.] US Army, Res Lab, Battlefield Environm Div, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
[Dumais, Robert E., Jr.; Passner, Jeffrey E.] US Army, Res Lab, Battlefield Environm Div, White Sands Missile Range, NM USA.
RP Reen, BP (reprint author), US Army, Res Lab, Battlefield Environm Div, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM brian.p.reen.civ@mail.mil
FU National Research Council postdoctoral associateship at the Army
Research Laboratory
FX AirDat LLC provided TAMDAR observational data that expanded the
above-surface data available for data assimilation and verification.
This study was made possible in part due to the data made available to
the National Oceanic and Atmospheric Administration by various providers
for inclusion in MADIS. The RTMA use and reject lists were provided by
Steve Levine at the National Centers for Environmental Prediction's
Environmental Modeling Center and greatly facilitated making full use of
the MADIS observational dataset. The madis2littler tool was provided by
Ruifang Li then at the National Center for Atmospheric Research. The
first author was supported by a National Research Council postdoctoral
associateship at the Army Research Laboratory for part of this research.
We thank three anonymous reviewers for their comments, which led to
improvements in this manuscript.
NR 47
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Z9 0
U1 1
U2 2
PU AMER METEOROLOGICAL SOC
PI BOSTON
PA 45 BEACON ST, BOSTON, MA 02108-3693 USA
SN 1558-8424
EI 1558-8432
J9 J APPL METEOROL CLIM
JI J. Appl. Meteorol. Climatol.
PD FEB
PY 2016
VL 55
IS 2
BP 365
EP 388
DI 10.1175/JAMC-D-14-0301.1
PG 24
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA DE1WZ
UT WOS:000370418500001
ER
PT J
AU Bates, ME
Keisler, JM
Zussblatt, NP
Plourde, KJ
Wender, BA
Linkov, I
AF Bates, Matthew E.
Keisler, Jeffrey M.
Zussblatt, Niels P.
Plourde, Kenton J.
Wender, Ben A.
Linkov, Igor
TI Balancing research and funding using value of information and portfolio
tools for nanomaterial risk classification
SO NATURE NANOTECHNOLOGY
LA English
DT Article
AB Risk research for nanomaterials is currently prioritized by means of expert workshops and other deliberative processes. However, analytical techniques that quantify and compare alternative research investments are increasingly recommended. Here, we apply value of information and portfolio decision analysis methods commonly applied in financial and operations management to prioritize risk research for multiwalled carbon nanotubes and nanoparticulate silver and titanium dioxide. We modify the widely accepted CB Nanotool hazard evaluation framework, which combines nano- and bulk-material properties into a hazard score, to operate probabilistically with uncertain inputs. Literature is reviewed to develop uncertain estimates for each input parameter, and a Monte Carlo simulation is applied to assess how different research strategies can improve hazard classification. The relative cost of each research experiment is elicited from experts, which enables identification of efficient research portfolios combinations of experiments that lead to the greatest improvement in hazard classification at the lowest cost. Nanoparticle shape, diameter, solubility and surface reactivity were most frequently identified within efficient portfolios in our results.
C1 [Bates, Matthew E.; Zussblatt, Niels P.; Plourde, Kenton J.; Wender, Ben A.; Linkov, Igor] US Army Corps Engineers, Environm Lab, Engn Res & Dev Ctr, 696 Virginia Rd, Concord, MA 01742 USA.
[Keisler, Jeffrey M.] Univ Massachusetts, Management Sci & Informat Syst Dept, 100 Morrissey Blvd, Boston, MA 02125 USA.
[Zussblatt, Niels P.] Univ Calif Santa Barbara, Dept Chem Engn, Mail Code 5080, Santa Barbara, CA 93106 USA.
[Wender, Ben A.] Arizona State Univ, Sch Sustainable Engn & Built Environm, POB 875306, Tempe, AZ 85287 USA.
RP Bates, ME; Linkov, I (reprint author), US Army Corps Engineers, Environm Lab, Engn Res & Dev Ctr, 696 Virginia Rd, Concord, MA 01742 USA.
EM matthew.e.bates@usace.army.mil; igor.linkov@usace.army.mil
FU US Army Engineer Research and Development Center; Environmental
Protection Agency 'Science to Achieve Results' programme [FP917643];
National Science Foundation [ECCS-1140190, SES-0937591]
FX This work was funded by the nanotechnology and emerging material risk
research programmes of the US Army Engineer Research and Development
Center, by the Environmental Protection Agency 'Science to Achieve
Results' programme through grant no. FP917643, and the National Science
Foundation through grants nos. ECCS-1140190 and SES-0937591. Publication
of this material has been approved by the authority of the Chief of the
US Army Corps of Engineers.
NR 16
TC 2
Z9 2
U1 4
U2 13
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1748-3387
EI 1748-3395
J9 NAT NANOTECHNOL
JI Nat. Nanotechnol.
PD FEB
PY 2016
VL 11
IS 2
BP 198
EP 203
DI 10.1038/NNANO.2015.249
PG 6
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary
SC Science & Technology - Other Topics; Materials Science
GA DE6UR
UT WOS:000370769600019
PM 26551015
ER
PT J
AU Zhao, ZW
Liao, WC
Bhagavatula, N
Lee, LJ
Castro, JM
AF Zhao, Ziwei
Liao, Wei-Ching
Bhagavatula, Narayan
Lee, L. James
Castro, Jose M.
TI Permeability Measurements and Flow Simulation for Polyaniline Carbon
Nanofibers Modified Nanopaper on Glass Fiber Preform
SO POLYMER COMPOSITES
LA English
DT Article
ID MECHANICAL-PROPERTIES; COMPOSITES; REINFORCEMENT; FABRICATION;
ELASTOMERS; COATINGS; MOLDS; MATS; PART
AB Carbon nanofibers (CNFs) nanopapers have shown great potential to improve the surface of fiber-reinforced polymeric composites, including providing electromagnetic interference shielding and erosion resistance. During typical resin transfer molding (RTM) process, the CNF nanopaper is incorporated into the fiber preform as a surface layer. To learn how resin flows through the fiber preform and nanopaper layer, permeabilities of the fiber preform and nanopaper need to be measured. As is well known, measuring the permeability of fiber preforms is experimentally challenging. Results usually exhibit large experimental variability. Measuring permeability of nanopapers is even more complicated. To improve the accuracy of results, permeability of CNF-based nanopapers was measured using different experimental setups. In-plane permeability of nanopaper was measured by both unidirectional microslit flow and radial flow approaches. Trans-plane permeability was measured as well, using a trans-plane flow cell and a flow visualization mold. In this article, we discuss the methods used and provide experimental results. We also conducted computational fluid dynamics simulations to study the detailed flow patterns of the nanopaper/RTM process and compared the simulated effect of the nanopaper on retarding the flow (length of the lag) with respect to the glass preform with flow visualization results. (C) 2014 Society of Plastics Engineers
C1 [Zhao, Ziwei; Castro, Jose M.] Ohio State Univ, Dept Integrated Syst Engn, 1971 Neil Ave, Columbus, OH 43210 USA.
[Liao, Wei-Ching; Lee, L. James] Ohio State Univ, Dept Chem & Biomol Engn, 140 West 19th Ave,125 Koffolt Labs, Columbus, OH 43210 USA.
[Bhagavatula, Narayan] US ARMY RDECOM ARDEC, Picatinny Arsenal, NJ 07852 USA.
RP Castro, JM (reprint author), Ohio State Univ, Dept Integrated Syst Engn, 1971 Neil Ave, Columbus, OH 43210 USA.
EM castro.38@osu.edu
NR 29
TC 1
Z9 1
U1 6
U2 18
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0272-8397
EI 1548-0569
J9 POLYM COMPOSITE
JI Polym. Compos.
PD FEB
PY 2016
VL 37
IS 2
BP 435
EP 445
DI 10.1002/pc.23197
PG 11
WC Materials Science, Composites; Polymer Science
SC Materials Science; Polymer Science
GA DE2XD
UT WOS:000370489900014
ER
PT J
AU Patel, RB
Stepanov, V
Swaszek, S
Surapaneni, A
Qiu, HW
AF Patel, Rajen B.
Stepanov, Victor
Swaszek, Sean
Surapaneni, Ashok
Qiu, Hongwei
TI Investigation of CL-20 and RDX Nanocomposites
SO PROPELLANTS EXPLOSIVES PYROTECHNICS
LA English
DT Article
DE Nitramine; Explosives; Nanoenergetic; Spray drying; Sensitivity
ID RAMAN-SPECTROSCOPY; PARTICLE-SIZE; INITIATION; DEPENDENCE; HMX
AB Nanocrystalline explosives offer a number of advantages in comparison to conventional energetics including reduced sensitivity and improved mechanical properties. In this study, formulations consisting of 90% hexanitro-hexaazaisowurtzitane (CL-20) or cyclotrimethylene trinitramine (RDX) and 10% polyvinyl alcohol (PVOH) were prepared with mean crystal sizes ranging from 200nm to 2m. The process to create these materials used a combination of aqueous mechanical crystal size reduction and spray drying. The basic physical characteristics of these formulations were determined using a variety of techniques, including scanning electron microscopy, X-ray diffraction, and Raman spectroscopy. Compressive stress-strain tests on pressed pellets revealed that the mechanical properties of the compositions improved with decreasing crystal size, consistent with Hall-Petch mechanics. In the most extreme case (involving CL-20/PVOH formulations), crystal size reduction from 2m to 300nm improved compressive strength and Young's modulus by 126% and 61%, respectively. These results serve to highlight the relevance of structure-property relationships in explosive compositions, and particularly elucidate the substantial benefits of reducing the high explosive crystal size to nanoscale dimensions.
C1 [Patel, Rajen B.; Stepanov, Victor; Swaszek, Sean; Surapaneni, Ashok] US Army, Energet & Warheads Mfg & Technol Div, Picatinny Arsenal, NJ 07806 USA.
[Qiu, Hongwei] Leidos Inc, Picatinny Arsenal, NJ 07806 USA.
RP Patel, RB; Stepanov, V (reprint author), US Army, Energet & Warheads Mfg & Technol Div, Picatinny Arsenal, NJ 07806 USA.
EM rajen.b.patel.civ@mail.mil; victor.stepanov.civ@mail.mil
FU US Department of Defense
FX This work was performed under the auspices of the US Department of
Defense.
NR 30
TC 2
Z9 2
U1 8
U2 21
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 0721-3115
EI 1521-4087
J9 PROPELL EXPLOS PYROT
JI Propellants Explos. Pyrotech.
PD FEB
PY 2016
VL 41
IS 1
BP 114
EP 119
DI 10.1002/prep.201500130
PG 6
WC Chemistry, Applied; Engineering, Chemical
SC Chemistry; Engineering
GA DE0RZ
UT WOS:000370333300014
ER
PT J
AU Stepanov, V
Patel, RB
Mudryy, R
Qiu, HW
AF Stepanov, Victor
Patel, Rajen B.
Mudryy, Ruslan
Qiu, Hongwei
TI Investigation of Nitramine-Based Amorphous Energetics
SO PROPELLANTS EXPLOSIVES PYROTECHNICS
LA English
DT Article
DE Amorphous; Glassy; Energetics; Nitramine; CL-20; Spray drying
ID CRYSTALLIZATION; INDOMETHACIN; DISPERSIONS; SENSITIVITY
AB To date, the use of high explosives (HEs) has been largely limited to their crystalline forms. The glassy forms of these materials have not received much attention. While the highest density and stability of HEs is only attainable in the crystalline state, the unique properties exhibited by glasses may offer significant practical advantages. In this work, the production and properties of glassy molecular dispersions based on CL-20 with HMX and polyvinyl acetate additives were investigated. The glassy form was achieved by rapid precipitation of the composite ingredients using spray drying. The role of the additives on glass formation was examined. Characterization revealed multiple novel properties in comparison to the traditional crystalline HE-based compositions. Differential scanning calorimetry (DSC) analysis showed that in the glassy state the materials have a higher configurational enthalpy, by as much as 42Jg(-1). Thermomechanical analysis (TMA) results indicate that the glassy materials undergo a glass transition at around 50 degrees C, during which a transformation from a rigid to a liquid-like state occurs. The glasses showed a tendency to crystallize, as was observed with TMA and DSC analysis. It was observed that the stability of the amorphous phase with respect to crystallization improved with increasing pellet density. These findings serve to highlight the unique opportunity presented by glassy energetics to achieve improvements beyond those attainable with traditional crystalline materials.
C1 [Stepanov, Victor; Patel, Rajen B.; Mudryy, Ruslan] US Army, RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA.
[Qiu, Hongwei] Leidos Inc, Picatinny Arsenal, NJ 07806 USA.
RP Stepanov, V (reprint author), US Army, RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA.
EM victor.stepanov.civ@mail.mil
FU U.S. Department of Defense
FX This work was performed under the auspices of the U.S. Department of
Defense.
NR 19
TC 0
Z9 0
U1 4
U2 8
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 0721-3115
EI 1521-4087
J9 PROPELL EXPLOS PYROT
JI Propellants Explos. Pyrotech.
PD FEB
PY 2016
VL 41
IS 1
BP 142
EP 147
DI 10.1002/prep.201500118
PG 6
WC Chemistry, Applied; Engineering, Chemical
SC Chemistry; Engineering
GA DE0RZ
UT WOS:000370333300018
ER
PT J
AU Abraham, A
Piekiel, NW
Morris, CJ
Dreizin, EL
AF Abraham, Ani
Piekiel, Nicholas W.
Morris, Christopher J.
Dreizin, Edward L.
TI Combustion of Energetic Porous Silicon Composites Containing Different
Oxidizers
SO PROPELLANTS EXPLOSIVES PYROTECHNICS
LA English
DT Article
DE Porous silicon; On-chip energetic materials; Combustion; Sulfur; Nitrate
ID FILMS
AB We present a quantitative investigation of combustion of on-chip porous silicon (PS) energetic materials using oxidizers with improved moisture stability and/or minimized environmental impact compared to sodium perchlorate (NaClO4). Material properties of the PS films were characterized using gas adsorption porosimetry and profilometry to determine specific surface area, porosity, and etch depth. PS energetic composites were formed using melt-penetrated or solution-deposited oxidizers into the pores. Combustion was characterized by high speed imaging and bomb calorimetry. The flame speeds quantified for PS/sulfur and PS/nitrate systems varied in the ranges of 2.9-3.7ms(-1)and 3.1-21ms(-1), respectively. The experimental combustion enthalpies are reported for different oxidizer systems in both inert and oxidizing environments. For the PS/sulfur and the PS/nitrate systems, the experimental heats of combustion were comparable to those calculated for the thermodynamic equilibrium and taking into account an increased reactivity of PS due to the hydrogen terminated silicon surface.
C1 [Abraham, Ani; Piekiel, Nicholas W.; Morris, Christopher J.] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
[Abraham, Ani; Dreizin, Edward L.] New Jersey Inst Technol, Newark, NJ 07102 USA.
RP Morris, CJ (reprint author), US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
EM christopher.j.morris58.civ@mail.mil
RI Dreizin, Edward/O-6416-2014
NR 37
TC 2
Z9 2
U1 1
U2 10
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 0721-3115
EI 1521-4087
J9 PROPELL EXPLOS PYROT
JI Propellants Explos. Pyrotech.
PD FEB
PY 2016
VL 41
IS 1
BP 179
EP 188
DI 10.1002/prep.201500108
PG 10
WC Chemistry, Applied; Engineering, Chemical
SC Chemistry; Engineering
GA DE0RZ
UT WOS:000370333300024
ER
PT J
AU Singh, J
Haines, C
AF Singh, Jogender
Haines, Chris
TI FIELD ASSISTED SINTERING TECHNOLOGY UPDATE-PART I
SO ADVANCED MATERIALS & PROCESSES
LA English
DT Editorial Material
C1 [Singh, Jogender] Penn State Univ, Dept Mat Sci & Engn, FAST Ctr Excellence, University Pk, PA 16801 USA.
[Haines, Chris] US Army, RDECOM, ARDEC, Picatinny Arsenal, NJ USA.
RP Singh, J (reprint author), Penn State Univ, Dept Mat Sci & Engn, FAST Ctr Excellence, University Pk, PA 16801 USA.
EM jxs46@psu.edu
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ASM INT
PI MATERIALS PARK
PA SUBSCRIPTIONS SPECIALIST CUSTOMER SERVICE, MATERIALS PARK, OH 44073-0002
USA
SN 0882-7958
EI 2161-9425
J9 ADV MATER PROCESS
JI Adv. Mater. Process.
PD FEB
PY 2016
VL 174
IS 2
BP 20
EP 24
PG 5
WC Materials Science, Multidisciplinary
SC Materials Science
GA DD2VP
UT WOS:000369780600010
ER
PT J
AU Akkina, R
Allam, A
Balazs, AB
Blankson, JN
Burnett, JC
Casares, S
Garcia, JV
Hasenkrug, KJ
Kashanchi, F
Kitchen, SG
Klein, F
Kumar, P
Luster, AD
Poluektova, LY
Rao, M
Sanders-Beer, BE
Shultz, LD
Zack, JA
AF Akkina, Ramesh
Allam, Atef
Balazs, Alejandro B.
Blankson, Joel N.
Burnett, John C.
Casares, Sofia
Garcia, J. Victor
Hasenkrug, Kim J.
Kashanchi, Fatah
Kitchen, Scott G.
Klein, Florian
Kumar, Priti
Luster, Andrew D.
Poluektova, Larisa Y.
Rao, Mangala
Sanders-Beer, Brigitte E.
Shultz, Leonard D.
Zack, Jerome A.
TI Improvements and Limitations of Humanized Mouse Models for HIV Research:
NIH/NIAID "Meet the Experts" 2015 Workshop Summary
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Article
ID IMMUNODEFICIENCY-VIRUS ENCEPHALITIS; BROADLY NEUTRALIZING ANTIBODIES;
HEMATOPOIETIC STEM-CELLS; SCID-HU MOUSE; T-CELLS; BLT MICE; IN-VIVO;
VAGINAL TRANSMISSION; INFECTIOUS-DISEASES; IMMUNE-RESPONSES
AB The number of humanized mouse models for the human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) and other infectious diseases has expanded rapidly over the past 8 years. Highly immunodeficient mouse strains, such as NOD/SCID/gamma chain(null) (NSG, NOG), support better human hematopoietic cell engraftment. Another improvement is the derivation of highly immunodeficient mice, transgenic with human leukocyte antigens (HLAs) and cytokines that supported development of HLA-restricted human T cells and heightened human myeloid cell engraftment. Humanized mice are also used to study the HIV reservoir using new imaging techniques. Despite these advances, there are still limitations in HIV immune responses and deficits in lymphoid structures in these models in addition to xenogeneic graft-versus-host responses. To understand and disseminate the improvements and limitations of humanized mouse models to the scientific community, the NIH sponsored and convened a meeting on April 15, 2015 to discuss the state of knowledge concerning these questions and best practices for selecting a humanized mouse model for a particular scientific investigation. This report summarizes the findings of the NIH meeting.
C1 [Akkina, Ramesh] Colorado State Univ, Dept Microbiol Immunol & Pathol, Ft Collins, CO 80523 USA.
[Allam, Atef] Henry M Jackson Fdn Adv Mil Med, Silver Spring, MD USA.
[Allam, Atef; Rao, Mangala] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
[Balazs, Alejandro B.] Ragon Inst MGH MIT & Harvard, Cambridge, MA USA.
[Blankson, Joel N.] Johns Hopkins Univ, Sch Med, Dept Med, Ctr AIDS Res, Baltimore, MD 21205 USA.
[Burnett, John C.] Beckman Res Inst City Hope, Dept Mol & Cellular Biol, Duarte, CA USA.
[Casares, Sofia] Naval Med Res Ctr, US Mil Malaria Vaccine Program, Silver Spring, MD USA.
[Garcia, J. Victor] Univ N Carolina, Dept Med, Div Infect Dis, UNC Ctr AIDS Res, Chapel Hill, NC USA.
[Hasenkrug, Kim J.] NIAID, Lab Persistent Viral Dis, Rocky Mt Labs, NIH, Hamilton, MT USA.
[Kashanchi, Fatah] George Mason Univ, Sch Syst Biol, Natl Ctr Biodef & Infect Dis, Manassas, VA USA.
[Kitchen, Scott G.; Zack, Jerome A.] Univ Calif Los Angeles, AIDS Inst, Dept Med & Microbiol, Los Angeles, CA USA.
[Kitchen, Scott G.; Zack, Jerome A.] Univ Calif Los Angeles, AIDS Inst, Dept Immunol & Mol Genet, Los Angeles, CA USA.
[Klein, Florian] Univ Hosp Cologne, Dept Internal Med 1, Cologne, Germany.
[Klein, Florian] Univ Cologne, CMMC, D-50931 Cologne, Germany.
[Kumar, Priti] Yale Univ, Sch Med, Infect Dis Internal Med, New Haven, CT USA.
[Luster, Andrew D.] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Div Rheumatol Allergy & Immunol,Ctr Immunol & Inf, Boston, MA 02115 USA.
[Poluektova, Larisa Y.] Univ Nebraska Med Ctr, Dept Pharmacol & Expt Neurosci, Omaha, NE USA.
[Sanders-Beer, Brigitte E.] NIAID, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
[Shultz, Leonard D.] Jackson Lab, 600 Main St, Bar Harbor, ME 04609 USA.
RP Sanders-Beer, BE (reprint author), NIAID, BSP, DAIDS, NIH,DHHS, 5601 Fishers Lane,Room 9G58, Rockville, MD 20852 USA.
EM sandersbe@niaid.nih.gov
OI Burnett, John/0000-0002-8817-6064
FU National Institute of Allergies and Infectious Diseases, National
Institutes of Health, Department of Health and Human Services
[HHSN272201100001G]
FX The workshop was funded in whole with Federal funds from the National
Institute of Allergies and Infectious Diseases, National Institutes of
Health, Department of Health and Human Services, under contract no.
HHSN272201100001G.
NR 76
TC 3
Z9 3
U1 1
U2 3
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD FEB 1
PY 2016
VL 32
IS 2
BP 109
EP 119
DI 10.1089/aid.2015.0258
PG 11
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA DD2NY
UT WOS:000369760500001
PM 26670361
ER
PT J
AU Bushman, TT
Grier, TL
Canham-Chervak, M
Anderson, MK
North, WJ
Jones, BH
AF Bushman, Timothy T.
Grier, Tyson L.
Canham-Chervak, Michelle
Anderson, Morgan K.
North, William J.
Jones, Bruce H.
TI The Functional Movement Screen and Injury Risk: Association and
Predictive Value in Active Men
SO AMERICAN JOURNAL OF SPORTS MEDICINE
LA English
DT Article
DE military training; epidemiology; injury prevention; Functional Movement
Screen; predictive value
ID INTERRATER RELIABILITY; INTRARATER RELIABILITY; INFANTRY; SOLDIERS;
FITNESS
AB Background: The Functional Movement Screen (FMS) is a series of 7 tests used to assess the injury risk in active populations.
Purpose: To determine the association of the FMS with the injury risk, assess predictive values, and identify optimal cut points using 3 injury types.
Study Design: Cohort study; Level of evidence, 2.
Methods: Physically active male soldiers aged 18 to 57 years (N = 2476) completed the FMS. Demographic and fitness data were collected by survey. Medical record data for overuse injuries, traumatic injuries, and any injury 6 months after the FMS assessment were obtained. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated along with the receiver operating characteristic (ROC) to determine the area under the curve (AUC) and identify optimal cut points for the risk assessment. Risks, risk ratios (RRs), odds ratios (ORs), and 95% CIs were calculated to assess injury risks.
Results: Soldiers who scored 14 were at a greater risk for injuries compared with those who scored >14 using the composite score for overuse injuries (RR, 1.84; 95% CI, 1.63-2.09), traumatic injuries (RR, 1.26; 95% CI, 1.03-1.54), and any injury (RR, 1.60; 95% CI, 1.45-1.77). When controlling for other known injury risk factors, multivariate logistic regression analysis identified poor FMS performance (OR [score 14/19-21], 2.00; 95% CI, 1.42-2.81) as an independent risk factor for injuries. A cut point of 14 registered low measures of predictive value for all 3 injury types (sensitivity, 28%-37%; PPV, 19%-52%; AUC, 54%-61%). Shifting the injury risk cut point of 14 to the optimal cut points indicated by the ROC did not appreciably improve sensitivity or the PPV.
Conclusion: Although poor FMS performance was associated with a higher risk of injuries, it displayed low sensitivity, PPV, and AUC. On the basis of these findings, the use of the FMS to screen for the injury risk is not recommended in this population because of the low predictive value and misclassification of the injury risk.
C1 [Bushman, Timothy T.; Grier, Tyson L.; Canham-Chervak, Michelle; Anderson, Morgan K.; Jones, Bruce H.] US Army, Inst Publ Hlth, Directorate Epidemiol & Dis Surveillance, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA.
[North, William J.] Henry Jackson Fdn, Ft Carson, CO USA.
RP Bushman, TT (reprint author), US Army, Inst Publ Hlth, Directorate Epidemiol & Dis Surveillance, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA.
EM Timothy.t.bushman.ctr@mail.mil
NR 43
TC 1
Z9 1
U1 6
U2 21
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0363-5465
EI 1552-3365
J9 AM J SPORT MED
JI Am. J. Sports Med.
PD FEB
PY 2016
VL 44
IS 2
BP 297
EP 304
DI 10.1177/0363546515614815
PG 8
WC Orthopedics; Sport Sciences
SC Orthopedics; Sport Sciences
GA DD5RZ
UT WOS:000369983300004
PM 26657573
ER
PT J
AU Boddu, VM
Brenner, MW
AF Boddu, Veera M.
Brenner, Matthew W.
TI Energy dissipation in intercalated carbon nanotube forests with metal
layers
SO APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
LA English
DT Article
ID MECHANICAL-PROPERTIES; COMPOSITES; GROWTH; ARRAYS; WIRES; TIPS
AB Vertically aligned carbon nanotube (CNT) forests were synthesized to study their quasi-static mechanical properties in a layered configuration with metallization. The top and bottom surfaces of CNT forests were metalized with Ag, Fe, and In using paste, sputtering, and thermal evaporation, respectively. Stacks of one, two, and three layers of these forests were assembled and compressed to measure their mechanical properties. The samples were strain limited to 0.7, and the results indicate that energy dissipation is approximately linear with respect to the number of layers and relatively independent of metal type. The energy per unit volume was approximately the same for all samples. Successive stacking of CNT forests reduces local buckling events, which is enhanced with a thick Ag deposition on the CNT forest surface. Young's modulus was also observed to increase as the number of layers was increased. These results are useful in the design of composite materials for high energy absorption and high stiffness applications.
C1 [Boddu, Veera M.; Brenner, Matthew W.] US Army Engn Res & Dev Ctr, Construct Engn Res Lab ERDC CERL, Environm Proc Branch, Champaign, IL 61826 USA.
[Boddu, Veera M.] ARS, Plant Polymer Res Unit, Natl Ctr Agr Utilizat Res, USDA, 1815 N Univ St, Peoria, IL 61604 USA.
RP Boddu, VM (reprint author), US Army Engn Res & Dev Ctr, Construct Engn Res Lab ERDC CERL, Environm Proc Branch, Champaign, IL 61826 USA.; Boddu, VM (reprint author), ARS, Plant Polymer Res Unit, Natl Ctr Agr Utilizat Res, USDA, 1815 N Univ St, Peoria, IL 61604 USA.
EM Veera.Boddu@ars.usda.gov
NR 34
TC 0
Z9 0
U1 3
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0947-8396
EI 1432-0630
J9 APPL PHYS A-MATER
JI Appl. Phys. A-Mater. Sci. Process.
PD FEB
PY 2016
VL 122
IS 2
AR 88
DI 10.1007/s00339-015-9571-8
PG 11
WC Materials Science, Multidisciplinary; Physics, Applied
SC Materials Science; Physics
GA DD5OB
UT WOS:000369972400043
ER
PT J
AU Ruff, AL
Beach, S
Lehman, J
Rothwell, C
Dillman, JF
AF Ruff, Albert L.
Beach, Sarah
Lehman, John
Rothwell, Cristin
Dillman, James F.
TI Identification and validation of vesicant therapeutic targets using a
high-throughput siRNA screening approach
SO ARCHIVES OF TOXICOLOGY
LA English
DT Article
DE Sulfur mustard; Cutaneous injury; siRNA; High-throughput screening;
Inflammation; In vitro models
ID SULFUR MUSTARD; GENE-EXPRESSION; NATRIURETIC-PEPTIDE; MICROARRAY
ANALYSIS; HUMAN KERATINOCYTE; ALKYLATING-AGENTS; LESIONS; ROLES; CORIN;
P38
AB Sulfur mustard [SM, bis-(2-chloroethyl) sulfide] is a highly reactive bifunctional alkylating agent that has been used as a vesicating agent in warfare scenarios to induce severe lung, skin, and eye injury. SM cutaneous lesions are characterized by both vesication and severe inflammation, but the molecular mechanisms that lead to these signs and symptoms are not well understood. There is a pressing need for effective therapeutics to treat this injury. An understanding of the molecular mechanisms of injury and identification of potential therapeutic targets is necessary for rational therapeutic development. We have applied a high-throughput small interfering RNA (siRNA) screening approach to the problem of SM cutaneous injury in an effort to meet these needs. Our siRNA screening efforts have initially focused on SM-induced inflammation in cutaneous injury since chronic inflammation after exposure appears to play a role in progressive clinical pathology, and intervention may improve clinical outcome. Also, targets that mitigate cellular injury should reduce the inflammatory response. Historical microarray data on this injury were mined for targets and pathways implicated in inflammation, and a siRNA library of 2,017 targets was assembled for screening. Primary screening and library deconvolution were performed using human HaCaT keratinocytes and focused on cell death and inflammatory markers as end points. Using this in vitro approach, we have identified and validated novel targets for the potential treatment of SM-induced cutaneous injury.
C1 [Ruff, Albert L.; Beach, Sarah; Lehman, John; Rothwell, Cristin; Dillman, James F.] US Army, Med Res Inst Chem Def, Div Res, Cell & Mol Biol Branch, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA.
RP Ruff, AL (reprint author), US Army, Med Res Inst Chem Def, Div Res, Cell & Mol Biol Branch, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA.
EM albert.l.ruff2.civ@mail.mil
FU Defense Threat Reduction Agency-Joint Science and Technology Office,
Medical ST Division [CBM.CUTOC.04.10.RC.001]
FX This research was supported by the Defense Threat Reduction Agency-Joint
Science and Technology Office, Medical S&T Division, Project ID Number
CBM.CUTOC.04.10.RC.001.
NR 24
TC 0
Z9 0
U1 2
U2 5
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0340-5761
EI 1432-0738
J9 ARCH TOXICOL
JI Arch. Toxicol.
PD FEB
PY 2016
VL 90
IS 2
BP 375
EP 383
DI 10.1007/s00204-014-1427-z
PG 9
WC Toxicology
SC Toxicology
GA DD8SD
UT WOS:000370196300012
PM 25537185
ER
PT J
AU Hostler, DC
Marx, ES
Moores, LK
Petteys, SK
Hostler, JM
Mitchell, JD
Holley, PR
Collen, JF
Foster, BE
Holley, AB
AF Hostler, David C.
Marx, Elizabeth S.
Moores, Lisa K.
Petteys, Sarah K.
Hostler, Jordanna Mae
Mitchell, Joshua D.
Holley, Paul R.
Collen, Jacob F.
Foster, Brian E.
Holley, Aaron B.
TI Validation of the International Medical Prevention Registry on Venous
Thromboembolism Bleeding Risk Score
SO CHEST
LA English
DT Article
DE antibiotic therapy; deep venous thrombosis; pulmonary embolism
ID DEEP-VEIN THROMBOSIS; ANTITHROMBOTIC THERAPY; HOSPITALIZED-PATIENTS;
NONSURGICAL PATIENTS; PRACTICE GUIDELINES; PULMONARY-EMBOLISM;
AMERICAN-COLLEGE; PROPHYLAXIS; EPIDEMIOLOGY; PHYSICIANS
AB BACKGROUND: Recent guidelines recommend assessing medical inpatients for bleeding risk prior to providing chemical prophylaxis for VTE. The International Medical Prevention Registry on Venous Thromboembolism (IMPROVE) bleeding risk score (BRS) was derived from a well-defined population of medical inpatients but it has not been validated externally. We sought to externally validate the IMPROVE BRS.
METHODS: We prospectively collected characteristics on admission and VTE prophylaxis data each hospital day for all patients admitted for a medical illness to the Walter Reed Army Medical Center over an 18-month period. We calculated the IMPROVE BRS for each patient using admission data and reviewed medical records to identify bleeding events.
RESULTS: From September 2009 through March 2011, 1,668 inpatients met the IMPROVE inclusion criteria. Bleeding events occurred during 45 separate admissions (2.7%); 31 events (1.9%) were major and 14 (0.8%) were nonmajor but clinically relevant. Two hundred fiftysix patients (20.7%) had an IMPROVE BRS >= 7.0. Kaplan-Meier curves showed a higher cumulative incidence of major (P = .02) and clinically important (major plus clinically relevant nonmajor) (P = .06) bleeding within 14 days in patients with an IMPROVE BRS >= 7.0. An IMPROVE BRS >= 7.0 was associated with major bleeding in Cox-regression analysis adjusted for administration of chemical prophylaxis (OR, 2.6; 95% CI, 1.1-5.9; P = .03); there was a trend toward a significant association with clinically important bleeding (OR, 1.9; 95% CI, 0.9-3.7; P = .07).
CONCLUSIONS: The IMPROVE BRS calculated at admission predicts major bleeding in medical inpatients. This model may help assess the relative risks of bleeding and VTE before chemoprophylaxis is administered.
C1 [Hostler, David C.; Petteys, Sarah K.] Walter Reed Natl Mil Med Ctr, Dept Pulm & Crit Care Med, Bethesda, MD 20889 USA.
[Marx, Elizabeth S.] Walter Reed Natl Mil Med Ctr, Dept Pediat, Bethesda, MD 20889 USA.
[Hostler, Jordanna Mae; Holley, Aaron B.] Walter Reed Natl Mil Med Ctr, Dept Pulm Crit Care & Sleep Med, 8901 Wisconsin Ave, Bethesda, MD 20889 USA.
[Mitchell, Joshua D.; Foster, Brian E.] Walter Reed Natl Mil Med Ctr, Dept Internal Med, Bethesda, MD 20889 USA.
[Moores, Lisa K.] Uniformed Serv Univ Hlth Sci, Dept Med, Room A3060, Bethesda, MD 20814 USA.
[Holley, Paul R.] US Army, Med Res Inst Infect Dis, Dept Informat, Frederick, MD USA.
[Collen, Jacob F.] San Antonio Mil Med Ctr, Dept Pulm & Crit Care Med, San Antonio, TX USA.
RP Holley, AB (reprint author), Walter Reed Natl Mil Med Ctr, Dept Pulm Crit Care & Sleep Med, 8901 Wisconsin Ave, Bethesda, MD 20889 USA.
EM aholley9@gmail.com
NR 28
TC 2
Z9 2
U1 0
U2 3
PU AMER COLL CHEST PHYSICIANS
PI GLENVIEW
PA 2595 PATRIOT BLVD, GLENVIEW, IL 60026 USA
SN 0012-3692
J9 CHEST
JI Chest
PD FEB
PY 2016
VL 149
IS 2
BP 372
EP 379
DI 10.1378/chest.14-2842
PG 8
WC Critical Care Medicine; Respiratory System
SC General & Internal Medicine; Respiratory System
GA DD1DC
UT WOS:000369660400020
PM 26867833
ER
PT J
AU Lettieri, CJ
Williams, SG
Collen, JF
AF Lettieri, Christopher J.
Williams, Scott G.
Collen, Jacob F.
TI OSA Syndrome and Posttraumatic Stress Disorder Clinical Outcomes and
Impact of Positive Airway Pressure Therapy
SO CHEST
LA English
DT Article
DE continuous positive airway pressure; CPAP adherence; obstructive sleep
apnea; posttraumatic stress disorder; quality of life
ID OBSTRUCTIVE SLEEP-APNEA; QUALITY-OF-LIFE; TRAUMATIC BRAIN-INJURY; CPAP
USE; DAYTIME SLEEPINESS; MILITARY PERSONNEL; FUNCTIONAL STATUS;
ADHERENCE; INSOMNIA; NIGHTMARES
AB BACKGROUND: We sought to determine the impact of OSA syndrome (OSAS) on symptoms and quality of life (QoL) among patients with posttraumatic stress disorder (PTSD). In addition, we assessed adherence and response to positive airway pressure (PAP) therapy in this population.
METHODS: This was a case-controlled observational cohort study at the Sleep Disorders Center of an academic military medical center. Two hundred consecutive patients with PTSD underwent sleep evaluations. Patients with PTSD with and without OSAS were compared with 50 consecutive age-matched patients with OSAS without PTSD and 50 age-matched normal control subjects. Polysomnographic data, sleep-related symptoms and QoL measures, and objective PAP usage were obtained.
RESULTS: Among patients with PTSD, more than one-half (56.6%) received a diagnosis of OSAS. Patients with PTSD and OSAS had lower QoL and more somnolence compared with the other groups. Patients with PTSD demonstrated significantly lower adherence and response to PAP therapy. Resolution of sleepiness occurred in 82% of patients with OSAS alone, compared with 62.5% of PAP-adherent and 21.4% of nonadherent patients with PTSD and OSAS (P < .001). Similarly, posttreatment Functional Outcomes of Sleep Questionnaire >= 17.9 was achieved in 72% of patients with OSAS, compared with only 56.3% of patients with PTSD and OSA who were PAP adherent and 26.2% who were nonadherent (P < .03).
CONCLUSIONS: In patients with PTSD, comorbid OSAS is associated with worsened symptoms, QoL, and adherence and response to PAP. Given the negative impact on outcomes, the possibility of OSAS should be considered carefully in patients with PTSD. Close follow-up is needed to optimize PAP adherence and efficacy in this at-risk population.
C1 [Lettieri, Christopher J.; Williams, Scott G.; Collen, Jacob F.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD USA.
[Lettieri, Christopher J.] Walter Reed Natl Mil Med Ctr, Dept Pulm Crit Care & Sleep Med, Bethesda, MD USA.
[Williams, Scott G.] Womack Army Med Ctr, Dept Pulm Crit Care & Sleep Med, Ft Bragg, NC USA.
[Collen, Jacob F.] Brooke Army Med Ctr, Dept Pulm Crit Care & Sleep Med, Ft Sam Houston, TX 78234 USA.
RP Collen, JF (reprint author), Brooke Army Med Ctr, Pulm Crit Care & Sleep Med, San Antonio Mil Med Ctr, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM jacob.f.collen.mil@mail.mil
NR 57
TC 5
Z9 5
U1 1
U2 2
PU AMER COLL CHEST PHYSICIANS
PI GLENVIEW
PA 2595 PATRIOT BLVD, GLENVIEW, IL 60026 USA
SN 0012-3692
J9 CHEST
JI Chest
PD FEB
PY 2016
VL 149
IS 2
BP 483
EP 490
DI 10.1378/chest.15-0693
PG 8
WC Critical Care Medicine; Respiratory System
SC General & Internal Medicine; Respiratory System
GA DD1DC
UT WOS:000369660400031
PM 26291560
ER
PT J
AU Briant, LJB
Charkoudian, N
Hart, EC
AF Briant, L. J. B.
Charkoudian, N.
Hart, E. C.
TI Sympathetic regulation of blood pressure in normotension and
hypertension: when sex matters
SO EXPERIMENTAL PHYSIOLOGY
LA English
DT Article
ID RENIN-ANGIOTENSIN SYSTEM; POINT CHRONIC ACTIVATION; ALL-CAUSE MORTALITY;
NERVE ACTIVITY; DOMINANT CONTRIBUTOR; ARTERIAL STIFFNESS; POSTMENOPAUSAL
WOMEN; AUTONOMIC SUPPORT; COUNTERPOINT ACTIVATION; CARDIOVASCULAR EVENTS
AB New Findings What is the topic of this review? Hypertension is a major problem in Western society. Risk of hypertension increases with age, especially in women, who have lower risk compared with men until menopause. This review outlines the sex differences in the sympathetic control of blood pressure and how these mechanisms change with age. What advances does it highlight? It has recently been recognized that men and women regulate blood pressure by different physiological mechanisms. This is important for both the understanding and the clinical management of individual patients with hypertension. This review summarizes recent advances in understanding how the regulation of blood pressure in hypertension by the sympathetic nervous system differs between men and women.
The sympathetic nervous system has a central role in the regulation of arterial blood pressure (BP) and in the development of hypertension in humans. Recent evidence points to differences between the sexes in the integrative mechanisms by which BP is controlled, suggesting that the development of hypertension may follow distinct pathways in women compared with men. An important aspect of sympathetic control of BP is its substantial interindividual variability. In healthy young men, the variability in sympathetic nerve activity (SNA) is balanced by variability in cardiac output and vascular adrenergic responses, such that BP remains similar, and normal, across a severalfold range of resting SNA values. In young women, variability in resting SNA is similar to that seen in men, but the balancing' mechanisms are strikingly different; women exhibit greater -adrenergic vasodilatation compared with men, which minimizes the pressor effects of a given level of SNA. Ageing is associated with increased SNA and a loss of the balancing factors seen in younger people, leading to an increased risk of hypertension in older people. Loss of oestrogen with menopause in women appears to be linked mechanistically with the decrease in -adrenergic vasodilatation and the increased risk of hypertension in older women. Other important factors contributing to hypertension via sympathetic mechanisms are obesity and arterial stiffening, both of which increase with ageing. We conclude with a discussion of important areas in which more work is needed to understand and manage appropriately the sex-specific mechanisms in the development and maintenance of hypertension.
C1 [Briant, L. J. B.; Hart, E. C.] Univ Bristol, Clin Res & Imaging Ctr, Cardion Grp, Bristol, Avon, England.
[Charkoudian, N.] US Army, Environm Med Res Inst, Natick, MA 01760 USA.
RP Hart, EC (reprint author), Univ Bristol, Clin Res & Imaging Ctr, Cardion Grp, Bristol, Avon, England.; Hart, EC (reprint author), CardioN Res Grp, Med Sci Bldg, Bristol BS8 1TD, Avon, England.
EM emma.hart@bristol.ac.uk
FU British Heart Foundation [FS/11/1/28400]
NR 95
TC 3
Z9 3
U1 3
U2 11
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0958-0670
EI 1469-445X
J9 EXP PHYSIOL
JI Exp. Physiol.
PD FEB 1
PY 2016
VL 101
IS 2
BP 219
EP 229
DI 10.1113/EP085368
PG 11
WC Physiology
SC Physiology
GA DD3ZU
UT WOS:000369862900003
PM 26682826
ER
PT J
AU Ryan, LTCPM
Rodriguez, MAJRM
AF Ryan, L. T. C. Paul M.
Rodriguez, M. A. J. Ryan M.
TI Outcomes and Return to Activity After Operative Repair of Chronic Latent
Syndesmotic Instability
SO FOOT & ANKLE INTERNATIONAL
LA English
DT Article
DE arthritis; biomechanics; sports; trauma; outcome studies
ID DISTAL TIBIOFIBULAR SYNDESMOSIS; RADIOGRAPHIC EVALUATION; ANKLE
SYNDESMOSIS; DIAGNOSIS; ARTHROSCOPY; FIXATION; FRACTURE; SPRAINS
AB Background: This study is a retrospective review of prospectively gathered data determining the postoperative outcomes of patients who underwent operative treatment to address chronic syndesmotic instability.
Methods: The cohort is composed of 19 individuals who elected to undergo operative treatment of chronic syndesmotic instability. The operative repair consisted of arthroscopic debridement in all cases with reduction and suture button fixation of those patients who had greater than 4 mm of syndesmotic diastasis on arthroscopic evaluation. All patients had a minimum of 24 months follow-up. This study retrospectively examined the prospectively gathered preoperative and postoperative outcome scores to include a Visual Analog Scale (VAS) pain score and an American Orthopaedic Foot & Ankle Society (AOFAS) ankle-hindfoot score. In addition, patients were questioned on their ability to return to their preinjury level of activity and their ability to continue running sports. Fourteen patients returned their postoperative surveys.
Results: Mean AOFAS scores improved significantly from 48 to 82.7 (P = .014). Mean VAS scores improved from 6.1 to 1.0 (P = .002). Overall, 86% (12/14) of patients were able to return to running and 79% (11/14) of patients were able to return to their preinjury level of sport. Preoperative and postoperative weight-bearing ankle radiographs were reviewed to evaluate the tibiofibular clear space and overlap. The clear space measured on anteroposterior (AP) radiographs decreased from 5.4 mm to 4.6 mm (P = .005), the clear space evaluated on the mortise radiograph decreased from 4.5 mm to 3.6 mm (P = .006), and the overlap measured on the AP radiograph increased from 5.7 mm to 6.9 mm (P = .019). All radiographs were measured by a board-certified musculoskeletal radiologist.
Conclusion: This study presents a treatment method that can be instituted at the time of diagnosis for syndesmotic injuries with greater than 4 mm of diastasis that were treated with debridement and stabilization. The results of this treatment technique are promising, with significant improvements in subjective outcome scores and a high rate of return to running sports.
Level of Evidence: Level IV, retrospective case series.
C1 [Ryan, L. T. C. Paul M.] Orthopaed Clin, Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
[Rodriguez, M. A. J. Ryan M.] Orthopaed Clin, Madigan Army Med Ctr, Tacoma, WA USA.
RP Ryan, LTCPM (reprint author), Orthopaed Clin, Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM paul.m.ryan.mil@mail.mil
NR 24
TC 2
Z9 2
U1 1
U2 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1071-1007
EI 1944-7876
J9 FOOT ANKLE INT
JI Foot Ankle Int.
PD FEB
PY 2016
VL 37
IS 2
BP 192
EP 197
DI 10.1177/1071100715606488
PG 6
WC Orthopedics
SC Orthopedics
GA DD5KD
UT WOS:000369961600010
ER
PT J
AU Chou, R
Gordon, DB
de Leon-Casasola, OA
Rosenberg, JM
Bickler, S
Brennan, T
Carter, T
Cassidy, CL
Chittenden, EH
Degenhardt, E
Griffith, S
Manworren, R
McCarberg, B
Montgomery, R
Murphy, J
Perkal, MF
Suresh, S
Sluka, K
Strassels, S
Thirlby, R
Viscusi, E
Walco, GA
Warner, L
Weisman, SJ
Wu, CL
AF Chou, Roger
Gordon, Debra B.
de Leon-Casasola, Oscar A.
Rosenberg, Jack M.
Bickler, Stephen
Brennan, Tim
Carter, Todd
Cassidy, Carla L.
Chittenden, Eva Hall
Degenhardt, Ernest
Griffith, Scott
Manworren, Renee
McCarberg, Bill
Montgomery, Robert
Murphy, Jamie
Perkal, Melissa F.
Suresh, Santhanam
Sluka, Kathleen
Strassels, Scott
Thirlby, Richard
Viscusi, Eugene
Walco, Gary A.
Warner, Lisa
Weisman, Steven J.
Wu, Christopher L.
TI Management of Postoperative Pain: A Clinical Practice Guideline From the
American Pain Society, the American Society of Regional Anesthesia and
Pain Medicine, and the American Society of Anesthesiologists' Committee
on Regional Anesthesia, Executive Committee, and Administrative Council
SO JOURNAL OF PAIN
LA English
DT Article
DE Postoperative pain management; clinical practice guidelines; analgesia;
education; multi-modal therapy; patient assessment; regional analgesia;
neuraxial analgesia
ID TOTAL KNEE ARTHROPLASTY; CRUCIATE LIGAMENT RECONSTRUCTION;
PATIENT-CONTROLLED ANALGESIA; RANDOMIZED CONTROLLED-TRIAL; ELECTRICAL
NERVE-STIMULATION; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; INTRAARTICULAR
BUPIVACAINE INFUSION; PERSISTENT POSTSURGICAL PAIN; LIDOCAINE-PRILOCAINE
CREAM; PLACEBO-CONTROLLED TRIAL
AB Most patients who undergo surgical procedures experience acute postoperative pain, but evidence suggests that less than half report adequate postoperative pain relief. Many preoperative, intra-operative, and postoperative interventions and management strategies are available for reducing and managing postoperative pain. The American Pain Society, with input from the American Society of Anesthesiologists, commissioned an interdisciplinary expert panel to develop a clinical practice guideline to promote evidence-based, effective, and safer postoperative pain management in children and adults. The guideline was subsequently approved by the American Society for Regional Anesthesia. As part of the guideline development process, a systematic review was commissioned on various aspects related to various interventions and management strategies for postoperative pain. After a review of the evidence, the expert panel formulated recommendations that addressed various aspects of postoperative pain management, including preoperative education, perioperative pain management planning, use of different pharmacological and nonpharmacological modalities, organizational policies, and transition to outpatient care. The recommendations are based on the underlying premise that optimal management begins in the preoperative period with an assessment of the patient and development of a plan of care tailored to the individual and the surgical procedure involved. The panel found that evidence supports the use of multimodal regimens in many situations, although the exact components of effective multi modal care will vary depending on the patient, setting, and surgical procedure. Although these guidelines are based on a systematic review of the evidence on management of postoperative pain, the panel identified numerous research gaps. Of 32 recommendations, 4 were assessed as being supported by high-quality evidence, and 11 (in the areas of patient education and perioperative planning, patient assessment, organizational structures and policies, and transitioning to outpatient care) were made on the basis of low-quality evidence. (C) 2016 by the American Pain Society
C1 [Chou, Roger] Oregon Hlth & Sci Univ, Pacific Northwest Evidence Based Practice Ctr, Dept Med, Portland, OR 97201 USA.
[Chou, Roger] Oregon Hlth & Sci Univ, Pacific Northwest Evidence Based Practice Ctr, Dept Med Informat & Clin Epidemiol, Portland, OR 97201 USA.
[Gordon, Debra B.] Univ Washington, Dept Anesthesiol & Pain Med, Seattle, WA 98195 USA.
[de Leon-Casasola, Oscar A.] Roswell Pk Canc Inst, Dept Anesthesiol & Pain Med, Buffalo, NY 14263 USA.
[de Leon-Casasola, Oscar A.] SUNY Buffalo, Sch Med & Biomed Sci, Buffalo, NY 14260 USA.
[Rosenberg, Jack M.] Univ Michigan, Vet Integrated Serv Network, Dept Vet Affairs, Ann Arbor, MI 48109 USA.
[Rosenberg, Jack M.] Univ Michigan, Dept Phys Med, Ann Arbor, MI 48109 USA.
[Rosenberg, Jack M.] Univ Michigan, Dept Rehabil & Anesthesiol, Ann Arbor, MI 48109 USA.
[Bickler, Stephen] Univ Calif San Diego, Pediat Surg, San Diego, CA 92103 USA.
[Brennan, Tim] Univ Iowa Hosp & Clin, Dept Anesthesia, Iowa City, IA 52242 USA.
[Carter, Todd] Univ Cincinnati, Dept Anesthesia, Cincinnati, OH USA.
[Cassidy, Carla L.] Vet Hlth Adm, Dept Vet Affairs, Washington, DC USA.
[Chittenden, Eva Hall] Massachusetts Gen Hosp, Dept Palliat Care, Boston, MA 02114 USA.
[Degenhardt, Ernest] United States Army Med Command, Qual Management Div, San Antonio, TX USA.
[Griffith, Scott] Walter Reed Army Med Ctr, Crit Care Med, Bethesda, MD USA.
[Manworren, Renee] Univ Connecticut, Sch Med, Dept Pediat, Mansfield, CT USA.
[McCarberg, Bill] Amer Acad Pain Med, San Diego, CA USA.
[Montgomery, Robert] Univ Colorado, Dept Anesthesiol, Denver, CO 80202 USA.
[Murphy, Jamie; Wu, Christopher L.] Johns Hopkins Univ, Dept Anesthesiol & Crit Care Med, Baltimore, MD USA.
[Perkal, Melissa F.] Vet Affairs Med Ctr, Dept Surg, West Haven, CT USA.
[Suresh, Santhanam] Childrens Hosp Chicago, Dept Pediat Anesthesia, Chicago, IL USA.
[Sluka, Kathleen] Univ Iowa, Dept Phys Therapy & Rehabil, Iowa City, IA USA.
[Strassels, Scott] Univ Texas Austin, Coll Pharm, Austin, TX 78712 USA.
[Thirlby, Richard] Virginia Mason Med Ctr, Bariatr Weight Loss Surg Ctr, Seattle, WA 98101 USA.
[Viscusi, Eugene] Thomas Jefferson Univ, Dept Anesthesiol, Philadelphia, PA 19107 USA.
[Walco, Gary A.] Seattle Childrens Hosp, Dept Anesthesiol & Pain Med, Seattle, WA USA.
[Warner, Lisa] Dept Veteran Affairs, Phoenix, AZ USA.
[Weisman, Steven J.] Childrens Hosp Wisconsin, Dept Anesthesiol, Wauwatosa, WI USA.
RP Chou, R (reprint author), 3181 SW Sam Jackson Pk Rd,Mail Code BICC, Portland, OR 97239 USA.
EM chour@ohsu.edu
FU American Pain Society
FX Funding for this guideline was provided by the American Pain Society.
The guideline was submitted for approval by the partnering
organizations, but the content of the guideline is the sole
responsibility of the authors and panel members.
NR 320
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U2 27
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 1526-5900
J9 J PAIN
JI J. Pain
PD FEB
PY 2016
VL 17
IS 2
BP 131
EP 157
DI 10.1016/j.jpain.2015.12.008
PG 27
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA DD7NO
UT WOS:000370111600001
PM 26827847
ER
PT J
AU Nagai, T
Clark, NC
Abt, JP
Sell, TC
Heebner, NR
Smalley, BW
Wirt, MD
Lephart, SM
AF Nagai, Takashi
Clark, Nicholas C.
Abt, John P.
Sell, Timothy C.
Heebner, Nicholas R.
Smalley, Brian W.
Wirt, Michael D.
Lephart, Scott M.
TI The Effect of Target Position on the Accuracy of Cervical-Spine-Rotation
Active Joint-Position Sense
SO JOURNAL OF SPORT REHABILITATION
LA English
DT Article
DE proprioception; neck; helicopter pilots
ID CERVICOCEPHALIC KINESTHETIC SENSIBILITY; NECK PAIN; SENSORIMOTOR SYSTEM;
WHIPLASH INJURY; MUSCLE-SPINDLES; MOTION; MANAGEMENT; RANGE; HEAD;
PROPRIOCEPTION
AB Context: The cervical spine can be divided into upper and lower units, each making a different contribution to the magnitude of rotation and proprioception. However, few studies have examined the effect of the cervical rotation positions on proprioception. Objective: To compare cervical-spine rotation active joint-position sense (AJPS) near midrange of motion (mid-ROM; 30 degrees) and near end-ROM (60 degrees). Design: Cross-sectional study. Setting: Human performance research laboratory. Participants: 53 military helicopter pilots (age 28.4 +/- 6.2 y, height 175.3 +/- 9.3 cm, weight 80.1 +/- 11.8 kg). Main Outcome Measures: A motion-analysis system was used to record cervical-rotation kinematics. Subjects sat in a chair wearing a headband and blindfold. First, they actively rotated the head right or left to a target position (30 degrees/60 degrees), with real-time verbal cues provided by the tester. Subjects held the target position for 5 s and then returned to the start position. After this, they replicated the target position as closely as possible. Five trials were performed in both directions to both target positions (R30/R60/L30/L60). Order of direction/position was randomized. The difference between target and replicated positions was calculated and defined as absolute error (AE), and the mean of 5 trials was used for analyses. Wilcoxon signed-ranks tests were used to compare AJPS at the different target positions (P <.0125 with Bonferroni adjustments). Results: End-ROM AEs were significantly more accurate than mid-ROM AEs (P =.001). Conclusion: Cervical-spine-rotation AJPS is more accurate near end-ROM than mid-ROM. Both target positions should be used to examine cervical-spine-rotation AJPS of both the upper and lower units.
