FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Bohnet, JG Sawyer, BC Britton, JW Wall, ML Rey, AM Foss-Feig, M Bollinger, JJ AF Bohnet, Justin G. Sawyer, Brian C. Britton, Joseph W. Wall, Michael L. Rey, Ana Maria Foss-Feig, Michael Bollinger, John J. TI Quantum spin dynamics and entanglement generation with hundreds of trapped ions SO SCIENCE LA English DT Article ID RANGE INTERACTIONS; OPTICAL LATTICE; STATES; ATOMS; PROPAGATION; SIMULATION; NOISE AB Quantum simulation of spin models can provide insight into problems that are difficult or impossible to study with classical computers. Trapped ions are an established platform for quantum simulation, but only systems with fewer than 20 ions have demonstrated quantum correlations. We studied quantum spin dynamics arising from an engineered, homogeneous Ising interaction in a two-dimensional array of Be-9(+) ions in a Penning trap. We verified entanglement in spin-squeezed states of up to 219 ions, directly observing 4.0 +/- 0.9 decibels of spectroscopic enhancement, and observed states with non-Gaussian statistics consistent with oversqueezed states. The good agreement with ab initio theory that includes interactions and decoherence lays the groundwork for simulations of the transverse-field Ising model with variable-range interactions, which are generally intractable with classical methods. C1 [Bohnet, Justin G.; Sawyer, Brian C.; Britton, Joseph W.; Bollinger, John J.] NIST, Boulder, CO 80305 USA. [Sawyer, Brian C.] Georgia Tech Res Inst, Atlanta, GA 30332 USA. [Britton, Joseph W.; Foss-Feig, Michael] Army Res Lab, Adelphi, MD 20783 USA. [Wall, Michael L.; Rey, Ana Maria] Univ Colorado, NIST, Joint Inst Lab Astrophys, Boulder, CO 80309 USA. [Wall, Michael L.] Univ Colorado, Boulder, CO 80309 USA. [Rey, Ana Maria] Univ Colorado, Dept Phys, Boulder, CO 80309 USA. [Foss-Feig, Michael] Joint Quantum Inst, Gaithersburg, MD 20899 USA. [Foss-Feig, Michael] NIST, Gaithersburg, MD 20899 USA. RP Bohnet, JG; Bollinger, JJ (reprint author), NIST, Boulder, CO 80305 USA. EM justin.bohnet@nist.gov; jjb@nist.gov FU NSF [PHY 1521080]; JILA-NSF [PFC-1125844]; Army Research Office; Air Force Office of Scientific Research; Multidisciplinary University Research Initiative; National Research Council Research Associateship Award at NIST; NIST FX We thank D. Hume, J. Thompson, A. Keith, J. Schachenmayer, A. Safavi-Naini, M. Gaerttner, and M. Kastner for helpful discussions. Supported by NSF grant PHY 1521080, JILA-NSF grant PFC-1125844, the Army Research Office, and the Air Force Office of Scientific Research and its Multidisciplinary University Research Initiative (A.M.R.) and by a National Research Council Research Associateship Award at NIST (J.G.B., M.F.-F., and M.L.W.). All authors acknowledge financial support from NIST. This manuscript is the contribution of NIST and is not subject to U.S. copyright. NR 47 TC 17 Z9 17 U1 16 U2 28 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 0036-8075 EI 1095-9203 J9 SCIENCE JI Science PD JUN 10 PY 2016 VL 352 IS 6291 BP 1297 EP 1301 DI 10.1126/science.aad9958 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DO7ON UT WOS:000377972000035 PM 27284189 ER PT J AU Vijay, PV Soti, PR GangaRao, HVS Lampo, RG Clarkson, JD AF Vijay, P. V. Soti, Piyush R. GangaRao, Hota V. S. Lampo, Richard G. Clarkson, John D. TI Design and evaluation of an integrated FRP composite wicket gate SO COMPOSITE STRUCTURES LA English DT Article DE Cellular FRP deck; Sandwich panel; Deck stiffness; Hydraulic structure; Wicket gate ID PERFORMANCE AB Hydraulic gates need to be light-weight, corrosion-resistant, maintenance-free, and durable with high endurance under fatigue loads. All of these requirements could be challenges to be met using conventional materials like steel and concrete. However, with the emergence of advanced Fiber Reinforced Polymer (FRP) composites for waterway structures, it has now been possible to achieve all of these physical and performance requirements in a cost-effective manner. Due to their lightness, excellent corrosion and wear resistance along with superior thermo-mechanical properties, FRPs have emerged as one of the best alternatives in the field of civil infrastructure. This paper covers several aspects of the design, manufacturing, testing, analysis, and field implementation of a novel integrated FRP wicket gate in Mississippi River lock and dam. The cellular FRP panel with foam core and integrated stiffening and fastening components has been analyzed to compute the bending stiffness both theoretically and experimentally and a good correlation has been obtained. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Vijay, P. V.; GangaRao, Hota V. S.] W Virginia Univ, Constructed Facil Ctr, Dept CEE, Morgantown, WV 26506 USA. [Soti, Piyush R.] W Virginia Univ, Dept CEE, Morgantown, WV 26506 USA. [Lampo, Richard G.] US Army Corps Engineers, Champaign, IL 61826 USA. [Clarkson, John D.] US Army Corps Engineers, Huntington, WV 25701 USA. RP Vijay, PV (reprint author), W Virginia Univ, Constructed Facil Ctr, Dept CEE, Morgantown, WV 26506 USA. EM p.vijay@mail.wvu.edu FU U.S. Army Corps of Engineers (USACE) FX The writers gratefully acknowledge the financial support from U.S. Army Corps of Engineers (USACE). Support from all the engineering and supporting staff of USACE and Rock Island lock and dam site is sincerely acknowledged. NR 29 TC 2 Z9 2 U1 3 U2 16 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0263-8223 EI 1879-1085 J9 COMPOS STRUCT JI Compos. Struct. PD JUN 10 PY 2016 VL 145 BP 149 EP 161 DI 10.1016/j.compstruct.2016.01.093 PG 13 WC Materials Science, Composites SC Materials Science GA DI4PO UT WOS:000373482000014 ER PT J AU Lisenkov, I Tyberkevych, V Levin-Pompetzki, L Bankowski, E Meitzler, T Nikitov, S Slavin, A AF Lisenkov, Ivan Tyberkevych, Vasyl Levin-Pompetzki, Luke Bankowski, Elena Meitzler, Thomas Nikitov, Sergey Slavin, Andrei TI y Interaction of Microwave Photons with Nanostructured Magnetic Metasurfaces SO PHYSICAL REVIEW APPLIED LA English DT Article ID ELECTROMAGNETIC-FIELDS; METAMATERIALS; RESONANCES AB We develop a theoretical formalism for the description of the interaction of microwave photons with a thin (compared to the photon wavelength) magnetic metasurface comprised of dipolarly interacting nanoscale magnetic elements. We derive a scattering matrix describing the processes of photon transmission and reflection at the metasurface boundary. As an example of the use of the developed formalism, we demonstrate that the introduction of a magnetic metasurface inside a microstrip electromagnetic waveguide quantitatively changes the dispersion relation of the fundamental waveguide mode, opening a nonpropagation frequency band gap in the waveguide spectrum. The frequency position and the width of the band gap are dependent on the waveguide thickness and can be controlled dynamically by switching the magnetic ground state of the metasurface. For sufficiently thin waveguides, the position of the band gap is shifted from the resonance absorption frequency of the metasurface. In such a case, the magnetic metasurface inside a waveguide works as an efficient reflector, as the energy absorption in the metasurface is small, and most of the electromagnetic energy inside the nonpropagation band gap is reflected. C1 [Lisenkov, Ivan; Tyberkevych, Vasyl; Levin-Pompetzki, Luke; Slavin, Andrei] Oakland Univ, Dept Phys, 2200 North Squirrel Rd, Rochester, MI 48309 USA. [Lisenkov, Ivan; Nikitov, Sergey] RAS, Kotelnikov Inst Radio Engn & Elect, 11-7 Mokhovaya, Moscow 125009, Moscow, Russia. [Bankowski, Elena; Meitzler, Thomas] US Army TARDEC, Warren, MI 48397 USA. [Nikitov, Sergey] Moscow Inst Phys & Technol, 9 Inst Skij, Dolgoprudnyi 141700, Moscow Region, Russia. [Nikitov, Sergey] Saratov NG Chernyshevskii State Univ, 83 Astrakhanskaya, Saratov 410012, Saratov, Russia. RP Lisenkov, I (reprint author), Oakland Univ, Dept Phys, 2200 North Squirrel Rd, Rochester, MI 48309 USA.; Lisenkov, I (reprint author), RAS, Kotelnikov Inst Radio Engn & Elect, 11-7 Mokhovaya, Moscow 125009, Moscow, Russia. EM ivan.lisenkov@phystech.edu RI Meitzler, Thomas/D-1065-2017 FU National Science Foundation of the