FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Rettinger, CL Fletcher, JL Carlsson, AH Leung, KP Chan, RK AF Rettinger, C. L. Fletcher, J. L. Carlsson, A. H. Leung, K. P. Chan, R. K. TI IMPROVED WOUND HEALING PARAMETERS IN PORCINE FULL-THICKNESS WOUNDS TRANSPLANTED WITH FULL-THICKNESS SKIN MICROGRAFTS SO WOUND REPAIR AND REGENERATION LA English DT Meeting Abstract C1 [Rettinger, C. L.; Fletcher, J. L.; Carlsson, A. H.; Leung, K. P.; Chan, R. K.] US Army Inst Surg Res, Dent & Trauma Res Directorate, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1067-1927 EI 1524-475X J9 WOUND REPAIR REGEN JI Wound Repair Regen. PD MAR-APR PY 2016 VL 24 IS 2 BP A22 EP A22 PG 1 WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery GA DK8DP UT WOS:000375157700094 ER PT J AU Brennan, LM Widder, MW McAleer, MK Mayo, MW Greis, AP van der Schalie, WH AF Brennan, Linda M. Widder, Mark W. McAleer, Michael K. Mayo, Michael W. Greis, Alex P. van der Schalie, William H. TI Preparation and Testing of Impedance-based Fluidic Biochips with RTgill-W1 Cells for Rapid Evaluation of Drinking Water Samples for Toxicity SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS LA English DT Article DE Environmental Sciences; Issue 109; Fish cells; impedance; sensors; biochip; water toxicity; ECIS; monolayer; field-portable ID CYTOTOXICITY; BIOSENSORS AB This manuscript describes how to prepare fluidic biochips with Rainbow trout gill epithelial (RTgill-W1) cells for use in a field portable water toxicity sensor. A monolayer of RTgill-W1 cells forms on the sensing electrodes enclosed within the biochips. The biochips are then used for testing in a field portable electric cell-substrate impedance sensing (ECIS) device designed for rapid toxicity testing of drinking water. The manuscript further describes how to run a toxicity test using the prepared biochips. A control water sample and the test water sample are mixed with pre-measured powdered media and injected into separate channels of the biochip. Impedance readings from the sensing electrodes in each of the biochip channels are measured and compared by an automated statistical software program. The screen on the ECIS instrument will indicate either "Contamination Detected" or "No Contamination Detected" within an hour of sample injection. Advantages are ease of use and rapid response to a broad spectrum of inorganic and organic chemicals at concentrations that are relevant to human health concerns, as well as the long-term stability of stored biochips in a ready state for testing. Limitations are the requirement for cold storage of the biochips and limited sensitivity to cholinesterase-inhibiting pesticides. Applications for this toxicity detector are for rapid field-portable testing of drinking water supplies by Army Preventative Medicine personnel or for use at municipal water treatment facilities. C1 [Brennan, Linda M.; Widder, Mark W.; van der Schalie, William H.] US Army, Ctr Environm Hlth Res, Ft Detrick, MD 21702 USA. [McAleer, Michael K.; Mayo, Michael W.; Greis, Alex P.] Nanohmics Inc, Austin, TX 78741 USA. RP Brennan, LM (reprint author), US Army, Ctr Environm Hlth Res, Ft Detrick, MD 21702 USA. EM linda.m.brennan2.civ@mail.mil FU US Army Medical Research and Materiel Command; Small Business Innovation Research and Small Business Technology Transfer program [W81XWH-13-C-0093] FX This work was supported by the US Army Medical Research and Materiel Command and by the Small Business Innovation Research and Small Business Technology Transfer program; Contract No. W81XWH-13-C-0093. We would like to thank Dr. Lucy Lee at the University of Fraser for being our RTgill-W1 cell culture mentor, and to acknowledge Dr. Niels Bols of Waterloo University for the development of the RTgill-W1cell line. NR 16 TC 0 Z9 0 U1 3 U2 3 PU JOURNAL OF VISUALIZED EXPERIMENTS PI CAMBRIDGE PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA SN 1940-087X J9 JOVE-J VIS EXP JI J. Vis. Exp. PD MAR PY 2016 IS 109 AR e53555 DI 10.3791/53555 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DK0XR UT WOS:000374636300023 ER PT J AU Austin, KG Farina, EK Lieberman, HR AF Austin, Krista G. Farina, Emily K. Lieberman, Harris R. TI Self-reported side-effects associated with use of dietary supplements in an armed forces population SO DRUG TESTING AND ANALYSIS LA English DT Article DE protein supplements; combination products; body mass index; physical fitness ID MILITARY PERSONNEL; SAFETY; SOLDIERS AB Approximately 60-70% of Armed Forces personnel consume a dietary supplement (DS) at least once a week and there have been numerous reports of severe adverse events among DS users. This study assessed patterns of DS use and self-reported side-effects among 4400 Armed Forces personnel using a paper-and-pencil survey. Multivariable logistic regression was used to examine associations between patterns of DS use and self-reported side-effects. Sixty-nine percent of personnel surveyed reported using a DS. Seven percent of DS users reported experiencing abnormal heart beats, 6% tremors, 5% stomach pain, 3% dizziness, and 3% numbness/tingling and they believed these symptoms were associated with the use of DS. After adjustment for use of other DS classes, total supplement use, and demographic characteristics, protein supplement users were more likely than non-users to report numbness/tingling; combination product users were more likely to report experiencing abnormal heart beats, stomach pain, dizziness, tremors, and numbness/tingling; and users of purported steroid analogues were more likely to report dizziness. Use of more than one DS per week was associated with an increased likelihood of reporting side-effects. Respondents with a higher body mass index were more likely to report side-effects. Further research is necessary to determine whether self-reported side-effects associated with multiple DS use and some DS classes impact the long-term health or performance of service members. Surveillance of military populations using surveys like this one may provide a method for detecting adverse health events of DS before they are apparent in the civilian population. Copyright (c) 2015 John Wiley & Sons, Ltd. C1 [Austin, Krista G.; Farina, Emily K.; Lieberman, Harris R.] US Army, Mil Nutr Div, Environm Med Res Inst, Kansas St,Bldg 42, Natick, MA 01760 USA. [Austin, Krista G.; Farina, Emily K.] Oak Ridge Inst Sci & Educ, Belcamp, MD 21017 USA. RP Lieberman, HR (reprint author), US Army, Mil Nutr Div, Environm Med Res Inst, Kansas St,Bldg 42, Natick, MA 01760 USA. EM harris.r.lieberman.civ@mail.mil FU US Army Medical Research and Materiel Command; Department of Defense Center Alliance for Nutrition and Dietary Supplements Research FX US Army Medical Research and Materiel Command; Department of Defense Center Alliance for Nutrition and Dietary Supplements Research NR 23 TC 1 Z9 1 U1 1 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1942-7603 EI 1942-7611 J9 DRUG TEST ANAL JI Drug Test. Anal. PD MAR-APR PY 2016 VL 8 IS 3-4 SI SI BP 287 EP 295 DI 10.1002/dta.1905 PG 9 WC Biochemical Research Methods; Chemistry, Analytical; Pharmacology & Pharmacy SC Biochemistry & Molecular Biology; Chemistry; Pharmacology & Pharmacy GA DJ5NP UT WOS:000374255900003 PM 26526399 ER PT J AU Snavely, TM AF Snavely, Timothy M. TI A Brief Economic Analysis of the Looming Nursing Shortage In the United States SO NURSING ECONOMICS LA English DT Article AB The United States is projected to experience a nursing shortage in the coming years as market forces begin to shift away from equilibrium. A return to pre-recession work levels, aging baby boomers, and insufficient numbers of nursing graduates adversely affect the supply of nurses The aging population, a rise in chronic care management needs, and the Affordable Care Act will result in an increasing demand for them. Returning to a state of equilibrium is critical if our health care system is to ensure care that is accessible, safe, and cost effective. C1 [Snavely, Timothy M.] US Army, San Antonio, TX USA. RP Snavely, TM (reprint author), US Army, San Antonio, TX USA. NR 23 TC 0 Z9 0 U1 3 U2 4 PU JANNETTI PUBLICATIONS, INC PI PITMAN PA EAST HOLLY AVENUE, BOX 56, PITMAN, NJ 08071-0056 USA SN 0746-1739 J9 NURS ECON JI Nurs. Econ. PD MAR-APR PY 2016 VL 34 IS 2 BP 98 EP 100 PG 3 WC Nursing SC Nursing GA DJ5VE UT WOS:000374277400009 PM 27265953 ER PT J AU Kaplan, D Gong, Y Mills, K Swaminathan, V Ajayan, PM Shirodkar, S Kaxiras, E AF Kaplan, D. Gong, Y. Mills, K. Swaminathan, V. Ajayan, P. M. Shirodkar, S. Kaxiras, E. TI Excitation intensity dependence of photoluminescence from monolayers of MoS2 and WS2/MoS2 heterostructures SO 2D MATERIALS LA English DT Article DE Raman; molybdenum disulfide; CVD; excitation intensity dependence; heterostructure; exciton; trion ID TRANSITION-METAL DICHALCOGENIDES; MOLYBDENUM-DISULFIDE; LAYER MOS2; TRIONS AB A detailed study of the excitation dependence of the photoluminescence (PL) from monolayers of MoS2 and WS2/MoS2 heterostructures grown by chemical vapor deposition on Si substrates has revealed that the luminescence from band edge excitons from MoS2 monolayers shows a linear dependence on excitation intensity for both above band gap and resonant excitation conditions. In particular, a band separated by similar to 55 meV from the A exciton, referred to as the C band, shows the same linear dependence on excitation intensity as the band edge excitons. A band similar to the C band has been previously ascribed to a trion, a charged, three-particle exciton. However, in our study the C band does not show the 3/2 power dependence on excitation intensity as would be expected for a three-particle exciton. Further, the PL from the MoS2 monolayer in a bilayer WS2/MoS2 heterostructure, under resonant excitation conditions where only the MoS2 absorbs the laser energy, also revealed a linear dependence on excitation intensity for the C band, confirming that its origin is not due to a trion but instead a bound exciton, presumably of an unintentional impurity or a native point defect such as a sulfur vacancy. The PL from the WS2/MoS2 heterostructure, under resonant excitation conditions also showed additional features which are suggested to arise from the interface states at the heteroboundary. Further studies are required to clearly identify the origin of these features. C1 [Kaplan, D.; Swaminathan, V.] US Army RDECOM ARDEC, Fuze Precis Armaments & Technol Directorate, Picatinny Arsenal, NJ 07806 USA. [Gong, Y.; Ajayan, P. M.] Rice Univ, Dept Mat Sci & NanoEngn, Houston, TX 77005 USA. [Mills, K.] US Army RDECOM ARDEC, Energet Warheads & Mfg Technol Directorate, Picatinny Arsenal, NJ 07806 USA. [Shirodkar, S.; Kaxiras, E.] Harvard Univ, Dept Phys, Cambridge, MA 02138 USA. [Shirodkar, S.; Kaxiras, E.] Harvard Univ, John A Paulson Sch Engn & Appl Sci, Cambridge, MA 02138 USA. RP Kaplan, D (reprint author), US Army RDECOM ARDEC, Fuze Precis Armaments & Technol Directorate, Picatinny Arsenal, NJ 07806 USA. EM daniel.b.kaplan.civ@mail.mil FU Army Research office MURI [W911NF-11-1-0362, W911NF-14-1-0247] FX YG and PMA would like to acknowledge support by the Army Research office MURI grant W911NF-11-1-0362 and SS and EK would like to acknowledge support by the Army Research office MURI grant W911NF-14-1-0247. NR 27 TC 2 Z9 2 U1 29 U2 73 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 2053-1583 J9 2D MATER JI 2D Mater. PD MAR PY 2016 VL 3 IS 1 AR 015005 DI 10.1088/2053-1583/3/1/015005 PG 10 WC Materials Science, Multidisciplinary SC Materials Science GA DJ1AU UT WOS:000373936300025 ER PT J AU Harrell, LE AF Harrell, L. E. TI Wavefunction collapse through backaction of counting weakly interacting photons SO JOURNAL OF MATHEMATICAL PHYSICS LA English DT Article ID VON-NEUMANN MEASUREMENT; QUANTUM; DECOHERENCE; MODELS AB We apply the formalism of quantum measurement theory to the idealized measurement of the position of a particle with an optical interferometer, finding that the backaction of counting entangled photons systematically collapses the particle's wave-function toward a narrow Gaussian wavepacket at the location x(est) determined by the measurement without appeal to environmental decoherence or other spontaneous collapse mechanism. Further, the variance in the particle's position, as calculated from the post-measurement wavefunction, agrees precisely with shot-noise limited uncertainty of the measured x(est). Both the identification of the absolute square of the particle's initial wavefunction as the probability density for x(est) and the de Broglie hypothesis emerge as consequences of interpreting the intensity of the optical field as proportional to the probability of detecting a photon. Linear momentum information that is encoded in the particle's initial wavefunction survives the measurement, and the pre-measurement expectation values are preserved in the ensemble average. (C) 2016 AIP Publishing LLC. C1 [Harrell, L. E.] US Mil Acad, Dept Phys & Nucl Engn, West Point, NY 10996 USA. RP Harrell, LE (reprint author), US Mil Acad, Dept Phys & Nucl Engn, West Point, NY 10996 USA. EM lee.harrell@usma.edu FU Kavli Institute at Cornell for Nanoscale Science; National Science Foundation [DMR-0634455]; IBM; Eastman Kodak; New York State Office of Science, Technology, and Academic Research; Department of Physics and Nuclear Engineering and the Mathematical Sciences Center of Excellence of the U.S. Military Academy FX I would like to thank John Sidles and Joseph Garbini of the University of Washington for inspiring this work during visits to their labs during July 2005 and June 2012 by teaching me how to develop the measurement operators for the passage of a single photon through an optical interferometer and encouraging me to explore the implications of performing such a measurement iteratively. I would also like to thank the organizers and participants of the international workshop, Magnetic Resonance Force Microscopy: Routes to Three-Dimensional Imaging of Single Molecules, held on June 21-24, 2006, at Cornell University, for many helpful discussions. The workshop was supported by grants from the Kavli Institute at Cornell for Nanoscale Science and the National Science Foundation Under Grant No. DMR-0634455, with additional funding from IBM, Eastman Kodak, and the New York State Office of Science, Technology, and Academic Research. Additional support for this work was provided by the Department of Physics and Nuclear Engineering and the Mathematical Sciences Center of Excellence of the U.S. Military Academy. The views expressed herein are those of the author and do not reflect the position of the Department of the Army or the Department of Defense. NR 40 TC 0 Z9 0 U1 0 U2 3 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0022-2488 EI 1089-7658 J9 J MATH PHYS JI J. Math. Phys. PD MAR PY 2016 VL 57 IS 3 AR 032104 DI 10.1063/1.4944454 PG 10 WC Physics, Mathematical SC Physics GA DJ2DL UT WOS:000374013800010 ER PT J AU Johnson, D Giles, K Acuna, A Saenz, C Bentley, M Budinich, C AF Johnson, Don Giles, Kirk Acuna, Alexis Saenz, Crystal Bentley, Michael Budinich, Craig TI Effects of tibial intraosseous and IV administration of vasopressin on kinetics and survivability in cardiac arrest SO AMERICAN JOURNAL OF EMERGENCY MEDICINE LA English DT Article ID AMERICAN-HEART-ASSOCIATION; EMERGENCY CARDIOVASCULAR CARE; CARDIOPULMONARY-RESUSCITATION; VENTRICULAR-FIBRILLATION; VENOUS ACCESS; EPINEPHRINE; TRIAL; PHARMACOKINETICS; GUIDELINES; UPDATE AB Purpose: Purposes of this study were to compare tibial intraosseous (TIO) and intravenous (IV) administration of vasopressin relative to return of spontaneous circulation (ROSC) and time to ROSC in an adult swine cardiac arrest model. In addition, the purposes were to compare the concentration maximum (Cmax), time to maximum concentration (Tmax), and odds of ROSC. Methods: This was a between-subjects, prospective experimental study. Yorkshire swine (N=21) were randomly assigned to 1 of 3 groups: TIO, IV, or control groups. The swine were anesthetized and instrumented, and then cardiac arrest was induced and sustained for 2 minutes. Cardiopulmonary resuscitation was initiated and continued for 2 minutes. Vasopressin was then administered via the TIO or IV route. Blood samples were collected for 4 minutes to determine the Cmax and Tmax of vasopressin. Concentration maximum and Tmax were calculated by use of liquid chromatography with mass spectrometry. Results: There was no difference in ROSC between the TIO and IV groups (P=.63). The Cmax of vasopressin was significantly higher in the IV group compared to the TIO group (P=.017). However, there was no significant difference in ROSC, time to ROSC, or Tmax between groups (P>.05). All subjects had ROSC in both the IV and TIO groups, and none had ROSC in the control group. There was 225 times greater chance of survival for both the IV and TIO groups compared to the control group. Conclusion: The data support that the TIO is an effective route for vasopressin in a cardiac arrest model. Published by Elsevier Inc. C1 [Johnson, Don; Giles, Kirk; Acuna, Alexis; Saenz, Crystal; Bentley, Michael; Budinich, Craig] Acad Hlth Sci, Dept Army, Ft Sam Houston, TX 78234 USA. [Giles, Kirk; Acuna, Alexis; Saenz, Crystal] US Army, Grad Program Anesthesia Nursing, Washington, DC USA. RP Johnson, D (reprint author), Acad Hlth Sci, Dept Army, Ft Sam Houston, TX 78234 USA. EM arthurjohnso@gmail.com; Giles.k@husky.neu.edu; acuna.a@husky.neu.edu; saenz.c@husky.neu.edu; armygas@gmail.com; craig.budinich@gmail.com FU TriService Nursing Research Program [N13-P10] FX This study was funded with a study from TriService Nursing Research Program grant number (N13-P10). NR 30 TC 0 Z9 0 U1 1 U2 1 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0735-6757 EI 1532-8171 J9 AM J EMERG MED JI Am. J. Emerg. Med. PD MAR PY 2016 VL 34 IS 3 BP 429 EP 432 DI 10.1016/j.ajem.2015.11.027 PG 4 WC Emergency Medicine SC Emergency Medicine GA DI4TB UT WOS:000373491100014 PM 26778642 ER PT J AU Gardony, AL Taylor, HA Brunye, TT AF Gardony, Aaron L. Taylor, Holly A. Brunye, Tad T. TI Gardony Map Drawing Analyzer: Software for quantitative analysis of sketch maps SO BEHAVIOR RESEARCH METHODS LA English DT Article DE Sketch maps; Cognitive mapping; Spatial memory; Mental models ID VISUAL WORKING-MEMORY; BIDIMENSIONAL REGRESSION; ENVIRONMENTS; PERFORMANCE; ABILITIES; LOCATION AB Sketch maps are effective tools for assessing spatial memory. However, despite their widespread use in cognitive science research, sketch map analysis techniques remain unstandardized and carry limitations. In the present article, we present the Gardony Map Drawing Analyzer (GMDA), an open-source software package for sketch map analysis. GMDA combines novel and established analysis techniques into a graphical user interface that permits rapid computational sketch map analysis. GMDA calculates GMDA-unique measures based on pairwise comparisons between landmarks, as well as bidimensional regression parameters (Friedman & Kohler, 2003), which together reflect sketch map quality at two levels: configural and individual landmark. The configural measures assess the overall landmark configuration and provide a whole-map analysis. Individual landmark measures, introduced in GMDA, assess individual landmark placement and indicate how individual landmarks contribute to the configural scores. Together, these measures provide a more complete psychometric picture of sketch map analysis, allowing for comparisons between sketch maps and between landmarks. The calculated measures reflect specific and cognitively relevant aspects of interlandmark spatial relationships, including distance and angular representation. GMDA supports complex environments (up to 48 landmarks) and two software modes that capture aspects of maps not addressed by existing techniques, such as landmark size and shape variation and interlandmark containment relationships. We describe the software and its operation and present a formal specification of calculation procedures for its unique measures. We then validate the software by demonstrating the capabilities and reliability of its measures using simulation and experimental data. The most recent version of GMDA is available at www.aarongardony.com/tools/map-drawing-analyzer. C1 [Gardony, Aaron L.; Brunye, Tad T.] US Army, Natick Soldier Res Dev & Engn Ctr, Cognit Sci Team, Natick, MA 01760 USA. [Gardony, Aaron L.; Taylor, Holly A.; Brunye, Tad T.] Tufts Univ, Dept Psychol, 490 Boston Ave, Medford, MA 02155 USA. RP Gardony, AL (reprint author), Tufts Univ, Dept Psychol, 490 Boston Ave, Medford, MA 02155 USA. EM agardony@gmail.com NR 36 TC 5 Z9 5 U1 1 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1554-351X EI 1554-3528 J9 BEHAV RES METHODS JI Behav. Res. Methods PD MAR PY 2016 VL 48 IS 1 BP 151 EP 177 DI 10.3758/s13428-014-0556-x PG 27 WC Psychology, Mathematical; Psychology, Experimental SC Psychology GA DI6DC UT WOS:000373588400012 PM 25673320 ER PT J AU Seay, JF Sauer, SG Patel, T Roy, TC AF Seay, Joseph F. Sauer, Shane G. Patel, Tejash Roy, Tanja C. TI A history of low back pain affects pelvis and trunk coordination during a sustained manual materials handling task SO JOURNAL OF SPORT AND HEALTH SCIENCE LA English DT Article DE Lifting; Lowering; Occupational biomechanics; Relative phase; Relative phase variability ID DYNAMICAL-SYSTEMS APPROACH; RISK-FACTORS; WALKING; INJURY; VARIABILITY; WORKERS AB Purpose: The purpose of this study was to compare the coordination between the trunk and the pelvis during a sustained asymmetric repetitive lifting task between a group with a history of low back pain (LBP; HBP) and a group with no history of LBP (NBP). Methods: Volunteers lifted a 11-kg box from ankle height in front to a shelf 45 degrees off-center at waist height, and lowered it to the start position at 12 cycles/min for 10 min. Lifting side was alternated during the trial. Continuous relative phase was used to calculate coordination between the pelvis and trunk rotation at the beginning (Min 1), middle (Min 5), and end of the bout (Min 9). Results: While there were no main effects for group, a significant interaction between time and group indicated that, in the frontal plane, the NBP group coordination was more anti-phase toward the end of the bout, with no such differences for the HBP group. Analysis of sagittal-axial (bend and twist) coordination revealed the HBP group coordination was more in-phase at the end of the bout over the entire cycle and for the lifting phase alone, with no such differences for the NBP group. Conclusion: Differences between groups demonstrate residual consequences of LBP in an occupational scenario, even though the HBP group was pain-free for >6 months prior to data collection. More in-phase coordination in the HBP group may represent a coordination pattern analogous to "guarded gait" which has been observed in other studies, and may lend insight as to why these individuals are at increased risk for re-injury. (C) 2016 Production and hosting by Elsevier B.V. on behalf of Shanghai University of Sport. C1 [Seay, Joseph F.; Sauer, Shane G.; Roy, Tanja C.] US Army, Mil Performance Div, Environm Med Res Inst, Natick, MA 01760 USA. [Patel, Tejash] US Army, Biophys & Biomed Modelling Div, Environm Med Res Inst, Natick, MA 01760 USA. RP Seay, JF (reprint author), US Army, Mil Performance Div, Environm Med Res Inst, Natick, MA 01760 USA. EM joseph.f.seay.civ@mail.mil NR 36 TC 1 Z9 1 U1 4 U2 4 PU SHANGHAI UNIV SPORT PI SHANGHAI PA EDITORIAL BOARD, 650 QINGYUANHUAN RD, SHANGHAI, 200438, PEOPLES R CHINA SN 2095-2546 EI 2213-2961 J9 J SPORT HEALTH SCI JI J. Sport Health Sci. PD MAR PY 2016 VL 5 IS 1 BP 52 EP 60 DI 10.1016/j.jshs.2016.01.011 PG 9 WC Hospitality, Leisure, Sport & Tourism; Sport Sciences SC Social Sciences - Other Topics; Sport Sciences GA DI8AH UT WOS:000373722600007 ER PT J AU Ferguson, JB Lopez, HF Cho, K Kim, CS AF Ferguson, J. B. Lopez, Hugo F. Cho, Kyu Kim, Chang-Soo TI Temperature Effects on the Tensile Properties of Precipitation-Hardened Al-Mg-Cu-Si Alloys SO METALS LA English DT Article DE tensile properties; temperature effects; Al alloys; precipitation-hardened alloys; property modeling ID CASTING ALLOYS; HEAT-TREATMENT; ALUMINUM; MODEL; MICROSTRUCTURE; DEFORMATION; EVOLUTION; BEHAVIOR; STORAGE AB Because the mechanical performance of precipitation-hardened alloys can be significantly altered with temperature changes, understanding and predicting the effects of temperatures on various mechanical properties for these alloys are important. In the present work, an analytical model has been developed to predict the elastic modulus, the yield stress, the failure stress, and the failure strain taking into consideration the effect of temperatures for precipitation-hardenable Al-Mg-Cu-Si Alloys (Al-A319 alloys). In addition, other important mechanical properties of Al-A319 alloys including the strain hardening exponent, the strength coefficient, and the ductility parameter can be estimated using the current model. It is demonstrated that the prediction results based on the proposed model are in good agreement with those obtained experimentally in Al-A319 alloys in the as-cast condition and after W and T7 heat treatments. C1 [Ferguson, J. B.; Lopez, Hugo F.; Kim, Chang-Soo] Univ Wisconsin, Dept Mat Sci & Engn, Milwaukee, WI 53211 USA. [Cho, Kyu] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Kim, CS (reprint author), Univ Wisconsin, Dept Mat Sci & Engn, Milwaukee, WI 53211 USA. EM jbf2@uwm.edu; hlopez@uwm.edu; kyu.c.cho2.civ@mail.mil; kimcs@uwm.edu FU U.S. Army Research laboratory [W911NF-15-2-0005] FX This materials is based upon work supported by the U.S. Army Research laboratory under Cooperative Agreement No. W911NF-15-2-0005. The views, opinions, and conclusions made in this document are those of authors and should not be interpreted the official policies, either expressed or implied, of Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 16 TC 1 Z9 1 U1 8 U2 15 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 2075-4701 J9 METALS-BASEL JI Metals PD MAR PY 2016 VL 6 IS 3 DI 10.3390/met6030043 PG 12 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA DI6NR UT WOS:000373616800026 ER PT J AU Stoddard, DR Sebesta, JA Welder, MD Foster, AJ Rush, RM AF Stoddard, Douglas R. Sebesta, James A. Welder, Matthew D. Foster, Andrew J. Rush, Robert M. TI What Patients Really Want: Optimizing the Military Preoperative Evaluation Clinic SO MILITARY MEDICINE LA English DT Article ID WAITING-TIMES AB The idea of the preoperative anesthesia clinic as a means of examining and treating the patient so that he will arrive in the operating theater as strong and healthy as possible is well established in practice and literature. However, problems in clinic design and execution often result in high patient waiting times, decreased patient and staff satisfaction, decreased patient capacity, and high clinic costs. Although the details of clinic design, outcomes, and satisfaction have been extensively evaluated at civilian hospitals, we have not found corresponding literature addressing these issues specifically within military preoperative evaluation clinics. We find that changing to an appointment-based (versus walk-in) system and eliminating data collection step redundancies will likely result in lower wait times, higher satisfaction, lower per patient costs, and a more streamlined and resource-efficient structure. C1 [Stoddard, Douglas R.; Sebesta, James A.; Foster, Andrew J.; Rush, Robert M.] Madigan Army Med Ctr, 9040 Jackson Ave, Tacoma, WA 98431 USA. [Welder, Matthew D.] US Army Med Command, Off Surg Gen, 7700 Arlington Blvd, Falls Church, VA 22032 USA. RP Stoddard, DR (reprint author), Madigan Army Med Ctr, 9040 Jackson Ave, Tacoma, WA 98431 USA. NR 15 TC 1 Z9 1 U1 1 U2 4 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAR PY 2016 VL 181 IS 3 BP 236 EP 242 DI 10.7205/MILMED-D-15-00072 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA DI3NJ UT WOS:000373405100018 PM 26926748 ER PT J AU Sell, TC Abt, JP Nagai, T Deluzio, JB Lovalekar, M Wirt, MD Lephart, SM AF Sell, Timothy C. Abt, John P. Nagai, Takashi Deluzio, Jennifer B. Lovalekar, Mita Wirt, Michael D. Lephart, Scott M. TI The Eagle Tactical Athlete Program Reduces Musculoskeletal Injuries in the 101st Airborne Division (Air Assault) SO MILITARY MEDICINE LA English DT Article ID FITNESS OUTCOMES; MILITARY; ARMY; SURVEILLANCE; PERFORMANCE; SOLDIERS; SPORTS; HEALTH AB The Eagle Tactical Athlete Program (ETAP) was scientifically developed for the U.S. Army's 101st Airborne Division (Air Assault) to counter unintentional musculoskeletal injuries (MSIs). Purpose: To determine if ETAP would reduce unintentional MSIs in a group of 101st Airborne Division (Air Assault) Soldiers. Methods: ETAP-trained noncommissioned led physical training. 1,720 Soldiers were enrolled (N = 1,136 experimental group [EXP], N = 584 control group [CON]) with injuries tracked before and after initiation of ETAP. The International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes were analyzed and described the anatomic locations, anatomic sub-locations, onset, and injury types. McNemar tests compared the proportions of injured subjects within each group. Results: There was a significant reduction in the proportion of Soldiers with preventable MSIs in the EXP (pre: 213/1,136 (18.8%), post: 180/1,136 (15.8%), p = 0.041) but not in the CON. In addition, there was a significant reduction in stress fractures in the EXP (pre: 14/1,136 (1.2%), post: 5/1,136 (0.4%), p = 0.022) but no significant differences in the CON. Conclusion: The current analysis demonstrated that ETAP reduces preventable MSIs in garrison. The capability of ETAP to reduce injuries confirms the vital role of a scientifically designed training program on force readiness and health. C1 [Sell, Timothy C.; Abt, John P.; Nagai, Takashi; Deluzio, Jennifer B.; Lovalekar, Mita; Lephart, Scott M.] Univ Pittsburgh, Neuromuscular Res Lab, 3830 South Water St, Pittsburgh, PA 15203 USA. [Wirt, Michael D.] US Army, Inst Surg Res, 3698 Chambers Pass Bldg,3611 JBSA, Ft Sam Houston, TX 78234 USA. RP Sell, TC (reprint author), Univ Pittsburgh, Neuromuscular Res Lab, 3830 South Water St, Pittsburgh, PA 15203 USA. FU U.S. Army Medical Research and Materiel Command [W81XWH-06-2-0070/W81XWH-09-2-0095/W81XWH-11-2-0097] FX We would like to thank the Soldiers of the U.S Army's 101st Airborne Division (Air Assault). Their time and effort was essential to the success of the ETAP. Supported by the U.S. Army Medical Research and Materiel Command under Award No. W81XWH-06-2-0070/W81XWH-09-2-0095/W81XWH-11-2-0097. NR 23 TC 0 Z9 0 U1 6 U2 8 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAR PY 2016 VL 181 IS 3 BP 250 EP 257 DI 10.7205/MILMED-D-14-00674 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA DI3NJ UT WOS:000373405100020 PM 26926750 ER PT J AU Sharkey, JM Abraham, JH Clark, LL Rohrbeck, P Ludwig, SL Hu, Z Baird, CP AF Sharkey, Jessica M. Abraham, Joseph H. Clark, Leslie L. Rohrbeck, Patricia Ludwig, Sharon L. Hu, Zheng Baird, Coleen P. TI Postdeployment Respiratory Health Care Encounters Following Deployment to Kabul, Afghanistan: A Retrospective Cohort Study SO MILITARY MEDICINE LA English DT Article ID US MILITARY PERSONNEL; MEDICAL ENCOUNTERS; PARTICULATE MATTER; SOUTHWEST ASIA; SYMPTOMS; IRAQ; PREVALENCE; EXPOSURE; SOLDIERS; WARRIOR AB Inhalational hazards are numerous in operational environments. A retrospective cohort study was conducted to investigate associations between deployment to Kabul, Afghanistan and subsequent respiratory health among U.S. military personnel. The study population consisted of personnel who deployed to Kabul, select Operation Enduring Freedom locations, personnel stationed in the Republic of Korea, and U.S.-stationed personnel. Incidence rate ratios (IRRs) were estimated for respiratory symptoms, signs, and ill-defined conditions, asthma, and chronic obstructive pulmonary disease. A significantly elevated rate of symptoms, signs, and ill-defined conditions was observed among Kabul-deployed personnel compared to personnel deployed or stationed in Bagram (IRR 1.12; 95% confidence interval [CI], 1.05-1.19), Republic of Korea (IRR 1.20; 95% CI, 1.10-1.31), and the United States (IRR 1.52; 95% CI, 1.43-1.62). A statistically elevated rate of asthma was observed among personnel deployed to Kabul, relative to U.S.-stationed personnel (IRR 1.61; 95% CI, 1.22-2.12). Statistically significant rates were not observed for chronic obstructive pulmonary disease among Kabul-deployed personnel compared to other study groups. These findings suggest that deployment to Kabul is associated with an elevated risk of postdeployment respiratory symptoms and new-onset asthma. C1 [Sharkey, Jessica M.; Abraham, Joseph H.; Baird, Coleen P.] US Army, Publ Hlth Command, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. [Clark, Leslie L.; Rohrbeck, Patricia; Ludwig, Sharon L.; Hu, Zheng] Armed Forces Hlth Surveillance Ctr, 11800 Tech Rd, Silver Spring, MD 20910 USA. RP Sharkey, JM (reprint author), US Army, Publ Hlth Command, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. NR 27 TC 2 Z9 2 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAR PY 2016 VL 181 IS 3 BP 265 EP 271 DI 10.7205/MILMED-D-14-00690 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA DI3NJ UT WOS:000373405100022 PM 26926752 ER PT J AU Mitchell, TA Lauer, CL Aden, JK Edwards, KD Bailey, JA White, CE Blackbourne, LH Holcomb, JB AF Mitchell, Thomas A. Lauer, Cynthia L. Aden, James K. Edwards, Kurt D. Bailey, Jeffrey A. White, Christopher E. Blackbourne, Lorne H. Holcomb, John B. TI Short-Term Outcomes and Complications of Damage Control and Definitive Laparotomy in Deployed Combat Environments: 2002 to 2011 SO MILITARY MEDICINE LA English DT Article ID CONTROL SURGERY; MANAGEMENT; BATTLEFIELD; CASUALTIES; SURVIVAL; INJURY; TRAUMA; TIME AB Introduction: Damage control laparotomy (DCL) in an austere environment is an evolving surgical modality. Methods: A retrospective evaluation of all patients surviving 24 hours who underwent a laparotomy from 2002 to 2011 in Iraq and Afghanistan was performed. DCL was defined as a patient undergoing laparotomy at two distinct North American Treaty Organization (NATO) Role 2 or 3 medical treatment facilities (MTFs); a NATO Roles 2 and 3 MTFs, and/or having the International Classification of Diseases, 9th Revision, Clinical Modification procedure code 54.12, for reopening of recent laparotomy site. Definitive laparotomy (DL) was defined as patients undergoing one operative procedure at one NATO Role 2 or 3 MTF. Demographic data including injury severity scores, hematological transfusion, mortality, intraperitoneal or retroperitoneal operative interventions, and complications were compared. Results: DCL composed of 26.5% (n = 331) of all 1,248 laparotomies performed between March 2002 and September 2011. Total intra-abdominal, acute respiratory distress syndrome, and thromboembolic complications for DCL versus DL were 8.5% and 5.6% (p = 0.07), 2.1% and 0.8% (p = 0.06), and 1.5% and 0.7% (p = 0.17), respectively. Theater discharge mortality from DCL and DL were 1.5% (n = 5), and 1.4% (n = 13) (p = 0.90), respectively. Conclusions: In conclusion, excluding deaths with the first 24 hours, DCL and DL had comparable mortality and complication rates at NATO Roles 2 and 3 MTFs. C1 [Mitchell, Thomas A.; Lauer, Cynthia L.; Edwards, Kurt D.; White, Christopher E.; Blackbourne, Lorne H.] San Antonio Mil Med Ctr, Dept Gen Surg, 3551 Roger Brooke Dr, Jbsa Ft Sam Houston, TX 78234 USA. [Aden, James K.; Bailey, Jeffrey A.] US Army, Inst Surg Res, 3698 Chambers Pass STE B, Jbsa Ft Sam Houston, TX 78234 USA. [Holcomb, John B.] Univ Texas Hlth Sci Ctr Houston, Div Acute Care Surg, Dept Surg, 7000 Fannin St, Houston, TX 77030 USA. RP Mitchell, TA (reprint author), San Antonio Mil Med Ctr, Dept Gen Surg, 3551 Roger Brooke Dr, Jbsa Ft Sam Houston, TX 78234 USA. FU U.S. Military FX The authors acknowledge the Department of Defense Trauma Registry (DoDTR) and the Patient Administration Systems and Biostatistics Activity (PASBA) for providing data for this study. The authors would like to disclose that no external funds were used to finance this project, and the U.S. Military was solely responsible for funding this research. NR 15 TC 0 Z9 0 U1 0 U2 4 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAR PY 2016 VL 181 IS 3 BP 277 EP 282 DI 10.7205/MILMED-D-14-00726 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA DI3NJ UT WOS:000373405100024 PM 26926754 ER PT J AU Stacey, SK Novek, SJ Maddox, CL AF Stacey, Stephen K. Novek, Steven J. Maddox, Craig L. TI Pityriasis Rubra Pilaris in a 3-Year-Old Male SO MILITARY MEDICINE LA English DT Article AB A 3-year-old male presented with progressive pruritic red-orange plaques across most of his body with erythema, desquamation, and fissuring of the hands and feet. He was diagnosed with classic juvenile (type III) pityriasis rubra pilaris (PRP) and treated with oral isotretinoin for 6 months. His skin findings resolved quickly during the treatment period, with residual postinflammatory hypopigmentation resolving within a year. PRP is rare in pediatric patients and standard recommended treatment algorithms for this population are not currently available. Diagnostic and treatment guidelines for PRP are based almost exclusively on case reports or case series, most of which focus on adult patients. The presentation, evaluation, and management of PRP are discussed. C1 [Stacey, Stephen K.] 1-503 IN ABN,173D IBCT A,CMR 427 Box 2962, APO, AE 09630 USA. [Novek, Steven J.] US Army, Hlth Ctr Vicenza, CMR 427, APO, AE 09630 USA. [Maddox, Craig L.] US Army, Hlth Ctr Vicenza, Dept Clin Specialties & Dermatol Serv, CMR 427, APO, AE 09630 USA. RP Stacey, SK (reprint author), 1-503 IN ABN,173D IBCT A,CMR 427 Box 2962, APO, AE 09630 USA. NR 10 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAR PY 2016 VL 181 IS 3 BP E298 EP E301 DI 10.7205/MILMED-D-15-00316 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA DI3NJ UT WOS:000373405100002 PM 26926758 ER PT J AU Granz, CD Schindler, BJ Peterson, GW Whitten, JE AF Granz, Christopher D. Schindler, Bryan J. Peterson, Gregory W. Whitten, James E. TI A fiber optic, ultraviolet light-emitting diode-based, two wavelength fluorometer for monitoring reactive adsorption SO REVIEW OF SCIENTIFIC INSTRUMENTS LA English DT Article ID PHOTOLUMINESCENCE PROPERTIES; ZIRCONIUM HYDROXIDE; SURFACE-CHEMISTRY; SULFUR-DIOXIDE; REMOVAL; THIOL; FILMS AB Construction and use of an ultraviolet light-emitting diode-based fluorometer for measuring photoluminescence (PL) from powder samples with a fiber optic probe is described. Fluorescence at two wavelengths is detected by miniature photomultiplier tubes, each equipped with a different band pass filter, whose outputs are analyzed by a microprocessor. Photoluminescent metal oxides and hydroxides, and other semiconducting nanoparticles, often undergo changes in their emission spectra upon exposure to reactive gases, and the ratio of the PL intensities at two wavelengths is diagnostic of adsorption. Use of this instrument for reactive gas sensing and gas filtration applications is illustrated by measuring changes in the PL ratio for zirconium hydroxide and zinc oxide particles upon exposure to air containing low concentrations of sulfur dioxide. (C) 2016 AIP Publishing LLC. C1 [Granz, Christopher D.; Whitten, James E.] Univ Massachusetts, Dept Chem, Lowell, MA 01854 USA. [Schindler, Bryan J.] Leidos Inc, POB 68, Gunpowder, MD 21010 USA. [Peterson, Gregory W.] US Army Edgewood Chem & Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Whitten, JE (reprint author), Univ Massachusetts, Dept Chem, Lowell, MA 01854 USA. EM James_Whitten@uml.edu FU Army Research Office; Defense Threat Reduction Agency [BA07PRO105] FX The authors acknowledge support from the Army Research Office. This work was conducted under Defense Threat Reduction Agency, Project No. BA07PRO105. NR 22 TC 0 Z9 0 U1 5 U2 9 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0034-6748 EI 1089-7623 J9 REV SCI INSTRUM JI Rev. Sci. Instrum. PD MAR PY 2016 VL 87 IS 3 AR 035121 DI 10.1063/1.4944761 PG 7 WC Instruments & Instrumentation; Physics, Applied SC Instruments & Instrumentation; Physics GA DI7WS UT WOS:000373713300083 PM 27036833 ER PT J AU Baimukanova, G Miyazawa, B Potter, DR Muench, MO Bruhn, R Gibb, SL Spinella, PC Cap, AP Cohen, MJ Pati, S AF Baimukanova, Gyulnar Miyazawa, Byron Potter, Daniel R. Muench, Marcus O. Bruhn, Roberta Gibb, Stuart L. Spinella, Philip C. Cap, Andrew P. Cohen, Mitchell J. Pati, Shibani TI Platelets regulate vascular endothelial stability: assessing the storage lesion and donor variability of apheresis platelets SO TRANSFUSION LA English DT Article ID TRAUMATIC BRAIN-INJURY; FRESH-FROZEN PLASMA; LARGE ANIMAL-MODEL; 22 DEGREES C; HEMORRHAGIC-SHOCK; MOLECULAR-BASIS; RESUSCITATION; PERMEABILITY; TRANSFUSION; MAINTENANCE AB BACKGROUNDIn current blood banking practices, platelets (PLTs) are stored in plasma at 22 degrees C, with gentle agitation for up to 5 days. To date, the effects of storage and donor variability on PLT regulation of vascular integrity are not known. STUDY DESIGN AND METHODSIn this study, we examined the donor variability of leukoreduced fresh (Day 1) or stored (Day 5) PLTs on vascular endothelial barrier function in vitro and in vivo. In vitro, PLT effects on endothelial cell (EC) monolayer permeability were assessed by analyzing transendothelial electrical resistances (TEER). PLT aggregation, a measure of hemostatic potential, was analyzed by impedance aggregometry. In vivo, PLTs were investigated in a vascular endothelial growth factor A (VEGF-A)-induced vascular permeability model in NSG mice, and PLT circulation was measured by flow cytometry. RESULTSTreatment of endothelial monolayers with fresh Day 1 PLTs resulted in an increase in EC barrier resistance and decreased permeability in a dose-dependent manner. Subsequent treatment of EC monolayers with Day 5 PLTs demonstrated diminished vasculoprotective effects. Donor variability was noted in all measures of PLT function. Day 1 PLT donors were more variable in their effects on TEER than Day 5 PLTs. In mice, while all PLTs regardless of storage time demonstrated significant protection against VEGF-A-induced vascular leakage, Day 5 PLTs exhibited reduced protection when compared to Day 1 PLTs. Day 1 PLTs demonstrated significant donor variability against VEGF-A-challenged vascular leakage in vivo. Systemic circulating levels of Day 1 PLTs were higher than those of Day 5 PLTs CONCLUSIONSIn vitro and in vivo, Day 1 PLTs are protective in measures of vascular endothelial permeability. Donor variability is most prominent in Day 1 PLTs. A decrease in the protective effects is found with storage of the PLT units between Day 1 and Day 5 at 22 degrees C, thereby suggesting that Day 5 PLTs are diminished in their ability to attenuate vascular endothelial permeability. C1 [Baimukanova, Gyulnar; Potter, Daniel R.; Muench, Marcus O.; Bruhn, Roberta; Gibb, Stuart L.; Pati, Shibani] Blood Syst Res Inst, 270 Mason Ave, San Francisco, CA 94118 USA. [Miyazawa, Byron; Cohen, Mitchell J.] Univ Calif San Francisco, Dept Surg, San Francisco, CA USA. [Pati, Shibani] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA. [Spinella, Philip C.] Washington Univ, Sch Med, Dept Pediat, Div Crit Care Med, St Louis, MO 63110 USA. [Cap, Andrew P.] US Army, Inst Surg Res USAISR, Jbsa Ft Sam Houston, TX USA. RP Pati, S (reprint author), Blood Syst Res Inst, 270 Mason Ave, San Francisco, CA 94118 USA. EM spati@bloodsystems.org RI Muench, Marcus/C-5025-2009 OI Muench, Marcus/0000-0001-8946-6605 FU National Institutes of Health [P01 DK088760]; Blood Systems Research Institute FX This work was supported by grants from the National Institutes of Health, P01 DK088760 (to MM), and funding from Blood Systems Research Institute. NR 39 TC 2 Z9 2 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 EI 1537-2995 J9 TRANSFUSION JI Transfusion PD MAR PY 2016 VL 56 SU 1 SI SI BP S65 EP S75 DI 10.1111/trf.13532 PG 11 WC Hematology SC Hematology GA DI2YJ UT WOS:000373364800009 PM 27001364 ER PT J AU Baimukanova, G Miyazawa, B Potter, DR Gibb, SL Keating, S Danesh, A Beyer, A Dayter, Y Bruhn, R Muench, MO Cap, AP Norris, PJ Spinella, P Cohen, M Pati, S AF Baimukanova, Gyulnar Miyazawa, Byron Potter, Daniel R. Gibb, Stuart L. Keating, Sheila Danesh, Ali Beyer, Ashley Dayter, Yelena Bruhn, Roberta Muench, Marcus O. Cap, Andrew P. Norris, Philip J. Spinella, Philip Cohen, Mitchell Pati, Shibani TI The effects of 22 degrees C and 4 degrees C storage of platelets on vascular endothelial integrity and function SO TRANSFUSION LA English DT Article ID FRESH-FROZEN PLASMA; HEMORRHAGIC-SHOCK; P-SELECTIN; TEMPERATURE STORAGE; MOLECULAR-BASIS; TRAUMA PATIENTS; DEGREES-C; IN-VIVO; BLOOD; TRANSFUSION AB BACKGROUNDAlthough a majority of the studies conducted to date on platelet (PLT) storage have been focused on PLT hemostatic function, the effects of 4 degrees C PLTs on regulation of endothelial barrier permeability are still not known. In this study, we compared the effects of room temperature (22 degrees C) stored and (4 degrees C) stored PLTs on the regulation of vascular endothelial cell (EC) permeability in vitro and in vivo. STUDY DESIGN AND METHODSDay 1, Day 5, and Day 7 leukoreduced apheresis PLTs stored at 4 or 22 degrees C were studied in vitro and in vivo. In vitro, PLT effects on EC permeability and barrier function, adhesion, and impedance aggregometry were investigated. In vivo, using a mouse model of vascular leak, attenuation of vascular leak and circulating PLT numbers were measured. RESULTSTreatment of EC monolayers with Day 5 or Day 7 PLTs, stored at both 22 degrees C and 4 degrees C, resulted in similar decreases in EC permeability on average. However, analysis of individual samples revealed significant variation that was donor dependent. Additional in vitro measurements revealed a decrease in inflammatory mediators, nonspecific PLT-endothelial aggregation and attenuated loss of aggregation over time to TRAP, ASPI, ADP, and collagen with 4 degrees C storage. In mice, while 22 degrees C and 4 degrees C PLTs both demonstrated significant protection against vascular endothelial growth factor A (VEGF-A)-induced vascular leak 22 degrees C PLTs exhibited increased protection compared to 4 degrees C PLTs. Systemic circulating levels of 4 degrees C PLTs were decreased compared to 22 degrees C PLTs. CONCLUSIONSIn vitro, 4 degrees C-stored PLTs exhibit a greater capacity to inhibit EC permeability than 22 degrees C-stored PLTs. In vivo, 22 degrees C PLTs provide superior control of vascular leak induced by VEGF-A. This discrepancy may be due to increased clearance of 4 degrees C PLTs from the systemic circulation. C1 [Baimukanova, Gyulnar; Potter, Daniel R.; Gibb, Stuart L.; Keating, Sheila; Danesh, Ali; Beyer, Ashley; Dayter, Yelena; Bruhn, Roberta; Muench, Marcus O.; Norris, Philip J.; Pati, Shibani] Univ Calif San Francisco, Blood Syst Res Inst, San Francisco, CA 94143 USA. [Miyazawa, Byron; Cohen, Mitchell] Univ Calif San Francisco, Dept Surg, San Francisco, CA 94143 USA. [Cap, Andrew P.] US Army Inst Surg Res, Coagulat & Blood Res Program, Jbsa Ft Sam Houston, TX USA. [Danesh, Ali; Norris, Philip J.; Pati, Shibani] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA. [Spinella, Philip] Washington Univ, Dept Pediat, St Louis, MO 63130 USA. RP Pati, S (reprint author), Blood Syst Res Inst, 270 Masonic Ave, San Francisco, CA 94118 USA. EM spati@bloodsystems.org RI Muench, Marcus/C-5025-2009 OI Muench, Marcus/0000-0001-8946-6605 NR 65 TC 1 Z9 1 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 EI 1537-2995 J9 TRANSFUSION JI Transfusion PD MAR PY 2016 VL 56 SU 1 SI SI BP S52 EP S64 DI 10.1111/trf.13455 PG 13 WC Hematology SC Hematology GA DI2YJ UT WOS:000373364800008 PM 27001362 ER PT J AU Bynum, JA Meledeo, MA Getz, TM Rodriguez, AC Aden, JK Cap, AP Pidcoke, HF AF Bynum, James A. Meledeo, M. Adam Getz, Todd M. Rodriguez, Armando C. Aden, James K. Cap, Andrew P. Pidcoke, Heather F. TI Bioenergetic profiling of platelet mitochondria during storage: 4 degrees C storage extends platelet mitochondrial function and viability SO TRANSFUSION LA English DT Article ID CHILLED BLOOD-PLATELETS; HEMOSTATIC EFFECTIVENESS; VIABLE PLATELETS; COLD-STORAGE; WHOLE-BLOOD; AGGREGATION; TRANSFUSION; OXYGEN; RESPIRATION; REACTIVITY AB BACKGROUNDPlatelets (PLTs) are stored at room temperature (RT) to preserve in vivo circulation time, but PLT quality is degraded. The PLT storage lesion is mitigated by refrigeration, but questions remain regarding effects of cold storage (4 degrees C) on mitochondrial function. Mitochondrial reactive oxygen species (ROS) generation may adversely affect PLT function and viability during storage, and refrigeration may mitigate these effects. STUDY DESIGN AND METHODSPLTs were stored under two temperature conditions (RT, 20-24 degrees C; or 4 degrees C, 1-6 degrees C) and four storage durations (baseline [BL] and Days 3, 5, and 7). Mitochondrial respiration and maximal oxygen utilization were assessed with high-resolution respirometry. Mitochondrial ROS generation was assessed using a superoxide stain. Rotational thromboelastometry (ROTEM) was performed at BL and on Day 5 to assess PLT function. Collagen-induced PLT aggregation was measured by impedance aggregometry. RESULTSMitochondrial ROS in 4 degrees C-stored samples were lower compared to RT and retained a greater capacity to generate ROS after activation. Mitochondrial respiration and maximal mitochondrial utilization was conserved in PLTs stored at 4 degrees C. ROTEM data demonstrated that net maximum clot firmness was higher in 4 degrees C samples compared to RT and prevented fibrinolysis. The aggregation response to collagen was preserved in the 4 degrees C samples versus RT-stored PLTs. Aggregation impairment correlated well with attenuated mitochondrial respiration and elevated production of intracellular mitochondrial ROS in the RT PLTs. CONCLUSIONMitochondrial damage and ROS production may contribute to loss of PLT viability during storage, whereas cold storage is known to preserve PLT function. Here we demonstrate that 4 degrees C storage results in less oxidant stress and preserves mitochondrial function and potential compared to RT. C1 [Bynum, James A.; Meledeo, M. Adam; Getz, Todd M.; Rodriguez, Armando C.; Aden, James K.; Cap, Andrew P.; Pidcoke, Heather F.] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX 78234 USA. RP Pidcoke, HF (reprint author), US Army Inst Surg Res, Jbsa Ft Sam Houston, TX 78234 USA. EM Heather.Pidcoke@terumobct.com FU US Army Medical Research and Materiel Command FX This study was conducted under a protocol reviewed and approved by the US Army Medical Research and Materiel Command Institutional Review Board and in accordance with the approved protocol. Support was received from the US Army Medical Research and Materiel Command. The authors declare that they have no conflicts of interest relevant to this article. The opinions or assertions contained herein are the private views of the author and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense. NR 48 TC 4 Z9 4 U1 1 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 EI 1537-2995 J9 TRANSFUSION JI Transfusion PD MAR PY 2016 VL 56 SU 1 SI SI BP S76 EP S84 DI 10.1111/trf.13337 PG 9 WC Hematology SC Hematology GA DI2YJ UT WOS:000373364800010 PM 27001365 ER PT J AU Cap, AP Pidcoke, HF Keil, SD Staples, HM Anantpadma, M Carrion, R Davey, RA Frazer-Abel, A Taylor, AL Gonzales, R Patterson, JL Goodrich, RP AF Cap, Andrew P. Pidcoke, Heather F. Keil, Shawn D. Staples, Hilary M. Anantpadma, Manu Carrion, Ricardo, Jr. Davey, Robert A. Frazer-Abel, Ashley Taylor, Audra L. Gonzales, Richard Patterson, Jean L. Goodrich, Raymond P. TI Treatment of blood with a pathogen reduction technology using ultraviolet light and riboflavin inactivates Ebola virus in vitro SO TRANSFUSION LA English DT Article ID HERPES-SIMPLEX VIRUS; TRANSFUSION-TRANSMITTED MALARIA; NORMAL HUMAN-FIBROBLASTS; ENHANCED REACTIVATION; PHOTOCHEMICAL INACTIVATION; IRRADIATED ADENOVIRUS; DNA-DAMAGE; PLATELET; PLASMA; INFECTION AB BACKGROUNDTransfusion of plasma from recovered patients after Ebolavirus (EBOV) infection, typically called convalescent plasma, is an effective treatment for active disease available in endemic areas, but carries the risk of introducing other pathogens, including other strains of EBOV. A pathogen reduction technology using ultraviolet light and riboflavin (UV+RB) is effective against multiple enveloped, negative-sense, single-stranded RNA viruses that are similar in structure to EBOV. We hypothesized that UV+RB is effective against EBOV in blood products without activating complement or reducing protective immunoglobulin titers that are important for the treatment of Ebola virus disease (EVD). STUDY DESIGN AND METHODSFour in vitro experiments were conducted to evaluate effects of UV+RB on green fluorescent protein EBOV (EBOV-GFP), wild-type EBOV in serum, and whole blood, respectively, and on immunoglobulins and complement in plasma. Initial titers for Experiments 1 to 3 were 4.21 log GFP units/mL, 4.96 log infectious units/mL, and 4.23 log plaque-forming units/mL. Conditions tested in the first three experiments included the following: 1EBOV-GFP plus UV+RB; 2EBOV-GFP plus RB only; 3EBOV-GFP plus UV only; 4EBOV-GFP without RB or UV; 5virus-free control plus UV only; and 6virus-free control without RB or UV. RESULTSUV+RB reduced EBOV titers to nondetectable levels in both nonhuman primate serum (2.8- to 3.2-log reduction) and human whole blood (3.0-log reduction) without decreasing protective antibody titers in human plasma. CONCLUSIONOur in vitro results demonstrate that the UV+RB treatment efficiently reduces EBOV titers to below limits of detection in both serum and whole blood. In vivo testing to determine whether UV+RB can improve convalescent blood product safety is indicated. C1 [Cap, Andrew P.; Pidcoke, Heather F.] US Army Inst Surg Res, Coagulat & Blood Res, Jbsa Ft Sam Houston, TX USA. [Keil, Shawn D.; Gonzales, Richard; Goodrich, Raymond P.] Terumo BCT, Lakewood, CO USA. [Staples, Hilary M.; Anantpadma, Manu; Carrion, Ricardo, Jr.; Davey, Robert A.; Patterson, Jean L.] Texas Biomed Res Inst, Dept Virol & Immunol, San Antonio, TX USA. [Frazer-Abel, Ashley] Natl Jewish Lab, Complement Lab, Denver, CO USA. [Taylor, Audra L.; Gonzales, Richard] US Army Blood Program, Jbsa Ft Sam Houston, TX USA. RP Cap, AP (reprint author), US Army Inst Surg Res, Coagulat & Blood Res, San Antonio, TX 78234 USA. EM andrew.p.cap.mil@mail.mil FU NIH HHS [P51 OD011133] NR 37 TC 3 Z9 3 U1 3 U2 10 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 EI 1537-2995 J9 TRANSFUSION JI Transfusion PD MAR PY 2016 VL 56 SU 1 SI SI BP S6 EP S15 DI 10.1111/trf.13393 PG 10 WC Hematology SC Hematology GA DI2YJ UT WOS:000373364800002 PM 27001363 ER PT J AU Gonzales, R Taylor, AL Atkinson, AJ Malloy, WW Macdonald, VW Cap, AP AF Gonzales, Richard Taylor, Audra L. Atkinson, Andrew J. Malloy, Wilbur W. Macdonald, Victor W. Cap, Andrew P. TI US Army blood program: 2025 and beyond SO TRANSFUSION LA English DT Article ID PLATELETS; STORAGE; VOLUNTEERS; SURVIVAL; 22-C; 4-C AB In preparing to support the Army in 2025 and beyond, the Army Blood Program remains actively engaged with the research and advanced development of blood products and medical technology to improve blood safety and efficacy in conjunction with the US Army Medical Research and Materiel Command. National and International Blood Bank authorities have noted that the US Army research and development efforts in providing new blood products and improving blood safety operate on the cutting edge of technology and are transformational for the global blood industry. Over the past 14 years, the Army has transformed how blood support is provided and improved the survival rate of casualties. Almost every product or process developed by or for the military has found an application in treating civilian patients. Conflicts have many unwanted consequences; however, in times of conflict, one positive aspect is the identification of novel solutions to improve the safety and efficacy of the blood supply. C1 [Gonzales, Richard] Terumo BCT, Grants Management & Govt Sponsored Res, 10810 West Collins Ave, Lakewood, CO 80215 USA. [Gonzales, Richard; Taylor, Audra L.] US Army Blood Program, Jbsa Ft Sam Houston, TX USA. [Atkinson, Andrew J.; Macdonald, Victor W.] US Army Med Res & Mat Command, US Army Med Mat Dev Act, Ft Detrick, MD USA. [Malloy, Wilbur W.] US Army Med Res & Mat Command, US Army Med Mat Dev Act, Hemorrhage & Resuscitat Forward Surg Care Blood P, CDMRP, Ft Detrick, MD USA. [Cap, Andrew P.] US Army Inst Surg Res, Coagulat & Blood Res, Jbsa Ft Sam Houston, TX USA. RP Gonzales, R (reprint author), Terumo BCT, Grants Management & Govt Sponsored Res, 10810 West Collins Ave, Lakewood, CO 80215 USA. EM Richard.gonzales@teru-mobct.com NR 28 TC 0 Z9 0 U1 4 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 EI 1537-2995 J9 TRANSFUSION JI Transfusion PD MAR PY 2016 VL 56 SU 1 SI SI BP S85 EP S93 DI 10.1111/trf.13338 PG 9 WC Hematology SC Hematology GA DI2YJ UT WOS:000373364800011 PM 27001366 ER PT J AU Pusateri, AE Given, MB Macdonald, VW Homer, MJ AF Pusateri, Anthony E. Given, Michael B. Macdonald, Victor W. Homer, Mary J. TI Comprehensive US government program for dried plasma development SO TRANSFUSION LA English DT Article ID SINGLE-DONOR PLASMA; MASSIVE TRANSFUSION; COMBAT; MULTICENTER; OPERATIONS; MORTALITY; PRODUCT; QUALITY; RATIO; FIELD AB Transfusion of plasma early after severe injury has been associated with improved survival. There are significant logistic factors that limit the ability to deliver plasma where needed in austere environments, such as the battlefield or during a significant civilian emergency. While some countries have access to more logistically supportable dried plasma, there is no such product approved for use in the United States. There is a clear need for a Food and Drug Administration (FDA)-approved dried plasma for military and emergency-preparedness uses, as well as for civilian use in remote or austere settings. The Department of Defense (DoD) and Biomedical Advanced Research and Development Authority are sponsoring development of three dried plasma products, incorporating different technologic approaches and business models. At the same time, the DoD is sponsoring prospective, randomized clinical studies on the prehospital use of plasma. These efforts are part of a coordinated program to provide a dried plasma for military and civilian applications and to produce additional information on plasma use so that, by the time we have an FDA-approved dried plasma, we will better understand how to use it. C1 [Pusateri, Anthony E.] US Army Med Res & Mat Command, Ft Detrick, MD USA. [Given, Michael B.] Off Naval Res, Arlington, VA 22217 USA. [Macdonald, Victor W.] US Army Med Mat Command, US Army Med Mat Dev Act, Ft Detrick, MD USA. [Homer, Mary J.] US Dept Hlth & Human Serv, Biomed Adv Res & Dev Author, Off Assistant Secretary Preparedness & Response, Washington, DC USA. RP Pusateri, AE (reprint author), US Army Med Res & Mat Command, Combat Casualty Care Res Program, 504 Scott St,Bldg 722, Ft Detrick, MD 21702 USA. EM anthony.e.pusateri.civ@mail.mil NR 29 TC 1 Z9 1 U1 1 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 EI 1537-2995 J9 TRANSFUSION JI Transfusion PD MAR PY 2016 VL 56 SU 1 SI SI BP S16 EP S23 DI 10.1111/trf.13331 PG 8 WC Hematology SC Hematology GA DI2YJ UT WOS:000373364800003 PM 27001356 ER PT J AU Reisner, AT Edla, S Liu, JB Rubin, JT Thorsen, JE Kittell, E Smith, JB Yeh, DD Reifman, J AF Reisner, Andrew T. Edla, Shwetha Liu, Jianbo Rubin, John T. Thorsen, Jill E. Kittell, Erin Smith, Jason B. Yeh, Daniel D. Reifman, Jaques TI Muscle Oxygen Saturation Improves Diagnostic Association Between Initial Vital Signs and Major Hemorrhage: A Prospective Observational Study SO ACADEMIC EMERGENCY MEDICINE LA English DT Article ID TISSUE; TRANSFUSION; PREDICTS; TRAUMA AB ObjectivesDuring initial assessment of trauma patients, vital signs do not identify all patients with life-threatening hemorrhage. We hypothesized that a novel vital sign, muscle oxygen saturation (SmO2), could provide independent diagnostic information beyond routine vital signs for identification of hemorrhaging patients who require packed red blood cell (RBC) transfusion. MethodsThis was an observational study of adult trauma patients treated at a Level I trauma center. Study staff placed the CareGuide 1100 tissue oximeter (Reflectance Medical Inc., Westborough, MA), and we analyzed average values of SmO2, systolic blood pressure (sBP), pulse pressure (PP), and heart rate (HR) during 10 minutes of early emergency department evaluation. We excluded subjects without a full set of vital signs during the observation interval. The study outcome was hemorrhagic injury and RBC transfusion 3 units in 24 hours (24-hr RBC 3). To test the hypothesis that SmO2 added independent information beyond routine vital signs, we developed one logistic regression model with HR, sBP, and PP and one with SmO2 in addition to HR, sBP, and PP and compared their areas under receiver operating characteristic curves (ROC AUCs) using DeLong's test. ResultsWe enrolled 487 subjects; 23 received 24-hr RBC 3. Compared to the model without SmO2, the regression model with SmO2 had a significantly increased ROC AUC for the prediction of 3 units of 24-hr RBC volume, 0.85 (95% confidence interval [CI], 0.75-0.91) versus 0.77 (95% CI, 0.66-0.86; p < 0.05 per DeLong's test). Results were similar for ROC AUCs predicting patients (n = 11) receiving 24-hr RBC 9. ConclusionsSmO(2) significantly improved the diagnostic association between initial vital signs and hemorrhagic injury with blood transfusion. This parameter may enhance the early identification of patients who require blood products for life-threatening hemorrhage. C1 [Reisner, Andrew T.; Rubin, John T.; Thorsen, Jill E.; Kittell, Erin] Massachusetts Gen Hosp, Dept Emergency Med, Boston, MA 02114 USA. [Edla, Shwetha; Liu, Jianbo; Smith, Jason B.; Reifman, Jaques] US Army Med Res & Mat Command, Dept Def Biotechnol, High Performance Comp Software Applicat Inst, Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA. [Yeh, Daniel D.] Massachusetts Gen Hosp, Dept Surg, Boston, MA 02114 USA. [Smith, Jason B.] OMNITEC Solut Inc, Natl Inst Mental Hlth Data Arch, Bethesda, MD USA. RP Reifman, J (reprint author), US Army Med Res & Mat Command, Dept Def Biotechnol, High Performance Comp Software Applicat Inst, Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA. EM jaques.reifman.civ@mail.mil FU Combat Casualty Care Research Area Directorate of the U.S. Army Medical Research and Materiel Command, Fort Detrick, MD FX This work was supported by the Combat Casualty Care Research Area Directorate of the U.S. Army Medical Research and Materiel Command, Fort Detrick, MD. The study sponsors did not have any role in the study design, data collection, analysis and interpretation of data, report writing, or decision to submit the article for publication. The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U.S. Army or of the U.S. Department of Defense. This paper has been approved for public release with unlimited distribution. NR 10 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1069-6563 EI 1553-2712 J9 ACAD EMERG MED JI Acad. Emerg. Med. PD MAR PY 2016 VL 23 IS 3 BP 353 EP 357 DI 10.1111/acem.12899 PG 5 WC Emergency Medicine SC Emergency Medicine GA DH9HF UT WOS:000373106300016 PM 26743804 ER PT J AU McCreary, A Ghosh, R Amani, M Wang, J Duerloo, KAN Sharma, A Jarvis, K Reed, EJ Dongare, AM Banerjee, SK Terrones, M Namburu, RR Dubey, M AF McCreary, Amber Ghosh, Rudresh Amani, Matin Wang, Jin Duerloo, Karel-Alexander N. Sharma, Ankit Jarvis, Karalee Reed, Evan J. Dongare, Avinash M. Banerjee, Sanjay K. Terrones, Mauricio Namburu, Raju R. Dubey, Madan TI Effects of Uniaxial and Biaxial Strain on Few-Layered Terrace Structures of MoS2 Grown by Vapor Transport SO ACS NANO LA English DT Article DE molybdenum disulfide; strain engineering; Raman; photoluminescence; interlayer sliding; CVD; few-layer ID TRANSITION-METAL DICHALCOGENIDES; MONOLAYER MOLYBDENUM-DISULFIDE; FIELD-EFFECT TRANSISTORS; AUGMENTED-WAVE METHOD; RAMAN-SPECTROSCOPY; ATOMIC LAYERS; ELECTRONIC-PROPERTIES; MULTILAYER MOS2; ULTRATHIN MOS2; BILAYER MOS2 AB One of the most fascinating properties of molybdenum disulfide (MoS2) is its ability to be subjected to large amounts of strain without experiencing degradation. The potential of MoS2 mono- and few-layers in electronics, opto electronics, and flexible devices requires the fundamental understanding of their properties as a function of strain. While previous reports have studied mechanically exfoliated flakes, tensile strain experiments on chemical vapor deposition (CVD)-grown few-layered MoS2 have not been examined hitherto, although CVD is a state of the art synthesis technique with clear potential for scale-up processes. In this report, we used CVD-grown terrace MoS2 layers to study how the number and size of the layers affected the physical properties under uniaxial and biaxial tensile strain. Interestingly, we observed significant shifts in both the Raman in-plane mode (as high as -5.2 cm(-1)) and photoluminescence (PL) energy (as high as -88 meV) for the few-layered MoS2 under similar to 1.5% applied uniaxial tensile strain when compared to monolayers and few-layers of MoS2 studied previously. We also observed slippage between the layers which resulted in a hysteresis of the Raman and PL spectra during further applications of strain. Through DFT calculations, we contended that this random layer slippage was due to defects present in CVD-grown materials. This work demonstrates that CVD-grown few-layered MoS2 is a realistic, exciting material for tuning its properties under tensile strain. C1 [McCreary, Amber; Amani, Matin; Dubey, Madan] US Army, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. [McCreary, Amber; Namburu, Raju R.] US Army, Res Lab, Computat & Informat Sci Directorate, Aberdeen Proving Ground, MD 21005 USA. [McCreary, Amber; Terrones, Mauricio] Penn State Univ, Dept Phys, University Pk, PA 16802 USA. [McCreary, Amber; Terrones, Mauricio] Penn State Univ, Ctr Dimens & Layered Mat 2, University Pk, PA 16802 USA. [Terrones, Mauricio] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. [Terrones, Mauricio] Penn State Univ, Dept Chem, University Pk, PA 16802 USA. [Ghosh, Rudresh; Sharma, Ankit] Univ Texas Austin, Microelect Res Ctr, Austin, TX 78758 USA. [Jarvis, Karalee] Univ Texas Austin, Texas Mat Inst, Austin, TX 78758 USA. [Wang, Jin; Dongare, Avinash M.] Univ Connecticut, Dept Mat Sci & Engn, Storrs, CT 06269 USA. [Wang, Jin; Dongare, Avinash M.] Univ Connecticut, Inst Mat Sci, Storrs, CT 06269 USA. [Duerloo, Karel-Alexander N.; Reed, Evan J.] Stanford Univ, Dept Mat Sci & Engn, Stanford, CA 94305 USA. [Amani, Matin] Univ Calif Berkeley, Elect Engn & Comp Sci, Berkeley, CA 94720 USA. [Amani, Matin] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Mat Sci, Berkeley, CA 94720 USA. RP Dubey, M (reprint author), US Army, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA.; Terrones, M (reprint author), Penn State Univ, Dept Phys, University Pk, PA 16802 USA.; Terrones, M (reprint author), Penn State Univ, Ctr Dimens & Layered Mat 2, University Pk, PA 16802 USA.; Terrones, M (reprint author), Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA.; Terrones, M (reprint author), Penn State Univ, Dept Chem, University Pk, PA 16802 USA. EM mut11@psu.edu; madan.dubey.civ@mail.mil FU Army Research Laboratory [W911NF-14-2-0059]; U.S. Army Research Laboratory (ARL) Director's Strategic Initiative (DSI) program on interfaces in stacked 2D atomic layered materials; U.S. Army Research Office MURI [W911NF-11-1-0362]; Army Research Office under STTR [W911NF-14-P-0030] FX This research was sponsored by the Army Research Laboratory. A.M., MA, RN., and M.D. acknowledge the support of the U.S. Army Research Laboratory (ARL) Director's Strategic Initiative (DSI) program on interfaces in stacked 2D atomic layered materials. A.M. and M.T. acknowledge the support of the U.S. Army Research Office MURI (Grant No. W911NF-11-1-0362). R.G. and S.KB. thank the Army Research Office for partial support of this work under STTR Award No. W911NF-14-P-0030. J.W. and A.D. acknowledge that this research was accomplished under Cooperative Agreement No. W911NF-14-2-0059 with the Army Research Laboratory. A.M. thanks Zefang Wang from the Physics Department at The Pennsylvania State University for her help with the differential reflectance measurements. J.W. and A.D. acknowledge Professor Douglas E. Spearot for giving us the implemented parameters of Mo-S in LAMMPS. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 72 TC 4 Z9 4 U1 21 U2 63 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1936-0851 EI 1936-086X J9 ACS NANO JI ACS Nano PD MAR PY 2016 VL 10 IS 3 BP 3186 EP 3197 DI 10.1021/acsnano.5b04550 PG 12 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA DH5TR UT WOS:000372855400019 PM 26881920 ER PT J AU Ruzmetov, D Zhang, KH Stan, G Kalanyan, B Bhimanapati, GR Eichfeld, SM Burke, RA Shah, PB O'Regan, TP Crowne, FJ Birdwell, AG Robinson, JA Davydov, AV Ivanov, TG AF Ruzmetov, Dmitry Zhang, Kehao Stan, Gheorghe Kalanyan, Berc Bhimanapati, Ganesh R. Eichfeld, Sarah M. Burke, Robert A. Shah, Pankaj B. O'Regan, Terrance P. Crowne, Frank J. Birdwell, A. Glen Robinson, Joshua A. Davydov, Albert V. Ivanov, Tony G. TI Vertical 2D/3D Semiconductor Heterostructures Based on Epitaxial Molybdenum Disulfide and Gallium Nitride SO ACS NANO LA English DT Article DE 2D material heterostructures; transition metal dichalcogenides; MoS2; van der Waals epitaxy; GaN; conductive atomic force microscopy; vertical transport ID CHEMICAL-VAPOR-DEPOSITION; HEXAGONAL BORON-NITRIDE; SINGLE-LAYER MOS2; MONOLAYER MOS2; ATOMIC LAYERS; TRANSISTORS; GRAPHENE; GROWTH AB When designing semiconductor heterostructures, it is expected that epitaxial alignment will facilitate low-defect interfaces and efficient vertical transport. Here, we report lattice-matched epitaxial growth of molybdenum disulfide (MoS2) directly on gallium nitride (GaN), resulting in high-quality, unstrained, single-layer MoS2 with strict registry to the GaN lattice. These results present a promising path toward the implementation of high-performance electronic devices based on 2D/3D vertical heterostructures, where each of the 3D and 2D semiconductors is both a template for subsequent epitaxial growth and an active component of the device. The MoS2 monolayer triangles average 1 mu m along each side, with monolayer blankets (merged triangles) exhibiting properties similar to that of single-crystal MoS2 sheets. Photoluminescence, Raman, atomic force microscopy, and X-ray photoelectron spectroscopy analyses identified monolayer MoS2 with a prominent 20-fold enhancement of photoluminescence in the center regions larger triangles. The MoS2/GaN structures are shown to electrically conduct in the out-of-plane direction, confirming the potential of directly synthesized 2D/3D semiconductor heterostructures for vertical, current flow. Finally, we estimate a MoS2/GaN contact resistivity to be less than 4 Omega.cm(2) and current spreading in the MoS2 monolayer of approximately 1 mu m in diameter. C1 [Ruzmetov, Dmitry; Burke, Robert A.; Shah, Pankaj B.; O'Regan, Terrance P.; Crowne, Frank J.; Birdwell, A. Glen; Ivanov, Tony G.] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. [Zhang, Kehao; Bhimanapati, Ganesh R.; Eichfeld, Sarah M.; Robinson, Joshua A.] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. [Zhang, Kehao; Bhimanapati, Ganesh R.; Eichfeld, Sarah M.; Robinson, Joshua A.] Penn State Univ, Ctr Dimens & Layered Mat 2, University Pk, PA 16802 USA. [Ruzmetov, Dmitry; Stan, Gheorghe; Kalanyan, Berc; Davydov, Albert V.] Natl Inst Stand & Technol, Mat Measurement Lab, Gaithersburg, MD 20899 USA. RP Ruzmetov, D; Ivanov, TG (reprint author), US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.; Ruzmetov, D (reprint author), Natl Inst Stand & Technol, Mat Measurement Lab, Gaithersburg, MD 20899 USA. EM dmitry.a.ruzmetov.ctr@mail.mil; tony.g.ivanov.civ@mail.mil FU U.S. Army Research Laboratory (ARL) Director's Strategic Initiative (DSI); Material Genome Initiative; National Science Foundation [DMR-1453924] FX This work was supported by the U.S. Army Research Laboratory (ARL) Director's Strategic Initiative (DSI) program on understanding and exploiting the electronic interface in stacked 2D atomic layered materials. D.R. and A.V.D. acknowledge the support of Material Genome Initiative funding allocated to NIST. J.A.R. acknowledges support of the National Science Foundation under Grant No. DMR-1453924. The authors are grateful to Dr. Gavin Liu from NIST for performing the X-ray diffraction measurements on the GaN substrates. NR 37 TC 15 Z9 15 U1 39 U2 110 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1936-0851 EI 1936-086X J9 ACS NANO JI ACS Nano PD MAR PY 2016 VL 10 IS 3 BP 3580 EP 3588 DI 10.1021/acsnano.5b08008 PG 9 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA DH5TR UT WOS:000372855400061 PM 26866442 ER PT J AU Wierzbicki, TA Lee, IC Gupta, AK AF Wierzbicki, Teresa A. Lee, Ivan C. Gupta, Ashwani K. TI Recent advances in catalytic oxidation and reformation of jet fuels SO APPLIED ENERGY LA English DT Article DE Catalytic combustion and fuel reformation; JP-8; Surrogate fuel; Sulfur tolerance; Kinetic modeling; Hybrid combustion ID VOLATILE ORGANIC-COMPOUNDS; NOBLE-METAL CATALYSTS; RH-NI CATALYSTS; DIESEL-FUEL; HYDROGEN-PRODUCTION; LOW-TEMPERATURE; HIGHER HYDROCARBONS; PEROVSKITE CATALYSTS; LIQUID HYDROCARBONS; REFORMING CATALYSTS AB This paper provides a review of progress in catalytic conversion of JP-8 fuel and its surrogates made over the last decade. The effect of different types of catalyst and support materials, as well as different preparation methods, is discussed in detail. The derivation of kinetic models for computational studies is also examined. Particular attention is given to the development of sulfur tolerant catalysts and the mechanisms by which catalyst poisoning occurs, as this is an important obstacle to overcome for systems using sulfur-laden fuel. Suggestions for further research are offered. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Wierzbicki, Teresa A.; Gupta, Ashwani K.] Univ Maryland, Dept Mech Engn, 2181 Martin Hall,Campus Dr, College Pk, MD 20742 USA. [Wierzbicki, Teresa A.; Lee, Ivan C.] US Army Res Lab, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RP Gupta, AK (reprint author), Univ Maryland, Dept Mech Engn, 2181 Martin Hall,Campus Dr, College Pk, MD 20742 USA. EM twierz@umd.edu; ivan.c.lee2.civ@mail.mil; akgupta@umd.edu FU U.S. Army Research Laboratory FX Support provided to Teresa A. Wierzbicki by the U.S. Army Research Laboratory is gratefully acknowledged. NR 109 TC 3 Z9 3 U1 5 U2 10 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0306-2619 EI 1872-9118 J9 APPL ENERG JI Appl. Energy PD MAR 1 PY 2016 VL 165 BP 904 EP 918 DI 10.1016/j.apenergy.2015.12.057 PG 15 WC Energy & Fuels; Engineering, Chemical SC Energy & Fuels; Engineering GA DH3GV UT WOS:000372676400073 ER PT J AU DiPasquale, DM Muza, SR Gunn, AM Li, Z Zhang, Q Harris, NS Strangman, GE AF DiPasquale, Dana M. Muza, Stephen R. Gunn, Andrea M. Li, Zhi Zhang, Quan Harris, N. Stuart Strangman, Gary E. TI Evidence for cerebral edema, cerebral perfusion, and intracranial pressure elevations in acute mountain sickness SO BRAIN AND BEHAVIOR LA English DT Article DE Altitude; exercise; hemoglobin; hypobaria; hypoxia; illness; near-infrared spectroscopy; normobaric; optic nerve sheath ID NEAR-INFRARED SPECTROSCOPY; NERVE SHEATH DIAMETER; COUNTERPOINT HYPOBARIC HYPOXIA; TRAUMATIC BRAIN-INJURY; NORMOBARIC HYPOXIA; HIGH-ALTITUDE; TERRESTRIAL ALTITUDE; DIFFERENT RESPONSES; EXPOSURE; HEMATOMAS AB IntroductionWe hypothesized that cerebral alterations in edema, perfusion, and/or intracranial pressure (ICP) are related to the development of acute mountain sickness (AMS). MethodsTo vary AMS, we manipulated ambient oxygen, barometric pressure, and exercise duration. Thirty-six subjects were tested before, during and after 8 h exposures in (1) normobaric normoxia (NN; 300m elevation equivalent); (2) normobaric hypoxia (NH; 4400m equivalent); and (3) hypobaric hypoxia (HH; 4400m equivalent). After a passive 15 min ascent, each subject participated in either 10 or 60min of cycling exercise at 50% of heart rate reserve. We measured tissue absorption and scattering via radio-frequency near-infrared spectroscopy (NIRS), optic nerve sheath diameter (ONSD) via ultrasound, and AMS symptoms before, during, and after environmental exposures. ResultsWe observed significant increases in NIRS tissue scattering of 0.350.11cm(-1) (P=0.001) in subjects with AMS (i.e., AMS+), consistent with mildly increased cerebral edema. We also noted a small, but significant increase in total hemoglobin concentrations with AMS+, 3.2 +/- 0.8molL(-1) (P<0.0005), consistent with increased cerebral perfusion. No effect of exercise duration was found, nor did we detect differences between NH and HH. ONSD assays documented a small but significant increase in ONSD (0.11 +/- 0.02mm; P<0.0005) with AMS+, suggesting mildly elevated ICP, as well as further increased ONSD with longer exercise duration (P=0.005). ConclusionIn AMS+, we found evidence of cerebral edema, elevated cerebral perfusion, and elevated ICP. The observed changes were small but consistent with the reversible nature of AMS. C1 [DiPasquale, Dana M.; Gunn, Andrea M.; Li, Zhi; Zhang, Quan; Strangman, Gary E.] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Psychiat, 149 13th St, Charlestown, MA 02129 USA. [Muza, Stephen R.] US Army Res Inst Environm Med, Environm Med & Mil Performance Div, Natick, MA USA. [Zhang, Quan; Strangman, Gary E.] Baylor Coll Med, Ctr Space Med, Houston, TX 77030 USA. [Harris, N. Stuart] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Emergency Med,Div Wilderness Med, Boston, MA 02129 USA. RP DiPasquale, DM (reprint author), Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Psychiat, 149 13th St, Charlestown, MA 02129 USA. EM dipasquale.dana@gmail.com FU DOD CDMRP program [W81-XWH1020199] FX We gratefully acknowledge the support of the DOD CDMRP program and grant W81-XWH1020199. NR 57 TC 3 Z9 3 U1 3 U2 8 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 2162-3279 J9 BRAIN BEHAV JI Brain Behav. PD MAR PY 2016 VL 6 IS 3 AR e00437 DI 10.1002/brb3.437 PG 10 WC Behavioral Sciences; Neurosciences SC Behavioral Sciences; Neurosciences & Neurology GA DH9TG UT WOS:000373138200007 PM 27099800 ER PT J AU Li, C Tian, R Porter, W Hammond, Z Strachan-Olson, D Kooker, AW Olivas, J Kessens, CC Jayaram, K Fearing, RS Full, RJ AF Li, C. Tian, R. Porter, W. Hammond, Z. Strachan-Olson, D. Kooker, A. W. Olivas, J. Kessens, C. C. Jayaram, K. Fearing, R. S. Full, R. J. TI Cockroach-inspired self-righting robots SO INTEGRATIVE AND COMPARATIVE BIOLOGY LA English DT Meeting Abstract CT Annual Meeting of the Society-for-Integrative-and-Comparative-Biology (SICB) CY JAN 03-07, 2016 CL Portland, OR SP Soc Integrat & Comparat Biol C1 Univ Calif Berkeley, Berkeley, CA 94720 USA. Army Res Lab, Adelphi, MD USA. EM chen.li@berkeley.edu NR 0 TC 0 Z9 0 U1 4 U2 4 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1540-7063 EI 1557-7023 J9 INTEGR COMP BIOL JI Integr. Comp. Biol. PD MAR PY 2016 VL 56 SU 1 MA P3.108 BP E323 EP E323 PG 1 WC Zoology SC Zoology GA DH0FJ UT WOS:000372457601650 ER PT J AU Levy, G Elkas, J Armstrong, AY Nieman, LK AF Levy, Gary Elkas, John Armstrong, Alicia Y. Nieman, Lynnette K. TI Endometrial Effects of Prolonged Therapy with the Selective Progesterone Receptor Modulator Ulipristal Acetate A Case Report SO JOURNAL OF REPRODUCTIVE MEDICINE LA English DT Article DE contraceptive agents; Ella norpregnadiene; endometrial hyperplasia; Esmya; fibroid; fibroids, uterine; leiomyoma; progesterone receptor; selective progesterone receptor modulator; ulipristal acetate ID RANDOMIZED CONTROLLED-TRIAL; PLACEBO-CONTROLLED TRIAL; UTERINE LEIOMYOMATA; MIFEPRISTONE RU486; ASOPRISNIL; FIBROIDS; WOMEN; MORPHOLOGY AB BACKGROUND: Prolonged exposure to a selective progesterone receptor modulator (ulipristal acetate) in a patient with benign metastasizing leiomyoma did not result in endometrial hyperplasia or neoplasia. CASE: A woman with history of benign metastasizing leiomyoma underwent medical treatment for 5 years with ulipristal acetate. Endometrial biopsies were performed at established intervals to monitor for intraepithelial neoplasia or progesterone receptor modulator associated endometrial changes (PAECs). The patient tolerated UPA therapy well; there was no evidence of hyperplasia or proliferative changes associated with progesterone-associated endometrial changes. CONCLUSION: In this case prolonged exposure to ulipristal acetate did not result in premalignant or malignant endometrial pathology. C1 Tripler Army Med Ctr, Dept Reprod Endocrinol & Infertil, Honolulu, HI 96859 USA. Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Reprod & Adult Endocrinol, NIH, Bethesda, MD USA. Northern Virginia Pelv Surg Associates PC, Annandale, VA USA. RP Levy, G (reprint author), Tripler Army Med Ctr, Reprod Med, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM garylevy1@gmail.com NR 23 TC 0 Z9 0 U1 1 U2 1 PU SCI PRINTERS & PUBL INC PI ST LOUIS PA PO DRAWER 12425 8342 OLIVE BLVD, ST LOUIS, MO 63132 USA SN 0024-7758 EI 1943-3565 J9 J REPROD MED JI J. Reprod. Med. PD MAR-APR PY 2016 VL 61 IS 3-4 BP 159 EP 162 PG 4 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA DH5VK UT WOS:000372860200011 PM 27172639 ER PT J AU Wang, YC Wu, XM Murray, C Hamblin, M Hooper, D Dai, TH AF Wang, Yucheng Wu, Ximing Murray, Clinton Hamblin, Michael Hooper, David Dai, Tianhong TI ANTIMICROBIAL BLUE LIGHT INACTIVATION OF GRAM-NEGATIVE PATHOGENS IN BIOFILMS SO LASERS IN SURGERY AND MEDICINE LA English DT Meeting Abstract CT Annual Conference of the American-Society-for-Laser-Medicine-and-Surgery CY MAR 30-APR 03, 2016 CL Boston, MA SP Amer Soc Laser Med & Surg C1 Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA. Brooke Army Med Ctr, Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0196-8092 EI 1096-9101 J9 LASER SURG MED JI Lasers Surg. Med. PD MAR PY 2016 VL 48 SU 27 MA 154 BP 52 EP 53 PG 2 WC Dermatology; Surgery SC Dermatology; Surgery GA DH9GS UT WOS:000373105000154 ER PT J AU Salyer, M AF Salyer, Matt TI And the Temple of Doom Town SO MASSACHUSETTS REVIEW LA English DT Article C1 [Salyer, Matt] US Mil Acad, West Point, NY USA. RP Salyer, M (reprint author), US Mil Acad, West Point, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU UNIV MASSACHUSETTS MASSACHUSETTS REVIEW PI AMHERST PA MEMORIAL HALL, AMHERST, MA 01003 USA SN 0025-4878 J9 MASS REV JI Mass. Rev. PD SPR PY 2016 VL 57 IS 1 BP 162 EP 175 PG 14 WC Literary Reviews SC Literature GA DI2HE UT WOS:000373315500027 ER PT J AU Hoare, J Duddu, R Damavarapu, R AF Hoare, John Duddu, Raja Damavarapu, Reddy TI A Safe Scalable Process for Synthesis of 4,6-Bis(nitroimino)-1,3,5-triazinan-2-one (DNAM) SO ORGANIC PROCESS RESEARCH & DEVELOPMENT LA English DT Article ID THERMAL-DECOMPOSITION; PROPELLANT COMPONENT; ENERGETIC SALTS; 1-METHYL-2,4,5-TRINITROIMIDAZOLE; HETEROCYCLES AB A modified and safe nitration process for production of 4,6-bis(nitroimino)-1,3,5-triazinan-2-one (DNAM), a high density high energy material, from melamine is described. Key to our strategy is to generate acetyl nitrate at 30-35 degrees C in the presence of the reactant melamine. The main advantage of our procedure is that it utilized a homogeneous reagent and a homogeneous reactant solution. This allowed control of the reaction exotherm much easier. The robustness of this process is successfully demonstrated by producing DNAM in multikilogram quantities using a 20 L reactor. C1 [Hoare, John; Duddu, Raja] US Army, Leidos, ARDEC, B3028, Picatinny Arsenal, NJ 07806 USA. [Damavarapu, Reddy] US Army, ARDEC, B3028, Picatinny Arsenal, NJ 07806 USA. RP Duddu, R (reprint author), US Army, Leidos, ARDEC, B3028, Picatinny Arsenal, NJ 07806 USA.; Damavarapu, R (reprint author), US Army, ARDEC, B3028, Picatinny Arsenal, NJ 07806 USA. EM raja.g.duddu.ctr@mail.mil FU ARDEC [W15QKN-09-9-1001 BRG-152] FX The authors gratefully acknowledge the support of ARDEC (Contract No: W15QKN-09-9-1001 BRG-152). We thank Dr. Damon Parish, Naval Research Laboratory, Washington, DC, for DNAM single crystal X-ray analysis. NR 42 TC 0 Z9 0 U1 2 U2 6 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1083-6160 EI 1520-586X J9 ORG PROCESS RES DEV JI Org. Process Res. Dev. PD MAR PY 2016 VL 20 IS 3 BP 683 EP 686 DI 10.1021/acs.oprd.6b00010 PG 4 WC Chemistry, Applied; Chemistry, Organic SC Chemistry GA DH3CK UT WOS:000372664900012 ER PT J AU Stuart, SC Gray, B Nevola, D Su, L Sachet, E Ulrich, M Dougherty, DB AF Stuart, S. C. Gray, B. Nevola, D. Su, L. Sachet, E. Ulrich, M. Dougherty, D. B. TI Magnetoelectric oxide films for spin manipulation in graphene SO PHYSICA STATUS SOLIDI-RAPID RESEARCH LETTERS LA English DT Article DE magnetoelectrics; spintronics; Cr2O3; films; graphene; spin field effect transistors; scanned probe microscopy ID RAY PHOTOELECTRON-SPECTROSCOPY; ROOM-TEMPERATURE; EXCHANGE BIAS AB The challenge of creating a graphene spin field effect transistor (spin-FET) demands a magnetic gate dielectric material whose magnetization can be switched electrically. We have grown films of Cr2O3 on top of graphite and graphene by pulsed laser deposition that shows this crucial functionality. We demonstrate that the Cr2O3 films are magnetoelectric by poling them in combined electric and magnetic fields and then using magnetic force microscopy to observe spontaneous surface domain structure as a function of poling field. In addition, we show that the electric field created by a conducting AFM tip can be used to write magnetic patterns in the film that demonstrate the kind of continuous magnetoelectric control needed for a prototype spin-FET. (C) 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim C1 [Stuart, S. C.; Gray, B.; Nevola, D.; Su, L.; Ulrich, M.; Dougherty, D. B.] N Carolina State Univ, Dept Phys, Raleigh, NC 27695 USA. [Sachet, E.] N Carolina State Univ, Dept Mat Sci & Engn, Box 7907, Raleigh, NC 27695 USA. [Ulrich, M.] Army Res Off, Durham, NC 27703 USA. [Stuart, S. C.] Aerosp Corp, Microelect Technol Dept, POB 92957, Los Angeles, CA 90009 USA. RP Dougherty, DB (reprint author), N Carolina State Univ, Dept Phys, Raleigh, NC 27695 USA. EM dbdoughe@ncsu.edu FU Army Research Office [W911NF-04-D-0003] FX We acknowledge useful discussions and technical assistance of Professor J. P. Maria. This work was supported by the Army Research Office under contract number W911NF-04-D-0003. NR 28 TC 1 Z9 1 U1 11 U2 20 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 1862-6254 EI 1862-6270 J9 PHYS STATUS SOLIDI-R JI Phys. Status Solidi-Rapid Res. Lett. PD MAR PY 2016 VL 10 IS 3 BP 242 EP 247 DI 10.1002/pssr.201510433 PG 6 WC Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Materials Science; Physics GA DH9MD UT WOS:000373119300007 ER PT J AU Korokhin, V Shkuratov, Y Kaydash, V Basilevsky, A Rohachova, L Velikodsky, Y Opanasenko, N Videen, G Stankevich, D Kaluhina, O AF Korokhin, Viktor Shkuratov, Yuriy Kaydash, Vadym Basilevsky, Alexander Rohachova, Larysa Velikodsky, Yuri Opanasenko, Nickolay Videen, Gorden Stankevich, Dmitry Kaluhina, Olena TI Characterization of of a photometric anomaly in lunar Mare Nubium SO PLANETARY AND SPACE SCIENCE LA English DT Article DE Moon; Surface; Mare Nubium; Photometry; Colorimetry; Mosaics; Phase function; Surface anomaly; Chemical composition; Lunar Reconnaissance Orbiter (LRO); Wide angle camera (WAC); Clementine UVVIS data ID CLEMENTINE UVVIS DATA; RECONNAISSANCE ORBITER; TIO2 CONCENTRATIONS; TITANIUM ABUNDANCE; SURFACE; MOON; SOIL; IRON; MINERALOGY; MATURITY AB A novel approach of constructing photometrically seamless mosaics of reflectance, color-ratios, and phase-curve slopes using LROC WAC images has been developed, which can be used to map the photometric parameters of the lunar surface. The approach takes into account both geometric corrections with data on local topography and photometric conjunctions using our simple photometric model. New mosaics obtained with the technique allow more reliable studies of structural and chemical characteristics of the lunar surface. This approach has been applied to analyze the photometric anomaly (21.6 S, 17.7 W, similar to 40 km in size) in Mare Nubium detected earlier with our Earth-based observations. For each point of the scene the parameters were calculated using the least-square method for several tens of source WAC images. Clementine mosaics also were used in the analysis, e.g., in order to estimate the parameter of maturity degree I-s/FeO. The anomaly has low FeO and TiO2 abundance and reveals a higher slope of the phase function than surroundings. Thermal data from LRO Diviner measurements do not show anomalies in this region. We consider this area as a shallow flooding of an elevated formation of highland composition, the material of which could have been excavated and mixed up with upper layers of the lunar surface through meteoroid impacts. The anomalous behavior of the phase function can be explained by the difference of surface structure in the anomaly and surrounding regions on the scale of less than several centimeters. This may be due to larger quantities of small fragments of rocks and clumps on the surface and/or the presence of agglomerates having open structure. (c) 2016 Elsevier Ltd. All rights reserved. C1 [Korokhin, Viktor; Shkuratov, Yuriy; Kaydash, Vadym; Rohachova, Larysa; Velikodsky, Yuri; Opanasenko, Nickolay; Stankevich, Dmitry; Kaluhina, Olena] Kharkiv VN Karazin Natl Univ, Inst Astron, 35 Sumskaya St, UA-61022 Kharkov, Ukraine. [Basilevsky, Alexander] RAS, VI Vernadskii Inst Geochem & Analyt Chem, 19 Kosygin St, Moscow 117975, Russia. [Velikodsky, Yuri] Natl Aviat Univ, Cosmonaut Komarov Ave 1, UA-03680 Kiev, Ukraine. [Videen, Gorden] Army Res Lab AMSRL CI EM, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Videen, Gorden] Space Sci Inst, 4750 Walnut St Suite 205, Boulder, CO 80301 USA. RP Korokhin, V (reprint author), Kharkiv VN Karazin Natl Univ, Inst Astron, 35 Sumskaya St, UA-61022 Kharkov, Ukraine. EM dslpp@astron.kharkov.ua OI Korokhin, Viktor/0000-0002-1911-3422; Velikodsky, Yuri/0000-0002-8219-128X; Rohachova, Larysa/0000-0002-8830-2390 FU NASA [NNX11AB25G] FX The authors gratefully acknowledge the research support from NASA Grant NNX11AB25G Lunar Advanced Science and Exploration Research (LASER) "Imaging photometric and polarimetric remote sensing of the Moon". The authors thank the SELENE(KAGUYA) TC team and the SELENE Data Archive for providing the SELENE(KAGUYA) data. SELENE is a Japanese mission developed and operated by JAXA. NR 73 TC 3 Z9 3 U1 3 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0032-0633 J9 PLANET SPACE SCI JI Planet Space Sci. PD MAR PY 2016 VL 122 BP 70 EP 87 DI 10.1016/j.pss.2016.01.011 PG 18 WC Astronomy & Astrophysics SC Astronomy & Astrophysics GA DH4RS UT WOS:000372773700008 ER PT J AU Nelson, N Asplund, CA AF Nelson, Nicole Asplund, Chad A. TI Exercise Testing: Who, When, and Why? SO PM&R LA English DT Review ID AMERICAN-HEART-ASSOCIATION; SCIENTIFIC STATEMENT; FUNCTIONAL-CAPACITY; CLINICAL CARDIOLOGY; CARDIOPULMONARY; REHABILITATION; PREVENTION; COMMITTEE; FAILURE; PROTOCOLS AB There are different modalities of exercise testing that can provide valuable information to physicians about patient and athlete fitness and cardiopulmonary status. Cardiopulmonary exercise testing (CPX) is a form of exercise testing that measures ventilatory and gas exchange, heart rate, electrocardiogram, and blood pressures to provide detailed information on the cardiovascular, pulmonary, and muscular systems. This testing allows an accurate quantification of functional capacity/measure of exercise tolerance, diagnosis of cardiopulmonary disease, disease-progression monitoring or response to intervention, and the prescription of exercise and training. CPX directly measures inhaled and exhaled ventilator gases to determine the maximal oxygen uptake, which reflects the body's maximal use of oxygen and defines the limits of the cardiopulmonary system. CPX is the ideal modality to evaluate causes of exertional fatigue and dyspnea, especially in complex cases in which the etiology could be cardiac, pulmonary, or deconditioning. Exercise tolerance has become an important outcome measure in patients with chronic obstructive pulmonary disease and congestive heart failure, as well as other chronic diseases, and is a well recognized predictor of mortality. Older athletes or those with underlying medical conditions could benefit from exercise testing for risk stratification and clearance to participate, as well as to help set their training zones and determine their functional limitations. C1 [Nelson, Nicole] Eisenhower Army Med Ctr, Dept Family Med, Ft Gordon, GA USA. [Asplund, Chad A.] Georgia So Univ, Dept Hlth & Kinesiol, Statesboro, GA 30458 USA. RP Asplund, CA (reprint author), Georgia So Univ, Dept Hlth & Kinesiol, Statesboro, GA 30458 USA. EM chad.asplund@gmail.com NR 36 TC 0 Z9 0 U1 4 U2 7 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1934-1482 EI 1934-1563 J9 PM&R JI PM&R PD MAR PY 2016 VL 8 IS 3 SU S BP S16 EP S23 DI 10.1016/j.pmrj.2015.10.019 PG 8 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA DH5UZ UT WOS:000372858900003 PM 26972264 ER PT J AU Bahder, TB AF Bahder, Thomas B. TI Transfer of spatial reference frame using singlet states and classical communication SO QUANTUM INFORMATION PROCESSING LA English DT Article DE Quantum algorithm; Reference frame transfer; Quantum orientation ID LUMINOUS ETHER; INTERFEROMETER; INFORMATION; ROTATION AB A simple protocol is described for transferring spatial orientation from Alice to Bob (two spatially separated observers). The two observers are assumed to share quantum singlet states and classical communication. The protocol assumes that Alice and Bob have complete free will (measurement independence) and is based on maximizing the Shannon mutual information between Alice and Bob's measurement outcomes. Repeated use of this protocol for each spatial axis of Alice allows transfer of a complete three-dimensional reference frame, up to inversion of each of the axes. The technological complexity of this protocol is similar to that needed for BB84 quantum key distribution and hence is much simpler to implement than recently proposed schemes for transmission of reference frames. A second protocol based on a Bayesian formalism is also discussed. C1 [Bahder, Thomas B.] US Army, RDECOM, Aviat & Missile Res Dev & Engn Ctr, Charles M Bowden Lab, Redstone Arsenal, AL 35898 USA. RP Bahder, TB (reprint author), US Army, RDECOM, Aviat & Missile Res Dev & Engn Ctr, Charles M Bowden Lab, Redstone Arsenal, AL 35898 USA. EM thomas.bahder@us.army.mil NR 41 TC 1 Z9 1 U1 2 U2 5 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1570-0755 EI 1573-1332 J9 QUANTUM INF PROCESS JI Quantum Inf. Process. PD MAR PY 2016 VL 15 IS 3 SI SI BP 1069 EP 1080 DI 10.1007/s11128-015-1212-9 PG 12 WC Physics, Multidisciplinary; Physics, Mathematical SC Physics GA DH6BX UT WOS:000372877100005 ER PT J AU Tracy, FT Walshire, LA Corcoran, MK AF Tracy, Fred T. Walshire, Lucas A. Corcoran, Maureen K. TI SENSITIVITY STUDY OF INPUT PARAMETERS FOR SEEPAGE FLOW SIMULATIONS USING PARALLEL COMPUTERS SO SCALABLE COMPUTING-PRACTICE AND EXPERIENCE LA English DT Article DE high performance computing; sensitivity analysis; finite element method; seepage flow modeling ID MODELS AB This paper describes a comprehensive sensitivity study that was performed using high performance parallel computers to understand the importance of input parameters to a transient partially saturated finite element seepage analysis for a levee with separate soil layers of sand, silty sand, and clay. Seepage flow in this paper refers to the type of flow of water that occurred through the failed levees in New Orleans, Louisiana, USA, as a result of Hurricane Katrina. The input parameters tested were saturated hydraulic conductivity, volumetric compressibility, residual moisture content, saturated moisture content, and two van Genuchten unsaturated flow parameters. The output data compiled to show the sensitivity of the input parameters were the simulation times (days) to achieve 25%, 50%, and 75% of the steady-state values of pore pressure at the toe of the levee beneath its blanket, flow rate through the landside flux section, and the level of saturation in the levee. The use of high performance parallel computers enabled the running of thousands of scenarios using different values for the input variables. A sensitivity investigation of this magnitude has not been previously performed. The results of this investigation indicated that the more sensitive soil parameters were the saturated hydraulic conductivity and the volumetric compressibility. The unsaturated van Genuchten parameters of the landside blanket had a larger than anticipated impact on the duration of time to achieve steady state. This practical example is an excellent success story for high performance computing in that running a given simulation for a couple of hours on thousands of processors in parallel replaced over a year's work using a PC. C1 [Tracy, Fred T.] Erdc, Informat Technol Lab, Vicksburg, MS USA. [Walshire, Lucas A.; Corcoran, Maureen K.] Erdc, GSL, Vicksburg, MS USA. RP Tracy, FT (reprint author), Erdc, Informat Technol Lab, Vicksburg, MS USA. NR 12 TC 0 Z9 0 U1 0 U2 0 PU UNIV VEST TIMISOARA, WEST UNIV TIMISOARA PI TIMISOARA PA BLVD VASILE PARVAN 4, TIMISOARA, TIMIS 300223, ROMANIA SN 1895-1767 J9 SCALABLE COMPUT-PRAC JI Scalable Comput.-Pract. Exp. PD MAR PY 2016 VL 17 IS 1 SI SI BP 47 EP 60 PG 14 WC Computer Science, Software Engineering SC Computer Science GA DH8SV UT WOS:000373067600005 ER PT J AU Dhall, R Seyler, K Li, Z Wickrarnaratne, D Neupane, MR Chatzakis, I Kosmowska, E Lake, RK Xu, XD Cronin, SB AF Dhall, Rohan Seyler, Kyle Li, Zhen Wickrarnaratne, Darshana Neupane, Mahesh R. Chatzakis, Ioannis Kosmowska, Ewa Lake, Roger K. Xu, Xiaodong Cronin, Stephen B. TI Strong Circularly Polarized Photoluminescence from Multilayer MoS2 Through Plasma Driven Direct-Gap Transition SO ACS PHOTONICS LA English DT Article DE intercalation; symmetry breaking transition metal dichalcogenides; circularly polarized photoluminescence ID VALLEY POLARIZATION; METAL DICHALCOGENIDES; LAYER MOS2; DISULFIDE; SPIN AB We report circularly polarized photoluminescence spectra taken from few layer MoS2 after treatment with a remotely generated oxygen plasma. Here, the oxygen plasma decouples the individual layers in MoS2 by perturbing the weak interlayer van der Waals forces without damaging the lattice structure. This decoupling causes a transition from an indirect to a direct band gap material, which causes a strong enhancement of the photoluminescence intensity. Furthermore, up to 80% circularly polarized photoluminescence is observed after plasma treatment of few layer MoS2 flakes, consistent with high spin polarization of the optically excited carriers. A strong degree of polarization continues up to room temperature, further indicating that the quality of the crystal does not suffer degradation due to the oxygen plasma exposure. Our results show that the oxygen plasma treatment not only engineers the van der Waals separation in these TMDC multilayers for enhanced PL quantum yields, but also produces high quality multilayer samples for strong circularly polarized emission, which offers the benefit of layer index as an additional degree of freedom, absent in monolayer MoS2. C1 [Dhall, Rohan; Li, Zhen; Chatzakis, Ioannis; Cronin, Stephen B.] Univ So Calif, Ming Hsieh Dept Elect Engn, Los Angeles, CA 90089 USA. [Seyler, Kyle; Xu, Xiaodong] Univ Washington, Dept Phys, Seattle, WA 98105 USA. [Wickrarnaratne, Darshana; Lake, Roger K.] Univ Calif Riverside, Dept Elect & Comp Engn, Riverside, CA 92521 USA. [Neupane, Mahesh R.] Us Army Res Lab, RDRL WMM G, Baltimore, MD 21001 USA. [Kosmowska, Ewa] XEI Sci, Redwood City, CA 94063 USA. RP Cronin, SB (reprint author), Univ So Calif, Ming Hsieh Dept Elect Engn, Los Angeles, CA 90089 USA. EM scronin@usc.edu OI Li, Zhen/0000-0003-0886-2994 FU DOE [DE-FG02-07ER46376]; National Science Foundation (NSF) [1307671]; FAME, one of six centers of STARnet, a Semiconductor Research Corporation program - MARCO; NSF [ACI-1053575]; DARPA; [DE-SC0012509] FX The experimental portion of this work carried out at USC was supported by DOE Award No. DE-FG02-07ER46376. The work at UW is supported by DE-SC0012509. The theoretical and computational work was supported by the National Science Foundation (NSF) Grant No. 1307671 and FAME, one of six centers of STARnet, a Semiconductor Research Corporation program sponsored by MARCO and DARPA. The computational work used the Extreme Science and Engineering Discovery Environment (XSEDE), which is supported by NSF, Grant No. ACI-1053575. NR 17 TC 1 Z9 1 U1 14 U2 35 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 2330-4022 J9 ACS PHOTONICS JI ACS Photonics PD MAR PY 2016 VL 3 IS 3 BP 310 EP 314 DI 10.1021/acsphotonics.5b00593 PG 5 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Optics; Physics, Applied; Physics, Condensed Matter SC Science & Technology - Other Topics; Materials Science; Optics; Physics GA DH0MY UT WOS:000372479500002 ER PT J AU Francis, M AF Francis, Michael TI Opinion: The NEPA and Major Water Resource Planning for the Future. What's the problem? Analysis Paralysis SO ENVIRONMENTAL PRACTICE LA English DT Editorial Material AB Federal water resources development planning and the associated environmental assessment processes have been very complex and expensive. Federal water resource agencies are reassessing approaches to planning, with the support of our leadership and legislators, which encourages National Environmental Policy Act (NEPA) practitioners to apply the Council on Environmental Quality guidance to improve NEPA and to work with regulating agencies to streamline efforts and provide reasonable levels of information adequate for risk informed decision making. C1 [Francis, Michael] US Army Corps Engineers, 201 North Third Ave, Walla Walla, WA 99362 USA. RP Francis, M (reprint author), US Army Corps Engineers, 201 North Third Ave, Walla Walla, WA 99362 USA. EM Michael.Francis@usace.army.mil NR 0 TC 0 Z9 0 U1 8 U2 10 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND SN 1466-0466 EI 1466-0474 J9 ENVIRON PRAC JI Environ. Pract. PD MAR PY 2016 VL 18 IS 1 BP 69 EP 71 DI 10.1017/S1466046615000423 PG 3 WC Environmental Sciences SC Environmental Sciences & Ecology GA DG8SF UT WOS:000372353200008 ER PT J AU Tate, R Conti, G Farmer, A Sobiesk, E AF Tate, Ryan Conti, Gregory Farmer, Alexander Sobiesk, Edward TI Evaluating Adversarial Interfaces An Automated Approach SO IEEE TECHNOLOGY AND SOCIETY MAGAZINE LA English DT Article C1 [Tate, Ryan] US Army, Cyber Sch, Ft Gordon, GA USA. [Conti, Gregory; Sobiesk, Edward] Army Cyber Inst, West Point, NY USA. [Farmer, Alexander] US Army, Intelligence & Secur Command, Ft George G Meade, MD USA. RP Tate, R (reprint author), US Army, Cyber Sch, Ft Gordon, GA USA. NR 26 TC 0 Z9 0 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0278-0097 EI 1937-416X J9 IEEE TECHNOL SOC MAG JI IEEE Technol. Soc. Mag. PD MAR PY 2016 VL 35 IS 1 BP 56 EP 68 DI 10.1109/MTS.2016.2518249 PG 13 WC Engineering, Electrical & Electronic SC Engineering GA DH2ZA UT WOS:000372654900013 ER PT J AU Stelmakh, V Chan, WR Ghebrebrhan, M Senkevich, J Joannopoulos, JD Soljacic, M Celanovic, I AF Stelmakh, Veronika Chan, Walker R. Ghebrebrhan, Michael Senkevich, Jay Joannopoulos, John D. Soljacic, Marin Celanovic, Ivan TI Sputtered Tantalum Photonic Crystal Coatings for High-Temperature Energy Conversion Applications SO IEEE TRANSACTIONS ON NANOTECHNOLOGY LA English DT Article DE Energy conversion; high-temperature coatings; photonic crystal; thermophotovoltaics ID THERMOPHOTOVOLTAICS; RADIATION AB Recent advances in photonic crystals have enabled high-efficiency thermophotovoltaic (TPV) energy conversion by allowing near-perfect spectral control. In this paper, photonic crystals fabricated in thick tantalum (Ta) coatings, sputtered onto a metallic substrate, were investigated as a potential replacement for photonic crystals fabricated in bulk refractory metal substrates in TPV applications. A 2-D photonic crystal was fabricated in a 30-mu m thick Ta sputtered coating using standard semiconductor processes as a proof-of-concept for a selective emitter/solar absorber. The reflectance of the fabricated photonic crystal coating was characterized before and after 1 h anneals at 700, 900, and 1100. degrees C, and after a 24 h anneal at 900. degrees C. To protect its surface during the anneals, a thin conformal hafnia (HfO2) layer was deposited by atomic layer deposition on the photonic crystal. The photonic crystal showed high spectral selectivity in good agreement with numerical simulations and sustained the anneals with minimal structural degradation or change in its optical properties. This study presents a promising alternative to bulk substrates as a relatively low-cost and easily integrated platform for nanostructured devices in high-temperature energy conversion systems. C1 [Stelmakh, Veronika; Chan, Walker R.; Senkevich, Jay; Joannopoulos, John D.; Soljacic, Marin; Celanovic, Ivan] MIT, Inst Soldier Nanotechnol, 77 Massachusetts Ave, Cambridge, MA 02139 USA. [Ghebrebrhan, Michael] US Army, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. [Joannopoulos, John D.; Soljacic, Marin] MIT, Dept Phys, Ctr Mat Sci & Engn, Cambridge, MA 02139 USA. [Joannopoulos, John D.; Soljacic, Marin] MIT, Elect Res Lab, Cambridge, MA 02139 USA. RP Stelmakh, V (reprint author), MIT, Inst Soldier Nanotechnol, 77 Massachusetts Ave, Cambridge, MA 02139 USA. EM stelmakh@mit.edu RI stelmakh, veronika/P-3098-2014 OI stelmakh, veronika/0000-0002-3099-1496 FU National Science Foundation (NSF) under NSF Award [ECS-0335765]; Solid-State Solar-Thermal Energy Conversion Center [S3TEC]; U.S. Department of Energy, Office of Science, Basic Energy Sciences [DE-SC0001299/DE-FG02-09ER46577]; U.S. Army Research Laboratory; U.S. Army Research Office through the Institute for Soldier Nanotechnologies [W911NF-13-D-0001] FX Fabrication was done in part at the Nanostructures Laboratory at MIT and at the Center for Nanoscale Systems at Harvard University, a Member of the National Nanotechnology Infrastructure Network, supported by the National Science Foundation (NSF) under NSF Award ECS-0335765. Fabrication was supported by the Solid-State Solar-Thermal Energy Conversion Center (S3TEC), an Energy Frontier Research Center supported by the U.S. Department of Energy, Office of Science, Basic Energy Sciences, under Award #DE-SC0001299/DE-FG02-09ER46577. This work was also supported by the U.S. Army Research Laboratory and the U.S. Army Research Office through the Institute for Soldier Nanotechnologies under Contract #W911NF-13-D-0001. The review of this paper was arranged by Associate Editor SIROMA Guest Editors. NR 28 TC 1 Z9 1 U1 3 U2 7 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1536-125X EI 1941-0085 J9 IEEE T NANOTECHNOL JI IEEE Trans. Nanotechnol. PD MAR PY 2016 VL 15 IS 2 BP 303 EP 309 DI 10.1109/TNANO.2016.2522423 PG 7 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Science & Technology - Other Topics; Materials Science; Physics GA DH2XX UT WOS:000372651800027 ER PT J AU Marathe, AR Lawhern, VJ Wu, DR Slayback, D Lance, BJ AF Marathe, Amar R. Lawhern, Vernon J. Wu, Dongrui Slayback, David Lance, Brent J. TI Improved Neural Signal Classification in a Rapid Serial Visual Presentation Task Using Active Learning SO IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING LA English DT Article DE Active learning; brain-computer interface; electroencephalography; rapid-serial visual presentation ID COUPLED COMPUTER VISION; FALSE DISCOVERY RATE; TARGET DETECTION; PERFORMANCE; RESPONSES; SEARCH; TRIAGE AB The application space for brain-computer interface (BCI) technologies is rapidly expanding with improvements in technology. However, most real-time BCIs require extensive individualized calibration prior to use, and systems often have to be recalibrated to account for changes in the neural signals due to a variety of factors including changes in human state, the surrounding environment, and task conditions. Novel approaches to reduce calibration time or effort will dramatically improve the usability of BCI systems. Active Learning (AL) is an iterative semi-supervised learning technique for learning in situations in which data may be abundant, but labels for the data are difficult or expensive to obtain. In this paper, we apply AL to a simulated BCI system for target identification using data from a rapid serial visual presentation (RSVP) paradigm to minimize the amount of training samples needed to initially calibrate a neural classifier. Our results show AL can produce similar overall classification accuracy with significantly less labeled data (in some cases less than 20%) when compared to alternative calibration approaches. In fact, AL classification performance matches performance of 10-fold cross-validation (CV) in over 70% of subjects when training with less than 50% of the data. To our knowledge, this is the first work to demonstrate the use of AL for offline electroencephalography (EEG) calibration in a simulated BCI paradigm. While AL itself is not often amenable for use in real-time systems, this work opens the door to alternative AL-like systems that are more amenable for BCI applications and thus enables future efforts for developing highly adaptive BCI systems. C1 [Marathe, Amar R.; Lawhern, Vernon J.; Slayback, David; Lance, Brent J.] US Army, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. [Lawhern, Vernon J.] Univ Texas San Antonio, Dept Comp Sci, San Antonio, TX 78249 USA. [Wu, Dongrui] Data Nova, Clifton Pk, NY 12065 USA. RP Marathe, AR; Lawhern, VJ (reprint author), US Army, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. EM amar.marathe@case.edu; vernon.lawhern@utsa.edu FU Office of the Secretary of Defense Autonomy Research Pilot Initiative program [MIPR DWAM31168]; U.S. Army Research Laboratory [W911NF-10-2-0022]; Oak Ridge Institute for Science and Engineering [MIPR 4LDATBP033] FX This project was supported by the Office of the Secretary of Defense Autonomy Research Pilot Initiative program MIPR DWAM31168, by the U.S. Army Research Laboratory, under Cooperative Agreement Number W911NF-10-2-0022 and through the Oak Ridge Institute for Science and Engineering under program MIPR 4LDATBP033. The views and the conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the U.S. Government. A. R. Marathe and V. J. Lawhern contributed equally to this work NR 58 TC 2 Z9 2 U1 4 U2 11 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1534-4320 EI 1558-0210 J9 IEEE T NEUR SYS REH JI IEEE Trans. Neural Syst. Rehabil. Eng. PD MAR PY 2016 VL 24 IS 3 BP 333 EP 343 DI 10.1109/TNSRE.2015.2502323 PG 11 WC Engineering, Biomedical; Rehabilitation SC Engineering; Rehabilitation GA DH1LU UT WOS:000372546400003 PM 26600162 ER PT J AU Cordova, CB Dembowski, SC Johnson, MR Combs, JJ Svoboda, SJ AF Cordova, Christopher B. Dembowski, Scott C. Johnson, Michael R. Combs, John J. Svoboda, Steven J. TI Osteoid Osteoma of the Femoral Neck in Athletes: Two Case Reports Differentiating From Femoral Neck Stress Injuries SO SPORTS HEALTH-A MULTIDISCIPLINARY APPROACH LA English DT Article DE osteoid osteoma; femoral neck stress fracture; athletes; bone tumor ID LOWER-EXTREMITY; BONE-SCINTIGRAPHY; IMAGING FINDINGS; FRACTURES; RECRUITS; CT AB The diagnosis of an intra-articular osteoid osteoma can be a challenging and lengthy process, with reports of delayed diagnosis of greater than 2 years. In the young, athletic patient with an atraumatic onset of groin pain, an overuse injury or muscle strain is the most likely etiology. However, an overuse injury of femoral neck stress fracture must be identified because of the potentially disastrous outcome of fracture completion. The similar clinical presentation of a femoral neck stress fracture and intra-articular osteoid osteoma of the femoral neck can further delay the diagnosis of the osteoid osteoma. In a patient with these differential diagnoses that do not improve with a period of nonweightbearing activity, a more intensive workup must ensue. The purpose of this case report is to describe the initial presentations, subsequent follow-up, and imaging findings leading to the diagnosis of osteoid osteoma as well as to differentiate an osteoid osteoma from femoral neck stress injuries. C1 [Cordova, Christopher B.; Combs, John J.] William Beaumont Army Med Ctr, Ft Bliss, TX USA. [Dembowski, Scott C.] Moncrief Army Community Hosp, Columbia, SC USA. [Johnson, Michael R.] Columbia Univ, Sch Med, New York, NY USA. [Svoboda, Steven J.] Keller Army Community Hosp, West Point, NY USA. RP Cordova, CB (reprint author), William Beaumont Army Med Ctr, 5005 North Piedras St, El Paso, TX 79920 USA. EM christopher.b.cordova.mil@mail.mil NR 25 TC 0 Z9 0 U1 0 U2 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1941-7381 EI 1941-0921 J9 SPORTS HEALTH JI Sports Health PD MAR-APR PY 2016 VL 8 IS 2 BP 172 EP 176 DI 10.1177/1941738115614263 PG 5 WC Sport Sciences SC Sport Sciences GA DH1EN UT WOS:000372527300011 PM 26517936 ER PT J AU van der Linden, WA Schulze, CJ Herbert, AS Krause, TB Wirchnianski, AA Dye, JM Chandran, K Bogyo, M AF van der Linden, Wouter A. Schulze, Christopher J. Herbert, Andrew S. Krause, Tyler B. Wirchnianski, Ariel A. Dye, John M. Chandran, Kartik Bogyo, Matthew TI Cysteine Cathepsin Inhibitors as Anti-Ebola Agents SO ACS INFECTIOUS DISEASES LA English DT Article DE filovirus; cathepsin inhibitor; Ebola virus; inhibition of host cell entry ID VIRUS ENTRY REQUIRES; NIEMANN-PICK C1; INFECTION; PROTEASES; DESIGN; PROBE; E-64 AB The recent Ebola virus outbreak in western Africa highlights the need for novel therapeutics that target Ebola virus and other filoviruses. Filoviruses require processing by host cell-derived cysteine cathepsins for productive infection. Here we report the generation of a focused library of cysteine cathepsin inhibitors and subsequent screening to identify compounds with potent activity against viral entry and replication. Our top compounds show highly potent and broad-spectrum activity against cysteine cathepsins and were able to effectively block entry of Ebola and Marburg viruses. These agents are promising leads for development as antifilovirus therapeutics. C1 [van der Linden, Wouter A.; Schulze, Christopher J.; Bogyo, Matthew] Stanford Univ, Sch Med, Dept Pathol, 300 Pasteur Dr, Stanford, CA 94305 USA. [Herbert, Andrew S.; Wirchnianski, Ariel A.; Dye, John M.] US Army, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Krause, Tyler B.; Chandran, Kartik] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA. RP Bogyo, M (reprint author), Stanford Univ, Sch Med, Dept Pathol, 300 Pasteur Dr, Stanford, CA 94305 USA.; Chandran, K (reprint author), Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA. EM kartik.chandran@einstein.yu.edu; mbogyo@stanford.edu FU National Institutes of Health [R01 EB005011, R01 AI088027]; Defense Threat Reduction Agency [CB3873]; Netherlands Organization for Scientific Research (NWO) FX We thank S. R. Lynch at the Stanford University Department of Chemistry NMR facility for assistance. This work was supported by National Institutes of Health Grants R01 EB005011 (to M.B.) and R01 AI088027 (to K.C.) and the Defense Threat Reduction Agency funding CB3873 (J.M.D.). W.A.v.d.L. was supported by a Rubicon fellowship from The Netherlands Organization for Scientific Research (NWO). NR 20 TC 3 Z9 3 U1 4 U2 6 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 2373-8227 J9 ACS INFECT DIS JI ACS Infect. Dis. PD MAR PY 2016 VL 2 IS 3 BP 173 EP 179 DI 10.1021/acsinfecdis.5b00130 PG 7 WC Chemistry, Medicinal; Infectious Diseases SC Pharmacology & Pharmacy; Infectious Diseases GA DG6RF UT WOS:000372213100002 PM 27347558 ER PT J AU Amata, E Xi, HL Colmenarejo, G Gonzalez-Diaz, R Cordon-Obras, C Berlanga, M Manzano, P Erath, J Roncal, NE Lee, PJ Leed, SE Rodriguez, A Sciotti, RJ Navarro, M Pollastri, MP AF Amata, Emanuele Xi, Hualin Colmenarejo, Gonzalo Gonzalez-Diaz, Rosario Cordon-Obras, Carlos Berlanga, Manuela Manzano, Pilar Erath, Jessey Roncal, Norma E. Lee, Patricia J. Leed, Susan E. Rodriguez, Ana Sciotti, Richard J. Navarro, Miguel Pollastri, Michael P. TI Identification of "Preferred" Human Kinase Inhibitors for Sleeping Sickness Lead Discovery. Are Some Kinases Better than Others for Inhibitor Repurposing? SO ACS INFECTIOUS DISEASES LA English DT Article DE preferred lead repurposing; Trypanosoma brucei; Trypanosoma cruzi; Leishmania major; Plasmodium falciparum; Published Kinase Inhibitor Set ID TRYPANOSOMA-BRUCEI; DRUG DISCOVERY; COMPOUND; POTENT AB A kinase-targeting cell-based high-throughput screen (HTS) against Trypanosoma brucei was recently reported, and this screening set included the Published Kinase Inhibitor Set (PKIS). From the PKIS was identified 53 compounds with pEC(50) >= 6. Utilizing the published data available for the PKIS, a statistical analysis of these active antiparasitic compounds was performed, allowing identification of a set of human kinases having inhibitors that show a high likelihood for blocking T. brucei cellular proliferation in vitro. This observation was confirmed by testing other established inhibitors of these human kinases and by mining past screening campaigns at GlaxoSmithKline. Overall, although the parasite targets of action are not known, inhibitors of this set of human kinases displayed an enhanced hit rate relative to a random kinase-targeting HTS campaign, suggesting that repurposing efforts should focus primarily on inhibitors of these specific human kinases. We therefore term this statistical analysis-driven approach "preferred lead repurposing". C1 [Amata, Emanuele; Pollastri, Michael P.] Northeastern Univ, Dept Chem & Chem Biol, 360 Huntington Ave, Boston, MA 02115 USA. [Xi, Hualin] Pfizer Inc, Computat Sci Ctr Emphasis, 610 Main St, Cambridge, MA 02140 USA. [Colmenarejo, Gonzalo; Berlanga, Manuela; Manzano, Pilar] GlaxoSmithKline, DDW, Tres Cantos Med Dev Campus, Tres Cantos 28760, Spain. [Colmenarejo, Gonzalo; Berlanga, Manuela; Manzano, Pilar] GlaxoSmithKline, CIB, Tres Cantos Med Dev Campus, Tres Cantos 28760, Spain. [Gonzalez-Diaz, Rosario; Cordon-Obras, Carlos; Navarro, Miguel] CSIC, Inst Parasitol & Biomed Lopez Neyra, Granada 18100, Spain. [Erath, Jessey; Rodriguez, Ana] NYU, Sch Med, Div Parasitol, Dept Microbiol, 341 East 25th St New York, New York, NY 10010 USA. [Rodriguez, Ana] NYU, Sch Med, Antiinfect Screening Core, New York, NY 10010 USA. [Roncal, Norma E.; Lee, Patricia J.; Leed, Susan E.; Sciotti, Richard J.] Walter Reed Army Inst Res, Expt Therapeut, 2460 Linden Lane, Silver Spring, MD 20910 USA. RP Pollastri, MP (reprint author), Northeastern Univ, Dept Chem & Chem Biol, 360 Huntington Ave, Boston, MA 02115 USA. EM m.pollastri@neu.edu OI Colmenarejo, Gonzalo/0000-0002-8249-4547; Rodriguez, Ana/0000-0002-0060-3405 FU Tres Cantos Open Lab Foundation [TC-007]; National Institutes of Health [R01AI082577, R01AI114685] FX We acknowledge funding from The Tres Cantos Open Lab Foundation (TC-007) and the National Institutes of Health (R01AI082577, R01AI114685). NR 16 TC 1 Z9 1 U1 2 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 2373-8227 J9 ACS INFECT DIS JI ACS Infect. Dis. PD MAR PY 2016 VL 2 IS 3 BP 180 EP 186 DI 10.1021/acsinfecdis.5b00136 PG 7 WC Chemistry, Medicinal; Infectious Diseases SC Pharmacology & Pharmacy; Infectious Diseases GA DG6RF UT WOS:000372213100003 PM 26998514 ER PT J AU Molohon, KJ Blair, PM Park, S Doroghazi, JR Maxson, T Hershfield, JR Flatt, KM Schroeder, NE Ha, T Mitchell, DA AF Molohon, Katie J. Blair, Patricia M. Park, Seongjin Doroghazi, James R. Maxson, Tucker Hershfield, Jeremy R. Flatt, Kristen M. Schroeder, Nathan E. Ha, Taekjip Mitchell, Douglas A. TI Plantazolicin Is an Ultranarrow-Spectrum Antibiotic That Targets the Bacillus anthracis Membrane SO ACS INFECTIOUS DISEASES LA English DT Article DE ribosomally synthesized and post-translationally modified natural product; antibiotic; mode of action; pathogen specific antibiotic; membrane depolarization; Bacillus anthracis; anthrax; thiazole; oxazole ID OPTICAL RECONSTRUCTION MICROSCOPY; CELL-WALL POLYSACCHARIDE; STAPHYLOCOCCUS-AUREUS; GAMMA-PHAGE; AMYLOLIQUEFACIENS FZB42; ESCHERICHIA-COLI; HIGH-SALINITY; IDENTIFICATION; SUBTILIS; DAPTOMYCIN AB Plantazolicin (PZN) is a ribosomally synthesized and post-translationally modified natural product from Bacillus methylotrophicus FZB42 and Bacillus pumilus. Extensive tailoring to 12 of the 14 amino acid residues in the mature natural product endows PZN with not only a rigid, polyheterocyclic structure, but also antibacterial activity. Here we report the remarkably discriminatory activity of PZN toward Bacillus anthracis, which rivals a previously described gamma (gamma) phage lysis assay in distinguishing B. anthracis from other members of the Bacillus cereus group. We evaluate the underlying cause of this selective activity by measuring the RNA expression profile of PZN-treated B. anthracis, which revealed significant up-regulation of genes within the cell envelope stress response. PZN depolarizes the B. anthracis membrane like other cell envelope-acting compounds but uniquely localizes to distinct foci within the envelope. Selection and whole-genome sequencing of PZN-resistant mutants of B. anthracis implicate a relationship between the action of PZN and cardiolipin (CL) within the membrane. Exogenous CL increases the potency of PZN in wild type B. anthracis and promotes the incorporation of fluorescently tagged PZN in the cell envelope. We propose that PZN localizes to and exacerbates structurally compromised regions of the bacterial membrane, which ultimately results in cell lysis. C1 [Molohon, Katie J.; Mitchell, Douglas A.] Univ Illinois, Dept Microbiol, Urbana, IL 61801 USA. [Molohon, Katie J.; Doroghazi, James R.; Mitchell, Douglas A.] Univ Illinois, Carl R Woese Inst Genom Biol, Urbana, IL 61801 USA. [Blair, Patricia M.; Maxson, Tucker; Ha, Taekjip; Mitchell, Douglas A.] Univ Illinois, Dept Chem, Urbana, IL 61801 USA. [Park, Seongjin; Ha, Taekjip] Univ Illinois, Dept Phys, Urbana, IL 61801 USA. [Park, Seongjin; Ha, Taekjip] Univ Illinois, Ctr Phys Living Cells, Urbana, IL 61801 USA. [Hershfield, Jeremy R.] US Army, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. [Flatt, Kristen M.; Schroeder, Nathan E.] Univ Illinois, Dept Crop Sci, Urbana, IL 61801 USA. [Ha, Taekjip] Howard Hughes Med Inst, Chevy Chase, MD 20815 USA. RP Mitchell, DA (reprint author), Univ Illinois, Carl R Woese Inst Genom Biol, 1206 West Gregory Dr,Room 3105, Urbana, IL 61801 USA. EM douglasm@illinois.edu OI Blair, Patricia/0000-0001-6360-8206 FU U.S. National Institutes of Health [1R01 GM097142]; Defense Threat Reduction Agency under USAMRIID [922141]; James R. Beck Graduate Research Fellowship; ACS Medicinal Chemistry Predoctoral Fellowship; Carle R. Woese Institute for Genomic Biology Fellows program FX This work was supported by the U.S. National Institutes of Health (1R01 GM097142 to DAM) and the Defense Threat Reduction Agency under USAMRIID (Project 922141). K.J.M., P.M.B., and J.R.D. were supported in part by a James R. Beck Graduate Research Fellowship, an ACS Medicinal Chemistry Predoctoral Fellowship, and the Carle R. Woese Institute for Genomic Biology Fellows program, respectively. The fenders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army. NR 79 TC 4 Z9 4 U1 5 U2 7 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 2373-8227 J9 ACS INFECT DIS JI ACS Infect. Dis. PD MAR PY 2016 VL 2 IS 3 BP 207 EP 220 DI 10.1021/acsinfecdis.5b00115 PG 14 WC Chemistry, Medicinal; Infectious Diseases SC Pharmacology & Pharmacy; Infectious Diseases GA DG6RF UT WOS:000372213100006 PM 27152321 ER PT J AU Ruhl, DS Tolisano, AM Swiss, TP Littlefield, PD Golden, JB AF Ruhl, Douglas S. Tolisano, Anthony M. Swiss, Tyler P. Littlefield, Philip D. Golden, J. Blake TI Ceruminous adenocarcinoma: An analysis of the Surveillance Epidemiology and End Results (SEER) database SO AMERICAN JOURNAL OF OTOLARYNGOLOGY LA English DT Article ID TUMORS AB Objectives: Ceruminous adenocarcinoma is a rare malignancy. However, due to the paucity of cases, this has been difficult to study. Using a population-based national database, patient demographics and survival trends were analyzed to further elucidate the management of this malignancy. Methods: The SEER database was queried for patients diagnosed with ceruminous adenocarcinoma between 1973 and 2010. Results: Twenty-two patients were identified in the database. The average age of diagnosis was between 60 and 64 years. All of the patients underwent surgical resection of the primary malignancy. Eight patients (36%) also had postoperative radiation. Conclusions: Ceruminous adenocarcinoma is uncommon but may not have as poor a prognosis as previously thought. Surgical resection alone appears to be a reasonable treatment option. Larger prospective studies are needed, but database analysis like this may provide clarity on the management of uncommon diseases. Published by Elsevier Inc. C1 [Ruhl, Douglas S.; Tolisano, Anthony M.; Swiss, Tyler P.; Littlefield, Philip D.; Golden, J. Blake] Tripler Army Med Ctr, Dept Otolaryngol Head & Neck Surg, Honolulu, HI 96859 USA. RP Ruhl, DS (reprint author), Tripler Army Med Ctr, Dept Otolaryngol Head & Neck Surg, Attn MCHK DSH, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM douglas.s.ruhl.mil@mail.mil NR 10 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0196-0709 EI 1532-818X J9 AM J OTOLARYNG JI Am. J. Otolaryngol. PD MAR-APR PY 2016 VL 37 IS 2 BP 70 EP 73 DI 10.1016/j.amjoto.2015.11.005 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA DG6RG UT WOS:000372213200002 PM 26954854 ER PT J AU Baylan, JM Chambers, JA McMullin, N Fletcher, JL Sinha, I Lundy, J King, BT Chan, RK AF Baylan, Joseph M. Chambers, J. Alan McMullin, Neil Fletcher, John L. Sinha, Indranil Lundy, Jonathan King, Booker T. Chan, Rodney K. TI Reverse posterior interosseous flap for defects of the dorsal ulnar wrist using previously burned and recently grafted skin SO BURNS LA English DT Article DE Hand burn; Posterior interosseous artery flap ID LOCAL FASCIOCUTANEOUS FLAPS; RECONSTRUCTION; HAND AB Background: In the severely burned patient, coverage of exposed bone in the dorsal ulnar wrist can be a difficult problem. This is especially challenging in patients with a high percentage total body surface area (TBSA) where donor flaps can be scarce. The use of previously burned and/or recently grafted skin as flaps is an option. It has been postulated that use of previously burned skin can result in higher rates of local or distant flap failures. The reverse posterior interosseous flap (PIF) is an axial flap, based on the retrograde posterior interosseous artery, to provide coverage of the hand. Here we describe utilization of the PIF, using previously burned and/or recently grafted skin for coverage of dorsal ulnar wrist defects. Methods: This is a case series of three patients, with extensive burns (range 35-83% TBSA), where defects of the dorsal ulnar wrist necessitated coverage. Each patient underwent PIF(s) utilizing previously burned and/or grafted skin, all within three months after their initial burn event. Results: Case 1: 28 year old male who suffered 35% TBSA via blast mechanism developed a chronic open wound over the dorsal ulnar wrist with exposed tendon. The patient successfully underwent a left PIF using previously grafted skin. Case 2: 23 year old male with 83% TBSA. Bilateral ulnar styloids were exposed. PIFs were performed bilaterally, using previously burned and recently grafted skin. Coverage was successful but received leech therapy post-operatively for venous congestion. Case 3: 37 year old male with 52% TBSA, with the most severe burns isolated to his bilateral upper extremities; the ulnar head was exposed. The posterior interroseous artery was explored and PIF was attempted, but there was no retrograde flow in the distal artery due to a deeper injury than previously recognized. The patient ultimately underwent a pedicled abdominal flap for coverage. Conclusions: Defects of the distal ulnar wrist after deep and extensive burns can be problematic. Use of the reverse PIF using previously burned skin, even those that has just been recently grafted is a viable option for this difficult patient population. However, it may not be possible in all patients. Vigilance and early intervention for post-operative venous congestion are important. (C) 2015 Elsevier Ltd and ISBI. All rights reserved. C1 [Baylan, Joseph M.] Scott & White Hosp Syst, Dept Surg, Temple, TX USA. [McMullin, Neil; Fletcher, John L.; Lundy, Jonathan; King, Booker T.; Chan, Rodney K.] US Army Inst Surg Res, Clin Div, 3650 Chambers Pass, Ft Sam Houston, TX 78234 USA. [McMullin, Neil; Fletcher, John L.; Lundy, Jonathan; King, Booker T.; Chan, Rodney K.] US Army Inst Surg Res, Burn Ctr, 3650 Chambers Pass, Ft Sam Houston, TX 78234 USA. [Chambers, J. Alan] Walter Reed Natl Mil Med Ctr, Washington, DC USA. [Sinha, Indranil] Brigham & Womens Hosp, Div Plast Surg, 75 Francis St, Boston, MA 02115 USA. RP Chan, RK (reprint author), US Army Inst Surg Res, Clin Div, 3650 Chambers Pass, Ft Sam Houston, TX 78234 USA.; Chan, RK (reprint author), US Army Inst Surg Res, Burn Ctr, 3650 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM rodney.k.chan@us.army.mil NR 17 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 EI 1879-1409 J9 BURNS JI Burns PD MAR PY 2016 VL 42 IS 2 BP E24 EP E30 DI 10.1016/j.burns.2015.06.020 PG 7 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA DG6FW UT WOS:000372179600004 PM 26652146 ER PT J AU Schlussel, AT Lustik, MB Johnson, EK Maykel, JA Champagne, BJ Damle, A Ross, HM Steele, SR AF Schlussel, A. T. Lustik, M. B. Johnson, E. K. Maykel, J. A. Champagne, B. J. Damle, A. Ross, H. M. Steele, S. R. TI A nationwide assessment comparing nonelective open with minimally invasive complex colorectal procedures SO COLORECTAL DISEASE LA English DT Article DE Nonelective; emergent; colorectal surgery; laparoscopy ID RISK-ADJUSTED ANALYSIS; OPEN COLECTOMY; LAPAROSCOPIC COLECTOMY; SURGICAL OUTCOMES; COLON-CANCER; ARTHROPLASTY; MANAGEMENT; MORTALITY; COLITIS; DISEASE AB AimThe use of minimally invasive colorectal surgery has increased greatly for both benign and malignant disease. Studies evaluating complex procedures have been largely limited to elective indications. We aimed to compare the outcome of a laparoscopic with an open transverse (TC) and total abdominal colectomy (TAC) in the nonelective setting. MethodComparative analysis was made using the Nationwide Inpatient Sample (2008-11) of patients undergoing a nonelective TC or TAC identified by ICD-9-CM procedure codes. The risk-adjusted 30-day outcome was assessed using regression modelling accounting for patient characteristics, comorbidity and surgical procedure. ResultsWe identified 7261 admissions including 818 laparoscopic and 6443 open procedures. The mean age of the population was 6517years and patients in the laparoscopic group were younger (56 +/- 20 vs 66 +/- 17years; P<0.05). The rate of a single complication was lower in the laparoscopic group (26% vs 38%; P<0.01), but this did not remain significant following a logistic regression analysis. Mortality was significantly lower in the laparoscopic group (3.1% vs 17%; P<0.01) and this remained true after adjusting for covariates (OR=0.62; P<0.05). Laparoscopic cases were associated with a shorter median length of stay (10 vs 13days; P<0.01) and hospital charge ($75758 vs $98833; P<0.01). ConclusionA nonelective laparoscopic TC or TAC is associated with an equivalent complication rate and lower mortality compared with an open operation. The results should encourage surgeons with the appropriate skills to consider a laparoscopic approach for nonelective pathology requiring a complex colectomy. C1 [Schlussel, A. T.] Brian Allgood Army Community Hosp, Dept Surg, Honolulu, HI USA. [Lustik, M. B.] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. [Johnson, E. K.; Steele, S. R.] Madigan Army Med Ctr, Dept Surg, Ft Lewis, WA USA. [Maykel, J. A.; Damle, A.] Univ Massachusetts, Mem Med Ctr, Div Colorectal Surg, Worcester, MA 01605 USA. [Champagne, B. J.] Univ Hosp Cleveland, Case Med Ctr, Div Colorectal Surg, Cleveland, OH 44106 USA. [Ross, H. M.] Temple Univ, Div Colorectal Surg, Philadelphia, PA 19122 USA. RP Steele, SR (reprint author), Madigan Army Med Ctr, Colon & Rectal Surg, 9606 Piperhill Dr SE, Olympia, WA 98513 USA. EM harkersteele@mac.com NR 19 TC 1 Z9 1 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1462-8910 EI 1463-1318 J9 COLORECTAL DIS JI Colorectal Dis. PD MAR PY 2016 VL 18 IS 3 BP 301 EP 311 DI 10.1111/codi.13113 PG 11 WC Gastroenterology & Hepatology; Surgery SC Gastroenterology & Hepatology; Surgery GA DG4IN UT WOS:000372036000015 PM 26362693 ER PT J AU Meisenheimer, ES Bevis, ZJ Tagawa, CW Glorioso, JE AF Meisenheimer, Erica S. Bevis, Zachary J. Tagawa, Chelsea W. Glorioso, John E. TI Drowning Injuries: An Update on Terminology, Environmental Factors, and Management SO CURRENT SPORTS MEDICINE REPORTS LA English DT Review ID RESPIRATORY-DISTRESS-SYNDROME; COLD-WATER IMMERSION; CARDIAC-ARREST; THERAPEUTIC HYPOTHERMIA; TEMPERATURE; SURFACTANT; PREVENTION; GUIDELINES; SURVIVORS; CHILDREN C1 [Meisenheimer, Erica S.; Bevis, Zachary J.; Tagawa, Chelsea W.; Glorioso, John E.] Tripler Army Med Ctr, Dept Family Med, 1 JarrettWhite Rd, Honolulu, HI 96859 USA. RP Glorioso, JE (reprint author), Tripler Army Med Ctr, Dept Family Med, 1 JarrettWhite Rd, Honolulu, HI 96859 USA. EM John.E.Glorioso.mil@mail.mil NR 24 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1537-890X EI 1537-8918 J9 CURR SPORT MED REP JI Curr. Sport. Med. Rep. PD MAR-APR PY 2016 VL 15 IS 2 BP 91 EP 93 DI 10.1249/JSR.0000000000000241 PG 3 WC Sport Sciences SC Sport Sciences GA DG2ML UT WOS:000371901200009 PM 26963016 ER PT J AU Bell, AE Falconi, A AF Bell, Adriane E. Falconi, Audrey TI Acupuncture for the Treatment of Sports Injuries in an Austere Environment SO CURRENT SPORTS MEDICINE REPORTS LA English DT Review ID LOW-BACK-PAIN; METAANALYSIS; BRAIN; OSTEOARTHRITIS; MANAGEMENT; KNEE; STIMULATION; CARE AB For sports injuries in an austere environment, narcotic pain medications are often unavailable or have limiting side effects like sedation or constipation. Meanwhile, nonsteroidal anti-inflammatory medications are frequently associated with gastrointestinal side effects and acetaminophen liver toxicity. A trained physician can rapidly use certain acupuncture techniques in an austere environment with potentially fewer side effects. Current medical literature notes low to moderate quality evidence for the use of acupuncture in lower back pain and osteoarthritis of the knee. There is emerging evidence for the use of acupuncture in traumatic brain injury. The U.S. military uses acupuncture in deployed settings to treat battlefield injuries with promising results. This article reviews the military's current use of acupuncture to treat injuries in a deployed setting and how this may translate to the care of a sports injury in an austere environment. C1 [Bell, Adriane E.; Falconi, Audrey] US Army, Dept Family Med, Residency Fac, Tripler Army Med Ctr,Med Corps, Honolulu, HI USA. RP Bell, AE (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM adriane.e.bell.mil@mail.mil NR 35 TC 0 Z9 0 U1 4 U2 10 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1537-890X EI 1537-8918 J9 CURR SPORT MED REP JI Curr. Sport. Med. Rep. PD MAR-APR PY 2016 VL 15 IS 2 BP 111 EP 115 DI 10.1249/JSR.0000000000000240 PG 5 WC Sport Sciences SC Sport Sciences GA DG2ML UT WOS:000371901200013 PM 26963020 ER PT J AU Falconi, A Flick, D Ferguson, J Glorioso, JE AF Falconi, Audrey Flick, David Ferguson, Jason Glorioso, John E. TI Spinal Cord Injuries in Wave-Riding Sports: The Influence of Environmental and Sport-Specific Factors SO CURRENT SPORTS MEDICINE REPORTS LA English DT Review ID SURFERS MYELOPATHY AB Spinal cord injury is a nonfatal, catastrophic consequence of wave-riding sports. With surfing at the core, a multitude of activities have evolved that attempt to harness the power of ocean waves. The unique qualities of each wave-riding sport, in combination with the environmental factors of the ocean, define the risk for potential injuries. As wave-riding sports have become more advanced, athletes continue to push physical barriers. Taller waves are attempted while incorporating aerial maneuvers, all without protective equipment. C1 [Falconi, Audrey; Flick, David; Ferguson, Jason; Glorioso, John E.] Tripler Army Med Ctr, Dept Family Med, Honolulu, HI 96859 USA. RP Falconi, A (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM Audrey.e.falconi.mil@mail.mil NR 19 TC 0 Z9 0 U1 1 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1537-890X EI 1537-8918 J9 CURR SPORT MED REP JI Curr. Sport. Med. Rep. PD MAR-APR PY 2016 VL 15 IS 2 BP 116 EP 120 DI 10.1249/JSR.0000000000000246 PG 5 WC Sport Sciences SC Sport Sciences GA DG2ML UT WOS:000371901200014 PM 26963021 ER PT J AU Houston, JR Dean, RG AF Houston, J. R. Dean, R. G. TI Erosional Impacts of Modified Inlets, Beach Encroachment, and Beach Nourishment on the East Coast of Florida SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE Beach; erosion; inlets; beach nourishment; shoreline change AB Most of the 21 inlets along the 588 km of sandy shoreline on the Florida east coast have been modified, primarily to improve navigation efficiency and safety. These modifications have usually caused significant downdrift shoreline erosion. Shoreline change data for the Florida east coast during the period from about 1869 to 1971, which was before widespread beach nourishment, are analyzed. Modified inlets during this period impacted about 25% of the shoreline and conservatively caused about 70% of the shoreline area recession and about 75-85% if counties are excluded that did not have modified inlets that caused net downdrift recession. During this same period of about 100 years, the remaining 75% of the shoreline advanced on average 46 m seaward. However, before Florida began regulating coastal construction, development often encroached on accreting shorelines, effectively masking much of the accretion. From about 1971 to 2007, a period of widespread beach nourishment, only about half of the nourishment sand was placed on eroding shorelines. About half was placed on shorelines that accreted or were stable from about 1869 to 1971 but where encroachment by development made the nourishment necessary. Over half of the recession caused by modified inlets still exists. The criteria used by the Florida Department of Environmental Protection to designate the erosional state of Florida east coast beaches was found to be problematic, since it currently designates 65% of this shoreline as eroding when only 20% eroded during the period of widespread beach nourishment from about 1971 to 2007. C1 [Houston, J. R.] US Army, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Dean, R. G.] Univ Florida, Dept Civil & Coastal Engn, Gainesville, FL 32611 USA. RP Houston, JR (reprint author), US Army, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM james.r.houston@usace.army.mil NR 43 TC 0 Z9 0 U1 1 U2 4 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0749-0208 EI 1551-5036 J9 J COASTAL RES JI J. Coast. Res. PD MAR PY 2016 VL 32 IS 2 BP 227 EP 240 DI 10.2112/JCOASTRES-D-15-00105.1 PG 14 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA DG4JK UT WOS:000372038300001 ER PT J AU Cooper, SA Huang, AA Raskin, RE Weng, HY Scott-Moncrieff, JC AF Cooper, S. A. Huang, A. A. Raskin, R. E. Weng, H. -Y. Scott-Moncrieff, J. C. TI Clinical data, clinicopathologic findings and outcome in dogs with amegakaryocytic thrombocytopenia and primary immune-mediated thrombocytopenia SO JOURNAL OF SMALL ANIMAL PRACTICE LA English DT Article ID BONE-MARROW; PURPURA AB OBJECTIVESThe aim of this study was to identify distinguishing characteristics between dogs diagnosed with amegakaryocytic thrombocytopenia and those diagnosed with presumed primary peripheral immune-mediated thrombocytopenia. Presenting clinical and clinicopathologic data and outcomes were compared between the two groups. METHODSRetrospective study performed on seven client-owned dogs diagnosed with amegakaryocytic thrombocytopenia and 34 client-owned dogs with primary peripheral immune-mediated thrombocytopenia. RESULTSAll dogs in the amegakaryocytic thrombocytopenia group were anaemic on presentation with a median haematocrit of 23% (range 94 to 36), while the primary peripheral immune-mediated thrombocytopoenia group had a median presenting haematocrit of 35% (range 10 to 53). Dogs with amegakaryocytic thrombocytopenia had a median of five (range 4 to 7) clinical signs of bleeding compared to a median of three (range 0 to 6) in the primary peripheral immune-mediated thrombocytopenia group with 86% (6 of 7) of amegakaryocytic thrombocytopenia dogs requiring a blood transfusion compared to 41% (14 of 34) of primary peripheral immune-mediated thrombocytopenia dogs. Six of the seven amegakaryocytic thrombocytopenia dogs did not survive to discharge, while only five of the 34 primary peripheral immune-mediated thrombocytopenia dogs did not survive to discharge. CLINICAL SIGNIFICANCEThe clinical presentation of dogs with amegakaryocytic thrombocytopenia and primary peripheral immune-mediated thrombocytopenia is similar, but dogs with amegakaryocytic thrombocytopenia had a more severe clinical course compared to primary peripheral immune-mediated thrombocytopenia dogs. The prognosis for dogs with amegakaryocytic thrombocytopenia is poor. C1 [Cooper, S. A.; Huang, A. A.; Scott-Moncrieff, J. C.] Purdue Univ, Coll Vet Med, Dept Vet Clin Sci, W Lafayette, IN 47907 USA. [Raskin, R. E.; Weng, H. -Y.] Purdue Univ, Coll Vet Med, Dept Comparat Pathobiol, W Lafayette, IN 47907 USA. [Cooper, S. A.] US Army Publ Hlth Command, Ft Bragg, NC 28307 USA. RP Scott-Moncrieff, JC (reprint author), Purdue Univ, Coll Vet Med, Dept Vet Clin Sci, W Lafayette, IN 47907 USA. EM scottmon@purdue.edu NR 14 TC 0 Z9 0 U1 4 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0022-4510 EI 1748-5827 J9 J SMALL ANIM PRACT JI J. Small Anim. Pract. PD MAR PY 2016 VL 57 IS 3 BP 142 EP 147 DI 10.1111/jsap.12441 PG 6 WC Veterinary Sciences SC Veterinary Sciences GA DG4DP UT WOS:000372021500005 PM 26799165 ER PT J AU Stewart, IJ Faulk, TI Sosnov, JA Clemens, MS Elterman, J Ross, JD Howard, JT Fang, R Zonies, DH Chung, KK AF Stewart, Ian J. Faulk, Tarra I. Sosnov, Jonathan A. Clemens, Michael S. Elterman, Joel Ross, James D. Howard, Jeffrey T. Fang, Raymond Zonies, David H. Chung, Kevin K. TI Rhabdomyolysis among critically ill combat casualties: Associations with acute kidney injury and mortality SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Rhabdomyolysis; acute kidney injury; trauma; war; mortality ID ACUTE-RENAL-FAILURE; TRAUMA PATIENTS; SERUM CREATININE; MARMARA EARTHQUAKE; RIFLE CRITERIA; CRUSH SYNDROME; RISK-FACTORS; CARE; MYOGLOBIN; SEVERITY AB BACKGROUND Rhabdomyolysis has been associated with poor outcomes in patients with traumatic injury, especially in the setting of acute kidney injury (AKI). However, rhabdomyolysis has not been systematically examined in a large cohort of combat casualties injured in the wars in Iraq and Afghanistan. METHODS We conducted a retrospective study of casualties injured during combat operations in Iraq and Afghanistan who were initially admitted to the intensive care unit from February 1, 2002, to February 1, 2011. Information on age, sex, Abbreviated Injury Scale (AIS) score, Injury Severity Score (ISS), mechanism of injury, shock index, creatine kinase, and serum creatinine were collected. These variables were examined via multivariate logistic and Cox regression analyses to determine factors independently associated with rhabdomyolysis, AKI, and death. RESULTS Of 6,011 admissions identified, a total of 2,109 patients met inclusion criteria and were included for analysis. Rhabdomyolysis, defined as creatine kinase greater than 5,000 U/L, was present in 656 subjects (31.1%). Risk factors for rhabdomyolysis identified on multivariable analysis included injuries to the abdomen and extremities, increased ISS, male sex, explosive mechanism of injury, and shock index greater than 0.9. After adjustment, patients with rhabdomyolysis had a greater than twofold increase in the odds of AKI. In the analysis for mortality, rhabdomyolysis was significantly associated with death until AKI was added, at which point it lost statistical significance. CONCLUSION We found that rhabdomyolysis is associated with the development of AKI in combat casualties. While rhabdomyolysis was strongly associated with mortality on the univariate model and in conjunction with both ISS and age, it was not associated with mortality after the inclusion of AKI. This suggests that the effect of rhabdomyolysis on mortality may be mediated by AKI. LEVEL OF EVIDENCE Prognostic and epidemiologic study, level III. C1 [Stewart, Ian J.; Faulk, Tarra I.] David Grant Med Ctr, Fairfield, CA USA. [Stewart, Ian J.; Sosnov, Jonathan A.; Elterman, Joel; Zonies, David H.; Chung, Kevin K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Fang, Raymond] US Air Force Ctr Sustainment Trauma & Readiness S, Baltimore, MD USA. [Sosnov, Jonathan A.; Clemens, Michael S.] San Antonio Mil Med Ctr, San Antonio, TX USA. [Ross, James D.] Wilford Hall Ambulatory Surg Ctr, 59th Med Wing, San Antonio, TX USA. [Howard, Jeffrey T.; Chung, Kevin K.] US Army Inst Surg Res, San Antonio, TX USA. [Elterman, Joel] Univ Cincinnati, Med Ctr, Cincinnati, OH 45267 USA. [Zonies, David H.] Oregon Hlth & Sci Univ, Portland, OR 97201 USA. RP Stewart, IJ (reprint author), David Grant Med Ctr, Clin Invest Facil, 101 Bodin Circle Travis AFB, Fairfield, CA 94535 USA. EM ian.stewart@us.af.mil NR 31 TC 2 Z9 2 U1 6 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD MAR PY 2016 VL 80 IS 3 BP 492 EP 498 DI 10.1097/TA.0000000000000933 PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA DF7XT UT WOS:000371571900028 PM 26670111 ER PT J AU Griep, MH Sandoz-Rosado, E Tumlin, TM Wetzel, E AF Griep, Mark H. Sandoz-Rosado, Emil Tumlin, Travis M. Wetzel, Eric TI Enhanced Graphene Mechanical Properties through Ultrasmooth Copper Growth Substrates SO NANO LETTERS LA English DT Article DE Graphene; breaking strength; electropolishing; 2D nanomaterial ID CHEMICAL-VAPOR-DEPOSITION; HEXAGONAL BORON-NITRIDE; GRAIN-BOUNDARIES; ELECTROPOLISHED COPPER; INTRINSIC STRENGTH; FILMS; TEMPERATURE; FOILS; CU; DYNAMICS AB The combination of extraordinary strength and stiffness in conjunction with exceptional electronic and thermal properties in lightweight two-dimensional materials has propelled graphene research toward a wide array of applications including flexible electronics and functional structural components. Tailoring graphene's properties toward a selected application requires precise control of the atomic layer growth process, transfer, and postprocessing procedures. To date, the mechanical properties of graphene are largely controlled through postprocess defect engineering techniques. In this work, we demonstrate the role of varied catalytic surface morphologies on the tailorability of subsequent graphene film quality and breaking strength, providing a mechanism to tailor the physical, electrical, and mechanical properties at the growth stage. A new surface planarization methodology that results in over a 99% reduction in Cu surface roughness allows for smoothness parameters beyond that reported to date in literature and clearly demonstrates the role of Cu smoothness toward a decrease in the formation of bilayer graphene defects, altered domain sizes, monolayer graphene sheet resistance values down to 120 Omega/rectangle and a 78% improvement in breaking strength. The combined electrical and mechanical enhancements achieved through this methodology allows for the direct growth of application quality flexible transparent conductive films with monolayer graphene. C1 [Griep, Mark H.; Sandoz-Rosado, Emil; Tumlin, Travis M.; Wetzel, Eric] US Army, Res Lab, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA. RP Griep, MH (reprint author), US Army, Res Lab, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA. EM mark.h.griep.civ@mail.mil FU U.S. Army Research Laboratory FX Funding for this work was provided by the U.S. Army Research Laboratory. This research was supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and U.S. ARL. NR 33 TC 8 Z9 8 U1 16 U2 50 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1530-6984 EI 1530-6992 J9 NANO LETT JI Nano Lett. PD MAR PY 2016 VL 16 IS 3 BP 1657 EP 1662 DI 10.1021/acs.nanolett.5b04531 PG 6 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA DG3CE UT WOS:000371946300022 PM 26882091 ER PT J AU Sheremet, A Davis, JR Tian, M Hanson, JL Hathaway, KK AF Sheremet, Alex Davis, Justin R. Tian, Miao Hanson, Jeffrey L. Hathaway, Kent K. TI TRIADS: A phase-resolving model for nonlinear shoaling of directional wave spectra SO OCEAN MODELLING LA English DT Article DE TRIADS; Directinal spectrum; Nonlinear; Hurricane Bill ID SURFACE GRAVITY-WAVES; LINEAR ENERGY TRANSFER; INFRAGRAVITY WAVES; SOLITARY WAVE; VARIABLE DEPTH; EVOLUTION; WATER; TRANSFORMATION; PROPAGATION; ESTIMATOR AB We investigate the performance of TRIADS, a numerical implementation of a phase-resolving, nonlinear, spectral model describing directional wave evolution in intermediate and shallow water. TRIADS simulations of shoaling waves generated by Hurricane Bill, 2009 are compared to directional spectral estimates based on observations collected at the Field Research Facility of the US Army Corps Of Engineers, at Duck, NC. Both the ability of the model to capture the processes essential to the nonlinear wave evolution, and the efficiency of the numerical implementations are analyzed and discussed. Published by Elsevier Ltd. C1 [Sheremet, Alex; Davis, Justin R.; Tian, Miao] Univ Florida, ESSIE, 365 Weil Hall, Gainesville, FL 32611 USA. [Hanson, Jeffrey L.; Hathaway, Kent K.] US Army Corps Engineers, Field Res Facil, Duck, NC USA. RP Sheremet, A (reprint author), Univ Florida, ESSIE, 365 Weil Hall, Gainesville, FL 32611 USA. EM alex.sheremet@essie.ufl.edu; justin.r.davis@essie.ufl.edu; mtian04.18@ufl.edu; Jeffrey.L.Hanson@usace.army.mil; mtian04.18@ufl.edu OI Davis, Justin/0000-0001-6407-5229 FU ONR [N00014-13-1-0620, N00014-10-1-0389, N00014-10-0805] FX This research was supported by ONR Grants N00014-13-1-0620, N00014-10-1-0389, and N00014-10-0805. NR 58 TC 1 Z9 1 U1 1 U2 5 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1463-5003 EI 1463-5011 J9 OCEAN MODEL JI Ocean Model. PD MAR PY 2016 VL 99 BP 60 EP 74 DI 10.1016/j.ocemod.2016.01.002 PG 15 WC Meteorology & Atmospheric Sciences; Oceanography SC Meteorology & Atmospheric Sciences; Oceanography GA DG0YT UT WOS:000371792800005 ER PT J AU Kenow, KP Benjamin, GL Schlagenhaft, TW Nissen, RA Stefanski, M Wege, GJ Jutila, SA Newton, TJ AF Kenow, K. P. Benjamin, G. L. Schlagenhaft, T. W. Nissen, R. A. Stefanski, M. Wege, G. J. Jutila, S. A. Newton, T. J. TI Process, Policy, and Implementation of Pool-Wide Drawdowns on the Upper Mississippi River: A Promising Approach for Ecological Restoration of Large Impounded Rivers SO RIVER RESEARCH AND APPLICATIONS LA English DT Article DE drawdown; navigation pool; restoration; upper Mississippi River; water level management ID WATER-LEVEL MANAGEMENT; VEGETATION; EXPOSURE AB The Upper Mississippi River (UMR) has been developed and subsequently managed for commercial navigation by the U.S. Army Corps of Engineers (USACE). The navigation pools created by a series of lock and dams initially provided a complex of aquatic habitats that supported a variety of fish and wildlife. However, biological productivity declined as the pools aged. The River Resources Forum, an advisory body to the St. Paul District of the USACE, established a multiagency Water Level Management Task Force (WLMTF) to evaluate the potential of water level management to improve ecological function and restore the distribution and abundance of fish and wildlife habitat. The WLMTF identified several water level management options and concluded that summer growing season drawdowns at the pool scale offered the greatest potential to provide habitat benefits over a large area. Here we summarize the process followed to plan and implement pool-wide drawdowns on the UMR, including involvement of stakeholders in decision making, addressing requirements to modify reservoir operating plans, development and evaluation of drawdown alternatives, pool selection, establishment of a monitoring plan, interagency coordination, and a public information campaign. Three pool-wide drawdowns were implemented within the St. Paul District and deemed successful in providing ecological benefits without adversely affecting commercial navigation and recreational use of the pools. Insights are provided based on more than 17years of experience in planning and implementing drawdowns on the UMR. Copyright (c) 2015 John Wiley & Sons, Ltd. C1 [Kenow, K. P.; Newton, T. J.] US Geol Survey, Upper Midwest Environm Sci Ctr, La Crosse, WI 54603 USA. [Benjamin, G. L.; Nissen, R. A.] Nature Conservancy, Great Rivers Partnership, La Crosse, WI 54601 USA. [Schlagenhaft, T. W.] Minnesota Dept Nat Resources, Lake City, MN 55041 USA. [Jutila, S. A.] US Army Corps Engineers, St Paul, MN 55101 USA. [Stefanski, M.] US Fish & Wildlife Serv, Upper Mississippi River Natl Wildlife & Fish Refu, Winona, MN 55987 USA. [Wege, G. J.] US Fish & Wildlife Serv, Ecol Serv Field Off, Bloomington, MN 55437 USA. [Benjamin, G. L.] Wisconsin Dept Nat Resources, La Crosse, WI 54601 USA. [Schlagenhaft, T. W.] Audubon, Red Wing, MN 55066 USA. RP Kenow, KP (reprint author), USGS, Upper Midwest Environm Sci Ctr, 2630 Fanta Reed Rd, La Crosse, WI 54603 USA. EM kkenow@usgs.gov OI Kenow, Kevin/0000-0002-3062-5197; Newton, Teresa/0000-0001-9351-5852 NR 31 TC 3 Z9 3 U1 5 U2 11 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1535-1459 EI 1535-1467 J9 RIVER RES APPL JI River Res. Appl. PD MAR PY 2016 VL 32 IS 3 BP 295 EP 308 DI 10.1002/rra.2857 PG 14 WC Environmental Sciences; Water Resources SC Environmental Sciences & Ecology; Water Resources GA DG8SU UT WOS:000372354700007 ER PT J AU Brusnahan, JS Poret, JC Moretti, JD Shaw, AP Sadangi, RK AF Brusnahan, Jason S. Poret, Jay C. Moretti, Jared D. Shaw, Anthony P. Sadangi, Rajendra K. TI Use of Magnesium Diboride as a "Green" Fuel for Green Illuminants SO ACS SUSTAINABLE CHEMISTRY & ENGINEERING LA English DT Article DE Sustainable pyrotechnics; Illuminants; Fireworks; Magnesium diboride; Barium-free ID BORON-CARBIDE; PYROTECHNIC FORMULATIONS; LIGHT ILLUMINANTS; BARIUM; MGB2 AB We report here on the use of magnesium diboride (MgB2) as a barium-free alternative for the pyrotechnic generation of green light. Formulations employing KNO3 as the oxidizer, MgB2 as the fuel, and various binders and additives were investigated. Upon combustion, the compositions were found to generate the photochemically active BO2 radical, which emits green light. Fixing the MgB2 content at 21 wt % gave the closest dominant wavelength (561.4 nm) to that desired for green illuminants and a spectral purity of 33%. The addition of burning rate modifiers to this system was found to inhibit the formation of the BO2 radical. Exchanging the KNO3 oxidizer for NH4ClO4 increased the spectral purity to 45%. Correlations between the results of thermodynamic modeling and the experimental data are also reported. C1 [Brusnahan, Jason S.] Def Sci & Technol Grp, Edinburgh, SA 5111, Australia. [Poret, Jay C.; Moretti, Jared D.; Shaw, Anthony P.; Sadangi, Rajendra K.] US Army RDECOM ARDEC, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07806 USA. RP Brusnahan, JS (reprint author), Def Sci & Technol Grp, Edinburgh, SA 5111, Australia.; Moretti, JD (reprint author), US Army RDECOM ARDEC, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07806 USA. EM jason.brusnahan@defence.gov.au; jared.d.moretti.civ@mail.mil FU U.S. Army, RDECOM, ARDEC; Defence Science and Technology Group FX Eric Latalladi and Fred Moser are thanked for weighing starting materials and mixing and preparation of the pellets. The U.S. Army, RDECOM, ARDEC is thanked for funding this work. Jason Brusnahan thanks the Defence Science and Technology Group for funding his International Fellowship at Picatinny Arsenal, NJ, U.S.A. NR 35 TC 0 Z9 0 U1 6 U2 7 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 2168-0485 J9 ACS SUSTAIN CHEM ENG JI ACS Sustain. Chem. Eng. PD MAR PY 2016 VL 4 IS 3 BP 1827 EP 1833 DI 10.1021/acssuschemeng.6b00041 PG 7 WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Chemical SC Chemistry; Science & Technology - Other Topics; Engineering GA DG0LD UT WOS:000371755400141 ER PT J AU Rose, LF Chan, RK AF Rose, Lloyd F. Chan, Rodney K. TI The Burn Wound Microenvironment SO ADVANCES IN WOUND CARE LA English DT Review ID GROWTH-FACTOR-BETA; ORGAN DYSFUNCTION SYNDROME; SOLID LIPID NANOPARTICLES; THERMAL-INJURY; STEM-CELLS; INFLAMMATORY RESPONSES; POSTBURN PATIENTS; SKIN SUBSTITUTES; CUTANEOUS WOUNDS; CRITICAL ILLNESS AB Significance: While the survival rate of the severely burned patient has improved significantly, relatively little progress has been made in treatment or prevention of burn-induced long-term sequelae, such as contraction and fibrosis. Recent Advances: Our knowledge of the molecular pathways involved in burn wounds has increased dramatically, and technological advances now allow large-scale genomic studies, providing a global view of wound healing processes. Critical Issues: Translating findings from a large number of in vitro and preclinical animal studies into clinical practice represents a gap in our understanding, and the failures of a number of clinical trials suggest that targeting single pathways or cytokines may not be the best approach. Significant opportunities for improvement exist. Future Directions: Study of the underlying molecular influences of burn wound healing progression will undoubtedly continue as an active research focus. Increasing our knowledge of these processes will identify additional therapeutic targets, supporting informed clinical studies that translate into clinical relevance and practice. C1 [Rose, Lloyd F.; Chan, Rodney K.] US Army, Inst Surg Res, Brook Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Chan, RK (reprint author), US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. EM rodney.k.chan.ctr@mail.mil NR 123 TC 0 Z9 0 U1 5 U2 9 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 2162-1918 EI 2162-1934 J9 ADV WOUND CARE JI Adv. Wound Care PD MAR 1 PY 2016 VL 5 IS 3 BP 106 EP 118 DI 10.1089/wound.2014.0536 PG 13 WC Dermatology SC Dermatology GA DF4QK UT WOS:000371334400003 PM 26989577 ER PT J AU Heavens, KR Charkoudian, N O'Brien, C Kenefick, RW Cheuvront, SN AF Heavens, Kristen R. Charkoudian, Nisha O'Brien, Catherine Kenefick, Robert W. Cheuvront, Samuel N. TI Noninvasive assessment of extracellular and intracellular dehydration in healthy humans using the resistance-reactance-score graph method SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Article DE volume depletion; hydration assessment; BIVA; hypohydration; hypovolemia ID BODY-WATER COMPARTMENTS; BIOELECTRICAL-IMPEDANCE; BIOIMPEDANCE SPECTROSCOPY; DIAGNOSTIC-ACCURACY; MARKERS; STRESS; PLASMA; VOLUME; BLOOD; MEN AB Background: Few dehydration assessment measures provide accurate information; most are based on reference change values and very few are diagnostically accurate from a single observation or measure. Bioelectrical impedance may lack the precision to detect common forms of dehydration in healthy individuals. Limitations in bioimpedance may be addressed by a unique resistance reactance (RXc)-score graph method, which transforms vector components into z scores for use with any impedance analyzer in any population. Objective: We tested whether the RXc-score graph method provides accurate single or serial assessments of dehydration when compared with gold-standard measures of total body water by using stable isotope dilution (deuterium oxide) combined with body weight changes. Design: We retrospectively analyzed data from a previous study in which 9 healthy young men participated in 3 trials: euhydration (EUH), extracellular dehydration (ED; via a diuretic), and intracellular dehydration (ID; via exercise in the heat). Results: Participants lost 4-5% of their body weight during the dehydration trials; volume loss was similar between trials (ID compared with ED group: 3.5 +/- 0.8 compared with 3.0 +/- 0.6 L; P > 0.05). Despite significant losses of body water, most RXc vector scores for ED and ID groups were classified as "normal" (within the 75% population tolerance ellipse). However, directional displacement of vectors was consistent with loss of volume in both ED and ID conditions compared with the EUH condition and tended to be longer in ED than in ID conditions (P = 0.054). Conclusions: We conclude that, whereas individual RXc-score graph values do not provide accurate detection of dehydration from single measurements, directional changes in vector values from serial measurements are consistent with fluid loss for both ED and ID conditions. The RXc-score graph method may therefore alert clinicians to changes in hydration state, which may bolster the interpretation of other recognized change measures of hydration. C1 [Heavens, Kristen R.; Charkoudian, Nisha; O'Brien, Catherine; Kenefick, Robert W.; Cheuvront, Samuel N.] US Army, Environm Med Res Inst, Natick, MA 01760 USA. RP Cheuvront, SN (reprint author), US Army, Environm Med Res Inst, Natick, MA 01760 USA. EM samuel.n.cheuvront.civ@mail.mil FU US Army Medical Research and Materiel Command FX Supported by the US Army Medical Research and Materiel Command. NR 28 TC 0 Z9 0 U1 2 U2 2 PU AMER SOC NUTRITION-ASN PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0002-9165 EI 1938-3207 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD MAR PY 2016 VL 103 IS 3 BP 724 EP 729 DI 10.3945/ajcn.115.115352 PG 6 WC Nutrition & Dietetics SC Nutrition & Dietetics GA DF8ZO UT WOS:000371650200008 PM 26843158 ER PT J AU DiStefano, LJ Marshall, SW Padua, DA Peck, KY Beutler, AI de la Motte, SJ Frank, BS Martinez, JC Cameron, KL AF DiStefano, Lindsay J. Marshall, Stephen W. Padua, Darin A. Peck, Karen Y. Beutler, Anthony I. de la Motte, Sarah J. Frank, Barnett S. Martinez, Jessica C. Cameron, Kenneth L. TI The Effects of an Injury Prevention Program on Landing Biomechanics Over Time SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article DE biomechanics; neuromuscular training; military ID RANDOMIZED-CONTROLLED-TRIAL; CRUCIATE LIGAMENT INJURY; LOWER-EXTREMITY INJURY; ERROR SCORING SYSTEM; JUMP-ACL; SOCCER PLAYERS; FEMALE SOCCER; BALANCE; DESIGN; TOOL AB Background: Knowledge is limited regarding how long improvements in biomechanics remain after completion of a lower extremity injury prevention program. Purpose: To evaluate the effects of an injury prevention program on movement technique and peak vertical ground-reaction forces (VGRF) over time compared with a standard warm-up (SWU) program. Study Design: Controlled laboratory study. Methods: A total of 1104 incoming freshmen (age range, 17-22 years) at a military academy in the United States volunteered to participate. Participants were cluster-randomized by military company to either the Dynamic Integrated Movement Enhancement (DIME) injury prevention program or SWU. A random subsample of participants completed a standardized jump-landing task at each time point: immediately before the intervention (PRE), immediately after (POST), and 2 (POST2M), 4 (POST4M), 6 (POST6M), and 8 months (POST8M) after the intervention. VGRF data collected during the jump-landing task were normalized to body weight (%BW). The Landing Error Scoring System (LESS) was used to evaluate movement technique during the jump landing. The change scores () for each variable (LESS, VGRF) between the group's average value at PRE and each time point were calculated. Separate univariate analyses of variance were performed to evaluate group differences. Results: The results showed a greater decrease in mean (SD) VGRF in the DIME group compared with the SWU group at all retention time points: POST2M (SWU [(%BW)], -0.13 0.82; DIME, -0.62 +/- 0.91; P = .001), POST4M (SWU, -0.15 +/- 0.98; DIME,-0.46 +/- 0.64; P = .04), POST6M (SWU, -0.04 +/- 0.96; DIME, -0.53 +/- 0.83; P = .004), and POST8M (SWU, 0.38 +/- 0.95; DIME, -0.11 +/- 0.98; P = .003), but there was not a significant improvement in the DIME group between PRE and POST8M ((%BW), -0.11 +/- 0.98). No group differences in LESS were observed. Conclusion: The study findings demonstrated that an injury prevention program performed as a warm-up can reduce vertical ground-reaction forces compared with a standard warm-up but a maintenance program is likely necessary in order for continued benefit. Clinical Relevance: Injury prevention programs may need to be performed constantly, or at least every sport season, in order for participants to maintain the protective effects against injury. C1 [DiStefano, Lindsay J.; Marshall, Stephen W.; Padua, Darin A.; Peck, Karen Y.; Beutler, Anthony I.; de la Motte, Sarah J.; Frank, Barnett S.; Martinez, Jessica C.; Cameron, Kenneth L.] US Mil Acad, West Point, NY 10996 USA. [DiStefano, Lindsay J.; Martinez, Jessica C.] Univ Connecticut, Dept Kinesiol, Storrs, CT USA. [Marshall, Stephen W.] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA. [Padua, Darin A.; Frank, Barnett S.] Univ N Carolina, Dept Exercise & Sport Sci, Chapel Hill, NC USA. [Peck, Karen Y.; Cameron, Kenneth L.] Keller Army Community Hosp, John Feagin Sports Med Fellowship, West Point, NY USA. [Beutler, Anthony I.; de la Motte, Sarah J.] Uniformed Serv Univ Hlth Sci, Dept Family Med, Bethesda, MD 20814 USA. RP DiStefano, LJ (reprint author), Univ Connecticut, Dept Kinesiol, Storrs, CT USA. EM lindsay.distefano@uconn.edu OI Cameron, Kenneth/0000-0002-6276-4482 FU United States Military Academy Department of Physical Education FX The authors acknowledge the United States Military Academy Department of Physical Education for supporting this project. They also acknowledge COL Greg Daniels, Dr Jeffrey Coelho, Kristen Koltun, Stephanie DeNicolo, Hayley Root, Timothy Mauntel, and Molly Grasso, and all the other invaluable research assistants for their help on this project. NR 28 TC 0 Z9 0 U1 2 U2 13 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0363-5465 EI 1552-3365 J9 AM J SPORT MED JI Am. J. Sports Med. PD MAR PY 2016 VL 44 IS 3 BP 767 EP 776 DI 10.1177/0363546515621270 PG 10 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA DF9CQ UT WOS:000371658300033 PM 26792707 ER PT J AU Joyner, MJ Wallin, BG Charkoudian, N AF Joyner, Michael J. Wallin, B. Gunnar Charkoudian, Nisha TI Sex differences and blood pressure regulation in humans SO EXPERIMENTAL PHYSIOLOGY LA English DT Article; Proceedings Paper CT Experimental Biology Meeting 2015 CY MAR 28-APR 01, 2015 CL Boston, MA SP Amer Assoc Anatomists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Investigat Pathol, Amer Soc Nutr, Amer Soc Pharmacol & Expt Therapeut ID SYMPATHETIC-NERVE ACTIVITY; YOUNG-WOMEN; ORAL-CONTRACEPTIVES; BAROREFLEX SENSITIVITY; HEMODYNAMIC BALANCE; AUTONOMIC SUPPORT; NEURAL-CONTROL; OVARIAN CYCLE; HEALTHY WOMEN; MEN AB New Findings What is the topic of this review? Over the past decade, our team has investigated interindividual variability in human blood pressure regulation. What advances does it highlight? In men, we have found a tight relationship between indices of sympathetic activity and vascular resistance across the age span. This relationship is absent in young women but seen in postmenopausal women. These sex and age differences in vascular resistance are largely a result of changes in the balance of vasodilating and vasoconstricting adrenergic receptor tone. When these changes are considered along with cardiac output, a coherent picture is beginning to emerge of why blood pressure rises more with age in women than men. Arterial pressure is a key regulated variable in the cardiovascular system with important health implications. Over the last 12years, we have used physiological measurements, including muscle sympathetic nerve activity (MSNA), to explore the balance among mean arterial blood pressure, cardiac output and total peripheral resistance (TPR) in normotensive humans. We have shown that these determinants of blood pressure can vary widely in different subjects and how they vary depends on sex and age. In young men, there is a direct relationship between MSNA and TPR but no relationship with blood pressure. This is because cardiac output is proportionally lower in those with high MSNA and TPR. In contrast, in young women there is no relationship between MSNA and TPR (or cardiac output); this is because -adrenergic vasodilator mechanisms offset -adrenergic vasoconstriction. Thus, blood pressure is unrelated to MSNA in young women. In older women, -adrenergic vasodilator mechanisms are diminished, and a direct relationship between MSNA and TPR is seen. In older men, the relationships among these variables are less clear cut, perhaps owing to age-related alterations in endothelial function. With ageing, the relationship between MSNA and blood pressure becomes positive, more so in women than in men. The finding that the physiological control of blood pressure is so different in men and women and that it varies with age suggests that future studies of mechanisms of hypertension will reveal corresponding differences among groups. C1 [Joyner, Michael J.] Mayo Clin, Dept Anesthesiol, 200 First St SW, Rochester, MN 55905 USA. [Wallin, B. Gunnar] Gothenburg Univ, Sahlgren Acad Gothenburg, Inst Neurosci & Physiol, Gothenburg, Sweden. [Charkoudian, Nisha] US Army, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. RP Joyner, MJ (reprint author), Mayo Clin, Dept Anesthesiol, 200 First St SW, Rochester, MN 55905 USA. EM joyner.michael@mayo.edu FU NIH [HL83947, UL1RR024150]; Caywood professorship FX The collaborative studies of the authors on these topics were supported by NIH HL83947, NIH UL1RR024150 and the Caywood professorship. NR 30 TC 11 Z9 11 U1 4 U2 15 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0958-0670 EI 1469-445X J9 EXP PHYSIOL JI Exp. Physiol. PD MAR 1 PY 2016 VL 101 IS 3 BP 349 EP 355 DI 10.1113/EP085146 PG 7 WC Physiology SC Physiology GA DF7IL UT WOS:000371531200003 PM 26152788 ER PT J AU Jarrett, JB Lounsbery, JL D'Amico, F Dickerson, LM Franko, J Nagle, J Seehusen, DA Wilson, SA AF Jarrett, Jennie B. Lounsbery, Jody L. D'Amico, Frank Dickerson, Lori M. Franko, John Nagle, John Seehusen, Dean A. Wilson, Stephen A. TI Clinical Pharmacists as Educators in Family Medicine Residency Programs: A CERA Study of Program Directors SO FAMILY MEDICINE LA English DT Article ID BOARD CERTIFICATION; ECONOMIC OUTCOMES; TRAINING-PROGRAM; SERVICES; MANAGEMENT; CARE; RECOMMENDATIONS; PRACTITIONERS; SPECIALISTS; EXPERIENCE AB BACKGROUND AND OBJECTIVES: The clinical pharmacist's role within family medicine residency programs (FMRPs) is well established. However, there is limited information regarding perceptions of program directors (PDs) about clinical pharmacy educators. The study objectives were (1) to estimate the prevalence of clinical pharmacists within FMRPs and (2) to determine barriers and motivations for incorporation of clinical pharmacists as educators. METHODS: The Council of Academic Family Medicine Educational Research Alliance (CERA) distributed an electronic survey to PDs. Questions addressed formalized pharmacotherapy education, clinical pharmacists in educator roles, and barriers and benefits of clinical pharmacists in FMRPs. RESULTS: The overall response rate was 50% (224/451). Seventy-six percent (170/224) of the responding PDs reported that clinical pharmacists provide pharmacotherapy education in their FMRPs, and 57% (97/170) consider clinical pharmacists as faculty members. In programs with clinical pharmacists, 72% (83/116) of PDs reported having a systematic approach for teaching pharmacotherapy versus 22% (21/95) in programs without. In programs without clinical pharmacists, the top barrier to incorporation was limited ability to bill for clinical services 48% (43/89) versus 29% (32/112) in programs with clinical pharmacists. In both programs with and without clinical pharmacists, the top benefit of having clinical pharmacists was providing a collaborative approach to pharmacotherapy education for residents (35% and 36%, respectively). CONCLUSIONS: Less than half of FMRPs incorporate clinical pharmacists as faculty members. Despite providing collaborative approaches to pharmacotherapy education, their limited ability to bill for services is a major barrier. C1 [Jarrett, Jennie B.; D'Amico, Frank; Wilson, Stephen A.] Univ Pittsburgh, Med Ctr, St Margaret Family Med Residency Program, Pittsburgh, PA 15260 USA. [Lounsbery, Jody L.] Univ Minnesota, Coll Pharm, Dept Pharmaceut Care & Hlth Syst, Minneapolis, MN 55455 USA. [Lounsbery, Jody L.] Univ Minnesota, Sch Med, Dept Family Med & Community Hlth, Minneapolis, MN 55455 USA. [Wilson, Stephen A.] Univ Pittsburgh, Dept Family Med, Pittsburgh, PA 15260 USA. [Dickerson, Lori M.] Med Univ S Carolina, Dept Family Med, Charleston, SC USA. [Franko, John] E Tennessee State Univ, Dept Family Med, Johnson City, TN 37614 USA. [Nagle, John] Univ Colorado Family Med Residency, Denver, CO USA. [Seehusen, Dean A.] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA USA. RP Lounsbery, JL (reprint author), Univ Minnesota, Coll Pharm, 308 Harvard St SE,Room 5-110 WDH, Minneapolis, MN 55455 USA. EM loun0015@umn.edu NR 28 TC 3 Z9 3 U1 3 U2 6 PU SOC TEACHERS FAMILY MEDICINE PI LEAWOOD PA 11400 TOMAHAWK CREEK PARKWAY, STE 540, LEAWOOD, KS 66207 USA SN 0742-3225 EI 1938-3800 J9 FAM MED JI Fam. Med. PD MAR PY 2016 VL 48 IS 3 BP 180 EP 186 PG 7 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA DG2QY UT WOS:000371913900003 PM 26950906 ER PT J AU Lee, AG Tarver, WJ Mader, TH Gibson, CR Hart, SF Otto, CA AF Lee, Andrew G. Tarver, William J. Mader, Thomas H. Gibson, Charles Robert Hart, Stephen F. Otto, Christian A. TI Neuro-Ophthalmology of Space Flight SO JOURNAL OF NEURO-OPHTHALMOLOGY LA English DT Review ID HEAD-DOWN TILT; IDIOPATHIC INTRACRANIAL HYPERTENSION; CEREBROSPINAL-FLUID OUTFLOW; COTTON-WOOL SPOTS; OPTIC DISC EDEMA; CHOROIDAL FOLDS; ACQUIRED HYPEROPIA; INTRAOCULAR-PRESSURE; REFRACTIVE CHANGES; RADIAL KERATOTOMY AB Background:To describe the history, clinical findings, and possible pathogenic etiologies of the constellation of neuro-ophthalmic findings discovered in astronauts after long-duration space flight and to discuss the terrestrial implications of such findings.Evidence Acquisition:Retrospective review of published observational, longitudinal examination of neuro-ophthalmic findings in astronauts after long-duration space flight; analysis of postflight questionnaires regarding in-flight vision changes in approximately 300 additional astronauts; and hypothesis generating for developing possible future countermeasures and potential implications for neuro-ophthalmic disorders on Earth. Astronauts with neuro-ophthalmic findings, which were not present at the start of a space flight mission and only seen on return from long-duration space missions to the International Space Station, will be discussed.Results:After 6 months of space flight, 7 astronauts had ophthalmic findings consisting of optic disc edema in 5, globe flattening in 5, choroidal folds in 5, cotton-wool spots in 3, nerve fiber layer thickening detected by optical coherence tomography in 6, and decreased near vision in 6. Five of 7 astronauts with near vision complaints had a hyperopic shift +0.50 diopters (D) between pre-/post-mission spherical equivalent refraction in 1 or both eyes (range, +0.50 to +1.75 D). These 5 astronauts showed globe flattening on magnetic resonance imaging. A total of 6 lumbar punctures have been performed to date (4 in the originally described cohort) and documented opening pressures of 18, 22, 21, 21.5, 28, and 28.5 cm H2O. These were performed at 8, 66, 19, 7, 12, and 57 days after mission, respectively. The 300 postflight questionnaires documented that approximately 29% and 60% of astronauts on short-duration and long-duration missions, respectively, experienced a degradation in distant and near visual acuity. Some of these vision changes remain unresolved for years after flight. Several possible pathogenic mechanisms, as well as potential countermeasures and discussion of possible terrestrial implications, are described.Conclusions:We previously hypothesized that the optic nerve and ocular changes that we described in astronauts may be the result of orbital and cranial cephalad fluid shifts brought about by prolonged microgravity exposure. The findings we reported previously and continue to see in astronauts may represent parts of a spectrum of ocular and cerebral responses to extended microgravity exposure. Future investigations hopefully will lead to countermeasures that can be used to eliminate or lessen the magnitude of these potentially harmful findings before long-duration space flight including the possibility of a manned mission to Mars. C1 [Lee, Andrew G.; Gibson, Charles Robert] Houston Methodist Hosp, Dept Ophthalmol, Houston, TX 77030 USA. [Lee, Andrew G.] Baylor Coll Med, Dept Ophthalmol, Houston, TX 77030 USA. [Lee, Andrew G.] Weill Cornell Med Coll, Dept Ophthalmol, New York, NY USA. [Lee, Andrew G.] Weill Cornell Med Coll, Dept Neurol, New York, NY USA. [Lee, Andrew G.] Weill Cornell Med Coll, Dept Neurosurg, New York, NY USA. [Lee, Andrew G.] Univ Texas Med Branch, Dept Ophthalmol, Galveston, TX 77555 USA. [Lee, Andrew G.] Univ Iowa Hosp & Clin, Dept Ophthalmol, Iowa City, IA 52242 USA. [Lee, Andrew G.] Univ Texas MD Anderson Canc Ctr, Sect Ophthalmol, Houston, TX 77030 USA. [Tarver, William J.; Hart, Stephen F.] NASA, Space Med Div, Washington, DC 20546 USA. [Mader, Thomas H.] US Army, Cooper Landing, AK USA. [Gibson, Charles Robert] Coastal Eye Associates, Webster, TX USA. [Otto, Christian A.] Univ Space Res Assoc, NASA, Washington, DC USA. RP Lee, AG (reprint author), Houston Methodist Hosp, Blanton Eye Inst, Dept Ophthalmol, 6560 Fannin St,Scurlock 450, Houston, TX 77030 USA. EM aglee@houstonmethodist.org NR 60 TC 2 Z9 2 U1 2 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1070-8022 EI 1536-5166 J9 J NEURO-OPHTHALMOL JI J. Neuro-Ophthal. PD MAR PY 2016 VL 36 IS 1 BP 85 EP 91 DI 10.1097/WNO.0000000000000334 PG 7 WC Clinical Neurology; Ophthalmology SC Neurosciences & Neurology; Ophthalmology GA DF7JM UT WOS:000371534000020 PM 26828842 ER PT J AU Mader, TH Gibson, CR Hart, SF Lee, AG AF Mader, Thomas H. Gibson, C. Robert Hart, Stephen F. Lee, Andrew G. TI Asymmetric Papilledema in Idiopathic Intracranial Hypertension: Comment SO JOURNAL OF NEURO-OPHTHALMOLOGY LA English DT Letter ID DURATION SPACE-FLIGHT; OPTIC DISC EDEMA; ASTRONAUT C1 [Mader, Thomas H.] US Army, Moab, UT USA. [Gibson, C. Robert] Coastal Eye Associates, Webster, TX USA. [Hart, Stephen F.] NASA, Div Life Sci, Houston, TX USA. [Lee, Andrew G.] Methodist Hosp, Dept Ophthalmol, 6535 Fannin, Houston, TX 77030 USA. RP Mader, TH (reprint author), US Army, Moab, UT USA. NR 5 TC 0 Z9 0 U1 2 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1070-8022 EI 1536-5166 J9 J NEURO-OPHTHALMOL JI J. Neuro-Ophthal. PD MAR PY 2016 VL 36 IS 1 BP 111 EP 112 PG 2 WC Clinical Neurology; Ophthalmology SC Neurosciences & Neurology; Ophthalmology GA DF7JM UT WOS:000371534000024 PM 26885711 ER PT J AU Horsmon, MS Vincelli, NM Taylor, JT Kristovich, RL AF Horsmon, Michael S. Vincelli, Nicole M. Taylor, James T. Kristovich, Robert L. TI An Impedance-Based Model for the Assessment of Cardiopulmonary Function in Rabbits SO JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE LA English DT Article ID PNEUMOGRAPH AB Improving the quality of physiologic data collected from research animals is most easily accomplished by collecting as much information as possible from a single subject, thereby reducing animal use and error associated with satellite groups. We investigated the feasibility of using a large-animal implantable telemetry device in New Zealand white rabbits (n = 6). The first task was to develop an implantation technique that yielded calibrated tidal volume (Vt) measurements that were within 10% of those obtained simultaneously from a pneumotachograph, a low-noise electrocardiogram, and stable blood pressure. The second task was to challenge implanted rabbits with the respiratory stimulant doxapram to assess linearity of the calibration across a range of Vt. Of the 3 electrode placements attempted, only one resulted in calibrations consistently below 10% error. Optimal electrode placement resulted in calibrated Vt measurements within 1.7% +/- 0.3% of those obtained from a pneumotachograph during normal tidal breathing, 7.3% +/- 0.7% of those after saline injection, and 6.0% +/- 0.5% of those after doxapram injection. The Vt range was 9 to 15 mL for normal tidal breathing and saline injection and 25 to 30 mL after doxapram injection. Increases in mean arterial pressure of 25.0 +/- 6.82 mm Hg and decreases in heart rate of 56.3 +/- 6.82 bpm were associated with doxapram injection only. Our findings represent the first time that multiple cardiopulmonary endpoints have been assessed by telemetry in conscious, restrained rabbits. Whether animal position affects calibration accuracy warrants investigation. C1 [Horsmon, Michael S.; Kristovich, Robert L.] US Army, Edgewood Chem Biol Ctr, Gunpowder, MD USA. [Vincelli, Nicole M.; Taylor, James T.] Leidos, Gunpowder, MD USA. RP Horsmon, MS (reprint author), US Army, Edgewood Chem Biol Ctr, Gunpowder, MD USA. EM michael.s.horsmon.civ@mail.mil FU Defense Threat Reduction Agency FX This study was funded by the Defense Threat Reduction Agency; the agency did not play any role in the study design, collection, analysis, and interpretation of the data, or writing of this report. The decision to publish this report is authorized by the agency. NR 13 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI MEMPHIS PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA SN 1559-6109 J9 J AM ASSOC LAB ANIM JI J. Amer. Assoc. Lab. Anim. Sci. PD MAR PY 2016 VL 55 IS 2 BP 213 EP 220 PG 8 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA DG1SR UT WOS:000371848300013 PM 27025814 ER PT J AU Yuffa, AJ Gutierrez, Y Sanz, JM de la Osa, RA Saiz, JM Gonzalez, F Moreno, F Videen, G AF Yuffa, Alex J. Gutierrez, Yael Sanz, Juan M. Alcaraz de la Osa, Rodrigo Saiz, Jose M. Gonzalez, Francisco Moreno, Fernando Videen, Gorden TI Near- and far-field scattering resonance frequency shift in dielectric and perfect electric conducting cylinders SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION LA English DT Article ID SURFACE; PARTICLES AB The ability to infer near-field scattering properties from far-field measurements is of paramount importance in nano-optics. Recently we derived an approximate formula for predicting the frequency shift between near-and far-field intensity peaks in the case of a dielectric sphere. In this work we demonstrate that almost an identical formula can be used to predict the resonance shift of a dielectric cylinder and a perfectly conducting cylinder. We find the redshift of the resonance peak of the perfect electric conducting cylinder to be approximately 2 orders of magnitude greater than for the dielectric cylinder. The errors in our approximate analytic formula for predicting the redshift are approximately only twice as great. Furthermore, we apply the redshift formula to a silicon cylinder and discuss its magneto-dielectric properties, which may be of interest in design of metamaterials. (C) 2016 Optical Society of America C1 [Yuffa, Alex J.; Videen, Gorden] Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Gutierrez, Yael; Sanz, Juan M.; Alcaraz de la Osa, Rodrigo; Saiz, Jose M.; Gonzalez, Francisco; Moreno, Fernando; Videen, Gorden] Univ Cantabria, Dept Fis Aplicada, Fac Ciencias, Grp Opt, Avda Los Castros S-N, E-39005 Santander, Spain. RP Yuffa, AJ (reprint author), Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM ayuffa@gmail.com RI Yuffa, Alex/B-5498-2014 OI Yuffa, Alex/0000-0002-3600-1131 NR 20 TC 0 Z9 0 U1 0 U2 2 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1084-7529 EI 1520-8532 J9 J OPT SOC AM A JI J. Opt. Soc. Am. A-Opt. Image Sci. Vis. PD MAR 1 PY 2016 VL 33 IS 3 BP 391 EP 395 DI 10.1364/JOSAA.33.000391 PG 5 WC Optics SC Optics GA DG0UR UT WOS:000371781700050 PM 26974908 ER PT J AU McAnally, WH Kirby, R Hodge, SH Welp, TL Greiser, N Shrestha, P McGowan, D Turnipseed, P AF McAnally, W. H. Kirby, R. Hodge, S. H. Welp, T. L. Greiser, N. Shrestha, P. McGowan, D. Turnipseed, P. TI Nautical Depth for US Navigable Waterways: A Review SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING LA English DT Review DE Dredging; Fluid mud; Channels; Ports; Harbors; Nautical depth; Bathymetric survey; Echo sounder ID FLUID MUD; NAVIGATION; AREAS; MANAGEMENT; ESTUARIES; LAKES; BAYS AB The present state of navigation engineering knowledge concerning nautical depth in ports and waterways with fluid mud is summarized to examine the potential for successful application of the nautical depth concept in U.S. navigable waterways. Nautical depth defines a safe and effective channel bottom criterion in areas where fluid mud confounds conventional acoustic (echo sounder) surveying methods. Fluid mud is a high-concentration suspension that typically behaves as a non-Newtonian fluid. It occurs in ports and channels on all U.S. coastlines and accounts for a significant portion of the United States' $1 billion dredging expense. Nautical depth has been adopted in multiple ports on three continents. Where nautical depth application is appropriate, it often reduces dredging frequency and dredged material volume and can provide water quality benefits. Multiple experiments and field experience have shown that vessels can safely transit areas with fluid mud below the keel. The United States' adoption of the nautical depth concept for select ports and waterways can be expected to reduce dredging frequency and volumes. It offers potential economic and environmental benefits but will require a consensus among federal, state, and local organizations with responsibilities for constructing, operating, maintaining, marking, and using navigable waterways. C1 [McAnally, W. H.] Mississippi State Univ, 2 Res Blvd, Starkville, MS 39762 USA. [Kirby, R.] Ravensrodd Consultants, 6 Queens Dr, Taunton TA1 4XW, Somerset, England. [Hodge, S. H.] Attorney Law, 4107 Franklin Ave, Gulfport, MS 39507 USA. [Welp, T. L.] US Army, COE Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. [Greiser, N.] Emder Grunder Innenzentrum GmbH EGZ, Consultants Sell Greiser GmbH & Co KG, Zum Nordkai 16, D-26725 Emden, Germany. [Shrestha, P.] Exponent, 320 Goddard 200, Irvine, CA 92618 USA. [McGowan, D.] Insight, POB 4200, Jackson, MS 39296 USA. [Turnipseed, P.] US Geol Survey Southeast Reg, 3535 S Sherwood Forest Blvd,Suite 120, Baton Rouge, LA 70816 USA. RP McAnally, WH (reprint author), Mississippi State Univ, 2 Res Blvd, Starkville, MS 39762 USA. EM whmcanally@gmail.com NR 66 TC 1 Z9 1 U1 6 U2 10 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-950X EI 1943-5460 J9 J WATERW PORT COAST JI J. Waterw. Port Coast. Ocean Eng. PD MAR PY 2016 VL 142 IS 2 AR 04015014 DI 10.1061/(ASCE)WW.1943-5460.0000301 PG 13 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA DF9NF UT WOS:000371687300001 ER PT J AU George, AA Hargrove, VM Molina, DK AF George, Alan A. Hargrove, Veronica M. Molina, D. Kimberley TI Postmortem Propofol Levels A Case of Residual Detection Long After Administration SO AMERICAN JOURNAL OF FORENSIC MEDICINE AND PATHOLOGY LA English DT Article DE propofol; residual; Diprivan; forensic pathology; postmortem; detection ID PHARMACOKINETICS; LETHAL; ABUSE; DEATH; PHARMACODYNAMICS; INTOXICATION; SEDATION AB Propofol has gained notoriety in recent years because of its involvement in high-profile deaths and has increasingly become a drug of misuse and abuse particularly by health care personnel with easy access to it. In addition, propofol has also been used for more nefarious purposes such as murder and suicide. These, coupled with the drug's routine use for both major and minor medical procedures, provide ample opportunities for it to be implicated as a cause of death or contributing factor. In such instances, forensic investigators may be faced with the task of not only detecting the presence of propofol on postmortem toxicology screening, but also determining if it was indeed responsible for the decedent's demise. While propofol has a high volume of distribution, it is thought to equilibrate and be eliminated rapidly and not show significant tissue accumulation. However, this article presents a case illustrating that propofol can accumulate in the tissues and may be found up to a week after administration. This capacity to accumulate implies that postmortem detection does not necessarily confirm administration near the time of death, and further investigation needs to be undertaken to determine the timeline of events in order to rule out other factors, such as recent medical interventions, before attributing the cause of death to the presence of the drug. C1 [George, Alan A.] Brooke Army Med Ctr, Dept Pathol, Ft Sam Houston, TX 78234 USA. [Hargrove, Veronica M.; Molina, D. Kimberley] Bexar Cty Med Examiners Off, 7337 Louis Pasteur Dr, San Antonio, TX 78229 USA. RP Molina, DK (reprint author), Bexar Cty Med Examiners Off, 7337 Louis Pasteur Dr, San Antonio, TX 78229 USA. EM kmolina@bexar.org NR 20 TC 1 Z9 1 U1 3 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0195-7910 EI 1533-404X J9 AM J FOREN MED PATH JI Am. J. Forensic Med. Pathol. PD MAR PY 2016 VL 37 IS 1 BP 4 EP 6 DI 10.1097/PAF.0000000000000209 PG 3 WC Medicine, Legal; Pathology SC Legal Medicine; Pathology GA DE2WT UT WOS:000370488800002 PM 26513757 ER PT J AU Scaravilli, V Kreyer, S Belenkiy, S Linden, K Zanella, A Li, YS Dubick, MA Cancio, LC Pesenti, A Batchinsky, AI AF Scaravilli, Vittorio Kreyer, Stefan Belenkiy, Slava Linden, Katharina Zanella, Alberto Li, Yansong Dubick, Michael A. Cancio, Leopoldo C. Pesenti, Antonio Batchinsky, Andriy I. TI Extracorporeal Carbon Dioxide Removal Enhanced by Lactic Acid Infusion in Spontaneously Breathing Conscious Sheep SO ANESTHESIOLOGY LA English DT Article ID POSITIVE-PRESSURE VENTILATION; ACUTE RESPIRATORY-FAILURE; CO2 REMOVAL; MECHANICAL VENTILATION; GLUCOSE-METABOLISM; CARDIOGENIC-SHOCK; EXTRACELLULAR PH; LACTATE; INHALATION; MANAGEMENT AB Background: The authors studied the effects on membrane lung carbon dioxide extraction (VCO2ML), spontaneous ventilation, and energy expenditure (EE) of an innovative extracorporeal carbon dioxide removal (ECCO2R) technique enhanced by acidification (acid load carbon dioxide removal [ALCO(2)R]) via lactic acid. Methods: Six spontaneously breathing healthy ewes were connected to an extracorporeal circuit with blood flow 250 ml/min and gas flow 10 l/min. Sheep underwent two randomly ordered experimental sequences, each consisting of two 12-h alternating phases of ALCO(2)R and ECCO2R. During ALCO(2)R, lactic acid (1.5 mEq/min) was infused before the membrane lung. Caloric intake was not controlled, and animals were freely fed. VCO2ML, natural lung carbon dioxide extraction, total carbon dioxide production, and minute ventilation were recorded. Oxygen consumption and EE were calculated. Results: ALCO(2)R enhanced VCO2ML by 48% relative to ECCO2R (55.3 +/- 3.1 vs. 37.2 +/- 3.2 ml/min; P less than 0.001). During ALCO(2)R, minute ventilation and natural lung carbon dioxide extraction were not affected (7.88 +/- 2.00 vs. 7.51 +/- 1.89 l/min, P = 0.146; 167.9 +/- 41.6 vs. 159.6 +/- 51.8 ml/min, P = 0.063), whereas total carbon dioxide production, oxygen consumption, and EE rose by 12% each (223.53 +/- 42.68 vs. 196.64 +/- 50.92 ml/min, 215.3 +/- 96.9 vs. 189.1 +/- 89.0 ml/min, 67.5 +/- 24.0 vs. 60.3 +/- 20.1 kcal/h; P less than 0.001). Conclusions: ALCO(2)R was effective in enhancing VCO2ML. However, lactic acid caused a rise in EE that made ALCO(2)R no different from standard ECCO2R with respect to ventilation. The authors suggest coupling lactic acid-enhanced ALCO(2)R with active measures to control metabolism. C1 [Scaravilli, Vittorio; Zanella, Alberto] Univ Milano Bicocca, Dipartimento Sci Salute, Monza, MB, Italy. [Scaravilli, Vittorio; Kreyer, Stefan; Belenkiy, Slava; Linden, Katharina; Li, Yansong; Cancio, Leopoldo C.; Batchinsky, Andriy I.] US Army, Inst Surg Res, Comprehens Intens Care Res Task Area, Ft Sam Houston, TX 78234 USA. [Dubick, Michael A.] US Army, Inst Surg Res, Damage Control Resuscitat Task Area, Ft Sam Houston, TX 78234 USA. [Scaravilli, Vittorio; Kreyer, Stefan] Natl Acad, Natl Res Council, Washington, DC USA. [Kreyer, Stefan] Univ Hosp Bonn, Dept Anesthesiol & Intens Care Med, Bonn, Germany. [Linden, Katharina] Univ Hosp Bonn, Dept Pediat, Bonn, Germany. [Pesenti, Antonio] Univ Milan, Dipartimento Fisiopatol Med Chirurg & Trapianti, Milan, Italy. [Pesenti, Antonio] Osped Maggiore Policlin, Fdn IRCCS Ca Granda, Dipartimento Anestesia Rianimaz & Emergenza Urgen, Milan, Italy. RP Scaravilli, V (reprint author), Univ Milano Bicocca, Dipartimento Sci Salute, Monza, MB, Italy. EM vittorio.scaravilli@gmail.com FU U.S. Army through the In-House Laboratory Independent Research Program at the U.S. Army Institute of Surgical Research, San Antonio, Texas FX Funding for this study was provided by the U.S. Army through the In-House Laboratory Independent Research Program at the U.S. Army Institute of Surgical Research, San Antonio, Texas. NR 40 TC 1 Z9 1 U1 3 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0003-3022 EI 1528-1175 J9 ANESTHESIOLOGY JI Anesthesiology PD MAR PY 2016 VL 124 IS 3 BP 674 EP 682 DI 10.1097/ALN.0000000000000995 PG 9 WC Anesthesiology SC Anesthesiology GA DE5US UT WOS:000370698900021 PM 26756517 ER PT J AU Gazonas, GA Wildman, RA Hopkins, DA Scheidler, MJ AF Gazonas, George A. Wildman, Raymond A. Hopkins, David A. Scheidler, Michael J. TI Longitudinal impact of piezoelectric media SO ARCHIVE OF APPLIED MECHANICS LA English DT Article DE 1-D elastodynamics; Numerical inverse Laplace transform; Mathematica source code; d ' Alembert method; Dubner-Abate-Crump ID LAPLACE TRANSFORMS; NUMERICAL INVERSION; WAVES; IMPROVEMENT; TRANSDUCER; CONSTANTS; QUARTZ; STRAIN AB We consider the elastodynamic impact problem involving a one-dimensional finite-thickness piezoelectric flyer traveling at initial velocity V-0 that collides with (and adheres to) a stationary piezoelectric target of finite thickness backed by a semi-infinite non-piezoelectric elastic half-space. We derive expressions for the stress, velocity, and electric displacement in the target at all times after impact. A combined d'Alembert and Laplace transform method is used to derive new numerically based solutions for this class of transient wave propagation problems. A modified Dubner-Abate-Crump (DAC) algorithm is used to invert the analytical Laplace transform domain solutions to the time domain. Unlike many authors who neglect electromechanical coupling in the initially unstressed region ahead of the shock, we consider this effect, which gives rise to the development of a tensile stress wave within the piezoelectric target ahead of the shock. To solve the problem, we derive a new piezoelectric impact boundary condition and apply it to the problem of a finite quartz (Si) flyer impacting a lead zirconate titanate (PZT-4) target and find that the solutions obtained using the modified DAC algorithm compare well with those obtained using both a finite-difference time-domain method, and the commercial finite element code, COMSOL multiphysics. C1 [Gazonas, George A.; Wildman, Raymond A.; Hopkins, David A.; Scheidler, Michael J.] US Army Res Lab, ATTN RDRL WMM B, Aberdeen Proving Ground, MD 21005 USA. RP Gazonas, GA (reprint author), US Army Res Lab, ATTN RDRL WMM B, Aberdeen Proving Ground, MD 21005 USA. EM george.a.gazonas.civ@mail.mil; raymond.a.wildman.civ@mail.mil; david.a.hopkins.civ@mail.mil; michael.j.scheidler2.ctr@mail.mil OI Gazonas, George/0000-0002-2715-016X NR 31 TC 0 Z9 0 U1 0 U2 5 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0939-1533 EI 1432-0681 J9 ARCH APPL MECH JI Arch. Appl. Mech. PD MAR PY 2016 VL 86 IS 3 BP 497 EP 515 DI 10.1007/s00419-015-1042-3 PG 19 WC Mechanics SC Mechanics GA DF3JN UT WOS:000371240200007 ER PT J AU Marusich, LR Bakdash, JZ Onal, E Yu, MS Schaffer, J O'Donovan, J Hollerer, T Buchler, N Gonzalez, C AF Marusich, Laura R. Bakdash, Jonathan Z. Onal, Emrah Yu, Michael S. Schaffer, James O'Donovan, John Hoellerer, Tobias Buchler, Norbou Gonzalez, Cleotilde TI Effects of Information Availability on Command-and-Control Decision Making: Performance, Trust, and Situation Awareness SO HUMAN FACTORS LA English DT Article DE information; situation awareness; trust; decision making; command and control; network enabled operations ID COGNITIVE-ABILITIES; DYNAMIC-SYSTEMS; WORKING-MEMORY; TASK; ENVIRONMENTS; TIME AB Objective: We investigated how increases in task-relevant information affect human decision-making performance, situation awareness (SA), and trust in a simulated command-and-control (C2) environment. Background: Increased information is often associated with an improvement of SA and decision-making performance in networked organizations. However, previous research suggests that increasing information without considering the task relevance and the presentation can impair performance. Method: We used a simulated C2 task across two experiments. Experiment 1 varied the information volume provided to individual participants and measured the speed and accuracy of decision making for task performance. Experiment 2 varied information volume and information reliability provided to two participants acting in different roles and assessed decision-making performance, SA, and trust between the paired participants. Results: In both experiments, increased task-relevant information volume did not improve task performance. In Experiment 2, increased task-relevant information volume reduced self-reported SA and trust, and incorrect source reliability information led to poorer task performance and SA. Conclusion: These results indicate that increasing the volume of information, even when it is accurate and task relevant, is not necessarily beneficial to decision-making performance. Moreover, it may even be detrimental to SA and trust among team members. Application: Given the high volume of available and shared information and the safety-critical and time-sensitive nature of many decisions, these results have implications for training and system design in C2 domains. To avoid decrements to SA, interpersonal trust, and decision-making performance, information presentation within C2 systems must reflect human cognitive processing limits and capabilities. C1 [Marusich, Laura R.; Bakdash, Jonathan Z.; Buchler, Norbou] US Army Res Lab, Aberdeen Proving Ground, MD USA. [Onal, Emrah] SA Technol Inc, Marietta, GA USA. [Yu, Michael S.] Carnegie Mellon Univ, Pittsburgh, PA 15213 USA. [Schaffer, James] Univ Calif Santa Barbara, Four Eyes Lab, Santa Barbara, CA 93106 USA. [O'Donovan, John] Univ Calif Santa Barbara, Dept Comp Sci, Santa Barbara, CA 93106 USA. [Hoellerer, Tobias] Univ Calif Santa Barbara, Comp Sci, Santa Barbara, CA 93106 USA. [Gonzalez, Cleotilde] Carnegie Mellon Univ, Dynam Decis Making Lab, Pittsburgh, PA 15213 USA. RP Marusich, LR (reprint author), US Army Res Lab, Bldg 91012 Stn Ave, Ft Hood, TX 76544 USA. EM laura.r.marusich.ctr@mail.mil RI Yu, Michael/M-2041-2015 OI Yu, Michael/0000-0002-2445-4555 FU Network Science Collaborative Technology Alliance - U.S. Army Research Laboratory [W911NF-09-2-0053] FX This research was supported by the Network Science Collaborative Technology Alliance sponsored by the U.S. Army Research Laboratory under Cooperative Agreement No. W911NF-09-2-0053 and by an appointment to the U.S. Army Research Laboratory Postdoctoral Fellowship Program administered by the Oak Ridge Associated Universities. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the U.S. Army Research Laboratory or the U.S. government. NR 51 TC 3 Z9 3 U1 22 U2 35 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0018-7208 EI 1547-8181 J9 HUM FACTORS JI Hum. Factors PD MAR PY 2016 VL 58 IS 2 BP 301 EP 321 DI 10.1177/0018720815619515 PG 21 WC Behavioral Sciences; Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology SC Behavioral Sciences; Engineering; Psychology GA DF4PJ UT WOS:000371331400007 PM 26822796 ER PT J AU Gehrich, AP Lustik, MB Mehr, AA Patzwald, JR AF Gehrich, Alan P. Lustik, Michael B. Mehr, Allen A. Patzwald, Jason R. TI Risk of postoperative urinary tract infections following midurethral sling operations in women undergoing hysterectomy SO INTERNATIONAL UROGYNECOLOGY JOURNAL LA English DT Article; Proceedings Paper CT 40th Meeting of the International-Urogynecological-Association CY JUN 11, 2015 CL Nice, FRANCE SP Amer Urogynecol Soc DE Hysterectomy; Midurethral sling; Prolapse operations; TOT; TVT; Urinary tract infection ID RANDOMIZED-CONTROLLED-TRIAL; SURGERY; COMPLICATIONS; PROPHYLAXIS AB Introduction and hypothesis Urinary tract infections (UTIs) are the most common complication following hysterectomy and mid-urethral sling procedures (MUS). As a MUS is often placed at the time of hysterectomy, we sought to determine if the addition of an MUS procedure significantly increases the risk of UTI in the first 30 days following hysterectomy. Methods This retrospective cohort study utilizes the National Surgical Quality Improvement Program (NSQIP) data bank for the years 2006-2012. The database collects data on all enrolled patients preoperatively and in the first 30 days postoperatively.The database was searched using procedural codes for various types of hysterectomies and MUS procedures. We assessed the incidence of postoperative UTIs following hysterectomy (HYST) only, MUS only, and hysterectomy combined with MUS (HYST+MUS). Adjusted logistic regression analyses were performed to evaluate the effects of individual risk factors and models of interaction. Results The NSQIP cohort included 3,757 in the HYST+MUS group, 9,851 in the MUS-only group, and 57,398 in the HYST-only group. The rates of postoperative UTI, which was the most common postoperative morbidity, were 5.3, 3.4, and 2.5 % respectively. Multivariate logistic regression analysis showed a persistent significant increase in rates of UTI (p<0.001) between the MUS+HYST group and the HYST-only group. This significance was not maintained between the MUS-only group and the MUS+HYST group. Conclusions Data from the NSQIP databank indicate that performing an MUS in combination with hysterectomy nearly doubles the risk of postoperative UTI over a hysterectomy alone. C1 [Gehrich, Alan P.; Mehr, Allen A.; Patzwald, Jason R.] Tripler Army Med Ctr, Dept Obstet & Gynecol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. [Lustik, Michael B.] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. RP Gehrich, AP (reprint author), Tripler Army Med Ctr, Dept Obstet & Gynecol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM alan.p.gehrich.mil@mail.mil NR 18 TC 1 Z9 1 U1 0 U2 0 PU SPRINGER LONDON LTD PI LONDON PA 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND SN 0937-3462 EI 1433-3023 J9 INT UROGYNECOL J JI Int. Urogynecol. J. PD MAR PY 2016 VL 27 IS 3 BP 483 EP 490 DI 10.1007/s00192-015-2861-z PG 8 WC Obstetrics & Gynecology; Urology & Nephrology SC Obstetrics & Gynecology; Urology & Nephrology GA DF2OD UT WOS:000371182300021 PM 26467938 ER PT J AU Su, YT Bethel, J Hu, SW AF Su, Yun-Ting Bethel, James Hu, Shuowen TI Octree-based segmentation for terrestrial LiDAR point cloud data in industrial applications SO ISPRS JOURNAL OF PHOTOGRAMMETRY AND REMOTE SENSING LA English DT Article DE Terrestrial LiDAR; Point cloud segmentation; Split and merge; Piping systems; Cylinder detection ID ALGORITHM; IMAGES AB Automated and efficient algorithms to perform segmentation of terrestrial LiDAR data is critical for exploitation of 3D point clouds, where the ultimate goal is CAD modeling of the segmented data. In this work, a novel segmentation technique is proposed, starting with octree decomposition to recursively divide the scene into octants or voxels, followed by a novel split and merge framework that uses graph theory and a series of connectivity analyses to intelligently merge components into larger connected components. The connectivity analysis, based on a combination of proximity, orientation, and curvature connectivity criteria, is designed for the segmentation of pipes, vessels, and walls from terrestrial LiDAR data of piping systems at industrial sites, such as oil refineries, chemical plants, and steel mills. The proposed segmentation method is exercised on two terrestrial LiDAR datasets of a steel mill and a chemical plant, demonstrating its ability to correctly reassemble and segregate features of interest. (C) 2016 International Society for Photogrammetry and Remote Sensing, Inc. (ISPRS). Published by Elsevier B.V. All rights reserved. C1 [Su, Yun-Ting; Bethel, James] Purdue Univ, Sch Civil Engn, Geomat Engn, 550 Stadium Mall Dr, W Lafayette, IN 47907 USA. [Hu, Shuowen] US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RP Su, YT (reprint author), Purdue Univ, Sch Civil Engn, Geomat Engn, 550 Stadium Mall Dr, W Lafayette, IN 47907 USA. EM yunting.su2015@gmail.com NR 34 TC 1 Z9 1 U1 4 U2 22 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0924-2716 EI 1872-8235 J9 ISPRS J PHOTOGRAMM JI ISPRS-J. Photogramm. Remote Sens. PD MAR PY 2016 VL 113 BP 59 EP 74 DI 10.1016/j.isprsjprs.2016.01.001 PG 16 WC Geography, Physical; Geosciences, Multidisciplinary; Remote Sensing; Imaging Science & Photographic Technology SC Physical Geography; Geology; Remote Sensing; Imaging Science & Photographic Technology GA DF7RJ UT WOS:000371555000005 ER PT J AU Pushpakaran, BN Bayne, SB Ogunniyi, AA AF Pushpakaran, Bejoy N. Bayne, Stephen B. Ogunniyi, Aderinto A. TI Physics-based simulation of 4H-SIC DMOSFET structure under inductive switching SO JOURNAL OF COMPUTATIONAL ELECTRONICS LA English DT Article DE Clamped inductive switching; Electro-thermal simulation; Lattice heating; Power DMOSFET; Silicon carbide; Silvaco ATLAS TCAD ID POWER ELECTRONICS; VOLTAGE; DEVICES; DIODES; MOSFET AB The integration of high power silicon carbide (SiC) Metal Oxide Semiconductor Field Effect Transistors (MOSFETs) in today's power systems drives the demand for deeper understanding of the device switching characteristics by way of device simulation. Applications like motor drive require power MOSFETs to drive highly inductive loads which increase the switching power loss by extending the voltage and current crossover, a situation which gets exacerbated by the presence of parasitic inductance. A 2D model of a 1200 V 4H-SiC vertical DMOSFET half-cell was developed using a commercially available TCAD software package to investigate the electro-thermal switching characteristics using clamped inductive switching circuit for ON state drain current density values up to at an ambient lattice temperature of 300 K. Device physics-based models were included to account for carrier mobility, carrier generation and recombination, impact ionization and lattice heating. In order to analyze the areas of localized lattice heating, the lattice temperature distribution was monitored during simulation. The clamped inductive switching circuit simulations were performed with and without the addition of parasitic electrode inductance to observe the difference in switching energy loss. C1 [Pushpakaran, Bejoy N.; Bayne, Stephen B.] Texas Tech Univ, Elect & Comp Engn, 2500 Broadway, Lubbock, TX 79409 USA. [Ogunniyi, Aderinto A.] Army Res Lab, SEDD, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RP Pushpakaran, BN (reprint author), Texas Tech Univ, Elect & Comp Engn, 2500 Broadway, Lubbock, TX 79409 USA. EM bejoy.pushpakaran@ttu.edu OI Pushpakaran, Bejoy/0000-0002-1342-5951 NR 22 TC 1 Z9 1 U1 3 U2 19 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1569-8025 J9 J COMPUT ELECTRON JI J. Comput. Electron. PD MAR PY 2016 VL 15 IS 1 SI SI BP 191 EP 199 DI 10.1007/s10825-015-0766-1 PG 9 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA DF5OU UT WOS:000371402300023 ER PT J AU Gutmann, E Barstad, I Clark, M Arnold, J Rasmussen, R AF Gutmann, Ethan Barstad, Idar Clark, Martyn Arnold, Jeffrey Rasmussen, Roy TI The Intermediate Complexity Atmospheric Research Model (ICAR) SO JOURNAL OF HYDROMETEOROLOGY LA English DT Article DE Models and modeling; Atm/Ocean Structure/ Phenomena; Mountain meteorology; Physical Meteorology and Climatology; Precipitation; Mountain waves; Circulation/ Dynamics; Orographic effects; Applications; Climate change; Regional models ID CLIMATE-CHANGE IMPACTS; OROGRAPHIC PRECIPITATION; WINTER PRECIPITATION; SPATIAL-DISTRIBUTION; UNITED-STATES; AIR-FLOW; IMPLEMENTATION; SIMULATIONS; SENSITIVITY; CALIFORNIA AB With limited computational resources, there is a need for computationally frugal models. This is particularly the case for atmospheric sciences, which have long relied on either simplistic analytical solutions or computationally expensive numerical models. The simpler solutions are inadequate for many problems, while the cost of numerical models makes their use impossible for many problems, most notably high-resolution climate downscaling applications spanning large areas, long time periods, and many global climate projections. Here the Intermediate Complexity Atmospheric Research model (ICAR) is presented to provide a new step along the modeling complexity continuum. ICAR leverages an analytical solution for high-resolution perturbations to wind velocities, in conjunction with numerical physics schemes, that is, advection and cloud microphysics, to simulate the atmosphere. The focus of the initial development of ICAR is for predictions of precipitation, and eventually temperature, humidity, and radiation at the land surface. Comparisons between ICAR and the Weather Research and Forecasting (WRF) Model for simulations over an idealized mountain are presented, as well as among ICAR, WRF, and the Parameter-Elevation Regressions on Independent Slopes Model (PRISM) observation-based product for a year-long simulation over the Colorado Rockies. In the ideal simulations, ICAR matches WRF precipitation predictions across a range of environmental conditions with a coefficient of determination r(2) of 0.92. In the Colorado Rockies, ICAR, WRF, and PRISM show very good agreement, with differences between ICAR and WRF comparable to the differences between WRF and PRISM in the cool season. For these simulations, WRF required 140-800 times more computational resources than ICAR. C1 [Gutmann, Ethan; Clark, Martyn; Rasmussen, Roy] Natl Ctr Atmospher Res, Res Applicat Lab, POB 3000, Boulder, CO 80307 USA. [Barstad, Idar] Uni Res Comp, Bergen, Norway. [Arnold, Jeffrey] US Army Corps Engineers, Climate Preparedness & Resilience Programs, Seattle, WA USA. RP Gutmann, E (reprint author), Natl Ctr Atmospher Res, Res Applicat Lab, POB 3000, Boulder, CO 80307 USA. EM gutmann@ucar.edu RI Gutmann, Ethan/I-5728-2012 OI Gutmann, Ethan/0000-0003-4077-3430 FU U.S. Army Corps of Engineers FX This work was funded in part through a contract from the U.S. Army Corps of Engineers and a cooperative agreement with the U.S. Bureau of Reclamation. The authors thank Levi Brekke and David Raff for early feedback on the utility of such an approach, Andrew Newman and Andreas Prein for helpful discussions on atmospheric dynamics, and Justin Minder for prompting us to think about spatial variations in the linear wind field early on. All data and models used in this work are freely available. NR 53 TC 3 Z9 3 U1 1 U2 11 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 1525-755X EI 1525-7541 J9 J HYDROMETEOROL JI J. Hydrometeorol. PD MAR PY 2016 VL 17 IS 3 BP 957 EP 973 DI 10.1175/JHM-D-15-0155.1 PG 17 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA DF6OF UT WOS:000371474400001 ER PT J AU Wan, C Hu, MY Borodin, O Qian, JF Qin, ZH Zhang, JG Hu, JZ AF Wan, Chuan Hu, Mary Y. Borodin, Oleg Qian, Jiangfeng Qin, Zhaohai Zhang, Ji-Guang Hu, Jian Zhi TI Natural abundance O-17, Li-6 NMR and molecular modeling studies of the solvation structures of lithium bis(fluorosulfonyl)imide/1,2-dimethoxyethane liquid electrolytes SO JOURNAL OF POWER SOURCES LA English DT Article DE Natural abundance O-17 and Li-6 NMR; Molecular modeling studies; Electrolytes; Lithium bis(fluorosulfonyl)imide; 1,2-Dimethoxyethane; Solvation structure ID SOLID-STATE NMR; ION BATTERIES; SUPERCONCENTRATED ELECTROLYTES; TRANSPORT MECHANISM; DYNAMICS; SOLVENTS; METAL; LI+; SIMULATIONS; STABILITY AB Natural abundance O-17 and Li-6 NMR experiments, quantum chemistry and molecular dynamics studies were employed to investigate the solvation structures of Li+ at various concentrations of LiFSI in DME electrolytes. It was found that the chemical shifts of both O-17 and Li-6 changed with the concentration of LiFSI, indicating the changes of solvation structures with concentration. For the quantum chemistry calculations, the coordinated cluster LiFSI(DME)(2) forms at first, and its relative ratio increases with increasing LiFSI concentration to 1 M. Then the solvation structure LiFSI(DME) become the dominant component. As a result, the coordination of forming contact ion pairs between Li+ and FSI- ion increases, but the association between Li+ and DME molecule decreases. Furthermore, at LiFSI concentration of 4 M the solvation structures associated with Li+(FSI-)(2)(DME), Li-2(+)(FSI-)(DME)(4) and (LiFSI)(2)(DME)(3) become the dominant components. For the molecular dynamics simulation, with increasing concentration, the association between DME and Li+ decreases, and the coordinated number of FSI- increases, which is in perfect accord with the DFT results. (C) 2015 Published by Elsevier B.V. C1 [Wan, Chuan; Hu, Mary Y.; Qian, Jiangfeng; Zhang, Ji-Guang; Hu, Jian Zhi] Pacific NW Natl Lab, JCESR, Richland, WA 99354 USA. [Wan, Chuan; Qin, Zhaohai] China Agr Univ, Coll Sci, Beijing 100193, Peoples R China. [Borodin, Oleg] US Army, Electrochem Branch, Sensor & Electron Devices Directorate, Res Lab, Adelphi, MD 20783 USA. RP Hu, JZ (reprint author), Pacific NW Natl Lab, JCESR, Richland, WA 99354 USA. EM Jianzhi.Hu@pnnl.gov RI Hu, Jian Zhi/F-7126-2012; Wan, Chuan/I-4657-2016 OI Wan, Chuan/0000-0002-8226-7619 FU Joint Center for Energy Storage Research (JCESR), an Energy Innovation Hub - U.S. Department of Energy, Office of Science, Basic Energy Sciences (BES); U.S. Department of Energy's (DOE's) Office of Electricity Delivery and Energy Reliability [57558]; DOE's Office of Biological and Environmental Research (BER); Department of Energy [DE-AC05-76RLO1830] FX This work was supported as part of the Joint Center for Energy Storage Research (JCESR), an Energy Innovation Hub funded by the U.S. Department of Energy, Office of Science, Basic Energy Sciences (BES). The NMR sample preparations were supported by the funding from the U.S. Department of Energy's (DOE's) Office of Electricity Delivery and Energy Reliability (OE) (under Contract No. 57558). The NMR, and computational studies were conducted in the William R. Wiley Environmental Molecular Sciences Laboratory (EMSL), a national scientific user facility sponsored by DOE's Office of Biological and Environmental Research (BER) and located at PNNL. PNNL is operated by Battelle for the Department of Energy under Contract DE-AC05-76RLO1830. NR 34 TC 3 Z9 3 U1 14 U2 37 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 EI 1873-2755 J9 J POWER SOURCES JI J. Power Sources PD MAR 1 PY 2016 VL 307 BP 231 EP 243 DI 10.1016/j.jpowsour.2015.12.120 PG 13 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA DE8KD UT WOS:000370884000030 ER PT J AU Fan, XL Zhu, YJ Luo, C Gao, T Suo, LM Liou, SC Xu, K Wang, CS AF Fan, Xiulin Zhu, Yujie Luo, Chao Gao, Tao Suo, Liumin Liou, Sz-Chian Xu, Kang Wang, Chunsheng TI In situ lithiated FeF3/C nanocomposite as high energy conversion-reaction cathode for lithium-ion batteries SO JOURNAL OF POWER SOURCES LA English DT Article DE Lithium-ion battery; Conversion reaction; Iron fluoride; Cathode material; Prelithiation ID METAL FLUORIDE NANOCOMPOSITES; IRON FLUORIDE; ELECTRODE MATERIALS; LI BATTERIES; THIN-FILMS; PERFORMANCE; FABRICATION; INTERCALATION; TRANSPORT; STORAGE AB Transition metal fluorides (such as FeF3 and FeF2) based on conversion chemistry have been considered as a promising alternative to the intercalation cathode materials due to the high capacity and high energy density. However, the critical challenges for these materials come from the absence of Li source in them, and low power density and poor cycling stability. Herein, pre-lithiated FeF3 with extremely small size of Fe and LiF nanoparticles (both similar to 6 nm) homogeneously embedded in the carbon matrix were synthesized using a facile and scalable in situ strategy. Benefited from the ultra-small Fe and LiF nanoparticles, uniform distribution, and intimate contact between the active species and the carbon matrix, the particle-to-particle interfacial resistance and diffusion length for Li and F are dramatically reduced. As a result, a high specific capacity of over 400 mA h g(-1) with a discharge energy density of similar to 700 W h kg(-1) and favorable cycling performance are achieved, making such composite a promising high-capacity cathode for LIBs. Furthermore, the built-in Li source in this composite renders it a drop-in replacement for cathode materials used in the current LIB configurations, thus paving the way for the practical applications in the text generation of high energy density LIBs. (C) 2016 Elsevier B.V. All rights reserved. C1 [Fan, Xiulin; Zhu, Yujie; Luo, Chao; Gao, Tao; Suo, Liumin; Wang, Chunsheng] Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA. [Liou, Sz-Chian] Univ Maryland, Maryland Nanoctr, College Pk, MD 20742 USA. [Xu, Kang] US Army Res Lab, Power & Energy Div, Sensor & Electron Devices Directorate, Electrochem Branch, Adelphi, MD 20783 USA. RP Wang, CS (reprint author), Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA. EM cswang@umd.edu RI Wang, Chunsheng/H-5767-2011 OI Wang, Chunsheng/0000-0002-8626-6381 FU Army Research Laboratory [W911NF1420031]; Maryland NanoCenter; NispLab FX This work was supported by Army Research Laboratory under Award Number W911NF1420031. The authors gratefully acknowledge the support of the Maryland NanoCenter and its NispLab. The highly pure fluorinated solvents were provided by Drs. Ron Hendershot and Joe Sundstrom of Daikin America. NR 41 TC 9 Z9 9 U1 51 U2 134 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 EI 1873-2755 J9 J POWER SOURCES JI J. Power Sources PD MAR 1 PY 2016 VL 307 BP 435 EP 442 DI 10.1016/j.jpowsour.2016.01.004 PG 8 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA DE8KD UT WOS:000370884000052 ER PT J AU Certal, VF Pratas, R Guimaraes, L Lugo, R Tsou, Y Camacho, M Capasso, R AF Certal, Victor F. Pratas, Rui Guimaraes, Lidia Lugo, Rodolfo Tsou, Yungan Camacho, Macario Capasso, Robson TI Awake examination versus DISE for surgical decision making in patients with OSA: A systematic review SO LARYNGOSCOPE LA English DT Review DE DISE; obstructive sleep apnea ID INDUCED SLEEP ENDOSCOPY; UPPER-AIRWAY-OBSTRUCTION; APNEA SYNDROME; SURGERY; EXPERIENCE; MANAGEMENT; MANEUVER; SITES AB ObjectiveTraditionally, upper airway examination is performed while the patient is awake. However, in the past two decades, drug-induced sleep endoscopy (DISE) has been used as a method of tridimensional evaluation of the upper airway during pharmacologically induced sleep. This study aimed to systematically review the evidence regarding the usefulness of DISE compared with that of traditional awake examination for surgical decision making in patients with obstructive sleep apnea (OSA). Data SourcesScopus, PubMed, and Cochrane Library databases were searched. Review MethodsOnly studies with a primary objective of evaluating the usefulness of DISE for surgical decision making in patients with OSA were selected. The included studies directly compared awake examination data with DISE outcome data in terms of possible influences on surgical decision making and operation success. ResultsA total of eight studies with 535 patients were included in this review. Overall, the surgical treatment changed after DISE in 50.24% (standard deviation 8.4) cases. These changes were more frequently associated with structures contributing to hypopharyngeal or laryngeal obstruction. However, these differences do not automatically indicate a higher success rate. ConclusionThis review emphasized the direct impact of DISE compared with that of awake examination on surgical decision making in OSA patients. However, it is also clear that the available published studies lack evidence on the association between this impact and surgical outcomes. Laryngoscope, 126:768-774, 2016 C1 [Certal, Victor F.] Univ Porto, CINTESIS, Ctr Res Hlth Technol & Informat Syst, Rua Campo Alegre 823, P-4100 Oporto, Portugal. [Certal, Victor F.; Pratas, Rui; Guimaraes, Lidia] Hosp CUF, Sleep Med Ctr, Dept Otorhinolaryngol, Oporto, Portugal. [Certal, Victor F.; Pratas, Rui; Guimaraes, Lidia] Hosp Sao Sebastiao, Oporto, Portugal. [Lugo, Rodolfo] Grp Med San Pedro, Dept Otorhinolaryngol, Monterrey, Mexico. [Tsou, Yungan] China Med Univ Hosp, Div Sleep Surg & Med, Dept Otolaryngol, Taichung, Taiwan. [Camacho, Macario] Tripler Army Med Ctr, Dept Otorhinolaryngol, Div Sleep Surg & Med, Honolulu, HI 96859 USA. [Capasso, Robson] Stanford Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Sleep Surg Div, Stanford, CA 94305 USA. RP Certal, VF (reprint author), Hosp CUF Porto, Serv Otorrinolaringol, Estr Circunvalacao 14341, P-4100180 Oporto, Portugal. EM victorcertal@gmail.com RI FMUP, CINTESIS/C-6631-2014; OI FMUP, CINTESIS/0000-0001-7248-2086; Camacho, Macario/0000-0001-9200-9085 NR 41 TC 4 Z9 4 U1 0 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0023-852X EI 1531-4995 J9 LARYNGOSCOPE JI Laryngoscope PD MAR PY 2016 VL 126 IS 3 BP 768 EP 774 DI 10.1002/lary.25722 PG 7 WC Medicine, Research & Experimental; Otorhinolaryngology SC Research & Experimental Medicine; Otorhinolaryngology GA DF3KM UT WOS:000371242800052 PM 26484801 ER PT J AU Rivera, LO Jackson, DD Rivera, MS Murray, E Waardenburg, T Jenkins, K Wahl, D Mitvalsky, LA Hoover, TA AF Rivera, Luis Omar Jackson, Dawnyea D. Rivera, Moira Shaw Murray, Elizabeth Waardenburg, Tiffany Jenkins, Kathryn Wahl, David Mitvalsky, Laura A. Hoover, Todd A. TI BUILDING EFFICIENCY AND QUALITY IN HEALTH EDUCATION The Army Wellness Center Model SO ACSMS HEALTH & FITNESS JOURNAL LA English DT Article DE Primary Prevention; Health Coaching; Behavior Change; Worksite Wellness ID PROMOTION PROGRAMS; OBESITY; WORK; POPULATION C1 [Rivera, Luis Omar] US Army, Inst Publ Hlth, Hlth Promot & Wellness Directorate, Rochester, MI USA. [Rivera, Luis Omar] Army Wellness Ctr, Lawton, OK 73503 USA. [Jackson, Dawnyea D.] US Army, Inst Publ Hlth, Hlth Promot & Wellness Portfolio, Publ Hlth Assessment Program, Rochester, MI USA. [Rivera, Moira Shaw] Contracting Resources Grp, Publ Hlth Evaluat Div, Rochester, MI USA. [Rivera, Moira Shaw; Hoover, Todd A.] US Army, Publ Hlth Ctr Provis, Army Inst Publ Hlth, Rochester, MI USA. [Murray, Elizabeth] Army Wellness Ctr, Carlisle, PA USA. [Waardenburg, Tiffany] Army Wellness Ctr Carlisle Barracks, Carlisle, PA USA. [Jenkins, Kathryn] Vicenza Community, Vicenza, Italy. [Wahl, David] Army Wellness Ctr Bavaria, Vilseck, Germany. [Mitvalsky, Laura A.] US Army, Publ Hlth Ctr Provis, Hlth Promot & Wellness Directorate, Army Inst Publ Hlth, Rochester, MI USA. [Hoover, Todd A.] Army Wellness Ctr Initiat, Rochester, MI USA. RP Rivera, LO (reprint author), US Army, Inst Publ Hlth, Hlth Promot & Wellness Directorate, Rochester, MI USA.; Rivera, LO (reprint author), Army Wellness Ctr, Lawton, OK 73503 USA. FU U.S. Army Public Health Center (Provisional); Oak Ridge Institute for Science and Education FX The views expressed in this article are those of the author(s) and do not necessarily reflect the official policy of the Department of Defense, Department of the Army, U.S. Army Medical Department, or the U.S. Government.; This project was funded by the U.S. Army Public Health Center (Provisional) and the Oak Ridge Institute for Science and Education. NR 11 TC 0 Z9 0 U1 2 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1091-5397 EI 1536-593X J9 ACSMS HEALTH FIT J JI ACSMS Health Fit. J. PD MAR-APR PY 2016 VL 20 IS 2 BP 19 EP 23 PG 5 WC Sport Sciences SC Sport Sciences GA DE2WE UT WOS:000370487100006 ER PT J AU Kuhn, JH Lauck, M Bailey, AL Shchetinin, AM Vishnevskaya, TV Bao, YM Ng, TFF LeBreton, M Schneider, BS Gillis, A Tamoufe, U Diffo, JL Takuo, JM Kondov, NO Coffey, LL Wolfe, ND Delwart, E Clawson, AN Postnikova, E Bollinger, L Lackemeyer, MG Radoshitzky, SR Palacios, G Wada, J Shevtsova, ZV Jahrling, PB Lapin, BA Deriabin, PG Dunowska, M Alkhovsky, SV Rogers, J Friedrich, TC O'Connor, DH Goldberg, TL AF Kuhn, Jens H. Lauck, Michael Bailey, Adam L. Shchetinin, Alexey M. Vishnevskaya, Tatyana V. Bao, Yiming Ng, Terry Fei Fan LeBreton, Matthew Schneider, Bradley S. Gillis, Amethyst Tamoufe, Ubald Diffo, Joseph Le Doux Takuo, Jean Michel Kondov, Nikola O. Coffey, Lark L. Wolfe, Nathan D. Delwart, Eric Clawson, Anna N. Postnikova, Elena Bollinger, Laura Lackemeyer, Matthew G. Radoshitzky, Sheli R. Palacios, Gustavo Wada, Jiro Shevtsova, Zinaida V. Jahrling, Peter B. Lapin, Boris A. Deriabin, Petr G. Dunowska, Magdalena Alkhovsky, Sergey V. Rogers, Jeffrey Friedrich, Thomas C. O'Connor, David H. Goldberg, Tony L. TI Reorganization and expansion of the nidoviral family Arteriviridae SO ARCHIVES OF VIROLOGY LA English DT Article ID SIMIAN HEMORRHAGIC-FEVER; EQUINE ARTERITIS VIRUS; RESPIRATORY SYNDROME VIRUS; SUBGENOMIC MESSENGER-RNAS; ISOLATE ATCC VR-2332; INTERNATIONAL COMMITTEE; STANDARDIZED NOMENCLATURE; TAXONOMIC PROPOSALS; RATIFICATION VOTE; SPECIES LEVEL AB The family Arteriviridae presently includes a single genus Arterivirus. This genus includes four species as the taxonomic homes for equine arteritis virus (EAV), lactate dehydrogenase-elevating virus (LDV), porcine respiratory and reproductive syndrome virus (PRRSV), and simian hemorrhagic fever virus (SHFV), respectively. A revision of this classification is urgently needed to accommodate the recent description of eleven highly divergent simian arteriviruses in diverse African nonhuman primates, one novel arterivirus in an African forest giant pouched rat, and a novel arterivirus in common brushtails in New Zealand. In addition, the current arterivirus nomenclature is not in accordance with the most recent version of the International Code of Virus Classification and Nomenclature. Here we outline an updated, amended, and improved arterivirus taxonomy based on current data. Taxon-specific sequence cut-offs are established relying on a newly established open reading frame 1b phylogeny and pairwise sequence comparison (PASC) of coding-complete arterivirus genomes. As a result, the current genus Arterivirus is replaced by five genera: Equartevirus (for EAV), Rodartevirus (LDV + PRRSV), Simartevirus (SHFV + simian arteriviruses), Nesartevirus (for the arterivirus from forest giant pouched rats), and Dipartevirus (common brushtail arterivirus). The current species Porcine reproductive and respiratory syndrome virus is divided into two species to accommodate the clear divergence of the European and American "types" of PRRSV, both of which now receive virus status. The current species Simian hemorrhagic fever virus is divided into nine species to accommodate the twelve known simian arteriviruses. Non-Latinized binomial species names are introduced to replace all current species names to clearly differentiate them from virus names, which remain largely unchanged. C1 [Kuhn, Jens H.; Clawson, Anna N.; Postnikova, Elena; Bollinger, Laura; Lackemeyer, Matthew G.; Wada, Jiro; Jahrling, Peter B.] NIAID, Integrated Res Facil Ft Detrick IRF Frederick, Div Clin Res, NIH, B-8200 Res Plaza, Frederick, MD 21702 USA. [Friedrich, Thomas C.; Goldberg, Tony L.] Univ Wisconsin, Sch Vet Med, Dept Pathobiol Sci, Madison, WI 53706 USA. [Shchetinin, Alexey M.; Vishnevskaya, Tatyana V.; Deriabin, Petr G.; Alkhovsky, Sergey V.] Minist Hlth Russian Federat, DI Ivanovskii Virol Inst, Fed Res Ctr Epidemiol & Microbiol, Moscow, Russia. [Bao, Yiming] NIH, Informat Engn Branch, Natl Ctr Biotechnol Informat, Natl Lib Med, Bldg 10, Bethesda, MD 20892 USA. [Ng, Terry Fei Fan; Kondov, Nikola O.; Delwart, Eric] Blood Syst Res Inst, San Francisco, CA USA. [LeBreton, Matthew] Mosaic, Yaounde, Cameroon. [LeBreton, Matthew; Schneider, Bradley S.; Gillis, Amethyst; Wolfe, Nathan D.] Metabiota, San Francisco, CA USA. [Tamoufe, Ubald; Diffo, Joseph Le Doux; Takuo, Jean Michel] Global Viral Cameroon, Yaounde, Cameroon. [Radoshitzky, Sheli R.; Palacios, Gustavo] US Army, Med Res Inst Infect Dis, Frederick, MD USA. [Shevtsova, Zinaida V.] Sci Res Inst Expt Pathol & Therapy, Sukhumi, Autonomous Repu, Rep of Georgia. [Lapin, Boris A.] Russian Acad Med Sci, Sci Res Inst Med Primatol, Soci, Russia. [Dunowska, Magdalena] Massey Univ, Inst Vet Anim & Biomed Sci, Palmerston North, New Zealand. [Rogers, Jeffrey] Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX 77030 USA. [Lauck, Michael; Bailey, Adam L.; Friedrich, Thomas C.; O'Connor, David H.; Goldberg, Tony L.] Wisconsin Natl Primate Res Ctr, Madison, WI 53715 USA. [Coffey, Lark L.] Univ Calif Davis, Ctr Vectorborne Dis, Dept Pathol Microbiol & Immunol, Sch Vet Med, Davis, CA 95616 USA. [O'Connor, David H.] Univ Wisconsin, Dept Pathol & Lab Med, Sch Med & Publ Hlth, Madison, WI 53706 USA. RP Kuhn, JH (reprint author), NIAID, Integrated Res Facil Ft Detrick IRF Frederick, Div Clin Res, NIH, B-8200 Res Plaza, Frederick, MD 21702 USA.; Goldberg, TL (reprint author), Univ Wisconsin, Sch Vet Med, Dept Pathobiol Sci, Madison, WI 53706 USA.; Goldberg, TL (reprint author), Wisconsin Natl Primate Res Ctr, Madison, WI 53715 USA. EM kuhnjens@mail.nih.gov; tgoldberg@vetmed.wisc.edu RI Palacios, Gustavo/I-7773-2015; OI Palacios, Gustavo/0000-0001-5062-1938; Shchetinin, Alexey/0000-0003-1842-3899; Schneider, Bradley S/0000-0001-7642-0018; Vishnevskaya, Tatyana/0000-0002-6963-8681; Kuhn, Jens H./0000-0002-7800-6045; Lauck, Michael/0000-0003-2813-3705 FU Battelle Memorial Institute's prime [HHSN272200700016I]; National Institutes of Health (NIH) as part of the joint NIH-NSF Ecology of Infectious Disease program [TW009237, R01 AI077376]; Office of Research Infrastructure Programs (ORIP) [P51OD011106]; Intramural Research Program of the National Institutes of Health; National Library of Medicine FX This work was funded in part through Battelle Memorial Institute's prime contract with the US National Institute of Allergy and Infectious Diseases (NIAID) under Contract No. HHSN272200700016I. Battelle employees involved in this work are: L.B. and J.W. Subcontractors to Battelle Memorial Institute who performed this work are: J.H.K and E.P., employees of Tunnell Government Services, Inc.; A.N.C. the owner of Logos Consulting, Inc.; and M.G.L., an employee of Lovelace Respiratory Research Institute. This work was also funded in part through National Institutes of Health (NIH) grant TW009237 as part of the joint NIH-NSF Ecology of Infectious Disease program, grant R01 AI077376, and by the Office of Research Infrastructure Programs (ORIP) grant P51OD011106. This research was also supported in part by the Intramural Research Program of the National Institutes of Health, National Library of Medicine (Y.B.), and benefited from contributions from the PREDICT project of the United States Agency for International Development (USAID) Emerging Pandemic Threats Program. We thank the Cameroon government for their support during the implementation of this project. NR 59 TC 4 Z9 4 U1 2 U2 5 PU SPRINGER WIEN PI WIEN PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA SN 0304-8608 EI 1432-8798 J9 ARCH VIROL JI Arch. Virol. PD MAR PY 2016 VL 161 IS 3 BP 755 EP 768 DI 10.1007/s00705-015-2672-z PG 14 WC Virology SC Virology GA DF0SR UT WOS:000371049800034 PM 26608064 ER PT J AU Brown, C Griggs, T Keene, T Marra, M Skousen, J AF Brown, Carol Griggs, Thomas Keene, Travis Marra, Mike Skousen, Jeff TI Switchgrass Biofuel Production on Reclaimed Surface Mines: I. Soil Quality and Dry Matter Yield SO BIOENERGY RESEARCH LA English DT Article DE Biomass; Carthage; Cave-in-Rock; Harvest management; Revegetation; Shawnee; Switchgrass fertilization ID BIOMASS PRODUCTION; BIOENERGY PRODUCTION; NITROGEN; USA; FEEDSTOCK; HARVEST; MANAGEMENT; FREQUENCY; LOWLAND; MIDWEST AB Growing food crops for biofuel on productive agricultural lands may become less viable as requirements to feed a growing human population increase. This has increased interest in growing cellulosic biofuel feedstocks on marginal lands. Switchgrass (Panicum virgatum L.), a warm-season perennial, is a viable bioenergy crop candidate because it produces high yields on marginal lands under low fertility conditions. In other studies, switchgrass dry matter (DM) yields on marginal croplands varied from 5.0 to 10.0 Mg ha(-1) annually. West Virginia contains immense areas of reclaimed surface mined lands that could support a switchgrass-based biofuel industry, but yield data on these lands are lacking. Field experiments were established in 2008 to determine yields of three switchgrass cultivars on two West Virginia mine sites. One site reclaimed with topsoil and municipal sludge produced biomass yields of 19.0 Mg DM ha(-1) for Cave-in-Rock switchgrass after the sixth year, almost double the varieties Shawnee and Carthage, at 10.0 and 5.7 Mg ha(-1), respectively. Switchgrass yields on another site with no topsoil were 1.0 Mg ha(-1) after the sixth year, with little variation among cultivars. A second experiment was conducted at two other mine sites with a layer of topsoil over gray overburden. Cave-in-Rock was seeded with fertilizer applications of 0, 34, and 68 kg N-P2O5-K2O ha(-1). After the third year, the no fertilizer treatment averaged biomass yields of 0.3 Mg ha(-1), while responses to the other two rates averaged 1.1 and 2.0 Mg ha(-1), respectively. Fertilization significantly increased yields on reclaimed mine soils. Where mine soil fertility was good, yields were similar to those reported on agricultural soils in the Northeastern USA. C1 [Brown, Carol; Griggs, Thomas; Skousen, Jeff] W Virginia Univ, Div Plant & Soil Sci, Morgantown, WV 26506 USA. [Keene, Travis] Mycogen Seeds, Lancaster, PA 17601 USA. [Marra, Mike] US Army Corps Engn, San Antonio, TX 78258 USA. RP Skousen, J (reprint author), W Virginia Univ, Div Plant & Soil Sci, Morgantown, WV 26506 USA. EM jskousen@wvu.edu FU West Virginia Department of Environmental Protection; NEWBio Northeast Woody/Warm-season Grass Biomass Consortium; Hatch Act at West Virginia University FX This research was funded by the West Virginia Department of Environmental Protection, the NEWBio Northeast Woody/Warm-season Grass Biomass Consortium, and with funds appropriated under the Hatch Act at West Virginia University. Scientific article from the West Virginia Agricultural and Forestry Experiment Station. The authors thank Rick Herd, Brady Gutta, Paul Ziemkiewicz, Ken Ellison, Scott Schumaker, Rodney Mangold, John McHale, Kenny Daniel, George Thornsbury, Rick Adams, Terry Potter, Kermit Fincham, David McMichael, and Marcus McCartney for help with project development, site access, and analysis during the study. NR 33 TC 0 Z9 0 U1 3 U2 13 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1939-1234 EI 1939-1242 J9 BIOENERG RES JI BioEnergy Res. PD MAR PY 2016 VL 9 IS 1 BP 31 EP 39 DI 10.1007/s12155-015-9658-2 PG 9 WC Energy & Fuels; Environmental Sciences SC Energy & Fuels; Environmental Sciences & Ecology GA DE7KV UT WOS:000370816300004 ER PT J AU Nieves, JW Ruffing, JA Zion, M Tendy, S Yavorek, T Lindsay, R Cosman, F AF Nieves, Jeri W. Ruffing, Jamie A. Zion, Marsha Tendy, Susan Yavorek, Trudy Lindsay, Robert Cosman, Felicia TI Eating disorders, menstrual dysfunction, weight change and DMPA use predict bone density change in college-aged women SO BONE LA English DT Article DE Peak bone mass; Menstrual dysfunction; Eating disorders; DMPA; Oral contraceptives; Weight loss ID DIETARY CALCIUM INTAKE; ORAL-CONTRACEPTIVE USE; STRESS-FRACTURE RISK; FEMALE ATHLETE TRIAD; MINERAL DENSITY; PHYSICAL-ACTIVITY; ANOREXIA-NERVOSA; FEMORAL-NECK; YOUNG-ADULTS; MASS AB Introduction: There are limited longitudinal studies that have evaluated bone mineral density (BMD) changes in college-aged women. Our objective was to simultaneously evaluate factors influencing 4-year BMD change. Methods: This was a longitudinal cohort study of healthy, physically active women in the US Military Academy (n = 91; average age = 18.4 years). Assessments over four years included: height, weight, calcium intake, physical fitness, menstrual function (annual number cycles), oral contraceptives (OCs) or depotmedroxyprogesterone acetate (DMPA) use, and eating disorder behavior (Eating Disorder Inventory; (EDI)). BMD was measured annually at the lumbar spine and total hip by dual X-ray absorptiometry and calcaneal BMD by PIXI. Slope of 4 year BMD change at each skeletal site (spine total hip and calcaneus) was calculated for each woman. Results: BMD gains occurred at the spine in 50% and the hip in 36% of women. In unadjusted analyses, spine bone gain was positively related to menstrual cycle frequency (p = 0.04). Spine and hip BMD loss occurred in those using DMPA (p < 0.01) and those with the highest EDI quartile scores (p < 0.05). BMD change was unrelated to OC use. Hip and calcaneus BMD decreased with weight loss (average 4.8 + 2.2 lb/year) as compared to those with stable weight/weight gain (p < 0.05). In multivariable analysis, spine BMD increase was significantly related to African American (AA) race, normal EDI score and normal menses. Hip BMD increase was related to AA race, weight increase and normal menses. DMPA use was associated with spine, hip, and calcaneus bone loss. Conclusion: On average, BMD may modestly increase in college-aged women, in the absence of risk factors. However, risk factors including subclinical eating disorders, weight loss, menstrual dysfunction and DMPA use can have significant detrimental effects on BMD in young healthy physically active women. (C) 2015 Elsevier Inc. All rights reserved. C1 [Nieves, Jeri W.; Ruffing, Jamie A.; Zion, Marsha; Lindsay, Robert; Cosman, Felicia] Helen Hayes Hosp, Clin Res Ctr, Route 9W, W Haverstraw, NY 10993 USA. [Nieves, Jeri W.; Ruffing, Jamie A.; Zion, Marsha; Lindsay, Robert; Cosman, Felicia] Helen Hayes Hosp, Reg Bone Ctr, Route 9W, W Haverstraw, NY 10993 USA. [Lindsay, Robert; Cosman, Felicia] Columbia Univ Coll Phys & Surg, Dept Med, New York, NY USA. [Nieves, Jeri W.; Ruffing, Jamie A.] Columbia Univ, Dept Epidemiol, Mailman Sch Publ Hlth, New York, NY 10027 USA. [Tendy, Susan; Yavorek, Trudy] US Mil Acad, West Point, NY 10996 USA. RP Nieves, JW (reprint author), Helen Hayes Hosp, Clin Res Ctr, Route 9W, W Haverstraw, NY 10993 USA. EM nievesj@helenhayeshosp.org FU U.S. Army Medical Research and Materiel Command [DAMD17-98-1-8539] FX This study was funded by a grant from the U.S. Army Medical Research and Materiel Command; award number DAMD17-98-1-8539. NR 44 TC 1 Z9 1 U1 2 U2 11 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 8756-3282 EI 1873-2763 J9 BONE JI Bone PD MAR PY 2016 VL 84 BP 113 EP 119 DI 10.1016/j.bone.2015.12.054 PG 7 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA DE8VK UT WOS:000370914600014 PM 26746778 ER PT J AU Schiffmacher, EN Becker, JG Lorah, MM Voytek, MA AF Schiffmacher, Emily N. Becker, Jennifer G. Lorah, Michelle M. Voytek, Mary A. TI The effects of co-contaminants and native wetland sediments on the activity and dominant transformation mechanisms of a 1,1,2,2-tetrachloroethane (TeCA)-degrading enrichment culture SO CHEMOSPHERE LA English DT Article DE 1,1,2,2-Tetrachloroethane; Carbon tetrachloride; Tetrachloroethene; Contaminated wetlands; Dehalococcoides; Dehalobacter ID REDUCTIVE DECHLORINATION; CARBON-TETRACHLORIDE; VINYL-CHLORIDE; DEHALOCOCCOIDES-ETHENOGENES; CHLORINATED SOLVENTS; CIS-DICHLOROETHENE; CHLOROFORM; KINETICS; BIOTRANSFORMATION; DICHLOROMETHANE AB Bioremediation strategies, including bioaugmentation with chlorinated ethene-degrading enrichment cultures, have been successfully applied in the cleanup of subsurface environments contaminated with tetrachloroethene (PCE) and/or trichloroethene (TCE). However, these compounds are frequently found in the environment as components of mixtures that may also contain chlorinated ethanes and methanes. Under these conditions, the implementation of bioremediation may be complicated by inhibition effects, particularly when multiple dehalorespirers are present. We investigated the ability of the 1,1,2,2-tetrachloroethane (TeCA)-dechlorinating culture WBC-2 to biotransform TeCA alone, or a mixture of TeCA plus PCE and carbon tetrachloride (CT), in microcosms. The microcosms contained electron donors provided to biostimulate the added culture and sediment collected from a wetland where numerous "hotspots" of contamination with chlorinated solvent mixtures exist. The dominant TeCA biodegradation mechanism mediated by the WBC-2 culture in the microcosms was different in the presence of these wetland sediments than in the sediment-free enrichment culture or in previous WBC-2 bioaugmented microcosms and column tests conducted with wetland sediment collected at nearby sites. The co-contaminants and their daughter products also inhibited TeCA biodegradation by WBC-2. These results highlight the need to conduct biodegradability assays at new sites, particularly when multiple contaminants and dehalorespiring populations are present. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Schiffmacher, Emily N.; Becker, Jennifer G.] Univ Maryland, Dept Environm Sci & Technol, College Pk, MD 20742 USA. [Lorah, Michelle M.] US Geol Survey, MD DE DC Water Sci Ctr, 5522 Res Pk Dr, Catonsville, MD 21228 USA. [Voytek, Mary A.] US Geol Survey, Natl Ctr 430, Reston, VA 20192 USA. [Becker, Jennifer G.] Michigan Technol Univ, Dept Civil & Environm Engn, Houghton, MI 49931 USA. [Schiffmacher, Emily N.] US Army Corps Engineers, Baltimore, MD USA. [Voytek, Mary A.] NASA, Sci Mission Directorate, Washington, DC 20546 USA. RP Becker, JG (reprint author), Michigan Technol Univ, Dept Civil & Environm Engn, Houghton, MI 49931 USA. EM emily.schiffmacher@gmail.com; jgbecker@mtu.edu; mmlorah@usgs.gov; mary.voytek-1@nasa.gov FU United States Geological Survey; U.S. Army Environmental Conservation and Restoration Division Aberdeen Proving Ground; Maryland Water Resources Research Center FX This work was supported, in part, through funding from the United States Geological Survey through a contract with the U.S. Army Environmental Conservation and Restoration Division Aberdeen Proving Ground, and the Maryland Water Resources Research Center, which is sponsored by the United States Geological Survey. Elizabeth J. P. Jones provided the WBC-2 culture and many helpful suggestions and insights throughout this study. Any use of trade, firm, or product names is for descriptive purposes only and does not imply endorsement by the U.S. Government. NR 34 TC 0 Z9 0 U1 3 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 EI 1879-1298 J9 CHEMOSPHERE JI Chemosphere PD MAR PY 2016 VL 147 BP 239 EP 247 DI 10.1016/j.chemosphere.2015.12.033 PG 9 WC Environmental Sciences SC Environmental Sciences & Ecology GA DE7SD UT WOS:000370836100031 PM 26766361 ER PT J AU Boddu, VM Brenner, MW Patel, JS Kumar, A Mantena, PR Tadepalli, T Pramanik, B AF Boddu, Veera M. Brenner, Matthew W. Patel, Jignesh S. Kumar, Ashok Mantena, P. Raju Tadepalli, Tezeswi Pramanik, Brahmananda TI Energy dissipation and high-strain rate dynamic response of E-glass fiber composites with anchored carbon nanotubes SO COMPOSITES PART B-ENGINEERING LA English DT Article DE Mechanical properties; Glass fibres; Nano-structures; Mechanical testing ID BALLISTIC-PROTECTION PERFORMANCE; MECHANICAL-PROPERTIES; POLYMER COMPOSITES; EPOXY COMPOSITE; NANOCOMPOSITES; BEHAVIOR; ARMOR; SCIENCE; SURFACE AB This study explores the mechanical properties of an E-glass fabric composite reinforced with anchored multi-walled carbon nanotubes (CNTs). The CNTs were grown on the E-glass fabric using a floating catalyst chemical vapor deposition procedure. The E-glass fabric with attached CNTs was then incorporated into resin based composites and compared to similar composites without CNTs. Long and short beam bending tests, uniaxial compression measurements for energy dissipation, high strain-rate Split Hopkinson pressure bar measurements, and ballistic performance (V50) tests were performed to characterize the mechanical properties of the CNT composites. The CNT composites showed a reduction in interlaminar shear strength by 25.9%. They also showed an increase in the specific energy absorption by 106% at high strain rates and an increase in energy density dissipation by 643% after 5 cycles at quasi static strain rates. In ballistic V50 tests, the CNT based composites showed a higher V50 value by 11.1%. Due to their reduced weight and energy dissipation properties, the direct growth of CNTs on E-glass fabrics incorporated into composites have potential defense applications such as blast protection. Published by Elsevier Ltd. C1 [Boddu, Veera M.; Brenner, Matthew W.; Patel, Jignesh S.; Kumar, Ashok] US Army, ERDC, CERL, Champaign, IL 61821 USA. [Mantena, P. Raju; Tadepalli, Tezeswi; Pramanik, Brahmananda] Univ Mississippi, Dept Mech Engn, Composite Struct & Nanoengn Res, University, MS 38677 USA. [Tadepalli, Tezeswi] NIT, Dept Civil Engn, Warangal 5060004, TS, India. [Pramanik, Brahmananda] Univ Montana, Montana Tech, Dept Gen Engn, Butte, MT 59701 USA. RP Boddu, VM (reprint author), US Army, ERDC, CERL, Champaign, IL 61821 USA.; Boddu, VM (reprint author), ARS, Plant Polymer Res Unit, Natl Ctr Agr Res Ctr, USDA, 1815 N Univ St, Peoria, IL 61604 USA. EM veera.boddu@ars.usda.gov NR 56 TC 1 Z9 1 U1 10 U2 26 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1359-8368 EI 1879-1069 J9 COMPOS PART B-ENG JI Compos. Pt. B-Eng. PD MAR 1 PY 2016 VL 88 BP 44 EP 54 DI 10.1016/j.compositesb.2015.10.028 PG 11 WC Engineering, Multidisciplinary; Materials Science, Composites SC Engineering; Materials Science GA DE8NT UT WOS:000370893500006 ER PT J AU Liebert, H AF Liebert, Hugh TI THE ACHAEAN LEAGUE AND THE AMERICAN FOUNDING SO HISTORY OF POLITICAL THOUGHT LA English DT Article DE Achaean League; American Founding; James Madison; Polybius; Aristotle; Plato; Confederacy; Confederation; Ancient Confederations; The Federalist Papers; US Constitution; Federalism; Ancient and Modern Political Science; James Monroe; Ratification Debates; American Classicism; Debates in the Federal Convention of 1787; Notes on Ancient and Modern Confederacies AB This paper reassesses the influence of ancient confederacies on the political thought of the American founding. It suggests that James Madison drew inspiration for innovative elements of the American Constitution from the Achaean League. It also claims that attention to Madison's debts, which he tallied in both Federalist no. 18 and the earlier 'Notes on Ancient and Modem Confederacies,' helps us to appreciate what Madison took to be perhaps the most innovative feature of the American founding not necessarily the Constitution that was established, but the manner in which its establishment was recorded and defended. C1 [Liebert, Hugh] US Mil Acad, Dept Social Sci, 607 Cullum Rd, West Point, NY 10996 USA. RP Liebert, H (reprint author), US Mil Acad, Dept Social Sci, 607 Cullum Rd, West Point, NY 10996 USA. EM hugh.liebert@usma.edu NR 52 TC 0 Z9 0 U1 0 U2 1 PU IMPRINT ACADEMIC PI EXETER PA PO BOX 200, EXETER EX5 5YX, DEVON, ENGLAND SN 0143-781X J9 HIST POLIT THOUGHT JI Hist. Polit. Thought PD SPR PY 2016 VL 37 IS 1 BP 57 EP 77 PG 21 WC History SC History GA DE6TT UT WOS:000370767200003 ER PT J AU Jia, M Gingrich, E Wang, H Li, YP Ghandhi, JB Reitz, RD AF Jia, Ming Gingrich, Eric Wang, Hu Li, Yaopeng Ghandhi, Jaal B. Reitz, Rolf D. TI Effect of combustion regime on in-cylinder heat transfer in internal combustion engines SO INTERNATIONAL JOURNAL OF ENGINE RESEARCH LA English DT Article DE Multi-dimensional model; heat transfer loss; combustion regime; reactivity controlled compression ignition; energy balance; empirical heat transfer correlation ID CONTROLLED COMPRESSION IGNITION; DIESEL-ENGINE; TRANSFER COEFFICIENT; CONVENTIONAL DIESEL; TEMPERATURE; SIMULATIONS; DENSITY; MODELS; FLOWS AB A multi-dimensional model was applied to investigate the influence of combustion regimes on heat transfer losses in internal combustion engines. By utilizing improved turbulence and heat transfer sub-models, the combustion and heat transfer characteristics of the engine were satisfactorily reproduced for operation under conventional diesel combustion, homogeneous charge compression ignition, and reactivity controlled compression ignition regimes. The results indicated that the total heat transfer losses of conventional diesel combustion are the largest among the three combustion regimes due to the direct interaction of the high-temperature flame with the piston wall, while the heat transfer losses of reactivity controlled compression ignition are the lowest and nearly are independent of combustion phasing because of the avoidance of high-temperature regions adjacent to the cylinder walls. Compared to conventional diesel combustion, homogeneous charge compression ignition shows more potential for the reduction of exhaust energy and improvement of fuel efficiency. In reactivity controlled compression ignition combustion, the reduction of heat transfer and exhaust losses outweigh its increase in combustion losses and offer the opportunity for further improvement of fuel efficiency. Furthermore, by evaluating the widely used Woschni and Chang et al.'s empirical heat transfer correlations, it was found that both correlations considerably overestimate the heat transfer rate for the reactivity controlled compression ignition regime. It is necessary to improve empirical heat transfer models to take account of the flow and combustion characteristics under various combustion modes. C1 [Jia, Ming; Li, Yaopeng] Dalian Univ Technol, Sch Energy & Power Engn, Dalian 116024, Peoples R China. [Jia, Ming; Gingrich, Eric; Wang, Hu; Ghandhi, Jaal B.; Reitz, Rolf D.] Univ Wisconsin, Engine Res Ctr, Madison, WI USA. [Gingrich, Eric] US Army Tank Automot Res, Ctr Dev & Engn, Warren, MI USA. RP Jia, M (reprint author), Dalian Univ Technol, Sch Energy & Power Engn, Dalian 116024, Peoples R China. EM jiaming@dlut.edu.cn RI Wang, Hu /O-5643-2015 OI Wang, Hu /0000-0002-7486-4763 FU National Natural Science Foundation of China [51176020]; National Basic Research Project of China [2013CB228400] FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was funded by the National Natural Science Foundation of China (Grant No. 51176020) and National Basic Research Project of China (Grant No. 2013CB228400). NR 58 TC 3 Z9 3 U1 5 U2 14 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1468-0874 EI 2041-3149 J9 INT J ENGINE RES JI Int. J. Engine Res. PD MAR PY 2016 VL 17 IS 3 BP 331 EP 346 DI 10.1177/1468087415575647 PG 16 WC Thermodynamics; Engineering, Mechanical; Transportation Science & Technology SC Thermodynamics; Engineering; Transportation GA DE6NI UT WOS:000370750200005 ER PT J AU Shaw, KA Dunoski, BS Mardis, NJ Pacicca, DM AF Shaw, Kenneth Aaron Dunoski, Brian S. Mardis, Neil J. Pacicca, Donna M. TI Combined posterolateral corner and acute anterior cruciate ligament injuries in an adolescent cohort: a magnetic resonance imaging analysis SO INTERNATIONAL ORTHOPAEDICS LA English DT Article DE Anterior cruciate ligament; Posterolateral corner; Magnetic resonance imaging ID YOUNG ATHLETE; OPEN PHYSES; KNEE; RECONSTRUCTION; TEARS AB Purpose Failure of a reconstructed anterior cruciate ligament (ACL) has significant morbidity in the paediatric and adolescent patient population. Untreated concomitant posterolateral corner (PLC) injury is an identified cause of failed ACL reconstruction; however, the injury pattern has yet to be defined for the paediatric population. Methods Magnetic resonance imaging (MRI) studies of the knee performed between 1 January 2009 and 1 January 2013 were retrospectively reviewed. Imaging reports indicating an intra-substance injury of the ACL were reviewed, and all associated injured structures were recorded. Injury patterns were categorised by age, gender, physis status and associated injuries. Logistic regression and chi-square analyses compared ACL disruptions with and without concomitant PLC injuries. Results One hundred and twenty-eight patients (74 boys and 54 girls, average age 15.27 years) sustained an ACL disruption. Concomitant injury to the PLC was seen in 13.3 % of injuries. Associated PLC injuries were significantly associated with lateral meniscus injury and Segond fractures. Lateral meniscus injury was predictive of PLC injury (p= 0.05) upon logistic regression analysis. Conclusion Concomitant PLC injuries were found in 13.3 % of all ACL disruptions on MRI analysis. Lateral meniscus injuries associated with an ACL disruption were predictive of concomitant PLC injury. Combined injury of the ACL and lateral meniscus should prompt close scrutiny to PLC structures. C1 [Shaw, Kenneth Aaron] Dwight D Eisenhower Army Med Ctr, Dept Orthopaed Surg, 300 East Hosp Rd, Ft Gordon, GA 30905 USA. [Dunoski, Brian S.; Mardis, Neil J.] Childrens Mercy Hosp, Dept Radiol, Kansas City, MO 64108 USA. [Pacicca, Donna M.] Childrens Mercy Hosp, Div Orthopaed Surg, Kansas City, MO 64108 USA. RP Shaw, KA (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Orthopaed Surg, 300 East Hosp Rd, Ft Gordon, GA 30905 USA. EM shaw.aaron82@gmail.com OI Shaw, Kenneth/0000-0002-3553-2889 NR 20 TC 1 Z9 1 U1 1 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0341-2695 EI 1432-5195 J9 INT ORTHOP JI Int. Orthop. PD MAR PY 2016 VL 40 IS 3 BP 555 EP 560 DI 10.1007/s00264-015-3026-x PG 6 WC Orthopedics SC Orthopedics GA DF1FM UT WOS:000371084600019 PM 26537394 ER PT J AU Hire, JM Jacobs, JM Bundy, JV DeVine, JG AF Hire, Justin M. Jacobs, Jeremy M. Bundy, Justin V. DeVine, John G. TI Modified Bohlman technique Response SO JOURNAL OF NEUROSURGERY-SPINE LA English DT Letter C1 [Hire, Justin M.; Jacobs, Jeremy M.] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA USA. [Bundy, Justin V.] Doctors Hosp, Augusta Orthoped & Sports Med Specialists, Augusta, GA USA. [DeVine, John G.] Georgia Regents Univ, Augusta Hosp Syst, Augusta, GA USA. RP Hire, JM (reprint author), Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC NEUROLOGICAL SURGEONS PI ROLLING MEADOWS PA 5550 MEADOWBROOK DRIVE, ROLLING MEADOWS, IL 60008 USA SN 1547-5654 EI 1547-5646 J9 J NEUROSURG-SPINE JI J. Neurosurg.-Spine PD MAR PY 2016 VL 24 IS 3 BP 519 EP 519 PG 1 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA DE8VT UT WOS:000370915500032 PM 27358968 ER PT J AU Burgess, E AF Burgess, Edwin TI Court-Martial: How Military Justice Has Shaped America from the Revolution to 9/11 and Beyond. SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin] US Army Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, E (reprint author), US Army Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD MAR 1 PY 2016 VL 141 IS 4 BP 108 EP 108 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA DF1NB UT WOS:000371105400156 ER PT J AU Burgess, E AF Burgess, Edwin TI So Close to Home: A True Story of an American Family's Fight for Survival During World War II. SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin] US Army Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, E (reprint author), US Army Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD MAR 1 PY 2016 VL 141 IS 4 BP 110 EP 110 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA DF1NB UT WOS:000371105400164 ER PT J AU Brum, JR Ignacio-Espinoza, JC Kim, EH Trubl, G Jones, RM Roux, S VerBerkmoes, NC Rich, VI Sullivan, MB AF Brum, Jennifer R. Ignacio-Espinoza, J. Cesar Kim, Eun-Hae Trubl, Gareth Jones, Robert M. Roux, Simon VerBerkmoes, Nathan C. Rich, Virginia I. Sullivan, Matthew B. TI Illuminating structural proteins in viral "dark matter" with metaproteomics SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE viruses; marine; proteins ID SHOTGUN PROTEOMICS; OCEAN; VIRUSES; BACTERIOPHAGES; IDENTIFICATION; GENOME; ENVIRONMENTS; COMMUNITIES; DISCOVERY; SOFTWARE AB Viruses are ecologically important, yet environmental virology is limited by dominance of unannotated genomic sequences representing taxonomic and functional "viral dark matter." Although recent analytical advances are rapidly improving taxonomic annotations, identifying functional darkmatter remains problematic. Here, we apply paired metaproteomics and dsDNA-targeted metagenomics to identify 1,875 virion-associated proteins from the ocean. Over one-half of these proteins were newly functionally annotated and represent abundant and widespread viral metagenome-derived protein clusters (PCs). One primarily unannotated PC dominated the dataset, but structural modeling and genomic context identified this PC as a previously unidentified capsid protein from multiple uncultivated tailed virus families. Furthermore, four of the five most abundant PCs in the metaproteome represent capsid proteins containing the HK97-like protein fold previously found in many viruses that infect all three domains of life. The dominance of these proteins within our dataset, as well as their global distribution throughout the world's oceans and seas, supports prior hypotheses that this HK97-like protein fold is the most abundant biological structure on Earth. Together, these culture-independent analyses improve virion-associated protein annotations, facilitate the investigation of proteins within natural viral communities, and offer a high-throughput means of illuminating functional viral dark matter. C1 [Brum, Jennifer R.; Roux, Simon; Sullivan, Matthew B.] Univ Arizona, Dept Ecol & Evolutionary Biol, Tucson, AZ 85721 USA. [Ignacio-Espinoza, J. Cesar; Sullivan, Matthew B.] Univ Arizona, Dept Mol & Cellular Biol, Tucson, AZ 85721 USA. [Kim, Eun-Hae; Trubl, Gareth; Jones, Robert M.; Rich, Virginia I.; Sullivan, Matthew B.] Univ Arizona, Dept Soil Water & Environm Sci, Tucson, AZ 85721 USA. [VerBerkmoes, Nathan C.] Oak Ridge Natl Lab, Chem Sci Div, Oak Ridge, TN 37831 USA. [Brum, Jennifer R.; Trubl, Gareth; Roux, Simon; Rich, Virginia I.; Sullivan, Matthew B.] Ohio State Univ, Dept Microbiol, Columbus, OH 43210 USA. [Brum, Jennifer R.; Trubl, Gareth; Roux, Simon; Rich, Virginia I.; Sullivan, Matthew B.] Ohio State Univ, Dept Civil Environm & Geodet Engn, Columbus, OH 43210 USA. [Ignacio-Espinoza, J. Cesar] Univ So Calif, Dept Biol Sci, Los Angeles, CA 90089 USA. [Kim, Eun-Hae] Roche Tissue Diagnost, Oro Valley, AZ 85755 USA. [Jones, Robert M.] US Army, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. [VerBerkmoes, Nathan C.] Univ Texas El Paso, Dept Biol Sci, Border Biomed Res Ctr, El Paso, TX 79968 USA. RP Sullivan, MB (reprint author), Univ Arizona, Dept Ecol & Evolutionary Biol, Tucson, AZ 85721 USA.; Sullivan, MB (reprint author), Univ Arizona, Dept Mol & Cellular Biol, Tucson, AZ 85721 USA.; Rich, VI; Sullivan, MB (reprint author), Univ Arizona, Dept Soil Water & Environm Sci, Tucson, AZ 85721 USA.; Rich, VI; Sullivan, MB (reprint author), Ohio State Univ, Dept Microbiol, Columbus, OH 43210 USA.; Rich, VI; Sullivan, MB (reprint author), Ohio State Univ, Dept Civil Environm & Geodet Engn, Columbus, OH 43210 USA. EM virginia.isabel.rich@gmail.com; mbsulli@gmail.com OI Trubl, Gareth/0000-0001-5008-1476; Ignacio Espinoza, J. Cesar/0000-0001-9303-7504 FU University Information Technology Services Research Computing Group; Arizona Research Laboratories Biotechnology Computing; Ford Foundation Postdoctoral Fellowship; Gordon and Betty Moore Foundation [GBMF2631, GBMF3790]; UA Ecosystem Genomics Institute through the UA Technology and Research Initiative Fund; Water, Environmental and Energy Solutions Initiative FX We thank Bonnie Poulos for preparing viral concentrates, Genoscope for viral metagenomic sequencing, members of Tucson Marine Phage Lab for comments on the manuscript, and University Information Technology Services Research Computing Group and the Arizona Research Laboratories Biotechnology Computing for High-Performance Computing Cluster access and support. We thank Kristen Corrier and Manesh Shah of University of Tennessee/Oak Ridge National Laboratory for efforts in filter-aided sample preparation (FASP) preparation of viral samples and MS analyses, and aspects of proteome informatics, respectively. The four viral concentrates were collected as part of exceptional commitment by scientists and sponsors who made the Tara Oceans expedition possible [full list in Brum et al. (6)]. Funding specific to this project was provided by a Ford Foundation Postdoctoral Fellowship (to E.-H.K.), the Gordon and Betty Moore Foundation through Grants GBMF2631 and GBMF3790 (to M.B.S.), and a grant to the UA Ecosystem Genomics Institute through the UA Technology and Research Initiative Fund and the Water, Environmental and Energy Solutions Initiative (to M.B.S. and V.I.R.). This article is contribution 35 of the Tara Oceans Expedition 2009-2012. NR 63 TC 3 Z9 3 U1 6 U2 19 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD MAR 1 PY 2016 VL 113 IS 9 BP 2436 EP 2441 DI 10.1073/pnas.1525139113 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DF2WG UT WOS:000371204500049 PM 26884177 ER PT J AU Collier, ZA Gust, KA Gonzalez-Morales, B Gong, P Wilbanks, MS Linkov, I Perkins, EJ AF Collier, Zachary A. Gust, Kurt A. Gonzalez-Morales, Benette Gong, Ping Wilbanks, Mitchell S. Linkov, Igor Perkins, Edward J. TI A weight of evidence assessment approach for adverse outcome pathways SO REGULATORY TOXICOLOGY AND PHARMACOLOGY LA English DT Article DE Adverse outcome pathway; Weight of evidence; Quantitative AOP; Molecular initiating event; Mode of action; Key event relationships; Bradford Hill criteria ID PROLIFERATOR-ACTIVATED RECEPTOR; GAMMA-AMINOBUTYRIC-ACID; BOBWHITE COLINUS-VIRGINIANUS; BRADFORD-HILL CONSIDERATIONS; PALMITOYLTRANSFERASE I GENE; NUCLEAR HORMONE-RECEPTORS; CEREBELLAR GRANULE CELLS; NORTHERN BOBWHITE; OF-EVIDENCE; PPAR-ALPHA AB The adverse outcome pathway (AOP) is a framework to mechanistically link molecular initiating events to adverse biological outcomes. From a regulatory perspective, it is of crucial importance to determine the confidence for the AOP in question as well as the quality of data available in supporting this evaluation. A weight of evidence approach has been proposed for this task, but many of the existing frameworks for weight of evidence evaluation are qualitative and there is not clear guidance regarding how weight of evidence should be calculated for an AOP. In this paper we advocate the use of a subject matter expertise driven approach for weight of evidence evaluation based on criteria and metrics related to data quality and the strength of causal linkages between key events. As a demonstration, we notionally determine weight of evidence scores for two AOPs: Non-competitive ionotropic GABA receptor antagonism leading to epileptic seizures, and Antagonist-binding and stabilization of a co-repressor to the peroxisome proliferator-activated receptor alpha (PPAR alpha) signaling complex ultimately causing starvation like weight loss. Published by Elsevier Ltd. C1 [Collier, Zachary A.; Gust, Kurt A.; Gong, Ping; Wilbanks, Mitchell S.; Linkov, Igor; Perkins, Edward J.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA. [Gonzalez-Morales, Benette] Univ Puerto Rico, Mayaguez, PR USA. RP Collier, ZA (reprint author), 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM zac4nf@virginia.edu RI Leite, Paulo Emilio/N-3443-2013 OI Leite, Paulo Emilio/0000-0002-1783-1228 FU US Army Environmental Quality/Installations (EQ/I) research program FX This work was funded by the US Army Environmental Quality/Installations (EQ/I) research program. Permission was granted by the Chief of Engineers to publish this material. The views and opinions expressed in this paper are those of the individual authors and not those of the U.S. Army, or other sponsor organizations. NR 102 TC 1 Z9 1 U1 2 U2 16 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0273-2300 EI 1096-0295 J9 REGUL TOXICOL PHARM JI Regul. Toxicol. Pharmacol. PD MAR PY 2016 VL 75 BP 46 EP 57 DI 10.1016/j.yrtph.2015.12.014 PG 12 WC Medicine, Legal; Pharmacology & Pharmacy; Toxicology SC Legal Medicine; Pharmacology & Pharmacy; Toxicology GA DE5NF UT WOS:000370677000006 PM 26724267 ER PT J AU Townsley, E O'Connor, G Cosgrove, C Woda, M Co, M Thomas, SJ Kalayanarooj, S Yoon, IK Nisalak, A Srikiatkhachorn, A Green, S Stephens, HAF Gostick, E Price, DA Carrington, M Alter, G McVicar, DW Rothman, AL Mathew, A AF Townsley, E. O'Connor, G. Cosgrove, C. Woda, M. Co, M. Thomas, S. J. Kalayanarooj, S. Yoon, I. -K. Nisalak, A. Srikiatkhachorn, A. Green, S. Stephens, H. A. F. Gostick, E. Price, D. A. Carrington, M. Alter, G. McVicar, D. W. Rothman, A. L. Mathew, A. TI Interaction of a dengue virus NS1-derived peptide with the inhibitory receptor KIR3DL1 on natural killer cells SO CLINICAL AND EXPERIMENTAL IMMUNOLOGY LA English DT Article DE dengue; HLA; KIR; NK; pathogenesis ID NK-CELLS; DISEASE SEVERITY; HLA-B; ETHNIC THAIS; T-CELLS; ANTIBODY-RESPONSE; INFECTION; ASSOCIATIONS; RECOGNITION; CORRELATE AB Killer immunoglobulin-like receptors (KIRs) interact with human leucocyte antigen (HLA) class I ligands and play a key role in the regulation and activation of NK cells. The functional importance of KIR-HLA interactions has been demonstrated for a number of chronic viral infections, but to date only a few studies have been performed in the context of acute self-limited viral infections. During our investigation of CD8(+) T cell responses to a conserved HLA-B57-restricted epitope derived from dengue virus (DENV) non-structural protein-1 (NS1), we observed substantial binding of the tetrameric complex to non-T/non-B lymphocytes in peripheral blood mononuclear cells (PBMC) from a long-standing clinical cohort in Thailand. We confirmed binding of the NS1 tetramer to CD56(dim) NK cells, which are known to express KIRs. Using depletion studies and KIR-transfected cell lines, we demonstrated further that the NS1 tetramer bound the inhibitory receptor KIR3DL1. Phenotypical analysis of PBMC from HLA-B57(+) subjects with acute DENV infection revealed marked activation of NS1 tetramer-binding natural killer (NK) cells around the time of defervescence in subjects with severe dengue disease. Collectively, our findings indicate that subsets of NK cells are activated relatively late in the course of acute DENV illness and reveal a possible role for specific KIR-HLA interactions in the modulation of disease outcomes. C1 [Townsley, E.; Woda, M.; Co, M.; Srikiatkhachorn, A.; Green, S.; Mathew, A.] Univ Massachusetts, Med Ctr, Div Infect Dis & Immunol, Worcester, MA USA. [O'Connor, G.; Carrington, M.; McVicar, D. W.] Leidos Biomed Res Inc, Frederick Natl Lab Canc Res, Canc & Inflammat Program, Expt Immunol Lab, Frederick, MD USA. [Cosgrove, C.; Carrington, M.; Alter, G.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Ragon Inst MGH MIT & Harvard, Boston, MA USA. [Thomas, S. J.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Kalayanarooj, S.] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand. [Yoon, I. -K.; Nisalak, A.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Stephens, H. A. F.] UCL, Ctr Nephrol & Anthony Nolan Trust, Royal Free Campus, London, England. [Gostick, E.; Price, D. A.] Cardiff Univ, Sch Med, Inst Infect & Immun, Cardiff CF10 3AX, S Glam, Wales. [Price, D. A.] NIAID, Human Immunol Sect, Vaccine Res Ctr, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA. [Rothman, A. L.] Univ Rhode Isl, Inst Immunol & Informat, 825 Chalkstone Ave, Providence, RI 02908 USA. RP Mathew, A (reprint author), Univ Massachusetts, Div Infect Dis & Immunol, Sch Med, S6-862,55 Lake Ave North, Worcester, MA 01655 USA. EM anuja.mathew@umassmed.edu RI Price, David/C-7876-2013 OI Price, David/0000-0001-9416-2737 FU National Institutes of Health (NIH) [P01 AI34533, U19 AI57319, R21 AI113479, P30 DK032520]; Frederick National Laboratory for Cancer Research [HHSN261200800001E]; NIH, Frederick National Laboratory, Center for Cancer Research FX We thank the subjects who generously donated peripheral blood samples for use in our studies, the NIAID Tetramer Core Facility for provision of the B57-NS126-34 tetramer, Brenda Hartman for expert assistance with graphics and Dr Suchitra Nimmannitya and staff at the Queen Sirikit National Institute for Child Health, the Department of Virology, Armed Forces Research Institute of Medical Sciences and the Department of Transfusion Medicine, Siriraj Hospital, for patient recruitment, sample collection and clinical, virological and HLA typing information. This work was funded by the National Institutes of Health (NIH) via Grants P01 AI34533, U19 AI57319 and R21 AI113479 with core support from NIH P30 DK032520 and federal funds from the Frederick National Laboratory for Cancer Research under Contract No. HHSN261200800001E. Additional support was provided by the Intramural Research Program of the NIH, Frederick National Laboratory, Center for Cancer Research. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products or organizations imply endorsement by the US Government. D. A. P. is a Wellcome Trust Senior Investigator. NR 48 TC 2 Z9 2 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0009-9104 EI 1365-2249 J9 CLIN EXP IMMUNOL JI Clin. Exp. Immunol. PD MAR PY 2016 VL 183 IS 3 BP 419 EP 430 DI 10.1111/cei.12722 PG 12 WC Immunology SC Immunology GA DD8NU UT WOS:000370184600011 PM 26439909 ER PT J AU Cornwell, JFM Higgins, ET AF Cornwell, James F. M. Higgins, E. Tory TI Eager Feelings and Vigilant Reasons: Regulatory Focus Differences in Judging Moral Wrongs SO JOURNAL OF EXPERIMENTAL PSYCHOLOGY-GENERAL LA English DT Article DE intuition; reasoning; regulatory focus; moral judgment ID PREVENTION; AVOIDANCE; PROMOTION; JUDGMENTS; DISGUST; FIT; DECISIONS; FOUNDATIONS; INFORMATION; PERFORMANCE AB For over a decade, moral psychologists have been actively researching the processes underlying moral judgments that are made intuitively without reference to an action's concrete harms or injustice, such as the well-known case of nonprocreative, consensual incest. We suggest that the reason some judge such scenarios as wrong (using intuitive feelings) and others do not (using deliberative reasons) is due to an important motivational distinction. Consistent with this view, across 7 studies, we demonstrate that negative judgments of such moral scenarios are more intense when processed in the promotion focus compared to the prevention focus, and that this is due to differences in whether eager (intuitive feelings) versus vigilant (deliberative reasons) means are employed in judging these moral wrongs. By examining both boundary conditions and possible underlying mechanisms for regulatory focus differences in moral judgment intensity, we expand our understanding of the differences between promotion and prevention regarding how proscriptive judgments are processed, while integrating these differences with existing theories in moral psychology. C1 [Cornwell, James F. M.] US Mil Acad, Dept Behav Sci & Leadership, 281 Thayer Hall, West Point, NY 10996 USA. [Higgins, E. Tory] Columbia Univ, Dept Psychol, New York, NY 10027 USA. RP Cornwell, JFM (reprint author), US Mil Acad, Dept Behav Sci & Leadership, 281 Thayer Hall, West Point, NY 10996 USA. EM jamesfcornwell@gmail.com FU National Science Foundation; National Institute of Mental Health [39429] FX We thank John Jost for his helpful comments on an earlier version of this article. We would also like to thank Serena De Stefani, Bradley Swain, and Jay Kent for their assistance in coding participant essays. This research was supported by the National Science Foundation in the form of a Graduate Research Fellowship awarded to James Cornwell. It was also supported by Grant 39429 from the National Institute of Mental Health to E. Tory Higgins NR 66 TC 2 Z9 2 U1 4 U2 24 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0096-3445 EI 1939-2222 J9 J EXP PSYCHOL GEN JI J. Exp. Psychol.-Gen. PD MAR PY 2016 VL 145 IS 3 BP 338 EP 355 DI 10.1037/xge0000136 PG 18 WC Psychology, Experimental SC Psychology GA DE4TO UT WOS:000370623400007 PM 26726912 ER PT J AU Kalantarnia, M Chouinard, L Foltz, S AF Kalantarnia, Maryam Chouinard, Luc Foltz, Stuart TI Objective Procedure for Optimization of Inspection and Testing Strategies for Spillways SO JOURNAL OF INFRASTRUCTURE SYSTEMS LA English DT Article DE Spillway gate system; Unavailability; Inspection and testing; Optimization; Flood; Load rejection; Software application ID COST; RISK AB The function of a spillway gate system is to control the flow of water through an opening for purposes such as flow regulation, flood control, emergency water release during load rejection, and dewatering for maintenance operations, or to remediate or respond to structural deficiencies. A growing problem for dam owners is the aging of such structures. As spillway systems age, more rigorous maintenance, inspection/testing, and repair/replacement of parts are required to ensure their long-term safe operation. Executing these measures may be very costly to dam owners and, if not conducted appropriately, may not have the desired effect on the reliability of the system. The first objective of this paper is to investigate the effect of inspection, testing, repair, and replacement strategies on the availability of spillway gate components. The second objective is to model the availability of the entire spillway gate system under flood and load rejection scenarios to determine the ability of the system as a whole to operate safely under emergency conditions. These two objectives are then used with cost optimization to develop recommendations on the type and frequency of inspections and tests for different types of spillway gate systems. A software application was developed to achieve the objectives by modeling the spillway gate components and system, determining component/system unavailability based on type and frequency of inspections/tests, and obtaining the optimum inspection/testing strategy. (C) 2015 American Society of Civil Engineers. C1 [Kalantarnia, Maryam; Chouinard, Luc] McGill Univ, Montreal, PQ H3A 0G4, Canada. [Foltz, Stuart] US Army, Corps Engineers, ERDC CERL, Chicago, IL 61826 USA. RP Kalantarnia, M (reprint author), McGill Univ, Montreal, PQ H3A 0G4, Canada. EM maryam.kalantarnia@mail.mcgill.ca NR 29 TC 0 Z9 0 U1 3 U2 4 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1076-0342 EI 1943-555X J9 J INFRASTRUCT SYST JI J. Infrastruct. Syst. PD MAR PY 2016 VL 22 IS 1 AR 04015011 DI 10.1061/(ASCE)IS.1943-555X.0000259 PG 12 WC Engineering, Civil SC Engineering GA DE1ZB UT WOS:000370424500001 ER PT J AU Saunders, D Lon, C AF Saunders, David Lon, Chanthap TI Combination therapies for malaria are failing-what next? SO LANCET INFECTIOUS DISEASES LA English DT Editorial Material ID DIHYDROARTEMISININ-PIPERAQUINE FAILURE; CAMBODIA; ARTESUNATE; RESISTANCE C1 [Saunders, David] US Army, Med Mat Dev Act, Ft Detrick, MD USA. [Lon, Chanthap] US Army Med Component, Armed Forces Res Inst Med Sci, Phnom Penh, Cambodia. RP Saunders, D (reprint author), US Army, Med Mat Dev Act, Ft Detrick, MD USA. EM david.l.saunders.mil@mail.mil NR 11 TC 2 Z9 2 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1473-3099 EI 1474-4457 J9 LANCET INFECT DIS JI Lancet Infect. Dis. PD MAR PY 2016 VL 16 IS 3 BP 274 EP 275 DI 10.1016/S1473-3099(15)00525-3 PG 2 WC Infectious Diseases SC Infectious Diseases GA DE4FQ UT WOS:000370585000008 PM 26774241 ER PT J AU Pinsker, JE Kain, C Keller, L Rooks, VJ AF Pinsker, Jordan E. Kain, Conor Keller, Laura Rooks, Veronica J. TI Vitamin D deficiency versus non-accidental trauma: comment on "Rickets or abuse? A histologic comparison of rickets and child abuse-related fractures" SO FORENSIC SCIENCE MEDICINE AND PATHOLOGY LA English DT Letter C1 [Pinsker, Jordan E.] William Sansum Diabet Ctr, 2219 Bath St, Santa Barbara, CA 93105 USA. [Pinsker, Jordan E.; Kain, Conor; Keller, Laura; Rooks, Veronica J.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Pinsker, JE (reprint author), William Sansum Diabet Ctr, 2219 Bath St, Santa Barbara, CA 93105 USA.; Pinsker, JE (reprint author), Tripler Army Med Ctr, Honolulu, HI 96859 USA. EM jpinsker@sansum.org OI Pinsker, Jordan/0000-0003-4080-9034 NR 3 TC 1 Z9 1 U1 0 U2 5 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA SN 1547-769X EI 1556-2891 J9 FORENSIC SCI MED PAT JI Forensic Sci. Med. Pathol. PD MAR PY 2016 VL 12 IS 1 BP 119 EP 120 DI 10.1007/s12024-015-9720-6 PG 2 WC Medicine, Legal; Pathology SC Legal Medicine; Pathology GA DD6ZK UT WOS:000370073100021 PM 26438420 ER PT J AU Chung, KK Rhie, RY Lundy, JB Cartotto, R Henderson, E Pressman, MA Joe, VC Aden, JK Driscoll, IR Faucher, LD McDermid, RC Mlcak, RP Hickerson, WL Jeng, JC AF Chung, Kevin K. Rhie, Ryan Y. Lundy, Jonathan B. Cartotto, Robert Henderson, Elizabeth Pressman, Melissa A. Joe, Victor C. Aden, James K. Driscoll, Ian R. Faucher, Lee D. McDermid, Robert C. Mlcak, Ronald P. Hickerson, William L. Jeng, James C. TI A Survey of Mechanical Ventilator Practices Across Burn Centers in North America SO JOURNAL OF BURN CARE & RESEARCH LA English DT Article ID RESPIRATORY-DISTRESS-SYNDROME; ACUTE LUNG INJURY; FREQUENCY PERCUSSIVE VENTILATION; RANDOMIZED CONTROLLED-TRIAL; END-EXPIRATORY PRESSURE; INHALATION INJURY; OSCILLATORY VENTILATION; TIDAL VOLUMES; TRACHEOSTOMY; METAANALYSIS AB Burn injury introduces unique clinical challenges that make it difficult to extrapolate mechanical ventilator (MV) practices designed for the management of general critical care patients to the burn population. We hypothesize that no consensus exists among North American burn centers with regard to optimal ventilator practices. The purpose of this study is to examine various MV practice patterns in the burn population and to identify potential opportunities for future research. A researcher designed, 24-item survey was sent electronically to 129 burn centers. The (2), Fisher's exact, and Cochran-Mantel-Haenszel tests were used to determine if there were significant differences in practice patterns. We analyzed 46 questionnaires for a 36% response rate. More than 95% of the burn centers reported greater than 100 annual admissions. Pressure support and volume assist control were the most common initial MV modes used with or without inhalation injury. In the setting of Berlin defined mild acute respiratory distress syndrome (ARDS), ARDSNet protocol and optimal positive end-expiratory pressure were the top ventilator choices, along with fluid restriction/diuresis as a nonventilator adjunct. For severe ARDS, airway pressure release ventilation and neuromuscular blockade were the most popular. The most frequently reported time frame for mechanical ventilation before tracheostomy was 2 weeks (25 of 45, 55%); however, all respondents reported in the affirmative that there are certain clinical situations where early tracheostomy is warranted. Wide variations in clinical practice exist among North American burn centers. No single ventilator mode or adjunct prevails in the management of burn patients regardless of pulmonary insult. Movement toward American Burn Association-supported, multicenter studies to determine best practices and guidelines for ventilator management in burn patients is prudent in light of these findings. C1 [Chung, Kevin K.; Rhie, Ryan Y.; Lundy, Jonathan B.; Aden, James K.; Driscoll, Ian R.] US Army, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. [Chung, Kevin K.; Lundy, Jonathan B.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Cartotto, Robert] Sunnybrook Hlth Sci Ctr, Toronto, ON M4N 3M5, Canada. [Henderson, Elizabeth] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Pressman, Melissa A.] Arizona Burn Ctr, Phoenix, AZ USA. [Joe, Victor C.] Univ Calif Irvine, Reg Burn Ctr, Orange, CA USA. [Faucher, Lee D.] Univ Wisconsin Hosp, Madison, WI USA. [McDermid, Robert C.] Univ Alberta, Edmonton, AB, Canada. [Mlcak, Ronald P.] Shriners Hosp Children, Galveston, TX 77550 USA. [Hickerson, William L.] Memphis Burn Ctr, Memphis, TN USA. [Jeng, James C.] Mt Sinai Beth Israel Med Ctr, New York, NY USA. RP Chung, KK (reprint author), US Army, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM Kevin.k.chung.mil@mail.mil FU American Burn Association FX This project was commissioned by the Organization and Delivery of Burn Care Committee and funded in part by the American Burn Association. NR 41 TC 3 Z9 4 U1 1 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1559-047X EI 1559-0488 J9 J BURN CARE RES JI J. Burn Care Res. PD MAR-APR PY 2016 VL 37 IS 2 BP E131 EP E139 DI 10.1097/BCR.0000000000000270 PG 9 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA DD4AZ UT WOS:000369866100005 PM 26135527 ER PT J AU Williams, JF Lundy, JB Chung, KK Chan, RK King, BT Renz, EM Cancio, LC AF Williams, James F. Lundy, Jonathan B. Chung, Kevin K. Chan, Rodney K. King, Booker T. Renz, Evan M. Cancio, Leopoldo C. TI Traumatic Injuries Incidental to Hydraulic Well Fracturing: A Case Series SO JOURNAL OF BURN CARE & RESEARCH LA English DT Article C1 [Williams, James F.; Lundy, Jonathan B.; Chung, Kevin K.; Chan, Rodney K.; King, Booker T.; Renz, Evan M.; Cancio, Leopoldo C.] US Army, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. [Chung, Kevin K.; Renz, Evan M.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Cancio, Leopoldo C.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. RP Chung, KK (reprint author), US Army, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. FU Clinical Trials Task Area, U.S. Army Institute of Surgical Research, Ft Sam Houston, Texas FX This study was supported by the Clinical Trials Task Area, U.S. Army Institute of Surgical Research, Ft Sam Houston, Texas. The authors would like to thank Otilia Sanchez, who provided medical writing services on behalf of the U.S. Army Institute of Surgical Research. NR 14 TC 0 Z9 0 U1 2 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1559-047X EI 1559-0488 J9 J BURN CARE RES JI J. Burn Care Res. PD MAR-APR PY 2016 VL 37 IS 2 BP E188 EP E192 DI 10.1097/BCR.0000000000000219 PG 5 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA DD4AZ UT WOS:000369866100013 PM 25423442 ER PT J AU Araujo, M Gunnemann, S Papadimitriou, S Faloutsos, C Basu, P Swami, A Papalexakis, E Koutra, D AF Araujo, Miguel Guennemann, Stephan Papadimitriou, Spiros Faloutsos, Christos Basu, Prithwish Swami, Ananthram Papalexakis, Evangelos E. Koutra, Danai TI Discovery of "comet" communities in temporal and labeled graphs COM2 SO KNOWLEDGE AND INFORMATION SYSTEMS LA English DT Article DE Community detection; Temporal data; Edge labels; Tensor decomposition ID DECOMPOSITION; NETWORKS AB While the analysis of unlabeled networks has been studied extensively in the past, finding patterns in different kinds of labeled graphs is still an open challenge. Given a large edge-labeled network, e.g., a time-evolving network, how can we find interesting patterns? We propose Com , a novel, fast and incremental tensor analysis approach which can discover communities appearing over subsets of the labels. The method is (a) scalable, being linear on the input size, (b) general, (c) needs no user-defined parameters and (d) effective, returning results that agree with intuition. We apply our method to real datasets, including a phone call network, a computer-traffic network and a flight information network. The phone call network consists of 4 million mobile users, with 51 million edges (phone calls), over 14 days, while the flights dataset consists of 7733 airports and 5995 airline companies flying 67,663 different routes. We show that Com spots intuitive patterns regarding edge labels that carry temporal or other discrete information. Our findings include large "star"-like patterns, near-bipartite cores, as well as tiny groups (five users), calling each other hundreds of times within a few days. We also show that we are able to automatically identify competing airline companies. C1 [Araujo, Miguel; Guennemann, Stephan; Faloutsos, Christos; Papalexakis, Evangelos E.; Koutra, Danai] Carnegie Mellon Univ, iLab, Pittsburgh, PA 15213 USA. [Araujo, Miguel; Guennemann, Stephan; Faloutsos, Christos; Papalexakis, Evangelos E.; Koutra, Danai] Carnegie Mellon Univ, Sch Comp Sci, Pittsburgh, PA 15213 USA. [Araujo, Miguel] Univ Porto, CRACS INESC TEC, P-4100 Oporto, Portugal. [Papadimitriou, Spiros] Rutgers State Univ, New Brunswick, NJ 08903 USA. [Basu, Prithwish] Raytheon BBN Technol, Cambridge, MA USA. [Swami, Ananthram] Army Res Lab, Adelphi, MD USA. [Araujo, Miguel] Univ Porto, Fac Ciencias, Dept Ciencia Comp, P-4100 Oporto, Portugal. RP Araujo, M (reprint author), Carnegie Mellon Univ, iLab, Pittsburgh, PA 15213 USA. EM maraujo@cs.cmu.edu OI Araujo, Miguel/0000-0003-2929-7218 FU National Science Foundation [IIS-1247489, IIS-1217559]; Defense Threat Reduction Agency; Army Research Laboratory; US Army Research Office (ARO); Defense Advanced Research Projects Agency (DARPA) [W911NF-11-C-0088]; Google Focused Research Award; Fundacao para a Ciencia e a Tecnologia (Portuguese Foundation for Science and Technology) through the Carnegie Mellon Portugal Program [SFRH/BD/52362/2013]; ERDF; FCT through the COMPETE Programme [FCOMP-01-0124-FEDER-037281]; German Academic Exchange Service (DAAD); [HDTRA1-10-1-0120]; [W911NF-09-2-0053] FX This material is based upon work supported by the National Science Foundation under Grant Nos. IIS-1247489 and IIS-1217559. Research was sponsored by the Defense Threat Reduction Agency and was accomplished under contract No. HDTRA1-10-1-0120 and also sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement No. W911NF-09-2-0053. Additional funding was provided by the US Army Research Office (ARO) and Defense Advanced Research Projects Agency (DARPA) under Contract No. W911NF-11-C-0088. This work is also partially supported by a Google Focused Research Award, by the Fundacao para a Ciencia e a Tecnologia (Portuguese Foundation for Science and Technology) through the Carnegie Mellon Portugal Program under Grant SFRH/BD/52362/2013, by ERDF and FCT through the COMPETE Programme within project FCOMP-01-0124-FEDER-037281 and by a fellowship within the postdoc program of the German Academic Exchange Service (DAAD). Any opinions, findings and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation, DARPA or other funding parties. The US Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation here on. NR 40 TC 1 Z9 1 U1 3 U2 5 PU SPRINGER LONDON LTD PI LONDON PA 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND SN 0219-1377 EI 0219-3116 J9 KNOWL INF SYST JI Knowl. Inf. Syst. PD MAR PY 2016 VL 46 IS 3 BP 657 EP 677 DI 10.1007/s10115-015-0847-2 PG 21 WC Computer Science, Artificial Intelligence; Computer Science, Information Systems SC Computer Science GA DD4SB UT WOS:000369911800007 ER PT J AU Jia, GF Taflanidis, AA Nadal-Caraballo, NC Melby, JA Kennedy, AB Smith, JM AF Jia, Gaofeng Taflanidis, Alexandros A. Nadal-Caraballo, Norberto C. Melby, Jeffrey A. Kennedy, Andrew B. Smith, Jane M. TI Surrogate modeling for peak or time-dependent storm surge prediction over an extended coastal region using an existing database of synthetic storms SO NATURAL HAZARDS LA English DT Article DE Surrogate model; Kriging; Principal component analysis; Time-dependent output; Storm surge; High-fidelity hurricane surge model ID RESPONSE FUNCTION-APPROACH; HAZARD ASSESSMENT; RISK-ASSESSMENT; WAVE; ATTRIBUTES; SIMULATION; HURRICANES; WIND AB This paper investigates the development of a kriging surrogate model for storm surge prediction utilizing an existing database of high-fidelity, synthetic storms. This surrogate model (metamodel) provides a fast-to-compute mathematical approximation to the input/output relationship of the computationally expensive simulation model that created this database. The implementation is considered over a large coastal region composed of nearshore nodes (locations where storm surge is predicted) and further examines the ability to provide time-series forecasting. This setting creates a high-dimensional output (over a few thousand surge responses) for the surrogate model with anticipated high spatial/temporal correlation. Kriging is considered as a surrogate model, and special attention is given to the appropriate parameterization of the synthetic storms, based on the characteristics of the given database, to determine the input for the metamodel formulation. Principal component analysis (PCA) is integrated in this formulation as a dimension reduction technique to improve computational efficiency, as well as to provide accurate and continuous predictions for time-dependent outputs without the need to introduce time averaging in the time-series forecasting. This is established by leveraging the aforementioned correlation characteristics within the initial database. A range of different implementation choices is examined within the integrated kriging/PCA setting, such as the development of single or multiple metamodels for the different outputs. The metamodel accuracy for inland nodes that have remained dry in some of the storms in the initial database is also examined. The performance of the surrogate modeling approach is evaluated through a case study, utilizing a database of 446 synthetic storms for the Gulf of Mexico (Louisiana coast). The output considered includes time histories for 30 locations over a period of 45.5 h with 92 uniform time steps, as well as peak responses over a grid of 545,635 nearshore nodes. High accuracy and computational efficiency are observed for the proposed implementation, whereas including the prediction error statistics provides estimations with significant safety margins. C1 [Jia, Gaofeng; Taflanidis, Alexandros A.; Kennedy, Andrew B.] Univ Notre Dame, Dept Civil & Environm Engn & Earth Sci, 156 Fitzpatrick Hall, Notre Dame, IN 46556 USA. [Nadal-Caraballo, Norberto C.; Melby, Jeffrey A.; Smith, Jane M.] United States Army Corps Engineers, Ctr Res & Dev, Vicksburg, MS 39180 USA. RP Taflanidis, AA (reprint author), Univ Notre Dame, Dept Civil & Environm Engn & Earth Sci, 156 Fitzpatrick Hall, Notre Dame, IN 46556 USA. EM a.taflanidis@nd.edu RI Kennedy, Andrew/E-4746-2011 OI Kennedy, Andrew/0000-0002-7254-1346 FU US Army Corps of Engineers, Engineer Research and Development Center, Coastal and Hydraulics Laboratory, Flood and Coastal Systems RD Program FX This work has been done under contract with the US Army Corps of Engineers, Engineer Research and Development Center, Coastal and Hydraulics Laboratory, Flood and Coastal Systems R&D Program. This support is gratefully acknowledged. NR 45 TC 1 Z9 1 U1 2 U2 12 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0921-030X EI 1573-0840 J9 NAT HAZARDS JI Nat. Hazards PD MAR PY 2016 VL 81 IS 2 BP 909 EP 938 DI 10.1007/s11069-015-2111-1 PG 30 WC Geosciences, Multidisciplinary; Meteorology & Atmospheric Sciences; Water Resources SC Geology; Meteorology & Atmospheric Sciences; Water Resources GA DD6XT UT WOS:000370068700011 ER PT J AU Qu, HB Costache, MC Inan, S Cowan, A Devore, D Ducheyne, P AF Qu, Haibo Costache, Marius C. Inan, Saadet Cowan, Alan Devore, David Ducheyne, Paul TI Local, Controlled Delivery of Local Anesthetics In Vivo from Polymer - Xerogel Composites SO PHARMACEUTICAL RESEARCH LA English DT Article DE composite; controlled release; local anesthetic; sol-gel ID REGIONAL NERVE BLOCKADE; CONTROLLED-RELEASE; POSTOPERATIVE PAIN; INCISIONAL PAIN; DRUG-RELEASE; RAT MODEL; SOL-GEL; BUPIVACAINE; POLYCARBONATES; MICROSPHERES AB Polymer-xerogel composite materials have been introduced to better optimize local anesthetics release kinetics for the pain management. In a previous study, it was shown that by adjusting various compositional and nano-structural properties of both inorganic xerogels and polymers, zero-order release kinetics over 7 days can be achieved in vitro. In this study, in vitro release properties are confirmed in vivo using a model that tests for actual functionality of the released local anesthetics. Composite materials made with tyrosine-polyethylene glycol(PEG)-derived poly(ether carbonate) copolymers and silica-based sol-gel (xerogel) were synthesized. The in vivo release from the composite controlled release materials was demonstrated by local anesthetics delivery in a rat incisional pain model. The tactile allodynia resulting from incision was significantly attenuated in rats receiving drug-containing composites compared with the control and sham groups for the duration during which natural healing had not yet taken place. The concentration of drug (bupivacaine) in blood is dose dependent and maintained stable up to 120 h post-surgery, the longest time point measured. These in vivo studies show that polymer-xerogel composite materials with controlled release properties represent a promising class of controlled release materials for pain management. C1 [Qu, Haibo; Ducheyne, Paul] Univ Penn, Dept Bioengn, Ctr Bioact Mat & Tissue Engn, Philadelphia, PA 19104 USA. [Costache, Marius C.] Rutgers State Univ, New Jersey Ctr Biomat, Piscataway, NJ 08854 USA. [Inan, Saadet; Cowan, Alan] Temple Univ, Dept Pharmacol, Philadelphia, PA 19140 USA. [Devore, David] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Ducheyne, P (reprint author), Univ Penn, Dept Bioengn, Ctr Bioact Mat & Tissue Engn, Philadelphia, PA 19104 USA. EM ducheyne@seas.upenn.edu FU U.S. Army [W81XWH-07-1-0438] FX This work was supported by U.S. Army contract #W81XWH-07-1-0438. The U.S. Army Medical Research Acquisition Activity, 820 Chandler Street, Fort Detrick MD 21702-5014 is the awarding and administering acquisition office. The content of the manuscript does not necessarily reflect the position or the policy of the Government, and no official endorsement should be inferred. NR 37 TC 0 Z9 0 U1 6 U2 22 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0724-8741 EI 1573-904X J9 PHARM RES-DORDR JI Pharm. Res. PD MAR PY 2016 VL 33 IS 3 BP 729 EP 738 DI 10.1007/s11095-015-1822-z PG 10 WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy SC Chemistry; Pharmacology & Pharmacy GA DD5EV UT WOS:000369946400015 PM 26555665 ER PT J AU Guo, ZR Casem, D Hudspeth, M Nie, X Sun, JZ Chen, WN AF Guo, Zherui Casem, Daniel Hudspeth, Matthew Nie, Xu Sun, Jianzhuo Chen, Weinong TI Transverse compression of two high-performance ballistic fibers SO TEXTILE RESEARCH JOURNAL LA English DT Article DE transverse compression; ballistic fiber; polymer; Kevlar; Dyneema; gold ID MECHANICAL-PROPERTIES; SINGLE-FIBER; PPTA FIBERS AB The method for determining the transverse mechanical response of Kevlar (R) KM2 and Dyneema (R) SK76 fibers was improved upon from previous versions of single fiber compression tests. Two fibers were laid parallel and compressed between two tool steel platens. The new experimental setup ensures that the individual fibers are being compressed evenly along the length and that the platens are parallel during compression. Nominal stress-strain curves were obtained for quasi-static loading of both types of fibers. To evaluate the rate effects on the transverse behavior, high-rate transverse compression experiments were also performed using a miniature Kolsky bar loading on single-fiber specimens to obtain the corresponding stress-strain response of these high performance fibers at high rates of deformation. C1 [Guo, Zherui; Hudspeth, Matthew; Sun, Jianzhuo] Purdue Univ, Sch Aeronaut & Astronaut, 2116 McCormick Rd, W Lafayette, IN 47906 USA. [Casem, Daniel] US Army, Res Lab, Aberdeen Proving Ground, MD USA. [Nie, Xu] Univ N Texas, Dept Mech Engn, Denton, TX 76203 USA. [Chen, Weinong] Purdue Univ, Sch Mat Engn, 2116 McCormick Rd, W Lafayette, IN 47906 USA. RP Guo, ZR (reprint author), Purdue Univ, Sch Aeronaut & Astronaut, 2116 McCormick Rd, W Lafayette, IN 47906 USA.; Guo, ZR (reprint author), Purdue Univ, 2116 McCormick Rd, W Lafayette, IN 47906 USA. EM gzherui@purdue.edu FU Johns Hopkins University ARL MEDE Program's Polymer CMRG FX This work was partially supported by the Johns Hopkins University ARL MEDE Program's Polymer CMRG. NR 10 TC 0 Z9 0 U1 4 U2 14 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0040-5175 EI 1746-7748 J9 TEXT RES J JI Text. Res. J. PD MAR PY 2016 VL 86 IS 5 BP 502 EP 511 DI 10.1177/0040517515592814 PG 10 WC Materials Science, Textiles SC Materials Science GA DD6PV UT WOS:000370047000006 ER PT J AU Lu, XCM Shear, DA Deng-Bryant, Y Leung, LY Wei, G Chen, ZY Tortella, FC AF Lu, Xi-Chun May Shear, Deborah A. Deng-Bryant, Ying Leung, Lai Yee Wei, Guo Chen, Zhiyong Tortella, Frank C. TI Comprehensive Evaluation of Neuroprotection Achieved by Extended Selective Brain Cooling Therapy in a Rat Model of Penetrating Ballistic-Like Brain Injury SO THERAPEUTIC HYPOTHERMIA AND TEMPERATURE MANAGEMENT LA English DT Article ID NONDISRUPTIVE AXONAL INJURY; RANDOMIZED CONTROLLED-TRIAL; POSTTRAUMATIC HYPOTHERMIA; MODERATE HYPOTHERMIA; INTRACEREBRAL HEMORRHAGE; STATUS EPILEPTICUS; MILD HYPOTHERMIA; INFLAMMATION; SEIZURES; TRAUMA AB Brain hypothermia has been considered as a promising alternative to whole-body hypothermia in treating acute neurological disease, for example, traumatic brain injury. Previously, we demonstrated that 2-hours selective brain cooling (SBC) effectively mitigated acute (<= 24 hours postinjury) neurophysiological dysfunction induced by a penetrating ballistic-like brain injury (PBBI) in rats. This study evaluated neuroprotective effects of extended SBC (4 or 8 hours in duration) on sub-acute secondary injuries between 3 and 21 days postinjury (DPI). SBC (34 degrees C) was achieved via extraluminal cooling of rats' bilateral common carotid arteries (CCA). Depending on the experimental design, SBC was introduced either immediately or with a 2- or 4-hour delay after PBBI and maintained for 4 or 8 hours. Neuroprotective effects of SBC were evaluated by measuring brain lesion volume, axonal injury, neuroinflammation, motor and cognitive functions, and post-traumatic seizures. Compared to untreated PBBI animals, 4 or 8 hours SBC treatment initiated immediately following PBBI produced comparable neuroprotective benefits against PBBI-induced early histopathology at 3 DPI as evidenced by significant reductions in brain lesion volume, axonal pathology (beta-amyloid precursor protein staining), neuroinflammation (glial fibrillary acetic protein stained-activated astrocytes and rat major histocompatibility complex class I stained activated microglial cell), and post-traumatic nonconvulsive seizures. In the later phase of the injury (7-21 DPI), significant improvement on motor function (rotarod test) was observed under most SBC protocols, including the 2-hour delay in SBC initiation. However, SBC treatment failed to improve cognitive performance (Morris water maze test) measured 13-17 DPI. The protective effects of SBC on delayed axonal injury (silver staining) were evident out to 14 DPI. In conclusion, the CCA cooling method of SBC produced neuroprotection measured across multiple domains that were evident days/weeks beyond the cooling duration and in the absence of overt adverse effects. These proof-of-concept results suggest that SBC may provide an attractive neuroprotective approach for clinical considerations. C1 [Lu, Xi-Chun May; Shear, Deborah A.; Deng-Bryant, Ying; Leung, Lai Yee; Wei, Guo; Chen, Zhiyong; Tortella, Frank C.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Branch Brain Trauma Neuroprotect & Neurorestorat, 503 Robert Grant Ave, Silver Spring, MD USA. RP Lu, XCM (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Branch Brain Trauma Neuroprotect & Neurorestorat, 503 Robert Grant Ave, Silver Spring, MD USA. EM xi-chun.m.lu.civ@mail.mil FU U.S. Army Medical Research and Material Command, Combat Casualty Care Research Program FX This work was supported by funding provided by the U.S. Army Medical Research and Material Command, Combat Casualty Care Research Program. We would like to thank Ms. Xiaofang Yang for her excellent technical support on these experiments. NR 51 TC 2 Z9 2 U1 3 U2 7 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 2153-7658 EI 2153-7933 J9 THER HYPOTHERMIA TEM JI Ther. Hypothermia Temp. Manag. PD MAR 1 PY 2016 VL 6 IS 1 BP 30 EP 39 DI 10.1089/ther.2015.0017 PG 10 WC Critical Care Medicine SC General & Internal Medicine GA DD5NV UT WOS:000369971800007 PM 26684246 ER PT J AU Krebs, SJ Ananworanich, J AF Krebs, Shelly J. Ananworanich, Jintanat TI Immune activation during acute HIV infection and the impact of early antiretroviral therapy SO CURRENT OPINION IN HIV AND AIDS LA English DT Review DE acute infection; antiretroviral therapy; HIV; immune activation; inflammation ID T-CELL-ACTIVATION; VIRUS TYPE-1 INFECTION; DISEASE PROGRESSION; PREDICT MORTALITY; RHESUS MACAQUES; SIV INFECTION; SET-POINT; C VIRUS; VIREMIA; TH17 AB Purpose of reviewThe purpose of this review is to outline recent data pertaining to mechanisms of immune activation in acute infection and describe new developments that seek to determine if early antiretroviral treatment can mitigate chronic immune activation.Recent findingsFollowing the detection of HIV RNA, highly activated CD8(+) T cells expand and peak approximately 2 weeks following peak viral load whereas levels of proinflammatory soluble markers coincide with a rise in viral load. Immune activation during acute infection is driven by many factors including pyroptosis, replicative capacity of the infecting virus, and loss of Th17 cells within the gut. Early antiretroviral therapy (ART), particularly if initiated in Fiebig I (HIV IgM-), preserved mucosal CD4(+) T cells, possibly preventing the release of microbial products associated with immune activation. Viral reservoirs were restricted by the early initiation of ART, and heightened systemic immune activation was partially prevented compared with chronic HIV infection. A strong correlation was found between the size of the viral reservoir and cellular immune activation.SummaryThe timing of immune activation during acute infection occurs shortly after exposure. Recent studies demonstrated that ART mitigates inflammatory responses, preserves CD4(+) T cells, and limits reservoir seeding if provided early in acute HIV infection. C1 [Krebs, Shelly J.; Ananworanich, Jintanat] Walter Reed Army Inst Res, US Mil HIV Res Program, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. [Krebs, Shelly J.; Ananworanich, Jintanat] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. RP Krebs, SJ (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM skrebs@hivresearch.org FU H.M.J. Foundation for the Advancement of Military Medicine, Inc. [W81XWH-11-2-0174]; US Department of Defense [W81XWH-11-2-0174]; NIH [R01NS084911] FX This work was supported by a cooperative agreement (W81XWH-11-2-0174) between the H.M.J. Foundation for the Advancement of Military Medicine, Inc. and the US Department of Defense. J.A. was partially supported by NIH R01NS084911. NR 43 TC 8 Z9 8 U1 3 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1746-630X EI 1746-6318 J9 CURR OPIN HIV AIDS JI Curr. Opin. HIV AIDS PD MAR PY 2016 VL 11 IS 2 BP 163 EP 172 DI 10.1097/COH.0000000000000228 PG 10 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA DD1AE UT WOS:000369652400006 PM 26599167 ER PT J AU Narkhede, M Thota, S Mosurkal, R Muller, WS Kumar, J AF Narkhede, Mahesh Thota, Sammaiah Mosurkal, Ravi Muller, Wayne S. Kumar, Jayant TI Layer-by-layer assembly of halogen-free polymeric materials on nylon/cotton blend for flame retardant applications SO FIRE AND MATERIALS LA English DT Article DE water soluble polysiloxanes; phosphates; nylon; cotton blends; layer-by-layer coating; flame retardant ID THERMAL-DEGRADATION; COTTON CELLULOSE; NITROGEN; BEHAVIOR; DECOMPOSITION; PHOSPHORUS; MECHANISMS; DEPOSITION; COATINGS; STYRENE AB Thin films of environmentally safe, halogen free, anionic sodium phosphate and cationic polysiloxanes were deposited on a Nyco (1:1 nylon/cotton blend) fabric via layer-by-layer (LbL) assembly to reduce the inherent flammability of Nyco fabric. In the coating process, we used three different polysiloxane materials containing different amine groups including, 35-45% (trimethylammoniummethylphenythyl)-methyl siloxane-55-65% dimethyl siloxane copolymer chloride salt (QMS-435), aminoethylaminopropyl silsesquioxane-methylsilsesquioxane copolymer oligomer (WSA-7021) and aminopropyl silesquioxane oligomers (WSA-991), as a positive polyelectrolyte. Thermo-gravimetric analysis showed that coated fabric has char yield around 40% at 600 degrees C whereas control fabric was completely consumed. The vertical flame test (VFT) on the LbL-coated Nyco fabric was passed with after flame time, 2s, and the char length of 3.81cm. Volatile and nontoxic degradation products of flame retardant-coated fabric were analyzed by pyrolysis gas chromatography mass spectroscopy (Py-GCMS). Surface morphology of coated fabrics and burned fabric residues were studied by scanning electron microscopy. Copyright (c) 2014 John Wiley & Sons, Ltd. C1 [Narkhede, Mahesh] Univ Massachusetts, Dept Plast Engn, Lowell, MA USA. [Narkhede, Mahesh; Thota, Sammaiah; Kumar, Jayant] Univ Massachusetts, Ctr Adv Mat, Lowell, MA USA. [Mosurkal, Ravi; Muller, Wayne S.] US Army, Dev Engn Ctr Natick, Natick Soldier Res, Natick, MA USA. [Kumar, Jayant] Univ Massachusetts, Dept Phys & Appl Phys, Lowell, MA USA. RP Mosurkal, R (reprint author), US Army, Dev Engn Ctr Natick, Natick Soldier Res, Natick, MA USA.; Kumar, J (reprint author), Univ Massachusetts, Dept Phys & Appl Phys, Lowell, MA USA. EM ravi.mosurkal.civ@mail.mil; Jayant_Kumar@uml.edu RI MOSURKAL, RAVI/P-6981-2015 FU US Army Natick Soldier Research Development and Engineering Center (NSRDEC) FX Financial support from US Army Natick Soldier Research Development and Engineering Center (NSRDEC) is gratefully acknowledged. We thank Pearl Yip for Py-GCMS measurements. NR 34 TC 2 Z9 2 U1 10 U2 49 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0308-0501 EI 1099-1018 J9 FIRE MATER JI Fire Mater. PD MAR PY 2016 VL 40 IS 2 BP 206 EP 218 DI 10.1002/fam.2280 PG 13 WC Materials Science, Multidisciplinary SC Materials Science GA DC1WT UT WOS:000369009500003 ER PT J AU Bain, ED Knorr, DB Richardson, AD Masser, KA Yu, J Lenhart, JL AF Bain, Erich D. Knorr, Daniel B., Jr. Richardson, Adam D. Masser, Kevin A. Yu, Jian Lenhart, Joseph L. TI Failure processes governing high-rate impact resistance of epoxy resins filled with core-shell rubber nanoparticles SO JOURNAL OF MATERIALS SCIENCE LA English DT Article ID ELASTOMER-MODIFIED EPOXIES; CROSS-LINK DENSITY; HIGH-STRAIN RATES; TOUGHENING MECHANISMS; FRACTURE-TOUGHNESS; BALLISTIC IMPACT; DEFORMATION-BEHAVIOR; SILICA NANOPARTICLES; ENERGY-DISSIPATION; TRIBLOCK COPOLYMER AB Epoxy resins are classically toughened by rubber additives, but the effectiveness of rubber toughening tends to diminish with increasing strain rate, decreasing temperature, and decreasing matrix ductility. In this study, we demonstrate that low loadings of 100-200-nm core-shell rubber (CSR) particulate additives can improve high strain rate (10(4)-10(5) s(-1)) impact resistance by nearly 200 % for epoxy resins with glass transition temperatures T (g) in a range between 60 and 110 A degrees C, without large reductions in T (g) or stiffness. In addition, CSR additives improve low-temperature impact resistance of the epoxies down to 0 A degrees C. Size and surface chemistry of the CSR particles influence the ballistic response, with 200-nm diameter, weakly bound, and poorly dispersed CSR particles providing the greatest toughening performance at low filler loadings and high rates. Impact resistance for a systematic series of CSR-modified epoxies covers a transition from brittle to tough behavior, where the failure mechanism changes with effective fracture resistance. For brittle resins, failure is dominated by initiation of Hertzian cone fracture which depends strongly on fracture toughness K (IC), while for tough resins, failure is dominated by plastic yield at the impact site and is independent of fracture toughness above a minimum K (IC) value of approximately 1.2-1.5 MPa m(1/2). Interestingly, quasistatic mechanical properties are reasonably effective qualitative predictors of high-rate impact resistance, suggesting that the toughening mechanisms of CSR particles are similar over the rates studied here. The insights gained from this study are valuable for design of next generation adhesives, polymers, and polymer composite matrices for lightweight protective applications. C1 [Bain, Erich D.; Knorr, Daniel B., Jr.; Richardson, Adam D.; Masser, Kevin A.; Yu, Jian; Lenhart, Joseph L.] US Army Res Lab, Aberdeen Proving Ground, MD 20783 USA. RP Lenhart, JL (reprint author), US Army Res Lab, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 20783 USA. EM erich.d.bain.civ@mail.mil; daniel.b.knorr.civ@mail.mil; a.richardson.research@gmail.com; kevin.masser.civ@mail.mil; jian.h.yu.civ@mail.mil; joseph.l.lenhart.civ@mail.mil FU Postgraduate Research Participation Program at the U.S. Army Research Laboratory FX The authors wish to thank Bryan Love for helpful discussions. EDB and ADR acknowledge support from the Postgraduate Research Participation Program at the U.S. Army Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USARL. NR 102 TC 5 Z9 5 U1 15 U2 63 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0022-2461 EI 1573-4803 J9 J MATER SCI JI J. Mater. Sci. PD MAR PY 2016 VL 51 IS 5 BP 2347 EP 2370 DI 10.1007/s10853-015-9544-5 PG 24 WC Materials Science, Multidisciplinary SC Materials Science GA DA3EZ UT WOS:000367680800013 ER PT J AU Oh, SC Wu, YQ Tran, DT Lee, IC Lei, Y Liu, DX AF Oh, Su Cheun Wu, Yiqing Tran, Dat T. Lee, Ivan C. Lei, Yu Liu, Dongxia TI Influences of cation and anion substitutions on oxidative coupling of methane over hydroxyapatite catalysts SO FUEL LA English DT Article DE Hydroxyapatite; Membrane reactor; Anion and cation substitution; Methane; Oxidative coupling ID CALCIUM HYDROXYAPATITE; MEMBRANE REACTOR; CARBONATE; LEAD; CONVERSION; MECHANISM; BIOMATERIALS; CONDUCTION; CHEMICALS; ETHYLENE AB Lead substituted hydroxyapatite (Pb-HAP) has been an active catalyst for oxidative coupling of methane (OCM) reactions. CO32- substituted HAP (HAP-CO3) has showed enhanced oxide ion conductivity than bare HAP in high temperature solid oxide fuel cells. Substitutions for both cations and anions in HAP structure (Pb-HAP-CO3) are promising to integrate the catalytic property of Pb-HAP and oxide ion conductive property of HAP-CO3 into one apatite-based ceramic material that can be manufactured into membrane reactors for possessing CH4 activation and O-2 permeation capabilities for efficient OCM reactions. In this work, the effects of substitutions for both cation (Pb2+) and anion (CO32-) in HAP structure on OCM reactions were studied. The composition and physicochemical properties of HAP catalysts were changed by the cation and anion substitutions, respectively, and as consequences, they influenced the catalytic performances of HAP structure in OCM reactions. The selectivity to C-2 (ethylene and ethane) products increased in the order of HAP-CO3 < HAP < Pb-HAP-CO3 < Pb-HAP, while Pb-HAP-CO3 showed the best stability and comparable C-2 yield (under optimized reaction conditions) to Pb-HAP catalyst. Under different reaction temperature and/or CH4/O-2 ratio in the OCM reactions, the CH4 conversion and C-2 or COx (CO and CO2) selectivity showed a strong dependence on the composition of HAP-based catalysts. The present study forms a basis for understanding of the correlations between the composition, structure, and catalytic performance of HAP and other apatite structured catalysts, which are potential membrane materials for OCM reactions in membrane reactors. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Oh, Su Cheun; Wu, Yiqing; Liu, Dongxia] Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA. [Tran, Dat T.; Lee, Ivan C.] US Army, Res Lab, RDRL SED E, Adelphi, MD 20783 USA. [Lei, Yu] Univ Alabama, Chem & Mat Engn, Huntsville, AL 35899 USA. RP Liu, DX (reprint author), Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA. EM liud@umd.edu RI BM, MRCAT/G-7576-2011; OI Lei, Yu/0000-0002-4161-5568 FU American Chemical Society Petroleum Research Fund - United States (ACS-PRF); National Science Foundation - United States [NSF-CBET 1264599]; Maryland NanoCenter; NispLab; NSF; Department of Energy; MRCAT member institutions; DOE Office of Science by Argonne National Laboratory [DE-AC02-06CH11357] FX The authors gratefully acknowledge financial support from the American Chemical Society Petroleum Research Fund - United States (ACS-PRF) and National Science Foundation - United States (NSF-CBET 1264599). We acknowledge the support of Maryland NanoCenter and its NispLab. The NispLab is supported in part by the NSF as a MRSEC Shared Experimental Facility. MRCAT operations are supported by the Department of Energy and the MRCAT member institutions. This research used resources of the Advanced Photon Source, a U.S. Department of Energy (DOE) Office of Science User Facility operated for the DOE Office of Science by Argonne National Laboratory under Contract No. DE-AC02-06CH11357. NR 44 TC 2 Z9 2 U1 9 U2 64 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0016-2361 EI 1873-7153 J9 FUEL JI Fuel PD MAR 1 PY 2016 VL 167 BP 208 EP 217 DI 10.1016/j.fuel.2015.11.058 PG 10 WC Energy & Fuels; Engineering, Chemical SC Energy & Fuels; Engineering GA CY8IG UT WOS:000366651400023 ER PT J AU Hughes, BH Perkins, LB Yang, TC Skonberg, DI AF Hughes, Brianna H. Perkins, L. Brian Yang, Tom C. Skonberg, Denise I. TI Impact of post-rigor high pressure processing on the physicochemical and microbial shelf-life of cultured red abalone (Haliotis rufescens) SO FOOD CHEMISTRY LA English DT Article DE Abalone; High pressure; Quality; Shelf-life ID HIGH HYDROSTATIC-PRESSURE; REFRIGERATED STORAGE; BIOCHEMICAL-CHANGES; MODIFIED ATMOSPHERE; FISH PRODUCTS; MUSCLE; QUALITY; TRIMETHYLAMINE; TEXTURE; AMINES AB High pressure processing (HPP) of post-rigor abalone at 300 MPa for 10 min extended the refrigerated shelf-life to four times that of unprocessed controls. Shucked abalone meats were processed at 100 or 300 MPa for 5 or 10min, and stored at 2 degrees C for 35 days. Treatments were analyzed for aerobic plate count (APC), total volatile base nitrogen (TVBN), K-value, biogenic amines, color, and texture. APC did not exceed 10(6) and TVBN levels remained below 35 mg/100 g for 35 days for the 300 MPa treatments. No biogenic amines were detected in the 300 MPa treatments, but putrescine and cadaverine were detected in the control and 100 MPa treatments. Color and texture were not affected by HPP or storage time. These results indicate that post-rigor processing at 300 MPa for 10 min can significantly increase refrigerated shelf-life of abalone without affecting chemical or physical quality characteristics important to consumers. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Hughes, Brianna H.; Perkins, L. Brian; Skonberg, Denise I.] Univ Maine, Sch Food & Agr, Orono, ME 04469 USA. [Yang, Tom C.] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA. RP Skonberg, DI (reprint author), Univ Maine, Sch Food & Agr, 5735 Hitchner Hall, Orono, ME 04469 USA. EM Denise.Skonberg@umit.maine.edu FU UMaine ADVANCE Rising Tide Center FX The authors gratefully acknowledge the help and support of Marissa Rublee, Phoebe Hodson, Katie Feeney, Beth Fulton, Chris Mishoe, Richard Lopes, and Mary Scerra, Brad Buckley and The Abalone Farm for providing discounted live abalones, and the UMaine ADVANCE Rising Tide Center for funding. This manuscript is number 3435 of the University of Maine Agricultural and Forest Experiment Station. NR 34 TC 0 Z9 1 U1 7 U2 52 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0308-8146 EI 1873-7072 J9 FOOD CHEM JI Food Chem. PD MAR 1 PY 2016 VL 194 BP 487 EP 494 DI 10.1016/j.foodchem.2015.07.144 PG 8 WC Chemistry, Applied; Food Science & Technology; Nutrition & Dietetics SC Chemistry; Food Science & Technology; Nutrition & Dietetics GA CV4PL UT WOS:000364248900065 PM 26471583 ER PT J AU Bozue, JA Chaudhury, S Amemiya, K Chua, J Cote, CK Toothman, RG Dankmeyer, JL Klimko, CP Wilhelmsen, CL Raymond, JW Zavaljevski, N Reifman, J Wallqvist, A AF Bozue, Joel A. Chaudhury, Sidhartha Amemiya, Kei Chua, Jennifer Cote, Christopher K. Toothman, Ronald G. Dankmeyer, Jennifer L. Klimko, Christopher P. Wilhelmsen, Catherine L. Raymond, Jolynn W. Zavaljevski, Nela Reifman, Jaques Wallqvist, Anders TI Phenotypic Characterization of a Novel Virulence-Factor Deletion Strain of Burkholderia mallei That Provides Partial Protection against Inhalational Glanders in Mice SO FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY LA English DT Article DE Burkholderia mallei; virulence factor; live-attenuated vaccine; glanders; aerosol ID ACTIN-BASED MOTILITY; VI SECRETION; BALB/C MICE; MURINE MACROPHAGES; PSEUDOMALLEI; VACCINE; MELIOIDOSIS; SYSTEM; MUTANT; MODEL AB Burkholderia mallei (Bm) is a highly infectious intracellular pathogen classified as a category B biological agent by the Centers for Disease Control and Prevention. After respiratory exposure, Bm establishes itself within host macrophages before spreading into major organ systems, which can lead to chronic infection, sepsis, and death. Previously, we combined computational prediction of host-pathogen interactions with yeast two-hybrid experiments and identified novel virulence factor genes in Bm, including BMAA0553, BMAA0728 (tssN), and BMAA1865. In the present study, we used recombinant allelic exchange to construct deletion mutants of BMAA0553 and tssN (Delta BMAA0553 and Delta TssN, respectively) and showed that both deletions completely abrogated virulence at doses of >100 times the LD50 of the wild-type Bm strain. Analysis of Delta BMAA0553- and Delta TssN-infected mice showed starkly reduced bacterial dissemination relative to wild-type Bm, and subsequent in vitro experiments characterized pathogenic phenotypes with respect to intracellular growth, macrophage uptake and phagosomal escape, actin-based motility, and multinucleated giant cell formation. Based on observed in vitro and in vivo phenotypes, we explored the use of Delta TssN as a candidate live-attenuated vaccine. Mice immunized with aerosolized Delta TssN showed a 21-day survival rate of 67% after a high-dose aerosol challenge with the wild type Bm ATCC 23344 strain, compared to a 0% survival rate for unvaccinated mice. However, analysis of histopathology and bacterial burden showed that while the surviving vaccinated mice were protected from acute infection, Bm was still able to establish a chronic infection. Vaccinated mice showed a modest IgG response, suggesting a limited potential of Delta TssN as a vaccine candidate, but also showed prolonged elevation of pro-inflammatory cytokines, underscoring the role of cellular and innate immunity in mitigating acute infection in inhalational glanders. C1 [Bozue, Joel A.; Amemiya, Kei; Chua, Jennifer; Cote, Christopher K.; Toothman, Ronald G.; Dankmeyer, Jennifer L.; Klimko, Christopher P.] US Army, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. [Chaudhury, Sidhartha; Zavaljevski, Nela; Reifman, Jaques; Wallqvist, Anders] US Army, Med Res Inst Infect Dis, Telemed Adv Technol Res Ctr, Biotechnol HPC Software Applicat Inst, Ft Detrick, MD 21702 USA. [Wilhelmsen, Catherine L.; Raymond, Jolynn W.] US Army, Med Res Inst Infect Dis, Div Pathol, Ft Detrick, MD 21702 USA. RP Wallqvist, A (reprint author), US Army, Med Res Inst Infect Dis, Telemed Adv Technol Res Ctr, Biotechnol HPC Software Applicat Inst, Ft Detrick, MD 21702 USA. EM sven.a.wallqvist.civ@mail.mil FU U.S. Defense Threat Reduction Agency [CBS.MEDBIO.02.10.13H.021]; U.S. Army Medical Research and Materiel Command, as part of the U.S. Army's Network Science Initiative FX The authors thank Vesna Memisevic for discussions on host virulence factor interactions, David DeShazer for providing the pMo130-Delta BPSS0403 plasmid used for constructing the Delta BMAA0553 strain, and Steven Kern and David Fetterer for statistical analysis of these data. The authors were supported by the U.S. Defense Threat Reduction Agency (www.dtra.mil; award number CBS.MEDBIO.02.10.13H.021) and by the U.S. Army Medical Research and Materiel Command (Ft. Detrick, MD), as part of the U.S. Army's Network Science Initiative. The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U.S. Army or the U.S. Department of Defense. This paper has been approved for public release with unlimited distribution. NR 56 TC 2 Z9 2 U1 1 U2 1 PU FRONTIERS MEDIA SA PI LAUSANNE PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLAND SN 2235-2988 J9 FRONT CELL INFECT MI JI Front. Cell. Infect. Microbiol. PD FEB 26 PY 2016 VL 6 AR 21 DI 10.3389/fcimb.2016.00021 PG 15 WC Immunology; Microbiology SC Immunology; Microbiology GA DE7ZN UT WOS:000370855700001 PM 26955620 ER PT J AU Holmes, WW Keyser, BM Paradiso, DC Ray, R Andres, DK Benton, BJ Rothwell, CC Hoard-Fruchey, HM Dillman, JF Sciuto, AM Anderson, DR AF Holmes, Wesley W. Keyser, Brian M. Paradiso, Danielle C. Ray, Radharaman Andres, Devon K. Benton, Betty J. Rothwell, Cristin C. Hoard-Fruchey, Heidi M. Dillman, James F. Sciuto, Alfred M. Anderson, Dana R. TI Conceptual approaches for treatment of phosgene inhalation-induced lung injury SO TOXICOLOGY LETTERS LA English DT Article DE Phosgene; Inhalation; Whole-body; Mechanism; Survival; Treatment; Toxicity; Mice; Exposure ID SMOOTH-MUSCLE-CELLS; ION-CHANNEL TRPA1; ENDOTHELIAL-CELLS; NITRIC-OXIDE; CALCIUM-CHANNELS; PULMONARY-EDEMA; CARDIOVASCULAR-SYSTEM; COVALENT MODIFICATION; CA2+ CURRENTS; UP-REGULATION AB Toxic industrial chemicals are used throughout the world to produce everyday products such as household and commercial cleaners, disinfectants, pesticides, pharmaceuticals, plastics, paper, and fertilizers. These chemicals are produced, stored, and transported in large quantities, which poses a threat to the local civilian population in cases of accidental or intentional release. Several of these chemicals have no known medical countermeasures for their toxic effects. Phosgene is a highly toxic industrial chemical which was used as a chemical warfare agent in WWI. Exposure to phosgene causes latent, non-cardiogenic pulmonary edema which can result in respiratory failure and death. The mechanisms of phosgene-induced pulmonary injury are not fully identified, and currently there is no efficacious countermeasure. Here, we provide a proposed mechanism of phosgene-induced lung injury based on the literature and from studies conducted in our lab, as well as provide results from studies designed to evaluate survival efficacy of potential therapies following whole-body phosgene exposure in mice. Several therapies were able to significantly increase 24 h survival following an LCt(50-70) exposure to phosgene; however, no treatment was able to fully protect against phosgene-induced mortality. These studies provide evidence that mortality following phosgene toxicity can be mitigated by neuro- and calcium-regulators, antioxidants, phosphodiesterase and endothelin receptor antagonists, angiotensin converting enzymes, and transient receptor potential cation channel inhibitors. However, because the mechanism of phosgene toxicity is multifaceted, we conclude that a single therapeutic is unlikely to be sufficient to ameliorate the multitude of direct and secondary toxic effects caused by phosgene inhalation. Published by Elsevier Ireland Ltd. C1 [Holmes, Wesley W.; Paradiso, Danielle C.; Sciuto, Alfred M.; Anderson, Dana R.] US Army, Med Res Inst Chem Def, Analyt Toxicol Div, 2900 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. [Keyser, Brian M.; Ray, Radharaman; Andres, Devon K.; Benton, Betty J.; Rothwell, Cristin C.; Hoard-Fruchey, Heidi M.; Dillman, James F.] US Army, Med Res Inst Chem Def, Div Res, 2900 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. RP Holmes, WW; Anderson, DR (reprint author), US Army, Med Res Inst Chem Def, Analyt Toxicol Div, 2900 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM wesley.w.holmes.civ@mail.mil; dana.r.anderson.civ@mail.mil OI Andres, Devon/0000-0002-6823-4132 FU NIH/NIAID [Y1-A1-6179-04]; USAMRICD [A120-B.P2009-03] FX Funding: This research was supported by an interagency agreement between NIH/NIAID (Y1-A1-6179-04) and the USAMRICD (A120-B.P2009-03). NR 102 TC 2 Z9 3 U1 2 U2 11 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0378-4274 EI 1879-3169 J9 TOXICOL LETT JI Toxicol. Lett. PD FEB 26 PY 2016 VL 244 BP 8 EP 20 DI 10.1016/j.toxlet.2015.10.010 PG 13 WC Toxicology SC Toxicology GA DD1TJ UT WOS:000369704400003 PM 26562770 ER PT J AU Andres, D Keyser, B Benton, B Melber, A Olivera, D Holmes, W Paradiso, D Anderson, D Ray, R AF Andres, Devon Keyser, Brian Benton, Betty Melber, Ashley Olivera, Dorian Holmes, Wesley Paradiso, Danielle Anderson, Dana Ray, Radharaman TI Transient receptor potential (TRP) channels as a therapeutic target for intervention of respiratory effects and lethality from phosgene SO TOXICOLOGY LETTERS LA English DT Article DE Phosgene; TRP channels; Inhalation; Calcium signaling; Respiratory toxicology; SKF; Therapeutic ID AIRWAY INFLAMMATION; ION CHANNELS; MICE LACKING; LUNG INJURY; DISEASE; HYPERTENSION; MECHANISMS; INHALATION; SENSATION; EXPOSURE AB Phosgene (CG), a toxic inhalation and industrial hazard, causes bronchoconstriction, vasoconstriction and associated pathological effects that could be life threatening. Ion channels of the transient receptor potential (TRP) family have been identified to act as specific chemosensory molecules in the respiratory tract in the detection, control of adaptive responses and initiation of detrimental signaling cascades upon exposure to various toxic inhalation hazards (TIH); their activation due to TIH exposure may result in broncho- and vasoconstriction. We studied changes in the regulation of intracellular free Ca2+ concentration ([Ca2+](i)) in cultures of human bronchial smooth muscle cells (BSMC) and human pulmonary microvascular endothelial cells (HPMEC) exposed to CG (16 ppm, 8 min), using an air/liquid interface exposure system. CG increased [Ca2+](i) (p < 0.05) in both cell types, The CG-induced [Ca2+](i) was blocked (p < 0.05) by two types of TRP channel blockers, SKF-96365, a general TRP channel blocker, and RR, a general TRPV (vanilloid type) blocker, in both BSMC and HPMEC. These effects correlate with the in vivo efficacies of these compounds to protect against lung injury and 24 h lethality from whole body CG inhalation exposure in mice (8-10 ppm x 20 min). Thus the TRP channel mechanism appears to be a potential target for intervention in CG toxicity. Published by Elsevier Ireland Ltd. C1 [Andres, Devon; Keyser, Brian; Benton, Betty; Melber, Ashley; Ray, Radharaman] US Army, Med Res Inst Chem Def, Div Res, Aberdeen Proving Ground, MD 21010 USA. [Olivera, Dorian; Holmes, Wesley; Paradiso, Danielle; Anderson, Dana] US Army, Med Res Inst Chem Def, Analyt Toxicol Div, Aberdeen Proving Ground, MD 21010 USA. RP Andres, D (reprint author), US Army, Med Res Inst Chem Def, Div Res, Aberdeen Proving Ground, MD 21010 USA. EM devon.k.andres.ctr@mail.mil; radharaman.ray.civ@mail.mil OI Andres, Devon/0000-0002-6823-4132 FU NIH/NIAID [Y1-A1-6179-04]; USAMRICD [A120-B.P2009-03]; U.S. Department of Energy; U.S. Army Medical Research and Materiel Command (USAMRMC) FX This research was supported by an interagency agreement between NIH/NIAID (Y1-A1-6179-04) and the USAMRICD (A120-B.P2009-03). Additionally this research was supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Medical Research Institute of Chemical Defense administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and U.S. Army Medical Research and Materiel Command (USAMRMC). NR 41 TC 0 Z9 0 U1 4 U2 13 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0378-4274 EI 1879-3169 J9 TOXICOL LETT JI Toxicol. Lett. PD FEB 26 PY 2016 VL 244 BP 21 EP 27 DI 10.1016/j.toxlet.2015.11.004 PG 7 WC Toxicology SC Toxicology GA DD1TJ UT WOS:000369704400004 PM 26562769 ER PT J AU Zhang, K Balasubramanian, K Ozsdolay, BD Mulligan, CP Khare, SV Zheng, WT Gall, D AF Zhang, K. Balasubramanian, K. Ozsdolay, B. D. Mulligan, C. P. Khare, S. V. Zheng, W. T. Gall, D. TI Growth and mechanical properties of epitaxial NbN(001) films on MgO(001) SO SURFACE & COATINGS TECHNOLOGY LA English DT Article DE NbN; Reactive sputtering; Epitaxy; Hardness; Elastic constant; Density functional theory; Vacancy ID SURFACE MORPHOLOGICAL EVOLUTION; MAGNETRON SPUTTER-DEPOSITION; NITRIDE THIN-FILMS; ELECTRONIC TRANSPORT-PROPERTIES; TRANSITION-METAL NITRIDES; PULSED-LASER DEPOSITION; ENERGY ION-IRRADIATION; SINGLE-CRYSTAL; PHYSICAL-PROPERTIES; NIOBIUM NITRIDE AB NbNx layers were deposited by reactive magnetron sputtering on MgO(001) substrates in 0.67 Pa pure N-2 at T-s = 600-1000 degrees C. T-s >= 800 degrees C leads to epitaxial layers with a cube-on-cube relationship to the substrate: (001)(NbN) parallel to(001)(MgO) and [100](NbN)parallel to[100](MgO). The layers are nearly stoichiometric with x = 0.95-0.98 for T-s <= 800 degrees C, but become nitrogen deficient with x = 0.81 and 0.91 for T-s = 900 and 1000 degrees C. X-ray diffraction reciprocal space maps indicate a small in-plane compressive strain of-0.0008 +/- 0.0004 for epitaxial layers, and a relaxed lattice constant that decreases from 4372 A for x = 0.81 to 4363 A for x = 0.98. This unexpected trend is attributed to increasing Nb and decreasing N vacancy concentrations, as quantified by first-principles calculations of the lattice parameter vs. point defect concentration, and consistent with the relatively small calculated formation energies for N and Nb vacancies of 1.00 and-0.67 eV at 0 K and-0.53 and 0.86 eV at 1073 K, respectively. The N-deficient NbN0.81(001) layer exhibits the highest crystalline quality with in-plane and out-of-plane x-ray coherence lengths of 4.5 and 13.8 nm, attributed to a high Nb-adatom diffusion on an N-deficient growth front. However, it also contains inclusions of hexagonal NbN grains which lead to a relatively high measured hardness H = 28.0 +/- 5.1 GPa and elastic modulus E = 406 +/- 70 GPa. In contrast, the nearly stoichiometric phase-pure epitaxial cubic NbN0.98(001) layer has a H = 17.8 +/- 0.7 GPa and E = 315 +/- 13 GPa. The latter value is slightly smaller than 335 and 361 GPa, the isotropic elastic modulus and the [100]-indentation modulus, respectively, predicted for NbN from the calculated c(11) = 641 GPa, c(12) = 140 GPa, and c(44) = 78 GPa. The electrical resistivity ranges from 171 to 437 mu Omega cm at room temperature and 155-646 mu Omega cm at 77 K, suggesting carrier localization due to disorder from vacancies and crystalline defects. (C) 2016 Elsevier B.V. All rights reserved. C1 [Zhang, K.; Zheng, W. T.] Jilin Univ, MOE, Dept Mat Sci, Key Lab Mobile Mat, Changchun 130012, Peoples R China. [Zhang, K.; Zheng, W. T.] Jilin Univ, State Key Lab Superhard Mat, Changchun 130012, Peoples R China. [Zhang, K.; Balasubramanian, K.; Ozsdolay, B. D.; Mulligan, C. P.; Gall, D.] Rensselaer Polytech Inst, Dept Mat Sci & Engn, Troy, NY 12180 USA. [Mulligan, C. P.] US Army, Armament Res Dev & Engn Ctr, Benet Labs, Watervliet, NY 12189 USA. [Khare, S. V.] Univ Toledo, Dept Phys & Astron, 2801 W Bancroft St, Toledo, OH 43606 USA. RP Gall, D (reprint author), Rensselaer Polytech Inst, Dept Mat Sci & Engn, Troy, NY 12180 USA. EM galld@rpi.edu RI Gall, Daniel/B-1060-2008; ZHANG, Kan/D-1703-2010; OI Gall, Daniel/0000-0002-5762-9307; ZHANG, Kan/0000-0003-1354-2784; zheng, weitao/0000-0002-9028-278X FU National Science Foundation [1309490, 1537984, 1234777, 1234872]; Chinese Scholarship Council FX The authors acknowledge support by the National Science Foundation under Grant Nos. 1309490, 1537984, 1234777, and 1234872, and computational resources from the Computational Center for Nanotechnology Innovations at RPI. Kan Zhang thanks the Chinese Scholarship Council for financial support. NR 93 TC 2 Z9 3 U1 15 U2 43 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0257-8972 J9 SURF COAT TECH JI Surf. Coat. Technol. PD FEB 25 PY 2016 VL 288 BP 105 EP 114 DI 10.1016/j.surfcoat.2016.01.009 PG 10 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA DF7PE UT WOS:000371549200013 ER PT J AU Muldoon, SF Bridgeford, EW Bassett, DS AF Muldoon, Sarah Feldt Bridgeford, Eric W. Bassett, Danielle S. TI Small-World Propensity and Weighted Brain Networks SO SCIENTIFIC REPORTS LA English DT Article ID COMPLEX NETWORKS; FUNCTIONAL CONNECTIVITY; COMMUNITY STRUCTURE; PREFRONTAL CORTEX; ORGANIZATION; SCHIZOPHRENIA; NEURODEVELOPMENT; ARCHITECTURE; MODEL AB Quantitative descriptions of network structure can provide fundamental insights into the function of interconnected complex systems. Small-world structure, diagnosed by high local clustering yet short average path length between any two nodes, promotes information flow in coupled systems, a key function that can differ across conditions or between groups. However, current techniques to quantify small-worldness are density dependent and neglect important features such as the strength of network connections, limiting their application in real-world systems. Here, we address both limitations with a novel metric called the Small-World Propensity (SWP). In its binary instantiation, the SWP provides an unbiased assessment of small-world structure in networks of varying densities. We extend this concept to the case of weighted brain networks by developing (i) a standardized procedure for generating weighted small-world networks, (ii) a weighted extension of the SWP, and (iii) a method for mapping observed brain network data onto the theoretical model. In applying these techniques to compare realworld brain networks, we uncover the surprising fact that the canonical biological small-world network, the C. elegans neuronal network, has strikingly low SWP. These metrics, models, and maps form a coherent toolbox for the assessment and comparison of architectural properties in brain networks. C1 [Muldoon, Sarah Feldt; Bridgeford, Eric W.; Bassett, Danielle S.] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA. [Muldoon, Sarah Feldt] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Muldoon, Sarah Feldt] SUNY Buffalo, Dept Math, Buffalo, NY 14260 USA. [Muldoon, Sarah Feldt] SUNY Buffalo, Computat & Data Enabled Sci & Engn Program, Buffalo, NY 14260 USA. [Bridgeford, Eric W.] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD 21218 USA. [Bassett, Danielle S.] Univ Penn, Dept Elect & Syst Engn, Philadelphia, PA 19104 USA. RP Bassett, DS (reprint author), Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA.; Bassett, DS (reprint author), Univ Penn, Dept Elect & Syst Engn, Philadelphia, PA 19104 USA. EM dsb@seas.upenn.edu OI Muldoon, Sarah/0000-0002-2830-9291 FU John D. and Catherine T. MacArthur Foundation; Alfred P. Sloan Foundation; Army Research Laboratory; Army Research Office [W911NF-10-2-0022, W911NF-14-1-0679]; National Institute of Mental Health [2-R01-DC-009209-11]; National Institute of Child Health and Human Development [1R01HD086888-01]; Office of Naval Research; National Science Foundation [BCS-1441502, BCS-1430087] FX DSI data was collected and preprocessed by Matthew Cieslak and Scott Grafton, in the Department of Psychological and Brain Sciences at the University of California, Santa Barbara. This work was supported by the John D. and Catherine T. MacArthur Foundation, the Alfred P. Sloan Foundation, the Army Research Laboratory and the Army Research Office through contract numbers W911NF-10-2-0022 and W911NF-14-1-0679, the National Institute of Mental Health (2-R01-DC-009209-11), the National Institute of Child Health and Human Development (1R01HD086888-01), the Office of Naval Research, and the National Science Foundation (BCS-1441502 and BCS-1430087). NR 67 TC 7 Z9 7 U1 7 U2 17 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD FEB 25 PY 2016 VL 6 AR 22057 DI 10.1038/srep22057 PG 13 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DE7FE UT WOS:000370800000001 PM 26912196 ER PT J AU Echevarria, AJ AF Echevarria, Antulio J., II TI Rediscovering US Military Strategy: A Role for Doctrine SO JOURNAL OF STRATEGIC STUDIES LA English DT Article DE Doctrine; Military Strategy; RMA; Afghanistan; Transformation AB This article argues that US military doctrine, and by extension that of most Western militaries, missed an opportunity in the period following the Cold War to rediscover the many types of military strategies employed to good effect before the industrial-age wars of the twentieth century. This missed opportunity resulted in Coalition forces having to relearn many of those strategies through costly trial and error in Iraq and Afghanistan. C1 [Echevarria, Antulio J., II] US Army War Coll, Carlisle, PA USA. [Echevarria, Antulio J., II] US Army War Coll, Res, Carlisle, PA USA. RP Echevarria, AJ (reprint author), US Army War Coll, Carlisle, PA USA. EM ajech2@yahoo.com NR 54 TC 0 Z9 0 U1 1 U2 1 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0140-2390 EI 1743-937X J9 J STRATEGIC STUD JI J. Strateg. Stud. PD FEB 23 PY 2016 VL 39 IS 2 SI SI BP 231 EP 245 DI 10.1080/01402390.2015.1115035 PG 15 WC International Relations; Political Science SC International Relations; Government & Law GA DG6LR UT WOS:000372196500006 ER PT J AU Miller, OD Polimeridis, AG Reid, MTH Hsu, CW DeLacy, BG Joannopoulos, JD Soljacic, M Johnson, SG AF Miller, Owen D. Polimeridis, Athanasios G. Reid, M. T. Homer Hsu, Chia Wei DeLacy, Brendan G. Joannopoulos, John D. Soljacic, Marin Johnson, Steven G. TI Fundamental limits to optical response in absorptive systems SO OPTICS EXPRESS LA English DT Article ID ALTERNATIVE PLASMONIC MATERIALS; 2-COMPONENT COMPOSITE-MATERIAL; SINGULARITY EXPANSION METHOD; ENHANCED RAMAN-SCATTERING; VOLUME INTEGRAL-EQUATION; CONTROLLED RANDOM SEARCH; RADIATIVE HEAT-TRANSFER; SPONTANEOUS EMISSION; ELECTROMAGNETIC SCATTERING; PHYSICAL LIMITATIONS AB At visible and infrared frequencies, metals show tantalizing promise for strong subwavelength resonances, but material loss typically dampens the response. We derive fundamental limits to the optical response of absorptive systems, bounding the largest enhancements possible given intrinsic material losses. Through basic conservation-of-energy principles, we derive geometry-independent limits to per-volume absorption and scattering rates, and to local-density-of-states enhancements that represent the power radiated or expended by a dipole near a material body. We provide examples of structures that approach our absorption and scattering limits at any frequency; by contrast, we find that common "antenna" structures fall far short of our radiative LDOS bounds, suggesting the possibility for significant further improvement. Underlying the limits is a simple metric, vertical bar x vertical bar(2)/Im x for a material with susceptibility x, that enables broad technological evaluation of lossy materials across optical frequencies. (C) 2016 Optical Society of America C1 [Miller, Owen D.; Reid, M. T. Homer; Johnson, Steven G.] MIT, Dept Math, Cambridge, MA 02139 USA. [Polimeridis, Athanasios G.] Skolkovo Inst Sci & Technol, Skolkovo 143025, Moscow Region, Russia. [Hsu, Chia Wei] Yale Univ, Dept Appl Phys, New Haven, CT 06520 USA. [DeLacy, Brendan G.] US Army Edgewood Chem Biol Ctr, Res & Technol Directorate, Aberdeen Proving Ground, MD 21010 USA. [Joannopoulos, John D.; Soljacic, Marin] MIT, Dept Phys, Cambridge, MA 02139 USA. RP Miller, OD (reprint author), MIT, Dept Math, Cambridge, MA 02139 USA. EM odmiller@math.mit.edu RI Hsu, Chia Wei/G-5486-2011 OI Hsu, Chia Wei/0000-0002-9609-7155 FU Army Research Office through the Institute for Soldier Nanotechnologies [W911NF-07-D0004]; AFOSR Multidisciplinary Research Program of the University Research Initiative (MURI) for Complex and Robust On-chip Nanophotonics [FA9550-09-1-0704] FX We thank Eli Yablonovitch, Adi Pick, Yehuda Avniel, Aristeidis Karalis, Hrvoje Buljan, Alejandro Rodriguez, and Emma Anquillare for helpful discussions. This work was supported by the Army Research Office through the Institute for Soldier Nanotechnologies under Contract No. W911NF-07-D0004, and by the AFOSR Multidisciplinary Research Program of the University Research Initiative (MURI) for Complex and Robust On-chip Nanophotonics under Grant No. FA9550-09-1-0704. NR 179 TC 6 Z9 6 U1 2 U2 16 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD FEB 22 PY 2016 VL 24 IS 4 BP 3329 EP 3364 DI 10.1364/OE.24.003329 PG 36 WC Optics SC Optics GA DF5ZQ UT WOS:000371433700017 PM 26906994 ER PT J AU Valentin-Torres, A Savarin, C Hinton, DR Phares, TW Bergmann, CC Stohlman, SA AF Valentin-Torres, Alice Savarin, Carine Hinton, David R. Phares, Timothy W. Bergmann, Cornelia C. Stohlman, Stephen A. TI Sustained TNF production by central nervous system infiltrating macrophages promotes progressive autoimmune encephalomyelitis SO JOURNAL OF NEUROINFLAMMATION LA English DT Article DE Progressive multiple sclerosis; Experimental autoimmune encephalomyelitis; Astrocytes; Interferon gamma; Tumor necrosis factor ID TUMOR-NECROSIS-FACTOR; BLOOD-BRAIN-BARRIER; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; REGULATORY T-CELLS; MHC CLASS-II; DORSAL-ROOT GANGLIA; FACTOR-ALPHA; MULTIPLE-SCLEROSIS; TRANSGENIC MICE; SPINAL-CORD AB Background: Tumor necrosis factor (TNF) has pleiotropic functions during both the demyelinating autoimmune disease multiple sclerosis (MS) and its murine model experimental autoimmune encephalomyelitis (EAE). How TNF regulates disability during progressive disease remains unresolved. Using a progressive EAE model characterized by sustained TNF and increasing morbidity, this study evaluates the role of unregulated TNF in exacerbating central nervous system (CNS) pathology and inflammation. Methods: Progressive MS was mimicked by myelin oligodendrocyte glycoprotein (MOG) peptide immunization of mice expressing a dominant negative IFN-gamma receptor alpha chain under the human glial fibrillary acidic protein promoter (GFAP gamma R1 Delta). Diseased GFAP gamma R1 Delta mice were treated with anti-TNF or control monoclonal antibody during acute disease to monitor therapeutic effects on sustained disability, demyelination, CNS inflammation, and blood brain barrier (BBB) permeability. Results: TNF was specifically sustained in infiltrating macrophages. Anti-TNF treatment decreased established clinical disability and mortality rate within 7 days. Control of disease progression was associated with a decline in myelin loss and leukocyte infiltration, as well as macrophage activation. In addition to mitigating CNS inflammation, TNF neutralization restored BBB integrity and enhanced CNS anti-inflammatory responses. Conclusions: Sustained TNF production by infiltrating macrophages associated with progressive EAE exacerbates disease severity by promoting inflammation and disruption of BBB integrity, thereby counteracting establishment of an anti-inflammatory environment required for disease remission. C1 [Valentin-Torres, Alice; Savarin, Carine; Bergmann, Cornelia C.; Stohlman, Stephen A.] Cleveland Clin, Lerner Res Inst, Dept Neurosci NC 30, 9500 Euclid Ave, Cleveland, OH 44195 USA. [Hinton, David R.] Univ So Calif, Keck Sch Med, Dept Pathol, Los Angeles, CA 90033 USA. [Phares, Timothy W.] Walter Reed Army Inst Res, Malaria Vaccine Branch, Silver Spring, MD 20910 USA. RP Bergmann, CC (reprint author), Cleveland Clin, Lerner Res Inst, Dept Neurosci NC 30, 9500 Euclid Ave, Cleveland, OH 44195 USA. EM bergmac@ccf.org FU National Multiple Sclerosis Society [RG4007B5]; Cancer Center Support grant [P30CA014089]; NIH FX The authors would like to thank Natasha Towne, Kate Stenson, Wen Wei, and Ernesto Barron for their exceptional technical assistance. This work was supported by the National Multiple Sclerosis Society research grant RG4007B5 and Cancer Center Support grant P30CA014089. Research reported here was supported by a 2015 NIH shared instrument award to the LRI Imaging Core for the Leica TCS-SP5II. NR 76 TC 4 Z9 4 U1 1 U2 4 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-2094 J9 J NEUROINFLAMM JI J. Neuroinflamm. PD FEB 22 PY 2016 VL 13 AR 46 DI 10.1186/s12974-016-0513-y PG 14 WC Immunology; Neurosciences SC Immunology; Neurosciences & Neurology GA DE6WS UT WOS:000370775900002 PM 26906225 ER PT J AU Bricker, SB Getchis, TL Chadwick, CB Rose, C Rose, JM AF Bricker, Suzanne B. Getchis, Tessa L. Chadwick, Cary B. Rose, Corim. Rose, Julie M. TI Integration of ecosystem-based models into an existing interactive web-based tool for improved aquaculture decision-making SO AQUACULTURE LA English DT Article DE Shellfish; Aquaculture; GIS; Decision support tool ID DATA-POOR ENVIRONMENTS; SHELLFISH AQUACULTURE; CARRYING-CAPACITY; SITE SELECTION; MANAGEMENT; CULTURE; ESTUARY; GIS; INDICATORS; SOUND AB Proper site selection is critical to the development and expansion of marine aquaculture. Major considerations for site selection include: potential for competing uses, environmental interactions, and animal productivity. Two types of existing site selection tools, mapping and modeling, have proven useful independently, and in some recent studies have proven useful when used together. GIS-based mapping tools have become important in the decision-making process. These tools provide access to marine and coastal datasets allowing farmers and extension agents to gather information on availability of cultivation sites. They are also used by resource managers to assess potential use conflicts (e.g. existence of commercial fishing, mooring areas, fixed fishing gear) and possible environmental interactions (e.g. presence of seagrasses, contaminants, threatened or endangered species). Models have been used separately to predict animal growth, farm productivity, and farm-related effects on the surrounding water and sediment quality. The integration of the Farm Aquaculture Resource Management (FARM) model (http://www.farmscale.org) into the U.S. state of Connecticut's Aquaculture Mapping Atlas (http://seagrant.uconn.edu/whatwedo/aquaculture/shellmap.php) was tested in three geographically distinct waterbodies within Connecticut (CT) waters of Long Island Sound. Nearshore waters within the towns of Mystic, Milford, and Westport were selected as pilot locations to determine usability and capability of the combined tools. Data from two long-term offshore sampling stations adjacent to existing shellfish leases were used to test spatial and temporal sampling variability impacts on model results. Partnerships with local monitoring programs and growers were important for acquisition of water quality data, oyster measurement data, and information about local culture practices. All sites were deemed suitable for oyster aquaculture based on model results that predicted Moderate to High growth based on estimated time to reach harvest size from one in (2.54 cm) seed oysters (Crassostrea virginica). Time to harvest varied from 282 days (High growth) to 645 days (Moderate growth) among the 22 stations in the three nearshore sites, and 724-956 days (Moderate growth) at the two offshore sites. Results from the two long-term offshore stations indicate that data from the same year must be used when comparing production-based suitability of sites. Addition of potential production estimates improved the ability to select between suitable mapping-based sites. This mapping and modeling combination should be encouraged to provide a strong basis for successful siting and expansion of aquaculture while minimizing user conflict and adverse environmental interactions. This approach may be particularly useful in waterbodies where shellfish aquaculture is possible but is not well established. Published by Elsevier B.V. C1 [Bricker, Suzanne B.] NOAA, Natl Ctr Coastal Sci, Silver Spring, MD 20910 USA. [Getchis, Tessa L.] Univ Connecticut, UConn Extens, Connecticut Sea Grant, Groton, CT USA. [Chadwick, Cary B.] Univ Connecticut, Ctr Land Use Educ & Res, Haddam, CT USA. [Rose, Corim.] US Army, Corps Engnineers, Concord, MA USA. [Rose, Julie M.] NOAA, Fisheries Northeast Fisheries Sci Ctr Milford Lab, Milford, CT USA. RP Bricker, SB (reprint author), NOAA, Natl Ctr Coastal Sci, 1305 East West Highway,Floor 9, Silver Spring, MD 20910 USA. EM suzanne.bricker@noaa.gov FU NOAA Aquaculture Program Call for Internal Proposals [NS-COAST-001-Bricker] FX The authors gratefully acknowledge the NOAA Aquaculture Program 2012 Call for Internal Proposals for funding this research under Project NS-COAST-001-Bricker. We wish to thank: Sally Cogan and Claire Gavin of Clean Up Sound and Harbors (CUSH) for the samples from Mystic River stations, Dick Harris, Nikki Cantatore, and Josh Cooper with HarborWatch for the Westport/Mill Pond samples, Bob Alix and Werner Schreiner for the help in collecting the Milford samples, Karen Rivara, Aeros Cultured Oyster Co., for measuring and weighing seed oysters, S. Plant, CT Cultured Oysters, for providing oysters for additional measurement/weight determinations, and Kristen DeRosia Banick, Connecticut Bureau of Aquaculture, for the information about typical oyster aquaculture practices. We also thank Ramon Filgueira and three anonymous reviewers for their thorough reviews, comments, and suggestions which have vastly improved our manuscript. NR 42 TC 1 Z9 1 U1 12 U2 61 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0044-8486 EI 1873-5622 J9 AQUACULTURE JI Aquaculture PD FEB 20 PY 2016 VL 453 BP 135 EP 146 DI 10.1016/j.aquaculture.2015.11.036 PG 12 WC Fisheries; Marine & Freshwater Biology SC Fisheries; Marine & Freshwater Biology GA CZ0OC UT WOS:000366803800018 ER PT J AU Cheuvront, SN Kenefick, RW AF Cheuvront, Samuel N. Kenefick, Robert W. TI Am I Drinking Enough? Yes, No, and Maybe SO JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION LA English DT Review DE dehydration; hypohydration; hydration assessment; hydration status; plasma osmolality; urine osmolality ID WATER-INTAKE; HYDRATION STATUS; PLASMA VASOPRESSIN; ESSENTIAL NUTRIENT; BLOOD OSMOLALITY; URINE VOLUME; FLUID INTAKE; THIRST; OSMOREGULATION; DEHYDRATION AB Adequate fluid intake can be dually defined as a volume of fluid (from water, beverages, and food) sufficient to replace water losses and provide for solute excretion. A wide range of fluid intakes are compatible with euhydration, whereby total body water varies narrowly from day to day by 600 to 900mL (<1% body mass). One measure of fluid intake adequacy involves enough fluid to prevent meaningful body water deficits outside this euhydration range (i.e., dehydration). Another measure of fluid intake adequacy involves enough fluid to balance the renal solute load, which can vary widely inside the euhydration range. The subtle but important distinction between the 2 types of adequacy may explain some of the ambiguity surrounding the efficacy of hydration status markers. Both perspectives of fluid intake adequacy are discussed in detail and a simple tool is reviewed that may help healthy, active, low-risk populations answer the question, Am I drinking enough?Key Teaching Points center dot Adequate fluid intake can be dually defined as a volume of fluid (from water, beverages, and food) sufficient to replace water losses and provide for solute excretion.center dot Fluid needs can differ greatly among individuals due to variation in the factors that influence both water loss and solute balance; thus, adequacy is consistent with a wide range of fluid intakes and is better gauged using hydration assessment methods.center dot Adequacy of fluid intake for replacing meaningful water losses (dehydration) can be assessed simply, inexpensively, and with reasonable fidelity among healthy, active, low-risk individuals.center dot Adequacy of fluid intake for solute excretion per se can also be assessed among individuals but is more difficult to define and less practical to measure. C1 [Cheuvront, Samuel N.; Kenefick, Robert W.] US Army Res Inst Environm Med, 15 Kansas St,Bldg 42, Natick, MA 01760 USA. RP Cheuvront, SN (reprint author), US Army Res Inst Environm Med, 15 Kansas St,Bldg 42, Natick, MA 01760 USA. EM samuel.n.cheuvront.civ@mail.mil NR 75 TC 2 Z9 2 U1 6 U2 9 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0731-5724 EI 1541-1087 J9 J AM COLL NUTR JI J. Am. Coll. Nutr. PD FEB 17 PY 2016 VL 35 IS 2 BP 185 EP 192 DI 10.1080/07315724.2015.1067872 PG 8 WC Nutrition & Dietetics SC Nutrition & Dietetics GA DG5AU UT WOS:000372085400012 PM 26885571 ER PT J AU von Pressentin, K Hoedebecke, K Pinho-Costa, L AF von Pressentin, Klaus Hoedebecke, Kyle Pinho-Costa, Luis TI South Africa has joined a global initiative for Family Medicine advocacy SO SOUTH AFRICAN FAMILY PRACTICE LA English DT Letter AB The international #1WordforFamilyMedicine initiative serves to explore the identity of family physicians and allows the international Family Medicine community to collaborate on advocating the discipline. South African family physicians provided 42 responses via a social media and online survey. Two word cloud images were created based on two iconsrecognised as being truly South African around the world - that of the national flag and former president Nelson Mandela. The #1WorldforFamilyMedicine initiative was promoted by the World Organization of Family Doctors across the globe to help celebrate World Family Doctor Day on 19 May 2015. To date, over 70 images have been created in 50 different countries on six continents. The images represent family physicians' love for their profession and the community they serve. It is hoped that this initiative will help to inspire current and future Family Medicine and primary care providers. C1 [von Pressentin, Klaus] Univ Stellenbosch, Div Family Med & Primary Care, Cape Town, South Africa. [Hoedebecke, Kyle] World Org Family Doctors WONCA Polaris, North Carolina & Robinson Hlth Clin, Dept Family Med, Ft Bragg, NC USA. [Pinho-Costa, Luis] Fanzeres Family Hlth Unit, Gondomar, Portugal. RP von Pressentin, K (reprint author), Univ Stellenbosch, Div Family Med & Primary Care, Cape Town, South Africa. EM kvonpressentin@sun.ac.za OI de Pinho-Costa, Luis/0000-0001-9241-4144 NR 4 TC 0 Z9 0 U1 0 U2 0 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 2078-6190 EI 2078-6204 J9 S AFR FAM PRACT PD FEB 17 PY 2016 VL 58 IS 1 BP 28 EP 29 DI 10.1080/20786190.2015.1085224 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA DG4DL UT WOS:000372021000007 ER PT J AU Lin, CT Chuang, CH Kerick, S Mullen, T Jung, TP Ko, LW Chen, SA King, JT McDowell, K AF Lin, Chin-Teng Chuang, Chun-Hsiang Kerick, Scott Mullen, Tim Jung, Tzyy-Ping Ko, Li-Wei Chen, Shi-An King, Jung-Tai McDowell, Kaleb TI Mind-Wandering Tends to Occur under Low Perceptual Demands during Driving SO SCIENTIFIC REPORTS LA English DT Article ID INDEPENDENT COMPONENT ANALYSIS; THETA OSCILLATIONS REFLECT; DEFAULT NETWORK; FUNCTIONAL CONNECTIVITY; EEG DYNAMICS; HUMAN BRAIN; TASK; PERFORMANCE; CORTEX; ENVIRONMENT AB Fluctuations in attention behind the wheel poses a significant risk for driver safety. During transient periods of inattention, drivers may shift their attention towards internally-directed thoughts or feelings at the expense of staying focused on the road. This study examined whether increasing task difficulty by manipulating involved sensory modalities as the driver detected the lane-departure in a simulated driving task would promote a shift of brain activity between different modes of processing, reflected by brain network dynamics on electroencephalographic sources. Results showed that depriving the driver of salient sensory information imposes a relatively more perceptually-demanding task, leading to a stronger activation in the task-positive network. When the vehicle motion feedback is available, the drivers may rely on vehicle motion to perceive the perturbations, which frees attentional capacity and tends to activate the default mode network. Such brain network dynamics could have major implications for understanding fluctuations in driver attention and designing advance driver assistance systems. C1 [Lin, Chin-Teng; Chuang, Chun-Hsiang; Ko, Li-Wei; Chen, Shi-An; King, Jung-Tai] Natl Chiao Tung Univ, Brain Res Ctr, MIRC 416,1001 Univ Rd, Hsinchu 30010, Taiwan. [Lin, Chin-Teng; Chuang, Chun-Hsiang] Univ Technol Sydney, 15 Broadway, Ultimo, NSW 2007, Australia. [Kerick, Scott; McDowell, Kaleb] US Army Res Lab, Translat Neurosci Branch, 459 Mulberry Point Rd, Aberdeen Proving Ground, MD 21005 USA. [Mullen, Tim; Jung, Tzyy-Ping] Univ Calif San Diego, Swartz Ctr Computat Neurosci, 9500 Gilman Dr, La Jolla, CA 92093 USA. [Ko, Li-Wei] Natl Chiao Tung Univ, Dept Biol Sci & Technol, Hsinchu 30010, Taiwan. RP Lin, CT; Chuang, CH (reprint author), Natl Chiao Tung Univ, Brain Res Ctr, MIRC 416,1001 Univ Rd, Hsinchu 30010, Taiwan.; Lin, CT; Chuang, CH (reprint author), Univ Technol Sydney, 15 Broadway, Ultimo, NSW 2007, Australia. EM ctlin@mail.nctu.edu.tw; cch.chuang@gmail.com OI Chuang, Chun-Hsiang/0000-0002-5043-8380 FU UST-UCSD International Center of Excellence in Advanced Bioengineering - Taiwan Ministry of Science and Technology I-RiCE Program [MOST 103-2911-I-009-101]; Aiming for the Top University Plan of National Chiao Tung University; Ministry of Education, Taiwan [104W963]; Army Research Laboratory [W911NF-10-2-0022] FX This work was supported in part by the UST-UCSD International Center of Excellence in Advanced Bioengineering sponsored by the Taiwan Ministry of Science and Technology I-RiCE Program under Grant Number MOST 103-2911-I-009-101, in part by the Aiming for the Top University Plan of National Chiao Tung University, the Ministry of Education, Taiwan, under Contract 104W963. Research was also sponsored in part by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-10-2-0022. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation heron. NR 61 TC 0 Z9 0 U1 3 U2 11 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD FEB 17 PY 2016 VL 6 AR 21353 DI 10.1038/srep21353 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DE0MD UT WOS:000370318100001 PM 26882993 ER PT J AU Lyon, R Berry-Caban, CS Lyon, C Markowski, H Boltinhouse, SL AF Lyon, Regan Berry-Caban, Cristobal S. Lyon, Christopher Markowski, Helen Boltinhouse, Sara L. TI Factors affecting conviction rates of intoxicated driver patients in two large trauma centers SO TRAFFIC INJURY PREVENTION LA English DT Article DE alcoholism; emergency department; trauma; DUI ID INJURY SEVERITY SCORE; UNITED-STATES; ALCOHOL; CARE; ENFORCEMENT; CRASHES; LIMITS; LAWS; BAC AB Objective: Outcomes from previous studies report the driving under the influence (DUI) conviction rates for trauma patients in several cities within Canada and the United States over the last 2 decades. This study reports charge, conviction, and prosecution rates for trauma patients at 2 level I trauma centers servicing a large metropolitan city. Methods: A retrospective review of the trauma databases was completed to identify patients meeting inclusion criteria. Four hundred sixty patients were identified and their records were compared with the district attorney's records for DUI charges and convictions. Results: The conviction rate for this study was 8.7%, demonstrating continued low rates of conviction despite growing interest and public awareness of drinking and driving. Conclusions: We discuss legal considerations that providers should consider when treating patients who have been drinking and driving. C1 [Lyon, Regan] Emergency Dept, 51st Med Operat Squadron, Osan Ab, South Korea. [Berry-Caban, Cristobal S.; Boltinhouse, Sara L.] Womack Army Med Ctr, Dept Clin Invest, Ft Bragg, NC USA. [Lyon, Christopher] Wood Smith Henning & Berman LLP Law Firm, New York, NY USA. [Markowski, Helen] Univ Texas Hlth Sci Ctr San Antonio, San Antonio Univ Hosp, Trauma Surg, San Antonio, TX 78229 USA. RP Berry-Caban, CS (reprint author), Womack Army Med Ctr, Dept Clin Invest, Ft Bragg, NC USA.; Berry-Caban, CS (reprint author), Womack Army Med Ctr, DME RES, Dept Clin Invest, Ft Bragg, NC USA. EM cristobal.s.berry-caban.civ@mail.mil NR 30 TC 0 Z9 0 U1 0 U2 3 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1538-9588 EI 1538-957X J9 TRAFFIC INJ PREV JI Traffic Inj. Prev. PD FEB 17 PY 2016 VL 17 IS 2 BP 109 EP 113 DI 10.1080/15389588.2015.1045503 PG 5 WC Public, Environmental & Occupational Health; Transportation SC Public, Environmental & Occupational Health; Transportation GA DE4TP UT WOS:000370623500002 PM 26042876 ER PT J AU Racke, DA Neupane, MR Monti, OLA AF Racke, David A. Neupane, Mahesh R. Monti, Oliver L. A. TI Valence and conduction band structure of the quasi-two-dimensional semiconductor SnS2 SO PHYSICAL REVIEW B LA English DT Article ID TRANSITION-METAL DICHALCOGENIDES; SINGLE-LAYER MOS2; TIN DISULFIDE; 2-DIMENSIONAL MATERIALS; ELECTRONIC-STRUCTURE; EDGE STATES; GAP STATES; PHOTOEMISSION; INTERFACES; DYNAMICS AB We present the momentum-resolved photoemission spectroscopy of both the valence and the conduction band region in the quasi-two-dimensional van der Waals-layered indirect band gap semiconductor SnS2. Using a combination of angle-resolved ultraviolet photoemission and angle-resolved two-photon photoemission (AR-2PPE) spectroscopy, we characterize the band structure of bulk SnS2. Comparison with density functional theory calculations shows excellent quantitative agreement in the valence band region and reveals several localized bands that likely originate from defects such as sulfur vacancies. Evidence for a moderate density of defects is also observed by AR-2PPE in the conduction band region, leading to localized bands not present in the computational results. The energetic structure and dispersion of the conduction bands is captured well by the computational treatment, with some quantitative discrepancies remaining. Our results provide a broader understanding of the electronic structure of SnS2 in particular and van der Waals-layered semiconductors in general. C1 [Racke, David A.; Monti, Oliver L. A.] Univ Arizona, Dept Chem & Biochem, Tucson, AZ 85721 USA. [Neupane, Mahesh R.] US Army Res Lab, Macromol Sci & Technol Branch, Aberdeen Proving Ground, MD 21005 USA. [Monti, Oliver L. A.] Univ Arizona, Dept Phys, Tucson, AZ 85721 USA. RP Monti, OLA (reprint author), Univ Arizona, Dept Chem & Biochem, Tucson, AZ 85721 USA.; Neupane, MR (reprint author), US Army Res Lab, Macromol Sci & Technol Branch, Aberdeen Proving Ground, MD 21005 USA.; Monti, OLA (reprint author), Univ Arizona, Dept Phys, Tucson, AZ 85721 USA. EM mahesh.neupane.ctr@mail.mil; monti@u.arizona.edu FU Department of Defense (DOD) High Performance Computing Modernization Program at the US Air Force Research Laboratory; US Army Engineer Research and Development Center DOD Supercomputing Resource Centers; National Science Foundation [CHE-1213243] FX M.R.N. was supported by an appointment to the Postgraduate Research Participation Program at the US Army Research Laboratory (USARL) administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the US Department of Energy and the USARL. The computational work was supported by grants from the Department of Defense (DOD) High Performance Computing Modernization Program at the US Air Force Research Laboratory and US Army Engineer Research and Development Center DOD Supercomputing Resource Centers. D.A.R. and O.L.A.M. are grateful for financial support from the National Science Foundation under Grant No. CHE-1213243. We also acknowledge Prof. Bruce Parkinson (University of Wyoming) for generously providing us with SnS2 crystals. NR 60 TC 1 Z9 1 U1 22 U2 72 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2469-9950 EI 2469-9969 J9 PHYS REV B JI Phys. Rev. B PD FEB 17 PY 2016 VL 93 IS 8 AR 085309 DI 10.1103/PhysRevB.93.085309 PG 7 WC Physics, Condensed Matter SC Physics GA DD9LD UT WOS:000370246100003 ER PT J AU Gumbs, G Iurov, A Wu, JY Lin, MF Fekete, P AF Gumbs, Godfrey Iurov, Andrii Wu, Jhao-Ying Lin, M. F. Fekete, Paula TI Plasmon Excitations of Multi-layer Graphene on a Conducting Substrate SO SCIENTIFIC REPORTS LA English DT Article ID DIELECTRIC FUNCTION; METAL CONTACTS; SUPERLATTICE; SURFACE AB We predict the existence of low-frequency nonlocal plasmons at the vacuum-surface interface of a superlattice of N graphene layers interacting with conducting substrate. We derive a dispersion function that incorporates the polarization function of both the graphene monolayers and the semi-infinite electron liquid at whose surface the electrons scatter specularly. We find a surface plasmon-polariton that is not damped by particle-hole excitations or the bulk modes and which separates below the continuum mini-band of bulk plasmon modes. The surface plasmon frequency of the hybrid structure always lies below omega(s)=p/root 2, the surface plasmon frequency of the conducting substrate. The intensity of this mode depends on the distance of the graphene layers from the conductor's surface, the energy band gap between valence and conduction bands of graphene monolayer and, most importantly, on the number of two-dimensional layers. For a sufficiently large number of layers (N greater than or similar to 7) the hybrid structure has no surface plasmon. The existence of plasmons with different dispersion relations indicates that quasiparticles with different group velocity may coexist for various ranges of wavelengths determined by the number of layers in the superlattice. C1 [Gumbs, Godfrey] CUNY, Hunter Coll, Dept Phys & Astron, 695 Pk Ave, New York, NY 10065 USA. [Iurov, Andrii] Univ New Mexico, Ctr High Technol Mat, Albuquerque, NM 87106 USA. [Wu, Jhao-Ying; Lin, M. F.] Natl Cheng Kung Univ, Dept Phys, Tainan 701, Taiwan. [Fekete, Paula] US Mil Acad, West Point, NY 10996 USA. [Gumbs, Godfrey] Donostia Int Phys Ctr, P Manuel de Lardizabal 4, San Sebastian 20018, Spain. RP Gumbs, G (reprint author), CUNY, Hunter Coll, Dept Phys & Astron, 695 Pk Ave, New York, NY 10065 USA.; Gumbs, G (reprint author), Donostia Int Phys Ctr, P Manuel de Lardizabal 4, San Sebastian 20018, Spain. EM ggumbs@hunter.cuny.edu RI DONOSTIA INTERNATIONAL PHYSICS CTR., DIPC/C-3171-2014 FU AFRL [FA 9453-13-1-0291] FX This research was supported by contract #FA 9453-13-1-0291 of AFRL. We are grateful to Danhong Huang for helpful discussions. NR 48 TC 3 Z9 3 U1 13 U2 41 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD FEB 17 PY 2016 VL 6 AR 21063 DI 10.1038/srep21063 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DD9EW UT WOS:000370229500002 PM 26883086 ER PT J AU Wang, CX Granskog, MA Hudson, SR Gerland, S Pavlov, AK Perovich, DK Nicolaus, M AF Wang, Caixin Granskog, Mats A. Hudson, Stephen R. Gerland, Sebastian Pavlov, Alexey K. Perovich, Donald K. Nicolaus, Marcel TI Atmospheric conditions in the central Arctic Ocean through the melt seasons of 2012 and 2013: Impact on surface conditions and solar energy deposition into the ice-ocean system SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES LA English DT Article DE central Arctic Ocean; surface condition; solar energy; atmospheric condition; melt season ID SEA-ICE; ALBEDO; BUDGET; ONSET; EVOLUTION; RADIATION; THICKNESS; SNOWMELT; CYCLONE; COVER AB Spectral Radiation Buoys and ice mass balance buoys were deployed on first-year ice near the North Pole in April 2012 and 2013, collecting in-band (350-800nm) solar radiation and ice and snow mass balance data over the complete summer melt seasons. With complementary European ERA-Interim reanalysis, National Centers for Environmental Prediction (NCEP) Climate forecast system version 2 (CFSv2) analysis and satellite passive microwave data, we examine the evolution of atmospheric and surface melt conditions in the two differing melt seasons. Prevailing atmospheric conditions contributed to a longer and more continuous melt season in summer 2012 than in 2013, which was corroborated by in situ observations. ERA-Interim reanalysis data showed that longwave radiation likely played a key role in delaying the snowmelt onset in 2013. The earlier melt onset in 2012 reduced the albedo, providing a positive ice-albedo feedback at a time when solar insolation was high. Due to earlier melt onset and later freeze-up in 2012, more solar heat was deposited into the ice-ocean system than in 2013. Summer 2013 was characterized by later melt onset, intermittent freezing events and an earlier fall freeze-up, resulting in considerably fewer effective days of surface melt and a higher average albedo. Calculations for idealized seasonal albedo evolution show that moving the melt onset just 1week earlier in mid-June increases the total absorbed solar radiation by nearly 14% for the summer season. Therefore, the earlier melt onset may have been one of the most important factors driving the more dramatic melt season in 2012 than 2013, though atmospheric circulation patterns, e.g., cyclone in early August 2012, likely contributed as well. C1 [Wang, Caixin; Granskog, Mats A.; Hudson, Stephen R.; Gerland, Sebastian; Pavlov, Alexey K.] Norwegian Polar Res Inst, Fram Ctr, Tromso, Norway. [Perovich, Donald K.] US Army, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. [Nicolaus, Marcel] Helmholtz Zentrum Polar & Meeresforsch, Alfred Wegener Inst, Bremerhaven, Germany. RP Wang, CX (reprint author), Norwegian Polar Res Inst, Fram Ctr, Tromso, Norway. EM caixin.wang@npolar.no FU Research Council of Norway [193592, 221961/F20]; Fram Centre "Arctic Ocean" flagship program through the SOLICE project; Centre for Ice, Climate and Ecosystems (ICE) at NPI; European Commission [265863] FX The authors are grateful to Marius Bratrein, Jago Wallenschus, Tor Ivan Karlsen, and Kristen Fossan at Norwegian Polar Institute (NPI) for their work with SRB design, construction, and deployments. We also wish to acknowledge National Snow and Ice Data Center for providing SSMIS data, ECWMF for ERA-Interim data, NCEP for CFSv2 data, and North Pole Environmental Observatory (NPEO), University of Washington, USA, for webcam photos. This study was supported by the Research Council of Norway through projects AMORA (project 193592) and STASIS (project 221961/F20), by the Fram Centre "Arctic Ocean" flagship program through the SOLICE project, by Centre for Ice, Climate and Ecosystems (ICE) at NPI, and by ACCESS, a European project within the Ocean of Tomorrow call of the European Commission Seventh Framework Programme (grant 265863). Solar radiation data are available on request to data@npolar.no, and snow and ice mass balance data can be found at http://imb.erdc.dren.mil/buoysum.htm. Constructive comments from two anonymous reviewers aided to improve the paper. NR 67 TC 1 Z9 1 U1 3 U2 4 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-897X EI 2169-8996 J9 J GEOPHYS RES-ATMOS JI J. Geophys. Res.