C1 [Nagai, Takashi] Univ Pittsburgh, Dept Sports Med & Nutr, Pittsburgh, PA USA.
[Clark, Nicholas C.] St Marys Univ, Sch Sport Hlth & Appl Sci, London, England.
[Abt, John P.; Heebner, Nicholas R.; Lephart, Scott M.] Univ Kentucky, Coll Hlth Sci, Lexington, KY USA.
[Sell, Timothy C.] Duke Univ, Dept Orthopaed Surg, Durham, NC USA.
[Smalley, Brian W.] US Army Aeromed Act, Ft Rucker, AL USA.
[Wirt, Michael D.] US Army Inst Surg Res, Ft Sam Houston, TX USA.
RP Nagai, T (reprint author), Univ Pittsburgh, Dept Sports Med & Nutr, Pittsburgh, PA USA.
EM tnagai@pitt.edu
FU US Army Medical Research and Materiel Command [W81XWH-11-2-0097]
FX This work was supported by the US Army Medical Research and Materiel
Command under Award No. W81XWH-11-2-0097. Opinions, interpretations,
conclusions, and recommendations are those of the author and are not
necessarily endorsed by the US Army.
NR 48
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U1 1
U2 6
PU HUMAN KINETICS PUBL INC
PI CHAMPAIGN
PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA
SN 1056-6716
EI 1543-3072
J9 J SPORT REHABIL
JI J. Sport Rehabil.
PD FEB
PY 2016
VL 25
IS 1
BP 58
EP 63
DI 10.1123/jsr.2014-0263
PG 6
WC Rehabilitation; Sport Sciences
SC Rehabilitation; Sport Sciences
GA DD7OY
UT WOS:000370115200009
PM 26836358
ER
PT J
AU Tavakoly, AA
Maidment, DR
McClelland, JW
Whiteaker, T
Yang, ZL
Griffin, C
David, CH
Meyer, L
AF Tavakoly, Ahmad A.
Maidment, David R.
McClelland, James W.
Whiteaker, Tim
Yang, Zong-Liang
Griffin, Claire
David, Cedric H.
Meyer, Lisa
TI A GIS FRAMEWORK FOR REGIONAL MODELING OF RIVERINE NITROGEN TRANSPORT:
CASE STUDY, SAN ANTONIO AND GUADALUPE BASINS
SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION
LA English
DT Article
DE total nitrogen; geographic information system; river networks; nonpoint
source pollution; surface water hydrology; NHDPlus; Routing Application
for Parallel computation of Discharge
ID LAND-USE CHANGE; GULF-OF-MEXICO; WATER-QUALITY; NORTHEASTERN USA;
UNITED-STATES; EXPORT; STREAMS; FLOW; NUTRIENTS; NETWORKS
AB This article presents a framework for integrating a regional geographic information system (GIS)-based nitrogen dataset (Texas Anthropogenic Nitrogen Dataset, TX-ANB) and a GIS-based river routing model (Routing Application for Parallel computation of Discharge) to simulate steady-state riverine total nitrogen (TN) transport in river networks containing thousands of reaches. A two-year case study was conducted in the San Antonio and Guadalupe basins during dry and wet years (2008 and 2009, respectively). This article investigates TN export in urbanized (San Antonio) vs. rural (Guadalupe) drainage basins and considers the effect of reservoirs on TN transport. Simulated TN export values are within 10 percent of measured export values for selected stations in 2008 and 2009. Results show that in both years the San Antonio basin contributed a larger quantity than the Guadalupe basin of delivered TN to the coastal ocean. The San Antonio basin is affected by urban activities including point sources, associated with the city of San Antonio, in addition to greater agricultural activities. The Guadalupe basin lacks major metropolitan areas and is dominated by rangeland, rather than fertilized agricultural fields. Both basins delivered more TN to coastal waters in 2009 than in 2008. Furthermore, TN removal in the San Antonio and Guadalupe basins is inversely related to stream orders: the higher the order the more TN delivery (or the less TN removal).
C1 [Tavakoly, Ahmad A.] US Army, Corps Engineers, Coastal & Hydraul Lab, River Engn Branch, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
[Maidment, David R.] Univ Texas Austin, Dept Civil Architectural & Environm Engn, Austin, TX 78712 USA.
[Whiteaker, Tim] Univ Texas Austin, Ctr Res Water Resources, Austin, TX 78712 USA.
[Yang, Zong-Liang] Univ Texas Austin, Jackson Sch Geosci, Austin, TX 78712 USA.
[McClelland, James W.; Griffin, Claire] Univ Texas Austin, Dept Marine Sci, Port Aransas, TX 78373 USA.
[David, Cedric H.] CALTECH, Jet Prop Lab, 4800 Oak Grove Dr, Pasadena, CA 91109 USA.
[Meyer, Lisa] Hilcorp Energy Co, Houston, TX 77002 USA.
RP Tavakoly, AA (reprint author), US Army, Corps Engineers, Coastal & Hydraul Lab, River Engn Branch, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM ahmad.a.tavakoly@erdc.dren.mil
RI Yang, Zong-Liang/B-4916-2011; McClelland, James/C-5396-2008;
OI McClelland, James/0000-0001-9619-8194; Tavakoly, Ahmad
A./0000-0002-2163-2627
FU NASA Interdisciplinary Science Project [NNX11AE42G]; USACE Coastal and
Hydraulics Laboratory; Jet Propulsion Laboratory; California Institute
of Technology
FX This project was partially funded by the NASA Interdisciplinary Science
Project NNX11AE42G and USACE Coastal and Hydraulics Laboratory. The
locations and data on wastewater treatment plants and industrial
facilities were obtained from the Discharge Monitoring Report (DMR)
Pollutant Loading Tool. The river maps were derived from the NHDPlus
dataset. Cedric H. David is supported by the Jet Propulsion Laboratory,
California Institute of Technology, under a contract with the National
Aeronautics and Space Administration. We thank the editor-in-chief and
two anonymous reviewers for their valuable comments that helped improved
the original version of this manuscript.
NR 51
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U2 13
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1093-474X
EI 1752-1688
J9 J AM WATER RESOUR AS
JI J. Am. Water Resour. Assoc.
PD FEB
PY 2016
VL 52
IS 1
BP 1
EP 15
DI 10.1111/1752-1688.12355
PG 15
WC Engineering, Environmental; Geosciences, Multidisciplinary; Water
Resources
SC Engineering; Geology; Water Resources
GA DD5XV
UT WOS:000369999100001
ER
PT J
AU Hendrickx, JMH
Allen, RG
Brower, A
Byrd, AR
Hong, SH
Ogden, FL
Pradhan, NR
Robison, CW
Toll, D
Trezza, R
Umstot, TG
Wilson, JL
AF Hendrickx, Jan M. H.
Allen, Richard G.
Brower, Al
Byrd, Aaron R.
Hong, Sung-ho
Ogden, Fred L.
Pradhan, Nawa Raj
Robison, Clarence W.
Toll, David
Trezza, Ricardo
Umstot, Todd G.
Wilson, John L.
TI BENCHMARKING OPTICAL/THERMAL SATELLITE IMAGERY FOR ESTIMATING
EVAPOTRANSPIRATION AND SOIL MOISTURE IN DECISION SUPPORT TOOLS
SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION
LA English
DT Article
DE soil moisture; evapotranspiration; GSSHA; SEBAL; METRIC; DPWM;
distributed hydrologic modeling; optical/thermal satellite imagery;
Landsat; MODIS; groundwater recharge; water management; hydrograph
ID ENERGY BALANCE ALGORITHM; CROP COEFFICIENT METHOD; LATENT-HEAT FLUXES;
ROOT WATER-UPTAKE; OPTICAL IMAGERY; MAPPING EVAPOTRANSPIRATION;
ESTIMATING EVAPORATION; MODEL; SURFACE; LAND
AB Generally, one expects evapotranspiration (ET) maps derived from optical/thermal Landsat and MODIS satellite imagery to improve decision support tools and lead to superior decisions regarding water resources management. However, there is lack of supportive evidence to accept or reject this expectation. We benchmark three existing hydrologic decision support tools with the following benchmarks: annual ET for the ET Toolbox developed by the United States Bureau of Reclamation, predicted rainfall-runoff hydrographs for the Gridded Surface/Subsurface Hydrologic Analysis model developed by the U.S. Army Corps of Engineers, and the average annual groundwater recharge for the Distributed Parameter Watershed Model used by Daniel B. Stephens & Associates. The conclusion of this benchmark study is that the use of NASA/USGS optical/thermal satellite imagery can considerably improve hydrologic decision support tools compared to their traditional implementations. The benefits of improved decision making, resulting from more accurate results of hydrologic support systems using optical/thermal satellite imagery, should substantially exceed the costs for acquiring such imagery and implementing the remote sensing algorithms. In fact, the value of reduced error in estimating average annual groundwater recharge in the San Gabriel Mountains, California alone, in terms of value of water, may be as large as $1 billion, more than sufficient to pay for one new Landsat satellite.
C1 [Hendrickx, Jan M. H.; Wilson, John L.] New Mexico Inst Min & Technol, Dept Earth & Environm Sci, 801 Leroy Pl, Socorro, NM 87801 USA.
[Allen, Richard G.; Robison, Clarence W.; Trezza, Ricardo] Univ Idaho, Kimberly Res & Extens Ctr, Kimberly, ID 83341 USA.
[Brower, Al] US Bur Reclamat, Water & Environm Resources Div, Denver, CO 80225 USA.
[Byrd, Aaron R.; Pradhan, Nawa Raj] US Army, Corps Engineers, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Hong, Sung-ho] Murray State Univ, Dept Geosci, Murray, KY 42071 USA.
[Ogden, Fred L.] Univ Wyoming, Water Resources Environm Sci & Engn, Laramie, WY 82071 USA.
[Toll, David] NASA, Goddard Space Flight Ctr, Hydrol Sci Lab, Greenbelt, MD 20771 USA.
[Umstot, Todd G.] Daniel B Stephens & Associates Inc, Albuquerque, NM 87109 USA.
RP Hendrickx, JMH (reprint author), New Mexico Inst Min & Technol, Dept Earth & Environm Sci, 801 Leroy Pl, Socorro, NM 87801 USA.
EM hendrick@nmt.edu
FU NASA [NNA06CN01A]; Idaho Agricultural Experiment Station
FX We acknowledge financial support by NASA under Cooperative Agreement
#NNA06CN01A, support by the Idaho Agricultural Experiment Station, and
support by the USGS Landsat Science Team (Allen).
NR 152
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U2 18
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1093-474X
EI 1752-1688
J9 J AM WATER RESOUR AS
JI J. Am. Water Resour. Assoc.
PD FEB
PY 2016
VL 52
IS 1
BP 89
EP 119
DI 10.1111/1752-1688.12371
PG 31
WC Engineering, Environmental; Geosciences, Multidisciplinary; Water
Resources
SC Engineering; Geology; Water Resources
GA DD5XV
UT WOS:000369999100007
ER
PT J
AU Aboudara, M
Hicks, B
Cuadrado, D
Mahoney, PF
Docekal, J
AF Aboudara, Matthew
Hicks, B.
Cuadrado, D.
Mahoney, P. F.
Docekal, J.
TI Impact of primary blast lung injury during combat operations in
Afghanistan
SO JOURNAL OF THE ROYAL ARMY MEDICAL CORPS
LA English
DT Letter
C1 [Aboudara, Matthew] Tripler Army Med Ctr, Pulm Clin, MCHK DM P, Jarrett White Rd, Honolulu, HI 96859 USA.
[Hicks, B.] William Beaumont Army Med Ctr, Dept Radiol, El Paso, TX 79920 USA.
[Cuadrado, D.] Madigan Army Med Ctr, Dept Cardiothorac Surg, Tacoma, WA 98431 USA.
[Mahoney, P. F.] Royal Ctr Def Med, Dept Mil Anaesthesia & Crit Care, Birmingham, W Midlands, England.
[Docekal, J.] Tripler Army Med Ctr, Dept Internal Med, Honolulu, HI 96859 USA.
RP Aboudara, M (reprint author), Tripler Army Med Ctr, Pulm Clin, MCHK DM P, Jarrett White Rd, Honolulu, HI 96859 USA.
EM maboudara23@gmail.com
NR 2
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U1 1
U2 3
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0035-8665
EI 2052-0468
J9 J ROY ARMY MED CORPS
JI J. R. Army Med. Corps
PD FEB
PY 2016
VL 162
IS 1
BP 75
EP 75
DI 10.1136/jramc-2015-000481
PG 1
WC Medicine, General & Internal
SC General & Internal Medicine
GA DD6BV
UT WOS:000370009600017
PM 26092970
ER
PT J
AU Tolisano, AM
Song, SJA
Cable, BB
AF Tolisano, Anthony M.
Song, Sungjin A.
Cable, Benjamin B.
TI Author Self-Citation in the Otolaryngology Literature: A Pilot Study
SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY
LA English
DT Article
DE citation analysis; impact factor; h-index
ID OTORHINOLARYNGOLOGY JOURNALS; H-INDEX; IMPACT; OUTPUT
AB Objective To determine the prevalence of author self-citation in the field of otolaryngology.
Study Design and Setting A retrospective review of bibliographic references in 5 otolaryngology journals.
Subjects and Methods Five high-impact otolaryngology journals were reviewed over a 3-month period between January and March 2014 to identify the pattern of author self-citations. Data included study type, otolaryngology topic, authorship, total citations, author self-citations, and country of origin.
Results Nearly two-thirds of articles contained at least 1 self-citation, with an average of 2.6 self-citations per article. Self-citations represented nearly 10% of total citations. Articles with at least 1 self-citation had more authors (5.8 vs 4.9, P < .01) and more citations (30.4 vs 22.2, P < .01) per article than did those without self-citations. There was no difference in self-citation practices between articles originating within the United States and abroad (P = .65). Last authors were the most frequent self-citers and were more likely than lead authors to cite themselves (P < .01). Original reports contained the highest percentage of self-citations per article as compared with reviews and case reports (P < .01).
Conclusion Author self-citation in the otolaryngology literature is common and compares similarly to other medical specialties previously studied. Self-citation should not be considered inappropriate, as it is often done to expand on earlier research. Nevertheless, editors, researchers, and readers should be aware of this increasingly recognized phenomenon and its associated potential implications to the process of scientific inquiry.
C1 [Tolisano, Anthony M.; Song, Sungjin A.; Cable, Benjamin B.] Tripler Army Med Ctr, Dept Otolaryngol, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
RP Tolisano, AM (reprint author), Tripler Army Med Ctr, Dept Otolaryngol, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM anthony.m.tolisano.mil@mail.mil
NR 17
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U1 2
U2 2
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0194-5998
EI 1097-6817
J9 OTOLARYNG HEAD NECK
JI Otolaryngol. Head Neck Surg.
PD FEB
PY 2016
VL 154
IS 2
BP 282
EP 286
DI 10.1177/0194599815616111
PG 5
WC Otorhinolaryngology; Surgery
SC Otorhinolaryngology; Surgery
GA DD5VB
UT WOS:000369991600014
PM 26556466
ER
PT J
AU Cardenas, JC
Cap, AP
Swartz, MD
Huby, MD
Baer, LA
Matijevic, N
Cotton, BA
Holcomb, JB
Wade, CE
AF Cardenas, Jessica C.
Cap, Andrew P.
Swartz, Michael D.
Huby, Maria del Pilar
Baer, Lisa A.
Matijevic, Nena
Cotton, Bryan A.
Holcomb, John B.
Wade, Charles E.
TI PLASMA RESUSCITATION PROMOTES COAGULATION HOMEOSTASIS FOLLOWING
SHOCK-INDUCED HYPERCOAGULABILITY
SO SHOCK
LA English
DT Article
DE Antithrombin; hemorrhagic shock; hemostasis; resuscitation; thrombin;
trauma
ID DAMAGE CONTROL RESUSCITATION; FRESH-FROZEN PLASMA; THROMBIN GENERATION;
HEMORRHAGIC-SHOCK; IN-VITRO; HEMODILUTION; TRANSFUSION; TRAUMA;
HEMOSTASIS; COAGULOPATHY
AB Background:Increased thrombin generation in injured patients possibly contributes to early consumption of coagulation factors, exacerbating hemorrhage. Identifying optimal resuscitation products for restoring plasma homeostasis following injury is important for improving management of these patients.Objectives:To determine the effects of crystalloid versus plasma resuscitation on thrombin generation in a rat model of trauma and hemorrhagic shock (HS).Patients/Methods:Rats were subjected to trauma and HS followed by resuscitation with Lactated Ringer's solution (LR) or fresh frozen plasma (FFP). Blood was collected at baseline, decompensation, and 3-h post-resuscitation. Thrombin generation was measured by calibrated automated thrombogram and antithrombin III (AT) by ELISA. In a prospective observational study, admission blood samples were collected on highest-level activation trauma patients and diluted with LR or FFP for thrombin generation analysis.Results:Resuscitation with LR resulted in persistent hypercoagulability; however, FFP resuscitation reversed this hypercoagulability to baseline thrombin generation or below. Plasma AT levels decreased following HS and remained low in rats receiving LR, but were corrected in rats receiving FFP. Similarly, in trauma patient plasma LR increased thrombin generation while FFP reduced it. However, results with AT-deficient plasma dilution were similar to LR. In patients with admission hypocoagulability, FFP slightly increased thrombin generation.Conclusions:HS in rats is associated with increased thrombin generation and resuscitation with FFP, not LR, reverses hypercoagulability. Dilution of trauma patient plasma with LR or FFP yielded similar results; however, the modulatory effects of FFP were attenuated when AT was absent. Importantly, FFP reduced thrombin generation in hypercoagulable patient plasma, but slightly increased thrombin generation in hypocoagulable patient plasma. Thus, FFP restores hemostatic balance following trauma and HS which is, in part, by delivering AT.
C1 [Cardenas, Jessica C.; Cap, Andrew P.; Huby, Maria del Pilar; Baer, Lisa A.; Matijevic, Nena; Cotton, Bryan A.; Holcomb, John B.; Wade, Charles E.] Univ Texas Hlth Sci Ctr Houston, Dept Surg, Houston, TX 77030 USA.
[Cardenas, Jessica C.; Swartz, Michael D.; Huby, Maria del Pilar; Baer, Lisa A.; Matijevic, Nena; Cotton, Bryan A.; Holcomb, John B.; Wade, Charles E.] Univ Texas Hlth Sci Ctr Houston, Ctr Translat Injury Res, Houston, TX 77030 USA.
[Cap, Andrew P.] US Army Inst Surg Res, Ft Sam Houston, TX USA.
[Swartz, Michael D.] Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Dept Biostat, Houston, TX 77030 USA.
RP Cardenas, JC (reprint author), Univ Texas Hlth Sci Ctr Houston, 6431 Fannin St,MSB 5-030, Houston, TX 77030 USA.
EM Jessica.C.Cardenas@uth.tmc.edu
FU NHLBI [1F32HL120549-01A1]; State of Texas Emerging Technology Fund;
University of Texas Health Science Center's Center for Translational
Injury Research
FX Support for this work was provided by NHLBI 1F32HL120549-01A1 to J.C.C.,
The State of Texas Emerging Technology Fund, and the University of Texas
Health Science Center's Center for Translational Injury Research.
NR 34
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U1 2
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD FEB
PY 2016
VL 45
IS 2
BP 166
EP 173
DI 10.1097/SHK.0000000000000504
PG 8
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA DD5UB
UT WOS:000369988900009
PM 26529664
ER
PT J
AU Reddoch, KM
Montgomery, RK
Rodriguez, AC
Meledeo, MA
Pidcoke, HF
Ramasubramanian, AK
Cap, AP
AF Reddoch, Kristin M.
Montgomery, Robbie K.
Rodriguez, Armando C.
Meledeo, M. Adam
Pidcoke, Heather F.
Ramasubramanian, Anand K.
Cap, Andrew P.
TI ENDOTHELIUM-DERIVED INHIBITORS EFFICIENTLY ATTENUATE THE AGGREGATION AND
ADHESION RESPONSES OF REFRIGERATED PLATELETS
SO SHOCK
LA English
DT Article
DE Apheresis platelets; cold storage; hemostatic function; inhibition
ID NITRIC-OXIDE; THROMBIN GENERATION; FACTOR-V; PROSTACYCLIN; STORAGE;
CGMP; COLLAGEN; ASPIRIN; CELLS; ASSAY
AB Refrigeration of platelets (4 degrees C) provides the possibility of improving transfusion practice over the current standard-of-care, room temperature (RT) storage. However, the increased level of platelet activation observed at 4 degrees C in vitro is cause for concern of uncontrolled thrombosis in vivo. In this study, we assessed the safety of 4 degrees C-stored platelets by evaluating their response to physiologic inhibitors prostacyclin (PGI(2)) and nitric oxide (NO). Apheresis platelets were collected from healthy donors (n=4) and tested on Day 1 (fresh) or Day 5 (RT- and 4 degrees C-stored) after treatment with PGI(2) and NO or not for: thrombin generation; factor V (FV) activity; intracellular free calcium, cAMP and cGMP; ATP release; TRAP-induced activation; aggregation to ADP, collagen, and TRAP, and adhesion to collagen under arterial flow. Data were analyzed using two-way ANOVA and post-hoc Tukey test for multiple comparisons, with significance set at P<0.05. Treatment with inhibitors increased intracellular cAMP and cGMP levels in fresh and stored platelets. Thrombin generation was significantly accelerated in stored platelets consistent with increased factor V levels, PS exposure, CD62P expression, intracellular free calcium, and ATP release. While treatment with inhibitors did not attenuate thrombin generation in stored platelets, activation, aggregation, and adhesion responses were inhibited by both PGI(2) and NO in 4 degrees C-stored platelets. In contrast, though RT-stored platelets were activated, they did not adhere or aggregate in response to agonists. Thus, refrigerated platelets maintain their intracellular machinery, are responsive to agonists and platelet function inhibitors, and perform hemostatically better than RT-stored platelets.
C1 [Reddoch, Kristin M.; Montgomery, Robbie K.; Rodriguez, Armando C.; Meledeo, M. Adam; Ramasubramanian, Anand K.] Univ Texas San Antonio, Dept Biomed Engn, San Antonio, TX 78256 USA.
[Reddoch, Kristin M.; Pidcoke, Heather F.; Cap, Andrew P.] US Army, Inst Surg Res, Coagulat & Blood Res Program, Ft Sam Houston, TX 78234 USA.
RP Ramasubramanian, AK (reprint author), Univ Texas San Antonio, Dept Biomed Engn, San Antonio, TX 78256 USA.; Cap, AP (reprint author), US Army, Inst Surg Res, Coagulat & Blood Res Program, Ft Sam Houston, TX 78234 USA.; Cap, AP (reprint author), US Army, Inst Surg Res, Blood Res Program, Ft Sam Houston, TX 78234 USA.
EM anand.rama-subramanian@utsa.edu; andrew.p.cap.mil@mail.mil
FU Department of Defense [W81XWH-13-P-0146]; American Heart Association
[14PRE19580011]
FX This study was supported by a contract from the Department of Defense
(W81XWH-13-P-0146) and by American Heart Association Grant 14PRE19580011
(Kristin Reddoch).
NR 35
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U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD FEB
PY 2016
VL 45
IS 2
BP 220
EP 227
DI 10.1097/SHK.0000000000000493
PG 8
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA DD5UB
UT WOS:000369988900015
PM 26555740
ER
PT J
AU Khraiwesh, M
Leed, S
Roncal, N
Johnson, J
Sciotti, R
Smith, P
Read, L
Paris, R
Hudson, T
Hickman, M
Grogl, M
AF Khraiwesh, Mozna
Leed, Susan
Roncal, Norma
Johnson, Jacob
Sciotti, Richard
Smith, Philip
Read, Lisa
Paris, Robert
Hudson, Thomas
Hickman, Mark
Grogl, Max
TI Antileishmanial Activity of Compounds Derived from the Medicines for
Malaria Venture Open Access Box against Intracellular Leishmania major
Amastigotes
SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Article
ID CUTANEOUS LEISHMANIASIS; IN-VITRO; AXENIC AMASTIGOTES; COLORIMETRIC
ASSAY; GENE-EXPRESSION; DRUG DISCOVERY; AMPHOTERICIN-B; MACROPHAGES;
IDENTIFICATION; PROMASTIGOTES
AB Leishmaniasis is a complex tropical disease caused by kinetoplastid parasitic protozoa of the genus Leishmania and is transmitted by the sand fly insect vector. Cutaneous leishmaniasis (CL) is the most common form of this disease, and CL infections often result in serious skin lesions and scars. CL remains a public health problem in many endemic countries worldwide because of the absence of effective, safe, and cost-effective drugs for treatment. One of the strategies we chose to use to find novel chemical entities worthy of further development as antileishmanials involved screening synthetic and natural products libraries. In our study, we developed a Leishmania major intracellular amastigote assay that uses the activity of luciferase as a measure of parasite proliferation and used this assay to screen a collection of 400 compounds obtained from Medicines for Malaria Venture (MMV) for their antileishmanial activity. Our results showed that 14 compounds identified by MMV as antimalarial drugs have antileishmanial activity and can potentially be optimized for CL drug development.
C1 [Khraiwesh, Mozna] Walter Reed Army Inst Res, Div Expt Therapeut, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
Madigan Army Med Ctr, Dept Clin Invest, Tacoma, WA 98431 USA.
Walter Reed Army Inst Res, Mil Malaria Res Program, Silver Spring, MD USA.
RP Khraiwesh, M (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM mozna.h.khraiwesh.ctr@mail.mil
NR 39
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U1 1
U2 4
PU AMER SOC TROP MED & HYGIENE
PI MCLEAN
PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA
SN 0002-9637
EI 1476-1645
J9 AM J TROP MED HYG
JI Am. J. Trop. Med. Hyg.
PD FEB
PY 2016
VL 94
IS 2
BP 340
EP 347
DI 10.4269/ajtmh.15-0448
PG 8
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA DC8JK
UT WOS:000369465500016
PM 26503273
ER
PT J
AU Kardouni, JR
AF Kardouni, Joseph R.
TI IMAGES IN EMERGENCY MEDICINE DIAGNOSIS: Distal radius fracture
SO ANNALS OF EMERGENCY MEDICINE
LA English
DT Editorial Material
ID EPIDEMIOLOGY
C1 [Kardouni, Joseph R.] US Army Res Inst Environm Med, Mil Performance Div, Natick, MA USA.
RP Kardouni, JR (reprint author), US Army Res Inst Environm Med, Mil Performance Div, Natick, MA USA.
NR 4
TC 0
Z9 0
U1 0
U2 1
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0196-0644
J9 ANN EMERG MED
JI Ann. Emerg. Med.
PD FEB
PY 2016
VL 67
IS 2
BP 165
EP +
DI 10.1016/j.annemergmed.2015.06.004
PG 2
WC Emergency Medicine
SC Emergency Medicine
GA DC3MW
UT WOS:000369124400006
PM 26801377
ER
PT J
AU Park, S
Lee, LS
Medina, VF
Zull, A
Waisner, S
AF Park, Saerom
Lee, Linda S.
Medina, Victor F.
Zull, Aaron
Waisner, Scott
TI Heat-activated persulfate oxidation of PFOA, 6:2 fluorotelomer
sulfonate, and PFOS under conditions suitable for in-situ groundwater
remediation
SO CHEMOSPHERE
LA English
DT Article
DE PFOA; PFOS; 6:2 FTSA; Heat-activated persulfate; Oxidation
ID PERFLUOROOCTANOIC ACID PFOA; PERFLUOROCARBOXYLIC ACIDS; EFFICIENT
DECOMPOSITION; PERFLUORINATED SURFACTANTS; HOT-WATER; KINETICS;
DEGRADATION; FLUOROCHEMICALS; TRANSFORMATION; MECHANISM
AB PFOA (perfluorooctanoic acid) oxidation (0.121-6.04 mu M) by heat-activated persulfate was evaluated at 20-60 degrees C with 4.2-84 mM S2O82- and in the presence of soluble fuel components to assess feasibility for in-situ remediation of groundwater. 6:2 fluorotelomer sulfonic acid/sulfonate (6:2 FTSA) and PFOS (perfluorooctanesulfonic acid) persulfate oxidation was also evaluated in a subset of conditions given their co-occurrence at many sites. High performance liquid chromatography electron spray tandem mass spectrometry was used for organic analysis and fluoride was measured using a fluoride-specific electrode. PFOA pseudo-1st order transformation rates (k(1,PFOA)) increased with increasing temperature (half-lives from 0.1 to 7 d for 60 to 30 degrees C) sequentially removing CF2 groups ('unzipping') to shorter chain perfluoroalkyl carboxylic acids (PFCAs) and F. At 50 degrees C, a 5-fold increase in S2O82- led to a 5-fold increase in k(1,PFOA) after which self-scavenging by sulfate radicals decreased the relative rate of increase with more S2O82-. Benzene, toluene, ethylbenzene and xylene did not affect k(1,PFOA) even at 40 times higher molar concentrations than PFOA. A modeling approach to explore pathways strongly supported that for 6:2 FTSA, both the ethyl linkage and CF2-CH2 bond of 6:2 FTSA oxidize simultaneously, resulting in a ratio of similar to 25/75 PFHpA/PFHxA. The effectiveness of heat-activated S2O82- on PFOA oxidation was reduced in a soil slurry; therefore, repeated persulfate injections are required to efficiently achieve complete oxidation in the field. However, PFOS remained unaltered even at higher activation temperatures, thus limiting the sole use of heat-activated persulfate for perfluoroalkyl substances removal in the field. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Park, Saerom; Lee, Linda S.; Zull, Aaron] Purdue Univ, Dept Agron Ecol Sci & Engn, W Lafayette, IN 47907 USA.
[Medina, Victor F.; Waisner, Scott] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Lee, LS (reprint author), Purdue Univ, Ecol Sci & Engn Interdisciplinary Grad Program, W Lafayette, IN 47907 USA.
EM lslee@purdue.edu
OI Waisner, Scott/0000-0003-4360-4712
FU Air Force Center of Engineering and Environment (AFCEE) [BAA715, EL-3]
FX This work was funded by the Air Force Center of Engineering and
Environment (AFCEE, #BAA715, EL-3). We also wish to acknowledge Stephen
Sassman and Chloe De Perre for their analytical chemistry support.
NR 43
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U1 38
U2 103
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0045-6535
EI 1879-1298
J9 CHEMOSPHERE
JI Chemosphere
PD FEB
PY 2016
VL 145
BP 376
EP 383
DI 10.1016/j.chemosphere.2015.11.097
PG 8
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA DC4MZ
UT WOS:000369196300048
PM 26692515
ER
PT J
AU Costanzo, MR
Negoianu, D
Jaski, BE
Bart, BA
Heywood, JT
Anand, IS
Smelser, JM
Kaneshige, AM
Chomsky, DB
Adler, ED
Haas, GJ
Watts, JA
Nabut, JL
Schollmeyer, MP
Fonarow, GC
AF Costanzo, Maria Rosa
Negoianu, Daniel
Jaski, Brian E.
Bart, Bradley A.
Heywood, James T.
Anand, Inder S.
Smelser, James M.
Kaneshige, Alan M.
Chomsky, Don B.
Adler, Eric D.
Haas, Garrie J.
Watts, James A.
Nabut, Jose L.
Schollmeyer, Michael P.
Fonarow, Gregg C.
TI Aquapheresis Versus Intravenous Diuretics and Hospitalizations for Heart
Failure
SO JACC-HEART FAILURE
LA English
DT Article
DE aquapheresis; congestion; fluid overload; heart failure;
hospitalizations; loop diuretics; worsening renal function
ID CONTINUOUS ULTRAFILTRATION; CARDIORENAL SYNDROME; TRIAL; FLUID
AB OBJECTIVES The AVOID-HF (Aquapheresis versus Intravenous Diuretics and Hospitalization for Heart Failure) trial tested the hypothesis that patients hospitalized for HF treated with adjustable ultrafiltration (AUF) would have a longer time to first HF event within 90 days after hospital discharge than those receiving adjustable intravenous loop diuretics (ALD).
BACKGROUND Congestion in hospitalized heart failure (HF) patients portends unfavorable outcomes.
METHODS The AVOID-HF trial, designed as a multicenter, 1-to-1 randomized study of 810 hospitalized HF patients, was terminated unilaterally and prematurely by the sponsor (Baxter Healthcare, Deerfield, Illinois) after enrollment of 224 patients (27.5%). Aquadex FlexFlow System (Baxter Healthcare) was used for AUF. A Clinical Events Committee, blinded to the randomized treatment, adjudicated whether 90-day events were due to HF.
RESULTS A total of 110 patients were randomized to AUF and 114 to ALD. Baseline characteristics were similar. Estimated days to first HF event for the AUF and ALD group were, respectively, 62 and 34 (p = 0.106). At 30 days, compared with the ALD group, the AUF group had fewer HF and cardiovascular events. Renal function changes were similar. More AUF patients experienced an adverse effect of special interest (p = 0.018) and a serious study product-related adverse event (p = 0.026). The 90-day mortality was similar.
CONCLUSIONS Compared with the ALD group, the AUF group trended toward a longer time to first HF event within 90 days and fewer HF and cardiovascular events. More patients in the AUF group experienced special interest or serious product-related adverse event. Due to the trial's untimely termination, additional AUF investigation is warranted. (C) 2016 by the American College of Cardiology Foundation.
C1 [Costanzo, Maria Rosa] Edward Heart Hosp, Advocate Heart Inst, 4th Floor,801 South Washington St, Naperville, IL 60566 USA.
[Negoianu, Daniel] Univ Penn, Med Ctr, Div Nephrol, Philadelphia, PA 19104 USA.
[Jaski, Brian E.] Sharp Mem Hosp & Rehabil Ctr, San Diego Cardiac Ctr, San Diego, CA USA.
[Bart, Bradley A.] Hennepin Cty Med Ctr, Dept Med, Div Cardiol, Minneapolis, MN 55415 USA.
[Heywood, James T.] Scripps Clin, Heart Failure Recovery & Res Program, San Diego, CA USA.
[Anand, Inder S.] Univ Minnesota, VA Med Ctr, Minneapolis, MN USA.
[Smelser, James M.] Huntsville Renal Clin, Huntsville, AL USA.
[Kaneshige, Alan M.] Oklahoma Heart Inst, Tulsa, OK USA.
[Chomsky, Don B.] St Thomas Heart Hosp, Nashville, TN USA.
[Adler, Eric D.] Univ Calif San Diego, Div Cardiol, San Diego, CA 92103 USA.
[Haas, Garrie J.] Ohio State Univ, Div Cardiol, Columbus, OH 43210 USA.
[Watts, James A.] Brooke Army Med Ctr, San Antonio, TX USA.
[Nabut, Jose L.; Schollmeyer, Michael P.] Baxter Healthcare Corp, Deerfield, IL 60015 USA.
[Fonarow, Gregg C.] Univ Calif Los Angeles, Div Cardiol, Los Angeles, CA USA.
RP Costanzo, MR (reprint author), Edward Heart Hosp, Advocate Heart Inst, 4th Floor,801 South Washington St, Naperville, IL 60566 USA.
EM mariarosa.costanzo@advocatehealth.com
NR 20
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Z9 13
U1 2
U2 5
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 2213-1779
EI 2213-1787
J9 JACC-HEART FAIL
JI JACC-Heart Fail.
PD FEB
PY 2016
VL 4
IS 2
BP 95
EP 105
DI 10.1016/j.jchf.2015.08.005
PG 11
WC Cardiac & Cardiovascular Systems
SC Cardiovascular System & Cardiology
GA DC4LK
UT WOS:000369192200001
PM 26519995
ER
PT J
AU Jutel, M
Agache, I
Bonini, S
Burks, W
Calderon, M
Canonica, W
Cox, LD
Demoly, P
Frew, AJ
O'Hehir, R
Kleine-Tebbe, J
Muraro, A
Lack, G
Larenas, D
Levin, M
Martin, BL
Nelson, H
Pawankar, R
Pfaar, O
van Ree, R
Sampson, H
Sublett, JL
Sugita, K
Du Toit, G
Werfel, T
van Wijk, RG
Zhang, L
Akdis, M
Akdis, CA
AF Jutel, Marek
Agache, Ioana
Bonini, Sergio
Burks, Wesley
Calderon, Moises
Canonica, Walter
Cox, Linda
Demoly, Pascal
Frew, Antony J.
O'Hehir, Robyn
Kleine-Tebbe, Joerg
Muraro, Antonella
Lack, Gideon
Larenas, Desiree
Levin, Michael
Martin, Bryan L.
Nelson, Harald
Pawankar, Ruby
Pfaar, Oliver
van Ree, Ronald
Sampson, Hugh
Sublett, James L.
Sugita, Kazunari
Du Toit, George
Werfel, Thomas
van Wijk, Roy Gerth
Zhang, Luo
Akdis, Muebeccel
Akdis, Cezmi A.
TI International Consensus on Allergen Immunotherapy II: Mechanisms,
standardization, and pharmacoeconomics
SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
LA English
DT Article
DE International consensus; allergy; immunotherapy; allergen vaccine;
allergen standardization; pharmacoeconomics; cost-effectiveness;
mechanisms; tolerance; marketing authorization; regulatory authorities;
unmet needs
ID GRASS-POLLEN IMMUNOTHERAPY; REGULATORY T-CELLS; COST-EFFECTIVENESS
ANALYSIS; HISTAMINE-RECEPTOR 2; TOLL-LIKE RECEPTORS;
ECONOMIC-EVALUATION; SUBLINGUAL IMMUNOTHERAPY; SYMPTOMATIC TREATMENT;
IMMUNE-RESPONSES; B-CELLS
AB This article continues the comprehensive international consensus (ICON) statement on allergen immunotherapy (AIT). The initial article also recently appeared in the Journal. The conclusions below focus on key mechanisms of AIT-triggered tolerance, requirements in allergen standardization, AIT cost-effectiveness, and regulatory guidance. Potential barriers to and facilitators of the use of AIT are described in addition to future directions. International allergy specialists representing the European Academy of Allergy and Clinical Immunology; the American Academy of Allergy, Asthma & Immunology; the American College of Allergy, Asthma and Immunology; and the World Allergy Organization critically reviewed the existing literature and prepared this summary of recommendations for best AIT practice. The authors contributed equally and reached consensus on the statements presented herein.
C1 [Jutel, Marek] Wroclaw Med Univ, Dept Clin Immunol, Chalubinskiego 5, PL-50368 Wroclaw, Poland.
[Jutel, Marek] ALL MED Med Res Inst, Wroclaw, Poland.
[Agache, Ioana] Transylvania Univ, Fac Med, Brasov, Romania.
[Bonini, Sergio] Univ Naples 2, Rome, Italy.
[Bonini, Sergio] IFT CNR, Rome, Italy.
[Bonini, Sergio] Expert On Secondment European Med Agcy, London, England.
[Burks, Wesley] Univ N Carolina, Dept Pediat, Chapel Hill, NC USA.
[Calderon, Moises] Univ London Imperial Coll Sci Technol & Med, Sect Allergy & Clin Immunol, Natl Heart & Lung Inst, Royal Brompton Hosp, London SW7 2AZ, England.
[Canonica, Walter] DIMI Univ Genoa, Allergy & Resp Dis Clin, IRCCS AOU San Martino, Genoa, Italy.
[Cox, Linda] Ctr Asthma & Allergy, Ft Lauderdale, FL USA.
[Demoly, Pascal] Univ Hosp Montpellier, INSERM, U657, Montpellier, France.
[Frew, Antony J.] Royal Sussex Cty Hosp, Dept Resp Med, Brighton, E Sussex, England.
[O'Hehir, Robyn] Alfred Hosp, Dept Allergy Immunol & Resp Med, Melbourne, Vic, Australia.
[O'Hehir, Robyn] Monash Univ, Melbourne, Vic, Australia.
[Kleine-Tebbe, Joerg] Allergy & Asthma Ctr Westend, Berlin, Germany.
[Muraro, Antonella] Padua Gen Univ Hosp, Dept Mother & Child Hlth, Padua, Italy.
[Lack, Gideon] MRC, Div Asthma Allergy & Lung Biol, London W1N 4AL, England.
[Lack, Gideon] Kings Coll London, Asthma UK Ctr Allerg Mech Asthma, London WC2R 2LS, England.
[Lack, Gideon] Guys & St Thomas NHS Fdn Trust, Childrens Allergy Unit, London, England.
[Larenas, Desiree] Hosp Med Sur, Mexico City, DF, Mexico.
[Levin, Michael] Red Cross War Mem Childrens Hosp, Sch Child & Adolescent Hlth, Div Allergy, Cape Town, South Africa.
[Martin, Bryan L.] Walter Reed Army Med Ctr, Dept Allergy & Immunol, Silver Spring, MD USA.
[Nelson, Harald] Natl Jewish Hlth, Denver, CO USA.
[Pawankar, Ruby] Nippon Med Sch, Dept Pediat, 1-1-5 Sendagi, Tokyo 113, Japan.
[Pfaar, Oliver] Univ Hosp Mannheim, Ctr Rhinol & Allergol, Dept Otorhinolaryngol Head & Neck Surg, Mannheim, Germany.
[van Ree, Ronald] Univ Amsterdam, Acad Med Ctr, Dept Expt Immunol, NL-1012 WX Amsterdam, Netherlands.
[van Ree, Ronald] Univ Amsterdam, Acad Med Ctr, Dept Otorhinolaryngol, NL-1012 WX Amsterdam, Netherlands.
[Sampson, Hugh] Icahn Sch Med Mt Sinai, Dept Pediat, Div Allergy Immunol, New York, NY 10029 USA.
[Sampson, Hugh] Icahn Sch Med Mt Sinai, Jaffe Food Allergy Inst, New York, NY 10029 USA.
[Sublett, James L.] Univ Louisville, Sch Med, Sect Allergy & Immunol, Dept Pediat, Louisville, KY 40292 USA.
[Sugita, Kazunari; Akdis, Muebeccel; Akdis, Cezmi A.] Univ Zurich, Swiss Inst Allergy & Asthma Res, CH-8006 Zurich, Switzerland.
[Sugita, Kazunari; Akdis, Muebeccel; Akdis, Cezmi A.] Christine Kuhne Ctr Allergy Res & Educ, Davos, Switzerland.
[Du Toit, George] Kings Coll London, Div Asthma Allergy & Lung Biol, Dept Pediat Allergy, London WC2R 2LS, England.
[Du Toit, George] MRC, London W1N 4AL, England.
[Du Toit, George] Asthma UK Ctr Allerg Mech Asthma, London, England.
[Werfel, Thomas] Hannover Med Sch, Div Immunodermatol & Allergy Res, Dept Dermatol & Allergy, Hannover, Germany.
[van Wijk, Roy Gerth] Erasmus MC, Rotterdam, Netherlands.
[Zhang, Luo] Beijing Inst Otolaryngol, Beijing, Peoples R China.
RP Jutel, M (reprint author), Wroclaw Med Univ, Dept Clin Immunol, Chalubinskiego 5, PL-50368 Wroclaw, Poland.
EM marek.jutel@umed.wroc.pl
RI O'Hehir, Robyn/H-3627-2011;
OI O'Hehir, Robyn/0000-0002-3489-7595; SUBLETT, JAMES L/0000-0003-4696-4609
FU Anergis; Allergopharma; GLG Research (Gerson Lehrman Group); ActoGeniX;
Genentech; Sanofi US Services; Valeant Pharmaceuticals North America;
ALK-Abello; Stallergenes; Merck; Greer; Circassia; Stallergenes-Greer;
DBV; Thermo Fisher Scientific; Chiesi; Pierre Fabre Medicament;
Menarini; MSD; AstraZeneca; NIHR (UK); MEDA; Pfizer; MIT; BI; Novartis
Glenmark; Novartis; UCB; GlaxoSmithKline; Astra Zeneca; Senosiain;
Sanofi; TEVA; Carnot; Glenmark; Mylan; Pharma Dynamics; INNOVA Pharma;
Medical Research Council of South Africa; Thermo Fisher;
GlaxoSmithKline/Aspen; Cipla; Astellas; Beiersdorf; Takeda Nycomed;
Pearl Therapeutics; Allergopharma (Germany); ALK-Abello (Denmark);
Stallergenes (France); HAL-Allergy (Netherlands); Artu Biologicals
(Netherlands); Allergy Therapeutics/Bencard (United Kingdom/Germany);
Hartington (Spain); Lofarma (Italy); Novartis/Leti (Germany/Spain);
GlaxoSmithKline (United Kingdom); Essex-Pharma (Germany); Cytos
(Switzerland); Curalogic (Denmark); Roxall (Germany); Biomay (Austria);
Thermo Fisher (United States); Circassia (United Kingdom); E.U; Biotech
Tools (Belgium); MEDA-Pharma (Sweden); Anergis (Switzerland); Bencard
(Germany); Novartis/LETI (Germany); MEDA-Pharma (Germany); GfK
Bridgehead (United Kingdom); NAVIGANT-consulting (United States); Sanofi
(United States); Guide-point Global Advisors (United States);
Pohl-Boskamp (Germany); Mobile Chamber Experts (a GA2LEN partner,
Germany); HAL-Allergy (Germany/Netherlands); GlaxoSmithKline (Germany);
Thermo-Fisher (Germany); Schattauer (Germany); Springer (Germany);
European Academy of Allergy and Clinical Immunology (EAACI); German
Society for Allergology and Clinical Immunology (DGAKI); German
Respiratory Society (DGP); European Commission; Scientific Advisory
Board Chair for HAL Allergy BV; Bayer CropScience; National Institute of
Allergy and Infectious Diseases (NIAID) [NO1-AI-15416, UM1AI109565];
Food Allergy and Research Education (FARE); UK Department of Health
through NIHR; HAL; Crucell; Emerade; NOW; STW; Biomay; Actelion;
Aventis; Circacia; PREDICTA (European Commission's Seventh Framework
programme) [260895]; Swiss National Science Foundation; MeDALL (European
Commission's Seventh Framework Programme) [261357]; Christine
Kuhne-Center
FX M. Jutel has received consultancy fees from Anergis and has received
lecture fees from Allergopharma. S. Bonini has received travel support
and is an expert on secondment at the European Medicine Agency. A. W.
Burks is on the FARE and World Allergy Organization boards; is on the
Murdoch Children's Research Institute Advisory Board; is an unpaid
consultant for Dynavax Technologies, Perrigo Company (PBN Nutritionals),
and Perosphere; has received consultancy fees from GLG Research (Gerson
Lehrman Group), ActoGeniX, Genentech, Sanofi US Services, and Valeant
Pharmaceuticals North America; is employed by the University of North
Carolina; has patents US5558869, US55973121, US6441142, US6486311,
US6835824, US7485708, and US7879977; has received payment for developing
educational presentations from Current Views 2012; has stock/stock
options in Allertein and Mastcell Pharmaceuticals; and has received
travel support for various grand rounds and presentations. M. Calderon
is on the boards for ALK-Abello and HAL Allergy, has received
consultancy fees from ALK-Abello and Stallergenes, and has received
lecture fees from ALK-Abello, Stallergenes, Merck, and Allergopharma. L.
Cox has received personal fees from Greer and is the lead author on one
of the studies discussed in the correspondence (publication date 2011)
but has had no relationship with the sponsoring company in the past 36
months. P. Demoly has received consultancy fees from ALK-Abello,
Circassia, Stallergenes-Greer, Allergopharma, DBV, Thermo Fisher
Scientific, Chiesi, and Pierre Fabre Medicament and has received lecture
fees from Menarini, MSD, and AstraZeneca. A. J. Frew is on the
ALK-Abello board and has received research support from NIHR (UK). D.
Larenas is on the CMICA board with no financial gain; has received
consultancy fees from MEDA, Pfizer, MIT, BI, Novartis Glenmark, and
Chiesi; has received research support from Novartis, Pfizer, MEDA, UCB,
GlaxoSmithKline, Astra Zeneca, Senosiain, Sanofi, MSD, TEVA, and Carnot;
has received lecture fees from Novartis, Pfizer, MEDA, Astra Zeneca,
Sanofi, MSD, TEVA, and Chiesi; has received payment for development of
educational presentations from Glenmark; and has received travel support
from Novartis, Pfizer, MEDA, AstraZeneca, Sanofi, MSD, and Chiesi. M
Levin is on the boards for the Allergy Society of South Africa and the
Allergy Foundation of South Africa; has received consultancy fees from
Mylan, Pharma Dynamics, and INNOVA Pharma; has received research support
from Mylan, the Medical Research Council of South Africa, Thermo Fisher,
GlaxoSmithKline/Aspen, AstraZeneca, Cipla, Astellas, Pharma Dynamics,
and Beiersdorf; and has received lecture fees from Cipla, Takeda
Nycomed, Pharma Dynamics, and Novartis. H. Nelson has received research
support from Circassia and has received consulting fees from Circassia,
Merck, Pearl Therapeutics and AstraZeneca. O. Pfaar has received
research grants for his institution from Allergopharma (Germany),
ALK-Abello (Denmark), Stallergenes (France), HAL-Allergy (Netherlands),
Artu Biologicals (Netherlands), Allergy Therapeutics/Bencard (United
Kingdom/Germany), Hartington (Spain), Lofarma (Italy), Novartis/Leti
(Germany/Spain), GlaxoSmithKline (United Kingdom), Essex-Pharma
(Germany), Cytos (Switzerland), Curalogic (Denmark), Roxall (Germany),
Biomay (Austria), Thermo Fisher (United States), Circassia (United
Kingdom), E.; U (FP-7-Health-2013-Innovation 1), Biotech Tools
(Belgium), and MEDA-Pharma (Sweden); has received personal payments as
consultant for Allergopharma (Germany), Anergis (Switzerland), Bencard
(Germany), HAL-Allergy (Netherlands), Novartis/LETI (Germany),
MEDA-Pharma (Germany), ALK-Abello (Denmark), Biotech Tools (Belgium),
GfK Bridgehead (United Kingdom), NAVIGANT-consulting (United States),
Sanofi (United States), Guide-point Global Advisors (United States),
Pohl-Boskamp (Germany), Stallergenes (France), and Mobile Chamber
Experts (a GA2LEN partner, Germany); has received personal payments for
lectures, book chapters, or educational presentations from ALK-Abello
(Denmark), Allergopharma (Germany), Stallergenes (France), HAL-Allergy
(Germany/Netherlands), Allergy Therapeutics/Bencard (United
Kingdom/Germany), Hartington (Spain), Lofarma (Italy), Novartis/Leti
(Germany/Spain), GlaxoSmithKline (Germany), Roxall (Germany),
Thermo-Fisher (Germany), MEDA-Pharma (Germany), Schattauer (Germany),
Springer (Germany). and GlaxoSmithKline (Germany); has served as advisor
and on the speakers' bureaus for some of the aforementioned companies;
has received travel grants from HAL-Allergy (Netherlands), Allergopharma
(Germany), the European Academy of Allergy and Clinical Immunology
(EAACI), the German Society for Allergology and Clinical Immunology
(DGAKI), and the German Respiratory Society (DGP); and is the current
chairman of the Immunotherapy Interest Group (IT IG) of the EAACI and is
secretary of the ENT section of the DGAKI. R van Ree has received
research support from the European Commission; has received consultancy
fees as the Scientific Advisory Board Chair for HAL Allergy BV; is Vice
President of the EAACI; has received consultancy fees from Bayer
CropScience; and has received lecture fees from Thermo Fisher
Scientific. H. Sampson, as of November 1, 2015, is a part-time employee
of DBV Technologies and serves as their Chief Scientific Officer; DBV
Technologies is developing an epicutaneous patch for the treatment of
peanut allergy and other disorders. G. Du Toit has received research
support from the National Institute of Allergy and Infectious Diseases
(NIAID; NO1-AI-15416 [contract] and UM1AI109565 [grant], covering
salary); has received contribution to NIAID contract/grant from Food
Allergy and Research Education (FARE); has received Contribution to the
KCL Division of Asthma, Allergy & Lung Biology (of which Pediatric
Allergy Research is a part) from MRC & Asthma UK Centre; has received a
BRC award to Guy's and St Thomas' NHS Foundation from the UK Department
of Health through NIHR; and has equity holding in FoodMaestro. R Gerth
van Wijk has received consultancy fees from MSD, HAL, Crucell,
ALK-Abello, Novartis, and Emerade; has received research support from
NOW, STW, Novartis, Biomay, and DBV; has received lecture fees from
Allergopharma and Thermo Fisher; has received payment for manuscript
preparation from Chiesi; and receives royalties from de Tijdstroom and
Bohn, Stafleu, van Loghum. C. A. Akdis has received consultancy fees
from Actelion, Aventis, Stallergenes, Allergopharma, and Circacia; is
employed by the Swiss Institute of Allergy and Asthma Research,
University of Zurich, Switzerland; has received research support from
Novartis, PREDICTA (European Commission's Seventh Framework programme
no. 260895), the Swiss National Science Foundation, MeDALL (European
Commission's Seventh Framework Programme no. 261357), and the Christine
Kuhne-Center. The rest of the authors declare that they have no relevant
conflicts of interest.
NR 91
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U1 0
U2 13
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0091-6749
EI 1097-6825
J9 J ALLERGY CLIN IMMUN
JI J. Allergy Clin. Immunol.
PD FEB
PY 2016
VL 137
IS 2
BP 358
EP 368
DI 10.1016/j.jaci.2015.12.1300
PG 11
WC Allergy; Immunology
SC Allergy; Immunology
GA DC5BN
UT WOS:000369235500003
PM 26853128
ER
PT J
AU O'Connor, KL
Scisco, JL
Smith, TJ
Young, AJ
Montain, SJ
Price, LL
Lieberman, HR
Karl, JP
AF O'Connor, Kristie L.
Scisco, Jenna L.
Smith, Tracey J.
Young, Andrew J.
Montain, Scott J.
Price, Lori Lyn
Lieberman, Harris R.
Karl, J. Philip
TI Altered Appetite-Mediating Hormone Concentrations Precede Compensatory
Overeating After Severe, Short-Term Energy Deprivation in Healthy Adults
SO JOURNAL OF NUTRITION
LA English
DT Article
DE calorie restriction; energy density; satiety; weight loss; gut hormone;
intermittent fasting; energy balance
ID GLUCAGON-LIKE PEPTIDE-1; FOOD-INTAKE; WEIGHT-LOSS; BODY-WEIGHT; OBESE
MEN; DIETARY RESTRICTION; INTAKE RESPONSES; GHRELIN LEVELS; CENTRAL
LEPTIN; EATING RATE
AB Background: Adaptive responses of appetite-mediating hormones to negative energy balance are thought to contribute to a counterregulatory response that drives weight regain, but they have not been studied while controlling for reduced diet volume.
Objective: In this secondary analysis, we aimed to determine the effects of short-term, severe energy deprivation (ED) on appetite and appetite-mediating hormone concentrations.