USA [ECCS-1305586]; U.S. Army [TARDEC, RDECOM]; DARPA grant "Coherent Information Transduction between Photons, Magnons, and Electric Charge Carriers"; Center for NanoFerroic Devices; Nanoelectronics Research Initiative; Russian Scientific Foundation [14-19-00760] FX This work is supported in part by Grant No. ECCS-1305586 from the National Science Foundation of the USA, by the U.S. Army Contract No. TARDEC, RDECOM, by the DARPA grant "Coherent Information Transduction between Photons, Magnons, and Electric Charge Carriers," and by the Center for NanoFerroic Devices and the Nanoelectronics Research Initiative. I.L. and S.N. acknowledge the Russian Scientific Foundation Grant No. 14-19-00760 for financial support. NR 40 TC 0 Z9 0 U1 5 U2 14 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2331-7019 J9 PHYS REV APPL JI Phys. Rev. Appl. PD JUN 9 PY 2016 VL 5 IS 6 AR 064005 DI 10.1103/PhysRevApplied.5.064005 PG 11 WC Physics, Applied SC Physics GA DO1AP UT WOS:000377510900002 ER PT J AU Kaplan, D Mills, K Lee, J Torrel, S Swaminathan, V AF Kaplan, D. Mills, K. Lee, J. Torrel, S. Swaminathan, V. TI Excitation intensity dependent photoluminescence of annealed two-dimensional MoS2 grown by chemical vapor deposition SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID MONOLAYER MOLYBDENUM-DISULFIDE; LAYER MOS2; TRANSPORT-PROPERTIES; EXFOLIATED MOS2; MONO LAYER; SEMICONDUCTORS; DEFECTS; SURFACES; EXCITONS; TRIONS AB Here, we present detailed results of Raman and photoluminescence (PL) characterization of monolayers of MoS2 grown by chemical vapor deposition (CVD) on SiO2/Si substrates after thermal annealing at 150 degrees C, 200 degrees C, and 250 degrees C in an argon atmosphere. In comparison to the as-grown monolayers, annealing in the temperature range of 150-250 degrees C brings about significant changes in the band edge luminescence. It is observed that annealing at 150 degrees C gives rise to a 100-fold increase in the PL intensity and produces a strong band at 1.852 eV attributed to a free-to-bound transition that dominates over the band edge excitonic luminescence. This band disappears for the higher annealing temperatures. The improvement in PL after the 200 degrees C anneal is reduced in comparison to that obtained after the 150 degrees C anneal; this is suggested to arise from a decrease in the non-radiative lifetime caused by the creation of sulfur di-vacancies. Annealing at 250 degrees C degrades the PL in comparison to the as-grown sample because of the onset of disorder/decomposition of the sample. It is clear that the PL features of the CVD-grown MoS2 monolayer are profoundly affected by thermal annealing in Ar atmosphere. However, further detailed studies are needed to identify, unambiguously, the role of native defects and/or adsorbed species in defining the radiative channels in annealed samples so that the beneficial effect of improvement in the optical efficiency of the MoS2 monolayers can be leveraged for various device applications. C1 [Kaplan, D.; Swaminathan, V.] US Army RDECOM ARDEC, Fuze Precis Armaments & Technol Directorate, Picatinny Arsenal, NJ 07806 USA. [Mills, K.] US Army RDECOM ARDEC, Energet Warheads & Mfg Technol Directorate, Picatinny Arsenal, NJ 07806 USA. [Lee, J.] Agcy Def Dev, POB 35, Yuseong 305600, Daejeon, South Korea. [Torrel, S.] Rutgers State Univ, Dept Mat Sci & Engn, Piscataway, NJ 08854 USA. [Lee, J.] US Army RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA. RP Kaplan, D (reprint author), US Army RDECOM ARDEC, Fuze Precis Armaments & Technol Directorate, Picatinny Arsenal, NJ 07806 USA. NR 47 TC 2 Z9 2 U1 24 U2 41 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD JUN 7 PY 2016 VL 119 IS 21 AR 214301 DI 10.1063/1.4948662 PG 9 WC Physics, Applied SC Physics GA DQ0WS UT WOS:000378923100017 ER PT J AU Sarney, WL Svensson, SP Lin, Y Donetsky, D Shterengas, L Kipshidze, G Belenky, G AF Sarney, W. L. Svensson, S. P. Lin, Y. Donetsky, D. Shterengas, L. Kipshidze, G. Belenky, G. TI Extremely small bandgaps, engineered by controlled multi-scale ordering in InAsSb SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID STRAINED-LAYER SUPERLATTICES; VAPOR-PHASE EPITAXY; CELL CONFIGURATION; INAS1-XSBX; PROPOSAL; ALLOYS; GROWTH; FILMS; GAINP AB The relationship between the effective bandgap and the crystalline structure in ordered InAsSb material has been studied. Modulation of the As/Sb ratio was induced along the growth direction during molecular beam epitaxy, producing a strained layer superlattice. To enable the use of concentration ratios near unity in both layers in the period, the structures were grown with negligible net strain on a virtual substrate with a lattice constant considerably larger than that of GaSb. The bandgap line-up of InAsSb layers with different compositions is such that a type II superlattice is formed, which exhibits smaller bandgaps than either of the two constituents. It can also be smaller than the possible minimum direct-bandgap of the alloy. From observations of CuPt ordering in bulk layers with small amounts of strain of both signs, we postulate that strain is the main driving force for atomic ordering in InAsSb. Because the modulated structures exhibit small but opposing amounts of strain, both layers in the period exhibit ordering at the atomic scale throughout the structure. Since the strain can be controlled, the ordering can be controlled and sustained for arbitrary thick layers, unlike the situation in uniform bulk layers where the residual strain eventually leads to dislocation formation. This offers a unique way of using ordering at two different scales to engineer the band-structure. Published by AIP Publishing. C1 [Sarney, W. L.; Svensson, S. P.] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Lin, Y.; Donetsky, D.; Shterengas, L.; Kipshidze, G.; Belenky, G.] SUNY Stony Brook, Dept Elect & Comp Engn, Stony Brook, NY 11794 USA. RP Sarney, WL (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. OI LIN, YOUXI/0000-0002-9092-2302 FU U.S. National Science Foundation [DMR1160843]; U.S. Army Research Office [W911NF-16-20053] FX This work was supported by the U.S. National Science Foundation through Grant No. DMR1160843 and by the U.S. Army Research Office through Award W911NF-16-20053. NR 24 TC 1 Z9 1 U1 5 U2 10 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD JUN 7 PY 2016 VL 119 IS 21 AR 215704 DI 10.1063/1.4952754 PG 6 WC Physics, Applied SC Physics GA DQ0WS UT WOS:000378923100051 ER PT J AU Kostereva, NV Wang, Y Fletcher, DR Unadkat, JV Schnider, JT Komatsu, C Yang, Y Stolz, DB Davis, MR Plock, JA Gorantla, VS AF Kostereva, Nataliya V. Wang, Yong Fletcher, Derek R. Unadkat, Jignesh V. Schnider, Jonas T. Komatsu, Chiaki Yang, Yang Stolz, Donna B. Davis, Michael R. Plock, Jan A. Gorantla, Vijay S. TI IGF-1 and Chondroitinase ABC Augment Nerve Regeneration after Vascularized Composite Limb Allotransplantation SO PLOS ONE LA English DT Article ID GROWTH-FACTOR-I; MUSCLE REINNERVATION; AXONAL REGENERATION; PROTEOGLYCANS; EXPRESSION; SYSTEM; GLYCOSAMINOGLYCANS; CELLS; FK506 AB Impaired nerve regeneration and inadequate recovery of motor and sensory function following peripheral nerve repair remain the most significant hurdles to optimal functional and quality of life outcomes in vascularized tissue allotransplantation (VCA). Neurotherapeutics such as Insulin-like Growth Factor-1 (IGF-1) and chondroitinase ABC (CH) have shown promise in augmenting or accelerating nerve regeneration in experimental models and may have potential in VCA. The aim of this study was to evaluate the efficacy of low dose IGF-1, CH or their combination (IGF-1+CH) on nerve regeneration following VCA. We used an allogeneic rat hind limb VCA model maintained on low-dose FK506 (tacrolimus) therapy to prevent rejection. Experimental animals received neurotherapeutics administered intraoperatively as multiple intraneural injections. The IGF-1 and IGF-1+CH groups received daily IGF-1 (intramuscular and intraneural injections). Histomorphometry and immunohistochemistry were used to evaluate outcomes at five weeks. Overall, compared to controls, all experimental groups showed improvements in nerve and muscle (gastrocnemius) histomorphometry. The IGF-1 group demonstrated superior distal regeneration as confirmed by Schwann cell (SC) immunohistochemistry as well as some degree of extrafascicular regeneration. IGF-1 and CH effectively promote nerve regeneration after VCA as confirmed by histomorphometric and immunohistochemical outcomes. C1 [Kostereva, Nataliya V.; Wang, Yong; Fletcher, Derek R.; Unadkat, Jignesh V.; Schnider, Jonas T.; Komatsu, Chiaki; Yang, Yang; Plock, Jan A.; Gorantla, Vijay S.] Univ Pittsburgh, Dept Plast Surg, Thomas E Starzl Transplant Inst, Pittsburgh, PA USA. [Kostereva, Nataliya V.; Plock, Jan A.; Gorantla, Vijay S.] Univ Pittsburgh, McGowan Inst Regenerat Med, Pittsburgh, PA USA. [Wang, Yong] East Hosp Shanghai, Dept Trauma Surg, Shanghai, Peoples R China. [Stolz, Donna B.] Univ Pittsburgh, Ctr Biol Imaging, Pittsburgh, PA USA. [Davis, Michael R.] US Army, Inst Surg Res, San Antonio Mil Med Ctr, 3698 Chambers Rd, San Antonio, TX USA. [Fletcher, Derek R.] Univ Penn, Div Plast Surg, Philadelphia, PA 19104 USA. [Schnider, Jonas T.] Univ Hosp Bern, Inselspital, Dept Plast & Hand Surg, CH-3010 Bern, Switzerland. [Yang, Yang] Fourth Mil Med Univ, Xijing Hosp, Dept Plast & Reconstruct Surg, Xian 710032, Xincheng, Peoples R China. [Plock, Jan A.] Univ Zurich Hosp, Div Plast & Hand Surg, CH-8091 Zurich, Switzerland. RP Gorantla, VS (reprint author), Univ Pittsburgh, Dept Plast Surg, Thomas E Starzl Transplant Inst, Pittsburgh, PA USA.; Gorantla, VS (reprint author), Univ Pittsburgh, McGowan Inst Regenerat Med, Pittsburgh, PA USA. EM gorantlavs@upmc.edu FU Department of Defense (Congressionally Directed Medical Research Programs) [W81XWH-11-2-0215] FX The study was supported by a generous grant by the Department of Defense (Congressionally Directed Medical Research Programs)- Grant # W81XWH-11-2-0215, PI: Vijay Gorantla (URL: http://cdmrp.army.mil). The sponsors had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 31 TC 0 Z9 0 U1 1 U2 1 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUN 7 PY 2016 VL 11 IS 6 AR e0156149 DI 10.1371/journal.pone.0156149 PG 17 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DO1TC UT WOS:000377561000008 PM 27272754 ER PT J AU Petrache, CM Guo, S Ayangeakaa, AD Garg, U Matta, JT Nayak, BK Patel, D Carpenter, MP Chiara, CJ Janssens, RVF Kondev, FG Lauritsen, T Seweryniak, D Zhu, S Ghugre, SS Palit, R AF Petrache, C. M. Guo, S. Ayangeakaa, A. D. Garg, U. Matta, J. T. Nayak, B. K. Patel, D. Carpenter, M. P. Chiara, C. J. Janssens, R. V. F. Kondev, F. G. Lauritsen, T. Seweryniak, D. Zhu, S. Ghugre, S. S. Palit, R. TI Triaxiality and exotic rotations at high spins in Ce-134 SO PHYSICAL REVIEW C LA English DT Article ID COINCIDENCE DATA SETS; MASS REGION; BANDS; STATES; CE; COLLECTIVITY; EXCITATIONS; ISOTOPES; ND-136; MODEL AB High-spin states in Ce-134 have been investigated using the Cd-116(Ne-22,4n) reaction and the Gammasphere array. The level scheme has been extended to an excitation energy of similar to 30 MeV and spin similar to 54 (h) over bar. Two new dipole bands and four new sequences of quadrupole transitions were identified. Several new transitions have been added to a number of known bands. One of the strongly populated dipole bands was revised and placed differently in the level scheme, resolving a discrepancy between experiment and model calculations reported previously. Configurations are assigned to the observed bands based on cranked Nilsson-Strutinsky calculations. A coherent understanding of the various excitations, both at low and high spins, is thus obtained, supporting an interpretation in terms of coexistence of stable triaxial, highly deformed, and superdeformed shapes up to very high spins. Rotations around different axes of the triaxial nucleus, and sudden changes of the rotation axis in specific configurations, are identified, further elucidating the nature of high-spin collective excitations in the A = 130 mass region. C1 [Petrache, C. M.; Guo, S.] Univ Paris Saclay, CNRS IN2P3, Ctr Sci Nucl & Sci Mat, Batiment 104-108, F-91405 Orsay, France. [Ayangeakaa, A. D.; Garg, U.; Matta, J. T.; Nayak, B. K.; Patel, D.] Univ Notre Dame, Dept Phys, Notre Dame, IN 46556 USA. [Ayangeakaa, A. D.; Carpenter, M. P.; Chiara, C. J.; Janssens, R. V. F.; Lauritsen, T.; Seweryniak, D.; Zhu, S.] Argonne Natl Lab, Div Phys, Argonne, IL 60439 USA. [Chiara, C. J.] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA. [Kondev, F. G.] Argonne Natl Lab, Nucl Engn Div, 9700 S Cass Ave, Argonne, IL 60439 USA. [Ghugre, S. S.] UGC DAE Consortium Sci Res, Kolkata 700098, India. [Palit, R.] Tata Inst Fundamental Res, Homi Bhabha Rd, Bombay 400005, Maharashtra, India. [Palit, R.] Univ Notre Dame, Joint Inst Nucl Astrophys, Notre Dame, IN 46556 USA. [Matta, J. T.] Oak Ridge Natl Lab, Div Phys, Oak Ridge, TN 37830 USA. [Nayak, B. K.] Bhabha Atom Res Ctr, Div Nucl Phys, Bombay 400085, Maharashtra, India. [Patel, D.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. [Chiara, C. J.] US Army Res Lab, Adelphi, MD 20783 USA. RP Petrache, CM (reprint author), Univ Paris Saclay, CNRS IN2P3, Ctr Sci Nucl & Sci Mat, Batiment 104-108, F-91405 Orsay, France. RI Palit, Rudrajyoti/F-5185-2012 FU US National Science Foundation [PHY07-58100, PHY-0822648, PHY-1068192, PHY-1419765]; US Department of Energy, Office of Nuclear Physics [DE-FG02-94ER40834, DE-AC02-06CH11357] FX C.M.P. expresses his gratitude to Prof. I. Ragnarsson for providing the CNS codes, for the training on how to use them, and for enlightening comments on the theoretical interpretation of the results. This work has been supported in part by the US National Science Foundation (Grants No. PHY07-58100, No. PHY-0822648, No. PHY-1068192, and No. PHY-1419765), the US Department of Energy, Office of Nuclear Physics, under Grant No. DE-FG02-94ER40834 (UM), and Contract No. DE-AC02-06CH11357 (ANL). This research used resources of ANL's ATLAS facility, which is a DOE Office of Science User Facility. NR 36 TC 1 Z9 1 U1 3 U2 5 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2469-9985 EI 2469-9993 J9 PHYS REV C JI Phys. Rev. C PD JUN 6 PY 2016 VL 93 IS 6 AR 064305 DI 10.1103/PhysRevC.93.064305 PG 18 WC Physics, Nuclear SC Physics GA DN8AW UT WOS:000377302300002 ER PT J AU Giersing, BK Modjarrad, K Kaslow, DC Okwo-Bele, JM Moorthy, VS AF Giersing, Birgitte K. Modjarrad, Kayvon Kaslow, David C. Okwo-Bele, Jean-Marie Moorthy, Vasee S. TI The 2016 Vaccine Development Pipeline: A special issue from the World Health Organization Product Development for Vaccine Advisory Committee (PDVAC) Preface SO VACCINE LA English DT Editorial Material C1 [Giersing, Birgitte K.; Okwo-Bele, Jean-Marie; Moorthy, Vasee S.] WHO, CH-1211 Geneva, Switzerland. [Modjarrad, Kayvon] Walter Reed Army Inst Res, Silver Spring, MD USA. [Kaslow, David C.] PATH, Seattle, WA USA. RP Giersing, BK (reprint author), WHO, CH-1211 Geneva, Switzerland. FU World Health Organization [001] NR 0 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD JUN 3 PY 2016 VL 34 IS 26 SI SI BP 2863 EP 2864 DI 10.1016/j.vaccine.2016.04.041 PG 2 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA DP3AQ UT WOS:000378365200001 PM 27108194 ER PT J AU Giersing, BK Modjarrad, K Kaslow, DC Moorthy, VS AF Giersing, Birgitte K. Modjarrad, Kayvon Kaslow, David C. Moorthy, Vasee S. CA WHO Prod Dev Vaccines Advisory Com TI Report from the World Health Organization's Product Development for Vaccines Advisory Committee (PDVAC) meeting, Geneva, 7-9th Sep 2015 SO VACCINE LA English DT Article DE Vaccine; Candidate; Product development; PPC; LMIC ID DEVELOPING-COUNTRIES; DIARRHEAL DISEASE; DOUBLE-BLIND; IMMUNOGENICITY; EFFICACY; CHILDREN; SAFETY; TRIAL AB There are more vaccines in development, against a greater number of pathogens, than ever before. A challenge with this exceptional level of activity and investment is how to select and resource the most promising approaches to have the most significant impact on public health. The WHO Product Development for Vaccines Advisory Committee (PDVAC) was established in 2014 to provide strategic advice and recommendations to WHO for vaccines in clinical development that could have a significant impact on public health in low and