-Atmos. PD FEB 16 PY 2016 VL 121 IS 3 BP 1043 EP 1058 DI 10.1002/2015JD023712 PG 16 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA DF6QW UT WOS:000371481700002 ER PT J AU Svenkeson, A Glaz, B Stanton, S West, BJ AF Svenkeson, Adam Glaz, Bryan Stanton, Samuel West, Bruce J. TI Spectral decomposition of nonlinear systems with memory SO PHYSICAL REVIEW E LA English DT Article ID FRACTIONAL CALCULUS; ANOMALOUS DIFFUSION; INSTANTANEOUS VELOCITY; INTEGRAL-OPERATORS; EQUATION APPROACH; STRANGE KINETICS; BROWNIAN-MOTION; KOOPMAN MODES; RANDOM-WALKS; FLOWS AB We present an alternative approach to the analysis of nonlinear systems with long-term memory that is based on the Koopman operator and a Levy transformation in time. Memory effects are considered to be the result of interactions between a system and its surrounding environment. The analysis leads to the decomposition of a nonlinear system with memory into modes whose temporal behavior is anomalous and lacks a characteristic scale. On average, the time evolution of a mode follows a Mittag-Leffler function, and the system can be described using the fractional calculus. The general theory is demonstrated on the fractional linear harmonic oscillator and the fractional nonlinear logistic equation. When analyzing data from an ill-defined (black-box) system, the spectral decomposition in terms of Mittag-Leffler functions that we propose may uncover inherent memory effects through identification of a small set of dynamically relevant structures that would otherwise be obscured by conventional spectral methods. Consequently, the theoretical concepts we present may be useful for developing more general methods for numerical modeling that are able to determine whether observables of a dynamical system are better represented by memoryless operators, or operators with long-term memory in time, when model details are unknown. C1 [Svenkeson, Adam; Glaz, Bryan] Army Res Lab, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA. [Stanton, Samuel] Army Res Off, Engn Sci Directorate, Res Triangle Pk, NC 27709 USA. [West, Bruce J.] Army Res Off, Informat Sci Directorate, Res Triangle Pk, NC 27709 USA. RP Svenkeson, A (reprint author), Army Res Lab, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA. NR 75 TC 0 Z9 0 U1 8 U2 11 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2470-0045 EI 2470-0053 J9 PHYS REV E JI Phys. Rev. E PD FEB 16 PY 2016 VL 93 IS 2 AR 022211 DI 10.1103/PhysRevE.93.022211 PG 10 WC Physics, Fluids & Plasmas; Physics, Mathematical SC Physics GA DD9LY UT WOS:000370248300010 PM 26986335 ER PT J AU Obaldia, N Dow, GS Gerena, L Kyle, D Otero, W Mantel, PY Baro, N Daniels, R Mukherjee, A Childs, LM Buckee, C Duraisingh, MT Volkman, SK Wirth, DF Marti, M AF Obaldia, Nicanor, III Dow, Geoffrey S. Gerena, Lucia Kyle, Dennis Otero, William Mantel, Pierre-Yves Baro, Nicholas Daniels, Rachel Mukherjee, Angana Childs, Lauren M. Buckee, Caroline Duraisingh, Manoj T. Volkman, Sarah K. Wirth, Dyann F. Marti, Matthias TI Altered drug susceptibility during host adaptation of a Plasmodium falciparum strain in a non-human primate model SO SCIENTIFIC REPORTS LA English DT Article ID AOTUS-LEMURINUS-LEMURINUS; IN-VITRO; ARTEMISININ RESISTANCE; COMBINATION THERAPY; ANTIMALARIAL-DRUGS; MALARIA; MEFLOQUINE; ARTESUNATE; MONKEYS; GENE AB Infections with Plasmodium falciparum, the most pathogenic of the Plasmodium species affecting man, have been reduced in part due to artemisinin-based combination therapies. However, artemisinin resistant parasites have recently emerged in South-East Asia. Novel intervention strategies are therefore urgently needed to maintain the current momentum for control and elimination of this disease. In the present study we characterize the phenotypic and genetic properties of the multi drug resistant (MDR) P. falciparum Thai C2A parasite strain in the non-human Aotus primate model, and across multiple passages. Aotus infections with C2A failed to clear upon oral artesunate and mefloquine treatment alone or in combination, and ex vivo drug assays demonstrated reduction in drug susceptibility profiles in later Aotus passages. Further analysis revealed mutations in the pfcrt and pfdhfr loci and increased parasite multiplication rate (PMR) across passages, despite elevated pfmdr1 copy number. Altogether our experiments suggest alterations in parasite population structure and increased fitness during Aotus adaptation. We also present data of early treatment failures with an oral artemisinin combination therapy in a pre-artemisinin resistant P. falciparum Thai isolate in this animal model. C1 [Obaldia, Nicanor, III; Mantel, Pierre-Yves; Baro, Nicholas; Daniels, Rachel; Mukherjee, Angana; Duraisingh, Manoj T.; Volkman, Sarah K.; Wirth, Dyann F.; Marti, Matthias] Harvard Univ, Dept Immunol & Infect Dis, TH Chan Sch Publ Hlth, Boston, MA 02115 USA. [Dow, Geoffrey S.; Gerena, Lucia] Walter Reed Army Inst Res, Silver Spring, MD USA. [Kyle, Dennis] Univ S Florida, Dept Global Hlth, Tampa, FL USA. [Obaldia, Nicanor, III; Otero, William] Trop Med Res Inst Conmemorativo Gorgas Estudios S, Ctr Evaluat Antimalarial Drugs & Vaccines, Panama City, Panama. [Childs, Lauren M.; Buckee, Caroline] Ctr Communicable Dis Dynam, Boston, MA USA. [Childs, Lauren M.; Buckee, Caroline] Harvard Univ, TH Chan Sch Publ Hlth, Boston, MA 02115 USA. [Childs, Lauren M.; Buckee, Caroline] Harvard Univ, Dept Epidemiol, TH Chan Sch Publ Hlth, Boston, MA 02115 USA. [Volkman, Sarah K.; Wirth, Dyann F.] Broad Inst MIT & Harvard, Cambridge, MA USA. [Volkman, Sarah K.] Simmons Coll, Sch Nursing & Hlth Sci, Boston, MA 02115 USA. RP Obaldia, N; Marti, M (reprint author), Harvard Univ, Dept Immunol & Infect Dis, TH Chan Sch Publ Hlth, Boston, MA 02115 USA.; Obaldia, N (reprint author), Trop Med Res Inst Conmemorativo Gorgas Estudios S, Ctr Evaluat Antimalarial Drugs & Vaccines, Panama City, Panama. EM nobaldia@hsph.harvard.edu; mmarti@hsph.harvard.edu OI Childs, Lauren/0000-0003-3904-3895 FU USAMDA contract [W81XWH-07-C-044]; SENACYT-IFHARU Panama doctoral fellowship; Sistema Nacional de Investigacion of Panama (SNI); Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA; National Institute of General Medical Sciences [U54GM088558] FX The authors wish to thank the Directors of the Gorgas Memorial Institute in Panama City, Drs. Jorge Motta and Nestor Sosa; Gines Sanchez and Gladys Calvino at Tropical Medicine Research in Panama City for administrative support; Maritza Brewer for secretarial assistance; Camilo Marin, Temistocles Gonzales and the animal care takers for their assistance with animal handling and care. We thank Katelyn Durfee for help with the molecular barcoding and drug resistance marker typing and Courtney Edison for help with the kelch13 propeller domain sequencing. This work was supported in part by a USAMDA contract W81XWH-07-C-044, a SENACYT-IFHARU Panama doctoral fellowship to Nicanor Obaldia III, the Sistema Nacional de Investigacion of Panama (SNI) and the Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA. LC and COB were supported by award number U54GM088558 from the National Institute of General Medical Sciences. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of General Medical Sciences or the National Institutes of Health. NR 52 TC 1 Z9 1 U1 0 U2 1 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD FEB 16 PY 2016 VL 6 AR 21216 DI 10.1038/srep21216 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DD9DJ UT WOS:000370225600001 PM 26880111 ER PT J AU Salje, H Cauchemez, S Alera, MT Rodriguez-Barraguer, I Thaisomboonsuk, B Srikiatkhachorn, A Lago, CB Villa, D Klungthong, C Tac-An, IA Fernandez, S Velasco, JM Roque, VG Nisalak, A Macareo, LR Levy, JW Cummings, D Yoon, IK AF Salje, Henrik Cauchemez, Simon Alera, Maria Theresa Rodriguez-Barraguer, Isabel Thaisomboonsuk, Butsaya Srikiatkhachorn, Anon Lago, Catherine B. Villa, Daisy Klungthong, Chonticha Tac-An, Ilya A. Fernandez, Stefan Velasco, John Mark Roque, Vito G., Jr. Nisalak, Ananda Macareo, Louis R. Levy, Jens W. Cummings, Derek Yoon, In-Kyu TI Reconstruction of 60 Years of Chikungunya Epidemiology in the Philippines Demonstrates Episodic and Focal Transmission SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE chikungunya; epidemiology; Philippines; modeling; serological study ID VIRUS; DENGUE; PREVALENCE; ANTIBODIES; INFECTION; DYNAMICS; DISEASE; SPREAD; MODEL AB Proper understanding of the long-term epidemiology of chikungunya has been hampered by poor surveillance. Outbreak years are unpredictable and cases often misdiagnosed. Here we analyzed age-specific data from 2 serological studies (from 1973 and 2012) in Cebu, Philippines, to reconstruct both the annual probability of infection and population-level immunity over a 60-year period (1952-2012). We also explored whether seroconversions during 2012-2013 were spatially clustered. Our models identified 4 discrete outbreaks separated by an average delay of 17 years. On average, 23% (95% confidence interval [CI], 16%-37%) of the susceptible population was infected per outbreak, with >50% of the entire population remaining susceptible at any point. Participants who seroconverted during 2012-2013 were clustered at distances of <230 m, suggesting focal transmission. Large-scale outbreaks of chikungunya did not result in sustained multiyear transmission. Nevertheless, we estimate that >350 000 infections were missed by surveillance systems. Serological studies could supplement surveillance to provide important insights on pathogen circulation. C1 [Salje, Henrik; Rodriguez-Barraguer, Isabel; Cummings, Derek] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA. [Srikiatkhachorn, Anon] Univ Massachusetts, Sch Med, Dept Med, Div Infect Dis & Immunol, Worcester, MA USA. [Cummings, Derek] Univ Florida, Dept Biol, Gainesville, FL USA. [Salje, Henrik; Cauchemez, Simon] Inst Pasteur, Math Modeling Unit, Paris, France. [Alera, Maria Theresa; Lago, Catherine B.; Velasco, John Mark] Armed Forces Res Inst Med Sci, Virol Res Unit, Cebu, Philippines. [Villa, Daisy; Tac-An, Ilya A.] Cebu City Hlth Dept, Cebu, Philippines. [Roque, Vito G., Jr.] Natl Epidemiol Ctr, Dept Hlth, Manila, Philippines. [Thaisomboonsuk, Butsaya; Klungthong, Chonticha; Fernandez, Stefan; Nisalak, Ananda; Macareo, Louis R.; Levy, Jens W.; Yoon, In-Kyu] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Yoon, In-Kyu] Int Vaccine Inst, Seoul, South Korea. RP Salje, H (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, 615 N Wolfe St Rm E6008, Baltimore, MD 21205 USA. EM hsalje@jhu.edu OI Salje, Henrik/0000-0003-3626-4254 FU National Institutes of Health [R01 AI102939-01A1]; Armed Forces Health Surveillance Center-Global Emerging Infections Surveillance and Response System [P0149 14 AF] FX This work was supported by the National Institutes of Health (grant R01 AI102939-01A1) and the Armed Forces Health Surveillance Center-Global Emerging Infections Surveillance and Response System (grant P0149 14 AF). NR 30 TC 6 Z9 6 U1 0 U2 5 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD FEB 15 PY 2016 VL 213 IS 4 BP 604 EP 610 DI 10.1093/infdis/jiv470 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA DG9XS UT WOS:000372437700017 PM 26410592 ER PT J AU Wu, XW Darlington, DN Cap, AP AF Wu, Xiaowu Darlington, Daniel N. Cap, Andrew P. TI Procoagulant and fibrinolytic activity after polytrauma in rat SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY LA English DT Article DE thrombin; plasmin; fibrinolysis; coagulation; hemorrhage ID ACUTE TRAUMATIC COAGULOPATHY; ACTIVATED PROTEIN-C; FACTOR-VIII-C; TRANEXAMIC ACID; FACTOR-VA; PLASMIN; HYPERFIBRINOLYSIS; COAGULATION; INACTIVATION; THROMBOMODULIN AB The purpose of this study was to determine whether trauma-induced coagulopathy is due to changes in 1) thrombin activity, 2) plasmin activity, and/or 3) factors that stimulate or inhibit thrombin or plasmin. Sprague-Dawley rats were anesthetized with 1-2% isoflurane/100% oxygen, and their left femoral artery and vein were cannulated. Polytrauma included right femur fracture, and damage to the small intestines, the left and medial liver lobes, and right leg skeletal muscle. Rats were then bled 40% of blood volume. Plasma samples were taken before trauma, and at 30, 60, 120, and 240 min. Polytrauma and hemorrhage led to a significant fall in prothrombin levels. However, circulating thrombin activity did not change significantly over time. Antithrombin III and alpha 2 macroglobulin fell significantly by 2 h, then rose by 4 h. Soluble thrombomodulin was significantly elevated over the 4 h. Circulating plasmin activity, plasminogen, and D-dimers were elevated for the entire 4 h. Tissue plasminogen activator (tPA) was elevated at 30 min, then decreased below baseline levels after 1 h. Plasminogen activator inhibitor-1 was significantly elevated at 2-4 h. Neither tissue factor pathway inhibitor nor thrombin activatable fibrinolysis inhibitor changed significantly over time. The levels of prothrombin and plasminogen were 30-100 times higher than their respective active enzymes. Polytrauma and hemorrhage in rats lead to a fibrinolytic coagulopathy, as demonstrated by an elevation in plasmin activity, D-dimers, and tPA. These results are consistent with the observed clinical benefit of tranexamic acid in trauma patients. C1 US Army Inst Surg Res, Blood Res, Ft Sam Houston, TX 78234 USA. Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX 78229 USA. RP Wu, XW (reprint author), US Army Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM xiaowu.wu.civ@mail.mil FU U.S. Army Medical Research Material Command FX This study was funded by the U.S. Army Medical Research Material Command. NR 38 TC 2 Z9 2 U1 2 U2 7 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0363-6119 EI 1522-1490 J9 AM J PHYSIOL-REG I JI Am. J. Physiol.-Regul. Integr. Comp. Physiol. PD FEB 15 PY 2016 VL 310 IS 4 BP R323 EP R329 DI 10.1152/ajpregu.00401.2015 PG 7 WC Physiology SC Physiology GA DD7SZ UT WOS:000370125700002 PM 26632604 ER PT J AU Seo, M Yamaguchi, H Mohite, AD Boubanga-Tombet, S Blancon, JC Najmaei, S Ajayan, PM Lou, J Taylor, AJ Prasankumar, RP AF Seo, Minah Yamaguchi, Hisato Mohite, Aditya D. Boubanga-Tombet, Stephane Blancon, Jean-Christophe Najmaei, Sina Ajayan, Pulickel M. Lou, Jun Taylor, Antoinette J. Prasankumar, Rohit P. TI Ultrafast Optical Microscopy of Single Monolayer Molybdenum Disulfide Flakes SO SCIENTIFIC REPORTS LA English DT Article ID MONO LAYER MOS2; INTEGRATED-CIRCUITS; CARRIER DYNAMICS; NANOWIRES; RECOMBINATION; PHOTOLUMINESCENCE; SPECTROSCOPY; NANOSHEETS; EXCITONS; DEFECTS AB We have performed ultrafast optical microscopy on single flakes of atomically thin CVD-grown molybdenum disulfide, using non-degenerate femtosecond pump-probe spectroscopy to excite and probe carriers above and below the indirect and direct band gaps. These measurements reveal the influence of layer thickness on carrier dynamics when probing near the band gap. Furthermore, fluencedependent measurements indicate that carrier relaxation is primarily influenced by surface-related defect and trap states after above-bandgap photoexcitation. The ability to probe femtosecond carrier dynamics in individual flakes can thus give much insight into light-matter interactions in these twodimensional nanosystems. C1 [Seo, Minah; Boubanga-Tombet, Stephane; Taylor, Antoinette J.; Prasankumar, Rohit P.] Los Alamos Natl Lab, Ctr Integrated Nanotechnol, POB 1663, Los Alamos, NM 87545 USA. [Seo, Minah] Korea Inst Sci & Technol, Sensor Syst Res Ctr, Seoul, South Korea. [Yamaguchi, Hisato; Mohite, Aditya D.] Los Alamos Natl Lab, Mat Phys & Applicat Div, Mat Synth & Integrated Devices, POB 1663, Los Alamos, NM 87545 USA. [Blancon, Jean-Christophe] Los Alamos Natl Lab, Div Chem, Phys Chem & Appl Spect, POB 1663, Los Alamos, NM 87545 USA. [Najmaei, Sina; Ajayan, Pulickel M.; Lou, Jun] Rice Univ, Dept Mat Sci & NanoEngn, Houston, TX 77005 USA. [Boubanga-Tombet, Stephane] Tohoku Univ, Elect Commun Res Inst, Aoba Ku, 2-1-1 Katahira, Sendai, Miyagi 9808577, Japan. [Najmaei, Sina] US Army, Res Labs, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RP Prasankumar, RP (reprint author), Los Alamos Natl Lab, Ctr Integrated Nanotechnol, POB 1663, Los Alamos, NM 87545 USA. EM rpprasan@lanl.gov RI Yamaguchi, Hisato/C-5571-2008; Boubanga Tombet, Stephane/E-9985-2015 OI Blancon, Jean-Christophe/0000-0002-3833-5792; Yamaguchi, Hisato/0000-0002-6703-8826; FU Department of Energy, Office of Basic Energy Sciences, Division of Materials Science and Engineering; U.S. Department of Energy (DOE), Office of Basic Energy Sciences (BES); LANL Laboratory Directed Research and Development Program; U.S. Department of Energy [DE-AC52-06NA25396]; KIST institutional programs [2E25382] FX This work was primarily supported by the Department of Energy, Office of Basic Energy Sciences, Division of Materials Science and Engineering, and performed in part at the Center for Integrated Nanotechnologies (CINT), a U.S. Department of Energy (DOE), Office of Basic Energy Sciences (BES) user facility. Additional support was provided by the LANL Laboratory Directed Research and Development Program. Los Alamos National Laboratory, an affirmative action equal opportunity employer, is operated by Los Alamos National Security, LLC, for the National Nuclear Security administration of the U.S. Department of Energy under contract no. DE-AC52-06NA25396. This work was also partially supported by the KIST institutional programs (Project No. 2E25382). We thank Jim Werner and Doug Shepherd of LANL for their support in PL image measurements. NR 41 TC 2 Z9 2 U1 15 U2 50 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD FEB 15 PY 2016 VL 6 AR 21601 DI 10.1038/srep21601 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DD6OL UT WOS:000370043400001 PM 26876194 ER PT J AU Tabandeh-Khorshid, M Ferguson, JB Schultz, BF Kim, CS Cho, K Rohatgi, PK AF Tabandeh-Khorshid, Meysam Ferguson, J. B. Schultz, Benjamin F. Kim, Chang-Soo Cho, Kyu Rohatgi, Pradeep K. TI Strengthening mechanisms of graphene- and Al2O3-reinforced aluminum nanocomposites synthesized by room temperature milling SO MATERIALS & DESIGN LA English DT Article DE Nanostructured materials; Metal matrix composites; X-ray diffraction; Powder metallurgy; Hardness measurement ID METAL-MATRIX NANOCOMPOSITES; FIB-SEM SYSTEM; YIELD STRENGTH; AL-ALLOY; COMPOSITES; BEHAVIOR; MICROSTRUCTURE; MG; STRESS; REINFORCEMENT AB Powder metallurgy (PM) is a widely used processing method to synthesize ultrafine and nanometric grain -sized alloys and composites. While most previous work on synthesizing nanocrystalline (NC) metal-matrix nanocomposites (MMNCs) has used cryomilling technique with liquid nitrogen and stearic acid followed by high temperature/high vacuum drying, we employed an advanced room temperature method that involves milling in ethanol followed by low temperature atmospheric drying - a much less expensive process. To understand the strengthening mechanisms of MMNCs, pure NC Al was reinforced with varying concentrations of Al2O3 nanoparticles (NPs) and graphene nanoplatelets (GNPs). The results show that i) room temperature milling in ethanol followed by a relatively low temperature drying treatment can produce NC Al and NC Al MMNCs with grain sizes comparable to materials produced by cryomilling, ii) grain boundary strengthening as described by the Hall-Petch relation accounts for the strength of Al-Al2O3 MMNCs, and iii) grain boundary strengthening and solute strengthening seem to account for the strength in Al-GNP MMNCs. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Tabandeh-Khorshid, Meysam; Ferguson, J. B.; Schultz, Benjamin F.; Kim, Chang-Soo; Rohatgi, Pradeep K.] Univ Wisconsin, Mat Sci & Engn Dept, Milwaukee, WI 53211 USA. [Cho, Kyu] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Tabandeh-Khorshid, M (reprint author), Univ Wisconsin, Mat Sci & Engn Dept, Milwaukee, WI 53211 USA. EM meysam@uwm.edu FU U.S. Army Research Laboratory [W911NF-08-2-0014, W911NF-15-2-0005] FX This material is based upon work supported by the U.S. Army Research Laboratory under Cooperative Agreements nos. W911NF-08-2-0014 and W911NF-15-2-0005. The views, opinions, and conclusions made in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 43 TC 4 Z9 4 U1 16 U2 51 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-1275 EI 1873-4197 J9 MATER DESIGN JI Mater. Des. PD FEB 15 PY 2016 VL 92 BP 79 EP 87 DI 10.1016/j.matdes.2015.12.007 PG 9 WC Materials Science, Multidisciplinary SC Materials Science GA DC4LH UT WOS:000369191900010 ER PT J AU Bautista, CT Wurapa, E Sateren, WB Morris, S Hollingsworth, B Sanchez, JL AF Bautista, Christian T. Wurapa, Eyako Sateren, Warren B. Morris, Sara Hollingsworth, Bruce Sanchez, Jose L. TI Bacterial vaginosis: a synthesis of the literature on etiology, prevalence, risk factors, and relationship with chlamydia and gonorrhea infections SO MILITARY MEDICAL RESEARCH LA English DT Review DE Bacterial vaginosis; Chlamydia; Gonorrhea; Military; Epidemiology; STI ID SEXUALLY-TRANSMITTED-DISEASES; HAEMOPHILUS-VAGINALIS; GARDNERELLA-VAGINALIS; NONSPECIFIC VAGINITIS; NEISSERIA-GONORRHOEAE; PREGNANT-WOMEN; TRACHOMATIS INFECTIONS; GENITAL-INFECTION; SEX WORKERS; GRAM STAIN AB Bacterial vaginosis (BV) is a common vaginal disorder in women of reproductive age. Since the initial work of Leopoldo in 1953 and Gardner and Dukes in 1955, researchers have not been able to identify the causative etiologic agent of BV. There is increasing evidence, however, that BV occurs when Lactobacillus spp., the predominant species in healthy vaginal flora, are replaced by anaerobic bacteria, such as Gardenella vaginalis, Mobiluncus curtisii, M. mulieris, other anaerobic bacteria and/or Mycoplasma hominis. Worldwide, it estimated that 20-30 % of women of reproductive age attending sexually transmitted infection (STI) clinics suffer from BV, and that its prevalence can be as high as 50-60 % in high-risk populations (e.g., those who practice commercial sex work (CSW). Epidemiological data show that women are more likely to report BV if they: 1) have had a higher number of lifetime sexual partners; 2) are unmarried; 3) have engaged in their first intercourse at a younger age; 4) have engaged in CSW, and 5) practice regular douching. In the past decade, several studies have provided evidence on the contribution of sexual activity to BV. However, it is difficult to state that BV is a STI without being able to identify the etiologic agent. BV has also emerged as a public health problem due to its association with other STIs, including: human immunodeficiency virus (HIV), herpes simplex virus type 2 (HSV-2), Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG). The most recent evidence on the association between BV and CT/NG infection comes from two secondary analyses of cohort data conducted among women attending STI clinics. Based on these studies, women with BV had a 1.8 and 1.9-fold increased risk for NG and CT infection, respectively. Taken together, BV is likely a risk factor or at least an important contributor to subsequent NG or CT infection in high-risk women. Additional research is required to determine whether this association is also present in other low-risk sexually active populations, such as among women in the US military. It is essential to conduct large scale cross-sectional or population-based case-control studies to investigate the role of BV as a risk factor for CT/NG infections. These studies could lead to the development of interventions aimed at reducing the burden associated with bacterial STIs worldwide. C1 [Bautista, Christian T.; Morris, Sara; Hollingsworth, Bruce] Univ Lancaster, Div Hlth Res, Lancaster, England. [Wurapa, Eyako; Sateren, Warren B.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Sanchez, Jose L.] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD USA. [Sanchez, Jose L.] Cherokee Nation Technol Solut, Silver Spring, MD USA. RP Bautista, CT (reprint author), Univ Lancaster, Div Hlth Res, Lancaster, England. EM m.bautista@lancaster.ac.uk NR 95 TC 3 Z9 3 U1 10 U2 12 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 2054-9369 J9 MILITARY MED RES JI MILITARY MED. RES. PD FEB 13 PY 2016 VL 3 AR UNSP 4 DI 10.1186/s40779-016-0074-5 PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA DU3AW UT WOS:000382084100001 PM 26877884 ER PT J AU Mullins, AB Despain, KE Wallace, SM Honnold, CL Lent, EM AF Mullins, Anna B. Despain, Kenneth E. Wallace, Shannon M. Honnold, Cary L. Lent, Emily May TI Testicular effects of 3-nitro-1,2,4-triazol-5-one (NTO) in mice when exposed orally SO TOXICOLOGY MECHANISMS AND METHODS LA English DT Article DE 932-64-9; BALB; c; degeneration; IMX 101; insensitive munitions; mice; testicular effects ID RATS; TESTIS; PHTHALATE; TOXICITY; HISTOPATHOLOGY; ATROPHY; ETHER AB 3-Nitro-1,2,4-triazol-5-one (NTO) is currently being investigated in the development of insensitive munitions. Rats orally exposed to NTO have demonstrated testicular toxicity in both subacute and subchronic studies; however, toxicity has not been verified in mice. Also, previous studies have not demonstrated the nature of NTO-induced testicular toxicity due to the prolonged dosing regimen utilized and effects of maturation depletion. In this study, a time-course design was used and the earliest pathological changes in testes of adult BALB/c mice orally dosed with NTO in corn oil suspensions at 0, 500 or 1000mg/kg-day NTO for 1, 3, 7 or 14 d were evaluated. The earliest NTO-induced testicular changes occurred in the 1000mg/kg-day group at day 7 and the 500mg/kg-day group at day 14 as evident by the presence of bi- and multinucleated giant cells (MNGCs) of almost all spermatids in an isolated stage II-III tubule/step 2-3 and a stage IX tubule/step 9 in the 1000 and 500mg/kg-day groups, respectively. Testicular toxicity was characterized by degeneration and the presence of bi- and MNGCs of spermatids (stages II-III and IX), which progressed to additional germ cell degeneration as dosing duration increased. Occasional step 16 spermatid retention was also noted in stage XII and I tubules in the day 14, 1000mg/kg-day group. These data indicate that NTO is a testicular toxicant in mice and that spermatids are the most sensitive cell. The presence of retained spermatids warrants further investigation regarding NTO's role as a direct Sertoli cell toxicant. C1 [Mullins, Anna B.; Despain, Kenneth E.; Wallace, Shannon M.; Honnold, Cary L.] Walter Reed Army Inst Res, Vet Serv Program, Naval Med Res Ctr, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. [Lent, Emily May] US Army Publ Hlth Command, Army Inst Publ Hlth, Aberdeen Proving Ground, MD USA. RP Mullins, AB (reprint author), Walter Reed Army Inst Res, Vet Serv Program, Naval Med Res Ctr, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM anna.b.mullins2.mil@mail.mil FU Strategic Environmental Research and Development Program (SERDP) [ER-2223] FX This work was supported by funding from the Strategic Environmental Research and Development Program (SERDP Project ER-2223). The authors declare no competing interests. Material has been reviewed by the Walter Reed Army Institute of Research. There is no objection to its presentation and/or publication. The opinions or assertions contained herein are the private views of the author, and are not to be construed as official, or as reflecting true view of the Department of the Army or the Department of Defense. NR 25 TC 0 Z9 0 U1 1 U2 4 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1537-6516 EI 1537-6524 J9 TOXICOL MECH METHOD JI Toxicol. Mech. Methods PD FEB 12 PY 2016 VL 26 IS 2 BP 97 EP 103 DI 10.3109/15376516.2015.1118175 PG 7 WC Toxicology SC Toxicology GA DI5GX UT WOS:000373528000004 PM 26804465 ER PT J AU Belle, A Ansari, S Spadafore, M Convertino, VA Ward, KR Derksen, H Najarian, K AF Belle, Ashwin Ansari, Sardar Spadafore, Maxwell Convertino, Victor A. Ward, Kevin R. Derksen, Harm Najarian, Kayvan TI A Signal Processing Approach for Detection of Hemodynamic Instability before Decompensation SO PLOS ONE LA English DT Article ID HEART-RATE-VARIABILITY; COMPLEX WAVELETS; BLOOD-PRESSURE; HEMORRHAGE; MORTALITY AB Advanced hemodynamic monitoring is a critical component of treatment in clinical situations where aggressive yet guided hemodynamic interventions are required in order to stabilize the patient and optimize outcomes. While there are many tools at a physician's disposal to monitor patients in a hospital setting, the reality is that none of these tools allow hi-fidelity assessment or continuous monitoring towards early detection of hemodynamic instability. We present an advanced automated analytical system which would act as a continuous monitoring and early warning mechanism that can indicate pending decompensation before traditional metrics can identify any clinical abnormality. This system computes novel features or bio-markers from both heart rate variability (HRV) as well as the morphology of the electrocardiogram (ECG). To compare their effectiveness, these features are compared with the standard HRV based bio-markers which are commonly used for hemodynamic assessment. This study utilized a unique database containing ECG waveforms from healthy volunteer subjects who underwent simulated hypovolemia under controlled experimental settings. A support vector machine was utilized to develop a model which predicts the stability or instability of the subjects. Results showed that the proposed novel set of features outperforms the traditional HRV features in predicting hemodynamic instability. C1 [Belle, Ashwin; Ansari, Sardar; Ward, Kevin R.; Najarian, Kayvan] Univ Michigan, Dept Emergency Med, Ann Arbor, MI 48109 USA. [Belle, Ashwin; Ansari, Sardar; Ward, Kevin R.; Derksen, Harm; Najarian, Kayvan] Univ Michigan, Michigan Ctr Integrat Res Crit Care, Ann Arbor, MI 48109 USA. [Derksen, Harm] Univ Michigan, Dept Math, Ann Arbor, MI 48109 USA. [Najarian, Kayvan] Univ Michigan, Dept Computat Med & Bioinformat, Ann Arbor, MI 48109 USA. [Spadafore, Maxwell] Univ Michigan, Coll Literature Sci & Arts, Ann Arbor, MI 48109 USA. [Convertino, Victor A.] US Army Inst Surg Res, Combat Casualty Care Res Program, San Antonio, TX USA. RP Belle, A (reprint author), Univ Michigan, Dept Emergency Med, Ann Arbor, MI 48109 USA.; Belle, A (reprint author), Univ Michigan, Michigan Ctr Integrat Res Crit Care, Ann Arbor, MI 48109 USA. EM bellea@med.umich.edu FU U.S. Army Medical Research and Material Command Combat Casualty Care Research Program [05-0033-02] FX Initial work of this project was funded by: U.S. Army Medical Research and Material Command Combat Casualty Care Research Program, Grant: 05-0033-02: KN KW. The authors had no role in the design of experimental setup and data collection for the LBNP study. The LBNP study was designed and data was collected by USASR which partially funded the project in the early stages. NR 39 TC 0 Z9 0 U1 1 U2 1 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD FEB 12 PY 2016 VL 11 IS 2 AR e0148544 DI 10.1371/journal.pone.0148544 PG 20 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DD6SI UT WOS:000370054100035 PM 26871715 ER PT J AU Huang, YM Rueda, LM AF Huang, Yiau-Min Rueda, Leopoldo M. TI A pictorial key to the sections, groups, and species of the Aedes (Diceromyia) in the Afrotropical Region (Diptera: Culicidae) SO ZOOTAXA LA English DT Article DE Culicidae; mosquitoes; identification key; Aedes; Africa ID YELLOW-FEVER VIRUS; SOUTHEASTERN SENEGAL; CHIKUNGUNYA OUTBREAK; SOUTHERN RHODESIA; FURCIFER-TAYLORI; MOSQUITOS; DENGUE-2; EPIDEMIC AB Nine species of the subgenus Diceromyia Theobald of genus Aedes Meigen in the Afrotropical Region are treated in a pictorial key based on diagnostic morphological features. Images of the diagnostic morphological structures of the adult head, thorax, abdomen, leg and wing are included. The medical importance of the Furcifer Group species in Africa was briefly reviewed. C1 [Huang, Yiau-Min] Smithsonian Inst, Dept Entomol, POB 37012,MSC C1109,MRC 534, Washington, DC 20013 USA. [Rueda, Leopoldo M.] Walter Reed Army Inst Res, Entomol Branch, Walter Reed Biosystemat Unit, Silver Spring, MD 20910 USA. [Rueda, Leopoldo M.] Smithsonian Inst, Walter Reed Biosystemat Unit, Museum Support Ctr, MRC 534,4210 Silver Hill Rd, Suitland, MD 20746 USA. RP Huang, YM (reprint author), Smithsonian Inst, Dept Entomol, POB 37012,MSC C1109,MRC 534, Washington, DC 20013 USA.; Rueda, LM (reprint author), Walter Reed Army Inst Res, Entomol Branch, Walter Reed Biosystemat Unit, Silver Spring, MD 20910 USA.; Rueda, LM (reprint author), Smithsonian Inst, Walter Reed Biosystemat Unit, Museum Support Ctr, MRC 534,4210 Silver Hill Rd, Suitland, MD 20746 USA. EM huangy@si.edu; ruedapol@si.edu NR 35 TC 0 Z9 0 U1 0 U2 3 PU MAGNOLIA PRESS PI AUCKLAND PA PO BOX 41383, AUCKLAND, ST LUKES 1030, NEW ZEALAND SN 1175-5326 EI 1175-5334 J9 ZOOTAXA JI Zootaxa PD FEB 11 PY 2016 VL 4079 IS 2 BP 281 EP 290 PG 10 WC Zoology SC Zoology GA DD7UC UT WOS:000370128900009 PM 27396006 ER PT J AU Kiziltas, A Nazari, B Kiziltas, EE Gardner, DJS Han, Y Rushing, TS AF Kiziltas, Alper Nazari, Behzad Kiziltas, Esra Erbas Gardner, Douglas J. S. Han, Yousoo Rushing, Todd S. TI Cellulose NANOFIBER-polyethylene nanocomposites modified by polyvinyl alcohol SO JOURNAL OF APPLIED POLYMER SCIENCE LA English DT Article DE cellulose and other wood products; manufacturing; rheology; thermogravimetric analysis; thermoplastics ID FILLED POLYPROPYLENE COMPOSITES; NYLON 6 COMPOSITES; MECHANICAL-PROPERTIES; THERMAL-ANALYSIS; WHISKERS; WOOD; ULTRASONICATION; ACID/CELLULOSE; NANOCRYSTALS; MORPHOLOGY AB The uniform dispersion of cellulose nanofibers (CNFs) in non-polar polymer matrices is a primary problem to overcome in creating novel nanocomposites from these materials. The aim of this study was to produce CNF-polyethylene (PE) nanocomposites by melt compounding followed by injection molding to investigate the possibility of using polyvinyl alcohol (PVA) to improve the dispersion of CNF in the PE matrix. The tensile strength of CNF- filled composites was 17.4 MPa with the addition of 5 wt % CNF-PVA, which was 25% higher than the strength of neat PE. The tensile modulus of elasticity increased by 40% with 5% CNF-PVA addition. Flexural properties also significantly increased with increased CNF loading. Shear viscosity increased with increasing CNF content. The elastic moduli of the PE/CNF composites from rheological measurements were greater than those of the neat PE matrix because of the intrinsic rigidity of CNF. Melt creep compliance decreased by about 13% and 45% for the composites with 5 wt % CNF and 10 wt % CNF, respectively. It is expected that the PVA carrier system can contribute to the development of a process methodology to effectively disperse CNFs containing water in a polymer matrix. (c) 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 42933. C1 [Kiziltas, Alper; Kiziltas, Esra Erbas; Gardner, Douglas J. S.; Han, Yousoo] Univ Maine, Adv Struct & Composites Ctr AEWC, Orono, ME 04469 USA. [Kiziltas, Alper] Univ Bartin, Dept Forest Ind Engn, Fac Forestry, TR-74100 Bartin, Turkey. [Nazari, Behzad] Univ Maine, Dept Chem Engn, Orono, ME 04469 USA. [Kiziltas, Esra Erbas; Gardner, Douglas J. S.] Sci & Technol Res Council Turkey TUBITAK, TR-06100 Ankara, Turkey. [Rushing, Todd S.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Kiziltas, A (reprint author), Univ Maine, Adv Struct & Composites Ctr AEWC, Orono, ME 04469 USA. EM kiziltasalper@gmail.com FU U.S. Army Engineer Research and Development Center [912HZ-07-2-0013]; Maine Agricultural and Forest Experiment Station (MAFES) project [ME09615-08M] FX The authors thank Chris West and Alex Nash for all of their hard work for production, characterization and material properties of the polymer nanocomposites. The authors also thank U.S. Army Engineer Research and Development Center project 912HZ-07-2-0013 and the Maine Agricultural and Forest Experiment Station (MAFES) project ME09615-08M. Permission to publish was granted by Director, Geotechnical and Structures Laboratory, at the U.S. Army Engineer Research and Development Center. NR 55 TC 3 Z9 3 U1 10 U2 82 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0021-8995 EI 1097-4628 J9 J APPL POLYM SCI JI J. Appl. Polym. Sci. PD FEB 10 PY 2016 VL 133 IS 6 AR 42933 DI 10.1002/app.42933 PG 8 WC Polymer Science SC Polymer Science GA CX2JX UT WOS:000365524100003 ER PT J AU Cho, JH Gao, JX AF Cho, Jin-Hee Gao, Jianxi TI Cyber War Game in Temporal Networks SO PLOS ONE LA English DT Article ID COMPLEX NETWORKS; INTERDEPENDENT NETWORKS AB In a cyber war game where a network is fully distributed and characterized by resource constraints and high dynamics, attackers or defenders often face a situation that may require optimal strategies to win the game with minimum effort. Given the system goal states of attackers and defenders, we study what strategies attackers or defenders can take to reach their respective system goal state (i.e., winning system state) with minimum resource consumption. However, due to the dynamics of a network caused by a node's mobility, failure or its resource depletion over time or action(s), this optimization problem becomes NP-complete. We propose two heuristic strategies in a greedy manner based on a node's two characteristics: resource level and influence based on k-hop reachability. We analyze complexity and optimality of each algorithm compared to optimal solutions for a small-scale static network. Further, we conduct a comprehensive experimental study for a large-scale temporal network to investigate best strategies, given a different environmental setting of network temporality and density. We demonstrate the performance of each strategy under various scenarios of attacker/defender strategies in terms of win probability, resource consumption, and system vulnerability. C1 [Cho, Jin-Hee] US Army Res Lab, Computat & Informat Sci Directorate, Adelphi, MD 20783 USA. [Gao, Jianxi] Northeastern Univ, Ctr Complex Network Res, Boston, MA 02115 USA. [Gao, Jianxi] Northeastern Univ, Dept Phys, Boston, MA 02115 USA. RP Gao, JX (reprint author), Northeastern Univ, Ctr Complex Network Res, Boston, MA 02115 USA.; Gao, JX (reprint author), Northeastern Univ, Dept Phys, Boston, MA 02115 USA. EM jianxi.gao@gmail.com RI gao, jianxi/I-1300-2013; Gao, Jianxi/C-8494-2015 OI gao, jianxi/0000-0002-3952-208X; Gao, Jianxi/0000-0002-3952-208X FU Army Research Laboratory via the Network Science Collaborative Technology Alliance (NS CTA) program [W911NF-09-2-0053]; John Templeton Foundation: Mathematical and Physical Sciences [PFI-777]; Defense Threat Reduction Agency Basic Research [HDTRA1-10-1-0100]; European Commission [FP7317532, 641191]; National Natural Science Foundation of China [61374160, 71201132] FX Research was, in part, for Dr. Jianxi Gao, sponsored by the Army Research Laboratory via the Network Science Collaborative Technology Alliance (NS CTA) program and was accomplished under Cooperative Agreement Number W911NF-09-2-0053. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. Dr. Jianxi Gao also acknowledges the support of the John Templeton Foundation: Mathematical and Physical Sciences grant number PFI-777; The Defense Threat Reduction Agency Basic Research Grant No. HDTRA1-10-1-0100; European Commission grant numbers FP7317532 (MULTIPLEX) and 641191 (CIMPLEX); and the National Natural Science Foundation of China (Grants 61374160 and 71201132). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 34 TC 0 Z9 0 U1 1 U2 7 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD FEB 9 PY 2016 VL 11 IS 2 AR e0148674 DI 10.1371/journal.pone.0148674 PG 16 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DD6MN UT WOS:000370038400063 PM 26859840 ER PT J AU Maneerattanasak, S Gosi, P Krudsood, S Tongshoob, J Lanteri, CA Snounou, G Khusmith, S AF Maneerattanasak, Sarunya Gosi, Panita Krudsood, Srivicha Tongshoob, Jarinee Lanteri, Charlotte A. Snounou, Georges Khusmith, Srisin TI Genetic diversity among Plasmodium vivax isolates along the Thai-Myanmar border of Thailand SO MALARIA JOURNAL LA English DT Article DE Plasmodium vivax; Genetic diversity; Multiplicity; Pvcsp; Pvmsp1; Pvmsp3a; Thailand ID MEROZOITE SURFACE PROTEIN-1; CIRCUMSPOROZOITE PROTEIN; REDUCED RISK; MALARIA; INFECTIONS; POLYMORPHISM; CHLOROQUINE; VARIANTS; CHILDREN; MARKERS AB Background: Knowledge of the population genetics and transmission dynamics of Plasmodium vivax is crucial in predicting the emergence of drug resistance, relapse pattern and novel parasite phenotypes, all of which are relevant to the control of vivax infections. The aim of this study was to analyse changes in the genetic diversity of P. vivax genes from field isolates collected at different times along the Thai-Myanmar border. Methods: Two hundred and fifty-four P. vivax isolates collected during two periods 10 years apart along the Thai-Myanmar border were analysed. The parasites were genotyped by nested-PCR and PCR-RFLP targeting selected polymorphic loci of Pvmsp1, Pvmsp3a and Pvcsp genes. Results: The total number of distinguishable allelic variants observed for Pvcsp, Pvmsp1, and Pvmsp3a was 17, 7 and 3, respectively. High genetic diversity was observed for Pvcsp (H-E = 0.846) and Pvmsp1 (H-E = 0.709). Of the 254 isolates, 4.3 and 14.6 % harboured mixed Pvmsp1 and Pvcsp genotypes with a mean multiplicity of infection (MOI) of 1.06 and 1.15, respectively. The overall frequency of multiple genotypes was 16.9 %. When the frequencies of allelic variants of each gene during the two distinct periods were analysed, significant differences were noted for Pvmsp1 (P = 0.018) and the Pvcsp (P = 0.033) allelic variants. Conclusion: Despite the low malaria transmission levels in Thailand, P. vivax population exhibit a relatively high degree of genetic diversity along the Thai-Myanmar border of Thailand, in particular for Pvmsp1 and Pvcsp, with indication of geographic and temporal variation in frequencies for some variants. These results are of relevance to monitoring the emergence of drug resistance and to the elaboration of measures to control vivax malaria. C1 [Maneerattanasak, Sarunya; Tongshoob, Jarinee; Khusmith, Srisin] Mahidol Univ, Fac Trop Med, Dept Microbiol & Immunol, 420-6 Rajvithi Rd, Bangkok 10400, Thailand. [Gosi, Panita; Lanteri, Charlotte A.] US Army Mil Component, Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok, Thailand. [Krudsood, Srivicha] Mahidol Univ, Fac Trop Med, Clin Malaria Res Unit, Bangkok, Thailand. [Snounou, Georges] Univ Paris 06, Sorbonne Univ, UPMC UMRS CR7, F-75005 Paris, France. [Snounou, Georges] CNRS ERL 8255, CIMI Paris, Inserm U1135, F-75013 Paris, France. [Khusmith, Srisin] Mahidol Univ, Ctr Emerging & Neglected Infect Dis, Bangkok 10700, Thailand. RP Khusmith, S (reprint author), Mahidol Univ, Fac Trop Med, Dept Microbiol & Immunol, 420-6 Rajvithi Rd, Bangkok 10400, Thailand.; Khusmith, S (reprint author), Mahidol Univ, Ctr Emerging & Neglected Infect Dis, Bangkok 10700, Thailand. EM srisin.khu@mahidol.ac.th FU Royal Golden Jubilee Ph.D. Program (RGJ) of the Thailand Research Fund [PHD/0095/2554]; Office of Higher Education Commission, Ministry of Education, Thailand; Faculty of Tropical Medicine, Mahidol University; Mahidol University under the National Research Universities Initiative FX We wish to thank Clinical Malaria Research Unit, Faculty of Tropical Medicine, Mahidol University for providing stored blood samples. We thank Somporn Krasaesub, Department of Administration, Armed Forces Research Institute of Medical Sciences (AFRIMS), Bangkok, Thailand for providing suggestions for data analysis. This study is supported by the Royal Golden Jubilee Ph.D. Program (RGJ) of the Thailand Research Fund, Grant No. PHD/0095/2554; the Office of Higher Education Commission, Ministry of Education, Thailand, Mahidol University under the National Research Universities Initiative; and the Faculty of Tropical Medicine, Mahidol University. NR 43 TC 1 Z9 1 U1 3 U2 11 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD FEB 9 PY 2016 VL 15 AR 75 DI 10.1186/s12936-016-1136-6 PG 8 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA DC9VG UT WOS:000369569100002 PM 26858120 ER PT J AU Xu, YF Bailey, E Spackman, E Li, T Wang, H Long, LP Baroch, JA Cunningham, FL Lin, XX Jarman, RG DeLiberto, TJ Wan, XF AF Xu, Yifei Bailey, Elizabeth Spackman, Erica Li, Tao Wang, Hui Long, Li-Ping Baroch, John A. Cunningham, Fred L. Lin, Xiaoxu Jarman, Richard G. DeLiberto, Thomas J. Wan, Xiu-Feng TI Limited Antigenic Diversity in Contemporary H7 Avian-Origin Influenza A Viruses from North America SO SCIENTIFIC REPORTS LA English DT Article ID PATTERN-RECOGNITION RECEPTORS; PHYLOGENETIC ANALYSIS; LOW-PATHOGENICITY; UNITED-STATES; INTERSPECIES TRANSMISSION; COMMERCIAL POULTRY; BRITISH-COLUMBIA; DOMESTIC POULTRY; INNATE IMMUNITY; WILD BIRDS AB Subtype H7 avian-origin influenza A viruses (AIVs) have caused at least 500 confirmed human infections since 2003 and culling of >75 million birds in recent years. Here we antigenically and genetically characterized 93 AIV isolates from North America (85 from migratory waterfowl [1976-2010], 7 from domestic poultry [1971-2012], and 1 from a seal [1980]). The hemagglutinin gene of these H7 viruses are separated from those from Eurasia. Gradual accumulation of nucleotide and amino acid substitutions was observed in the hemagglutinin of H7 AIVs from waterfowl and domestic poultry. Genotype characterization suggested that H7 AIVs in wild birds form diverse and transient internal gene constellations. Serologic analyses showed that the 93 isolates cross-reacted with each other to different extents. Antigenic cartography showed that the average antigenic distance among them was 1.14 units (standard deviation [SD], 0.57 unit) and that antigenic diversity among the H7 isolates we tested was limited. Our results suggest that the continuous genetic evolution has not led to significant antigenic diversity for H7 AIVs from North America. These findings add to our understanding of the natural history of IAVs and will inform public health decision-making regarding the threat these viruses pose to humans and poultry. C1 [Xu, Yifei; Bailey, Elizabeth; Wang, Hui; Long, Li-Ping; Wan, Xiu-Feng] Mississippi State Univ, Coll Vet Med, Dept Basic Sci, Mississippi State, MS 39762 USA. [Spackman, Erica] ARS, Exot & Emerging Avian Viral Dis Unit, Southeast Poultry Res Lab, US Natl Poultry Res Ctr,USDA, Athens, GA USA. [Li, Tao; Lin, Xiaoxu; Jarman, Richard G.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD USA. [Baroch, John A.; DeLiberto, Thomas J.] USDA, Natl Wildlife Res Ctr, Wildlife Serv, Anim & Plant Hlth Inspect Serv, Ft Collins, CO USA. [Cunningham, Fred L.] USDA, Mississippi Field Stn, Natl Wildlife Res Ctr, Wildlife Serv,Anim & Plant Hlth Inspect Serv, Mississippi State, MS USA. RP Wan, XF (reprint author), Mississippi State Univ, Coll Vet Med, Dept Basic Sci, Mississippi State, MS 39762 USA. EM wan@cvm.msstate.edu FU NIH/NIAID [R01 AI116744]; Department of Defense (DoD) Global Emerging Infections Surveillance and Response System (GEIS), a Division of the Armed Forces Health Surveillance Center [P0172] FX We thank Nan Zhao and Lucy Senter for technical assistance with this project. This project was supported partially by NIH/NIAID grant no. R01 AI116744 to XFW and by funding from the Department of Defense (DoD) Global Emerging Infections Surveillance and Response System (GEIS), a Division of the Armed Forces Health Surveillance Center grant no. P0172 to RGJ and XL. NR 70 TC 1 Z9 1 U1 1 U2 11 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD FEB 9 PY 2016 VL 6 AR 20688 DI 10.1038/srep20688 PG 17 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DD0MT UT WOS:000369614800001 PM 26858078 ER PT J AU Das, S Dubey, M Roelofs, A AF Das, Saptarshi Dubey, Madan Roelofs, Andreas TI High gain, low noise, fully complementary logic inverter based on bi-layer WSe2 field effect transistors (vol 105, 083511, 2014) SO APPLIED PHYSICS LETTERS LA English DT Correction C1 [Das, Saptarshi; Roelofs, Andreas] Argonne Natl Lab, Ctr Nanoscale Mat, Argonne, IL 60439 USA. [Dubey, Madan] US Army, Res Lab, Adelphi, MD 20783 USA. RP Das, S (reprint author), Argonne Natl Lab, Ctr Nanoscale Mat, Argonne, IL 60439 USA. NR 1 TC 0 Z9 0 U1 6 U2 9 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD FEB 8 PY 2016 VL 108 IS 6 AR 069902 DI 10.1063/1.4941819 PG 1 WC Physics, Applied SC Physics GA DH8PJ UT WOS:000373056300061 ER PT J AU Derrick, TR Edwards, WB Fellin, RE Seay, JF AF Derrick, Timothy R. Edwards, W. Brent Fellin, Rebecca E. Seay, Joseph F. TI An integrative modeling approach for the efficient estimation of cross sectional tibial stresses during locomotion SO JOURNAL OF BIOMECHANICS LA English DT Article DE Finite element method; Internal bone moments; Bone models; Beam theory; Strain gage ID INHOMOGENEOUS MATERIAL PROPERTIES; SHEAR STRESSES; BONE; FRACTURES; TRANSVERSE; DENSITY; LOADS AB The purpose of this research was to utilize a series of models to estimate the stress in a cross section of the tibia, located 62% from the proximal end, during walking. Twenty-eight male, active duty soldiers walked on an instrumented treadmill while external force data and kinematics were recorded. A rigid body model was used to estimate joint moments and reaction forces. A musculoskeletal model was used to gather muscle length, muscle velocity, moment arm and orientation information. Optimization procedures were used to estimate muscle forces and finally internal bone forces and moments were applied to an inhomogeneous, subject specific bone model obtained from CT scans to estimate stress in the bone cross section. Validity was assessed by comparison to stresses calculated from strain gage data in the literature and sensitivity was investigated using two simplified versions of the bone model-a homogeneous model and an ellipse approximation. Peak compressive stress occurred on the posterior aspect of the cross section ( -47.5 +/- 14.9 MPa). Peak tensile stress occurred on the anterior aspect (27.0 +/- 11.7 MPa) while the location of peak shear was variable between subjects (7.2 +/- 2.4 MPa). Peak compressive, tensile and shear stresses were within 0.52 MPa, 0.36 MPa and 3.02 MPa respectively of those calculated from the converted strain gage data. Peak values from a inhomogeneous model of the bone correlated well with homogeneous model (normal: 0.99; shear: 0.94) as did the normal ellipse model (r=0.89-0.96). However, the relationship between shear stress in the inhomogeneous model and ellipse model was less accurate (r=0.64). The procedures detailed in this paper provide a non-invasive and relatively quick method of estimating cross sectional stress that holds promise for assessing injury and osteogenic stimulus in bone during normal physical activity. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Derrick, Timothy R.] Iowa State Univ, Dept Kinesiol, Ames, IA 50011 USA. [Edwards, W. Brent] Univ Calgary, Fac Kinesiol, Calgary, AB, Canada. [Fellin, Rebecca E.; Seay, Joseph F.] US Army, Environm Med Res Inst, Natick, MA 01760 USA. RP Derrick, TR (reprint author), Iowa State Univ, 249 Forker Bldg, Ames, IA 50011 USA. EM tderrick@iastate.edu NR 24 TC 1 Z9 1 U1 2 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0021-9290 EI 1873-2380 J9 J BIOMECH JI J. Biomech. PD FEB 8 PY 2016 VL 49 IS 3 BP 429 EP 435 DI 10.1016/j.jblomech.2016.01.003 PG 7 WC Biophysics; Engineering, Biomedical SC Biophysics; Engineering GA DF7PA UT WOS:000371548700017 PM 26803338 ER PT J AU Binder, R Roberts, AT Kwong, NH Sandhu, A Everitt, HO AF Binder, Rolf Roberts, Adam T. Kwong, Nai H. Sandhu, Arvinder Everitt, Henry O. TI Global k-space analysis of electron-phonon interaction in graphene and application to M-point spectroscopy SO PHYSICAL REVIEW B LA English DT Article ID FANO-RESONANT METASURFACES; FEW-LAYER GRAPHENE; RAMAN-SPECTROSCOPY; BILAYER GRAPHENE; GRAPHITE; DYNAMICS; LIGHT AB Recently, optical probes have become available that can access and observe energy renormalization due to electron-phonon interaction in graphene away from the well-studied Dirac K point. Using an expanded deformation potential approach, we present a theoretical study of the electron-phonon self-energy and scattering matrix elements across the entire Brillouin zone. We elucidate the roles of modulated hopping and conventional deformation potential coupling, parameterized via standard deformation potentials, the in-plane phonon modes, intra- and interband contributions, and umklapp processes. Applying the theory to nonlinear optical transmission spectroscopy in the vicinity of the M point, we find very good agreement with recently published experimental data. C1 [Binder, Rolf; Roberts, Adam T.; Kwong, Nai H.; Sandhu, Arvinder] Univ Arizona, Coll Opt Sci, Tucson, AZ 85721 USA. [Binder, Rolf; Sandhu, Arvinder] Univ Arizona, Dept Phys, Tucson, AZ 85721 USA. [Roberts, Adam T.; Everitt, Henry O.] US Army Aviat & Missile Res, Ctr Dev & Engn, Redstone Arsenal, AL 35898 USA. [Everitt, Henry O.] Duke Univ, Dept Phys, Durham, NC 27708 USA. RP Binder, R (reprint author), Univ Arizona, Coll Opt Sci, Tucson, AZ 85721 USA.; Binder, R (reprint author), Univ Arizona, Dept Phys, Tucson, AZ 85721 USA. NR 100 TC 0 Z9 0 U1 12 U2 18 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2469-9950 EI 2469-9969 J9 PHYS REV B JI Phys. Rev. B PD FEB 8 PY 2016 VL 93 IS 8 AR 085414 DI 10.1103/PhysRevB.93.085414 PG 18 WC Physics, Condensed Matter SC Physics GA DD2BW UT WOS:000369728400007 ER PT J AU Wang, GX Loh, GC Pandey, R Karna, SP AF Wang, Gaoxue Loh, G. C. Pandey, Ravindra Karna, Shashi P. TI Out-of-plane structural flexibility of phosphorene SO NANOTECHNOLOGY LA English DT Article DE phosphorene; buckling; structural flexibility; molecular dynamics; density functional theory ID FIELD-EFFECT TRANSISTORS; LAYER BLACK PHOSPHORUS; MONOLAYER GRAPHENE; MOLECULAR-DYNAMICS; HIGH-QUALITY; MEMBRANES; STRAIN AB Phosphorene has been rediscovered recently, establishing itself as one of the most promising two-dimensional group-V elemental monolayers with direct band gap, high carrier mobility, and anisotropic electronic properties. In this paper, surface buckling and its effect on its electronic properties are investigated by using molecular dynamics simulations together with density functional theory calculations. We find that phosphorene shows superior structural flexibility along the armchair direction allowing it to have large curvatures. The semiconducting and direct band gap nature are retained with buckling along the armchair direction; the band gap decreases and transforms to an indirect band gap with buckling along the zigzag direction. The structural flexibility and electronic robustness along the armchair direction facilitate the fabrication of devices with complex shapes, such as folded phosphorene and phosphorene nano-scrolls, thereby offering new possibilities for the application of phosphorene in flexible electronics and optoelectronics. C1 [Wang, Gaoxue; Pandey, Ravindra] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. [Loh, G. C.] Inst High Performance Comp, 1 Fusionopolis Way,16-16 Connexis, Singapore 138632, Singapore. [Karna, Shashi P.] US Army Res Lab, Weap & Mat Res Directorate, ATTN RDRL WM, Aberdeen Proving Ground, MD 21005 USA. RP Wang, GX; Pandey, R (reprint author), Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA.; Karna, SP (reprint author), US Army Res Lab, Weap & Mat Res Directorate, ATTN RDRL WM, Aberdeen Proving Ground, MD 21005 USA. EM gaoxuew@mtu.edu; pandey@mtu.edu; shashi.p.karna.civ@mail.mil RI Wang, Gaoxue/C-9492-2017 OI Wang, Gaoxue/0000-0003-2539-3405 FU Army Research Office [W911NF-14-2-0088] FX RAMA and Superior, high performance computing clusters at Michigan Technological University, were used in obtaining results presented in this paper. Supports from Dr S Gowtham are acknowledged. Partial research support for this work from the Army Research Office, Contract # W911NF-14-2-0088 is gratefully acknowledged. NR 43 TC 13 Z9 13 U1 8 U2 62 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0957-4484 EI 1361-6528 J9 NANOTECHNOLOGY JI Nanotechnology PD FEB 5 PY 2016 VL 27 IS 5 AR 055701 DI 10.1088/0957-4484/27/5/055701 PG 7 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Science & Technology - Other Topics; Materials Science; Physics GA DC0GD UT WOS:000368894300015 ER PT J AU Luo, C Zhu, YJ Borodin, O Gao, T Fan, XL Xu, YH Xu, K Wang, CS AF Luo, Chao Zhu, Yujie Borodin, Oleg Gao, Tao Fan, Xiulin Xu, Yunhua Xu, Kang Wang, Chunsheng TI Activation of Oxygen-Stabilized Sulfur for Li and Na Batteries SO ADVANCED FUNCTIONAL MATERIALS LA English DT Article DE composites; electrochemical activation; lithium sulfur batteries; oxygen stabilized carbon; sulfur; oxygen-sulfur bonds; sodium sulfur batteries ID LITHIUM-ION BATTERIES; CATHODE MATERIAL; CYCLING STABILITY; CARBON NANOTUBES; S BATTERIES; PERFORMANCE; CELLS; COMPOSITE; GRAPHENE; ANODES AB The sulfur-based cathode materials suffer severely from poor cycling stability and low utilization, incurred by their stepwise reaction mechanism that generates polysulfide intermediates and the subsequent irreversible losses. In this work, those issues are significantly relieved by entrapping sulfur species in carbon host rich in oxygen functionalities. Sulfur species in such C/S composite are highly stabilized by their interaction with oxygen, and can deliver a reversible capacity of 508 mAh/(g of S) for 2000 cycles when coupled with Li, representing the best cycling stability up to date. More interestingly, extra capacity can be accessed by simply prelithiating the oxygen-stabilized C/S composites down to 0.6 V for a few cycles, which enables a high capacity of 1621 mAh/(g of S) that eventually stabilizes at 820 mAh/(g of S) for 600 cycles. The mechanism for this electrochemical activation process is investigated with both spectroscopic and electrochemical techniques, which reveal that the inactive sulfur bonded to oxygen is liberated in the initial deep lithiation precycles and becomes electrochemically active. The oxygen-stabilized sulfur can also be coupled with Na anode to form Na/S cell, confirming that the formation of S-O interaction in C/S composite generates promising sulfur-based cathode materials for Li-S and Na-S batteries. C1 [Luo, Chao; Zhu, Yujie; Gao, Tao; Fan, Xiulin; Xu, Yunhua; Wang, Chunsheng] Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA. [Borodin, Oleg; Xu, Kang] US Army, Res Lab, Electrochem Branch, Adelphi, MD 20783 USA. RP Wang, CS (reprint author), Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA.; Xu, K (reprint author), US Army, Res Lab, Electrochem Branch, Adelphi, MD 20783 USA. EM conrad.k.xu.civ@mail.mil; cswang@umd.edu RI Wang, Chunsheng/H-5767-2011 OI Wang, Chunsheng/0000-0002-8626-6381 FU Army Research Office [W911NF10200]; Maryland Nano Center; NispLab; NSF as a MRSEC Shared Experimental Facility FX This work was supported by the Army Research Office under Contract No. W911NF10200. The authors acknowledge the support of the Maryland Nano Center and its NispLab. The NispLab is supported in part by the NSF as a MRSEC Shared Experimental Facility. The authors acknowledge Dr. Cynthia Lundgren and Dr. Karen Gaskell for the technique support. NR 36 TC 13 Z9 13 U1 40 U2 135 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 1616-301X EI 1616-3028 J9 ADV FUNCT MATER JI Adv. Funct. Mater. PD FEB 2 PY 2016 VL 26 IS 5 BP 745 EP 752 DI 10.1002/adfm.201503918 PG 8 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA DD5MX UT WOS:000369969100011 ER PT J AU Pelin, M Forino, M Brovedani, V Tartaglione, L Dell'Aversano, C Pistocchi, R Poli, M Sosa, S Florio, C Ciminiello, P Tubaro, A AF Pelin, Marco Forino, Martino Brovedani, Valentina Tartaglione, Luciana Dell'Aversano, Carmela Pistocchi, Rossella Poli, Mark Sosa, Silvio Florio, Chiara Ciminiello, Patrizia Tubaro, Aurelia TI Ovatoxin-a, A Palytoxin Analogue Isolated from Ostreopsis cf. ovata Fukuyo: Cytotoxic Activity and ELISA Detection SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID RESOLUTION MASS-SPECTROMETRY; FRENCH MEDITERRANEAN COAST; PUTATIVE PALYTOXIN; STRUCTURE ELUCIDATION; TOXIN PROFILE; MARINE TOXIN; HACAT CELLS; OSTREOCIN-D; SEA; ACCUMULATION AB This study provides the first evaluation of the cytotoxic effects of the recently identified palytoxin (PLTX) analog, ovatoxin-a (OVTX-a), the major toxin produced by Ostreopsis cf. ovata in the Mediterranean Sea. Its increasing detection during Ostreopsis blooms and in seafood highlights the need to characterize its toxic effects and to set up appropriate detection methods. OVTX-a is about 100 fold less potent than PLTX in reducing HaCaT cells viability (EC50 = 1.1 X 10(-9) M vs 1.8 X 10(-11) M, MTT test) in agreement with a reduced binding affinity (Kd = 1.2 X 10(-9) vs 2.7 X 10(-11) M, saturation experiments on intact cells). Similarly, OVTX-a hemolytic effect is lower than that of the reference PLTX compound. OstD shows the lowest cytotoxicity toward HaCaT keratinocytes, suggesting the lack of a hydroxyl group at C44 as a critical feature for PLTXs cytotoxic effects. A sandwich ELISA developed for PLTX detects also OVTX-a in a sensitive (LOD = 4.2 and LOQ = 5.6 ng/mL) and accurate manner (Bias = 0.3%), also in 0. cf. ovata extracts and contaminated mussels. Although in vitro OVTXa appears less toxic than PLTX, its cytotoxicity at nanomolar concentrations after short exposure time rises some concern for human health. The sandwich ELISA can be a viable screening method for OVTXs detection in monitoring program. C1 [Pelin, Marco; Brovedani, Valentina; Sosa, Silvio; Florio, Chiara; Tubaro, Aurelia] Univ Trieste, Dept Life Sci, Via A Valerio 6, I-34127 Trieste, Italy. [Forino, Martino; Tartaglione, Luciana; Dell'Aversano, Carmela; Ciminiello, Patrizia] Univ Naples Federico II, Dept Pharm, I-80131 Naples, Italy. [Pistocchi, Rossella] Univ Bologna, Interdept Ctr Res Environm Sci, I-481230 Ravenna, Italy. [Poli, Mark] US Army Med Res, Inst Infect Dis, Ft Detrick, MD 21701 USA. RP Tubaro, A (reprint author), Univ Trieste, Dept Life Sci, Via A Valerio 6, I-34127 Trieste, Italy. EM tubaro@units.it FU University of Trieste (Universita degli Studi di Trieste - Finanziamento di Ateneo per progetti di ricerca scientifica - FRA); University of Naples; Compagnia di San Paolo FX This work was supported by a grant of the University of Trieste (Universita degli Studi di Trieste - Finanziamento di Ateneo per progetti di ricerca scientifica - FRA 2012). Chemical analyses were carried out in the framework of Programme STAR Linea 1 2013 (VALTOX, Napoli_cal12013_08) financially supported by University of Naples and Compagnia di San Paolo. The authors are grateful to Prof. Takeshi Yasumoto (Japan Food Research Laboratories) for kindly supply ostreocin-D. NR 40 TC 4 Z9 5 U1 6 U2 20 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD FEB 2 PY 2016 VL 50 IS 3 BP 1544 EP 1551 DI 10.1021/acs.est.5b04749 PG 8 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA DC8LO UT WOS:000369471300054 PM 26714047 ER PT J AU Krakauer, T Pradhan, K Stiles, BG AF Krakauer, Teresa Pradhan, Kisha Stiles, Bradley G. TI Staphylococcal Superantigens Spark Host-Mediated Danger Signals SO FRONTIERS IN IMMUNOLOGY LA English DT Review DE SEB; superantigens; toxic shock; damage response; therapy; animal models ID TOXIC-SHOCK-SYNDROME; CLASS-II MOLECULES; COMPLEX CLASS-II; TUMOR-NECROSIS-FACTOR; INNATE IMMUNE-RESPONSE; T-CELL-ACTIVATION; CYTOKINE GENE-EXPRESSION; BLOOD MONONUCLEAR-CELLS; INDUCED LETHAL SHOCK; AUREUS CA-MRSA AB Staphylococcal enterotoxin B (SEB) of Staphylococcus aureus, and related superantigenic toxins produced by myriad microbes, are potent stimulators of the immune system causing a variety of human diseases from transient food poisoning to lethal toxic shock. These protein toxins bind directly to specific V beta regions of T-cell receptors (TCR) and major histocompatibility complex (MHC) class II on antigen-presenting cells, resulting in hyperactivation of T lymphocytes and monocytes/macrophages. Activated host cells produce excessive amounts of proinflammatory cytokines and chemokines, especially tumor necrosis factor alpha, interleukin 1 (IL-1), IL-2, interferon gamma (IFN gamma), and macrophage chemoattractant protein 1 causing clinical symptoms of fever, hypotension, and shock. Because of superantigen-induced T cells skewed toward TH1 helper cells, and the induction of proinflammatory cytokines, superantigens can exacerbate autoimmune diseases. Upon TCR/MHC ligation, pathways induced by superantigens include the mitogen-activated protein kinase cascades and cytokine receptor signaling, resulting in activation of NF kappa B and the phosphoinositide 3-kinase/mammalian target of rapamycin pathways. Various mouse models exist to study SEB-induced shock including those with potentiating agents, transgenic mice and an "SEB-only" model. However, therapeutics to treat toxic shock remain elusive as host response genes central to pathogenesis of superantigens have only been identified recently. Gene profiling of a murine model for SEB-induced shock reveals novel molecules upregulated in multiple organs not previously associated with SEB-induced responses. The pivotal genes include intracellular DNA/RNA sensors, apoptosis/DNA damage-related molecules, immunoproteasome components, as well as antiviral and IFN-stimulated genes. The host-wide induction of these, and other, antimicrobial defense genes provide evidence that SEB elicits danger signals resulting in multi-organ damage and toxic shock. Ultimately, these discoveries might lead to novel therapeutics for various superantigen-based diseases. C1 [Krakauer, Teresa] US Army Med Res Inst Infect Dis, Dept Immunol, Mol Translat Sci Div, Frederick, MD USA. [Pradhan, Kisha; Stiles, Bradley G.] Wilson Coll, Dept Biol, Chambersburg, PA USA. RP Krakauer, T (reprint author), US Army Med Res Inst Infect Dis, Dept Immunol, Mol Translat Sci Div, Frederick, MD USA.; Stiles, BG (reprint author), Wilson Coll, Dept Biol, Chambersburg, PA USA. EM teresa.krakauer.civ@mail.mil; brad.stiles@wilson.edu FU DTRA FX We thank DTRA for funding. Brad Stiles acknowledges Wilson College for the continuing support of this, and many other, endeavors. NR 182 TC 1 Z9 1 U1 4 U2 22 PU FRONTIERS MEDIA SA PI LAUSANNE PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLAND SN 1664-3224 J9 FRONT IMMUNOL JI Front. Immunol. PD FEB 2 PY 2016 VL 7 AR 23 DI 10.3389/fimmu.2016.00023 PG 14 WC Immunology SC Immunology GA DC3HW UT WOS:000369111400003 PM 26870039 ER PT J AU Katlein, C Perovich, DK Nicolaus, M AF Katlein, Christian Perovich, Donald K. Nicolaus, Marcel TI Geometric Effects of an Inhomogeneous Sea Ice Cover on the under Ice Light Field SO Frontiers in Earth Science LA English DT Article DE optics; irradiance; inherent optical properties; spatial variability; extinction coefficient ID TRANSMISSION; OCEAN; MELT AB Light measurements in the ocean provide crucial information about the energy fluxes in the climate and ecosystem. Currently radiative transfer problems are usually considered in horizontally homogeneous layers although it is known to be a crude assumption in many cases. In this paper, we examine the effects of a horizontally inhomogeneous sea ice layer on the light field in the water underneath. We implemented a three dimensional model, capable to simulate the light field underneath arbitrary surface geometries using ray optics. The results show clear effects of the measurement geometry on measured fluxes obtained with different sensor types, which need to be taken into account for the correct interpretation of the data. Radiance sensors are able to better sense the spatial variability of ice optical properties as compared to irradiance sensors. Furthermore, we show that the determination of the light extinction coefficient of water from vertical profiles is complicated under a horizontally inhomogeneous ice cover. This uncertainty in optical properties of the water, as well as the measurement geometry also limits the possibility to correct light measurements taken at depth for the influence of water in between the sea ice and the sensor. C1 [Katlein, Christian; Nicolaus, Marcel] Helmholtz Zentrum Polar & Meeresforsch, Alfred Wegener Inst, Sea Ice Phys, Bremerhaven, Germany. [Perovich, Donald K.] Cold Reg Res & Engn Lab, Hanover, NH USA. RP Katlein, C (reprint author), Helmholtz Zentrum Polar & Meeresforsch, Alfred Wegener Inst, Sea Ice Phys, Bremerhaven, Germany. EM christian.katlein@awi.de OI Katlein, Christian/0000-0003-2422-0414 FU graduate school POLMAR; Office of Naval Research; Alfred-Wegener-Institut Helmholtz-Zentrum fur Polar- und Meeresforschung FX CK thanks the graduate school POLMAR for granting an outgoing scholarship to visit DP which supported the writing of this manuscript. DP thanks the Office of Naval Research for their support. We thank R. Gerdes and two anonymous reviewers of an earlier version for comments on the manuscript. This study was funded by the Alfred-Wegener-Institut Helmholtz-Zentrum fur Polar- und Meeresforschung. The MATLAB code of the model used in this study is available at http://www.mathworks.com/matlabcentral/fileexchange/50566-geometric-ligh t-field-model. NR 26 TC 1 Z9 1 U1 0 U2 0 PU FRONTIERS MEDIA SA PI LAUSANNE PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLAND SN 2296-6463 J9 FRONT EARTH SCI JI Front. Earth Sci. PD FEB 2 PY 2016 VL 4 AR UNSP 6 DI 10.3389/feart.2016.00006 PG 10 WC Geosciences, Multidisciplinary SC Geology GA EJ2SW UT WOS:000393062400001 ER PT J AU Moser, RD Kurtis, KE Singh, PM Kahn, LF AF Moser, Robert D. Kurtis, Kimberly E. Singh, Preet M. Kahn, Lawrence F. TI Effect of sulfates on passivation in alkaline environments SO PROCEEDINGS OF THE INSTITUTION OF CIVIL ENGINEERS-CONSTRUCTION MATERIALS LA English DT Article DE concrete technology & manufacture; corrosion; materials technology ID SIMULATED PORE SOLUTIONS; STAINLESS-STEELS; CORROSION-RESISTANCE; BEHAVIOR AB Studies investigating passivation behaviour and corrosion resistance in simulated alkaline environments have typically been conducted in solutions containing sodium hydroxide (NaOH), potassium hydroxide (KOH) and calcium hydroxide (Ca(OH)(2)), with limited study of the effect of sulfates (SO42-). These sulfates are known to be present in the pore solution of materials like Portland cement-based concrete and may also ingress by the exposure to sulfate-rich environments. This study investigates the passivation behaviour and potentiodynamic polarisation behaviour of a high-strength carbon steel and high-strength stainless steels (austenitic and duplex) in saturated calcium hydroxide solutions containing up to 2000 ppm SO42-. Results indicate a negligible impact on the passivation behaviours of single-phase carbon steel and austenitic stainless steels. However, in duplex stainless steels, 1000 ppm of SO42- promotes passivation, whereas higher concentrations of 2000 ppm inhibit passivation. Additional research is necessary to correlate the altered passivation behaviour resulting from the presence of SO42- with chloride-induced corrosion resistance. C1 [Moser, Robert D.] US Army Engineer Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA. [Kurtis, Kimberly E.; Kahn, Lawrence F.] Georgia Inst Technol, Sch Civil & Environm Engn, Atlanta, GA 30332 USA. [Singh, Preet M.] Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA. RP Moser, RD (reprint author), US Army Engineer Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA. NR 17 TC 1 Z9 1 U1 1 U2 1 PU ICE PUBLISHING PI WESTMINISTER PA INST CIVIL ENGINEERS, 1 GREAT GEORGE ST, WESTMINISTER SW 1P 3AA, ENGLAND SN 1747-650X EI 1747-6518 J9 PROC INST CIV ENG-CO JI Proc. Inst. Civ. Eng.-Constr. Mater. PD FEB PY 2016 VL 169 IS 1 BP 39 EP 43 DI 10.1680/coma.14.00016 PG 5 WC Construction & Building Technology SC Construction & Building Technology GA DZ8GJ UT WOS:000386108600005 ER PT J AU Carter, R Hinojosa-Laborde, C Convertino, VA AF Carter, Robert, III Hinojosa-Laborde, Carmen Convertino, Victor A. TI Variability in integration of mechanisms associated with high tolerance to progressive reductions in central blood volume: the compensatory reserve SO PHYSIOLOGICAL REPORTS LA English DT Article DE Presyncope; hypovolemia; hemorrhage; compensatory reserve ID BODY NEGATIVE-PRESSURE; HEART-RATE-VARIABILITY; CENTRAL HYPOVOLEMIA; ARTERIAL-PRESSURE; BAROREFLEX; TRAUMA; EPIDEMIOLOGY; OSCILLATIONS; SENSITIVITY; INFARCTION AB High tolerance to progressive reductions in central blood volume has been associated with higher heart rate (HR), peripheral vascular resistance (PVR), sympathetic nerve activity (SNA), and vagally mediated cardiac baroreflex sensitivity (BRS). Using a database of 116 subjects classified as high tolerance to presyncopal-limited lower body negative pressure (LBNP), we tested the hypothesis that subjects with greater cardiac baroreflex withdrawal (i.e., BRS > 1.0) would demonstrate greater LBNP tolerance associated with higher HR, PVR, and SNA. Subjects underwent LBNP to presyncope. Mean and diastolic arterial pressure (MAP; DAP) was measured by finger photoplethysmography and BRS (down sequence) was autocalculated (WinCPRS) as Delta R-R Interval/Delta DAP. Down(BRS) (ms/mmHg) was used to dichotomize subjects into two groups (Group 1 = Down(BRS) > 1.0, N = 49, and Group 2 = Down(BRS) < 1.0, N = 67) at the time of presyncope. Muscle SNA was measured directly from the peroneal nerve via microneurography (N = 19) in subjects from Groups 1 (n = 9) and 2 (n = 10). Group 1 (Down(BRS) > 1.0) had lower HR (107 +/- 19 vs. 131 +/- 20 bpm), higher stroke volume (45 +/- 15 vs. 36 +/- 15 mL), less SNA (45 +/- 13 vs. 53 +/- 7 bursts/min), and less increase in PVR (4.1 +/- 1.3 vs. 4.5 +/- 2.6) compared to Group 2 (Down(BRS) < 1.0). Both groups had similar tolerance times (1849 +/- 260 vs. 1839 +/- 253 sec), MAP (78 +/- 11 vs. 79 +/- 12 mmHg), compensatory reserve index (CRI) (0.10 +/- 0.03 vs. 0.09 +/- 0.01), and cardiac output (4.5 +/- 1.2 vs. 4.7 +/- 1.1 L/min) at presyncope. Contrary to our hypothesis, higher HR, PVR, SNA, and BRS were not associated with greater tolerance to reduced central blood volume. These data are the first to demonstrate the variability and uniqueness of individual human physiological strategies designed to compensate for progressive reductions in central blood volume. The sum total of these integrated strategies is accurately reflected by the measurement of the compensatory reserve. C1 [Carter, Robert, III; Hinojosa-Laborde, Carmen; Convertino, Victor A.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Carter, R (reprint author), US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. EM robert.carter422.mil@mail.mil NR 27 TC 2 Z9 2 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2051-817X J9 PHYSIOL REP JI PHYSIOL. REP. PD FEB PY 2016 VL 4 IS 4 AR e12705 DI 10.14814/phy2.12705 PG 7 WC Physiology SC Physiology GA DR9SU UT WOS:000380237200004 ER PT J AU Cooper, SA Desjardins, PJ Turk, DC Dworkin, RH Katz, NP Kehlet, H Ballantyne, JC Burke, LB Carragee, E Cowan, P Croll, S Dionne, RA Farrar, JT Gilron, I Gordon, DB Iyengar, S Jay, GW Kalso, EA Kerns, RD McDermott, MP Raja, SN Rappaport, BA Rauschkolb, C Royal, MA Segerdahl, M Stauffer, JW Todd, KH Vanhove, GF Wallace, MS West, C White, RE Wu, C AF Cooper, Stephen A. Desjardins, Paul J. Turk, Dennis C. Dworkin, Robert H. Katz, Nathaniel P. Kehlet, Henrik Ballantyne, Jane C. Burke, Laurie B. Carragee, Eugene Cowan, Penney Croll, Scott Dionne, Raymond A. Farrar, John T. Gilron, Ian Gordon, Debra B. Iyengar, Smriti Jay, Gary W. Kalso, Eija A. Kerns, Robert D. McDermott, Michael P. Raja, Srinivasa N. Rappaport, Bob A. Rauschkolb, Christine Royal, Mike A. Segerdahl, Marta Stauffer, Joseph W. Todd, Knox H. Vanhove, Geertrui F. Wallace, Mark S. West, Christine White, Richard E. Wu, Christopher TI Research design considerations for single-dose analgesic clinical trials in acute pain: IMMPACT recommendations SO PAIN LA English DT Review DE Randomized clinical trials; Acute pain; Research design; Assay sensitivity; Proof-of-concept trials; Clinical trial methods ID POSTOPERATIVE DENTAL PAIN; INDIVIDUAL PATIENT METAANALYSIS; PLACEBO-CONTROLLED TRIALS; ACTIVE-CONTROL TRIALS; MOVEMENT-EVOKED PAIN; DOUBLE-BLIND; RATING-SCALES; PARECOXIB SODIUM; MISSING DATA; EFFICACY AB This article summarizes the results of a meeting convened by the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) on key considerations and best practices governing the design of acute pain clinical trials. We discuss the role of early phase clinical trials, including pharmacokinetic-pharmacodynamic (PK-PD) trials, and the value of including both placebo and active standards of comparison in acute pain trials. This article focuses on single-dose and short-duration trials with emphasis on the perioperative and study design factors that influence assay sensitivity. Recommendations are presented on assessment measures, study designs, and operational factors. Although most of the methodological advances have come from studies of postoperative pain after dental impaction, bunionectomy, and other surgeries, the design considerations discussed are applicable to many other acute pain studies conducted in different settings. C1 [Cooper, Stephen A.] Stephen A Cooper LLC, Palm Beach Gardens, FL USA. [Desjardins, Paul J.] Tufts Univ, Desjardins Associates LLC, Boston, MA 02111 USA. [Desjardins, Paul J.] Tufts Univ, Dept Oral & Maxillofacial Surg, Boston, MA 02111 USA. [Turk, Dennis C.; Ballantyne, Jane C.] Univ Washington, Dept Anesthesiol & Pain Med, Seattle, WA 98195 USA. [Dworkin, Robert H.; McDermott, Michael P.] Univ Rochester, Dept Anesthesiol, Rochester, NY USA. [Dworkin, Robert H.; McDermott, Michael P.] Univ Rochester, Dept Neurol, Rochester, NY USA. [Dworkin, Robert H.; McDermott, Michael P.] Univ Rochester, Dept Biostat & Computat Biol, Rochester, NY USA. [Katz, Nathaniel P.] Analges Solut, Needham, MA USA. [Kehlet, Henrik] Rigshosp, Sect Surg Pathophysiol, Copenhagen, Denmark. [Burke, Laurie B.] Univ Maryland, Dept Hlth Serv Res, Baltimore, MD 21201 USA. [Burke, Laurie B.] LORA Grp LLC, Royal Oak, MD USA. [Carragee, Eugene] Stanford Univ, Dept Orthoped Surg, Palo Alto, CA 94304 USA. [Cowan, Penney] Amer Chron Pain Assoc, Rocklin, CA USA. [Croll, Scott] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Dionne, Raymond A.] E Carolina Univ, Dept Pharmacol, Greenville, NC USA. [Dionne, Raymond A.] E Carolina Univ, Dept Toxicol, Greenville, NC USA. [Dionne, Raymond A.] E Carolina Univ, Dept Foundat Sci, Greenville, NC USA. [Farrar, John T.] Univ Penn, Dept Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA. [Gilron, Ian] Queens Univ, Dept Anesthesiol, Kingston, ON, Canada. [Gordon, Debra B.] Univ Washington, Dept Anesthesiol & Pain Med, Seattle, WA USA. [Iyengar, Smriti] Eli Lilly & Co, Indianapolis, IN 46285 USA. [Jay, Gary W.] Advise Clin, Raleigh, NC USA. [Kalso, Eija A.] Univ Helsinki, Dept Anaesthesia Intens Care & Pain Med, Helsinki, Finland. [Kalso, Eija A.] Helsinki Univ Hosp, Helsinki, Finland. [Kerns, Robert D.] US Dept Vet Affairs, New Haven, CT USA. [Raja, Srinivasa N.; Wu, Christopher] Johns Hopkins Univ, Dept Anesthesiol & Crit Care Med, Baltimore, MD USA. [Rappaport, Bob A.] Analges Concepts LLC, Arlington, VA USA. [Rauschkolb, Christine] Johnson & Johnson Pharmaceut Res & Dev, Titusville, NY USA. [Royal, Mike A.] Sorrento Therapeut, San Diego, CA USA. [Segerdahl, Marta] Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden. [Stauffer, Joseph W.] Johns Hopkins Univ, Baltimore, MD USA. [Stauffer, Joseph W.] Cara Therapeut, Shelton, CT USA. [Todd, Knox H.] Univ Texas MD Anderson Canc Ctr, Dept Emergency Med, Houston, TX 77030 USA. [Vanhove, Geertrui F.] NeurogesX, San Carlos, CA USA. [Wallace, Mark S.] Univ Calif San Diego, Dept Anesthesiol, San Diego, CA 92103 USA. [West, Christine] Pfizer Inc, Groton, CT 06340 USA. [White, Richard E.] Endo Pharmaceut, Chadds Ford, PA USA. RP Cooper, SA (reprint author), 40 Durand Rd, Maplewood, NJ 07040 USA. EM paul.j.desjardins@gmail.com FU Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION); FDA; US Department of Veteran Affairs; US National Institutes of Health FX Preparation of the background literature reviews and draft manuscripts was supported by the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION); public-private partnership with the US Food and Drug Administration (FDA) ACTTION has received research contracts, grants, and other revenue from the FDA, multiple pharmaceutical and device companies, and other sources. No official endorsement by the FDA, US Department of Veteran Affairs, US National Institutes of Health, or the pharmaceutical and medical devices companies that have provided unrestricted grants to support the activities of IMMPACT and ACTTION should be inferred. NR 74 TC 3 Z9 3 U1 1 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0304-3959 EI 1872-6623 J9 PAIN JI Pain PD FEB PY 2016 VL 157 IS 2 BP 288 EP 301 DI 10.1097/j.pain.0000000000000375 PG 14 WC Anesthesiology; Clinical Neurology; Neurosciences SC Anesthesiology; Neurosciences & Neurology GA DP1NV UT WOS:000378257600004 PM 26683233 ER PT J AU Tartaglia, LJ Chang, HW Lee, BC Abbink, P Ng'ang'a, D Boyd, M Lavine, CL Lim, SY Sanisetty, S Whitney, JB Seaman, MS Rolland, M Tovanabutra, S Ananworanich, J Robb, ML Kim, JH Michael, NL Barouch, DH AF Tartaglia, Lawrence J. Chang, Hui-Wen Lee, Benjamin C. Abbink, Peter Ng'ang'a, David Boyd, Michael Lavine, Christy L. Lim, So-Yon Sanisetty, Srisowmya Whitney, James B. Seaman, Michael S. Rolland, Morgane Tovanabutra, Sodsai Ananworanich, Jintanat Robb, Merlin L. Kim, Jerome H. Michael, Nelson L. Barouch, Dan H. TI Production of Mucosally Transmissible SHIV Challenge Stocks from HIV-1 Circulating Recombinant Form 01_AE env Sequences SO PLOS PATHOGENS LA English DT Article ID VACCINE EFFICACY TRIAL; RHESUS-MONKEYS; VIRUS; NEUTRALIZATION; INDUCTION; INFECTION; ASSAY; TIME AB Simian-human immunodeficiency virus (SHIV) challenge stocks are critical for preclinical testing of vaccines, antibodies, and other interventions aimed to prevent HIV-1. A major unmet need for the field has been the lack of a SHIV challenge stock expressing circulating recombinant form 01_AE (CRF01_AE) env sequences. We therefore sought to develop mucosally transmissible SHIV challenge stocks containing HIV-1 CRF01_AE env derived from acutely HIV-1 infected individuals from Thailand. SHIV-AE6, SHIV-AE6RM, and SHIV-AE16 contained env sequences that were >99% identical to the original HIV-1 isolate and did not require in vivo passaging. These viruses exhibited CCR5 tropism and displayed a tier 2 neutralization phenotype. These challenge stocks efficiently infected rhesus monkeys by the intrarectal route, replicated to high levels during acute infection, and established chronic viremia in a subset of animals. SHIV-AE16 was titrated for use in single, high dose as well as repetitive, low dose intrarectal challenge studies. These SHIV challenge stocks should facilitate the preclinical evaluation of vaccines, monoclonal antibodies, and other interventions targeted at preventing HIV-1 CRF01_AE infection. C1 [Tartaglia, Lawrence J.; Chang, Hui-Wen; Lee, Benjamin C.; Abbink, Peter; Ng'ang'a, David; Boyd, Michael; Lavine, Christy L.; Lim, So-Yon; Sanisetty, Srisowmya; Whitney, James B.; Seaman, Michael S.; Barouch, Dan H.] Beth Israel Deaconess Med Ctr, Ctr Virol & Vaccine Res, Boston, MA 02215 USA. [Whitney, James B.; Seaman, Michael S.; Barouch, Dan H.] Ragon Inst MGH MIT & Harvard, Cambridge, MA USA. [Rolland, Morgane; Tovanabutra, Sodsai; Ananworanich, Jintanat; Robb, Merlin L.; Kim, Jerome H.; Michael, Nelson L.] Walter Reed Army Inst Res, US Govt Mil HIV Res Program MHRP, Silver Spring, MD USA. [Kim, Jerome H.] Int Vaccine Inst, Seoul, South Korea. RP Barouch, DH (reprint author), Beth Israel Deaconess Med Ctr, Ctr Virol & Vaccine Res, Boston, MA 02215 USA.; Barouch, DH (reprint author), Ragon Inst MGH MIT & Harvard, Cambridge, MA USA. EM dbarouch@bidmc.harvard.edu RI Chang, Hui-Wen/C-9058-2017 OI Chang, Hui-Wen/0000-0001-8877-1886 FU Henry M. Jackson Foundation for the Advancement of Military Medicine [W81XWH-11-2-0174]; U.S. Army Medical Research and Materiel Command [W81XWH-11-2-0174]; National Institute of Allergy and Infectious Diseases [AI096040, AI095985, AI078526] FX This work was supported by a cooperative agreement (W81XWH-11-2-0174) between the Henry M. Jackson Foundation for the Advancement of Military Medicine and the U.S. Army Medical Research and Materiel Command. This research was funded, in part, by the National Institute of Allergy and Infectious Diseases (AI096040, AI095985, AI078526). The views expressed are those of the authors and should not be construed to represent the positions of the Department of the Army, Department of Defense, or the National Institute of Allergy and Infectious Diseases. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 22 TC 4 Z9 4 U1 0 U2 0 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1553-7366 EI 1553-7374 J9 PLOS PATHOG JI PLoS Pathog. PD FEB PY 2016 VL 12 IS 2 AR e1005431 DI 10.1371/journal.ppat.1005431 PG 16 WC Microbiology; Parasitology; Virology SC Microbiology; Parasitology; Virology GA DP0BP UT WOS:000378152900027 PM 26849216 ER PT J AU Kim, PY Toblin, RL Riviere, LA Kok, BC Grossman, SH Wilk, JE AF Kim, Paul Y. Toblin, Robin L. Riviere, Lyndon A. Kok, Brian C. Grossman, Sasha H. Wilk, Joshua E. TI Provider and Nonprovider Sources of Mental Health Help in the Military and the Effects of Stigma, Negative Attitudes, and Organizational Barriers to Care SO PSYCHIATRIC SERVICES LA English DT Article ID NATIONAL-GUARD SOLDIERS; COMBAT; DEPRESSION; SERVICES; CLERGY; PTSD; VETERANS; DISORDER; SEEKING; SUPPORT AB Objective: This study examined sources of help (providers or nonproviders) used by soldiers for mental health problems. Differences in perceived barriers to care by type of help used were also assessed. Methods: Active-duty soldiers from four brigade combat teams (N=3,380) were surveyed in 2008-2009. Items assessed posttraumatic stress disorder; depression; anxiety; help needed because of a stress, emotional, alcohol, or family problem; stigma; negative attitudes toward care; and organizational barriers. Participants reported receipt of help in the past three months from providers (mental health or medical professionals or an Army resource hotline) or nonproviders (fellow soldier, medic, chaplain, or chain of command). Results: Nearly a third (31%) were identified as being in need of mental health care. Of those, 5% reported using nonprovider help exclusively, 14% used provider help exclusively, and 7% used both types. Stigma was rated significantly lower as a barrier among those who used help exclusively from providers than among those who did not use help from any source; however, no significant differences in stigma scores were found between those who used help from nonproviders and those who did not use help from any source. Soldiers who used help from nonproviders were more likely than those who used help from providers to perceive organizational barriers. Conclusions: Results show that soldiers may view nonproviders as alternative sources of mental health help, suggesting that the Army should ensure that such resources are adequately trained and integrated into the mental health community so that soldiers can receive the help they need. C1 [Kim, Paul Y.; Riviere, Lyndon A.; Kok, Brian C.; Grossman, Sasha H.; Wilk, Joshua E.] US Army, Walter Reed Army Inst Res, Silver Spring, MD USA. [Toblin, Robin L.] US Army, Walter Reed Army Inst Res, Res Transit Branch, Silver Spring, MD USA. RP Kim, PY (reprint author), US Army, Walter Reed Army Inst Res, Silver Spring, MD USA. EM paul.y.kim12.ctr@mail.mil FU Military Operational Medicine Research Program, U.S. Army Medical Research and Materiel Command FX This study was supported by the Military Operational Medicine Research Program, U.S. Army Medical Research and Materiel Command and by core funding. The authors thank the Land Combat Study team for their support with the data collection. Material was reviewed by the Walter Reed Army Institute of Research; no objection was made to the presentation or publication of these findings. The opinions or assertions are the personal views of the authors and are not to be construed as official or as reflecting the views of the U.S. Department of the Army or the U.S. Department of Defense. NR 27 TC 0 Z9 0 U1 2 U2 2 PU AMER PSYCHIATRIC PUBLISHING, INC PI ARLINGTON PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA SN 1075-2730 EI 1557-9700 J9 PSYCHIAT SERV JI Psychiatr. Serv. PD FEB PY 2016 VL 67 IS 2 BP 221 EP 226 DI 10.1176/appi.ps.201400519 PG 6 WC Health Policy & Services; Public, Environmental & Occupational Health; Psychiatry SC Health Care Sciences & Services; Public, Environmental & Occupational Health; Psychiatry GA DO4SZ UT WOS:000377775400018 PM 26423099 ER PT J AU Tasissa, AF Hautefeuille, M Fitek, JH Radovitzky, RA AF Tasissa, Abiy F. Hautefeuille, Martin Fitek, John H. Radovitzky, Raul A. TI On the formation of Friedlander waves in a compressed-gas-driven shock tube SO PROCEEDINGS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES LA English DT Article DE blast waves; shock tubes; Friedlander waves ID TRAUMATIC BRAIN-INJURY; BLAST; MODELS AB Compressed-gas-driven shock tubes have become popular as a laboratory-scale replacement for field blast tests. The well-known initial structure of the Riemann problem eventually evolves into a shock structure thought to resemble a Friedlander wave, although this remains to be demonstrated theoretically. In this paper, we develop a semi-analytical model to predict the key characteristics of pseudo blast waves forming in a shock tube: location where the wave first forms, peak over-pressure, decay time and impulse. The approach is based on combining the solutions of the two different types of wave interactions that arise in the shock tube after the family of rarefaction waves in the Riemann solution interacts with the closed end of the tube. The results of the analytical model are verified against numerical simulations obtained with a finite volume method. The model furnishes a rational approach to relate shock tube parameters to desired blast wave characteristics, and thus constitutes a useful tool for the design of shock tubes for blast testing. C1 [Tasissa, Abiy F.; Hautefeuille, Martin; Radovitzky, Raul A.] MIT, Dept Aeronaut & Astronaut, Inst Solider Nanotechnol, Cambridge, MA 02139 USA. [Fitek, John H.] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA. RP Radovitzky, RA (reprint author), MIT, Dept Aeronaut & Astronaut, Inst Solider Nanotechnol, Cambridge, MA 02139 USA. EM rapa@mit.edu FU US Army Research Laboratory; US Army Research Office through Institute for Soldier Nanotechnologies [W911NF-13-D-0001] FX This work was supported by the US Army Research Laboratory and the US Army Research Office through the Institute for Soldier Nanotechnologies, under contract no. W911NF-13-D-0001. NR 27 TC 0 Z9 0 U1 4 U2 4 PU ROYAL SOC PI LONDON PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND SN 1364-5021 EI 1471-2946 J9 P ROY SOC A-MATH PHY JI Proc. R. Soc. A-Math. Phys. Eng. Sci. PD FEB 1 PY 2016 VL 472 IS 2186 AR 20150611 DI 10.1098/rspa.2015.0611 PG 24 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DO3ZC UT WOS:000377720300008 PM 27118888 ER PT J AU Kirwin, P Conroy, M Lyketsos, C Greenwald, B Forester, B deVries, C Ahmed, II Wiechers, I Zdanys, K Steffens, D Reynolds, CF AF Kirwin, Paul Conroy, Michelle Lyketsos, Constantine Greenwald, Blaine Forester, Brent deVries, Christine Ahmed, Iqbal Ike Wiechers, Ilse Zdanys, Kristina Steffens, David Reynolds, Charles F., II TI A Call to Restructure Psychiatry General and Subspecialty Training SO ACADEMIC PSYCHIATRY LA English DT Article DE Residency education; Fellowship training; Subspecialty training; ACGME; ABPN AB Dire shortages of psychiatrists with special expertise in geriatrics, substance abuse, forensics, and psychosomatics create barriers to care for populations with complex mental disorders and pose a significant public health concern. To address these disparities in access to care, we propose streamlining graduate medical education to increase efficiency and enhance cost-effectiveness while simultaneously increasing the number ofpsychiatric subspecialists in these key areas. We propose that trainees interested in subspecialties complete their general training in 3 years, while meeting ACGME required milestones, and then utilize their 4th year to complete subspecialty fellowship training. Eligible trainees would then qualify' for psychiatry subspecialty certification and general psychiatry ABPN certification at the end of 4 years. C1 [Kirwin, Paul; Conroy, Michelle; Wiechers, Ilse] Yale Univ, Sch Med, VA Connecticut Healthcare Syst, West Haven, CT 06516 USA. [Lyketsos, Constantine] Johns Hopkins Univ Hosp, Baltimore, MD 21287 USA. [Greenwald, Blaine] N Shore Univ Hosp, Long Isl Jewish Med Ctr, Glen Oaks, NY USA. [Forester, Brent] Harvard Univ, McLean Hosp, Sch Med, Belmont, MA USA. [deVries, Christine] Amer Assoc Geriatr Psychiat, Bethesda, MD USA. [Ahmed, Iqbal Ike] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Zdanys, Kristina] Univ Connecticut, Ctr Hlth, Farmington, CT USA. [Steffens, David] Univ Connecticut, Sch Med, Farmington, CT USA. [Reynolds, Charles F., II] Univ Pittsburgh, Med Ctr, Pittsburgh, PA USA. RP Kirwin, P (reprint author), Yale Univ, Sch Med, VA Connecticut Healthcare Syst, West Haven, CT 06516 USA. EM Paul.Kirwin@yale.edu NR 11 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1042-9670 EI 1545-7230 J9 ACAD PSYCHIATR JI Acad. Psych. PD FEB PY 2016 VL 40 IS 1 BP 145 EP 148 DI 10.1007/s40596-014-0144-5 PG 4 WC Education & Educational Research; Psychiatry SC Education & Educational Research; Psychiatry GA DN5HL UT WOS:000377097100027 PM 24809688 ER PT J AU Lemasson, BH Tanner, CJ Dimperio, E AF Lemasson, Bertrand H. Tanner, Colby J. Dimperio, Eric TI A Sensory-Driven Trade-Off between Coordinated Motion in Social Prey and a Predator's Visual Confusion SO PLOS COMPUTATIONAL BIOLOGY LA English DT Article ID INFORMATION-TRANSFER; EYE-MOVEMENTS; FISH; BEHAVIOR; PURSUIT; PERCEPTION; SMOOTH; HUMANS; BACKGROUNDS; REGRESSION AB Social animals are capable of enhancing their awareness by paying attention to their neighbors, and prey found in groups can also confuse their predators. Both sides of these sensory benefits have long been appreciated, yet less is known of how the perception of events from the perspectives of both prey and predator can interact to influence their encounters. Here we examined how a visual sensory mechanism impacts the collective motion of prey and, subsequently, how their resulting movements influenced predator confusion and capture ability. We presented virtual prey to human players in a targeting game and measured the speed and accuracy with which participants caught designated prey. As prey paid more attention to neighbor movements their collective coordination increased, yet increases in prey coordination were positively associated with increases in the speed and accuracy of attacks. However, while attack speed was unaffected by the initial state of the prey, accuracy dropped significantly if the prey were already organized at the start of the attack, rather than in the process of self-organizing. By repeating attack scenarios and masking the targeted prey's neighbors we were able to visually isolate them and conclusively demonstrate how visual confusion impacted capture ability. Delays in capture caused by decreased coordination amongst the prey depended upon the collection motion of neighboring prey, while it was primarily the motion of the targets themselves that determined capture accuracy. Interestingly, while a complete loss of coordination in the prey (e.g., a flash expansion) caused the greatest delay in capture, such behavior had little effect on capture accuracy. Lastly, while increases in collective coordination in prey enhanced personal risk, traveling in coordinated groups was still better than appearing alone. These findings demonstrate a trade-off between the sensory mechanisms that can enhance the collective properties that emerge in social animals and the individual group member's predation risk during an attack. C1 [Lemasson, Bertrand H.; Dimperio, Eric] US Army, ERDC, Environm Lab, Santa Barbara, CA USA. [Tanner, Colby J.] Univ Lausanne, Dept Ecol, CH-1015 Lausanne, Switzerland. [Lemasson, Bertrand H.] Environm Lab ERDC, Newport, OR USA. [Tanner, Colby J.] Univ Nebraska, Sch Biol Sci, Lincoln, NE USA. [Dimperio, Eric] Corios LLC, Portland, OR USA. RP Lemasson, BH (reprint author), US Army, ERDC, Environm Lab, Santa Barbara, CA USA.; Lemasson, BH (reprint author), Environm Lab ERDC, Newport, OR USA. EM brilraven@gmail.com FU ERDC's Environmental Laboratory's EQ/I Basic Research Program [BT25-NS/12-64]; Marie Curie Fellowship FX BHL and ED were supported by ERDC's Environmental Laboratory's EQ/I Basic Research Program, Grant #: BT25-NS/12-64 (http://www.erdc.usace.army.mil/Locations/Environmenta vertical bar Laboratory.aspx) CJT was supported by a Marie Curie Fellowship (http://research.ie/scheme/inspire-postdoctoral-fellowship-scheme). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 59 TC 0 Z9 0 U1 0 U2 0 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1553-734X EI 1553-7358 J9 PLOS COMPUT BIOL JI PLoS Comput. Biol. PD FEB PY 2016 VL 12 IS 2 AR e1004708 DI 10.1371/journal.pcbi.1004708 PG 20 WC Biochemical Research Methods; Mathematical & Computational Biology SC Biochemistry & Molecular Biology; Mathematical & Computational Biology GA DM8AL UT WOS:000376582900013 PM 26914768 ER PT J AU Kaini, RR Shen-Gunther, J Cleland, JM Greene, WA Wang, HC AF Kaini, Ramesh R. Shen-Gunther, Jane Cleland, Jeffery M. Greene, Whitney A. Wang, Heuy-Ching TI Recombinant Xeno-Free Vitronectin Supports Self-Renewal and Pluripotency in Protein-Induced Pluripotent Stem Cells SO TISSUE ENGINEERING PART C-METHODS LA English DT Article ID EXTRACELLULAR-MATRIX; SOMATIC-CELLS; FREE CULTURE; GENERATION; LINES; DERIVATION; EXPANSION; THERAPY; FATE AB Patient safety is a major concern in the application of induced pluripotent stem cells (iPSCs) in cell-based therapy. Efforts are being made to reprogram, maintain, and differentiate iPSCs in defined conditions to provide a safe source of stem cells for regenerative medicine. Recently, human fibroblasts were successfully reprogrammed into pluripotent stem cells using four recombinant proteins (OCT4, c-Myc, KLF4, and SOX2) fused with a cell-penetrating peptide (9R). These protein-induced pluripotent stem cells (piPSCs) are maintained and propagated on a feeder layer of mouse embryonic fibroblasts. Use of animal-derived products in maintenance and differentiation of iPSCs poses risks of zoonotic disease transmission and immune rejection when transplanted into humans. To avoid potential incorporation of xenogenic products, we cultured piPSCs on recombinant human matrix proteins. We then tested whether recombinant human matrix proteins can support self-renewal and pluripotency of piPSCs. After long-term culture on recombinant human vitronectin in xeno-free conditions, piPSCs retained the expression of pluripotent markers. The pluripotency of these cells was further evaluated by differentiating toward ectoderm, mesoderm, and endoderm lineages in vitro. In conclusion, recombinant human vitronectin can support the long-term culture and maintain the stemness of piPSCs in defined nonxenogenic conditions. C1 [Kaini, Ramesh R.; Cleland, Jeffery M.; Greene, Whitney A.; Wang, Heuy-Ching] US Army, Inst Surg Res, Ocular Trauma Task Area, 3698 Chamber Pass,Bldg 3611, Jbsa Ft Sam Houston, TX 78234 USA. [Shen-Gunther, Jane] Brooke Army Med Ctr, Dept Clin Invest, Div Gynecol Oncol, 3698 Chamber Pass,Bldg 3611, Jbsa Ft Sam Houston, TX 78234 USA. RP Wang, HC (reprint author), US Army, Inst Surg Res, Ocular Trauma Task Area, 3698 Chamber Pass,Bldg 3611, Jbsa Ft Sam Houston, TX 78234 USA. EM heuy-ching.h.wang.civ@mail.mil FU U.S. Army Clinical Rehabilitative Medicine Research Program (CRMRP); Military Operational Medicine Research Program (MOMRP) FX We thank Mr. Dallas Golden for supporting tissue culture works and Mr. Luis Perez for confocal microscopy. This work was supported by U.S. Army Clinical Rehabilitative Medicine Research Program (CRMRP) and Military Operational Medicine Research Program (MOMRP) to H.-C.W. R.R.K. is a National Research Council Research Associate. NR 48 TC 1 Z9 1 U1 4 U2 4 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1937-3384 EI 1937-3392 J9 TISSUE ENG PART C-ME JI Tissue Eng. Part C-Methods PD FEB PY 2016 VL 22 IS 2 BP 85 EP 90 DI 10.1089/ten.tec.2015.0180 PG 6 WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell Biology SC Cell Biology; Biotechnology & Applied Microbiology GA DM4AP UT WOS:000376288200001 ER PT J AU Greene, AE McGeeney, RJ AF Greene, Amy Elise McGeeney, Robert J. TI Many shades of guilt SO CLEVELAND CLINIC JOURNAL OF MEDICINE LA English DT Editorial Material C1 [Greene, Amy Elise] Cleveland Clin, Spiritual Care, Q1-101,9500 Euclid Ave, Cleveland, OH 44195 USA. [McGeeney, Robert J.] Cleveland Clin, Clin Pastoral Educ, Cleveland, OH 44195 USA. [McGeeney, Robert J.] US Army Reserve, Ft Bragg, NC USA. RP Greene, AE (reprint author), Cleveland Clin, Spiritual Care, Q1-101,9500 Euclid Ave, Cleveland, OH 44195 USA. EM greenea3@ccf.org NR 4 TC 0 Z9 0 U1 0 U2 0 PU CLEVELAND CLINIC PI CLEVELAND PA 9500 EUCLID AVE, CLEVELAND, OH 44106 USA SN 0891-1150 EI 1939-2869 J9 CLEV CLIN J MED JI Clevel. Clin. J. Med. PD FEB PY 2016 VL 83 IS 2 BP 106 EP 108 DI 10.3949/ccjm.83a.15136 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA DK3TR UT WOS:000374840800007 PM 26871386 ER PT J AU Kosisky, SE Banks, TA Spriet, SW AF Kosisky, Susan E. Banks, Taylor A. Spriet, Sarah W. TI Daily Fluctuations in Airborne Ragweed Pollen Levels in Washington, DC (2007-2009) SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY LA English DT Meeting Abstract CT Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology (AAAAI) CY MAR 04-07, 2016 CL Los Angeles, CA SP Amer Acad Allergy, Asthma & Immunol C1 [Kosisky, Susan E.] US Army, Centralized Allergen Extract Lab, Burtonsville, MD USA. [Banks, Taylor A.; Spriet, Sarah W.] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0091-6749 EI 1097-6825 J9 J ALLERGY CLIN IMMUN JI J. Allergy Clin. Immunol. PD FEB PY 2016 VL 137 IS 2 SU S MA 396 BP AB121 EP AB121 PG 1 WC Allergy; Immunology SC Allergy; Immunology GA DK6BI UT WOS:000375005402086 ER PT J AU Schultz, NE Ahmad, R Brennan, JK Frankel, KA Moore, JD Moore, JD Mountain, RD Ross, RB Thommes, M Shen, VK Siderius, DW Smith, KD AF Schultz, Nathan E. Ahmad, Riaz Brennan, John K. Frankel, Kevin A. Moore, Jonathan D. Moore, Joshua D. Mountain, Raymond D. Ross, Richard B. Thommes, Matthias Shen, Vincent K. Siderius, Daniel W. Smith, Kenneth D. TI The Eighth Industrial Fluids Properties Simulation Challenge SO ADSORPTION SCIENCE & TECHNOLOGY LA English DT Article DE Molecular simulation; activated carbon; adsorption; perfluorohexane; organic compounds ID VAPOR-LIQUID-EQUILIBRIA; MOLECULAR-DYNAMICS SIMULATION; MONTE-CARLO SIMULATIONS; GLYCOL DIMETHYL ETHER; HENRYS LAW CONSTANTS; BUBBLE POINT PRESSURE; FORCE-FIELD; PREDICTING ADSORPTION; ETHYLENE-OXIDE; PERFLUOROHEXANE ADSORPTION AB The goal of the eighth industrial fluid properties simulation challenge was to test the ability of molecular simulation methods to predict the adsorption of organic adsorbates in activated carbon materials. In particular, the eighth challenge focused on the adsorption of perfluorohexane in the activated carbon BAM-P109. Entrants were challenged to predict the adsorption in the carbon at 273 K and relative pressures of 0.1, 0.3, and 0.6. The predictions were judged by comparison with a benchmark set of experimentally determined values. Overall, good agreement and consistency were found between the predictions of most entrants. C1 [Schultz, Nathan E.; Frankel, Kevin A.; Ross, Richard B.] 3M Co, Ctr 3M, 201-2E-23, St Paul, MN 55144 USA. [Ahmad, Riaz; Thommes, Matthias] Quantachrome Instruments, Boynton Beach, FL USA. [Brennan, John K.; Moore, Joshua D.] US Army, Res Lab, Aberdeen Proving Ground, MD USA. [Moore, Jonathan D.] Dow Chem Co USA, Midland, MI 48674 USA. [Mountain, Raymond D.; Shen, Vincent K.; Siderius, Daniel W.] NIST, Gaithersburg, MD 20899 USA. [Smith, Kenneth D.] United Technol Res Ctr, E Hartford, CT 06108 USA. RP Ross, RB (reprint author), 3M Co, Ctr 3M, 201-2E-23, St Paul, MN 55144 USA. EM rbross@mmm.com RI Moore, Jonathan/B-8201-2009 FU 3M Company; BP Amoco; Dow Chemical Company; DuPont; Exxon Mobil; Mitsubishi Chemical Corporation FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: We would like to thank the 3M Company, BP Amoco, The Dow Chemical Company, DuPont, Exxon Mobil, and Mitsubishi Chemical Corporation for their financial support. NR 64 TC 0 Z9 0 U1 1 U2 3 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0263-6174 EI 2048-4038 J9 ADSORPT SCI TECHNOL JI Adsorpt. Sci. Technol. PD FEB PY 2016 VL 34 IS 1 SI SI BP 3 EP 12 DI 10.1177/0263617415619521 PG 10 WC Chemistry, Applied; Chemistry, Physical; Engineering, Chemical SC Chemistry; Engineering GA DJ5ZL UT WOS:000374289400001 PM 27840542 ER PT J AU Ross, RB Aeschliman, DB Ahmad, R Brennan, JK Brostrom, ML Frankel, KA Moore, JD Moore, JD Mountain, RD Poirier, DM Thommes, M Shen, VK Schultz, NE Siderius, DW Smith, KD AF Ross, Richard B. Aeschliman, David B. Ahmad, Riaz Brennan, John K. Brostrom, Myles L. Frankel, Kevin A. Moore, Jonathan D. Moore, Joshua D. Mountain, Raymond D. Poirier, Derrick M. Thommes, Matthias Shen, Vincent K. Schultz, Nathan E. Siderius, Daniel W. Smith, Kenneth D. TI Adsorption, X-ray diffraction, photoelectron, and atomic emission spectroscopy benchmark studies for the eighth industrial fluid properties simulation challenge SO ADSORPTION SCIENCE & TECHNOLOGY LA English DT Article DE Perfluorohexane; adsorption; activated carbon; BAM-P109 activated carbon AB The primary goal of the eighth industrial fluid properties simulation challenge was to test the ability of molecular simulation methods to predict the adsorption of organic adsorbates in activated carbon materials. The challenge focused on the adsorption of perfluorohexane in the activated carbon standard BAM-P109. Entrants were challenged to predict the adsorption of perfluorohexane in the activated carbon at a temperature of 273K and at relative pressures of 0.1, 0.3, and 0.6. The relative pressure (P/P-o) is defined as that relative to the bulk saturation pressure predicted by the fluid model at a given temperature (273K in this case). The predictions were judged by comparison to a set of experimentally determined values, which are published here for the first time and were not disclosed to the entrants prior to the challenge. Benchmark experimental studies, described herein, were also carried out and provided to entrants in order to aid in the development of new force fields and simulation methods to be employed in the challenge. These studies included argon, carbon dioxide, and water adsorption in the BAM-P109 activated carbon as well as X-ray diffraction, X-ray microtomography, photoelectron spectroscopy, and atomic emission spectroscopy studies of BAM-P109. Several concurrent studies were carried out for the BAM-P108 activated carbon. These are included in the current manuscript for comparison. C1 [Ross, Richard B.; Aeschliman, David B.; Brostrom, Myles L.; Frankel, Kevin A.; Poirier, Derrick M.; Schultz, Nathan E.] 3M Co, St Paul, MN 55144 USA. [Ahmad, Riaz; Thommes, Matthias] Quantachrome Instruments, Boynton Beach, FL USA. [Brennan, John K.; Moore, Joshua D.] US Army, Weap & Mat Res Directorate, Res Lab, Aberdeen Proving Ground, MD USA. [Moore, Jonathan D.] Dow Chem Co USA, Midland, MI 48674 USA. [Mountain, Raymond D.; Shen, Vincent K.; Siderius, Daniel W.] NIST, Gaithersburg, MD 20899 USA. [Smith, Kenneth D.] United Technol Res Ctr, E Hartford, CT 06108 USA. RP Ross, RB (reprint author), 3M Co, St Paul, MN 55144 USA. EM rbross@mmm.com RI Moore, Jonathan/B-8201-2009 FU Intramural NIST DOC [9999-NIST] NR 15 TC 3 Z9 3 U1 3 U2 6 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0263-6174 EI 2048-4038 J9 ADSORPT SCI TECHNOL JI Adsorpt. Sci. Technol. PD FEB PY 2016 VL 34 IS 1 SI SI BP 13 EP 41 DI 10.1177/0263617415619541 PG 29 WC Chemistry, Applied; Chemistry, Physical; Engineering, Chemical SC Chemistry; Engineering GA DJ5ZL UT WOS:000374289400002 PM 27840543 ER PT J AU Kube, CM Turner, JA AF Kube, Christopher M. Turner, Joseph A. TI Stress-dependent ultrasonic scattering in polycrystalline materials SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID RESIDUAL-STRESSES; WAVE PROPAGATION; ACOUSTOELASTICITY; BACKSCATTER; ALUMINUM; TEXTURE; MICROSTRUCTURE; DEFORMATION; ATTENUATION; CRYSTALS AB Stress-dependent elastic moduli of polycrystalline materials are used in a statistically based model for the scattering of ultrasonic waves from randomly oriented grains that are members of a stressed polycrystal. The stress is assumed to be homogeneous and can be either residual or generated from external loads. The stress-dependent elastic properties are incorporated into the definition of the differential scattering cross-section, which defines how strongly an incident wave is scattered into various directions. Nine stress-dependent differential scattering cross-sections or scattering coefficients are defined to include all possibilities of incident and scattered waves, which can be either longitudinal or (two) transverse wave types. The evaluation of the scattering coefficients considers polycrystalline aluminum that is uniaxially stressed. An analysis of the influence of incident wave propagation direction, scattering direction, frequency, and grain size on the stress-dependency of the scattering coefficients follows. Scattering coefficients for aluminum indicate that ultrasonic scattering is much more sensitive to a uniaxial stress than ultrasonic phase velocities. By developing the stress-dependent scattering properties of polycrystals, the influence of acoustoelasticity on the amplitudes of waves propagating in stressed polycrystalline materials can be better understood. This work supports the ongoing development of a technique for monitoring and measuring stresses in metallic materials. (C) 2016 Acoustical Society of America. C1 [Kube, Christopher M.; Turner, Joseph A.] Univ Nebraska, Dept Mech & Mat Engn, W342 Nebraska Hall, Lincoln, NE 68588 USA. [Kube, Christopher M.] Army Res Lab, Mech Div, Vehicle Technol Directorate, 4603 Flare Loop, Aberdeen Proving Ground, MD 21005 USA. RP Kube, CM (reprint author), Univ Nebraska, Dept Mech & Mat Engn, W342 Nebraska Hall, Lincoln, NE 68588 USA.; Kube, CM (reprint author), Army Res Lab, Mech Div, Vehicle Technol Directorate, 4603 Flare Loop, Aberdeen Proving Ground, MD 21005 USA. EM ckube@huskers.unl.edu RI Turner, Joseph/F-5165-2010 NR 47 TC 0 Z9 0 U1 3 U2 7 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 EI 1520-8524 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD FEB PY 2016 VL 139 IS 2 BP 811 EP 824 DI 10.1121/1.4941253 PG 14 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA DI7TQ UT WOS:000373705300028 PM 26936563 ER PT J AU Dent, AE Malhotra, I Wang, XL Babineau, D Yeo, KT Anderson, T Kimmel, RJ Angov, E Lanar, DE Narum, D Dutta, S Richards, J Beeson, JG Crabb, BS Cowman, AF Horii, T Muchiri, E Mungai, PL King, CL Kazura, JW AF Dent, Arlene E. Malhotra, Indu Wang, Xuelie Babineau, Denise Yeo, Kee Thai Anderson, Timothy Kimmel, Rhonda J. Angov, Evelina Lanar, David E. Narum, David Dutta, Sheetij Richards, Jack Beeson, James G. Crabb, Brendan S. Cowman, Alan F. Horii, Toshihiro Muchiri, Eric Mungai, Peter L. King, Christopher L. Kazura, James W. TI Contrasting Patterns of Serologic and Functional Antibody Dynamics to Plasmodium falciparum Antigens in a Kenyan Birth Cohort SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID MEROZOITE SURFACE PROTEIN-1; APICAL MEMBRANE ANTIGEN-1; INVASION-INHIBITORY ANTIBODIES; IN-VITRO GROWTH; ERYTHROCYTE-BINDING ANTIGENS; NATURALLY ACQUIRED-IMMUNITY; INFECTED ERYTHROCYTES; MALARIA VACCINE; ESCHERICHIA-COLI; AOTUS-NANCYMAI AB IgG antibodies to Plasmodium falciparum are transferred from the maternal to fetal circulation during pregnancy, wane after birth, and are subsequently acquired in response to natural infection. We examined the dynamics of malaria antibody responses of 84 Kenyan infants from birth to 36 months of age by (i) serology, (ii) variant surface antigen (VSA) assay, (iii) growth inhibitory activity (GIA), and (iv) invasion inhibition assays (IIA) specific for merozoite surface protein 1 (MSP1) and sialic acid-dependent invasion pathway. Maternal antibodies in each of these four categories were detected in cord blood and decreased to their lowest level by approximately 6 months of age. Serologic antibodies to 3 preerythrocytic and 10 blood-stage antigens subsequently increased, reaching peak prevalence by 36 months. In contrast, antibodies measured by VSA, GIA, and IIA remained low even up to 36 months. Infants sensitized to P. falciparum in utero, defined by cord blood lymphocyte recall responses to malaria antigens, acquired antimalarial antibodies at the same rate as those who were not sensitized in utero, indicating that fetal exposure to malaria antigens did not affect subsequent infant antimalarial responses. Infants with detectable serologic antibodies at 12 months of age had an increased risk of P. falciparum infection during the subsequent 24 months. We conclude that serologic measures of antimalarial antibodies in children 36 months of age or younger represent biomarkers of malaria exposure rather than protection and that functional antibodies develop after 36 months of age in this population. C1 [Dent, Arlene E.; Malhotra, Indu; Kimmel, Rhonda J.; Mungai, Peter L.; King, Christopher L.; Kazura, James W.] Case Western Reserve Univ, Ctr Global Hlth & Dis, Cleveland, OH 44106 USA. [Dent, Arlene E.; Yeo, Kee Thai] Rainbow Babies & Childrens Hosp, Dept Pediat, Cleveland, OH 44106 USA. [Wang, Xuelie; Babineau, Denise] Case Western Reserve Univ, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA. [Anderson, Timothy] Case Western Reserve Univ, Sch Med, Cleveland, OH USA. [Angov, Evelina; Lanar, David E.; Dutta, Sheetij] Walter Reed Army Inst Res, Malaria Vaccine Branch, Silver Spring, MD USA. [Narum, David] NIAID, Lab Malaria Immunol & Vaccinol, NIH, Rockville, MD USA. [Richards, Jack; Beeson, James G.; Crabb, Brendan S.] Burnet Inst, Melbourne, Vic, Australia. [Beeson, James G.] Monash Univ, Dept Microbiol, Melbourne, Vic 3004, Australia. [Cowman, Alan F.] Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia. [Horii, Toshihiro] Osaka Univ, Microbial Dis Res Inst, Dept Mol Protozool, Suita, Osaka 565, Japan. [Muchiri, Eric; Mungai, Peter L.] Minist Publ Hlth & Sanitat, Div Vector Borne & Neglected Trop Dis, Nairobi, Kenya. [Babineau, Denise] Rho Fed Syst Div, Chapel Hill, NC USA. [Anderson, Timothy] Univ Pittsburgh, Med Ctr, Dept Med, Pittsburgh, PA USA. RP Dent, AE (reprint author), Case Western Reserve Univ, Ctr Global Hlth & Dis, Cleveland, OH 44106 USA.; Dent, AE (reprint author), Rainbow Babies & Childrens Hosp, Dept Pediat, Cleveland, OH 44106 USA. EM arlene.dent@case.edu FU HHS \ NIH \ National Institute of Allergy and Infectious Diseases (NIAID) [AI098511, AI064667, AI09519] FX HHS vertical bar NIH vertical bar National Institute of Allergy and Infectious Diseases (NIAID) provided funding to Arlene E. Dent under grant number AI098511. HHS vertical bar NIH vertical bar National Institute of Allergy and Infectious Diseases (NIAID) provided funding to Christopher L. King under grant number AI064667. HHS vertical bar NIH vertical bar National Institute of Allergy and Infectious Diseases (NIAID) provided funding to James W. Kazura under grant number AI09519. NR 92 TC 2 Z9 2 U1 3 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 EI 1556-679X J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD FEB PY 2016 VL 23 IS 2 BP 104 EP 116 DI 10.1128/CVI.00452-15 PG 13 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA DI4SI UT WOS:000373489200004 PM 26656119 ER PT J AU Chiles, DP Roberts, TA Klein, DA AF Chiles, Daniel P. Roberts, Timothy A. Klein, David A. TI LONG-ACTING REVERSIBLE CONTRACEPTION UPTAKE AND CONTINUATION IN A UNIVERSAL HEALTHCARE SYSTEM SO JOURNAL OF ADOLESCENT HEALTH LA English DT Meeting Abstract C1 [Chiles, Daniel P.] US Army, Washington, DC USA. [Roberts, Timothy A.; Klein, David A.] US Air Force, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1054-139X EI 1879-1972 J9 J ADOLESCENT HEALTH JI J. Adolesc. Health PD FEB PY 2016 VL 58 IS 2 SU S MA 152 BP S79 EP S80 PG 3 WC Psychology, Developmental; Public, Environmental & Occupational Health; Pediatrics SC Psychology; Public, Environmental & Occupational Health; Pediatrics GA DI3VW UT WOS:000373428800153 ER PT J AU Fielitz, L Coelho, J Horne, T Brechue, W AF Fielitz, Lynn Coelho, Jeffrey Horne, Thomas Brechue, William TI Inter-Rater Reliability and Intra-Rater Reliability of Assessing the 2-Minute Push-Up Test SO MILITARY MEDICINE LA English DT Article ID EXERCISE; VALIDITY AB The purpose of this study was to assess inter-rater reliability and intra-rater reliability of the 2-minute, 90 degrees push-up test as utilized in the Army Physical Fitness Test. Analysis of rater assessment reliability included both total score agreement and agreement across individual push-up repetitions. This study utilized 8 Raters who assessed 15 different videotaped push-up performances over 4 iterations separated by a minimum of 1 week. The 15 push-up participants were videotaped during the semiannual Army Physical Fitness Test. Each Rater randomly viewed the 15 push-up and verbally responded with a "yes" or "no" to each push-up repetition. The data generated were analyzed using the Pearson product-moment correlation as well as the kappa, modified kappa and the intra-class correlation coefficient (3,1). An attribute agreement analysis was conducted to determine the percent of inter-rater and intra-rater agreement across individual push-ups. The results indicated that Raters varied a great deal in assessing push-ups. Over the 4 trials of 15 participants, the overall scores of the Raters varied between 3.0 and 35.7 push-ups. Post hoc comparisons found that there was significant increase in the grand mean of push-ups from trials 1-3 to trial 4 (p < 0.05). Also, there was a significant difference among raters over the 4 trials (p < 0.05). Pearson correlation coefficients for inter-rater and intra-rater reliability identified inter-rater reliability coefficients were between 0.10 and 0.97. Intra-rater coefficients were between 0.48 and 0.99. Intra-rater agreement for individual push-up repetitions ranged from 41.8% to 84.8%. The results indicated that the raters failed to assess the same push-up repetition with the same score (below 70% agreement) as well as failed to agree when viewed between raters (29%). Interestingly, as previously mentioned, scores on trial 4 increased significantly which might have been caused by rater drift or that the Raters did not maintain the push-up standard over the trials. It does appear that the final push-up scores received by each participant was a close approximation of actual performance (within 65%) but when assessing physical performance for retention in the Army, a more reliable test might be considered. C1 [Fielitz, Lynn; Coelho, Jeffrey; Horne, Thomas; Brechue, William] US Mil Acad, Dept Phys Educ, 727 Brewerton Rd, West Point, NY 10996 USA. RP Fielitz, L (reprint author), US Mil Acad, Dept Phys Educ, 727 Brewerton Rd, West Point, NY 10996 USA. NR 25 TC 0 Z9 0 U1 0 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD FEB PY 2016 VL 181 IS 2 BP 167 EP 172 DI 10.7205/MILMED-D-14-00533 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA DI3ND UT WOS:000373404500019 PM 26837086 ER PT J AU Abt, JP Perlsweig, K Nagai, T Sell, TC Wirt, MD Lephart, SM AF Abt, John P. Perlsweig, Katherine Nagai, Takashi Sell, Timothy C. Wirt, Michael D. Lephart, Scott M. TI Effects of Age and Military Service on Strength and Physiological Characteristics of US Army Soldiers SO MILITARY MEDICINE LA English DT Article ID TRAINING-RELATED INJURIES; MAXIMAL HEART-RATE; PHYSICAL-FITNESS; RISK-FACTORS; OPERATIONAL STRESS; AEROBIC CAPACITY; BODY-COMPOSITION; SEDENTARY MEN; PERFORMANCE; RELIABILITY AB Soldiers must maintain tactical performance capabilities over the course of their career. Loss in physical readiness may be a function of age and the operational demands associated with increasing years of service. The purpose of this study was to assess strength and physiological characteristics in different cohorts of U.S. Army Soldiers based on years of service and age. A total of 253 Soldiers (age: 28.1 +/- 6.8 years; height: 1.76 +/- 0.11 m; mass: 84.1 +/- 12.2 kg) participated. Individual subject cohorts were created based on years of service (1-5 years, 6-10 years, 11-15 years) and age (20-24 years, 25-29 years, 30-34 years, 35-39 years, 40-44 years). Testing included shoulder, knee, ankle, and torso strength, aerobic capacity/lactate threshold, anaerobic power/capacity, and body composition/total mass. Those with 11 to 15 years of service and between ages 30 and 34 had a higher percentage of body fat, and lower aerobic capacity and lactate threshold than younger Soldiers with fewer years of service. Physical training interventions should focus on maintenance of physiological characteristics to offset the loss of readiness at the similar time point of 11 to 15 years of service and 30 to 34 years of age. C1 [Abt, John P.; Lephart, Scott M.] Univ Kentucky, Coll Hlth Sci, UK Wethington Bldg,Room 123,900 South Limestone, Lexington, KY 40536 USA. [Perlsweig, Katherine; Nagai, Takashi; Sell, Timothy C.] Univ Pittsburgh, Neuromuscular Res Lab, Warrior Human Performance Res Ctr, 3830 South Water St, Pittsburgh, PA 15203 USA. [Wirt, Michael D.] US Army Inst Surg Res, 3698 Chambers Pass,Bldg 36111, Jbsa Ft Sam Houston, TX 78234 USA. RP Abt, JP (reprint author), Univ Kentucky, Coll Hlth Sci, UK Wethington Bldg,Room 123,900 South Limestone, Lexington, KY 40536 USA. FU U.S. Army Medical Research and Materiel Command [W81XWH-11-2-0097] FX This work was supported by the U.S. Army Medical Research and Materiel Command No. W81XWH-11-2-0097. Opinions, interpretations, conclusions, and recommendations are those of the authors and not necessarily endorsed by the Department of Defense or U.S. Army. NR 56 TC 1 Z9 1 U1 2 U2 4 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD FEB PY 2016 VL 181 IS 2 BP 173 EP 179 DI 10.7205/MILMED-D-15-00036 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA DI3ND UT WOS:000373404500020 PM 26837087 ER PT J AU Kamapantula, BK Mayo, ML Perkins, EJ Ghosh, P AF Kamapantula, Bhanu K. Mayo, Michael L. Perkins, Edward J. Ghosh, Preetam TI The Structural Role of Feed-Forward Loop Motif in Transcriptional Regulatory Networks SO MOBILE NETWORKS & APPLICATIONS LA English DT Article; Proceedings Paper CT 8th International Conference on Bio-Inspired Information and Communications Technologies (BICT) CY DEC 01-03, 2014 CL Boston, MA DE Biological robustness; Transcriptional network; Feed-forward loop; Signal transduction ID ESCHERICHIA-COLI; COMPLEX NETWORKS AB We present multiple approaches to identify the significance of topological metrics that contribute to biological network robustness. We examine and compare the communication efficiency of transcriptional networks extracted from the bacterium Escherichia coli and the baker's yeast Saccharomyces cerevisiae using discrete event simulation based in silico experiments. The packet receipt rate is used as a dynamical metric to understand information flow, while unsupervised machine learning techniques are used to examine underlying relationships inherent to the network topology. To this effect, we defined sixteen features based on structural/topological significance, such as transcriptional motifs, and other traditional metrics, such as network density and average shortest path, among others. Support vector classification is used with these features after parameters were identified using a cross-validation grid-search method. Feature ranking is performed using analysis of variance F-value metric. We found that feed-forward loop (FFL) based features consistently show up as significant in both the bacterial and yeast networks, even at different noise levels. We then use a supervised machine learning technique (random forests) to investigate the structural prominence of the FFL motif in information transmission using subnetworks (larger sample size compared to the unsupervised approach) extracted from Escherichia coli transcriptional regulatory network. Further, we study the role of FFLs in signal transduction within the complete Escherichia coli regulatory network. Although our work reveals a minimal role of FFLs in signal transduction, it highlights the structural role of FFLs in information transmission captured by random forest regression. This work paves the way to design specialized engineered systems, such as wireless sensor networks, that exploit topological properties of natural networks to attain maximum efficiency. C1 [Kamapantula, Bhanu K.; Ghosh, Preetam] Virginia Commonwealth Univ, Richmond, VA USA. [Mayo, Michael L.; Perkins, Edward J.] US Army, Engineer Res & Dev Ctr, Vicksburg, MS USA. RP Ghosh, P (reprint author), Virginia Commonwealth Univ, Richmond, VA USA. EM kamapantulbk@vcu.edu; Michael.L.Mayo@usace.army.mil; Edward.J.Perkins@erdc.dren.mil; pghosh@vcu.edu NR 21 TC 0 Z9 0 U1 1 U2 2 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1383-469X EI 1572-8153 J9 MOBILE NETW APPL JI Mobile Netw. Appl. PD FEB PY 2016 VL 21 IS 1 BP 191 EP 205 DI 10.1007/s11036-016-0708-6 PG 15 WC Computer Science, Hardware & Architecture; Computer Science, Information Systems; Telecommunications SC Computer Science; Telecommunications GA DI7MA UT WOS:000373683400016 ER PT J AU Gage, EA Cooper, DJ Bultema, B McKernan, C Lichvar, R AF Gage, Edward A. Cooper, David J. Bultema, Betsy McKernan, Cristina Lichvar, Robert TI Developing a Field-Tested Wetland Indicator Rating for Blue Spruce (Picea Pungens) in the Southern Rocky Mountains SO WETLANDS LA English DT Article DE Wetland delineation; Hydrophyte; National Wetland Plant List; Regulation; Picea pungens ID NORTH-AMERICAN MONSOON; MODELS; PRECIPITATION; DISTRIBUTIONS; ENGELMANNII; EXPLANATION; VARIABILITY; REGRESSION; COLORADO; MAXENT AB To be identified as a wetland under U.S. Federal regulations, a site must, under normal circumstances, support vegetation dominated by hydrophytes. A list of hydrophytes and their wetland indicator rating is published by the U.S. Army Corps of Engineers as the National Wetland Plant List (NWPL) and is the basis for assessing the vegetation criteria of Federal wetland delineation manuals. Ratings are primarily based on expert opinion and few empirical studies have been done, particularly at landscape scales. In this study, we developed an approach for quantifying plant indicator ratings at broad spatial scales and used it to estimate the frequency that Picea pungens Engelm. (Colorado blue spruce) occurs in wetlands across a 22,921 km(2) study area in the southern Rocky Mountains. Species distribution models were developed and used to inform a multistage field sampling design. Wetland soil and hydrology indicators were assessed around 423 randomly selected trees in 22 HUC12 watersheds. Only 16.5 % of trees occurred in wetlands, suggesting that a rating of facultative upland (FACU) is more appropriate than the currently published rating of facultative (FAC) for our study area. This study demonstrates that it is feasible to quantitatively evaluate ratings for species even at broad landscape scales. C1 [Gage, Edward A.; Cooper, David J.; Bultema, Betsy; McKernan, Cristina] Colorado State Univ, Dept Forest & Rangeland Stewardship, Ft Collins, CO 80523 USA. [Lichvar, Robert] US Army Corps Engineers, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Gage, EA (reprint author), Colorado State Univ, Dept Forest & Rangeland Stewardship, Ft Collins, CO 80523 USA. EM edward.gage@colostate.edu FU U.S. Environmental Protection Agency; U.S. Fish and Wildlife Service; U.S. Army Corps of Engineers under the Wetland Regulatory Assistance Program (WRAP) FX Funding for this study was provided by the U.S. Environmental Protection Agency, U.S. Fish and Wildlife Service, and the U.S. Army Corps of Engineers under the Wetland Regulatory Assistance Program (WRAP). Special thanks to Dr. Anthony Olson of EPA, Western Ecology Division, for discussions related to our sampling design and methods. Thanks to Joanna Harter, Sven Bultema, Dan Kotter, and Amanda Snyder for assistance in the field and to Mary Butterwick for input on study objectives and design. Thanks also to Catherine Jarnevich for help with species distribution modeling. NR 52 TC 0 Z9 0 U1 2 U2 4 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0277-5212 EI 1943-6246 J9 WETLANDS JI Wetlands PD FEB PY 2016 VL 36 IS 1 BP 111 EP 120 DI 10.1007/s13157-015-0721-8 PG 10 WC Ecology; Environmental Sciences SC Environmental Sciences & Ecology GA DI6XR UT WOS:000373644000010 ER PT J AU Islam, D Lombardini, E Ruamsap, N Imerbsin, R Khantapura, P Teo, I Neesanant, P Gonwong, S Yongvanitchit, K Swierczewski, BE Mason, CJ Shaunak, S AF Islam, Dilara Lombardini, Eric Ruamsap, Nattaya Imerbsin, Rawiwan Khantapura, Patchariya Teo, Ian Neesanant, Pimmnapar Gonwong, Siriphan Yongvanitchit, Kosol Swierczewski, Brett E. Mason, Carl J. Shaunak, Sunil TI Controlling the cytokine storm in severe bacterial diarrhoea with an oral Toll-like receptor 4 antagonist SO IMMUNOLOGY LA English DT Article DE bacterial diarrhoea; cytokines; inflammation; Toll-like receptor-4 ID NORMAL RHESUS MACAQUES; SHIGELLA-FLEXNERI; T-CELLS; NECROTIZING ENTEROCOLITIS; NONHUMAN-PRIMATES; INTERFERON-BETA; SHIGA TOXIN; GUT; NEUTROPHILS; INDUCTION AB Shigella dysenteriae causes the most severe of all infectious diarrhoeas and colitis. We infected rhesus macaques orally and also treated them orally with a small and non-absorbable polypropyletherimine dendrimer glucosamine that is a Toll-like receptor-4 (TLR4) antagonist. Antibiotics were not given for this life-threatening infection. Six days later, the clinical score for diarrhoea, mucus and blood was 54% lower, colon interleukin-8 and interleukin-6 were both 77% lower, and colon neutrophil infiltration was 75% less. Strikingly, vasculitis did not occur and tissue fibrin thrombi were reduced by 67%. There was no clinical toxicity or adverse effect of dendrimer glucosamine on systemic immunity. This is the first report in non-human primates of the therapeutic efficacy of a small and orally bioavailable TLR antagonist in severe infection. Our results show that an oral TLR4 antagonist can enable controlled resolution of the infection-related-inflammatory response and can also prevent neutrophil-mediated gut wall necrosis in severe infectious diarrhoeas. C1 [Islam, Dilara; Ruamsap, Nattaya; Khantapura, Patchariya; Neesanant, Pimmnapar; Gonwong, Siriphan; Yongvanitchit, Kosol; Swierczewski, Brett E.; Mason, Carl J.] Armed Forces Res Inst Med Sci, Dept Enter Dis, Bangkok 10400, Thailand. [Lombardini, Eric; Imerbsin, Rawiwan] Armed Forces Res Inst Med Sci, Dept Vet Med, Bangkok 10400, Thailand. [Teo, Ian; Shaunak, Sunil] Univ London Imperial Coll Sci Technol & Med, Dept Med, Hammersmith Campus, London W12 0NN, England. [Teo, Ian; Shaunak, Sunil] Univ London Imperial Coll Sci Technol & Med, Dept Infect Dis, Hammersmith Campus, London W12 0NN, England. [Teo, Ian; Shaunak, Sunil] Univ London Imperial Coll Sci Technol & Med, Dept Immun, Hammersmith Campus, London W12 0NN, England. [Shaunak, Sunil] Univ London Imperial Coll Sci Technol & Med, Dept Pathol, Hammersmith Campus, London W12 0NN, England. [Shaunak, Sunil] Univ London Imperial Coll Sci Technol & Med, Dept Chem, Hammersmith Campus, London W12 0NN, England. RP Shaunak, S (reprint author), Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Fac Med, Du Cane Rd, London W12 0NN, England. EM s.shaunak@imperial.ac.uk OI MASON, CARL/0000-0002-3676-2811 FU NIAID under Inter-Agency Agreement [Y1-AI-4906-03]; US Army Medical Research & Materiel Command; Imperial Biomedical Research Centre; Williams Trust FX SS, DI, IT and CJM conceived and designed the study. RI was the vet and EL was the pathologist. DI, NR, PK, PN, SG, and KY performed the animal study and tissue analysis. The manuscript was written by SS, DI, EL, IT, BES and CJM with input from all authors. We are grateful for the technical support provided by Kesara Chumpolkulwong and Alongkorn Hanrujirakomjorn for veterinary procedures, Amnat Andang, Rachata Jecksaeng, Mana Saitasao and Siwakorn Sirisrisopa for husbandry, and Paphavee Lertsethtakarn, Sathit Pichyangkul, Ajchar Aksomboon, Nuanpan Khemnu, Kaewkanya Nakjarung and Sasikorn Silapong for assays. This study was funded by NIAID under Inter-Agency Agreement Y1-AI-4906-03 and US Army Medical Research & Materiel Command and Imperial Biomedical Research Centre and Williams Trust grants to CJM, BES and SS. NR 60 TC 1 Z9 1 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0019-2805 EI 1365-2567 J9 IMMUNOLOGY JI Immunology PD FEB PY 2016 VL 147 IS 2 BP 178 EP 189 DI 10.1111/imm.12549 PG 12 WC Immunology SC Immunology GA DH6TY UT WOS:000372926100005 PM 26496144 ER PT J AU Bennett, JW Yadava, A Tosh, D Sattabongkot, J Komisar, J Ware, LA McCarthy, WF Cowden, JJ Regules, J Spring, MD Paolino, K Hartzell, JD Cummings, JF Richie, TL Lumsden, J Kamau, E Murphy, J Lee, C Parekh, F Birkett, A Cohen, J Ballou, WR Polhemus, ME Vanloubbeeck, YF Vekemans, J Ockenhouse, CF AF Bennett, Jason W. Yadava, Anjali Tosh, Donna Sattabongkot, Jetsumon Komisar, Jack Ware, Lisa A. McCarthy, William F. Cowden, Jessica J. Regules, Jason Spring, Michele D. Paolino, Kristopher Hartzell, Joshua D. Cummings, James F. Richie, Thomas L. Lumsden, Joanne Kamau, Edwin Murphy, Jittawadee Lee, Cynthia Parekh, Falgunee Birkett, Ashley Cohen, Joe Ballou, W. Ripley Polhemus, Mark E. Vanloubbeeck, Yannick F. Vekemans, Johan Ockenhouse, Christian F. TI Phase 1/2a Trial of Plasmodium vivax Malaria Vaccine Candidate VMP001/AS01(B) in Malaria-Naive Adults: Safety, Immunogenicity, and Efficacy SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID CIRCUMSPOROZOITE PROTEIN; SPOROZOITES; RTS,S/AS02A; VOLUNTEERS; ANTIBODIES; PRIMAQUINE AB Background A vaccine to prevent infection and disease caused by Plasmodium vivax is needed both to reduce the morbidity caused by this parasite and as a key component in efforts to eradicate malaria worldwide. Vivax malaria protein 1 (VMP001), a novel chimeric protein that incorporates the amino-and carboxy-terminal regions of the circumsporozoite protein (CSP) and a truncated repeat region that contains repeat sequences from both the VK210 (type 1) and the VK247 (type 2) parasites, was developed as a vaccine candidate for global use. Methods We conducted a first-in-human Phase 1 dose escalation vaccine study with controlled human malaria infection (CHMI) of VMP001 formulated in the GSK Adjuvant System AS01(B). A total of 30 volunteers divided into 3 groups (10 per group) were given 3 intramuscular injections of 15 mu g, 30 mu g, or 60 mu g respectively of VMP001, all formulated in 500 mu L of AS01(B) at each immunization. All vaccinated volunteers participated in a P. vivax CHMI 14 days following the third immunization. Six non-vaccinated subjects served as infectivity controls. Results The vaccine was shown to be well tolerated and immunogenic. All volunteers generated robust humoral and cellular immune responses to the vaccine antigen. Vaccination did not induce sterile protection; however, a small but significant delay in time to parasitemia was seen in 59% of vaccinated subjects compared to the control group. An association was identified between levels of anti-type 1 repeat antibodies and prepatent period. Significance This trial was the first to assess the efficacy of a P. vivax CSP vaccine candidate by CHMI. The association of type 1 repeat-specific antibody responses with delay in the prepatency period suggests that augmenting the immune responses to this domain may improve strain-specific vaccine efficacy. The availability of a P. vivax CHMI model will accelerate the process of P. vivax vaccine development, allowing better selection of candidate vaccines for advancement to field trials. C1 [Bennett, Jason W.; Yadava, Anjali; Tosh, Donna; Komisar, Jack; Ware, Lisa A.; Cowden, Jessica J.; Regules, Jason; Spring, Michele D.; Paolino, Kristopher; Cummings, James F.; Lumsden, Joanne; Kamau, Edwin; Murphy, Jittawadee; Polhemus, Mark E.; Ockenhouse, Christian F.] Walter Reed Army Inst Res, Malaria Vaccine Brach, Silver Spring, MD USA. [Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [McCarthy, William F.] US Army Med Mat Dev Act, Frederick, MD USA. [Hartzell, Joshua D.] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA. [Richie, Thomas L.] Naval Med Res Ctr, Silver Spring, MD USA. [Lee, Cynthia; Parekh, Falgunee; Birkett, Ashley] PATH MVI, Washington, DC USA. [Cohen, Joe; Ballou, W. Ripley; Vanloubbeeck, Yannick F.; Vekemans, Johan] GSK Vaccines, Rixensart, Belgium. [Cohen, Joe] Cohen Biopharm Consulting, Brussels, Belgium. RP Yadava, A (reprint author), Walter Reed Army Inst Res, Malaria Vaccine Brach, Silver Spring, MD USA. EM Anjali.Yadava.Civ@mail.mil FU Military Infectious Diseases Research Program, Maryland; PATH-MVI FX This work was supported by intramural funding from the Military Infectious Diseases Research Program, Maryland and PATH-MVI. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 24 TC 8 Z9 8 U1 1 U2 1 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD FEB PY 2016 VL 10 IS 2 AR e0004423 DI 10.1371/journal.pntd.0004423 PG 16 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA DH1TH UT WOS:000372567300039 PM 26919472 ER PT J AU Alera, MT Srikiatkhachorn, A Velasco, JM Tac-An, IA Lago, CB Clapham, HE Fernandez, S Levy, JW Thaisomboonsuk, B Klungthong, C Macareo, LR Nisalak, A Hermann, L Villa, D Yoon, IK AF Theresa Alera, Maria Srikiatkhachorn, Anon Mark Velasco, John Tac-An, Ilya A. Lago, Catherine B. Clapham, Hannah E. Fernandez, Stefan Levy, Jens W. Thaisomboonsuk, Butsaya Klungthong, Chonticha Macareo, Louis R. Nisalak, Ananda Hermann, Laura Villa, Daisy Yoon, In-Kyu TI Incidence of Dengue Virus Infection in Adults and Children in a Prospective Longitudinal Cohort in the Philippines SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID HEMORRHAGIC-FEVER; DISEASE; EPIDEMIOLOGY; THAILAND; TRANSMISSION; INAPPARENT; FREQUENCY; INDONESIA; RISK AB Background The mean age of dengue has been increasing in some but not all countries. We sought to determine the incidence of dengue virus (DENV) infection in adults and children in a prospective cohort study in the Philippines where dengue is hyperendemic. Methodology/Principal Findings A prospective cohort of subjects >= 6 months old in Cebu City, Philippines, underwent active community-based surveillance for acute febrile illnesses by weekly contact. Fever history within the prior seven days was evaluated with an acute illness visit followed by 2, 5, and 8-day, and 3-week convalescent visits. Blood was collected at the acute and 3-week visits. Scheduled visits took place at enrolment and 12 months that included blood collections. Acute samples were tested by DENV PCR and acute/convalescent samples by DENV IgM/IgG ELISA to identify symptomatic infections. Enrolment and 12-month samples were tested by DENV hemagglutination inhibition (HAI)assay to identify subclinical infections. Of 1,008 enrolled subjects, 854 completed all study activities at 12 months per-protocol undergoing 868 person-years of surveillance. The incidence of symptomatic and subclinical infections was 1.62 and 7.03 per 100 person-years, respectively. However, in subjects > 15 years old, only one symptomatic infection occurred whereas 27 subclinical infections were identified. DENV HAI seroprevalence increased sharply with age with baseline multitypic HAIs associated with fewer symptomatic infections. Using a catalytic model, the historical infection rate among dengue naive individuals was estimated to be high at 11-22%/year. Conclusions/Significance In this hyperendemic area with high seroprevalence of multitypic DENV HAIs in adults, symptomatic dengue rarely occurred in individuals older than 15 years. Our findings demonstrate that dengue is primarily a pediatric disease in areas with high force of infection. However, the average age of dengue could increase if force of infection decreases over time, as is occurring in some hyperendemic countries such as Thailand. C1 [Theresa Alera, Maria; Mark Velasco, John; Lago, Catherine B.] Philippines AFRIMS Virol Res Unit, CAP Bldg, Cebu, Philippines. [Srikiatkhachorn, Anon] Univ Massachusetts, Sch Med, Dept Med, Div Infect Dis & Immunol, Worcester, MA USA. [Tac-An, Ilya A.; Villa, Daisy] Cebu City Hlth Dept, Cebu, Philippines. [Clapham, Hannah E.] Johns Hopkins Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA. [Fernandez, Stefan; Levy, Jens W.; Thaisomboonsuk, Butsaya; Klungthong, Chonticha; Macareo, Louis R.; Nisalak, Ananda; Hermann, Laura; Yoon, In-Kyu] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Hermann, Laura] Univ Toronto, Dept Med, Toronto, ON, Canada. [Yoon, In-Kyu] Int Vaccine Inst, Dengue Vaccine Initiat, Seoul, South Korea. RP Alera, MT (reprint author), Philippines AFRIMS Virol Res Unit, CAP Bldg, Cebu, Philippines. EM MariaTheresa.Alera.ca@afrims.org FU Armed Forces Health Surveilance Center-Global Emerging Infections Surveillance and Response System [P0140_14_AF]; Canadian Institutes of Health Research Fellowship FX This research was funded by a grant from the Armed Forces Health Surveilance Center-Global Emerging Infections Surveillance and Response System (Grant P0140_14_AF) and a Canadian Institutes of Health Research Fellowship for LH. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 29 TC 2 Z9 2 U1 1 U2 5 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD FEB PY 2016 VL 10 IS 2 AR e0004337 DI 10.1371/journal.pntd.0004337 PG 14 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA DH1TH UT WOS:000372567300006 PM 26845762 ER PT J AU Warren, TK Whitehouse, CA Wells, J Welch, L Charleston, JS Heald, A Nichols, DK Mattix, ME Palacios, G Kugleman, JR Iversen, PL Bavari, S AF Warren, Travis K. Whitehouse, Chris A. Wells, Jay Welch, Lisa Charleston, Jay S. Heald, Alison Nichols, Donald K. Mattix, Marc E. Palacios, Gustavo Kugleman, Jeffrey R. Iversen, Patrick L. Bavari, Sina TI Delayed Time-to-Treatment of an Antisense Morpholino Oligomer Is Effective against Lethal Marburg Virus Infection in Cynomolgus Macaques SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID EBOLA-VIRUS; HEMORRHAGIC-FEVER; NONHUMAN-PRIMATES; POSTEXPOSURE PROTECTION; CELL-CULTURES; INHIBITION; MICE; PATHOGENESIS; AVI-7288; EFFICACY AB Marburg virus (MARV) is an Ebola-like virus in the family Filovirdae that causes sporadic outbreaks of severe hemorrhagic fever with a case fatality rate as high as 90%. AVI-7288, a positively charged antisense phosphorodiamidate morpholino oligomer (PMOplus) targeting the viral nucleoprotein gene, was evaluated as a potential therapeutic intervention for MARV infection following delayed treatment of 1, 24, 48, and 96 h post-infection (PI) in a nonhuman primate lethal challenge model. A total of 30 cynomolgus macaques were divided into 5 groups of 6 and infected with 1,830 plaque forming units of MARV subcutaneously. AVI-7288 was administered by bolus infusion daily for 14 days at 15 mg/kg body weight. Survival was the primary endpoint of the study. While none (0 of 6) of the saline group survived, 83-100% of infected monkeys survived when treatment was initiated 1, 24, 48, or 96 h post-infection (PI). The antisense treatment also reduced serum viremia and inflammatory cytokines in all treatment groups compared to vehicle controls. The antibody immune response to virus was preserved and tissue viral antigen was cleared in AVI-7288 treated animals. These data show that AVI-7288 protects NHPs against an otherwise lethal MARV infection when treatment is initiated up to 96 h PI. C1 [Warren, Travis K.; Whitehouse, Chris A.; Wells, Jay; Welch, Lisa; Bavari, Sina] US Army, Med Res Inst Infect Dis, Mol & Translat Sci Div, Frederick, MD USA. [Charleston, Jay S.; Heald, Alison; Iversen, Patrick L.] Sarepta Therapeut Inc, Cambridge, MA USA. [Nichols, Donald K.; Mattix, Marc E.] US Army, Med Res Inst Infect Dis, Div Pathol, Frederick, MD USA. [Palacios, Gustavo; Kugleman, Jeffrey R.] US Army, Med Res Inst Infect Dis, Ctr Genome Sci, Frederick, MD USA. [Mattix, Marc E.] WIL Res, Ashland, OH USA. RP Bavari, S (reprint author), US Army, Med Res Inst Infect Dis, Mol & Translat Sci Div, Frederick, MD USA. EM sina.bavari.civ@mail.mil OI Palacios, Gustavo/0000-0001-5062-1938 FU Joint Product Management Office of BioDefense Therapeutics (BDTx) [W9113M-10-C-0056] FX This work was conducted under a contract (W9113M-10-C-0056) with the Joint Product Management Office of BioDefense Therapeutics (BDTx). BD-Tx is a component of the Medical Countermeasure Systems Joint Project Management Office (JPM-MCS) within the U.S. Department of Defense's Joint Program Executive Office for Chemical and Biological Defense. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 32 TC 1 Z9 1 U1 2 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD FEB PY 2016 VL 10 IS 2 AR e0004456 DI 10.1371/journal.pntd.0004456 PG 18 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA DH1TH UT WOS:000372567300061 PM 26901785 ER PT J AU Lim, RB AF Lim, Robert B. TI Comment on: Rhabdomyolysis after bariatric surgery: a multicenter, prospective study on incidence, risk factors, and therapeutic strategy in a cohort from South-Italy SO SURGERY FOR OBESITY AND RELATED DISEASES LA English DT Editorial Material C1 [Lim, Robert B.] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. RP Lim, RB (reprint author), Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1550-7289 EI 1878-7533 J9 SURG OBES RELAT DIS JI Surg. Obes. Relat. Dis. PD FEB PY 2016 VL 12 IS 2 BP 390 EP 391 PG 2 WC Surgery SC Surgery GA DH3FL UT WOS:000372672800032 PM 26968502 ER PT J AU Cornell, R Wrobel, E Anderson, PE AF Cornell, Rodger Wrobel, Erik Anderson, Paul E. TI Research and Development of High-performance Explosives SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS LA English DT Article DE Engineering; Issue 108; Explosives; Detonation; Testing; Fiber-optic; Photo Doppler Velocimetry ID ALUMINUM; DETONATION AB Developmental testing of high explosives for military applications involves small-scale formulation, safety testing, and finally detonation performance tests to verify theoretical calculations. small-scale For newly developed formulations, the process begins with small-scale mixes, thermal testing, and impact and friction sensitivity. Only then do subsequent larger scale formulations proceed to detonation testing, which will be covered in this paper. Recent advances in characterization techniques have led to unparalleled precision in the characterization of early-time evolution of detonations. The new technique of photo-Doppler velocimetry (PDV) for the measurement of detonation pressure and velocity will be shared and compared with traditional fiber-optic detonation velocity and plate-dent calculation of detonation pressure. In particular, the role of aluminum in explosive formulations will be discussed. Recent developments led to the development of explosive formulations that result in reaction of aluminum very early in the detonation product expansion. This enhanced reaction leads to changes in the detonation velocity and pressure due to reaction of the aluminum with oxygen in the expanding gas products. C1 [Cornell, Rodger; Wrobel, Erik] US Army ARDEC, Detonat Phys Branch, Picatinny Arsenal, Wharton, NJ USA. [Anderson, Paul E.] US Army ARDEC, Explos Res Branch, Picatinny Arsenal, Wharton, NJ USA. RP Anderson, PE (reprint author), US Army ARDEC, Explos Res Branch, Picatinny Arsenal, Wharton, NJ USA. EM paul.e.anderson64.civ@mail.mil FU Future Requirement of Enhanced Energetics for Decisive Munitions (FREEDM) Program FX The authors would like to thank the Future Requirement of Enhanced Energetics for Decisive Munitions (FREEDM) Program for funding, Mike VanDeWaal and Gerard Gillen for their assistance in testing, Paula Cook for formulations assistance, and Ralph Acevedo and Brian Travers for pressing of the samples. NR 10 TC 0 Z9 0 U1 1 U2 3 PU JOURNAL OF VISUALIZED EXPERIMENTS PI CAMBRIDGE PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA SN 1940-087X J9 JOVE-J VIS EXP JI J. Vis. Exp. PD FEB PY 2016 IS 108 AR e52950 DI 10.3791/52950 PG 12 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DH0WF UT WOS:000372504100003 ER PT J AU Robinson, RM Kothera, CS Sanner, RM Wereley, NM AF Robinson, Ryan M. Kothera, Curt S. Sanner, Robert M. Wereley, Norman M. TI Nonlinear Control of Robotic Manipulators Driven by Pneumatic Artificial Muscles SO IEEE-ASME TRANSACTIONS ON MECHATRONICS LA English DT Article DE Adaptive control; manipulator control; McKibben actuator; neural network control; pneumatic artificial muscle (PAM); robotic manipulator; sliding mode control ID SLIDING-MODE CONTROL; ADAPTIVE-CONTROL; ACTUATORS AB Lightweight, compliant actuators are particularly desirable in safety-conscious robotic systems intended for interaction with humans. Pneumatic artificial muscles (PAMs) exhibit these characteristics and are capable of higher specific work than comparably sized hydraulic actuators and electric motors. However, control of PAM-actuated systems has proven difficult due to the highly nonlinear nature of the actuators and the pneumatic systems driving their actuation. This study develops and investigates the performance of three advanced control strategies-sliding mode control, adaptive sliding mode control, and adaptive neural network (ANN) control-each containing a distinct level of a priori model knowledge, to enable smooth and accurate motion tracking of a single degree-of-freedom PAM-actuated manipulator. Originally developed by J.-J. Slotine and R.M. Sanner, the specific controllers employed in this study are significantly modified for application to pneumatically actuated open-chain manipulators with complex nonlinear dynamics. The two adaptive controllers are updated online and require no pretraining step. Several experiments are performed with each controller to evaluate and compare closed-loop tracking performance. Results highlight the dependence of a preferred control strategy on the level of model completeness and quality, and suggest that in most PAM-actuated manipulator scenarios, the ANN controller is preferable because it does not require a model of the pneumatic system or joint mechanism design, which can be difficult and time consuming to characterize, and is robust to changes in PAM actuator characteristics (due to fatigue or replacement). C1 [Robinson, Ryan M.] Army Res Lab, Adelphi, MD 20783 USA. [Kothera, Curt S.] InnoVital Syst Inc, Beltsville, MD 20705 USA. [Sanner, Robert M.; Wereley, Norman M.] Univ Maryland, Dept Aerosp Engn, College Pk, MD 20742 USA. RP Robinson, RM (reprint author), Army Res Lab, Adelphi, MD 20783 USA.; Kothera, CS (reprint author), InnoVital Syst Inc, Beltsville, MD 20705 USA.; Sanner, RM; Wereley, NM (reprint author), Univ Maryland, Dept Aerosp Engn, College Pk, MD 20742 USA. EM ryan.robinson14.ctr@mail.mil; curt@innovitalsystems.com; rmsanner@umd.edu; wereley@umd.edu OI Wereley, Norman M. /0000-0002-9932-6988 FU L-3 Communications Fellowship FX This work was supported in part by the L-3 Communications Fellowship awarded to R. M. Robinson at the University of Maryland. NR 32 TC 2 Z9 2 U1 10 U2 22 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1083-4435 EI 1941-014X J9 IEEE-ASME T MECH JI IEEE-ASME Trans. Mechatron. PD FEB PY 2016 VL 21 IS 1 BP 55 EP 68 DI 10.1109/TMECH.2015.2483520 PG 14 WC Automation & Control Systems; Engineering, Manufacturing; Engineering, Electrical & Electronic; Engineering, Mechanical SC Automation & Control Systems; Engineering GA DG4BC UT WOS:000372013900008 ER PT J AU Gasier, HG Young, CR Gaffney-Stomberg, E McAdams, DC Lutz, LJ McClung, JP AF Gasier, Heath G. Young, Colin R. Gaffney-Stomberg, Erin McAdams, Douglas C. Lutz, Laura J. McClung, James P. TI Cardiometabolic Health in Submariners Returning from a 3-Month Patrol SO NUTRIENTS LA English DT Article DE adipokines; chemokines; diet; inflammation; insulin resistance; metabolic syndrome; physical activity; obesity ID METABOLIC SYNDROME; INSULIN-RESISTANCE; WEIGHT REGAIN; RISK-FACTORS; MASS INDEX; SHIFT WORK; OBESITY; DISEASE; LEPTIN; FAT AB Confined space, limited exercise equipment, rotating shift work and reduced sleep may affect cardiometabolic health in submariners. To test this hypothesis, 53 male U.S. Submariners (20-39 years) were studied before and after a 3-month routine submarine patrol. Measures included anthropometrics, dietary and physical activity, biomarkers of cardiometabolic health, energy and appetite regulation, and inflammation. Before deployment, 62% of submariners had a body fat % (BF%) 25% (obesity), and of this group, 30% met the criteria for metabolic syndrome. In obese volunteers, insulin, the homeostatic model assessment of insulin resistance (HOMA-IR), leptin, the leptin/adiponectin ratio, and pro-inflammatory chemokines growth-related oncogene and macrophage-derived chemokine were significantly higher compared to non-obese submariners. Following the patrol, a significant mean reduction in body mass (5%) and fat-mass (11%) occurred in the obese group as a result of reduced energy intake (similar to 2000 kJ) during the patrol; and, independent of group, modest improvements in serum lipids and a mean reduction in interferon -induced protein 10 and monocyte chemotactic protein 1 were observed. Since 43% of the submariners remained obese, and 18% continued to meet the criteria for metabolic syndrome following the patrol, the magnitude of weight loss was insufficient to completely abolish metabolic dysfunction. Submergence up to 3-months, however, does not appear to be the cause of obesity, which is similar to that of the general population. C1 [Gasier, Heath G.] Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, Bethesda, MD 20814 USA. [Young, Colin R.] Naval Submarine Med Res Lab, Groton, CT 06349 USA. [Gaffney-Stomberg, Erin; Lutz, Laura J.; McClung, James P.] US Army, Environm Med Res Inst, Natick, MA 01760 USA. [McAdams, Douglas C.] Submarine Grp Nine, Silverdale, WA 98315 USA. RP Gasier, HG (reprint author), Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, Bethesda, MD 20814 USA. EM heath.gasier@usuhs.edu; colin.r.young.mil@mail.mil; erin.g.stomberg.civ@mail.mil; douglas.c.mcadams.mil@mail.mil; laura.j.lutz2.civ@mail.mil; james.p.mcclung8.civ@mail.mil OI Young, Colin/0000-0002-4786-5840 FU Office of Naval Research; Warfighter Performance Department [34, N0001411WX20143]; US Army Medical Research and Materiel Command FX We would like to extend our gratitude to the USS Nevada Gold Crew (SSBN733) for their participation in this study. In addition, we would like to thank the Commander of Submarine Force, the Commanding Officers of Submarine Group 9, and Submarine Squadron 17, and the Officer in Charge of Naval Branch Health Clinic, Bangor, WA for their permission to conduct this investigation. We would also like to thank David Fothergill and Andrew Young for their assistance in improving the quality of this manuscript, and to Lee Margolis, Nancy Murphy, David Gonzalez, Reginald Clyburn, Glen Rossman, Darrin Way, Shawn Soutiere and Jennifer Rood for their technical assistance. This work was supported by the Office of Naval Research, Warfighter Performance Department (Code 34), award number N0001411WX20143 and the US Army Medical Research and Materiel Command. NR 47 TC 2 Z9 2 U1 1 U2 2 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 2072-6643 J9 NUTRIENTS JI Nutrients PD FEB PY 2016 VL 8 IS 2 AR 85 DI 10.3390/nu8020085 PG 12 WC Nutrition & Dietetics SC Nutrition & Dietetics GA DG1KT UT WOS:000371827600010 PM 26867201 ER PT J AU Corron, NJ Cooper, RM Blakely, JN AF Corron, Ned J. Cooper, Roy M. Blakely, Jonathan N. TI Analytically solvable chaotic oscillator based on a first-order filter SO CHAOS LA English DT Article AB A chaotic hybrid dynamical system is introduced and its analytic solution is derived. The system is described as an unstable first order filter subject to occasional switching of a set point according to a feedback rule. The system qualitatively differs from other recently studied solvable chaotic hybrid systems in that the timing of the switching is regulated by an external clock. The chaotic analytic solution is an optimal waveform for communications in noise when a resistor-capacitor-integrate-and-dump filter is used as a receiver. As such, these results provide evidence in support of a recent conjecture that the optimal communication waveform for any stable infinite-impulse response filter is chaotic. C1 [Corron, Ned J.; Cooper, Roy M.; Blakely, Jonathan N.] US Army RDECOM, Charles M Bowden Lab, Aviat & Missile Res, Ctr Dev & Engn, Redstone Arsenal, AL 35898 USA. RP Corron, NJ (reprint author), US Army RDECOM, Charles M Bowden Lab, Aviat & Missile Res, Ctr Dev & Engn, Redstone Arsenal, AL 35898 USA. NR 23 TC 3 Z9 3 U1 1 U2 1 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 1054-1500 EI 1089-7682 J9 CHAOS JI Chaos PD FEB PY 2016 VL 26 IS 2 AR 023104 DI 10.1063/1.4941376 PG 6 WC Mathematics, Applied; Physics, Mathematical SC Mathematics; Physics GA DF8ID UT WOS:000371600200004 PM 26931585 ER PT J AU Bennett, S Pess, G Bouwes, N Roni, P Bilby, RE Gallagher, S Ruzycki, J Buehrens, T Krueger, K Ehinger, W Anderson, J Jordan, C Bowersox, B Greene, C AF Bennett, Stephen Pess, George Bouwes, Nicolaas Roni, Phil Bilby, Robert E. Gallagher, Sean Ruzycki, Jim Buehrens, Thomas Krueger, Kirk Ehinger, William Anderson, Joseph Jordan, Chris Bowersox, Brett Greene, Correigh TI Progress and Challenges of Testing the Effectiveness of Stream Restoration in the Pacific Northwest Using Intensively Monitored Watersheds SO FISHERIES LA English DT Article ID HABITAT RESTORATION; RIVER RESTORATION; STATISTICAL POWER; COASTAL STREAM; ECOSYSTEM; COLUMBIA; SALMON; MANAGEMENT; STEELHEAD; ABUNDANCE AB Across the Pacific Northwest, at least 17 intensively monitored watershed projects have been implemented to test the effectiveness of a broad range of stream restoration actions for increasing the freshwater production of salmon and steelhead and to better understand fish-habitat relationships. We assess the scope and status of these projects and report on challenges implementing them. We suggest that all intensively monitored watersheds should contain key elements based on sound experimental design concepts and be implemented within an adaptive management framework to maximize learning. The most significant challenges reported by groups were (1) improving coordination between funders, restoration groups, and researchers so that restoration and monitoring actions occur based on the project design and (2) maintaining consistent funding to conduct annual monitoring and evaluation of data. However, we conclude that despite these challenges, the intensively monitored watershed approach is the most reliable means of assessing the efficacy of watershed-scale restoration. C1 [Bennett, Stephen] Utah State Univ, Watershed Sci Dept, 5210 Old Main Hill, Logan, UT 84321 USA. [Pess, George; Jordan, Chris] NOAA, Natl Marine Fisheries Serv, NW Fisheries Sci Ctr, Seattle, WA 98112 USA. [Bouwes, Nicolaas] Eco Log Res Inc, Providence, UT USA. [Roni, Phil] Cramer Fish Sci, Sammamish, WA USA. [Bilby, Robert E.] Weyerhaeuser Co, Federal Way, WA USA. [Gallagher, Sean] Calif Dept Fish & Wildlife, Ft Bragg, CA USA. [Ruzycki, Jim] Oregon Dept Fish & Wildlife, La Grande, OR USA. [Buehrens, Thomas] Washington Dept Fish & Wildlife, Vancouver, WA USA. [Krueger, Kirk; Anderson, Joseph] Washington Dept Fish & Wildlife, Olympia, WA USA. [Ehinger, William] Washington Dept Ecol, Lacey, WA USA. [Bowersox, Brett] Idaho Dept Fish & Game, Lewiston, ID USA. [Greene, Correigh] NOAA, Fisheries Northwest Fisheries Sci Ctr, Seattle, WA USA. RP Bennett, S (reprint author), Utah State Univ, Watershed Sci Dept, 5210 Old Main Hill, Logan, UT 84321 USA. EM bennett.ecological@gmail.com FU National Oceanic and Atmospheric Administration; Integrated Status and Effectiveness Monitoring Program - Bonneville Power Administration Environment Fish and Wildlife [2003-017]; Washington Recreation and Conservation Office; Oregon Watershed Enhancement Board; California Fisheries Restoration Grant Program; Salmon Recovery Funding Board FX We thank Jennifer Bayer and the Pacific Northwest Aquatic Monitoring Partnership for hosting the intensively monitored watershed meeting and providing support for gathering and summarizing the findings. Rebecca Scully provided assistance in coordinating the IMW working group and collating all the online supplements. Martha Jensen updated the IMW location map. Sponsors of IMWs include the National Oceanic and Atmospheric Administration, Integrated Status and Effectiveness Monitoring Program - Bonneville Power Administration Environment Fish and Wildlife (Project #2003-017), Washington Recreation and Conservation Office, Oregon Watershed Enhancement Board, California Fisheries Restoration Grant Program, and Salmon Recovery Funding Board. NR 47 TC 5 Z9 5 U1 11 U2 27 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 0363-2415 EI 1548-8446 J9 FISHERIES JI Fisheries PD FEB 1 PY 2016 VL 41 IS 2 BP 92 EP 103 DI 10.1080/03632415.2015.1127805 PG 12 WC Fisheries SC Fisheries GA DF9FJ UT WOS:000371666100002 ER PT J AU Ivany, CG Hoge, CW AF Ivany, Christopher G. Hoge, Charles W. TI Suicide Attempts in the US Army SO JAMA PSYCHIATRY LA English DT Letter C1 [Ivany, Christopher G.] Off Army Surgeon Gen, 7700 Arlington Blvd, Falls Church, VA 22042 USA. [Hoge, Charles W.] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Ivany, CG (reprint author), Off Army Surgeon Gen, 7700 Arlington Blvd, Falls Church, VA 22042 USA. EM christopher.g.ivany.mil@mail.mil NR 2 TC 0 Z9 0 U1 1 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-622X EI 2168-6238 J9 JAMA PSYCHIAT JI JAMA Psychiatry PD FEB PY 2016 VL 73 IS 2 BP 176 EP 176 DI 10.1001/jamapsychiatry.2015.2363 PG 1 WC Psychiatry SC Psychiatry GA DF8MS UT WOS:000371612500015 PM 26720633 ER PT J AU Coburn, JM Chong, ST Kim, HC Chang, NW Calix, LC Resto, K Lee, DJ Johnson, JL Robbins, RG Klein, TA AF Coburn, Jordan M. Chong, Sung-Tae Kim, Heung-Chul Chang, Nicholas W. Calix, Lesly C. Resto, Karina Lee, Dong-Jin Johnson, Jaree L. Robbins, Richard G. Klein, Terry A. TI Tick surveillance in four southwestern provinces of the Republic of Korea during 2013 SO SYSTEMATIC AND APPLIED ACAROLOGY LA English DT Article DE Haemaphysalis flava; Haemaphysalis longicornis; Ixodes nipponensis; tick surveillance; Korea ID SPOTTED-FEVER GROUP; THROMBOCYTOPENIA SYNDROME VIRUS; HAEMAPHYSALIS-LONGICORNIS TICKS; BORNE ENCEPHALITIS-VIRUS; SOUTH-KOREA; AMBLYOMMA-TESTUDINARIUM; RICKETTSIA-MONACENSIS; EHRLICHIA-CHAFFEENSIS; MOLECULAR-DETECTION; IXODOIDEA-IXODIDAE AB Tick-borne disease surveillance was conducted monthly at different sites in four southwestern provinces of the Republic of Korea (ROK) from April-October 2013. Three general habitats were surveyed: grasses (grasses and herbaceous and crawling vegetation), forests (pine, larch, deciduous, and mixed), and forests+grasses. A total of 27,029 ticks (1,534 adults; 11,755 nymphs; 13,740 larvae) belonging to three genera and five species were collected. Haemaphysalis longicornis (64.76%; 17,504) was the most commonly collected tick, followed by Haemaphysalis flava (29.22%; 7,899), Ixodes nipponensis (5.83%; 1,575), Amblyomma testudinarium (0.17%; 46), and Haemaphysalis phasiana (0.02%; 5). Overall, adult ticks accounted for only 5.68% of all ticks collected, while nymphs and larvae accounted for 43.49% and 50.83%, respectively. Haemaphysalis longicornis nymphs were commonly collected from April-June, followed by increased numbers of adults from June-August, and large numbers of larvae from August-September, while low numbers of all stages were collected during October. Haemaphysalis flava adults and nymphs were commonly collected from April-June and September-October, while large numbers of larvae were collected from July-August. Although fewer I. nipponensis were collected, seasonal developmental stage patterns followed those of H. flava. Similar proportions of males (47.96%) and females (52.04%) of H. flava were collected. However, the proportion of H. longicornis females (85.83%) collected was significantly higher than for males (14.17%), while the proportion of I. nipponensis males (57.62%) was significantly higher than for females (42.38%). Overall, the mean number of ticks collected/hour of collection was highest for forests+grasses (108.54), followed by grasses (97.28) and forests (66.64). C1 [Coburn, Jordan M.; Chang, Nicholas W.; Klein, Terry A.] US Army Publ Hlth Command District Korea Provis, APO, AP 96205 USA. [Coburn, Jordan M.; Chang, Nicholas W.; Klein, Terry A.] 65th Med Brigade, Force Hlth Protect & Prevent Med, Unit 15281, APO, AP 96205 USA. [Chong, Sung-Tae; Kim, Heung-Chul; Johnson, Jaree L.] 65th Med Brigade, Multifunct Med Battal 168, Med Detachment 5, Unit 15247, APO, AP 96205 USA. [Calix, Lesly C.; Johnson, Jaree L.] 65th Med Brigade, Force Hlth Protect & Prevent Med, Unit 15281, APO, AP 96205 USA. [Resto, Karina] 65th Med Brigade, Multifunct Med Battal 168, Unit 15021, APO, AP 96205 USA. [Lee, Dong-Jin] 65th Med Brigade, Multifunct Med Battal 168, Med Detachment 154, Unit 15515, APO, AP 96218 USA. [Robbins, Richard G.] Armed Forces Pest Management Board, Off Assistant Secretary Def Energy Installat & En, Silver Spring, MD 20910 USA. [Coburn, Jordan M.] Carl R Darnall Army Med Ctr, Dept Prevent Med, 76022 Crockett St, Ft Hood, TX 76544 USA. [Chang, Nicholas W.] Madigan Army Med Ctr, Dept Prevent Med, 9911B East Johnson St, Jblm, WA 98327 USA. [Calix, Lesly C.] ARS, Ctr Med Agr & Vet Entomol, 1600 SW 23rd Dr, Gainesville, FL 32608 USA. [Resto, Karina] Joint Culinary Ctr Excellence JCCoE, 1831 Adams Ave,Bldg 4225, Ft Lee, VA 23801 USA. [Lee, Dong-Jin] Korea Univ, Green Campus Bldg,Room 412,5 Ga, Seoul, South Korea. RP Klein, TA (reprint author), 65th Med Brigade, Force Hlth Protect & Prevent Med, Unit 15281, APO, AP 96205 USA. EM terry.a.klein2.civ@mail.mil FU Armed Forces Health Surveillance Center-Global Emerging Infections Surveillance and Response System (AFHSC-GEIS), Silver Spring, MD; 65th Medical Brigade, Yongsan U.S. Army Garrison, Seoul, Korea; Public Health Command Region-Pacific, Camp Zama, Japan FX Funding for this work was provided by the Armed Forces Health Surveillance Center-Global Emerging Infections Surveillance and Response System (AFHSC-GEIS), Silver Spring, MD, the 65th Medical Brigade, Yongsan U.S. Army Garrison, Seoul, Korea, and the Public Health Command Region-Pacific, Camp Zama, Japan. NR 54 TC 2 Z9 2 U1 0 U2 0 PU SYSTEMATIC & APPLIED ACAROLOGY SOC LONDON, NATURAL HISTORY MUSEUM PI LONDON PA DEPT ENTOMOLOGY, LONDON, SW7 5BD, ENGLAND SN 1362-1971 J9 SYST APPL ACAROL-UK JI Syst. Appl. Acarol. PD FEB PY 2016 VL 21 IS 2 BP 147 EP 165 PG 19 WC Entomology SC Entomology GA DF6XY UT WOS:000371502700001 ER PT J AU Beske, PH Bradford, AB Grynovicki, JO Glotfelty, EJ Hoffman, KM Hubbard, KS Tuznik, KM McNutt, PM AF Beske, Phillip H. Bradford, Aaron B. Grynovicki, Justin O. Glotfelty, Elliot J. Hoffman, Katie M. Hubbard, Kyle S. Tuznik, Kaylie M. McNutt, Patrick M. TI Botulinum and Tetanus Neurotoxin-Induced Blockade of Synaptic Transmission in Networked Cultures of Human and Rodent Neurons SO TOXICOLOGICAL SCIENCES LA English DT Article DE neurons; botulinum toxins; tetanus toxin; synaptic transmission; electrophysiology; spontaneous postsynaptic currents ID TOXIN TYPE-A; IN-VIVO; MOLECULAR-MECHANISMS; HIPPOCAMPAL-NEURONS; CELL-CULTURE; STEM-CELLS; SYNAPSES; RELEASE; ASSAY; IDENTIFICATION AB Clinical manifestations of tetanus and botulism result from an intricate series of interactions between clostridial neurotoxins (CNTs) and nerve terminal proteins that ultimately cause proteolytic cleavage of SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) proteins and functional blockade of neurotransmitter release. Although detection of cleaved SNARE proteins is routinely used as a molecular readout of CNT intoxication in cultured cells, impaired synaptic function is the pathophysiological basis of clinical disease. Work in our laboratory has suggested that the blockade of synaptic neurotransmission in networked neuron cultures offers a phenotypic readout of CNT intoxication that more closely replicates the functional endpoint of clinical disease. Here, we explore the value of measuring spontaneous neurotransmission frequencies as novel and functionally relevant readouts of CNT intoxication. The generalizability of this approach was confirmed in primary neuron cultures as well as human and mouse stem cell-derived neurons exposed to botulinumneurotoxin serotypes A-G and tetanus neurotoxin. The sensitivity and specificity of synaptic activity as a reporter of intoxication was evaluated in assays representing the principal clinical and research purposes of in vivo studies. Our findings confirm that synaptic activity offers a novel and functionally relevant readout for the in vitro characterizations of CNTs. They further suggest that the analysis of synaptic activity in neuronal cell cultures can serve as a surrogate for neuromuscular paralysis in the mouse lethal assay, and therefore is expected to significantly reduce the need for terminal animal use in toxin studies and facilitate identification of candidate therapeutics in cell-based screening assays. C1 [Beske, Phillip H.; Bradford, Aaron B.; Grynovicki, Justin O.; Glotfelty, Elliot J.; Hoffman, Katie M.; Hubbard, Kyle S.; Tuznik, Kaylie M.; McNutt, Patrick M.] US Army, Med Res Inst Chem Def, Div Res, Cellular & Mol Biol Branch, Aberdeen Proving Ground, MD USA. RP McNutt, PM (reprint author), US Army, Med Res Inst Chem Def, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM patrick.m.mcnutt2.civ@mail.mil FU Defense Threat Reduction Agency - Joint Science and Technology Office, Medical ST Division [CBM.THRTOX.01.10.RC.021]; National Institute of Allergy and Infectious Diseases [IAA AOD12058-0001-0000, R01 5R01AI093504]; Defense Threat Reduction Agency-National Research Council; National Research Council; Oak Ridge Institute of Science and Engineering FX This work was conducted under funding from the Defense Threat Reduction Agency - Joint Science and Technology Office, Medical S&T Division (grant number CBM.THRTOX.01.10.RC.021); National Institute of Allergy and Infectious Diseases (IAA AOD12058-0001-0000 and R01 5R01AI093504). This research was performed while P.B. held a Defense Threat Reduction Agency-National Research Council Research Associateship award; K.H. held a National Research Council Research Associateship award; and J.O., A.B., E.G., K.M., and K.T. held Oak Ridge Institute of Science and Engineering Fellowship awards. NR 53 TC 3 Z9 3 U1 2 U2 6 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1096-6080 EI 1096-0929 J9 TOXICOL SCI JI Toxicol. Sci. PD FEB PY 2016 VL 149 IS 2 BP 503 EP 515 DI 10.1093/toxsci/kfv254 PG 13 WC Toxicology SC Toxicology GA DF8NF UT WOS:000371613900023 PM 26615023 ER PT J AU Alam, R Labine, M Karwacki, CJ Kamat, PV AF Alam, Rabeka Labine, Molly Karwacki, Christopher J. Kamat, Prashant V. TI Modulation of Cu2-xS Nanocrystal Plasmon Resonance through Reversible Photoinduced Electron Transfer SO ACS NANO LA English DT Article DE plasmon resonance; copper sulfide; semiconductor nanocrystals; electron transfer; methyl viologen ID COPPER SULFIDE NANOCRYSTALS; SEMICONDUCTOR NANOCRYSTALS; SELENIDE NANOCRYSTALS; PHOTOTHERMAL THERAPY; QUANTUM DOTS; SIZE; SHAPE; NANOPARTICLES; RELAXATION; DYNAMICS AB Copper sulfide (Cu2-xS) nanocrystals with nonstoichiometric composition exhibit plasmon resonance in the near -infrared region. Compositional changes and varying electron density markedly affect the position and intensity of the plasmon resonance. We report a photo chemically induced" phenomenon of modulating the plasmon resonance in a controlled fashion. As photo generated reduced methyl viologen radicals transfer electrons to Cu2-xS in inert solutions, " we observe a decrease in localized surface plasmon resonance (LSPR) absorbance at 1160 nm. Upon exposure to air, the plasmon resonance band recovers as stored electrons are scavenged away by oxygen. This cycle of electron charge and discharge of Cu2-xS nanocrystals is reversible and can be repeated through photoirradiation in N-2 saturated solution followed by exposure of the suspension to air. The spectroscopic studies that provide mechanistic insights into the reversible charging and discharging of plasmonic Cu2-xS are discussed. C1 [Alam, Rabeka; Labine, Molly; Kamat, Prashant V.] Univ Notre Dame, Radiat Lab, Notre Dame, IN 46556 USA. [Alam, Rabeka; Labine, Molly; Kamat, Prashant V.] Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA. [Karwacki, Christopher J.] US Army, Edgewood Chem Biol Ctr, Res Dev & Engn Command, 5183 Blackhawk Rd, Aberdeen, MD 21010 USA. [Labine, Molly] Univ Guelph, Guelph, ON N1G 2W1, Canada. RP Kamat, PV (reprint author), Univ Notre Dame, Radiat Lab, Notre Dame, IN 46556 USA.; Kamat, PV (reprint author), Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA. EM pkamat@nd.edu FU Sustainable Energy Initiative (SEI) funds MCF part of the Center for Sustainable Energy at Notre Dame (ND Energy); ARO [64011-CH]; Division of Chemical Sciences, Geosciences, and Biosciences, Office of Basic Energy Sciences of the U.S. Department of Energy [DE-FC02-04ER15533] FX We would like to acknowledge Steven Kobosko and Ian Lightcap for help with XPS data collection and analysis. We thank the ND Energy Materials Characterization Facility (MCF) for the use of the UV visible Near-IR spectrometer, XPS, and TGA. The Sustainable Energy Initiative (SEI) funds MCF, which is part of the Center for Sustainable Energy at Notre Dame (ND Energy). We also thank Notre Dame Integrated Imaging Facility (NDIIF) for electron microscopy facilities. P.V.K. and R.A. thank the Army Research Office for the support through the award ARO 64011-CH. P.V.K. and M.L. also acknowledge the support by the Division of Chemical Sciences, Geosciences, and Biosciences, Office of Basic Energy Sciences of the U.S. Department of Energy through award DE-FC02-04ER15533. This is a document number 5099 from the Notre Dame Radiation Laboratory. NR 38 TC 3 Z9 3 U1 23 U2 53 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1936-0851 EI 1936-086X J9 ACS NANO JI ACS Nano PD FEB PY 2016 VL 10 IS 2 BP 2880 EP 2886 DI 10.1021/acsnano.5b08066 PG 7 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA DE9VL UT WOS:000370987400133 PM 26853633 ER PT J AU Wood, AW Hopson, T Newman, A Brekke, L Arnold, J Clark, M AF Wood, Andrew W. Hopson, Tom Newman, Andy Brekke, Levi Arnold, Jeff Clark, Martyn TI Quantifying Streamflow Forecast Skill Elasticity to Initial Condition and Climate Prediction Skill SO JOURNAL OF HYDROMETEOROLOGY LA English DT Article ID SOIL-MOISTURE; UNITED-STATES; RIVER-BASIN; PREDICTABILITY; MODELS; RUNOFF; ERRORS; SNOW AB Water resources management decisions commonly depend on monthly to seasonal streamflow forecasts, among other kinds of information. The skill of such predictions derives from the ability to estimate a watershed's initial moisture and energy conditions and to forecast future weather and climate. These sources of predictability are investigated in an idealized (i.e., perfect model) experiment using calibrated hydrologic simulation models for 424 watersheds that span the continental United States. Prior work in this area also followed an ensemble-based strategy for attributing streamflow forecast uncertainty, but focused only on two end points representing zero and perfect information about future forcings and initial conditions. This study extends the prior approach to characterize the influence of varying levels of uncertainty in each area on streamflow prediction uncertainty. The sensitivities enable the calculation of flow forecast skill elasticities (i.e., derivatives) relative to skill in either predictability source, which are used to characterize the regional, seasonal, and predictand variations in flow forecast skill dependencies. The resulting analysis provides insights on the relative benefits of investments toward improving watershed monitoring (through modeling and measurement) versus improved climate forecasting. Among other key findings, the results suggest that climate forecast skill improvements can be amplified in streamflow prediction skill, which means that climate forecasts may have greater benefit for monthly-to-seasonal flow forecasting than is apparent from climate forecast skill considerations alone. The results also underscore the importance of advancing hydrologic modeling, expanding watershed observations, and leveraging data assimilation, all of which help capture initial hydrologic conditions that are often the dominant influence on hydrologic predictions. C1 [Wood, Andrew W.; Hopson, Tom; Newman, Andy; Clark, Martyn] NCAR, Res Applicat Lab, POB 3000, Boulder, CO 80307 USA. [Brekke, Levi] US Bur Reclamat, Off Res & Dev, Denver, CO 80225 USA. [Arnold, Jeff] US Army, Corps Engineers, Inst Water Resources, Seattle, WA USA. RP Wood, AW (reprint author), NCAR, Res Applicat Lab, POB 3000, Boulder, CO 80307 USA. EM andywood@ucar.edu FU Bureau of Reclamation; U.S. Army Corps of Engineers; National Science Foundation FX The research and analysis reported herein were supported by the Bureau of Reclamation and the U.S. Army Corps of Engineers. We would like to acknowledge high-performance computing support from Yellowstone (ark:/85065/d7wd3xhc) provided by NCAR's Computational and Information Systems Laboratory, sponsored by the National Science Foundation. We also thank two anonymous reviewers for critical and constructive comments that have substantially enhanced the clarity and readability of the paper. NR 40 TC 4 Z9 4 U1 3 U2 13 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 1525-755X EI 1525-7541 J9 J HYDROMETEOROL JI J. Hydrometeorol. PD FEB PY 2016 VL 17 IS 2 BP 651 EP 668 DI 10.1175/JHM-D-14-0213.1 PG 18 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA DF8NH UT WOS:000371614100001 ER PT J AU Mondello, S Xanthopoulos, P Korenkevych, D Czeiter, E Tortella, F Hayes, R Barzo, P Pardalos, P Buki, A AF Mondello, S. Xanthopoulos, P. Korenkevych, D. Czeiter, E. Tortella, F. Hayes, R. Barzo, P. Pardalos, P. Buki, A. TI MULTIMODAL MONITORING AND OUTCOME PREDICTION AFTER TRAUMATIC BRAIN INJURY USING SUPPORT VECTOR MACHINES SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 12th Symposium of the International-Neurotrauma-Society CY FEB 01-04, 2016 CL Cape Town, SOUTH AFRICA SP Int Neurotrauma Soc C1 [Mondello, S.] Univ Messina, I-98100 Messina, Italy. [Xanthopoulos, P.; Korenkevych, D.; Pardalos, P.] Univ Florida, Gainesville, FL 32611 USA. [Czeiter, E.; Buki, A.] Univ Pecs, Pecs, Hungary. [Tortella, F.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Hayes, R.] Banyan Biomarkers Inc, Alachua, FL USA. [Barzo, P.] Univ Szeged, Szeged, Hungary. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD FEB 1 PY 2016 VL 33 IS 3 MA 78 BP A13 EP A14 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA DC9AV UT WOS:000369513600038 ER PT J AU Mondello, S Shear, D Bramlett, H Dixon, C Schmid, K Dietrich, W Wang, K Hayes, R Glushakova, O Povlishock, J Tortella, F Kochanek, P AF Mondello, S. Shear, D. Bramlett, H. Dixon, C. Schmid, K. Dietrich, W. Wang, K. Hayes, R. Glushakova, O. Povlishock, J. Tortella, F. Kochanek, P. TI THE POTENTIAL UTILITY OF BRAIN INJURY BIOMARKER IN PRE-CLINICAL DRUG SCREENING BY OPERATION BRAIN TRAUMA THERAPY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 12th Symposium of the International-Neurotrauma-Society CY FEB 01-04, 2016 CL Cape Town, SOUTH AFRICA SP Int Neurotrauma Soc C1 [Mondello, S.] Univ Messina, I-98100 Messina, Italy. [Shear, D.; Schmid, K.; Tortella, F.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Bramlett, H.] Univ Miami, Miller Sch Med, Coral Gables, FL 33124 USA. [Dixon, C.; Kochanek, P.] Univ Pittsburgh, Pittsburgh, PA 15260 USA. [Dietrich, W.] Univ Miami, Coral Gables, FL 33124 USA. [Wang, K.] Univ Florida, Gainesville, FL 32611 USA. [Hayes, R.; Glushakova, O.] Banyan Biomarkers Inc, Alachua, FL USA. [Povlishock, J.] Virginia Commonwealth Univ, Richmond, VA 23284 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD FEB 1 PY 2016 VL 33 IS 3 MA 77 BP A13 EP A13 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA DC9AV UT WOS:000369513600037 ER PT J AU Zuber, S AF Zuber, Stephan TI High-energy Computed Tomographic Inspection of Munitions SO MATERIALS EVALUATION LA English DT Article DE radiography; high energy; computed tomography; munitions; nondestructive testing; NDT; computed tomography AB This is a technical overview showing the application of using advanced computed tomography for the inspection of munitions and weapons systems. Although computed tomography cannot produce full-rate production throughput, the quality assurance it can provide on research and development components, reverse engineering, and malfunction investigations is unmatched. Using computed tomography within the Department of Defense is highly beneficial to ensure the end products function correctly and are effective. C1 [Zuber, Stephan] US Army, Armament Res Dev & Engn Ctr, ASNT NDT Level 3, Radiog Lab,Qual Engn & Syst Assurance Directorate, Picatinny Arsenal, NJ 07806 USA. RP Zuber, S (reprint author), US Army, Armament Res Dev & Engn Ctr, ASNT NDT Level 3, Radiog Lab,Qual Engn & Syst Assurance Directorate, Picatinny Arsenal, NJ 07806 USA. EM stephan.c.zuber.civ@mail.mil NR 5 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC NONDESTRUCTIVE TEST PI COLUMBUS PA 1711 ARLINGATE LANE PO BOX 28518, COLUMBUS, OH 43228-0518 USA SN 0025-5327 J9 MATER EVAL JI Mater. Eval. PD FEB PY 2016 VL 74 IS 2 BP 194 EP 202 PG 9 WC Materials Science, Characterization & Testing SC Materials Science GA DD8WI UT WOS:000370207200005 ER PT J AU Sun, J Choi, KK AF Sun, Jason Choi, Kwong-Kit TI Fabrication of resonator-quantum well infrared photodetector focal plane array by inductively coupled plasma etching SO OPTICAL ENGINEERING LA English DT Article DE inductively coupled plasma etching; resonator-quantum well infrared photodetectors; focal plane array; GaAs substrate; removal ID GAAS; DAMAGE AB Inductively coupled plasma (ICP) etching has distinct advantages over reactive ion etching in that the etching rates are considerably higher, the uniformity is much better, and the sidewalls of the etched material are highly anisotropic due to the higher plasma density and lower operating pressure. Therefore, ICP etching is a promising process for pattern transfer required during microelectronic and optoelectronic fabrication. Resonator-quantum well infrared photodetectors (R-QWIPs) are the next generation of QWIP detectors that use resonances to increase the quantum efficiency (QE). To fabricate R- QWIP focal plane arrays (FPAs), two optimized ICP etching processes are developed. Using these etching techniques, we have fabricated R- QWIP FPAs of several different formats and pixel sizes with the required dimensions and completely removed the substrates of the FPAs. Their QE spectra were tested to be 30 to 40%. The operability and spectral non-uniformity of the FPA is similar to 99.5 and 3%, respectively. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License C1 [Sun, Jason; Choi, Kwong-Kit] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RP Sun, J (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM jason.sun@arl.army.mil NR 12 TC 0 Z9 0 U1 4 U2 13 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 EI 1560-2303 J9 OPT ENG JI Opt. Eng. PD FEB PY 2016 VL 55 IS 2 AR 026119 DI 10.1117/1.OE.55.2.026119 PG 5 WC Optics SC Optics GA DF3YD UT WOS:000371283600042 ER PT J AU Lloyd, JT Becker, R AF Lloyd, J. T. Becker, R. TI Stress-based crystal analysis of yielding in rolled Mg AZ31B SO PHILOSOPHICAL MAGAZINE LA English DT Article DE micromechanics; Magnesium; twinning; crystal plasticity; yield surface; polycrystal ID MAGNESIUM ALLOY AZ31B; CRYSTALLOGRAPHIC TEXTURE; PURE MAGNESIUM; MECHANICAL-BEHAVIOR; PLASTIC ANISOTROPY; DEFORMATION; EVOLUTION; STRAIN; MODEL; METALS AB A stress-based analysis is demonstrated that can be used to evaluate the effect of material orientation and loading conditions on the micro- and macro-scale yield response of strongly textured metals. This analysis is used to construct microscale yield surfaces for selected deformation mechanisms in rolled AZ31B. Two-dimensional projections of these surfaces are plotted along sample directions to quantify the relative activity of each mechanism for various loading conditions. By assigning each mechanism realistic strengths, the analysis is used to quantify the influence of each deformation mechanism on macroscale yield behaviour. Due to its simplicity, this analysis can be easily carried out to probe and visualize projections of material response in any part of stress space given the material's texture, its relevant deformation mechanisms and realistic initial strengths of these mechanisms. C1 [Lloyd, J. T.; Becker, R.] US Army, Res Lab, RDRL WMP C, Impact Phys Branch, Aberdeen, MD USA. RP Lloyd, JT (reprint author), US Army, Res Lab, RDRL WMP C, Impact Phys Branch, Aberdeen, MD USA. EM jeffrey.t.lloyd.civ@mail.mil NR 39 TC 2 Z9 2 U1 3 U2 7 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1478-6435 EI 1478-6443 J9 PHILOS MAG JI Philos. Mag. PD FEB 1 PY 2016 VL 96 IS 4 BP 370 EP 386 DI 10.1080/14786435.2015.1132854 PG 17 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering; Physics, Applied; Physics, Condensed Matter SC Materials Science; Metallurgy & Metallurgical Engineering; Physics GA DE5DJ UT WOS:000370650900004 ER PT J AU Mueller, CJ Cannella, WJ Bays, JT Bruno, TJ DeFabio, K Dettman, HD Gieleciak, RM Huber, ML Kweon, CB McConnell, SS Pitz, WJ Ratcliff, MA AF Mueller, Charles J. Cannella, William J. Bays, J. Timothy Bruno, Thomas J. DeFabio, Kathy Dettman, Heather D. Gieleciak, Rafal M. Huber, Marcia L. Kweon, Chol-Bum McConnell, Steven S. Pitz, William J. Ratcliff, Matthew A. TI Diesel Surrogate Fuels for Engine Testing and Chemical-Kinetic Modeling: Compositions and Properties SO ENERGY & FUELS LA English DT Article ID DISTILLATION CURVE APPROACH; THERMOPHYSICAL PROPERTIES; TRANSPORTATION FUELS; CETANE NUMBER; N-HEXADECANE; SHOCK-TUBE; COMBUSTION; MECHANISM; IGNITION; 1,3,5-TRIISOPROPYLCYCLOHEXANE AB The primary objectives of this work were to formulate, blend, and characterize a set of four ultralow-sulfur diesel surrogate fuels in quantities sufficient to enable their study in single-cylinder-engine and combustion-vessel experiments. The surrogate fuels feature increasing levels of compositional accuracy (i.e., increasing exactness in matching hydrocarbon structural characteristics) relative to the single target diesel fuel upon which the surrogate fuels are based. This approach was taken to assist in determining the minimum level of surrogate-fuel compositional accuracy that is required to adequately emulate the performance characteristics of the target fuel under different combustion modes. For each of the four surrogate fuels, an approximately 30 L batch was blended, and a number of the physical aid chemical properties were measured. This work documents the surrogate-fuel creation process= and the results of the property measurements. C1 [Mueller, Charles J.] Sandia Natl Labs, 7011 East Ave,MS 9053, Livermore, CA 94550 USA. [Cannella, William J.; DeFabio, Kathy] Chevron Energy Technol Co, 100 Chevron Way, Richmond, CA 94801 USA. [Bays, J. Timothy] Pacific NW Natl Lab, 902 Battelle Blvd, Richland, WA 99352 USA. [Bruno, Thomas J.; Huber, Marcia L.] Natl Inst Stand & Technol, 325 Broadway, Boulder, CO 80305 USA. [Dettman, Heather D.; Gieleciak, Rafal M.] Nat Resources Canada CanmetENERGY, 1 Oil Patch Dr, Devon, AB T9G 1A8, Canada. [Kweon, Chol-Bum] US Army Res Lab, 4603 Flare Loop Rd, Aberdeen Proving Ground, MD 21005 USA. [McConnell, Steven S.] Marathon Petr Co, 539 South Main St, Findlay, OH 45840 USA. [Pitz, William J.] Lawrence Livermore Natl Lab, 7000 East Ave, Livermore, CA 94550 USA. [Ratcliff, Matthew A.] Natl Renewable Energy Lab, 15013 Denver West Pkwy, Golden, CO 80401 USA. RP Mueller, CJ (reprint author), Sandia Natl Labs, 7011 East Ave,MS 9053, Livermore, CA 94550 USA. EM cjmuell@sandia.gov RI Kweon, Chol-Bum/G-5425-2016 FU U.S. Department of Energy (U.S. DOE) Office of Vehicle Technologies; Coordinating Research Council (CRC); CRC; Natural Resources Canada; Canadian federal government interdepartmental Program of Energy Research and Development (PERD); ecoENERGY Innovation Initiative (ecoEII); U.S. Army Research Laboratory; U.S. Department of Energy [DE-AC04-94AL85000]; Chevron Energy Technology Co., a division of Chevron USA, Richmond, CA, USA; U.S. DOE [DE-AC05-76RL01830, DE-AC52-07NA27344]; U.S. DOE, Vehicle Technologies Office; Alliance for Sustainable Energy, LLC [DE347AC36-99GO10337] FX Funding for this research was provided by the U.S. Department of Energy (U.S. DOE) Office of Vehicle Technologies, the Coordinating Research Council (CRC) and the companies that employ the CRC members, Natural Resources Canada and the Canadian federal government interdepartmental Program of Energy Research and Development (PERD) and ecoENERGY Innovation Initiative (ecoEII), and the U.S. Army Research Laboratory. The study was conducted under the auspices of CRC. We thank U.S. DOE program managers Kevin Stork and Gurpreet Singh for supporting the participation of the U.S. national laboratories in this study. C.J.M's portion of the research was conducted at the Combustion Research Facility, Sandia National Laboratories, Livermore, CA, USA. Sandia is a multiprogram laboratory operated by Sandia Corp., a Lockheed Martin company, for the U.S. Department of Energy's National Nuclear Security Administration under Contract DE-AC04-94AL85000. W.J.C's portion of the research was funded by and conducted at Chevron Energy Technology Co., a division of Chevron USA, Richmond, CA, USA. J.T.B's portion of the research was conducted at Pacific Northwest National Laboratory, a multiprogram laboratory operated by the Battelle Memorial Institute under Contract No. DE-AC05-76RL01830 for the U.S. DOE. J.T.B. also thanks Drs. John Linehan, Molly O'Hagan, and Suh-Jane Lee, Mr. Gregory Coffey, Ms. Margaret Jones, Ms. Tricia Smurthwaite, and Ms. Diana Tran for their discussions and assistance in obtaining data critical to this work. W.J.P's portion of the research was performed under the auspices of the U.S. DOE by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344. M.A.R's portion of the research was conducted at the National Renewable Energy Laboratory, Golden, CO, USA, with support from the U.S. DOE, Vehicle Technologies Office. NREL is operated by the Alliance for Sustainable Energy, LLC under Contract No. DE347AC36-99GO10337. M.A.R. thanks NREL colleagues Jon Luecke, Earl Christensen, Gina Chupka, and Lisa Fouts for their excellent technical contributions to this work. Finally, helpful input and guidance from Kenneth D. Rose, formerly of ExxonMobil, are gratefully acknowledged. NR 82 TC 12 Z9 12 U1 8 U2 22 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0887-0624 EI 1520-5029 J9 ENERG FUEL JI Energy Fuels PD FEB PY 2016 VL 30 IS 2 BP 1445 EP 1461 DI 10.1021/acs.energyfuels.5b02879 PG 17 WC Energy & Fuels; Engineering, Chemical SC Energy & Fuels; Engineering GA DE5NZ UT WOS:000370679000075 PM 27330248 ER PT J AU Maley, JM AF Maley, James M. TI Efficient Attitude Estimation for a Spin-Stabilized Projectile SO JOURNAL OF GUIDANCE CONTROL AND DYNAMICS LA English DT Article ID FLIGHT AB An algorithm using an extended Kalman filter is presented for estimating the full attitude of a nose-controlled spin-stabilized projectile using magnetometers and a velocity vector estimate with increased computational efficiency. A dynamic model based on the projectile equations of motion is used in the predictor step of the Kalman filter. A new coordinate system is introduced that enables both the process and measurement models of the Kalman filter to be described by linear, slowly time-varying systems. This property is exploited to generate a steady-state Kalman filter which per current knowledge, has never been done for this problem. Both the extended Kalman filter and steady-state Kalman filter are shown to perform well in simulation studies, and the difference in performance between the two filters is very small. C1 [Maley, James M.] US Army, Res Lab, Guidance Technol Branch, Aberdeen Proving Ground, MD 21005 USA. RP Maley, JM (reprint author), US Army, Res Lab, Guidance Technol Branch, Aberdeen Proving Ground, MD 21005 USA. FU Armament Research, Development, and Engineering Center FX The author gratefully acknowledges the sponsorship of the Project Manager for Combat Ammunition Systems and the technical contributions (including providing the flight system simulation) of the Armament Research, Development, and Engineering Center. The author also would like to thank Luisa Fairfax and Frank Fresconi for their comments and insight, as well as Frank Fresconi for providing a detailed technical review of this document. NR 14 TC 1 Z9 1 U1 2 U2 8 PU AMER INST AERONAUTICS ASTRONAUTICS PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0731-5090 EI 1533-3884 J9 J GUID CONTROL DYNAM JI J. Guid. Control Dyn. PD FEB PY 2016 VL 39 IS 2 BP 339 EP 350 DI 10.2514/1.G001104 PG 12 WC Engineering, Aerospace; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA DE7ZR UT WOS:000370856100011 ER PT J AU Bradford, JC Lukos, JR Ferris, DP AF Bradford, J. Cortney Lukos, Jamie R. Ferris, Daniel P. TI Electrocortical activity distinguishes between uphill and level walking in humans SO JOURNAL OF NEUROPHYSIOLOGY LA English DT Article DE locomotion; EEG; mobile brain imaging; motor control; independent component analysis ID INDEPENDENT COMPONENT ANALYSIS; VISUALLY GUIDED LOCOMOTION; POSTERIOR PARIETAL CORTEX; CENTRAL PATTERN GENERATOR; SOLEUS-H-REFLEX; TREADMILL WALKING; SLOPED SURFACES; WORKING-MEMORY; MOTOR CORTEX; GAMMA-RANGE AB The objective of this study was to determine if electrocortical activity is different between walking on an incline compared with level surface. Subjects walked on a treadmill at 0% and 15% grades for 30 min while we recorded electroencephalography (EEG). We used independent component (IC) analysis to parse EEG signals into maximally independent sources and then computed dipole estimations for each IC. We clustered cortical source ICs and analyzed event-related spectral perturbations synchronized to gait events. Theta power fluctuated across the gait cycle for both conditions, but was greater during incline walking in the anterior cingulate, sensorimotor and posterior parietal clusters. We found greater gamma power during level walking in the left sensorimotor and anterior cingulate clusters. We also found distinct alpha and beta fluctuations, depending on the phase of the gait cycle for the left and right sensorimotor cortices, indicating cortical lateralization for both walking conditions. We validated the results by isolating movement artifact. We found that the frequency activation patterns of the artifact were different than the actual EEG data, providing evidence that the differences between walking conditions were cortically driven rather than a residual artifact of the experiment. These findings suggest that the locomotor pattern adjustments necessary to walk on an incline compared with level surface may require supraspinal input, especially from the left sensorimotor cortex, anterior cingulate, and posterior parietal areas. These results are a promising step toward the use of EEG as a feed-forward control signal for ambulatory brain-computer interface technologies. C1 [Bradford, J. Cortney] US Army Res Lab, Translat Neurosci Branch, Aberdeen Proving Ground, MD USA. [Lukos, Jamie R.] Pacific, Appl Res & Adv Concepts Branch, Space & Naval Warfare Syst Ctr SPAWAR, San Diego, CA USA. [Bradford, J. Cortney; Ferris, Daniel P.] Univ Michigan, Sch Kinesiol, Ann Arbor, MI 48109 USA. RP Bradford, JC (reprint author), 459 Mulberry Point Rd, Aberdeen Proving Ground, MD 21005 USA. EM jcbrad@umich.edu FU Army Research Laboratory FX Research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement nos. WN911NF-10-2-0022 (Cognitive and Neuroergonomics Collaborative Technology Alliance) and WN911NF-10-2-0019 (Oak Ridge Associated Universities). NR 64 TC 1 Z9 1 U1 1 U2 6 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-3077 EI 1522-1598 J9 J NEUROPHYSIOL JI J. Neurophysiol. PD FEB 1 PY 2016 VL 115 IS 2 BP 958 EP 966 DI 10.1152/jn.00089.2015 PG 9 WC Neurosciences; Physiology SC Neurosciences & Neurology; Physiology GA DF2EW UT WOS:000371154800031 PM 26683062 ER PT J AU Kauvar, DS Martin, ED Givens, MD AF Kauvar, David S. Martin, Eric D. Givens, Matthew D. TI Thirty-Day Outcomes after Elective Percutaneous or Open Endovascular Repair of Abdominal Aortic Aneurysms SO ANNALS OF VASCULAR SURGERY LA English DT Article ID QUALITY IMPROVEMENT PROGRAM; PRECLOSE TECHNIQUE; ACCESS; EXPERIENCE; SUCCESS AB Background: Percutaneous endovascular aneurysm repair (PEVAR) has become accepted as a suitable alternative to open EVAR (OEVAR) in the treatment of abdominal aortic aneurysms (AAAs). Direct comparisons between the 2 techniques have been infrequently reported and have predominantly focused on immediate procedural outcomes. The objective of this study was to compare contemporary 30-day postoperative outcomes between successfully completed elective PEVAR and OEVAR. Methods: The 2012 National Surgical Quality Improvement Program database was queried for all elective primary AAA repairs. Procedures on ruptured AAAs and those involving adjunctive thoracic, abdominal, or extremity procedures were excluded. Cases completed with at least one surgical exposure of the femoral artery for access (OPEN) were compared with those completed without such exposure (PERC). Preoperative, intraoperative, and 30-day postoperative variables were compared using appropriate univariate statistical tests. A P value of <= 0.05 was considered significant for all comparisons. Results: A total of 1,589 (51%) OPEN and 1,533 (49%) PERC cases met inclusion and exclusion criteria. Preoperative characteristics did not differ between groups. OPEN cases took significantly longer (150 +/- 69 min) than PERC cases (134 +/- 65 min, P < 0.001). No significant differences were found between the groups in any postoperative occurrence, but the rate of venous thromboembolism twice as high in OPEN (16, 1.0%) than PERC cases (7, 0.5%, P = 0.07). In addition, wound complications (36, 2.3% OPEN vs. 23, 1.3% PERC, P = 0.11) were more common in OPEN cases but were diagnosed a week sooner on average in PERC cases (19 days OPEN and 12 days PERC). Median postoperative length of stay was 2 days among OPEN cases versus 1 day in PERC cases (P = 0.11). Female gender and obesity predicted wound complications in the OPEN group but not in the PERC group. Conclusions: Successfully completed PEVAR and OEVAR have similar rates of overall complications. Female gender and obesity predict wound complications in OEVAR but not in PEVAR, which appears to be a safe alternative to OEVAR. PEVAR has the advantage of shorter operative time and the potential for a shorter postoperative stay, and may offer the advantage of fewer wound complications in females and obese patients. C1 [Kauvar, David S.; Martin, Eric D.] Dwight D Eisenhower Army Med Ctr, Dept Surg, Ft Gordon, GA USA. [Kauvar, David S.] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. [Givens, Matthew D.] Dwight D Eisenhower Army Med Ctr, Dept Radiol, Ft Gordon, GA USA. RP Kauvar, DS (reprint author), DDEAMC, Dept Surg, 300 Hosp Dr, Ft Gordon, GA 30905 USA. EM davekauvar@gmail.com NR 16 TC 2 Z9 3 U1 1 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0890-5096 EI 1615-5947 J9 ANN VASC SURG JI Ann. Vasc. Surg. PD FEB PY 2016 VL 31 BP 46 EP 51 DI 10.1016/j.avsg.2015.10.009 PG 6 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA DD8XX UT WOS:000370211300007 PM 26658092 ER PT J AU Nyland, JE Alexander, DN Grigson, PS AF Nyland, Jennifer E. Alexander, Danielle N. Grigson, Patricia S. TI Drug-Motivated Behavior in Rats With Lesions of the Thalamic Orosensory Area SO BEHAVIORAL NEUROSCIENCE LA English DT Article DE trigeminal orosensory area; thalamus; motivated behavior; morphine; cocaine ID PHYSICAL-DEPENDENCE LIABILITY; CONDITIONED PLACE PREFERENCE; PAIRED TASTE CUE; LITHIUM-CHLORIDE; SACCHARIN INTAKE; ANTICIPATORY CONTRAST; INDUCED SUPPRESSION; GUSTATORY THALAMUS; CORN-OIL; EXCITOTOXIC LESIONS AB Rats suppress intake of a palatable taste cue when paired with a rewarding or an aversive stimulus in appetitive or aversive conditioning, respectively. A similar phenomenon occurs with drugs of abuse, but the nature of this conditioning has been subject for debate. While relatively little is known about the underlying neural circuitry, we recently reported bilateral lesions of the thalamic trigeminal orosensory area isolate drug-induced suppression of intake of a taste cue. The lesion blocks avoidance of the taste cue when paired with experimenter delivered drugs of abuse, yet has no effect on avoidance of the same cue when paired with an aversive agent or when it predicts access to a highly palatable sucrose solution. We hypothesize the lesion may blunt the rewarding properties of the drug. To test this, we used a runway apparatus, as running speed has been shown to increase with increasing reward value. Our hypothesis was supported by failure of the lesioned rats to increase running speed for morphine. Interestingly, lesioned rats did avoid intake of the drug-paired cue when presented in the runway apparatus and displayed naloxone-precipitated withdrawal. Using a partial crossover design, the lesion prevented avoidance of a cocaine-paired cue when presented in the home cage. We conclude that the lesion disrupts avoidance of a taste cue in anticipation of the rewarding properties of a drug but, at least in the presence of contextual cues, allows for avoidance of a taste cue as it elicits the onset of an aversive conditioned state of withdrawal. C1 [Nyland, Jennifer E.; Alexander, Danielle N.; Grigson, Patricia S.] Penn State Univ, Dept Neural & Behav Sci, University Pk, PA 16802 USA. RP Nyland, JE (reprint author), US Army, Battlefield Pain Management, Inst Surg Res, Houston, TX 78234 USA. EM jen.e.nyland@gmail.com OI Grigson, Patricia/0000-0002-4252-7332 FU [DA0012473]; [DA009815]; [F31-DA029369] FX This research article was supported by Grants DA0012473, DA009815, and F31-DA029369. NR 79 TC 0 Z9 0 U1 0 U2 3 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0735-7044 EI 1939-0084 J9 BEHAV NEUROSCI JI Behav. Neurosci. PD FEB PY 2016 VL 130 IS 1 BP 103 EP 113 DI 10.1037/bne0000114 PG 11 WC Behavioral Sciences; Neurosciences SC Behavioral Sciences; Neurosciences & Neurology GA DE6LK UT WOS:000370745000011 PM 26653714 ER PT J AU Garg, S Thongcharoen, P Praphasiri, P Chitwarakorn, A Sathirapanya, P Fernandez, S Rungrojcharoenkit, K Chonwattana, W Mock, PA Sukwicha, W Katz, JM Widdowson, MA Curlin, ME Gibbons, RV Holtz, TH Dawood, FS Olsen, SJ AF Garg, Shikha Thongcharoen, Prasert Praphasiri, Prabda Chitwarakorn, Anupong Sathirapanya, Pornchai Fernandez, Stefan Rungrojcharoenkit, Kamonthip Chonwattana, Wannee Mock, Philip A. Sukwicha, Wichuda Katz, Jacqueline M. Widdowson, Marc-Alain Curlin, Marcel E. Gibbons, Robert V. Holtz, Timothy H. Dawood, Fatimah S. Olsen, Sonja J. TI Randomized Controlled Trial to Compare Immunogenicity of Standard-Dose Intramuscular Versus Intradermal Trivalent Inactivated Influenza Vaccine in HIV-Infected Men Who Have Sex With Men in Bangkok, Thailand SO CLINICAL INFECTIOUS DISEASES LA English DT Article DE influenza; vaccine; HIV; immunogenicity; intradermal ID A H1N1 VACCINE; ANTIBODY-RESPONSE; HIV-1-INFECTED PATIENTS; IMMUNE-RESPONSE; CLINICAL-TRIAL; SPLIT VIRION; DOUBLE-BLIND; ADULTS; EFFICACY; INDIVIDUALS AB Background. Individuals infected with human immunodeficiency virus (HIV) are at increased risk for severe influenza, yet immune responses to standard-dose intramuscular (IM) influenza vaccine are suboptimal in this population. Intradermal (ID) delivery of influenza vaccine might improve immune response through enhanced stimulation of dendritic cells. Methods. We conducted a randomized, double-blind, controlled trial to compare the immunogenicity of off-label standard-dose (15 mu g) ID vs standard-dose (15 mu g) IM inactive influenza vaccine in HIV-infected men in Bangkok, Thailand. The primary study outcome was seroconversion (minimum titer of 1:40 and >= 4-fold rise in antibody titer) at 1 month postvaccination based on serum hemagglutination inhibition antibody titers against each vaccine strain. Adverse events (AEs) in the 7 days following vaccination were also assessed. Results. We enrolled 400 HIV-infected participants; 200 were randomly assigned to receive IM and 200 ID vaccine. Vaccine arms were well-balanced with respect to age, CD4 cell count, HIV RNA load, and antiretroviral treatment. Percentage of seroconversion to all (ID 14% vs IM 15%; P=.8) or at least 1 (ID 69% vs IM 68%; P=.7) of the 3 vaccine strains did not differ significantly between ID vs IM vaccine recipients. A higher proportion of participants who received ID vaccine had mild injection-site AEs compared with participants who received IM vaccine (77% vs 27%). Conclusions. There were no significant differences in the immunogenicity of standard-dose ID vs IM influenza vaccine in this HIV-infected population in Thailand. Additional strategies to enhance immune responses to influenza vaccine among HIV-infected persons are needed. C1 [Garg, Shikha; Curlin, Marcel E.; Holtz, Timothy H.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30329 USA. [Garg, Shikha; Katz, Jacqueline M.; Widdowson, Marc-Alain; Dawood, Fatimah S.; Olsen, Sonja J.] Ctr Dis Control & Prevent, Influenza Div, 1600 Clifton Rd NE,Mailstop A-32, Atlanta, GA 30329 USA. [Praphasiri, Prabda; Chonwattana, Wannee; Mock, Philip A.; Sukwicha, Wichuda; Curlin, Marcel E.; Holtz, Timothy H.; Olsen, Sonja J.] Ctr Dis Control & Prevent, Thailand Minist Publ Health US CDC Collaborat, Atlanta, GA USA. [Chitwarakorn, Anupong] Minist Publ Hlth, Dept Dis Control, Nonthaburi, Thailand. [Fernandez, Stefan; Rungrojcharoenkit, Kamonthip; Gibbons, Robert V.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Thongcharoen, Prasert; Sathirapanya, Pornchai] Siriraj Hosp, Bangkok, Thailand. RP Garg, S (reprint author), Ctr Dis Control & Prevent, Influenza Div, 1600 Clifton Rd NE,Mailstop A-32, Atlanta, GA 30329 USA. EM izj7@cdc.gov FU CDC [5U01GH000152] FX This work was supported by the CDC (cooperative agreement 5U01GH000152). NR 43 TC 0 Z9 0 U1 0 U2 2 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD FEB 1 PY 2016 VL 62 IS 3 BP 383 EP 391 DI 10.1093/cid/civ884 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA DD8VS UT WOS:000370205600021 PM 26486702 ER PT J AU Gorzalski, AS Spiesman, AL AF Gorzalski, Alexander S. Spiesman, Anne L. TI Washington Aqueduct: Serving Our Nation's Capital for Over 150 Years SO JOURNAL AMERICAN WATER WORKS ASSOCIATION LA English DT Article C1 [Gorzalski, Alexander S.; Spiesman, Anne L.] US Army Corps Engineers, 5900 MacArthur Blvd NW, Washington, DC 20016 USA. RP Gorzalski, AS (reprint author), US Army Corps Engineers, 5900 MacArthur Blvd NW, Washington, DC 20016 USA. EM Alexander.S.Gorzalski@usace.army.mil NR 11 TC 0 Z9 0 U1 0 U2 0 PU AMER WATER WORKS ASSOC PI DENVER PA 6666 W QUINCY AVE, DENVER, CO 80235 USA SN 2164-4535 J9 J AM WATER WORKS ASS JI J. Am. Water Work Assoc. PD FEB PY 2016 VL 108 IS 2 BP 40 EP 47 DI 10.5942/jawwa.2016.108.0034 PG 8 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA DD8VQ UT WOS:000370205400009 ER PT J AU Jenicek, EM Garfinkle, NW Curvey, LE Case, MP Choi, M Stumpf, AL AF Jenicek, Elisabeth M. Garfinkle, Noah W. Curvey, Laura E. Case, Michael P. Choi, Marianne Stumpf, Annette L. TI Methods of Estimating Water End Use at US Army Installations SO JOURNAL AMERICAN WATER WORKS ASSOCIATION LA English DT Article C1 [Jenicek, Elisabeth M.] US Army Corps Engineers, Engineer Res & Dev Ctr, POB 9005, Champaign, IL 61826 USA. RP Jenicek, EM (reprint author), US Army Corps Engineers, Engineer Res & Dev Ctr, POB 9005, Champaign, IL 61826 USA. EM elisabeth.m.jenicek@usace.army.mil NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER WATER WORKS ASSOC PI DENVER PA 6666 W QUINCY AVE, DENVER, CO 80235 USA SN 2164-4535 J9 J AM WATER WORKS ASS JI J. Am. Water Work Assoc. PD FEB PY 2016 VL 108 IS 2 BP 54 EP 54 DI 10.5942/jawwa.2016.108.0004 PG 1 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA DD8VQ UT WOS:000370205400011 ER PT J AU Reen, BP Dumais, RE Passner, JE AF Reen, Brian P. Dumais, Robert E., Jr. Passner, Jeffrey E. TI Mitigating Excessive Drying from the Use of Observations in Mesoscale Modeling SO JOURNAL OF APPLIED METEOROLOGY AND CLIMATOLOGY LA English DT Article DE Data assimilation; Numerical weather prediction/forecasting; Model initialization; Mesoscale models ID 4-DIMENSIONAL DATA ASSIMILATION; PLANETARY BOUNDARY-LAYER; AIR-QUALITY SIMULATIONS; ENSEMBLE KALMAN FILTER; PART I; METEOROLOGICAL MODEL; RADAR OBSERVATIONS; PREDICTION; IMPACT; SYSTEM AB Observations can be used to enhance mesoscale model forecasts by both improving the initial conditions and adjusting the model state toward the observations during its forward integration. Since observations are not available at the same density as the model grid points, spatial and temporal error correlations must be specified in order to effectively assimilate the observations into the model. Overdrying is found while applying the Weather Research and Forecasting Model to five cases centered over Southern California. This overdrying is caused by incorporation of observations in the initial conditions both at a discrete time and over a preforecast data assimilation period. Nonphysical dryness results from the assumption that model moisture error at the observation location is correlated with model moisture error at other locations in the model without regard to the relative magnitude of the moisture at those two locations. Modifying the model and its preprocessor to remove this assumption greatly reduces the occurrence of excessive model dryness without degrading the overall model performance in predicting moisture. C1 [Reen, Brian P.] US Army, Res Lab, Battlefield Environm Div, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Dumais, Robert E., Jr.; Passner, Jeffrey E.] US Army, Res Lab, Battlefield Environm Div, White Sands Missile Range, NM USA. RP Reen, BP (reprint author), US Army, Res Lab, Battlefield Environm Div, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM brian.p.reen.civ@mail.mil FU National Research Council postdoctoral associateship at the Army Research Laboratory FX AirDat LLC provided TAMDAR observational data that expanded the above-surface data available for data assimilation and verification. This study was made possible in part due to the data made available to the National Oceanic and Atmospheric Administration by various providers for inclusion in MADIS. The RTMA use and reject lists were provided by Steve Levine at the National Centers for Environmental Prediction's Environmental Modeling Center and greatly facilitated making full use of the MADIS observational dataset. The madis2littler tool was provided by Ruifang Li then at the National Center for Atmospheric Research. The first author was supported by a National Research Council postdoctoral associateship at the Army Research Laboratory for part of this research. We thank three anonymous reviewers for their comments, which led to improvements in this manuscript. NR 47 TC 0 Z9 0 U1 1 U2 2 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 1558-8424 EI 1558-8432 J9 J APPL METEOROL CLIM JI J. Appl. Meteorol. Climatol. PD FEB PY 2016 VL 55 IS 2 BP 365 EP 388 DI 10.1175/JAMC-D-14-0301.1 PG 24 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA DE1WZ UT WOS:000370418500001 ER PT J AU Bates, ME Keisler, JM Zussblatt, NP Plourde, KJ Wender, BA Linkov, I AF Bates, Matthew E. Keisler, Jeffrey M. Zussblatt, Niels P. Plourde, Kenton J. Wender, Ben A. Linkov, Igor TI Balancing research and funding using value of information and portfolio tools for nanomaterial risk classification SO NATURE NANOTECHNOLOGY LA English DT Article AB Risk research for nanomaterials is currently prioritized by means of expert workshops and other deliberative processes. However, analytical techniques that quantify and compare alternative research investments are increasingly recommended. Here, we apply value of information and portfolio decision analysis methods commonly applied in financial and operations management to prioritize risk research for multiwalled carbon nanotubes and nanoparticulate silver and titanium dioxide. We modify the widely accepted CB Nanotool hazard evaluation framework, which combines nano- and bulk-material properties into a hazard score, to operate probabilistically with uncertain inputs. Literature is reviewed to develop uncertain estimates for each input parameter, and a Monte Carlo simulation is applied to assess how different research strategies can improve hazard classification. The relative cost of each research experiment is elicited from experts, which enables identification of efficient research portfolios combinations of experiments that lead to the greatest improvement in hazard classification at the lowest cost. Nanoparticle shape, diameter, solubility and surface reactivity were most frequently identified within efficient portfolios in our results. C1 [Bates, Matthew E.; Zussblatt, Niels P.; Plourde, Kenton J.; Wender, Ben A.; Linkov, Igor] US Army Corps Engineers, Environm Lab, Engn Res & Dev Ctr, 696 Virginia Rd, Concord, MA 01742 USA. [Keisler, Jeffrey M.] Univ Massachusetts, Management Sci & Informat Syst Dept, 100 Morrissey Blvd, Boston, MA 02125 USA. [Zussblatt, Niels P.] Univ Calif Santa Barbara, Dept Chem Engn, Mail Code 5080, Santa Barbara, CA 93106 USA. [Wender, Ben A.] Arizona State Univ, Sch Sustainable Engn & Built Environm, POB 875306, Tempe, AZ 85287 USA. RP Bates, ME; Linkov, I (reprint author), US Army Corps Engineers, Environm Lab, Engn Res & Dev Ctr, 696 Virginia Rd, Concord, MA 01742 USA. EM matthew.e.bates@usace.army.mil; igor.linkov@usace.army.mil FU US Army Engineer Research and Development Center; Environmental Protection Agency 'Science to Achieve Results' programme [FP917643]; National Science Foundation [ECCS-1140190, SES-0937591] FX This work was funded by the nanotechnology and emerging material risk research programmes of the US Army Engineer Research and Development Center, by the Environmental Protection Agency 'Science to Achieve Results' programme through grant no. FP917643, and the National Science Foundation through grants nos. ECCS-1140190 and SES-0937591. Publication of this material has been approved by the authority of the Chief of the US Army Corps of Engineers. NR 16 TC 2 Z9 2 U1 4 U2 13 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1748-3387 EI 1748-3395 J9 NAT NANOTECHNOL JI Nat. Nanotechnol. PD FEB PY 2016 VL 11 IS 2 BP 198 EP 203 DI 10.1038/NNANO.2015.249 PG 6 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA DE6UR UT WOS:000370769600019 PM 26551015 ER PT J AU Zhao, ZW Liao, WC Bhagavatula, N Lee, LJ Castro, JM AF Zhao, Ziwei Liao, Wei-Ching Bhagavatula, Narayan Lee, L. James Castro, Jose M. TI Permeability Measurements and Flow Simulation for Polyaniline Carbon Nanofibers Modified Nanopaper on Glass Fiber Preform SO POLYMER COMPOSITES LA English DT Article ID MECHANICAL-PROPERTIES; COMPOSITES; REINFORCEMENT; FABRICATION; ELASTOMERS; COATINGS; MOLDS; MATS; PART AB Carbon nanofibers (CNFs) nanopapers have shown great potential to improve the surface of fiber-reinforced polymeric composites, including providing electromagnetic interference shielding and erosion resistance. During typical resin transfer molding (RTM) process, the CNF nanopaper is incorporated into the fiber preform as a surface layer. To learn how resin flows through the fiber preform and nanopaper layer, permeabilities of the fiber preform and nanopaper need to be measured. As is well known, measuring the permeability of fiber preforms is experimentally challenging. Results usually exhibit large experimental variability. Measuring permeability of nanopapers is even more complicated. To improve the accuracy of results, permeability of CNF-based nanopapers was measured using different experimental setups. In-plane permeability of nanopaper was measured by both unidirectional microslit flow and radial flow approaches. Trans-plane permeability was measured as well, using a trans-plane flow cell and a flow visualization mold. In this article, we discuss the methods used and provide experimental results. We also conducted computational fluid dynamics simulations to study the detailed flow patterns of the nanopaper/RTM process and compared the simulated effect of the nanopaper on retarding the flow (length of the lag) with respect to the glass preform with flow visualization results. (C) 2014 Society of Plastics Engineers C1 [Zhao, Ziwei; Castro, Jose M.] Ohio State Univ, Dept Integrated Syst Engn, 1971 Neil Ave, Columbus, OH 43210 USA. [Liao, Wei-Ching; Lee, L. James] Ohio State Univ, Dept Chem & Biomol Engn, 140 West 19th Ave,125 Koffolt Labs, Columbus, OH 43210 USA. [Bhagavatula, Narayan] US ARMY RDECOM ARDEC, Picatinny Arsenal, NJ 07852 USA. RP Castro, JM (reprint author), Ohio State Univ, Dept Integrated Syst Engn, 1971 Neil Ave, Columbus, OH 43210 USA. EM castro.38@osu.edu NR 29 TC 1 Z9 1 U1 6 U2 18 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0272-8397 EI 1548-0569 J9 POLYM COMPOSITE JI Polym. Compos. PD FEB PY 2016 VL 37 IS 2 BP 435 EP 445 DI 10.1002/pc.23197 PG 11 WC Materials Science, Composites; Polymer Science SC Materials Science; Polymer Science GA DE2XD UT WOS:000370489900014 ER PT J AU Patel, RB Stepanov, V Swaszek, S Surapaneni, A Qiu, HW AF Patel, Rajen B. Stepanov, Victor Swaszek, Sean Surapaneni, Ashok Qiu, Hongwei TI Investigation of CL-20 and RDX Nanocomposites SO PROPELLANTS EXPLOSIVES PYROTECHNICS LA English DT Article DE Nitramine; Explosives; Nanoenergetic; Spray drying; Sensitivity ID RAMAN-SPECTROSCOPY; PARTICLE-SIZE; INITIATION; DEPENDENCE; HMX AB Nanocrystalline explosives offer a number of advantages in comparison to conventional energetics including reduced sensitivity and improved mechanical properties. In this study, formulations consisting of 90% hexanitro-hexaazaisowurtzitane (CL-20) or cyclotrimethylene trinitramine (RDX) and 10% polyvinyl alcohol (PVOH) were prepared with mean crystal sizes ranging from 200nm to 2m. The process to create these materials used a combination of aqueous mechanical crystal size reduction and spray drying. The basic physical characteristics of these formulations were determined using a variety of techniques, including scanning electron microscopy, X-ray diffraction, and Raman spectroscopy. Compressive stress-strain tests on pressed pellets revealed that the mechanical properties of the compositions improved with decreasing crystal size, consistent with Hall-Petch mechanics. In the most extreme case (involving CL-20/PVOH formulations), crystal size reduction from 2m to 300nm improved compressive strength and Young's modulus by 126% and 61%, respectively. These results serve to highlight the relevance of structure-property relationships in explosive compositions, and particularly elucidate the substantial benefits of reducing the high explosive crystal size to nanoscale dimensions. C1 [Patel, Rajen B.; Stepanov, Victor; Swaszek, Sean; Surapaneni, Ashok] US Army, Energet & Warheads Mfg & Technol Div, Picatinny Arsenal, NJ 07806 USA. [Qiu, Hongwei] Leidos Inc, Picatinny Arsenal, NJ 07806 USA. RP Patel, RB; Stepanov, V (reprint author), US Army, Energet & Warheads Mfg & Technol Div, Picatinny Arsenal, NJ 07806 USA. EM rajen.b.patel.civ@mail.mil; victor.stepanov.civ@mail.mil FU US Department of Defense FX This work was performed under the auspices of the US Department of Defense. NR 30 TC 2 Z9 2 U1 8 U2 21 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 0721-3115 EI 1521-4087 J9 PROPELL EXPLOS PYROT JI Propellants Explos. Pyrotech. PD FEB PY 2016 VL 41 IS 1 BP 114 EP 119 DI 10.1002/prep.201500130 PG 6 WC Chemistry, Applied; Engineering, Chemical SC Chemistry; Engineering GA DE0RZ UT WOS:000370333300014 ER PT J AU Stepanov, V Patel, RB Mudryy, R Qiu, HW AF Stepanov, Victor Patel, Rajen B. Mudryy, Ruslan Qiu, Hongwei TI Investigation of Nitramine-Based Amorphous Energetics SO PROPELLANTS EXPLOSIVES PYROTECHNICS LA English DT Article DE Amorphous; Glassy; Energetics; Nitramine; CL-20; Spray drying ID CRYSTALLIZATION; INDOMETHACIN; DISPERSIONS; SENSITIVITY AB To date, the use of high explosives (HEs) has been largely limited to their crystalline forms. The glassy forms of these materials have not received much attention. While the highest density and stability of HEs is only attainable in the crystalline state, the unique properties exhibited by glasses may offer significant practical advantages. In this work, the production and properties of glassy molecular dispersions based on CL-20 with HMX and polyvinyl acetate additives were investigated. The glassy form was achieved by rapid precipitation of the composite ingredients using spray drying. The role of the additives on glass formation was examined. Characterization revealed multiple novel properties in comparison to the traditional crystalline HE-based compositions. Differential scanning calorimetry (DSC) analysis showed that in the glassy state the materials have a higher configurational enthalpy, by as much as 42Jg(-1). Thermomechanical analysis (TMA) results indicate that the glassy materials undergo a glass transition at around 50 degrees C, during which a transformation from a rigid to a liquid-like state occurs. The glasses showed a tendency to crystallize, as was observed with TMA and DSC analysis. It was observed that the stability of the amorphous phase with respect to crystallization improved with increasing pellet density. These findings serve to highlight the unique opportunity presented by glassy energetics to achieve improvements beyond those attainable with traditional crystalline materials. C1 [Stepanov, Victor; Patel, Rajen B.; Mudryy, Ruslan] US Army, RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA. [Qiu, Hongwei] Leidos Inc, Picatinny Arsenal, NJ 07806 USA. RP Stepanov, V (reprint author), US Army, RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA. EM victor.stepanov.civ@mail.mil FU U.S. Department of Defense FX This work was performed under the auspices of the U.S. Department of Defense. NR 19 TC 0 Z9 0 U1 4 U2 8 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 0721-3115 EI 1521-4087 J9 PROPELL EXPLOS PYROT JI Propellants Explos. Pyrotech. PD FEB PY 2016 VL 41 IS 1 BP 142 EP 147 DI 10.1002/prep.201500118 PG 6 WC Chemistry, Applied; Engineering, Chemical SC Chemistry; Engineering GA DE0RZ UT WOS:000370333300018 ER PT J AU Abraham, A Piekiel, NW Morris, CJ Dreizin, EL AF Abraham, Ani Piekiel, Nicholas W. Morris, Christopher J. Dreizin, Edward L. TI Combustion of Energetic Porous Silicon Composites Containing Different Oxidizers SO PROPELLANTS EXPLOSIVES PYROTECHNICS LA English DT Article DE Porous silicon; On-chip energetic materials; Combustion; Sulfur; Nitrate ID FILMS AB We present a quantitative investigation of combustion of on-chip porous silicon (PS) energetic materials using oxidizers with improved moisture stability and/or minimized environmental impact compared to sodium perchlorate (NaClO4). Material properties of the PS films were characterized using gas adsorption porosimetry and profilometry to determine specific surface area, porosity, and etch depth. PS energetic composites were formed using melt-penetrated or solution-deposited oxidizers into the pores. Combustion was characterized by high speed imaging and bomb calorimetry. The flame speeds quantified for PS/sulfur and PS/nitrate systems varied in the ranges of 2.9-3.7ms(-1)and 3.1-21ms(-1), respectively. The experimental combustion enthalpies are reported for different oxidizer systems in both inert and oxidizing environments. For the PS/sulfur and the PS/nitrate systems, the experimental heats of combustion were comparable to those calculated for the thermodynamic equilibrium and taking into account an increased reactivity of PS due to the hydrogen terminated silicon surface. C1 [Abraham, Ani; Piekiel, Nicholas W.; Morris, Christopher J.] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. [Abraham, Ani; Dreizin, Edward L.] New Jersey Inst Technol, Newark, NJ 07102 USA. RP Morris, CJ (reprint author), US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. EM christopher.j.morris58.civ@mail.mil RI Dreizin, Edward/O-6416-2014 NR 37 TC 2 Z9 2 U1 1 U2 10 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 0721-3115 EI 1521-4087 J9 PROPELL EXPLOS PYROT JI Propellants Explos. Pyrotech. PD FEB PY 2016 VL 41 IS 1 BP 179 EP 188 DI 10.1002/prep.201500108 PG 10 WC Chemistry, Applied; Engineering, Chemical SC Chemistry; Engineering GA DE0RZ UT WOS:000370333300024 ER PT J AU Singh, J Haines, C AF Singh, Jogender Haines, Chris TI FIELD ASSISTED SINTERING TECHNOLOGY UPDATE-PART I SO ADVANCED MATERIALS & PROCESSES LA English DT Editorial Material C1 [Singh, Jogender] Penn State Univ, Dept Mat Sci & Engn, FAST Ctr Excellence, University Pk, PA 16801 USA. [Haines, Chris] US Army, RDECOM, ARDEC, Picatinny Arsenal, NJ USA. RP Singh, J (reprint author), Penn State Univ, Dept Mat Sci & Engn, FAST Ctr Excellence, University Pk, PA 16801 USA. EM jxs46@psu.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASM INT PI MATERIALS PARK PA SUBSCRIPTIONS SPECIALIST CUSTOMER SERVICE, MATERIALS PARK, OH 44073-0002 USA SN 0882-7958 EI 2161-9425 J9 ADV MATER PROCESS JI Adv. Mater. Process. PD FEB PY 2016 VL 174 IS 2 BP 20 EP 24 PG 5 WC Materials Science, Multidisciplinary SC Materials Science GA DD2VP UT WOS:000369780600010 ER PT J AU Akkina, R Allam, A Balazs, AB Blankson, JN Burnett, JC Casares, S Garcia, JV Hasenkrug, KJ Kashanchi, F Kitchen, SG Klein, F Kumar, P Luster, AD Poluektova, LY Rao, M Sanders-Beer, BE Shultz, LD Zack, JA AF Akkina, Ramesh Allam, Atef Balazs, Alejandro B. Blankson, Joel N. Burnett, John C. Casares, Sofia Garcia, J. Victor Hasenkrug, Kim J. Kashanchi, Fatah Kitchen, Scott G. Klein, Florian Kumar, Priti Luster, Andrew D. Poluektova, Larisa Y. Rao, Mangala Sanders-Beer, Brigitte E. Shultz, Leonard D. Zack, Jerome A. TI Improvements and Limitations of Humanized Mouse Models for HIV Research: NIH/NIAID "Meet the Experts" 2015 Workshop Summary SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID IMMUNODEFICIENCY-VIRUS ENCEPHALITIS; BROADLY NEUTRALIZING ANTIBODIES; HEMATOPOIETIC STEM-CELLS; SCID-HU MOUSE; T-CELLS; BLT MICE; IN-VIVO; VAGINAL TRANSMISSION; INFECTIOUS-DISEASES; IMMUNE-RESPONSES AB The number of humanized mouse models for the human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) and other infectious diseases has expanded rapidly over the past 8 years. Highly immunodeficient mouse strains, such as NOD/SCID/gamma chain(null) (NSG, NOG), support better human hematopoietic cell engraftment. Another improvement is the derivation of highly immunodeficient mice, transgenic with human leukocyte antigens (HLAs) and cytokines that supported development of HLA-restricted human T cells and heightened human myeloid cell engraftment. Humanized mice are also used to study the HIV reservoir using new imaging techniques. Despite these advances, there are still limitations in HIV immune responses and deficits in lymphoid structures in these models in addition to xenogeneic graft-versus-host responses. To understand and disseminate the improvements and limitations of humanized mouse models to the scientific community, the NIH sponsored and convened a meeting on April 15, 2015 to discuss the state of knowledge concerning these questions and best practices for selecting a humanized mouse model for a particular scientific investigation. This report summarizes the findings of the NIH meeting. C1 [Akkina, Ramesh] Colorado State Univ, Dept Microbiol Immunol & Pathol, Ft Collins, CO 80523 USA. [Allam, Atef] Henry M Jackson Fdn Adv Mil Med, Silver Spring, MD USA. [Allam, Atef; Rao, Mangala] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Balazs, Alejandro B.] Ragon Inst MGH MIT & Harvard, Cambridge, MA USA. [Blankson, Joel N.] Johns Hopkins Univ, Sch Med, Dept Med, Ctr AIDS Res, Baltimore, MD 21205 USA. [Burnett, John C.] Beckman Res Inst City Hope, Dept Mol & Cellular Biol, Duarte, CA USA. [Casares, Sofia] Naval Med Res Ctr, US Mil Malaria Vaccine Program, Silver Spring, MD USA. [Garcia, J. Victor] Univ N Carolina, Dept Med, Div Infect Dis, UNC Ctr AIDS Res, Chapel Hill, NC USA. [Hasenkrug, Kim J.] NIAID, Lab Persistent Viral Dis, Rocky Mt Labs, NIH, Hamilton, MT USA. [Kashanchi, Fatah] George Mason Univ, Sch Syst Biol, Natl Ctr Biodef & Infect Dis, Manassas, VA USA. [Kitchen, Scott G.; Zack, Jerome A.] Univ Calif Los Angeles, AIDS Inst, Dept Med & Microbiol, Los Angeles, CA USA. [Kitchen, Scott G.; Zack, Jerome A.] Univ Calif Los Angeles, AIDS Inst, Dept Immunol & Mol Genet, Los Angeles, CA USA. [Klein, Florian] Univ Hosp Cologne, Dept Internal Med 1, Cologne, Germany. [Klein, Florian] Univ Cologne, CMMC, D-50931 Cologne, Germany. [Kumar, Priti] Yale Univ, Sch Med, Infect Dis Internal Med, New Haven, CT USA. [Luster, Andrew D.] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Div Rheumatol Allergy & Immunol,Ctr Immunol & Inf, Boston, MA 02115 USA. [Poluektova, Larisa Y.] Univ Nebraska Med Ctr, Dept Pharmacol & Expt Neurosci, Omaha, NE USA. [Sanders-Beer, Brigitte E.] NIAID, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA. [Shultz, Leonard D.] Jackson Lab, 600 Main St, Bar Harbor, ME 04609 USA. RP Sanders-Beer, BE (reprint author), NIAID, BSP, DAIDS, NIH,DHHS, 5601 Fishers Lane,Room 9G58, Rockville, MD 20852 USA. EM sandersbe@niaid.nih.gov OI Burnett, John/0000-0002-8817-6064 FU National Institute of Allergies and Infectious Diseases, National Institutes of Health, Department of Health and Human Services [HHSN272201100001G] FX The workshop was funded in whole with Federal funds from the National Institute of Allergies and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under contract no. HHSN272201100001G. NR 76 TC 3 Z9 3 U1 1 U2 3 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD FEB 1 PY 2016 VL 32 IS 2 BP 109 EP 119 DI 10.1089/aid.2015.0258 PG 11 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA DD2NY UT WOS:000369760500001 PM 26670361 ER PT J AU Bushman, TT Grier, TL Canham-Chervak, M Anderson, MK North, WJ Jones, BH AF Bushman, Timothy T. Grier, Tyson L. Canham-Chervak, Michelle Anderson, Morgan K. North, William J. Jones, Bruce H. TI The Functional Movement Screen and Injury Risk: Association and Predictive Value in Active Men SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article DE military training; epidemiology; injury prevention; Functional Movement Screen; predictive value ID INTERRATER RELIABILITY; INTRARATER RELIABILITY; INFANTRY; SOLDIERS; FITNESS AB Background: The Functional Movement Screen (FMS) is a series of 7 tests used to assess the injury risk in active populations. Purpose: To determine the association of the FMS with the injury risk, assess predictive values, and identify optimal cut points using 3 injury types. Study Design: Cohort study; Level of evidence, 2. Methods: Physically active male soldiers aged 18 to 57 years (N = 2476) completed the FMS. Demographic and fitness data were collected by survey. Medical record data for overuse injuries, traumatic injuries, and any injury 6 months after the FMS assessment were obtained. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated along with the receiver operating characteristic (ROC) to determine the area under the curve (AUC) and identify optimal cut points for the risk assessment. Risks, risk ratios (RRs), odds ratios (ORs), and 95% CIs were calculated to assess injury risks. Results: Soldiers who scored 14 were at a greater risk for injuries compared with those who scored >14 using the composite score for overuse injuries (RR, 1.84; 95% CI, 1.63-2.09), traumatic injuries (RR, 1.26; 95% CI, 1.03-1.54), and any injury (RR, 1.60; 95% CI, 1.45-1.77). When controlling for other known injury risk factors, multivariate logistic regression analysis identified poor FMS performance (OR [score 14/19-21], 2.00; 95% CI, 1.42-2.81) as an independent risk factor for injuries. A cut point of 14 registered low measures of predictive value for all 3 injury types (sensitivity, 28%-37%; PPV, 19%-52%; AUC, 54%-61%). Shifting the injury risk cut point of 14 to the optimal cut points indicated by the ROC did not appreciably improve sensitivity or the PPV. Conclusion: Although poor FMS performance was associated with a higher risk of injuries, it displayed low sensitivity, PPV, and AUC. On the basis of these findings, the use of the FMS to screen for the injury risk is not recommended in this population because of the low predictive value and misclassification of the injury risk. C1 [Bushman, Timothy T.; Grier, Tyson L.; Canham-Chervak, Michelle; Anderson, Morgan K.; Jones, Bruce H.] US Army, Inst Publ Hlth, Directorate Epidemiol & Dis Surveillance, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. [North, William J.] Henry Jackson Fdn, Ft Carson, CO USA. RP Bushman, TT (reprint author), US Army, Inst Publ Hlth, Directorate Epidemiol & Dis Surveillance, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM Timothy.t.bushman.ctr@mail.mil NR 43 TC 1 Z9 1 U1 6 U2 21 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0363-5465 EI 1552-3365 J9 AM J SPORT MED JI Am. J. Sports Med. PD FEB PY 2016 VL 44 IS 2 BP 297 EP 304 DI 10.1177/0363546515614815 PG 8 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA DD5RZ UT WOS:000369983300004 PM 26657573 ER PT J AU Boddu, VM Brenner, MW AF Boddu, Veera M. Brenner, Matthew W. TI Energy dissipation in intercalated carbon nanotube forests with metal layers SO APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING LA English DT Article ID MECHANICAL-PROPERTIES; COMPOSITES; GROWTH; ARRAYS; WIRES; TIPS AB Vertically aligned carbon nanotube (CNT) forests were synthesized to study their quasi-static mechanical properties in a layered configuration with metallization. The top and bottom surfaces of CNT forests were metalized with Ag, Fe, and In using paste, sputtering, and thermal evaporation, respectively. Stacks of one, two, and three layers of these forests were assembled and compressed to measure their mechanical properties. The samples were strain limited to 0.7, and the results indicate that energy dissipation is approximately linear with respect to the number of layers and relatively independent of metal type. The energy per unit volume was approximately the same for all samples. Successive stacking of CNT forests reduces local buckling events, which is enhanced with a thick Ag deposition on the CNT forest surface. Young's modulus was also observed to increase as the number of layers was increased. These results are useful in the design of composite materials for high energy absorption and high stiffness applications. C1 [Boddu, Veera M.; Brenner, Matthew W.] US Army Engn Res & Dev Ctr, Construct Engn Res Lab ERDC CERL, Environm Proc Branch, Champaign, IL 61826 USA. [Boddu, Veera M.] ARS, Plant Polymer Res Unit, Natl Ctr Agr Utilizat Res, USDA, 1815 N Univ St, Peoria, IL 61604 USA. RP Boddu, VM (reprint author), US Army Engn Res & Dev Ctr, Construct Engn Res Lab ERDC CERL, Environm Proc Branch, Champaign, IL 61826 USA.; Boddu, VM (reprint author), ARS, Plant Polymer Res Unit, Natl Ctr Agr Utilizat Res, USDA, 1815 N Univ St, Peoria, IL 61604 USA. EM Veera.Boddu@ars.usda.gov NR 34 TC 0 Z9 0 U1 3 U2 7 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0947-8396 EI 1432-0630 J9 APPL PHYS A-MATER JI Appl. Phys. A-Mater. Sci. Process. PD FEB PY 2016 VL 122 IS 2 AR 88 DI 10.1007/s00339-015-9571-8 PG 11 WC Materials Science, Multidisciplinary; Physics, Applied SC Materials Science; Physics GA DD5OB UT WOS:000369972400043 ER PT J AU Ruff, AL Beach, S Lehman, J Rothwell, C Dillman, JF AF Ruff, Albert L. Beach, Sarah Lehman, John Rothwell, Cristin Dillman, James F. TI Identification and validation of vesicant therapeutic targets using a high-throughput siRNA screening approach SO ARCHIVES OF TOXICOLOGY LA English DT Article DE Sulfur mustard; Cutaneous injury; siRNA; High-throughput screening; Inflammation; In vitro models ID SULFUR MUSTARD; GENE-EXPRESSION; NATRIURETIC-PEPTIDE; MICROARRAY ANALYSIS; HUMAN KERATINOCYTE; ALKYLATING-AGENTS; LESIONS; ROLES; CORIN; P38 AB Sulfur mustard [SM, bis-(2-chloroethyl) sulfide] is a highly reactive bifunctional alkylating agent that has been used as a vesicating agent in warfare scenarios to induce severe lung, skin, and eye injury. SM cutaneous lesions are characterized by both vesication and severe inflammation, but the molecular mechanisms that lead to these signs and symptoms are not well understood. There is a pressing need for effective therapeutics to treat this injury. An understanding of the molecular mechanisms of injury and identification of potential therapeutic targets is necessary for rational therapeutic development. We have applied a high-throughput small interfering RNA (siRNA) screening approach to the problem of SM cutaneous injury in an effort to meet these needs. Our siRNA screening efforts have initially focused on SM-induced inflammation in cutaneous injury since chronic inflammation after exposure appears to play a role in progressive clinical pathology, and intervention may improve clinical outcome. Also, targets that mitigate cellular injury should reduce the inflammatory response. Historical microarray data on this injury were mined for targets and pathways implicated in inflammation, and a siRNA library of 2,017 targets was assembled for screening. Primary screening and library deconvolution were performed using human HaCaT keratinocytes and focused on cell death and inflammatory markers as end points. Using this in vitro approach, we have identified and validated novel targets for the potential treatment of SM-induced cutaneous injury. C1 [Ruff, Albert L.; Beach, Sarah; Lehman, John; Rothwell, Cristin; Dillman, James F.] US Army, Med Res Inst Chem Def, Div Res, Cell & Mol Biol Branch, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. RP Ruff, AL (reprint author), US Army, Med Res Inst Chem Def, Div Res, Cell & Mol Biol Branch, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM albert.l.ruff2.civ@mail.mil FU Defense Threat Reduction Agency-Joint Science and Technology Office, Medical ST Division [CBM.CUTOC.04.10.RC.001] FX This research was supported by the Defense Threat Reduction Agency-Joint Science and Technology Office, Medical S&T Division, Project ID Number CBM.CUTOC.04.10.RC.001. NR 24 TC 0 Z9 0 U1 2 U2 5 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 0340-5761 EI 1432-0738 J9 ARCH TOXICOL JI Arch. Toxicol. PD FEB PY 2016 VL 90 IS 2 BP 375 EP 383 DI 10.1007/s00204-014-1427-z PG 9 WC Toxicology SC Toxicology GA DD8SD UT WOS:000370196300012 PM 25537185 ER PT J AU Hostler, DC Marx, ES Moores, LK Petteys, SK Hostler, JM Mitchell, JD Holley, PR Collen, JF Foster, BE Holley, AB AF Hostler, David C. Marx, Elizabeth S. Moores, Lisa K. Petteys, Sarah K. Hostler, Jordanna Mae Mitchell, Joshua D. Holley, Paul R. Collen, Jacob F. Foster, Brian E. Holley, Aaron B. TI Validation of the International Medical Prevention Registry on Venous Thromboembolism Bleeding Risk Score SO CHEST LA English DT Article DE antibiotic therapy; deep venous thrombosis; pulmonary embolism ID DEEP-VEIN THROMBOSIS; ANTITHROMBOTIC THERAPY; HOSPITALIZED-PATIENTS; NONSURGICAL PATIENTS; PRACTICE GUIDELINES; PULMONARY-EMBOLISM; AMERICAN-COLLEGE; PROPHYLAXIS; EPIDEMIOLOGY; PHYSICIANS AB BACKGROUND: Recent guidelines recommend assessing medical inpatients for bleeding risk prior to providing chemical prophylaxis for VTE. The International Medical Prevention Registry on Venous Thromboembolism (IMPROVE) bleeding risk score (BRS) was derived from a well-defined population of medical inpatients but it has not been validated externally. We sought to externally validate the IMPROVE BRS. METHODS: We prospectively collected characteristics on admission and VTE prophylaxis data each hospital day for all patients admitted for a medical illness to the Walter Reed Army Medical Center over an 18-month period. We calculated the IMPROVE BRS for each patient using admission data and reviewed medical records to identify bleeding events. RESULTS: From September 2009 through March 2011, 1,668 inpatients met the IMPROVE inclusion criteria. Bleeding events occurred during 45 separate admissions (2.7%); 31 events (1.9%) were major and 14 (0.8%) were nonmajor but clinically relevant. Two hundred fiftysix patients (20.7%) had an IMPROVE BRS >= 7.0. Kaplan-Meier curves showed a higher cumulative incidence of major (P = .02) and clinically important (major plus clinically relevant nonmajor) (P = .06) bleeding within 14 days in patients with an IMPROVE BRS >= 7.0. An IMPROVE BRS >= 7.0 was associated with major bleeding in Cox-regression analysis adjusted for administration of chemical prophylaxis (OR, 2.6; 95% CI, 1.1-5.9; P = .03); there was a trend toward a significant association with clinically important bleeding (OR, 1.9; 95% CI, 0.9-3.7; P = .07). CONCLUSIONS: The IMPROVE BRS calculated at admission predicts major bleeding in medical inpatients. This model may help assess the relative risks of bleeding and VTE before chemoprophylaxis is administered. C1 [Hostler, David C.; Petteys, Sarah K.] Walter Reed Natl Mil Med Ctr, Dept Pulm & Crit Care Med, Bethesda, MD 20889 USA. [Marx, Elizabeth S.] Walter Reed Natl Mil Med Ctr, Dept Pediat, Bethesda, MD 20889 USA. [Hostler, Jordanna Mae; Holley, Aaron B.] Walter Reed Natl Mil Med Ctr, Dept Pulm Crit Care & Sleep Med, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. [Mitchell, Joshua D.; Foster, Brian E.] Walter Reed Natl Mil Med Ctr, Dept Internal Med, Bethesda, MD 20889 USA. [Moores, Lisa K.] Uniformed Serv Univ Hlth Sci, Dept Med, Room A3060, Bethesda, MD 20814 USA. [Holley, Paul R.] US Army, Med Res Inst Infect Dis, Dept Informat, Frederick, MD USA. [Collen, Jacob F.] San Antonio Mil Med Ctr, Dept Pulm & Crit Care Med, San Antonio, TX USA. RP Holley, AB (reprint author), Walter Reed Natl Mil Med Ctr, Dept Pulm Crit Care & Sleep Med, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. EM aholley9@gmail.com NR 28 TC 2 Z9 2 U1 0 U2 3 PU AMER COLL CHEST PHYSICIANS PI GLENVIEW PA 2595 PATRIOT BLVD, GLENVIEW, IL 60026 USA SN 0012-3692 J9 CHEST JI Chest PD FEB PY 2016 VL 149 IS 2 BP 372 EP 379 DI 10.1378/chest.14-2842 PG 8 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA DD1DC UT WOS:000369660400020 PM 26867833 ER PT J AU Lettieri, CJ Williams, SG Collen, JF AF Lettieri, Christopher J. Williams, Scott G. Collen, Jacob F. TI OSA Syndrome and Posttraumatic Stress Disorder Clinical Outcomes and Impact of Positive Airway Pressure Therapy SO CHEST LA English DT Article DE continuous positive airway pressure; CPAP adherence; obstructive sleep apnea; posttraumatic stress disorder; quality of life ID OBSTRUCTIVE SLEEP-APNEA; QUALITY-OF-LIFE; TRAUMATIC BRAIN-INJURY; CPAP USE; DAYTIME SLEEPINESS; MILITARY PERSONNEL; FUNCTIONAL STATUS; ADHERENCE; INSOMNIA; NIGHTMARES AB BACKGROUND: We sought to determine the impact of OSA syndrome (OSAS) on symptoms and quality of life (QoL) among patients with posttraumatic stress disorder (PTSD). In addition, we assessed adherence and response to positive airway pressure (PAP) therapy in this population. METHODS: This was a case-controlled observational cohort study at the Sleep Disorders Center of an academic military medical center. Two hundred consecutive patients with PTSD underwent sleep evaluations. Patients with PTSD with and without OSAS were compared with 50 consecutive age-matched patients with OSAS without PTSD and 50 age-matched normal control subjects. Polysomnographic data, sleep-related symptoms and QoL measures, and objective PAP usage were obtained. RESULTS: Among patients with PTSD, more than one-half (56.6%) received a diagnosis of OSAS. Patients with PTSD and OSAS had lower QoL and more somnolence compared with the other groups. Patients with PTSD demonstrated significantly lower adherence and response to PAP therapy. Resolution of sleepiness occurred in 82% of patients with OSAS alone, compared with 62.5% of PAP-adherent and 21.4% of nonadherent patients with PTSD and OSAS (P < .001). Similarly, posttreatment Functional Outcomes of Sleep Questionnaire >= 17.9 was achieved in 72% of patients with OSAS, compared with only 56.3% of patients with PTSD and OSA who were PAP adherent and 26.2% who were nonadherent (P < .03). CONCLUSIONS: In patients with PTSD, comorbid OSAS is associated with worsened symptoms, QoL, and adherence and response to PAP. Given the negative impact on outcomes, the possibility of OSAS should be considered carefully in patients with PTSD. Close follow-up is needed to optimize PAP adherence and efficacy in this at-risk population. C1 [Lettieri, Christopher J.; Williams, Scott G.; Collen, Jacob F.