Methods: Twenty-one adults with a mean +/- SD age of 21 +/- 3 y and body mass index of 25 +/- 3 kg/m(2) consumed isovolumetric diets provided over separate 48-h periods while increasing habitual energy expenditure by 1683 +/- 329 kcal/d through light- and moderate-intensity exercise. Energy intake was matched to energy expenditure to maintain energy balance (EB) (-44 +/- 92 kcal/d) or was <10% of energy expenditure to generate a 3696 +/- 742-kcal/d energy deficit. Postprandial appetite, glucose, insulin, acyl ghrelin, peptide YY, pancreatic polypeptide (PP), and glucagon-like peptide-1 (GLP-1) responses and ad libitum energy intake were measured as secondary outcomes after both experimental periods.
Results: Fasting insulin (-56% +/- 42%) and acyl ghrelin (-60% +/- 17%) concentrations decreased during ED but not during EB (condition-by-time interaction; P-interaction <= 0.01), whereas fasting leptin concentrations decreased more during ED compared with during EB (-47% +/- 27% compared with 20% +/- 27%; P-interaction = 0.05). Postprandial insulin (57% +/- 63%; P < 0.001), GLP-1 (14% +/- 28%; P = 0.04), and PP (54% +/- 52%; P < 0.001) areas under the curve (AUCs) were higher, whereas the acyl ghrelin AUC was lower (-56% +/- 13%; P < 0.001) after ED compared with after EB. After ED, self-rated appetite was greater, and ad libitum energy intake was 811 kcal/36 h (95% CI: 184, 1439 kcal/36 h) higher relative to after EB (P = 0.01).
Conclusions: Short-term, severe ED suppressed acyl ghrelin concentrations and increased postprandial anorexigenic hormone concentrations. These effects preceded compensatory overeating, suggesting that in adults without obesity, altered sensitivity to appetite-mediating hormones may contribute to an adaptive counterregulatory response during the initial stages of negative EB. This trial was registered at clinicaltrials.gov as NCT01603550.
C1 [O'Connor, Kristie L.; Scisco, Jenna L.; Smith, Tracey J.; Young, Andrew J.; Montain, Scott J.; Lieberman, Harris R.; Karl, J. Philip] US Army, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA.
[Price, Lori Lyn] Tufts Univ, Tufts Med Ctr, Inst Clin Res & Hlth Policy Studies, Boston, MA 02111 USA.
[Price, Lori Lyn] Tufts Univ, Tufts Clin & Translat Sci Inst, Boston, MA 02111 USA.
RP Karl, JP (reprint author), US Army, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA.
EM james.p.karl.civ@mail.mil
FU US Army Medical Research and Materiel Command
FX Supported by the US Army Medical Research and Materiel Command.
NR 56
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U1 5
U2 16
PU AMER SOC NUTRITION-ASN
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD FEB
PY 2016
VL 146
IS 2
BP 209
EP 217
DI 10.3945/jn.115.217976
PG 9
WC Nutrition & Dietetics
SC Nutrition & Dietetics
GA DC9RD
UT WOS:000369557800005
PM 26740683
ER
PT J
AU Penn, AH
Carver, LJ
Herbert, CA
Lai, TS
McIntire, MJ
Howard, JT
Taylor, SF
Schmid-Schonbein, GW
Dobkins, KR
AF Penn, Alexander H.
Carver, Leslie J.
Herbert, Carrie A.
Lai, Tiffany S.
McIntire, Melissa J.
Howard, Jeffrey T.
Taylor, Sharon F.
Schmid-Schoenbein, Geert W.
Dobkins, Karen R.
TI Breast Milk Protects Against Gastrointestinal Symptoms in Infants at
High Risk for Autism During Early Development
SO JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
LA English
DT Article
DE abdominal discomfort/pain; breast milk; breast-feeding; constipation;
pervasive developmental disorder
ID SPECTRUM DISORDERS; INTESTINAL PERMEABILITY; NECROTIZING ENTEROCOLITIS;
MUCOSAL INJURY; FATTY-ACIDS; OLEIC-ACID; CHILDREN; MUCUS; INDIVIDUALS;
POPULATION
AB Objectives: Parents of children with autism spectrum disorders (ASDs) often report gastrointestinal (GI) dysfunction in their children. The objectives of the present study were to determine whether infants at high risk for developing ASD (ie, siblings of children diagnosed as having ASD) show greater prevalence of GI problems and whether this prevalence is associated with diet and age at weaning from breast milk.
Methods:Using questionnaires, diet history and GI problems were tracked prospectively and retrospectively in 57 high-risk infants and for comparison in 114 low-risk infants (infants from families without ASD history).
Results: In low-risk infants, prevalence of GI symptoms, in aggregate, did not vary with diet or age of weaning. By contrast, high-risk infants with GI symptoms were weaned earlier than those without symptoms (P<0.04), and high-risk infants showed greater prevalence of GI symptoms, in aggregate, on a no breast milk diet than on an exclusive breast milk diet (P<0.017). Constipation, in particular, was more prevalent in high-risk infants compared with low-risk infants (P=0.01), especially on a no breast milk diet (P=0.002). High-risk infants who completed weaning earlier than 6 months showed greater prevalence of constipation (P=0.001) and abdominal distress (P=0.004) than those fully weaned after 6 months.
Conclusions:The greater prevalence of GI symptoms in high-risk infants suggests that GI dysfunction during early infant development may be a part of the ASD endophenotype. Late weaning and exclusive breast milk were associated with protection against GI symptoms in high-risk infants.
C1 [Schmid-Schoenbein, Geert W.] Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA.
[Carver, Leslie J.; Herbert, Carrie A.; Lai, Tiffany S.; McIntire, Melissa J.; Dobkins, Karen R.] Univ Calif San Diego, Dept Psychol, La Jolla, CA 92093 USA.
[Taylor, Sharon F.] Univ Calif San Diego, Dept Pediat, La Jolla, CA 92093 USA.
[Carver, Leslie J.] Univ Calif San Diego, Dept Human Dev Program, La Jolla, CA 92093 USA.
[Dobkins, Karen R.] Rady Childrens Hosp, San Diego, CA USA.
[Penn, Alexander H.; Howard, Jeffrey T.] US Army, Inst Surg Res, San Antonio, TX USA.
RP Dobkins, KR (reprint author), Univ Calif San Diego, Dept Psychol, La Jolla, CA 92093 USA.; Penn, AH (reprint author), US Army, Inst Surg Res, San Antonio, TX USA.
EM alexander.h.penn.vol@mail.mil; kdobkins@ucsd.edu
FU National Institutes of Health [NS071580]
FX This study was supported by the National Institutes of Health grant
number NS071580.
NR 48
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U1 6
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0277-2116
EI 1536-4801
J9 J PEDIATR GASTR NUTR
JI J. Pediatr. Gastroenterol. Nutr.
PD FEB
PY 2016
VL 62
IS 2
BP 317
EP 327
DI 10.1097/MPG.0000000000000907
PG 11
WC Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics
SC Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics
GA DC5WV
UT WOS:000369292300010
PM 26230900
ER
PT J
AU Carter, JR
Baker, DR
Witt, TA
Bruce, BD
AF Carter, J. Ridge
Baker, David R.
Witt, T. Austin
Bruce, Barry D.
TI Enhanced photocurrent from Photosystem I upon in vitro truncation of the
antennae chlorophyll
SO PHOTOSYNTHESIS RESEARCH
LA English
DT Article
DE Photosystem I; Hydroxyapatite; Photocurrent; Chlorophyll;
Light-harvesting complex I, II
ID CHLAMYDOMONAS-REINHARDTII; PROTEIN; COMPLEX; ENERGY; PHOTOSYNTHESIS;
HYDROXYAPATITE; EVOLUTION; ELECTRODE; SUBUNIT; CELLS
AB Current effects on climate change and dwindling fossil fuel reserves require new materials and methods to convert solar energy into a viable clean energy source. Recent progress in the direct conversion of light into photocurrent has been well documented using Photosystem I. In plants, PSI consists of a core complex and multiple light-harvesting complexes, denoted LHCI and LHCII. Most of the methods for isolating PSI from plants involve a selective, detergent solubilization from thylakoids followed by sucrose gradient density centrifugation. These processes isolate one variant of PSI with a specific ratio of Chl:P-700. In this study, we have developed a simple and potentially scalable method for isolating multiple PSI variants using Hydroxyapatite chromatography, which has been well documented in other Photosystem I isolation protocols. By varying the wash conditions, we show that it is possible to change the Chl:P-700 ratios. These different PSI complexes were cast into a PSI-Nafion-osmium polymer film that enabled their photoactivity to be measured. Photocurrent increases nearly 400 % between highly washed and untreated solutions based on equal chlorophyll content. Importantly, the mild washing conditions remove peripheral Chl and some LHCI without inhibiting the photochemical activity of PSI as suggested by SDS-PAGE analysis. This result could indicate that more P-700 could be loaded per surface area for biohybrid devices. Compared with other PSI isolations, this protocol also allows isolation of multiple PSI variants without loss of photochemical activity.
C1 [Carter, J. Ridge; Witt, T. Austin; Bruce, Barry D.] Univ Tennessee, Dept Biochem & Cellular & Mol Biol, Knoxville, TN 37996 USA.
[Baker, David R.] US Army, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA.
[Bruce, Barry D.] Univ Tennessee, Program Energy Sci & Engn, Knoxville, TN 37996 USA.
RP Bruce, BD (reprint author), Univ Tennessee, Dept Biochem & Cellular & Mol Biol, Knoxville, TN 37996 USA.; Bruce, BD (reprint author), Univ Tennessee, Program Energy Sci & Engn, Knoxville, TN 37996 USA.
EM bbruce@utk.edu
FU Army Research Laboratories (ARL) [W91 1NF-11-2-0029]; NSF-EPSCoR
[EPS-1004083]; Gibson Family Foundation
FX We would like to thank the Army Research Laboratories (ARL Contract #W91
1NF-11-2-0029), TN-SCORE sponsored by NSF-EPSCoR (EPS-1004083), and the
Gibson Family Foundation for the generous funding for this project. We
also appreciate the support and feedback provided by Khoa Nguyen,
Prakitchai Chotewutmontri, and Richard Simmerman, and Ed Wright while
conducting this research.
NR 36
TC 0
Z9 0
U1 5
U2 19
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0166-8595
EI 1573-5079
J9 PHOTOSYNTH RES
JI Photosynth. Res.
PD FEB
PY 2016
VL 127
IS 2
BP 161
EP 170
DI 10.1007/s11120-015-0162-5
PG 10
WC Plant Sciences
SC Plant Sciences
GA DC7UD
UT WOS:000369425000002
PM 26031418
ER
PT J
AU Omelchenko, IV
Shishkin, OV
Gorb, L
Leszczynski, J
AF Omelchenko, Irina V.
Shishkin, Oleg V.
Gorb, Leonid
Leszczynski, Jerzy
TI Aromaticity and conformational flexibility of five-membered
monoheterocycles: pyrrole-like and thiophene-like structures
SO STRUCTURAL CHEMISTRY
LA English
DT Article
DE Aromaticity; Five-membered heterocycles; Aromaticity indices; Aromatic
ring flexibility
ID PI-ELECTRON DELOCALIZATION; PHOSPHORUS-HETEROCYCLES; TRICOORDINATE
PHOSPHORUS; 6-MEMBERED HETEROCYCLES; QUANTITATIVE CONCEPT; RING-SYSTEMS;
PLANAR; ANALOGS; HETEROAROMATICITY; SUBSTITUENTS
AB Aromaticity and conformational flexibility of the series of five-membered monoheterocycles with group 14-16 heteroatoms, having one or two lone pairs, were studied with ab initio methods using NICS, ASE and I (5) indices. For non-planar molecules like phosphole, aromaticity of their planar transition states was also studied, and a special modification of ASE index was proposed to that end. It was found that the presence of two lone pairs is generally preferable for aromaticity of all heterocycles except CPD and silolyl dianions. Heterocycles with group 16 heteroatoms have consistently lower aromaticity compared to other groups. A lot of structures should be classified as moderate aromatic and non-aromatic. Energies of out-of-plane deformation do not correlate with other indices studied, but reveal the same qualitative trends. Generally, aromaticity of five-membered monoheterocycles depends strongly on both heteroatom type and number of lone pairs on it.
C1 [Omelchenko, Irina V.; Shishkin, Oleg V.] Natl Acad Sci Ukraine, SSI Inst Single Crystals, 60 Lenin Ave, UA-61001 Kharkov, Ukraine.
[Shishkin, Oleg V.] Kharkov Natl Univ, 4 Svobody Sq, UA-61077 Kharkov, Ukraine.
[Gorb, Leonid] Badger Tech Serv LLC, Vicksburg, MS USA.
[Leszczynski, Jerzy] US Army, Erdc, 3532 Manor Dr, Vicksburg, MS 39180 USA.
[Leszczynski, Jerzy] Jackson State Univ, Dept Chem & Biochem, Interdisciplinary Ctr Nanotox, POB 17910,1325 Lynch St, Jackson, MS 39217 USA.
RP Omelchenko, IV (reprint author), Natl Acad Sci Ukraine, SSI Inst Single Crystals, 60 Lenin Ave, UA-61001 Kharkov, Ukraine.
EM irina@xray.isc.kharkov.com
OI Omelchenko, Iryna/0000-0002-6882-6832
NR 52
TC 1
Z9 1
U1 2
U2 10
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1040-0400
EI 1572-9001
J9 STRUCT CHEM
JI Struct. Chem.
PD FEB
PY 2016
VL 27
IS 1
SI SI
BP 101
EP 109
DI 10.1007/s11224-015-0707-4
PG 9
WC Chemistry, Multidisciplinary; Chemistry, Physical; Crystallography
SC Chemistry; Crystallography
GA DC5KT
UT WOS:000369260600013
ER
PT J
AU Tinkov, OV
Ognichenko, LN
Kuz'min, VE
Gorb, LG
Kosinskaya, AP
Muratov, NN
Muratov, EN
Hill, FC
Leszczynski, J
AF Tinkov, Oleg V.
Ognichenko, Luidmila N.
Kuz'min, Victor E.
Gorb, Leonid G.
Kosinskaya, Anna P.
Muratov, Nail N.
Muratov, Eugene N.
Hill, Frances C.
Leszczynski, Jerzy
TI Computational assessment of environmental hazards of nitroaromatic
compounds: influence of the type and position of aromatic ring
substituents on toxicity
SO STRUCTURAL CHEMISTRY
LA English
DT Article
DE Nitroaromatic xenobiotics; Acute toxicity; SiRMS; Virtual screening
ID HIERARCHICAL QSAR TECHNOLOGY; SIMPLEX REPRESENTATION;
TETRAHYMENA-PYRIFORMIS; MOLECULAR-STRUCTURE; PREDICTION
AB This study summarizes the results of our recent QSAR and QSPR investigations on prediction of numerous aspects of environmental behavior of nitro compounds. In this study, we applied the QSAR/QSPR models previously developed by our group for virtual screening of energetic compounds, their precursors and other compounds containing nitro groups. To make predictions on the environmental impact of nitro compounds, we analyzed the trends in the change of the experimentally obtained and QSAR/QSPR-predicted values of aqueous solubility, lipophilicity, Ames mutagenicity, bioavailability, blood-brain barrier penetration, aquatic toxicity on T. pyriformis and acute oral toxicity on rats as a function of chemical structure of nitro compounds. All the models were developed using simplex descriptors in combination with random forest (RF) modeling techniques. We interpreted the possible environmental impact (different toxicological properties) in terms of dividing considered nitro compounds based on hydrophobic and hydrophilic characteristics and in terms of the influence of their molecular fragments that promote and interfere with toxicity. In particular, we found that, in general, the presence of amide or tertiary amine groups leads to an increase in toxicity. Also, it was predicted that compounds containing a NO2 group in the para-position of a benzene ring are more toxic than meta-isomers, which, in turn, are more toxic than ortho-isomers. In general, we concluded that hydrophobic nitroaromatic compounds, especially the ones with electron-accepting substituents, halogens and amino groups, are the most environmentally hazardous.
C1 [Tinkov, Oleg V.] TG Shevchenko State Univ, Dept Chem, Tiraspol 3300, Moldova.
[Ognichenko, Luidmila N.; Kuz'min, Victor E.; Kosinskaya, Anna P.] AV Bogatsky Phys Chem Inst NAS Ukraine, Dept Mol Struct & Chemoinformat, UA-65080 Odessa, Ukraine.
[Gorb, Leonid G.] HX5 LLC, Vicksburg, MS 39180 USA.
[Kosinskaya, Anna P.] Odessa Natl Med Univ, 2 Valikhovskiy Lane, UA-65026 Odessa, Ukraine.
[Muratov, Nail N.] Odessa Natl Polytech Univ, Dept Chem Technol, UA-65000 Odessa, Ukraine.
[Muratov, Eugene N.] Univ N Carolina, Eshelman Sch Pharm, Div Chem Biol & Med Chem, Lab Mol Modeling, Chapel Hill, NC 27599 USA.
[Hill, Frances C.] US Army, Ctr Res & Dev, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
[Leszczynski, Jerzy] Jackson State Univ, Interdisciplinary Nanotox Ctr, Dept Civil & Environm Engn, Jackson, MS 39217 USA.
RP Leszczynski, J (reprint author), Jackson State Univ, Interdisciplinary Nanotox Ctr, Dept Civil & Environm Engn, Jackson, MS 39217 USA.
EM jerzy@icnanotox.org
RI Muratov, Eugene/C-4454-2014
OI Muratov, Eugene/0000-0003-4616-7036
FU ERDC [W912HZ-13-P-0037]; National Science Foundation [OCI-1053575];
XSEDE award [DMR110088]; US National Institutes of Health [GM 096967,
GM66940]; Environmental Quality Technology Program of the United States
Army Corps of Engineers by US Army ERDC
FX We thank ERDC for financial support (grant number W912HZ-13-P-0037). The
computation time was provided by the Extreme Science and Engineering
Discovery Environment (XSEDE) by National Science Foundation Grant
Number OCI-1053575 and XSEDE award allocation Number DMR110088 and by
the Mississippi Center for Supercomputer Research. EM is grateful for
financial support from the US National Institutes of Health (GM 096967
and GM66940). The use of trade, product or firm names in this report is
for descriptive purposes only and does not imply endorsement by the US
Government. Results in this study were funded and obtained from research
conducted under the Environmental Quality Technology Program of the
United States Army Corps of Engineers by the US Army ERDC. Permission
was granted by the Chief of Engineers to publish this information. The
findings of this report are not to be construed as an official
Department of the Army position unless so designated by other authorized
documents.
NR 26
TC 1
Z9 1
U1 1
U2 7
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1040-0400
EI 1572-9001
J9 STRUCT CHEM
JI Struct. Chem.
PD FEB
PY 2016
VL 27
IS 1
SI SI
BP 191
EP 198
DI 10.1007/s11224-015-0715-4
PG 8
WC Chemistry, Multidisciplinary; Chemistry, Physical; Crystallography
SC Chemistry; Crystallography
GA DC5KT
UT WOS:000369260600021
ER
PT J
AU Sipulwa, LA
Ongus, JR
Coldren, RL
Bulimo, WD
AF Sipulwa, Lenata A.
Ongus, Juliette R.
Coldren, Rodney L.
Bulimo, Wallace D.
TI Molecular characterization of human coronaviruses and their circulation
dynamics in Kenya, 2009-2012
SO VIROLOGY JOURNAL
LA English
DT Article
DE Molecular characterization; Human coronaviruses; Prevalence; Kenya; HCOV
NL63; HCoV OC43; HCoV 229E; HCoV-HKU1
ID RESPIRATORY-TRACT INFECTION; POLYMERASE-CHAIN-REACTION; FREQUENT
DETECTION; HONG-KONG; CHILDREN; NL63; PNEUMONIA; SEQUENCE; DISEASE;
VIRUS
AB Background: Human Coronaviruses (HCoV) are a common cause of respiratory illnesses and are responsible for considerable morbidity and hospitalization across all age groups especially in individuals with compromised immunity. There are six known species of HCoV: HCoV-229E, HCoV-NL63, HCoV-HKU1, HCoV-OC43, MERS-CoV and SARS-HCoV. Although studies have shown evidence of global distribution of HCoVs, there is limited information on their presence and distribution in Kenya.
Methods: HCoV strains that circulated in Kenya were retrospectively diagnosed and molecularly characterized. A total of 417 nasopharyngeal specimens obtained between January 2009 and December 2012 from around Kenya were analyzed by a real time RT-PCR using HCoV-specific primers. HCoV-positive specimens were subsequently inoculated onto monolayers of LL-CMK2 cells. The isolated viruses were characterized by RT-PCR amplification and sequencing of the partial polymerase (pol) gene.
Results: The prevalence of HCoV infection was as follows: out of the 417 specimens, 35 (8.4 %) were positive for HCoV, comprising 10 (2.4 %) HCoV-NL63, 12 (2.9 %) HCoV-OC43, 9 (2.1 %) HCoV-HKU1, and 4 (1 %) HCoV-229E. The Kenyan HCoV strains displayed high sequence homology to the prototypes and contemporaneous strains. Evolution analysis showed that the Kenyan HCoV-OC43 and HCoV-NL63 isolates were under purifying selection. Phylogenetic evolutionary analyses confirmed the identities of three HCoV-HKU1, five HCoV-NL63, eight HCoV-OC43 and three HCoV-229E.
Conclusions: There were yearly variations in the prevalence and circulation patterns of individual HCoVs in Kenya. This paper reports on the first molecular characterization of human Coronaviruses in Kenya, which play an important role in causing acute respiratory infections among children.
C1 [Sipulwa, Lenata A.; Ongus, Juliette R.] Jomo Kenyatta Univ Agr & Technol, Coll Hlth Sci COHES, Nairobi, Kenya.
[Coldren, Rodney L.; Bulimo, Wallace D.] US Army Med Res Unit Kenya, Dept Emerging Infect Dis, POB 606, Nairobi 00621, Kenya.
[Coldren, Rodney L.; Bulimo, Wallace D.] Walter Reed Army Inst Res, Special Foreign Act, Silver Spring, MD USA.
[Bulimo, Wallace D.] Univ Nairobi, Sch Med, Dept Biochem, Nairobi, Kenya.
RP Bulimo, WD (reprint author), US Army Med Res Unit Kenya, Dept Emerging Infect Dis, POB 606, Nairobi 00621, Kenya.; Bulimo, WD (reprint author), Walter Reed Army Inst Res, Special Foreign Act, Silver Spring, MD USA.; Bulimo, WD (reprint author), Univ Nairobi, Sch Med, Dept Biochem, Nairobi, Kenya.
EM Wallace.bulimo@uonbi.ac.ke
RI Bulimo, Wallace/B-1982-2014
OI Bulimo, Wallace/0000-0001-8475-0586
FU US Armed Forces Health Surveillance Center Division of GEIS Operations
FX We thank the patients who provided specimens for this work. We also
thank the following individuals: Ms Rachel Achilla, Mr. Benjamin Opot
and Silvanos Mukunzi of the US Army Medical Research Unit-Kenya, for
laboratory management, nucleotide sequencing and analysis respectively.
Funding was provided by the US Armed Forces Health Surveillance Center
Division of GEIS Operations. The control RNA for HCoV-NL63 was provided
by Prof. James Nokes of KWTRP-Kilifi.
NR 32
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U1 1
U2 3
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1743-422X
J9 VIROL J
JI Virol. J.
PD FEB 1
PY 2016
VL 13
AR 18
DI 10.1186/s12985-016-0474-x
PG 9
WC Virology
SC Virology
GA DC6WH
UT WOS:000369359800001
PM 26833249
ER
PT J
AU Touryan, J
Kerick, SE
Ries, AJ
McDowell, K
AF Touryan, Jon
Kerick, Scott E.
Ries, Anthony J.
McDowell, Kaleb
TI Common EEG features for behavioral estimation in disparate, real-world
tasks
SO BIOLOGICAL PSYCHOLOGY
LA English
DT Article
DE EEG; Feature selection; Performance estimation; Fatigue; Learning; Real
world tasks
ID INDEPENDENT COMPONENT ANALYSIS; BRAIN-COMPUTER INTERFACE; DRIVER
FATIGUE; BLIND SEPARATION; DROWSINESS; PERFORMANCE; PREDICTION;
ALERTNESS; SPECTRUM; SYSTEM
AB In this study we explored the potential for capturing the behavioral dynamics observed in real-world tasks from concurrent measures of EEG. In doing so, we sought to develop models of behavior that would enable the identification of common cross-participant and cross-task EEG features. To accomplish this we had participants perform both simulated driving and guard duty tasks while we recorded their EEG. For each participant we developed models to estimate their behavioral performance during both tasks. Sequential forward floating selection was used to identify the montage of independent components for each model. Linear regression was then used on the combined power spectra from these independent components to generate a continuous estimate of behavior. Our results show that oscillatory processes, evidenced in EEG, can be used to successfully capture slow fluctuations in behavior in complex, multi-faceted tasks. The average correlation coefficients between the actual and estimated behavior was 0.548 +/- 0.117 and 0.701 +/- 0.154 for the driving and guard duty tasks respectively. Interestingly, through a simple clustering approach we were able to identify a number of common components, both neural and eye-movement related, across participants and tasks. We used these component clusters to quantify the relative influence of common versus participant-specific features in the models of behavior. These findings illustrate the potential for estimating complex behavioral dynamics from concurrent measures from EEG using a finite library of universal features. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license
C1 [Touryan, Jon; Kerick, Scott E.; Ries, Anthony J.; McDowell, Kaleb] US Army Res Lab, Human Res & Engn Directorate, 459 Mulberry Point Rd, Aberdeen Proving Ground, MD 21005 USA.
RP Touryan, J (reprint author), US Army Res Lab, Human Res & Engn Directorate, 459 Mulberry Point Rd, Aberdeen Proving Ground, MD 21005 USA.
EM jonathan.o.touryan.civ@mail.mil
FU U.S. Army Research Laboratory
FX Research was sponsored by the U.S. Army Research Laboratory and was
accomplished under Cooperative Agreement Number W911NF-12-2-0019. The
views and conclusions contained in this document are those of the
authors and should not be interpreted as representing the official
policies, either expressed or implied, of the Army Research Laboratory
or U.S. Government. The U.S. Government is authorized to reproduce and
distribute reprints for Government purposes notwithstanding any
copyright notation herein.
NR 53
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Z9 0
U1 2
U2 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0301-0511
EI 1873-6246
J9 BIOL PSYCHOL
JI Biol. Psychol.
PD FEB
PY 2016
VL 114
BP 93
EP 107
DI 10.1016/j.biopsycho.2015.12.009
PG 15
WC Psychology, Biological; Behavioral Sciences; Psychology; Psychology,
Experimental
SC Psychology; Behavioral Sciences
GA DC0WF
UT WOS:000368937900010
PM 26748290
ER
PT J
AU Gutteridge, CE
Major, JW
Nin, DA
Curtis, SM
Bhattacharjee, AK
Gerena, L
Nichols, DA
AF Gutteridge, Clare E.
Major, Joshua W.
Nin, Daniel A.
Curtis, Sean M.
Bhattacharjee, Apurba K.
Gerena, Lucia
Nichols, Daniel A.
TI In vitro efficacy of 2,N-bisarylated 2-ethoxyacetamides against
Plasmodium falciparum
SO BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
LA English
DT Article
DE Chalcone; 2-Ethoxyacetamide; Malaria; Plasmodium falciparum;
1,3-Diphenyl-2-propen-1-ones
ID VIVO EFFICACY; CHALCONES; LICOCHALCONE; DERIVATIVES; METABOLISM; AGENT;
ACIDS
AB Investigation of a series of 2, N-bisarylated 2-ethoxyacetamides resulted in the identification of four inhibitors 5, 20, 24, 29 with single-digit micromolar in vitro efficacy against two drug-resistant Plasmodium falciparum strains. These compounds are analogs of structurally-related 1,3-bisaryl-2-propen-1-ones (chalcones), the latter showing efficacy in vitro but not in a malaria-infected mouse. The 2, N-bisarylated 2-ethoxyacetamides (e.g., 2, 5, 20) were shown to possess significantly greater stability in the presence of metabolizing enzymes than the corresponding 1,3-bisaryl-2-propen-1-ones (e.g., 1, 3, 18). Published by Elsevier Ltd.
C1 [Gutteridge, Clare E.; Major, Joshua W.; Nin, Daniel A.; Curtis, Sean M.] US Naval Acad, Dept Chem, Annapolis, MD 21402 USA.
[Bhattacharjee, Apurba K.; Gerena, Lucia; Nichols, Daniel A.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA.
RP Gutteridge, CE (reprint author), US Naval Acad, Dept Chem, Annapolis, MD 21402 USA.
EM gutterid@usna.edu
FU Cottrell College Science Award from The Research Corporation for Science
Advancement; Military Infectious Diseases Research Program; Office of
Naval Research; Naval Academy Research Council of the United States
Naval Academy
FX We are grateful for support of this work by a Cottrell College Science
Award from The Research Corporation for Science Advancement, by the
Military Infectious Diseases Research Program, by the Office of Naval
Research, and by the Naval Academy Research Council of the United States
Naval Academy. The opinions or assertions contained herein are the
private views of the authors and are not to be construed as official, or
reflecting true views of the Department of Defense, the Department of
the Army or the Department of the Navy.
NR 23
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Z9 0
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0960-894X
EI 1464-3405
J9 BIOORG MED CHEM LETT
JI Bioorg. Med. Chem. Lett.
PD FEB 1
PY 2016
VL 26
IS 3
BP 1048
EP 1051
DI 10.1016/j.bmcl.2015.12.032
PG 4
WC Chemistry, Medicinal; Chemistry, Organic
SC Pharmacology & Pharmacy; Chemistry
GA DB8WJ
UT WOS:000368797600070
PM 26750257
ER
PT J
AU Bolton, DL
Pegu, A
Wang, KY
McGinnis, K
Nason, M
Foulds, K
Letukas, V
Schmidt, SD
Chen, XJ
Todd, JP
Lifson, JD
Rao, S
Michael, NL
Robb, ML
Mascola, JR
Koup, RA
AF Bolton, Diane L.
Pegu, Amarendra
Wang, Keyun
McGinnis, Kathleen
Nason, Martha
Foulds, Kathryn
Letukas, Valerie
Schmidt, Stephen D.
Chen, Xuejun
Todd, John Paul
Lifson, Jeffrey D.
Rao, Srinivas
Michael, Nelson L.
Robb, Merlin L.
Mascola, John R.
Koup, Richard A.
TI Human Immunodeficiency Virus Type 1 Monoclonal Antibodies Suppress Acute
Simian-Human Immunodeficiency Virus Viremia and Limit Seeding of
Cell-Associated Viral Reservoirs
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID BROADLY NEUTRALIZING ANTIBODIES; PASSIVE TRANSFER; IN-VIVO; PHASE-I;
NONHUMAN-PRIMATES; ANTIVIRAL THERAPY; CD4-BINDING SITE; RHESUS-MONKEYS;
HIV RESERVOIR; T(H)1 CELLS
AB Combination antiretroviral therapy (cART) administered shortly after human immunodeficiency virus type 1 (HIV-1) infection can suppress viremia and limit seeding of the viral reservoir, but lifelong treatment is required for the majority of patients. Highly potent broadly neutralizing HIV-1 monoclonal antibodies (MAbs) can reduce plasma viremia when administered during chronic HIV-1 infection, but the therapeutic potential of these antibodies during acute infection is unknown. We tested the ability of HIV-1 envelope glycoprotein-specific broadly neutralizing MAbs to suppress acute simian-human immunodeficiency virus (SHIV) replication in rhesus macaques. Four groups of macaques were infected with SHIV-SF162P3 and received (i) the CD4-binding-site MAb VRC01; (ii) a combination of a more potent clonal relative of VRC01 (VRC07-523) and a V3 glycan-dependent MAb (PGT121); (iii) daily cART, all on day 10, just prior to expected peak plasma viremia; or (iv) no treatment. Daily cART was initiated 11 days after MAb administration and was continued for 13 weeks in all treated animals. Over a period of 11 days after a single administration, MAb treatment significantly reduced peak viremia, accelerated the decay slope, and reduced total viral replication compared to untreated controls. Proviral DNA in lymph node CD4 T cells was also diminished after treatment with the dual MAb. These data demonstrate the virological effect of potent MAbs and support future clinical trials that investigate HIV-1-neutralizing MAbs as adjunctive therapy with cART during acute HIV-1 infection.
C1 [Bolton, Diane L.; Michael, Nelson L.; Robb, Merlin L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
[Bolton, Diane L.; Robb, Merlin L.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
[Pegu, Amarendra; Wang, Keyun; McGinnis, Kathleen; Foulds, Kathryn; Letukas, Valerie; Schmidt, Stephen D.; Chen, Xuejun; Todd, John Paul; Rao, Srinivas; Mascola, John R.; Koup, Richard A.] NIAID, Vaccine Res Ctr, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
[Nason, Martha] NIAID, Biostat Res Branch, Div Clin Res, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
[Lifson, Jeffrey D.] Leidos Biomed Res Inc, AIDS & Canc Virus Program, Frederick Natl Lab Canc Res, AIDS & Canc Virus Program, Frederick, MD USA.
[Rao, Srinivas] 640 Mem Dr, Cambridge, MA USA.
RP Bolton, DL (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
EM dbolton@hivresearch.org
RI Schmidt, Stephen/B-5398-2012
FU Henry M. Jackson Foundation for the Advancement of Military Medicine,
Inc. [W81XWH-07-2-0067]; U.S. Department of Defense (DOD)
[W81XWH-07-2-0067]; U.S. National Institute of Allergy and Infectious
Diseases; National Cancer Institute [HHSN261200800001E]
FX This work was supported by a cooperative agreement (W81XWH-07-2-0067)
between the Henry M. Jackson Foundation for the Advancement of Military
Medicine, Inc., and the U.S. Department of Defense (DOD). This research
was funded in part by the U.S. National Institute of Allergy and
Infectious Diseases and in part with federal funds under contract no.
HHSN261200800001E from the National Cancer Institute. The funders had no
role in study design, data collection and interpretation, or the
decision to submit the work for publication.
NR 48
TC 9
Z9 9
U1 1
U2 7
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0022-538X
EI 1098-5514
J9 J VIROL
JI J. Virol.
PD FEB
PY 2016
VL 90
IS 3
BP 1321
EP 1332
DI 10.1128/JVI.02454-15
PG 12
WC Virology
SC Virology
GA DC3WW
UT WOS:000369150800014
PM 26581981
ER
PT J
AU Riblett, AM
Blomen, VA
Jae, LT
Altamura, LA
Doms, RW
Brummelkamp, TR
Wojcechowskyj, JA
AF Riblett, Amber M.
Blomen, Vincent A.
Jae, Lucas T.
Altamura, Louis A.
Doms, Robert W.
Brummelkamp, Thijn R.
Wojcechowskyj, Jason A.
TI A Haploid Genetic Screen Identifies Heparan Sulfate Proteoglycans
Supporting Rift Valley Fever Virus Infection
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID HERPES-SIMPLEX-VIRUS; HUMAN XYLOSYLTRANSFERASE-II; PROTEIN LINKAGE
REGION; MOLECULAR-CLONING; ADENOASSOCIATED VIRUS; ENTRY REQUIRES;
SAUDI-ARABIA; CELL-FUSION; DC-SIGN; BIOSYNTHESIS
AB Rift Valley fever virus (RVFV) causes recurrent insect-borne epizootics throughout the African continent, and infection of humans can lead to a lethal hemorrhagic fever syndrome. Deep mutagenesis of haploid human cells was used to identify host factors required for RVFV infection. This screen identified a suite of enzymes involved in glycosaminoglycan (GAG) biogenesis and transport, including several components of the cis-oligomeric Golgi (COG) complex, one of the central components of Golgi complex trafficking. In addition, disruption of PTAR1 led to RVFV resistance as well as reduced heparan sulfate surface levels, consistent with recent observations that PTAR1-deficient cells exhibit altered Golgi complex morphology and glycosylation defects. A variety of biochemical and genetic approaches were utilized to show that both pathogenic and attenuated RVFV strains require GAGs for efficient infection on some, but not all, cell types, with the block to infection being at the level of virion attachment. Examination of other members of the Bunyaviridae family for GAG-dependent infection suggested that the interaction with GAGs is not universal among bunyaviruses, indicating that these viruses, as well as RVFV on certain cell types, employ additional unidentified virion attachment factors and/or receptors.
C1 [Riblett, Amber M.; Wojcechowskyj, Jason A.] Univ Penn, Dept Microbiol, Perelman Sch Med, Philadelphia, PA 19104 USA.
[Blomen, Vincent A.; Jae, Lucas T.; Brummelkamp, Thijn R.] Netherlands Canc Inst, Amsterdam, Netherlands.
[Altamura, Louis A.] US Army Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD USA.
[Doms, Robert W.] Childrens Hosp Philadelphia, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA.
[Brummelkamp, Thijn R.] Canc Genom Ctr, Utrecht, Netherlands.
[Wojcechowskyj, Jason A.] Gladstone Inst, San Francisco, CA USA.
[Wojcechowskyj, Jason A.] Univ Calif San Francisco, San Francisco, CA 94143 USA.
RP Wojcechowskyj, JA (reprint author), Univ Penn, Dept Microbiol, Perelman Sch Med, Philadelphia, PA 19104 USA.
EM Jason.Wojcechowskyj@ucsf.edu
FU HHS \ National Institutes of Health (NIH) [U54AI057168]; EC \ European
Research Council (ERC) [ERC-2012-StG 309634]; Nederlandse Organisatie
voor Wetenschappelijk Onderzoek (NWO) [91711316]
FX This work was funded by HHS vertical bar National Institutes of Health
(NIH) under grant U54AI057168. EC vertical bar European Research Council
(ERC) provided funding to Thijn R. Brummelkamp under grant number
ERC-2012-StG 309634. Nederlandse Organisatie voor Wetenschappelijk
Onderzoek (NWO) provided funding to Thijn R. Brummelkamp under grant
number 91711316.
NR 63
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Z9 4
U1 0
U2 2
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0022-538X
EI 1098-5514
J9 J VIROL
JI J. Virol.
PD FEB
PY 2016
VL 90
IS 3
BP 1414
EP 1423
DI 10.1128/JVI.02055-15
PG 10
WC Virology
SC Virology
GA DC3WW
UT WOS:000369150800022
PM 26581979
ER
PT J
AU Torre, C
Camacho, M
Liu, SYC
Huon, LK
Capasso, R
AF Torre, Carlos
Camacho, Macario
Liu, Stanley Yung-Chuan
Huon, Leh-Kiong
Capasso, Robson
TI Epiglottis collapse in adult obstructive sleep apnea: A systematic
review
SO LARYNGOSCOPE
LA English
DT Review
DE Obstructive Sleep Apnea; epiglottis; hypopharynx; systematic review;
surgery; snoring; positional therapy; continuous positive airway
pressure
ID POSITIVE AIRWAY PRESSURE; TRANSORAL ROBOTIC SURGERY; SIMPLE SURGICAL
REMEDY; MULTILEVEL SURGERY; ACQUIRED LARYNGOMALACIA; FLOPPY EPIGLOTTIS;
ENDOSCOPY; UVULOPALATOPHARYNGOPLASTY; THERAPY; CPAP
AB Objectives/HypothesisTo systematically review the international literature evaluating the role of the epiglottis in snoring and obstructive sleep apnea and to explore possible treatment options available.
Data SourcesPubMed, Scopus, Embase, Google Scholar, Book Citation Index-Science, CINAHL, Conference Proceedings Citation Index-Science, The Cochrane Collaboration Databases, and Web of Science.
Review MethodThe searches were performed from the first year of each database through March 5, 2015.
ResultsFourteen studies about the prevalence of epiglottis collapse in obstructive sleep apnea (OSA) were found. Most involved drug-induced sleep endoscopy studies that indirectly reported their findings about epiglottis collapse. The data suggests that the prevalence of epiglottis collapse in OSA is higher than previously described. The epiglottis has been implicated in 12% of cases of snoring, and sound originating from it has a higher pitch than palatal snoring. Continuous positive pressure (CPAP) surgery and positional therapy in the treatment of epiglottis collapse were also considered. Lateral position of the head may reduce the frequency of epiglottis collapse. With regard to CPAP, available reports suggest that it may accentuate collapse of the epiglottis. Surgery may help reduce snoring in some patients with a lax epiglottis and improve OSA in patients undergoing multilevel surgery.
ConclusionKnowledge regarding the role of the epiglottis in adult OSA and snoring patients is limited. The prevalence of this phenomenon in OSA seems to be greater than previously reported, and more research is needed to understand its role in OSA and the best way to treat it.
C1 [Torre, Carlos; Liu, Stanley Yung-Chuan; Huon, Leh-Kiong; Capasso, Robson] Stanford Univ, Med Ctr, Dept Otolaryngol Head & Neck Surg, Div Sleep Surg, Stanford, CA 94305 USA.
[Camacho, Macario] Stanford Hosp & Clin, Dept Psychiat & Behav Sci, Div Sleep Med, Stanford, CA USA.
[Torre, Carlos; Camacho, Macario; Liu, Stanley Yung-Chuan; Capasso, Robson] Stanford Univ, Sch Med, Stanford, CA 94305 USA.
[Camacho, Macario] Tripler Army Med Ctr, Dept Otolaryngol Head & Neck Surg, Div Sleep Surg & Med, Honolulu, HI 96859 USA.
[Huon, Leh-Kiong] Cathay Gen Hosp, Dept Otolaryngol Head & Neck Surg, Taipei, Taiwan.
[Huon, Leh-Kiong] Fu Jen Catholic Univ, Sch Med, Taipei, Taiwan.
RP Torre, C (reprint author), Stanford Univ, Dept Otolaryngol Head & Neck Surg, Div Sleep Surg, 450 Broadway St,Pavil B,2nd Fl, Redwood City, CA 94063 USA.
EM ctorreleon22@gmail.com
OI Camacho, Macario/0000-0001-9200-9085
NR 45
TC 9
Z9 9
U1 2
U2 5
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0023-852X
EI 1531-4995
J9 LARYNGOSCOPE
JI Laryngoscope
PD FEB
PY 2016
VL 126
IS 2
BP 515
EP 523
DI 10.1002/lary.25589
PG 9
WC Medicine, Research & Experimental; Otorhinolaryngology
SC Research & Experimental Medicine; Otorhinolaryngology
GA DC1SX
UT WOS:000368998200043
PM 26371602
ER
PT J
AU Beidleman, BA
Fulco, CS
Buller, MJ
Andrew, SP
Staab, JE
Muza, SR
AF Beidleman, Beth A.
Fulco, Charles S.
Buller, Mark J.
Andrew, Sean P.
Staab, Janet E.
Muza, Stephen R.
TI Quantitative Model of Sustained Physical Task Duration at Varying
Altitudes
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Article
DE HYPOXIA; HYPOBARIC HYPOXIA; ALGORITHM; ENDURANCE PERFORMANCE; SUBMAXIMAL
EXERCISE; UNACCLIMATIZED LOWLANDERS
ID SEA-LEVEL; ENDURANCE PERFORMANCE; EXERCISE PERFORMANCE; RUNNING
PERFORMANCE; HYPOXIA; CAPACITY; EXPOSURE; RUNNERS; MEN
AB Purpose: The objective of this study is to develop a quantitative model that can be used before ascent to altitude (ALT) to predict how much longer a sustained physical task would take for unacclimatized individuals in the early hours of exposure. Methods: Using multiple linear regression, we analyzed time-trial (TT) performance on 95 unacclimatized men (n = 83) and women (n = 12) at sea level (SL) and at an ALT ranging from 2500 to 4300 m. The TT was initiated within 4 h of ascent to ALT. The independent variables known before ascent were as follows: ALT, age, height, weight, sex, SL peak oxygen uptake, SL task duration time, and body mass index (BMI) classification (normal weight vs overweight). The dependent variable was the percent increase in TT duration from SL to ALT. Results: The most significant factor in the model was ALT (P = 0.0001), followed by BMI classification (P = 0.0009) and the interaction between BMI classification and ALT (P = 0.003). The model is as follows: percent increase in TT duration = [100 + e((-1.517+1.323 (ALT)+3.124 (BMI class)-0.769 (ALT) (BMI class))]. The percent increase in TT duration in overweight individuals was 129% greater than for normal-weight individuals at 3000 m. However, as ALT increased beyond 3000 m, the disparity between groups decreased until 4050 m where the percent increase in TT duration became greater for normal-weight individuals. Conclusions: This model provides the first quantitative estimates of the percent increase in sustained physical task duration during initial exposure to a wide range of elevations. Because only two easily obtainable factors are required as inputs for the model (ALT and BMI classification), this model can be used by many unacclimatized individuals to better plan their activities at ALT.
C1 [Beidleman, Beth A.; Fulco, Charles S.; Andrew, Sean P.; Staab, Janet E.; Muza, Stephen R.] US Army Res Inst Environm Med, Thermal & Mt Med Div, Natick, MA 01760 USA.
[Buller, Mark J.] US Army Res Inst Environm Med, Biophys & Biomed Modelling Div, Natick, MA 01760 USA.
RP Beidleman, BA (reprint author), US Army Res Inst Environm Med, Thermal & Mt Med Div, Natick, MA 01760 USA.
EM beth.a.beidleman.civ@mail.mil
FU US Army Medical Research and Materiel Command
FX Funding was provided by the US Army Medical Research and Materiel
Command
NR 38
TC 1
Z9 1
U1 2
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD FEB
PY 2016
VL 48
IS 2
BP 323
EP 330
DI 10.1249/MSS.0000000000000768
PG 8
WC Sport Sciences
SC Sport Sciences
GA DB8JX
UT WOS:000368764100018
PM 26339725
ER
PT J
AU Turney, SG
Ahmed, M
Chandrasekar, I
Wysolmerski, RB
Goeckeler, ZM
Rioux, RM
Whitesides, GM
Bridgman, PC
AF Turney, Stephen G.
Ahmed, Mostafa
Chandrasekar, Indra
Wysolmerski, Robert B.
Goeckeler, Zoe M.
Rioux, Robert M.
Whitesides, George M.
Bridgman, Paul C.
TI Nerve growth factor stimulates axon outgrowth through negative
regulation of growth cone actomyosin restraint of microtubule advance
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Article
ID MYOSIN-II ACTIVITY; CELL-ADHESION MOLECULE; END-BINDING-PROTEIN; F-ACTIN
FLOW; NEURITE OUTGROWTH; COMPARTMENTALIZED CULTURES; SYMPATHETIC
NEURONS; FLUORESCENT PROTEIN; RETROGRADE FLOW; TRKA RECEPTOR
AB Nerve growth factor (NGF) promotes growth, differentiation, and survival of sensory neurons in the mammalian nervous system. Little is known about how NGF elicits faster axon outgrowth or how growth cones integrate and transform signal input to motor output. Using cultured mouse dorsal root ganglion neurons, we found that myosin II (MII) is required for NGF to stimulate faster axon outgrowth. From experiments inducing loss or gain of function of MII, specific MII isoforms, and vinculin-dependent adhesion-cytoskeletal coupling, we determined that NGF causes decreased vinculin-dependent actomyosin restraint of microtubule advance. Inhibition of MII blocked NGF stimulation, indicating the central role of restraint in directed outgrowth. The restraint consists of myosin IIB- and IIA-dependent processes: retrograde actin network flow and transverse actin bundling, respectively. The processes differentially contribute on laminin-1 and fibronectin due to selective actin tethering to adhesions. On laminin-1, NGF induced greater vinculin-dependent adhesion-cytoskeletal coupling, which slowed retrograde actin network flow (i.e., it regulated the molecular clutch). On fibronectin, NGF caused inactivation of myosin IIA, which negatively regulated actin bundling. On both substrates, the result was the same: NGF-induced weakening of MII-dependent restraint led to dynamic microtubules entering the actin-rich periphery more frequently, giving rise to faster elongation.
C1 [Turney, Stephen G.] Harvard Univ, Ctr Brain Sci, Cambridge, MA 02138 USA.
[Turney, Stephen G.] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA.
[Rioux, Robert M.; Whitesides, George M.] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA.
[Ahmed, Mostafa; Chandrasekar, Indra; Bridgman, Paul C.] Washington Univ, Sch Med, Dept Neurosci, St Louis, MO 63110 USA.
[Wysolmerski, Robert B.; Goeckeler, Zoe M.] W Virginia Univ, Sch Med, Dept Neurobiol & Anat, Morgantown, WV 26506 USA.
[Ahmed, Mostafa] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
[Chandrasekar, Indra] Sanford Res, Sanford Childrens Hlth Res Ctr, Sioux Falls, SD 57104 USA.
[Rioux, Robert M.] Penn State Univ, Dept Chem Engn, University Pk, PA 16802 USA.
RP Bridgman, PC (reprint author), Washington Univ, Sch Med, Dept Neurosci, St Louis, MO 63110 USA.
EM bridgmap@pcg.wustl.edu
FU National Institutes of Health [R21 MH081260, R21 EB9776, HL-090937,
P20RR016440, 1 F32 NS60356-01]; Bakewell Neuroimaging Core, an imaging
facility by Bakewell Family Foundation; National Institutes of Health
Neuroscience Blueprint Interdisciplinary Center Core Grant [P30
(NS057105)]; Department of Molecular and Cellular Biology, Harvard
University; National Science Foundation [ECS-0335765]
FX This research was supported by grants to P.C.B. from National Institutes
of Health (R21 MH081260, R21 EB9776) and in part by the Bakewell
Neuroimaging Core, an imaging facility supported by the Bakewell Family
Foundation and National Institutes of Health Neuroscience Blueprint
Interdisciplinary Center Core Grant P30 (NS057105) to Washington
University. S.G.T. receives support from Jeff Lichtman and the
Department of Molecular and Cellular Biology, Harvard University. R.B.W.
was supported by grants from the National Institutes of Health
(HL-090937, P20RR016440). The fabrication of microfluidics devices was
performed in part at the Center for Nanoscale Systems, a member of the
National Nanotechnology Infrastructure Network, which is supported by
the National Science Foundation under award ECS-0335765. The Center for
Nanoscale Systems is part of the Faculty of Arts and Sciences, Harvard
University. R.M.R. received a postdoctoral fellowship (1 F32 NS60356-01)
from the National Institutes of Health.
NR 66
TC 2
Z9 3
U1 2
U2 12
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
EI 1939-4586
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PD FEB 1
PY 2016
VL 27
IS 3
BP 500
EP 517
DI 10.1091/mbc.E15-09-0636
PG 18
WC Cell Biology
SC Cell Biology
GA DC3NY
UT WOS:000369127200009
PM 26631553
ER
PT J
AU Mrozek, RA
Berg, MC
Gold, CS
Leighliter, B
Morton, JT
Lenhart, JL
AF Mrozek, Randy A.
Berg, Michael C.
Gold, Christopher S.
Leighliter, Brad
Morton, Jeffrey T.
Lenhart, Joseph L.
TI Highly compliant shape memory polymer gels for tunable damping and
reversible adhesion
SO SMART MATERIALS AND STRUCTURES
LA English
DT Article
DE shape memory polymer; reversible damping; polymer gel
ID BIOMEDICAL APPLICATIONS; MECHANICAL-PROPERTIES; GRANULAR MEDIA;
ACRYLIC-ACID; HYDROGELS; NETWORKS; BEHAVIOR; ROBOT; SURFACES; RHEOLOGY
AB Materials that can dynamically change their properties to better adapt to the local environment have potential utility in robotics, aerospace, and coatings. For some of these applications, most notably robotics, it is advantageous for these responsive materials to be highly compliant in an effort to provide dynamic changes in adhesion and mechanical damping within a broad temperature operational environment. In this report, non-aqueous, highly compliant shape-memory polymer gels are developed by incorporating a low density of chemical cross-links into a physically cross-linked thermoplastic elastomer gel. Chemical cross-linkers were evaluated by varying there size and degree of functionality to determine the impact on the mechanical and adhesive properties. As a result of the chemical cross-linking, the gels exhibit modulus plateaus around room temperature and at elevated temperatures above 100 degrees C, where the thermoplastic elastomer gel typically melts. The materials were designed so that moduli in the plateaued regions were above and below the Dahlquist criteria of 4 x 10(4) Pa, respectively, where materials with a modulus below this value typically exhibit an increase in adhesion. The shape memory polymer gels were also integrated into fiber-reinforced composites to determine the temperature-dependent changes in mechanical damping. It is anticipated that this work will provide insight into materials design to provide dynamic changes in adhesion and damping to improve robotic appendage manipulation and platform mobility.
C1 [Mrozek, Randy A.; Berg, Michael C.; Gold, Christopher S.; Leighliter, Brad; Lenhart, Joseph L.] US Army Res Lab, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21904 USA.
[Morton, Jeffrey T.] Florida A&M Florida State Univ, 2003 Levy Ave, Tallahassee, FL 32310 USA.
RP Mrozek, RA; Lenhart, JL (reprint author), US Army Res Lab, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21904 USA.
EM randy.a.mrozek.civ@mail.mil; joseph.l.lenhart.civ@mail.mil
NR 50
TC 0
Z9 0
U1 12
U2 38
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0964-1726
EI 1361-665X
J9 SMART MATER STRUCT
JI Smart Mater. Struct.
PD FEB
PY 2016
VL 25
IS 2
AR 025004
DI 10.1088/0964-1726/25/2/025004
PG 10
WC Instruments & Instrumentation; Materials Science, Multidisciplinary
SC Instruments & Instrumentation; Materials Science
GA DB9CP
UT WOS:000368814100006
ER
PT J
AU Torres, OB
Antoline, JFG
Li, FY
Jalah, R
Jacobson, AE
Rice, KC
Alving, CR
Matyas, GR
AF Torres, Oscar B.
Antoline, Joshua F. G.
Li, Fuying
Jalah, Rashmi
Jacobson, Arthur E.
Rice, Kenner C.
Alving, Carl R.
Matyas, Gary R.