middle income countries. On 7-9th September 2015, PDVAC was convened for the second time, when the committee reviewed vaccine developments in 24 disease areas. This report summarises the key recommendations from that consultation. (C) 2016 World Health Organization; licensee Elsevier Ltd. C1 [Giersing, Birgitte K.; Moorthy, Vasee S.] WHO, Initiat Vaccine Res, 20 Ave Appia, CH-1211 Geneva 27, Switzerland. [Modjarrad, Kayvon] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. [Kaslow, David C.] PATH, Seattle, WA 98109 USA. RP Moorthy, VS (reprint author), WHO, Initiat Vaccine Res, 20 Ave Appia, CH-1211 Geneva 27, Switzerland. EM moorthyv@who.int FU World Health Organization [001] NR 12 TC 3 Z9 3 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD JUN 3 PY 2016 VL 34 IS 26 SI SI BP 2865 EP 2869 DI 10.1016/j.vaccine.2016.02.078 PG 5 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA DP3AQ UT WOS:000378365200002 PM 26993336 ER PT J AU Giersing, BK Dastgheyb, SS Modjarrad, K Moorthy, V AF Giersing, Birgitte K. Dastgheyb, Sana S. Modjarrad, Kayvon Moorthy, Vasee TI Status of vaccine research and development of vaccines for Staphylococcus aureus SO VACCINE LA English DT Article DE Methicillin-resistant S. aureus (MRSA); Skin and soft tissue infections; Multi-antigen approaches; Vaccine; Antibody ID UNITED-STATES; S. AUREUS; INFECTIONS; DISEASE; IMMUNOGENICITY; MORTALITY; EFFICACY; PROGRESS; PROFILE; BURDEN AB Staphylococcus aureus is a highly versatile gram positive bacterium that is resident as an asymptomatic colonizer on the skin and in the nasopharynx of approximately 30% of individuals. Nasopharyngeal colonization is a risk for acquiring S. aureus infections, which can cause a range of clinical symptoms that are commonly associated with skin and soft-tissue infections. The emergence of S. aureus strains that are highly resistant to antimicrobials has recently become a major public health concern. In low-income countries the incidence of S. aureus disease is highest in neonates and children up to one year of age and mortality rates are estimated to be up to 50%. In the United States, S. aureus infection accounts for approximately 300,000 hospitalizations per year. A vaccine against multi-drug resistant S. aureus, therefore, is urgently needed. Two vaccine candidates have previously been evaluated in late-stage clinical trials but have not demonstrated efficacy. At present, one vaccine candidate and two monoclonal antibody are undergoing clinical evaluation in target groups at high risk for S. aureus infection. This review provides an overview of current vaccine development efforts and presents the major technical and regulatory challenges to developing a licensed S. aureus vaccine. (C) 2016 World Health Organization; licensee Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org(licensesiby/3.0/). C1 [Giersing, Birgitte K.; Moorthy, Vasee] WHO, Initiat Vaccine Res, 20 Ave Appia, CH-1211 Geneva 27, Switzerland. [Dastgheyb, Sana S.] Thomas Jefferson Univ, Sidney Kimmel Med Coll, Philadelphia, PA 19107 USA. [Modjarrad, Kayvon] Walter Reed Army Inst Res, Bethesda, MD USA. RP Giersing, BK (reprint author), WHO, Initiat Vaccine Res, 20 Ave Appia, CH-1211 Geneva 27, Switzerland. EM giersingb@who.int OI Dastgheyb, Sana/0000-0001-8275-1614 FU World Health Organization [001] NR 38 TC 5 Z9 5 U1 12 U2 13 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD JUN 3 PY 2016 VL 34 IS 26 SI SI BP 2962 EP 2966 DI 10.1016/j.vaccine.2016.03.110 PG 5 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA DP3AQ UT WOS:000378365200020 PM 27105559 ER PT J AU Robb, ML Eller, LA Kibuuka, H Rono, K Maganga, L Nitayaphan, S Kroon, E Sawe, FK Sinei, S Sriplienchan, S Jagodzinski, LL Malia, J Manak, M de Souza, MS Tovanabutra, S Sanders-Buell, E Rolland, M Dorsey-Spitz, J Eller, MA Milazzo, M Li, Q Lewandowski, A Wu, H Swann, E O'Connell, RJ Peel, S Dawson, P Kim, JH Michael, NL AF Robb, Merlin L. Eller, Leigh A. Kibuuka, Hannah Rono, Kathleen Maganga, Lucas Nitayaphan, Sorachai Kroon, Eugene Sawe, Fred K. Sinei, Samuel Sriplienchan, Somchai Jagodzinski, Linda L. Malia, Jennifer Manak, Mark de Souza, Mark S. Tovanabutra, Sodsai Sanders-Buell, Eric Rolland, Morgane Dorsey-Spitz, Julie Eller, Michael A. Milazzo, Mark Li, Qun Lewandowski, Andrew Wu, Hao Swann, Edith O'Connell, Robert J. Peel, Sheila Dawson, Peter Kim, Jerome H. Michael, Nelson L. CA RV 217 Study Team TI Prospective Study of Acute HIV-1 Infection in Adults in East Africa and Thailand SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID VIRUS TYPE-1 INFECTION; T-CELL-ACTIVATION; VIRAL LOAD; SET-POINT; ANTIRETROVIRAL THERAPY; RNA LEVELS; 1ST YEAR; TRANSMISSION; DYNAMICS; PROGRESSION AB BACKGROUND Acute human immunodeficiency virus type 1 (HIV-1) infection is a major contributor to transmission of HIV-1. An understanding of acute HIV-1 infection may be important in the development of treatment strategies to eradicate HIV-1 or achieve a functional cure. METHODS We performed twice-weekly qualitative plasma HIV-1 RNA nucleic acid testing in 2276 volunteers who were at high risk for HIV-1 infection. For participants in whom acute HIV-1 infection was detected, clinical observations, quantitative measurements of plasma HIV-1 RNA levels (to assess viremia) and HIV antibodies, and results of immuno-phenotyping of lymphocytes were obtained twice weekly. RESULTS Fifty of 112 volunteers with acute HIV-1 infection had two or more blood samples collected before HIV-1 antibodies were detected. The median peak viremia (6.7 log 10 copies per milliliter) occurred 13 days after the first sample showed reactivity on nucleic acid testing. Reactivity on an enzyme immunoassay occurred at a median of 14 days. The nadir of viremia (4.3 log 10 copies per milliliter) occurred at a median of 31 days and was nearly equivalent to the viral-load set point, the steady-state viremia that persists durably after resolution of acute viremia (median plasma HIV-1 RNA level, 4.4 log 10 copies per milliliter). The peak viremia and downslope were correlated with the viralload set point. Clinical manifestations of acute HIV-1 infection were most common just before and at the time of peak viremia. A median of one symptom of acute HIV-1 infection was recorded at a median of two study visits, and a median of one sign of acute HIV-1 infection was recorded at a median of three visits. CONCLUSIONS The viral-load set point occurred at a median of 31 days after the first detection of plasma viremia and correlated with peak viremia. Few symptoms and signs were observed during acute HIV-1 infection, and they were most common before peak viremia. (Funded by the Department of Defense and the National Institute of Allergy and Infectious Diseases.) C1 [Robb, Merlin L.; Eller, Leigh A.; Jagodzinski, Linda L.; Malia, Jennifer; Manak, Mark; Tovanabutra, Sodsai; Sanders-Buell, Eric; Rolland, Morgane; Dorsey-Spitz, Julie; Eller, Michael A.; Milazzo, Mark; Li, Qun; Peel, Sheila; Kim, Jerome H.; Michael, Nelson L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Robb, Merlin L.; Eller, Leigh A.; Manak, Mark; Tovanabutra, Sodsai; Sanders-Buell, Eric; Rolland, Morgane; Dorsey-Spitz, Julie; Eller, Michael A.; Milazzo, Mark] Henry M Jackson Fdn Adv Mil Med, Rockville, MD USA. [Swann, Edith] NIAID, Div Aids, NIH, Rockville, MD USA. [Lewandowski, Andrew; Wu, Hao; Dawson, Peter] Emmes, Rockville, MD USA. [Kibuuka, Hannah] Makerere Univ, Walter Reed Project, Kampala, Uganda. [Rono, Kathleen; Sawe, Fred K.; Sinei, Samuel] Walter Reed Project, Kericho, Kenya. [Maganga, Lucas] Mbeya Med Res Ctr, Mbeya, Tanzania. [Nitayaphan, Sorachai; Kroon, Eugene; Sriplienchan, Somchai; de Souza, Mark S.; O'Connell, Robert J.] Armed Forces Res Inst Med Sci, Bangkok, Thailand. [Kroon, Eugene; de Souza, Mark S.] SEARCH, Thai Red Cross AIDS Res Ctr, Bangkok, Thailand. [Kim, Jerome H.] Int Vaccine Inst, Seoul, South Korea. RP Robb, ML (reprint author), US Mil HIV Res Program, 6720A Rockledge Dr, Bethesda, MD 20817 USA. EM mrobb@hivresearch.org OI Manak, Mark /0000-0002-9217-9129 FU Department of Defense; National Institute of Allergy and Infectious Diseases FX Funded by the Department of Defense and the National Institute of