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD USA. [Lettieri, Christopher J.] Walter Reed Natl Mil Med Ctr, Dept Pulm Crit Care & Sleep Med, Bethesda, MD USA. [Williams, Scott G.] Womack Army Med Ctr, Dept Pulm Crit Care & Sleep Med, Ft Bragg, NC USA. [Collen, Jacob F.] Brooke Army Med Ctr, Dept Pulm Crit Care & Sleep Med, Ft Sam Houston, TX 78234 USA. RP Collen, JF (reprint author), Brooke Army Med Ctr, Pulm Crit Care & Sleep Med, San Antonio Mil Med Ctr, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM jacob.f.collen.mil@mail.mil NR 57 TC 5 Z9 5 U1 1 U2 2 PU AMER COLL CHEST PHYSICIANS PI GLENVIEW PA 2595 PATRIOT BLVD, GLENVIEW, IL 60026 USA SN 0012-3692 J9 CHEST JI Chest PD FEB PY 2016 VL 149 IS 2 BP 483 EP 490 DI 10.1378/chest.15-0693 PG 8 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA DD1DC UT WOS:000369660400031 PM 26291560 ER PT J AU Briant, LJB Charkoudian, N Hart, EC AF Briant, L. J. B. Charkoudian, N. Hart, E. C. TI Sympathetic regulation of blood pressure in normotension and hypertension: when sex matters SO EXPERIMENTAL PHYSIOLOGY LA English DT Article ID RENIN-ANGIOTENSIN SYSTEM; POINT CHRONIC ACTIVATION; ALL-CAUSE MORTALITY; NERVE ACTIVITY; DOMINANT CONTRIBUTOR; ARTERIAL STIFFNESS; POSTMENOPAUSAL WOMEN; AUTONOMIC SUPPORT; COUNTERPOINT ACTIVATION; CARDIOVASCULAR EVENTS AB New Findings What is the topic of this review? Hypertension is a major problem in Western society. Risk of hypertension increases with age, especially in women, who have lower risk compared with men until menopause. This review outlines the sex differences in the sympathetic control of blood pressure and how these mechanisms change with age. What advances does it highlight? It has recently been recognized that men and women regulate blood pressure by different physiological mechanisms. This is important for both the understanding and the clinical management of individual patients with hypertension. This review summarizes recent advances in understanding how the regulation of blood pressure in hypertension by the sympathetic nervous system differs between men and women. The sympathetic nervous system has a central role in the regulation of arterial blood pressure (BP) and in the development of hypertension in humans. Recent evidence points to differences between the sexes in the integrative mechanisms by which BP is controlled, suggesting that the development of hypertension may follow distinct pathways in women compared with men. An important aspect of sympathetic control of BP is its substantial interindividual variability. In healthy young men, the variability in sympathetic nerve activity (SNA) is balanced by variability in cardiac output and vascular adrenergic responses, such that BP remains similar, and normal, across a severalfold range of resting SNA values. In young women, variability in resting SNA is similar to that seen in men, but the balancing' mechanisms are strikingly different; women exhibit greater -adrenergic vasodilatation compared with men, which minimizes the pressor effects of a given level of SNA. Ageing is associated with increased SNA and a loss of the balancing factors seen in younger people, leading to an increased risk of hypertension in older people. Loss of oestrogen with menopause in women appears to be linked mechanistically with the decrease in -adrenergic vasodilatation and the increased risk of hypertension in older women. Other important factors contributing to hypertension via sympathetic mechanisms are obesity and arterial stiffening, both of which increase with ageing. We conclude with a discussion of important areas in which more work is needed to understand and manage appropriately the sex-specific mechanisms in the development and maintenance of hypertension. C1 [Briant, L. J. B.; Hart, E. C.] Univ Bristol, Clin Res & Imaging Ctr, Cardion Grp, Bristol, Avon, England. [Charkoudian, N.] US Army, Environm Med Res Inst, Natick, MA 01760 USA. RP Hart, EC (reprint author), Univ Bristol, Clin Res & Imaging Ctr, Cardion Grp, Bristol, Avon, England.; Hart, EC (reprint author), CardioN Res Grp, Med Sci Bldg, Bristol BS8 1TD, Avon, England. EM emma.hart@bristol.ac.uk FU British Heart Foundation [FS/11/1/28400] NR 95 TC 3 Z9 3 U1 3 U2 11 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0958-0670 EI 1469-445X J9 EXP PHYSIOL JI Exp. Physiol. PD FEB 1 PY 2016 VL 101 IS 2 BP 219 EP 229 DI 10.1113/EP085368 PG 11 WC Physiology SC Physiology GA DD3ZU UT WOS:000369862900003 PM 26682826 ER PT J AU Ryan, LTCPM Rodriguez, MAJRM AF Ryan, L. T. C. Paul M. Rodriguez, M. A. J. Ryan M. TI Outcomes and Return to Activity After Operative Repair of Chronic Latent Syndesmotic Instability SO FOOT & ANKLE INTERNATIONAL LA English DT Article DE arthritis; biomechanics; sports; trauma; outcome studies ID DISTAL TIBIOFIBULAR SYNDESMOSIS; RADIOGRAPHIC EVALUATION; ANKLE SYNDESMOSIS; DIAGNOSIS; ARTHROSCOPY; FIXATION; FRACTURE; SPRAINS AB Background: This study is a retrospective review of prospectively gathered data determining the postoperative outcomes of patients who underwent operative treatment to address chronic syndesmotic instability. Methods: The cohort is composed of 19 individuals who elected to undergo operative treatment of chronic syndesmotic instability. The operative repair consisted of arthroscopic debridement in all cases with reduction and suture button fixation of those patients who had greater than 4 mm of syndesmotic diastasis on arthroscopic evaluation. All patients had a minimum of 24 months follow-up. This study retrospectively examined the prospectively gathered preoperative and postoperative outcome scores to include a Visual Analog Scale (VAS) pain score and an American Orthopaedic Foot & Ankle Society (AOFAS) ankle-hindfoot score. In addition, patients were questioned on their ability to return to their preinjury level of activity and their ability to continue running sports. Fourteen patients returned their postoperative surveys. Results: Mean AOFAS scores improved significantly from 48 to 82.7 (P = .014). Mean VAS scores improved from 6.1 to 1.0 (P = .002). Overall, 86% (12/14) of patients were able to return to running and 79% (11/14) of patients were able to return to their preinjury level of sport. Preoperative and postoperative weight-bearing ankle radiographs were reviewed to evaluate the tibiofibular clear space and overlap. The clear space measured on anteroposterior (AP) radiographs decreased from 5.4 mm to 4.6 mm (P = .005), the clear space evaluated on the mortise radiograph decreased from 4.5 mm to 3.6 mm (P = .006), and the overlap measured on the AP radiograph increased from 5.7 mm to 6.9 mm (P = .019). All radiographs were measured by a board-certified musculoskeletal radiologist. Conclusion: This study presents a treatment method that can be instituted at the time of diagnosis for syndesmotic injuries with greater than 4 mm of diastasis that were treated with debridement and stabilization. The results of this treatment technique are promising, with significant improvements in subjective outcome scores and a high rate of return to running sports. Level of Evidence: Level IV, retrospective case series. C1 [Ryan, L. T. C. Paul M.] Orthopaed Clin, Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA. [Rodriguez, M. A. J. Ryan M.] Orthopaed Clin, Madigan Army Med Ctr, Tacoma, WA USA. RP Ryan, LTCPM (reprint author), Orthopaed Clin, Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM paul.m.ryan.mil@mail.mil NR 24 TC 2 Z9 2 U1 1 U2 3 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1071-1007 EI 1944-7876 J9 FOOT ANKLE INT JI Foot Ankle Int. PD FEB PY 2016 VL 37 IS 2 BP 192 EP 197 DI 10.1177/1071100715606488 PG 6 WC Orthopedics SC Orthopedics GA DD5KD UT WOS:000369961600010 ER PT J AU Chou, R Gordon, DB de Leon-Casasola, OA Rosenberg, JM Bickler, S Brennan, T Carter, T Cassidy, CL Chittenden, EH Degenhardt, E Griffith, S Manworren, R McCarberg, B Montgomery, R Murphy, J Perkal, MF Suresh, S Sluka, K Strassels, S Thirlby, R Viscusi, E Walco, GA Warner, L Weisman, SJ Wu, CL AF Chou, Roger Gordon, Debra B. de Leon-Casasola, Oscar A. Rosenberg, Jack M. Bickler, Stephen Brennan, Tim Carter, Todd Cassidy, Carla L. Chittenden, Eva Hall Degenhardt, Ernest Griffith, Scott Manworren, Renee McCarberg, Bill Montgomery, Robert Murphy, Jamie Perkal, Melissa F. Suresh, Santhanam Sluka, Kathleen Strassels, Scott Thirlby, Richard Viscusi, Eugene Walco, Gary A. Warner, Lisa Weisman, Steven J. Wu, Christopher L. TI Management of Postoperative Pain: A Clinical Practice Guideline From the American Pain Society, the American Society of Regional Anesthesia and Pain Medicine, and the American Society of Anesthesiologists' Committee on Regional Anesthesia, Executive Committee, and Administrative Council SO JOURNAL OF PAIN LA English DT Article DE Postoperative pain management; clinical practice guidelines; analgesia; education; multi-modal therapy; patient assessment; regional analgesia; neuraxial analgesia ID TOTAL KNEE ARTHROPLASTY; CRUCIATE LIGAMENT RECONSTRUCTION; PATIENT-CONTROLLED ANALGESIA; RANDOMIZED CONTROLLED-TRIAL; ELECTRICAL NERVE-STIMULATION; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; INTRAARTICULAR BUPIVACAINE INFUSION; PERSISTENT POSTSURGICAL PAIN; LIDOCAINE-PRILOCAINE CREAM; PLACEBO-CONTROLLED TRIAL AB Most patients who undergo surgical procedures experience acute postoperative pain, but evidence suggests that less than half report adequate postoperative pain relief. Many preoperative, intra-operative, and postoperative interventions and management strategies are available for reducing and managing postoperative pain. The American Pain Society, with input from the American Society of Anesthesiologists, commissioned an interdisciplinary expert panel to develop a clinical practice guideline to promote evidence-based, effective, and safer postoperative pain management in children and adults. The guideline was subsequently approved by the American Society for Regional Anesthesia. As part of the guideline development process, a systematic review was commissioned on various aspects related to various interventions and management strategies for postoperative pain. After a review of the evidence, the expert panel formulated recommendations that addressed various aspects of postoperative pain management, including preoperative education, perioperative pain management planning, use of different pharmacological and nonpharmacological modalities, organizational policies, and transition to outpatient care. The recommendations are based on the underlying premise that optimal management begins in the preoperative period with an assessment of the patient and development of a plan of care tailored to the individual and the surgical procedure involved. The panel found that evidence supports the use of multimodal regimens in many situations, although the exact components of effective multi modal care will vary depending on the patient, setting, and surgical procedure. Although these guidelines are based on a systematic review of the evidence on management of postoperative pain, the panel identified numerous research gaps. Of 32 recommendations, 4 were assessed as being supported by high-quality evidence, and 11 (in the areas of patient education and perioperative planning, patient assessment, organizational structures and policies, and transitioning to outpatient care) were made on the basis of low-quality evidence. (C) 2016 by the American Pain Society C1 [Chou, Roger] Oregon Hlth & Sci Univ, Pacific Northwest Evidence Based Practice Ctr, Dept Med, Portland, OR 97201 USA. [Chou, Roger] Oregon Hlth & Sci Univ, Pacific Northwest Evidence Based Practice Ctr, Dept Med Informat & Clin Epidemiol, Portland, OR 97201 USA. [Gordon, Debra B.] Univ Washington, Dept Anesthesiol & Pain Med, Seattle, WA 98195 USA. [de Leon-Casasola, Oscar A.] Roswell Pk Canc Inst, Dept Anesthesiol & Pain Med, Buffalo, NY 14263 USA. [de Leon-Casasola, Oscar A.] SUNY Buffalo, Sch Med & Biomed Sci, Buffalo, NY 14260 USA. [Rosenberg, Jack M.] Univ Michigan, Vet Integrated Serv Network, Dept Vet Affairs, Ann Arbor, MI 48109 USA. [Rosenberg, Jack M.] Univ Michigan, Dept Phys Med, Ann Arbor, MI 48109 USA. [Rosenberg, Jack M.] Univ Michigan, Dept Rehabil & Anesthesiol, Ann Arbor, MI 48109 USA. [Bickler, Stephen] Univ Calif San Diego, Pediat Surg, San Diego, CA 92103 USA. [Brennan, Tim] Univ Iowa Hosp & Clin, Dept Anesthesia, Iowa City, IA 52242 USA. [Carter, Todd] Univ Cincinnati, Dept Anesthesia, Cincinnati, OH USA. [Cassidy, Carla L.] Vet Hlth Adm, Dept Vet Affairs, Washington, DC USA. [Chittenden, Eva Hall] Massachusetts Gen Hosp, Dept Palliat Care, Boston, MA 02114 USA. [Degenhardt, Ernest] United States Army Med Command, Qual Management Div, San Antonio, TX USA. [Griffith, Scott] Walter Reed Army Med Ctr, Crit Care Med, Bethesda, MD USA. [Manworren, Renee] Univ Connecticut, Sch Med, Dept Pediat, Mansfield, CT USA. [McCarberg, Bill] Amer Acad Pain Med, San Diego, CA USA. [Montgomery, Robert] Univ Colorado, Dept Anesthesiol, Denver, CO 80202 USA. [Murphy, Jamie; Wu, Christopher L.] Johns Hopkins Univ, Dept Anesthesiol & Crit Care Med, Baltimore, MD USA. [Perkal, Melissa F.] Vet Affairs Med Ctr, Dept Surg, West Haven, CT USA. [Suresh, Santhanam] Childrens Hosp Chicago, Dept Pediat Anesthesia, Chicago, IL USA. [Sluka, Kathleen] Univ Iowa, Dept Phys Therapy & Rehabil, Iowa City, IA USA. [Strassels, Scott] Univ Texas Austin, Coll Pharm, Austin, TX 78712 USA. [Thirlby, Richard] Virginia Mason Med Ctr, Bariatr Weight Loss Surg Ctr, Seattle, WA 98101 USA. [Viscusi, Eugene] Thomas Jefferson Univ, Dept Anesthesiol, Philadelphia, PA 19107 USA. [Walco, Gary A.] Seattle Childrens Hosp, Dept Anesthesiol & Pain Med, Seattle, WA USA. [Warner, Lisa] Dept Veteran Affairs, Phoenix, AZ USA. [Weisman, Steven J.] Childrens Hosp Wisconsin, Dept Anesthesiol, Wauwatosa, WI USA. RP Chou, R (reprint author), 3181 SW Sam Jackson Pk Rd,Mail Code BICC, Portland, OR 97239 USA. EM chour@ohsu.edu FU American Pain Society FX Funding for this guideline was provided by the American Pain Society. The guideline was submitted for approval by the partnering organizations, but the content of the guideline is the sole responsibility of the authors and panel members. NR 320 TC 33 Z9 39 U1 11 U2 27 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND SN 1526-5900 J9 J PAIN JI J. Pain PD FEB PY 2016 VL 17 IS 2 BP 131 EP 157 DI 10.1016/j.jpain.2015.12.008 PG 27 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA DD7NO UT WOS:000370111600001 PM 26827847 ER PT J AU Nagai, T Clark, NC Abt, JP Sell, TC Heebner, NR Smalley, BW Wirt, MD Lephart, SM AF Nagai, Takashi Clark, Nicholas C. Abt, John P. Sell, Timothy C. Heebner, Nicholas R. Smalley, Brian W. Wirt, Michael D. Lephart, Scott M. TI The Effect of Target Position on the Accuracy of Cervical-Spine-Rotation Active Joint-Position Sense SO JOURNAL OF SPORT REHABILITATION LA English DT Article DE proprioception; neck; helicopter pilots ID CERVICOCEPHALIC KINESTHETIC SENSIBILITY; NECK PAIN; SENSORIMOTOR SYSTEM; WHIPLASH INJURY; MUSCLE-SPINDLES; MOTION; MANAGEMENT; RANGE; HEAD; PROPRIOCEPTION AB Context: The cervical spine can be divided into upper and lower units, each making a different contribution to the magnitude of rotation and proprioception. However, few studies have examined the effect of the cervical rotation positions on proprioception. Objective: To compare cervical-spine rotation active joint-position sense (AJPS) near midrange of motion (mid-ROM; 30 degrees) and near end-ROM (60 degrees). Design: Cross-sectional study. Setting: Human performance research laboratory. Participants: 53 military helicopter pilots (age 28.4 +/- 6.2 y, height 175.3 +/- 9.3 cm, weight 80.1 +/- 11.8 kg). Main Outcome Measures: A motion-analysis system was used to record cervical-rotation kinematics. Subjects sat in a chair wearing a headband and blindfold. First, they actively rotated the head right or left to a target position (30 degrees/60 degrees), with real-time verbal cues provided by the tester. Subjects held the target position for 5 s and then returned to the start position. After this, they replicated the target position as closely as possible. Five trials were performed in both directions to both target positions (R30/R60/L30/L60). Order of direction/position was randomized. The difference between target and replicated positions was calculated and defined as absolute error (AE), and the mean of 5 trials was used for analyses. Wilcoxon signed-ranks tests were used to compare AJPS at the different target positions (P <.0125 with Bonferroni adjustments). Results: End-ROM AEs were significantly more accurate than mid-ROM AEs (P =.001). Conclusion: Cervical-spine-rotation AJPS is more accurate near end-ROM than mid-ROM. Both target positions should be used to examine cervical-spine-rotation AJPS of both the upper and lower units. C1 [Nagai, Takashi] Univ Pittsburgh, Dept Sports Med & Nutr, Pittsburgh, PA USA. [Clark, Nicholas C.] St Marys Univ, Sch Sport Hlth & Appl Sci, London, England. [Abt, John P.; Heebner, Nicholas R.; Lephart, Scott M.] Univ Kentucky, Coll Hlth Sci, Lexington, KY USA. [Sell, Timothy C.] Duke Univ, Dept Orthopaed Surg, Durham, NC USA. [Smalley, Brian W.] US Army Aeromed Act, Ft Rucker, AL USA. [Wirt, Michael D.] US Army Inst Surg Res, Ft Sam Houston, TX USA. RP Nagai, T (reprint author), Univ Pittsburgh, Dept Sports Med & Nutr, Pittsburgh, PA USA. EM tnagai@pitt.edu FU US Army Medical Research and Materiel Command [W81XWH-11-2-0097] FX This work was supported by the US Army Medical Research and Materiel Command under Award No. W81XWH-11-2-0097. Opinions, interpretations, conclusions, and recommendations are those of the author and are not necessarily endorsed by the US Army. NR 48 TC 0 Z9 0 U1 1 U2 6 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA SN 1056-6716 EI 1543-3072 J9 J SPORT REHABIL JI J. Sport Rehabil. PD FEB PY 2016 VL 25 IS 1 BP 58 EP 63 DI 10.1123/jsr.2014-0263 PG 6 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA DD7OY UT WOS:000370115200009 PM 26836358 ER PT J AU Tavakoly, AA Maidment, DR McClelland, JW Whiteaker, T Yang, ZL Griffin, C David, CH Meyer, L AF Tavakoly, Ahmad A. Maidment, David R. McClelland, James W. Whiteaker, Tim Yang, Zong-Liang Griffin, Claire David, Cedric H. Meyer, Lisa TI A GIS FRAMEWORK FOR REGIONAL MODELING OF RIVERINE NITROGEN TRANSPORT: CASE STUDY, SAN ANTONIO AND GUADALUPE BASINS SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION LA English DT Article DE total nitrogen; geographic information system; river networks; nonpoint source pollution; surface water hydrology; NHDPlus; Routing Application for Parallel computation of Discharge ID LAND-USE CHANGE; GULF-OF-MEXICO; WATER-QUALITY; NORTHEASTERN USA; UNITED-STATES; EXPORT; STREAMS; FLOW; NUTRIENTS; NETWORKS AB This article presents a framework for integrating a regional geographic information system (GIS)-based nitrogen dataset (Texas Anthropogenic Nitrogen Dataset, TX-ANB) and a GIS-based river routing model (Routing Application for Parallel computation of Discharge) to simulate steady-state riverine total nitrogen (TN) transport in river networks containing thousands of reaches. A two-year case study was conducted in the San Antonio and Guadalupe basins during dry and wet years (2008 and 2009, respectively). This article investigates TN export in urbanized (San Antonio) vs. rural (Guadalupe) drainage basins and considers the effect of reservoirs on TN transport. Simulated TN export values are within 10 percent of measured export values for selected stations in 2008 and 2009. Results show that in both years the San Antonio basin contributed a larger quantity than the Guadalupe basin of delivered TN to the coastal ocean. The San Antonio basin is affected by urban activities including point sources, associated with the city of San Antonio, in addition to greater agricultural activities. The Guadalupe basin lacks major metropolitan areas and is dominated by rangeland, rather than fertilized agricultural fields. Both basins delivered more TN to coastal waters in 2009 than in 2008. Furthermore, TN removal in the San Antonio and Guadalupe basins is inversely related to stream orders: the higher the order the more TN delivery (or the less TN removal). C1 [Tavakoly, Ahmad A.] US Army, Corps Engineers, Coastal & Hydraul Lab, River Engn Branch, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. [Maidment, David R.] Univ Texas Austin, Dept Civil Architectural & Environm Engn, Austin, TX 78712 USA. [Whiteaker, Tim] Univ Texas Austin, Ctr Res Water Resources, Austin, TX 78712 USA. [Yang, Zong-Liang] Univ Texas Austin, Jackson Sch Geosci, Austin, TX 78712 USA. [McClelland, James W.; Griffin, Claire] Univ Texas Austin, Dept Marine Sci, Port Aransas, TX 78373 USA. [David, Cedric H.] CALTECH, Jet Prop Lab, 4800 Oak Grove Dr, Pasadena, CA 91109 USA. [Meyer, Lisa] Hilcorp Energy Co, Houston, TX 77002 USA. RP Tavakoly, AA (reprint author), US Army, Corps Engineers, Coastal & Hydraul Lab, River Engn Branch, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM ahmad.a.tavakoly@erdc.dren.mil RI Yang, Zong-Liang/B-4916-2011; McClelland, James/C-5396-2008; OI McClelland, James/0000-0001-9619-8194; Tavakoly, Ahmad A./0000-0002-2163-2627 FU NASA Interdisciplinary Science Project [NNX11AE42G]; USACE Coastal and Hydraulics Laboratory; Jet Propulsion Laboratory; California Institute of Technology FX This project was partially funded by the NASA Interdisciplinary Science Project NNX11AE42G and USACE Coastal and Hydraulics Laboratory. The locations and data on wastewater treatment plants and industrial facilities were obtained from the Discharge Monitoring Report (DMR) Pollutant Loading Tool. The river maps were derived from the NHDPlus dataset. Cedric H. David is supported by the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration. We thank the editor-in-chief and two anonymous reviewers for their valuable comments that helped improved the original version of this manuscript. NR 51 TC 1 Z9 1 U1 4 U2 13 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1093-474X EI 1752-1688 J9 J AM WATER RESOUR AS JI J. Am. Water Resour. Assoc. PD FEB PY 2016 VL 52 IS 1 BP 1 EP 15 DI 10.1111/1752-1688.12355 PG 15 WC Engineering, Environmental; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA DD5XV UT WOS:000369999100001 ER PT J AU Hendrickx, JMH Allen, RG Brower, A Byrd, AR Hong, SH Ogden, FL Pradhan, NR Robison, CW Toll, D Trezza, R Umstot, TG Wilson, JL AF Hendrickx, Jan M. H. Allen, Richard G. Brower, Al Byrd, Aaron R. Hong, Sung-ho Ogden, Fred L. Pradhan, Nawa Raj Robison, Clarence W. Toll, David Trezza, Ricardo Umstot, Todd G. Wilson, John L. TI BENCHMARKING OPTICAL/THERMAL SATELLITE IMAGERY FOR ESTIMATING EVAPOTRANSPIRATION AND SOIL MOISTURE IN DECISION SUPPORT TOOLS SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION LA English DT Article DE soil moisture; evapotranspiration; GSSHA; SEBAL; METRIC; DPWM; distributed hydrologic modeling; optical/thermal satellite imagery; Landsat; MODIS; groundwater recharge; water management; hydrograph ID ENERGY BALANCE ALGORITHM; CROP COEFFICIENT METHOD; LATENT-HEAT FLUXES; ROOT WATER-UPTAKE; OPTICAL IMAGERY; MAPPING EVAPOTRANSPIRATION; ESTIMATING EVAPORATION; MODEL; SURFACE; LAND AB Generally, one expects evapotranspiration (ET) maps derived from optical/thermal Landsat and MODIS satellite imagery to improve decision support tools and lead to superior decisions regarding water resources management. However, there is lack of supportive evidence to accept or reject this expectation. We benchmark three existing hydrologic decision support tools with the following benchmarks: annual ET for the ET Toolbox developed by the United States Bureau of Reclamation, predicted rainfall-runoff hydrographs for the Gridded Surface/Subsurface Hydrologic Analysis model developed by the U.S. Army Corps of Engineers, and the average annual groundwater recharge for the Distributed Parameter Watershed Model used by Daniel B. Stephens & Associates. The conclusion of this benchmark study is that the use of NASA/USGS optical/thermal satellite imagery can considerably improve hydrologic decision support tools compared to their traditional implementations. The benefits of improved decision making, resulting from more accurate results of hydrologic support systems using optical/thermal satellite imagery, should substantially exceed the costs for acquiring such imagery and implementing the remote sensing algorithms. In fact, the value of reduced error in estimating average annual groundwater recharge in the San Gabriel Mountains, California alone, in terms of value of water, may be as large as $1 billion, more than sufficient to pay for one new Landsat satellite. C1 [Hendrickx, Jan M. H.; Wilson, John L.] New Mexico Inst Min & Technol, Dept Earth & Environm Sci, 801 Leroy Pl, Socorro, NM 87801 USA. [Allen, Richard G.; Robison, Clarence W.; Trezza, Ricardo] Univ Idaho, Kimberly Res & Extens Ctr, Kimberly, ID 83341 USA. [Brower, Al] US Bur Reclamat, Water & Environm Resources Div, Denver, CO 80225 USA. [Byrd, Aaron R.; Pradhan, Nawa Raj] US Army, Corps Engineers, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [Hong, Sung-ho] Murray State Univ, Dept Geosci, Murray, KY 42071 USA. [Ogden, Fred L.] Univ Wyoming, Water Resources Environm Sci & Engn, Laramie, WY 82071 USA. [Toll, David] NASA, Goddard Space Flight Ctr, Hydrol Sci Lab, Greenbelt, MD 20771 USA. [Umstot, Todd G.] Daniel B Stephens & Associates Inc, Albuquerque, NM 87109 USA. RP Hendrickx, JMH (reprint author), New Mexico Inst Min & Technol, Dept Earth & Environm Sci, 801 Leroy Pl, Socorro, NM 87801 USA. EM hendrick@nmt.edu FU NASA [NNA06CN01A]; Idaho Agricultural Experiment Station FX We acknowledge financial support by NASA under Cooperative Agreement #NNA06CN01A, support by the Idaho Agricultural Experiment Station, and support by the USGS Landsat Science Team (Allen). NR 152 TC 2 Z9 2 U1 7 U2 18 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1093-474X EI 1752-1688 J9 J AM WATER RESOUR AS JI J. Am. Water Resour. Assoc. PD FEB PY 2016 VL 52 IS 1 BP 89 EP 119 DI 10.1111/1752-1688.12371 PG 31 WC Engineering, Environmental; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA DD5XV UT WOS:000369999100007 ER PT J AU Aboudara, M Hicks, B Cuadrado, D Mahoney, PF Docekal, J AF Aboudara, Matthew Hicks, B. Cuadrado, D. Mahoney, P. F. Docekal, J. TI Impact of primary blast lung injury during combat operations in Afghanistan SO JOURNAL OF THE ROYAL ARMY MEDICAL CORPS LA English DT Letter C1 [Aboudara, Matthew] Tripler Army Med Ctr, Pulm Clin, MCHK DM P, Jarrett White Rd, Honolulu, HI 96859 USA. [Hicks, B.] William Beaumont Army Med Ctr, Dept Radiol, El Paso, TX 79920 USA. [Cuadrado, D.] Madigan Army Med Ctr, Dept Cardiothorac Surg, Tacoma, WA 98431 USA. [Mahoney, P. F.] Royal Ctr Def Med, Dept Mil Anaesthesia & Crit Care, Birmingham, W Midlands, England. [Docekal, J.] Tripler Army Med Ctr, Dept Internal Med, Honolulu, HI 96859 USA. RP Aboudara, M (reprint author), Tripler Army Med Ctr, Pulm Clin, MCHK DM P, Jarrett White Rd, Honolulu, HI 96859 USA. EM maboudara23@gmail.com NR 2 TC 0 Z9 0 U1 1 U2 3 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0035-8665 EI 2052-0468 J9 J ROY ARMY MED CORPS JI J. R. Army Med. Corps PD FEB PY 2016 VL 162 IS 1 BP 75 EP 75 DI 10.1136/jramc-2015-000481 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA DD6BV UT WOS:000370009600017 PM 26092970 ER PT J AU Tolisano, AM Song, SJA Cable, BB AF Tolisano, Anthony M. Song, Sungjin A. Cable, Benjamin B. TI Author Self-Citation in the Otolaryngology Literature: A Pilot Study SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article DE citation analysis; impact factor; h-index ID OTORHINOLARYNGOLOGY JOURNALS; H-INDEX; IMPACT; OUTPUT AB Objective To determine the prevalence of author self-citation in the field of otolaryngology. Study Design and Setting A retrospective review of bibliographic references in 5 otolaryngology journals. Subjects and Methods Five high-impact otolaryngology journals were reviewed over a 3-month period between January and March 2014 to identify the pattern of author self-citations. Data included study type, otolaryngology topic, authorship, total citations, author self-citations, and country of origin. Results Nearly two-thirds of articles contained at least 1 self-citation, with an average of 2.6 self-citations per article. Self-citations represented nearly 10% of total citations. Articles with at least 1 self-citation had more authors (5.8 vs 4.9, P < .01) and more citations (30.4 vs 22.2, P < .01) per article than did those without self-citations. There was no difference in self-citation practices between articles originating within the United States and abroad (P = .65). Last authors were the most frequent self-citers and were more likely than lead authors to cite themselves (P < .01). Original reports contained the highest percentage of self-citations per article as compared with reviews and case reports (P < .01). Conclusion Author self-citation in the otolaryngology literature is common and compares similarly to other medical specialties previously studied. Self-citation should not be considered inappropriate, as it is often done to expand on earlier research. Nevertheless, editors, researchers, and readers should be aware of this increasingly recognized phenomenon and its associated potential implications to the process of scientific inquiry. C1 [Tolisano, Anthony M.; Song, Sungjin A.; Cable, Benjamin B.] Tripler Army Med Ctr, Dept Otolaryngol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. RP Tolisano, AM (reprint author), Tripler Army Med Ctr, Dept Otolaryngol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM anthony.m.tolisano.mil@mail.mil NR 17 TC 1 Z9 1 U1 2 U2 2 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0194-5998 EI 1097-6817 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD FEB PY 2016 VL 154 IS 2 BP 282 EP 286 DI 10.1177/0194599815616111 PG 5 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA DD5VB UT WOS:000369991600014 PM 26556466 ER PT J AU Cardenas, JC Cap, AP Swartz, MD Huby, MD Baer, LA Matijevic, N Cotton, BA Holcomb, JB Wade, CE AF Cardenas, Jessica C. Cap, Andrew P. Swartz, Michael D. Huby, Maria del Pilar Baer, Lisa A. Matijevic, Nena Cotton, Bryan A. Holcomb, John B. Wade, Charles E. TI PLASMA RESUSCITATION PROMOTES COAGULATION HOMEOSTASIS FOLLOWING SHOCK-INDUCED HYPERCOAGULABILITY SO SHOCK LA English DT Article DE Antithrombin; hemorrhagic shock; hemostasis; resuscitation; thrombin; trauma ID DAMAGE CONTROL RESUSCITATION; FRESH-FROZEN PLASMA; THROMBIN GENERATION; HEMORRHAGIC-SHOCK; IN-VITRO; HEMODILUTION; TRANSFUSION; TRAUMA; HEMOSTASIS; COAGULOPATHY AB Background:Increased thrombin generation in injured patients possibly contributes to early consumption of coagulation factors, exacerbating hemorrhage. Identifying optimal resuscitation products for restoring plasma homeostasis following injury is important for improving management of these patients.Objectives:To determine the effects of crystalloid versus plasma resuscitation on thrombin generation in a rat model of trauma and hemorrhagic shock (HS).Patients/Methods:Rats were subjected to trauma and HS followed by resuscitation with Lactated Ringer's solution (LR) or fresh frozen plasma (FFP). Blood was collected at baseline, decompensation, and 3-h post-resuscitation. Thrombin generation was measured by calibrated automated thrombogram and antithrombin III (AT) by ELISA. In a prospective observational study, admission blood samples were collected on highest-level activation trauma patients and diluted with LR or FFP for thrombin generation analysis.Results:Resuscitation with LR resulted in persistent hypercoagulability; however, FFP resuscitation reversed this hypercoagulability to baseline thrombin generation or below. Plasma AT levels decreased following HS and remained low in rats receiving LR, but were corrected in rats receiving FFP. Similarly, in trauma patient plasma LR increased thrombin generation while FFP reduced it. However, results with AT-deficient plasma dilution were similar to LR. In patients with admission hypocoagulability, FFP slightly increased thrombin generation.Conclusions:HS in rats is associated with increased thrombin generation and resuscitation with FFP, not LR, reverses hypercoagulability. Dilution of trauma patient plasma with LR or FFP yielded similar results; however, the modulatory effects of FFP were attenuated when AT was absent. Importantly, FFP reduced thrombin generation in hypercoagulable patient plasma, but slightly increased thrombin generation in hypocoagulable patient plasma. Thus, FFP restores hemostatic balance following trauma and HS which is, in part, by delivering AT. C1 [Cardenas, Jessica C.; Cap, Andrew P.; Huby, Maria del Pilar; Baer, Lisa A.; Matijevic, Nena; Cotton, Bryan A.; Holcomb, John B.; Wade, Charles E.] Univ Texas Hlth Sci Ctr Houston, Dept Surg, Houston, TX 77030 USA. [Cardenas, Jessica C.; Swartz, Michael D.; Huby, Maria del Pilar; Baer, Lisa A.; Matijevic, Nena; Cotton, Bryan A.; Holcomb, John B.; Wade, Charles E.] Univ Texas Hlth Sci Ctr Houston, Ctr Translat Injury Res, Houston, TX 77030 USA. [Cap, Andrew P.] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Swartz, Michael D.] Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Dept Biostat, Houston, TX 77030 USA. RP Cardenas, JC (reprint author), Univ Texas Hlth Sci Ctr Houston, 6431 Fannin St,MSB 5-030, Houston, TX 77030 USA. EM Jessica.C.Cardenas@uth.tmc.edu FU NHLBI [1F32HL120549-01A1]; State of Texas Emerging Technology Fund; University of Texas Health Science Center's Center for Translational Injury Research FX Support for this work was provided by NHLBI 1F32HL120549-01A1 to J.C.C., The State of Texas Emerging Technology Fund, and the University of Texas Health Science Center's Center for Translational Injury Research. NR 34 TC 2 Z9 2 U1 2 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD FEB PY 2016 VL 45 IS 2 BP 166 EP 173 DI 10.1097/SHK.0000000000000504 PG 8 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA DD5UB UT WOS:000369988900009 PM 26529664 ER PT J AU Reddoch, KM Montgomery, RK Rodriguez, AC Meledeo, MA Pidcoke, HF Ramasubramanian, AK Cap, AP AF Reddoch, Kristin M. Montgomery, Robbie K. Rodriguez, Armando C. Meledeo, M. Adam Pidcoke, Heather F. Ramasubramanian, Anand K. Cap, Andrew P. TI ENDOTHELIUM-DERIVED INHIBITORS EFFICIENTLY ATTENUATE THE AGGREGATION AND ADHESION RESPONSES OF REFRIGERATED PLATELETS SO SHOCK LA English DT Article DE Apheresis platelets; cold storage; hemostatic function; inhibition ID NITRIC-OXIDE; THROMBIN GENERATION; FACTOR-V; PROSTACYCLIN; STORAGE; CGMP; COLLAGEN; ASPIRIN; CELLS; ASSAY AB Refrigeration of platelets (4 degrees C) provides the possibility of improving transfusion practice over the current standard-of-care, room temperature (RT) storage. However, the increased level of platelet activation observed at 4 degrees C in vitro is cause for concern of uncontrolled thrombosis in vivo. In this study, we assessed the safety of 4 degrees C-stored platelets by evaluating their response to physiologic inhibitors prostacyclin (PGI(2)) and nitric oxide (NO). Apheresis platelets were collected from healthy donors (n=4) and tested on Day 1 (fresh) or Day 5 (RT- and 4 degrees C-stored) after treatment with PGI(2) and NO or not for: thrombin generation; factor V (FV) activity; intracellular free calcium, cAMP and cGMP; ATP release; TRAP-induced activation; aggregation to ADP, collagen, and TRAP, and adhesion to collagen under arterial flow. Data were analyzed using two-way ANOVA and post-hoc Tukey test for multiple comparisons, with significance set at P<0.05. Treatment with inhibitors increased intracellular cAMP and cGMP levels in fresh and stored platelets. Thrombin generation was significantly accelerated in stored platelets consistent with increased factor V levels, PS exposure, CD62P expression, intracellular free calcium, and ATP release. While treatment with inhibitors did not attenuate thrombin generation in stored platelets, activation, aggregation, and adhesion responses were inhibited by both PGI(2) and NO in 4 degrees C-stored platelets. In contrast, though RT-stored platelets were activated, they did not adhere or aggregate in response to agonists. Thus, refrigerated platelets maintain their intracellular machinery, are responsive to agonists and platelet function inhibitors, and perform hemostatically better than RT-stored platelets. C1 [Reddoch, Kristin M.; Montgomery, Robbie K.; Rodriguez, Armando C.; Meledeo, M. Adam; Ramasubramanian, Anand K.] Univ Texas San Antonio, Dept Biomed Engn, San Antonio, TX 78256 USA. [Reddoch, Kristin M.; Pidcoke, Heather F.; Cap, Andrew P.] US Army, Inst Surg Res, Coagulat & Blood Res Program, Ft Sam Houston, TX 78234 USA. RP Ramasubramanian, AK (reprint author), Univ Texas San Antonio, Dept Biomed Engn, San Antonio, TX 78256 USA.; Cap, AP (reprint author), US Army, Inst Surg Res, Coagulat & Blood Res Program, Ft Sam Houston, TX 78234 USA.; Cap, AP (reprint author), US Army, Inst Surg Res, Blood Res Program, Ft Sam Houston, TX 78234 USA. EM anand.rama-subramanian@utsa.edu; andrew.p.cap.mil@mail.mil FU Department of Defense [W81XWH-13-P-0146]; American Heart Association [14PRE19580011] FX This study was supported by a contract from the Department of Defense (W81XWH-13-P-0146) and by American Heart Association Grant 14PRE19580011 (Kristin Reddoch). NR 35 TC 2 Z9 2 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD FEB PY 2016 VL 45 IS 2 BP 220 EP 227 DI 10.1097/SHK.0000000000000493 PG 8 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA DD5UB UT WOS:000369988900015 PM 26555740 ER PT J AU Khraiwesh, M Leed, S Roncal, N Johnson, J Sciotti, R Smith, P Read, L Paris, R Hudson, T Hickman, M Grogl, M AF Khraiwesh, Mozna Leed, Susan Roncal, Norma Johnson, Jacob Sciotti, Richard Smith, Philip Read, Lisa Paris, Robert Hudson, Thomas Hickman, Mark Grogl, Max TI Antileishmanial Activity of Compounds Derived from the Medicines for Malaria Venture Open Access Box against Intracellular Leishmania major Amastigotes SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID CUTANEOUS LEISHMANIASIS; IN-VITRO; AXENIC AMASTIGOTES; COLORIMETRIC ASSAY; GENE-EXPRESSION; DRUG DISCOVERY; AMPHOTERICIN-B; MACROPHAGES; IDENTIFICATION; PROMASTIGOTES AB Leishmaniasis is a complex tropical disease caused by kinetoplastid parasitic protozoa of the genus Leishmania and is transmitted by the sand fly insect vector. Cutaneous leishmaniasis (CL) is the most common form of this disease, and CL infections often result in serious skin lesions and scars. CL remains a public health problem in many endemic countries worldwide because of the absence of effective, safe, and cost-effective drugs for treatment. One of the strategies we chose to use to find novel chemical entities worthy of further development as antileishmanials involved screening synthetic and natural products libraries. In our study, we developed a Leishmania major intracellular amastigote assay that uses the activity of luciferase as a measure of parasite proliferation and used this assay to screen a collection of 400 compounds obtained from Medicines for Malaria Venture (MMV) for their antileishmanial activity. Our results showed that 14 compounds identified by MMV as antimalarial drugs have antileishmanial activity and can potentially be optimized for CL drug development. C1 [Khraiwesh, Mozna] Walter Reed Army Inst Res, Div Expt Therapeut, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. Madigan Army Med Ctr, Dept Clin Invest, Tacoma, WA 98431 USA. Walter Reed Army Inst Res, Mil Malaria Res Program, Silver Spring, MD USA. RP Khraiwesh, M (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM mozna.h.khraiwesh.ctr@mail.mil NR 39 TC 2 Z9 2 U1 1 U2 4 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD FEB PY 2016 VL 94 IS 2 BP 340 EP 347 DI 10.4269/ajtmh.15-0448 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA DC8JK UT WOS:000369465500016 PM 26503273 ER PT J AU Kardouni, JR AF Kardouni, Joseph R. TI IMAGES IN EMERGENCY MEDICINE DIAGNOSIS: Distal radius fracture SO ANNALS OF EMERGENCY MEDICINE LA English DT Editorial Material ID EPIDEMIOLOGY C1 [Kardouni, Joseph R.] US Army Res Inst Environm Med, Mil Performance Div, Natick, MA USA. RP Kardouni, JR (reprint author), US Army Res Inst Environm Med, Mil Performance Div, Natick, MA USA. NR 4 TC 0 Z9 0 U1 0 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD FEB PY 2016 VL 67 IS 2 BP 165 EP + DI 10.1016/j.annemergmed.2015.06.004 PG 2 WC Emergency Medicine SC Emergency Medicine GA DC3MW UT WOS:000369124400006 PM 26801377 ER PT J AU Park, S Lee, LS Medina, VF Zull, A Waisner, S AF Park, Saerom Lee, Linda S. Medina, Victor F. Zull, Aaron Waisner, Scott TI Heat-activated persulfate oxidation of PFOA, 6:2 fluorotelomer sulfonate, and PFOS under conditions suitable for in-situ groundwater remediation SO CHEMOSPHERE LA English DT Article DE PFOA; PFOS; 6:2 FTSA; Heat-activated persulfate; Oxidation ID PERFLUOROOCTANOIC ACID PFOA; PERFLUOROCARBOXYLIC ACIDS; EFFICIENT DECOMPOSITION; PERFLUORINATED SURFACTANTS; HOT-WATER; KINETICS; DEGRADATION; FLUOROCHEMICALS; TRANSFORMATION; MECHANISM AB PFOA (perfluorooctanoic acid) oxidation (0.121-6.04 mu M) by heat-activated persulfate was evaluated at 20-60 degrees C with 4.2-84 mM S2O82- and in the presence of soluble fuel components to assess feasibility for in-situ remediation of groundwater. 6:2 fluorotelomer sulfonic acid/sulfonate (6:2 FTSA) and PFOS (perfluorooctanesulfonic acid) persulfate oxidation was also evaluated in a subset of conditions given their co-occurrence at many sites. High performance liquid chromatography electron spray tandem mass spectrometry was used for organic analysis and fluoride was measured using a fluoride-specific electrode. PFOA pseudo-1st order transformation rates (k(1,PFOA)) increased with increasing temperature (half-lives from 0.1 to 7 d for 60 to 30 degrees C) sequentially removing CF2 groups ('unzipping') to shorter chain perfluoroalkyl carboxylic acids (PFCAs) and F. At 50 degrees C, a 5-fold increase in S2O82- led to a 5-fold increase in k(1,PFOA) after which self-scavenging by sulfate radicals decreased the relative rate of increase with more S2O82-. Benzene, toluene, ethylbenzene and xylene did not affect k(1,PFOA) even at 40 times higher molar concentrations than PFOA. A modeling approach to explore pathways strongly supported that for 6:2 FTSA, both the ethyl linkage and CF2-CH2 bond of 6:2 FTSA oxidize simultaneously, resulting in a ratio of similar to 25/75 PFHpA/PFHxA. The effectiveness of heat-activated S2O82- on PFOA oxidation was reduced in a soil slurry; therefore, repeated persulfate injections are required to efficiently achieve complete oxidation in the field. However, PFOS remained unaltered even at higher activation temperatures, thus limiting the sole use of heat-activated persulfate for perfluoroalkyl substances removal in the field. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Park, Saerom; Lee, Linda S.; Zull, Aaron] Purdue Univ, Dept Agron Ecol Sci & Engn, W Lafayette, IN 47907 USA. [Medina, Victor F.; Waisner, Scott] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Lee, LS (reprint author), Purdue Univ, Ecol Sci & Engn Interdisciplinary Grad Program, W Lafayette, IN 47907 USA. EM lslee@purdue.edu OI Waisner, Scott/0000-0003-4360-4712 FU Air Force Center of Engineering and Environment (AFCEE) [BAA715, EL-3] FX This work was funded by the Air Force Center of Engineering and Environment (AFCEE, #BAA715, EL-3). We also wish to acknowledge Stephen Sassman and Chloe De Perre for their analytical chemistry support. NR 43 TC 2 Z9 3 U1 38 U2 103 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 EI 1879-1298 J9 CHEMOSPHERE JI Chemosphere PD FEB PY 2016 VL 145 BP 376 EP 383 DI 10.1016/j.chemosphere.2015.11.097 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA DC4MZ UT WOS:000369196300048 PM 26692515 ER PT J AU Costanzo, MR Negoianu, D Jaski, BE Bart, BA Heywood, JT Anand, IS Smelser, JM Kaneshige, AM Chomsky, DB Adler, ED Haas, GJ Watts, JA Nabut, JL Schollmeyer, MP Fonarow, GC AF Costanzo, Maria Rosa Negoianu, Daniel Jaski, Brian E. Bart, Bradley A. Heywood, James T. Anand, Inder S. Smelser, James M. Kaneshige, Alan M. Chomsky, Don B. Adler, Eric D. Haas, Garrie J. Watts, James A. Nabut, Jose L. Schollmeyer, Michael P. Fonarow, Gregg C. TI Aquapheresis Versus Intravenous Diuretics and Hospitalizations for Heart Failure SO JACC-HEART FAILURE LA English DT Article DE aquapheresis; congestion; fluid overload; heart failure; hospitalizations; loop diuretics; worsening renal function ID CONTINUOUS ULTRAFILTRATION; CARDIORENAL SYNDROME; TRIAL; FLUID AB OBJECTIVES The AVOID-HF (Aquapheresis versus Intravenous Diuretics and Hospitalization for Heart Failure) trial tested the hypothesis that patients hospitalized for HF treated with adjustable ultrafiltration (AUF) would have a longer time to first HF event within 90 days after hospital discharge than those receiving adjustable intravenous loop diuretics (ALD). BACKGROUND Congestion in hospitalized heart failure (HF) patients portends unfavorable outcomes. METHODS The AVOID-HF trial, designed as a multicenter, 1-to-1 randomized study of 810 hospitalized HF patients, was terminated unilaterally and prematurely by the sponsor (Baxter Healthcare, Deerfield, Illinois) after enrollment of 224 patients (27.5%). Aquadex FlexFlow System (Baxter Healthcare) was used for AUF. A Clinical Events Committee, blinded to the randomized treatment, adjudicated whether 90-day events were due to HF. RESULTS A total of 110 patients were randomized to AUF and 114 to ALD. Baseline characteristics were similar. Estimated days to first HF event for the AUF and ALD group were, respectively, 62 and 34 (p = 0.106). At 30 days, compared with the ALD group, the AUF group had fewer HF and cardiovascular events. Renal function changes were similar. More AUF patients experienced an adverse effect of special interest (p = 0.018) and a serious study product-related adverse event (p = 0.026). The 90-day mortality was similar. CONCLUSIONS Compared with the ALD group, the AUF group trended toward a longer time to first HF event within 90 days and fewer HF and cardiovascular events. More patients in the AUF group experienced special interest or serious product-related adverse event. Due to the trial's untimely termination, additional AUF investigation is warranted. (C) 2016 by the American College of Cardiology Foundation. C1 [Costanzo, Maria Rosa] Edward Heart Hosp, Advocate Heart Inst, 4th Floor,801 South Washington St, Naperville, IL 60566 USA. [Negoianu, Daniel] Univ Penn, Med Ctr, Div Nephrol, Philadelphia, PA 19104 USA. [Jaski, Brian E.] Sharp Mem Hosp & Rehabil Ctr, San Diego Cardiac Ctr, San Diego, CA USA. [Bart, Bradley A.] Hennepin Cty Med Ctr, Dept Med, Div Cardiol, Minneapolis, MN 55415 USA. [Heywood, James T.] Scripps Clin, Heart Failure Recovery & Res Program, San Diego, CA USA. [Anand, Inder S.] Univ Minnesota, VA Med Ctr, Minneapolis, MN USA. [Smelser, James M.] Huntsville Renal Clin, Huntsville, AL USA. [Kaneshige, Alan M.] Oklahoma Heart Inst, Tulsa, OK USA. [Chomsky, Don B.] St Thomas Heart Hosp, Nashville, TN USA. [Adler, Eric D.] Univ Calif San Diego, Div Cardiol, San Diego, CA 92103 USA. [Haas, Garrie J.] Ohio State Univ, Div Cardiol, Columbus, OH 43210 USA. [Watts, James A.] Brooke Army Med Ctr, San Antonio, TX USA. [Nabut, Jose L.; Schollmeyer, Michael P.] Baxter Healthcare Corp, Deerfield, IL 60015 USA. [Fonarow, Gregg C.] Univ Calif Los Angeles, Div Cardiol, Los Angeles, CA USA. RP Costanzo, MR (reprint author), Edward Heart Hosp, Advocate Heart Inst, 4th Floor,801 South Washington St, Naperville, IL 60566 USA. EM mariarosa.costanzo@advocatehealth.com NR 20 TC 11 Z9 13 U1 2 U2 5 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 2213-1779 EI 2213-1787 J9 JACC-HEART FAIL JI JACC-Heart Fail. PD FEB PY 2016 VL 4 IS 2 BP 95 EP 105 DI 10.1016/j.jchf.2015.08.005 PG 11 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA DC4LK UT WOS:000369192200001 PM 26519995 ER PT J AU Jutel, M Agache, I Bonini, S Burks, W Calderon, M Canonica, W Cox, LD Demoly, P Frew, AJ O'Hehir, R Kleine-Tebbe, J Muraro, A Lack, G Larenas, D Levin, M Martin, BL Nelson, H Pawankar, R Pfaar, O van Ree, R Sampson, H Sublett, JL Sugita, K Du Toit, G Werfel, T van Wijk, RG Zhang, L Akdis, M Akdis, CA AF Jutel, Marek Agache, Ioana Bonini, Sergio Burks, Wesley Calderon, Moises Canonica, Walter Cox, Linda Demoly, Pascal Frew, Antony J. O'Hehir, Robyn Kleine-Tebbe, Joerg Muraro, Antonella Lack, Gideon Larenas, Desiree Levin, Michael Martin, Bryan L. Nelson, Harald Pawankar, Ruby Pfaar, Oliver van Ree, Ronald Sampson, Hugh Sublett, James L. Sugita, Kazunari Du Toit, George Werfel, Thomas van Wijk, Roy Gerth Zhang, Luo Akdis, Muebeccel Akdis, Cezmi A. TI International Consensus on Allergen Immunotherapy II: Mechanisms, standardization, and pharmacoeconomics SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY LA English DT Article DE International consensus; allergy; immunotherapy; allergen vaccine; allergen standardization; pharmacoeconomics; cost-effectiveness; mechanisms; tolerance; marketing authorization; regulatory authorities; unmet needs ID GRASS-POLLEN IMMUNOTHERAPY; REGULATORY T-CELLS; COST-EFFECTIVENESS ANALYSIS; HISTAMINE-RECEPTOR 2; TOLL-LIKE RECEPTORS; ECONOMIC-EVALUATION; SUBLINGUAL IMMUNOTHERAPY; SYMPTOMATIC TREATMENT; IMMUNE-RESPONSES; B-CELLS AB This article continues the comprehensive international consensus (ICON) statement on allergen immunotherapy (AIT). The initial article also recently appeared in the Journal. The conclusions below focus on key mechanisms of AIT-triggered tolerance, requirements in allergen standardization, AIT cost-effectiveness, and regulatory guidance. Potential barriers to and facilitators of the use of AIT are described in addition to future directions. International allergy specialists representing the European Academy of Allergy and Clinical Immunology; the American Academy of Allergy, Asthma & Immunology; the American College of Allergy, Asthma and Immunology; and the World Allergy Organization critically reviewed the existing literature and prepared this summary of recommendations for best AIT practice. The authors contributed equally and reached consensus on the statements presented herein. C1 [Jutel, Marek] Wroclaw Med Univ, Dept Clin Immunol, Chalubinskiego 5, PL-50368 Wroclaw, Poland. [Jutel, Marek] ALL MED Med Res Inst, Wroclaw, Poland. [Agache, Ioana] Transylvania Univ, Fac Med, Brasov, Romania. [Bonini, Sergio] Univ Naples 2, Rome, Italy. [Bonini, Sergio] IFT CNR, Rome, Italy. [Bonini, Sergio] Expert On Secondment European Med Agcy, London, England. [Burks, Wesley] Univ N Carolina, Dept Pediat, Chapel Hill, NC USA. [Calderon, Moises] Univ London Imperial Coll Sci Technol & Med, Sect Allergy & Clin Immunol, Natl Heart & Lung Inst, Royal Brompton Hosp, London SW7 2AZ, England. [Canonica, Walter] DIMI Univ Genoa, Allergy & Resp Dis Clin, IRCCS AOU San Martino, Genoa, Italy. [Cox, Linda] Ctr Asthma & Allergy, Ft Lauderdale, FL USA. [Demoly, Pascal] Univ Hosp Montpellier, INSERM, U657, Montpellier, France. [Frew, Antony J.] Royal Sussex Cty Hosp, Dept Resp Med, Brighton, E Sussex, England. [O'Hehir, Robyn] Alfred Hosp, Dept Allergy Immunol & Resp Med, Melbourne, Vic, Australia. [O'Hehir, Robyn] Monash Univ, Melbourne, Vic, Australia. [Kleine-Tebbe, Joerg] Allergy & Asthma Ctr Westend, Berlin, Germany. [Muraro, Antonella] Padua Gen Univ Hosp, Dept Mother & Child Hlth, Padua, Italy. [Lack, Gideon] MRC, Div Asthma Allergy & Lung Biol, London W1N 4AL, England. [Lack, Gideon] Kings Coll London, Asthma UK Ctr Allerg Mech Asthma, London WC2R 2LS, England. [Lack, Gideon] Guys & St Thomas NHS Fdn Trust, Childrens Allergy Unit, London, England. [Larenas, Desiree] Hosp Med Sur, Mexico City, DF, Mexico. [Levin, Michael] Red Cross War Mem Childrens Hosp, Sch Child & Adolescent Hlth, Div Allergy, Cape Town, South Africa. [Martin, Bryan L.] Walter Reed Army Med Ctr, Dept Allergy & Immunol, Silver Spring, MD USA. [Nelson, Harald] Natl Jewish Hlth, Denver, CO USA. [Pawankar, Ruby] Nippon Med Sch, Dept Pediat, 1-1-5 Sendagi, Tokyo 113, Japan. [Pfaar, Oliver] Univ Hosp Mannheim, Ctr Rhinol & Allergol, Dept Otorhinolaryngol Head & Neck Surg, Mannheim, Germany. [van Ree, Ronald] Univ Amsterdam, Acad Med Ctr, Dept Expt Immunol, NL-1012 WX Amsterdam, Netherlands. [van Ree, Ronald] Univ Amsterdam, Acad Med Ctr, Dept Otorhinolaryngol, NL-1012 WX Amsterdam, Netherlands. [Sampson, Hugh] Icahn Sch Med Mt Sinai, Dept Pediat, Div Allergy Immunol, New York, NY 10029 USA. [Sampson, Hugh] Icahn Sch Med Mt Sinai, Jaffe Food Allergy Inst, New York, NY 10029 USA. [Sublett, James L.] Univ Louisville, Sch Med, Sect Allergy & Immunol, Dept Pediat, Louisville, KY 40292 USA. [Sugita, Kazunari; Akdis, Muebeccel; Akdis, Cezmi A.] Univ Zurich, Swiss Inst Allergy & Asthma Res, CH-8006 Zurich, Switzerland. [Sugita, Kazunari; Akdis, Muebeccel; Akdis, Cezmi A.] Christine Kuhne Ctr Allergy Res & Educ, Davos, Switzerland. [Du Toit, George] Kings Coll London, Div Asthma Allergy & Lung Biol, Dept Pediat Allergy, London WC2R 2LS, England. [Du Toit, George] MRC, London W1N 4AL, England. [Du Toit, George] Asthma UK Ctr Allerg Mech Asthma, London, England. [Werfel, Thomas] Hannover Med Sch, Div Immunodermatol & Allergy Res, Dept Dermatol & Allergy, Hannover, Germany. [van Wijk, Roy Gerth] Erasmus MC, Rotterdam, Netherlands. [Zhang, Luo] Beijing Inst Otolaryngol, Beijing, Peoples R China. RP Jutel, M (reprint author), Wroclaw Med Univ, Dept Clin Immunol, Chalubinskiego 5, PL-50368 Wroclaw, Poland. EM marek.jutel@umed.wroc.pl RI O'Hehir, Robyn/H-3627-2011; OI O'Hehir, Robyn/0000-0002-3489-7595; SUBLETT, JAMES L/0000-0003-4696-4609 FU Anergis; Allergopharma; GLG Research (Gerson Lehrman Group); ActoGeniX; Genentech; Sanofi US Services; Valeant Pharmaceuticals North America; ALK-Abello; Stallergenes; Merck; Greer; Circassia; Stallergenes-Greer; DBV; Thermo Fisher Scientific; Chiesi; Pierre Fabre Medicament; Menarini; MSD; AstraZeneca; NIHR (UK); MEDA; Pfizer; MIT; BI; Novartis Glenmark; Novartis; UCB; GlaxoSmithKline; Astra Zeneca; Senosiain; Sanofi; TEVA; Carnot; Glenmark; Mylan; Pharma Dynamics; INNOVA Pharma; Medical Research Council of South Africa; Thermo Fisher; GlaxoSmithKline/Aspen; Cipla; Astellas; Beiersdorf; Takeda Nycomed; Pearl Therapeutics; Allergopharma (Germany); ALK-Abello (Denmark); Stallergenes (France); HAL-Allergy (Netherlands); Artu Biologicals (Netherlands); Allergy Therapeutics/Bencard (United Kingdom/Germany); Hartington (Spain); Lofarma (Italy); Novartis/Leti (Germany/Spain); GlaxoSmithKline (United Kingdom); Essex-Pharma (Germany); Cytos (Switzerland); Curalogic (Denmark); Roxall (Germany); Biomay (Austria); Thermo Fisher (United States); Circassia (United Kingdom); E.U; Biotech Tools (Belgium); MEDA-Pharma (Sweden); Anergis (Switzerland); Bencard (Germany); Novartis/LETI (Germany); MEDA-Pharma (Germany); GfK Bridgehead (United Kingdom); NAVIGANT-consulting (United States); Sanofi (United States); Guide-point Global Advisors (United States); Pohl-Boskamp (Germany); Mobile Chamber Experts (a GA2LEN partner, Germany); HAL-Allergy (Germany/Netherlands); GlaxoSmithKline (Germany); Thermo-Fisher (Germany); Schattauer (Germany); Springer (Germany); European Academy of Allergy and Clinical Immunology (EAACI); German Society for Allergology and Clinical Immunology (DGAKI); German Respiratory Society (DGP); European Commission; Scientific Advisory Board Chair for HAL Allergy BV; Bayer CropScience; National Institute of Allergy and Infectious Diseases (NIAID) [NO1-AI-15416, UM1AI109565]; Food Allergy and Research Education (FARE); UK Department of Health through NIHR; HAL; Crucell; Emerade; NOW; STW; Biomay; Actelion; Aventis; Circacia; PREDICTA (European Commission's Seventh Framework programme) [260895]; Swiss National Science Foundation; MeDALL (European Commission's Seventh Framework Programme) [261357]; Christine Kuhne-Center FX M. Jutel has received consultancy fees from Anergis and has received lecture fees from Allergopharma. S. Bonini has received travel support and is an expert on secondment at the European Medicine Agency. A. W. Burks is on the FARE and World Allergy Organization boards; is on the Murdoch Children's Research Institute Advisory Board; is an unpaid consultant for Dynavax Technologies, Perrigo Company (PBN Nutritionals), and Perosphere; has received consultancy fees from GLG Research (Gerson Lehrman Group), ActoGeniX, Genentech, Sanofi US Services, and Valeant Pharmaceuticals North America; is employed by the University of North Carolina; has patents US5558869, US55973121, US6441142, US6486311, US6835824, US7485708, and US7879977; has received payment for developing educational presentations from Current Views 2012; has stock/stock options in Allertein and Mastcell Pharmaceuticals; and has received travel support for various grand rounds and presentations. M. Calderon is on the boards for ALK-Abello and HAL Allergy, has received consultancy fees from ALK-Abello and Stallergenes, and has received lecture fees from ALK-Abello, Stallergenes, Merck, and Allergopharma. L. Cox has received personal fees from Greer and is the lead author on one of the studies discussed in the correspondence (publication date 2011) but has had no relationship with the sponsoring company in the past 36 months. P. Demoly has received consultancy fees from ALK-Abello, Circassia, Stallergenes-Greer, Allergopharma, DBV, Thermo Fisher Scientific, Chiesi, and Pierre Fabre Medicament and has received lecture fees from Menarini, MSD, and AstraZeneca. A. J. Frew is on the ALK-Abello board and has received research support from NIHR (UK). D. Larenas is on the CMICA board with no financial gain; has received consultancy fees from MEDA, Pfizer, MIT, BI, Novartis Glenmark, and Chiesi; has received research support from Novartis, Pfizer, MEDA, UCB, GlaxoSmithKline, Astra Zeneca, Senosiain, Sanofi, MSD, TEVA, and Carnot; has received lecture fees from Novartis, Pfizer, MEDA, Astra Zeneca, Sanofi, MSD, TEVA, and Chiesi; has received payment for development of educational presentations from Glenmark; and has received travel support from Novartis, Pfizer, MEDA, AstraZeneca, Sanofi, MSD, and Chiesi. M Levin is on the boards for the Allergy Society of South Africa and the Allergy Foundation of South Africa; has received consultancy fees from Mylan, Pharma Dynamics, and INNOVA Pharma; has received research support from Mylan, the Medical Research Council of South Africa, Thermo Fisher, GlaxoSmithKline/Aspen, AstraZeneca, Cipla, Astellas, Pharma Dynamics, and Beiersdorf; and has received lecture fees from Cipla, Takeda Nycomed, Pharma Dynamics, and Novartis. H. Nelson has received research support from Circassia and has received consulting fees from Circassia, Merck, Pearl Therapeutics and AstraZeneca. O. Pfaar has received research grants for his institution from Allergopharma (Germany), ALK-Abello (Denmark), Stallergenes (France), HAL-Allergy (Netherlands), Artu Biologicals (Netherlands), Allergy Therapeutics/Bencard (United Kingdom/Germany), Hartington (Spain), Lofarma (Italy), Novartis/Leti (Germany/Spain), GlaxoSmithKline (United Kingdom), Essex-Pharma (Germany), Cytos (Switzerland), Curalogic (Denmark), Roxall (Germany), Biomay (Austria), Thermo Fisher (United States), Circassia (United Kingdom), E.; U (FP-7-Health-2013-Innovation 1), Biotech Tools (Belgium), and MEDA-Pharma (Sweden); has received personal payments as consultant for Allergopharma (Germany), Anergis (Switzerland), Bencard (Germany), HAL-Allergy (Netherlands), Novartis/LETI (Germany), MEDA-Pharma (Germany), ALK-Abello (Denmark), Biotech Tools (Belgium), GfK Bridgehead (United Kingdom), NAVIGANT-consulting (United States), Sanofi (United States), Guide-point Global Advisors (United States), Pohl-Boskamp (Germany), Stallergenes (France), and Mobile Chamber Experts (a GA2LEN partner, Germany); has received personal payments for lectures, book chapters, or educational presentations from ALK-Abello (Denmark), Allergopharma (Germany), Stallergenes (France), HAL-Allergy (Germany/Netherlands), Allergy Therapeutics/Bencard (United Kingdom/Germany), Hartington (Spain), Lofarma (Italy), Novartis/Leti (Germany/Spain), GlaxoSmithKline (Germany), Roxall (Germany), Thermo-Fisher (Germany), MEDA-Pharma (Germany), Schattauer (Germany), Springer (Germany). and GlaxoSmithKline (Germany); has served as advisor and on the speakers' bureaus for some of the aforementioned companies; has received travel grants from HAL-Allergy (Netherlands), Allergopharma (Germany), the European Academy of Allergy and Clinical Immunology (EAACI), the German Society for Allergology and Clinical Immunology (DGAKI), and the German Respiratory Society (DGP); and is the current chairman of the Immunotherapy Interest Group (IT IG) of the EAACI and is secretary of the ENT section of the DGAKI. R van Ree has received research support from the European Commission; has received consultancy fees as the Scientific Advisory Board Chair for HAL Allergy BV; is Vice President of the EAACI; has received consultancy fees from Bayer CropScience; and has received lecture fees from Thermo Fisher Scientific. H. Sampson, as of November 1, 2015, is a part-time employee of DBV Technologies and serves as their Chief Scientific Officer; DBV Technologies is developing an epicutaneous patch for the treatment of peanut allergy and other disorders. G. Du Toit has received research support from the National Institute of Allergy and Infectious Diseases (NIAID; NO1-AI-15416 [contract] and UM1AI109565 [grant], covering salary); has received contribution to NIAID contract/grant from Food Allergy and Research Education (FARE); has received Contribution to the KCL Division of Asthma, Allergy & Lung Biology (of which Pediatric Allergy Research is a part) from MRC & Asthma UK Centre; has received a BRC award to Guy's and St Thomas' NHS Foundation from the UK Department of Health through NIHR; and has equity holding in FoodMaestro. R Gerth van Wijk has received consultancy fees from MSD, HAL, Crucell, ALK-Abello, Novartis, and Emerade; has received research support from NOW, STW, Novartis, Biomay, and DBV; has received lecture fees from Allergopharma and Thermo Fisher; has received payment for manuscript preparation from Chiesi; and receives royalties from de Tijdstroom and Bohn, Stafleu, van Loghum. C. A. Akdis has received consultancy fees from Actelion, Aventis, Stallergenes, Allergopharma, and Circacia; is employed by the Swiss Institute of Allergy and Asthma Research, University of Zurich, Switzerland; has received research support from Novartis, PREDICTA (European Commission's Seventh Framework programme no. 260895), the Swiss National Science Foundation, MeDALL (European Commission's Seventh Framework Programme no. 261357), and the Christine Kuhne-Center. The rest of the authors declare that they have no relevant conflicts of interest. NR 91 TC 16 Z9 16 U1 0 U2 13 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0091-6749 EI 1097-6825 J9 J ALLERGY CLIN IMMUN JI J. Allergy Clin. Immunol. PD FEB PY 2016 VL 137 IS 2 BP 358 EP 368 DI 10.1016/j.jaci.2015.12.1300 PG 11 WC Allergy; Immunology SC Allergy; Immunology GA DC5BN UT WOS:000369235500003 PM 26853128 ER PT J AU O'Connor, KL Scisco, JL Smith, TJ Young, AJ Montain, SJ Price, LL Lieberman, HR Karl, JP AF O'Connor, Kristie L. Scisco, Jenna L. Smith, Tracey J. Young, Andrew J. Montain, Scott J. Price, Lori Lyn Lieberman, Harris R. Karl, J. Philip TI Altered Appetite-Mediating Hormone Concentrations Precede Compensatory Overeating After Severe, Short-Term Energy Deprivation in Healthy Adults SO JOURNAL OF NUTRITION LA English DT Article DE calorie restriction; energy density; satiety; weight loss; gut hormone; intermittent fasting; energy balance ID GLUCAGON-LIKE PEPTIDE-1; FOOD-INTAKE; WEIGHT-LOSS; BODY-WEIGHT; OBESE MEN; DIETARY RESTRICTION; INTAKE RESPONSES; GHRELIN LEVELS; CENTRAL LEPTIN; EATING RATE AB Background: Adaptive responses of appetite-mediating hormones to negative energy balance are thought to contribute to a counterregulatory response that drives weight regain, but they have not been studied while controlling for reduced diet volume. Objective: In this secondary analysis, we aimed to determine the effects of short-term, severe energy deprivation (ED) on appetite and appetite-mediating hormone concentrations. Methods: Twenty-one adults with a mean +/- SD age of 21 +/- 3 y and body mass index of 25 +/- 3 kg/m(2) consumed isovolumetric diets provided over separate 48-h periods while increasing habitual energy expenditure by 1683 +/- 329 kcal/d through light- and moderate-intensity exercise. Energy intake was matched to energy expenditure to maintain energy balance (EB) (-44 +/- 92 kcal/d) or was <10% of energy expenditure to generate a 3696 +/- 742-kcal/d energy deficit. Postprandial appetite, glucose, insulin, acyl ghrelin, peptide YY, pancreatic polypeptide (PP), and glucagon-like peptide-1 (GLP-1) responses and ad libitum energy intake were measured as secondary outcomes after both experimental periods. Results: Fasting insulin (-56% +/- 42%) and acyl ghrelin (-60% +/- 17%) concentrations decreased during ED but not during EB (condition-by-time interaction; P-interaction <= 0.01), whereas fasting leptin concentrations decreased more during ED compared with during EB (-47% +/- 27% compared with 20% +/- 27%; P-interaction = 0.05). Postprandial insulin (57% +/- 63%; P < 0.001), GLP-1 (14% +/- 28%; P = 0.04), and PP (54% +/- 52%; P < 0.001) areas under the curve (AUCs) were higher, whereas the acyl ghrelin AUC was lower (-56% +/- 13%; P < 0.001) after ED compared with after EB. After ED, self-rated appetite was greater, and ad libitum energy intake was 811 kcal/36 h (95% CI: 184, 1439 kcal/36 h) higher relative to after EB (P = 0.01). Conclusions: Short-term, severe ED suppressed acyl ghrelin concentrations and increased postprandial anorexigenic hormone concentrations. These effects preceded compensatory overeating, suggesting that in adults without obesity, altered sensitivity to appetite-mediating hormones may contribute to an adaptive counterregulatory response during the initial stages of negative EB. This trial was registered at clinicaltrials.gov as NCT01603550. C1 [O'Connor, Kristie L.; Scisco, Jenna L.; Smith, Tracey J.; Young, Andrew J.; Montain, Scott J.; Lieberman, Harris R.; Karl, J. Philip] US Army, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. [Price, Lori Lyn] Tufts Univ, Tufts Med Ctr, Inst Clin Res & Hlth Policy Studies, Boston, MA 02111 USA. [Price, Lori Lyn] Tufts Univ, Tufts Clin & Translat Sci Inst, Boston, MA 02111 USA. RP Karl, JP (reprint author), US Army, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. EM james.p.karl.civ@mail.mil FU US Army Medical Research and Materiel Command FX Supported by the US Army Medical Research and Materiel Command. NR 56 TC 2 Z9 2 U1 5 U2 16 PU AMER SOC NUTRITION-ASN PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-3166 EI 1541-6100 J9 J NUTR JI J. Nutr. PD FEB PY 2016 VL 146 IS 2 BP 209 EP 217 DI 10.3945/jn.115.217976 PG 9 WC Nutrition & Dietetics SC Nutrition & Dietetics GA DC9RD UT WOS:000369557800005 PM 26740683 ER PT J AU Penn, AH Carver, LJ Herbert, CA Lai, TS McIntire, MJ Howard, JT Taylor, SF Schmid-Schonbein, GW Dobkins, KR AF Penn, Alexander H. Carver, Leslie J. Herbert, Carrie A. Lai, Tiffany S. McIntire, Melissa J. Howard, Jeffrey T. Taylor, Sharon F. Schmid-Schoenbein, Geert W. Dobkins, Karen R. TI Breast Milk Protects Against Gastrointestinal Symptoms in Infants at High Risk for Autism During Early Development SO JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION LA English DT Article DE abdominal discomfort/pain; breast milk; breast-feeding; constipation; pervasive developmental disorder ID SPECTRUM DISORDERS; INTESTINAL PERMEABILITY; NECROTIZING ENTEROCOLITIS; MUCOSAL INJURY; FATTY-ACIDS; OLEIC-ACID; CHILDREN; MUCUS; INDIVIDUALS; POPULATION AB Objectives: Parents of children with autism spectrum disorders (ASDs) often report gastrointestinal (GI) dysfunction in their children. The objectives of the present study were to determine whether infants at high risk for developing ASD (ie, siblings of children diagnosed as having ASD) show greater prevalence of GI problems and whether this prevalence is associated with diet and age at weaning from breast milk. Methods:Using questionnaires, diet history and GI problems were tracked prospectively and retrospectively in 57 high-risk infants and for comparison in 114 low-risk infants (infants from families without ASD history). Results: In low-risk infants, prevalence of GI symptoms, in aggregate, did not vary with diet or age of weaning. By contrast, high-risk infants with GI symptoms were weaned earlier than those without symptoms (P<0.04), and high-risk infants showed greater prevalence of GI symptoms, in aggregate, on a no breast milk diet than on an exclusive breast milk diet (P<0.017). Constipation, in particular, was more prevalent in high-risk infants compared with low-risk infants (P=0.01), especially on a no breast milk diet (P=0.002). High-risk infants who completed weaning earlier than 6 months showed greater prevalence of constipation (P=0.001) and abdominal distress (P=0.004) than those fully weaned after 6 months. Conclusions:The greater prevalence of GI symptoms in high-risk infants suggests that GI dysfunction during early infant development may be a part of the ASD endophenotype. Late weaning and exclusive breast milk were associated with protection against GI symptoms in high-risk infants. C1 [Schmid-Schoenbein, Geert W.] Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA. [Carver, Leslie J.; Herbert, Carrie A.; Lai, Tiffany S.; McIntire, Melissa J.; Dobkins, Karen R.] Univ Calif San Diego, Dept Psychol, La Jolla, CA 92093 USA. [Taylor, Sharon F.] Univ Calif San Diego, Dept Pediat, La Jolla, CA 92093 USA. [Carver, Leslie J.] Univ Calif San Diego, Dept Human Dev Program, La Jolla, CA 92093 USA. [Dobkins, Karen R.] Rady Childrens Hosp, San Diego, CA USA. [Penn, Alexander H.; Howard, Jeffrey T.] US Army, Inst Surg Res, San Antonio, TX USA. RP Dobkins, KR (reprint author), Univ Calif San Diego, Dept Psychol, La Jolla, CA 92093 USA.; Penn, AH (reprint author), US Army, Inst Surg Res, San Antonio, TX USA. EM alexander.h.penn.vol@mail.mil; kdobkins@ucsd.edu FU National Institutes of Health [NS071580] FX This study was supported by the National Institutes of Health grant number NS071580. NR 48 TC 1 Z9 1 U1 6 U2 13 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0277-2116 EI 1536-4801 J9 J PEDIATR GASTR NUTR JI J. Pediatr. Gastroenterol. Nutr. PD FEB PY 2016 VL 62 IS 2 BP 317 EP 327 DI 10.1097/MPG.0000000000000907 PG 11 WC Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics SC Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics GA DC5WV UT WOS:000369292300010 PM 26230900 ER PT J AU Carter, JR Baker, DR Witt, TA Bruce, BD AF Carter, J. Ridge Baker, David R. Witt, T. Austin Bruce, Barry D. TI Enhanced photocurrent from Photosystem I upon in vitro truncation of the antennae chlorophyll SO PHOTOSYNTHESIS RESEARCH LA English DT Article DE Photosystem I; Hydroxyapatite; Photocurrent; Chlorophyll; Light-harvesting complex I, II ID CHLAMYDOMONAS-REINHARDTII; PROTEIN; COMPLEX; ENERGY; PHOTOSYNTHESIS; HYDROXYAPATITE; EVOLUTION; ELECTRODE; SUBUNIT; CELLS AB Current effects on climate change and dwindling fossil fuel reserves require new materials and methods to convert solar energy into a viable clean energy source. Recent progress in the direct conversion of light into photocurrent has been well documented using Photosystem I. In plants, PSI consists of a core complex and multiple light-harvesting complexes, denoted LHCI and LHCII. Most of the methods for isolating PSI from plants involve a selective, detergent solubilization from thylakoids followed by sucrose gradient density centrifugation. These processes isolate one variant of PSI with a specific ratio of Chl:P-700. In this study, we have developed a simple and potentially scalable method for isolating multiple PSI variants using Hydroxyapatite chromatography, which has been well documented in other Photosystem I isolation protocols. By varying the wash conditions, we show that it is possible to change the Chl:P-700 ratios. These different PSI complexes were cast into a PSI-Nafion-osmium polymer film that enabled their photoactivity to be measured. Photocurrent increases nearly 400 % between highly washed and untreated solutions based on equal chlorophyll content. Importantly, the mild washing conditions remove peripheral Chl and some LHCI without inhibiting the photochemical activity of PSI as suggested by SDS-PAGE analysis. This result could indicate that more P-700 could be loaded per surface area for biohybrid devices. Compared with other PSI isolations, this protocol also allows isolation of multiple PSI variants without loss of photochemical activity. C1 [Carter, J. Ridge; Witt, T. Austin; Bruce, Barry D.] Univ Tennessee, Dept Biochem & Cellular & Mol Biol, Knoxville, TN 37996 USA. [Baker, David R.] US Army, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. [Bruce, Barry D.] Univ Tennessee, Program Energy Sci & Engn, Knoxville, TN 37996 USA. RP Bruce, BD (reprint author), Univ Tennessee, Dept Biochem & Cellular & Mol Biol, Knoxville, TN 37996 USA.; Bruce, BD (reprint author), Univ Tennessee, Program Energy Sci & Engn, Knoxville, TN 37996 USA. EM bbruce@utk.edu FU Army Research Laboratories (ARL) [W91 1NF-11-2-0029]; NSF-EPSCoR [EPS-1004083]; Gibson Family Foundation FX We would like to thank the Army Research Laboratories (ARL Contract #W91 1NF-11-2-0029), TN-SCORE sponsored by NSF-EPSCoR (EPS-1004083), and the Gibson Family Foundation for the generous funding for this project. We also appreciate the support and feedback provided by Khoa Nguyen, Prakitchai Chotewutmontri, and Richard Simmerman, and Ed Wright while conducting this research. NR 36 TC 0 Z9 0 U1 5 U2 19 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0166-8595 EI 1573-5079 J9 PHOTOSYNTH RES JI Photosynth. Res. PD FEB PY 2016 VL 127 IS 2 BP 161 EP 170 DI 10.1007/s11120-015-0162-5 PG 10 WC Plant Sciences SC Plant Sciences GA DC7UD UT WOS:000369425000002 PM 26031418 ER PT J AU Omelchenko, IV Shishkin, OV Gorb, L Leszczynski, J AF Omelchenko, Irina V. Shishkin, Oleg V. Gorb, Leonid Leszczynski, Jerzy TI Aromaticity and conformational flexibility of five-membered monoheterocycles: pyrrole-like and thiophene-like structures SO STRUCTURAL CHEMISTRY LA English DT Article DE Aromaticity; Five-membered heterocycles; Aromaticity indices; Aromatic ring flexibility ID PI-ELECTRON DELOCALIZATION; PHOSPHORUS-HETEROCYCLES; TRICOORDINATE PHOSPHORUS; 6-MEMBERED HETEROCYCLES; QUANTITATIVE CONCEPT; RING-SYSTEMS; PLANAR; ANALOGS; HETEROAROMATICITY; SUBSTITUENTS AB Aromaticity and conformational flexibility of the series of five-membered monoheterocycles with group 14-16 heteroatoms, having one or two lone pairs, were studied with ab initio methods using NICS, ASE and I (5) indices. For non-planar molecules like phosphole, aromaticity of their planar transition states was also studied, and a special modification of ASE index was proposed to that end. It was found that the presence of two lone pairs is generally preferable for aromaticity of all heterocycles except CPD and silolyl dianions. Heterocycles with group 16 heteroatoms have consistently lower aromaticity compared to other groups. A lot of structures should be classified as moderate aromatic and non-aromatic. Energies of out-of-plane deformation do not correlate with other indices studied, but reveal the same qualitative trends. Generally, aromaticity of five-membered monoheterocycles depends strongly on both heteroatom type and number of lone pairs on it. C1 [Omelchenko, Irina V.; Shishkin, Oleg V.] Natl Acad Sci Ukraine, SSI Inst Single Crystals, 60 Lenin Ave, UA-61001 Kharkov, Ukraine. [Shishkin, Oleg V.] Kharkov Natl Univ, 4 Svobody Sq, UA-61077 Kharkov, Ukraine. [Gorb, Leonid] Badger Tech Serv LLC, Vicksburg, MS USA. [Leszczynski, Jerzy] US Army, Erdc, 3532 Manor Dr, Vicksburg, MS 39180 USA. [Leszczynski, Jerzy] Jackson State Univ, Dept Chem & Biochem, Interdisciplinary Ctr Nanotox, POB 17910,1325 Lynch St, Jackson, MS 39217 USA. RP Omelchenko, IV (reprint author), Natl Acad Sci Ukraine, SSI Inst Single Crystals, 60 Lenin Ave, UA-61001 Kharkov, Ukraine. EM irina@xray.isc.kharkov.com OI Omelchenko, Iryna/0000-0002-6882-6832 NR 52 TC 1 Z9 1 U1 2 U2 10 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1040-0400 EI 1572-9001 J9 STRUCT CHEM JI Struct. Chem. PD FEB PY 2016 VL 27 IS 1 SI SI BP 101 EP 109 DI 10.1007/s11224-015-0707-4 PG 9 WC Chemistry, Multidisciplinary; Chemistry, Physical; Crystallography SC Chemistry; Crystallography GA DC5KT UT WOS:000369260600013 ER PT J AU Tinkov, OV Ognichenko, LN Kuz'min, VE Gorb, LG Kosinskaya, AP Muratov, NN Muratov, EN Hill, FC Leszczynski, J AF Tinkov, Oleg V. Ognichenko, Luidmila N. Kuz'min, Victor E. Gorb, Leonid G. Kosinskaya, Anna P. Muratov, Nail N. Muratov, Eugene N. Hill, Frances C. Leszczynski, Jerzy TI Computational assessment of environmental hazards of nitroaromatic compounds: influence of the type and position of aromatic ring substituents on toxicity SO STRUCTURAL CHEMISTRY LA English DT Article DE Nitroaromatic xenobiotics; Acute toxicity; SiRMS; Virtual screening ID HIERARCHICAL QSAR TECHNOLOGY; SIMPLEX REPRESENTATION; TETRAHYMENA-PYRIFORMIS; MOLECULAR-STRUCTURE; PREDICTION AB This study summarizes the results of our recent QSAR and QSPR investigations on prediction of numerous aspects of environmental behavior of nitro compounds. In this study, we applied the QSAR/QSPR models previously developed by our group for virtual screening of energetic compounds, their precursors and other compounds containing nitro groups. To make predictions on the environmental impact of nitro compounds, we analyzed the trends in the change of the experimentally obtained and QSAR/QSPR-predicted values of aqueous solubility, lipophilicity, Ames mutagenicity, bioavailability, blood-brain barrier penetration, aquatic toxicity on T. pyriformis and acute oral toxicity on rats as a function of chemical structure of nitro compounds. All the models were developed using simplex descriptors in combination with random forest (RF) modeling techniques. We interpreted the possible environmental impact (different toxicological properties) in terms of dividing considered nitro compounds based on hydrophobic and hydrophilic characteristics and in terms of the influence of their molecular fragments that promote and interfere with toxicity. In particular, we found that, in general, the presence of amide or tertiary amine groups leads to an increase in toxicity. Also, it was predicted that compounds containing a NO2 group in the para-position of a benzene ring are more toxic than meta-isomers, which, in turn, are more toxic than ortho-isomers. In general, we concluded that hydrophobic nitroaromatic compounds, especially the ones with electron-accepting substituents, halogens and amino groups, are the most environmentally hazardous. C1 [Tinkov, Oleg V.] TG Shevchenko State Univ, Dept Chem, Tiraspol 3300, Moldova. [Ognichenko, Luidmila N.; Kuz'min, Victor E.; Kosinskaya, Anna P.] AV Bogatsky Phys Chem Inst NAS Ukraine, Dept Mol Struct & Chemoinformat, UA-65080 Odessa, Ukraine. [Gorb, Leonid G.] HX5 LLC, Vicksburg, MS 39180 USA. [Kosinskaya, Anna P.] Odessa Natl Med Univ, 2 Valikhovskiy Lane, UA-65026 Odessa, Ukraine. [Muratov, Nail N.] Odessa Natl Polytech Univ, Dept Chem Technol, UA-65000 Odessa, Ukraine. [Muratov, Eugene N.] Univ N Carolina, Eshelman Sch Pharm, Div Chem Biol & Med Chem, Lab Mol Modeling, Chapel Hill, NC 27599 USA. [Hill, Frances C.] US Army, Ctr Res & Dev, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. [Leszczynski, Jerzy] Jackson State Univ, Interdisciplinary Nanotox Ctr, Dept Civil & Environm Engn, Jackson, MS 39217 USA. RP Leszczynski, J (reprint author), Jackson State Univ, Interdisciplinary Nanotox Ctr, Dept Civil & Environm Engn, Jackson, MS 39217 USA. EM jerzy@icnanotox.org RI Muratov, Eugene/C-4454-2014 OI Muratov, Eugene/0000-0003-4616-7036 FU ERDC [W912HZ-13-P-0037]; National Science Foundation [OCI-1053575]; XSEDE award [DMR110088]; US National Institutes of Health [GM 096967, GM66940]; Environmental Quality Technology Program of the United States Army Corps of Engineers by US Army ERDC FX We thank ERDC for financial support (grant number W912HZ-13-P-0037). The computation time was provided by the Extreme Science and Engineering Discovery Environment (XSEDE) by National Science Foundation Grant Number OCI-1053575 and XSEDE award allocation Number DMR110088 and by the Mississippi Center for Supercomputer Research. EM is grateful for financial support from the US National Institutes of Health (GM 096967 and GM66940). The use of trade, product or firm names in this report is for descriptive purposes only and does not imply endorsement by the US Government. Results in this study were funded and obtained from research conducted under the Environmental Quality Technology Program of the United States Army Corps of Engineers by the US Army ERDC. Permission was granted by the Chief of Engineers to publish this information. The findings of this report are not to be construed as an official Department of the Army position unless so designated by other authorized documents. NR 26 TC 1 Z9 1 U1 1 U2 7 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1040-0400 EI 1572-9001 J9 STRUCT CHEM JI Struct. Chem. PD FEB PY 2016 VL 27 IS 1 SI SI BP 191 EP 198 DI 10.1007/s11224-015-0715-4 PG 8 WC Chemistry, Multidisciplinary; Chemistry, Physical; Crystallography SC Chemistry; Crystallography GA DC5KT UT WOS:000369260600021 ER PT J AU Sipulwa, LA Ongus, JR Coldren, RL Bulimo, WD AF Sipulwa, Lenata A. Ongus, Juliette R. Coldren, Rodney L. Bulimo, Wallace D. TI Molecular characterization of human coronaviruses and their circulation dynamics in Kenya, 2009-2012 SO VIROLOGY JOURNAL LA English DT Article DE Molecular characterization; Human coronaviruses; Prevalence; Kenya; HCOV NL63; HCoV OC43; HCoV 229E; HCoV-HKU1 ID RESPIRATORY-TRACT INFECTION; POLYMERASE-CHAIN-REACTION; FREQUENT DETECTION; HONG-KONG; CHILDREN; NL63; PNEUMONIA; SEQUENCE; DISEASE; VIRUS AB Background: Human Coronaviruses (HCoV) are a common cause of respiratory illnesses and are responsible for considerable morbidity and hospitalization across all age groups especially in individuals with compromised immunity. There are six known species of HCoV: HCoV-229E, HCoV-NL63, HCoV-HKU1, HCoV-OC43, MERS-CoV and SARS-HCoV. Although studies have shown evidence of global distribution of HCoVs, there is limited information on their presence and distribution in Kenya. Methods: HCoV strains that circulated in Kenya were retrospectively diagnosed and molecularly characterized. A total of 417 nasopharyngeal specimens obtained between January 2009 and December 2012 from around Kenya were analyzed by a real time RT-PCR using HCoV-specific primers. HCoV-positive specimens were subsequently inoculated onto monolayers of LL-CMK2 cells. The isolated viruses were characterized by RT-PCR amplification and sequencing of the partial polymerase (pol) gene. Results: The prevalence of HCoV infection was as follows: out of the 417 specimens, 35 (8.4 %) were positive for HCoV, comprising 10 (2.4 %) HCoV-NL63, 12 (2.9 %) HCoV-OC43, 9 (2.1 %) HCoV-HKU1, and 4 (1 %) HCoV-229E. The Kenyan HCoV strains displayed high sequence homology to the prototypes and contemporaneous strains. Evolution analysis showed that the Kenyan HCoV-OC43 and HCoV-NL63 isolates were under purifying selection. Phylogenetic evolutionary analyses confirmed the identities of three HCoV-HKU1, five HCoV-NL63, eight HCoV-OC43 and three HCoV-229E. Conclusions: There were yearly variations in the prevalence and circulation patterns of individual HCoVs in Kenya. This paper reports on the first molecular characterization of human Coronaviruses in Kenya, which play an important role in causing acute respiratory infections among children. C1 [Sipulwa, Lenata A.; Ongus, Juliette R.] Jomo Kenyatta Univ Agr & Technol, Coll Hlth Sci COHES, Nairobi, Kenya. [Coldren, Rodney L.; Bulimo, Wallace D.] US Army Med Res Unit Kenya, Dept Emerging Infect Dis, POB 606, Nairobi 00621, Kenya. [Coldren, Rodney L.; Bulimo, Wallace D.] Walter Reed Army Inst Res, Special Foreign Act, Silver Spring, MD USA. [Bulimo, Wallace D.] Univ Nairobi, Sch Med, Dept Biochem, Nairobi, Kenya. RP Bulimo, WD (reprint author), US Army Med Res Unit Kenya, Dept Emerging Infect Dis, POB 606, Nairobi 00621, Kenya.; Bulimo, WD (reprint author), Walter Reed Army Inst Res, Special Foreign Act, Silver Spring, MD USA.; Bulimo, WD (reprint author), Univ Nairobi, Sch Med, Dept Biochem, Nairobi, Kenya. EM Wallace.bulimo@uonbi.ac.ke RI Bulimo, Wallace/B-1982-2014 OI Bulimo, Wallace/0000-0001-8475-0586 FU US Armed Forces Health Surveillance Center Division of GEIS Operations FX We thank the patients who provided specimens for this work. We also thank the following individuals: Ms Rachel Achilla, Mr. Benjamin Opot and Silvanos Mukunzi of the US Army Medical Research Unit-Kenya, for laboratory management, nucleotide sequencing and analysis respectively. Funding was provided by the US Armed Forces Health Surveillance Center Division of GEIS Operations. The control RNA for HCoV-NL63 was provided by Prof. James Nokes of KWTRP-Kilifi. NR 32 TC 0 Z9 0 U1 1 U2 3 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1743-422X J9 VIROL J JI Virol. J. PD FEB 1 PY 2016 VL 13 AR 18 DI 10.1186/s12985-016-0474-x PG 9 WC Virology SC Virology GA DC6WH UT WOS:000369359800001 PM 26833249 ER PT J AU Touryan, J Kerick, SE Ries, AJ McDowell, K AF Touryan, Jon Kerick, Scott E. Ries, Anthony J. McDowell, Kaleb TI Common EEG features for behavioral estimation in disparate, real-world tasks SO BIOLOGICAL PSYCHOLOGY LA English DT Article DE EEG; Feature selection; Performance estimation; Fatigue; Learning; Real world tasks ID INDEPENDENT COMPONENT ANALYSIS; BRAIN-COMPUTER INTERFACE; DRIVER FATIGUE; BLIND SEPARATION; DROWSINESS; PERFORMANCE; PREDICTION; ALERTNESS; SPECTRUM; SYSTEM AB In this study we explored the potential for capturing the behavioral dynamics observed in real-world tasks from concurrent measures of EEG. In doing so, we sought to develop models of behavior that would enable the identification of common cross-participant and cross-task EEG features. To accomplish this we had participants perform both simulated driving and guard duty tasks while we recorded their EEG. For each participant we developed models to estimate their behavioral performance during both tasks. Sequential forward floating selection was used to identify the montage of independent components for each model. Linear regression was then used on the combined power spectra from these independent components to generate a continuous estimate of behavior. Our results show that oscillatory processes, evidenced in EEG, can be used to successfully capture slow fluctuations in behavior in complex, multi-faceted tasks. The average correlation coefficients between the actual and estimated behavior was 0.548 +/- 0.117 and 0.701 +/- 0.154 for the driving and guard duty tasks respectively. Interestingly, through a simple clustering approach we were able to identify a number of common components, both neural and eye-movement related, across participants and tasks. We used these component clusters to quantify the relative influence of common versus participant-specific features in the models of behavior. These findings illustrate the potential for estimating complex behavioral dynamics from concurrent measures from EEG using a finite library of universal features. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license C1 [Touryan, Jon; Kerick, Scott E.; Ries, Anthony J.; McDowell, Kaleb] US Army Res Lab, Human Res & Engn Directorate, 459 Mulberry Point Rd, Aberdeen Proving Ground, MD 21005 USA. RP Touryan, J (reprint author), US Army Res Lab, Human Res & Engn Directorate, 459 Mulberry Point Rd, Aberdeen Proving Ground, MD 21005 USA. EM jonathan.o.touryan.civ@mail.mil FU U.S. Army Research Laboratory FX Research was sponsored by the U.S. Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-12-2-0019. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 53 TC 0 Z9 0 U1 2 U2 13 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0301-0511 EI 1873-6246 J9 BIOL PSYCHOL JI Biol. Psychol. PD FEB PY 2016 VL 114 BP 93 EP 107 DI 10.1016/j.biopsycho.2015.12.009 PG 15 WC Psychology, Biological; Behavioral Sciences; Psychology; Psychology, Experimental SC Psychology; Behavioral Sciences GA DC0WF UT WOS:000368937900010 PM 26748290 ER PT J AU Gutteridge, CE Major, JW Nin, DA Curtis, SM Bhattacharjee, AK Gerena, L Nichols, DA AF Gutteridge, Clare E. Major, Joshua W. Nin, Daniel A. Curtis, Sean M. Bhattacharjee, Apurba K. Gerena, Lucia Nichols, Daniel A. TI In vitro efficacy of 2,N-bisarylated 2-ethoxyacetamides against Plasmodium falciparum SO BIOORGANIC & MEDICINAL CHEMISTRY LETTERS LA English DT Article DE Chalcone; 2-Ethoxyacetamide; Malaria; Plasmodium falciparum; 1,3-Diphenyl-2-propen-1-ones ID VIVO EFFICACY; CHALCONES; LICOCHALCONE; DERIVATIVES; METABOLISM; AGENT; ACIDS AB Investigation of a series of 2, N-bisarylated 2-ethoxyacetamides resulted in the identification of four inhibitors 5, 20, 24, 29 with single-digit micromolar in vitro efficacy against two drug-resistant Plasmodium falciparum strains. These compounds are analogs of structurally-related 1,3-bisaryl-2-propen-1-ones (chalcones), the latter showing efficacy in vitro but not in a malaria-infected mouse. The 2, N-bisarylated 2-ethoxyacetamides (e.g., 2, 5, 20) were shown to possess significantly greater stability in the presence of metabolizing enzymes than the corresponding 1,3-bisaryl-2-propen-1-ones (e.g., 1, 3, 18). Published by Elsevier Ltd. C1 [Gutteridge, Clare E.; Major, Joshua W.; Nin, Daniel A.; Curtis, Sean M.] US Naval Acad, Dept Chem, Annapolis, MD 21402 USA. [Bhattacharjee, Apurba K.; Gerena, Lucia; Nichols, Daniel A.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. RP Gutteridge, CE (reprint author), US Naval Acad, Dept Chem, Annapolis, MD 21402 USA. EM gutterid@usna.edu FU Cottrell College Science Award from The Research Corporation for Science Advancement; Military Infectious Diseases Research Program; Office of Naval Research; Naval Academy Research Council of the United States Naval Academy FX We are grateful for support of this work by a Cottrell College Science Award from The Research Corporation for Science Advancement, by the Military Infectious Diseases Research Program, by the Office of Naval Research, and by the Naval Academy Research Council of the United States Naval Academy. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official, or reflecting true views of the Department of Defense, the Department of the Army or the Department of the Navy. NR 23 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0960-894X EI 1464-3405 J9 BIOORG MED CHEM LETT JI Bioorg. Med. Chem. Lett. PD FEB 1 PY 2016 VL 26 IS 3 BP 1048 EP 1051 DI 10.1016/j.bmcl.2015.12.032 PG 4 WC Chemistry, Medicinal; Chemistry, Organic SC Pharmacology & Pharmacy; Chemistry GA DB8WJ UT WOS:000368797600070 PM 26750257 ER PT J AU Bolton, DL Pegu, A Wang, KY McGinnis, K Nason, M Foulds, K Letukas, V Schmidt, SD Chen, XJ Todd, JP Lifson, JD Rao, S Michael, NL Robb, ML Mascola, JR Koup, RA AF Bolton, Diane L. Pegu, Amarendra Wang, Keyun McGinnis, Kathleen Nason, Martha Foulds, Kathryn Letukas, Valerie Schmidt, Stephen D. Chen, Xuejun Todd, John Paul Lifson, Jeffrey D. Rao, Srinivas Michael, Nelson L. Robb, Merlin L. Mascola, John R. Koup, Richard A. TI Human Immunodeficiency Virus Type 1 Monoclonal Antibodies Suppress Acute Simian-Human Immunodeficiency Virus Viremia and Limit Seeding of Cell-Associated Viral Reservoirs SO JOURNAL OF VIROLOGY LA English DT Article ID BROADLY NEUTRALIZING ANTIBODIES; PASSIVE TRANSFER; IN-VIVO; PHASE-I; NONHUMAN-PRIMATES; ANTIVIRAL THERAPY; CD4-BINDING SITE; RHESUS-MONKEYS; HIV RESERVOIR; T(H)1 CELLS AB Combination antiretroviral therapy (cART) administered shortly after human immunodeficiency virus type 1 (HIV-1) infection can suppress viremia and limit seeding of the viral reservoir, but lifelong treatment is required for the majority of patients. Highly potent broadly neutralizing HIV-1 monoclonal antibodies (MAbs) can reduce plasma viremia when administered during chronic HIV-1 infection, but the therapeutic potential of these antibodies during acute infection is unknown. We tested the ability of HIV-1 envelope glycoprotein-specific broadly neutralizing MAbs to suppress acute simian-human immunodeficiency virus (SHIV) replication in rhesus macaques. Four groups of macaques were infected with SHIV-SF162P3 and received (i) the CD4-binding-site MAb VRC01; (ii) a combination of a more potent clonal relative of VRC01 (VRC07-523) and a V3 glycan-dependent MAb (PGT121); (iii) daily cART, all on day 10, just prior to expected peak plasma viremia; or (iv) no treatment. Daily cART was initiated 11 days after MAb administration and was continued for 13 weeks in all treated animals. Over a period of 11 days after a single administration, MAb treatment significantly reduced peak viremia, accelerated the decay slope, and reduced total viral replication compared to untreated controls. Proviral DNA in lymph node CD4 T cells was also diminished after treatment with the dual MAb. These data demonstrate the virological effect of potent MAbs and support future clinical trials that investigate HIV-1-neutralizing MAbs as adjunctive therapy with cART during acute HIV-1 infection. C1 [Bolton, Diane L.; Michael, Nelson L.; Robb, Merlin L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Bolton, Diane L.; Robb, Merlin L.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Pegu, Amarendra; Wang, Keyun; McGinnis, Kathleen; Foulds, Kathryn; Letukas, Valerie; Schmidt, Stephen D.; Chen, Xuejun; Todd, John Paul; Rao, Srinivas; Mascola, John R.; Koup, Richard A.] NIAID, Vaccine Res Ctr, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA. [Nason, Martha] NIAID, Biostat Res Branch, Div Clin Res, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA. [Lifson, Jeffrey D.] Leidos Biomed Res Inc, AIDS & Canc Virus Program, Frederick Natl Lab Canc Res, AIDS & Canc Virus Program, Frederick, MD USA. [Rao, Srinivas] 640 Mem Dr, Cambridge, MA USA. RP Bolton, DL (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. EM dbolton@hivresearch.org RI Schmidt, Stephen/B-5398-2012 FU Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; U.S. Department of Defense (DOD) [W81XWH-07-2-0067]; U.S. National Institute of Allergy and Infectious Diseases; National Cancer Institute [HHSN261200800001E] FX This work was supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense (DOD). This research was funded in part by the U.S. National Institute of Allergy and Infectious Diseases and in part with federal funds under contract no. HHSN261200800001E from the National Cancer Institute. The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication. NR 48 TC 9 Z9 9 U1 1 U2 7 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X EI 1098-5514 J9 J VIROL JI J. Virol. PD FEB PY 2016 VL 90 IS 3 BP 1321 EP 1332 DI 10.1128/JVI.02454-15 PG 12 WC Virology SC Virology GA DC3WW UT WOS:000369150800014 PM 26581981 ER PT J AU Riblett, AM Blomen, VA Jae, LT Altamura, LA Doms, RW Brummelkamp, TR Wojcechowskyj, JA AF Riblett, Amber M. Blomen, Vincent A. Jae, Lucas T. Altamura, Louis A. Doms, Robert W. Brummelkamp, Thijn R. Wojcechowskyj, Jason A. TI A Haploid Genetic Screen Identifies Heparan Sulfate Proteoglycans Supporting Rift Valley Fever Virus Infection SO JOURNAL OF VIROLOGY LA English DT Article ID HERPES-SIMPLEX-VIRUS; HUMAN XYLOSYLTRANSFERASE-II; PROTEIN LINKAGE REGION; MOLECULAR-CLONING; ADENOASSOCIATED VIRUS; ENTRY REQUIRES; SAUDI-ARABIA; CELL-FUSION; DC-SIGN; BIOSYNTHESIS AB Rift Valley fever virus (RVFV) causes recurrent insect-borne epizootics throughout the African continent, and infection of humans can lead to a lethal hemorrhagic fever syndrome. Deep mutagenesis of haploid human cells was used to identify host factors required for RVFV infection. This screen identified a suite of enzymes involved in glycosaminoglycan (GAG) biogenesis and transport, including several components of the cis-oligomeric Golgi (COG) complex, one of the central components of Golgi complex trafficking. In addition, disruption of PTAR1 led to RVFV resistance as well as reduced heparan sulfate surface levels, consistent with recent observations that PTAR1-deficient cells exhibit altered Golgi complex morphology and glycosylation defects. A variety of biochemical and genetic approaches were utilized to show that both pathogenic and attenuated RVFV strains require GAGs for efficient infection on some, but not all, cell types, with the block to infection being at the level of virion attachment. Examination of other members of the Bunyaviridae family for GAG-dependent infection suggested that the interaction with GAGs is not universal among bunyaviruses, indicating that these viruses, as well as RVFV on certain cell types, employ additional unidentified virion attachment factors and/or receptors. C1 [Riblett, Amber M.; Wojcechowskyj, Jason A.] Univ Penn, Dept Microbiol, Perelman Sch Med, Philadelphia, PA 19104 USA. [Blomen, Vincent A.; Jae, Lucas T.; Brummelkamp, Thijn R.] Netherlands Canc Inst, Amsterdam, Netherlands. [Altamura, Louis A.] US Army Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD USA. [Doms, Robert W.] Childrens Hosp Philadelphia, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA. [Brummelkamp, Thijn R.] Canc Genom Ctr, Utrecht, Netherlands. [Wojcechowskyj, Jason A.] Gladstone Inst, San Francisco, CA USA. [Wojcechowskyj, Jason A.] Univ Calif San Francisco, San Francisco, CA 94143 USA. RP Wojcechowskyj, JA (reprint author), Univ Penn, Dept Microbiol, Perelman Sch Med, Philadelphia, PA 19104 USA. EM Jason.Wojcechowskyj@ucsf.edu FU HHS \ National Institutes of Health (NIH) [U54AI057168]; EC \ European Research Council (ERC) [ERC-2012-StG 309634]; Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO) [91711316] FX This work was funded by HHS vertical bar National Institutes of Health (NIH) under grant U54AI057168. EC vertical bar European Research Council (ERC) provided funding to Thijn R. Brummelkamp under grant number ERC-2012-StG 309634. Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO) provided funding to Thijn R. Brummelkamp under grant number 91711316. NR 63 TC 4 Z9 4 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X EI 1098-5514 J9 J VIROL JI J. Virol. PD FEB PY 2016 VL 90 IS 3 BP 1414 EP 1423 DI 10.1128/JVI.02055-15 PG 10 WC Virology SC Virology GA DC3WW UT WOS:000369150800022 PM 26581979 ER PT J AU Torre, C Camacho, M Liu, SYC Huon, LK Capasso, R AF Torre, Carlos Camacho, Macario Liu, Stanley Yung-Chuan Huon, Leh-Kiong Capasso, Robson TI Epiglottis collapse in adult obstructive sleep apnea: A systematic review SO LARYNGOSCOPE LA English DT Review DE Obstructive Sleep Apnea; epiglottis; hypopharynx; systematic review; surgery; snoring; positional therapy; continuous positive airway pressure ID POSITIVE AIRWAY PRESSURE; TRANSORAL ROBOTIC SURGERY; SIMPLE SURGICAL REMEDY; MULTILEVEL SURGERY; ACQUIRED LARYNGOMALACIA; FLOPPY EPIGLOTTIS; ENDOSCOPY; UVULOPALATOPHARYNGOPLASTY; THERAPY; CPAP AB Objectives/HypothesisTo systematically review the international literature evaluating the role of the epiglottis in snoring and obstructive sleep apnea and to explore possible treatment options available. Data SourcesPubMed, Scopus, Embase, Google Scholar, Book Citation Index-Science, CINAHL, Conference Proceedings Citation Index-Science, The Cochrane Collaboration Databases, and Web of Science. Review MethodThe searches were performed from the first year of each database through March 5, 2015. ResultsFourteen studies about the prevalence of epiglottis collapse in obstructive sleep apnea (OSA) were found. Most involved drug-induced sleep endoscopy studies that indirectly reported their findings about epiglottis collapse. The data suggests that the prevalence of epiglottis collapse in OSA is higher than previously described. The epiglottis has been implicated in 12% of cases of snoring, and sound originating from it has a higher pitch than palatal snoring. Continuous positive pressure (CPAP) surgery and positional therapy in the treatment of epiglottis collapse were also considered. Lateral position of the head may reduce the frequency of epiglottis collapse. With regard to CPAP, available reports suggest that it may accentuate collapse of the epiglottis. Surgery may help reduce snoring in some patients with a lax epiglottis and improve OSA in patients undergoing multilevel surgery. ConclusionKnowledge regarding the role of the epiglottis in adult OSA and snoring patients is limited. The prevalence of this phenomenon in OSA seems to be greater than previously reported, and more research is needed to understand its role in OSA and the best way to treat it. C1 [Torre, Carlos; Liu, Stanley Yung-Chuan; Huon, Leh-Kiong; Capasso, Robson] Stanford Univ, Med Ctr, Dept Otolaryngol Head & Neck Surg, Div Sleep Surg, Stanford, CA 94305 USA. [Camacho, Macario] Stanford Hosp & Clin, Dept Psychiat & Behav Sci, Div Sleep Med, Stanford, CA USA. [Torre, Carlos; Camacho, Macario; Liu, Stanley Yung-Chuan; Capasso, Robson] Stanford Univ, Sch Med, Stanford, CA 94305 USA. [Camacho, Macario] Tripler Army Med Ctr, Dept Otolaryngol Head & Neck Surg, Div Sleep Surg & Med, Honolulu, HI 96859 USA. [Huon, Leh-Kiong] Cathay Gen Hosp, Dept Otolaryngol Head & Neck Surg, Taipei, Taiwan. [Huon, Leh-Kiong] Fu Jen Catholic Univ, Sch Med, Taipei, Taiwan. RP Torre, C (reprint author), Stanford Univ, Dept Otolaryngol Head & Neck Surg, Div Sleep Surg, 450 Broadway St,Pavil B,2nd Fl, Redwood City, CA 94063 USA. EM ctorreleon22@gmail.com OI Camacho, Macario/0000-0001-9200-9085 NR 45 TC 9 Z9 9 U1 2 U2 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0023-852X EI 1531-4995 J9 LARYNGOSCOPE JI Laryngoscope PD FEB PY 2016 VL 126 IS 2 BP 515 EP 523 DI 10.1002/lary.25589 PG 9 WC Medicine, Research & Experimental; Otorhinolaryngology SC Research & Experimental Medicine; Otorhinolaryngology GA DC1SX UT WOS:000368998200043 PM 26371602 ER PT J AU Beidleman, BA Fulco, CS Buller, MJ Andrew, SP Staab, JE Muza, SR AF Beidleman, Beth A. Fulco, Charles S. Buller, Mark J. Andrew, Sean P. Staab, Janet E. Muza, Stephen R. TI Quantitative Model of Sustained Physical Task Duration at Varying Altitudes SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE HYPOXIA; HYPOBARIC HYPOXIA; ALGORITHM; ENDURANCE PERFORMANCE; SUBMAXIMAL EXERCISE; UNACCLIMATIZED LOWLANDERS ID SEA-LEVEL; ENDURANCE PERFORMANCE; EXERCISE PERFORMANCE; RUNNING PERFORMANCE; HYPOXIA; CAPACITY; EXPOSURE; RUNNERS; MEN AB Purpose: The objective of this study is to develop a quantitative model that can be used before ascent to altitude (ALT) to predict how much longer a sustained physical task would take for unacclimatized individuals in the early hours of exposure. Methods: Using multiple linear regression, we analyzed time-trial (TT) performance on 95 unacclimatized men (n = 83) and women (n = 12) at sea level (SL) and at an ALT ranging from 2500 to 4300 m. The TT was initiated within 4 h of ascent to ALT. The independent variables known before ascent were as follows: ALT, age, height, weight, sex, SL peak oxygen uptake, SL task duration time, and body mass index (BMI) classification (normal weight vs overweight). The dependent variable was the percent increase in TT duration from SL to ALT. Results: The most significant factor in the model was ALT (P = 0.0001), followed by BMI classification (P = 0.0009) and the interaction between BMI classification and ALT (P = 0.003). The model is as follows: percent increase in TT duration = [100 + e((-1.517+1.323 (ALT)+3.124 (BMI class)-0.769 (ALT) (BMI class))]. The percent increase in TT duration in overweight individuals was 129% greater than for normal-weight individuals at 3000 m. However, as ALT increased beyond 3000 m, the disparity between groups decreased until 4050 m where the percent increase in TT duration became greater for normal-weight individuals. Conclusions: This model provides the first quantitative estimates of the percent increase in sustained physical task duration during initial exposure to a wide range of elevations. Because only two easily obtainable factors are required as inputs for the model (ALT and BMI classification), this model can be used by many unacclimatized individuals to better plan their activities at ALT. C1 [Beidleman, Beth A.; Fulco, Charles S.; Andrew, Sean P.; Staab, Janet E.; Muza, Stephen R.] US Army Res Inst Environm Med, Thermal & Mt Med Div, Natick, MA 01760 USA. [Buller, Mark J.] US Army Res Inst Environm Med, Biophys & Biomed Modelling Div, Natick, MA 01760 USA. RP Beidleman, BA (reprint author), US Army Res Inst Environm Med, Thermal & Mt Med Div, Natick, MA 01760 USA. EM beth.a.beidleman.civ@mail.mil FU US Army Medical Research and Materiel Command FX Funding was provided by the US Army Medical Research and Materiel Command NR 38 TC 1 Z9 1 U1 2 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD FEB PY 2016 VL 48 IS 2 BP 323 EP 330 DI 10.1249/MSS.0000000000000768 PG 8 WC Sport Sciences SC Sport Sciences GA DB8JX UT WOS:000368764100018 PM 26339725 ER PT J AU Turney, SG Ahmed, M Chandrasekar, I Wysolmerski, RB Goeckeler, ZM Rioux, RM Whitesides, GM Bridgman, PC AF Turney, Stephen G. Ahmed, Mostafa Chandrasekar, Indra Wysolmerski, Robert B. Goeckeler, Zoe M. Rioux, Robert M. Whitesides, George M. Bridgman, Paul C. TI Nerve growth factor stimulates axon outgrowth through negative regulation of growth cone actomyosin restraint of microtubule advance SO MOLECULAR BIOLOGY OF THE CELL LA English DT Article ID MYOSIN-II ACTIVITY; CELL-ADHESION MOLECULE; END-BINDING-PROTEIN; F-ACTIN FLOW; NEURITE OUTGROWTH; COMPARTMENTALIZED CULTURES; SYMPATHETIC NEURONS; FLUORESCENT PROTEIN; RETROGRADE FLOW; TRKA RECEPTOR AB Nerve growth factor (NGF) promotes growth, differentiation, and survival of sensory neurons in the mammalian nervous system. Little is known about how NGF elicits faster axon outgrowth or how growth cones integrate and transform signal input to motor output. Using cultured mouse dorsal root ganglion neurons, we found that myosin II (MII) is required for NGF to stimulate faster axon outgrowth. From experiments inducing loss or gain of function of MII, specific MII isoforms, and vinculin-dependent adhesion-cytoskeletal coupling, we determined that NGF causes decreased vinculin-dependent actomyosin restraint of microtubule advance. Inhibition of MII blocked NGF stimulation, indicating the central role of restraint in directed outgrowth. The restraint consists of myosin IIB- and IIA-dependent processes: retrograde actin network flow and transverse actin bundling, respectively. The processes differentially contribute on laminin-1 and fibronectin due to selective actin tethering to adhesions. On laminin-1, NGF induced greater vinculin-dependent adhesion-cytoskeletal coupling, which slowed retrograde actin network flow (i.e., it regulated the molecular clutch). On fibronectin, NGF caused inactivation of myosin IIA, which negatively regulated actin bundling. On both substrates, the result was the same: NGF-induced weakening of MII-dependent restraint led to dynamic microtubules entering the actin-rich periphery more frequently, giving rise to faster elongation. C1 [Turney, Stephen G.] Harvard Univ, Ctr Brain Sci, Cambridge, MA 02138 USA. [Turney, Stephen G.] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA. [Rioux, Robert M.; Whitesides, George M.] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA. [Ahmed, Mostafa; Chandrasekar, Indra; Bridgman, Paul C.] Washington Univ, Sch Med, Dept Neurosci, St Louis, MO 63110 USA. [Wysolmerski, Robert B.; Goeckeler, Zoe M.] W Virginia Univ, Sch Med, Dept Neurobiol & Anat, Morgantown, WV 26506 USA. [Ahmed, Mostafa] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Chandrasekar, Indra] Sanford Res, Sanford Childrens Hlth Res Ctr, Sioux Falls, SD 57104 USA. [Rioux, Robert M.] Penn State Univ, Dept Chem Engn, University Pk, PA 16802 USA. RP Bridgman, PC (reprint author), Washington Univ, Sch Med, Dept Neurosci, St Louis, MO 63110 USA. EM bridgmap@pcg.wustl.edu FU National Institutes of Health [R21 MH081260, R21 EB9776, HL-090937, P20RR016440, 1 F32 NS60356-01]; Bakewell Neuroimaging Core, an imaging facility by Bakewell Family Foundation; National Institutes of Health Neuroscience Blueprint Interdisciplinary Center Core Grant [P30 (NS057105)]; Department of Molecular and Cellular Biology, Harvard University; National Science Foundation [ECS-0335765] FX This research was supported by grants to P.C.B. from National Institutes of Health (R21 MH081260, R21 EB9776) and in part by the Bakewell Neuroimaging Core, an imaging facility supported by the Bakewell Family Foundation and National Institutes of Health Neuroscience Blueprint Interdisciplinary Center Core Grant P30 (NS057105) to Washington University. S.G.T. receives support from Jeff Lichtman and the Department of Molecular and Cellular Biology, Harvard University. R.B.W. was supported by grants from the National Institutes of Health (HL-090937, P20RR016440). The fabrication of microfluidics devices was performed in part at the Center for Nanoscale Systems, a member of the National Nanotechnology Infrastructure Network, which is supported by the National Science Foundation under award ECS-0335765. The Center for Nanoscale Systems is part of the Faculty of Arts and Sciences, Harvard University. R.M.R. received a postdoctoral fellowship (1 F32 NS60356-01) from the National Institutes of Health. NR 66 TC 2 Z9 3 U1 2 U2 12 PU AMER SOC CELL BIOLOGY PI BETHESDA PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA SN 1059-1524 EI 1939-4586 J9 MOL BIOL CELL JI Mol. Biol. Cell PD FEB 1 PY 2016 VL 27 IS 3 BP 500 EP 517 DI 10.1091/mbc.E15-09-0636 PG 18 WC Cell Biology SC Cell Biology GA DC3NY UT WOS:000369127200009 PM 26631553 ER PT J AU Mrozek, RA Berg, MC Gold, CS Leighliter, B Morton, JT Lenhart, JL AF Mrozek, Randy A. Berg, Michael C. Gold, Christopher S. Leighliter, Brad Morton, Jeffrey T. Lenhart, Joseph L. TI Highly compliant shape memory polymer gels for tunable damping and reversible adhesion SO SMART MATERIALS AND STRUCTURES LA English DT Article DE shape memory polymer; reversible damping; polymer gel ID BIOMEDICAL APPLICATIONS; MECHANICAL-PROPERTIES; GRANULAR MEDIA; ACRYLIC-ACID; HYDROGELS; NETWORKS; BEHAVIOR; ROBOT; SURFACES; RHEOLOGY AB Materials that can dynamically change their properties to better adapt to the local environment have potential utility in robotics, aerospace, and coatings. For some of these applications, most notably robotics, it is advantageous for these responsive materials to be highly compliant in an effort to provide dynamic changes in adhesion and mechanical damping within a broad temperature operational environment. In this report, non-aqueous, highly compliant shape-memory polymer gels are developed by incorporating a low density of chemical cross-links into a physically cross-linked thermoplastic elastomer gel. Chemical cross-linkers were evaluated by varying there size and degree of functionality to determine the impact on the mechanical and adhesive properties. As a result of the chemical cross-linking, the gels exhibit modulus plateaus around room temperature and at elevated temperatures above 100 degrees C, where the thermoplastic elastomer gel typically melts. The materials were designed so that moduli in the plateaued regions were above and below the Dahlquist criteria of 4 x 10(4) Pa, respectively, where materials with a modulus below this value typically exhibit an increase in adhesion. The shape memory polymer gels were also integrated into fiber-reinforced composites to determine the temperature-dependent changes in mechanical damping. It is anticipated that this work will provide insight into materials design to provide dynamic changes in adhesion and damping to improve robotic appendage manipulation and platform mobility. C1 [Mrozek, Randy A.; Berg, Michael C.; Gold, Christopher S.; Leighliter, Brad; Lenhart, Joseph L.] US Army Res Lab, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21904 USA. [Morton, Jeffrey T.] Florida A&M Florida State Univ, 2003 Levy Ave, Tallahassee, FL 32310 USA. RP Mrozek, RA; Lenhart, JL (reprint author), US Army Res Lab, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21904 USA. EM randy.a.mrozek.civ@mail.mil; joseph.l.lenhart.civ@mail.mil NR 50 TC 0 Z9 0 U1 12 U2 38 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0964-1726 EI 1361-665X J9 SMART MATER STRUCT JI Smart Mater. Struct. PD FEB PY 2016 VL 25 IS 2 AR 025004 DI 10.1088/0964-1726/25/2/025004 PG 10 WC Instruments & Instrumentation; Materials Science, Multidisciplinary SC Instruments & Instrumentation; Materials Science GA DB9CP UT WOS:000368814100006 ER PT J AU Torres, OB Antoline, JFG Li, FY Jalah, R Jacobson, AE Rice, KC Alving, CR Matyas, GR AF Torres, Oscar B. Antoline, Joshua F. G. Li, Fuying Jalah, Rashmi Jacobson, Arthur E. Rice, Kenner C. Alving, Carl R. Matyas, Gary R. TI A simple nonradioactive method for the determination of the binding affinities of antibodies induced by hapten bioconjugates for drugs of abuse SO ANALYTICAL AND BIOANALYTICAL CHEMISTRY LA English DT Article DE Heroinhapten; Competition ELISA; Equilibrium dialysis; UPLC/MS/MS; Apparent dissociation constant (K-d); Antibody affinity ID LINKED IMMUNOSORBENT ASSAY; SIMPLE CHEMICAL-COMPOUNDS; MINIMAL CROSS-REACTIVITY; DIACETYLMORPHINE HEROIN; MONOCLONAL-ANTIBODIES; MASS-SPECTROMETRY; MORPHINE; RADIOIMMUNOASSAY; VACCINE; SPECIFICITY AB The accurate analytical measurement of binding affinities of polyclonal antibody in sera to heroin, 6-acetylmorphine (6-AM), and morphine has been a challenging task. A simple nonradioactive method that uses deuterium-labeled drug tracers and equilibrium dialysis (ED) combined with ultra performance liquid chromatography/tandem mass spectrometry (UPLC/MS/MS) to measure the apparent dissociation constant (K (d)) of antibodies to 6-AM and morphine is described. The method can readily detect antibodies with K (d) in the low nanomolar range. Since heroin is rapidly degraded in sera, esterase inhibitors were included in the assay, greatly reducing heroin hydrolysis. MS/MS detection directly measured the heroin in the assay after overnight ED, thereby allowing the quantitation of % bound heroin in lieu of K (d) as an alternative measurement to assess heroin binding to polyclonal antibody sera. This is the first report that utilizes a solution-based assay to quantify heroin-antibody binding without being confounded by the presence of 6-AM and morphine and to measure K (d) of polyclonal antibody to 6-AM. Hapten surrogates 6-AcMorHap, 6-PrOxyHap, MorHap, DiAmHap, and DiPrOxyHap coupled to tetanus toxoid (TT) were used to generate high affinity antibodies to heroin, 6-AM, and morphine. In comparison to competition ED-UPLC/MS/MS which gave K (d) values in the nanomolar range, the commonly used competition enzyme-linked immunosorbent assay (ELISA) measured the 50 % inhibition concentration (IC50) values in the micromolar range. Despite the differences in K (d) and IC50 values, similar trends in affinities of hapten antibodies to heroin, 6-AM, and morphine were observed by both methods. Competition ED-UPLC/MS/MS revealed that among the five TT-hapten bioconjugates, TT-6-AcMorHap and TT-6-PrOxyHap induced antibodies that bound heroin, 6-AM, and morphine. In contrast, TT-MorHap induced antibodies that poorly bound heroin, while TT-DiAmHap and TT-DiPrOxyHap induced antibodies either did not bind or poorly bound to heroin, 6-AM, and morphine. This simple and nonradioactive method can be extended to other platforms, such as oxycodone, cocaine, nicotine, and methamphetamine for the selection of the lead hapten design during substance abuse vaccine development. C1 [Torres, Oscar B.; Jalah, Rashmi; Alving, Carl R.; Matyas, Gary R.] Walter Reed Army Inst Res, Lab Adjuvant & Antigen Res, US Mil HIV Res Program, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. [Torres, Oscar B.; Jalah, Rashmi] Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, 6720A Rockledge Dr, Bethesda, MD 20817 USA. [Antoline, Joshua F. G.; Li, Fuying; Jacobson, Arthur E.; Rice, Kenner C.] NIDA, Drug Design & Synth Sect, Mol Targets & Medicat Discovery Branch, NIH,US Dept HHS, 9800 Med Dr, Bethesda, MD 20892 USA. [Antoline, Joshua F. G.; Li, Fuying; Jacobson, Arthur E.; Rice, Kenner C.] NIAAA, NIH, 9800 Med Dr, Bethesda, MD 20892 USA. [Li, Fuying] WuXi AppTec Shanghai Co Ltd, 288 FuTe Rd, Shanghai 200131, Peoples R China. RP Matyas, GR (reprint author), Walter Reed Army Inst Res, Lab Adjuvant & Antigen Res, US Mil HIV Res Program, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM gmatyas@hivresearch.org OI Matyas, Gary/0000-0002-2074-2373 FU Intramural NIH HHS; NIDA NIH HHS [1DP1DA034787-01, DP1 DA034787] NR 50 TC 1 Z9 1 U1 5 U2 19 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1618-2642 EI 1618-2650 J9 ANAL BIOANAL CHEM JI Anal. Bioanal. Chem. PD FEB PY 2016 VL 408 IS 4 BP 1191 EP 1204 DI 10.1007/s00216-015-9223-z PG 14 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA DB7TZ UT WOS:000368720600016 PM 26677020 ER PT J AU Voloshinov, VB Gupta, N Kulakova, LA Khorkin, VS Melekh, BT Knyazev, GA AF Voloshinov, V. B. Gupta, N. Kulakova, L. A. Khorkin, V. S. Melekh, B. T. Knyazev, G. A. TI Investigation of acousto-optic properties of tellurium-based glasses for infrared applications SO JOURNAL OF OPTICS LA English DT Article DE acousto-optics; tellurium-based glasses; infrared; optical transmission; figure of merit; modulation; deflection ID 10.6 MU-M; TUNABLE FILTER; CRYSTAL; PERFORMANCE; HG2CL2 AB We examined the physical properties of infrared optical glasses composed of tellurium, germanium, selenium, sulfur and silicon. In particular, we measured optical, acoustic and photoelastic parameters of the following alloy compounds: germanium-selenium-tellurium (Ge-Se- Te), germanium-selenium-sulfur-tellurium (Ge-Se-S-Te), germanium-silicon-tellurium (Ge-Si-Te) and silicon-tellurium (Si-Te). Like single-crystal tellurium, the glasses demonstrate good acousto-optic (AO) diffraction efficiency and have reasonable optical transparency in a wide spectral region covering wavelengths from 1.5 to 20 mu m. The optical, acoustic and photoelastic properties of the tellurium-based compounds were measured using infrared lamp sources of radiation as well as He-Ne and CO2 lasers. In this paper, we report on the optical, acoustic and photoelastic parameters of a selection of these compounds and discuss the advantages and disadvantages of using these glasses for AO device applications. We also present the measured characteristics of an AO cell fabricated in a Si20Te80 glass material which exhibited high optical uniformity and long-term chemical stability. C1 [Voloshinov, V. B.; Khorkin, V. S.; Knyazev, G. A.] Moscow MV Lomonosov State Univ, Fac Phys, Moscow 199991, Russia. [Gupta, N.] US Army, Res Lab, Adelphi, MD 20783 USA. [Kulakova, L. A.; Melekh, B. T.] AF Ioffe Phys Tech Inst, St Petersburg 194021, Russia. RP Voloshinov, VB (reprint author), Moscow MV Lomonosov State Univ, Fac Phys, Moscow 199991, Russia. EM volosh@phys.msu.ru; neelam.gupta.civ@mail.mil; L.Kulakova@mail.ioffe.ru FU [RUP1-31167-MO-13] FX The research in Russia was supported by the grant RUP1-31167-MO-13 issued by CRDF Global. NR 28 TC 1 Z9 1 U1 2 U2 10 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 2040-8978 EI 2040-8986 J9 J OPTICS-UK JI J. Opt. PD FEB PY 2016 VL 18 IS 2 AR 025402 DI 10.1088/2040-8978/18/2/025402 PG 9 WC Optics SC Optics GA DB1IO UT WOS:000368262000020 ER PT J AU Haenisch, F Cooper, JD Reif, A Kittel-Schneider, S Steiner, J Leweke, FM Rothermundt, M van Beveren, NJM Crespo-Facorro, B Niebuhr, DW Cowan, DN Weber, NS Yolken, RH Penninxi, BWJH Bahn, S AF Haenisch, Frieder Cooper, Jason D. Reif, Andreas Kittel-Schneider, Sarah Steiner, Johann Leweke, F. Markus Rothermundt, Matthias van Beveren, Nico J. M. Crespo-Facorro, Benedicto Niebuhr, David W. Cowan, David N. Weber, Natalya S. Yolken, Robert H. Penninxi, Brenda W. J. H. Bahn, Sabine TI Towards a blood-based diagnostic panel for bipolar disorder SO BRAIN BEHAVIOR AND IMMUNITY LA English DT Article DE Bipolar disorder; Multiplex immunoassay; Biomarker; Differential diagnosis; Diagnostic test ID MULTIPLE-SCLEROSIS LESIONS; MATRIX METALLOPROTEINASES; EXPRESSION; SCHIZOPHRENIA; DYSFUNCTION; BIOMARKERS; IMBALANCE; MONOCYTES; BARRIER; SYSTEM AB Background: Bipolar disorder (BD) is a costly, devastating and life shortening mental disorder that is often misdiagnosed, especially on initial presentation. Misdiagnosis frequently results in ineffective treatment. We investigated the utility of a biomarker panel as a diagnostic test for BD. Methods and findings: We performed a meta-analysis of eight case-control studies to define a diagnostic biomarker panel for BD. After validating the panel on established BD patients, we applied it to undiagnosed BD patients. We analysed 249 BD, 122 pre-diagnostic BD, 75 pre-diagnostic schizophrenia and 90 first onset major depression disorder (MDD) patients and 371 controls. The biomarker panel was identified using ten-fold cross-validation with lasso regression applied to the 87 analytes available across the meta-analysis studies. We identified 20 protein analytes with excellent predictive performance [area under the curve (AUC) >= 0.90]. Importantly, the panel had a good predictive performance (AUC 0.84) to differentiate 12 misdiagnosed BD patients from 90 first onset MDD patients, and a fair to good predictive performance (AUC 0.79) to differentiate between 110 pre-diagnostic BD patients and 184 controls. We also demonstrated the disease specificity of the panel. Conclusions: An early and accurate diagnosis has the potential to delay or even prevent the onset of BD. This study demonstrates the potential utility of a biomarker panel as a diagnostic test for BD. (C) 2015 The Authors. Published by Elsevier Inc. C1 [Haenisch, Frieder; Cooper, Jason D.; Bahn, Sabine] Univ Cambridge, Dept Chem Engn & Biotechnol, Cambridge, England. [Reif, Andreas; Kittel-Schneider, Sarah] Goethe Univ Hosp Frankfurt, Dept Psychiat Psychosomat Med & Psychotherapy, Frankfurt, Germany. [Steiner, Johann] Univ Magdeburg, Dept Psychiat Psychotherapy & Psychosomat Med, D-39106 Magdeburg, Germany. [Leweke, F. Markus] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Mannheim, Germany. [Rothermundt, Matthias] Univ Munster, Dept Psychiat, Munster, Germany. [van Beveren, Nico J. M.] Erasmus Univ, Med Ctr, Dept Psychiat, Rotterdam, Netherlands. [Crespo-Facorro, Benedicto] Univ Cantabria, IDIVAL, Univ Hosp Marques de Valdecilla, CIBERSAM,Dept Psychiat, E-39005 Santander, Spain. [Niebuhr, David W.; Cowan, David N.; Weber, Natalya S.