TI A simple nonradioactive method for the determination of the binding
affinities of antibodies induced by hapten bioconjugates for drugs of
abuse
SO ANALYTICAL AND BIOANALYTICAL CHEMISTRY
LA English
DT Article
DE Heroinhapten; Competition ELISA; Equilibrium dialysis; UPLC/MS/MS;
Apparent dissociation constant (K-d); Antibody affinity
ID LINKED IMMUNOSORBENT ASSAY; SIMPLE CHEMICAL-COMPOUNDS; MINIMAL
CROSS-REACTIVITY; DIACETYLMORPHINE HEROIN; MONOCLONAL-ANTIBODIES;
MASS-SPECTROMETRY; MORPHINE; RADIOIMMUNOASSAY; VACCINE; SPECIFICITY
AB The accurate analytical measurement of binding affinities of polyclonal antibody in sera to heroin, 6-acetylmorphine (6-AM), and morphine has been a challenging task. A simple nonradioactive method that uses deuterium-labeled drug tracers and equilibrium dialysis (ED) combined with ultra performance liquid chromatography/tandem mass spectrometry (UPLC/MS/MS) to measure the apparent dissociation constant (K (d)) of antibodies to 6-AM and morphine is described. The method can readily detect antibodies with K (d) in the low nanomolar range. Since heroin is rapidly degraded in sera, esterase inhibitors were included in the assay, greatly reducing heroin hydrolysis. MS/MS detection directly measured the heroin in the assay after overnight ED, thereby allowing the quantitation of % bound heroin in lieu of K (d) as an alternative measurement to assess heroin binding to polyclonal antibody sera. This is the first report that utilizes a solution-based assay to quantify heroin-antibody binding without being confounded by the presence of 6-AM and morphine and to measure K (d) of polyclonal antibody to 6-AM. Hapten surrogates 6-AcMorHap, 6-PrOxyHap, MorHap, DiAmHap, and DiPrOxyHap coupled to tetanus toxoid (TT) were used to generate high affinity antibodies to heroin, 6-AM, and morphine. In comparison to competition ED-UPLC/MS/MS which gave K (d) values in the nanomolar range, the commonly used competition enzyme-linked immunosorbent assay (ELISA) measured the 50 % inhibition concentration (IC50) values in the micromolar range. Despite the differences in K (d) and IC50 values, similar trends in affinities of hapten antibodies to heroin, 6-AM, and morphine were observed by both methods. Competition ED-UPLC/MS/MS revealed that among the five TT-hapten bioconjugates, TT-6-AcMorHap and TT-6-PrOxyHap induced antibodies that bound heroin, 6-AM, and morphine. In contrast, TT-MorHap induced antibodies that poorly bound heroin, while TT-DiAmHap and TT-DiPrOxyHap induced antibodies either did not bind or poorly bound to heroin, 6-AM, and morphine. This simple and nonradioactive method can be extended to other platforms, such as oxycodone, cocaine, nicotine, and methamphetamine for the selection of the lead hapten design during substance abuse vaccine development.
C1 [Torres, Oscar B.; Jalah, Rashmi; Alving, Carl R.; Matyas, Gary R.] Walter Reed Army Inst Res, Lab Adjuvant & Antigen Res, US Mil HIV Res Program, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
[Torres, Oscar B.; Jalah, Rashmi] Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, 6720A Rockledge Dr, Bethesda, MD 20817 USA.
[Antoline, Joshua F. G.; Li, Fuying; Jacobson, Arthur E.; Rice, Kenner C.] NIDA, Drug Design & Synth Sect, Mol Targets & Medicat Discovery Branch, NIH,US Dept HHS, 9800 Med Dr, Bethesda, MD 20892 USA.
[Antoline, Joshua F. G.; Li, Fuying; Jacobson, Arthur E.; Rice, Kenner C.] NIAAA, NIH, 9800 Med Dr, Bethesda, MD 20892 USA.
[Li, Fuying] WuXi AppTec Shanghai Co Ltd, 288 FuTe Rd, Shanghai 200131, Peoples R China.
RP Matyas, GR (reprint author), Walter Reed Army Inst Res, Lab Adjuvant & Antigen Res, US Mil HIV Res Program, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM gmatyas@hivresearch.org
OI Matyas, Gary/0000-0002-2074-2373
FU Intramural NIH HHS; NIDA NIH HHS [1DP1DA034787-01, DP1 DA034787]
NR 50
TC 1
Z9 1
U1 5
U2 19
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1618-2642
EI 1618-2650
J9 ANAL BIOANAL CHEM
JI Anal. Bioanal. Chem.
PD FEB
PY 2016
VL 408
IS 4
BP 1191
EP 1204
DI 10.1007/s00216-015-9223-z
PG 14
WC Biochemical Research Methods; Chemistry, Analytical
SC Biochemistry & Molecular Biology; Chemistry
GA DB7TZ
UT WOS:000368720600016
PM 26677020
ER
PT J
AU Voloshinov, VB
Gupta, N
Kulakova, LA
Khorkin, VS
Melekh, BT
Knyazev, GA
AF Voloshinov, V. B.
Gupta, N.
Kulakova, L. A.
Khorkin, V. S.
Melekh, B. T.
Knyazev, G. A.
TI Investigation of acousto-optic properties of tellurium-based glasses for
infrared applications
SO JOURNAL OF OPTICS
LA English
DT Article
DE acousto-optics; tellurium-based glasses; infrared; optical transmission;
figure of merit; modulation; deflection
ID 10.6 MU-M; TUNABLE FILTER; CRYSTAL; PERFORMANCE; HG2CL2
AB We examined the physical properties of infrared optical glasses composed of tellurium, germanium, selenium, sulfur and silicon. In particular, we measured optical, acoustic and photoelastic parameters of the following alloy compounds: germanium-selenium-tellurium (Ge-Se- Te), germanium-selenium-sulfur-tellurium (Ge-Se-S-Te), germanium-silicon-tellurium (Ge-Si-Te) and silicon-tellurium (Si-Te). Like single-crystal tellurium, the glasses demonstrate good acousto-optic (AO) diffraction efficiency and have reasonable optical transparency in a wide spectral region covering wavelengths from 1.5 to 20 mu m. The optical, acoustic and photoelastic properties of the tellurium-based compounds were measured using infrared lamp sources of radiation as well as He-Ne and CO2 lasers. In this paper, we report on the optical, acoustic and photoelastic parameters of a selection of these compounds and discuss the advantages and disadvantages of using these glasses for AO device applications. We also present the measured characteristics of an AO cell fabricated in a Si20Te80 glass material which exhibited high optical uniformity and long-term chemical stability.
C1 [Voloshinov, V. B.; Khorkin, V. S.; Knyazev, G. A.] Moscow MV Lomonosov State Univ, Fac Phys, Moscow 199991, Russia.
[Gupta, N.] US Army, Res Lab, Adelphi, MD 20783 USA.
[Kulakova, L. A.; Melekh, B. T.] AF Ioffe Phys Tech Inst, St Petersburg 194021, Russia.
RP Voloshinov, VB (reprint author), Moscow MV Lomonosov State Univ, Fac Phys, Moscow 199991, Russia.
EM volosh@phys.msu.ru; neelam.gupta.civ@mail.mil; L.Kulakova@mail.ioffe.ru
FU [RUP1-31167-MO-13]
FX The research in Russia was supported by the grant RUP1-31167-MO-13
issued by CRDF Global.
NR 28
TC 1
Z9 1
U1 2
U2 10
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 2040-8978
EI 2040-8986
J9 J OPTICS-UK
JI J. Opt.
PD FEB
PY 2016
VL 18
IS 2
AR 025402
DI 10.1088/2040-8978/18/2/025402
PG 9
WC Optics
SC Optics
GA DB1IO
UT WOS:000368262000020
ER
PT J
AU Haenisch, F
Cooper, JD
Reif, A
Kittel-Schneider, S
Steiner, J
Leweke, FM
Rothermundt, M
van Beveren, NJM
Crespo-Facorro, B
Niebuhr, DW
Cowan, DN
Weber, NS
Yolken, RH
Penninxi, BWJH
Bahn, S
AF Haenisch, Frieder
Cooper, Jason D.
Reif, Andreas
Kittel-Schneider, Sarah
Steiner, Johann
Leweke, F. Markus
Rothermundt, Matthias
van Beveren, Nico J. M.
Crespo-Facorro, Benedicto
Niebuhr, David W.
Cowan, David N.
Weber, Natalya S.
Yolken, Robert H.
Penninxi, Brenda W. J. H.
Bahn, Sabine
TI Towards a blood-based diagnostic panel for bipolar disorder
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Bipolar disorder; Multiplex immunoassay; Biomarker; Differential
diagnosis; Diagnostic test
ID MULTIPLE-SCLEROSIS LESIONS; MATRIX METALLOPROTEINASES; EXPRESSION;
SCHIZOPHRENIA; DYSFUNCTION; BIOMARKERS; IMBALANCE; MONOCYTES; BARRIER;
SYSTEM
AB Background: Bipolar disorder (BD) is a costly, devastating and life shortening mental disorder that is often misdiagnosed, especially on initial presentation. Misdiagnosis frequently results in ineffective treatment. We investigated the utility of a biomarker panel as a diagnostic test for BD.
Methods and findings: We performed a meta-analysis of eight case-control studies to define a diagnostic biomarker panel for BD. After validating the panel on established BD patients, we applied it to undiagnosed BD patients. We analysed 249 BD, 122 pre-diagnostic BD, 75 pre-diagnostic schizophrenia and 90 first onset major depression disorder (MDD) patients and 371 controls. The biomarker panel was identified using ten-fold cross-validation with lasso regression applied to the 87 analytes available across the meta-analysis studies.
We identified 20 protein analytes with excellent predictive performance [area under the curve (AUC) >= 0.90]. Importantly, the panel had a good predictive performance (AUC 0.84) to differentiate 12 misdiagnosed BD patients from 90 first onset MDD patients, and a fair to good predictive performance (AUC 0.79) to differentiate between 110 pre-diagnostic BD patients and 184 controls. We also demonstrated the disease specificity of the panel.
Conclusions: An early and accurate diagnosis has the potential to delay or even prevent the onset of BD. This study demonstrates the potential utility of a biomarker panel as a diagnostic test for BD. (C) 2015 The Authors. Published by Elsevier Inc.
C1 [Haenisch, Frieder; Cooper, Jason D.; Bahn, Sabine] Univ Cambridge, Dept Chem Engn & Biotechnol, Cambridge, England.
[Reif, Andreas; Kittel-Schneider, Sarah] Goethe Univ Hosp Frankfurt, Dept Psychiat Psychosomat Med & Psychotherapy, Frankfurt, Germany.
[Steiner, Johann] Univ Magdeburg, Dept Psychiat Psychotherapy & Psychosomat Med, D-39106 Magdeburg, Germany.
[Leweke, F. Markus] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Mannheim, Germany.
[Rothermundt, Matthias] Univ Munster, Dept Psychiat, Munster, Germany.
[van Beveren, Nico J. M.] Erasmus Univ, Med Ctr, Dept Psychiat, Rotterdam, Netherlands.
[Crespo-Facorro, Benedicto] Univ Cantabria, IDIVAL, Univ Hosp Marques de Valdecilla, CIBERSAM,Dept Psychiat, E-39005 Santander, Spain.
[Niebuhr, David W.; Cowan, David N.; Weber, Natalya S.] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Yolken, Robert H.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA.
[Penninxi, Brenda W. J. H.] Vrije Univ Amsterdam, Med Ctr, EMGO Inst, Dept Psychiat, Amsterdam, Netherlands.
RP Bahn, S (reprint author), Univ Cambridge, Dept Chem Engn & Biotechnol, Cambridge, England.
EM sb209@cam.ac.uk
OI Haenisch, Frieder/0000-0001-7961-4467; Kittel-Schneider,
Sarah/0000-0003-3057-6150
FU Stanley Medical Research Institute [07R-1888]; Netherlands Organisation
for Health Research and Development (Zon-Mw) [10-000-1002]; VU
University Medical Center; Leiden University Medical Center; University
Medical Center Groningen; Stanley Medical Research Institute; US
Department of the Army
FX We gratefully acknowledge support by the Stanley Medical Research
Institute (no. 07R-1888). The infrastructure for the NESDA study
(www.nesda.nl) has been funded through the Geestkracht program of the
Netherlands Organisation for Health Research and Development (Zon-Mw,
grant number 10-000-1002) and participating universities (VU University
Medical Center, Leiden University Medical Center, University Medical
Center Groningen). DNC, DWN and NSW efforts were funded by the Stanley
Medical Research Institute and the US Department of the Army. The
funding organizations had no role in the design and conduct of the
study; the collection, management, analysis, and interpretation of the
data; or the preparation or approval of the manuscript. The views
expressed are those of the authors and should not be construed to
represent the positions of the funding bodies including the US
Department of the Army or Department of Defense.
NR 43
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Z9 5
U1 3
U2 12
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD FEB
PY 2016
VL 52
BP 49
EP 57
DI 10.1016/j.bbi.2015.10.001
PG 9
WC Immunology; Neurosciences
SC Immunology; Neurosciences & Neurology
GA DB2DB
UT WOS:000368317400008
PM 26441135
ER
PT J
AU Vidal-Dorsch, DE
Bay, SM
Moore, S
Layton, B
Mehinto, AC
Vulpe, CD
Brown-Augustine, M
Loguinov, A
Poynton, H
Garcia-Reyero, N
Perkins, EJ
Escalon, L
Denslow, ND
Cristina, CDR
Doan, T
Shukradas, S
Bruno, J
Brown, L
Van Agglen, G
Jackman, P
Bauer, M
AF Vidal-Dorsch, Doris E.
Bay, Steven M.
Moore, Shelly
Layton, Blythe
Mehinto, Alvine C.
Vulpe, Chris D.
Brown-Augustine, Marianna
Loguinov, Alex
Poynton, Helen
Garcia-Reyero, Natalia
Perkins, Edward J.
Escalon, Lynn
Denslow, Nancy D.
Cristina, Colli-Dula R.
Doan, Tri
Shukradas, Shweta
Bruno, Joy
Brown, Lorraine
Van Agglen, Graham
Jackman, Paula
Bauer, Megan
TI Ecotoxicogenomics: Microarray interlaboratory comparability
SO CHEMOSPHERE
LA English
DT Article
DE Ecotoxicogenomics; Microarray; Gene expression; Intercalibration; Inter-
and intra-laboratory reproducibility; Amphipod
ID TOXICOGENOMICS; PLATFORMS; ISSUES
AB Transcriptomic analysis can complement traditional ecotoxicology data by providing mechanistic insight, and by identifying sub-lethal organismal responses and contaminant classes underlying observed toxicity. Before transcriptomic information can be used in monitoring and risk assessment, it is necessary to determine its reproducibility and detect key steps impacting the reliable identification of differentially expressed genes. A custom 15K-probe microarray was used to conduct transcriptomics analyses across six laboratories with estuarine amphipods exposed to cyfluthrin-spiked or control sediments (10 days). Two sample types were generated, one consisted of total RNA extracts (Ex) from exposed and control samples (extracted by one laboratory) and the other consisted of exposed and control whole body amphipods (WB) from which each laboratory extracted RNA. Our findings indicate that gene expression microarray results are repeatable. Differentially expressed data had a higher degree of repeatability across all laboratories in samples with similar RNA quality (Ex) when compared to WB samples with more variable RNA quality. Despite such variability a subset of genes were consistently identified as differentially expressed across all laboratories and sample types. We found that the differences among the individual laboratory results can be attributed to several factors including RNA quality and technical expertise, but the overall results can be improved by following consistent protocols and with appropriate training. Published by Elsevier Ltd.
C1 [Vidal-Dorsch, Doris E.; Bay, Steven M.; Moore, Shelly; Layton, Blythe; Mehinto, Alvine C.] Southern Calif Coastal Water Res Project, Costa Mesa, CA 92626 USA.
[Vulpe, Chris D.; Brown-Augustine, Marianna; Loguinov, Alex] Univ Calif Berkeley, Berkeley, CA 94720 USA.
[Poynton, Helen] Univ Massachusetts, Boston, MA 02125 USA.
[Garcia-Reyero, Natalia] Mississippi State Univ, Starkville, MS USA.
[Garcia-Reyero, Natalia; Perkins, Edward J.; Escalon, Lynn] US Army Engn Res & Dev Ctr, Vicksburg, MS USA.
[Denslow, Nancy D.; Cristina, Colli-Dula R.] Univ Florida, Gainesville, FL USA.
[Cristina, Colli-Dula R.] Inst Politecn Nacl, Ctr Invest & Estudios Avanzados, Merida, Mexico.
[Doan, Tri; Shukradas, Shweta] Agilent Technol, Santa Clara, CA USA.
[Shukradas, Shweta] Strand Sci Intelligence Inc, San Francisco, CA USA.
[Bruno, Joy; Brown, Lorraine; Van Agglen, Graham] Environm Canada, N Vancouver, BC, Canada.
[Jackman, Paula; Bauer, Megan] Environm Canada, Moncton, NB, Canada.
RP Vidal-Dorsch, DE (reprint author), Southern Calif Coastal Water Res Project, 3535 Harbor Blvd Suite 110, Costa Mesa, CA 92626 USA.
EM dorisv@sccwrp.org
FU Environment Canada for Minister of Environment [1301230]
FX The authors wish to acknowledge the efforts of their staff and those of
collaborating organizations, which have been instrumental to the success
of this project. We thank SCCWRP staff Darrin Greenstein, Patricia
Gonzalez, Fernando Vargas and Mary-Caitlin Jordan for conducting the
laboratory exposures and coordinating sample storage and transfer. The
authors would like to thank Agilent staff for all their support in this
project particularly, Sharon Henne and the Genomics staff. This study
was funded in part by Environment Canada for the Minister of the
Environment (Contribution No. 1301230). In kind support for this project
was also provided by all the participating laboratories.
NR 22
TC 2
Z9 2
U1 4
U2 13
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0045-6535
EI 1879-1298
J9 CHEMOSPHERE
JI Chemosphere
PD FEB
PY 2016
VL 144
BP 193
EP 200
DI 10.1016/j.chemosphere.2015.08.019
PG 8
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA DA4MQ
UT WOS:000367774400026
PM 26363320
ER
PT J
AU Mark, N
Arthur, J
Dontsova, K
Brusseau, M
Taylor, S
AF Mark, Noah
Arthur, Jennifer
Dontsova, Katerina
Brusseau, Mark
Taylor, Susan
TI Adsorption and attenuation behavior of 3-nitro-1,2,4-triazol-5-one (NTO)
in eleven soils
SO CHEMOSPHERE
LA English
DT Article
DE NTO; Soil adsorption; Insensitive munitions; Energetic materials
ID CONSTITUENTS 2,4-DINITROANISOLE DNAN; INSENSITIVE MUNITIONS
FORMULATIONS; ORGANIC-CARBON; CLAY-MINERALS; DISSOLUTION; SORPTION;
NITROGUANIDINE; EXPLOSIVES; ACID; TNT
AB NTO (3-nitro-1,2,4-triazol-5-one) is one of the new explosive compounds used in insensitive munitions (IM) developed to replace traditional explosives, TNT and RDX. Data on NTO fate and transport is needed to determine its environmental behavior and potential for groundwater contamination. We conducted a series of kinetic and equilibrium batch experiments to characterize the fate of NTO in soils and the effect of soil geochemical properties on NTO-soil interactions. A set of experiments was also conducted using sterilized soils to evaluate the contribution of biodegradation to NTO attenuation. Measured pH values for NTO solutions decreased from 5.98+/-0.13 to 3.50+/-0.06 with increase in NTO concentration from 0.78 to 100 mg L-1. Conversely, the pH of soil suspensions was not significantly affected by NTO in this concentration range. NTO experienced minimal adsorption, with measured adsorption coefficients being less than 1 cm(3) g(-1) for all studied soils. There was a highly significant inverse relationship between the measured NTO adsorption coefficients and soil pH (P = 0.00011), indicating the role of NTO and soil charge in adsorption processes. In kinetic experiments, 1st order transformation rate constant estimates ranged between 0.0004 h(-1) and 0.0142 h(-1) (equivalent to half-lives of 72 and 2 d, respectively), and correlated positively with organic carbon in the soil. Total attenuation of NTO was higher in untreated versus sterilized samples, suggesting that NTO was being biodegraded. The information presented herein can be used to help evaluate NTO potential for natural attenuation in soils. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Mark, Noah; Arthur, Jennifer; Dontsova, Katerina; Brusseau, Mark] Univ Arizona, Dept Soil Water & Environm Sci, Tucson, AZ 85721 USA.
[Dontsova, Katerina] Univ Arizona, Biosphere 2, Tucson, AZ 85721 USA.
[Taylor, Susan] US Army Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA.
RP Dontsova, K (reprint author), Univ Arizona, Marshall Bldg,Room 523,845 N,Pk Ave, Tucson, AZ 85721 USA.
EM dontsova@email.arizona.edu
FU Strategic Environmental Research and Development Program, SERDP
[ER-2220]
FX This work was funded by the Strategic Environmental Research and
Development Program, SERDP, project ER-2220. We are grateful to Anthony
Di Stasio and Erika Rivera, US Army Armament Research, Development and
Engineering Center (ARDEC), Picatinny Arsenal for providing NTO; Bonnie
M. Packer, Rosa Gwinn, Lisa DeGrazia, Bethany Keller, Jessica Milose,
Amibeth Sheridan, Laurie Stenberg, Sarah Gettier, Army National
Guard-Environmental Directorate and URS Corporation, Germantown, MD and
Mike Heitmann, CH2M HILL Englewood, CO for collecting soils used in the
experiments on Army National Guard installations.
NR 41
TC 6
Z9 6
U1 8
U2 36
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0045-6535
EI 1879-1298
J9 CHEMOSPHERE
JI Chemosphere
PD FEB
PY 2016
VL 144
BP 1249
EP 1255
DI 10.1016/j.chemosphere.2015.09.101
PG 7
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA DA4MQ
UT WOS:000367774400156
PM 26473550
ER
PT J
AU Brett-Major, DM
Frick, KD
Malia, JA
Hakre, S
Okulicz, JF
Beckett, CG
Jagodinski, LL
Forgione, MA
Gould, PL
Harrison, SA
Murray, CK
Rentas, FJ
Armstrong, AW
Hayat, AM
Pacha, LA
Dawson, P
Eick-Cost, AA
Maktabi, HH
Michael, NL
Cersovsky, SB
Peel, SA
Scott, PT
AF Brett-Major, David M.
Frick, Kevin D.
Malia, Jennifer A.
Hakre, Shilpa
Okulicz, Jason F.
Beckett, Charmagne G.
Jagodinski, Linda L.
Forgione, Michael A.
Gould, Philip L.
Harrison, Stephen A.
Murray, Clinton K.
Rentas, Francisco J.
Armstrong, Adam W.
Hayat, Aatif M.
Pacha, Laura A.
Dawson, Peter
Eick-Cost, Angelia A.
Maktabi, Hala H.
Michael, Nelson L.
Cersovsky, Steven B.
Peel, Sheila A.
Scott, Paul T.
TI Costs and Consequences: Hepatitis C Seroprevalence in the Military and
Its Impact on Potential Screening Strategies
SO HEPATOLOGY
LA English
DT Article
ID TASK-FORCE RECOMMENDATION; VIRUS-INFECTION; UNITED-STATES; WHOLE-BLOOD;
SOFOSBUVIR; REGIMENS
AB Knowledge of the contemporary epidemiology of hepatitis C viral (HCV) infection among military personnel can inform potential Department of Defense screening policy. HCV infection status at the time of accession and following deployment was determined by evaluating reposed serum from 10,000 service members recently deployed to combat operations in Iraq and Afghanistan in the period 2007-2010. A cost model was developed from the perspective of the Department of Defense for a military applicant screening program. Return on investment was based on comparison between screening program costs and potential treatment costs avoided. The prevalence of HCV antibody-positive and chronic HCV infection at accession among younger recently deployed military personnel born after 1965 was 0.98/1000 (95% confidence interval 0.45-1.85) and 0.43/1000 (95% confidence interval 0.12-1.11), respectively. Among these, service-related incidence was low; 64% of infections were present at the time of accession. With no screening, the cost to the Department of Defense of treating the estimated 93 cases of chronic HCV cases from a single year's accession cohort was $9.3 million. Screening with the HCV antibody test followed by the nucleic acid test for confirmation yielded a net annual savings and a $3.1 million dollar advantage over not screening. Conclusions: Applicant screening will reduce chronic HCV infection in the force, result in a small system costs savings, and decrease the threat of transfusion-transmitted HCV infection in the battlefield blood supply and may lead to earlier diagnosis and linkage to care; initiation of an applicant screening program will require ongoing evaluation that considers changes in the treatment cost and practice landscape, screening options, and the epidemiology of HCV in the applicant/accession and overall force populations.
C1 [Brett-Major, David M.] Naval Med Res Ctr, Infect Dis Directorate, Silver Spring, MD USA.
[Brett-Major, David M.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD USA.
[Frick, Kevin D.] Johns Hopkins Univ, Carey Business Sch, Baltimore, MD USA.
[Malia, Jennifer A.] US Mil HIV Res Program, Walter Reed Army Inst Res, Silver Spring, MD USA.
[Hakre, Shilpa] Henry M Jackson Fdn, US Mil HIV Res Program, Bethesda, MD USA.
[Okulicz, Jason F.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA.
[Beckett, Charmagne G.] Navy Bloodborne Infect Management Ctr, Bethesda, MD USA.
[Gould, Philip L.] US Air Force Surg Gen Off, Falls Church, VA USA.
[Rentas, Francisco J.] Armed Serv Blood Program Off, Falls Church, VA USA.
[Rentas, Francisco J.] US Army Blood Program, Falls Church, VA USA.
Navy Med Res Unit 6, Lima, Peru.
[Armstrong, Adam W.] US Army Publ Hlth Ctr Provisional, Aberdeen Proving Ground, MD USA.
[Hayat, Aatif M.; Pacha, Laura A.; Cersovsky, Steven B.] Emmes Corp, Rockville, MD USA.
[Dawson, Peter] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD USA.
[Eick-Cost, Angelia A.] Henry M Jackson Fdn, Bethesda, MD USA.
[Eick-Cost, Angelia A.] Vet Adm, Off Med Inspector, Washington, DC USA.
RP Brett-Major, DM (reprint author), NMRC, 503 Robert Grant Ave, Silver Spring, MD USA.
EM david.m.brett.mil@mail.mil
FU OCONUS Contingency Operations funds from the US Department of Defense
FX Supported by OCONUS Contingency Operations funds from the US Department
of Defense.
NR 22
TC 1
Z9 1
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0270-9139
EI 1527-3350
J9 HEPATOLOGY
JI Hepatology
PD FEB
PY 2016
VL 63
IS 2
BP 398
EP 407
DI 10.1002/hep.28303
PG 10
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA EL6VS
UT WOS:000394761100011
PM 26481723
ER
PT J
AU Coleman, SP
Tschopp, MA
Weinberger, CR
Spearot, DE
AF Coleman, Shawn P.
Tschopp, Mark A.
Weinberger, Christopher R.
Spearot, Douglas E.
TI Bridging atomistic simulations and experiments via virtual diffraction:
understanding homophase grain boundary and heterophase interface
structures
SO JOURNAL OF MATERIALS SCIENCE
LA English
DT Article
ID STRUCTURE-ENERGY CORRELATION; X-RAY-DIFFRACTION; FCC METALS;
MOLECULAR-DYNAMICS; TILT BOUNDARIES; GOLD; ALUMINUM; ANGLE; DEFORMATION;
NUCLEATION
AB Virtual diffraction is a computational technique that enables a synergistic coupling between experiments and atomistic simulations, which can help to elucidate nanoscale structure-property relationships. The research objective herein is to highlight recent advances in the use of virtual diffraction as a method to study the geometry and structure of homophase grain boundaries and heterophase interfaces with direct experimental validation. Virtual selected area diffraction patterns for two types of boundaries-homophase Al twist grain boundaries and heterophase Al2O3/Al interfaces-are created without a priori assumption of the periodic interface structure by computing diffraction intensities across high-resolution, 3-D reciprocal space meshes. In this work, computed diffraction patterns clearly identify Al grain boundary misorientation angles, reveal subsidiary peaks created by the dislocation arrays within select Al grain boundaries, and allow experimental validation of the minimum energy orientation relationship for the Al2O3/Al interface. Due to its advanced implementation, virtual diffraction characterization used throughout this work can be easily extended providing routes for similar analysis and experimental validation of atomistic simulations.
C1 [Coleman, Shawn P.; Tschopp, Mark A.] US Army, Res Lab, Aberdeen, MD 21005 USA.
[Weinberger, Christopher R.] Drexel Univ, Dept Mech Engn & Mech, Philadelphia, PA 19104 USA.
[Spearot, Douglas E.] Univ Arkansas, Dept Mech Engn, Fayetteville, AR 72701 USA.
RP Coleman, SP (reprint author), US Army, Res Lab, Aberdeen, MD 21005 USA.
EM shawn.p.coleman8.ctr@mail.mil
OI Tschopp, Mark/0000-0001-8471-5035
FU U.S. Army Research Laboratory; National Science Foundation [0954505,
ACI1053575]; 21st Century Professorship in Mechanical Engineering at the
University of Arkansas
FX SPC acknowledges support by an appointment to Postdoctoral Fellowship at
the U.S. Army Research Laboratory, administered by the Oak Ridge
Institute for Science and Education. SPC and DES acknowledge support of
the National Science Foundation under Grant #0954505. Additional support
is provided by the 21st Century Professorship in Mechanical Engineering
at the University of Arkansas. Simulations were run using the Extreme
Science and Engineering Discovery Environment (XSEDE), which is
supported by National Science Foundation Grant number ACI1053575.
NR 45
TC 1
Z9 1
U1 3
U2 9
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0022-2461
EI 1573-4803
J9 J MATER SCI
JI J. Mater. Sci.
PD FEB
PY 2016
VL 51
IS 3
BP 1251
EP 1260
DI 10.1007/s10853-015-9087-9
PG 10
WC Materials Science, Multidisciplinary
SC Materials Science
GA DA2GE
UT WOS:000367612500008
ER
PT J
AU Vahedifard, F
Robinson, JD
Mason, GL
Howard, IL
Priddy, JD
AF Vahedifard, Farshid
Robinson, Joe D.
Mason, George L.
Howard, Isaac L.
Priddy, Jody D.
TI Mobility algorithm evaluation using a consolidated database developed
for wheeled vehicles operating on dry sands
SO JOURNAL OF TERRAMECHANICS
LA English
DT Article
DE Mobility; Sand; Drawbar pull; Motion resistance; Sinkage; Vehicle
Terrain Interface (VTI); Database
AB A substantial number of laboratory and field tests have been conducted to assess performance of various wheel designs in loose soils. However, there is no consolidated database which includes data from several sources. In this study, a consolidated database was created on tests conducted with wheeled vehicles operating in loose dry sand to evaluate existing soil mobility algorithms. The database included wheels of different diameters, widths, heights, and inflation pressures, operating under varying loading conditions. Nine technical reports were identified containing 5253 records, based on existing archives of laboratory and field tests of wheels operating in loose soils. The database structure was assembled to include traction performance parameters such as drawbar pull, torque, traction, motion resistance, sinkage, and wheel slip. Once developed, the database was used to evaluate and support validation of closed form solutions for these variables in the Vehicle Terrain Interface (VTI) model. The correlation between predicted and measured traction performance parameters was evaluated. Comparison of the predicted versus measured performance parameters suggests that the closed form solutions within the VTI model are functional but can be further improved to provide more accurate predictions for off-road vehicle performance. (C) 2015 ISTVS. Published by Elsevier Ltd. All rights reserved.
C1 [Vahedifard, Farshid; Robinson, Joe D.; Howard, Isaac L.] Mississippi State Univ, Dept Civil & Environm Engn, Mississippi State, MS 39762 USA.
[Vahedifard, Farshid; Robinson, Joe D.; Mason, George L.] Mississippi State Univ, Ctr Adv Vehicular Syst CAVS, Mississippi State, MS 39762 USA.
[Priddy, Jody D.] US Army Engineer Res & Dev Ctr ERDC, Vicksburg, MS 39180 USA.
RP Vahedifard, F (reprint author), Mississippi State Univ, Dept Civil & Environm Engn, Mississippi State, MS 39762 USA.
EM farshid@cee.msstate.edu; jdr418@msstate.edu;
George.L.Mason.PE@engineer.com; ilhoward@cee.msstate.edu;
Jody.D.Priddy@erdc.dren.mil
FU U.S. Government [W15QKN-13-9-0001]
FX This effort was sponsored by the U.S. Government under Other Transaction
number W15QKN-13-9-0001 between the Consortium for Energy, Environment
and Demilitarization, and the Government. The U.S. Government is
authorized to reproduce and distribute reprints for Governmental
purposes notwithstanding any copyright notation thereon. The views and
conclusions contained herein are those of the authors and should not be
interpreted as necessarily representing the official policies or
endorsements, either expressed or implied, of the U.S. Government. The
authors would like to thank Levi Weeks and Clinton Carlisle for their
assistance in extracting data from various reports and assembling the
database. This paper is based on the work conducted under Task 12:
Mobility Modeling for Soils. Roger King, Director of the Center for
Advanced Vehicular Systems (CAVS) at Mississippi State University, was
principal investigator for W15QKN-13-9-0001 and Farshid Vahedifard was
the lead for Task 12.
NR 32
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U1 1
U2 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-4898
EI 1879-1204
J9 J TERRAMECHANICS
JI J. Terramech.
PD FEB
PY 2016
VL 63
BP 13
EP 22
DI 10.1016/j.jterra.2015.10.002
PG 10
WC Engineering, Environmental
SC Engineering
GA DA4MP
UT WOS:000367774300002
ER
PT J
AU Scenna, R
Gupta, AK
AF Scenna, Richard
Gupta, Ashwani K.
TI Partial oxidation of JP8 in a well-insulated distributed reactor
SO FUEL PROCESSING TECHNOLOGY
LA English
DT Article
DE Fuel reforming via partial oxidation; JP8; Non-catalytic fuel reforming;
Distributed reaction regime; Hydrogen production
ID FUELS
AB Low temperature fuel reforming via partial oxidation in a distributed reactor has shown superior performances compared to other lower temperature approaches. Previous results and literature indicated higher reactor temperatures to yield superior results. The well-insulated reactor developed incorporated elements of the low temperature reactor design. The syngas obtained was of better quality in terms of gas species component present and the syngas heating value than that reported previously from a non-catalytic reformer. The syngas composition consisted of 19.2% hydrogen and 20.8% carbon monoxide and these values are higher than the previously reported data. Lower series of hydrocarbons (acetylene and propane) were only detected in trace amounts (less than 15 ppm). Elevated reactor temperatures promoted the dissociation of lower series of hydrocarbons (methane, acetylene, and ethylene), which provided additional syngas formation. The gas species concentrations obtained approached that of catalytic reforming. Flame regime was determined through numerical diagnostics. As reaction regime became less distributed with higher injection temperature, reformate quality was adversely impacted. The mitigation of thermal losses from the well-insulated reactor promoted superior reformer efficiency by allowing the reactor to achieve conditions not possible in low temperature reactors. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Scenna, Richard] US Army Res, Dev & Engn Command, CERDEC, CPI, Adelphi, MD USA.
[Gupta, Ashwani K.] Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA.
RP Gupta, AK (reprint author), Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA.
EM akgupta@umd.edu
FU United States Army's Research Development Engineering Command (RDECOM)
Independent Laboratory Innovative Research (ILIR) program; US Army
Communication Electronic Research Directorate Engineering Command
(CERDEC) Command Power Integration (CPI) directorate; Reaction Design
for the Chemkin
FX The authors acknowledge the support of the United States Army's Research
Development Engineering Command (RDECOM) Independent Laboratory
Innovative Research (ILIR) program and US Army Communication Electronic
Research Directorate Engineering Command (CERDEC) Command Power
Integration (CPI) directorate. The authors also gratefully acknowledge
the help and support provided by Reaction Design for the Chemkin code
used here.
NR 21
TC 2
Z9 2
U1 2
U2 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-3820
EI 1873-7188
J9 FUEL PROCESS TECHNOL
JI Fuel Process. Technol.
PD FEB
PY 2016
VL 142
BP 174
EP 181
DI 10.1016/j.fuproc.2015.10.014
PG 8
WC Chemistry, Applied; Energy & Fuels; Engineering, Chemical
SC Chemistry; Energy & Fuels; Engineering
GA CZ4XV
UT WOS:000367107300020
ER
PT J
AU Martin, RF
AF Martin, Ronald F.
TI Alternative Considerations for Surgical Training and Funding
SO SURGICAL CLINICS OF NORTH AMERICA
LA English
DT Article
DE Surgical training; Funding; Graduate medical education; Alternatives
ID EDUCATION
AB Since the late 1880s, surgical residency programs have existed in forms that are similar to our current models. Many important variations have been introduced overtime. On aggregate this system has worked remarkably well; though as economic, demographic, and cultural changes continue to evolve, one must wonder if we were to change our models, how might we do that and what reasoning could we use. This article's focus is to take a stratospheric view of what could be done, particularly in the United States, rather than characterize what happens in other countries with other health economic systems.
C1 [Martin, Ronald F.] Marshfield Clin Fdn Med Res & Educ, Marshfield, WI 54449 USA.
[Martin, Ronald F.] St Josephs Hosp, Marshfield, WI 54449 USA.
[Martin, Ronald F.] Univ Wisconsin, Sch Med & Publ Hlth, Dept Surg, Madison, WI 53726 USA.
[Martin, Ronald F.] US Army Reserve, Med Corps, Worcester, MA USA.
RP Martin, RF (reprint author), Marshfield Clin Fdn Med Res & Educ, 1000 North Oak Ave, Marshfield, WI 54449 USA.
EM rmartin@yorkhospital.com
NR 7
TC 0
Z9 0
U1 0
U2 2
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0039-6109
EI 1558-3171
J9 SURG CLIN N AM
JI Surg. Clin.-North Am.
PD FEB
PY 2016
VL 96
IS 1
BP 35
EP +
DI 10.1016/j.suc.2015.09.002
PG 13
WC Surgery
SC Surgery
GA CZ5DV
UT WOS:000367123600006
PM 26612018
ER
PT J
AU Lanzillo, NA
O'Regan, TP
Nayak, SK
AF Lanzillo, Nicholas A.
O'Regan, Terrance P.
Nayak, Saroj K.
TI Band structure modulation in MoS2 multilayers and heterostructures
through electric field and strain
SO COMPUTATIONAL MATERIALS SCIENCE
LA English
DT Article
DE MoS2; Heterostructures; Electric field; Band gap
ID TRANSITION-METAL DICHALCOGENIDES; MONOLAYER MOS2
AB We use density functional theory to investigate the effect of finite external electric fields along with strain on the electronic structure of MoS2 multilayers and heterostructures composed of MoS2/MoSe2/MoS2 and MoS2/WS2/MoS2. We find that the presence of an electric field decreases the values of both direct and indirect band gaps, in agreement with earlier works. However, when either compressive or tensile strain is applied to the system the strength of the coupling between the electric field and direct band gap is increased while the coupling strength between the electric field and the indirect band gap is decreased. In contrast, in the heterostructures the coupling with the direct band gap remains unchanged while the coupling with indirect band gap is decreased. Taken together, these results show rich behavior of the electric field effects in MoS2 multilayers and heterostructures. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Lanzillo, Nicholas A.; Nayak, Saroj K.] Rensselaer Polytech Inst, Dept Phys Appl Phys & Astron, Troy, NY 12180 USA.
[Lanzillo, Nicholas A.] Rensselaer Polytech Inst, Rensselaer Exploratory Ctr Cheminformat Res, Troy, NY 12180 USA.
[O'Regan, Terrance P.] US Army, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20723 USA.
[Nayak, Saroj K.] Indian Inst Technol, Sch Basic Sci, Bhubaneswar 751007, Orissa, India.
RP Lanzillo, NA (reprint author), Rensselaer Polytech Inst, Rensselaer Exploratory Ctr Cheminformat Res, 110 8th St, Troy, NY 12180 USA.
FU Army Research Lab Multiscale Multidisciplinary Modeling of Electronic
Materials (MSME) Collaborative Research Alliance (CRA); Indo-US Forum on
Science and Technology; Centre of Novel Energy Materials (CENEMA) -
Ministry of Human Resource Development (MHRD), India
FX Future work will investigate the effect of applied electric fields on
thicker layers of MoS2 as well as other transition metal
dichalcogenide systems using GW quasiparticle-based approaches. This
work used computational resources provided by the Computational Center
for Nanotechnology Innovations (CCNI) at Rensselaer Polytechnic
Institute. The authors acknowledge support by the Army Research Lab
Multiscale Multidisciplinary Modeling of Electronic Materials (MSME)
Collaborative Research Alliance (CRA) and the Indo-US Forum on Science
and Technology. The authors also acknowledge support from the Centre of
Novel Energy Materials (CENEMA) funded by the Ministry of Human Resource
Development (MHRD), India.
NR 43
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Z9 1
U1 16
U2 92
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0927-0256
EI 1879-0801
J9 COMP MATER SCI
JI Comput. Mater. Sci.
PD FEB
PY 2016
VL 112
BP 377
EP 382
DI 10.1016/j.commatsci.2015.11.007
PN A
PG 6
WC Materials Science, Multidisciplinary
SC Materials Science
GA CX9VE
UT WOS:000366053000048
ER
PT J
AU Files, BT
Marathe, AR
AF Files, Benjamin T.
Marathe, Amar R.
TI A regression method for estimating performance in a rapid serial visual
presentation target detection task
SO JOURNAL OF NEUROSCIENCE METHODS
LA English
DT Article
DE RSVP; Hit rate; False alarm rate; Response time; Simulation
ID COUPLED COMPUTER VISION; ATTENTIONAL BLINK; IDENTIFICATION;
CLASSIFICATION; RECOGNITION; PICTURES
AB Background: Estimating target detection performance in the rapid serial visual presentation (RSVP) target detection paradigm can be challenging when the inter-stimulus interval is small relative to the variability in human response time. The challenge arises because assigning a particular response to the correct image cannot be done with certainty. Existing solutions to this challenge establish a heuristic for assigning responses to images and thereby determining which responses are hits and which are false alarms.
New method: We developed a regression-based method for estimating hit rate and false alarm rate that corrects for expected errors in a likelihood-based assignment of responses to stimuli.
Results: Simulations show that this regression method results in an unbiased and accurate estimate of target detection performance.
Comparison with existing methods: The regression method had lower estimation error compared to three existing methods, and in contrast to the existing methods, the errors made by the regression method do not depend strongly on the true values of hit rate and false alarm rate. The most commonly used existing method performed well when simulated performance was nearly perfect, but not when behavioral error rates increased.
Conclusions: Based on its better estimation of hit rate and false alarm rate, the regression method proposed here would seem the best choice when estimating the hit rate and false alarm rate is the primary interest. (C) 2015 The Authors. Published by Elsevier B.V.
C1 [Files, Benjamin T.; Marathe, Amar R.] Army Res Lab, Human Res & Engn Directorate, 459 Mulberry Point Rd, Aberdeen Proving Ground, MD 21005 USA.
RP Files, BT (reprint author), Army Res Lab, Human Res & Engn Directorate, 459 Mulberry Point Rd, Aberdeen Proving Ground, MD 21005 USA.
EM benjamin.files.ctr@mail.mil
FU U.S. Army Research Laboratory under a Director's Strategic Research
Initiative entitled Heterogeneous Systems for Information Variable
Environments (HIVE)
FX This project was supported by The U.S. Army Research Laboratory under a
Director's Strategic Research Initiative entitled Heterogeneous Systems
for Information Variable Environments (HIVE)and an appointment to the
U.S. Army Research Laboratory Postdoctoral Fellowship program
administered by the Oak Ridge Associated Universities through a
cooperative agreement with the U.S. Army Research Laboratory. The views
and conclusions contained in this document are those of the authors and
should not be interpreted as representing the official policies, either
expressed or implied, of the Army Research Laboratory or U.S.
Government. The U.S. Government is authorized to reproduce and
distribute reprints for Government purposes notwithstanding any
copyright notation herein.
NR 26
TC 0
Z9 0
U1 2
U2 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0270
EI 1872-678X
J9 J NEUROSCI METH
JI J. Neurosci. Methods
PD JAN 30
PY 2016
VL 258
BP 114
EP 123
DI 10.1016/j.jneumeth.2015.11.003
PG 10
WC Biochemical Research Methods; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA DC4OB
UT WOS:000369199100012
PM 26561772
ER
PT J
AU Perkins, MW
Wong, B
Tressler, J
Coggins, A
Rodriguez, A
Devorak, J
Sciuto, AM
AF Perkins, Michael W.
Wong, Benjamin
Tressler, Justin
Coggins, Andrew
Rodriguez, Ashley
Devorak, Jennifer
Sciuto, Alfred M.
TI Assessment of inhaled acute ammonia-induced lung injury in rats
SO INHALATION TOXICOLOGY
LA English
DT Article
DE lung injury; respiratory toxicology; toxic industrial chemical;
inhalation exposure; Ammonia; pulmonary edema
ID ACUTE INHALATION TOXICITY; BRONCHOALVEOLAR LAVAGE FLUID; EXPOSURE;
NEUROTOXICITY; PHOSGENE; THERAPY; MODEL; ANIMALS; DISEASE; SOMAN
AB This study examined acute toxicity and lung injury following inhalation exposure to ammonia. Male Sprague-Dawley rats (300-350 g) were exposed to 9000, 20 000, 23 000, 26 000, 30 000 or 35 000 ppm of ammonia for 20 min in a custom head-out exposure system. The exposure atmosphere, which attained steady state within 3 min for all ammonia concentrations, was monitored and verified using a Fourier transform infrared spectroscopy (FTIR) gas analyzer. Animals exposed to ammonia resulted in dose-dependent increases in observed signs of intoxication, including increased chewing and licking, ocular irritation, salivation, lacrimation, oronasal secretion and labored breathing. The LCt(50) of ammonia within this head-out inhalation exposure model was determined by probit analysis to be 23 672 ppm (16 489 mg/m(3)) for the 20 min exposure in male rats. Exposure to 20 000 or 23 000 ppm of ammonia resulted in significant body weight loss 24-h post-exposure. Lung edema increased in all ammonia-exposed animal groups and was significant following exposure to 9000 ppm. Bronchoalveolar fluid (BALF) protein concentrations significantly increased following exposure to 20 000 or 23 000 ppm of ammonia in comparison to controls. BAL cell (BALC) death and total cell counts increased in animals exposed to 20 000 or 23 000 ppm of ammonia in comparison to controls. Differential cell counts of white blood cells, neutrophils and platelets from blood and BALF were significantly increased following exposure to 23 000 ppm of ammonia. The following studies describe the validation of a head-out inhalation exposure model for the determination of acute ammonia-induced toxicity; this model will be used for the development and evaluation of potential therapies that provide protection against respiratory and systemic toxicological effects.
C1 [Perkins, Michael W.; Wong, Benjamin; Tressler, Justin; Coggins, Andrew; Rodriguez, Ashley; Devorak, Jennifer; Sciuto, Alfred M.] US Army Med Res Inst Chem Def, Analyt Toxicol Div, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA.
RP Perkins, MW (reprint author), US Army Med Res Inst Chem Def, Analyt Toxicol Div, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA.
EM michael.w.perkins1.civ@mail.mil
FU National Institute of Health (NIH) Countermeasures Against Chemical
Threats (CounterACT) program [IAA: AOD14021]; Oak Ridge Associated
Universities; Geneva Foundation
FX Special thanks to the National Institute of Health (NIH) Countermeasures
Against Chemical Threats (CounterACT) program for support (IAA:
AOD14021). AR is supported by the Oak Ridge Associated Universities. AC
is supported by the Geneva Foundation. The experimental protocol was
approved by the Animal Care and Use Committee at the United States Army
Medical Research Institute of Chemical Defense and all procedures were
conducted in accordance with the principles stated in the Guide for the
Care and Use of Laboratory Animals and the Animal Welfare Act of 1966
(P.L. 89-544), as amended. The views expressed in this article are those
of the author(s) and do not reflect the official policy of the
Department of Army, Department of Defense, or the U.S. Government.
NR 41
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U1 2
U2 7
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0895-8378
EI 1091-7691
J9 INHAL TOXICOL
JI Inhal. Toxicol.
PD JAN 28
PY 2016
VL 28
IS 2
BP 71
EP 79
DI 10.3109/08958378.2015.1136715
PG 9
WC Toxicology
SC Toxicology
GA DF8GN
UT WOS:000371595600003
PM 26821737
ER
PT J
AU Mackenchery, K
Valisetty, RR
Namburu, RR
Stukowski, A
Rajendran, AM
Dongare, AM
AF Mackenchery, Karoon
Valisetty, Ramakrishna R.
Namburu, Raju R.
Stukowski, Alexander
Rajendran, Arunachalam M.
Dongare, Avinash M.
TI Dislocation evolution and peak spall strengths in single crystal and
nanocrystalline Cu
SO JOURNAL OF APPLIED PHYSICS
LA English
DT Article
ID VOID GROWTH; DUCTILE FRACTURE; MAXIMUM STRENGTH; DYNAMIC FAILURE;
STRAIN-RATE; COPPER; NUCLEATION; BEHAVIOR; METALS; SIMULATION
AB The dynamic evolution and interaction of defects under the conditions of shock loading in single crystal and nanocrystalline Cu are investigated using a series of large-scale molecular dynamics simulations for an impact velocity of 1 km/s. Four stages of defect evolution are identified during shock simulations that result in deformation and failure. These stages correspond to: the initial shock compression (I); the propagation of the compression wave (II); the propagation and interaction of the reflected tensile wave (III); and the nucleation, growth, and coalescence of voids (IV). The effect of the microstructure on the evolution of defect densities during these four stages is characterized and quantified for single crystal Cu as well as nanocrystalline Cu with an average grain size of 6 nm, 10 nm, 13 nm, 16 nm, 20 nm, and 30 nm. The evolution of twin densities during the shock propagation is observed to vary with the grain size of the system and affects the spall strength of the metal. The grain sizes of 6 nm and 16 nm are observed to have peak values for the twin densities and a spall strength that is comparable with the single crystal Cu. (C) 2016 AIP Publishing LLC.
C1 [Mackenchery, Karoon; Dongare, Avinash M.] Univ Connecticut, Dept Mat Sci & Engn, Storrs, CT 06269 USA.
[Mackenchery, Karoon; Dongare, Avinash M.] Univ Connecticut, Inst Mat Sci, Storrs, CT 06269 USA.
[Valisetty, Ramakrishna R.; Namburu, Raju R.] US Army Res Lab, Computat & Informat Sci Directorate, Aberdeen Proving Ground, MD 21005 USA.
[Stukowski, Alexander] Tech Univ Darmstadt, Inst Mat Sci, D-64287 Darmstadt, Germany.
[Rajendran, Arunachalam M.] Univ Mississippi, Dept Mech Engn, 201-B Carrier Hall, University, MS 38677 USA.
RP Dongare, AM (reprint author), Univ Connecticut, Dept Mat Sci & Engn, Storrs, CT 06269 USA.; Dongare, AM (reprint author), Univ Connecticut, Inst Mat Sci, Storrs, CT 06269 USA.
EM dongare@uconn.edu
OI Stukowski, Alexander/0000-0001-6750-3401; Dongare,
Avinash/0000-0003-3189-3588
FU NSF CMMI [1454547]; Student Research Participation Program at the U.S.
Army Research Laboratory (USARL)
FX This work acknowledges the support from NSF CMMI under Grant No. 1454547
and K.M. acknowledges the support in part from the Student Research
Participation Program at the U.S. Army Research Laboratory (USARL)
administered by the Oak Ridge Institute for Science and Education
through an interagency agreement between the U.S. Department of Energy
and USARL. Computational support through the Department of Defense
(DOD), High Performance Computing Modernization Program (HPCMP), and the
Booth Engineering Center for Advanced Technology (BECAT) is also
acknowledged.
NR 51
TC 4
Z9 4
U1 7
U2 22
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0021-8979
EI 1089-7550
J9 J APPL PHYS
JI J. Appl. Phys.
PD JAN 28
PY 2016
VL 119
IS 4
AR 044301
DI 10.1063/1.4939867
PG 11
WC Physics, Applied
SC Physics
GA DD4ME
UT WOS:000369896300015
ER
PT J
AU Wang, RL
Biales, AD
Garcia-Reyero, N
Perkins, EJ
Villeneuve, DL
Ankley, GT
Bencic, DC
AF Wang, Rong-Lin
Biales, Adam D.
Garcia-Reyero, Natalia
Perkins, Edward J.
Villeneuve, Daniel L.
Ankley, Gerald T.
Bencic, David C.
TI Fish connectivity mapping: linking chemical stressors by their
mechanisms of action-driven transcriptomic profiles
SO BMC GENOMICS
LA English
DT Article
DE Fish; Gene expression profiles; Connectivity mapping
ID MINNOWS PIMEPHALES-PROMELAS; GENE-EXPRESSION SIGNATURES; BISPHENOL-A;
ANDROGEN RECEPTOR; RISK-ASSESSMENT; HYDROCARBON RECEPTOR; MOLECULAR
TARGET; ECOLOGICAL RISK; FATHEAD MINNOW; ZEBRAFISH
AB Background: A very large and rapidly growing collection of transcriptomic profiles in public repositories is potentially of great value to developing data-driven bioinformatics applications for toxicology/ecotoxicology. Modeled on human connectivity mapping (Cmap) in biomedical research, this study was undertaken to investigate the utility of an analogous Cmap approach in ecotoxicology. Over 3500 zebrafish (Danio rerio) and fathead minnow (Pimephales promelas) transcriptomic profiles, each associated with one of several dozen chemical treatment conditions, were compiled into three distinct collections of rank-ordered gene lists (ROGLs) by species and microarray platforms. Individual query signatures, each consisting of multiple gene probes differentially expressed in a chemical condition, were used to interrogate the reference ROGLs.
Results: Informative connections were established at high success rates within species when, as defined by their mechanisms of action (MOAs), both query signatures and ROGLs were associated with the same or similar chemicals. Thus, a simple query signature functioned effectively as an exposure biomarker without need for a time-consuming process of development and validation. More importantly, a large reference database of ROGLs also enabled a query signature to cross-interrogate other chemical conditions with overlapping MOAs, leading to novel groupings and subgroupings of seemingly unrelated chemicals at a finer resolution. This approach confirmed the identities of several estrogenic chemicals, as well as a polycyclic aromatic hydrocarbon and a neuro-toxin, in the largely uncharacterized water samples near several waste water treatment plants, and thus demonstrates its future potential utility in real world applications.
Conclusions: The power of Cmap should grow as chemical coverages of ROGLs increase, making it a framework easily scalable in the future. The feasibility of toxicity extrapolation across fish species using Cmap needs more study, however, as more gene expression profiles linked to chemical conditions common to multiple fish species are needed.
C1 [Wang, Rong-Lin; Biales, Adam D.; Bencic, David C.] US EPA, Exposure Methods & Measurements Div, Natl Exposure Res Lab, 26 W Martin Luther King Dr,MS 587, Cincinnati, OH 45268 USA.
[Garcia-Reyero, Natalia; Perkins, Edward J.] US Army Corps Engineers, US Army Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
[Villeneuve, Daniel L.; Ankley, Gerald T.] US EPA, Midcontinent Ecol Div, Natl Hlth & Environm Effects Res Lab, 6201 Congdon Blvd, Duluth, MN 55804 USA.
RP Wang, RL (reprint author), US EPA, Exposure Methods & Measurements Div, Natl Exposure Res Lab, 26 W Martin Luther King Dr,MS 587, Cincinnati, OH 45268 USA.
EM Wang.Rong-Lin@epa.gov
FU US Environmental Protection Agency (USEPA); U.S. Army Environmental
Quality and Installations program; U.S. Army [BAA 11-4838]
FX Funding for zebrafish exposures and microarray analysis was provided by
US Environmental Protection Agency (USEPA). The U.S. Army Environmental
Quality and Installations program and U.S. Army (grant BAA 11-4838)
provided funding for fathead minnow microarrays analysis. The funders
had no role in study design, data collection and analysis, or
preparation of the manuscript. We thank Lynn Escalon and Xin Guan in the
Environmental Laboratory, US Army Engineer Research and Development
Center for microarray data generation. The internal technical review was
conducted by Mark Nelms at the National Health and Environmental Effects
Research Laboratory, USEPA. The views expressed in this article are
those of the authors and do not necessarily represent the views or
policies of the USEPA. The manuscript has been approved for publication
by USEPA and US Army Corps Chief of Engineers.