Allergy and Infectious Diseases. NR 39 TC 12 Z9 12 U1 2 U2 3 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 EI 1533-4406 J9 NEW ENGL J MED JI N. Engl. J. Med. PD JUN 2 PY 2016 VL 374 IS 22 BP 2120 EP 2130 DI 10.1056/NEJMoa1508952 PG 11 WC Medicine, General & Internal SC General & Internal Medicine GA EB2RP UT WOS:000387209900005 PM 27192360 ER PT J AU Piccinini, N Lambert, D West, BJ Bologna, M Grigolini, P AF Piccinini, Nicola Lambert, David West, Bruce J. Bologna, Mauro Grigolini, Paolo TI Nonergodic complexity management SO PHYSICAL REVIEW E LA English DT Article ID HUMAN COGNITION; 1/F NOISE; CRITICALITY; INFORMATION; NETWORKS; INTERMITTENCY; AVALANCHES; EMERGENCE; BREAKDOWN; DYNAMICS AB Linear response theory, the backbone of nonequilibrium statistical physics, has recently been extended to explain how and why nonergodic renewal processes are insensitive to simple perturbations, such as in habituation. It was established that a permanent correlation results between an external stimulus and the response of a complex system generating nonergodic renewal processes, when the stimulus is a similar nonergodic process. This is the principle of complexity management, whose proof relies on ensemble distribution functions. Herein we extend the proof to the nonergodic case using time averages and a single time series, hence making it usable in real life situations where ensemble averages cannot be performed because of the very nature of the complex systems being studied. C1 [Piccinini, Nicola; Lambert, David; Grigolini, Paolo] Univ N Texas, Ctr Nonlinear Sci, POB 311427, Denton, TX 76203 USA. [West, Bruce J.] US Army, Informat Sci Directorate, Res Off, Res Triangle Pk, NC 27709 USA. [Bologna, Mauro] Univ Tarapaca, Inst Alta Invest, Casilla 6-D, Arica, Chile. RP Piccinini, N (reprint author), Univ N Texas, Ctr Nonlinear Sci, POB 311427, Denton, TX 76203 USA. FU Welch Foundation [B-1577]; Army Research Office [W911NF-15-1-0245] FX N.P., D.L., and G.P. thank Welch Foundation for financial support through Grant No. B-1577 and Army Research Office for financial support through Grant No. W911NF-15-1-0245. NR 53 TC 1 Z9 1 U1 3 U2 5 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2470-0045 EI 2470-0053 J9 PHYS REV E JI Phys. Rev. E PD JUN 2 PY 2016 VL 93 IS 6 AR 062301 DI 10.1103/PhysRevE.93.062301 PG 7 WC Physics, Fluids & Plasmas; Physics, Mathematical SC Physics GA DN3ZA UT WOS:000377001600003 PM 27415274 ER PT J AU Yu, AB Zacks, JM AF Yu, Alfred B. Zacks, Jeffrey M. TI How are bodies special? Effects of body features on spatial reasoning SO QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY LA English DT Article DE Perspective taking; Spatial transformations; Mental imagery ID MENTAL ROTATION; INVERSION; TRANSFORMATIONS; PERCEPTION; FACE; MOVEMENTS; OBJECTS; AREA AB Embodied views of cognition argue that cognitive processes are influenced by bodily experience. This implies that when people make spatial judgments about human bodies, they bring to bear embodied knowledge that affects spatial reasoning performance. Here, we examined the specific contribution to spatial reasoning of visual features associated with the human body. We used two different tasks to elicit distinct visuospatial transformations: object-based transformations, as elicited in typical mental rotation tasks, and perspective transformations, used in tasks in which people deliberately adopt the egocentric perspective of another person. Body features facilitated performance in both tasks. This result suggests that observers are particularly sensitive to the presence of a human head and body, and that these features allow observers to quickly recognize and encode the spatial configuration of a figure. Contrary to prior reports, this facilitation was not related to the transformation component of task performance. These results suggest that body features facilitate task components other than spatial transformation, including the encoding of stimulus orientation. C1 [Yu, Alfred B.] Army Res Lab, Aberdeen Proving Ground, MD USA. [Yu, Alfred B.; Zacks, Jeffrey M.] Washington Univ, Dept Psychol, 1 Brookings Dr, St Louis, MO 63130 USA. RP Zacks, JM (reprint author), Washington Univ, Dept Psychol, 1 Brookings Dr, St Louis, MO 63130 USA. EM jzacks@wustl.edu FU United States Department of Defense Science, Mathematics, and Research for Transformation (SMART) scholarship; NIMH [RO1MH70674]; NIA [R01AG031150] FX This work was supported by a United States Department of Defense Science, Mathematics, and Research for Transformation (SMART) scholarship to the first author, and NIMH grant [grant number RO1MH70674] and a NIA grant [grant number R01AG031150] to the second author. NR 31 TC 0 Z9 0 U1 2 U2 14 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 1747-0218 EI 1747-0226 J9 Q J EXP PSYCHOL JI Q. J. Exp. Psychol. PD JUN 2 PY 2016 VL 69 IS 6 BP 1210 EP 1226 DI 10.1080/17470218.2015.1079225 PG 17 WC Psychology, Biological; Physiology; Psychology; Psychology, Experimental SC Psychology; Physiology GA DG6GR UT WOS:000372182300014 PM 26252072 ER PT J AU Houston, MN Hoch, MC Hoch, JM AF Houston, Megan N. Hoch, Matthew C. Hoch, Johanna M. TI Health-Related Quality of Life in Athletes: A Systematic Review With Meta-Analysis SO JOURNAL OF ATHLETIC TRAINING LA English DT Review DE patient-centered care; patient outcomes; athletic injuries ID PHYSICAL-ACTIVITY; OUTCOMES RESEARCH; POPULATION; VALIDITY; INJURY; SF-36; CHILDREN; CLINICIAN; BENEFITS; FITNESS AB Context: Assessment of health-related quality of life (HRQOL) after injury is important. Differences in HRQOL between nonathletes and athletes and between injured and uninjured athletes have been demonstrated; however, the evidence has not been synthesized. Objective: To answer the following questions: (1) Does HRQOL differ among adolescent and collegiate athletes and nonathletes? (2) Does HRQOL differ between injured adolescent and collegiate athletes or between athletes with a history of injury and uninjured athletes or those without a history of injury? Data Sources: We systematically searched CINAHL, MEDLINE, SPORTDiscus, and PubMed. A hand search of references was also conducted. Study Selection: Studies were included if they used generic instruments to compare HRQOL outcomes between athletes and nonathletes and between uninjured and injured athletes. Studies were excluded if they did not use a generic instrument, pertained to instrument development, or included retired athletes or athletes with a chronic disease. Data Extraction: We assessed study quality using the modified Downs and Black Index Tool. Bias-corrected Hedges g effect sizes and 95% confidence intervals (CIs) were calculated. The Strength of Recommendation Taxonomy (SORT) was used to determine the overall strength of the recommendation. A random-effects meta-analysis was performed for all studies using the composite or total score. Data Synthesis: Eight studies with modified Downs and Black scores ranging from 70.6% to 88.4% were included. For question 1, the overall random-effects meta-analysis was weak (effect size = 0.27, 95% confidence interval = 0.14, 0.40; P < .001). For question 2, the overall random-effects meta-analysis was moderate (effect size = 0.68, 95% confidence interval = 0.42, 0.95; P < .001). Conclusions: Grade A evidence indicates that athletes reported better HRQOL than nonathletes and that uninjured athletes reported better HRQOL than injured athletes. However, the overall effect for question 1 was weak, suggesting that the differences between athletes and nonathletes may not be clinically meaningful. Clinicians should monitor HRQOL after injury to ensure that all dimensions of health are appropriately treated. C1 [Houston, Megan N.] Keller Army Community Hosp, 900 Washington Rd, West Point, NY 10996 USA. [Hoch, Matthew C.; Hoch, Johanna M.] Old Dominion Univ, Norfolk, VA USA. RP Houston, MN (reprint author), Keller Army Community Hosp, 900 Washington Rd, West Point, NY 10996 USA. EM megan.n.houston.ctr@mail.mil NR 41 TC 0 Z9 0 U1 1 U2 1 PU NATL ATHLETIC TRAINERS ASSOC INC PI DALLAS PA 2952 STEMMONS FREEWAY, DALLAS, TX 75247 USA SN 1062-6050 EI 1938-162X J9 J ATHL TRAINING JI J. Athl. Train. PD