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Yolken, Robert H.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. [Penninxi, Brenda W. J. H.] Vrije Univ Amsterdam, Med Ctr, EMGO Inst, Dept Psychiat, Amsterdam, Netherlands. RP Bahn, S (reprint author), Univ Cambridge, Dept Chem Engn & Biotechnol, Cambridge, England. EM sb209@cam.ac.uk OI Haenisch, Frieder/0000-0001-7961-4467; Kittel-Schneider, Sarah/0000-0003-3057-6150 FU Stanley Medical Research Institute [07R-1888]; Netherlands Organisation for Health Research and Development (Zon-Mw) [10-000-1002]; VU University Medical Center; Leiden University Medical Center; University Medical Center Groningen; Stanley Medical Research Institute; US Department of the Army FX We gratefully acknowledge support by the Stanley Medical Research Institute (no. 07R-1888). The infrastructure for the NESDA study (www.nesda.nl) has been funded through the Geestkracht program of the Netherlands Organisation for Health Research and Development (Zon-Mw, grant number 10-000-1002) and participating universities (VU University Medical Center, Leiden University Medical Center, University Medical Center Groningen). DNC, DWN and NSW efforts were funded by the Stanley Medical Research Institute and the US Department of the Army. The funding organizations had no role in the design and conduct of the study; the collection, management, analysis, and interpretation of the data; or the preparation or approval of the manuscript. The views expressed are those of the authors and should not be construed to represent the positions of the funding bodies including the US Department of the Army or Department of Defense. NR 43 TC 5 Z9 5 U1 3 U2 12 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0889-1591 EI 1090-2139 J9 BRAIN BEHAV IMMUN JI Brain Behav. Immun. PD FEB PY 2016 VL 52 BP 49 EP 57 DI 10.1016/j.bbi.2015.10.001 PG 9 WC Immunology; Neurosciences SC Immunology; Neurosciences & Neurology GA DB2DB UT WOS:000368317400008 PM 26441135 ER PT J AU Vidal-Dorsch, DE Bay, SM Moore, S Layton, B Mehinto, AC Vulpe, CD Brown-Augustine, M Loguinov, A Poynton, H Garcia-Reyero, N Perkins, EJ Escalon, L Denslow, ND Cristina, CDR Doan, T Shukradas, S Bruno, J Brown, L Van Agglen, G Jackman, P Bauer, M AF Vidal-Dorsch, Doris E. Bay, Steven M. Moore, Shelly Layton, Blythe Mehinto, Alvine C. Vulpe, Chris D. Brown-Augustine, Marianna Loguinov, Alex Poynton, Helen Garcia-Reyero, Natalia Perkins, Edward J. Escalon, Lynn Denslow, Nancy D. Cristina, Colli-Dula R. Doan, Tri Shukradas, Shweta Bruno, Joy Brown, Lorraine Van Agglen, Graham Jackman, Paula Bauer, Megan TI Ecotoxicogenomics: Microarray interlaboratory comparability SO CHEMOSPHERE LA English DT Article DE Ecotoxicogenomics; Microarray; Gene expression; Intercalibration; Inter- and intra-laboratory reproducibility; Amphipod ID TOXICOGENOMICS; PLATFORMS; ISSUES AB Transcriptomic analysis can complement traditional ecotoxicology data by providing mechanistic insight, and by identifying sub-lethal organismal responses and contaminant classes underlying observed toxicity. Before transcriptomic information can be used in monitoring and risk assessment, it is necessary to determine its reproducibility and detect key steps impacting the reliable identification of differentially expressed genes. A custom 15K-probe microarray was used to conduct transcriptomics analyses across six laboratories with estuarine amphipods exposed to cyfluthrin-spiked or control sediments (10 days). Two sample types were generated, one consisted of total RNA extracts (Ex) from exposed and control samples (extracted by one laboratory) and the other consisted of exposed and control whole body amphipods (WB) from which each laboratory extracted RNA. Our findings indicate that gene expression microarray results are repeatable. Differentially expressed data had a higher degree of repeatability across all laboratories in samples with similar RNA quality (Ex) when compared to WB samples with more variable RNA quality. Despite such variability a subset of genes were consistently identified as differentially expressed across all laboratories and sample types. We found that the differences among the individual laboratory results can be attributed to several factors including RNA quality and technical expertise, but the overall results can be improved by following consistent protocols and with appropriate training. Published by Elsevier Ltd. C1 [Vidal-Dorsch, Doris E.; Bay, Steven M.; Moore, Shelly; Layton, Blythe; Mehinto, Alvine C.] Southern Calif Coastal Water Res Project, Costa Mesa, CA 92626 USA. [Vulpe, Chris D.; Brown-Augustine, Marianna; Loguinov, Alex] Univ Calif Berkeley, Berkeley, CA 94720 USA. [Poynton, Helen] Univ Massachusetts, Boston, MA 02125 USA. [Garcia-Reyero, Natalia] Mississippi State Univ, Starkville, MS USA. [Garcia-Reyero, Natalia; Perkins, Edward J.; Escalon, Lynn] US Army Engn Res & Dev Ctr, Vicksburg, MS USA. [Denslow, Nancy D.; Cristina, Colli-Dula R.] Univ Florida, Gainesville, FL USA. [Cristina, Colli-Dula R.] Inst Politecn Nacl, Ctr Invest & Estudios Avanzados, Merida, Mexico. [Doan, Tri; Shukradas, Shweta] Agilent Technol, Santa Clara, CA USA. [Shukradas, Shweta] Strand Sci Intelligence Inc, San Francisco, CA USA. [Bruno, Joy; Brown, Lorraine; Van Agglen, Graham] Environm Canada, N Vancouver, BC, Canada. [Jackman, Paula; Bauer, Megan] Environm Canada, Moncton, NB, Canada. RP Vidal-Dorsch, DE (reprint author), Southern Calif Coastal Water Res Project, 3535 Harbor Blvd Suite 110, Costa Mesa, CA 92626 USA. EM dorisv@sccwrp.org FU Environment Canada for Minister of Environment [1301230] FX The authors wish to acknowledge the efforts of their staff and those of collaborating organizations, which have been instrumental to the success of this project. We thank SCCWRP staff Darrin Greenstein, Patricia Gonzalez, Fernando Vargas and Mary-Caitlin Jordan for conducting the laboratory exposures and coordinating sample storage and transfer. The authors would like to thank Agilent staff for all their support in this project particularly, Sharon Henne and the Genomics staff. This study was funded in part by Environment Canada for the Minister of the Environment (Contribution No. 1301230). In kind support for this project was also provided by all the participating laboratories. NR 22 TC 2 Z9 2 U1 4 U2 13 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 EI 1879-1298 J9 CHEMOSPHERE JI Chemosphere PD FEB PY 2016 VL 144 BP 193 EP 200 DI 10.1016/j.chemosphere.2015.08.019 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA DA4MQ UT WOS:000367774400026 PM 26363320 ER PT J AU Mark, N Arthur, J Dontsova, K Brusseau, M Taylor, S AF Mark, Noah Arthur, Jennifer Dontsova, Katerina Brusseau, Mark Taylor, Susan TI Adsorption and attenuation behavior of 3-nitro-1,2,4-triazol-5-one (NTO) in eleven soils SO CHEMOSPHERE LA English DT Article DE NTO; Soil adsorption; Insensitive munitions; Energetic materials ID CONSTITUENTS 2,4-DINITROANISOLE DNAN; INSENSITIVE MUNITIONS FORMULATIONS; ORGANIC-CARBON; CLAY-MINERALS; DISSOLUTION; SORPTION; NITROGUANIDINE; EXPLOSIVES; ACID; TNT AB NTO (3-nitro-1,2,4-triazol-5-one) is one of the new explosive compounds used in insensitive munitions (IM) developed to replace traditional explosives, TNT and RDX. Data on NTO fate and transport is needed to determine its environmental behavior and potential for groundwater contamination. We conducted a series of kinetic and equilibrium batch experiments to characterize the fate of NTO in soils and the effect of soil geochemical properties on NTO-soil interactions. A set of experiments was also conducted using sterilized soils to evaluate the contribution of biodegradation to NTO attenuation. Measured pH values for NTO solutions decreased from 5.98+/-0.13 to 3.50+/-0.06 with increase in NTO concentration from 0.78 to 100 mg L-1. Conversely, the pH of soil suspensions was not significantly affected by NTO in this concentration range. NTO experienced minimal adsorption, with measured adsorption coefficients being less than 1 cm(3) g(-1) for all studied soils. There was a highly significant inverse relationship between the measured NTO adsorption coefficients and soil pH (P = 0.00011), indicating the role of NTO and soil charge in adsorption processes. In kinetic experiments, 1st order transformation rate constant estimates ranged between 0.0004 h(-1) and 0.0142 h(-1) (equivalent to half-lives of 72 and 2 d, respectively), and correlated positively with organic carbon in the soil. Total attenuation of NTO was higher in untreated versus sterilized samples, suggesting that NTO was being biodegraded. The information presented herein can be used to help evaluate NTO potential for natural attenuation in soils. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Mark, Noah; Arthur, Jennifer; Dontsova, Katerina; Brusseau, Mark] Univ Arizona, Dept Soil Water & Environm Sci, Tucson, AZ 85721 USA. [Dontsova, Katerina] Univ Arizona, Biosphere 2, Tucson, AZ 85721 USA. [Taylor, Susan] US Army Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Dontsova, K (reprint author), Univ Arizona, Marshall Bldg,Room 523,845 N,Pk Ave, Tucson, AZ 85721 USA. EM dontsova@email.arizona.edu FU Strategic Environmental Research and Development Program, SERDP [ER-2220] FX This work was funded by the Strategic Environmental Research and Development Program, SERDP, project ER-2220. We are grateful to Anthony Di Stasio and Erika Rivera, US Army Armament Research, Development and Engineering Center (ARDEC), Picatinny Arsenal for providing NTO; Bonnie M. Packer, Rosa Gwinn, Lisa DeGrazia, Bethany Keller, Jessica Milose, Amibeth Sheridan, Laurie Stenberg, Sarah Gettier, Army National Guard-Environmental Directorate and URS Corporation, Germantown, MD and Mike Heitmann, CH2M HILL Englewood, CO for collecting soils used in the experiments on Army National Guard installations. NR 41 TC 6 Z9 6 U1 8 U2 36 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 EI 1879-1298 J9 CHEMOSPHERE JI Chemosphere PD FEB PY 2016 VL 144 BP 1249 EP 1255 DI 10.1016/j.chemosphere.2015.09.101 PG 7 WC Environmental Sciences SC Environmental Sciences & Ecology GA DA4MQ UT WOS:000367774400156 PM 26473550 ER PT J AU Brett-Major, DM Frick, KD Malia, JA Hakre, S Okulicz, JF Beckett, CG Jagodinski, LL Forgione, MA Gould, PL Harrison, SA Murray, CK Rentas, FJ Armstrong, AW Hayat, AM Pacha, LA Dawson, P Eick-Cost, AA Maktabi, HH Michael, NL Cersovsky, SB Peel, SA Scott, PT AF Brett-Major, David M. Frick, Kevin D. Malia, Jennifer A. Hakre, Shilpa Okulicz, Jason F. Beckett, Charmagne G. Jagodinski, Linda L. Forgione, Michael A. Gould, Philip L. Harrison, Stephen A. Murray, Clinton K. Rentas, Francisco J. Armstrong, Adam W. Hayat, Aatif M. Pacha, Laura A. Dawson, Peter Eick-Cost, Angelia A. Maktabi, Hala H. Michael, Nelson L. Cersovsky, Steven B. Peel, Sheila A. Scott, Paul T. TI Costs and Consequences: Hepatitis C Seroprevalence in the Military and Its Impact on Potential Screening Strategies SO HEPATOLOGY LA English DT Article ID TASK-FORCE RECOMMENDATION; VIRUS-INFECTION; UNITED-STATES; WHOLE-BLOOD; SOFOSBUVIR; REGIMENS AB Knowledge of the contemporary epidemiology of hepatitis C viral (HCV) infection among military personnel can inform potential Department of Defense screening policy. HCV infection status at the time of accession and following deployment was determined by evaluating reposed serum from 10,000 service members recently deployed to combat operations in Iraq and Afghanistan in the period 2007-2010. A cost model was developed from the perspective of the Department of Defense for a military applicant screening program. Return on investment was based on comparison between screening program costs and potential treatment costs avoided. The prevalence of HCV antibody-positive and chronic HCV infection at accession among younger recently deployed military personnel born after 1965 was 0.98/1000 (95% confidence interval 0.45-1.85) and 0.43/1000 (95% confidence interval 0.12-1.11), respectively. Among these, service-related incidence was low; 64% of infections were present at the time of accession. With no screening, the cost to the Department of Defense of treating the estimated 93 cases of chronic HCV cases from a single year's accession cohort was $9.3 million. Screening with the HCV antibody test followed by the nucleic acid test for confirmation yielded a net annual savings and a $3.1 million dollar advantage over not screening. Conclusions: Applicant screening will reduce chronic HCV infection in the force, result in a small system costs savings, and decrease the threat of transfusion-transmitted HCV infection in the battlefield blood supply and may lead to earlier diagnosis and linkage to care; initiation of an applicant screening program will require ongoing evaluation that considers changes in the treatment cost and practice landscape, screening options, and the epidemiology of HCV in the applicant/accession and overall force populations. C1 [Brett-Major, David M.] Naval Med Res Ctr, Infect Dis Directorate, Silver Spring, MD USA. [Brett-Major, David M.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD USA. [Frick, Kevin D.] Johns Hopkins Univ, Carey Business Sch, Baltimore, MD USA. [Malia, Jennifer A.] US Mil HIV Res Program, Walter Reed Army Inst Res, Silver Spring, MD USA. [Hakre, Shilpa] Henry M Jackson Fdn, US Mil HIV Res Program, Bethesda, MD USA. [Okulicz, Jason F.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. [Beckett, Charmagne G.] Navy Bloodborne Infect Management Ctr, Bethesda, MD USA. [Gould, Philip L.] US Air Force Surg Gen Off, Falls Church, VA USA. [Rentas, Francisco J.] Armed Serv Blood Program Off, Falls Church, VA USA. [Rentas, Francisco J.] US Army Blood Program, Falls Church, VA USA. Navy Med Res Unit 6, Lima, Peru. [Armstrong, Adam W.] US Army Publ Hlth Ctr Provisional, Aberdeen Proving Ground, MD USA. [Hayat, Aatif M.; Pacha, Laura A.; Cersovsky, Steven B.] Emmes Corp, Rockville, MD USA. [Dawson, Peter] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD USA. [Eick-Cost, Angelia A.] Henry M Jackson Fdn, Bethesda, MD USA. [Eick-Cost, Angelia A.] Vet Adm, Off Med Inspector, Washington, DC USA. RP Brett-Major, DM (reprint author), NMRC, 503 Robert Grant Ave, Silver Spring, MD USA. EM david.m.brett.mil@mail.mil FU OCONUS Contingency Operations funds from the US Department of Defense FX Supported by OCONUS Contingency Operations funds from the US Department of Defense. NR 22 TC 1 Z9 1 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0270-9139 EI 1527-3350 J9 HEPATOLOGY JI Hepatology PD FEB PY 2016 VL 63 IS 2 BP 398 EP 407 DI 10.1002/hep.28303 PG 10 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA EL6VS UT WOS:000394761100011 PM 26481723 ER PT J AU Coleman, SP Tschopp, MA Weinberger, CR Spearot, DE AF Coleman, Shawn P. Tschopp, Mark A. Weinberger, Christopher R. Spearot, Douglas E. TI Bridging atomistic simulations and experiments via virtual diffraction: understanding homophase grain boundary and heterophase interface structures SO JOURNAL OF MATERIALS SCIENCE LA English DT Article ID STRUCTURE-ENERGY CORRELATION; X-RAY-DIFFRACTION; FCC METALS; MOLECULAR-DYNAMICS; TILT BOUNDARIES; GOLD; ALUMINUM; ANGLE; DEFORMATION; NUCLEATION AB Virtual diffraction is a computational technique that enables a synergistic coupling between experiments and atomistic simulations, which can help to elucidate nanoscale structure-property relationships. The research objective herein is to highlight recent advances in the use of virtual diffraction as a method to study the geometry and structure of homophase grain boundaries and heterophase interfaces with direct experimental validation. Virtual selected area diffraction patterns for two types of boundaries-homophase Al twist grain boundaries and heterophase Al2O3/Al interfaces-are created without a priori assumption of the periodic interface structure by computing diffraction intensities across high-resolution, 3-D reciprocal space meshes. In this work, computed diffraction patterns clearly identify Al grain boundary misorientation angles, reveal subsidiary peaks created by the dislocation arrays within select Al grain boundaries, and allow experimental validation of the minimum energy orientation relationship for the Al2O3/Al interface. Due to its advanced implementation, virtual diffraction characterization used throughout this work can be easily extended providing routes for similar analysis and experimental validation of atomistic simulations. C1 [Coleman, Shawn P.; Tschopp, Mark A.] US Army, Res Lab, Aberdeen, MD 21005 USA. [Weinberger, Christopher R.] Drexel Univ, Dept Mech Engn & Mech, Philadelphia, PA 19104 USA. [Spearot, Douglas E.] Univ Arkansas, Dept Mech Engn, Fayetteville, AR 72701 USA. RP Coleman, SP (reprint author), US Army, Res Lab, Aberdeen, MD 21005 USA. EM shawn.p.coleman8.ctr@mail.mil OI Tschopp, Mark/0000-0001-8471-5035 FU U.S. Army Research Laboratory; National Science Foundation [0954505, ACI1053575]; 21st Century Professorship in Mechanical Engineering at the University of Arkansas FX SPC acknowledges support by an appointment to Postdoctoral Fellowship at the U.S. Army Research Laboratory, administered by the Oak Ridge Institute for Science and Education. SPC and DES acknowledge support of the National Science Foundation under Grant #0954505. Additional support is provided by the 21st Century Professorship in Mechanical Engineering at the University of Arkansas. Simulations were run using the Extreme Science and Engineering Discovery Environment (XSEDE), which is supported by National Science Foundation Grant number ACI1053575. NR 45 TC 1 Z9 1 U1 3 U2 9 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0022-2461 EI 1573-4803 J9 J MATER SCI JI J. Mater. Sci. PD FEB PY 2016 VL 51 IS 3 BP 1251 EP 1260 DI 10.1007/s10853-015-9087-9 PG 10 WC Materials Science, Multidisciplinary SC Materials Science GA DA2GE UT WOS:000367612500008 ER PT J AU Vahedifard, F Robinson, JD Mason, GL Howard, IL Priddy, JD AF Vahedifard, Farshid Robinson, Joe D. Mason, George L. Howard, Isaac L. Priddy, Jody D. TI Mobility algorithm evaluation using a consolidated database developed for wheeled vehicles operating on dry sands SO JOURNAL OF TERRAMECHANICS LA English DT Article DE Mobility; Sand; Drawbar pull; Motion resistance; Sinkage; Vehicle Terrain Interface (VTI); Database AB A substantial number of laboratory and field tests have been conducted to assess performance of various wheel designs in loose soils. However, there is no consolidated database which includes data from several sources. In this study, a consolidated database was created on tests conducted with wheeled vehicles operating in loose dry sand to evaluate existing soil mobility algorithms. The database included wheels of different diameters, widths, heights, and inflation pressures, operating under varying loading conditions. Nine technical reports were identified containing 5253 records, based on existing archives of laboratory and field tests of wheels operating in loose soils. The database structure was assembled to include traction performance parameters such as drawbar pull, torque, traction, motion resistance, sinkage, and wheel slip. Once developed, the database was used to evaluate and support validation of closed form solutions for these variables in the Vehicle Terrain Interface (VTI) model. The correlation between predicted and measured traction performance parameters was evaluated. Comparison of the predicted versus measured performance parameters suggests that the closed form solutions within the VTI model are functional but can be further improved to provide more accurate predictions for off-road vehicle performance. (C) 2015 ISTVS. Published by Elsevier Ltd. All rights reserved. C1 [Vahedifard, Farshid; Robinson, Joe D.; Howard, Isaac L.] Mississippi State Univ, Dept Civil & Environm Engn, Mississippi State, MS 39762 USA. [Vahedifard, Farshid; Robinson, Joe D.; Mason, George L.] Mississippi State Univ, Ctr Adv Vehicular Syst CAVS, Mississippi State, MS 39762 USA. [Priddy, Jody D.] US Army Engineer Res & Dev Ctr ERDC, Vicksburg, MS 39180 USA. RP Vahedifard, F (reprint author), Mississippi State Univ, Dept Civil & Environm Engn, Mississippi State, MS 39762 USA. EM farshid@cee.msstate.edu; jdr418@msstate.edu; George.L.Mason.PE@engineer.com; ilhoward@cee.msstate.edu; Jody.D.Priddy@erdc.dren.mil FU U.S. Government [W15QKN-13-9-0001] FX This effort was sponsored by the U.S. Government under Other Transaction number W15QKN-13-9-0001 between the Consortium for Energy, Environment and Demilitarization, and the Government. The U.S. Government is authorized to reproduce and distribute reprints for Governmental purposes notwithstanding any copyright notation thereon. The views and conclusions contained herein are those of the authors and should not be interpreted as necessarily representing the official policies or endorsements, either expressed or implied, of the U.S. Government. The authors would like to thank Levi Weeks and Clinton Carlisle for their assistance in extracting data from various reports and assembling the database. This paper is based on the work conducted under Task 12: Mobility Modeling for Soils. Roger King, Director of the Center for Advanced Vehicular Systems (CAVS) at Mississippi State University, was principal investigator for W15QKN-13-9-0001 and Farshid Vahedifard was the lead for Task 12. NR 32 TC 2 Z9 2 U1 1 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4898 EI 1879-1204 J9 J TERRAMECHANICS JI J. Terramech. PD FEB PY 2016 VL 63 BP 13 EP 22 DI 10.1016/j.jterra.2015.10.002 PG 10 WC Engineering, Environmental SC Engineering GA DA4MP UT WOS:000367774300002 ER PT J AU Scenna, R Gupta, AK AF Scenna, Richard Gupta, Ashwani K. TI Partial oxidation of JP8 in a well-insulated distributed reactor SO FUEL PROCESSING TECHNOLOGY LA English DT Article DE Fuel reforming via partial oxidation; JP8; Non-catalytic fuel reforming; Distributed reaction regime; Hydrogen production ID FUELS AB Low temperature fuel reforming via partial oxidation in a distributed reactor has shown superior performances compared to other lower temperature approaches. Previous results and literature indicated higher reactor temperatures to yield superior results. The well-insulated reactor developed incorporated elements of the low temperature reactor design. The syngas obtained was of better quality in terms of gas species component present and the syngas heating value than that reported previously from a non-catalytic reformer. The syngas composition consisted of 19.2% hydrogen and 20.8% carbon monoxide and these values are higher than the previously reported data. Lower series of hydrocarbons (acetylene and propane) were only detected in trace amounts (less than 15 ppm). Elevated reactor temperatures promoted the dissociation of lower series of hydrocarbons (methane, acetylene, and ethylene), which provided additional syngas formation. The gas species concentrations obtained approached that of catalytic reforming. Flame regime was determined through numerical diagnostics. As reaction regime became less distributed with higher injection temperature, reformate quality was adversely impacted. The mitigation of thermal losses from the well-insulated reactor promoted superior reformer efficiency by allowing the reactor to achieve conditions not possible in low temperature reactors. (C) 2015 Elsevier B.V. All rights reserved. C1 [Scenna, Richard] US Army Res, Dev & Engn Command, CERDEC, CPI, Adelphi, MD USA. [Gupta, Ashwani K.] Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA. RP Gupta, AK (reprint author), Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA. EM akgupta@umd.edu FU United States Army's Research Development Engineering Command (RDECOM) Independent Laboratory Innovative Research (ILIR) program; US Army Communication Electronic Research Directorate Engineering Command (CERDEC) Command Power Integration (CPI) directorate; Reaction Design for the Chemkin FX The authors acknowledge the support of the United States Army's Research Development Engineering Command (RDECOM) Independent Laboratory Innovative Research (ILIR) program and US Army Communication Electronic Research Directorate Engineering Command (CERDEC) Command Power Integration (CPI) directorate. The authors also gratefully acknowledge the help and support provided by Reaction Design for the Chemkin code used here. NR 21 TC 2 Z9 2 U1 2 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-3820 EI 1873-7188 J9 FUEL PROCESS TECHNOL JI Fuel Process. Technol. PD FEB PY 2016 VL 142 BP 174 EP 181 DI 10.1016/j.fuproc.2015.10.014 PG 8 WC Chemistry, Applied; Energy & Fuels; Engineering, Chemical SC Chemistry; Energy & Fuels; Engineering GA CZ4XV UT WOS:000367107300020 ER PT J AU Martin, RF AF Martin, Ronald F. TI Alternative Considerations for Surgical Training and Funding SO SURGICAL CLINICS OF NORTH AMERICA LA English DT Article DE Surgical training; Funding; Graduate medical education; Alternatives ID EDUCATION AB Since the late 1880s, surgical residency programs have existed in forms that are similar to our current models. Many important variations have been introduced overtime. On aggregate this system has worked remarkably well; though as economic, demographic, and cultural changes continue to evolve, one must wonder if we were to change our models, how might we do that and what reasoning could we use. This article's focus is to take a stratospheric view of what could be done, particularly in the United States, rather than characterize what happens in other countries with other health economic systems. C1 [Martin, Ronald F.] Marshfield Clin Fdn Med Res & Educ, Marshfield, WI 54449 USA. [Martin, Ronald F.] St Josephs Hosp, Marshfield, WI 54449 USA. [Martin, Ronald F.] Univ Wisconsin, Sch Med & Publ Hlth, Dept Surg, Madison, WI 53726 USA. [Martin, Ronald F.] US Army Reserve, Med Corps, Worcester, MA USA. RP Martin, RF (reprint author), Marshfield Clin Fdn Med Res & Educ, 1000 North Oak Ave, Marshfield, WI 54449 USA. EM rmartin@yorkhospital.com NR 7 TC 0 Z9 0 U1 0 U2 2 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0039-6109 EI 1558-3171 J9 SURG CLIN N AM JI Surg. Clin.-North Am. PD FEB PY 2016 VL 96 IS 1 BP 35 EP + DI 10.1016/j.suc.2015.09.002 PG 13 WC Surgery SC Surgery GA CZ5DV UT WOS:000367123600006 PM 26612018 ER PT J AU Lanzillo, NA O'Regan, TP Nayak, SK AF Lanzillo, Nicholas A. O'Regan, Terrance P. Nayak, Saroj K. TI Band structure modulation in MoS2 multilayers and heterostructures through electric field and strain SO COMPUTATIONAL MATERIALS SCIENCE LA English DT Article DE MoS2; Heterostructures; Electric field; Band gap ID TRANSITION-METAL DICHALCOGENIDES; MONOLAYER MOS2 AB We use density functional theory to investigate the effect of finite external electric fields along with strain on the electronic structure of MoS2 multilayers and heterostructures composed of MoS2/MoSe2/MoS2 and MoS2/WS2/MoS2. We find that the presence of an electric field decreases the values of both direct and indirect band gaps, in agreement with earlier works. However, when either compressive or tensile strain is applied to the system the strength of the coupling between the electric field and direct band gap is increased while the coupling strength between the electric field and the indirect band gap is decreased. In contrast, in the heterostructures the coupling with the direct band gap remains unchanged while the coupling with indirect band gap is decreased. Taken together, these results show rich behavior of the electric field effects in MoS2 multilayers and heterostructures. (C) 2015 Elsevier B.V. All rights reserved. C1 [Lanzillo, Nicholas A.; Nayak, Saroj K.] Rensselaer Polytech Inst, Dept Phys Appl Phys & Astron, Troy, NY 12180 USA. [Lanzillo, Nicholas A.] Rensselaer Polytech Inst, Rensselaer Exploratory Ctr Cheminformat Res, Troy, NY 12180 USA. [O'Regan, Terrance P.] US Army, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20723 USA. [Nayak, Saroj K.] Indian Inst Technol, Sch Basic Sci, Bhubaneswar 751007, Orissa, India. RP Lanzillo, NA (reprint author), Rensselaer Polytech Inst, Rensselaer Exploratory Ctr Cheminformat Res, 110 8th St, Troy, NY 12180 USA. FU Army Research Lab Multiscale Multidisciplinary Modeling of Electronic Materials (MSME) Collaborative Research Alliance (CRA); Indo-US Forum on Science and Technology; Centre of Novel Energy Materials (CENEMA) - Ministry of Human Resource Development (MHRD), India FX Future work will investigate the effect of applied electric fields on thicker layers of MoS2 as well as other transition metal dichalcogenide systems using GW quasiparticle-based approaches. This work used computational resources provided by the Computational Center for Nanotechnology Innovations (CCNI) at Rensselaer Polytechnic Institute. The authors acknowledge support by the Army Research Lab Multiscale Multidisciplinary Modeling of Electronic Materials (MSME) Collaborative Research Alliance (CRA) and the Indo-US Forum on Science and Technology. The authors also acknowledge support from the Centre of Novel Energy Materials (CENEMA) funded by the Ministry of Human Resource Development (MHRD), India. NR 43 TC 1 Z9 1 U1 16 U2 92 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0927-0256 EI 1879-0801 J9 COMP MATER SCI JI Comput. Mater. Sci. PD FEB PY 2016 VL 112 BP 377 EP 382 DI 10.1016/j.commatsci.2015.11.007 PN A PG 6 WC Materials Science, Multidisciplinary SC Materials Science GA CX9VE UT WOS:000366053000048 ER PT J AU Files, BT Marathe, AR AF Files, Benjamin T. Marathe, Amar R. TI A regression method for estimating performance in a rapid serial visual presentation target detection task SO JOURNAL OF NEUROSCIENCE METHODS LA English DT Article DE RSVP; Hit rate; False alarm rate; Response time; Simulation ID COUPLED COMPUTER VISION; ATTENTIONAL BLINK; IDENTIFICATION; CLASSIFICATION; RECOGNITION; PICTURES AB Background: Estimating target detection performance in the rapid serial visual presentation (RSVP) target detection paradigm can be challenging when the inter-stimulus interval is small relative to the variability in human response time. The challenge arises because assigning a particular response to the correct image cannot be done with certainty. Existing solutions to this challenge establish a heuristic for assigning responses to images and thereby determining which responses are hits and which are false alarms. New method: We developed a regression-based method for estimating hit rate and false alarm rate that corrects for expected errors in a likelihood-based assignment of responses to stimuli. Results: Simulations show that this regression method results in an unbiased and accurate estimate of target detection performance. Comparison with existing methods: The regression method had lower estimation error compared to three existing methods, and in contrast to the existing methods, the errors made by the regression method do not depend strongly on the true values of hit rate and false alarm rate. The most commonly used existing method performed well when simulated performance was nearly perfect, but not when behavioral error rates increased. Conclusions: Based on its better estimation of hit rate and false alarm rate, the regression method proposed here would seem the best choice when estimating the hit rate and false alarm rate is the primary interest. (C) 2015 The Authors. Published by Elsevier B.V. C1 [Files, Benjamin T.; Marathe, Amar R.] Army Res Lab, Human Res & Engn Directorate, 459 Mulberry Point Rd, Aberdeen Proving Ground, MD 21005 USA. RP Files, BT (reprint author), Army Res Lab, Human Res & Engn Directorate, 459 Mulberry Point Rd, Aberdeen Proving Ground, MD 21005 USA. EM benjamin.files.ctr@mail.mil FU U.S. Army Research Laboratory under a Director's Strategic Research Initiative entitled Heterogeneous Systems for Information Variable Environments (HIVE) FX This project was supported by The U.S. Army Research Laboratory under a Director's Strategic Research Initiative entitled Heterogeneous Systems for Information Variable Environments (HIVE)and an appointment to the U.S. Army Research Laboratory Postdoctoral Fellowship program administered by the Oak Ridge Associated Universities through a cooperative agreement with the U.S. Army Research Laboratory. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 26 TC 0 Z9 0 U1 2 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-0270 EI 1872-678X J9 J NEUROSCI METH JI J. Neurosci. Methods PD JAN 30 PY 2016 VL 258 BP 114 EP 123 DI 10.1016/j.jneumeth.2015.11.003 PG 10 WC Biochemical Research Methods; Neurosciences SC Biochemistry & Molecular Biology; Neurosciences & Neurology GA DC4OB UT WOS:000369199100012 PM 26561772 ER PT J AU Perkins, MW Wong, B Tressler, J Coggins, A Rodriguez, A Devorak, J Sciuto, AM AF Perkins, Michael W. Wong, Benjamin Tressler, Justin Coggins, Andrew Rodriguez, Ashley Devorak, Jennifer Sciuto, Alfred M. TI Assessment of inhaled acute ammonia-induced lung injury in rats SO INHALATION TOXICOLOGY LA English DT Article DE lung injury; respiratory toxicology; toxic industrial chemical; inhalation exposure; Ammonia; pulmonary edema ID ACUTE INHALATION TOXICITY; BRONCHOALVEOLAR LAVAGE FLUID; EXPOSURE; NEUROTOXICITY; PHOSGENE; THERAPY; MODEL; ANIMALS; DISEASE; SOMAN AB This study examined acute toxicity and lung injury following inhalation exposure to ammonia. Male Sprague-Dawley rats (300-350 g) were exposed to 9000, 20 000, 23 000, 26 000, 30 000 or 35 000 ppm of ammonia for 20 min in a custom head-out exposure system. The exposure atmosphere, which attained steady state within 3 min for all ammonia concentrations, was monitored and verified using a Fourier transform infrared spectroscopy (FTIR) gas analyzer. Animals exposed to ammonia resulted in dose-dependent increases in observed signs of intoxication, including increased chewing and licking, ocular irritation, salivation, lacrimation, oronasal secretion and labored breathing. The LCt(50) of ammonia within this head-out inhalation exposure model was determined by probit analysis to be 23 672 ppm (16 489 mg/m(3)) for the 20 min exposure in male rats. Exposure to 20 000 or 23 000 ppm of ammonia resulted in significant body weight loss 24-h post-exposure. Lung edema increased in all ammonia-exposed animal groups and was significant following exposure to 9000 ppm. Bronchoalveolar fluid (BALF) protein concentrations significantly increased following exposure to 20 000 or 23 000 ppm of ammonia in comparison to controls. BAL cell (BALC) death and total cell counts increased in animals exposed to 20 000 or 23 000 ppm of ammonia in comparison to controls. Differential cell counts of white blood cells, neutrophils and platelets from blood and BALF were significantly increased following exposure to 23 000 ppm of ammonia. The following studies describe the validation of a head-out inhalation exposure model for the determination of acute ammonia-induced toxicity; this model will be used for the development and evaluation of potential therapies that provide protection against respiratory and systemic toxicological effects. C1 [Perkins, Michael W.; Wong, Benjamin; Tressler, Justin; Coggins, Andrew; Rodriguez, Ashley; Devorak, Jennifer; Sciuto, Alfred M.] US Army Med Res Inst Chem Def, Analyt Toxicol Div, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. RP Perkins, MW (reprint author), US Army Med Res Inst Chem Def, Analyt Toxicol Div, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM michael.w.perkins1.civ@mail.mil FU National Institute of Health (NIH) Countermeasures Against Chemical Threats (CounterACT) program [IAA: AOD14021]; Oak Ridge Associated Universities; Geneva Foundation FX Special thanks to the National Institute of Health (NIH) Countermeasures Against Chemical Threats (CounterACT) program for support (IAA: AOD14021). AR is supported by the Oak Ridge Associated Universities. AC is supported by the Geneva Foundation. The experimental protocol was approved by the Animal Care and Use Committee at the United States Army Medical Research Institute of Chemical Defense and all procedures were conducted in accordance with the principles stated in the Guide for the Care and Use of Laboratory Animals and the Animal Welfare Act of 1966 (P.L. 89-544), as amended. The views expressed in this article are those of the author(s) and do not reflect the official policy of the Department of Army, Department of Defense, or the U.S. Government. NR 41 TC 1 Z9 1 U1 2 U2 7 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0895-8378 EI 1091-7691 J9 INHAL TOXICOL JI Inhal. Toxicol. PD JAN 28 PY 2016 VL 28 IS 2 BP 71 EP 79 DI 10.3109/08958378.2015.1136715 PG 9 WC Toxicology SC Toxicology GA DF8GN UT WOS:000371595600003 PM 26821737 ER PT J AU Mackenchery, K Valisetty, RR Namburu, RR Stukowski, A Rajendran, AM Dongare, AM AF Mackenchery, Karoon Valisetty, Ramakrishna R. Namburu, Raju R. Stukowski, Alexander Rajendran, Arunachalam M. Dongare, Avinash M. TI Dislocation evolution and peak spall strengths in single crystal and nanocrystalline Cu SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID VOID GROWTH; DUCTILE FRACTURE; MAXIMUM STRENGTH; DYNAMIC FAILURE; STRAIN-RATE; COPPER; NUCLEATION; BEHAVIOR; METALS; SIMULATION AB The dynamic evolution and interaction of defects under the conditions of shock loading in single crystal and nanocrystalline Cu are investigated using a series of large-scale molecular dynamics simulations for an impact velocity of 1 km/s. Four stages of defect evolution are identified during shock simulations that result in deformation and failure. These stages correspond to: the initial shock compression (I); the propagation of the compression wave (II); the propagation and interaction of the reflected tensile wave (III); and the nucleation, growth, and coalescence of voids (IV). The effect of the microstructure on the evolution of defect densities during these four stages is characterized and quantified for single crystal Cu as well as nanocrystalline Cu with an average grain size of 6 nm, 10 nm, 13 nm, 16 nm, 20 nm, and 30 nm. The evolution of twin densities during the shock propagation is observed to vary with the grain size of the system and affects the spall strength of the metal. The grain sizes of 6 nm and 16 nm are observed to have peak values for the twin densities and a spall strength that is comparable with the single crystal Cu. (C) 2016 AIP Publishing LLC. C1 [Mackenchery, Karoon; Dongare, Avinash M.] Univ Connecticut, Dept Mat Sci & Engn, Storrs, CT 06269 USA. [Mackenchery, Karoon; Dongare, Avinash M.] Univ Connecticut, Inst Mat Sci, Storrs, CT 06269 USA. [Valisetty, Ramakrishna R.; Namburu, Raju R.] US Army Res Lab, Computat & Informat Sci Directorate, Aberdeen Proving Ground, MD 21005 USA. [Stukowski, Alexander] Tech Univ Darmstadt, Inst Mat Sci, D-64287 Darmstadt, Germany. [Rajendran, Arunachalam M.] Univ Mississippi, Dept Mech Engn, 201-B Carrier Hall, University, MS 38677 USA. RP Dongare, AM (reprint author), Univ Connecticut, Dept Mat Sci & Engn, Storrs, CT 06269 USA.; Dongare, AM (reprint author), Univ Connecticut, Inst Mat Sci, Storrs, CT 06269 USA. EM dongare@uconn.edu OI Stukowski, Alexander/0000-0001-6750-3401; Dongare, Avinash/0000-0003-3189-3588 FU NSF CMMI [1454547]; Student Research Participation Program at the U.S. Army Research Laboratory (USARL) FX This work acknowledges the support from NSF CMMI under Grant No. 1454547 and K.M. acknowledges the support in part from the Student Research Participation Program at the U.S. Army Research Laboratory (USARL) administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USARL. Computational support through the Department of Defense (DOD), High Performance Computing Modernization Program (HPCMP), and the Booth Engineering Center for Advanced Technology (BECAT) is also acknowledged. NR 51 TC 4 Z9 4 U1 7 U2 22 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD JAN 28 PY 2016 VL 119 IS 4 AR 044301 DI 10.1063/1.4939867 PG 11 WC Physics, Applied SC Physics GA DD4ME UT WOS:000369896300015 ER PT J AU Wang, RL Biales, AD Garcia-Reyero, N Perkins, EJ Villeneuve, DL Ankley, GT Bencic, DC AF Wang, Rong-Lin Biales, Adam D. Garcia-Reyero, Natalia Perkins, Edward J. Villeneuve, Daniel L. Ankley, Gerald T. Bencic, David C. TI Fish connectivity mapping: linking chemical stressors by their mechanisms of action-driven transcriptomic profiles SO BMC GENOMICS LA English DT Article DE Fish; Gene expression profiles; Connectivity mapping ID MINNOWS PIMEPHALES-PROMELAS; GENE-EXPRESSION SIGNATURES; BISPHENOL-A; ANDROGEN RECEPTOR; RISK-ASSESSMENT; HYDROCARBON RECEPTOR; MOLECULAR TARGET; ECOLOGICAL RISK; FATHEAD MINNOW; ZEBRAFISH AB Background: A very large and rapidly growing collection of transcriptomic profiles in public repositories is potentially of great value to developing data-driven bioinformatics applications for toxicology/ecotoxicology. Modeled on human connectivity mapping (Cmap) in biomedical research, this study was undertaken to investigate the utility of an analogous Cmap approach in ecotoxicology. Over 3500 zebrafish (Danio rerio) and fathead minnow (Pimephales promelas) transcriptomic profiles, each associated with one of several dozen chemical treatment conditions, were compiled into three distinct collections of rank-ordered gene lists (ROGLs) by species and microarray platforms. Individual query signatures, each consisting of multiple gene probes differentially expressed in a chemical condition, were used to interrogate the reference ROGLs. Results: Informative connections were established at high success rates within species when, as defined by their mechanisms of action (MOAs), both query signatures and ROGLs were associated with the same or similar chemicals. Thus, a simple query signature functioned effectively as an exposure biomarker without need for a time-consuming process of development and validation. More importantly, a large reference database of ROGLs also enabled a query signature to cross-interrogate other chemical conditions with overlapping MOAs, leading to novel groupings and subgroupings of seemingly unrelated chemicals at a finer resolution. This approach confirmed the identities of several estrogenic chemicals, as well as a polycyclic aromatic hydrocarbon and a neuro-toxin, in the largely uncharacterized water samples near several waste water treatment plants, and thus demonstrates its future potential utility in real world applications. Conclusions: The power of Cmap should grow as chemical coverages of ROGLs increase, making it a framework easily scalable in the future. The feasibility of toxicity extrapolation across fish species using Cmap needs more study, however, as more gene expression profiles linked to chemical conditions common to multiple fish species are needed. C1 [Wang, Rong-Lin; Biales, Adam D.; Bencic, David C.] US EPA, Exposure Methods & Measurements Div, Natl Exposure Res Lab, 26 W Martin Luther King Dr,MS 587, Cincinnati, OH 45268 USA. [Garcia-Reyero, Natalia; Perkins, Edward J.] US Army Corps Engineers, US Army Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. [Villeneuve, Daniel L.; Ankley, Gerald T.] US EPA, Midcontinent Ecol Div, Natl Hlth & Environm Effects Res Lab, 6201 Congdon Blvd, Duluth, MN 55804 USA. RP Wang, RL (reprint author), US EPA, Exposure Methods & Measurements Div, Natl Exposure Res Lab, 26 W Martin Luther King Dr,MS 587, Cincinnati, OH 45268 USA. EM Wang.Rong-Lin@epa.gov FU US Environmental Protection Agency (USEPA); U.S. Army Environmental Quality and Installations program; U.S. Army [BAA 11-4838] FX Funding for zebrafish exposures and microarray analysis was provided by US Environmental Protection Agency (USEPA). The U.S. Army Environmental Quality and Installations program and U.S. Army (grant BAA 11-4838) provided funding for fathead minnow microarrays analysis. The funders had no role in study design, data collection and analysis, or preparation of the manuscript. We thank Lynn Escalon and Xin Guan in the Environmental Laboratory, US Army Engineer Research and Development Center for microarray data generation. The internal technical review was conducted by Mark Nelms at the National Health and Environmental Effects Research Laboratory, USEPA. The views expressed in this article are those of the authors and do not necessarily represent the views or policies of the USEPA. The manuscript has been approved for publication by USEPA and US Army Corps Chief of Engineers. NR 62 TC 0 Z9 0 U1 5 U2 18 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2164 J9 BMC GENOMICS JI BMC Genomics PD JAN 28 PY 2016 VL 17 AR 84 DI 10.1186/s12864-016-2406-y PG 20 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA DC0GH UT WOS:000368894700001 PM 26822894 ER PT J AU Zhang, ZJ Nguyen, HTH Miller, SA Ploskonka, AM DeCoste, JB Cohen, SM AF Zhang, Zhenjie Ha Thi Hoang Nguyen Miller, Stephen A. Ploskonka, Ann M. DeCoste, Jared B. Cohen, Seth M. TI Polymer-Metal-Organic Frameworks (polyMOFs) as Water Tolerant Materials for Selective Carbon Dioxide Separations SO JOURNAL OF THE AMERICAN CHEMICAL SOCIETY LA English DT Article ID SUPRAMOLECULAR POLYMERS; BLOCK-COPOLYMERS; ADSORPTION; GEL; METALLOPOLYMERS; STABILITY; CAPTURE AB Recently, polymer-metal-organic frameworks (polyMOFs) were reported as a new class of hybrid porous materials that combine advantages of both organic polymers and crystalline MOFs. Herein, we report a bridging coligand strategy to prepare new types of polyMOFs, demonstrating that polyMOFs are compatible with additional MOF architectures besides that of the earlier reported IRMOF-1 type polyMOF. Gas sorption studies revealed that these polyMOF materials exhibited relatively high CO2 sorption but very low N-2 sorption, making them promising materials for CO2/N-2 separations. Moreover, these polyMOFs demonstrated exceptional water stability attributed to the hydrophobicity of polymer ligands as well as the cross-linking of the polymer chains within the MOF. C1 [Zhang, Zhenjie; Cohen, Seth M.] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA. [Ha Thi Hoang Nguyen] Univ Florida, Dept Chem, George & Josephine Butler Lab Polymer Res, Gainesville, FL 32611 USA. [Ploskonka, Ann M.; DeCoste, Jared B.] Leidos Inc, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. [DeCoste, Jared B.] US Army Res Dev & Engn Command, Edgewood Chem Biol Ctr, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. RP Cohen, SM (reprint author), Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA. EM scohen@ucsd.edu OI Cohen, Seth/0000-0002-5233-2280 FU Department of Energy, Office of Basic Energy Sciences, Division of Materials Science and Engineering [DE-FG02-08ER46519]; National Science Foundation [CHE-1305794]; Joint Science and Technology Office for Chemical Biological Defense (JSTO-CBD) [BA07PRO104] FX This work was supported by a grant from the Department of Energy, Office of Basic Energy Sciences, Division of Materials Science and Engineering under Award No. DE-FG02-08ER46519 (S.M.C.) and the National Science Foundation under Award No. CHE-1305794 (S.A.M.). We also acknowledge the Joint Science and Technology Office for Chemical Biological Defense (JSTO-CBD) for funding under Project Number BA07PRO104. NR 34 TC 22 Z9 22 U1 75 U2 255 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0002-7863 J9 J AM CHEM SOC JI J. Am. Chem. Soc. PD JAN 27 PY 2016 VL 138 IS 3 BP 920 EP 925 DI 10.1021/jacs.5b11034 PG 6 WC Chemistry, Multidisciplinary SC Chemistry GA DC2KA UT WOS:000369044400037 PM 26709448 ER PT J AU Rodriguez, RI Jordon, JB Allison, PG Rushing, T Garcia, L AF Rodriguez, R. I. Jordon, J. B. Allison, P. G. Rushing, T. Garcia, L. TI Low-cycle fatigue of dissimilar friction stir welded aluminum alloys SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE Welding; Aluminum alloys; Fatigue; Fracture ID TOOL ROTATIONAL SPEED; MECHANICAL-PROPERTIES; MAGNESIUM ALLOY; PIN PROFILE; AL-ALLOYS; TENSILE-STRENGTH; 6061-T6 ALUMINUM; CAST A356-T6; MG ALLOY; MICROSTRUCTURE AB In this work, experiments were conducted to quantify structure-property relations of low-cycle fatigue behavior of dissimilar friction stir welding (FSW) of AA6061-to-AA7050 high strength aluminum alloys. In addition, a microstructure-sensitive fatigue model is employed to further elucidate cause-effect relationships. Experimental strain-controlled fatigue testing revealed an increase in the cyclic strain hardening and the number-of cycles to failure as the tool rotational speed was increased. At higher applied strain amplitudes (> 0.3%), the corresponding stress amplitude increased and the plastic strain amplitude decreased, as the number of cycles increased. However, at 0.2% strain amplitude, the plastic strain decreased until it was almost negligible. Inspection of the hysteresis loops demonstrated that at low strain amplitudes, there was an initial stage of strain hardening that increased until it reached a maximum strain hardening level, afterwards a nearly perfect elastic behavior was observed. Under fully-reversed fatigue loading, all samples failed at the region between the heat-affected and thermomechnically-affected zones. Inspection of the fractured surfaces under scanning electron microscopy revealed that the cracks initiated at either the crown or the root surface of the weld, and from secondary intermetallic particles located near the free surface of the weld. Lastly, a microstructure-sensitive multistage fatigue model was employed to correlate the fatigue life of the dissimilar FSW of AA6061-to-AA7050 considering microstructural features such as grain size, intermetallic particles and mechanical properties. (C) 2015 Elsevier B.V. All rights reserved. C1 [Rodriguez, R. I.; Jordon, J. B.; Allison, P. G.] Univ Alabama, Dept Mech Engn, Tuscaloosa, AL 35487 USA. [Rushing, T.; Garcia, L.] Army Corps Engineers, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Jordon, JB (reprint author), Univ Alabama, Dept Mech Engn, Tuscaloosa, AL 35487 USA. EM bjordon@eng.ua.edu FU U.S. Army Research Office Scientific Services Program [W911NF-11-D-0001]; University of Alabama; GAANN Fellowship Program FX The authors would like to acknowledge Mr. Robert McCullough, Dr. Mark Barkey, and Mr. Jeb Tingle for the their helpful discussions. In addition, the authors would like to thank Mr. Cody Rickard for his help in preparing the samples for mechanical testing and metallurgical analysis. The authors would also like to thank The Edison Welding Instituted (EWI) for FSW the joints. A portion of the work was performed under the auspices of the U.S. Army Research Office Scientific Services Program administered by Battelle Memorial Institute, Contract No. W911NF-11-D-0001. Permission to publish was granted by Director, Geotechnical and Structures Laboratory. Additionally, this work utilized resources owned and maintained by the Central Analytical Facility, which is supported by The University of Alabama. Lastly, the authors would like to acknowledge the GAANN Fellowship Program for partial support of this project. NR 57 TC 2 Z9 2 U1 7 U2 24 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 EI 1873-4936 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD JAN 27 PY 2016 VL 654 BP 236 EP 248 DI 10.1016/j.msea.2015.11.075 PG 13 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA DD7NJ UT WOS:000370111100027 ER PT J AU Liu, B Xu, W Yan, PF Sun, XL Bowden, ME Read, J Qian, JF Mei, DH Wang, CM Zhang, JG AF Liu, Bin Xu, Wu Yan, Pengfei Sun, Xiuliang Bowden, Mark E. Read, Jeffrey Qian, Jiangfeng Mei, Donghai Wang, Chong-Min Zhang, Ji-Guang TI Enhanced Cycling Stability of Rechargeable Li-O-2 Batteries Using High-Concentration Electrolytes SO ADVANCED FUNCTIONAL MATERIALS LA English DT Article DE air electrodes; high-concentration electrolytes; Li-O-2 batteries; lithium metal; stability ID LITHIUM-OXYGEN BATTERIES; ETHER-BASED ELECTROLYTES; CARBONATE ELECTROLYTES; BIFUNCTIONAL CATALYST; ION BATTERIES; AIR BATTERY; REVERSIBILITY; LIMITATIONS; SOLVATION; DENSITY AB The stability of electrolytes against highly reactive, reduced oxygen species is crucial for the development of rechargeable Li-O-2 batteries. In this work, the effect of lithium salt concentration in 1,2-dimethoxyethane (DME)-based electrolytes on the cycling stability of Li-O-2 batteries is investigated systematically. Cells with highly concentrated electrolyte demonstrate greatly enhanced cycling stability under both full discharge/charge (2.0-4.5 V vs Li/Li+) and the capacity-limited (at 1000 mAh g(-1)) conditions. These cells also exhibit much less reaction residue on the charged air-electrode surface and much less corrosion of the Li-metal anode. Density functional theory calculations are used to calculate molecular orbital energies of the electrolyte components and Gibbs activation energy barriers for the superoxide radical anion in the DME solvent and Li+-(DME) (n) solvates. In a highly concentrated electrolyte, all DME molecules are coordinated with salt cations, and the C-H bond scission of the DME molecule becomes more difficult. Therefore, the decomposition of the highly concentrated electrolyte can be mitigated, and both air cathodes and Li-metal anodes exhibit much better reversibility, resulting in improved cyclability of Li-O-2 batteries. C1 [Liu, Bin; Xu, Wu; Qian, Jiangfeng; Zhang, Ji-Guang] Pacific NW Natl Lab, Energy & Environm Directorate, Richland, WA 99354 USA. [Yan, Pengfei; Bowden, Mark E.; Wang, Chong-Min] Pacific NW Natl Lab, Environm Mol Sci Lab, Richland, WA 99354 USA. [Sun, Xiuliang; Mei, Donghai] Pacific NW Natl Lab, Fundamental & Computat Sci Directorate, Richland, WA 99354 USA. [Sun, Xiuliang] Beijing Univ Chem Technol, Dept Chem Engn, Beijing 100029, Peoples R China. [Read, Jeffrey] US Army, Res Lab, Sensors & Elect Devices Directorate, Power & Energy Div, Adelphi, MD 20783 USA. RP Xu, W; Zhang, JG (reprint author), Pacific NW Natl Lab, Energy & Environm Directorate, Richland, WA 99354 USA. EM wu.xu@pnnl.gov; jiguang.zhang@pnnl.gov RI yan, pengfei/E-4784-2016; Mei, Donghai/A-2115-2012; Mei, Donghai/D-3251-2011; Liu, Bin/J-6942-2012 OI yan, pengfei/0000-0001-6387-7502; Mei, Donghai/0000-0002-0286-4182; Liu, Bin/0000-0001-8797-3275 FU Office of Vehicle Technologies of the US Department of Energy (DOE) [DEAC02-05CH11231, DEAC02-98CH10886]; DOE's Office of Biological and Environmental Research (BER); DOE [DE-AC05-76RLO1830] FX This work was supported by the Assistant Secretary for Energy Efficiency and Renewable Energy, Office of Vehicle Technologies of the US Department of Energy (DOE) under Contract no. DEAC02-05CH11231 for PNNL and under DEAC02-98CH10886 under the Advanced Battery Materials Research (BMR) program. The microscopic and spectroscopic characterizations were conducted in the William R. Wiley Environmental Molecular Sciences Laboratory (EMSL)-a national scientific user facility located at PNNL which is sponsored by the DOE's Office of Biological and Environmental Research (BER). PNNL is operated by Battelle for the DOE under Contract DE-AC05-76RLO1830. NR 40 TC 7 Z9 7 U1 22 U2 87 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 1616-301X EI 1616-3028 J9 ADV FUNCT MATER JI Adv. Funct. Mater. PD JAN 26 PY 2016 VL 26 IS 4 BP 605 EP 613 DI 10.1002/adfm.201503697 PG 9 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA DC0DA UT WOS:000368886000015 ER PT J AU Hauser, JL Tran, DT Conley, ET Saunders, JM Bustillo, KC Oliver, SRJ AF Hauser, Jesse L. Tran, Dat T. Conley, Edward T. Saunders, John M. Bustillo, Karen C. Oliver, Scott R. J. TI Plasma Treatment of Silver Impregnated Mesoporous Aluminosilicate Nanoparticles for Adsorptive Desulfurization SO CHEMISTRY OF MATERIALS LA English DT Article ID DEEP DESULFURIZATION; SELECTIVE ADSORPTION; JET FUEL; TRANSPORTATION FUELS; PI-COMPLEXATION; ACTIVE-SITES; LIQUID FUELS; DIESEL FUEL; ADSORBENTS; OXIDATION AB We report a regenerable adsorbent for the removal of refractory organosulfur compounds from fossil fuels. The material is composed of well dispersed silver nanoparticles confined within the mesochannels of aluminum doped MCM-41 nanoparticles. With an average initial desulfurization capacity of 15 mg S.g(-1), 79% desulfurization capacity is retained after six cycles for the removal of dibenzothiophene from n-decane. The addition of intraframework aluminum to form a mesoporous aluminosilicate nanoparticle (MASN) aids in the retention and dispersion of silver ions within the mesochannels (Ag-MASN). The nanoparticles are subsequently reduced by glow discharge plasma treatment in argon (PT-Ag-MASN). The size dispersion, surface area, and structural integrity were characterized by scanning electron microscopy, annular dark-field scanning transmission electron microscopy (ADF-STEM), nitrogen adsorption analysis (BET), and powder X-ray diffraction. Silver nanoparticle formation within the mesochannels of MASN was confirmed by ADF-STEM and diffuse reflectance UV-vis spectroscopy. Model fuel testing revealed that PT Ag-MASN had the highest regeneration capacity after six cycles compared to non-plasma-treated (Ag-MASN) and aluminum-free materials (Ag-MSN and PT-Ag-MSN). Initial testing of the military jet fuel JP-8 also shows a high desulfurization capacity of 41 mg S.g(-1). C1 [Hauser, Jesse L.; Conley, Edward T.; Saunders, John M.; Oliver, Scott R. J.] Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA. [Tran, Dat T.] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Bustillo, Karen C.] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Natl Ctr Electron Microscopy, Mol Foundry, Berkeley, CA 94720 USA. RP Oliver, SRJ (reprint author), Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA.; Tran, DT (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM dat.t.tran4.civ@mail.mil; soliver@ucsc.edu FU Office of Science, Office of Basic Energy Sciences, of the U.S. Department of Energy [DE-AC02-05CH11231] FX We acknowledge the assistance of Rob Franks with inductively coupled plasma-optical emission spectroscopy (ICP-OES) in the Institute of Marine Sciences at UC Santa Cruz. We also acknowledge Dr. Tom Yuzvinsky and the W.M. Keck Center for Nanoscale Optofluidics at UC Santa Cruz for the use and assistance in image acquisition on the FEI Quanta 3D Dualbeam microscope. We acknowledge the assistance of the National Center for Electron Microscopy, Molecular Foundry, Lawrence Berkeley National Lab, for use and image acquisition on the FEI Titan TEM. Work at the Molecular Foundry was supported by the Office of Science, Office of Basic Energy Sciences, of the U.S. Department of Energy under Contract No. DE-AC02-05CH11231. NR 26 TC 3 Z9 3 U1 15 U2 46 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0897-4756 EI 1520-5002 J9 CHEM MATER JI Chem. Mat. PD JAN 26 PY 2016 VL 28 IS 2 BP 474 EP 479 DI 10.1021/acs.chemmater.5b03018 PG 6 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA DC1AT UT WOS:000368949900011 ER PT J AU Duarte, A Hatfield, JS Swannack, TM Forstner, MRJ Green, MC Weckerly, FW AF Duarte, Adam Hatfield, Jeff S. Swannack, Todd M. Forstner, Michael R. J. Green, M. Clay Weckerly, Floyd W. TI Simulating range-wide population and breeding habitat dynamics for an endangered woodland warbler in the face of uncertainty SO ECOLOGICAL MODELLING LA English DT Article DE Extinction risk; Habitat conservation; Habitat dynamics; Multistate model; Population dynamics; Setophaga chrysoparia ID GOLDEN-CHEEKED WARBLER; LAND-COVER DATABASE; ASHE JUNIPER; TRANSITION-PROBABILITIES; CONSERVATION; COMMUNITIES; LANDSCAPES; SUCCESSION; THRESHOLD; RECOVERY AB Population viability analyses provide a quantitative approach that seeks to predict the possible future status of a species of interest under different scenarios and, therefore, can be important components of large-scale species' conservation programs. We created a model and simulated range-wide population and breeding habitat dynamics for an endangered woodland warbler, the golden-cheeked warbler (Setophaga chrysoparia). Habitat-transition probabilities were estimated across the warbler's breeding range by combining National Land Cover Database imagery with multistate modeling. Using these estimates, along with recently published demographic estimates, we examined if the species can remain viable into the future given the current conditions. Lastly, we evaluated if protecting a greater amount of habitat would increase the number of warblers that can be supported in the future by systematically increasing the amount of protected habitat and comparing the estimated terminal carrying capacity at the end of 50 years of simulated habitat change. The estimated habitat-transition probabilities supported the hypothesis that habitat transitions are unidirectional, whereby habitat is more likely to diminish than regenerate. The model results indicated population viability could be achieved under current conditions, depending on dispersal. However, there is considerable uncertainty associated with the population projections due to parametric uncertainty. Model results suggested that increasing the amount of protected lands would have a substantial impact on terminal carrying capacities at the end of a 50-year simulation. Notably, this study identifies the need for collecting the data required to estimate demographic parameters in relation to changes in habitat metrics and population density in multiple regions, and highlights the importance of establishing a common definition of what constitutes protected habitat, what management goals are suitable within those protected areas, and a standard operating procedure to identify areas of priority for habitat conservation efforts. Therefore, we suggest future efforts focus on these aspects of golden-cheeked warbler conservation and ecology. (C) 2015 Elsevier B.V. All rights reserved. C1 [Duarte, Adam; Swannack, Todd M.; Forstner, Michael R. J.; Green, M. Clay; Weckerly, Floyd W.] Texas State Univ, Dept Biol, San Marcos, TX USA. [Hatfield, Jeff S.] US Geol Survey, Patuxent Wildlife Res Ctr, Laurel, MD USA. [Swannack, Todd M.] US Army Engineer Res & Dev Ctr, Vicksburg, MS USA. RP Duarte, A (reprint author), Oregon State Univ, Dept Fisheries & Wildlife, Oregon Cooperat Fish & Wildlife Res Unit, Corvallis, OR 97331 USA. EM adam.duarte@oregonstate.edu FU U.S. Geological Survey Science Support Partnership Program through U.S. Fish and Wildlife Service, Texas State University; Houston Safari Club; National Wild Turkey Federation FX We thank J. D. Nichols, J. R. Sauer, and an anonymous reviewer for reviewing an earlier draft of the manuscript. J. L. R. Jensen allowed us to use her computers to run a portion of the simulations, and we are grateful. This project was funded by the U.S. Geological Survey Science Support Partnership Program through the U.S. Fish and Wildlife Service, Texas State University, the Houston Safari Club, and the National Wild Turkey Federation. Recovery-unit boundary shapefiles were provided by the Austin Ecological Services Office of the USFWS. Conservation and recreation-land shapefiles were provided by Texas Parks & Wildlife Department Land and Water Resources Conservation and Recreation Plan Statewide Inventory-2012 and military-land shapefiles were downloaded from the Defense Installation Spatial Data Infrastructure website (http://www.acq.osd.mil/ie/). Any use of trade, product, or firm names is for descriptive purposes only and does not imply endorsement by the U.S. Government. NR 43 TC 0 Z9 0 U1 4 U2 11 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3800 EI 1872-7026 J9 ECOL MODEL JI Ecol. Model. PD JAN 24 PY 2016 VL 320 BP 52 EP 61 DI 10.1016/j.ecolmodel.2015.09.018 PG 10 WC Ecology SC Environmental Sciences & Ecology GA DB2BM UT WOS:000368313300005 ER PT J AU Matheny, RW Geddis, AV Abdalla, MN Leandry, LA AF Matheny, Ronald W., Jr. Geddis, Alyssa V. Abdalla, Mary N. Leandry, Luis A. TI Phosphatidylinositol 3-kinase p110 alpha mediates phosphorylation of AMP-activated protein kinase in myoblasts SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS LA English DT Article DE Phosphatidylinositol 3-kinase (PI3K); AMP-Activated protein kinase (AMPK); p110 alpha; Akt; Myoblast ID SKELETAL-MUSCLE; EXERCISE INTENSITY; AKT ACTIVATION; INSULIN; P110-BETA; CELLS; SER(485/491); DOWNSTREAM; AGENTS; HEART AB AMP-activated protein kinase (AMPK) is a serine/threonine kinase that functions as a sensor of intracellular energy. Activation of AMPK is associated with increased phosphorylation of the a-subunit at threonine 172 (T172) and decreased phosphorylation at serine 485 in AMPK alpha 1 and serine 491 in AMPK alpha 2 (S485/491). One potential mediator of AMPK phosphorylation is phosphatidylinositol 3-kinase (PI3K); however, the mechanism and the identities of the specific PI3K isoforms that regulate AMPK activation are not known. To determine whether PI3K p110 alpha regulated AMPK activation in muscle cells, C2C12 myoblasts were subjected to pharmacological inhibition of p110 alpha, siRNA directed against p110 alpha, or overexpression of constitutively-active or dominant negative p110 alpha. Chemical inhibition, siRNA, and expression of dominant-negative p110 alpha were all associated with increased AMPK T172 phosphorylation, whereas expression of constitutively-active p110 alpha reduced T172 phosphorylation. Conversely, pharmacological inhibition of p110 alpha reduced AMPK S485/491 phosphorylation, while constitutively-active p110 alpha increased AMPK S485/491 phosphorylation. This p110 alpha-mediated increase in AMPK S485/491 phosphorylation was eliminated in the presence of the Akt inhibitor MK2206, suggesting that p110 alpha-mediated phosphorylation of AMPK alpha at S485/491 is Akt-dependent. In response to oligomycin or serum starvation, AMPK T172 phosphorylation was elevated in p11 alpha-deficient myoblasts compared to control myoblasts. Overall, our findings identify PI3K p110a as a mediator of AMPK phosphorylation in myoblasts. (C) Published by Elsevier Inc. C1 [Matheny, Ronald W., Jr.; Geddis, Alyssa V.; Abdalla, Mary N.; Leandry, Luis A.] US Army Res Inst Environm Med, Mil Performance Div, 15 Kansas St,Bldg 42, Natick, MA 01760 USA. [Abdalla, Mary N.] Univ Massachusetts, Sch Med, Dept Mol Cell & Canc Biol, 364 Plantat St, Worcester, MA 01605 USA. RP Matheny, RW (reprint author), US Army Res Inst Environm Med, Mil Performance Div, 15 Kansas St,Bldg 42, Natick, MA 01760 USA. EM ronald.w.matheny.civ@mail.mil FU U.S. Department of Energy; U.S. Army Medical Research and Materiel Command FX A.V.G. and M.N.A. were supported by appointments to the Postgraduate Research Participation Program at the U.S. Army Research Institute of Environmental Medicine administered by the Oak Ridge Institute for Science and Education through interagency agreement between the U.S. Department of Energy and U.S. Army Medical Research and Materiel Command. NR 31 TC 2 Z9 2 U1 1 U2 1 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0006-291X EI 1090-2104 J9 BIOCHEM BIOPH RES CO JI Biochem. Biophys. Res. Commun. PD JAN 22 PY 2016 VL 469 IS 4 BP 1117 EP 1122 DI 10.1016/j.bbrc.2015.12.118 PG 6 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA DC6TR UT WOS:000369353000050 PM 26742424 ER PT J AU Wright, LKM Lee, RB Vincelli, NM Whalley, CE Lumley, LA AF Wright, Linnzi K. M. Lee, Robyn B. Vincelli, Nicole M. Whalley, Christopher E. Lumley, Lucille A. TI Comparison of the lethal effects of chemical warfare nerve agents across multiple ages SO TOXICOLOGY LETTERS LA English DT Article DE Chemical warfare nerve agent; Development; Median lethal dose; Rat; Subcutaneous ID ORGANOPHOSPHORUS COMPOUNDS; SOMAN TOXICITY; EXPOSURE CONCENTRATION; ESTERASE-ACTIVITIES; GUINEA-PIGS; RATS; CARBOXYLESTERASE; PROTECTION; BRAIN; VAPOR AB Children may be inherently more vulnerable than adults to the lethal effects associated with chemical warfare nerve agent (CWNA) exposure because of their closer proximity to the ground, smaller body mass, higher respiratory rate, increased skin permeability and immature metabolic systems. Unfortunately, there have only been a handful of studies on the effects of CWNA in pediatric animal models, and more research is needed to confirm this hypothesis. Using a stagewise, adaptive dose design, we estimated the 24 h median lethal dose for subcutaneous exposure to seven CWNA in both male and female Sprague-Dawley rats at six different developmental times. Perinatal (postnatal day [PND] 7, 14 and 21) and adult (PND 70) rats were more susceptible than pubertal (PND 28 and 42) rats to the lethal effects associated with exposure to tabun, sarin, soman and cyclosarin. Age-related differences in susceptibility were not observed in rats exposed to VM, Russian VX or VX. Published by Elsevier Ireland Ltd. C1 [Wright, Linnzi K. M.; Lee, Robyn B.; Lumley, Lucille A.] US Army Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. [Vincelli, Nicole M.; Whalley, Christopher E.] Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Lumley, LA (reprint author), US Army Med Res Inst Chem Def, 2900 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM lucille.a.lange.civ@mail.mil NR 36 TC 2 Z9 3 U1 1 U2 130 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0378-4274 EI 1879-3169 J9 TOXICOL LETT JI Toxicol. Lett. PD JAN 22 PY 2016 VL 241 BP 167 EP 174 DI 10.1016/j.toxlet.2015.11.023 PG 8 WC Toxicology SC Toxicology GA DA2VA UT WOS:000367653700018 PM 26621540 ER PT J AU Sellers, MS Hurley, MM AF Sellers, Michael S. Hurley, Margaret M. TI XPairIt Docking Protocol for peptide docking and analysis SO MOLECULAR SIMULATION LA English DT Article DE peptide docking; software design; docking methodology ID MOLECULAR-DYNAMICS; DRUG DESIGN; RECEPTOR FLEXIBILITY; PROTEINS; BINDING; COMPLEXES; ALGORITHM; KNOWLEDGE; ROSETTA; NAMD AB The mechanics of peptide-protein docking has long been an area of intense interest to the computational community. Here we discuss an improved docking protocol named XPairIt which uses a multitier approach, combining the PyRosetta docking software with the NAMD molecular dynamics package through a biomolecular simulation programming interface written in Python. This protocol is designed for systems where no a priori information of ligand structure (beyond sequence) or binding location is known. It provides for efficient incorporation of both ligand and target flexibility, is HPC-ready and is easily extensible for use of custom code. We apply this protocol to a set of 11 test cases drawn from benchmarking databases and from previously published studies for direct comparison with existing protocols. Strengths, weaknesses and areas of improvement are discussed. C1 [Sellers, Michael S.; Hurley, Margaret M.] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Sellers, MS (reprint author), US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM michael.s.sellers.ctr@us.army.mil FU Defense Threat Reduction Agency Joint Science and Technology Office for Chemical and Biological Defense [BRCALL08-Per3-P-2-0028]; U.S. Army Research Laboratory FX This project received support from the Defense Threat Reduction Agency Joint Science and Technology Office for Chemical and Biological Defense [grant number BRCALL08-Per3-P-2-0028]. Research is also supported in part by appointments to the U.S. Army Research Laboratory Postdoctoral Fellowship Program administered by the Oak Ridge Associated Universities through a contract with the U.S. Army Research Laboratory. NR 42 TC 2 Z9 2 U1 2 U2 25 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0892-7022 EI 1029-0435 J9 MOL SIMULAT JI Mol. Simul. PD JAN 22 PY 2016 VL 42 IS 2 BP 149 EP 161 DI 10.1080/08927022.2015.1025267 PG 13 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA CS6LL UT WOS:000362190200007 ER PT J AU Przekwas, A Somayaji, MR Gupta, RK AF Przekwas, Andrzej Somayaji, Mahadevabharath R. Gupta, Raj K. TI Synaptic Mechanisms of Blast-Induced Brain Injury SO FRONTIERS IN NEUROLOGY LA English DT Article DE synapse; TBI; neuro-axonal; blast wave injury; mechanobiology; DAI ID CELL-ADHESION MOLECULES; IN-VITRO; SUBDURAL-HEMATOMA; AXONAL INJURY; DEFORMATION; STRESS; PLASTICITY; SYNAPSES; BIOMECHANICS; DISORDERS AB Blast wave-induced traumatic brain injury (TBI) is one of the most common injuries to military personnel. Brain tissue compression/tension due to blast-induced cranial deformations and shear waves due to head rotation may generate diffuse micro-damage to neuro-axonal structures and trigger a cascade of neurobiological events culminating in cognitive and neurodegenerative disorders. Although diffuse axonal injury is regarded as a signature wound of mild TBI (mTBI), blast loads may also cause synaptic injury wherein neuronal synapses are stretched and sheared. This synaptic injury may result in temporary disconnect of the neural circuitry and transient loss in neuronal communication. We hypothesize that mTBI symptoms such as loss of consciousness or dizziness, which start immediately after the insult, could be attributed to synaptic injury. Although empirical evidence is beginning to emerge; the detailed mechanisms underlying synaptic injury are still elusive. Coordinated in vitro-in vivo experiments and mathematical modeling studies can shed light into the synaptic injury mechanisms and their role in the potentiation of mTBI symptoms. C1 [Przekwas, Andrzej; Somayaji, Mahadevabharath R.] CFD Res Corp, Computat Med & Biol Div, Huntsville, AL USA. [Gupta, Raj K.] US Army Med Res & Mat Command, Dept Def Blast Injury Res Program Coordinating Of, Ft Detrick, MD USA. RP Przekwas, A (reprint author), CFD Res Corp, Computat Med & Biol Div, Huntsville, AL USA. EM andrzej.przekwas@cfdrc.com FU Department of Defense Congressionally Directed Medical Research Programs (CDMRP) [W81XWH-11-2-0057] FX The authors (AJP and MRS) would like to express their appreciation to the Department of Defense Congressionally Directed Medical Research Programs (CDMRP) under contract W81XWH-11-2-0057 for supporting this work. The authors acknowledge Dr. Vincent Harrand, CFDRC and Prof. Beverly Rzigalinski, Virginia Tech, for reviewing the manuscript. NR 90 TC 2 Z9 2 U1 5 U2 14 PU FRONTIERS MEDIA SA PI LAUSANNE PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLAND SN 1664-2295 J9 FRONT NEUROL JI Front. Neurol. PD JAN 21 PY 2016 VL 7 AR UNSP 2 DI 10.3389/fneur.2016.00002 PG 8 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA DE2BD UT WOS:000370430300001 PM 26834697 ER PT J AU Long, JW Wallace, JM Peterson, GW Huynh, K AF Long, Jeffrey W. Wallace, Jean M. Peterson, Gregory W. Huynh, Kim TI Manganese Oxide Nanoarchitectures as Broad-Spectrum Sorbents for Toxic Gases SO ACS APPLIED MATERIALS & INTERFACES LA English DT Article DE manganese oxide; ammonia; sulfur dioxide; hydrogen sulfide; air filtration ID SELECTIVE CATALYTIC-REDUCTION; NANOCRYSTALLINE METAL-OXIDES; SULFUR-DIOXIDE; REACTIVE ADSORPTION; SURFACE-CHEMISTRY; AQUEOUS-SOLUTIONS; HYDROGEN-SULFIDE; ETHYL SULFIDE; FT-IR; OXIDATION AB We demonstrate that sol-gel-derived manganese oxide (MnOx) nanoarchitectures exhibit broad-spectrum filtration activity for three chemically diverse toxic gases: NH3, SO2, and H2S. Manganese oxides are synthesized via the reaction of NaMnO4 and fumaric acid to form monolithic gels of disordered, mixed-talent Na-MnOx; incorporated Na+ is readily exchanged for H+ by subsequent acid rinsing to form a more crystalline H-MnOx phase. For both Na-MnOx and H-MnOx forms, controlled pore-fluid removal yields either densified, yet still mesoporous, xerogels or low-density aerogels (prepared by drying from supercritical CO2). The performance of these MnOx nanoarchitectures as filtration media is assessed using dynamic-challenge microbreakthrough protocols. We observe technologically relevant sorption capacities under both dry conditions and wet (80% relative humidity) for each of the three toxic industrial chemicals investigated. The Na-MnOx xerogels and aerogels provide optimal performance with the aerogel exhibiting maximum sorption capacities of 39, 200, and 680 mg g(-1) for NH3, SO2, and H2S, respectively. Postbreakthrough characterization using X-ray photoelectron spectroscopy (XPS) and diffuse-reflectance infrared Fourier transform spectroscopy (DRIFTS) confirms that NH3 is captured and partially protonated within the MnOx structure, while SO2 undergoes oxidation by the redox-active oxide to form adsorbed sulfate at the MnOx surface. Hydrogen sulfide is also oxidized to form a combination of sulfate and sulfur/polysulfide products, concomitant with a decrease in the average Mn oxidation state from 3.43 to 2.94 and generation of a MnOOH phase. C1 [Long, Jeffrey W.] US Naval Res Lab, Surface Chem Branch, Code 6170, Washington, DC 20375 USA. [Wallace, Jean M.] Nova Res Inc, Alexandria, VA 22308 USA. [Peterson, Gregory W.] US Army, Res Dev & Engn Command, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. [Huynh, Kim] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA. RP Long, JW (reprint author), US Naval Res Lab, Surface Chem Branch, Code 6170, Washington, DC 20375 USA. EM jeffrey.long@nrl.navy.mil FU U.S. Office of Naval Research; Edgewood Chemical Biological Center (Aberdeen, MD); U.S. Defense Threat Reduction Agency FX J.W.L. acknowledges the support of the U.S. Office of Naval Research and Edgewood Chemical Biological Center (Aberdeen, MD). G.W.P. and K.L.T.H. acknowledge the support of the U.S. Defense Threat Reduction Agency. NR 66 TC 1 Z9 1 U1 14 U2 58 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1944-8244 J9 ACS APPL MATER INTER JI ACS Appl. Mater. Interfaces PD JAN 20 PY 2016 VL 8 IS 2 BP 1184 EP 1193 DI 10.1021/acsami.5b09508 PG 10 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA DB6UL UT WOS:000368651100016 PM 26741498 ER PT J AU Pittman, PR McClain, D Quinn, X Coonan, KM Mangiafico, J Makuch, RS Morrill, J Peters, CJ AF Pittman, Phillip R. McClain, David Quinn, Xiaofei Coonan, Kevin M. Mangiafico, Joseph Makuch, Richard S. Morrill, John Peters, Clarence J. TI Safety and immunogenicity of a mutagenized, live attenuated Rift Valley fever vaccine, MP-12, in a Phase 1 dose escalation and route comparison study in humans SO VACCINE LA English DT Article DE MP-12; Rift Valley fever; Vaccine; Clinical trial ID VIRUS-VACCINE; AEROSOL CHALLENGE; RHESUS-MONKEYS; PREGNANT SHEEP; SAUDI-ARABIA; NSM GENES; PATHOGENICITY; PROTECTION; INFECTION; EFFICACY AB Rift Valley fever (RVF) poses a risk as a potential agent in bioterrorism or agroterrorism. A live attenuated RVF vaccine (RVF MP-12) has been shown to be safe and protective in animals and showed promise in two initial clinical trials. In the present study, healthy adult human volunteers (N=56) received a single injection of (a) RVF MP-12, administered subcutaneously (SQ) at a concentration of 10(4.7) plaque-forming units (pfu) (SQ Group); (b) RVF MP-12, administered intramuscularly (IM) at 10(3.4) pfu (IM Group 1); (c) RVF MP-12, administered IM at 10(4.4) pfu (IM Group 2); or (d) saline (Placebo Group). The vaccine was well tolerated by volunteers in all dose and route groups. Infrequent and minor adverse events were seen among recipients of both placebo and RVF MP-12. One subject had viremia detectable by direct plaque assay, and six subjects from IM Group 2 had transient low-titer viremia detectable only by nucleic acid amplification. Of the 43 vaccine recipients, 40 (93%) achieved neutralizing antibodies (measured as an 80% plaque reduction neutralization titer [PRNT80]) as well as RVF-specific IgM and IgG. The highest peak geometric mean PRNT80 titers were observed in IM Group 2. Of 34 RVF MP-12 recipients available for testing 1 year following inoculation, 28 (82%) remained seropositive (PRNT80 >= 1:20); this included 20 of 23 vaccinees (87%) from IM Group 2. The live attenuated RVF MP-12 vaccine was safe and immunogenic at the doses and routes studied. Given the need for an effective vaccine against RVF virus, further evaluation in humans is warranted. Published by Elsevier Ltd. C1 [Pittman, Phillip R.; McClain, David; Quinn, Xiaofei; Coonan, Kevin M.; Mangiafico, Joseph; Makuch, Richard S.; Morrill, John; Peters, Clarence J.] US Army, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. RP Pittman, PR (reprint author), US Army, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. EM phillip.r.pittman.civ@mail.mil FU U.S. Army Medical Materiel Development Activity, Medical Research and Materiel Command, U.S. Department of Defense FX We are most grateful to Elizabeth Brown, Ph.D., for her scholarly review and editing of this manuscript. We thank the skillful assistance of Denise Danner and Julie Hile in the completion of serology and viremia assays. The research described herein was sponsored by the U.S. Army Medical Materiel Development Activity, Medical Research and Materiel Command, U.S. Department of Defense. NR 42 TC 1 Z9 1 U1 0 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD JAN 20 PY 2016 VL 34 IS 4 BP 424 EP 429 DI 10.1016/j.vaccine.2015.12.030 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA DB9WJ UT WOS:000368868100006 PM 26718688 ER PT J AU Nallon, EC Schnee, VP Bright, CJ Polcha, MP Li, QL AF Nallon, Eric C. Schnee, Vincent P. Bright, Collin J. Polcha, Michael P. Li, Qiliang TI Discrimination Enhancement with Transient Feature Analysis of a Graphene Chemical Sensor SO ANALYTICAL CHEMISTRY LA English DT Article ID GAS SENSORS; ARRAYS; LAYER AB A graphene chemical sensor is subjected to a set of structurally and chemically similar hydrocarbon compounds consisting of toluene, o-xylene, p-xylene, and mesitylene. The fractional change in resistance of the sensor upon exposure to these compounds exhibits a similar response magnitude among compounds, whereas large variation is observed within repetitions for each compound, causing a response overlap. Therefore, traditional features depending on maximum response change will cause confusion during further discrimination and classification analysis. More robust features that are less sensitive to concentration, sampling, and drift variability would provide higher quality information. In this work, we have explored the advantage of using transient-based exponential fitting coefficients to enhance the discrimination of similar compounds. The advantages of such feature analysis to discriminate each compound is evaluated using principle component analysis (PCA). In addition, machine learning-based classification algorithms were used to compare the prediction accuracies when using fitting coefficients as features. The additional features greatly enhanced the discrimination between compounds while performing PCA and also improved the prediction accuracy by 34% when using linear discrimination analysis. C1 [Nallon, Eric C.; Schnee, Vincent P.] US Army, RDECOM CERDEC Night Vis & Elect Sensors Directora, Ft Belvoir, VA 22060 USA. [Nallon, Eric C.; Li, Qiliang] George Mason Univ, Dept Elect & Comp Engn, Fairfax, VA 22030 USA. [Polcha, Michael P.] Fulcrum IT Serv, Centerville, VA 20120 USA. [Bright, Collin J.] CACI Int Inc, Arlington, VA 22201 USA. RP Nallon, EC (reprint author), 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA. EM eric.c.nallon.civ@mail.mil NR 32 TC 1 Z9 1 U1 9 U2 17 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0003-2700 EI 1520-6882 J9 ANAL CHEM JI Anal. Chem. PD JAN 19 PY 2016 VL 88 IS 2 BP 1401 EP 1406 DI 10.1021/acs.analchem.5b04050 PG 6 WC Chemistry, Analytical SC Chemistry GA DB5OA UT WOS:000368562300048 PM 26674670 ER PT J AU Beal, SA Osterberg, EC Zdanowicz, CM Fisher, DA AF Beal, Samuel A. Osterberg, Erich C. Zdanowicz, Christian M. Fisher, David A. TI Response to Comment on "Ice Core Perspective on Mercury Pollution during the Past 600 Years" SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Letter ID ARCHIVES C1 [Beal, Samuel A.] US Army, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Osterberg, Erich C.] Dartmouth Coll, Dept Earth Sci, Hanover, NH 03755 USA. [Zdanowicz, Christian M.] Uppsala Univ, Dept Earth Sci, S-75105 Uppsala, Sweden. [Fisher, David A.] Univ Ottawa, Dept Earth Sci, Ottawa, ON K1N 6N5, Canada. RP Beal, SA (reprint author), US Army, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. EM samuel.beal@usace.army.mil OI Zdanowicz, Christian/0000-0002-1045-5063 NR 6 TC 0 Z9 0 U1 2 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD JAN 19 PY 2016 VL 50 IS 2 BP 1068 EP 1069 DI 10.1021/acs.est.5b05444 PG 2 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA DB5OL UT WOS:000368563400062 PM 26709862 ER PT J AU Schultz, BT Teigler, JE Pissani, F Oster, AF Kranias, G Alter, G Marovich, M Eller, MA Dittmer, U Robb, ML Kim, JH Michael, NL Bolton, D Streeck, H AF Schultz, Bruce T. Teigler, Jeffrey E. Pissani, Franco Oster, Alexander F. Kranias, Gregory Alter, Galit Marovich, Mary Eller, Michael A. Dittmer, Ulf Robb, Merlin L. Kim, Jerome H. Michael, Nelson L. Bolton, Diane Streeck, Hendrik TI Circulating HIV-Specific Interleukin-21(+)CD4(+) T Cells Represent Peripheral Tfh Cells with Antigen-Dependent Helper Functions SO IMMUNITY LA English DT Article ID CHRONIC VIRAL-INFECTION; ANTIBODY-RESPONSES; VACCINE DEVELOPMENT; EFFICACY TRIAL; DIFFERENTIATION; IL-21; PROLIFERATION; INDUCTION; CYTOKINE; PROTEINS AB A central effort in HIV vaccine development is to generate protective broadly neutralizing antibodies, a process dependent on T follicular helper (Tfh) cells. The feasibility of using peripheral blood counterparts of lymph node Tfh cells to assess the immune response and the influence of viral and vaccine antigens on their helper functions remain obscure. We assessed circulating HIV-specific IL-21(+) CD4(+) T cells and showed transcriptional and phenotypic similarities to lymphoid Tfh cells, and hence representing peripheral Tfh (pTfh) cells. pTfh cells were functionally active and B cell helper quality differed depending on antigen specificity. Furthermore, we found higher frequency of pTfh cells in peripheral blood mononuclear cell specimens from the ALVAC+AIDSVAX (RV144) HIV vaccine trial associated with protective antibody responses compared to the non-protective DNA+Ad5 vaccine trial. Together, we identify IL-21(+) CD4(+) T cells as pTfh cells, implicating them as key populations in the generation of vaccine-evoked antibody responses. C1 [Schultz, Bruce T.; Teigler, Jeffrey E.; Pissani, Franco; Oster, Alexander F.; Kranias, Gregory; Marovich, Mary; Eller, Michael A.; Robb, Merlin L.; Kim, Jerome H.; Michael, Nelson L.; Bolton, Diane; Streeck, Hendrik] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. [Schultz, Bruce T.; Teigler, Jeffrey E.; Pissani, Franco; Oster, Alexander F.; Kranias, Gregory; Marovich, Mary; Eller, Michael A.; Robb, Merlin L.; Bolton, Diane; Streeck, Hendrik] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD 20817 USA. [Schultz, Bruce T.; Streeck, Hendrik] Univ Duisburg Essen, Univ Hosp Essen, Inst HIV Res, D-45147 Essen, Germany. [Alter, Galit] Ragon Inst MGH MIT & Harvard, Cambridge, MA 02139 USA. [Dittmer, Ulf] Univ Duisburg Essen, Univ Hosp Essen, Inst Virol, D-45147 Essen, Germany. [Kim, Jerome H.] Int Vaccine Inst, Seoul 151742, South Korea. RP Streeck, H (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. EM hendrik.streeck@uk-essen.de FU U.S. NIH [R01 AI091450-01, R01 AI094602-01]; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-11-2-0174]; U.S. Department of Defense (DOD) [W81XWH-11-2-0174] FX We would like to thank Dr. Madelene Lindqvist and Dr. Jan van Lunzen for their help with the manuscript. This work was funded by the U.S. NIH (R01 AI091450-01 and R01 AI094602-01) and a cooperative agreement (W81XWH-11-2-0174) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense (DOD). The reagents HIV-1 PTE Gag and Env Peptides were obtained through the NIH AIDS Reagent Program, Division of AIDS, NIAID, NIH; human rIL-2 was from Dr. Maurice Gately, Hoffmann at La Roche Inc. The views expressed are those of the authors and should not be construed to represent the positions of the U.S. Army or the Department of Defense. NR 45 TC 16 Z9 16 U1 2 U2 6 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 1074-7613 EI 1097-4180 J9 IMMUNITY JI Immunity PD JAN 19 PY 2016 VL 44 IS 1 BP 167 EP 178 DI 10.1016/j.immuni.2015.12.011 PG 12 WC Immunology SC Immunology GA DB2NU UT WOS:000368347000021 PM 26795249 ER PT J AU Martin, MJ Eckert, MJ Schreiber, MA AF Martin, Matthew J. Eckert, Matthew J. Schreiber, Martin A. TI Relationship of a Mandated 1-Hour Evacuation Policy and Outcomes for Combat Casualties SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Editorial Material ID IN-HOSPITAL DEATHS; TRAUMA CARE C1 [Martin, Matthew J.; Eckert, Matthew J.] Madigan Army Med Ctr, Dept Surg, Tacoma, WA 98431 USA. [Schreiber, Martin A.] Oregon Hlth & Sci Univ, Dept Surg, Portland, OR 97201 USA. RP Martin, MJ (reprint author), US Army, Med Corps, Madigan Army Med Ctr, Dept Surg, 9040-A Fitzsimmons Ave, Tacoma, WA 98431 USA. EM matthew.j.martin16.mil@mail.mil NR 9 TC 0 Z9 0 U1 0 U2 2 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 0098-7484 EI 1538-3598 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD JAN 19 PY 2016 VL 315 IS 3 BP 293 EP 294 DI 10.1001/jama.2015.18744 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA DB2WN UT WOS:000368371400026 PM 26784777 ER PT J AU Ganin, AA Massaro, E Gutfraind, A Steen, N Keisler, JM Kott, A Mangoubi, R Linkov, I AF Ganin, Alexander A. Massaro, Emanuele Gutfraind, Alexander Steen, Nicolas Keisler, Jeffrey M. Kott, Alexander Mangoubi, Rami Linkov, Igor TI Operational resilience: concepts, design and analysis SO SCIENTIFIC REPORTS LA English DT Article ID INFRASTRUCTURE SYSTEMS; DYNAMICAL NETWORKS; COMPLEX NETWORKS; FRAMEWORK; FRAGILITY; FAILURES AB Building resilience into today's complex infrastructures is critical to the daily functioning of society and its ability to withstand and recover from natural disasters, epidemics, and cyber-threats. This study proposes quantitative measures that capture and implement the definition of engineering resilience advanced by the National Academy of Sciences. The approach is applicable across physical, information, and social domains. It evaluates the critical functionality, defined as a performance function of time set by the stakeholders. Critical functionality is a source of valuable information, such as the integrated system resilience over a time interval, and its robustness. The paper demonstrates the formulation on two classes of models: 1) multi-level directed acyclic graphs, and 2) interdependent coupled networks. For both models synthetic case studies are used to explore trends. For the first class, the approach is also applied to the Linux operating system. Results indicate that desired resilience and robustness levels are achievable by trading off different design parameters, such as redundancy, node recovery time, and backup supply available. The nonlinear relationship between network parameters and resilience levels confirms the utility of the proposed approach, which is of benefit to analysts and designers of complex systems and networks. C1 [Ganin, Alexander A.; Massaro, Emanuele; Steen, Nicolas; Linkov, Igor] US Army, Corps Engineers, Engineer Res & Dev Ctr, Environm Lab, Concord, MA 01742 USA. [Ganin, Alexander A.] Univ Virginia, Dept Syst & Informat Engn, Charlottesville, VA 22904 USA. [Massaro, Emanuele] Carnegie Mellon Univ, Dept Civil & Environm Engn, Pittsburgh, PA 15213 USA. [Gutfraind, Alexander] Univ Illinois, Sch Publ Hlth, Chicago, IL 60612 USA. [Keisler, Jeffrey M.] Univ Massachusetts, Coll Management, Boston, MA 02125 USA. [Kott, Alexander] US Army, Res Lab, Network Sci Div, Adelphi, MD 20783 USA. [Mangoubi, Rami] Charles Stark Draper Lab, Cambridge, MA 02139 USA. RP Linkov, I (reprint author), US Army, Corps Engineers, Engineer Res & Dev Ctr, Environm Lab, Concord, MA 01742 USA. EM Igor.Linkov@usace.army.mil OI Ganin, Alexander/0000-0003-2193-0373 NR 50 TC 6 Z9 6 U1 10 U2 35 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD JAN 19 PY 2016 VL 6 AR 19540 DI 10.1038/srep19540 PG 12 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DB1RL UT WOS:000368286400001 PM 26782180 ER PT J AU Lee, YS Lewis, JA Ippolito, DL Hussainzada, N Lein, PJ Jackson, DA Stallings, JD AF Lee, Young S. Lewis, John A. Ippolito, Danielle L. Hussainzada, Naissan Lein, Pamela J. Jackson, David A. Stallings, Jonathan D. TI Repeated exposure to neurotoxic levels of chlorpyrifos alters hippocampal expression of neurotrophins and neuropeptides SO TOXICOLOGY LA English DT Article DE Chlorpyrifos; Cholinesterase inhibition; Gene expression; Microarray; miRNA Organophosphorus pesticide ID LONG-TERM EXPOSURE; NEUROBEHAVIORAL PERFORMANCE; ORGANOPHOSPHATE PESTICIDES; UP-REGULATION; RNA-SEQ; WORKERS; MEMORY; NEURONS; RATS; CARBAMATE AB Chlorpyrifos (CPF), an organophosphorus pesticide (OP), is one of the most widely used pesticides in the world. Subchronic exposures to CPF that do not cause cholinergic crisis are associated with problems in cognitive function (i.e., learning and memory deficits), but the biological mechanism(s) underlying this association remain speculative. To identify potential mechanisms of subchronic CPF neurotoxicity, adult male Long Evans (LE) rats were administered CPF at 3 or 10 mg/kg/d (s.c.) for 21 days. We quantified mRNA and non-coding RNA (ncRNA) expression profiles by RNA-seq, microarray analysis and small ncRNA sequencing technology in the CA1 region of the hippocampus. Hippocampal slice immunohistochemistry was used to determine CPF-induced changes in protein expression and localization patterns. Neither dose of CPF caused overt clinical signs of cholinergic toxicity, although after 21 days of exposure, cholinesterase activity was decreased to 58% or 13% of control levels in the hippocampus of rats in the 3 or 10 mg/kg/d groups, respectively. Differential gene expression in the CA1 region of the hippocampus was observed only in the 10 mg/kg/d dose group relative to controls. Of the 1382 differentially expressed genes identified by RNA-seq and microarray analysis, 67 were common to both approaches. Differential expression of six of these genes (Bdnf,Cort, Crhbp, Nptx2, Npy and Pnoc) was verified in an independent CPF exposure study; immunohistochemistry demonstrated that CRHBP and NPY were elevated in the CAl region of the hippocampus at 10 mg/kg/d CPF. Gene ontology enrichment analysis suggested association of these genes with receptor-mediated cell survival signaling pathways. miR132/212 was also elevated in the CAl hippocampal region, which may play a role in the disruption of neurotrophin-mediated cognitive processes after CPF administration. These findings identify potential mediators of CPF-induced neurobehavioral deficits following subchronic exposure to CPF at a level that inhibits hippocampal cholinesterase to less than 20% of control. An equally significant finding is that subchronic exposure to CPF at a level that produces more moderate inhibition of hippocampal cholinesterase (approximately 50% of control) does not produce a discernable change in gene expression. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY license. C1 [Lee, Young S.; Hussainzada, Naissan] Oak Ridge Inst Sci & Engn, Oak Ridge, TN 37831 USA. [Lee, Young S.; Lewis, John A.; Ippolito, Danielle L.; Hussainzada, Naissan; Jackson, David A.; Stallings, Jonathan D.] US Army, Ctr Environm Hlth Res USACEHR, Frederick, MD 21702 USA. [Lein, Pamela J.] Univ Calif Davis, Sch Vet Med, Dept Mol Biosci, Davis, CA 95616 USA. RP Stallings, JD (reprint author), US Army, Ctr Environm Hlth Res USACEHR, Frederick, MD 21702 USA. EM jonathan.d.stallings.mil@mail.mil OI Stallings, Jonathan/0000-0002-6430-5888 FU NIEHS NIH HHS [#ES016308, R01 ES016308] NR 45 TC 1 Z9 2 U1 1 U2 7 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0300-483X J9 TOXICOLOGY JI Toxicology PD JAN 18 PY 2016 VL 340 BP 53 EP 62 DI 10.1016/j.tox.2016.01.001 PG 10 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA DE8QS UT WOS:000370902100007 PM 26775027 ER PT J AU Ratliff, ML Mishra, M Frank, MB Guthridge, JM Webb, CF AF Ratliff, Michelle L. Mishra, Meenu Frank, Mark B. Guthridge, Joel M. Webb, Carol F. TI The Transcription Factor ARID3a Is Important for In Vitro Differentiation of Human Hematopoietic Progenitors SO JOURNAL OF IMMUNOLOGY LA English DT Article ID SYSTEMIC-LUPUS-ERYTHEMATOSUS; B-CELL DIFFERENTIATION; DNA-BINDING PROTEINS; STEM-CELL; FACTOR BRIGHT; MYELOID LINEAGE; RINGER GENE; V-REGION; FAMILY; EXPRESSION AB We recently reported that the transcription factor ARID3a is expressed in a subset of human hematopoietic progenitor stem cells in both healthy individuals and in patients with systemic lupus erythematosus. Numbers of ARID3a(+) lupus hematopoietic stem progenitor cells were associated with increased production of autoreactive Abs when those cells were introduced into humanized mouse models. Although ARID3a/Bright knockout mice died in utero, they exhibited decreased numbers of hematopoietic stem cells and erythrocytes, indicating that ARID3a is functionally important for hematopoiesis in mice. To explore the requirement for ARID3a for normal human hematopoiesis, hematopoietic stem cell progenitors from human cord blood were subjected to both inhibition and overexpression of ARID3a in vitro. Inhibition of ARID3a resulted in decreased B lineage cell production accompanied by increases in cells with myeloid lineage markers. Overexpression of ARID3a inhibited both myeloid and erythroid differentiation. Additionally, inhibition of ARID3a in hematopoietic stem cells resulted in altered expression of transcription factors associated with hematopoietic lineage decisions. These results suggest that appropriate regulation of ARID3a is critical for normal development of both myeloid and B lineage pathways. C1 [Ratliff, Michelle L.; Frank, Mark B.; Guthridge, Joel M.; Webb, Carol F.] Oklahoma Med Res Fdn, Oklahoma City, OK 73104 USA. [Mishra, Meenu] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Webb, Carol F.] Univ Oklahoma, Hlth Sci Ctr, Dept Microbiol & Immunol, Oklahoma City, OK 73104 USA. [Webb, Carol F.] Univ Oklahoma, Hlth Sci Ctr, Dept Cell Biol, Oklahoma City, OK 73104 USA. RP Webb, CF (reprint author), Univ Oklahoma, Hlth Sci Ctr, Dept Med, Div Rheumatol, 800 Res Pkwy,Suite 418, Oklahoma City, OK 73104 USA. EM carol-webb@ouhsc.edu OI Webb, Carol/0000-0003-4164-9634 FU March of Dimes; National Institutes of Health [AI09043, AI044215, P30 AR053483, U19-AI062629-10] FX This work was supported by the March of Dimes, National Institutes of Health Grants AI09043 and AI044215 ( to C. F. W.), P30 AR053483 (Phenotyping Core support; to J. M. G.), and U19-AI062629-10 ( K. Mark Coggeshall, principal investigator; pilot, to C.F.W.). NR 65 TC 1 Z9 1 U1 0 U2 2 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 EI 1550-6606 J9 J IMMUNOL JI J. Immunol. PD JAN 15 PY 2016 VL 196 IS 2 BP 614 EP 623 DI 10.4049/jimmunol.1500355 PG 10 WC Immunology SC Immunology GA DA8QX UT WOS:000368072100018 PM 26685208 ER PT J AU Welch, RD Ayaz, SI Lewis, LM Unden, J Chen, JY Mika, VH Saville, B Tyndall, JA Nash, M Buki, A Barzo, P Hack, D Tortella, FC Schmid, K Hayes, RL Vossough, A Sweriduk, ST Bazarian, JJ AF Welch, Robert D. Ayaz, Syed I. Lewis, Lawrence M. Unden, Johan Chen, James Y. Mika, Valerie H. Saville, Ben Tyndall, Joseph A. Nash, Marshall Buki, Andras Barzo, Pal Hack, Dallas Tortella, Frank C. Schmid, Kara Hayes, Ronald L. Vossough, Arastoo Sweriduk, Stephen T. Bazarian, Jeffrey J. TI Ability of Serum Glial Fibrillary Acidic Protein, Ubiquitin C-Terminal Hydrolase-L1, and S100B To Differentiate Normal and Abnormal Head Computed Tomography Findings in Patients with Suspected Mild or Moderate Traumatic Brain Injury SO JOURNAL OF NEUROTRAUMA LA English DT Article ID NEW-ORLEANS CRITERIA; INTRACRANIAL LESIONS; NEUROSURGICAL INTERVENTION; RULE; BIOMARKERS; MANAGEMENT; S100-BETA; DIAGNOSIS; ACCURACY; BLOOD AB Head computed tomography (CT) imaging is still a commonly obtained diagnostic test for patients with minor head injury despite availability of clinical decision rules to guide imaging use and recommendations to reduce radiation exposure resulting from unnecessary imaging. This prospective multicenter observational study of 251 patients with suspected mild to moderate traumatic brain injury (TBI) evaluated three serum biomarkers' (glial fibrillary acidic protein [GFAP], ubiquitin C-terminal hydrolase-L1 [UCH-L1] and S100B measured within 6h of injury) ability to differentiate CT negative and CT positive findings. Of the 251 patients, 60.2% were male and 225 (89.6%) had a presenting Glasgow Coma Scale score of 15. A positive head CT (intracranial injury) was found in 36 (14.3%). UCH-L1 was 100% sensitive and 39% specific at a cutoff value >40pg/mL. To retain 100% sensitivity, GFAP was 0% specific (cutoff value 0pg/mL) and S100B had a specificity of only 2% (cutoff value 30pg/mL). All three biomarkers had similar values for areas under the receiver operator characteristic curve: 0.79 (95% confidence interval; 0.70-0.88) for GFAP, 0.80 (0.71-0.89) for UCH-L1, and 0.75 (0.65-0.85) for S100B. Neither GFAP nor UCH-L1 curve values differed significantly from S100B (p=0.21 and p=0.77, respectively). In our patient cohort, UCH-L1 outperformed GFAP and S100B when the goal was to reduce CT use without sacrificing sensitivity. UCH-L1 values <40pg/mL could potentially have aided in eliminating 83 of the 215 negative CT scans. These results require replication in other studies before the test is used in actual clinical practice. C1 [Welch, Robert D.; Ayaz, Syed I.; Mika, Valerie H.] Wayne State Univ, Dept Emergency Med, Detroit, MI 48230 USA. [Lewis, Lawrence M.] Washington Univ, Dept Emergency Med, St Louis, MO USA. [Unden, Johan] Clin Sci Malmo, Dept Anesthesiol & Intens Care, Malmo, Sweden. [Chen, James Y.] Univ Calif San Diego Hlth Syst, Dept Radiol, San Diego, CA USA. [Saville, Ben] Berry Consultants, Austin, TX USA. [Tyndall, Joseph A.] Univ Florida, Dept Emergency Med, Gainesville, FL USA. [Nash, Marshall] Neurostudies Net, Decatur, GA USA. [Buki, Andras] Univ Pecs, Dept Neurosurg, Pecs, Hungary. [Barzo, Pal] Univ Szeged, Dept Neurosurg, Szeged, Hungary. [Hack, Dallas] US Army, Med Res & Mat Command, Ft Detrick, MD USA. [Tortella, Frank C.] Walter Reed Army Inst Res, Appl Neurobiol, Silver Spring, MD USA. [Schmid, Kara] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA. [Hayes, Ronald L.] Banyan Biomarkers Inc, Ctr Innovat Res, Alachua, FL USA. [Vossough, Arastoo] Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA. [Sweriduk, Stephen T.] Shields Hlth Care Grp, Dept Radiol, Brockton, MA USA. [Bazarian, Jeffrey J.] Univ Rochester, Sch Med, Dept Emergency Med, Rochester, NY USA. RP Welch, RD (reprint author), Wayne State Univ, Dept Emergency Med, Detroit, MI 48230 USA. EM rwelch@med.wayne.edu FU U.S. Army Medical Research and Material Command [W81XWH-06-1-0517, W81XWH-10-C-0251] FX This work is supported by the U.S. Army Medical Research and Material Command under Contract N. W81XWH-06-1-0517 and Contract N. W81XWH-10-C-0251. The views, opinions and/or findings contained in this report are those of the authors and should not be construed as an official Department of the Army position, policy or decision unless so designated by other documentation. NR 33 TC 3 Z9 4 U1 1 U2 7 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JAN 15 PY 2016 VL 33 IS 2 BP 203 EP 214 DI 10.1089/neu.2015.4149 PG 12 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA DA7PH UT WOS:000367995800006 PM 26467555 ER PT J AU Munday, LB Crone, JC Knap, J AF Munday, Lynn B. Crone, Joshua C. Knap, Jaroslaw TI Prismatic and helical dislocation loop generation from defects SO ACTA MATERIALIA LA English DT Article DE Dislocation dynamics; Void growth; Image stress ID VOID GROWTH; DYNAMICS SIMULATIONS; MODEL; DEFORMATION; INCLUSION; CRYSTALS AB Plastic deformation induced by stress concentrations near crystal defects occurs through the generation of prismatic dislocation loops (PDL). The production of PDLs leads to void growth and particle decoherence. In this work we use dislocation dynamics simulations to characterize two mechanisms for PDL formation. The first mechanism corresponds to a classical model of PDL generation from dislocation nucleation. The second mechanism considers PDL generation through cross-slip of a screw dislocation intersecting the particle. We systematically study the effect of the crystal lattice and defect type on PDL generation for both mechanisms as a function of pressure. The simulations show image stresses produced by the dislocation's interaction with the free surface of a void suppresses PDL generation. The highest PDL generation rates are found for a dislocation nucleated from a void in a body-centered cubic lattice. Our simulations also show helical coiling of screw dislocations produces a continuous emission of PDLs without the need for dislocation nucleation at pressures as low as 1.0 GPa. Published by Elsevier Ltd on behalf of Acta Materialia Inc. C1 [Munday, Lynn B.; Crone, Joshua C.; Knap, Jaroslaw] US Army Res Lab, RDRL CIH C, Aberdeen Proving Ground, MD 21005 USA. RP Munday, LB (reprint author), US Army Res Lab, RDRL CIH C, Aberdeen Proving Ground, MD 21005 USA. EM lynn.b.munday.civ@mail.mil FU U.S. Army Research Laboratory's Enterprise for Multiscale Research of Materials FX Support of the U.S. Army Research Laboratory's Enterprise for Multiscale Research of Materials is gratefully acknowledged. Computing support was provided by the DoD Supercomputing Resource Center located at the U.S. Army Research Laboratory. NR 33 TC 1 Z9 1 U1 5 U2 11 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6454 EI 1873-2453 J9 ACTA MATER JI Acta Mater. PD JAN 15 PY 2016 VL 103 BP 217 EP 228 DI 10.1016/j.actamat.2015.09.056 PG 12 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA DA2MU UT WOS:000367630500022 ER PT J AU Son, HK Sivakumar, S Rood, MJ Kim, BJ AF Son, H. K. Sivakumar, S. Rood, M. J. Kim, B. J. TI Electrothermal adsorption and desorption of volatile organic compounds on activated carbon fiber cloth SO JOURNAL OF HAZARDOUS MATERIALS LA English DT Article DE Adsorption; Desorption; Activated carbon fiber cloth; Volatile organic compounds; Set-point concentration ID AIR-POLLUTION CONTROL; SWING ADSORPTION; CRYOGENIC CONDENSATION; BIOTRICKLING FILTERS; LOAD EQUALIZATION; BENZENE VAPORS; REMOVAL; PERFORMANCE; STREAMS; TOLUENE AB Adsorption is an effective means to selectively remove volatile organic compounds (VOCs) from industrial gas streams and is particularly of use for gas streams that exhibit highly variable daily concentrations of VOCs. Adsorption of such gas streams by activated carbon fiber cloths (ACFCs) and subsequent controlled desorption can provide gas streams of well-defined concentration that can then be more efficiently treated by biofiltration than streams exhibiting large variability in concentration. In this study, we passed VOC-containing gas through an ACFC vessel for adsorption and then desorption in a concentration-controlled manner via electrothermal heating. Set-point concentrations (40-900 ppm(v)) and superficial gas velocity (6.3-9.9 m/s) were controlled by a data acquisition and control system. The results of the average VOC desorption, desorption factor and VOC in-and-out ratio were calculated and compared for various gas set-point concentrations and superficial gas velocities. Our results reveal that desorption is strongly dependent on the set-point concentration and that the VOC desorption rate can be successfully equalized and controlled via an electrothermal adsorption system. (C) 2015 Elsevier B.V. All rights reserved. C1 [Son, H. K.] Kosin Univ, Dept Hlth & Environm, Busan, South Korea. [Sivakumar, S.] Pusan Natl Univ, Coll Nat Resource & Life Sci, Dept Bioenvironm Energy, Miryang Si 627706, Gyeongsangnam D, South Korea. [Rood, M. J.] Univ Illinois, Dept Civil & Environm Engn, Urbana, IL 61801 USA. [Kim, B. J.] US Army Engineer Res & Dev Ctr ERDC CERL, Construct Engn Res Lab, Champaign, IL USA. RP Sivakumar, S (reprint author), Pusan Natl Univ, Coll Nat Resource & Life Sci, Dept Bioenvironm Energy, Miryang Si 627706, Gyeongsangnam D, South Korea. EM ssivaphd@yahoo.com FU Korea Environmental Industry and Technology Institute FX This work was financially supported by the Korea Environmental Industry and Technology Institute. NR 43 TC 5 Z9 6 U1 29 U2 127 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3894 EI 1873-3336 J9 J HAZARD MATER JI J. Hazard. Mater. PD JAN 15 PY 2016 VL 301 BP 27 EP 34 DI 10.1016/j.jhazmat.2015.08.040 PG 8 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA CZ9GY UT WOS:000367407200004 PM 26342148 ER PT J AU Fraga, M Vilarino, N Louzao, MC Fernandez, DA Poli, M Botana, LM AF Fraga, Maria Vilarino, Natalia Carmen Louzao, M. Fernandez, Diego A. Poli, Mark Botana, Luis M. TI Detection of palytoxin-like compounds by a flow cytometry-based immunoassay supported by functional and analytical methods SO ANALYTICA CHIMICA ACTA LA English DT Article DE Palytoxin; Palytoxin-like molecules; Microsphere-based array; Flow-cytometry system; Screening method ID SHELLFISH POISONING TOXINS; OSTREOPSIS-CF. SIAMENSIS; OF-THE-ART; MASS-SPECTROMETRY; 1ST EVIDENCE; OVATOXIN-A; ANALOGS; SYSTEM; ASSAY; INHIBITION AB Palytoxin (PLTX) is a complex marine toxin produced by zoanthids (i.e. Palythoa), dinoflagellates (Ostreopsis) and cyanobacteria (Trichodesmium). PLTX outbreaks are usually associated with Indo-Pacific waters, however their recent repeated occurrence in Mediterranean-European Atlantic coasts demonstrate their current worldwide distribution. Human sickness and fatalities have been associated with toxic algal blooms and ingestion of seafood contaminated with PLTX-like molecules. These toxins represent a serious threat to human health. There is an immediate need to develop easy-to-use, rapid detection methods due to the lack of validated protocols for their detection and quantification. We have developed an immuno-detection method for PLTX-like molecules based on the use of microspheres coupled to flow-cytometry detection (Luminex 200 (TM)). The assay consisted of the competition between free PLTX-like compounds in solution and PLTX immobilized on the surface of microspheres for binding to a specific monoclonal anti-PLTX antibody. This method displays an IC50 of 1.83 +/- 0.21 nM and a dynamic range of 0.47-6.54 nM for PLTX. An easy-to-perform extraction protocol, based on a mixture of methanol and acetate buffer, was applied to spiked mussel samples providing a recovery rate of 104 +/- 8% and a range of detection from 374 +/- 81 to 4430 +/- 150 mu g kg(-1) when assayed with this method. Extracts of Ostreopsis cf. siamensis and Palythoa tuberculosa were tested and yielded positive results for PLTX-like molecules. However, the data obtained for the coral sample suggested that this antibody did not detect 42-OH-PLTX efficiently. The same samples were further analyzed using a neuroblastoma cytotoxicity assay and UPLC-IT-TOF spectrometry, which also pointed to the presence of PLTX-like compounds. Therefore, this single detection method for PLTX provides a semi-quantitative tool useful for the screening of PLTX-like molecules in different matrixes. (C) 2015 Elsevier B.V. All rights reserved. C1 [Fraga, Maria; Vilarino, Natalia; Carmen Louzao, M.; Fernandez, Diego A.; Botana, Luis M.] Univ Santiago de Compostela, Fac Vet, Dept Farmacol, Lugo 27002, Spain. [Poli, Mark] US Army Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD USA. RP Vilarino, N (reprint author), Fac Vet, Dept Farmacol, Campus Univ, Lugo 27002, Spain. EM natalia.vilarino@usc.es; luis.botana@usc.es RI Fernandez Martinez, Diego Alberto/A-7663-2011; OI Fernandez Martinez, Diego Alberto/0000-0002-3336-5036; Vilarino, Natalia/0000-0001-6055-6359; Louzao, M. Carmen/0000-0002-3072-0637 FU FEDER; CDTI and Technological Funds - Ministerio de Economia y Competitividad, [AGL2012-40185-CO2-01, AGL2014-58210-R]; Conselleria de Cultura, Educacion e Ordenacion Universitaria [GRC2013-016]; Axencia Galega de Innovacion, Spain [ITC-20133020 SINTOX]; CDTI under ISIP Programme, Spain [IDI-20130304 APTAFOOD]; European Union's Seventh Framework Programme [312184 PHARMASEA] FX The research leading to these results has received funding from the following FEDER cofunded-grants. From CDTI and Technological Funds, supported by Ministerio de Economia y Competitividad, AGL2012-40185-CO2-01, AGL2014-58210-R, and Conselleria de Cultura, Educacion e Ordenacion Universitaria, GRC2013-016, and through Axencia Galega de Innovacion, Spain, ITC-20133020 SINTOX. From CDTI under ISIP Programme, Spain, IDI-20130304 APTAFOOD. From the European Union's Seventh Framework Programme managed by REA-Research Executive Agency (FP7/2007-2013) under grant agreement 312184 PHARMASEA. NR 49 TC 3 Z9 3 U1 3 U2 22 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0003-2670 EI 1873-4324 J9 ANAL CHIM ACTA JI Anal. Chim. Acta PD JAN 15 PY 2016 VL 903 BP 1 EP 12 DI 10.1016/j.aca.2015.09.040 PG 12 WC Chemistry, Analytical SC Chemistry GA CZ3ZY UT WOS:000367043900001 PM 26709295 ER PT J AU Zander, Z Yagloski, R DeCoste, J Zhang, DJ DeLacy, BG AF Zander, Zachary Yagloski, Raymond DeCoste, Jared Zhang, Dajie DeLacy, Brendan G. TI One-pot synthesis of high aspect ratio titanium dioxide nanorods using oxalic acid as a complexing agent SO MATERIALS LETTERS LA English DT Article DE TiO2; nanorods; titanium isopropoxide; oxalic acid; hydrothermal synthesis; one-pot synthesis ID NANOTUBE ARRAYS; OXIDE NANOTUBE; TIO2 NANOTUBES; NANOCRYSTALS; MECHANISMS AB We report the novel one-pot synthesis of high aspect ratio titanium dioxide (TiO2) nanorods using a simple hydrothermal technique. Specifically, oxalic acid and sodium hydroxide (NaOH) were used as additives to promote the conversion of titanium tetraisopropoxide (TTIP) into a one-dimensional TiO2 morphology. All resultant products were characterized by X-ray powder diffraction and scanning electron microscopy. Influential factors on the growth mechanisms of TiO2 nanorods are discussed. This approach contrasts the typical approach of using spherical TiO2 as a starting material in the fabrication of one-dimensional TiO2 structures, and instead allows for the direct synthesis of TiO2 nanorods from TTIP precursors. Published by Elsevier B.V. C1 [Zander, Zachary; Yagloski, Raymond; DeCoste, Jared; DeLacy, Brendan G.] US Army Edgewood Chem Biol Ctr, Res & Technol Directorate, Aberdeen Proving Ground, MD 21010 USA. [DeCoste, Jared] Leidos Inc, Gunpowder, MD 21010 USA. [Zhang, Dajie] Brimrose Technol Corp, Sparks, MD 21152 USA. RP DeLacy, BG (reprint author), US Army Edgewood Chem Biol Ctr, Res & Technol Directorate, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM brendan.g.delacy.civ@mail.mil FU Department of the Army Basic Research Program; Edgewood Chemical Biological Center FX This research was funded by the Department of the Army Basic Research Program and sponsored by the Edgewood Chemical Biological Center. NR 25 TC 1 Z9 1 U1 5 U2 14 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-577X EI 1873-4979 J9 MATER LETT JI Mater. Lett. PD JAN 15 PY 2016 VL 163 BP 39 EP 42 DI 10.1016/j.matlet.2015.10.041 PG 4 WC Materials Science, Multidisciplinary; Physics, Applied SC Materials Science; Physics GA CY0FI UT WOS:000366081400011 ER PT J AU Terzic, N Konstantinovic, J Tot, M Burojevic, J Djurkovic-Djakovic, O Srbljanovic, J Stajner, T Verbic, T Zlatovic, M Machado, M Albuquerque, IS Prudencio, M Sciotii, RJ Pecic, S D'Alessandro, S Taramelli, D Solaja, BA AF Terzic, Natasa Konstantinovic, Jelena Tot, Miklos Burojevic, Jovana Djurkovic-Djakovic, Olgica Srbljanovic, Jelena Stajner, Tijana Verbic, Tatjana Zlatovic, Mario Machado, Marta Albuquerque, Ines S. Prudencio, Miguel Sciotii, Richard J. Pecic, Stevan D'Alessandro, Sarah Taramelli, Donatella Solaja, Bogdan A. TI Reinvestigating Old Pharmacophores: Are 4-Aminoquinolines and Tetraoxanes Potential Two-Stage Antimalarials? SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID PLASMODIUM-FALCIPARUM MALARIA; CHLOROQUINE-RESISTANCE TRANSPORTER; LIVER STAGE; IN-VITRO; ANTIPLASMODIAL ACTIVITY; ARTEMISININ RESISTANCE; HYBRIDS SYNTHESIS; DRUGS; DERIVATIVES; ANALOGS AB The syntheses and antiplasmodial activities of various substituted aminoquinolines coupled to an adamantane carrier are described. The compounds exhibited pronounced in vitro and in vivo activity against Plasmodium berghei in the Thompson test. Tethering a fluorine atom to the aminoquinoline C(3) position afforded fluoroaminoquinolines that act as intrahepatocytic parasite inhibitors, with compound 25 having an IC50 = 0.31 mu M and reducing the liver load in mice by up to 92% at 80 mg/kg dose. Screening our peroxides as inhibitors of liver stage infection revealed that the tetraoxane pharmacophore itself is also an excellent liver stage P. berghei inhibitor (78: IC50 = 0.33 mu M). Up to 91% reduction of the parasite liver load in mice was achieved at 100 mg/kg. Examination of tetraoxane 78 against the transgenic 3D7 strain expressing luciferase under a gametocyte-specific promoter revealed its activity against stage IV-V Plasmodium falciparum gametocytes (IC50 = 1.16 +/- 0.37 mu M). To the best of our knowledge, compounds 25 and 78 are the first examples of either an 4-aminoquinoline or a tetraoxane liver stage inhibitors. C1 [Terzic, Natasa] Inst Chem Technol & Met, Belgrade 11000, Serbia. [Konstantinovic, Jelena; Tot, Miklos; Burojevic, Jovana; Verbic, Tatjana; Zlatovic, Mario; Solaja, Bogdan A.] Univ Belgrade, Fac Chem, Studentski Trg 16,POB 51, Belgrade 11158, Serbia. [Djurkovic-Djakovic, Olgica; Srbljanovic, Jelena; Stajner, Tijana] Univ Belgrade, Inst Med Res, Dr Subotica 4, Belgrade 11129, Serbia. [Machado, Marta; Albuquerque, Ines S.; Prudencio, Miguel] Univ Lisbon, Inst Med Mol, Fac Med, P-1649028 Lisbon, Portugal. [Sciotii, Richard J.] Walter Reed Army Inst Res, Expt Therapeut Branch, Silver Spring, MD 20910 USA. [Pecic, Stevan] Columbia Univ, Dept Med, Div Expt Therapeut, New York, NY 10032 USA. [D'Alessandro, Sarah; Taramelli, Donatella] Univ Milan, Dipartimento Sci Farmacol & Biomol, I-20133 Milan, Italy. RP Solaja, BA (reprint author), Univ Belgrade, Fac Chem, Studentski Trg 16,POB 51, Belgrade 11158, Serbia.; Prudencio, M (reprint author), Univ Lisbon, Inst Med Mol, Fac Med, P-1649028 Lisbon, Portugal. EM mprudencio@medicina.ulisboa.pt; bsolaja@chem.bg.ac.rs RI Zlatovic, Mario/E-5874-2015; Albuquerque, Ines/P-5325-2016; Verbic, Tatjana/Q-3529-2016; Konstantinovic, Jelena/Q-5813-2016; OI Zlatovic, Mario/0000-0003-4311-1731; Albuquerque, Ines/0000-0002-1108-0961; Verbic, Tatjana/0000-0002-6348-1644; Konstantinovic, Jelena/0000-0002-2572-8538; Pecic, Stevan/0000-0002-3706-8768; Solaja, Bogdan/0000-0002-9975-2725 FU Ministry of Science and Technological Development of Serbia [172008, 41019]; Serbian Academy of Sciences and Arts; Fundacao para a Ciencia e Tecnologia, Portugal [PTDC/SAUMIC/117060/2010]; Bill & Melinda Gates Foundation [OPP1040394] FX This research was supported by The Ministry of Science and Technological Development of Serbia (grant nos. 172008 and 41019), the Serbian Academy of Sciences and Arts, Fundacao para a Ciencia e Tecnologia, Portugal (grant PTDC/SAUMIC/117060/2010), the Bill & Melinda Gates Foundation (grant OPP1040394). The contents of this manuscript have been reviewed by the Walter Reed Army Institute of Research. There is no objection to its presentation or publication. NR 83 TC 1 Z9 1 U1 4 U2 19 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0022-2623 EI 1520-4804 J9 J MED CHEM JI J. Med. Chem. PD JAN 14 PY 2016 VL 59 IS 1 BP 264 EP 281 DI 10.1021/acs.jmedchem.5b01374 PG 18 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA DB5OV UT WOS:000368564400019 PM 26640981 ER PT J AU Owens, BD Garcia, EJ Alitz, CJ AF Owens, Brett D. Garcia, EStephan J. Alitz, Curt J. TI FASCIOTOMY FOR CHRONIC EXERTIONAL COMPARTMENT SYNDROME OF THE LEG SO JBJS ESSENTIAL SURGICAL TECHNIQUES LA English DT Editorial Material C1 [Owens, Brett D.] Brown Univ, Alpert Med Sch, 100 Butler Dr, Providence, RI 02906 USA. [Garcia, EStephan J.; Alitz, Curt J.] Keller Army Hosp, West Point, NY 10996 USA. RP Owens, BD (reprint author), Brown Univ, Alpert Med Sch, 100 Butler Dr, Providence, RI 02906 USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 2160-2204 J9 JBJS ESSENT SURG TEC JI JBJS Essent. Surg. Tech. PD JAN 13 PY 2016 VL 6 IS 1 AR e1 DI 10.2106/JBJS.ST.N.00118 PG 2 WC Surgery SC Surgery GA DG6LX UT WOS:000372197300001 ER PT J AU Li, Y Ho, J Wang, JC Li, ZM Zhong, GJ Zhu, L AF Li, Yue Ho, Janet Wang, Jianchuan Li, Zhong-Ming Zhong, Gan-Ji Zhu, Lei TI Understanding Nonlinear Dielectric Properties in a Biaxially Oriented Poly(vinylidene fluoride) Film at Both Low and High Electric Fields SO ACS APPLIED MATERIALS & INTERFACES LA English DT Article DE poly(vinylidene fluoride); ferroelectric; nonlinear dielectric property; high-voltage broadband dielectric spectroscopy; dipolar relaxation ID FERROELECTRIC POLYMERS; VINYLIDENE FLUORIDE; EFFECT TRANSISTORS; COPOLYMER; TRIFLUOROETHYLENE; RELAXATIONS; HYSTERESIS; ACTUATORS; CRYSTALS; ACETATE AB Understanding nonlinear dielectric behavior in polar polymers is crucial to their potential application as next generation high energy density and low loss dielectrics. In this work, we studied nonlinear dielectric properties of a biaxially oriented poly(vinylidene fluoride) (BOPVDF) film under both low and high electric fields. For fundamental nonlinear dielectric constants at low fields (<30 MV/m), Novocontrol high-voltage broadband dielectric spectroscopy (HVBDS) was accurate enough to measure up to the third harmonics. It was observed that the low-field dielectric nonlinearity for the BOPVDF disappeared above 10 Hz at room temperature, suggesting that the low-field dielectric nonlinearity originated from ionic migration of impurity ions rather than dipolar relaxation of the amorphous segments. Above the coercive field (E-C approximate to 70 MV/m), bipolar electric displacement-electric field (D-E) loop tests were used to extract the nonlinear behavior for pure PVDF crystals, which had a clear origin of ferroelectric switching of polar crystalline dipoles and domains and nonpolar-to-polar (alpha -> delta -> beta) phase transformations. By using HVBDS, it was observed that the ferroelectric switching of polar crystalline dipoles and domains in BOPVDF above the E-C always took place between 20 and 500 Hz regardless of a broad range of temperature from -30 to 100 degrees C. This behavior was drastically different from that of the amorphous PVDF dipoles, which had a strong dependence on frequency over orders of magnitude. C1 [Li, Yue; Wang, Jianchuan; Li, Zhong-Ming; Zhong, Gan-Ji] Sichuan Univ, Coll Polymer Sci & Engn, State Key Lab Polymer Mat Engn, Chengdu 610065, Sichuan, Peoples R China. [Li, Yue; Zhu, Lei] Case Western Reserve Univ, Dept Macromol Sci & Engn, Cleveland, OH 44106 USA. [Ho, Janet] US Army, Res Lab, RDRL SED C, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Wang, Jianchuan] Chongqing Univ, Coll Chem & Chem Engn, Chongqing 400044, Peoples R China. RP Wang, JC (reprint author), Sichuan Univ, Coll Polymer Sci & Engn, State Key Lab Polymer Mat Engn, Chengdu 610065, Sichuan, Peoples R China.; Zhu, L (reprint author), Case Western Reserve Univ, Dept Macromol Sci & Engn, Cleveland, OH 44106 USA.; Wang, JC (reprint author), Chongqing Univ, Coll Chem & Chem Engn, Chongqing 400044, Peoples R China. EM jxw319@cqu.edu.cn; lxz121@case.edu RI Li, Zhong-Ming/I-9785-2016; Zhu, Lei/C-8754-2013 OI Zhu, Lei/0000-0001-6570-9123 FU National Science Foundation [DMR-1402733]; China Scholarship Council; National Natural Science Foundation of China [51528302]; Army Research Office (ARO) [W911NF-13-1-0153] FX This work is supported by National Science Foundation (DMR-1402733). Y.L. and J.W. acknowledge financial support from China Scholarship Council. Partial support from the National Natural Science Foundation of China (Grant No. 51528302) is also acknowledged. The HVBDS instrument is supported by Army Research Office (ARO) under Award No. W911NF-13-1-0153. NR 38 TC 4 Z9 4 U1 17 U2 48 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1944-8244 J9 ACS APPL MATER INTER JI ACS Appl. Mater. Interfaces PD JAN 13 PY 2016 VL 8 IS 1 BP 455 EP 465 DI 10.1021/acsami.5b09368 PG 11 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA DB5OH UT WOS:000368563000056 PM 26698912 ER PT J AU Becker, CR Prokes, SM Love, CT AF Becker, Collin R. Prokes, S. M. Love, Corey T. TI Enhanced Lithiation Cycle Stability of ALD-Coated Confined a-Si Microstructures Determined Using In Situ AFM SO ACS APPLIED MATERIALS & INTERFACES LA English DT Article DE silicon; lithium ion; atomic force microscopy; in situ; battery ID LITHIUM-ION BATTERIES; ATOMIC LAYER DEPOSITION; AMORPHOUS-SILICON; ELECTROLYTE ADDITIVES; VINYLENE CARBONATE; FORCE MICROSCOPY; POUCH CELLS; ANODES; PERFORMANCE; NANOPARTICLES AB Microfabricated amorphous silicon (alpha-Si) pits similar to 4 mu m in diameter and 100 nm thick were fabricated to be partially confined in a nickel (Ni) current collector. Corresponding unconfined pillars were also fabricated. The samples were coated with 1.5, 3, or 6 nm of Al2O3 ALD. These samples were tested in electrolytes of 3:7 by weight ethylene carbonate:ethyl methyl carbonate (EC:EMC) with 1.2 M LiPF6 salt with and without 2% fluoroethylene carbonate (FEC) and in a pure FEC electrolyte with 10 wt % LiPF6. The samples were imaged with an atomic force microscope during electrochemical cycling to evaluate morphology evolution and solid electrolyte interphase (SEI) formation. The partially confined alpha-Si structures had superior cycle efficiency relative to the unconfined alpha-Si pillars. Additionally, samples with 3 nm of ALD achieved higher charge capacity and enhanced cycle life compared to samples without ALD, demonstrated thinner SEI formation, and after 10 cycles at a 1 C rate remained mostly intact and had actually decreased in diameter. Finally, the samples with 3 nm of ALD had better capacity retention in the baseline 3:7 EC:EMC than in either of the FEC containing electrolytes. C1 [Becker, Collin R.] US Army, Res Lab, Electrochem Branch, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Prokes, S. M.] US Navy, Res Lab, Elect Sci & Technol Div, Washington, DC 20375 USA. [Love, Corey T.] US Navy, Res Lab, Div Chem, Washington, DC 20375 USA. RP Becker, CR (reprint author), US Army, Res Lab, Electrochem Branch, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM Collin.r.becker.civ@mail.mil FU US Army Research Lab; Nanoscience Institute at the US Naval Research Lab FX We are grateful for financial support from the US Army Research Lab and Nanoscience Institute at the US Naval Research Lab. We thank John Moulder from PHI for the XPS measurements and Sam Delp from the US Army Research Lab for providing electrolytes. NR 37 TC 5 Z9 5 U1 19 U2 65 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1944-8244 J9 ACS APPL MATER INTER JI ACS Appl. Mater. Interfaces PD JAN 13 PY 2016 VL 8 IS 1 BP 530 EP 537 DI 10.1021/acsami.5b09544 PG 8 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA DB5OH UT WOS:000368563000064 PM 26672626 ER PT J AU Frei, JC Nyakatura, EK Zak, SE Bakken, RR Chandran, K Dye, JM Lai, JR AF Frei, Julia C. Nyakatura, Elisabeth K. Zak, Samantha E. Bakken, Russell R. Chandran, Kartik Dye, John M. Lai, Jonathan R. TI Bispecific Antibody Affords Complete Post-Exposure Protection of Mice from Both Ebola (Zaire) and Sudan Viruses SO SCIENTIFIC REPORTS LA English DT Article ID ENVELOPE GLYCOPROTEIN; NONHUMAN-PRIMATES; MONOCLONAL-ANTIBODIES; SYNTHETIC ANTIBODIES; CRYSTAL-STRUCTURE; INFECTION; PROPHYLAXIS; DISEASE; MODEL; GP2 AB Filoviruses (Ebola and Marburg) cause severe hemorrhagic fever. There are five species of ebolavirus; among these, the Ebola (Zaire) and Sudan viruses (EBOV and SUDV, respectively) are highly pathogenic and have both caused recurring, large outbreaks. However, the EBOV and SUDV glycoprotein (GP) sequences are 45% divergent and thus antigenically distinct. Few antibodies with cross-neutralizing properties have been described to date. We used antibody engineering to develop novel bispecific antibodies (Bis-mAbs) that are cross-reactive toward base epitopes on GP from EBOV and SUDV. These Bis-mAbs exhibit potent neutralization against EBOV and SUDV GP pseudotyped viruses as well as authentic pathogens, and confer a high degree (in one case 100%) post-exposure protection of mice from both viruses. Our studies show that a single agent that targets the GP base epitopes is sufficient for protection in mice; such agents could be included in panfilovirus therapeutic antibody cocktails. C1 [Frei, Julia C.; Nyakatura, Elisabeth K.; Lai, Jonathan R.] Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA. [Zak, Samantha E.; Bakken, Russell R.; Dye, John M.] US Army, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. [Chandran, Kartik] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA. RP Dye, JM (reprint author), US Army, Med Res Inst Infect Dis, Div Virol, 1425 Porter St, Ft Detrick, MD 21702 USA. EM john.m.dye1.civ@mail.mil; jon.lai@einstein.yu.edu FU NIH [U19 AI109762]; Irma T. Hirschl/Monique Weill-Caulier Research Scientist Award; NIH Cellular and Molecular Biology and Genetics Training Program [T32-GM007491]; DAAD (Deutscher Akademischer Austausch Dienst, German Academic Exchange Service); JSTO-DTRA project [CB3948] FX This work was supported by NIH grant U19 AI109762 (Centers for Excellence in Translational Research) to K.C., J.M.D. and J.R.L. and by an Irma T. Hirschl/Monique Weill-Caulier Research Scientist Award to J.R. L.J.C.F. was supported by NIH Cellular and Molecular Biology and Genetics Training Program T32-GM007491 and E.K.N. by a DAAD (Deutscher Akademischer Austausch Dienst, German Academic Exchange Service) fellowship. J.M.D. kindly acknowledges JSTO-DTRA project CB3948 for support Opinions, conclusions, interpretations, and recommendations are those of the authors and are not necessarily endorsed by the US. Army. The mention of trade names or commercial products does not constitute endorsement or recommendation for use by the Department of the Army or the Department of Defense. NR 44 TC 4 Z9 4 U1 3 U2 13 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD JAN 13 PY 2016 VL 6 AR 19193 DI 10.1038/srep19193 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DA9BO UT WOS:000368101700001 PM 26758505 ER PT J AU Watanabe, KH Mayo, M Jensen, KM Villeneuve, DL Ankley, GT Perkins, EJ AF Watanabe, Karen H. Mayo, Michael Jensen, Kathleen M. Villeneuve, Daniel L. Ankley, Gerald T. Perkins, Edward J. TI Predicting Fecundity of Fathead Minnows (Pimephales promelas) Exposed to Endocrine-Disrupting Chemicals Using a MATLAB (R)-Based Model of Oocyte Growth Dynamics SO PLOS ONE LA English DT Article ID TERM REPRODUCTION ASSAY; PITUITARY-GONADAL AXIS; COMPUTATIONAL MODEL; FISH; INHIBITOR; 17-BETA-TRENBOLONE; STEROIDOGENESIS; ECOTOXICOLOGY; BIOSYNTHESIS; KETOCONAZOLE AB Fish spawning is often used as an integrated measure of reproductive toxicity, and an indicator of aquatic ecosystem health in the context of forecasting potential population-level effects considered important for ecological risk assessment. Consequently, there is a need for flexible, widely-applicable, biologically-based models that can predict changes in fecundity in response to chemical exposures, based on readily measured biochemical endpoints, such as plasma vitellogenin (VTG) concentrations, as input parameters. Herein we describe a MATLAB1 version of an oocyte growth dynamics model for fathead minnows (Pimephales promelas) with a graphical user interface based upon a previously published model developed with MCSim software and evaluated with data from fathead minnows exposed to an androgenic chemical, 17 beta-trenbolone. We extended the evaluation of our new model to include six chemicals that inhibit enzymes involved in steroid biosynthesis: fadrozole, ketoconazole, propiconazole, prochloraz, fenarimol, and trilostane. In addition, for unexposed fathead minnows from group spawning design studies, and those exposed to the six chemicals, we evaluated whether the model is capable of predicting the average number of eggs per spawn and the average number of spawns per female, which was not evaluated previously. The new model is significantly improved in terms of ease of use, platform independence, and utility for providing output in a format that can be used as input into a population dynamics model. Model-predicted minimum and maximum cumulative fecundity over time encompassed the observed data for fadrozole and most propiconazole, prochloraz, fenarimol and trilostane treatments, but did not consistently replicate results fromketoconazole treatments. For average fecundity (eggs.female(-1).day(-1)), eggs per spawn, and the number of spawns per female, the range of model-predicted values generally encompassed the experimentally observed values. Overall, we found that the model predicts reproduction metrics robustly and its predictions capture the variability in the experimentally observed data. C1 [Watanabe, Karen H.] Oregon Hlth & Sci Univ, Inst Environm Hlth, Div Environm & Biomol Syst, Portland, OR 97201 USA. [Watanabe, Karen H.] Oregon Hlth & Sci Univ, Sch Publ Hlth, Portland, OR 97201 USA. [Mayo, Michael; Perkins, Edward J.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA. [Jensen, Kathleen M.; Villeneuve, Daniel L.; Ankley, Gerald T.] US EPA, Midcontinent Ecol Div, Duluth, MN USA. RP Watanabe, KH (reprint author), Oregon Hlth & Sci Univ, Inst Environm Hlth, Div Environm & Biomol Syst, Portland, OR 97201 USA. EM watanabk@ohsu.edu FU US Army Environmental Quality and Installations 6.1 Basic Research Program FX US Army Environmental Quality and Installations 6.1 Basic Research Program funding to KHW, MM, and EJP. United States Army Corps of Engineers cooperative agreement to KHW (# W912HZ-11-2-0023). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 38 TC 4 Z9 4 U1 1 U2 11 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JAN 12 PY 2016 VL 11 IS 1 AR e0146594 DI 10.1371/journal.pone.0146594 PG 26 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DA6CG UT WOS:000367888800017 PM 26756814 ER PT J AU Hu, Y Shaw, AP Guan, HR Norton, JR Sattler, W Rong, Y AF Hu, Yue Shaw, Anthony P. Guan, Hairong Norton, Jack R. Sattler, Wesley Rong, Yi TI Synthesis and Resolution of Chiral Ruthenium Complexes Containing the 1-Me-3-PhCp Ligand SO ORGANOMETALLICS LA English DT Article ID ASYMMETRIC TRANSFER HYDROGENATION; ARENE CHROMIUM COMPLEXES; C-H FUNCTIONALIZATION; ENANTIOMERICALLY PURE; ABSOLUTE-CONFIGURATION; CYCLOPENTADIENYLMETAL COMPLEXES; CRYSTALLOGRAPHIC DETERMINATION; PALLADIUM COMPLEXES; CRYSTAL-STRUCTURES; ANCHOR PHOSPHINE AB A new ruthenium chloride complex featuring chirality derived from the face-specific coordination of the 1-Me-3-PhCp ligand has been successfully synthesized and resolved. The resolution has been achieved via the diastereomers of the (5)-alpha-methylbenzenemethanethiolate complex (1-Me-3-PhCp)Ru(dppm){(S)-C(S)(H)(Ph)(Me)}. The X-ray structures of (S-Cp,S)-(1-Me-3-PhCp)Ru(dppm){C(S)(H)(Ph)(Me)} and (R-Cp,S)-(1-Me-3-PhCp)Ru(dppm){C(S)(H)(Ph)(Me)} have been determined. Racemization has been observed at elevated temperatures, but a room-temperature conversion pathway provides access to the corresponding enantiopure acetonitrile, chloride, and hydride complexes. C1 [Hu, Yue] Eastman Chem Co, Kingsport, TN 37662 USA. [Shaw, Anthony P.] US Army RDECOM ARDEC, Pyrotech Technol & Prototyping Div, Picatinny Arsenal, NJ 07806 USA. [Guan, Hairong] Univ Cincinnati, Dept Chem, Cincinnati, OH 45221 USA. [Norton, Jack R.; Rong, Yi] Columbia Univ, Dept Chem, New York, NY 10027 USA. [Sattler, Wesley] Dow Chem Co USA, Dow Elect Mat, Marlborough, MA 01752 USA. RP Norton, JR (reprint author), Columbia Univ, Dept Chem, New York, NY 10027 USA. EM jrn11@columbia.edu RI Guan, Hairong/I-1987-2013 OI Guan, Hairong/0000-0002-4858-3159 FU NSF [CHE-0749537]; Boulder Scientific; OFS Fitel FX This research was supported by NSF grant CHE-0749537, Boulder Scientific, and OFS Fitel. The National Science Foundation is thanked for acquisition of an X-ray diffractometer (CHE-0619638) and a 400 MHz NMR spectrometer (CHE-0840451). The authors are grateful to Prof. G. Parkin (Columbia University) for assistance with the X-ray structure determinations, and to Prof. J. Magyar (Barnard College) and Prof. J. Canary (NYU) for access to their circular dichroism spectrometers. NR 92 TC 0 Z9 0 U1 6 U2 19 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0276-7333 EI 1520-6041 J9 ORGANOMETALLICS JI Organometallics PD JAN 11 PY 2016 VL 35 IS 1 BP 39 EP 46 DI 10.1021/acs.organomet.5b00852 PG 8 WC Chemistry, Inorganic & Nuclear; Chemistry, Organic SC Chemistry GA DA8IJ UT WOS:000368048000008 ER PT J AU Madan, RA Donahue, RN Singh, H Karzai, F Theoret, MR Heery, CR Strauss, J Harold, N Couvillon, A Marte, JL Hankin, A Grenga, I Chun, G Rosner, IL McLeod, DG Cordes, LM Figg, WD Dahut, WL Schlom, J Gulley, JL AF Madan, Ravi Amrit Donahue, Renee Nicole Singh, Harpreet Karzai, Fatima Theoret, Marc Robert Heery, Christopher Ryan Strauss, Julius Harold, Nancy Couvillon, Anna Marte, Jennifer L. Hankin, Amy Grenga, Italia Chun, Guinevere Rosner, Inger L. McLeod, David G. Cordes, Lisa M. Figg, William Douglas Dahut, William L. Schlom, Jeffrey Gulley, James L. TI Clinical and immunologic impact of short course enzalutamide without androgen deprivation therapy for biochemically recurrent prostate cancer. SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract CT Genitourinary Cancers Symposium CY JAN 07-09, 2016 CL San Francisco, CA C1 NCI, NIH, Bethesda, MD 20892 USA. Ctr Canc Res, Lab Tumor Immunol & Biol, Bethesda, MD USA. NCI, Genitourinary Malignancies Branch, NIH, Bethesda, MD 20892 USA. NCI, Genitourinary Malignancies Branch, CCR, NIH, Bethesda, MD 20892 USA. NCI, Bethesda, MD 20892 USA. Walter Reed Natl Mil Med Ctr, Bethesda, MD USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NIH, Bldg 10, Bethesda, MD 20892 USA. NCI, Clin Pharmacol Program, NIH, Bethesda, MD 20892 USA. NCI, Lab Tumor Immunol & Biol, NIH, Bethesda, MD 20892 USA. RI Gulley, James/K-4139-2016; Figg Sr, William/M-2411-2016 OI Gulley, James/0000-0002-6569-2912; NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X EI 1527-7755 J9 J CLIN ONCOL JI J. Clin. Oncol. PD JAN 10 PY 2016 VL 34 IS 2 SU S MA 214 PG 1 WC Oncology SC Oncology GA DO9LW UT WOS:000378109100214 ER PT J AU Spring, MD Pichyangkul, S Lon, C Gosi, P Yongvanichit, K Srichairatanakul, U Limsalakpeth, A Chaisatit, C Chann, S Sriwichai, S Auayapon, M Chaorattanakawee, S Dutta, S Prom, S Chour, CM Walsh, DS Angov, E Saunders, DL AF Spring, Michele D. Pichyangkul, Sathit Lon, Chanthap Gosi, Panita Yongvanichit, Kosol Srichairatanakul, Utaiwan Limsalakpeth, Amporn Chaisatit, Chaiyaporn Chann, Soklyda Sriwichai, Sabaithip Auayapon, Montida Chaorattanakawee, Suwanna Dutta, Sheetij Prom, Satharath Chour, Char Meng Walsh, Douglas S. Angov, Evelina Saunders, David L. TI Antibody profiles to plasmodium merozoite surface protein-1 in Cambodian adults during an active surveillance cohort with nested treatment study SO MALARIA JOURNAL LA English DT Article DE Malaria; Antibodies; Merozoite surface protein 1; Biomarker; Chemoprophylaxis ID VACCINE CANDIDATE ANTIGEN; CLINICAL MALARIA; FALCIPARUM MALARIA; IMMUNE-RESPONSE; VIVAX RELAPSE; DOUBLE-BLIND; PROPHYLAXIS; MEFLOQUINE; TAFENOQUINE; PROTECTION AB Background: In addition to evidence for a protective role of antibodies to the malaria blood stage antigen merozoite surface protein 1 (MSP1), MSP1 antibodies are also considered as a marker of past malaria exposure in sero-epidemiological studies. Methods: In order to better assess the potential use of MSP1 serology in malaria chemoprophylaxis trials in endemic areas, an analysis for the prevalence of antibodies to both Plasmodium falciparum and Plasmodium vivax MSP1(42) in healthy Cambodian adults was conducted at two sites as part of an active, observational cohort evaluating the efficacy of dihydroartemisinin-piperaquine (DP) for uncomplicated malaria (ClinicalTrials.gov identifier NCT01280162). Results: Rates of baseline sero-positivity were high (59 and 73 % for PfMSP1(42) and PvMSP1(42), respectively), and titers higher in those who lived in a higher transmission area, although there was little correlation in titers between the two species. Those volunteers who subsequently went on to develop malaria had higher baseline MSP1(42) titers than those who did not for both species. Titers to both antigens remained largely stable over the course of the 4-6 month study, except in those infected with P. falciparum who had multiple recurrences. Conclusion: These findings illuminate the difficulties in using MSP1(42) serology as either a screening criterion and/or biomarker of exposure in chemoprophylaxis studies. Further work remains to identify useful markers of malarial infection and/or immunity. C1 [Spring, Michele D.; Pichyangkul, Sathit; Lon, Chanthap; Gosi, Panita; Yongvanichit, Kosol; Srichairatanakul, Utaiwan; Limsalakpeth, Amporn; Chaisatit, Chaiyaporn; Chann, Soklyda; Sriwichai, Sabaithip; Chaorattanakawee, Suwanna; Saunders, David L.] AFRIMS, Bangkok, Thailand. [Auayapon, Montida] Ctr Excellence Biomed & Publ Hlth Informat BIOPHI, Bangkok, Thailand. [Dutta, Sheetij; Angov, Evelina] Walter Reed Army Inst Res, Silver Spring, MD USA. [Prom, Satharath] Royal Cambodian Armed Forces, Phnom Penh, Cambodia. [Chour, Char Meng] Natl Ctr Parasitol Entomol & Malaria Control CNM, Phnom Penh, Cambodia. [Walsh, Douglas S.] SUNY Upstate Med Univ, Syracuse, NY 13210 USA. RP Lon, C (reprint author), AFRIMS, Bangkok, Thailand. EM chanthapl@afrims.org NR 40 TC 0 Z9 0 U1 0 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD JAN 8 PY 2016 VL 15 AR 17 DI 10.1186/s12936-015-1058-8 PG 10 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA DB3FW UT WOS:000368396700001 PM 26747132 ER PT J AU Borodin, O Olguin, M Ganesh, P Kent, PRC Allen, JL Henderson, WA AF Borodin, Oleg Olguin, Marco Ganesh, P. Kent, Paul R. C. Allen, Joshua L. Henderson, Wesley A. TI Competitive lithium solvation of linear and cyclic carbonates from quantum chemistry SO PHYSICAL CHEMISTRY CHEMICAL PHYSICS LA English DT Article ID LI-ION BATTERY; MOLECULAR-DYNAMICS SIMULATIONS; ORGANIC ELECTROLYTE-SOLUTIONS; POLARIZABLE FORCE-FIELDS; PC-EC SOLUTIONS; ETHYLENE CARBONATE; PROPYLENE CARBONATE; TRANSPORT-PROPERTIES; AB-INITIO; COMPUTATIONAL/SPECTROSCOPIC CHARACTERIZATION AB The composition of the lithium cation (Li+) solvation shell in mixed linear and cyclic carbonate-based electrolytes has been re-examined using Born Oppenheimer molecular dynamics (BOMD) as a function of salt concentration and cluster calculations with ethylene carbonate:dimethyl carbonate (EC:DMC)-LiPF6 as a model system. A coordination preference for EC over DMC to a Li+ was found at low salt concentrations, while a slightly higher preference for DMC over EC was found at high salt concentrations. Analysis of the relative binding energies of the (EC)(n)(DMC)(m) Li+ and (EC)(n)(DMC)(m)-LiPF6 solvates in the gas-phase and for an implicit solvent (as a function of the solvent dielectric constant) indicated that the DMC-containing Li+ solvates were stabilized relative to (EC4)-Li+ and (EC)(3)-LiPF6 by immersing them in the implicit solvent. Such stabilization was more pronounced in the implicit solvents with a high dielectric constant. Results from previous Raman and IR experiments were reanalyzed and reconciled by correcting them for changes of the Raman activities, IR intensities and band shifts for the solvents which occur upon Li+ coordination. After these correction factors were applied to the results of BOMD simulations, the composition of the Li+ solvation shell from the BOMD simulations was found to agree well with the solvation numbers extracted from Raman experiments. Finally, the mechanism of the Li+ diffusion in the dilute (EC:DMC)LiPF6 mixed solvent electrolyte was studied using the BOMD simulations. C1 [Borodin, Oleg; Olguin, Marco; Allen, Joshua L.] US Army, Electrochem Branch, RDRL SED C, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Ganesh, P.; Kent, Paul R. C.] Oak Ridge Natl Lab, Ctr Nanophase Mat Sci, 1 Bethel Valley Rd, Oak Ridge, TN 37831 USA. [Kent, Paul R. C.] Oak Ridge Natl Lab, Div Math & Comp Sci, 1 Bethel Valley Rd, Oak Ridge, TN 37831 USA. [Henderson, Wesley A.] Pacific NW Natl Lab, Electrochem Mat & Syst Grp, Energy & Environm Directorate, Richland, WA 99352 USA. RP Borodin, O (reprint author), US Army, Electrochem Branch, RDRL SED C, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM oleg.a.borodin.civ@mail.mil; ganeshp@ornl.gov RI Kent, Paul/A-6756-2008; OI Kent, Paul/0000-0001-5539-4017; Ganesh, Panchapakesan/0000-0002-7170-2902 FU Oak Ridge Associated Universities (ORAU) Postdoctoral Fellowship; Office of Science of the U.S. Department of Energy [DE-AC05-00OR22725]; U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences FX We thank Rang Xu and Arthur von Cresce for very stimulating discussions. QC calculations of solvates in implicit solvent and BOMD simulations of electrolytes were supported by the ARL Enterprise for Multiscale Research. M. O. was supported by an Oak Ridge Associated Universities (ORAU) Postdoctoral Fellowship. This research used resources of the Oak Ridge Leadership Computing Facility at the Oak Ridge National Laboratory, which is supported by the Office of Science of the U.S. Department of Energy under Contract No. DE-AC05-00OR22725. Plane wave calculations using VASP were supported as part of the Fluid Interface Reactions, Structures and Transport (FIRST) Center, an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences. NR 87 TC 11 Z9 11 U1 13 U2 38 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1463-9076 EI 1463-9084 J9 PHYS CHEM CHEM PHYS JI Phys. Chem. Chem. Phys. PD JAN 7 PY 2016 VL 18 IS 1 BP 164 EP 175 DI 10.1039/c5cp05121e PG 12 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA DB8GP UT WOS:000368755500017 PM 26601903 ER PT J AU Lesch, V Li, Z Bedrov, D Borodin, O Heuer, A AF Lesch, Volker Li, Zhe Bedrov, Dmitry Borodin, Oleg Heuer, Andreas TI The influence of cations on lithium ion coordination and transport in ionic liquid electrolytes: a MD simulation study SO PHYSICAL CHEMISTRY CHEMICAL PHYSICS LA English DT Article ID MOLECULAR-DYNAMICS SIMULATION; POLARIZABLE FORCE-FIELD; N-PROPYLPYRROLIDINIUM BIS(TRIFLUOROMETHANESULFONYL)IMIDE; SALT MIXTURES; PHYSICOCHEMICAL PROPERTIES; PYRROLIDINIUM CATIONS; POLYMER ELECTROLYTES; LIX MIXTURES; DOUBLE-LAYER; TFSI-ANIONS AB The dynamical and structural properties in two ionic liquid electrolytes (ILEs) based on 1-ethyl-3-methylimidazolium bis-(trifluoromethanesulfonyl)-imide ([emim][TFSI]) and N-methyl-N-propylpyrrolidinium bis-(trifluoromethanesulfonyl)imide([pyr(13)][TFSI]) were compared as a function of lithium bis(trifluoromethanesulfonyl)-imide (LiTFSI) salt concentrations using atomistic molecular dynamics (MD) simulations. The many-body polarizable APPLE&P force field has been utilized. The influence of anion polarization on the structure of the first coordination shell of Li+ was examined. In particular, the reduction of the oxygen of the TFSI anion (O-TFSI) polarizability from 1.36 angstrom(3) to 1.00 angstrom(3) resulted in an increased fraction of the TFSI anion bidentate coordination to the Li+. While the overall dynamics in [pyr(13)][TFSI]-based ILEs was slower than in [emim][TFSI]-based ILEs, the exchange of TFSI anions in and out of the first coordination shell of Li+ was found to be faster in pyr(13)-based systems. The Li+ ion transference number is higher for these systems as well. These trends can be related to the difference in interaction of TFSI with the IL cation which is stronger for pyr(13) than for emim. C1 [Lesch, Volker] Forschungszentrum Julich, Helmholtz Inst Munster, Inst Energie & Klimaforsch, Ion Energy Storage, Corrensstr 46, D-48149 Munster, Germany. [Lesch, Volker; Heuer, Andreas] Univ Munster, Inst Phys Chem, Corrensstr 28-30, D-48149 Munster, Germany. [Li, Zhe; Bedrov, Dmitry] Univ Utah, Dept Mat Sci & Engn, 122 South Cent Campus Dr,Room 304, Salt Lake City, UT 84112 USA. [Borodin, Oleg] US Army Res Lab, Electrochem Branch, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RP Lesch, V (reprint author), Forschungszentrum Julich, Helmholtz Inst Munster, Inst Energie & Klimaforsch, Ion Energy Storage, Corrensstr 46, D-48149 Munster, Germany.; Lesch, V (reprint author), Univ Munster, Inst Phys Chem, Corrensstr 28-30, D-48149 Munster, Germany. EM v.lesch@fr-juelich.de FU federal ministry of research and education [03X4631N]; Army Research Laboratory [W911NF-12-2-0023] FX We greatly acknowledge helpful discussions with Jens Smiatek, Christian Schroder, Jose Nuno Canongia Lopes and Diddo Diddens. V. L. and A. H. thank the federal ministry of research and education (Forderkennzeichen: 03X4631N) for financial support. D. B. and O. B. gratefully acknowledge the support from project sponsored by Army Research Laboratory under Cooperative Agreement Number W911NF-12-2-0023. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of ARL or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 94 TC 6 Z9 6 U1 6 U2 31 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1463-9076 EI 1463-9084 J9 PHYS CHEM CHEM PHYS JI Phys. Chem. Chem. Phys. PD JAN 7 PY 2016 VL 18 IS 1 BP 382 EP 392 DI 10.1039/c5cp05111h PG 11 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA DB8GP UT WOS:000368755500042 PM 26617256 ER PT J AU He, YD Qiao, R Vatamanu, J Borodin, O Bedrov, D Huang, JS Sumpter, BG AF He, Yadong Qiao, Rui Vatamanu, Jenel Borodin, Oleg Bedrov, Dmitry Huang, Jingsong Sumpter, Bobby G. TI Importance of Ion Packing on the Dynamics of Ionic Liquids during Micropore Charging SO JOURNAL OF PHYSICAL CHEMISTRY LETTERS LA English DT Article ID SUBNANOMETER PORES; FILLED NANOPORES; SLIT NANOPORE; CAPACITANCE; CARBON; SUPERCAPACITORS; SIMULATIONS; SIZE; ELECTRODES; STORAGE AB Molecular simulations of the diffusion of EMIM+ and TESI- ions in slit-shaped micropores under conditions similar to those during charging show that in pores that accommodate only a single layer of ions, ions diffuse increasingly faster as the pore becomes charged (with diffusion coefficients even reaching similar to 5 x 10(-9) m(2)/s), unless the pore becomes very highly charged. In pores wide enough to fit more than one layer of ions, ion diffusion is slower than in the bulk and changes modestly as the pore becomes charged. Analysis of these results revealed that the fast (or slow) diffusion of ions inside a micropore during charging is correlated most strongly with the dense (or loose) ion packing inside the pore. The molecular details of the ions and the precise width of the pores modify these trends weakly, except when the pore is so narrow that the ion conformation relaxation is strongly constrained by the pore walls. C1 [He, Yadong; Qiao, Rui] Virginia Tech, Dept Mech Engn, Blacksburg, VA 24061 USA. [Borodin, Oleg] US Army, Electrochem Branch, Res Lab, Adelphi, MD 20783 USA. [Vatamanu, Jenel; Bedrov, Dmitry] Univ Utah, Dept Mat Sci & Engn, Salt Lake City, UT 84112 USA. [Huang, Jingsong; Sumpter, Bobby G.] Oak Ridge Natl Lab, Ctr Nanophase Mat Sci, Oak Ridge, TN 37831 USA. [Huang, Jingsong; Sumpter, Bobby G.] Oak Ridge Natl Lab, Comp Sci & Math Div, Oak Ridge, TN 37831 USA. RP Qiao, R (reprint author), Virginia Tech, Dept Mech Engn, Blacksburg, VA 24061 USA. EM ruiqiao@vt.edu RI Sumpter, Bobby/C-9459-2013; Huang, Jingsong/A-2789-2008; Vatamanu, Jenel/I-7638-2012; Qiao, Rui/B-2350-2009 OI Sumpter, Bobby/0000-0001-6341-0355; Huang, Jingsong/0000-0001-8993-2506; Vatamanu, Jenel/0000-0003-0825-1608; Qiao, Rui/0000-0001-5219-5530 FU NSF [CBET-1461842]; University of Utah MRSEC (NSF grant) [DMR 11-21252] FX We thank the Clemson-CCIT and ARC at Virginia Tech for generous allocations of computer time on the Palmetto cluster and BlueRidge cluster. R.Q, acknowledges the support from NSF (CBET-1461842). R.Q, was partially supported by an appointment to the HERE program for faculty at the Oak Ridge National Laboratory (ORNL) administered by ORISE. D.B. and J.V. acknowledge the University of Utah MRSEC (NSF grant no. DMR 11-21252) for the support through the seed grant program. J.H. and B.G.S. acknowledge work performed at the Center for Nanophase Materials Sciences, a U.S. DOE Office of Science User Facility. NR 46 TC 8 Z9 8 U1 6 U2 26 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1948-7185 J9 J PHYS CHEM LETT JI J. Phys. Chem. Lett. PD JAN 7 PY 2016 VL 7 IS 1 BP 36 EP 42 DI 10.1021/acs.jpclett.5b02378 PG 7 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Atomic, Molecular & Chemical SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA DA7EZ UT WOS:000367968700007 PM 26641287 ER PT J AU Faria, M Garcia-Reyero, N Padros, F Babin, PJ Sebastian, D Cachot, J Prats, E Arick, M Rial, E Knoll-Gellida, A Mathieu, G Le Bihanic, F Escalon, BL Zorzano, A Soares, AMVM Raldua, D AF Faria, Melissa Garcia-Reyero, Natalia Padros, Francesc Babin, Patrick J. Sebastian, David Cachot, Jerome Prats, Eva Arick, Mark, II Rial, Eduardo Knoll-Gellida, Anja Mathieu, Guilaine Le Bihanic, Florane Escalon, B. Lynn Zorzano, Antonio Soares, Amadeu M. V. M. Raldua, Demetrio TI Zebrafish Models for Human Acute Organophosphorus Poisoning (vol 5, 15591, 2015) SO SCIENTIFIC REPORTS LA English DT Correction C1 [Arick, Mark, II] Mississippi State Univ, IGBB, Starkville, MS USA. [Escalon, B. Lynn] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA. RI Soares, Amadeu/A-8304-2008 OI Soares, Amadeu/0000-0003-0879-9470 NR 1 TC 0 Z9 0 U1 1 U2 6 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD JAN 7 PY 2016 VL 6 AR 17244 DI 10.1038/srep17244 PG 1 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DA9ZN UT WOS:000368168400002 PM 26738741 ER PT J AU Bates, ME Grieger, KD Trump, BD Keisler, JM Plourde, KJ Linkov, I AF Bates, Matthew E. Grieger, Khara D. Trump, Benjamin D. Keisler, Jeffrey M. Plourde, Kenton J. Linkov, Igor TI Emerging Technologies for Environmental Remediation: Integrating Data and Judgment SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID MULTICRITERIA DECISION-ANALYSIS; SYNTHETIC-BIOLOGY; RISK-ASSESSMENT; NANOMATERIALS; NZVI AB Emerging technologies present significant challenges to researchers, decision-makers, industry professionals, and other stakeholder groups due to the lack of quantitative risk, benefit, and cost data associated with their use. Multi-criteria decision analysis (MCDA) can support early decisions for emerging technologies when data is too sparse or uncertain for traditional risk assessment. It does this by integrating expert judgment with available quantitative and qualitative inputs across multiple criteria to provide relative technology scores. Here, an MCDA framework provides preliminary insights on the suitability of emerging technologies for environmental remediation by comparing nanotechnology and synthetic biology to conventional remediation methods. Subject matter experts provided judgments regarding the importance of criteria used in the evaluations and scored the technologies with respect to those criteria. The results indicate that synthetic biology may be preferred over nanotechnology and conventional methods for high expected benefits and low deployment costs but that conventional technology may be preferred over emerging technologies for reduced risks and development costs. In the absence of field data regarding the risks, benefits, and costs of emerging technologies, structuring evidence-based expert judgment through a weighted hierarchy of topical questions may be helpful to inform preliminary risk governance and guide emerging technology development and policy. C1 [Bates, Matthew E.; Linkov, Igor] US Army Corps Engineers, Engn Res & Dev Ctr, Environm Lab, Concord, MA 01742 USA. [Grieger, Khara D.] RTI Int, Res Triangle Pk, NC 27709 USA. [Trump, Benjamin D.] Univ Michigan, Sch Publ Hlth, Ann Arbor, MI 48109 USA. [Keisler, Jeffrey M.] Univ Massachusetts, Coll Management, Boston, MA 02125 USA. [Plourde, Kenton J.] US Army Corps Engineers, SOL Engn Serv, Concord, MA 01742 USA. RP Bates, ME (reprint author), US Army Corps Engineers, Engn Res & Dev Ctr, Environm Lab, 696 Virginia Rd, Concord, MA 01742 USA. EM Matthew.E.Bates@usace.army.mil; Igor.Linkov@usace.army.mil FU Engineer Research and Development Center of the U.S. Army Corps of Engineers; RTI International FX This study was funded by the Engineer Research and Development Center of the U.S. Army Corps of Engineers and by RTI International. It has been approved for publication by authority of the Chief of Engineers, U.S. Army Corps of Engineers. NR 34 TC 4 Z9 4 U1 5 U2 24 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD JAN 5 PY 2016 VL 50 IS 1 BP 349 EP 358 DI 10.1021/acs.est.5b03005 PG 10 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA DA5TU UT WOS:000367866300040 PM 26580228 ER PT J AU Naluyima, P Eller, LA Ouma, BJ Kyabaggu, D Kataaha, P Guwatudde, D Kibuuka, H Wabwire-Mangen, F Robb, ML Michael, NL de Souza, MS Sandberg, JK Eller, MA AF Naluyima, Prossy Eller, Leigh Anne Ouma, Benson J. Kyabaggu, Denis Kataaha, Peter Guwatudde, David Kibuuka, Hannah Wabwire-Mangen, Fred Robb, Merlin L. Michael, Nelson L. de Souza, Mark S. Sandberg, Johan K. Eller, Michael A. TI Sex and Urbanicity Contribute to Variation in Lymphocyte Distribution across Ugandan Populations SO PLOS ONE LA English DT Article ID REFERENCE INTERVALS; IMMUNE-RESPONSES; HEALTHY UGANDANS; REFERENCE VALUES; REFERENCE RANGES; VACCINE; TRIALS; ADULTS; EOSINOPHILS; INFECTION AB Management of patient care and interpretation of research data require evaluation of laboratory results in the context of reference data from populations with known health status to adequately diagnose disease or make a physiological assessment. Few studies have addressed the diversity of lymphocyte subsets in rural and urban Ugandan populations. Here, 663 healthy blood bank donors from semi-urban centers of Kampala consented to participate in a study to define lymphocyte reference ranges. Whole blood immunophenotyping was performed to determine the frequency and absolute counts of T, B, and NK cells using clinical flow cytometry. Results from blood bank donors were compared to a rural cohort from the district of Kayunga and more urban clinical trial participants from the capital city, Kampala. Relationships between hematological and lymphocyte parameters were also explored. In the semi-urban blood donors, females were significantly different from males in all parameters except the frequency of CD8 T and B cells. Females had higher absolute counts of CD4 T, CD8 T and B cells, whereas males had higher NK cell counts. NK cell frequency and counts were significantly higher in semi-urban blood donors, regardless of sex, compared to more urban study participants. CD8 T cell frequency and counts were significantly higher in the blood donors compared to the rural participants, irrespective of sex. Interestingly, basophil counts were positively associated with overall T cell counts. These findings suggest that both sex and level of cohort urbanicity may influence lymphocyte subset distributions in Ugandans. C1 [Naluyima, Prossy; Ouma, Benson J.; Kyabaggu, Denis; Kibuuka, Hannah; Wabwire-Mangen, Fred] Makerere Univ, Walter Reed Project, Kampala, Uganda. [Naluyima, Prossy; Sandberg, Johan K.] Karolinska Univ, Huddinge Hosp, Karolinska Inst, Ctr Infect Med,Dept Med, Stockholm, Sweden. [Eller, Leigh Anne; Robb, Merlin L.; Michael, Nelson L.; Eller, Michael A.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 21218 USA. [Eller, Leigh Anne; Robb, Merlin L.; Eller, Michael A.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Kataaha, Peter] Uganda Natl Blood Transfus Serv, Kampala, Uganda. [Guwatudde, David; Wabwire-Mangen, Fred] Makerere Univ, Sch Publ Hlth, Coll Hlth Sci, Kampala, Uganda. [de Souza, Mark S.] Thai Red Cross AIDS Res Ctr, SEARCH, Bangkok, Thailand. RP Eller, MA (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 21218 USA. EM meller@hivresearch.org OI Sandberg, Johan/0000-0002-6275-0750 FU Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-11-2-0174]; U.S. Department of Defense (DoD) [W81XWH-11-2-0174]; Swedish Research Council; Swedish Cancer Society; Stockholm County Council; Karolinska Institutet; Division of Intramural Research, NIAID, NIH FX This work was supported by a cooperative agreement (W81XWH-11-2-0174) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense (DoD). Additional support was provided by the Swedish Research Council, the Swedish Cancer Society, the Stockholm County Council, Karolinska Institutet, and the Division of Intramural Research, NIAID, NIH. NR 42 TC 0 Z9 0 U1 1 U2 1 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JAN 5 PY 2016 VL 11 IS 1 AR e0146196 DI 10.1371/journal.pone.0146196 PG 16 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DA4VZ UT WOS:000367801400114 PM 26730706 ER PT J AU Crawford, P Thai, C Obholz, J Schievenin, J True, M Shah, SA Hallgren, J Clark, J Sharon, D AF Crawford, Paul Thai, Chuong Obholz, Joshua Schievenin, Jeffrey True, Mark Shah, Sachin A. Hallgren, John Clark, Jill Sharon, Danny TI Assessment of the effeCt of lIfestyle iNtervention plus water-soluble ciNnAMon extract On loweriNg blood glucose in pre-diabetics, a randomized, double-blind, multicenter, placebo controlled trial: study protocol for a randomized controlled trial SO TRIALS LA English DT Article DE Diabetes; Cinnamon; Prevention; Pre-diabetes; Protocol; Cinnulin PF; Cinnamon extract; Impaired glucose tolerance ID ALTERNATIVE MEDICINE; TYPE-2; COMPLEMENTARY; MELLITUS; A1C; PEOPLE; LIPIDS AB Background: The World Health Organization predicts that by 2030 diabetes will be the seventh leading cause of death in the world. Multiple studies have tried to determine if cinnamon is an effective treatment for diabetes. Cinnamon extract is an insulin sensitizer, protects mesangial cells, decreases inflammatory markers, and lowers glucose, lipids, and blood pressure in patients with type 2 diabetes, so we developed a protocol to study whether ingestion of water-soluble cinnamon extract prevents progression from pre-diabetes to diabetes. Methods/design: This is a randomized, double-blind, placebo-controlled trial comparing cinnamon extract versus placebo in subjects with pre-diabetes who have committed to participate in a lifestyle change program. The trial will be conducted at five sites and will include 428 subjects who take cinnamon extract or placebo for 1 year. Follow-up for these subjects will be for a total of 2 years (nine study visits). The primary outcomes to be assessed are 1) conversion of patients from pre-diabetes to diabetes and 2) impact of water-soluble cinnamon extract on hepatic transaminases, renal function, and QT interval on electrocardiogram. Secondary outcomes include changes in HbA1c, lipids, waist circumference, weight, blood pressure, and fasting plasma glucose. The trial protocol has been approved by the Institutional Review Board of the US Air Force 59th Medical Wing, Wilford Hall Ambulatory Surgical Center (Protocol FWH20110035H). Investigator-sponsored Investigational New Drug status (114078) was granted by the US Food and Drug Administration. Discussion: This study will provide high-quality evidence of the efficacy of water-soluble cinnamon extract in conjunction with lifestyle intervention for preventing patients with pre-diabetes from converting to diabetes. Additionally, it will provide important safety information about water-soluble cinnamon extract. C1 [Crawford, Paul] Nellis Family Med Residency, Las Vegas, NV 89191 USA. [Thai, Chuong; Obholz, Joshua; Schievenin, Jeffrey] Eglin AFB Family Med Residency, Eglin AFB, FL 32542 USA. [True, Mark] Brooke Army Med Ctr, Air Force Endocrinol Fellowship, Jbsa Ft Sam Houston, TX 78234 USA. [Shah, Sachin A.] Univ Pacific, Pharm Practice, Vacaville, CA USA. [Hallgren, John] 55MDOS, Offutt AFB, NE 68113 USA. [Clark, Jill] Nellis Clin Invest Program, Las Vegas, NV 89191 USA. [Sharon, Danny] Adolos Strateg, San Antonio, TX USA. RP Crawford, P (reprint author), Nellis Family Med Residency, 4700 Las Vegas Blvd N, Las Vegas, NV 89191 USA. EM paul.crawford@us.af.mil FU US Air Force Medical Support Agency (AFMSA) SG9 Operational Medicine Branch, Fuchsia Program Diabetes Funding program; US Air Force 59th Medical Wing Science and Technology Section; 99th Medical Group; Integrity Nutraceuticals (Spring Hill, TN) FX Funding for this trial was provided 1) by US Air Force Medical Support Agency (AFMSA) SG9 Operational Medicine Branch, Fuchsia Program Diabetes Funding program in 2011; 2) by the US Air Force 59th Medical Wing Science and Technology Section in 2014; 3) through a Cooperative Research and Development Agreement between the 99th Medical Group and Integrity Nutraceuticals (Spring Hill, TN) whereby Integrity provided Cinnulin PF and placebo for free; and 4) through intramural support from each participating hospital. NR 28 TC 0 Z9 0 U1 4 U2 8 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1745-6215 J9 TRIALS JI Trials PD JAN 5 PY 2016 VL 17 AR 9 DI 10.1186/s13063-015-1138-7 PG 6 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA DA4UJ UT WOS:000367796400005 PM 26732017 ER PT J AU Henry, NC Brown, A Knorr, DB Baril, N Nallon, E Lenhart, JL Tidrow, M Bandara, S AF Henry, Nathan C. Brown, Alexander Knorr, Daniel B. Baril, Neil Nallon, Eric Lenhart, Joseph L. Tidrow, Meimei Bandara, Sumith TI Surface conductivity of InAs/GaSb superlattice infrared detectors treated with thiolated self assembled monolayers SO APPLIED PHYSICS LETTERS LA English DT Article ID MOBILITY-SPECTRUM ANALYSIS; INAS SURFACES; ACCUMULATION; PASSIVATION; WAVELENGTH AB The surface conductivity of InAs/GaSb based type II superlattice (T2SL) long wavelength infrared material following the deposition of thiolated self-assembled monolayers (SAMs) of cysteamine, octadecanethiol, dodecanethiol, and hexanethiol are reported. Quantitative mobility spectrum analysis (QMSA) was employed to study the mobility and to isolate and identify surface carriers following SAM treatments on planar samples. QMSA data collected following the deposition of the SAMs on InAs/GaSb material correlates well with dark current measurements, demonstrating the usefulness of QMSA as a tool for evaluating surface conductivity and predicting device performance. All samples displayed a reduction in surface conductivity and dark current density following thiol treatment. Dark current densities were reduced to 1.1 x 10(-5), 1.3 x 10(-5), 1.6 x 10(-5), and 5 x 10(-6) A/cm(2) for hexanethiol, dodecanethiol, octadecanethiol, and cysteamine, respectively, from 5.7 x 10(-4) A cm(2) for unpassivated devices. (C) 2016 AIP Publishing LLC. C1 [Henry, Nathan C.; Brown, Alexander] Fulcrum Co, Centreville, VA 20120 USA. [Henry, Nathan C.; Brown, Alexander; Baril, Neil; Nallon, Eric; Tidrow, Meimei; Bandara, Sumith] US Army, RDECOM CERDEC NVESD, Ft Belvoir, VA 22060 USA. [Knorr, Daniel B.; Lenhart, Joseph L.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Henry, NC (reprint author), US Army, RDECOM CERDEC NVESD, Ft Belvoir, VA 22060 USA.; Henry, NC (reprint author), 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA. EM info@nvl.army.mil OI Henry, Nathan/0000-0002-7033-8467 NR 23 TC 0 Z9 0 U1 5 U2 11 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JAN 4 PY 2016 VL 108 IS 1 AR 011606 DI 10.1063/1.4938168 PG 4 WC Physics, Applied SC Physics GA DJ6HU UT WOS:000374313000018 ER PT J AU Modjarrad, K Giersing, B Kaslow, DC Smith, PG Moorthy, VS AF Modjarrad, Kayvon Giersing, Birgitte Kaslow, David C. Smith, Peter G. Moorthy, Vasee S. CA WHO RSV Vaccine Consultation TI WHO consultation on Respiratory Syncytial Virus Vaccine Development Report from a World Health Organization Meeting held on 23-24 March 2015 SO VACCINE LA English DT Article DE Respiratory syncytial virus; Vaccine; Clinical development ID NANOPARTICLE VACCINE; RSV VACCINE; INFECTION; INFANTS; CHILDREN; IMMUNIZATION; DISEASE; LIVE; IMMUNOGENICITY; ANTIBODIES AB Respiratory syncytial virus (RSV) is a globally prevalent cause of lower respiratory infection in neonates and infants. Despite its disease burden, a safe and effective RSV vaccine has remained elusive. In recent years, improved understanding of RSV biology and innovations in immunogen design has resulted in the advancement of multiple vaccine candidates into the clinical development pipeline. Given the growing number of vaccines in clinical trials, the rapid pace at which they are being tested, and the likelihood that an RSV vaccine will reach the commercial market in the next 5-10 years, consensus and guidance on clinical development pathways and licensure routes are needed now, before large-scale efficacy trials commence. In pursuit of this aim, the World Health Organization convened the first RSV vaccine consultation in 15 years on the 23rd and 24th of March, 2015 in Geneva, Switzerland. The meeting's primary objective was to provide guidance on clinical endpoints and development pathways for vaccine trials with a focus on considerations of low- and middle-income countries. Meeting participants reached consensus on candidate case definitions for RSV disease, considerations for clinical efficacy endpoints, and the clinical development pathway for active and passive immunization trials in maternal and pediatric populations. The strategic focus of this meeting was on the development of high quality, safe and efficacious RSV preventive interventions for global use and included; (1) maternal/passive immunization to prevent RSV disease in infants less than 6 months; (2) pediatric immunization to prevent RSV disease in infants and young children once protection afforded by maternal immunization wanes. (C) 2015 World Health Organization; licensee Elsevier. Published by Elsevier Ltd. All rights reserved. C1 [Modjarrad, Kayvon; Giersing, Birgitte; Moorthy, Vasee S.] WHO, Initiat Vaccine Res, CH-1211 Geneva 27, Switzerland. [Modjarrad, Kayvon] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. [Kaslow, David C.] PATH, Seattle, WA 98109 USA. [Smith, Peter G.] Univ London London Sch Hyg & Trop Med, London WC1E 7HT, England. RP Moorthy, VS (reprint author), WHO, Initiat Vaccine Res, CH-1211 Geneva 27, Switzerland. EM moorthyv@who.int RI Nair, Harish/E-7431-2010 OI Nair, Harish/0000-0002-9432-9100 FU Bill & Melinda Gates Foundation FX We acknowledge the preparatory analysis of endpoints and case definitions used in previous RSV preventive intervention trials developed by Prof. Eric Simoes of the University of Colorado Health Sciences Center, Denver, Colorado, USA. Fig. 1 is adapted from the PATH RSV Vaccine Snapshot. We acknowledge the technical input into the preparation for the consultation by the following individuals: Professor Barney Graham of Vaccine Research Center, NIAID, Bethesda, MD, USA; Professor Ruth Karron of Center for Immunization Research, Johns Hopkins University, Baltimore, MD, USA and Dr Jeff Roberts, US Food and Drug Administration, Center for Biologics Evaluation and Research, Silver Spring, MD, USA. WHO's RSV vaccine acitivities are guided by a Technical Advisory Group consisting of Prof. Narendra Arora, the INCLEN Trust International, New Delhi, India; Dr Mair Powell, Medicines and Healthcare Products Regulatory Agency, London, UK; Prof. Helen Rees, Wits Reproductive Health and HIV Institute, Johannesburg, South Africa and Prof. Peter Smith, London School of Hygiene and Tropical Medicine, London, UK. We gratefully acknowledge funding from the Bill & Melinda Gates Foundation to support the consultation reported here. NR 40 TC 19 Z9 19 U1 4 U2 8 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD JAN 4 PY 2016 VL 34 IS 2 BP 190 EP 197 DI 10.1016/j.vaccine.2015.05.093 PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA DB0RD UT WOS:000368214300002 PM 26100926 ER PT J AU Teegavarapu, RSV Pathak, CS Mecikalski, JR Srikishen, J AF Teegavarapu, Ramesh S. V. Pathak, Chandra S. Mecikalski, John R. Srikishen, Jayanthi TI Optimal solar radiation sensor network design using spatial and geostatistical analyses SO JOURNAL OF SPATIAL SCIENCE LA English DT Review DE geostatistics; standard error; optimal sensor network; geospatial analysis; evapotranspiration; solar radiation ID SURFACE INSOLATION; SATELLITE DATA; POTENTIAL EVAPOTRANSPIRATION; SAMPLING DESIGN; METEOSAT DATA; MODEL; IRRADIANCE; CLIMATOLOGY; EVAPORATION; WATER AB A methodology for optimal ground-based sensor network design for an evapotranspiration (ET) estimation method which uses solar radiation as the only parameter is developed and evaluated in this study. The methodology employs geospatial analyses and a geostatistical approach, and data from ground-based sensors and satellite-based estimates of solar insolation (i.e. total amount of solar radiation energy received on a given surface area during a given time) considering the spatial variability of the data. The applicability of the methodology is demonstrated by using Geostationary Operational Environmental Satellite (GOES)-estimated and 29 ground sensor-based observed solar insolation data in the South Florida region of the USA. Results indicate that the optimal design of network depends on the spatial variability of insolation, analysis block size defined based on region-specific radiation characteristics, and the standard error used as a metric of network estimation accuracy. C1 [Teegavarapu, Ramesh S. V.] Florida Atlantic Univ, Dept Civil Engn, Boca Raton, FL 33431 USA. [Pathak, Chandra S.] US Army, Corps Engineers, Hydrol Hydraul & Coastal Community Practice, Washington, DC 20310 USA. [Mecikalski, John R.] Univ Alabama, Dept Atmospher Sci, 320 Sparkmen Dr, Huntsville, AL 35899 USA. [Srikishen, Jayanthi] NASA, George C Marshall Space Flight Ctr, Univ Space Res Assoc, 320 Sparkman Dr, Huntsville, AL 35812 USA. RP Teegavarapu, RSV (reprint author), Florida Atlantic Univ, Dept Civil Engn, Boca Raton, FL 33431 USA. EM rteegava@fau.edu FU South Florida Water Management District (SFWMD), Florida, USA FX The authors sincerely thank the three anonymous reviewers and the associate editor for providing several constructive comments that have led to substantial improvement of the manuscript. The study reported in the paper was supported by South Florida Water Management District (SFWMD), Florida, USA. NR 68 TC 0 Z9 0 U1 3 U2 3 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1449-8596 EI 1836-5655 J9 J SPAT SCI JI J. Spat. Sci. PD JAN 2 PY 2016 VL 61 IS 1 BP 69 EP 97 DI 10.1080/14498596.2015.1051147 PG 29 WC Geography, Physical; Remote Sensing SC Physical Geography; Remote Sensing GA DI9PQ UT WOS:000373835300002 ER PT J AU Garneau, CJ Parkinson, MB AF Garneau, Christopher J. Parkinson, Matthew B. TI A survey of anthropometry and physical accommodation in ergonomics curricula SO ERGONOMICS LA English DT Article DE Ergonomics tools and methods; anthropometry; ergonomics education; physical ergonomics ID DESIGN AB The size and shape of users are an important consideration for many products and environments. Designers and engineers in many disciplines must often accommodate these attributes to meet objectives such as fit and safety. When practitioners have academic training in addressing these issues, it is typically through courses in Human Factors/Ergonomics (HF/E). This paper investigates education related to physical accommodation and offers suggestions for improvement. A survey was conducted wherein 21 instructors at 18 universities in the United States provided syllabi for 29 courses, which were analysed to determine topics related to anthropometry and resources used for the courses. The results show that within the US, anthropometry is covered in the majority of courses discussing physical ergonomics, but important related concepts were often omitted (e.g. digital human modelling, multivariate accommodation and variability across global populations). Curricula could be improved by incorporating more accurate anthropometry, multivariate problems and interactive online tools. Practitioner Summary: This paper describes a study investigating collegiate ergonomics courses within the US in the area of physical accommodation. Course schedules and texts were studied for their treatment of several topics related to accommodating the spatial requirements (anthropometry) of users. Recommendations are made for improving course curricula. C1 [Parkinson, Matthew B.] Penn State Univ, Engn Design Mech Engn & Ind Engn, University Pk, PA 16802 USA. [Garneau, Christopher J.] US Army, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD USA. RP Garneau, CJ (reprint author), US Army, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD USA. EM christopher.j.garneau.civ@mail.mil NR 44 TC 0 Z9 0 U1 1 U2 3 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0014-0139 EI 1366-5847 J9 ERGONOMICS JI Ergonomics PD JAN 2 PY 2016 VL 59 IS 1 BP 143 EP 154 DI 10.1080/00140139.2015.1052853 PG 12 WC Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology SC Engineering; Psychology GA DG4KE UT WOS:000372040300013 PM 26849430 ER PT J AU Bot, A Bailey, C Brumeanu, T Casares, S Kuppuswamy, K Zaghouani, H AF Bot, Adrian Bailey, Celeste Brumeanu, Teodor Casares, Sofia Kuppuswamy, Kasturi Zaghouani, Habib TI Constantin A. Bona, M.D., Ph.D. OBITUARY SO INTERNATIONAL REVIEWS OF IMMUNOLOGY LA English DT Biographical-Item C1 [Bot, Adrian] Kite Pharma Inc, Int Reviews Immunol, 2225 Colorado Ave, Santa Monica, CA 90404 USA. [Bot, Adrian] Kite Pharma Inc, Translat Sci, 2225 Colorado Ave, Santa Monica, CA 90404 USA. [Bailey, Celeste] AMCR Inst, Escondido, CA USA. [Bailey, Celeste] Natl Univ, San Diego, CA USA. [Brumeanu, Teodor] Uniformed Serv Univ Hlth Sci, Dept Med Mol & Cell Biol, Bethesda, MD 20814 USA. [Casares, Sofia] Walter Reed Army Inst Res, US Mil Malaria Vaccine Program, Preclin Res, Naval Med Res Center, Silver Spring, MD USA. [Kuppuswamy, Kasturi] US FDA, US Dept HHS, Washington, DC 20204 USA. [Zaghouani, Habib] Univ Missouri, Mol Microbiol & Immunol, Columbia, MO USA. RP Bot, A (reprint author), Kite Pharma Inc, Int Reviews Immunol, 2225 Colorado Ave, Santa Monica, CA 90404 USA.; Bot, A (reprint author), Kite Pharma Inc, Translat Sci, 2225 Colorado Ave, Santa Monica, CA 90404 USA. EM abot@kitepharma.com NR 1 TC 0 Z9 0 U1 0 U2 0 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 0883-0185 EI 1563-5244 J9 INT REV IMMUNOL JI Int. Rev. Immunol. PD JAN 2 PY 2016 VL 35 IS 1 BP 1 EP 3 DI 10.3109/08830185.2016.1139991 PG 3 WC Immunology SC Immunology GA DG5EN UT WOS:000372098300001 PM 26959800 ER PT J AU Harris, C Milton, DJ AF Harris, Cameron Milton, Daniel James TI Is Standing for Women a Stand Against Terrorism? Exploring the Connection Between Women's Rights and Terrorism SO JOURNAL OF HUMAN RIGHTS LA English DT Article ID TRANSNATIONAL TERRORISM; GENDER INEQUALITY; INTERNAL CONFLICT; FEMALE TERRORISM; CHILD WITNESSES; VETO PLAYERS; CIVIL-WAR; VIOLENCE; DEMOCRACY; EQUALITY AB Previous large-N studies have found that the advancement of women's rights leads to a decline in conflict, but no large-N research has explored the possibility of a similar relationship between women's rights and terrorism. Nevertheless, policymakers have long argued that the advancement of women's rights forms a key component of counterterrorism policy. Simply put, we lay out a rationale for the argument that increased women's rights reduce the likelihood of terrorism. We test this hypothesis using CIRI's women's rights data combined with two datasets accounting for domestic terrorism and the production of transnational terrorism. While the results show that women's rights overall are not a panacea for both types of terrorism, the provision of women's rights is shown to have a negative relationship with domestic terrorism. States and international institutions should take the differing effects of women's rights across different types of terrorism into account when designing counterterrorism policies. C1 [Harris, Cameron] Georgetown Univ, Secur Studies, Washington, DC 20057 USA. [Milton, Daniel James] US Mil Acad, Dept Social Sci, West Point, NY 10996 USA. RP Milton, DJ (reprint author), US Mil Acad, Combating Terrorism Ctr, 607 Cullum Rd, West Point, NY 10996 USA. EM Daniel.Milton@usma.edu NR 69 TC 0 Z9 0 U1 8 U2 18 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1475-4835 EI 1475-4843 J9 J HUM RIGHTS JI J. Hum. Rights PD JAN 2 PY 2016 VL 15 IS 1 BP 60 EP 78 DI 10.1080/14754835.2015.1062722 PG 19 WC International Relations; Political Science SC International Relations; Government & Law GA DE0BW UT WOS:000370290700004 ER PT J AU Perkins, MW Wong, B Rodriguez, A Devorak, JL Dao, TT Leuschner, JA Kan, RK Sciuto, AM AF Perkins, Michael W. Wong, Benjamin Rodriguez, Ashley Devorak, Jennifer L. Dao, Thuy T. Leuschner, Jessica A. Kan, Robert K. Sciuto, Alfred M. TI Vapor inhalation exposure to soman in conscious untreated rats: preliminary assessment of neurotoxicity SO INHALATION TOXICOLOGY LA English DT Article DE Chemical warfare nerve agents; cholinesterases; inhalation exposure; neurotoxicity; soman ID STATUS EPILEPTICUS; INDUCED SEIZURES; NERVE AGENTS; BRAIN; ACETYLCHOLINESTERASE; NEUROPATHOLOGY; SPECIFICITY; MECHANISMS; SARIN AB Neurological toxicity and brain injury following vapor inhalation exposure to the chemical warfare nerve agent (CWNA) soman (GD) were examined in untreated non-anesthetized rats. In this study, male Sprague-Dawley rats (300-350g) were exposed to 600mgxmin/m(3) of soman or vehicle in a customized head-out inhalation system for 7min. Convulsant animals were observed for clinical signs and various regions of the brain (dorsolateral thalamus, basolateral amygdala, piriform cortex, and lateral cortex) were collected for pathological observations 24h post-exposure. Signs of CWNA-induced cholinergic crises including salivation, lacrimation, increased urination and defecation, and tremors were observed in all soman-exposed animals. Soman-exposed animals at 24h post-exposure lost 11% of their body weight in comparison to 2% in vehicle-exposed animals. Whole blood acetylcholinesterase (AChE) activity was significantly inhibited in all soman-exposed groups in comparison to controls. Brain injury was confirmed by the neurological assessment of hematoxylin-eosin (H&E) staining and microscopy in the piriform cortex, dorsolateral thalamus, basolateral amygdala, and lateral cortex. Severe damage including prominent lesions, edematous, congested, and/or hemorrhagic tissues was observed in the piriform cortex, dorsolateral thalamus, and lateral cortex in soman-exposed animals 24h post-exposure, while only minimal damage was observed in the basolateral amygdala. These results indicate that inhalation exposure to soman vapor causes neurological toxicity and brain injury in untreated unanesthetized rats. This study demonstrates the ability of the described soman vapor inhalation exposure model to cause neurological damage 24h post-exposure in rats. C1 [Perkins, Michael W.; Wong, Benjamin; Rodriguez, Ashley; Devorak, Jennifer L.; Dao, Thuy T.; Leuschner, Jessica A.; Kan, Robert K.; Sciuto, Alfred M.] US Army, Med Res Inst Chem Def, Analyt Toxicol Branch, Aberdeen Proving Ground, MD 21010 USA. RP Perkins, MW (reprint author), US Army, Med Res Inst Chem Def, Analyt Toxicol Div, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM michael.w.perkins1.civ@mail.mil FU Oak Ridge Associated Universities FX Special thanks to the Comparative Pathology Branch for providing outstanding pathology support. AR and JL are supported by the Oak Ridge Associated Universities. The experimental protocol was approved by the Animal Care and Use Committee at the United States Army Medical Research Institute of Chemical Defense and all procedures were conducted in accordance with the principles stated in the Guide for the Care and Use of Laboratory Animals and the Animal Welfare Act of 1966 (P.L. 89-544), as amended. The views expressed in this article are those of the author(s) and do not reflect the official policy of the Department of Army, Department of Defense, or the U.S. Government. NR 37 TC 1 Z9 1 U1 0 U2 4 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0895-8378 EI 1091-7691 J9 INHAL TOXICOL JI Inhal. Toxicol. PD JAN 2 PY 2016 VL 28 IS 1 BP 14 EP 21 DI 10.3109/08958378.2015.1125973 PG 8 WC Toxicology SC Toxicology GA DD3VM UT WOS:000369851200003 PM 26711353 ER PT J AU Jain, RB Choi, YS AF Jain, Ram B. Choi, Y. Sammy TI Interacting effects of selected trace and toxic metals on thyroid function SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH LA English DT Article DE manganese; iron; copper; zinc; cadmium; lead; mercury; selenium; thyroid ID NUTRITION EXAMINATION SURVEY; CAFFEINE CONSUMPTION; NATIONAL-HEALTH; HORMONE LEVELS; UNITED-STATES; MANGANESE; ZINC; POPULATION; SELENIUM; ASSOCIATION AB Interacting effects of blood levels of manganese (Mn), selenium, cadmium (Cd), lead (Pb), and mercury, and serum levels of iron (Fe), zinc (Zn), and copper (Cu) on thyroid function in general US population were evaluated. Data from the National Health and Nutrition Examination Survey for 2011-2012 were used for this evaluation. The variables used to evaluate thyroid function were as follows: thyroid-stimulating hormone, free and total triiodothyronine (FT3, TT3), free and total thyroxine (FT4, TT4), and thyroglobulin (Tg). Levels of FT4 were positively associated with the levels of copper and negatively associated with the levels of Fe for males only. Elevated levels of Mn and Fe were associated with increased levels of FT3 for both males and females. TT4 had a positive association with the levels of Cu and a negative association with the levels of Fe for both males and females. C1 [Jain, Ram B.; Choi, Y. Sammy] Womack Army Med Ctr, Dept Clin Invest, Ft Bragg, NC USA. [Jain, Ram B.] Empiristat Inc, Mt Airy, MD USA. RP Jain, RB (reprint author), Womack Army Med Ctr, Dept Clin Invest, Ft Bragg, NC USA. EM ram.b.jain.ctr@mail.mil NR 34 TC 1 Z9 1 U1 1 U2 9 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND SN 0960-3123 EI 1369-1619 J9 INT J ENVIRON HEAL R JI Int. J. Environ. Health Res. PD JAN 2 PY 2016 VL 26 IS 1 BP 75 EP 91 DI 10.1080/09603123.2015.1020416 PG 17 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA DB9CF UT WOS:000368813000005 PM 25788177 ER PT J AU Gerhardt, RT Reeves, PT Kotwal, RS Mabry, RL Robinson, JB Butler, F AF Gerhardt, Robert T. Reeves, Patrick T. Kotwal, Russ S. Mabry, Robert L. Robinson, John B. Butler, Frank TI ANALYSIS OF PREHOSPITAL DOCUMENTATION OF INJURY-RELATED PAIN ASSESSMENT AND ANALGESIC ADMINISTRATION ON THE CONTEMPORARY BATTLEFIELD SO PREHOSPITAL EMERGENCY CARE LA English DT Article DE emergency medical services; war; pain-therapy; military medicine; analgesic agents ID COMBAT CASUALTY CARE; POSTTRAUMATIC-STRESS-DISORDER; THEATER TRAUMA REGISTRY; MORPHINE; KETAMINE; MANAGEMENT; FENTANYL; SAFETY; IRAQ AB In addition to life-saving interventions, the assessment of pain and subsequent administration of analgesia are primary benchmarks for quality emergency medical services care which should be documented and analyzed. Analyze US combat casualty data from the Department of Defense Trauma Registry (DoDTR) with a primary focus on prehospital pain assessment, analgesic administration and documentation. Retrospective cohort study of battlefield prehospital and hospital casualty data were abstracted by DoDTR from available records from 1 September 2007 through 30 June 2011. Data included demographics; injury mechanism; prehospital and initial combat hospital pain assessment documented by standard 0-to-10 numeric rating scale; analgesics administered; and survival outcome. Records were available for 8,913 casualties (median ISS of 5 [IQR 2 to 10]; 98.7% survived). Prehospital analgesic administration was documented for 1,313 cases (15%). Prehospital pain assessment was recorded for 581 cases (7%; median pain score 6 [IQR 3 to 8]), hospital pain assessment was recorded for 5,007 cases (56%; median pain score5 [CI95% 3 to 8]), and 409 cases (5%) had both prehospital and hospital pain assessments that could be paired. In this paired group, 49.1% (201/409) had alleviation of pain evidenced by a decrease in pain score (median 4,, IQR 2 to 5); 23.5% (96/409) had worsening of pain evidenced by an increase in pain score (median 3, CI95 2.8 to 3.7, IQR 1 to 5); 27.4% (112/409) had no change; and the overall difference was an average decrease in pain score of 1.1 (median 0, IQR 0 to 3, p < 0.01). Time-series analysis showed modest increases in prehospital and hospital pain assessment documentation and prehospital analgesic documentation. Our study demonstrates that prehospital pain assessment, management, and documentation remain primary targets for performance improvement on the battlefield. Results of paired prehospital to hospital pain scores and time-series analysis demonstrate both feasibility and benefit of prehospital analgesics. Future efforts must also include an expansion of the prehospital battlefield analgesic formulary. C1 [Gerhardt, Robert T.] Brooke Army Med Ctr, Emergency Med, San Antonio, TX 78234 USA. [Reeves, Patrick T.] Univ Texas Med Branch, Sch Med, Galveston, TX 77555 USA. [Kotwal, Russ S.] USA Inst Surg Res, Joint Trauma Syst, Jbsa Ft Sam Houston, TX USA. [Mabry, Robert L.] USAISR, JTS, San Antonio, TX USA. [Robinson, John B.] DMRTI, San Antonio, TX USA. [Butler, Frank] US Mil Joint Trauma Syst, San Antonio, TX USA. RP Gerhardt, RT (reprint author), Brooke Army Med Ctr, Emergency Med, 3851 Roger Brooke Dr, San Antonio, TX 78234 USA. EM robert.gerhardt@us.army.mil RI Reeves, Patrick/F-8348-2016 OI Reeves, Patrick/0000-0002-1217-9795 NR 34 TC 2 Z9 2 U1 4 U2 5 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1090-3127 EI 1545-0066 J9 PREHOSP EMERG CARE JI Prehosp. Emerg. Care PD JAN 2 PY 2016 VL 20 IS 1 BP 37 EP 44 DI 10.3109/10903127.2015.1051683 PG 8 WC Emergency Medicine; Public, Environmental & Occupational Health SC Emergency Medicine; Public, Environmental & Occupational Health GA DA1DI UT WOS:000367536100006 PM 26727337 ER PT J AU Harmon, LM Cooper, RL Nugent, WR Butcher, JJ AF Harmon, Lisa M. Cooper, R. Lyle Nugent, William R. Butcher, Jimmie J. TI A review of the effectiveness of military suicide prevention programs in reducing rates of military suicides SO JOURNAL OF HUMAN BEHAVIOR IN THE SOCIAL ENVIRONMENT LA English DT Review DE Armed forces; military; prevention program; suicide ID RISK; CHOICE; ARMY AB The suicide rate within the U.S. armed forces remains a pressing issue for the country. This comprehensive literature review found only five published studies on military suicide prevention programs and their outcomes. Substantial research design and methodological issues are noted, and only one study produces statistically significant results. Findings reveal a serious lack of empirical evidence demonstrating effective suicide prevention programs within the U.S. armed forces. C1 [Harmon, Lisa M.; Cooper, R. Lyle; Nugent, William R.] Univ Tennessee, Coll Social Work, Knoxville, TN 37996 USA. [Butcher, Jimmie J.] Tripler Army Med Ctr, Dept Army, Honolulu, HI 96859 USA. RP Harmon, LM (reprint author), Univ Tennessee, Coll Social Work, Knoxville, TN 37996 USA. EM lharmon629@yahoo.com NR 23 TC 0 Z9 0 U1 0 U2 7 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 1091-1359 EI 1540-3556 J9 J HUM BEHAV SOC ENVI JI J. Hum. Behav. Soc. Environ. PD JAN 2 PY 2016 VL 26 IS 1 SI SI BP 15 EP 24 DI 10.1080/10911359.2015.1058139 PG 10 WC Social Work SC Social Work GA CW8XT UT WOS:000365283400003 ER PT J AU Walsh, ME AF Walsh, Marianne E. TI Analytical Methods for Detonation Residues of Insensitive Munitions SO JOURNAL OF ENERGETIC MATERIALS LA English DT Article DE DNAN; IMX-101; IMX-104; NTO; NQ ID PERFORMANCE LIQUID-CHROMATOGRAPHY; MASS-SPECTROMETRY; NITROGUANIDINE; NTO; 2,4-DINITROANISOLE; EXPLOSIVES; SEPARATION; PRODUCTS; IMX-104 AB Analytical methods are described for the analysis of post-detonation residues from insensitive munitions. Standard methods were verified or modified to obtain the mass of residues deposited per round. In addition, a rapid chromatographic separation was developed and used to measure the mass of NTO (3-nitro-1,2,4-triazol-5-one), NQ (nitroguanidine) and DNAN (2,4-dinitroanisole). The HILIC (hydrophilic-interaction chromatography) separation described here uses a trifunctionally-bonded amide phase to retain the polar analytes. The eluent is 75/25 v/v acetonitrile/water acidified with acetic acid, which is also suitable for LC/MS applications. Analytical runtime was three minutes. Solid phase extraction and LC/MS conditions are also described. C1 US Army, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Walsh, ME (reprint author), US Army, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM Marianne.E.Walsh@usace.army.mil FU SERDP [ER-2219] FX Support for this project was provided by the Strategic Environmental Research and Development Program, Andrea Leeson, Environmental Restoration Program Manager. Tests were conducted as a task within SERDP ER-2219, Michael R. Walsh and Sonia Thiboutot, Principal Investigators. The author thanks anonymous reviewers for constructive comments that improved the manuscript. NR 22 TC 1 Z9 1 U1 6 U2 20 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 0737-0652 EI 1545-8822 J9 J ENERG MATER JI J. Energ. Mater. PD JAN 2 PY 2016 VL 34 IS 1 BP 76 EP 91 DI 10.1080/07370652.2014.999173 PG 16 WC Chemistry, Applied; Chemistry, Physical; Engineering, Chemical; Materials Science, Multidisciplinary SC Chemistry; Engineering; Materials Science GA CW1VK UT WOS:000364779700007 ER PT S AU Ding, W Ganesh, MR Severinghaus, RN Corso, JJ Panagou, D AF Ding, Wei Ganesh, Madan Ravi Severinghaus, Robert N. Corso, Jason J. Panagou, Dimitra GP IEEE TI Real-Time Model Predictive Control for Keeping a Quadrotor Visible on the Camera Field-of-View of a Ground Robot SO 2016 AMERICAN CONTROL CONFERENCE (ACC) SE Proceedings of the American Control Conference LA English DT Proceedings Paper CT American Control Conference (ACC) CY JUL 06-08, 2016 CL Boston, MA SP Amer Automat Control Council ID AERIAL AB This paper considers a cooperative control design for an aerial/ground robot system, and addresses the problem of maintaining visibility of a quadrotor within the camera field-of-view of a ground robot in the presence of external disturbances. The quadrotor needs to be tracked by the ground robot with a monocular camera, and hence its motion should facilitate the ground vision-based tracking process by remaining in the effective camera sensing area. We design a model predictive controller (MPC) strategy where the visibility constraints of the camera and the control input constraints of the quadrotor are encoded into the cost function via barrier functions, and we adopt a fast MPC solver that is able to solve the optimization problem in real time. We also propose a method to enhance the robustness of the algorithm by suitably defining a restart method for the MPC solver. The applicability of the proposed algorithm is demonstrated through simulations and experimental results on real setups. C1 [Ding, Wei; Panagou, Dimitra] Univ Michigan, Dept Aerosp Engn, Ann Arbor, MI 48109 USA. [Ganesh, Madan Ravi; Corso, Jason J.] Univ Michigan, Dept Elect Engn & Comp Sci, Ann Arbor, MI 48109 USA. [Severinghaus, Robert N.] US Army TARDEC, Warren, MI USA. RP Ding, W (reprint author), Univ Michigan, Dept Aerosp Engn, Ann Arbor, MI 48109 USA. EM weiding@umich.edu; madantrg@umich.edu; robert.n.severinghaus.civ@mail.mil; jjcorso@umich.edu; dpanagou@umich.edu FU U.S. Army TARDEC [W56HZV-14-2-0001] FX This work was supported in part by U.S. Army TARDEC under agreement W56HZV-14-2-0001. NR 32 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 0743-1619 BN 978-1-4673-8682-1 J9 P AMER CONTR CONF PY 2016 BP 2259 EP 2264 PG 6 WC Automation & Control Systems SC Automation & Control Systems GA BG3XW UT WOS:000388376102052 ER PT S AU Paris, V Strizic, T Pusey, J Byl, K AF Paris, Virgile Strizic, Tom Pusey, Jason Byl, Katie GP IEEE TI Tools for the Design of Stable yet Nonsteady Bounding Control SO 2016 AMERICAN CONTROL CONFERENCE (ACC) SE Proceedings of the American Control Conference LA English DT Proceedings Paper CT American Control Conference (ACC) CY JUL 06-08, 2016 CL Boston, MA SP Amer Automat Control Council AB Control efforts on dynamic gaits for legged systems traditionally focus on limit cycles and their stability. However, there are many practical situations where step-tostep variability is highly desirable, for example to achieve variable footholds or to recover and replan after perturbations. In this paper we present an effective, high-level switching control framework for overcoming terrain obstacles using the familiar A* algorithm to search a mesh over the reachable space for a given set of controllers. In support of this, we present new low-level control strategies for generating stable bounding with planar models of a spring-legged quadruped robot, and demonstrate their use crossing gaps in the terrain. C1 [Paris, Virgile] ENSEIRB MATMECA, Bordeaux Inst Technol, 1 Ave Dr Albert Schweitzer,BP 99, F-33402 Talence, France. [Strizic, Tom; Byl, Katie] Univ Calif Santa Barbara, Dept Elect & Comp Engn, Santa Barbara, CA 93106 USA. [Pusey, Jason] US Army, Res Lab, Aberdeen Proving Ground, MD USA. RP Paris, V (reprint author), ENSEIRB MATMECA, Bordeaux Inst Technol, 1 Ave Dr Albert Schweitzer,BP 99, F-33402 Talence, France. EM paris.vgle@gmail.com; tstrizic@ece.ucsb.edu; jason.l.pusey.civ@mail.mil; katiebyl@ece.ucsb.edu FU U.S. Army's Robotics CTA [W911NF-08-R-0012]; NSF CAREER award [CMMI 1255018]; Summer Student Research Participation Program at the U.S. Army Research Laboratory FX This work was supported in part by the U.S. Army's Robotics CTA through grant No. W911NF-08-R-0012, by an NSF CAREER award (CMMI 1255018), and by the Summer Student Research Participation Program at the U.S. Army Research Laboratory administered by the Oak Ridge Institute for Science and Education. NR 21 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 0743-1619 BN 978-1-4673-8682-1 J9 P AMER CONTR CONF PY 2016 BP 4822 EP 4828 PG 7 WC Automation & Control Systems SC Automation & Control Systems GA BG3XW UT WOS:000388376104148 ER PT S AU Allik, B Piovoso, MJ Zurakowski, R AF Allik, Bethany Piovoso, Michael J. Zurakowski, Ryan GP IEEE TI Recursive Estimation with Quantized and Censored Measurements SO 2016 AMERICAN CONTROL CONFERENCE (ACC) SE Proceedings of the American Control Conference LA English DT Proceedings Paper CT American Control Conference (ACC) CY JUL 06-08, 2016 CL Boston, MA SP Amer Automat Control Council AB In this paper, we extend the Tobit Kalman filter for quantized measurements. Quantization occurs in many applications and systems and can usually be neglected in cases where the quantization interval is small. If this is not the case, the quantization effects cannot be ignored, and the nonlinearity induced by the quantizer must be addressed. Particle filters can be used, but are computationally expensive. Recently, the Tobit Kalman filter has been used to provide estimates when the measurement is a piecewise nonlinear censored regression model. The Tobit Kalman filter for quantized measurements derived in this paper is a computationally efficient algorithm, which converges to the optimal Kalman filter when quantization intervals become small. The derived estimator is compared to the Cramer Rao lower bound and the particle filter. C1 [Allik, Bethany] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Piovoso, Michael J.; Zurakowski, Ryan] Univ Delaware, Newark, DE 19716 USA. RP Allik, B (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM bethany.l.allik.civ@mail.mil; ryanz@udel.edu; piovoso@udel.edu FU Army Research Office [W911NF-10-1-0386] FX This work is supported by the Army Research Office under grant number W911NF-10-1-0386 NR 24 TC 0 Z9 0 U1 1 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 0743-1619 BN 978-1-4673-8682-1 J9 P AMER CONTR CONF PY 2016 BP 5130 EP 5135 PG 6 WC Automation & Control Systems SC Automation & Control Systems GA BG3XW UT WOS:000388376105033 ER PT S AU Cook, JT Ray, LE Lever, JH AF Cook, Joshua T. Ray, Laura E. Lever, James H. GP IEEE TI Dynamics Model for Mobility Optimization and Control of Off-Road Tractor Convoys SO 2016 AMERICAN CONTROL CONFERENCE (ACC) SE Proceedings of the American Control Conference LA English DT Proceedings Paper CT American Control Conference (ACC) CY JUL 06-08, 2016 CL Boston, MA SP Amer Automat Control Council AB This paper presents a generalized vehicle mode and leader-follower control architecture for an off-road, skid steered tracked vechicle. the modeling approach couples existing formulations in the literature for the powertrain components and the vechicle-terrain interaction to provide a comprehensive model that captures the salient features of terrain trafficability and predicts the vehicle's response over snow. this coupling is essential for making realistic predictions of the vechicle's mobility capabilities due to the power-load relationship at the engine output. simulation results show that over similar terrain,towing conditions, and input, neighboring trajectories of a leader-follower pair results, and controllers therefore need only to make small refinements to the control input. however, as the vechicles encounter different terrain and the risk of immobilization increase, an alternative control law is needed. under these circumstances, the model can be used for short term trajectoey prediction. C1 [Cook, Joshua T.; Ray, Laura E.] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. [Lever, James H.] US Army Cold Reg Res & Engn Lab, Hanover, NH USA. RP Cook, JT (reprint author), Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. EM joshua.t.cook.th@dartmouth.edu; lray@dartmouth.edu; james.lever@erdc.dren.mil FU NASA [NNX-10AL97H] FX This work was supported by NASA grant NNX-10AL97H NR 23 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 0743-1619 BN 978-1-4673-8682-1 J9 P AMER CONTR CONF PY 2016 BP 6875 EP 6880 PG 6 WC Automation & Control Systems SC Automation & Control Systems GA BG3XW UT WOS:000388376106154 ER PT S AU Cruz, PJ Sadler, BM Fierro, R AF Cruz, Patricio J. Sadler, Brian M. Fierro, Rafael GP IEEE TI Sensor Localization Using Hybrid RF/Optical Wireless Communications for an Aerial Data Mule SO 2016 AMERICAN CONTROL CONFERENCE (ACC) SE Proceedings of the American Control Conference LA English DT Proceedings Paper CT American Control Conference (ACC) CY JUL 06-08, 2016 CL Boston, MA SP Amer Automat Control Council AB In this paper we consider the problem of pairing a ground sensor with an aerial vehicle, both equipped with a hybrid communication system - radio frequency for non-line of sight transmission and optical for line-of-sight transmission. These communication technologies are complementary and by coordinating them it is possible to mitigate their respective weaknesses. A challenging problem is positioning the flying robot within optical communication range, especially when the distance is large and the sensor location is unknown. In this work, we propose a solution to the problem of autonomously localizing the sensor node relative to the aerial vehicle. We take advantage of the hybrid communication scheme by developing a control strategy that uses the radio signal to guide the aerial platform to the sensor node. Once the optical-based signal strength is over a desired threshold the robot hovers within optical range. The control strategy is demonstrated through simulations that incorporate a realistic model for the hybrid communication link. C1 [Cruz, Patricio J.; Fierro, Rafael] Univ New Mexico, Dept Elect & Comp Engn, Albuquerque, NM 87131 USA. [Sadler, Brian M.] Army Res Lab, Adelphi, MD 20783 USA. RP Cruz, PJ (reprint author), Univ New Mexico, Dept Elect & Comp Engn, Albuquerque, NM 87131 USA. EM pcruzec@unm.edu; brian.m.sadler6.civ@mail.mil; rfierro@unm.edu FU ARL MAST CTA [W911NF-08-2-0004]; SENESCYT Ecuadorian Scholarship Program FX This work was supported in part by ARL MAST CTA #W911NF-08-2-0004. We would like to thank the SENESCYT Ecuadorian Scholarship Program for providing part of the financial support of P. J. Cruz. NR 25 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 0743-1619 BN 978-1-4673-8682-1 J9 P AMER CONTR CONF PY 2016 BP 7085 EP 7091 PG 7 WC Automation & Control Systems SC Automation & Control Systems GA BG3XW UT WOS:000388376107025 ER PT S AU Lee, H Kwon, H AF Lee, Hyungtae Kwon, Heesung GP IEEE TI CONTEXTUAL DEEP CNN BASED HYPERSPECTRAL CLASSIFICATION SO 2016 IEEE INTERNATIONAL GEOSCIENCE AND REMOTE SENSING SYMPOSIUM (IGARSS) SE IEEE International Symposium on Geoscience and Remote Sensing IGARSS LA English DT Proceedings Paper CT 36th IEEE International Geoscience and Remote Sensing Symposium (IGARSS) CY JUL 10-15, 2016 CL Beijing, PEOPLES R CHINA SP Inst Elect & Elect Engineers, Inst Elect & Elect Engineers, Geoscience & Remote Sensing Soc, NSSC DE contextual deep CNN; joint spectral and spatial exploitation; hyperspectral classification AB In this paper, we describe a novel deep convolutional neural networks (CNN) based approach called contextual deep CNN that can jointly exploit spatial and spectral features for hyperspectral image classification. The contextual deep CNN first concurrently applies multiple 3-dimensional local convolutional filters with different sizes jointly exploiting spatial and spectral features of a hyperspectral image. The initial spatial and spectral feature maps obtained from applying the variable size convolutional filters are then combined together to form a joint spatio-spectral feature map. The joint feature map representing rich spectral and spatial properties of the hyperspectral image is then fed through fully convolutional layers that eventually predict the corresponding label of each pixel vector. The proposed approach is tested on two benchmark datasets: the Indian Pines dataset and the Pavia University scene dataset. Performance comparison shows enhanced classification performance of the proposed approach over the current state of the art on both datasets. C1 [Lee, Hyungtae; Kwon, Heesung] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RP Lee, H (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 7 TC 0 Z9 0 U1 1 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2153-6996 BN 978-1-5090-3332-4 J9 INT GEOSCI REMOTE SE PY 2016 BP 3322 EP 3325 PG 4 WC Engineering, Electrical & Electronic; Geosciences, Multidisciplinary; Remote Sensing SC Engineering; Geology; Remote Sensing GA BG3QG UT WOS:000388114603087 ER PT S AU Gilani, SN Sheetz, K Lucas, G Traum, D AF Gilani, Setareh Nasihati Sheetz, Kraig Lucas, Gale Traum, David BE Traum, D Swartout, W Khooshabeh, P Kopp, S Scherer, S Leuski, A TI What Kind of Stories Should a Virtual Human Swap? SO INTELLIGENT VIRTUAL AGENTS, IVA 2016 SE Lecture Notes in Artificial Intelligence LA English DT Proceedings Paper CT 16th International Conference on Intelligent Virtual Agents (IVA) CY SEP 20-23, 2016 CL Los Angeles, CA SP Alelo, Springer, Univ So Calif, Inst Creat Technologies AB Telling stories is an important aspect virtual agents designed to interact with people socially over time. We describe an experiment designed to investigate the impact of the identity, presentation form, and perspective of a virtual storyteller on a human user who engages in a story-swapping activity with two virtual characters. For each interaction, the user was given 10 "ice-breaker" questions to ask a virtual character and respond to the character's reciprocal request. Participants also filled out a post-interaction survey, measuring rapport with the character and impressions of the character's personality. Results generally show that participants prefer characters who tell first person stories, however there were some interactions with presentation order. No significant preferences were established for the form or identity variables. C1 [Gilani, Setareh Nasihati; Lucas, Gale; Traum, David] USC Inst Creat Technol, 12015 Waterfront Dr, Playa Vista, CA 90094 USA. [Sheetz, Kraig] US Mil Acad, West Point, NY 10996 USA. RP Gilani, SN (reprint author), USC Inst Creat Technol, 12015 Waterfront Dr, Playa Vista, CA 90094 USA. EM sngilani@ict.usc.edu; Kraig.Sheetz2@usma.edu; lucas@ict.usc.edu; traum@ict.usc.edu NR 22 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0302-9743 BN 978-3-319-47665-0; 978-3-319-47664-3 J9 LECT NOTES ARTIF INT PY 2016 VL 10011 BP 128 EP 140 DI 10.1007/978-3-319-47665-0_12 PG 13 WC Computer Science, Artificial Intelligence SC Computer Science GA BG6GQ UT WOS:000390287300012 ER PT S AU Hobbs, RL AF Hobbs, Reginald L. BE Traum, D Swartout, W Khooshabeh, P Kopp, S Scherer, S Leuski, A TI A Distributed Intelligent Agent Approach to Context in Information Retrieval SO INTELLIGENT VIRTUAL AGENTS, IVA 2016 SE Lecture Notes in Artificial Intelligence LA English DT Proceedings Paper CT 16th International Conference on Intelligent Virtual Agents (IVA) CY SEP 20-23, 2016 CL Los Angeles, CA SP Alelo, Springer, Univ So Calif, Inst Creat Technologies DE Intelligent agents; Natural language processing; Fuzzy logic; Quality of information AB Information retrieval across disadvantaged networks requires intelligent agents that can make decisions about what to transmit in such a way as to minimize network performance impact while maximizing utility and quality of information (QOI). Specialized agents at the source need to process unstructured, ad-hoc queries, identifying both the context and the intent to determine the implied task. Knowing the task will allow the distributed agents that service the requests to filter, summarize, or transcode data prior to responding, lessening the network impact. This paper describes an approach that uses natural language processing (NLP) techniques, multi-valued logic based inferencing, distributed intelligent agents, and task-relevant metrics for information retrieval. C1 [Hobbs, Reginald L.] US Army, Res Lab, Adelphi, MD 20783 USA. RP Hobbs, RL (reprint author), US Army, Res Lab, Adelphi, MD 20783 USA. EM reginald.l.hobbs2.civ@mail.mil NR 6 TC 0 Z9 0 U1 1 U2 1 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0302-9743 BN 978-3-319-47665-0; 978-3-319-47664-3 J9 LECT NOTES ARTIF INT PY 2016 VL 10011 BP 475 EP 478 DI 10.1007/978-3-319-47665-0_58 PG 4 WC Computer Science, Artificial Intelligence SC Computer Science GA BG6GQ UT WOS:000390287300058 ER PT S AU Marge, M Bonial, C Pollard, KA Artstein, R Byrne, B Hill, SG Voss, C Traum, D AF Marge, Matthew Bonial, Claire Pollard, Kimberly A. Artstein, Ron Byrne, Brendan Hill, Susan G. Voss, Clare Traum, David BE Traum, D Swartout, W Khooshabeh, P Kopp, S Scherer, S Leuski, A TI Assessing Agreement in Human-Robot Dialogue Strategies: A Tale of Two Wizards SO INTELLIGENT VIRTUAL AGENTS, IVA 2016 SE Lecture Notes in Artificial Intelligence LA English DT Proceedings Paper CT 16th International Conference on Intelligent Virtual Agents (IVA) CY SEP 20-23, 2016 CL Los Angeles, CA SP Alelo, Springer, Univ So Calif, Inst Creat Technologies DE Natural language dialogue; Human-robot communication AB The Wizard-of-Oz (WOz) method is a common experimental technique in virtual agent and human-robot dialogue research for eliciting natural communicative behavior from human partners when full autonomy is not yet possible. For the first phase of our research reported here, wizards play the role of dialogue manager, acting as a robot's dialogue processing. We describe a novel step within WOz methodology that incorporates two wizards and control sessions: the wizards function much like corpus annotators, being asked to make independent judgments on how the robot should respond when receiving the same verbal commands in separate trials. We show that inter-wizard discussion after the control sessions and the resolution with a reconciled protocol for the follow-on pilot sessions successfully impacts wizard behaviors and significantly aligns their strategies. We conclude that, without control sessions, we would have been unlikely to achieve both the natural diversity of expression that comes with multiple wizards and a better protocol for modeling an automated system. C1 [Marge, Matthew; Pollard, Kimberly A.; Byrne, Brendan; Hill, Susan G.; Voss, Clare] US Army, Res Lab, Adelphi, MD 20783 USA. [Artstein, Ron; Traum, David] USC Inst Creat Technol, Playa Vista, CA 90094 USA. RP Marge, M (reprint author), US Army, Res Lab, Adelphi, MD 20783 USA. EM matthew.r.marge.civ@mail.mil NR 4 TC 0 Z9 0 U1 1 U2 1 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0302-9743 BN 978-3-319-47665-0; 978-3-319-47664-3 J9 LECT NOTES ARTIF INT PY 2016 VL 10011 BP 484 EP 488 DI 10.1007/978-3-319-47665-0_60 PG 5 WC Computer Science, Artificial Intelligence SC Computer Science GA BG6GQ UT WOS:000390287300060 ER PT S AU McDaniel, S Boothe, DL Crone, JC Park, SJ Shires, DR Yu, AB Taufer, M AF McDaniel, Sean Boothe, David L. Crone, Joshua C. Park, Song J. Shires, Dale R. Yu, Alfred B. Taufer, Michela BE Liao, X Lovas, R Shen, X Zheng, R TI Study of Neocortex Simulations with GENESIS on High Performance Computing Resources SO 2016 IEEE 22ND INTERNATIONAL CONFERENCE ON PARALLEL AND DISTRIBUTED SYSTEMS (ICPADS) SE International Conference on Parallel and Distributed Systems - Proceedings LA English DT Proceedings Paper CT 22nd IEEE International Conference on Parallel and Distributed Systems (ICPADS) CY DEC 13-16, 2016 CL Wuhan, PEOPLES R CHINA SP IEEE, IEEE Comp Soc, Huazhong Univ Sci & Technol ID NEURONS AB One significant challenge in neuroscience is understanding the cooperative behavior of large numbers of neurons. Models of neuronal networks allow scientists to explore the impact of differential neuronal connectivity using analysis techniques and information not available experimentally. However, modeling realistic neurobiological processes and encoding them in computer simulations is challenging, as increasing computing and data requirements are all of concern. In this work we study the performance of neocortex simulations using GEneral NEural SImulation System (GENESIS), a well-known multi-function brain simulation package, supported by high performance computing resources. The contribution of our work is threefold. First, we study the impact of platforms (i.e., single fat nodes versus high-end clusters) and their features on the performance and data generation for a small scale model of neocortex. Second, we assess the impact of the model complexity (i.e., number of cells and cell connectivity) on the performance and data generation for increasingly large versions of the neocortex model on high-end clusters. Third, we provide selected scientific results obtained by increasing the model complexity. We show that the more realistic and rigorous modeling of neocortex functions is computationally feasible but requires high performance computing resources to mitigate the growing computing and data requests of the associated simulations. C1 [McDaniel, Sean; Taufer, Michela] Univ Delaware, Newark, DE 19716 USA. [Boothe, David L.] Army Res Lab, Altus Engn, Aberdeen Proving Ground, MD USA. [Crone, Joshua C.; Park, Song J.; Shires, Dale R.; Yu, Alfred B.] US Army Res Lab, Aberdeen Proving Ground, MD USA. RP McDaniel, S (reprint author), Univ Delaware, Newark, DE 19716 USA. EM seanmcd@udel.edu; david.l.boothe7.ctr@mail.mil; joshua.crone.civ@mail.mil; song.j.park@mail.mil; dale.r.shires@mail.mil; alfred.b.yu.civ@mail.mil; taufer@udel.edu FU U.S. Army Research Laboratory [N911NF-15-2003] FX This work was supportd by the U.S. Army Research Laboratory under Cooperative Agreement Number N911NF-15-2003. NR 17 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1521-9097 BN 978-1-5090-4457-3 J9 INT C PAR DISTRIB SY PY 2016 BP 924 EP 931 DI 10.1109/ICPADS.2016.122 PG 8 WC Computer Science, Hardware & Architecture SC Computer Science GA BG9GX UT WOS:000393188800114 ER PT S AU Singh, PK Nguyen, JH Gupta, SK Kar, K Ku, D AF Singh, Prateek K. Nguyen, James H. Gupta, Santosh K. Kar, Koushik Ku, Daniel GP IEEE TI High Performance Mass Configuration Protocols for MANETs using Efficient Broadcasting SO 2016 IEEE 35TH INTERNATIONAL PERFORMANCE COMPUTING AND COMMUNICATIONS CONFERENCE (IPCCC) SE IEEE International Performance Computing and Communications Conference (IPCCC) LA English DT Proceedings Paper CT 35th IEEE International Performance Computing and Communications Conference (IPCCC) CY DEC 09-11, 2016 CL Las Vegas, NV SP IEEE ID AD-HOC NETWORKS AB In this work we present the design and evaluation of two high performance mass configuration protocols, focusing on efficiency and reliability, for wireless Mobile Ad-hoc Networks (MANETs) utilizing an Efficient Broadcast Module (EBM). MCONF, which was developed in an earlier work, enables mass configuration changes in a MANET using multiple modes of operation based on the underlying network scenario. However, MCONF relies on classic flooding approach to disseminate configuration changes and gather feedback information to/from nodes. In this paper we propose: S-MCONF - a Simple Mass Configuration protocol focusing on efficiency, and E-MCONF - an Efficient Mass Configuration protocol focusing on reliability. Both of these are developed based on MCONF while utilizing underlying efficient broadcasting framework that computes a Minimum Connected Dominating Set (MCDS) to forward messages in a MANET. Our proposed S-MCONF and E-MCONF protocols utilize three different relay selection algorithms, namely Essential Connecting Dominating Set (E-CDS), Source based MultiPoint Relay (S-MPR) and Non-source specific MultiPoint Relay (NS-MPR), to optimize performance. We evaluate the performance of our S-MCONF and E-MCONF protocols by emulating MANET on Common Open Research Emulator (CORE) for dynamic topologies based on mobility of nodes. Performance is measured in terms of reliability and packet redundancy. Based on our findings as part of the study, it is observed that S-MCONF is very well suited for low node mobility scenarios in the MANETs. On the other hand, E-MCONF provides reliability of packet delivery in MANETs even for high node mobility scenarios. Both S-MCONF and E-MCONF are able to improve their packet efficiency significantly at low mobility as compared to MCONF protocol. C1 [Singh, Prateek K.; Gupta, Santosh K.; Kar, Koushik] Rensselaer Polytech Inst, Troy, NY 12180 USA. [Nguyen, James H.; Ku, Daniel] US Army, CERDEC, Aberdeen Proving Ground, MD 21005 USA. RP Singh, PK (reprint author), Rensselaer Polytech Inst, Troy, NY 12180 USA. FU RDECOM Contracting Center; RTP Division; Army Research Laboratory [W911NF-09-D-0006]; Raytheon BBN Technologies Corp. FX The research reported in this work was supported by the RDECOM Contracting Center, RTP Division and the Army Research Laboratory under Contract Number W911NF-09-D-0006 under a subcontract from Raytheon BBN Technologies Corp. The views and conclusions contained in this work are those of the authors and should not be interpreted as presenting the official policies or position, either expressed or implied, of the RDECOM Contracting Center, RTP Division and the Army Research Laboratory or the U.S. Government unless so designated by other official documents. Citation of manufacturers or trade names does not constitute an official endorsement or approval of the use thereof. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation hereon. NR 25 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1097-2641 BN 978-1-5090-5252-3 J9 IEEE IPCCC PY 2016 PG 10 WC Computer Science, Hardware & Architecture; Engineering, Electrical & Electronic; Telecommunications SC Computer Science; Engineering; Telecommunications GA BG9QB UT WOS:000393582600024 ER PT J AU Brantly, AF AF Brantly, Aaron F. TI Aesop's wolves: the deceptive appearance of espionage and attacks in cyberspace SO INTELLIGENCE AND NATIONAL SECURITY LA English DT Article AB Appearances in cyberspace are deceptive and problematic. Deception in the cyber domain poses an immensely difficult challenge for states to differentiate between espionage activities in cyberspace and cyber attacks. The inability to distinguish between cyber activities places US cyber infrastructure in a perilous position and increases the possibility of a disproportionate or inadequate response to cyber incidents. This paper uses case analysis to examine the characteristics associated with the tools and decisions related to cyber espionage and cyber attacks to develop a framework for distinction leveraging epidemiological models for combating disease. C1 [Brantly, Aaron F.] US Mil Acad, Dept Social Sci, Int Relat & Cybersecur, West Point, NY 10996 USA. [Brantly, Aaron F.] US Mil Acad, Army Cyber Inst, West Point, NY 10996 USA. [Brantly, Aaron F.] US Mil Acad, Combating Terrorism Ctr, West Point, NY 10996 USA. RP Brantly, AF (reprint author), US Mil Acad, Dept Social Sci, Int Relat & Cybersecur, West Point, NY 10996 USA.; Brantly, AF (reprint author), US Mil Acad, Army Cyber Inst, West Point, NY 10996 USA.; Brantly, AF (reprint author), US Mil Acad, Combating Terrorism Ctr, West Point, NY 10996 USA. EM aaron.brantly@usma.edu NR 21 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0268-4527 EI 1743-9019 J9 INTELL NATL SECUR JI Intell. Natl. Secur. PY 2016 VL 31 IS 5 BP 674 EP 685 DI 10.1080/02684527.2015.1077620 PG 12 WC International Relations SC International Relations GA EL1CF UT WOS:000394357400002 ER PT J AU Chang, W Tetlock, PE AF Chang, Welton Tetlock, Philip E. TI Rethinking the training of intelligence analysts SO INTELLIGENCE AND NATIONAL SECURITY LA English DT Article ID ERROR MANAGEMENT THEORY; DECISION-MAKING; ACCURACY; UNDERCONFIDENCE; PSYCHOLOGY; EVOLUTION; BIASES; OVERCONFIDENCE; OVERREACTION; PROBABILITY AB Despite intense scrutiny and promised fixes resulting from intelligence 'transformation' efforts, erroneous analytic assessments persist and continue to dominate news coverage of the US intelligence community. Existing analytic training teaches analysts about common cognitive biases and then aims to correct them with structured analytic techniques. On its face, this approach is eminently reasonable; on close inspection, incomplete and imbalanced. Current training is anchored in a mid-twentieth century understanding of psychology that focuses on checking over-confidence and rigidity but ignores the problems of under-confidence and excessive volatility. Moreover it has never been validated against objective benchmarks of good judgment. We propose a new approach: (a) adopting scientifically validated content and regularly testing training to avoid institutionalizing new dogmas; (b) incentivizing analysts to view training guidelines as means to the end of improved accuracy, not an end in itself. C1 [Chang, Welton] Univ Penn, Philadelphia, PA 19104 USA. [Chang, Welton] US Army, Ft Belvoir, VA 22060 USA. [Chang, Welton] Def Intelligence Agcy, Washington, DC 20340 USA. [Tetlock, Philip E.] Univ Penn, Psychol, Philadelphia, PA 19104 USA. [Tetlock, Philip E.] Univ Penn, Wharton Sch, Philadelphia, PA 19104 USA. [Tetlock, Philip E.] Univ Penn, Polit Sci, Philadelphia, PA 19104 USA. RP Chang, W (reprint author), Univ Penn, Philadelphia, PA 19104 USA.; Chang, W (reprint author), US Army, Ft Belvoir, VA 22060 USA.; Chang, W (reprint author), Def Intelligence Agcy, Washington, DC 20340 USA. EM welton@sas.upenn.edu FU Wharton Global Initiatives program FX We thank the Wharton Global Initiatives program for its generous support of our research and Kelsie Piedra for assistance with manuscript preparation. We also thank Jeffrey Friedman, David Mandel, Mark Parker, Carrie Plummer, and three anonymous reviewers for their insightful comments and critiques. NR 116 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0268-4527 EI 1743-9019 J9 INTELL NATL SECUR JI Intell. Natl. Secur. PY 2016 VL 31 IS 6 SI SI BP 903 EP 920 DI 10.1080/02684527.2016.1147164 PG 18 WC International Relations SC International Relations GA EL1CI UT WOS:000394357700009 ER PT J AU Grew, KN McClure, JP Chu, D Kohl, PA Ahlfield, JM AF Grew, Kyle N. McClure, Joshua P. Chu, Deryn Kohl, Paul A. Ahlfield, John M. TI Understanding Transport at the Acid-Alkaline Interface of Bipolar Membranes SO JOURNAL OF THE ELECTROCHEMICAL SOCIETY LA English DT Article ID ANION-EXCHANGE MEMBRANES; FIXED CHARGE MEMBRANES; P-N-JUNCTIONS; ION-TRANSPORT; FUEL-CELLS; WATER DISSOCIATION; REACTION-KINETICS; CARBON-DIOXIDE; HYBRID ANION; ELECTROLYTE AB The combination of cation exchange membrane (CEM) and anion exchange membrane (AEM) electrolytes to form of a hybrid, or bipolar membrane (BPM) electrolyte, can have unique advantages for electrochemical systems including fuel cells, electrolyzers, electrodialysis, and photovoltaic solar-to-fuel devices. However, a major challenge for this approach is the development of a stable and active interfacial region (i.e., junction) that adjoins the CEM and AEM layers. Moreover, a fundamental understanding of transport at the CEM-AEM junction is lacking. Therefore, the present study focuses on the theoretical development and analysis of the nature of the BPM interface. A Poisson-Nernst-Planck (PNP) theory is formalized and applied to a representative BPM interface. The findings are reported in terms of bias (i.e., overpotential) in a galvanic device with respect to CEM and AEM material requirements. Specific attention is paid to our interests in the application of the BPM to a fuel cell device with an acidic (CEM) anode and alkaline (AEM) cathode. We demonstrate that a BPM with an acidic CEM anode and alkaline AEM cathode must promote a trap-assisted type of recombination mechanism under forward bias. Without such a mechanism, large overpotentials are needed to drive ionic recombination processes. (C) The Author(s) 2016. Published by ECS. All rights reserved. C1 [Grew, Kyle N.; McClure, Joshua P.; Chu, Deryn] US Army, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. [Kohl, Paul A.; Ahlfield, John M.] Georgia Inst Technol, Sch Chem & Bimol Engn, Atlanta, GA 30332 USA. RP Grew, KN (reprint author), US Army, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. EM kyle.n.grew.civ@mail.mil FU U.S. Department of the Army; U.S. Army Material Command (AMC); U.S. Office of the Deputy Assistant Secretary of the Army for Defense Exports and Cooperation (DASA-DEC); U.S. Army Research Laboratory [W911NF-14-2-0008] FX KNG, JPM, and DC gratefully acknowledge the U.S. Department of the Army and U.S. Army Material Command (AMC) for supporting this work. PAK and JMA gratefully acknowledge financial support from the from the U.S. Office of the Deputy Assistant Secretary of the Army for Defense Exports and Cooperation (DASA-DE&C) and the U.S. Army Research Laboratory, W911NF-14-2-0008. The authors would also like to thank Dr. David Baker & Dr. Oleg Borodin of the U.S. Army Research Laboratory and Ms. Lisha Liu of Georgia Tech for helpful discussions. NR 55 TC 0 Z9 0 U1 4 U2 4 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 65 SOUTH MAIN STREET, PENNINGTON, NJ 08534 USA SN 0013-4651 EI 1945-7111 J9 J ELECTROCHEM SOC JI J. Electrochem. Soc. PY 2016 VL 163 IS 14 BP F1572 EP F1587 DI 10.1149/2.0941614jes PG 16 WC Electrochemistry; Materials Science, Coatings & Films SC Electrochemistry; Materials Science GA EK3TV UT WOS:000393852200113 ER PT J AU Mackie, DM Jahnke, JP Benyamin, MS Sumner, JJ AF Mackie, David M. Jahnke, Justin P. Benyamin, Marcus S. Sumner, James J. TI Simple, fast, and accurate methodology for quantitative analysis using Fourier transform infrared spectroscopy, with bio-hybrid fuel cell examples SO METHODSX LA English DT Article DE Fourier transform infrared; FTIR; Quantitative analysis; Methodology; Fuel cell ID IR; DISCRIMINATION; IDENTIFICATION; FTIR AB The standard methodologies for quantitative analysis (QA) of mixtures using Fourier transform infrared (FTIR) instruments have evolved until they are now more complicated than necessary for many users' purposes. We present a simpler methodology, suitable for widespread adoption of FTIR QA as a standard laboratory technique across disciplines by occasional users. Algorithm is straightforward and intuitive, yet it is also fast, accurate, and robust. Relies on component spectra, minimization of errors, and local adaptive mesh refinement. Tested successfully on real mixtures of up to nine components. We show that our methodology is robust to challenging experimental conditions such as similar substances, component percentages differing by three orders of magnitude, and imperfect (noisy) spectra. As examples, we analyze biological, chemical, and physical aspects of bio-hybrid fuel cells. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). C1 [Mackie, David M.; Jahnke, Justin P.; Benyamin, Marcus S.; Sumner, James J.] US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RP Mackie, DM (reprint author), US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM david.m.mackie.civ@mail.mil NR 13 TC 1 Z9 1 U1 1 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 2215-0161 J9 METHODSX JI MethodsX PY 2016 VL 3 BP 128 EP 138 DI 10.1016/j.mex.2016.02.002 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EJ7KQ UT WOS:000393401000015 PM 26977411 ER PT S AU Akogwu, I Wang, N Zhang, CY Hong, HX Choi, H Gong, P AF Akogwu, Isaac Wang, Nan Zhang, Chaoyang Hong, Huixiao Choi, Hwanseok Gong, Ping BE Tian, T Jiang, Q Liu, Y Burrage, K Song, J Wang, Y Hu, X Morishita, S Zhu, Q Wang, G TI Factorial Analysis of Error Correction Performance Using Simulated Next-Generation Sequencing Data SO 2016 IEEE INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICINE (BIBM) SE IEEE International Conference on Bioinformatics and Biomedicine-BIBM LA English DT Proceedings Paper CT IEEE International Conference on Bioinformatics and Biomedicine (IEEE BIBM) CY DEC 15-18, 2016 CL Shenzhen, PEOPLES R CHINA SP IEEE, IEEE Comp Soc, Natl Sci Fdn, Harbin Inst Technol DE next-generation sequencing; performance metrics; error correction; multi-way ANOVA; k-mer spectrum; genome size; read length; coverage depth; simulation study; precision; F-score ID SINGLE-NUCLEOTIDE VARIANTS; READS; BIAS AB Error correction is a critical initial step in next-generation sequencing (NGS) data analysis. Although more than 60 tools have been developed, there is no systematic evidence-based comparison with regard to their strength and weakness, especially in terms of correction accuracy. Here we report a full factorial simulation study to examine how NGS dataset characteristics (genome size, coverage depth and read length in particular) affect error correction performance (precision and F-score), as well as to compare performance sensitivity/resistance of six k-mer spectrum-based methods to variations in dataset characteristics. Multi-way ANOVA tests indicate that choice of correction method and dataset characteristics had significant effects on performance metrics. Overall, BFC, Bless, Bloocoo and Musket performed better than Lighter and Trowel on 27 synthetic datasets. For each chosen method, read length and coverage depth showed more pronounced impact on performance than genome size. This study shed insights to the performance behavior of error correction methods in response to the common variables one would encounter in real-world NGS datasets. It also warrants further studies of wet lab-generated experimental NGS data to validate findings obtained from this simulation study. C1 [Akogwu, Isaac; Wang, Nan; Zhang, Chaoyang] Univ Southern Mississippi, Sch Comp, Hattiesburg, MS 39406 USA. [Hong, Huixiao] US FDA, Div Bioinformat & Biostat, Natl Ctr Toxicol Res, Jefferson, AR USA. [Choi, Hwanseok] Univ Southern Mississippi, Dept Publ Hlth, Hattiesburg, MS 39406 USA. [Gong, Ping] US Army Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS USA. RP Zhang, CY (reprint author), Univ Southern Mississippi, Sch Comp, Hattiesburg, MS 39406 USA. EM Chaoyang.zhang@usm.edu; Ping.Gong@usace.army.mil FU U.S. Army Environmental Quality/Installation (EQI) Basic Research Program; National Science Foundation [EPS 0903787] FX This work was supported by an intramural grant from the U.S. Army Environmental Quality/Installation (EQI) Basic Research Program to PG and a sub-award of National Science Foundation award EPS 0903787 to CZ and NW. Permission was granted by the Chief of Engineer to publish this paper. NR 24 TC 0 Z9 0 U1 0 U2 0 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1264 USA SN 2156-1125 BN 978-1-5090-1610-5 J9 IEEE INT C BIOINFORM PY 2016 BP 1164 EP 1169 PG 6 WC Computer Science, Interdisciplinary Applications; Medical Informatics SC Computer Science; Medical Informatics GA BG9GY UT WOS:000393191700200 ER PT J AU Koppel, A Fink, J Warnell, G Stump, E Ribeiro, A AF Koppel, Alec Fink, Jonathan Warnell, Garrett Stump, Ethan Ribeiro, Alejandro GP IEEE TI Online Learning for Characterizing Unknown Environments in Ground Robotic Vehicle Models SO 2016 IEEE/RSJ INTERNATIONAL CONFERENCE ON INTELLIGENT ROBOTS AND SYSTEMS (IROS 2016) LA English DT Proceedings Paper CT IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS) CY OCT 09-14, 2016 CL Daejeon, SOUTH KOREA SP IEEE, RSJ ID MINIMIZATION; PREDICTION AB In pursuit of increasing the operational tempo of a ground robotics platform in unknown domains, we consider the problem of predicting the distribution of structural state-estimation error due to poorly-modeled platform dynamics as well as environmental effects. Such predictions are a critical component of any modern control approach that utilizes uncertainty information to provide robustness in control design. We use an online learning algorithm based on matrix factorization techniques to fit a statistical model of error that provides enough expressive power to enable prediction directly from motion control signals and low-level visual features. Moreover, we empirically demonstrate that this technique compares favorably to predictors that do not incorporate this information. C1 [Koppel, Alec; Ribeiro, Alejandro] Univ Penn, Dept ESE, 200 South 33rd St, Philadelphia, PA 19104 USA. [Fink, Jonathan; Warnell, Garrett; Stump, Ethan] US Army, Res Lab, Computat & Informat Sci Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RP Koppel, A (reprint author), Univ Penn, Dept ESE, 200 South 33rd St, Philadelphia, PA 19104 USA. EM akoppel@seas.upenn.edu; jonathan.r.fink3.civ@mail.mil; garrett.a.warnell.civ@mail.mil; ethan.a.stump2.civ@mail.mil; aribeiro@seas.upenn.edu FU ASEE SMART; ARL MAST CTA FX Work in this paper is supported by ASEE SMART and ARL MAST CTA. NR 24 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-5090-3762-9 PY 2016 BP 626 EP 633 PG 8 WC Computer Science, Artificial Intelligence; Robotics SC Computer Science; Robotics GA BG7XO UT WOS:000391921700092 ER PT J AU Twigg, JN Gregory, JM Fink, JR AF Twigg, Jeffrey N. Gregory, Jason M. Fink, Jonathan R. GP IEEE TI Towards Online Characterization of Autonomously Navigating Robots in Unstructured Environments SO 2016 IEEE/RSJ INTERNATIONAL CONFERENCE ON INTELLIGENT ROBOTS AND SYSTEMS (IROS 2016) LA English DT Proceedings Paper CT IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS) CY OCT 09-14, 2016 CL Daejeon, SOUTH KOREA SP IEEE, RSJ AB Autonomous platforms are confronted by a diversity of challenges in unstructured environments, which make monitoring performance a non-trivial task. Some of these environments are so complex that they preclude persistent, nearby operator oversight. This absence of oversight motivates the need for an online monitoring system, specifically for robots operating in difficult environments. We develop a test methodology and set of online monitoring metrics by extending methods for characterizing robotic-systems using offline metrics. We implement this test methodology in an unstructured, outdoor environment and show the resulting performance information gained from our online monitoring solution. This online monitoring approach is generalizable such that it characterizes any robotic system that meets our set of hardware and software criteria. C1 [Twigg, Jeffrey N.; Gregory, Jason M.; Fink, Jonathan R.] US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RP Twigg, JN (reprint author), US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM jeffrey.n.twigg.civ@mail.mil; jason.m.gregory1.civ@mail.mil; jonathan.r.fink3.civ@mail.mil NR 24 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-5090-3762-9 PY 2016 BP 1198 EP 1205 PG 8 WC Computer Science, Artificial Intelligence; Robotics SC Computer Science; Robotics GA BG7XO UT WOS:000391921701055 ER PT J AU Li, C Kessens, CC Young, A Fearing, RS Full, RJ AF Li, Chen Kessens, Chad C. Young, Austin Fearing, Ronald S. Full, Robert J. GP IEEE TI Cockroach-inspired winged robot reveals principles of ground-based dynamic self-righting SO 2016 IEEE/RSJ INTERNATIONAL CONFERENCE ON INTELLIGENT ROBOTS AND SYSTEMS (IROS 2016) LA English DT Proceedings Paper CT IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS) CY OCT 09-14, 2016 CL Daejeon, SOUTH KOREA SP IEEE, RSJ ID DESIGN; MANIPULATION; CAPABILITIES; LOCOMOTION; INSECTA AB Animals and robots alike face challenges of flipping-over as they move in complex terrain. Small insects like cockroaches can rapidly right themselves when upside down, yet small fast-running legged robots are much less capable of ground-based self-righting. Inspired by the discoid cockroach that opens its wings to push against the ground to self-right, we designed actuated wings for robot self-righting based on recently-developed rounded shells for obstacle traversal In We measured the self-righting performance of a robot using these actuated wings, and systematically studied the effects and trade-offs of wing opening magnitude, speed, symmetry, and wing geometry. Our study provided a proof-of-concept that robots can take advantage of an existing body structure (rounded shell) in novel ways (as actuated wings) to serve new locomotor functions, analogous to biological exaptations [2]. Our results demonstrated that the robot self-rights dynamically, with active wing pushing followed by passive falling, and benefits from increasing kinetic energy by pushing faster and longer. Our experiments also showed that opening both wings asymmetrically increases righting probability at low wing opening magnitudes. C1 [Li, Chen] Johns Hopkins Univ, Baltimore, MD 21218 USA. [Kessens, Chad C.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Young, Austin; Fearing, Ronald S.; Full, Robert J.] Univ Calif Berkeley, Berkeley, CA 94720 USA. RP Li, C (reprint author), Johns Hopkins Univ, Baltimore, MD 21218 USA. EM chen.li@jhu.edu FU Burroughs Wellcome Fund Career Award at the Scientific Interface (C.L.); Miller Institute for Basic Research in Science; University of California, Berkeley (C.L.); United States Army Research Laboratory under the Micro Autonomous Science and Technology Collaborative Contract (C.C.K., R.J.F) FX This work is supported by Burroughs Wellcome Fund Career Award at the Scientific Interface (C.L.), Miller Institute for Basic Research in Science, University of California, Berkeley (C.L.), and United States Army Research Laboratory under the Micro Autonomous Science and Technology Collaborative Contract (C.C.K., R.J.F). NR 36 TC 0 Z9 0 U1 1 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-5090-3762-9 PY 2016 BP 2128 EP 2134 PG 7 WC Computer Science, Artificial Intelligence; Robotics SC Computer Science; Robotics GA BG7XO UT WOS:000391921702044 ER PT J AU Lee, H Kwon, H Robinson, RM Donavanik, D Nothwang, WD Marathe, AR AF Lee, Hyungtae Kwon, Heesung Robinson, Ryan M. Donavanik, Daniel Nothwang, William D. Marathe, Amar R. GP IEEE TI Task-conversions for Integrating Human and Machine Perception in a Unified Task SO 2016 IEEE/RSJ INTERNATIONAL CONFERENCE ON INTELLIGENT ROBOTS AND SYSTEMS (IROS 2016) LA English DT Proceedings Paper CT IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS) CY OCT 09-14, 2016 CL Daejeon, SOUTH KOREA SP IEEE, RSJ AB The different strategies fir feature extraction and synthesis employed by humans and computers are often complementary, hence combining the two into an integrated object recognition system may considerably improve performance over either used in isolation. Rapid Serial Visual Presentation (RSVP) is one well-established technique that has shown promise integrating human perception into a machine perception system. In this paper, we apply computer vision techniques to image data filtered through human RSVP. We introduce "task conversions" to integrate the two modalities, applying the precise localization capabilities of computer vision with the detection capabilities of RSVP. We employ naive Bayesian fusion and a novel method, dynamic belief fusion (DBF), in a joint scheme as fusion approaches. Preliminary experiments demonstrate that DBF extracts complementary information from both human and machine sources to improve performance for both target classification and object detection. C1 [Lee, Hyungtae] Boor Allen Hamilton Inc, Mclean, VA 22102 USA. [Lee, Hyungtae; Kwon, Heesung; Robinson, Ryan M.; Donavanik, Daniel; Nothwang, William D.] Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. [Marathe, Amar R.] Army Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD USA. RP Lee, H (reprint author), Boor Allen Hamilton Inc, Mclean, VA 22102 USA.; Lee, H (reprint author), Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. EM lee_hyungtae@bah.com; heesung.kwon.civ@mail.mil; ryan.robinson14.ctr@mail.mil; daniel.donavanik.ctr@mail.mil; william.d.nothwang.civ@mail.mil; amar.marathe.civ@mail.mil FU U.S. Army Research Laboratory under a Director's Strategic Research Initiative entitled Heterogeneous Systems for Information Variable Environments (HIVE) [FY14-FY16] FX This project was supported by the U.S. Army Research Laboratory under a Director's Strategic Research Initiative entitled "Heterogeneous Systems for Information Variable Environments (HIVE)" from FY14-FY16. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 29 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-5090-3762-9 PY 2016 BP 2751 EP 2758 PG 8 WC Computer Science, Artificial Intelligence; Robotics SC Computer Science; Robotics GA BG7XO UT WOS:000391921702137 ER PT J AU Wigness, M Rogers, JG Navarro-Serment, LE Suppe, A Draper, BA AF Wigness, Maggie Rogers, John G., III Navarro-Serment, Luis Ernesto Suppe, Arne Draper, Bruce A. GP IEEE TI Reducing Adaptation Latency for Multi-Concept Visual Perception in Outdoor Environments SO 2016 IEEE/RSJ INTERNATIONAL CONFERENCE ON INTELLIGENT ROBOTS AND SYSTEMS (IROS 2016) LA English DT Proceedings Paper CT IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS) CY OCT 09-14, 2016 CL Daejeon, SOUTH KOREA SP IEEE, RSJ ID TERRAIN CLASSIFICATION; ROBOT NAVIGATION AB Multi-concept visual classification is emerging as a common environment perception technique, with applications in autonomous mobile robot navigation. Supervised visual classifiers are typically trained with large sets of images, hand annotated by humans with region boundary outlines followed by label assignment. This annotation is time consuming, and unfortunately, a change in environment requires new or additional labeling to adapt visual perception. The time is takes for a human to label new data is what we call adaptation latency. High adaptation latency is not simply undesirable but may be infeasible for scenarios with limited labeling time and resources. In this paper, we introduce a labeling framework to the environment perception domain that significantly reduces adaptation latency using unsupervised learning in exchange for a small amount of label noise. Using two real-world datasets we demonstrate the speed of our labeling framework, and its ability to collect environment labels that train high performing multi-concept classifiers. Finally, we demonstrate the relevance of this label collection process for visual perception as it applies to navigation in outdoor environments. C1 [Wigness, Maggie; Rogers, John G., III] US Army Res Lab, Adelphi, MD 20783 USA. [Navarro-Serment, Luis Ernesto; Suppe, Arne] Carnegie Mellon Univ, Inst Robot, Pittsburgh, PA 15213 USA. [Draper, Bruce A.] Colorado State Univ, Ft Collins, CO 80523 USA. RP Wigness, M (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. NR 36 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-5090-3762-9 PY 2016 BP 2784 EP 2791 PG 8 WC Computer Science, Artificial Intelligence; Robotics SC Computer Science; Robotics GA BG7XO UT WOS:000391921702142 ER PT J AU Ozaslan, T Mohta, K Keller, J Mulgaonkar, Y Taylor, CJ Kumar, V Wozencraft, JM Hood, T AF Ozaslan, Tolga Mohta, Kartik Keller, James Mulgaonkar, Yash Taylor, Camillo J. Kumar, Vijay Wozencraft, Jennifer M. Hood, Thomas GP IEEE TI Towards Fully Autonomous Visual Inspection of Dark Featureless Dam Penstocks using MAVs SO 2016 IEEE/RSJ INTERNATIONAL CONFERENCE ON INTELLIGENT ROBOTS AND SYSTEMS (IROS 2016) LA English DT Proceedings Paper CT IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS) CY OCT 09-14, 2016 CL Daejeon, SOUTH KOREA SP IEEE, RSJ AB In the last decade, multi-rotor Micro Aerial Vehicles (MAVs) have attracted great attention from robotics researchers. Offering affordable agility and maneuverability, multi-rotor aircrafts have become the most commonly used platforms for robotics applications. Amongst the most promising applications are inspection of power-lines, cell-towers, large and constrained infrastructures and precision agriculture. While GPS offers an easy solution for outdoor autonomy, using on-board sensors is the only solution for autonomy in constrained indoor environments. In this paper, we present our results on autonomous inspection of completely dark, featureless, symmetric dam penstocks using cameras and range sensors. We use a hex-rotor platform equipped with an IMU, four cameras and two lidars. One of the cameras tracks features on the walls using the on-board illumination to estimate the position along the tunnel axis unobservable to range sensors while all of the cameras are used for panoramic image construction. The two lidars estimate the remaining degrees of freedom (DOF). Outputs of the two estimators are fused using an Unscented Kalman Filter (UKF). A moderately trained operator defines waypoints using the Remote Control (RC). We demonstrate our results from Carters Dam, GA and Glen Canyon Dam, AZ which include panoramic images for cracks and rusty spot detection and 6-DOF estimation results with ground truth comparisons. To our knowledge ours is the only study that can autonomously inspect environments with no geometric cues and poor to no external illumination using MAVs. C1 [Ozaslan, Tolga; Mohta, Kartik; Keller, James; Mulgaonkar, Yash; Taylor, Camillo J.; Kumar, Vijay] Univ Penn, Grasp Lab, Philadelphia, PA 19104 USA. [Wozencraft, Jennifer M.; Hood, Thomas] USACE, Washington, DC USA. RP Ozaslan, T (reprint author), Univ Penn, Grasp Lab, Philadelphia,