NR 62
TC 0
Z9 0
U1 5
U2 18
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2164
J9 BMC GENOMICS
JI BMC Genomics
PD JAN 28
PY 2016
VL 17
AR 84
DI 10.1186/s12864-016-2406-y
PG 20
WC Biotechnology & Applied Microbiology; Genetics & Heredity
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA DC0GH
UT WOS:000368894700001
PM 26822894
ER
PT J
AU Zhang, ZJ
Nguyen, HTH
Miller, SA
Ploskonka, AM
DeCoste, JB
Cohen, SM
AF Zhang, Zhenjie
Ha Thi Hoang Nguyen
Miller, Stephen A.
Ploskonka, Ann M.
DeCoste, Jared B.
Cohen, Seth M.
TI Polymer-Metal-Organic Frameworks (polyMOFs) as Water Tolerant Materials
for Selective Carbon Dioxide Separations
SO JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Article
ID SUPRAMOLECULAR POLYMERS; BLOCK-COPOLYMERS; ADSORPTION; GEL;
METALLOPOLYMERS; STABILITY; CAPTURE
AB Recently, polymer-metal-organic frameworks (polyMOFs) were reported as a new class of hybrid porous materials that combine advantages of both organic polymers and crystalline MOFs. Herein, we report a bridging coligand strategy to prepare new types of polyMOFs, demonstrating that polyMOFs are compatible with additional MOF architectures besides that of the earlier reported IRMOF-1 type polyMOF. Gas sorption studies revealed that these polyMOF materials exhibited relatively high CO2 sorption but very low N-2 sorption, making them promising materials for CO2/N-2 separations. Moreover, these polyMOFs demonstrated exceptional water stability attributed to the hydrophobicity of polymer ligands as well as the cross-linking of the polymer chains within the MOF.
C1 [Zhang, Zhenjie; Cohen, Seth M.] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA.
[Ha Thi Hoang Nguyen] Univ Florida, Dept Chem, George & Josephine Butler Lab Polymer Res, Gainesville, FL 32611 USA.
[Ploskonka, Ann M.; DeCoste, Jared B.] Leidos Inc, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA.
[DeCoste, Jared B.] US Army Res Dev & Engn Command, Edgewood Chem Biol Ctr, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA.
RP Cohen, SM (reprint author), Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA.
EM scohen@ucsd.edu
OI Cohen, Seth/0000-0002-5233-2280
FU Department of Energy, Office of Basic Energy Sciences, Division of
Materials Science and Engineering [DE-FG02-08ER46519]; National Science
Foundation [CHE-1305794]; Joint Science and Technology Office for
Chemical Biological Defense (JSTO-CBD) [BA07PRO104]
FX This work was supported by a grant from the Department of Energy, Office
of Basic Energy Sciences, Division of Materials Science and Engineering
under Award No. DE-FG02-08ER46519 (S.M.C.) and the National Science
Foundation under Award No. CHE-1305794 (S.A.M.). We also acknowledge the
Joint Science and Technology Office for Chemical Biological Defense
(JSTO-CBD) for funding under Project Number BA07PRO104.
NR 34
TC 22
Z9 22
U1 75
U2 255
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0002-7863
J9 J AM CHEM SOC
JI J. Am. Chem. Soc.
PD JAN 27
PY 2016
VL 138
IS 3
BP 920
EP 925
DI 10.1021/jacs.5b11034
PG 6
WC Chemistry, Multidisciplinary
SC Chemistry
GA DC2KA
UT WOS:000369044400037
PM 26709448
ER
PT J
AU Rodriguez, RI
Jordon, JB
Allison, PG
Rushing, T
Garcia, L
AF Rodriguez, R. I.
Jordon, J. B.
Allison, P. G.
Rushing, T.
Garcia, L.
TI Low-cycle fatigue of dissimilar friction stir welded aluminum alloys
SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES
MICROSTRUCTURE AND PROCESSING
LA English
DT Article
DE Welding; Aluminum alloys; Fatigue; Fracture
ID TOOL ROTATIONAL SPEED; MECHANICAL-PROPERTIES; MAGNESIUM ALLOY; PIN
PROFILE; AL-ALLOYS; TENSILE-STRENGTH; 6061-T6 ALUMINUM; CAST A356-T6; MG
ALLOY; MICROSTRUCTURE
AB In this work, experiments were conducted to quantify structure-property relations of low-cycle fatigue behavior of dissimilar friction stir welding (FSW) of AA6061-to-AA7050 high strength aluminum alloys. In addition, a microstructure-sensitive fatigue model is employed to further elucidate cause-effect relationships. Experimental strain-controlled fatigue testing revealed an increase in the cyclic strain hardening and the number-of cycles to failure as the tool rotational speed was increased. At higher applied strain amplitudes (> 0.3%), the corresponding stress amplitude increased and the plastic strain amplitude decreased, as the number of cycles increased. However, at 0.2% strain amplitude, the plastic strain decreased until it was almost negligible. Inspection of the hysteresis loops demonstrated that at low strain amplitudes, there was an initial stage of strain hardening that increased until it reached a maximum strain hardening level, afterwards a nearly perfect elastic behavior was observed. Under fully-reversed fatigue loading, all samples failed at the region between the heat-affected and thermomechnically-affected zones. Inspection of the fractured surfaces under scanning electron microscopy revealed that the cracks initiated at either the crown or the root surface of the weld, and from secondary intermetallic particles located near the free surface of the weld. Lastly, a microstructure-sensitive multistage fatigue model was employed to correlate the fatigue life of the dissimilar FSW of AA6061-to-AA7050 considering microstructural features such as grain size, intermetallic particles and mechanical properties. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Rodriguez, R. I.; Jordon, J. B.; Allison, P. G.] Univ Alabama, Dept Mech Engn, Tuscaloosa, AL 35487 USA.
[Rushing, T.; Garcia, L.] Army Corps Engineers, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Jordon, JB (reprint author), Univ Alabama, Dept Mech Engn, Tuscaloosa, AL 35487 USA.
EM bjordon@eng.ua.edu
FU U.S. Army Research Office Scientific Services Program
[W911NF-11-D-0001]; University of Alabama; GAANN Fellowship Program
FX The authors would like to acknowledge Mr. Robert McCullough, Dr. Mark
Barkey, and Mr. Jeb Tingle for the their helpful discussions. In
addition, the authors would like to thank Mr. Cody Rickard for his help
in preparing the samples for mechanical testing and metallurgical
analysis. The authors would also like to thank The Edison Welding
Instituted (EWI) for FSW the joints. A portion of the work was performed
under the auspices of the U.S. Army Research Office Scientific Services
Program administered by Battelle Memorial Institute, Contract No.
W911NF-11-D-0001. Permission to publish was granted by Director,
Geotechnical and Structures Laboratory. Additionally, this work utilized
resources owned and maintained by the Central Analytical Facility, which
is supported by The University of Alabama. Lastly, the authors would
like to acknowledge the GAANN Fellowship Program for partial support of
this project.
NR 57
TC 2
Z9 2
U1 7
U2 24
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0921-5093
EI 1873-4936
J9 MAT SCI ENG A-STRUCT
JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process.
PD JAN 27
PY 2016
VL 654
BP 236
EP 248
DI 10.1016/j.msea.2015.11.075
PG 13
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary;
Metallurgy & Metallurgical Engineering
SC Science & Technology - Other Topics; Materials Science; Metallurgy &
Metallurgical Engineering
GA DD7NJ
UT WOS:000370111100027
ER
PT J
AU Liu, B
Xu, W
Yan, PF
Sun, XL
Bowden, ME
Read, J
Qian, JF
Mei, DH
Wang, CM
Zhang, JG
AF Liu, Bin
Xu, Wu
Yan, Pengfei
Sun, Xiuliang
Bowden, Mark E.
Read, Jeffrey
Qian, Jiangfeng
Mei, Donghai
Wang, Chong-Min
Zhang, Ji-Guang
TI Enhanced Cycling Stability of Rechargeable Li-O-2 Batteries Using
High-Concentration Electrolytes
SO ADVANCED FUNCTIONAL MATERIALS
LA English
DT Article
DE air electrodes; high-concentration electrolytes; Li-O-2 batteries;
lithium metal; stability
ID LITHIUM-OXYGEN BATTERIES; ETHER-BASED ELECTROLYTES; CARBONATE
ELECTROLYTES; BIFUNCTIONAL CATALYST; ION BATTERIES; AIR BATTERY;
REVERSIBILITY; LIMITATIONS; SOLVATION; DENSITY
AB The stability of electrolytes against highly reactive, reduced oxygen species is crucial for the development of rechargeable Li-O-2 batteries. In this work, the effect of lithium salt concentration in 1,2-dimethoxyethane (DME)-based electrolytes on the cycling stability of Li-O-2 batteries is investigated systematically. Cells with highly concentrated electrolyte demonstrate greatly enhanced cycling stability under both full discharge/charge (2.0-4.5 V vs Li/Li+) and the capacity-limited (at 1000 mAh g(-1)) conditions. These cells also exhibit much less reaction residue on the charged air-electrode surface and much less corrosion of the Li-metal anode. Density functional theory calculations are used to calculate molecular orbital energies of the electrolyte components and Gibbs activation energy barriers for the superoxide radical anion in the DME solvent and Li+-(DME) (n) solvates. In a highly concentrated electrolyte, all DME molecules are coordinated with salt cations, and the C-H bond scission of the DME molecule becomes more difficult. Therefore, the decomposition of the highly concentrated electrolyte can be mitigated, and both air cathodes and Li-metal anodes exhibit much better reversibility, resulting in improved cyclability of Li-O-2 batteries.
C1 [Liu, Bin; Xu, Wu; Qian, Jiangfeng; Zhang, Ji-Guang] Pacific NW Natl Lab, Energy & Environm Directorate, Richland, WA 99354 USA.
[Yan, Pengfei; Bowden, Mark E.; Wang, Chong-Min] Pacific NW Natl Lab, Environm Mol Sci Lab, Richland, WA 99354 USA.
[Sun, Xiuliang; Mei, Donghai] Pacific NW Natl Lab, Fundamental & Computat Sci Directorate, Richland, WA 99354 USA.
[Sun, Xiuliang] Beijing Univ Chem Technol, Dept Chem Engn, Beijing 100029, Peoples R China.
[Read, Jeffrey] US Army, Res Lab, Sensors & Elect Devices Directorate, Power & Energy Div, Adelphi, MD 20783 USA.
RP Xu, W; Zhang, JG (reprint author), Pacific NW Natl Lab, Energy & Environm Directorate, Richland, WA 99354 USA.
EM wu.xu@pnnl.gov; jiguang.zhang@pnnl.gov
RI yan, pengfei/E-4784-2016; Mei, Donghai/A-2115-2012; Mei,
Donghai/D-3251-2011; Liu, Bin/J-6942-2012
OI yan, pengfei/0000-0001-6387-7502; Mei, Donghai/0000-0002-0286-4182; Liu,
Bin/0000-0001-8797-3275
FU Office of Vehicle Technologies of the US Department of Energy (DOE)
[DEAC02-05CH11231, DEAC02-98CH10886]; DOE's Office of Biological and
Environmental Research (BER); DOE [DE-AC05-76RLO1830]
FX This work was supported by the Assistant Secretary for Energy Efficiency
and Renewable Energy, Office of Vehicle Technologies of the US
Department of Energy (DOE) under Contract no. DEAC02-05CH11231 for PNNL
and under DEAC02-98CH10886 under the Advanced Battery Materials Research
(BMR) program. The microscopic and spectroscopic characterizations were
conducted in the William R. Wiley Environmental Molecular Sciences
Laboratory (EMSL)-a national scientific user facility located at PNNL
which is sponsored by the DOE's Office of Biological and Environmental
Research (BER). PNNL is operated by Battelle for the DOE under Contract
DE-AC05-76RLO1830.
NR 40
TC 7
Z9 7
U1 22
U2 87
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 1616-301X
EI 1616-3028
J9 ADV FUNCT MATER
JI Adv. Funct. Mater.
PD JAN 26
PY 2016
VL 26
IS 4
BP 605
EP 613
DI 10.1002/adfm.201503697
PG 9
WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied;
Physics, Condensed Matter
SC Chemistry; Science & Technology - Other Topics; Materials Science;
Physics
GA DC0DA
UT WOS:000368886000015
ER
PT J
AU Hauser, JL
Tran, DT
Conley, ET
Saunders, JM
Bustillo, KC
Oliver, SRJ
AF Hauser, Jesse L.
Tran, Dat T.
Conley, Edward T.
Saunders, John M.
Bustillo, Karen C.
Oliver, Scott R. J.
TI Plasma Treatment of Silver Impregnated Mesoporous Aluminosilicate
Nanoparticles for Adsorptive Desulfurization
SO CHEMISTRY OF MATERIALS
LA English
DT Article
ID DEEP DESULFURIZATION; SELECTIVE ADSORPTION; JET FUEL; TRANSPORTATION
FUELS; PI-COMPLEXATION; ACTIVE-SITES; LIQUID FUELS; DIESEL FUEL;
ADSORBENTS; OXIDATION
AB We report a regenerable adsorbent for the removal of refractory organosulfur compounds from fossil fuels. The material is composed of well dispersed silver nanoparticles confined within the mesochannels of aluminum doped MCM-41 nanoparticles. With an average initial desulfurization capacity of 15 mg S.g(-1), 79% desulfurization capacity is retained after six cycles for the removal of dibenzothiophene from n-decane. The addition of intraframework aluminum to form a mesoporous aluminosilicate nanoparticle (MASN) aids in the retention and dispersion of silver ions within the mesochannels (Ag-MASN). The nanoparticles are subsequently reduced by glow discharge plasma treatment in argon (PT-Ag-MASN). The size dispersion, surface area, and structural integrity were characterized by scanning electron microscopy, annular dark-field scanning transmission electron microscopy (ADF-STEM), nitrogen adsorption analysis (BET), and powder X-ray diffraction. Silver nanoparticle formation within the mesochannels of MASN was confirmed by ADF-STEM and diffuse reflectance UV-vis spectroscopy. Model fuel testing revealed that PT Ag-MASN had the highest regeneration capacity after six cycles compared to non-plasma-treated (Ag-MASN) and aluminum-free materials (Ag-MSN and PT-Ag-MSN). Initial testing of the military jet fuel JP-8 also shows a high desulfurization capacity of 41 mg S.g(-1).
C1 [Hauser, Jesse L.; Conley, Edward T.; Saunders, John M.; Oliver, Scott R. J.] Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA.
[Tran, Dat T.] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
[Bustillo, Karen C.] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Natl Ctr Electron Microscopy, Mol Foundry, Berkeley, CA 94720 USA.
RP Oliver, SRJ (reprint author), Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA.; Tran, DT (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM dat.t.tran4.civ@mail.mil; soliver@ucsc.edu
FU Office of Science, Office of Basic Energy Sciences, of the U.S.
Department of Energy [DE-AC02-05CH11231]
FX We acknowledge the assistance of Rob Franks with inductively coupled
plasma-optical emission spectroscopy (ICP-OES) in the Institute of
Marine Sciences at UC Santa Cruz. We also acknowledge Dr. Tom Yuzvinsky
and the W.M. Keck Center for Nanoscale Optofluidics at UC Santa Cruz for
the use and assistance in image acquisition on the FEI Quanta 3D
Dualbeam microscope. We acknowledge the assistance of the National
Center for Electron Microscopy, Molecular Foundry, Lawrence Berkeley
National Lab, for use and image acquisition on the FEI Titan TEM. Work
at the Molecular Foundry was supported by the Office of Science, Office
of Basic Energy Sciences, of the U.S. Department of Energy under
Contract No. DE-AC02-05CH11231.
NR 26
TC 3
Z9 3
U1 15
U2 46
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0897-4756
EI 1520-5002
J9 CHEM MATER
JI Chem. Mat.
PD JAN 26
PY 2016
VL 28
IS 2
BP 474
EP 479
DI 10.1021/acs.chemmater.5b03018
PG 6
WC Chemistry, Physical; Materials Science, Multidisciplinary
SC Chemistry; Materials Science
GA DC1AT
UT WOS:000368949900011
ER
PT J
AU Duarte, A
Hatfield, JS
Swannack, TM
Forstner, MRJ
Green, MC
Weckerly, FW
AF Duarte, Adam
Hatfield, Jeff S.
Swannack, Todd M.
Forstner, Michael R. J.
Green, M. Clay
Weckerly, Floyd W.
TI Simulating range-wide population and breeding habitat dynamics for an
endangered woodland warbler in the face of uncertainty
SO ECOLOGICAL MODELLING
LA English
DT Article
DE Extinction risk; Habitat conservation; Habitat dynamics; Multistate
model; Population dynamics; Setophaga chrysoparia
ID GOLDEN-CHEEKED WARBLER; LAND-COVER DATABASE; ASHE JUNIPER;
TRANSITION-PROBABILITIES; CONSERVATION; COMMUNITIES; LANDSCAPES;
SUCCESSION; THRESHOLD; RECOVERY
AB Population viability analyses provide a quantitative approach that seeks to predict the possible future status of a species of interest under different scenarios and, therefore, can be important components of large-scale species' conservation programs. We created a model and simulated range-wide population and breeding habitat dynamics for an endangered woodland warbler, the golden-cheeked warbler (Setophaga chrysoparia). Habitat-transition probabilities were estimated across the warbler's breeding range by combining National Land Cover Database imagery with multistate modeling. Using these estimates, along with recently published demographic estimates, we examined if the species can remain viable into the future given the current conditions. Lastly, we evaluated if protecting a greater amount of habitat would increase the number of warblers that can be supported in the future by systematically increasing the amount of protected habitat and comparing the estimated terminal carrying capacity at the end of 50 years of simulated habitat change. The estimated habitat-transition probabilities supported the hypothesis that habitat transitions are unidirectional, whereby habitat is more likely to diminish than regenerate. The model results indicated population viability could be achieved under current conditions, depending on dispersal. However, there is considerable uncertainty associated with the population projections due to parametric uncertainty. Model results suggested that increasing the amount of protected lands would have a substantial impact on terminal carrying capacities at the end of a 50-year simulation. Notably, this study identifies the need for collecting the data required to estimate demographic parameters in relation to changes in habitat metrics and population density in multiple regions, and highlights the importance of establishing a common definition of what constitutes protected habitat, what management goals are suitable within those protected areas, and a standard operating procedure to identify areas of priority for habitat conservation efforts. Therefore, we suggest future efforts focus on these aspects of golden-cheeked warbler conservation and ecology. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Duarte, Adam; Swannack, Todd M.; Forstner, Michael R. J.; Green, M. Clay; Weckerly, Floyd W.] Texas State Univ, Dept Biol, San Marcos, TX USA.
[Hatfield, Jeff S.] US Geol Survey, Patuxent Wildlife Res Ctr, Laurel, MD USA.
[Swannack, Todd M.] US Army Engineer Res & Dev Ctr, Vicksburg, MS USA.
RP Duarte, A (reprint author), Oregon State Univ, Dept Fisheries & Wildlife, Oregon Cooperat Fish & Wildlife Res Unit, Corvallis, OR 97331 USA.
EM adam.duarte@oregonstate.edu
FU U.S. Geological Survey Science Support Partnership Program through U.S.
Fish and Wildlife Service, Texas State University; Houston Safari Club;
National Wild Turkey Federation
FX We thank J. D. Nichols, J. R. Sauer, and an anonymous reviewer for
reviewing an earlier draft of the manuscript. J. L. R. Jensen allowed us
to use her computers to run a portion of the simulations, and we are
grateful. This project was funded by the U.S. Geological Survey Science
Support Partnership Program through the U.S. Fish and Wildlife Service,
Texas State University, the Houston Safari Club, and the National Wild
Turkey Federation. Recovery-unit boundary shapefiles were provided by
the Austin Ecological Services Office of the USFWS. Conservation and
recreation-land shapefiles were provided by Texas Parks & Wildlife
Department Land and Water Resources Conservation and Recreation Plan
Statewide Inventory-2012 and military-land shapefiles were downloaded
from the Defense Installation Spatial Data Infrastructure website
(http://www.acq.osd.mil/ie/). Any use of trade, product, or firm names
is for descriptive purposes only and does not imply endorsement by the
U.S. Government.
NR 43
TC 0
Z9 0
U1 4
U2 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0304-3800
EI 1872-7026
J9 ECOL MODEL
JI Ecol. Model.
PD JAN 24
PY 2016
VL 320
BP 52
EP 61
DI 10.1016/j.ecolmodel.2015.09.018
PG 10
WC Ecology
SC Environmental Sciences & Ecology
GA DB2BM
UT WOS:000368313300005
ER
PT J
AU Matheny, RW
Geddis, AV
Abdalla, MN
Leandry, LA
AF Matheny, Ronald W., Jr.
Geddis, Alyssa V.
Abdalla, Mary N.
Leandry, Luis A.
TI Phosphatidylinositol 3-kinase p110 alpha mediates phosphorylation of
AMP-activated protein kinase in myoblasts
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Phosphatidylinositol 3-kinase (PI3K); AMP-Activated protein kinase
(AMPK); p110 alpha; Akt; Myoblast
ID SKELETAL-MUSCLE; EXERCISE INTENSITY; AKT ACTIVATION; INSULIN; P110-BETA;
CELLS; SER(485/491); DOWNSTREAM; AGENTS; HEART
AB AMP-activated protein kinase (AMPK) is a serine/threonine kinase that functions as a sensor of intracellular energy. Activation of AMPK is associated with increased phosphorylation of the a-subunit at threonine 172 (T172) and decreased phosphorylation at serine 485 in AMPK alpha 1 and serine 491 in AMPK alpha 2 (S485/491). One potential mediator of AMPK phosphorylation is phosphatidylinositol 3-kinase (PI3K); however, the mechanism and the identities of the specific PI3K isoforms that regulate AMPK activation are not known. To determine whether PI3K p110 alpha regulated AMPK activation in muscle cells, C2C12 myoblasts were subjected to pharmacological inhibition of p110 alpha, siRNA directed against p110 alpha, or overexpression of constitutively-active or dominant negative p110 alpha. Chemical inhibition, siRNA, and expression of dominant-negative p110 alpha were all associated with increased AMPK T172 phosphorylation, whereas expression of constitutively-active p110 alpha reduced T172 phosphorylation. Conversely, pharmacological inhibition of p110 alpha reduced AMPK S485/491 phosphorylation, while constitutively-active p110 alpha increased AMPK S485/491 phosphorylation. This p110 alpha-mediated increase in AMPK S485/491 phosphorylation was eliminated in the presence of the Akt inhibitor MK2206, suggesting that p110 alpha-mediated phosphorylation of AMPK alpha at S485/491 is Akt-dependent. In response to oligomycin or serum starvation, AMPK T172 phosphorylation was elevated in p11 alpha-deficient myoblasts compared to control myoblasts. Overall, our findings identify PI3K p110a as a mediator of AMPK phosphorylation in myoblasts. (C) Published by Elsevier Inc.
C1 [Matheny, Ronald W., Jr.; Geddis, Alyssa V.; Abdalla, Mary N.; Leandry, Luis A.] US Army Res Inst Environm Med, Mil Performance Div, 15 Kansas St,Bldg 42, Natick, MA 01760 USA.
[Abdalla, Mary N.] Univ Massachusetts, Sch Med, Dept Mol Cell & Canc Biol, 364 Plantat St, Worcester, MA 01605 USA.
RP Matheny, RW (reprint author), US Army Res Inst Environm Med, Mil Performance Div, 15 Kansas St,Bldg 42, Natick, MA 01760 USA.
EM ronald.w.matheny.civ@mail.mil
FU U.S. Department of Energy; U.S. Army Medical Research and Materiel
Command
FX A.V.G. and M.N.A. were supported by appointments to the Postgraduate
Research Participation Program at the U.S. Army Research Institute of
Environmental Medicine administered by the Oak Ridge Institute for
Science and Education through interagency agreement between the U.S.
Department of Energy and U.S. Army Medical Research and Materiel
Command.
NR 31
TC 2
Z9 2
U1 1
U2 1
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD JAN 22
PY 2016
VL 469
IS 4
BP 1117
EP 1122
DI 10.1016/j.bbrc.2015.12.118
PG 6
WC Biochemistry & Molecular Biology; Biophysics
SC Biochemistry & Molecular Biology; Biophysics
GA DC6TR
UT WOS:000369353000050
PM 26742424
ER
PT J
AU Wright, LKM
Lee, RB
Vincelli, NM
Whalley, CE
Lumley, LA
AF Wright, Linnzi K. M.
Lee, Robyn B.
Vincelli, Nicole M.
Whalley, Christopher E.
Lumley, Lucille A.
TI Comparison of the lethal effects of chemical warfare nerve agents across
multiple ages
SO TOXICOLOGY LETTERS
LA English
DT Article
DE Chemical warfare nerve agent; Development; Median lethal dose; Rat;
Subcutaneous
ID ORGANOPHOSPHORUS COMPOUNDS; SOMAN TOXICITY; EXPOSURE CONCENTRATION;
ESTERASE-ACTIVITIES; GUINEA-PIGS; RATS; CARBOXYLESTERASE; PROTECTION;
BRAIN; VAPOR
AB Children may be inherently more vulnerable than adults to the lethal effects associated with chemical warfare nerve agent (CWNA) exposure because of their closer proximity to the ground, smaller body mass, higher respiratory rate, increased skin permeability and immature metabolic systems. Unfortunately, there have only been a handful of studies on the effects of CWNA in pediatric animal models, and more research is needed to confirm this hypothesis. Using a stagewise, adaptive dose design, we estimated the 24 h median lethal dose for subcutaneous exposure to seven CWNA in both male and female Sprague-Dawley rats at six different developmental times. Perinatal (postnatal day [PND] 7, 14 and 21) and adult (PND 70) rats were more susceptible than pubertal (PND 28 and 42) rats to the lethal effects associated with exposure to tabun, sarin, soman and cyclosarin. Age-related differences in susceptibility were not observed in rats exposed to VM, Russian VX or VX. Published by Elsevier Ireland Ltd.
C1 [Wright, Linnzi K. M.; Lee, Robyn B.; Lumley, Lucille A.] US Army Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA.
[Vincelli, Nicole M.; Whalley, Christopher E.] Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA.
RP Lumley, LA (reprint author), US Army Med Res Inst Chem Def, 2900 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA.
EM lucille.a.lange.civ@mail.mil
NR 36
TC 2
Z9 3
U1 1
U2 130
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0378-4274
EI 1879-3169
J9 TOXICOL LETT
JI Toxicol. Lett.
PD JAN 22
PY 2016
VL 241
BP 167
EP 174
DI 10.1016/j.toxlet.2015.11.023
PG 8
WC Toxicology
SC Toxicology
GA DA2VA
UT WOS:000367653700018
PM 26621540
ER
PT J
AU Sellers, MS
Hurley, MM
AF Sellers, Michael S.
Hurley, Margaret M.
TI XPairIt Docking Protocol for peptide docking and analysis
SO MOLECULAR SIMULATION
LA English
DT Article
DE peptide docking; software design; docking methodology
ID MOLECULAR-DYNAMICS; DRUG DESIGN; RECEPTOR FLEXIBILITY; PROTEINS;
BINDING; COMPLEXES; ALGORITHM; KNOWLEDGE; ROSETTA; NAMD
AB The mechanics of peptide-protein docking has long been an area of intense interest to the computational community. Here we discuss an improved docking protocol named XPairIt which uses a multitier approach, combining the PyRosetta docking software with the NAMD molecular dynamics package through a biomolecular simulation programming interface written in Python. This protocol is designed for systems where no a priori information of ligand structure (beyond sequence) or binding location is known. It provides for efficient incorporation of both ligand and target flexibility, is HPC-ready and is easily extensible for use of custom code. We apply this protocol to a set of 11 test cases drawn from benchmarking databases and from previously published studies for direct comparison with existing protocols. Strengths, weaknesses and areas of improvement are discussed.
C1 [Sellers, Michael S.; Hurley, Margaret M.] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
RP Sellers, MS (reprint author), US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
EM michael.s.sellers.ctr@us.army.mil
FU Defense Threat Reduction Agency Joint Science and Technology Office for
Chemical and Biological Defense [BRCALL08-Per3-P-2-0028]; U.S. Army
Research Laboratory
FX This project received support from the Defense Threat Reduction Agency
Joint Science and Technology Office for Chemical and Biological Defense
[grant number BRCALL08-Per3-P-2-0028]. Research is also supported in
part by appointments to the U.S. Army Research Laboratory Postdoctoral
Fellowship Program administered by the Oak Ridge Associated Universities
through a contract with the U.S. Army Research Laboratory.
NR 42
TC 2
Z9 2
U1 2
U2 25
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0892-7022
EI 1029-0435
J9 MOL SIMULAT
JI Mol. Simul.
PD JAN 22
PY 2016
VL 42
IS 2
BP 149
EP 161
DI 10.1080/08927022.2015.1025267
PG 13
WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical
SC Chemistry; Physics
GA CS6LL
UT WOS:000362190200007
ER
PT J
AU Przekwas, A
Somayaji, MR
Gupta, RK
AF Przekwas, Andrzej
Somayaji, Mahadevabharath R.
Gupta, Raj K.
TI Synaptic Mechanisms of Blast-Induced Brain Injury
SO FRONTIERS IN NEUROLOGY
LA English
DT Article
DE synapse; TBI; neuro-axonal; blast wave injury; mechanobiology; DAI
ID CELL-ADHESION MOLECULES; IN-VITRO; SUBDURAL-HEMATOMA; AXONAL INJURY;
DEFORMATION; STRESS; PLASTICITY; SYNAPSES; BIOMECHANICS; DISORDERS
AB Blast wave-induced traumatic brain injury (TBI) is one of the most common injuries to military personnel. Brain tissue compression/tension due to blast-induced cranial deformations and shear waves due to head rotation may generate diffuse micro-damage to neuro-axonal structures and trigger a cascade of neurobiological events culminating in cognitive and neurodegenerative disorders. Although diffuse axonal injury is regarded as a signature wound of mild TBI (mTBI), blast loads may also cause synaptic injury wherein neuronal synapses are stretched and sheared. This synaptic injury may result in temporary disconnect of the neural circuitry and transient loss in neuronal communication. We hypothesize that mTBI symptoms such as loss of consciousness or dizziness, which start immediately after the insult, could be attributed to synaptic injury. Although empirical evidence is beginning to emerge; the detailed mechanisms underlying synaptic injury are still elusive. Coordinated in vitro-in vivo experiments and mathematical modeling studies can shed light into the synaptic injury mechanisms and their role in the potentiation of mTBI symptoms.
C1 [Przekwas, Andrzej; Somayaji, Mahadevabharath R.] CFD Res Corp, Computat Med & Biol Div, Huntsville, AL USA.
[Gupta, Raj K.] US Army Med Res & Mat Command, Dept Def Blast Injury Res Program Coordinating Of, Ft Detrick, MD USA.
RP Przekwas, A (reprint author), CFD Res Corp, Computat Med & Biol Div, Huntsville, AL USA.
EM andrzej.przekwas@cfdrc.com
FU Department of Defense Congressionally Directed Medical Research Programs
(CDMRP) [W81XWH-11-2-0057]
FX The authors (AJP and MRS) would like to express their appreciation to
the Department of Defense Congressionally Directed Medical Research
Programs (CDMRP) under contract W81XWH-11-2-0057 for supporting this
work. The authors acknowledge Dr. Vincent Harrand, CFDRC and Prof.
Beverly Rzigalinski, Virginia Tech, for reviewing the manuscript.
NR 90
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Z9 2
U1 5
U2 14
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015,
SWITZERLAND
SN 1664-2295
J9 FRONT NEUROL
JI Front. Neurol.
PD JAN 21
PY 2016
VL 7
AR UNSP 2
DI 10.3389/fneur.2016.00002
PG 8
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA DE2BD
UT WOS:000370430300001
PM 26834697
ER
PT J
AU Long, JW
Wallace, JM
Peterson, GW
Huynh, K
AF Long, Jeffrey W.
Wallace, Jean M.
Peterson, Gregory W.
Huynh, Kim
TI Manganese Oxide Nanoarchitectures as Broad-Spectrum Sorbents for Toxic
Gases
SO ACS APPLIED MATERIALS & INTERFACES
LA English
DT Article
DE manganese oxide; ammonia; sulfur dioxide; hydrogen sulfide; air
filtration
ID SELECTIVE CATALYTIC-REDUCTION; NANOCRYSTALLINE METAL-OXIDES;
SULFUR-DIOXIDE; REACTIVE ADSORPTION; SURFACE-CHEMISTRY;
AQUEOUS-SOLUTIONS; HYDROGEN-SULFIDE; ETHYL SULFIDE; FT-IR; OXIDATION
AB We demonstrate that sol-gel-derived manganese oxide (MnOx) nanoarchitectures exhibit broad-spectrum filtration activity for three chemically diverse toxic gases: NH3, SO2, and H2S. Manganese oxides are synthesized via the reaction of NaMnO4 and fumaric acid to form monolithic gels of disordered, mixed-talent Na-MnOx; incorporated Na+ is readily exchanged for H+ by subsequent acid rinsing to form a more crystalline H-MnOx phase. For both Na-MnOx and H-MnOx forms, controlled pore-fluid removal yields either densified, yet still mesoporous, xerogels or low-density aerogels (prepared by drying from supercritical CO2). The performance of these MnOx nanoarchitectures as filtration media is assessed using dynamic-challenge microbreakthrough protocols. We observe technologically relevant sorption capacities under both dry conditions and wet (80% relative humidity) for each of the three toxic industrial chemicals investigated. The Na-MnOx xerogels and aerogels provide optimal performance with the aerogel exhibiting maximum sorption capacities of 39, 200, and 680 mg g(-1) for NH3, SO2, and H2S, respectively. Postbreakthrough characterization using X-ray photoelectron spectroscopy (XPS) and diffuse-reflectance infrared Fourier transform spectroscopy (DRIFTS) confirms that NH3 is captured and partially protonated within the MnOx structure, while SO2 undergoes oxidation by the redox-active oxide to form adsorbed sulfate at the MnOx surface. Hydrogen sulfide is also oxidized to form a combination of sulfate and sulfur/polysulfide products, concomitant with a decrease in the average Mn oxidation state from 3.43 to 2.94 and generation of a MnOOH phase.
C1 [Long, Jeffrey W.] US Naval Res Lab, Surface Chem Branch, Code 6170, Washington, DC 20375 USA.
[Wallace, Jean M.] Nova Res Inc, Alexandria, VA 22308 USA.
[Peterson, Gregory W.] US Army, Res Dev & Engn Command, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA.
[Huynh, Kim] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA.
RP Long, JW (reprint author), US Naval Res Lab, Surface Chem Branch, Code 6170, Washington, DC 20375 USA.
EM jeffrey.long@nrl.navy.mil
FU U.S. Office of Naval Research; Edgewood Chemical Biological Center
(Aberdeen, MD); U.S. Defense Threat Reduction Agency
FX J.W.L. acknowledges the support of the U.S. Office of Naval Research and
Edgewood Chemical Biological Center (Aberdeen, MD). G.W.P. and K.L.T.H.
acknowledge the support of the U.S. Defense Threat Reduction Agency.
NR 66
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U1 14
U2 58
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1944-8244
J9 ACS APPL MATER INTER
JI ACS Appl. Mater. Interfaces
PD JAN 20
PY 2016
VL 8
IS 2
BP 1184
EP 1193
DI 10.1021/acsami.5b09508
PG 10
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary
SC Science & Technology - Other Topics; Materials Science
GA DB6UL
UT WOS:000368651100016
PM 26741498
ER
PT J
AU Pittman, PR
McClain, D
Quinn, X
Coonan, KM
Mangiafico, J
Makuch, RS
Morrill, J
Peters, CJ
AF Pittman, Phillip R.
McClain, David
Quinn, Xiaofei
Coonan, Kevin M.
Mangiafico, Joseph
Makuch, Richard S.
Morrill, John
Peters, Clarence J.
TI Safety and immunogenicity of a mutagenized, live attenuated Rift Valley
fever vaccine, MP-12, in a Phase 1 dose escalation and route comparison
study in humans
SO VACCINE
LA English
DT Article
DE MP-12; Rift Valley fever; Vaccine; Clinical trial
ID VIRUS-VACCINE; AEROSOL CHALLENGE; RHESUS-MONKEYS; PREGNANT SHEEP;
SAUDI-ARABIA; NSM GENES; PATHOGENICITY; PROTECTION; INFECTION; EFFICACY
AB Rift Valley fever (RVF) poses a risk as a potential agent in bioterrorism or agroterrorism. A live attenuated RVF vaccine (RVF MP-12) has been shown to be safe and protective in animals and showed promise in two initial clinical trials. In the present study, healthy adult human volunteers (N=56) received a single injection of (a) RVF MP-12, administered subcutaneously (SQ) at a concentration of 10(4.7) plaque-forming units (pfu) (SQ Group); (b) RVF MP-12, administered intramuscularly (IM) at 10(3.4) pfu (IM Group 1); (c) RVF MP-12, administered IM at 10(4.4) pfu (IM Group 2); or (d) saline (Placebo Group). The vaccine was well tolerated by volunteers in all dose and route groups. Infrequent and minor adverse events were seen among recipients of both placebo and RVF MP-12. One subject had viremia detectable by direct plaque assay, and six subjects from IM Group 2 had transient low-titer viremia detectable only by nucleic acid amplification. Of the 43 vaccine recipients, 40 (93%) achieved neutralizing antibodies (measured as an 80% plaque reduction neutralization titer [PRNT80]) as well as RVF-specific IgM and IgG. The highest peak geometric mean PRNT80 titers were observed in IM Group 2. Of 34 RVF MP-12 recipients available for testing 1 year following inoculation, 28 (82%) remained seropositive (PRNT80 >= 1:20); this included 20 of 23 vaccinees (87%) from IM Group 2. The live attenuated RVF MP-12 vaccine was safe and immunogenic at the doses and routes studied. Given the need for an effective vaccine against RVF virus, further evaluation in humans is warranted. Published by Elsevier Ltd.
C1 [Pittman, Phillip R.; McClain, David; Quinn, Xiaofei; Coonan, Kevin M.; Mangiafico, Joseph; Makuch, Richard S.; Morrill, John; Peters, Clarence J.] US Army, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA.
RP Pittman, PR (reprint author), US Army, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA.
EM phillip.r.pittman.civ@mail.mil
FU U.S. Army Medical Materiel Development Activity, Medical Research and
Materiel Command, U.S. Department of Defense
FX We are most grateful to Elizabeth Brown, Ph.D., for her scholarly review
and editing of this manuscript. We thank the skillful assistance of
Denise Danner and Julie Hile in the completion of serology and viremia
assays. The research described herein was sponsored by the U.S. Army
Medical Materiel Development Activity, Medical Research and Materiel
Command, U.S. Department of Defense.
NR 42
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U1 0
U2 4
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
EI 1873-2518
J9 VACCINE
JI Vaccine
PD JAN 20
PY 2016
VL 34
IS 4
BP 424
EP 429
DI 10.1016/j.vaccine.2015.12.030
PG 6
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA DB9WJ
UT WOS:000368868100006
PM 26718688
ER
PT J
AU Nallon, EC
Schnee, VP
Bright, CJ
Polcha, MP
Li, QL
AF Nallon, Eric C.
Schnee, Vincent P.
Bright, Collin J.
Polcha, Michael P.
Li, Qiliang
TI Discrimination Enhancement with Transient Feature Analysis of a Graphene
Chemical Sensor
SO ANALYTICAL CHEMISTRY
LA English
DT Article
ID GAS SENSORS; ARRAYS; LAYER
AB A graphene chemical sensor is subjected to a set of structurally and chemically similar hydrocarbon compounds consisting of toluene, o-xylene, p-xylene, and mesitylene. The fractional change in resistance of the sensor upon exposure to these compounds exhibits a similar response magnitude among compounds, whereas large variation is observed within repetitions for each compound, causing a response overlap. Therefore, traditional features depending on maximum response change will cause confusion during further discrimination and classification analysis. More robust features that are less sensitive to concentration, sampling, and drift variability would provide higher quality information. In this work, we have explored the advantage of using transient-based exponential fitting coefficients to enhance the discrimination of similar compounds. The advantages of such feature analysis to discriminate each compound is evaluated using principle component analysis (PCA). In addition, machine learning-based classification algorithms were used to compare the prediction accuracies when using fitting coefficients as features. The additional features greatly enhanced the discrimination between compounds while performing PCA and also improved the prediction accuracy by 34% when using linear discrimination analysis.
C1 [Nallon, Eric C.; Schnee, Vincent P.] US Army, RDECOM CERDEC Night Vis & Elect Sensors Directora, Ft Belvoir, VA 22060 USA.
[Nallon, Eric C.; Li, Qiliang] George Mason Univ, Dept Elect & Comp Engn, Fairfax, VA 22030 USA.
[Polcha, Michael P.] Fulcrum IT Serv, Centerville, VA 20120 USA.
[Bright, Collin J.] CACI Int Inc, Arlington, VA 22201 USA.
RP Nallon, EC (reprint author), 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA.
EM eric.c.nallon.civ@mail.mil
NR 32
TC 1
Z9 1
U1 9
U2 17
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0003-2700
EI 1520-6882
J9 ANAL CHEM
JI Anal. Chem.
PD JAN 19
PY 2016
VL 88
IS 2
BP 1401
EP 1406
DI 10.1021/acs.analchem.5b04050
PG 6
WC Chemistry, Analytical
SC Chemistry
GA DB5OA
UT WOS:000368562300048
PM 26674670
ER
PT J
AU Beal, SA
Osterberg, EC
Zdanowicz, CM
Fisher, DA
AF Beal, Samuel A.
Osterberg, Erich C.
Zdanowicz, Christian M.
Fisher, David A.
TI Response to Comment on "Ice Core Perspective on Mercury Pollution during
the Past 600 Years"
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Letter
ID ARCHIVES
C1 [Beal, Samuel A.] US Army, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA.
[Osterberg, Erich C.] Dartmouth Coll, Dept Earth Sci, Hanover, NH 03755 USA.
[Zdanowicz, Christian M.] Uppsala Univ, Dept Earth Sci, S-75105 Uppsala, Sweden.
[Fisher, David A.] Univ Ottawa, Dept Earth Sci, Ottawa, ON K1N 6N5, Canada.
RP Beal, SA (reprint author), US Army, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA.
EM samuel.beal@usace.army.mil
OI Zdanowicz, Christian/0000-0002-1045-5063
NR 6
TC 0
Z9 0
U1 2
U2 5
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD JAN 19
PY 2016
VL 50
IS 2
BP 1068
EP 1069
DI 10.1021/acs.est.5b05444
PG 2
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA DB5OL
UT WOS:000368563400062
PM 26709862
ER
PT J
AU Schultz, BT
Teigler, JE
Pissani, F
Oster, AF
Kranias, G
Alter, G
Marovich, M
Eller, MA
Dittmer, U
Robb, ML
Kim, JH
Michael, NL
Bolton, D
Streeck, H
AF Schultz, Bruce T.
Teigler, Jeffrey E.
Pissani, Franco
Oster, Alexander F.
Kranias, Gregory
Alter, Galit
Marovich, Mary
Eller, Michael A.
Dittmer, Ulf
Robb, Merlin L.
Kim, Jerome H.
Michael, Nelson L.
Bolton, Diane
Streeck, Hendrik
TI Circulating HIV-Specific Interleukin-21(+)CD4(+) T Cells Represent
Peripheral Tfh Cells with Antigen-Dependent Helper Functions
SO IMMUNITY
LA English
DT Article
ID CHRONIC VIRAL-INFECTION; ANTIBODY-RESPONSES; VACCINE DEVELOPMENT;
EFFICACY TRIAL; DIFFERENTIATION; IL-21; PROLIFERATION; INDUCTION;
CYTOKINE; PROTEINS
AB A central effort in HIV vaccine development is to generate protective broadly neutralizing antibodies, a process dependent on T follicular helper (Tfh) cells. The feasibility of using peripheral blood counterparts of lymph node Tfh cells to assess the immune response and the influence of viral and vaccine antigens on their helper functions remain obscure. We assessed circulating HIV-specific IL-21(+) CD4(+) T cells and showed transcriptional and phenotypic similarities to lymphoid Tfh cells, and hence representing peripheral Tfh (pTfh) cells. pTfh cells were functionally active and B cell helper quality differed depending on antigen specificity. Furthermore, we found higher frequency of pTfh cells in peripheral blood mononuclear cell specimens from the ALVAC+AIDSVAX (RV144) HIV vaccine trial associated with protective antibody responses compared to the non-protective DNA+Ad5 vaccine trial. Together, we identify IL-21(+) CD4(+) T cells as pTfh cells, implicating them as key populations in the generation of vaccine-evoked antibody responses.
C1 [Schultz, Bruce T.; Teigler, Jeffrey E.; Pissani, Franco; Oster, Alexander F.; Kranias, Gregory; Marovich, Mary; Eller, Michael A.; Robb, Merlin L.; Kim, Jerome H.; Michael, Nelson L.; Bolton, Diane; Streeck, Hendrik] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA.
[Schultz, Bruce T.; Teigler, Jeffrey E.; Pissani, Franco; Oster, Alexander F.; Kranias, Gregory; Marovich, Mary; Eller, Michael A.; Robb, Merlin L.; Bolton, Diane; Streeck, Hendrik] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD 20817 USA.
[Schultz, Bruce T.; Streeck, Hendrik] Univ Duisburg Essen, Univ Hosp Essen, Inst HIV Res, D-45147 Essen, Germany.
[Alter, Galit] Ragon Inst MGH MIT & Harvard, Cambridge, MA 02139 USA.
[Dittmer, Ulf] Univ Duisburg Essen, Univ Hosp Essen, Inst Virol, D-45147 Essen, Germany.
[Kim, Jerome H.] Int Vaccine Inst, Seoul 151742, South Korea.
RP Streeck, H (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA.
EM hendrik.streeck@uk-essen.de
FU U.S. NIH [R01 AI091450-01, R01 AI094602-01]; Henry M. Jackson Foundation
for the Advancement of Military Medicine, Inc. [W81XWH-11-2-0174]; U.S.
Department of Defense (DOD) [W81XWH-11-2-0174]
FX We would like to thank Dr. Madelene Lindqvist and Dr. Jan van Lunzen for
their help with the manuscript. This work was funded by the U.S. NIH
(R01 AI091450-01 and R01 AI094602-01) and a cooperative agreement
(W81XWH-11-2-0174) between the Henry M. Jackson Foundation for the
Advancement of Military Medicine, Inc., and the U.S. Department of
Defense (DOD). The reagents HIV-1 PTE Gag and Env Peptides were obtained
through the NIH AIDS Reagent Program, Division of AIDS, NIAID, NIH;
human rIL-2 was from Dr. Maurice Gately, Hoffmann at La Roche Inc. The
views expressed are those of the authors and should not be construed to
represent the positions of the U.S. Army or the Department of Defense.
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PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 1074-7613
EI 1097-4180
J9 IMMUNITY
JI Immunity
PD JAN 19
PY 2016
VL 44
IS 1
BP 167
EP 178
DI 10.1016/j.immuni.2015.12.011
PG 12
WC Immunology
SC Immunology
GA DB2NU
UT WOS:000368347000021
PM 26795249
ER
PT J
AU Martin, MJ
Eckert, MJ
Schreiber, MA
AF Martin, Matthew J.
Eckert, Matthew J.
Schreiber, Martin A.
TI Relationship of a Mandated 1-Hour Evacuation Policy and Outcomes for
Combat Casualties
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Editorial Material
ID IN-HOSPITAL DEATHS; TRAUMA CARE
C1 [Martin, Matthew J.; Eckert, Matthew J.] Madigan Army Med Ctr, Dept Surg, Tacoma, WA 98431 USA.
[Schreiber, Martin A.] Oregon Hlth & Sci Univ, Dept Surg, Portland, OR 97201 USA.
RP Martin, MJ (reprint author), US Army, Med Corps, Madigan Army Med Ctr, Dept Surg, 9040-A Fitzsimmons Ave, Tacoma, WA 98431 USA.
EM matthew.j.martin16.mil@mail.mil
NR 9
TC 0
Z9 0
U1 0
U2 2
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0098-7484
EI 1538-3598
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD JAN 19
PY 2016
VL 315
IS 3
BP 293
EP 294
DI 10.1001/jama.2015.18744
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA DB2WN
UT WOS:000368371400026
PM 26784777
ER
PT J
AU Ganin, AA
Massaro, E
Gutfraind, A
Steen, N
Keisler, JM
Kott, A
Mangoubi, R
Linkov, I
AF Ganin, Alexander A.
Massaro, Emanuele
Gutfraind, Alexander
Steen, Nicolas
Keisler, Jeffrey M.
Kott, Alexander
Mangoubi, Rami
Linkov, Igor
TI Operational resilience: concepts, design and analysis
SO SCIENTIFIC REPORTS
LA English
DT Article
ID INFRASTRUCTURE SYSTEMS; DYNAMICAL NETWORKS; COMPLEX NETWORKS; FRAMEWORK;
FRAGILITY; FAILURES
AB Building resilience into today's complex infrastructures is critical to the daily functioning of society and its ability to withstand and recover from natural disasters, epidemics, and cyber-threats. This study proposes quantitative measures that capture and implement the definition of engineering resilience advanced by the National Academy of Sciences. The approach is applicable across physical, information, and social domains. It evaluates the critical functionality, defined as a performance function of time set by the stakeholders. Critical functionality is a source of valuable information, such as the integrated system resilience over a time interval, and its robustness. The paper demonstrates the formulation on two classes of models: 1) multi-level directed acyclic graphs, and 2) interdependent coupled networks. For both models synthetic case studies are used to explore trends. For the first class, the approach is also applied to the Linux operating system. Results indicate that desired resilience and robustness levels are achievable by trading off different design parameters, such as redundancy, node recovery time, and backup supply available. The nonlinear relationship between network parameters and resilience levels confirms the utility of the proposed approach, which is of benefit to analysts and designers of complex systems and networks.
C1 [Ganin, Alexander A.; Massaro, Emanuele; Steen, Nicolas; Linkov, Igor] US Army, Corps Engineers, Engineer Res & Dev Ctr, Environm Lab, Concord, MA 01742 USA.
[Ganin, Alexander A.] Univ Virginia, Dept Syst & Informat Engn, Charlottesville, VA 22904 USA.
[Massaro, Emanuele] Carnegie Mellon Univ, Dept Civil & Environm Engn, Pittsburgh, PA 15213 USA.
[Gutfraind, Alexander] Univ Illinois, Sch Publ Hlth, Chicago, IL 60612 USA.
[Keisler, Jeffrey M.] Univ Massachusetts, Coll Management, Boston, MA 02125 USA.
[Kott, Alexander] US Army, Res Lab, Network Sci Div, Adelphi, MD 20783 USA.
[Mangoubi, Rami] Charles Stark Draper Lab, Cambridge, MA 02139 USA.
RP Linkov, I (reprint author), US Army, Corps Engineers, Engineer Res & Dev Ctr, Environm Lab, Concord, MA 01742 USA.
EM Igor.Linkov@usace.army.mil
OI Ganin, Alexander/0000-0003-2193-0373
NR 50
TC 6
Z9 6
U1 10
U2 35
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JAN 19
PY 2016
VL 6
AR 19540
DI 10.1038/srep19540
PG 12
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DB1RL
UT WOS:000368286400001
PM 26782180
ER
PT J
AU Lee, YS
Lewis, JA
Ippolito, DL
Hussainzada, N
Lein, PJ
Jackson, DA
Stallings, JD
AF Lee, Young S.
Lewis, John A.
Ippolito, Danielle L.
Hussainzada, Naissan
Lein, Pamela J.
Jackson, David A.
Stallings, Jonathan D.
TI Repeated exposure to neurotoxic levels of chlorpyrifos alters
hippocampal expression of neurotrophins and neuropeptides
SO TOXICOLOGY
LA English
DT Article
DE Chlorpyrifos; Cholinesterase inhibition; Gene expression; Microarray;
miRNA Organophosphorus pesticide
ID LONG-TERM EXPOSURE; NEUROBEHAVIORAL PERFORMANCE; ORGANOPHOSPHATE
PESTICIDES; UP-REGULATION; RNA-SEQ; WORKERS; MEMORY; NEURONS; RATS;
CARBAMATE
AB Chlorpyrifos (CPF), an organophosphorus pesticide (OP), is one of the most widely used pesticides in the world. Subchronic exposures to CPF that do not cause cholinergic crisis are associated with problems in cognitive function (i.e., learning and memory deficits), but the biological mechanism(s) underlying this association remain speculative. To identify potential mechanisms of subchronic CPF neurotoxicity, adult male Long Evans (LE) rats were administered CPF at 3 or 10 mg/kg/d (s.c.) for 21 days. We quantified mRNA and non-coding RNA (ncRNA) expression profiles by RNA-seq, microarray analysis and small ncRNA sequencing technology in the CA1 region of the hippocampus. Hippocampal slice immunohistochemistry was used to determine CPF-induced changes in protein expression and localization patterns. Neither dose of CPF caused overt clinical signs of cholinergic toxicity, although after 21 days of exposure, cholinesterase activity was decreased to 58% or 13% of control levels in the hippocampus of rats in the 3 or 10 mg/kg/d groups, respectively. Differential gene expression in the CA1 region of the hippocampus was observed only in the 10 mg/kg/d dose group relative to controls. Of the 1382 differentially expressed genes identified by RNA-seq and microarray analysis, 67 were common to both approaches. Differential expression of six of these genes (Bdnf,Cort, Crhbp, Nptx2, Npy and Pnoc) was verified in an independent CPF exposure study; immunohistochemistry demonstrated that CRHBP and NPY were elevated in the CAl region of the hippocampus at 10 mg/kg/d CPF. Gene ontology enrichment analysis suggested association of these genes with receptor-mediated cell survival signaling pathways. miR132/212 was also elevated in the CAl hippocampal region, which may play a role in the disruption of neurotrophin-mediated cognitive processes after CPF administration. These findings identify potential mediators of CPF-induced neurobehavioral deficits following subchronic exposure to CPF at a level that inhibits hippocampal cholinesterase to less than 20% of control. An equally significant finding is that subchronic exposure to CPF at a level that produces more moderate inhibition of hippocampal cholinesterase (approximately 50% of control) does not produce a discernable change in gene expression. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY license.
C1 [Lee, Young S.; Hussainzada, Naissan] Oak Ridge Inst Sci & Engn, Oak Ridge, TN 37831 USA.
[Lee, Young S.; Lewis, John A.; Ippolito, Danielle L.; Hussainzada, Naissan; Jackson, David A.; Stallings, Jonathan D.] US Army, Ctr Environm Hlth Res USACEHR, Frederick, MD 21702 USA.
[Lein, Pamela J.] Univ Calif Davis, Sch Vet Med, Dept Mol Biosci, Davis, CA 95616 USA.
RP Stallings, JD (reprint author), US Army, Ctr Environm Hlth Res USACEHR, Frederick, MD 21702 USA.
EM jonathan.d.stallings.mil@mail.mil
OI Stallings, Jonathan/0000-0002-6430-5888
FU NIEHS NIH HHS [#ES016308, R01 ES016308]
NR 45
TC 1
Z9 2
U1 1
U2 7
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0300-483X
J9 TOXICOLOGY
JI Toxicology
PD JAN 18
PY 2016
VL 340
BP 53
EP 62
DI 10.1016/j.tox.2016.01.001
PG 10
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA DE8QS
UT WOS:000370902100007
PM 26775027
ER
PT J
AU Ratliff, ML
Mishra, M
Frank, MB
Guthridge, JM
Webb, CF
AF Ratliff, Michelle L.