JUN PY 2016 VL 51 IS 6 BP 442 EP 453 DI 10.4085/1062-6050-51.7.03 PG 12 WC Sport Sciences SC Sport Sciences GA EI9VI UT WOS:000392857100003 PM 27258942 ER PT J AU Forney, AJ AF Forney, Andrew J. TI Radical Rhetoric, Conservative Goals: The Democratic Society of Kentucky and the Language of Transatlantic Radicalism in the 1790s SO REGISTER OF THE KENTUCKY HISTORICAL SOCIETY LA English DT Article C1 [Forney, Andrew J.] Christian Univ, Armys Capabil Integrat Ctr, Bengaluru, Karnataka, India. [Forney, Andrew J.] US Mil Acad, West Point, NY 10996 USA. RP Forney, AJ (reprint author), Christian Univ, Armys Capabil Integrat Ctr, Bengaluru, Karnataka, India.; Forney, AJ (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 63 TC 0 Z9 0 U1 0 U2 0 PU KENTUCKY HISTORICAL SOC PI FRANKFORT PA 100 W BROADWAY, FRANKFORT, KY 40601 USA SN 0023-0243 EI 2161-0355 J9 REGIST KY HIST SOC JI Regist. Ky. Hist. Soc. PD SUM-FAL PY 2016 VL 114 IS 3-4 BP 431 EP 460 DI 10.1353/khs.2016.0067 PG 30 WC History SC History GA EI0VZ UT WOS:000392194500006 ER PT J AU Estrada, AX Severt, JB Jimenez-Rodriguez, M AF Estrada, Armando X. Severt, Jamie B. Jimenez-Rodriguez, Miliani TI Elaborating on the Conceptual Underpinnings of Resilience SO INDUSTRIAL AND ORGANIZATIONAL PSYCHOLOGY-PERSPECTIVES ON SCIENCE AND PRACTICE LA English DT Editorial Material AB The term resilience has grown in popularity among the general public and within the scientific community. Unfortunately, the rise in popularity has advanced neither our theoretical understanding of this construct nor the methodological approaches to study this topic. Britt, Shen, Sinclair, Grossman, and Klieger (2016) highlighted important conceptual, methodological, and practical advances and shortcomings within the literature on employee resilience. However, critical conceptual issues remain unaddressed within the focal article. Specifically, in our commentary, we differentiate between resiliency and resilience, identify key dimensions of each construct, and explicate the role of adversity and context to further advance our theoretical understanding of this construct. We conclude by discussing the implications of our proposed conceptualization and refinement of resilience for theory, research, and practice. C1 [Estrada, Armando X.] US Army Res Inst Behav & Social Sci, Foundat Sci Res Unit, Aberdeen, MD USA. [Severt, Jamie B.] George Washington Univ, Dept Org Sci & Commun, Washington, DC 20052 USA. [Jimenez-Rodriguez, Miliani] US Army Res Inst Behav & Social Sci, Leader Dev Res Unit, Ft Leavenworth, KS USA. RP Estrada, AX (reprint author), US Army Res Inst Behav & Social Sci, Foundat Sci Res Unit, Aberdeen, MD USA. EM armando.x.estrada@gmail.com NR 12 TC 0 Z9 0 U1 0 U2 0 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 1754-9426 EI 1754-9434 J9 IND ORGAN PSYCHOL-US JI Ind. Organ. Psychol. PD JUN PY 2016 VL 9 IS 2 BP 497 EP 502 DI 10.1017/iop.2016.46 PG 6 WC Psychology, Applied SC Psychology GA DV4FM UT WOS:000382880800042 ER PT J AU Fiske, LC Homeyer, DC Zapor, M Hartzell, J Warkentien, T Weintrob, AC Ganesan, A Burgess, T Snesrud, E Waterman, P Nielsen, L Ressner, RA AF Fiske, Lauren C. Homeyer, Diane C. Zapor, Michael Hartzell, Joshua Warkentien, Tyler Weintrob, Amy C. Ganesan, Anuradha Burgess, Timothy Snesrud, Erik Waterman, Paige Nielsen, Lindsey Ressner, Roseanne A. TI Isolation of Rapidly Growing Nontuberculous Mycobacteria in Wounds Following Combat-Related Injury SO MILITARY MEDICINE LA English DT Article ID INFECTION; ABSCESSUS; SKIN; DISEASE; RESISTANCE; CHELONAE AB Objectives: Rapidly growing nontuberculous mycobacteria (RGNTM) have yet to be described in combatrelated injuries. This study investigates the epidemiology, clinical findings, treatment, and outcomes of RGNTM infections among combat casualties wounded in Afghanistan from 2010 to 2012. Methods: Patients with RGNTM were identified from the Department of Defense Trauma Registry through the Trauma Infectious Disease Outcomes Study. Trauma history, surgical management, and clinical data were collected. Six isolates from patients requiring antimycobacterial therapy were sequenced. Results: Seventeen cases were identified. Six cases, predominantly associated with Mycobacterium abscessus, required aggressive debridement and a median of 180 days of multidrug antimycobacterial therapy that included clofazimine. M. abscessus isolates expressed the erythromycin resistance methylase (erm(41)) gene for inducible macrolide resistance, yet there were no clinical treatment failures when macrolides were utilized in combination therapy. No clonal similarity between M. abscessus isolates was found. Eleven cases had positive wound cultures, but did not require antimycobacterial therapy. The median duration of time of injury to first detection of a RGNTM was 57 days. Conclusions: This represents the first report of RGNTM infections in war-wounded patients. RGNTM should be recognized as potential pathogens in grossly infected combat wounds. Surgical debridement and multidrug antimycobacterial therapy, when clinically indicated, was associated with satisfactory clinical outcomes. C1 [Fiske, Lauren C.; Zapor, Michael; Hartzell, Joshua; Warkentien, Tyler; Weintrob, Amy C.; Ganesan, Anuradha; Burgess, Timothy; Ressner, Roseanne A.] Walter Reed Natl Mil Med Ctr, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. [Homeyer, Diane C.] San Antonio Mil Med Ctr, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. [Hartzell, Joshua; Burgess, Timothy; Waterman, Paige; Nielsen, Lindsey; Ressner, Roseanne A.] Uniformed Serv Univ Hlth Sci, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. [Weintrob, Amy C.; Ganesan, Anuradha] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. [Snesrud, Erik; Waterman, Paige; Nielsen, Lindsey] Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. RP Fiske, LC (reprint author), Walter Reed Natl Mil Med Ctr, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. FU Infectious Disease Clinical Research Program Trauma Infectious Diseases Outcomes Study team FX We thank the Infectious Disease Clinical Research Program Trauma Infectious Diseases Outcomes Study team for their support in this project. NR 21 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JUN PY 2016 VL 181 IS 6 BP 530 EP 536 DI 10.7205/MILMED-D-14-00731 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA DW5LO UT WOS:000383686900011 PM 27244062 ER PT J AU Escolas, HD Ray, LN Escolas, SM AF Escolas, Hollie D. Ray, Lashawnna N. Escolas, Sandra M. TI Personality Traits and Family Styles of Combat Medics in Training SO MILITARY MEDICINE LA English DT Article ID CIRCUMPLEX MODEL; 5-FACTOR MODEL; LIFE-COURSE; SYSTEMS AB This descriptive study examines the relationship between four family types and five personality traits. The four family types are balanced, moderately balanced, midrange, and extreme. The five personality traits are extraversion, openness to experiences, agreeableness, emotional stability, and conscientiousness. Data were collected through anonymous questionnaires distributed to combat-naive Soldiers at the beginning of their advanced individual training. This study utilized the Family Adaptability and Cohesion Evaluation Scale(1) and the Ten-Item Personality Inventory(2) as measures. Overall the analyses found that participants classified as a balanced family type scored significantly higher on the personality traits of extraversion, agreeableness, and openness to experience than those classified in the family types of extreme, midrange, and moderately balanced. It appears that family types are associated with personality traits. This study opens doors to future research including looking at how family and personality types relate to each other in military units and personnel. C1 [Escolas, Hollie D.] Univ Texas San Antonio, Downtown Campus,501 West Cesar E Chavez Blvd, San Antonio, TX 78207 USA. [Escolas, Hollie D.] Oak Ridge Inst Sci & Educ, Maryland Off, 4692 Millennium Dr, Belcamp, MD 21017 USA. [Ray, Lashawnna N.; Escolas, Sandra M.] US Army, Joint Base Lewis McChord, Med Res Directorate West, Tacoma, WA 98433 USA. RP Escolas, HD (reprint author), Univ Texas San Antonio, Downtown Campus,501 West Cesar E Chavez Blvd, San Antonio, TX 78207 USA.; Escolas, HD (reprint author), Oak Ridge Inst Sci & Educ, Maryland Off, 4692 Millennium Dr, Belcamp, MD 21017 USA. FU Department of Defense, Defense Medical Research and Development Program [FY2010]; U.S. Department of Energy; U.S. Army Medical Research and Materiel Command FX We wish to acknowledge the contributions of Rachel Arata-Maiers. Her initial draft provided a great starting point to this article. Funding for this project came from a Department of Defense, Defense Medical Research and Development Program, FY2010 Basic Research Award. This research was supported in part by an appointment to the Student Research participation Program at the U.S. Army Institute of Surgical Research administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy andU.S. Army Medical Research and Materiel Command. NR 22 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JUN PY 2016 VL 181 IS 6 BP 546 EP 552 DI 10.7205/MILMED-D-15-00165 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA DW5LO UT WOS:000383686900013 PM 27244064 ER PT J AU Allen, CJ Straker, RJ Murray, CR Hannay, WM Hanna, MM Meizoso, JP Manning, RJ Schulman, CI Seery, JM Proctor, KG AF Allen, Casey J. Straker, Richard J. Murray, Clark R. Hannay, William M. Hanna, Mena M. Meizoso, Jonathan P. Manning, Ronald J. Schulman, Carl I. Seery, Jason M. Proctor, Kenneth G. TI Recent Advances in Forward Surgical Team Training at the US Army Trauma Training Department SO MILITARY MEDICINE LA English DT Article ID MASS CASUALTY; IMPROVES; CARE AB U.S. Army Forward Surgical Teams (FSTs) are elite, multidisciplinary units that are highly mobile, and rapidly deployable. The mission of the FST is to provide resuscitative and damage control surgery for stabilization of life-threatening injuries in austere environments. The Army Trauma Training Center began in 2001 at the University of Miami Ryder Trauma Center under the direction of COL T.E. Knuth, MC USA (Ret.), as a multimodality combination of lectures, laboratory exercises, and clinical experiences that provided the only predeployment mass casualty and clinical trauma training center for all FSTs. Each of the subsequent five directors has restructured the training based on dynamic feedback from trainees, current military needs, and on the rapid advances in combat casualty care. We have highlighted these evolutionary changes at the Army Trauma Training Center in previous reviews. Under the current director, LTC J.M. Seery, MC USA, there are new team-building exercises, mobile learning modules and simulators, and other alternative methods in the mass casualty exercise. This report summarizes the latest updates to the state of the art training since the last review. C1 [Allen, Casey J.; Straker, Richard J.; Murray, Clark R.; Hannay, William M.; Hanna, Mena M.; Meizoso, Jonathan P.; Manning, Ronald J.; Schulman, Carl I.; Seery, Jason M.; Proctor, Kenneth G.] Univ Miami, Miller Sch Med, Dewitt Daughtry Dept Surg, Ryder Trauma Ctr,Div Trauma, 1800 NW 10th Ave, Miami, FL 33136 USA. [Allen, Casey J.; Straker, Richard J.; Murray, Clark R.; Hannay, William M.; Hanna, Mena M.; Meizoso, Jonathan P.; Manning, Ronald J.; Schulman, Carl I.; Seery, Jason M.; Proctor, Kenneth G.] Univ Miami, Miller Sch Med, Dewitt Daughtry Dept Surg, Ryder Trauma Ctr,Div Surg Crit Care, 1800 NW 10th Ave, Miami, FL 33136 USA. [Schulman, Carl I.; Seery, Jason M.; Proctor, Kenneth G.] Univ Miami, Miller Sch Med, US Army, Trauma Training Dept,Ryder Trauma Ctr, 1800 NW 10th Ave, Miami, FL 33136 USA. RP Allen, CJ (reprint author), Univ Miami, Miller Sch Med, Dewitt Daughtry Dept Surg, Ryder Trauma Ctr,Div Trauma, 1800 NW 10th Ave, Miami, FL 33136 USA.; Allen, CJ (reprint author), Univ Miami, Miller Sch Med, Dewitt Daughtry Dept Surg, Ryder Trauma Ctr,Div Surg Crit Care, 1800 NW 10th Ave, Miami, FL 33136 USA. FU Office of Naval Research [N140610670]; U.S. Army Medical Research and Materiel Command [09078015] FX The successful operation of the FST training at the ATTD described in this article has literally involved hundreds of faculty, staff, students, and volunteers. We thank them for their continued efforts for the betterment of the program. This study was supported by the grants no. N140610670 from the Office of Naval Research and no. 09078015 from U.S. Army Medical Research and Materiel Command. NR 10 TC 0 Z9 0 U1 1 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JUN PY 2016 VL 181 IS 6 BP 553 EP 559 DI 10.7205/MILMED-D-15-00084 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA DW5LO UT WOS:000383686900014 PM 27244065 ER PT J AU Stoddard, DR Robinson, AB Comer, TA Meno, JA Welder, MD AF Stoddard, Douglas R. Robinson, Andrew B. Comer, Tracy A. Meno, Jenifer A. Welder, Matthew D. TI A Surgical Business Composite Score for Army Medicine SO MILITARY MEDICINE LA English DT Article ID INDICATORS AB Measuring surgical business performance for Army military treatment facilities is currently done through 6 business metrics developed by the Army Medical Command (MEDCOM) Surgical Services Service Line (3SL). Development of a composite score for business performance has the potential to simplify and synthesize measurement, improving focus for strategic goal setting and implementation. However, several considerations, ranging from data availability to submetric selection, must be addressed to ensure the score is accurate and representative. This article presents the methodology used in the composite score's creation and presents a metric based on return on investment and a measure of cases recaptured from private networks. C1 [Stoddard, Douglas R.] Madigan Army Med Ctr, 9040 Jackson Ave, Tacoma, WA 98431 USA. [Robinson, Andrew B.; Comer, Tracy A.; Meno, Jenifer A.; Welder, Matthew D.] US Army, Off Surg Gen, Med Command, 7700 Arlington Blvd, Falls Church, VA 22032 USA. RP Stoddard, DR (reprint author), Madigan Army Med Ctr, 9040 Jackson Ave, Tacoma, WA 98431 USA. NR 10 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JUN PY 2016 VL 181 IS 6 BP 567 EP 571 DI 10.7205/MILMED-D-14-00701 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA DW5LO UT WOS:000383686900016 PM 27244067 ER PT J AU Cole, RE Clark, HL Heileson, J DeMay, J Smith, MA AF Cole, Renee E. Clark, Heidi L. Heileson, Jeffery DeMay, Jordan Smith, Martha A. TI Normal Weight Status in Military Service Members Was Associated With Intuitive Eating Characteristic SO MILITARY MEDICINE LA English DT Article ID BODY-MASS INDEX; PSYCHOMETRIC EVALUATION; PHYSICAL-ACTIVITY; UNITED-STATES; OBESITY; BEHAVIORS; HEALTH; MOTIVATION; EXERCISE; ADULTS AB The purpose of this study was to determine the relationship between individual weight status and intuitive eating or motivation for eating characteristics. Participants were predominantly white (57%), Army (91%), enlisted (72%), males (71%), with a mean age of 30 +/- 9 years and mean body mass index (BMI) of 27.0 +/- 4.2 kg/m(2). The cross-sectional, descriptive study included active duty service members (n = 295) recruited from Texas and Washington. Validated Motivation for Eating Scale (MFES) and Intuitive Eating Scale were administered and BMI (m/kg(2)) was dichotomized at <25 or = 25 kg/m(2). Descriptive, correlation, t-test, and logistic regression analysis were conducted for BMI category with demographic, lifestyle, and MFES/Intuitive Eating Scale scores (a = 0.05; 80% power). Thirty-six percent were normal BMI (22.7 +/- 1.6 kg/m(2)) and 64% were overweight/ obese BMI (29.3 +/- 3.3 kg/m(2)). Mean BMI was 27.8 +/- 4.2 kg/m(2) (males) and 24.8 +/- 3.4 kg/m(2) (females) (p < 0.001). Physical MFES type was predominant (77% normal BMI vs. 66% overweight; p = 0.001). Males ate for physical rather than emotional reasons (p = 0.014). Each 1-point increase in Reliance on Internal Hunger Satiety Score was associated with 34% lower odds of being overweight. Disparity existed between sex and intuitive eating characteristic. Increasing awareness of eating influences may improve weight-related dietary behaviors. C1 [Cole, Renee E.] US Army, Environm Med Res Inst, 15 Kansas St, Natick, MA 01760 USA. [Clark, Heidi L.] US Air Force, Joint Base San Antonio Lackland, 59th Med Wing,1701 Kenly