Mishra, Meenu
Frank, Mark B.
Guthridge, Joel M.
Webb, Carol F.
TI The Transcription Factor ARID3a Is Important for In Vitro
Differentiation of Human Hematopoietic Progenitors
SO JOURNAL OF IMMUNOLOGY
LA English
DT Article
ID SYSTEMIC-LUPUS-ERYTHEMATOSUS; B-CELL DIFFERENTIATION; DNA-BINDING
PROTEINS; STEM-CELL; FACTOR BRIGHT; MYELOID LINEAGE; RINGER GENE;
V-REGION; FAMILY; EXPRESSION
AB We recently reported that the transcription factor ARID3a is expressed in a subset of human hematopoietic progenitor stem cells in both healthy individuals and in patients with systemic lupus erythematosus. Numbers of ARID3a(+) lupus hematopoietic stem progenitor cells were associated with increased production of autoreactive Abs when those cells were introduced into humanized mouse models. Although ARID3a/Bright knockout mice died in utero, they exhibited decreased numbers of hematopoietic stem cells and erythrocytes, indicating that ARID3a is functionally important for hematopoiesis in mice. To explore the requirement for ARID3a for normal human hematopoiesis, hematopoietic stem cell progenitors from human cord blood were subjected to both inhibition and overexpression of ARID3a in vitro. Inhibition of ARID3a resulted in decreased B lineage cell production accompanied by increases in cells with myeloid lineage markers. Overexpression of ARID3a inhibited both myeloid and erythroid differentiation. Additionally, inhibition of ARID3a in hematopoietic stem cells resulted in altered expression of transcription factors associated with hematopoietic lineage decisions. These results suggest that appropriate regulation of ARID3a is critical for normal development of both myeloid and B lineage pathways.
C1 [Ratliff, Michelle L.; Frank, Mark B.; Guthridge, Joel M.; Webb, Carol F.] Oklahoma Med Res Fdn, Oklahoma City, OK 73104 USA.
[Mishra, Meenu] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
[Webb, Carol F.] Univ Oklahoma, Hlth Sci Ctr, Dept Microbiol & Immunol, Oklahoma City, OK 73104 USA.
[Webb, Carol F.] Univ Oklahoma, Hlth Sci Ctr, Dept Cell Biol, Oklahoma City, OK 73104 USA.
RP Webb, CF (reprint author), Univ Oklahoma, Hlth Sci Ctr, Dept Med, Div Rheumatol, 800 Res Pkwy,Suite 418, Oklahoma City, OK 73104 USA.
EM carol-webb@ouhsc.edu
OI Webb, Carol/0000-0003-4164-9634
FU March of Dimes; National Institutes of Health [AI09043, AI044215, P30
AR053483, U19-AI062629-10]
FX This work was supported by the March of Dimes, National Institutes of
Health Grants AI09043 and AI044215 ( to C. F. W.), P30 AR053483
(Phenotyping Core support; to J. M. G.), and U19-AI062629-10 ( K. Mark
Coggeshall, principal investigator; pilot, to C.F.W.).
NR 65
TC 1
Z9 1
U1 0
U2 2
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD JAN 15
PY 2016
VL 196
IS 2
BP 614
EP 623
DI 10.4049/jimmunol.1500355
PG 10
WC Immunology
SC Immunology
GA DA8QX
UT WOS:000368072100018
PM 26685208
ER
PT J
AU Welch, RD
Ayaz, SI
Lewis, LM
Unden, J
Chen, JY
Mika, VH
Saville, B
Tyndall, JA
Nash, M
Buki, A
Barzo, P
Hack, D
Tortella, FC
Schmid, K
Hayes, RL
Vossough, A
Sweriduk, ST
Bazarian, JJ
AF Welch, Robert D.
Ayaz, Syed I.
Lewis, Lawrence M.
Unden, Johan
Chen, James Y.
Mika, Valerie H.
Saville, Ben
Tyndall, Joseph A.
Nash, Marshall
Buki, Andras
Barzo, Pal
Hack, Dallas
Tortella, Frank C.
Schmid, Kara
Hayes, Ronald L.
Vossough, Arastoo
Sweriduk, Stephen T.
Bazarian, Jeffrey J.
TI Ability of Serum Glial Fibrillary Acidic Protein, Ubiquitin C-Terminal
Hydrolase-L1, and S100B To Differentiate Normal and Abnormal Head
Computed Tomography Findings in Patients with Suspected Mild or Moderate
Traumatic Brain Injury
SO JOURNAL OF NEUROTRAUMA
LA English
DT Article
ID NEW-ORLEANS CRITERIA; INTRACRANIAL LESIONS; NEUROSURGICAL INTERVENTION;
RULE; BIOMARKERS; MANAGEMENT; S100-BETA; DIAGNOSIS; ACCURACY; BLOOD
AB Head computed tomography (CT) imaging is still a commonly obtained diagnostic test for patients with minor head injury despite availability of clinical decision rules to guide imaging use and recommendations to reduce radiation exposure resulting from unnecessary imaging. This prospective multicenter observational study of 251 patients with suspected mild to moderate traumatic brain injury (TBI) evaluated three serum biomarkers' (glial fibrillary acidic protein [GFAP], ubiquitin C-terminal hydrolase-L1 [UCH-L1] and S100B measured within 6h of injury) ability to differentiate CT negative and CT positive findings. Of the 251 patients, 60.2% were male and 225 (89.6%) had a presenting Glasgow Coma Scale score of 15. A positive head CT (intracranial injury) was found in 36 (14.3%). UCH-L1 was 100% sensitive and 39% specific at a cutoff value >40pg/mL. To retain 100% sensitivity, GFAP was 0% specific (cutoff value 0pg/mL) and S100B had a specificity of only 2% (cutoff value 30pg/mL). All three biomarkers had similar values for areas under the receiver operator characteristic curve: 0.79 (95% confidence interval; 0.70-0.88) for GFAP, 0.80 (0.71-0.89) for UCH-L1, and 0.75 (0.65-0.85) for S100B. Neither GFAP nor UCH-L1 curve values differed significantly from S100B (p=0.21 and p=0.77, respectively). In our patient cohort, UCH-L1 outperformed GFAP and S100B when the goal was to reduce CT use without sacrificing sensitivity. UCH-L1 values <40pg/mL could potentially have aided in eliminating 83 of the 215 negative CT scans. These results require replication in other studies before the test is used in actual clinical practice.
C1 [Welch, Robert D.; Ayaz, Syed I.; Mika, Valerie H.] Wayne State Univ, Dept Emergency Med, Detroit, MI 48230 USA.
[Lewis, Lawrence M.] Washington Univ, Dept Emergency Med, St Louis, MO USA.
[Unden, Johan] Clin Sci Malmo, Dept Anesthesiol & Intens Care, Malmo, Sweden.
[Chen, James Y.] Univ Calif San Diego Hlth Syst, Dept Radiol, San Diego, CA USA.
[Saville, Ben] Berry Consultants, Austin, TX USA.
[Tyndall, Joseph A.] Univ Florida, Dept Emergency Med, Gainesville, FL USA.
[Nash, Marshall] Neurostudies Net, Decatur, GA USA.
[Buki, Andras] Univ Pecs, Dept Neurosurg, Pecs, Hungary.
[Barzo, Pal] Univ Szeged, Dept Neurosurg, Szeged, Hungary.
[Hack, Dallas] US Army, Med Res & Mat Command, Ft Detrick, MD USA.
[Tortella, Frank C.] Walter Reed Army Inst Res, Appl Neurobiol, Silver Spring, MD USA.
[Schmid, Kara] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA.
[Hayes, Ronald L.] Banyan Biomarkers Inc, Ctr Innovat Res, Alachua, FL USA.
[Vossough, Arastoo] Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA.
[Sweriduk, Stephen T.] Shields Hlth Care Grp, Dept Radiol, Brockton, MA USA.
[Bazarian, Jeffrey J.] Univ Rochester, Sch Med, Dept Emergency Med, Rochester, NY USA.
RP Welch, RD (reprint author), Wayne State Univ, Dept Emergency Med, Detroit, MI 48230 USA.
EM rwelch@med.wayne.edu
FU U.S. Army Medical Research and Material Command [W81XWH-06-1-0517,
W81XWH-10-C-0251]
FX This work is supported by the U.S. Army Medical Research and Material
Command under Contract N. W81XWH-06-1-0517 and Contract N.
W81XWH-10-C-0251. The views, opinions and/or findings contained in this
report are those of the authors and should not be construed as an
official Department of the Army position, policy or decision unless so
designated by other documentation.
NR 33
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Z9 4
U1 1
U2 7
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD JAN 15
PY 2016
VL 33
IS 2
BP 203
EP 214
DI 10.1089/neu.2015.4149
PG 12
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA DA7PH
UT WOS:000367995800006
PM 26467555
ER
PT J
AU Munday, LB
Crone, JC
Knap, J
AF Munday, Lynn B.
Crone, Joshua C.
Knap, Jaroslaw
TI Prismatic and helical dislocation loop generation from defects
SO ACTA MATERIALIA
LA English
DT Article
DE Dislocation dynamics; Void growth; Image stress
ID VOID GROWTH; DYNAMICS SIMULATIONS; MODEL; DEFORMATION; INCLUSION;
CRYSTALS
AB Plastic deformation induced by stress concentrations near crystal defects occurs through the generation of prismatic dislocation loops (PDL). The production of PDLs leads to void growth and particle decoherence. In this work we use dislocation dynamics simulations to characterize two mechanisms for PDL formation. The first mechanism corresponds to a classical model of PDL generation from dislocation nucleation. The second mechanism considers PDL generation through cross-slip of a screw dislocation intersecting the particle. We systematically study the effect of the crystal lattice and defect type on PDL generation for both mechanisms as a function of pressure. The simulations show image stresses produced by the dislocation's interaction with the free surface of a void suppresses PDL generation. The highest PDL generation rates are found for a dislocation nucleated from a void in a body-centered cubic lattice. Our simulations also show helical coiling of screw dislocations produces a continuous emission of PDLs without the need for dislocation nucleation at pressures as low as 1.0 GPa. Published by Elsevier Ltd on behalf of Acta Materialia Inc.
C1 [Munday, Lynn B.; Crone, Joshua C.; Knap, Jaroslaw] US Army Res Lab, RDRL CIH C, Aberdeen Proving Ground, MD 21005 USA.
RP Munday, LB (reprint author), US Army Res Lab, RDRL CIH C, Aberdeen Proving Ground, MD 21005 USA.
EM lynn.b.munday.civ@mail.mil
FU U.S. Army Research Laboratory's Enterprise for Multiscale Research of
Materials
FX Support of the U.S. Army Research Laboratory's Enterprise for Multiscale
Research of Materials is gratefully acknowledged. Computing support was
provided by the DoD Supercomputing Resource Center located at the U.S.
Army Research Laboratory.
NR 33
TC 1
Z9 1
U1 5
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1359-6454
EI 1873-2453
J9 ACTA MATER
JI Acta Mater.
PD JAN 15
PY 2016
VL 103
BP 217
EP 228
DI 10.1016/j.actamat.2015.09.056
PG 12
WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical
Engineering
SC Materials Science; Metallurgy & Metallurgical Engineering
GA DA2MU
UT WOS:000367630500022
ER
PT J
AU Son, HK
Sivakumar, S
Rood, MJ
Kim, BJ
AF Son, H. K.
Sivakumar, S.
Rood, M. J.
Kim, B. J.
TI Electrothermal adsorption and desorption of volatile organic compounds
on activated carbon fiber cloth
SO JOURNAL OF HAZARDOUS MATERIALS
LA English
DT Article
DE Adsorption; Desorption; Activated carbon fiber cloth; Volatile organic
compounds; Set-point concentration
ID AIR-POLLUTION CONTROL; SWING ADSORPTION; CRYOGENIC CONDENSATION;
BIOTRICKLING FILTERS; LOAD EQUALIZATION; BENZENE VAPORS; REMOVAL;
PERFORMANCE; STREAMS; TOLUENE
AB Adsorption is an effective means to selectively remove volatile organic compounds (VOCs) from industrial gas streams and is particularly of use for gas streams that exhibit highly variable daily concentrations of VOCs. Adsorption of such gas streams by activated carbon fiber cloths (ACFCs) and subsequent controlled desorption can provide gas streams of well-defined concentration that can then be more efficiently treated by biofiltration than streams exhibiting large variability in concentration. In this study, we passed VOC-containing gas through an ACFC vessel for adsorption and then desorption in a concentration-controlled manner via electrothermal heating. Set-point concentrations (40-900 ppm(v)) and superficial gas velocity (6.3-9.9 m/s) were controlled by a data acquisition and control system. The results of the average VOC desorption, desorption factor and VOC in-and-out ratio were calculated and compared for various gas set-point concentrations and superficial gas velocities. Our results reveal that desorption is strongly dependent on the set-point concentration and that the VOC desorption rate can be successfully equalized and controlled via an electrothermal adsorption system. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Son, H. K.] Kosin Univ, Dept Hlth & Environm, Busan, South Korea.
[Sivakumar, S.] Pusan Natl Univ, Coll Nat Resource & Life Sci, Dept Bioenvironm Energy, Miryang Si 627706, Gyeongsangnam D, South Korea.
[Rood, M. J.] Univ Illinois, Dept Civil & Environm Engn, Urbana, IL 61801 USA.
[Kim, B. J.] US Army Engineer Res & Dev Ctr ERDC CERL, Construct Engn Res Lab, Champaign, IL USA.
RP Sivakumar, S (reprint author), Pusan Natl Univ, Coll Nat Resource & Life Sci, Dept Bioenvironm Energy, Miryang Si 627706, Gyeongsangnam D, South Korea.
EM ssivaphd@yahoo.com
FU Korea Environmental Industry and Technology Institute
FX This work was financially supported by the Korea Environmental Industry
and Technology Institute.
NR 43
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Z9 6
U1 29
U2 127
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0304-3894
EI 1873-3336
J9 J HAZARD MATER
JI J. Hazard. Mater.
PD JAN 15
PY 2016
VL 301
BP 27
EP 34
DI 10.1016/j.jhazmat.2015.08.040
PG 8
WC Engineering, Environmental; Engineering, Civil; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA CZ9GY
UT WOS:000367407200004
PM 26342148
ER
PT J
AU Fraga, M
Vilarino, N
Louzao, MC
Fernandez, DA
Poli, M
Botana, LM
AF Fraga, Maria
Vilarino, Natalia
Carmen Louzao, M.
Fernandez, Diego A.
Poli, Mark
Botana, Luis M.
TI Detection of palytoxin-like compounds by a flow cytometry-based
immunoassay supported by functional and analytical methods
SO ANALYTICA CHIMICA ACTA
LA English
DT Article
DE Palytoxin; Palytoxin-like molecules; Microsphere-based array;
Flow-cytometry system; Screening method
ID SHELLFISH POISONING TOXINS; OSTREOPSIS-CF. SIAMENSIS; OF-THE-ART;
MASS-SPECTROMETRY; 1ST EVIDENCE; OVATOXIN-A; ANALOGS; SYSTEM; ASSAY;
INHIBITION
AB Palytoxin (PLTX) is a complex marine toxin produced by zoanthids (i.e. Palythoa), dinoflagellates (Ostreopsis) and cyanobacteria (Trichodesmium). PLTX outbreaks are usually associated with Indo-Pacific waters, however their recent repeated occurrence in Mediterranean-European Atlantic coasts demonstrate their current worldwide distribution. Human sickness and fatalities have been associated with toxic algal blooms and ingestion of seafood contaminated with PLTX-like molecules. These toxins represent a serious threat to human health. There is an immediate need to develop easy-to-use, rapid detection methods due to the lack of validated protocols for their detection and quantification. We have developed an immuno-detection method for PLTX-like molecules based on the use of microspheres coupled to flow-cytometry detection (Luminex 200 (TM)). The assay consisted of the competition between free PLTX-like compounds in solution and PLTX immobilized on the surface of microspheres for binding to a specific monoclonal anti-PLTX antibody. This method displays an IC50 of 1.83 +/- 0.21 nM and a dynamic range of 0.47-6.54 nM for PLTX. An easy-to-perform extraction protocol, based on a mixture of methanol and acetate buffer, was applied to spiked mussel samples providing a recovery rate of 104 +/- 8% and a range of detection from 374 +/- 81 to 4430 +/- 150 mu g kg(-1) when assayed with this method. Extracts of Ostreopsis cf. siamensis and Palythoa tuberculosa were tested and yielded positive results for PLTX-like molecules. However, the data obtained for the coral sample suggested that this antibody did not detect 42-OH-PLTX efficiently. The same samples were further analyzed using a neuroblastoma cytotoxicity assay and UPLC-IT-TOF spectrometry, which also pointed to the presence of PLTX-like compounds. Therefore, this single detection method for PLTX provides a semi-quantitative tool useful for the screening of PLTX-like molecules in different matrixes. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Fraga, Maria; Vilarino, Natalia; Carmen Louzao, M.; Fernandez, Diego A.; Botana, Luis M.] Univ Santiago de Compostela, Fac Vet, Dept Farmacol, Lugo 27002, Spain.
[Poli, Mark] US Army Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD USA.
RP Vilarino, N (reprint author), Fac Vet, Dept Farmacol, Campus Univ, Lugo 27002, Spain.
EM natalia.vilarino@usc.es; luis.botana@usc.es
RI Fernandez Martinez, Diego Alberto/A-7663-2011;
OI Fernandez Martinez, Diego Alberto/0000-0002-3336-5036; Vilarino,
Natalia/0000-0001-6055-6359; Louzao, M. Carmen/0000-0002-3072-0637
FU FEDER; CDTI and Technological Funds - Ministerio de Economia y
Competitividad, [AGL2012-40185-CO2-01, AGL2014-58210-R]; Conselleria de
Cultura, Educacion e Ordenacion Universitaria [GRC2013-016]; Axencia
Galega de Innovacion, Spain [ITC-20133020 SINTOX]; CDTI under ISIP
Programme, Spain [IDI-20130304 APTAFOOD]; European Union's Seventh
Framework Programme [312184 PHARMASEA]
FX The research leading to these results has received funding from the
following FEDER cofunded-grants. From CDTI and Technological Funds,
supported by Ministerio de Economia y Competitividad,
AGL2012-40185-CO2-01, AGL2014-58210-R, and Conselleria de Cultura,
Educacion e Ordenacion Universitaria, GRC2013-016, and through Axencia
Galega de Innovacion, Spain, ITC-20133020 SINTOX. From CDTI under ISIP
Programme, Spain, IDI-20130304 APTAFOOD. From the European Union's
Seventh Framework Programme managed by REA-Research Executive Agency
(FP7/2007-2013) under grant agreement 312184 PHARMASEA.
NR 49
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U1 3
U2 22
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0003-2670
EI 1873-4324
J9 ANAL CHIM ACTA
JI Anal. Chim. Acta
PD JAN 15
PY 2016
VL 903
BP 1
EP 12
DI 10.1016/j.aca.2015.09.040
PG 12
WC Chemistry, Analytical
SC Chemistry
GA CZ3ZY
UT WOS:000367043900001
PM 26709295
ER
PT J
AU Zander, Z
Yagloski, R
DeCoste, J
Zhang, DJ
DeLacy, BG
AF Zander, Zachary
Yagloski, Raymond
DeCoste, Jared
Zhang, Dajie
DeLacy, Brendan G.
TI One-pot synthesis of high aspect ratio titanium dioxide nanorods using
oxalic acid as a complexing agent
SO MATERIALS LETTERS
LA English
DT Article
DE TiO2; nanorods; titanium isopropoxide; oxalic acid; hydrothermal
synthesis; one-pot synthesis
ID NANOTUBE ARRAYS; OXIDE NANOTUBE; TIO2 NANOTUBES; NANOCRYSTALS;
MECHANISMS
AB We report the novel one-pot synthesis of high aspect ratio titanium dioxide (TiO2) nanorods using a simple hydrothermal technique. Specifically, oxalic acid and sodium hydroxide (NaOH) were used as additives to promote the conversion of titanium tetraisopropoxide (TTIP) into a one-dimensional TiO2 morphology. All resultant products were characterized by X-ray powder diffraction and scanning electron microscopy. Influential factors on the growth mechanisms of TiO2 nanorods are discussed. This approach contrasts the typical approach of using spherical TiO2 as a starting material in the fabrication of one-dimensional TiO2 structures, and instead allows for the direct synthesis of TiO2 nanorods from TTIP precursors. Published by Elsevier B.V.
C1 [Zander, Zachary; Yagloski, Raymond; DeCoste, Jared; DeLacy, Brendan G.] US Army Edgewood Chem Biol Ctr, Res & Technol Directorate, Aberdeen Proving Ground, MD 21010 USA.
[DeCoste, Jared] Leidos Inc, Gunpowder, MD 21010 USA.
[Zhang, Dajie] Brimrose Technol Corp, Sparks, MD 21152 USA.
RP DeLacy, BG (reprint author), US Army Edgewood Chem Biol Ctr, Res & Technol Directorate, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA.
EM brendan.g.delacy.civ@mail.mil
FU Department of the Army Basic Research Program; Edgewood Chemical
Biological Center
FX This research was funded by the Department of the Army Basic Research
Program and sponsored by the Edgewood Chemical Biological Center.
NR 25
TC 1
Z9 1
U1 5
U2 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0167-577X
EI 1873-4979
J9 MATER LETT
JI Mater. Lett.
PD JAN 15
PY 2016
VL 163
BP 39
EP 42
DI 10.1016/j.matlet.2015.10.041
PG 4
WC Materials Science, Multidisciplinary; Physics, Applied
SC Materials Science; Physics
GA CY0FI
UT WOS:000366081400011
ER
PT J
AU Terzic, N
Konstantinovic, J
Tot, M
Burojevic, J
Djurkovic-Djakovic, O
Srbljanovic, J
Stajner, T
Verbic, T
Zlatovic, M
Machado, M
Albuquerque, IS
Prudencio, M
Sciotii, RJ
Pecic, S
D'Alessandro, S
Taramelli, D
Solaja, BA
AF Terzic, Natasa
Konstantinovic, Jelena
Tot, Miklos
Burojevic, Jovana
Djurkovic-Djakovic, Olgica
Srbljanovic, Jelena
Stajner, Tijana
Verbic, Tatjana
Zlatovic, Mario
Machado, Marta
Albuquerque, Ines S.
Prudencio, Miguel
Sciotii, Richard J.
Pecic, Stevan
D'Alessandro, Sarah
Taramelli, Donatella
Solaja, Bogdan A.
TI Reinvestigating Old Pharmacophores: Are 4-Aminoquinolines and
Tetraoxanes Potential Two-Stage Antimalarials?
SO JOURNAL OF MEDICINAL CHEMISTRY
LA English
DT Article
ID PLASMODIUM-FALCIPARUM MALARIA; CHLOROQUINE-RESISTANCE TRANSPORTER; LIVER
STAGE; IN-VITRO; ANTIPLASMODIAL ACTIVITY; ARTEMISININ RESISTANCE;
HYBRIDS SYNTHESIS; DRUGS; DERIVATIVES; ANALOGS
AB The syntheses and antiplasmodial activities of various substituted aminoquinolines coupled to an adamantane carrier are described. The compounds exhibited pronounced in vitro and in vivo activity against Plasmodium berghei in the Thompson test. Tethering a fluorine atom to the aminoquinoline C(3) position afforded fluoroaminoquinolines that act as intrahepatocytic parasite inhibitors, with compound 25 having an IC50 = 0.31 mu M and reducing the liver load in mice by up to 92% at 80 mg/kg dose. Screening our peroxides as inhibitors of liver stage infection revealed that the tetraoxane pharmacophore itself is also an excellent liver stage P. berghei inhibitor (78: IC50 = 0.33 mu M). Up to 91% reduction of the parasite liver load in mice was achieved at 100 mg/kg. Examination of tetraoxane 78 against the transgenic 3D7 strain expressing luciferase under a gametocyte-specific promoter revealed its activity against stage IV-V Plasmodium falciparum gametocytes (IC50 = 1.16 +/- 0.37 mu M). To the best of our knowledge, compounds 25 and 78 are the first examples of either an 4-aminoquinoline or a tetraoxane liver stage inhibitors.
C1 [Terzic, Natasa] Inst Chem Technol & Met, Belgrade 11000, Serbia.
[Konstantinovic, Jelena; Tot, Miklos; Burojevic, Jovana; Verbic, Tatjana; Zlatovic, Mario; Solaja, Bogdan A.] Univ Belgrade, Fac Chem, Studentski Trg 16,POB 51, Belgrade 11158, Serbia.
[Djurkovic-Djakovic, Olgica; Srbljanovic, Jelena; Stajner, Tijana] Univ Belgrade, Inst Med Res, Dr Subotica 4, Belgrade 11129, Serbia.
[Machado, Marta; Albuquerque, Ines S.; Prudencio, Miguel] Univ Lisbon, Inst Med Mol, Fac Med, P-1649028 Lisbon, Portugal.
[Sciotii, Richard J.] Walter Reed Army Inst Res, Expt Therapeut Branch, Silver Spring, MD 20910 USA.
[Pecic, Stevan] Columbia Univ, Dept Med, Div Expt Therapeut, New York, NY 10032 USA.
[D'Alessandro, Sarah; Taramelli, Donatella] Univ Milan, Dipartimento Sci Farmacol & Biomol, I-20133 Milan, Italy.
RP Solaja, BA (reprint author), Univ Belgrade, Fac Chem, Studentski Trg 16,POB 51, Belgrade 11158, Serbia.; Prudencio, M (reprint author), Univ Lisbon, Inst Med Mol, Fac Med, P-1649028 Lisbon, Portugal.
EM mprudencio@medicina.ulisboa.pt; bsolaja@chem.bg.ac.rs
RI Zlatovic, Mario/E-5874-2015; Albuquerque, Ines/P-5325-2016; Verbic,
Tatjana/Q-3529-2016; Konstantinovic, Jelena/Q-5813-2016;
OI Zlatovic, Mario/0000-0003-4311-1731; Albuquerque,
Ines/0000-0002-1108-0961; Verbic, Tatjana/0000-0002-6348-1644;
Konstantinovic, Jelena/0000-0002-2572-8538; Pecic,
Stevan/0000-0002-3706-8768; Solaja, Bogdan/0000-0002-9975-2725
FU Ministry of Science and Technological Development of Serbia [172008,
41019]; Serbian Academy of Sciences and Arts; Fundacao para a Ciencia e
Tecnologia, Portugal [PTDC/SAUMIC/117060/2010]; Bill & Melinda Gates
Foundation [OPP1040394]
FX This research was supported by The Ministry of Science and Technological
Development of Serbia (grant nos. 172008 and 41019), the Serbian Academy
of Sciences and Arts, Fundacao para a Ciencia e Tecnologia, Portugal
(grant PTDC/SAUMIC/117060/2010), the Bill & Melinda Gates Foundation
(grant OPP1040394). The contents of this manuscript have been reviewed
by the Walter Reed Army Institute of Research. There is no objection to
its presentation or publication.
NR 83
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Z9 1
U1 4
U2 19
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0022-2623
EI 1520-4804
J9 J MED CHEM
JI J. Med. Chem.
PD JAN 14
PY 2016
VL 59
IS 1
BP 264
EP 281
DI 10.1021/acs.jmedchem.5b01374
PG 18
WC Chemistry, Medicinal
SC Pharmacology & Pharmacy
GA DB5OV
UT WOS:000368564400019
PM 26640981
ER
PT J
AU Owens, BD
Garcia, EJ
Alitz, CJ
AF Owens, Brett D.
Garcia, EStephan J.
Alitz, Curt J.
TI FASCIOTOMY FOR CHRONIC EXERTIONAL COMPARTMENT SYNDROME OF THE LEG
SO JBJS ESSENTIAL SURGICAL TECHNIQUES
LA English
DT Editorial Material
C1 [Owens, Brett D.] Brown Univ, Alpert Med Sch, 100 Butler Dr, Providence, RI 02906 USA.
[Garcia, EStephan J.; Alitz, Curt J.] Keller Army Hosp, West Point, NY 10996 USA.
RP Owens, BD (reprint author), Brown Univ, Alpert Med Sch, 100 Butler Dr, Providence, RI 02906 USA.
NR 2
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2160-2204
J9 JBJS ESSENT SURG TEC
JI JBJS Essent. Surg. Tech.
PD JAN 13
PY 2016
VL 6
IS 1
AR e1
DI 10.2106/JBJS.ST.N.00118
PG 2
WC Surgery
SC Surgery
GA DG6LX
UT WOS:000372197300001
ER
PT J
AU Li, Y
Ho, J
Wang, JC
Li, ZM
Zhong, GJ
Zhu, L
AF Li, Yue
Ho, Janet
Wang, Jianchuan
Li, Zhong-Ming
Zhong, Gan-Ji
Zhu, Lei
TI Understanding Nonlinear Dielectric Properties in a Biaxially Oriented
Poly(vinylidene fluoride) Film at Both Low and High Electric Fields
SO ACS APPLIED MATERIALS & INTERFACES
LA English
DT Article
DE poly(vinylidene fluoride); ferroelectric; nonlinear dielectric property;
high-voltage broadband dielectric spectroscopy; dipolar relaxation
ID FERROELECTRIC POLYMERS; VINYLIDENE FLUORIDE; EFFECT TRANSISTORS;
COPOLYMER; TRIFLUOROETHYLENE; RELAXATIONS; HYSTERESIS; ACTUATORS;
CRYSTALS; ACETATE
AB Understanding nonlinear dielectric behavior in polar polymers is crucial to their potential application as next generation high energy density and low loss dielectrics. In this work, we studied nonlinear dielectric properties of a biaxially oriented poly(vinylidene fluoride) (BOPVDF) film under both low and high electric fields. For fundamental nonlinear dielectric constants at low fields (<30 MV/m), Novocontrol high-voltage broadband dielectric spectroscopy (HVBDS) was accurate enough to measure up to the third harmonics. It was observed that the low-field dielectric nonlinearity for the BOPVDF disappeared above 10 Hz at room temperature, suggesting that the low-field dielectric nonlinearity originated from ionic migration of impurity ions rather than dipolar relaxation of the amorphous segments. Above the coercive field (E-C approximate to 70 MV/m), bipolar electric displacement-electric field (D-E) loop tests were used to extract the nonlinear behavior for pure PVDF crystals, which had a clear origin of ferroelectric switching of polar crystalline dipoles and domains and nonpolar-to-polar (alpha -> delta -> beta) phase transformations. By using HVBDS, it was observed that the ferroelectric switching of polar crystalline dipoles and domains in BOPVDF above the E-C always took place between 20 and 500 Hz regardless of a broad range of temperature from -30 to 100 degrees C. This behavior was drastically different from that of the amorphous PVDF dipoles, which had a strong dependence on frequency over orders of magnitude.
C1 [Li, Yue; Wang, Jianchuan; Li, Zhong-Ming; Zhong, Gan-Ji] Sichuan Univ, Coll Polymer Sci & Engn, State Key Lab Polymer Mat Engn, Chengdu 610065, Sichuan, Peoples R China.
[Li, Yue; Zhu, Lei] Case Western Reserve Univ, Dept Macromol Sci & Engn, Cleveland, OH 44106 USA.
[Ho, Janet] US Army, Res Lab, RDRL SED C, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
[Wang, Jianchuan] Chongqing Univ, Coll Chem & Chem Engn, Chongqing 400044, Peoples R China.
RP Wang, JC (reprint author), Sichuan Univ, Coll Polymer Sci & Engn, State Key Lab Polymer Mat Engn, Chengdu 610065, Sichuan, Peoples R China.; Zhu, L (reprint author), Case Western Reserve Univ, Dept Macromol Sci & Engn, Cleveland, OH 44106 USA.; Wang, JC (reprint author), Chongqing Univ, Coll Chem & Chem Engn, Chongqing 400044, Peoples R China.
EM jxw319@cqu.edu.cn; lxz121@case.edu
RI Li, Zhong-Ming/I-9785-2016; Zhu, Lei/C-8754-2013
OI Zhu, Lei/0000-0001-6570-9123
FU National Science Foundation [DMR-1402733]; China Scholarship Council;
National Natural Science Foundation of China [51528302]; Army Research
Office (ARO) [W911NF-13-1-0153]
FX This work is supported by National Science Foundation (DMR-1402733).
Y.L. and J.W. acknowledge financial support from China Scholarship
Council. Partial support from the National Natural Science Foundation of
China (Grant No. 51528302) is also acknowledged. The HVBDS instrument is
supported by Army Research Office (ARO) under Award No.
W911NF-13-1-0153.
NR 38
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Z9 4
U1 17
U2 48
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1944-8244
J9 ACS APPL MATER INTER
JI ACS Appl. Mater. Interfaces
PD JAN 13
PY 2016
VL 8
IS 1
BP 455
EP 465
DI 10.1021/acsami.5b09368
PG 11
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary
SC Science & Technology - Other Topics; Materials Science
GA DB5OH
UT WOS:000368563000056
PM 26698912
ER
PT J
AU Becker, CR
Prokes, SM
Love, CT
AF Becker, Collin R.
Prokes, S. M.
Love, Corey T.
TI Enhanced Lithiation Cycle Stability of ALD-Coated Confined a-Si
Microstructures Determined Using In Situ AFM
SO ACS APPLIED MATERIALS & INTERFACES
LA English
DT Article
DE silicon; lithium ion; atomic force microscopy; in situ; battery
ID LITHIUM-ION BATTERIES; ATOMIC LAYER DEPOSITION; AMORPHOUS-SILICON;
ELECTROLYTE ADDITIVES; VINYLENE CARBONATE; FORCE MICROSCOPY; POUCH
CELLS; ANODES; PERFORMANCE; NANOPARTICLES
AB Microfabricated amorphous silicon (alpha-Si) pits similar to 4 mu m in diameter and 100 nm thick were fabricated to be partially confined in a nickel (Ni) current collector. Corresponding unconfined pillars were also fabricated. The samples were coated with 1.5, 3, or 6 nm of Al2O3 ALD. These samples were tested in electrolytes of 3:7 by weight ethylene carbonate:ethyl methyl carbonate (EC:EMC) with 1.2 M LiPF6 salt with and without 2% fluoroethylene carbonate (FEC) and in a pure FEC electrolyte with 10 wt % LiPF6. The samples were imaged with an atomic force microscope during electrochemical cycling to evaluate morphology evolution and solid electrolyte interphase (SEI) formation. The partially confined alpha-Si structures had superior cycle efficiency relative to the unconfined alpha-Si pillars. Additionally, samples with 3 nm of ALD achieved higher charge capacity and enhanced cycle life compared to samples without ALD, demonstrated thinner SEI formation, and after 10 cycles at a 1 C rate remained mostly intact and had actually decreased in diameter. Finally, the samples with 3 nm of ALD had better capacity retention in the baseline 3:7 EC:EMC than in either of the FEC containing electrolytes.
C1 [Becker, Collin R.] US Army, Res Lab, Electrochem Branch, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
[Prokes, S. M.] US Navy, Res Lab, Elect Sci & Technol Div, Washington, DC 20375 USA.
[Love, Corey T.] US Navy, Res Lab, Div Chem, Washington, DC 20375 USA.
RP Becker, CR (reprint author), US Army, Res Lab, Electrochem Branch, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM Collin.r.becker.civ@mail.mil
FU US Army Research Lab; Nanoscience Institute at the US Naval Research Lab
FX We are grateful for financial support from the US Army Research Lab and
Nanoscience Institute at the US Naval Research Lab. We thank John
Moulder from PHI for the XPS measurements and Sam Delp from the US Army
Research Lab for providing electrolytes.
NR 37
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U1 19
U2 65
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1944-8244
J9 ACS APPL MATER INTER
JI ACS Appl. Mater. Interfaces
PD JAN 13
PY 2016
VL 8
IS 1
BP 530
EP 537
DI 10.1021/acsami.5b09544
PG 8
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary
SC Science & Technology - Other Topics; Materials Science
GA DB5OH
UT WOS:000368563000064
PM 26672626
ER
PT J
AU Frei, JC
Nyakatura, EK
Zak, SE
Bakken, RR
Chandran, K
Dye, JM
Lai, JR
AF Frei, Julia C.
Nyakatura, Elisabeth K.
Zak, Samantha E.
Bakken, Russell R.
Chandran, Kartik
Dye, John M.
Lai, Jonathan R.
TI Bispecific Antibody Affords Complete Post-Exposure Protection of Mice
from Both Ebola (Zaire) and Sudan Viruses
SO SCIENTIFIC REPORTS
LA English
DT Article
ID ENVELOPE GLYCOPROTEIN; NONHUMAN-PRIMATES; MONOCLONAL-ANTIBODIES;
SYNTHETIC ANTIBODIES; CRYSTAL-STRUCTURE; INFECTION; PROPHYLAXIS;
DISEASE; MODEL; GP2
AB Filoviruses (Ebola and Marburg) cause severe hemorrhagic fever. There are five species of ebolavirus; among these, the Ebola (Zaire) and Sudan viruses (EBOV and SUDV, respectively) are highly pathogenic and have both caused recurring, large outbreaks. However, the EBOV and SUDV glycoprotein (GP) sequences are 45% divergent and thus antigenically distinct. Few antibodies with cross-neutralizing properties have been described to date. We used antibody engineering to develop novel bispecific antibodies (Bis-mAbs) that are cross-reactive toward base epitopes on GP from EBOV and SUDV. These Bis-mAbs exhibit potent neutralization against EBOV and SUDV GP pseudotyped viruses as well as authentic pathogens, and confer a high degree (in one case 100%) post-exposure protection of mice from both viruses. Our studies show that a single agent that targets the GP base epitopes is sufficient for protection in mice; such agents could be included in panfilovirus therapeutic antibody cocktails.
C1 [Frei, Julia C.; Nyakatura, Elisabeth K.; Lai, Jonathan R.] Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA.
[Zak, Samantha E.; Bakken, Russell R.; Dye, John M.] US Army, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA.
[Chandran, Kartik] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA.
RP Dye, JM (reprint author), US Army, Med Res Inst Infect Dis, Div Virol, 1425 Porter St, Ft Detrick, MD 21702 USA.
EM john.m.dye1.civ@mail.mil; jon.lai@einstein.yu.edu
FU NIH [U19 AI109762]; Irma T. Hirschl/Monique Weill-Caulier Research
Scientist Award; NIH Cellular and Molecular Biology and Genetics
Training Program [T32-GM007491]; DAAD (Deutscher Akademischer Austausch
Dienst, German Academic Exchange Service); JSTO-DTRA project [CB3948]
FX This work was supported by NIH grant U19 AI109762 (Centers for
Excellence in Translational Research) to K.C., J.M.D. and J.R.L. and by
an Irma T. Hirschl/Monique Weill-Caulier Research Scientist Award to
J.R. L.J.C.F. was supported by NIH Cellular and Molecular Biology and
Genetics Training Program T32-GM007491 and E.K.N. by a DAAD (Deutscher
Akademischer Austausch Dienst, German Academic Exchange Service)
fellowship. J.M.D. kindly acknowledges JSTO-DTRA project CB3948 for
support Opinions, conclusions, interpretations, and recommendations are
those of the authors and are not necessarily endorsed by the US. Army.
The mention of trade names or commercial products does not constitute
endorsement or recommendation for use by the Department of the Army or
the Department of Defense.
NR 44
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U1 3
U2 13
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JAN 13
PY 2016
VL 6
AR 19193
DI 10.1038/srep19193
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DA9BO
UT WOS:000368101700001
PM 26758505
ER
PT J
AU Watanabe, KH
Mayo, M
Jensen, KM
Villeneuve, DL
Ankley, GT
Perkins, EJ
AF Watanabe, Karen H.
Mayo, Michael
Jensen, Kathleen M.
Villeneuve, Daniel L.
Ankley, Gerald T.
Perkins, Edward J.
TI Predicting Fecundity of Fathead Minnows (Pimephales promelas) Exposed to
Endocrine-Disrupting Chemicals Using a MATLAB (R)-Based Model of Oocyte
Growth Dynamics
SO PLOS ONE
LA English
DT Article
ID TERM REPRODUCTION ASSAY; PITUITARY-GONADAL AXIS; COMPUTATIONAL MODEL;
FISH; INHIBITOR; 17-BETA-TRENBOLONE; STEROIDOGENESIS; ECOTOXICOLOGY;
BIOSYNTHESIS; KETOCONAZOLE
AB Fish spawning is often used as an integrated measure of reproductive toxicity, and an indicator of aquatic ecosystem health in the context of forecasting potential population-level effects considered important for ecological risk assessment. Consequently, there is a need for flexible, widely-applicable, biologically-based models that can predict changes in fecundity in response to chemical exposures, based on readily measured biochemical endpoints, such as plasma vitellogenin (VTG) concentrations, as input parameters. Herein we describe a MATLAB1 version of an oocyte growth dynamics model for fathead minnows (Pimephales promelas) with a graphical user interface based upon a previously published model developed with MCSim software and evaluated with data from fathead minnows exposed to an androgenic chemical, 17 beta-trenbolone. We extended the evaluation of our new model to include six chemicals that inhibit enzymes involved in steroid biosynthesis: fadrozole, ketoconazole, propiconazole, prochloraz, fenarimol, and trilostane. In addition, for unexposed fathead minnows from group spawning design studies, and those exposed to the six chemicals, we evaluated whether the model is capable of predicting the average number of eggs per spawn and the average number of spawns per female, which was not evaluated previously. The new model is significantly improved in terms of ease of use, platform independence, and utility for providing output in a format that can be used as input into a population dynamics model. Model-predicted minimum and maximum cumulative fecundity over time encompassed the observed data for fadrozole and most propiconazole, prochloraz, fenarimol and trilostane treatments, but did not consistently replicate results fromketoconazole treatments. For average fecundity (eggs.female(-1).day(-1)), eggs per spawn, and the number of spawns per female, the range of model-predicted values generally encompassed the experimentally observed values. Overall, we found that the model predicts reproduction metrics robustly and its predictions capture the variability in the experimentally observed data.
C1 [Watanabe, Karen H.] Oregon Hlth & Sci Univ, Inst Environm Hlth, Div Environm & Biomol Syst, Portland, OR 97201 USA.
[Watanabe, Karen H.] Oregon Hlth & Sci Univ, Sch Publ Hlth, Portland, OR 97201 USA.
[Mayo, Michael; Perkins, Edward J.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA.
[Jensen, Kathleen M.; Villeneuve, Daniel L.; Ankley, Gerald T.] US EPA, Midcontinent Ecol Div, Duluth, MN USA.
RP Watanabe, KH (reprint author), Oregon Hlth & Sci Univ, Inst Environm Hlth, Div Environm & Biomol Syst, Portland, OR 97201 USA.
EM watanabk@ohsu.edu
FU US Army Environmental Quality and Installations 6.1 Basic Research
Program
FX US Army Environmental Quality and Installations 6.1 Basic Research
Program funding to KHW, MM, and EJP. United States Army Corps of
Engineers cooperative agreement to KHW (# W912HZ-11-2-0023). The funders
had no role in study design, data collection and analysis, decision to
publish, or preparation of the manuscript.
NR 38
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U1 1
U2 11
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 12
PY 2016
VL 11
IS 1
AR e0146594
DI 10.1371/journal.pone.0146594
PG 26
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DA6CG
UT WOS:000367888800017
PM 26756814
ER
PT J
AU Hu, Y
Shaw, AP
Guan, HR
Norton, JR
Sattler, W
Rong, Y
AF Hu, Yue
Shaw, Anthony P.
Guan, Hairong
Norton, Jack R.
Sattler, Wesley
Rong, Yi
TI Synthesis and Resolution of Chiral Ruthenium Complexes Containing the
1-Me-3-PhCp Ligand
SO ORGANOMETALLICS
LA English
DT Article
ID ASYMMETRIC TRANSFER HYDROGENATION; ARENE CHROMIUM COMPLEXES; C-H
FUNCTIONALIZATION; ENANTIOMERICALLY PURE; ABSOLUTE-CONFIGURATION;
CYCLOPENTADIENYLMETAL COMPLEXES; CRYSTALLOGRAPHIC DETERMINATION;
PALLADIUM COMPLEXES; CRYSTAL-STRUCTURES; ANCHOR PHOSPHINE
AB A new ruthenium chloride complex featuring chirality derived from the face-specific coordination of the 1-Me-3-PhCp ligand has been successfully synthesized and resolved. The resolution has been achieved via the diastereomers of the (5)-alpha-methylbenzenemethanethiolate complex (1-Me-3-PhCp)Ru(dppm){(S)-C(S)(H)(Ph)(Me)}. The X-ray structures of (S-Cp,S)-(1-Me-3-PhCp)Ru(dppm){C(S)(H)(Ph)(Me)} and (R-Cp,S)-(1-Me-3-PhCp)Ru(dppm){C(S)(H)(Ph)(Me)} have been determined. Racemization has been observed at elevated temperatures, but a room-temperature conversion pathway provides access to the corresponding enantiopure acetonitrile, chloride, and hydride complexes.
C1 [Hu, Yue] Eastman Chem Co, Kingsport, TN 37662 USA.
[Shaw, Anthony P.] US Army RDECOM ARDEC, Pyrotech Technol & Prototyping Div, Picatinny Arsenal, NJ 07806 USA.
[Guan, Hairong] Univ Cincinnati, Dept Chem, Cincinnati, OH 45221 USA.
[Norton, Jack R.; Rong, Yi] Columbia Univ, Dept Chem, New York, NY 10027 USA.
[Sattler, Wesley] Dow Chem Co USA, Dow Elect Mat, Marlborough, MA 01752 USA.
RP Norton, JR (reprint author), Columbia Univ, Dept Chem, New York, NY 10027 USA.
EM jrn11@columbia.edu
RI Guan, Hairong/I-1987-2013
OI Guan, Hairong/0000-0002-4858-3159
FU NSF [CHE-0749537]; Boulder Scientific; OFS Fitel
FX This research was supported by NSF grant CHE-0749537, Boulder
Scientific, and OFS Fitel. The National Science Foundation is thanked
for acquisition of an X-ray diffractometer (CHE-0619638) and a 400 MHz
NMR spectrometer (CHE-0840451). The authors are grateful to Prof. G.
Parkin (Columbia University) for assistance with the X-ray structure
determinations, and to Prof. J. Magyar (Barnard College) and Prof. J.
Canary (NYU) for access to their circular dichroism spectrometers.
NR 92
TC 0
Z9 0
U1 6
U2 19
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0276-7333
EI 1520-6041
J9 ORGANOMETALLICS
JI Organometallics
PD JAN 11
PY 2016
VL 35
IS 1
BP 39
EP 46
DI 10.1021/acs.organomet.5b00852
PG 8
WC Chemistry, Inorganic & Nuclear; Chemistry, Organic
SC Chemistry
GA DA8IJ
UT WOS:000368048000008
ER
PT J
AU Madan, RA
Donahue, RN
Singh, H
Karzai, F
Theoret, MR
Heery, CR
Strauss, J
Harold, N
Couvillon, A
Marte, JL
Hankin, A
Grenga, I
Chun, G
Rosner, IL
McLeod, DG
Cordes, LM
Figg, WD
Dahut, WL
Schlom, J
Gulley, JL
AF Madan, Ravi Amrit
Donahue, Renee Nicole
Singh, Harpreet
Karzai, Fatima
Theoret, Marc Robert
Heery, Christopher Ryan
Strauss, Julius
Harold, Nancy
Couvillon, Anna
Marte, Jennifer L.
Hankin, Amy
Grenga, Italia
Chun, Guinevere
Rosner, Inger L.
McLeod, David G.
Cordes, Lisa M.
Figg, William Douglas
Dahut, William L.
Schlom, Jeffrey
Gulley, James L.
TI Clinical and immunologic impact of short course enzalutamide without
androgen deprivation therapy for biochemically recurrent prostate
cancer.
SO JOURNAL OF CLINICAL ONCOLOGY
LA English
DT Meeting Abstract
CT Genitourinary Cancers Symposium
CY JAN 07-09, 2016
CL San Francisco, CA
C1 NCI, NIH, Bethesda, MD 20892 USA.
Ctr Canc Res, Lab Tumor Immunol & Biol, Bethesda, MD USA.
NCI, Genitourinary Malignancies Branch, NIH, Bethesda, MD 20892 USA.
NCI, Genitourinary Malignancies Branch, CCR, NIH, Bethesda, MD 20892 USA.
NCI, Bethesda, MD 20892 USA.
Walter Reed Natl Mil Med Ctr, Bethesda, MD USA.
Walter Reed Army Med Ctr, Washington, DC 20307 USA.
NIH, Bldg 10, Bethesda, MD 20892 USA.
NCI, Clin Pharmacol Program, NIH, Bethesda, MD 20892 USA.
NCI, Lab Tumor Immunol & Biol, NIH, Bethesda, MD 20892 USA.
RI Gulley, James/K-4139-2016; Figg Sr, William/M-2411-2016
OI Gulley, James/0000-0002-6569-2912;
NR 0
TC 1
Z9 1
U1 0
U2 0
PU AMER SOC CLINICAL ONCOLOGY
PI ALEXANDRIA
PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA
SN 0732-183X
EI 1527-7755
J9 J CLIN ONCOL
JI J. Clin. Oncol.
PD JAN 10
PY 2016
VL 34
IS 2
SU S
MA 214
PG 1
WC Oncology
SC Oncology
GA DO9LW
UT WOS:000378109100214
ER
PT J
AU Spring, MD
Pichyangkul, S
Lon, C
Gosi, P
Yongvanichit, K
Srichairatanakul, U
Limsalakpeth, A
Chaisatit, C
Chann, S
Sriwichai, S
Auayapon, M
Chaorattanakawee, S
Dutta, S
Prom, S
Chour, CM
Walsh, DS
Angov, E
Saunders, DL
AF Spring, Michele D.
Pichyangkul, Sathit
Lon, Chanthap
Gosi, Panita
Yongvanichit, Kosol
Srichairatanakul, Utaiwan
Limsalakpeth, Amporn
Chaisatit, Chaiyaporn
Chann, Soklyda
Sriwichai, Sabaithip
Auayapon, Montida
Chaorattanakawee, Suwanna
Dutta, Sheetij
Prom, Satharath
Chour, Char Meng
Walsh, Douglas S.
Angov, Evelina
Saunders, David L.
TI Antibody profiles to plasmodium merozoite surface protein-1 in Cambodian
adults during an active surveillance cohort with nested treatment study
SO MALARIA JOURNAL
LA English
DT Article
DE Malaria; Antibodies; Merozoite surface protein 1; Biomarker;
Chemoprophylaxis
ID VACCINE CANDIDATE ANTIGEN; CLINICAL MALARIA; FALCIPARUM MALARIA;
IMMUNE-RESPONSE; VIVAX RELAPSE; DOUBLE-BLIND; PROPHYLAXIS; MEFLOQUINE;
TAFENOQUINE; PROTECTION
AB Background: In addition to evidence for a protective role of antibodies to the malaria blood stage antigen merozoite surface protein 1 (MSP1), MSP1 antibodies are also considered as a marker of past malaria exposure in sero-epidemiological studies.
Methods: In order to better assess the potential use of MSP1 serology in malaria chemoprophylaxis trials in endemic areas, an analysis for the prevalence of antibodies to both Plasmodium falciparum and Plasmodium vivax MSP1(42) in healthy Cambodian adults was conducted at two sites as part of an active, observational cohort evaluating the efficacy of dihydroartemisinin-piperaquine (DP) for uncomplicated malaria (ClinicalTrials.gov identifier NCT01280162).
Results: Rates of baseline sero-positivity were high (59 and 73 % for PfMSP1(42) and PvMSP1(42), respectively), and titers higher in those who lived in a higher transmission area, although there was little correlation in titers between the two species. Those volunteers who subsequently went on to develop malaria had higher baseline MSP1(42) titers than those who did not for both species. Titers to both antigens remained largely stable over the course of the 4-6 month study, except in those infected with P. falciparum who had multiple recurrences.
Conclusion: These findings illuminate the difficulties in using MSP1(42) serology as either a screening criterion and/or biomarker of exposure in chemoprophylaxis studies. Further work remains to identify useful markers of malarial infection and/or immunity.
C1 [Spring, Michele D.; Pichyangkul, Sathit; Lon, Chanthap; Gosi, Panita; Yongvanichit, Kosol; Srichairatanakul, Utaiwan; Limsalakpeth, Amporn; Chaisatit, Chaiyaporn; Chann, Soklyda; Sriwichai, Sabaithip; Chaorattanakawee, Suwanna; Saunders, David L.] AFRIMS, Bangkok, Thailand.
[Auayapon, Montida] Ctr Excellence Biomed & Publ Hlth Informat BIOPHI, Bangkok, Thailand.
[Dutta, Sheetij; Angov, Evelina] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Prom, Satharath] Royal Cambodian Armed Forces, Phnom Penh, Cambodia.
[Chour, Char Meng] Natl Ctr Parasitol Entomol & Malaria Control CNM, Phnom Penh, Cambodia.
[Walsh, Douglas S.] SUNY Upstate Med Univ, Syracuse, NY 13210 USA.
RP Lon, C (reprint author), AFRIMS, Bangkok, Thailand.
EM chanthapl@afrims.org
NR 40
TC 0
Z9 0
U1 0
U2 1
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2875
J9 MALARIA J
JI Malar. J.
PD JAN 8
PY 2016
VL 15
AR 17
DI 10.1186/s12936-015-1058-8
PG 10
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA DB3FW
UT WOS:000368396700001
PM 26747132
ER
PT J
AU Borodin, O
Olguin, M
Ganesh, P
Kent, PRC
Allen, JL
Henderson, WA
AF Borodin, Oleg
Olguin, Marco
Ganesh, P.
Kent, Paul R. C.
Allen, Joshua L.
Henderson, Wesley A.
TI Competitive lithium solvation of linear and cyclic carbonates from
quantum chemistry
SO PHYSICAL CHEMISTRY CHEMICAL PHYSICS
LA English
DT Article
ID LI-ION BATTERY; MOLECULAR-DYNAMICS SIMULATIONS; ORGANIC
ELECTROLYTE-SOLUTIONS; POLARIZABLE FORCE-FIELDS; PC-EC SOLUTIONS;
ETHYLENE CARBONATE; PROPYLENE CARBONATE; TRANSPORT-PROPERTIES;
AB-INITIO; COMPUTATIONAL/SPECTROSCOPIC CHARACTERIZATION
AB The composition of the lithium cation (Li+) solvation shell in mixed linear and cyclic carbonate-based electrolytes has been re-examined using Born Oppenheimer molecular dynamics (BOMD) as a function of salt concentration and cluster calculations with ethylene carbonate:dimethyl carbonate (EC:DMC)-LiPF6 as a model system. A coordination preference for EC over DMC to a Li+ was found at low salt concentrations, while a slightly higher preference for DMC over EC was found at high salt concentrations. Analysis of the relative binding energies of the (EC)(n)(DMC)(m) Li+ and (EC)(n)(DMC)(m)-LiPF6 solvates in the gas-phase and for an implicit solvent (as a function of the solvent dielectric constant) indicated that the DMC-containing Li+ solvates were stabilized relative to (EC4)-Li+ and (EC)(3)-LiPF6 by immersing them in the implicit solvent. Such stabilization was more pronounced in the implicit solvents with a high dielectric constant. Results from previous Raman and IR experiments were reanalyzed and reconciled by correcting them for changes of the Raman activities, IR intensities and band shifts for the solvents which occur upon Li+ coordination. After these correction factors were applied to the results of BOMD simulations, the composition of the Li+ solvation shell from the BOMD simulations was found to agree well with the solvation numbers extracted from Raman experiments. Finally, the mechanism of the Li+ diffusion in the dilute (EC:DMC)LiPF6 mixed solvent electrolyte was studied using the BOMD simulations.
C1 [Borodin, Oleg; Olguin, Marco; Allen, Joshua L.] US Army, Electrochem Branch, RDRL SED C, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
[Ganesh, P.; Kent, Paul R. C.] Oak Ridge Natl Lab, Ctr Nanophase Mat Sci, 1 Bethel Valley Rd, Oak Ridge, TN 37831 USA.
[Kent, Paul R. C.] Oak Ridge Natl Lab, Div Math & Comp Sci, 1 Bethel Valley Rd, Oak Ridge, TN 37831 USA.
[Henderson, Wesley A.] Pacific NW Natl Lab, Electrochem Mat & Syst Grp, Energy & Environm Directorate, Richland, WA 99352 USA.
RP Borodin, O (reprint author), US Army, Electrochem Branch, RDRL SED C, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM oleg.a.borodin.civ@mail.mil; ganeshp@ornl.gov
RI Kent, Paul/A-6756-2008;
OI Kent, Paul/0000-0001-5539-4017; Ganesh,
Panchapakesan/0000-0002-7170-2902
FU Oak Ridge Associated Universities (ORAU) Postdoctoral Fellowship; Office
of Science of the U.S. Department of Energy [DE-AC05-00OR22725]; U.S.
Department of Energy, Office of Science, Office of Basic Energy Sciences
FX We thank Rang Xu and Arthur von Cresce for very stimulating discussions.
QC calculations of solvates in implicit solvent and BOMD simulations of
electrolytes were supported by the ARL Enterprise for Multiscale
Research. M. O. was supported by an Oak Ridge Associated Universities
(ORAU) Postdoctoral Fellowship. This research used resources of the Oak
Ridge Leadership Computing Facility at the Oak Ridge National
Laboratory, which is supported by the Office of Science of the U.S.
Department of Energy under Contract No. DE-AC05-00OR22725. Plane wave
calculations using VASP were supported as part of the Fluid Interface
Reactions, Structures and Transport (FIRST) Center, an Energy Frontier
Research Center funded by the U.S. Department of Energy, Office of
Science, Office of Basic Energy Sciences.
NR 87
TC 11
Z9 11
U1 13
U2 38
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 1463-9076
EI 1463-9084
J9 PHYS CHEM CHEM PHYS
JI Phys. Chem. Chem. Phys.
PD JAN 7
PY 2016
VL 18
IS 1
BP 164
EP 175
DI 10.1039/c5cp05121e
PG 12
WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical
SC Chemistry; Physics
GA DB8GP
UT WOS:000368755500017
PM 26601903
ER
PT J
AU Lesch, V
Li, Z
Bedrov, D
Borodin, O
Heuer, A
AF Lesch, Volker
Li, Zhe
Bedrov, Dmitry
Borodin, Oleg
Heuer, Andreas
TI The influence of cations on lithium ion coordination and transport in
ionic liquid electrolytes: a MD simulation study
SO PHYSICAL CHEMISTRY CHEMICAL PHYSICS
LA English
DT Article
ID MOLECULAR-DYNAMICS SIMULATION; POLARIZABLE FORCE-FIELD;
N-PROPYLPYRROLIDINIUM BIS(TRIFLUOROMETHANESULFONYL)IMIDE; SALT MIXTURES;
PHYSICOCHEMICAL PROPERTIES; PYRROLIDINIUM CATIONS; POLYMER ELECTROLYTES;
LIX MIXTURES; DOUBLE-LAYER; TFSI-ANIONS
AB The dynamical and structural properties in two ionic liquid electrolytes (ILEs) based on 1-ethyl-3-methylimidazolium bis-(trifluoromethanesulfonyl)-imide ([emim][TFSI]) and N-methyl-N-propylpyrrolidinium bis-(trifluoromethanesulfonyl)imide([pyr(13)][TFSI]) were compared as a function of lithium bis(trifluoromethanesulfonyl)-imide (LiTFSI) salt concentrations using atomistic molecular dynamics (MD) simulations. The many-body polarizable APPLE&P force field has been utilized. The influence of anion polarization on the structure of the first coordination shell of Li+ was examined. In particular, the reduction of the oxygen of the TFSI anion (O-TFSI) polarizability from 1.36 angstrom(3) to 1.00 angstrom(3) resulted in an increased fraction of the TFSI anion bidentate coordination to the Li+. While the overall dynamics in [pyr(13)][TFSI]-based ILEs was slower than in [emim][TFSI]-based ILEs, the exchange of TFSI anions in and out of the first coordination shell of Li+ was found to be faster in pyr(13)-based systems. The Li+ ion transference number is higher for these systems as well. These trends can be related to the difference in interaction of TFSI with the IL cation which is stronger for pyr(13) than for emim.
C1 [Lesch, Volker] Forschungszentrum Julich, Helmholtz Inst Munster, Inst Energie & Klimaforsch, Ion Energy Storage, Corrensstr 46, D-48149 Munster, Germany.
[Lesch, Volker; Heuer, Andreas] Univ Munster, Inst Phys Chem, Corrensstr 28-30, D-48149 Munster, Germany.
[Li, Zhe; Bedrov, Dmitry] Univ Utah, Dept Mat Sci & Engn, 122 South Cent Campus Dr,Room 304, Salt Lake City, UT 84112 USA.
[Borodin, Oleg] US Army Res Lab, Electrochem Branch, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
RP Lesch, V (reprint author), Forschungszentrum Julich, Helmholtz Inst Munster, Inst Energie & Klimaforsch, Ion Energy Storage, Corrensstr 46, D-48149 Munster, Germany.; Lesch, V (reprint author), Univ Munster, Inst Phys Chem, Corrensstr 28-30, D-48149 Munster, Germany.
EM v.lesch@fr-juelich.de
FU federal ministry of research and education [03X4631N]; Army Research
Laboratory [W911NF-12-2-0023]
FX We greatly acknowledge helpful discussions with Jens Smiatek, Christian
Schroder, Jose Nuno Canongia Lopes and Diddo Diddens. V. L. and A. H.
thank the federal ministry of research and education (Forderkennzeichen:
03X4631N) for financial support. D. B. and O. B. gratefully acknowledge
the support from project sponsored by Army Research Laboratory under
Cooperative Agreement Number W911NF-12-2-0023. The views and conclusions
contained in this document are those of the authors and should not be
interpreted as representing the official policies, either expressed or
implied, of ARL or the U.S. Government. The U.S. Government is
authorized to reproduce and distribute reprints for Government purposes
notwithstanding any copyright notation herein.
NR 94
TC 6
Z9 6
U1 6
U2 31
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 1463-9076
EI 1463-9084
J9 PHYS CHEM CHEM PHYS
JI Phys. Chem. Chem. Phys.
PD JAN 7
PY 2016
VL 18
IS 1
BP 382
EP 392
DI 10.1039/c5cp05111h
PG 11
WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical
SC Chemistry; Physics
GA DB8GP
UT WOS:000368755500042
PM 26617256
ER
PT J
AU He, YD
Qiao, R
Vatamanu, J
Borodin, O
Bedrov, D
Huang, JS
Sumpter, BG
AF He, Yadong
Qiao, Rui
Vatamanu, Jenel
Borodin, Oleg
Bedrov, Dmitry
Huang, Jingsong
Sumpter, Bobby G.
TI Importance of Ion Packing on the Dynamics of Ionic Liquids during
Micropore Charging
SO JOURNAL OF PHYSICAL CHEMISTRY LETTERS
LA English
DT Article
ID SUBNANOMETER PORES; FILLED NANOPORES; SLIT NANOPORE; CAPACITANCE;
CARBON; SUPERCAPACITORS; SIMULATIONS; SIZE; ELECTRODES; STORAGE
AB Molecular simulations of the diffusion of EMIM+ and TESI- ions in slit-shaped micropores under conditions similar to those during charging show that in pores that accommodate only a single layer of ions, ions diffuse increasingly faster as the pore becomes charged (with diffusion coefficients even reaching similar to 5 x 10(-9) m(2)/s), unless the pore becomes very highly charged. In pores wide enough to fit more than one layer of ions, ion diffusion is slower than in the bulk and changes modestly as the pore becomes charged. Analysis of these results revealed that the fast (or slow) diffusion of ions inside a micropore during charging is correlated most strongly with the dense (or loose) ion packing inside the pore. The molecular details of the ions and the precise width of the pores modify these trends weakly, except when the pore is so narrow that the ion conformation relaxation is strongly constrained by the pore walls.
C1 [He, Yadong; Qiao, Rui] Virginia Tech, Dept Mech Engn, Blacksburg, VA 24061 USA.
[Borodin, Oleg] US Army, Electrochem Branch, Res Lab, Adelphi, MD 20783 USA.
[Vatamanu, Jenel; Bedrov, Dmitry] Univ Utah, Dept Mat Sci & Engn, Salt Lake City, UT 84112 USA.
[Huang, Jingsong; Sumpter, Bobby G.] Oak Ridge Natl Lab, Ctr Nanophase Mat Sci, Oak Ridge, TN 37831 USA.
[Huang, Jingsong; Sumpter, Bobby G.] Oak Ridge Natl Lab, Comp Sci & Math Div, Oak Ridge, TN 37831 USA.
RP Qiao, R (reprint author), Virginia Tech, Dept Mech Engn, Blacksburg, VA 24061 USA.
EM ruiqiao@vt.edu
RI Sumpter, Bobby/C-9459-2013; Huang, Jingsong/A-2789-2008; Vatamanu,
Jenel/I-7638-2012; Qiao, Rui/B-2350-2009
OI Sumpter, Bobby/0000-0001-6341-0355; Huang, Jingsong/0000-0001-8993-2506;
Vatamanu, Jenel/0000-0003-0825-1608; Qiao, Rui/0000-0001-5219-5530
FU NSF [CBET-1461842]; University of Utah MRSEC (NSF grant) [DMR 11-21252]
FX We thank the Clemson-CCIT and ARC at Virginia Tech for generous
allocations of computer time on the Palmetto cluster and BlueRidge
cluster. R.Q, acknowledges the support from NSF (CBET-1461842). R.Q, was
partially supported by an appointment to the HERE program for faculty at
the Oak Ridge National Laboratory (ORNL) administered by ORISE. D.B. and
J.V. acknowledge the University of Utah MRSEC (NSF grant no. DMR
11-21252) for the support through the seed grant program. J.H. and
B.G.S. acknowledge work performed at the Center for Nanophase Materials
Sciences, a U.S. DOE Office of Science User Facility.
NR 46
TC 8
Z9 8
U1 6
U2 26
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1948-7185
J9 J PHYS CHEM LETT
JI J. Phys. Chem. Lett.
PD JAN 7
PY 2016
VL 7
IS 1
BP 36
EP 42
DI 10.1021/acs.jpclett.5b02378
PG 7
WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science,
Multidisciplinary; Physics, Atomic, Molecular & Chemical
SC Chemistry; Science & Technology - Other Topics; Materials Science;
Physics
GA DA7EZ
UT WOS:000367968700007
PM 26641287
ER
PT J
AU Faria, M
Garcia-Reyero, N
Padros, F
Babin, PJ
Sebastian, D
Cachot, J
Prats, E
Arick, M
Rial, E
Knoll-Gellida, A
Mathieu, G
Le Bihanic, F
Escalon, BL
Zorzano, A
Soares, AMVM
Raldua, D
AF Faria, Melissa
Garcia-Reyero, Natalia
Padros, Francesc
Babin, Patrick J.
Sebastian, David
Cachot, Jerome
Prats, Eva
Arick, Mark, II
Rial, Eduardo
Knoll-Gellida, Anja
Mathieu, Guilaine
Le Bihanic, Florane
Escalon, B. Lynn
Zorzano, Antonio
Soares, Amadeu M. V. M.
Raldua, Demetrio
TI Zebrafish Models for Human Acute Organophosphorus Poisoning (vol 5,
15591, 2015)
SO SCIENTIFIC REPORTS
LA English
DT Correction
C1 [Arick, Mark, II] Mississippi State Univ, IGBB, Starkville, MS USA.
[Escalon, B. Lynn] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA.
RI Soares, Amadeu/A-8304-2008
OI Soares, Amadeu/0000-0003-0879-9470
NR 1
TC 0
Z9 0
U1 1
U2 6
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JAN 7
PY 2016
VL 6
AR 17244
DI 10.1038/srep17244
PG 1
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DA9ZN
UT WOS:000368168400002
PM 26738741
ER
PT J
AU Bates, ME
Grieger, KD
Trump, BD
Keisler, JM
Plourde, KJ
Linkov, I
AF Bates, Matthew E.
Grieger, Khara D.
Trump, Benjamin D.
Keisler, Jeffrey M.
Plourde, Kenton J.
Linkov, Igor
TI Emerging Technologies for Environmental Remediation: Integrating Data
and Judgment
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID MULTICRITERIA DECISION-ANALYSIS; SYNTHETIC-BIOLOGY; RISK-ASSESSMENT;
NANOMATERIALS; NZVI
AB Emerging technologies present significant challenges to researchers, decision-makers, industry professionals, and other stakeholder groups due to the lack of quantitative risk, benefit, and cost data associated with their use. Multi-criteria decision analysis (MCDA) can support early decisions for emerging technologies when data is too sparse or uncertain for traditional risk assessment. It does this by integrating expert judgment with available quantitative and qualitative inputs across multiple criteria to provide relative technology scores. Here, an MCDA framework provides preliminary insights on the suitability of emerging technologies for environmental remediation by comparing nanotechnology and synthetic biology to conventional remediation methods. Subject matter experts provided judgments regarding the importance of criteria used in the evaluations and scored the technologies with respect to those criteria. The results indicate that synthetic biology may be preferred over nanotechnology and conventional methods for high expected benefits and low deployment costs but that conventional technology may be preferred over emerging technologies for reduced risks and development costs. In the absence of field data regarding the risks, benefits, and costs of emerging technologies, structuring evidence-based expert judgment through a weighted hierarchy of topical questions may be helpful to inform preliminary risk governance and guide emerging technology development and policy.
C1 [Bates, Matthew E.; Linkov, Igor] US Army Corps Engineers, Engn Res & Dev Ctr, Environm Lab, Concord, MA 01742 USA.
[Grieger, Khara D.] RTI Int, Res Triangle Pk, NC 27709 USA.
[Trump, Benjamin D.] Univ Michigan, Sch Publ Hlth, Ann Arbor, MI 48109 USA.
[Keisler, Jeffrey M.] Univ Massachusetts, Coll Management, Boston, MA 02125 USA.
[Plourde, Kenton J.] US Army Corps Engineers, SOL Engn Serv, Concord, MA 01742 USA.
RP Bates, ME (reprint author), US Army Corps Engineers, Engn Res & Dev Ctr, Environm Lab, 696 Virginia Rd, Concord, MA 01742 USA.
EM Matthew.E.Bates@usace.army.mil; Igor.Linkov@usace.army.mil
FU Engineer Research and Development Center of the U.S. Army Corps of
Engineers; RTI International
FX This study was funded by the Engineer Research and Development Center of
the U.S. Army Corps of Engineers and by RTI International. It has been
approved for publication by authority of the Chief of Engineers, U.S.
Army Corps of Engineers.
NR 34
TC 4
Z9 4
U1 5
U2 24
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD JAN 5
PY 2016
VL 50
IS 1
BP 349
EP 358
DI 10.1021/acs.est.5b03005
PG 10
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA DA5TU
UT WOS:000367866300040
PM 26580228
ER
PT J
AU Naluyima, P
Eller, LA
Ouma, BJ
Kyabaggu, D
Kataaha, P
Guwatudde, D
Kibuuka, H
Wabwire-Mangen, F
Robb, ML
Michael, NL
de Souza, MS
Sandberg, JK
Eller, MA
AF Naluyima, Prossy
Eller, Leigh Anne
Ouma, Benson J.
Kyabaggu, Denis
Kataaha, Peter
Guwatudde, David
Kibuuka, Hannah
Wabwire-Mangen, Fred
Robb, Merlin L.
Michael, Nelson L.
de Souza, Mark S.
Sandberg, Johan K.
Eller, Michael A.
TI Sex and Urbanicity Contribute to Variation in Lymphocyte Distribution
across Ugandan Populations
SO PLOS ONE
LA English
DT Article
ID REFERENCE INTERVALS; IMMUNE-RESPONSES; HEALTHY UGANDANS; REFERENCE
VALUES; REFERENCE RANGES; VACCINE; TRIALS; ADULTS; EOSINOPHILS;
INFECTION
AB Management of patient care and interpretation of research data require evaluation of laboratory results in the context of reference data from populations with known health status to adequately diagnose disease or make a physiological assessment. Few studies have addressed the diversity of lymphocyte subsets in rural and urban Ugandan populations. Here, 663 healthy blood bank donors from semi-urban centers of Kampala consented to participate in a study to define lymphocyte reference ranges. Whole blood immunophenotyping was performed to determine the frequency and absolute counts of T, B, and NK cells using clinical flow cytometry. Results from blood bank donors were compared to a rural cohort from the district of Kayunga and more urban clinical trial participants from the capital city, Kampala. Relationships between hematological and lymphocyte parameters were also explored. In the semi-urban blood donors, females were significantly different from males in all parameters except the frequency of CD8 T and B cells. Females had higher absolute counts of CD4 T, CD8 T and B cells, whereas males had higher NK cell counts. NK cell frequency and counts were significantly higher in semi-urban blood donors, regardless of sex, compared to more urban study participants. CD8 T cell frequency and counts were significantly higher in the blood donors compared to the rural participants, irrespective of sex. Interestingly, basophil counts were positively associated with overall T cell counts. These findings suggest that both sex and level of cohort urbanicity may influence lymphocyte subset distributions in Ugandans.
C1 [Naluyima, Prossy; Ouma, Benson J.; Kyabaggu, Denis; Kibuuka, Hannah; Wabwire-Mangen, Fred] Makerere Univ, Walter Reed Project, Kampala, Uganda.
[Naluyima, Prossy; Sandberg, Johan K.] Karolinska Univ, Huddinge Hosp, Karolinska Inst, Ctr Infect Med,Dept Med, Stockholm, Sweden.
[Eller, Leigh Anne; Robb, Merlin L.; Michael, Nelson L.; Eller, Michael A.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 21218 USA.
[Eller, Leigh Anne; Robb, Merlin L.; Eller, Michael A.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
[Kataaha, Peter] Uganda Natl Blood Transfus Serv, Kampala, Uganda.
[Guwatudde, David; Wabwire-Mangen, Fred] Makerere Univ, Sch Publ Hlth, Coll Hlth Sci, Kampala, Uganda.
[de Souza, Mark S.] Thai Red Cross AIDS Res Ctr, SEARCH, Bangkok, Thailand.
RP Eller, MA (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 21218 USA.
EM meller@hivresearch.org
OI Sandberg, Johan/0000-0002-6275-0750
FU Henry M. Jackson Foundation for the Advancement of Military Medicine,
Inc. [W81XWH-11-2-0174]; U.S. Department of Defense (DoD)
[W81XWH-11-2-0174]; Swedish Research Council; Swedish Cancer Society;
Stockholm County Council; Karolinska Institutet; Division of Intramural
Research, NIAID, NIH
FX This work was supported by a cooperative agreement (W81XWH-11-2-0174)
between the Henry M. Jackson Foundation for the Advancement of Military
Medicine, Inc., and the U.S. Department of Defense (DoD). Additional
support was provided by the Swedish Research Council, the Swedish Cancer
Society, the Stockholm County Council, Karolinska Institutet, and the
Division of Intramural Research, NIAID, NIH.
NR 42
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PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 5
PY 2016
VL 11
IS 1
AR e0146196
DI 10.1371/journal.pone.0146196
PG 16
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DA4VZ
UT WOS:000367801400114
PM 26730706
ER
PT J
AU Crawford, P
Thai, C
Obholz, J
Schievenin, J
True, M
Shah, SA
Hallgren, J
Clark, J
Sharon, D
AF Crawford, Paul
Thai, Chuong
Obholz, Joshua
Schievenin, Jeffrey
True, Mark
Shah, Sachin A.
Hallgren, John
Clark, Jill
Sharon, Danny
TI Assessment of the effeCt of lIfestyle iNtervention plus water-soluble
ciNnAMon extract On loweriNg blood glucose in pre-diabetics, a
randomized, double-blind, multicenter, placebo controlled trial: study
protocol for a randomized controlled trial
SO TRIALS
LA English
DT Article
DE Diabetes; Cinnamon; Prevention; Pre-diabetes; Protocol; Cinnulin PF;
Cinnamon extract; Impaired glucose tolerance
ID ALTERNATIVE MEDICINE; TYPE-2; COMPLEMENTARY; MELLITUS; A1C; PEOPLE;
LIPIDS
AB Background: The World Health Organization predicts that by 2030 diabetes will be the seventh leading cause of death in the world. Multiple studies have tried to determine if cinnamon is an effective treatment for diabetes. Cinnamon extract is an insulin sensitizer, protects mesangial cells, decreases inflammatory markers, and lowers glucose, lipids, and blood pressure in patients with type 2 diabetes, so we developed a protocol to study whether ingestion of water-soluble cinnamon extract prevents progression from pre-diabetes to diabetes.
Methods/design: This is a randomized, double-blind, placebo-controlled trial comparing cinnamon extract versus placebo in subjects with pre-diabetes who have committed to participate in a lifestyle change program. The trial will be conducted at five sites and will include 428 subjects who take cinnamon extract or placebo for 1 year. Follow-up for these subjects will be for a total of 2 years (nine study visits). The primary outcomes to be assessed are 1) conversion of patients from pre-diabetes to diabetes and 2) impact of water-soluble cinnamon extract on hepatic transaminases, renal function, and QT interval on electrocardiogram. Secondary outcomes include changes in HbA1c, lipids, waist circumference, weight, blood pressure, and fasting plasma glucose. The trial protocol has been approved by the Institutional Review Board of the US Air Force 59th Medical Wing, Wilford Hall Ambulatory Surgical Center (Protocol FWH20110035H). Investigator-sponsored Investigational New Drug status (114078) was granted by the US Food and Drug Administration.
Discussion: This study will provide high-quality evidence of the efficacy of water-soluble cinnamon extract in conjunction with lifestyle intervention for preventing patients with pre-diabetes from converting to diabetes. Additionally, it will provide important safety information about water-soluble cinnamon extract.
C1 [Crawford, Paul] Nellis Family Med Residency, Las Vegas, NV 89191 USA.
[Thai, Chuong; Obholz, Joshua; Schievenin, Jeffrey] Eglin AFB Family Med Residency, Eglin AFB, FL 32542 USA.
[True, Mark] Brooke Army Med Ctr, Air Force Endocrinol Fellowship, Jbsa Ft Sam Houston, TX 78234 USA.
[Shah, Sachin A.] Univ Pacific, Pharm Practice, Vacaville, CA USA.
[Hallgren, John] 55MDOS, Offutt AFB, NE 68113 USA.
[Clark, Jill] Nellis Clin Invest Program, Las Vegas, NV 89191 USA.
[Sharon, Danny] Adolos Strateg, San Antonio, TX USA.
RP Crawford, P (reprint author), Nellis Family Med Residency, 4700 Las Vegas Blvd N, Las Vegas, NV 89191 USA.
EM paul.crawford@us.af.mil
FU US Air Force Medical Support Agency (AFMSA) SG9 Operational Medicine
Branch, Fuchsia Program Diabetes Funding program; US Air Force 59th
Medical Wing Science and Technology Section; 99th Medical Group;
Integrity Nutraceuticals (Spring Hill, TN)
FX Funding for this trial was provided 1) by US Air Force Medical Support
Agency (AFMSA) SG9 Operational Medicine Branch, Fuchsia Program Diabetes
Funding program in 2011; 2) by the US Air Force 59th Medical Wing
Science and Technology Section in 2014; 3) through a Cooperative
Research and Development Agreement between the 99th Medical Group and
Integrity Nutraceuticals (Spring Hill, TN) whereby Integrity provided
Cinnulin PF and placebo for free; and 4) through intramural support from
each participating hospital.
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PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1745-6215
J9 TRIALS
JI Trials
PD JAN 5
PY 2016
VL 17
AR 9
DI 10.1186/s13063-015-1138-7
PG 6
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA DA4UJ
UT WOS:000367796400005
PM 26732017
ER
PT J
AU Henry, NC
Brown, A
Knorr, DB
Baril, N
Nallon, E
Lenhart, JL
Tidrow, M
Bandara, S
AF Henry, Nathan C.
Brown, Alexander
Knorr, Daniel B.
Baril, Neil
Nallon, Eric
Lenhart, Joseph L.
Tidrow, Meimei
Bandara, Sumith
TI Surface conductivity of InAs/GaSb superlattice infrared detectors
treated with thiolated self assembled monolayers
SO APPLIED PHYSICS LETTERS
LA English
DT Article
ID MOBILITY-SPECTRUM ANALYSIS; INAS SURFACES; ACCUMULATION; PASSIVATION;
WAVELENGTH
AB The surface conductivity of InAs/GaSb based type II superlattice (T2SL) long wavelength infrared material following the deposition of thiolated self-assembled monolayers (SAMs) of cysteamine, octadecanethiol, dodecanethiol, and hexanethiol are reported. Quantitative mobility spectrum analysis (QMSA) was employed to study the mobility and to isolate and identify surface carriers following SAM treatments on planar samples. QMSA data collected following the deposition of the SAMs on InAs/GaSb material correlates well with dark current measurements, demonstrating the usefulness of QMSA as a tool for evaluating surface conductivity and predicting device performance. All samples displayed a reduction in surface conductivity and dark current density following thiol treatment. Dark current densities were reduced to 1.1 x 10(-5), 1.3 x 10(-5), 1.6 x 10(-5), and 5 x 10(-6) A/cm(2) for hexanethiol, dodecanethiol, octadecanethiol, and cysteamine, respectively, from 5.7 x 10(-4) A cm(2) for unpassivated devices. (C) 2016 AIP Publishing LLC.
C1 [Henry, Nathan C.; Brown, Alexander] Fulcrum Co, Centreville, VA 20120 USA.
[Henry, Nathan C.; Brown, Alexander; Baril, Neil; Nallon, Eric; Tidrow, Meimei; Bandara, Sumith] US Army, RDECOM CERDEC NVESD, Ft Belvoir, VA 22060 USA.
[Knorr, Daniel B.; Lenhart, Joseph L.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Henry, NC (reprint author), US Army, RDECOM CERDEC NVESD, Ft Belvoir, VA 22060 USA.; Henry, NC (reprint author), 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA.
EM info@nvl.army.mil
OI Henry, Nathan/0000-0002-7033-8467
NR 23
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U1 5
U2 11
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0003-6951
EI 1077-3118
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD JAN 4
PY 2016
VL 108
IS 1
AR 011606
DI 10.1063/1.4938168
PG 4
WC Physics, Applied
SC Physics
GA DJ6HU
UT WOS:000374313000018
ER
PT J
AU Modjarrad, K
Giersing, B
Kaslow, DC
Smith, PG
Moorthy, VS
AF Modjarrad, Kayvon
Giersing, Birgitte
Kaslow, David C.
Smith, Peter G.
Moorthy, Vasee S.
CA WHO RSV Vaccine Consultation
TI WHO consultation on Respiratory Syncytial Virus Vaccine Development
Report from a World Health Organization Meeting held on 23-24 March 2015
SO VACCINE
LA English
DT Article
DE Respiratory syncytial virus; Vaccine; Clinical development
ID NANOPARTICLE VACCINE; RSV VACCINE; INFECTION; INFANTS; CHILDREN;
IMMUNIZATION; DISEASE; LIVE; IMMUNOGENICITY; ANTIBODIES
AB Respiratory syncytial virus (RSV) is a globally prevalent cause of lower respiratory infection in neonates and infants. Despite its disease burden, a safe and effective RSV vaccine has remained elusive. In recent years, improved understanding of RSV biology and innovations in immunogen design has resulted in the advancement of multiple vaccine candidates into the clinical development pipeline. Given the growing number of vaccines in clinical trials, the rapid pace at which they are being tested, and the likelihood that an RSV vaccine will reach the commercial market in the next 5-10 years, consensus and guidance on clinical development pathways and licensure routes are needed now, before large-scale efficacy trials commence. In pursuit of this aim, the World Health Organization convened the first RSV vaccine consultation in 15 years on the 23rd and 24th of March, 2015 in Geneva, Switzerland. The meeting's primary objective was to provide guidance on clinical endpoints and development pathways for vaccine trials with a focus on considerations of low- and middle-income countries. Meeting participants reached consensus on candidate case definitions for RSV disease, considerations for clinical efficacy endpoints, and the clinical development pathway for active and passive immunization trials in maternal and pediatric populations. The strategic focus of this meeting was on the development of high quality, safe and efficacious RSV preventive interventions for global use and included; (1) maternal/passive immunization to prevent RSV disease in infants less than 6 months; (2) pediatric immunization to prevent RSV disease in infants and young children once protection afforded by maternal immunization wanes. (C) 2015 World Health Organization; licensee Elsevier. Published by Elsevier Ltd. All rights reserved.
C1 [Modjarrad, Kayvon; Giersing, Birgitte; Moorthy, Vasee S.] WHO, Initiat Vaccine Res, CH-1211 Geneva 27, Switzerland.
[Modjarrad, Kayvon] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA.
[Kaslow, David C.] PATH, Seattle, WA 98109 USA.
[Smith, Peter G.] Univ London London Sch Hyg & Trop Med, London WC1E 7HT, England.
RP Moorthy, VS (reprint author), WHO, Initiat Vaccine Res, CH-1211 Geneva 27, Switzerland.
EM moorthyv@who.int
RI Nair, Harish/E-7431-2010
OI Nair, Harish/0000-0002-9432-9100
FU Bill & Melinda Gates Foundation
FX We acknowledge the preparatory analysis of endpoints and case
definitions used in previous RSV preventive intervention trials
developed by Prof. Eric Simoes of the University of Colorado Health
Sciences Center, Denver, Colorado, USA. Fig. 1 is adapted from the PATH
RSV Vaccine Snapshot. We acknowledge the technical input into the
preparation for the consultation by the following individuals: Professor
Barney Graham of Vaccine Research Center, NIAID, Bethesda, MD, USA;
Professor Ruth Karron of Center for Immunization Research, Johns Hopkins
University, Baltimore, MD, USA and Dr Jeff Roberts, US Food and Drug
Administration, Center for Biologics Evaluation and Research, Silver
Spring, MD, USA. WHO's RSV vaccine acitivities are guided by a Technical
Advisory Group consisting of Prof. Narendra Arora, the INCLEN Trust
International, New Delhi, India; Dr Mair Powell, Medicines and
Healthcare Products Regulatory Agency, London, UK; Prof. Helen Rees,
Wits Reproductive Health and HIV Institute, Johannesburg, South Africa
and Prof. Peter Smith, London School of Hygiene and Tropical Medicine,
London, UK. We gratefully acknowledge funding from the Bill & Melinda
Gates Foundation to support the consultation reported here.
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PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
EI 1873-2518
J9 VACCINE
JI Vaccine
PD JAN 4
PY 2016
VL 34
IS 2
BP 190
EP 197
DI 10.1016/j.vaccine.2015.05.093
PG 8
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA DB0RD
UT WOS:000368214300002
PM 26100926
ER
PT J
AU Teegavarapu, RSV
Pathak, CS
Mecikalski, JR
Srikishen, J
AF Teegavarapu, Ramesh S. V.
Pathak, Chandra S.
Mecikalski, John R.
Srikishen, Jayanthi
TI Optimal solar radiation sensor network design using spatial and
geostatistical analyses
SO JOURNAL OF SPATIAL SCIENCE
LA English
DT Review
DE geostatistics; standard error; optimal sensor network; geospatial
analysis; evapotranspiration; solar radiation
ID SURFACE INSOLATION; SATELLITE DATA; POTENTIAL EVAPOTRANSPIRATION;
SAMPLING DESIGN; METEOSAT DATA; MODEL; IRRADIANCE; CLIMATOLOGY;
EVAPORATION; WATER
AB A methodology for optimal ground-based sensor network design for an evapotranspiration (ET) estimation method which uses solar radiation as the only parameter is developed and evaluated in this study. The methodology employs geospatial analyses and a geostatistical approach, and data from ground-based sensors and satellite-based estimates of solar insolation (i.e. total amount of solar radiation energy received on a given surface area during a given time) considering the spatial variability of the data. The applicability of the methodology is demonstrated by using Geostationary Operational Environmental Satellite (GOES)-estimated and 29 ground sensor-based observed solar insolation data in the South Florida region of the USA. Results indicate that the optimal design of network depends on the spatial variability of insolation, analysis block size defined based on region-specific radiation characteristics, and the standard error used as a metric of network estimation accuracy.
C1 [Teegavarapu, Ramesh S. V.] Florida Atlantic Univ, Dept Civil Engn, Boca Raton, FL 33431 USA.
[Pathak, Chandra S.] US Army, Corps Engineers, Hydrol Hydraul & Coastal Community Practice, Washington, DC 20310 USA.
[Mecikalski, John R.] Univ Alabama, Dept Atmospher Sci, 320 Sparkmen Dr, Huntsville, AL 35899 USA.
[Srikishen, Jayanthi] NASA, George C Marshall Space Flight Ctr, Univ Space Res Assoc, 320 Sparkman Dr, Huntsville, AL 35812 USA.
RP Teegavarapu, RSV (reprint author), Florida Atlantic Univ, Dept Civil Engn, Boca Raton, FL 33431 USA.
EM rteegava@fau.edu
FU South Florida Water Management District (SFWMD), Florida, USA
FX The authors sincerely thank the three anonymous reviewers and the
associate editor for providing several constructive comments that have
led to substantial improvement of the manuscript. The study reported in
the paper was supported by South Florida Water Management District
(SFWMD), Florida, USA.
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PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1449-8596
EI 1836-5655
J9 J SPAT SCI
JI J. Spat. Sci.
PD JAN 2
PY 2016
VL 61
IS 1
BP 69
EP 97
DI 10.1080/14498596.2015.1051147
PG 29
WC Geography, Physical; Remote Sensing
SC Physical Geography; Remote Sensing
GA DI9PQ
UT WOS:000373835300002
ER
PT J
AU Garneau, CJ
Parkinson, MB
AF Garneau, Christopher J.
Parkinson, Matthew B.
TI A survey of anthropometry and physical accommodation in ergonomics
curricula
SO ERGONOMICS
LA English
DT Article
DE Ergonomics tools and methods; anthropometry; ergonomics education;
physical ergonomics
ID DESIGN
AB The size and shape of users are an important consideration for many products and environments. Designers and engineers in many disciplines must often accommodate these attributes to meet objectives such as fit and safety. When practitioners have academic training in addressing these issues, it is typically through courses in Human Factors/Ergonomics (HF/E). This paper investigates education related to physical accommodation and offers suggestions for improvement. A survey was conducted wherein 21 instructors at 18 universities in the United States provided syllabi for 29 courses, which were analysed to determine topics related to anthropometry and resources used for the courses. The results show that within the US, anthropometry is covered in the majority of courses discussing physical ergonomics, but important related concepts were often omitted (e.g. digital human modelling, multivariate accommodation and variability across global populations). Curricula could be improved by incorporating more accurate anthropometry, multivariate problems and interactive online tools.
Practitioner Summary: This paper describes a study investigating collegiate ergonomics courses within the US in the area of physical accommodation. Course schedules and texts were studied for their treatment of several topics related to accommodating the spatial requirements (anthropometry) of users. Recommendations are made for improving course curricula.
C1 [Parkinson, Matthew B.] Penn State Univ, Engn Design Mech Engn & Ind Engn, University Pk, PA 16802 USA.
[Garneau, Christopher J.] US Army, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD USA.
RP Garneau, CJ (reprint author), US Army, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD USA.
EM christopher.j.garneau.civ@mail.mil
NR 44
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U1 1
U2 3
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0014-0139
EI 1366-5847
J9 ERGONOMICS
JI Ergonomics
PD JAN 2
PY 2016
VL 59
IS 1
BP 143
EP 154
DI 10.1080/00140139.2015.1052853
PG 12
WC Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology
SC Engineering; Psychology
GA DG4KE
UT WOS:000372040300013
PM 26849430
ER
PT J
AU Bot, A
Bailey, C
Brumeanu, T
Casares, S
Kuppuswamy, K
Zaghouani, H
AF Bot, Adrian
Bailey, Celeste
Brumeanu, Teodor
Casares, Sofia
Kuppuswamy, Kasturi
Zaghouani, Habib
TI Constantin A. Bona, M.D., Ph.D. OBITUARY
SO INTERNATIONAL REVIEWS OF IMMUNOLOGY
LA English
DT Biographical-Item
C1 [Bot, Adrian] Kite Pharma Inc, Int Reviews Immunol, 2225 Colorado Ave, Santa Monica, CA 90404 USA.
[Bot, Adrian] Kite Pharma Inc, Translat Sci, 2225 Colorado Ave, Santa Monica, CA 90404 USA.
[Bailey, Celeste] AMCR Inst, Escondido, CA USA.
[Bailey, Celeste] Natl Univ, San Diego, CA USA.
[Brumeanu, Teodor] Uniformed Serv Univ Hlth Sci, Dept Med Mol & Cell Biol, Bethesda, MD 20814 USA.
[Casares, Sofia] Walter Reed Army Inst Res, US Mil Malaria Vaccine Program, Preclin Res, Naval Med Res Center, Silver Spring, MD USA.
[Kuppuswamy, Kasturi] US FDA, US Dept HHS, Washington, DC 20204 USA.
[Zaghouani, Habib] Univ Missouri, Mol Microbiol & Immunol, Columbia, MO USA.
RP Bot, A (reprint author), Kite Pharma Inc, Int Reviews Immunol, 2225 Colorado Ave, Santa Monica, CA 90404 USA.; Bot, A (reprint author), Kite Pharma Inc, Translat Sci, 2225 Colorado Ave, Santa Monica, CA 90404 USA.
EM abot@kitepharma.com
NR 1
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PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0883-0185
EI 1563-5244
J9 INT REV IMMUNOL
JI Int. Rev. Immunol.
PD JAN 2
PY 2016
VL 35
IS 1
BP 1
EP 3
DI 10.3109/08830185.2016.1139991
PG 3
WC Immunology
SC Immunology
GA DG5EN
UT WOS:000372098300001
PM 26959800
ER
PT J
AU Harris, C
Milton, DJ
AF Harris, Cameron
Milton, Daniel James
TI Is Standing for Women a Stand Against Terrorism? Exploring the
Connection Between Women's Rights and Terrorism
SO JOURNAL OF HUMAN RIGHTS
LA English
DT Article
ID TRANSNATIONAL TERRORISM; GENDER INEQUALITY; INTERNAL CONFLICT; FEMALE
TERRORISM; CHILD WITNESSES; VETO PLAYERS; CIVIL-WAR; VIOLENCE;
DEMOCRACY; EQUALITY
AB Previous large-N studies have found that the advancement of women's rights leads to a decline in conflict, but no large-N research has explored the possibility of a similar relationship between women's rights and terrorism. Nevertheless, policymakers have long argued that the advancement of women's rights forms a key component of counterterrorism policy. Simply put, we lay out a rationale for the argument that increased women's rights reduce the likelihood of terrorism. We test this hypothesis using CIRI's women's rights data combined with two datasets accounting for domestic terrorism and the production of transnational terrorism. While the results show that women's rights overall are not a panacea for both types of terrorism, the provision of women's rights is shown to have a negative relationship with domestic terrorism. States and international institutions should take the differing effects of women's rights across different types of terrorism into account when designing counterterrorism policies.
C1 [Harris, Cameron] Georgetown Univ, Secur Studies, Washington, DC 20057 USA.
[Milton, Daniel James] US Mil Acad, Dept Social Sci, West Point, NY 10996 USA.
RP Milton, DJ (reprint author), US Mil Acad, Combating Terrorism Ctr, 607 Cullum Rd, West Point, NY 10996 USA.
EM Daniel.Milton@usma.edu
NR 69
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U1 8
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PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1475-4835
EI 1475-4843
J9 J HUM RIGHTS
JI J. Hum. Rights
PD JAN 2
PY 2016
VL 15
IS 1
BP 60
EP 78
DI 10.1080/14754835.2015.1062722
PG 19
WC International Relations; Political Science
SC International Relations; Government & Law
GA DE0BW
UT WOS:000370290700004
ER
PT J
AU Perkins, MW
Wong, B
Rodriguez, A
Devorak, JL
Dao, TT
Leuschner, JA
Kan, RK
Sciuto, AM
AF Perkins, Michael W.
Wong, Benjamin
Rodriguez, Ashley
Devorak, Jennifer L.
Dao, Thuy T.
Leuschner, Jessica A.
Kan, Robert K.
Sciuto, Alfred M.
TI Vapor inhalation exposure to soman in conscious untreated rats:
preliminary assessment of neurotoxicity
SO INHALATION TOXICOLOGY
LA English
DT Article
DE Chemical warfare nerve agents; cholinesterases; inhalation exposure;
neurotoxicity; soman
ID STATUS EPILEPTICUS; INDUCED SEIZURES; NERVE AGENTS; BRAIN;
ACETYLCHOLINESTERASE; NEUROPATHOLOGY; SPECIFICITY; MECHANISMS; SARIN
AB Neurological toxicity and brain injury following vapor inhalation exposure to the chemical warfare nerve agent (CWNA) soman (GD) were examined in untreated non-anesthetized rats. In this study, male Sprague-Dawley rats (300-350g) were exposed to 600mgxmin/m(3) of soman or vehicle in a customized head-out inhalation system for 7min. Convulsant animals were observed for clinical signs and various regions of the brain (dorsolateral thalamus, basolateral amygdala, piriform cortex, and lateral cortex) were collected for pathological observations 24h post-exposure. Signs of CWNA-induced cholinergic crises including salivation, lacrimation, increased urination and defecation, and tremors were observed in all soman-exposed animals. Soman-exposed animals at 24h post-exposure lost 11% of their body weight in comparison to 2% in vehicle-exposed animals. Whole blood acetylcholinesterase (AChE) activity was significantly inhibited in all soman-exposed groups in comparison to controls. Brain injury was confirmed by the neurological assessment of hematoxylin-eosin (H&E) staining and microscopy in the piriform cortex, dorsolateral thalamus, basolateral amygdala, and lateral cortex. Severe damage including prominent lesions, edematous, congested, and/or hemorrhagic tissues was observed in the piriform cortex, dorsolateral thalamus, and lateral cortex in soman-exposed animals 24h post-exposure, while only minimal damage was observed in the basolateral amygdala. These results indicate that inhalation exposure to soman vapor causes neurological toxicity and brain injury in untreated unanesthetized rats. This study demonstrates the ability of the described soman vapor inhalation exposure model to cause neurological damage 24h post-exposure in rats.
C1 [Perkins, Michael W.; Wong, Benjamin; Rodriguez, Ashley; Devorak, Jennifer L.; Dao, Thuy T.; Leuschner, Jessica A.; Kan, Robert K.; Sciuto, Alfred M.] US Army, Med Res Inst Chem Def, Analyt Toxicol Branch, Aberdeen Proving Ground, MD 21010 USA.
RP Perkins, MW (reprint author), US Army, Med Res Inst Chem Def, Analyt Toxicol Div, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA.
EM michael.w.perkins1.civ@mail.mil
FU Oak Ridge Associated Universities
FX Special thanks to the Comparative Pathology Branch for providing
outstanding pathology support. AR and JL are supported by the Oak Ridge
Associated Universities. The experimental protocol was approved by the
Animal Care and Use Committee at the United States Army Medical Research
Institute of Chemical Defense and all procedures were conducted in
accordance with the principles stated in the Guide for the Care and Use
of Laboratory Animals and the Animal Welfare Act of 1966 (P.L. 89-544),
as amended. The views expressed in this article are those of the
author(s) and do not reflect the official policy of the Department of
Army, Department of Defense, or the U.S. Government.
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U2 4
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0895-8378
EI 1091-7691
J9 INHAL TOXICOL
JI Inhal. Toxicol.
PD JAN 2
PY 2016
VL 28
IS 1
BP 14
EP 21
DI 10.3109/08958378.2015.1125973
PG 8
WC Toxicology
SC Toxicology
GA DD3VM
UT WOS:000369851200003
PM 26711353
ER
PT J
AU Jain, RB
Choi, YS
AF Jain, Ram B.
Choi, Y. Sammy
TI Interacting effects of selected trace and toxic metals on thyroid
function
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
LA English
DT Article
DE manganese; iron; copper; zinc; cadmium; lead; mercury; selenium; thyroid
ID NUTRITION EXAMINATION SURVEY; CAFFEINE CONSUMPTION; NATIONAL-HEALTH;
HORMONE LEVELS; UNITED-STATES; MANGANESE; ZINC; POPULATION; SELENIUM;
ASSOCIATION
AB Interacting effects of blood levels of manganese (Mn), selenium, cadmium (Cd), lead (Pb), and mercury, and serum levels of iron (Fe), zinc (Zn), and copper (Cu) on thyroid function in general US population were evaluated. Data from the National Health and Nutrition Examination Survey for 2011-2012 were used for this evaluation. The variables used to evaluate thyroid function were as follows: thyroid-stimulating hormone, free and total triiodothyronine (FT3, TT3), free and total thyroxine (FT4, TT4), and thyroglobulin (Tg). Levels of FT4 were positively associated with the levels of copper and negatively associated with the levels of Fe for males only. Elevated levels of Mn and Fe were associated with increased levels of FT3 for both males and females. TT4 had a positive association with the levels of Cu and a negative association with the levels of Fe for both males and females.
C1 [Jain, Ram B.; Choi, Y. Sammy] Womack Army Med Ctr, Dept Clin Invest, Ft Bragg, NC USA.
[Jain, Ram B.] Empiristat Inc, Mt Airy, MD USA.
RP Jain, RB (reprint author), Womack Army Med Ctr, Dept Clin Invest, Ft Bragg, NC USA.
EM ram.b.jain.ctr@mail.mil
NR 34
TC 1
Z9 1
U1 1
U2 9
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0960-3123
EI 1369-1619
J9 INT J ENVIRON HEAL R
JI Int. J. Environ. Health Res.
PD JAN 2
PY 2016
VL 26
IS 1
BP 75
EP 91
DI 10.1080/09603123.2015.1020416
PG 17
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA DB9CF
UT WOS:000368813000005
PM 25788177
ER
PT J
AU Gerhardt, RT
Reeves, PT
Kotwal, RS
Mabry, RL
Robinson, JB
Butler, F
AF Gerhardt, Robert T.
Reeves, Patrick T.
Kotwal, Russ S.
Mabry, Robert L.
Robinson, John B.
Butler, Frank
TI ANALYSIS OF PREHOSPITAL DOCUMENTATION OF INJURY-RELATED PAIN ASSESSMENT
AND ANALGESIC ADMINISTRATION ON THE CONTEMPORARY BATTLEFIELD
SO PREHOSPITAL EMERGENCY CARE
LA English
DT Article
DE emergency medical services; war; pain-therapy; military medicine;
analgesic agents
ID COMBAT CASUALTY CARE; POSTTRAUMATIC-STRESS-DISORDER; THEATER TRAUMA
REGISTRY; MORPHINE; KETAMINE; MANAGEMENT; FENTANYL; SAFETY; IRAQ
AB In addition to life-saving interventions, the assessment of pain and subsequent administration of analgesia are primary benchmarks for quality emergency medical services care which should be documented and analyzed. Analyze US combat casualty data from the Department of Defense Trauma Registry (DoDTR) with a primary focus on prehospital pain assessment, analgesic administration and documentation. Retrospective cohort study of battlefield prehospital and hospital casualty data were abstracted by DoDTR from available records from 1 September 2007 through 30 June 2011. Data included demographics; injury mechanism; prehospital and initial combat hospital pain assessment documented by standard 0-to-10 numeric rating scale; analgesics administered; and survival outcome. Records were available for 8,913 casualties (median ISS of 5 [IQR 2 to 10]; 98.7% survived). Prehospital analgesic administration was documented for 1,313 cases (15%). Prehospital pain assessment was recorded for 581 cases (7%; median pain score 6 [IQR 3 to 8]), hospital pain assessment was recorded for 5,007 cases (56%; median pain score5 [CI95% 3 to 8]), and 409 cases (5%) had both prehospital and hospital pain assessments that could be paired. In this paired group, 49.1% (201/409) had alleviation of pain evidenced by a decrease in pain score (median 4,, IQR 2 to 5); 23.5% (96/409) had worsening of pain evidenced by an increase in pain score (median 3, CI95 2.8 to 3.7, IQR 1 to 5); 27.4% (112/409) had no change; and the overall difference was an average decrease in pain score of 1.1 (median 0, IQR 0 to 3, p < 0.01). Time-series analysis showed modest increases in prehospital and hospital pain assessment documentation and prehospital analgesic documentation. Our study demonstrates that prehospital pain assessment, management, and documentation remain primary targets for performance improvement on the battlefield. Results of paired prehospital to hospital pain scores and time-series analysis demonstrate both feasibility and benefit of prehospital analgesics. Future efforts must also include an expansion of the prehospital battlefield analgesic formulary.
C1 [Gerhardt, Robert T.] Brooke Army Med Ctr, Emergency Med, San Antonio, TX 78234 USA.
[Reeves, Patrick T.] Univ Texas Med Branch, Sch Med, Galveston, TX 77555 USA.
[Kotwal, Russ S.] USA Inst Surg Res, Joint Trauma Syst, Jbsa Ft Sam Houston, TX USA.
[Mabry, Robert L.] USAISR, JTS, San Antonio, TX USA.
[Robinson, John B.] DMRTI, San Antonio, TX USA.
[Butler, Frank] US Mil Joint Trauma Syst, San Antonio, TX USA.
RP Gerhardt, RT (reprint author), Brooke Army Med Ctr, Emergency Med, 3851 Roger Brooke Dr, San Antonio, TX 78234 USA.
EM robert.gerhardt@us.army.mil
RI Reeves, Patrick/F-8348-2016
OI Reeves, Patrick/0000-0002-1217-9795
NR 34
TC 2
Z9 2
U1 4
U2 5
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1090-3127
EI 1545-0066
J9 PREHOSP EMERG CARE
JI Prehosp. Emerg. Care
PD JAN 2
PY 2016
VL 20
IS 1
BP 37
EP 44
DI 10.3109/10903127.2015.1051683
PG 8
WC Emergency Medicine; Public, Environmental & Occupational Health
SC Emergency Medicine; Public, Environmental & Occupational Health
GA DA1DI
UT WOS:000367536100006
PM 26727337
ER
PT J
AU Harmon, LM
Cooper, RL
Nugent, WR
Butcher, JJ
AF Harmon, Lisa M.
Cooper, R. Lyle
Nugent, William R.
Butcher, Jimmie J.
TI A review of the effectiveness of military suicide prevention programs in
reducing rates of military suicides
SO JOURNAL OF HUMAN BEHAVIOR IN THE SOCIAL ENVIRONMENT
LA English
DT Review
DE Armed forces; military; prevention program; suicide
ID RISK; CHOICE; ARMY
AB The suicide rate within the U.S. armed forces remains a pressing issue for the country. This comprehensive literature review found only five published studies on military suicide prevention programs and their outcomes. Substantial research design and methodological issues are noted, and only one study produces statistically significant results. Findings reveal a serious lack of empirical evidence demonstrating effective suicide prevention programs within the U.S. armed forces.
C1 [Harmon, Lisa M.; Cooper, R. Lyle; Nugent, William R.] Univ Tennessee, Coll Social Work, Knoxville, TN 37996 USA.
[Butcher, Jimmie J.] Tripler Army Med Ctr, Dept Army, Honolulu, HI 96859 USA.
RP Harmon, LM (reprint author), Univ Tennessee, Coll Social Work, Knoxville, TN 37996 USA.
EM lharmon629@yahoo.com
NR 23
TC 0
Z9 0
U1 0
U2 7
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1091-1359
EI 1540-3556
J9 J HUM BEHAV SOC ENVI
JI J. Hum. Behav. Soc. Environ.
PD JAN 2
PY 2016
VL 26
IS 1
SI SI
BP 15
EP 24
DI 10.1080/10911359.2015.1058139
PG 10
WC Social Work
SC Social Work
GA CW8XT
UT WOS:000365283400003
ER
PT J
AU Walsh, ME
AF Walsh, Marianne E.
TI Analytical Methods for Detonation Residues of Insensitive Munitions
SO JOURNAL OF ENERGETIC MATERIALS
LA English
DT Article
DE DNAN; IMX-101; IMX-104; NTO; NQ
ID PERFORMANCE LIQUID-CHROMATOGRAPHY; MASS-SPECTROMETRY; NITROGUANIDINE;
NTO; 2,4-DINITROANISOLE; EXPLOSIVES; SEPARATION; PRODUCTS; IMX-104
AB Analytical methods are described for the analysis of post-detonation residues from insensitive munitions. Standard methods were verified or modified to obtain the mass of residues deposited per round. In addition, a rapid chromatographic separation was developed and used to measure the mass of NTO (3-nitro-1,2,4-triazol-5-one), NQ (nitroguanidine) and DNAN (2,4-dinitroanisole). The HILIC (hydrophilic-interaction chromatography) separation described here uses a trifunctionally-bonded amide phase to retain the polar analytes. The eluent is 75/25 v/v acetonitrile/water acidified with acetic acid, which is also suitable for LC/MS applications. Analytical runtime was three minutes. Solid phase extraction and LC/MS conditions are also described.
C1 US Army, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA.
RP Walsh, ME (reprint author), US Army, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA.
EM Marianne.E.Walsh@usace.army.mil
FU SERDP [ER-2219]
FX Support for this project was provided by the Strategic Environmental
Research and Development Program, Andrea Leeson, Environmental
Restoration Program Manager. Tests were conducted as a task within SERDP
ER-2219, Michael R. Walsh and Sonia Thiboutot, Principal Investigators.
The author thanks anonymous reviewers for constructive comments that
improved the manuscript.
NR 22
TC 1
Z9 1
U1 6
U2 20
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0737-0652
EI 1545-8822
J9 J ENERG MATER
JI J. Energ. Mater.
PD JAN 2
PY 2016
VL 34
IS 1
BP 76
EP 91
DI 10.1080/07370652.2014.999173
PG 16
WC Chemistry, Applied; Chemistry, Physical; Engineering, Chemical;
Materials Science, Multidisciplinary
SC Chemistry; Engineering; Materials Science
GA CW1VK
UT WOS:000364779700007
ER
PT S
AU Ding, W
Ganesh, MR
Severinghaus, RN
Corso, JJ
Panagou, D
AF Ding, Wei
Ganesh, Madan Ravi
Severinghaus, Robert N.
Corso, Jason J.
Panagou, Dimitra
GP IEEE
TI Real-Time Model Predictive Control for Keeping a Quadrotor Visible on
the Camera Field-of-View of a Ground Robot
SO 2016 AMERICAN CONTROL CONFERENCE (ACC)
SE Proceedings of the American Control Conference
LA English
DT Proceedings Paper
CT American Control Conference (ACC)
CY JUL 06-08, 2016
CL Boston, MA
SP Amer Automat Control Council
ID AERIAL
AB This paper considers a cooperative control design for an aerial/ground robot system, and addresses the problem of maintaining visibility of a quadrotor within the camera field-of-view of a ground robot in the presence of external disturbances. The quadrotor needs to be tracked by the ground robot with a monocular camera, and hence its motion should facilitate the ground vision-based tracking process by remaining in the effective camera sensing area. We design a model predictive controller (MPC) strategy where the visibility constraints of the camera and the control input constraints of the quadrotor are encoded into the cost function via barrier functions, and we adopt a fast MPC solver that is able to solve the optimization problem in real time. We also propose a method to enhance the robustness of the algorithm by suitably defining a restart method for the MPC solver. The applicability of the proposed algorithm is demonstrated through simulations and experimental results on real setups.
C1 [Ding, Wei; Panagou, Dimitra] Univ Michigan, Dept Aerosp Engn, Ann Arbor, MI 48109 USA.
[Ganesh, Madan Ravi; Corso, Jason J.] Univ Michigan, Dept Elect Engn & Comp Sci, Ann Arbor, MI 48109 USA.
[Severinghaus, Robert N.] US Army TARDEC, Warren, MI USA.
RP Ding, W (reprint author), Univ Michigan, Dept Aerosp Engn, Ann Arbor, MI 48109 USA.
EM weiding@umich.edu; madantrg@umich.edu;
robert.n.severinghaus.civ@mail.mil; jjcorso@umich.edu;
dpanagou@umich.edu
FU U.S. Army TARDEC [W56HZV-14-2-0001]
FX This work was supported in part by U.S. Army TARDEC under agreement
W56HZV-14-2-0001.
NR 32
TC 0
Z9 0
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 0743-1619
BN 978-1-4673-8682-1
J9 P AMER CONTR CONF
PY 2016
BP 2259
EP 2264
PG 6
WC Automation & Control Systems
SC Automation & Control Systems
GA BG3XW
UT WOS:000388376102052
ER
PT S
AU Paris, V
Strizic, T
Pusey, J
Byl, K
AF Paris, Virgile
Strizic, Tom
Pusey, Jason
Byl, Katie
GP IEEE
TI Tools for the Design of Stable yet Nonsteady Bounding Control
SO 2016 AMERICAN CONTROL CONFERENCE (ACC)
SE Proceedings of the American Control Conference
LA English
DT Proceedings Paper
CT American Control Conference (ACC)
CY JUL 06-08, 2016
CL Boston, MA
SP Amer Automat Control Council
AB Control efforts on dynamic gaits for legged systems traditionally focus on limit cycles and their stability. However, there are many practical situations where step-tostep variability is highly desirable, for example to achieve variable footholds or to recover and replan after perturbations. In this paper we present an effective, high-level switching control framework for overcoming terrain obstacles using the familiar A* algorithm to search a mesh over the reachable space for a given set of controllers. In support of this, we present new low-level control strategies for generating stable bounding with planar models of a spring-legged quadruped robot, and demonstrate their use crossing gaps in the terrain.
C1 [Paris, Virgile] ENSEIRB MATMECA, Bordeaux Inst Technol, 1 Ave Dr Albert Schweitzer,BP 99, F-33402 Talence, France.
[Strizic, Tom; Byl, Katie] Univ Calif Santa Barbara, Dept Elect & Comp Engn, Santa Barbara, CA 93106 USA.
[Pusey, Jason] US Army, Res Lab, Aberdeen Proving Ground, MD USA.
RP Paris, V (reprint author), ENSEIRB MATMECA, Bordeaux Inst Technol, 1 Ave Dr Albert Schweitzer,BP 99, F-33402 Talence, France.
EM paris.vgle@gmail.com; tstrizic@ece.ucsb.edu; jason.l.pusey.civ@mail.mil;
katiebyl@ece.ucsb.edu
FU U.S. Army's Robotics CTA [W911NF-08-R-0012]; NSF CAREER award [CMMI
1255018]; Summer Student Research Participation Program at the U.S. Army
Research Laboratory
FX This work was supported in part by the U.S. Army's Robotics CTA through
grant No. W911NF-08-R-0012, by an NSF CAREER award (CMMI 1255018), and
by the Summer Student Research Participation Program at the U.S. Army
Research Laboratory administered by the Oak Ridge Institute for Science
and Education.
NR 21
TC 0
Z9 0
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 0743-1619
BN 978-1-4673-8682-1
J9 P AMER CONTR CONF
PY 2016
BP 4822
EP 4828
PG 7
WC Automation & Control Systems
SC Automation & Control Systems
GA BG3XW
UT WOS:000388376104148
ER
PT S
AU Allik, B
Piovoso, MJ
Zurakowski, R
AF Allik, Bethany
Piovoso, Michael J.
Zurakowski, Ryan
GP IEEE
TI Recursive Estimation with Quantized and Censored Measurements
SO 2016 AMERICAN CONTROL CONFERENCE (ACC)
SE Proceedings of the American Control Conference
LA English
DT Proceedings Paper
CT American Control Conference (ACC)
CY JUL 06-08, 2016
CL Boston, MA
SP Amer Automat Control Council
AB In this paper, we extend the Tobit Kalman filter for quantized measurements. Quantization occurs in many applications and systems and can usually be neglected in cases where the quantization interval is small. If this is not the case, the quantization effects cannot be ignored, and the nonlinearity induced by the quantizer must be addressed. Particle filters can be used, but are computationally expensive. Recently, the Tobit Kalman filter has been used to provide estimates when the measurement is a piecewise nonlinear censored regression model. The Tobit Kalman filter for quantized measurements derived in this paper is a computationally efficient algorithm, which converges to the optimal Kalman filter when quantization intervals become small. The derived estimator is compared to the Cramer Rao lower bound and the particle filter.
C1 [Allik, Bethany] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Piovoso, Michael J.; Zurakowski, Ryan] Univ Delaware, Newark, DE 19716 USA.
RP Allik, B (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM bethany.l.allik.civ@mail.mil; ryanz@udel.edu; piovoso@udel.edu
FU Army Research Office [W911NF-10-1-0386]
FX This work is supported by the Army Research Office under grant number
W911NF-10-1-0386
NR 24
TC 0
Z9 0
U1 1
U2 1
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 0743-1619
BN 978-1-4673-8682-1
J9 P AMER CONTR CONF
PY 2016
BP 5130
EP 5135
PG 6
WC Automation & Control Systems
SC Automation & Control Systems
GA BG3XW
UT WOS:000388376105033
ER
PT S
AU Cook, JT
Ray, LE
Lever, JH
AF Cook, Joshua T.
Ray, Laura E.
Lever, James H.
GP IEEE
TI Dynamics Model for Mobility Optimization and Control of Off-Road Tractor
Convoys
SO 2016 AMERICAN CONTROL CONFERENCE (ACC)
SE Proceedings of the American Control Conference
LA English
DT Proceedings Paper
CT American Control Conference (ACC)
CY JUL 06-08, 2016
CL Boston, MA
SP Amer Automat Control Council
AB This paper presents a generalized vehicle mode and leader-follower control architecture for an off-road, skid steered tracked vechicle. the modeling approach couples existing formulations in the literature for the powertrain components and the vechicle-terrain interaction to provide a comprehensive model that captures the salient features of terrain trafficability and predicts the vehicle's response over snow. this coupling is essential for making realistic predictions of the vechicle's mobility capabilities due to the power-load relationship at the engine output. simulation results show that over similar terrain,towing conditions, and input, neighboring trajectories of a leader-follower pair results, and controllers therefore need only to make small refinements to the control input. however, as the vechicles encounter different terrain and the risk of immobilization increase, an alternative control law is needed. under these circumstances, the model can be used for short term trajectoey prediction.
C1 [Cook, Joshua T.; Ray, Laura E.] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA.
[Lever, James H.] US Army Cold Reg Res & Engn Lab, Hanover, NH USA.
RP Cook, JT (reprint author), Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA.
EM joshua.t.cook.th@dartmouth.edu; lray@dartmouth.edu;
james.lever@erdc.dren.mil
FU NASA [NNX-10AL97H]
FX This work was supported by NASA grant NNX-10AL97H
NR 23
TC 0
Z9 0
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 0743-1619
BN 978-1-4673-8682-1
J9 P AMER CONTR CONF
PY 2016
BP 6875
EP 6880
PG 6
WC Automation & Control Systems
SC Automation & Control Systems
GA BG3XW
UT WOS:000388376106154
ER
PT S
AU Cruz, PJ
Sadler, BM
Fierro, R
AF Cruz, Patricio J.
Sadler, Brian M.
Fierro, Rafael
GP IEEE
TI Sensor Localization Using Hybrid RF/Optical Wireless Communications for
an Aerial Data Mule
SO 2016 AMERICAN CONTROL CONFERENCE (ACC)
SE Proceedings of the American Control Conference
LA English
DT Proceedings Paper
CT American Control Conference (ACC)
CY JUL 06-08, 2016
CL Boston, MA
SP Amer Automat Control Council
AB In this paper we consider the problem of pairing a ground sensor with an aerial vehicle, both equipped with a hybrid communication system - radio frequency for non-line of sight transmission and optical for line-of-sight transmission. These communication technologies are complementary and by coordinating them it is possible to mitigate their respective weaknesses. A challenging problem is positioning the flying robot within optical communication range, especially when the distance is large and the sensor location is unknown. In this work, we propose a solution to the problem of autonomously localizing the sensor node relative to the aerial vehicle. We take advantage of the hybrid communication scheme by developing a control strategy that uses the radio signal to guide the aerial platform to the sensor node. Once the optical-based signal strength is over a desired threshold the robot hovers within optical range. The control strategy is demonstrated through simulations that incorporate a realistic model for the hybrid communication link.
C1 [Cruz, Patricio J.; Fierro, Rafael] Univ New Mexico, Dept Elect & Comp Engn, Albuquerque, NM 87131 USA.
[Sadler, Brian M.] Army Res Lab, Adelphi, MD 20783 USA.
RP Cruz, PJ (reprint author), Univ New Mexico, Dept Elect & Comp Engn, Albuquerque, NM 87131 USA.
EM pcruzec@unm.edu; brian.m.sadler6.civ@mail.mil; rfierro@unm.edu
FU ARL MAST CTA [W911NF-08-2-0004]; SENESCYT Ecuadorian Scholarship Program
FX This work was supported in part by ARL MAST CTA #W911NF-08-2-0004. We
would like to thank the SENESCYT Ecuadorian Scholarship Program for
providing part of the financial support of P. J. Cruz.
NR 25
TC 0
Z9 0
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 0743-1619
BN 978-1-4673-8682-1
J9 P AMER CONTR CONF
PY 2016
BP 7085
EP 7091
PG 7
WC Automation & Control Systems
SC Automation & Control Systems
GA BG3XW
UT WOS:000388376107025
ER
PT S
AU Lee, H
Kwon, H
AF Lee, Hyungtae
Kwon, Heesung
GP IEEE
TI CONTEXTUAL DEEP CNN BASED HYPERSPECTRAL CLASSIFICATION
SO 2016 IEEE INTERNATIONAL GEOSCIENCE AND REMOTE SENSING SYMPOSIUM (IGARSS)
SE IEEE International Symposium on Geoscience and Remote Sensing IGARSS
LA English
DT Proceedings Paper
CT 36th IEEE International Geoscience and Remote Sensing Symposium (IGARSS)
CY JUL 10-15, 2016
CL Beijing, PEOPLES R CHINA
SP Inst Elect & Elect Engineers, Inst Elect & Elect Engineers, Geoscience & Remote Sensing Soc, NSSC
DE contextual deep CNN; joint spectral and spatial exploitation;
hyperspectral classification
AB In this paper, we describe a novel deep convolutional neural networks (CNN) based approach called contextual deep CNN that can jointly exploit spatial and spectral features for hyperspectral image classification. The contextual deep CNN first concurrently applies multiple 3-dimensional local convolutional filters with different sizes jointly exploiting spatial and spectral features of a hyperspectral image. The initial spatial and spectral feature maps obtained from applying the variable size convolutional filters are then combined together to form a joint spatio-spectral feature map. The joint feature map representing rich spectral and spatial properties of the hyperspectral image is then fed through fully convolutional layers that eventually predict the corresponding label of each pixel vector. The proposed approach is tested on two benchmark datasets: the Indian Pines dataset and the Pavia University scene dataset. Performance comparison shows enhanced classification performance of the proposed approach over the current state of the art on both datasets.
C1 [Lee, Hyungtae; Kwon, Heesung] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
RP Lee, H (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
NR 7
TC 0
Z9 0
U1 1
U2 1
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 2153-6996
BN 978-1-5090-3332-4
J9 INT GEOSCI REMOTE SE
PY 2016
BP 3322
EP 3325
PG 4
WC Engineering, Electrical & Electronic; Geosciences, Multidisciplinary;
Remote Sensing
SC Engineering; Geology; Remote Sensing
GA BG3QG
UT WOS:000388114603087
ER
PT S
AU Gilani, SN
Sheetz, K
Lucas, G
Traum, D
AF Gilani, Setareh Nasihati
Sheetz, Kraig
Lucas, Gale
Traum, David
BE Traum, D
Swartout, W
Khooshabeh, P
Kopp, S
Scherer, S
Leuski, A
TI What Kind of Stories Should a Virtual Human Swap?
SO INTELLIGENT VIRTUAL AGENTS, IVA 2016
SE Lecture Notes in Artificial Intelligence
LA English
DT Proceedings Paper
CT 16th International Conference on Intelligent Virtual Agents (IVA)
CY SEP 20-23, 2016
CL Los Angeles, CA
SP Alelo, Springer, Univ So Calif, Inst Creat Technologies
AB Telling stories is an important aspect virtual agents designed to interact with people socially over time. We describe an experiment designed to investigate the impact of the identity, presentation form, and perspective of a virtual storyteller on a human user who engages in a story-swapping activity with two virtual characters. For each interaction, the user was given 10 "ice-breaker" questions to ask a virtual character and respond to the character's reciprocal request. Participants also filled out a post-interaction survey, measuring rapport with the character and impressions of the character's personality. Results generally show that participants prefer characters who tell first person stories, however there were some interactions with presentation order. No significant preferences were established for the form or identity variables.
C1 [Gilani, Setareh Nasihati; Lucas, Gale; Traum, David] USC Inst Creat Technol, 12015 Waterfront Dr, Playa Vista, CA 90094 USA.
[Sheetz, Kraig] US Mil Acad, West Point, NY 10996 USA.
RP Gilani, SN (reprint author), USC Inst Creat Technol, 12015 Waterfront Dr, Playa Vista, CA 90094 USA.
EM sngilani@ict.usc.edu; Kraig.Sheetz2@usma.edu; lucas@ict.usc.edu;
traum@ict.usc.edu
NR 22
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
SN 0302-9743
BN 978-3-319-47665-0; 978-3-319-47664-3
J9 LECT NOTES ARTIF INT
PY 2016
VL 10011
BP 128
EP 140
DI 10.1007/978-3-319-47665-0_12
PG 13
WC Computer Science, Artificial Intelligence
SC Computer Science
GA BG6GQ
UT WOS:000390287300012
ER
PT S
AU Hobbs, RL
AF Hobbs, Reginald L.
BE Traum, D
Swartout, W
Khooshabeh, P
Kopp, S
Scherer, S
Leuski, A
TI A Distributed Intelligent Agent Approach to Context in Information
Retrieval
SO INTELLIGENT VIRTUAL AGENTS, IVA 2016
SE Lecture Notes in Artificial Intelligence
LA English
DT Proceedings Paper
CT 16th International Conference on Intelligent Virtual Agents (IVA)
CY SEP 20-23, 2016
CL Los Angeles, CA
SP Alelo, Springer, Univ So Calif, Inst Creat Technologies
DE Intelligent agents; Natural language processing; Fuzzy logic; Quality of
information
AB Information retrieval across disadvantaged networks requires intelligent agents that can make decisions about what to transmit in such a way as to minimize network performance impact while maximizing utility and quality of information (QOI). Specialized agents at the source need to process unstructured, ad-hoc queries, identifying both the context and the intent to determine the implied task. Knowing the task will allow the distributed agents that service the requests to filter, summarize, or transcode data prior to responding, lessening the network impact. This paper describes an approach that uses natural language processing (NLP) techniques, multi-valued logic based inferencing, distributed intelligent agents, and task-relevant metrics for information retrieval.
C1 [Hobbs, Reginald L.] US Army, Res Lab, Adelphi, MD 20783 USA.
RP Hobbs, RL (reprint author), US Army, Res Lab, Adelphi, MD 20783 USA.
EM reginald.l.hobbs2.civ@mail.mil
NR 6
TC 0
Z9 0
U1 1
U2 1
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
SN 0302-9743
BN 978-3-319-47665-0; 978-3-319-47664-3
J9 LECT NOTES ARTIF INT
PY 2016
VL 10011
BP 475
EP 478
DI 10.1007/978-3-319-47665-0_58
PG 4
WC Computer Science, Artificial Intelligence
SC Computer Science
GA BG6GQ
UT WOS:000390287300058
ER
PT S
AU Marge, M
Bonial, C
Pollard, KA
Artstein, R
Byrne, B
Hill, SG
Voss, C
Traum, D
AF Marge, Matthew
Bonial, Claire
Pollard, Kimberly A.
Artstein, Ron
Byrne, Brendan
Hill, Susan G.
Voss, Clare
Traum, David
BE Traum, D
Swartout, W
Khooshabeh, P
Kopp, S
Scherer, S
Leuski, A
TI Assessing Agreement in Human-Robot Dialogue Strategies: A Tale of Two
Wizards
SO INTELLIGENT VIRTUAL AGENTS, IVA 2016
SE Lecture Notes in Artificial Intelligence
LA English
DT Proceedings Paper
CT 16th International Conference on Intelligent Virtual Agents (IVA)
CY SEP 20-23, 2016
CL Los Angeles, CA
SP Alelo, Springer, Univ So Calif, Inst Creat Technologies
DE Natural language dialogue; Human-robot communication
AB The Wizard-of-Oz (WOz) method is a common experimental technique in virtual agent and human-robot dialogue research for eliciting natural communicative behavior from human partners when full autonomy is not yet possible. For the first phase of our research reported here, wizards play the role of dialogue manager, acting as a robot's dialogue processing. We describe a novel step within WOz methodology that incorporates two wizards and control sessions: the wizards function much like corpus annotators, being asked to make independent judgments on how the robot should respond when receiving the same verbal commands in separate trials. We show that inter-wizard discussion after the control sessions and the resolution with a reconciled protocol for the follow-on pilot sessions successfully impacts wizard behaviors and significantly aligns their strategies. We conclude that, without control sessions, we would have been unlikely to achieve both the natural diversity of expression that comes with multiple wizards and a better protocol for modeling an automated system.
C1 [Marge, Matthew; Pollard, Kimberly A.; Byrne, Brendan; Hill, Susan G.; Voss, Clare] US Army, Res Lab, Adelphi, MD 20783 USA.
[Artstein, Ron; Traum, David] USC Inst Creat Technol, Playa Vista, CA 90094 USA.
RP Marge, M (reprint author), US Army, Res Lab, Adelphi, MD 20783 USA.
EM matthew.r.marge.civ@mail.mil
NR 4
TC 0
Z9 0
U1 1
U2 1
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
SN 0302-9743
BN 978-3-319-47665-0; 978-3-319-47664-3
J9 LECT NOTES ARTIF INT
PY 2016
VL 10011
BP 484
EP 488
DI 10.1007/978-3-319-47665-0_60
PG 5
WC Computer Science, Artificial Intelligence
SC Computer Science
GA BG6GQ
UT WOS:000390287300060
ER
PT S
AU McDaniel, S
Boothe, DL
Crone, JC
Park, SJ
Shires, DR
Yu, AB
Taufer, M
AF McDaniel, Sean
Boothe, David L.
Crone, Joshua C.
Park, Song J.
Shires, Dale R.
Yu, Alfred B.
Taufer, Michela
BE Liao, X
Lovas, R
Shen, X
Zheng, R
TI Study of Neocortex Simulations with GENESIS on High Performance
Computing Resources
SO 2016 IEEE 22ND INTERNATIONAL CONFERENCE ON PARALLEL AND DISTRIBUTED
SYSTEMS (ICPADS)
SE International Conference on Parallel and Distributed Systems -
Proceedings
LA English
DT Proceedings Paper
CT 22nd IEEE International Conference on Parallel and Distributed Systems
(ICPADS)
CY DEC 13-16, 2016
CL Wuhan, PEOPLES R CHINA
SP IEEE, IEEE Comp Soc, Huazhong Univ Sci & Technol
ID NEURONS
AB One significant challenge in neuroscience is understanding the cooperative behavior of large numbers of neurons. Models of neuronal networks allow scientists to explore the impact of differential neuronal connectivity using analysis techniques and information not available experimentally. However, modeling realistic neurobiological processes and encoding them in computer simulations is challenging, as increasing computing and data requirements are all of concern. In this work we study the performance of neocortex simulations using GEneral NEural SImulation System (GENESIS), a well-known multi-function brain simulation package, supported by high performance computing resources. The contribution of our work is threefold. First, we study the impact of platforms (i.e., single fat nodes versus high-end clusters) and their features on the performance and data generation for a small scale model of neocortex. Second, we assess the impact of the model complexity (i.e., number of cells and cell connectivity) on the performance and data generation for increasingly large versions of the neocortex model on high-end clusters. Third, we provide selected scientific results obtained by increasing the model complexity. We show that the more realistic and rigorous modeling of neocortex functions is computationally feasible but requires high performance computing resources to mitigate the growing computing and data requests of the associated simulations.
C1 [McDaniel, Sean; Taufer, Michela] Univ Delaware, Newark, DE 19716 USA.
[Boothe, David L.] Army Res Lab, Altus Engn, Aberdeen Proving Ground, MD USA.
[Crone, Joshua C.; Park, Song J.; Shires, Dale R.; Yu, Alfred B.] US Army Res Lab, Aberdeen Proving Ground, MD USA.
RP McDaniel, S (reprint author), Univ Delaware, Newark, DE 19716 USA.
EM seanmcd@udel.edu; david.l.boothe7.ctr@mail.mil;
joshua.crone.civ@mail.mil; song.j.park@mail.mil; dale.r.shires@mail.mil;
alfred.b.yu.civ@mail.mil; taufer@udel.edu
FU U.S. Army Research Laboratory [N911NF-15-2003]
FX This work was supportd by the U.S. Army Research Laboratory under
Cooperative Agreement Number N911NF-15-2003.
NR 17
TC 0
Z9 0
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 1521-9097
BN 978-1-5090-4457-3
J9 INT C PAR DISTRIB SY
PY 2016
BP 924
EP 931
DI 10.1109/ICPADS.2016.122
PG 8
WC Computer Science, Hardware & Architecture
SC Computer Science
GA BG9GX
UT WOS:000393188800114
ER
PT S
AU Singh, PK
Nguyen, JH
Gupta, SK
Kar, K
Ku, D
AF Singh, Prateek K.
Nguyen, James H.
Gupta, Santosh K.
Kar, Koushik
Ku, Daniel
GP IEEE
TI High Performance Mass Configuration Protocols for MANETs using Efficient
Broadcasting
SO 2016 IEEE 35TH INTERNATIONAL PERFORMANCE COMPUTING AND COMMUNICATIONS
CONFERENCE (IPCCC)
SE IEEE International Performance Computing and Communications Conference
(IPCCC)
LA English
DT Proceedings Paper
CT 35th IEEE International Performance Computing and Communications
Conference (IPCCC)
CY DEC 09-11, 2016
CL Las Vegas, NV
SP IEEE
ID AD-HOC NETWORKS
AB In this work we present the design and evaluation of two high performance mass configuration protocols, focusing on efficiency and reliability, for wireless Mobile Ad-hoc Networks (MANETs) utilizing an Efficient Broadcast Module (EBM). MCONF, which was developed in an earlier work, enables mass configuration changes in a MANET using multiple modes of operation based on the underlying network scenario. However, MCONF relies on classic flooding approach to disseminate configuration changes and gather feedback information to/from nodes. In this paper we propose: S-MCONF - a Simple Mass Configuration protocol focusing on efficiency, and E-MCONF - an Efficient Mass Configuration protocol focusing on reliability. Both of these are developed based on MCONF while utilizing underlying efficient broadcasting framework that computes a Minimum Connected Dominating Set (MCDS) to forward messages in a MANET. Our proposed S-MCONF and E-MCONF protocols utilize three different relay selection algorithms, namely Essential Connecting Dominating Set (E-CDS), Source based MultiPoint Relay (S-MPR) and Non-source specific MultiPoint Relay (NS-MPR), to optimize performance. We evaluate the performance of our S-MCONF and E-MCONF protocols by emulating MANET on Common Open Research Emulator (CORE) for dynamic topologies based on mobility of nodes. Performance is measured in terms of reliability and packet redundancy. Based on our findings as part of the study, it is observed that S-MCONF is very well suited for low node mobility scenarios in the MANETs. On the other hand, E-MCONF provides reliability of packet delivery in MANETs even for high node mobility scenarios. Both S-MCONF and E-MCONF are able to improve their packet efficiency significantly at low mobility as compared to MCONF protocol.
C1 [Singh, Prateek K.; Gupta, Santosh K.; Kar, Koushik] Rensselaer Polytech Inst, Troy, NY 12180 USA.
[Nguyen, James H.; Ku, Daniel] US Army, CERDEC, Aberdeen Proving Ground, MD 21005 USA.
RP Singh, PK (reprint author), Rensselaer Polytech Inst, Troy, NY 12180 USA.
FU RDECOM Contracting Center; RTP Division; Army Research Laboratory
[W911NF-09-D-0006]; Raytheon BBN Technologies Corp.
FX The research reported in this work was supported by the RDECOM
Contracting Center, RTP Division and the Army Research Laboratory under
Contract Number W911NF-09-D-0006 under a subcontract from Raytheon BBN
Technologies Corp. The views and conclusions contained in this work are
those of the authors and should not be interpreted as presenting the
official policies or position, either expressed or implied, of the
RDECOM Contracting Center, RTP Division and the Army Research Laboratory
or the U.S. Government unless so designated by other official documents.
Citation of manufacturers or trade names does not constitute an official
endorsement or approval of the use thereof. The U.S. Government is
authorized to reproduce and distribute reprints for Government purposes
notwithstanding any copyright notation hereon.
NR 25
TC 0
Z9 0
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 1097-2641
BN 978-1-5090-5252-3
J9 IEEE IPCCC
PY 2016
PG 10
WC Computer Science, Hardware & Architecture; Engineering, Electrical &
Electronic; Telecommunications
SC Computer Science; Engineering; Telecommunications
GA BG9QB
UT WOS:000393582600024
ER
PT J
AU Brantly, AF
AF Brantly, Aaron F.
TI Aesop's wolves: the deceptive appearance of espionage and attacks in
cyberspace
SO INTELLIGENCE AND NATIONAL SECURITY
LA English
DT Article
AB Appearances in cyberspace are deceptive and problematic. Deception in the cyber domain poses an immensely difficult challenge for states to differentiate between espionage activities in cyberspace and cyber attacks. The inability to distinguish between cyber activities places US cyber infrastructure in a perilous position and increases the possibility of a disproportionate or inadequate response to cyber incidents. This paper uses case analysis to examine the characteristics associated with the tools and decisions related to cyber espionage and cyber attacks to develop a framework for distinction leveraging epidemiological models for combating disease.
C1 [Brantly, Aaron F.] US Mil Acad, Dept Social Sci, Int Relat & Cybersecur, West Point, NY 10996 USA.
[Brantly, Aaron F.] US Mil Acad, Army Cyber Inst, West Point, NY 10996 USA.
[Brantly, Aaron F.] US Mil Acad, Combating Terrorism Ctr, West Point, NY 10996 USA.
RP Brantly, AF (reprint author), US Mil Acad, Dept Social Sci, Int Relat & Cybersecur, West Point, NY 10996 USA.; Brantly, AF (reprint author), US Mil Acad, Army Cyber Inst, West Point, NY 10996 USA.; Brantly, AF (reprint author), US Mil Acad, Combating Terrorism Ctr, West Point, NY 10996 USA.
EM aaron.brantly@usma.edu
NR 21
TC 0
Z9 0
U1 0
U2 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0268-4527
EI 1743-9019
J9 INTELL NATL SECUR
JI Intell. Natl. Secur.
PY 2016
VL 31
IS 5
BP 674
EP 685
DI 10.1080/02684527.2015.1077620
PG 12
WC International Relations
SC International Relations
GA EL1CF
UT WOS:000394357400002
ER
PT J
AU Chang, W
Tetlock, PE
AF Chang, Welton
Tetlock, Philip E.
TI Rethinking the training of intelligence analysts
SO INTELLIGENCE AND NATIONAL SECURITY
LA English
DT Article
ID ERROR MANAGEMENT THEORY; DECISION-MAKING; ACCURACY; UNDERCONFIDENCE;
PSYCHOLOGY; EVOLUTION; BIASES; OVERCONFIDENCE; OVERREACTION; PROBABILITY
AB Despite intense scrutiny and promised fixes resulting from intelligence 'transformation' efforts, erroneous analytic assessments persist and continue to dominate news coverage of the US intelligence community. Existing analytic training teaches analysts about common cognitive biases and then aims to correct them with structured analytic techniques. On its face, this approach is eminently reasonable; on close inspection, incomplete and imbalanced. Current training is anchored in a mid-twentieth century understanding of psychology that focuses on checking over-confidence and rigidity but ignores the problems of under-confidence and excessive volatility. Moreover it has never been validated against objective benchmarks of good judgment. We propose a new approach: (a) adopting scientifically validated content and regularly testing training to avoid institutionalizing new dogmas; (b) incentivizing analysts to view training guidelines as means to the end of improved accuracy, not an end in itself.
C1 [Chang, Welton] Univ Penn, Philadelphia, PA 19104 USA.
[Chang, Welton] US Army, Ft Belvoir, VA 22060 USA.
[Chang, Welton] Def Intelligence Agcy, Washington, DC 20340 USA.
[Tetlock, Philip E.] Univ Penn, Psychol, Philadelphia, PA 19104 USA.
[Tetlock, Philip E.] Univ Penn, Wharton Sch, Philadelphia, PA 19104 USA.
[Tetlock, Philip E.] Univ Penn, Polit Sci, Philadelphia, PA 19104 USA.
RP Chang, W (reprint author), Univ Penn, Philadelphia, PA 19104 USA.; Chang, W (reprint author), US Army, Ft Belvoir, VA 22060 USA.; Chang, W (reprint author), Def Intelligence Agcy, Washington, DC 20340 USA.
EM welton@sas.upenn.edu
FU Wharton Global Initiatives program
FX We thank the Wharton Global Initiatives program for its generous support
of our research and Kelsie Piedra for assistance with manuscript
preparation. We also thank Jeffrey Friedman, David Mandel, Mark Parker,
Carrie Plummer, and three anonymous reviewers for their insightful
comments and critiques.
NR 116
TC 0
Z9 0
U1 0
U2 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0268-4527
EI 1743-9019
J9 INTELL NATL SECUR
JI Intell. Natl. Secur.
PY 2016
VL 31
IS 6
SI SI
BP 903
EP 920
DI 10.1080/02684527.2016.1147164
PG 18
WC International Relations
SC International Relations
GA EL1CI
UT WOS:000394357700009
ER
PT J
AU Grew, KN
McClure, JP
Chu, D
Kohl, PA
Ahlfield, JM
AF Grew, Kyle N.
McClure, Joshua P.
Chu, Deryn
Kohl, Paul A.
Ahlfield, John M.
TI Understanding Transport at the Acid-Alkaline Interface of Bipolar
Membranes
SO JOURNAL OF THE ELECTROCHEMICAL SOCIETY
LA English
DT Article
ID ANION-EXCHANGE MEMBRANES; FIXED CHARGE MEMBRANES; P-N-JUNCTIONS;
ION-TRANSPORT; FUEL-CELLS; WATER DISSOCIATION; REACTION-KINETICS;
CARBON-DIOXIDE; HYBRID ANION; ELECTROLYTE
AB The combination of cation exchange membrane (CEM) and anion exchange membrane (AEM) electrolytes to form of a hybrid, or bipolar membrane (BPM) electrolyte, can have unique advantages for electrochemical systems including fuel cells, electrolyzers, electrodialysis, and photovoltaic solar-to-fuel devices. However, a major challenge for this approach is the development of a stable and active interfacial region (i.e., junction) that adjoins the CEM and AEM layers. Moreover, a fundamental understanding of transport at the CEM-AEM junction is lacking. Therefore, the present study focuses on the theoretical development and analysis of the nature of the BPM interface. A Poisson-Nernst-Planck (PNP) theory is formalized and applied to a representative BPM interface. The findings are reported in terms of bias (i.e., overpotential) in a galvanic device with respect to CEM and AEM material requirements. Specific attention is paid to our interests in the application of the BPM to a fuel cell device with an acidic (CEM) anode and alkaline (AEM) cathode. We demonstrate that a BPM with an acidic CEM anode and alkaline AEM cathode must promote a trap-assisted type of recombination mechanism under forward bias. Without such a mechanism, large overpotentials are needed to drive ionic recombination processes. (C) The Author(s) 2016. Published by ECS. All rights reserved.
C1 [Grew, Kyle N.; McClure, Joshua P.; Chu, Deryn] US Army, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
[Kohl, Paul A.; Ahlfield, John M.] Georgia Inst Technol, Sch Chem & Bimol Engn, Atlanta, GA 30332 USA.
RP Grew, KN (reprint author), US Army, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
EM kyle.n.grew.civ@mail.mil
FU U.S. Department of the Army; U.S. Army Material Command (AMC); U.S.
Office of the Deputy Assistant Secretary of the Army for Defense Exports
and Cooperation (DASA-DEC); U.S. Army Research Laboratory
[W911NF-14-2-0008]
FX KNG, JPM, and DC gratefully acknowledge the U.S. Department of the Army
and U.S. Army Material Command (AMC) for supporting this work. PAK and
JMA gratefully acknowledge financial support from the from the U.S.
Office of the Deputy Assistant Secretary of the Army for Defense Exports
and Cooperation (DASA-DE&C) and the U.S. Army Research Laboratory,
W911NF-14-2-0008. The authors would also like to thank Dr. David Baker &
Dr. Oleg Borodin of the U.S. Army Research Laboratory and Ms. Lisha Liu
of Georgia Tech for helpful discussions.
NR 55
TC 0
Z9 0
U1 4
U2 4
PU ELECTROCHEMICAL SOC INC
PI PENNINGTON
PA 65 SOUTH MAIN STREET, PENNINGTON, NJ 08534 USA
SN 0013-4651
EI 1945-7111
J9 J ELECTROCHEM SOC
JI J. Electrochem. Soc.
PY 2016
VL 163
IS 14
BP F1572
EP F1587
DI 10.1149/2.0941614jes
PG 16
WC Electrochemistry; Materials Science, Coatings & Films
SC Electrochemistry; Materials Science
GA EK3TV
UT WOS:000393852200113
ER
PT J
AU Mackie, DM
Jahnke, JP
Benyamin, MS
Sumner, JJ
AF Mackie, David M.
Jahnke, Justin P.
Benyamin, Marcus S.
Sumner, James J.
TI Simple, fast, and accurate methodology for quantitative analysis using
Fourier transform infrared spectroscopy, with bio-hybrid fuel cell
examples
SO METHODSX
LA English
DT Article
DE Fourier transform infrared; FTIR; Quantitative analysis; Methodology;
Fuel cell
ID IR; DISCRIMINATION; IDENTIFICATION; FTIR
AB The standard methodologies for quantitative analysis (QA) of mixtures using Fourier transform infrared (FTIR) instruments have evolved until they are now more complicated than necessary for many users' purposes. We present a simpler methodology, suitable for widespread adoption of FTIR QA as a standard laboratory technique across disciplines by occasional users.
Algorithm is straightforward and intuitive, yet it is also fast, accurate, and robust.
Relies on component spectra, minimization of errors, and local adaptive mesh refinement.
Tested successfully on real mixtures of up to nine components.
We show that our methodology is robust to challenging experimental conditions such as similar substances, component percentages differing by three orders of magnitude, and imperfect (noisy) spectra. As examples, we analyze biological, chemical, and physical aspects of bio-hybrid fuel cells. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
C1 [Mackie, David M.; Jahnke, Justin P.; Benyamin, Marcus S.; Sumner, James J.] US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
RP Mackie, DM (reprint author), US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM david.m.mackie.civ@mail.mil
NR 13
TC 1
Z9 1
U1 1
U2 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 2215-0161
J9 METHODSX
JI MethodsX
PY 2016
VL 3
BP 128
EP 138
DI 10.1016/j.mex.2016.02.002
PG 11
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA EJ7KQ
UT WOS:000393401000015
PM 26977411
ER
PT S
AU Akogwu, I
Wang, N
Zhang, CY
Hong, HX
Choi, H
Gong, P
AF Akogwu, Isaac
Wang, Nan
Zhang, Chaoyang
Hong, Huixiao
Choi, Hwanseok
Gong, Ping
BE Tian, T
Jiang, Q
Liu, Y
Burrage, K
Song, J
Wang, Y
Hu, X
Morishita, S
Zhu, Q
Wang, G
TI Factorial Analysis of Error Correction Performance Using Simulated
Next-Generation Sequencing Data
SO 2016 IEEE INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICINE
(BIBM)
SE IEEE International Conference on Bioinformatics and Biomedicine-BIBM
LA English
DT Proceedings Paper
CT IEEE International Conference on Bioinformatics and Biomedicine (IEEE
BIBM)
CY DEC 15-18, 2016
CL Shenzhen, PEOPLES R CHINA
SP IEEE, IEEE Comp Soc, Natl Sci Fdn, Harbin Inst Technol
DE next-generation sequencing; performance metrics; error correction;
multi-way ANOVA; k-mer spectrum; genome size; read length; coverage
depth; simulation study; precision; F-score
ID SINGLE-NUCLEOTIDE VARIANTS; READS; BIAS
AB Error correction is a critical initial step in next-generation sequencing (NGS) data analysis. Although more than 60 tools have been developed, there is no systematic evidence-based comparison with regard to their strength and weakness, especially in terms of correction accuracy. Here we report a full factorial simulation study to examine how NGS dataset characteristics (genome size, coverage depth and read length in particular) affect error correction performance (precision and F-score), as well as to compare performance sensitivity/resistance of six k-mer spectrum-based methods to variations in dataset characteristics. Multi-way ANOVA tests indicate that choice of correction method and dataset characteristics had significant effects on performance metrics. Overall, BFC, Bless, Bloocoo and Musket performed better than Lighter and Trowel on 27 synthetic datasets. For each chosen method, read length and coverage depth showed more pronounced impact on performance than genome size. This study shed insights to the performance behavior of error correction methods in response to the common variables one would encounter in real-world NGS datasets. It also warrants further studies of wet lab-generated experimental NGS data to validate findings obtained from this simulation study.
C1 [Akogwu, Isaac; Wang, Nan; Zhang, Chaoyang] Univ Southern Mississippi, Sch Comp, Hattiesburg, MS 39406 USA.
[Hong, Huixiao] US FDA, Div Bioinformat & Biostat, Natl Ctr Toxicol Res, Jefferson, AR USA.
[Choi, Hwanseok] Univ Southern Mississippi, Dept Publ Hlth, Hattiesburg, MS 39406 USA.
[Gong, Ping] US Army Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS USA.
RP Zhang, CY (reprint author), Univ Southern Mississippi, Sch Comp, Hattiesburg, MS 39406 USA.
EM Chaoyang.zhang@usm.edu; Ping.Gong@usace.army.mil
FU U.S. Army Environmental Quality/Installation (EQI) Basic Research
Program; National Science Foundation [EPS 0903787]
FX This work was supported by an intramural grant from the U.S. Army
Environmental Quality/Installation (EQI) Basic Research Program to PG
and a sub-award of National Science Foundation award EPS 0903787 to CZ
and NW. Permission was granted by the Chief of Engineer to publish this
paper.
NR 24
TC 0
Z9 0
U1 0
U2 0
PU IEEE COMPUTER SOC
PI LOS ALAMITOS
PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1264 USA
SN 2156-1125
BN 978-1-5090-1610-5
J9 IEEE INT C BIOINFORM
PY 2016
BP 1164
EP 1169
PG 6
WC Computer Science, Interdisciplinary Applications; Medical Informatics
SC Computer Science; Medical Informatics
GA BG9GY
UT WOS:000393191700200
ER
PT J
AU Koppel, A
Fink, J
Warnell, G
Stump, E
Ribeiro, A
AF Koppel, Alec
Fink, Jonathan
Warnell, Garrett
Stump, Ethan
Ribeiro, Alejandro
GP IEEE
TI Online Learning for Characterizing Unknown Environments in Ground
Robotic Vehicle Models
SO 2016 IEEE/RSJ INTERNATIONAL CONFERENCE ON INTELLIGENT ROBOTS AND SYSTEMS
(IROS 2016)
LA English
DT Proceedings Paper
CT IEEE/RSJ International Conference on Intelligent Robots and Systems
(IROS)
CY OCT 09-14, 2016
CL Daejeon, SOUTH KOREA
SP IEEE, RSJ
ID MINIMIZATION; PREDICTION
AB In pursuit of increasing the operational tempo of a ground robotics platform in unknown domains, we consider the problem of predicting the distribution of structural state-estimation error due to poorly-modeled platform dynamics as well as environmental effects. Such predictions are a critical component of any modern control approach that utilizes uncertainty information to provide robustness in control design. We use an online learning algorithm based on matrix factorization techniques to fit a statistical model of error that provides enough expressive power to enable prediction directly from motion control signals and low-level visual features. Moreover, we empirically demonstrate that this technique compares favorably to predictors that do not incorporate this information.
C1 [Koppel, Alec; Ribeiro, Alejandro] Univ Penn, Dept ESE, 200 South 33rd St, Philadelphia, PA 19104 USA.
[Fink, Jonathan; Warnell, Garrett; Stump, Ethan] US Army, Res Lab, Computat & Informat Sci Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
RP Koppel, A (reprint author), Univ Penn, Dept ESE, 200 South 33rd St, Philadelphia, PA 19104 USA.
EM akoppel@seas.upenn.edu; jonathan.r.fink3.civ@mail.mil;
garrett.a.warnell.civ@mail.mil; ethan.a.stump2.civ@mail.mil;
aribeiro@seas.upenn.edu
FU ASEE SMART; ARL MAST CTA
FX Work in this paper is supported by ASEE SMART and ARL MAST CTA.
NR 24
TC 0
Z9 0
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-5090-3762-9
PY 2016
BP 626
EP 633
PG 8
WC Computer Science, Artificial Intelligence; Robotics
SC Computer Science; Robotics
GA BG7XO
UT WOS:000391921700092
ER
PT J
AU Twigg, JN
Gregory, JM
Fink, JR
AF Twigg, Jeffrey N.
Gregory, Jason M.
Fink, Jonathan R.
GP IEEE
TI Towards Online Characterization of Autonomously Navigating Robots in
Unstructured Environments
SO 2016 IEEE/RSJ INTERNATIONAL CONFERENCE ON INTELLIGENT ROBOTS AND SYSTEMS
(IROS 2016)
LA English
DT Proceedings Paper
CT IEEE/RSJ International Conference on Intelligent Robots and Systems
(IROS)
CY OCT 09-14, 2016
CL Daejeon, SOUTH KOREA
SP IEEE, RSJ
AB Autonomous platforms are confronted by a diversity of challenges in unstructured environments, which make monitoring performance a non-trivial task. Some of these environments are so complex that they preclude persistent, nearby operator oversight. This absence of oversight motivates the need for an online monitoring system, specifically for robots operating in difficult environments. We develop a test methodology and set of online monitoring metrics by extending methods for characterizing robotic-systems using offline metrics. We implement this test methodology in an unstructured, outdoor environment and show the resulting performance information gained from our online monitoring solution. This online monitoring approach is generalizable such that it characterizes any robotic system that meets our set of hardware and software criteria.
C1 [Twigg, Jeffrey N.; Gregory, Jason M.; Fink, Jonathan R.] US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
RP Twigg, JN (reprint author), US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM jeffrey.n.twigg.civ@mail.mil; jason.m.gregory1.civ@mail.mil;
jonathan.r.fink3.civ@mail.mil
NR 24
TC 0
Z9 0
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-5090-3762-9
PY 2016
BP 1198
EP 1205
PG 8
WC Computer Science, Artificial Intelligence; Robotics
SC Computer Science; Robotics
GA BG7XO
UT WOS:000391921701055
ER
PT J
AU Li, C
Kessens, CC
Young, A
Fearing, RS
Full, RJ
AF Li, Chen
Kessens, Chad C.
Young, Austin
Fearing, Ronald S.
Full, Robert J.
GP IEEE
TI Cockroach-inspired winged robot reveals principles of ground-based
dynamic self-righting
SO 2016 IEEE/RSJ INTERNATIONAL CONFERENCE ON INTELLIGENT ROBOTS AND SYSTEMS
(IROS 2016)
LA English
DT Proceedings Paper
CT IEEE/RSJ International Conference on Intelligent Robots and Systems
(IROS)
CY OCT 09-14, 2016
CL Daejeon, SOUTH KOREA
SP IEEE, RSJ
ID DESIGN; MANIPULATION; CAPABILITIES; LOCOMOTION; INSECTA
AB Animals and robots alike face challenges of flipping-over as they move in complex terrain. Small insects like cockroaches can rapidly right themselves when upside down, yet small fast-running legged robots are much less capable of ground-based self-righting. Inspired by the discoid cockroach that opens its wings to push against the ground to self-right, we designed actuated wings for robot self-righting based on recently-developed rounded shells for obstacle traversal In We measured the self-righting performance of a robot using these actuated wings, and systematically studied the effects and trade-offs of wing opening magnitude, speed, symmetry, and wing geometry. Our study provided a proof-of-concept that robots can take advantage of an existing body structure (rounded shell) in novel ways (as actuated wings) to serve new locomotor functions, analogous to biological exaptations [2]. Our results demonstrated that the robot self-rights dynamically, with active wing pushing followed by passive falling, and benefits from increasing kinetic energy by pushing faster and longer. Our experiments also showed that opening both wings asymmetrically increases righting probability at low wing opening magnitudes.
C1 [Li, Chen] Johns Hopkins Univ, Baltimore, MD 21218 USA.
[Kessens, Chad C.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Young, Austin; Fearing, Ronald S.; Full, Robert J.] Univ Calif Berkeley, Berkeley, CA 94720 USA.
RP Li, C (reprint author), Johns Hopkins Univ, Baltimore, MD 21218 USA.
EM chen.li@jhu.edu
FU Burroughs Wellcome Fund Career Award at the Scientific Interface (C.L.);
Miller Institute for Basic Research in Science; University of
California, Berkeley (C.L.); United States Army Research Laboratory
under the Micro Autonomous Science and Technology Collaborative Contract
(C.C.K., R.J.F)
FX This work is supported by Burroughs Wellcome Fund Career Award at the
Scientific Interface (C.L.), Miller Institute for Basic Research in
Science, University of California, Berkeley (C.L.), and United States
Army Research Laboratory under the Micro Autonomous Science and
Technology Collaborative Contract (C.C.K., R.J.F).
NR 36
TC 0
Z9 0
U1 1
U2 1
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-5090-3762-9
PY 2016
BP 2128
EP 2134
PG 7
WC Computer Science, Artificial Intelligence; Robotics
SC Computer Science; Robotics
GA BG7XO
UT WOS:000391921702044
ER
PT J
AU Lee, H
Kwon, H
Robinson, RM
Donavanik, D
Nothwang, WD
Marathe, AR
AF Lee, Hyungtae
Kwon, Heesung
Robinson, Ryan M.
Donavanik, Daniel
Nothwang, William D.
Marathe, Amar R.
GP IEEE
TI Task-conversions for Integrating Human and Machine Perception in a
Unified Task
SO 2016 IEEE/RSJ INTERNATIONAL CONFERENCE ON INTELLIGENT ROBOTS AND SYSTEMS
(IROS 2016)
LA English
DT Proceedings Paper
CT IEEE/RSJ International Conference on Intelligent Robots and Systems
(IROS)
CY OCT 09-14, 2016
CL Daejeon, SOUTH KOREA
SP IEEE, RSJ
AB The different strategies fir feature extraction and synthesis employed by humans and computers are often complementary, hence combining the two into an integrated object recognition system may considerably improve performance over either used in isolation. Rapid Serial Visual Presentation (RSVP) is one well-established technique that has shown promise integrating human perception into a machine perception system. In this paper, we apply computer vision techniques to image data filtered through human RSVP. We introduce "task conversions" to integrate the two modalities, applying the precise localization capabilities of computer vision with the detection capabilities of RSVP. We employ naive Bayesian fusion and a novel method, dynamic belief fusion (DBF), in a joint scheme as fusion approaches. Preliminary experiments demonstrate that DBF extracts complementary information from both human and machine sources to improve performance for both target classification and object detection.
C1 [Lee, Hyungtae] Boor Allen Hamilton Inc, Mclean, VA 22102 USA.
[Lee, Hyungtae; Kwon, Heesung; Robinson, Ryan M.; Donavanik, Daniel; Nothwang, William D.] Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
[Marathe, Amar R.] Army Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD USA.
RP Lee, H (reprint author), Boor Allen Hamilton Inc, Mclean, VA 22102 USA.; Lee, H (reprint author), Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
EM lee_hyungtae@bah.com; heesung.kwon.civ@mail.mil;
ryan.robinson14.ctr@mail.mil; daniel.donavanik.ctr@mail.mil;
william.d.nothwang.civ@mail.mil; amar.marathe.civ@mail.mil
FU U.S. Army Research Laboratory under a Director's Strategic Research
Initiative entitled Heterogeneous Systems for Information Variable
Environments (HIVE) [FY14-FY16]
FX This project was supported by the U.S. Army Research Laboratory under a
Director's Strategic Research Initiative entitled "Heterogeneous Systems
for Information Variable Environments (HIVE)" from FY14-FY16. The views
and conclusions contained in this document are those of the authors and
should not be interpreted as representing the official policies, either
expressed or implied, of the Army Research Laboratory or U.S.
Government. The U.S. Government is authorized to reproduce and
distribute reprints for Government purposes notwithstanding any
copyright notation herein.
NR 29
TC 0
Z9 0
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-5090-3762-9
PY 2016
BP 2751
EP 2758
PG 8
WC Computer Science, Artificial Intelligence; Robotics
SC Computer Science; Robotics
GA BG7XO
UT WOS:000391921702137
ER
PT J
AU Wigness, M
Rogers, JG
Navarro-Serment, LE
Suppe, A
Draper, BA
AF Wigness, Maggie
Rogers, John G., III
Navarro-Serment, Luis Ernesto
Suppe, Arne
Draper, Bruce A.
GP IEEE
TI Reducing Adaptation Latency for Multi-Concept Visual Perception in
Outdoor Environments
SO 2016 IEEE/RSJ INTERNATIONAL CONFERENCE ON INTELLIGENT ROBOTS AND SYSTEMS
(IROS 2016)
LA English
DT Proceedings Paper
CT IEEE/RSJ International Conference on Intelligent Robots and Systems
(IROS)
CY OCT 09-14, 2016
CL Daejeon, SOUTH KOREA
SP IEEE, RSJ
ID TERRAIN CLASSIFICATION; ROBOT NAVIGATION
AB Multi-concept visual classification is emerging as a common environment perception technique, with applications in autonomous mobile robot navigation. Supervised visual classifiers are typically trained with large sets of images, hand annotated by humans with region boundary outlines followed by label assignment. This annotation is time consuming, and unfortunately, a change in environment requires new or additional labeling to adapt visual perception. The time is takes for a human to label new data is what we call adaptation latency. High adaptation latency is not simply undesirable but may be infeasible for scenarios with limited labeling time and resources. In this paper, we introduce a labeling framework to the environment perception domain that significantly reduces adaptation latency using unsupervised learning in exchange for a small amount of label noise. Using two real-world datasets we demonstrate the speed of our labeling framework, and its ability to collect environment labels that train high performing multi-concept classifiers. Finally, we demonstrate the relevance of this label collection process for visual perception as it applies to navigation in outdoor environments.
C1 [Wigness, Maggie; Rogers, John G., III] US Army Res Lab, Adelphi, MD 20783 USA.
[Navarro-Serment, Luis Ernesto; Suppe, Arne] Carnegie Mellon Univ, Inst Robot, Pittsburgh, PA 15213 USA.
[Draper, Bruce A.] Colorado State Univ, Ft Collins, CO 80523 USA.
RP Wigness, M (reprint author), US Army Res Lab, Adelphi, MD 20783 USA.
NR 36
TC 0
Z9 0
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-5090-3762-9
PY 2016
BP 2784
EP 2791
PG 8
WC Computer Science, Artificial Intelligence; Robotics
SC Computer Science; Robotics
GA BG7XO
UT WOS:000391921702142
ER
PT J
AU Ozaslan, T
Mohta, K
Keller, J
Mulgaonkar, Y
Taylor, CJ
Kumar, V
Wozencraft, JM
Hood, T
AF Ozaslan, Tolga
Mohta, Kartik
Keller, James
Mulgaonkar, Yash
Taylor, Camillo J.
Kumar, Vijay
Wozencraft, Jennifer M.
Hood, Thomas
GP IEEE
TI Towards Fully Autonomous Visual Inspection of Dark Featureless Dam
Penstocks using MAVs
SO 2016 IEEE/RSJ INTERNATIONAL CONFERENCE ON INTELLIGENT ROBOTS AND SYSTEMS
(IROS 2016)
LA English
DT Proceedings Paper
CT IEEE/RSJ International Conference on Intelligent Robots and Systems
(IROS)
CY OCT 09-14, 2016
CL Daejeon, SOUTH KOREA
SP IEEE, RSJ
AB In the last decade, multi-rotor Micro Aerial Vehicles (MAVs) have attracted great attention from robotics researchers. Offering affordable agility and maneuverability, multi-rotor aircrafts have become the most commonly used platforms for robotics applications. Amongst the most promising applications are inspection of power-lines, cell-towers, large and constrained infrastructures and precision agriculture. While GPS offers an easy solution for outdoor autonomy, using on-board sensors is the only solution for autonomy in constrained indoor environments. In this paper, we present our results on autonomous inspection of completely dark, featureless, symmetric dam penstocks using cameras and range sensors. We use a hex-rotor platform equipped with an IMU, four cameras and two lidars. One of the cameras tracks features on the walls using the on-board illumination to estimate the position along the tunnel axis unobservable to range sensors while all of the cameras are used for panoramic image construction. The two lidars estimate the remaining degrees of freedom (DOF). Outputs of the two estimators are fused using an Unscented Kalman Filter (UKF). A moderately trained operator defines waypoints using the Remote Control (RC). We demonstrate our results from Carters Dam, GA and Glen Canyon Dam, AZ which include panoramic images for cracks and rusty spot detection and 6-DOF estimation results with ground truth comparisons. To our knowledge ours is the only study that can autonomously inspect environments with no geometric cues and poor to no external illumination using MAVs.
C1 [Ozaslan, Tolga; Mohta, Kartik; Keller, James; Mulgaonkar, Yash; Taylor, Camillo J.; Kumar, Vijay] Univ Penn, Grasp Lab, Philadelphia, PA 19104 USA.
[Wozencraft, Jennifer M.; Hood, Thomas] USACE, Washington, DC USA.
RP Ozaslan, T (reprint author), Univ Penn, Grasp Lab, Philadelphia,