Ave, San Antonio, TX 78236 USA. [Heileson, Jeffery] Blanchfield Army Community Hosp, Nutr Care Div, 650 Joel Dr, Ft Campbell, KY 42223 USA. [DeMay, Jordan] Moncrief Army Community Hosp, Nutr Care Div, 4500 Stuart St, Ft Jackson, SC 29207 USA. [Smith, Martha A.] Brian Allgood Army Community Hosp, 19 Hangangno Dong, Yongsan, South Korea. RP Cole, RE (reprint author), US Army, Environm Med Res Inst, 15 Kansas St, Natick, MA 01760 USA. NR 44 TC 0 Z9 0 U1 2 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JUN PY 2016 VL 181 IS 6 BP 589 EP 595 DI 10.7205/MILMED-D-15-00250 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA DW5LO UT WOS:000383686900020 PM 27244071 ER PT J AU Hilber, DJ AF Hilber, David J. TI Binocular Visual Acuity and Corrective Lens Use in the United States Army SO MILITARY MEDICINE LA English DT Article ID REFRACTIVE ERROR; IMPAIRMENT; PREVALENCE; POPULATION; BLINDNESS; EYE AB Purpose: To assess uncorrected and corrected distance and near binocular visual acuity (VA) and the use of corrective lenses in U.S. Army Active Duty, Guard, and Reserve Soldiers. Methods: A descriptive statistical analysis of VA group data from the U.S. Army Vision Readiness Classification Screening system was performed. Data pulls from June 2012 to January 2015 were compared. Results: In January 2015, 62.3% of Soldiers had an uncorrected binocular distance VA of 20/20, 21.2% of Soldiers were worse than 20/40, and 41.4% of Soldiers wore corrective eyewear for distance vision. With correction, 92.5% had a binocular distance VA of 20/20 and 1.4% were worse than 20/40. In January 2015, 32.6% of Soldiers age > 45 had an uncorrected binocular near VA of 20/20, 28.4% of Soldiers age > 45 were worse than 20/40, and 61.9% of Soldiers age > 45 wore corrective eyewear for near vision. With correction, 74.6% had a binocular near VA of 20/20 and 3.0% were worse than 20/40. Data for both years were similar, although there were differences between individual service components. Conclusions: In comparison to the U.S. adult population, U.S. Army Soldiers have better uncorrected and corrected vision and are less likely to wear vision correction. C1 [Hilber, David J.] US Army, Publ Hlth Command, Triserv Vis Conservat & Readiness Program, Oak Ridge Inst Sci & Educ Knowledge Management Co, 5158 Blackhawk Rd, Gunpowder, MD 21010 USA. RP Hilber, DJ (reprint author), US Army, Publ Hlth Command, Triserv Vis Conservat & Readiness Program, Oak Ridge Inst Sci & Educ Knowledge Management Co, 5158 Blackhawk Rd, Gunpowder, MD 21010 USA. NR 8 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JUN PY 2016 VL 181 IS 6 BP 602 EP 608 DI 10.7205/MILMED-D-15-00261 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA DW5LO UT WOS:000383686900022 PM 27244073 ER PT J AU Criman, ET Kurata, WE Matsumoto, KW Aubin, HT Campbell, CE Pierce, LM AF Criman, Erik T. Kurata, Wendy E. Matsumoto, Karen W. Aubin, Harry T. Campbell, Carmen E. Pierce, Lisa M. TI Bone Marrow-Derived Mesenchymal Stem Cells Enhance Bacterial Clearance and Preserve Bioprosthetic Integrity in a Model of Mesh Infection SO PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN LA English DT Article ID VENTRAL HERNIA REPAIR; RANDOMIZED CONTROLLED-TRIAL; ACELLULAR DERMAL MATRICES; TERM-FOLLOW-UP; INCISIONAL HERNIA; POLYPROPYLENE MESH; ESCHERICHIA-COLI; SYNTHETIC MESHES; BIOLOGIC MESHES; COLONIZATION AB Background: The reported incidence of mesh infection in contaminated operative fields is as high as 30% regardless of the material used. Recently, mesenchymal stem cells (MSCs) have been shown to possess favorable immunomodulatory properties and improve tissue incorporation when seeded onto bioprosthetics. The aim of this study was to evaluate whether seeding noncrosslinked bovine pericardium (Veritas Collagen Matrix) with allogeneic bone marrow-derived MSCs improves infection resistance in vivo after inoculation with Escherichia coli (E. coli). Methods: Rat bone marrow-derived MSCs at passage 3 were seeded onto bovine pericardium and cultured for 7 days before implantation. Additional rats (n = 24) were implanted subcutaneously with MSC-seeded or unseeded mesh and inoculated with 7 x 10(5) colony-forming units of E. coli or saline before wound closure (group 1, unseeded mesh/saline; group 2, unseeded mesh/E. coli; group 3, MSC-seeded mesh/E. coli; 8 rats per group). Meshes were explanted at 4 weeks and underwent microbiologic and histologic analyses. Results: MSC-seeded meshes inoculated with E. coli demonstrated superior bacterial clearance and preservation of mesh integrity compared with E. coli-inoculated unseeded meshes (87.5% versus 0% clearance; p = 0.001). Complete mesh degradation concurrent with abscess formation was observed in 100% of rats in the unseeded/E. coli group, which is in contrast to 12.5% of rats in the MSC-seeded/E. coli group. Histologic evaluation determined that remodeling characteristics of E. coli-inoculated MSC-seeded meshes were similar to those of uninfected meshes 4 weeks after implantation. Conclusions: Augmenting a bioprosthetic material with stem cells seems to markedly enhance resistance to bacterial infection in vivo and preserve mesh integrity. C1 [Criman, Erik T.; Aubin, Harry T.] Tripler Army Med Ctr, Dept Gen Surg, Honolulu, HI 96859 USA. [Kurata, Wendy E.; Matsumoto, Karen W.; Campbell, Carmen E.; Pierce, Lisa M.] Tripler Army Med Ctr, Dept Clin Invest, 1 Jarrett White Rd, Honolulu, HI 96859 USA. RP Pierce, LM (reprint author), Tripler Army Med Ctr, Dept Clin Invest, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM lisa.m.pierce.civ@mail.mil NR 41 TC 0 Z9 0 U1 3 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 2169-7574 J9 PRS-GLOB OPEN JI PRS-GLOB. OPEN PD JUN PY 2016 VL 4 IS 6 AR e751 DI 10.1097/GOX.0000000000000765 PG 8 WC Surgery SC Surgery GA EC7ZG UT WOS:000388359100018 PM 27482490 ER PT J AU Ploumis, M Pilalis, LE AF Ploumis, Michail Pilalis, Labros E. TI A New Deal for the Middle East and North Africa SO MEDITERRANEAN QUARTERLY-A JOURNAL OF GLOBAL ISSUES LA English DT Article C1 [Ploumis, Michail] Hellen Army, Harare, Zimbabwe. [Ploumis, Michail] Int Assistance Force Afghanistan, Kabul, Afghanistan. [Ploumis, Michail] US Army, War Coll, Carlisle, PA 17013 USA. [Ploumis, Michail] Univ Peloponnese, Econ, Tripoli, Libya. [Pilalis, Labros E.] Penn Publ Util Commiss, Harrisburg, PA USA. [Pilalis, Labros E.] Indiana Univ, Sch Law Indianapolis, Doctorate Jurisprudence, Bloomington, IN 47405 USA. RP Ploumis, M (reprint author), Hellen Army, Harare, Zimbabwe.; Ploumis, M (reprint author), Int Assistance Force Afghanistan, Kabul, Afghanistan.; Ploumis, M (reprint author), US Army, War Coll, Carlisle, PA 17013 USA.; Ploumis, M (reprint author), Univ Peloponnese, Econ, Tripoli, Libya. NR 30 TC 0 Z9 0 U1 1 U2 1 PU DUKE UNIV PRESS PI DURHAM PA 905 W MAIN ST, STE 18-B, DURHAM, NC 27701 USA SN 1047-4552 EI 1527-1935 J9 MEDITERR Q JI Mediterr. Q. PD JUN PY 2016 VL 27 IS 2 BP 89 EP 100 DI 10.1215/10474552-3618083 PG 12 WC International Relations SC International Relations GA DZ1PU UT WOS:000385611100006 ER PT J AU Rodriguez, LC AF Rodriguez, Ludrena C. TI Maternal-Child Health Simulation Drills SO JOGNN-JOURNAL OF OBSTETRIC GYNECOLOGIC AND NEONATAL NURSING LA English DT Meeting Abstract DE simulation drills; maternal-child health; labor and delivery; postpartum C1 [Rodriguez, Ludrena C.] Tripler Army Med Ctr, Mililani, HI USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0884-2175 EI 1552-6909 J9 JOGNN-J OBST GYN NEO JI JOGNN PD JUN PY 2016 VL 45 IS 3 SU S BP S16 EP S16 PG 1 WC Nursing; Obstetrics & Gynecology SC Nursing; Obstetrics & Gynecology GA DY3NH UT WOS:000385000000032 ER PT J AU Tess, M Kurman, M Kweon, CB AF Tess, Michael Kurman, Matthew Kweon, Chol-Bum TI Spray Characterization and Ignition Delay Measurements of JP-8 and IPK in a Constant-Pressure Flow Chamber SO SAE INTERNATIONAL JOURNAL OF ENGINES LA English DT Article ID FUELS; COMBUSTION; ENGINES AB This research compares the spray development and combustion characteristics of jet propellant 8 (JP-8) and iso-paraffinic kerosene (IPK) through a range of diesel engine in-cylinder operating conditions. Non-reacting spray experiments were performed in a constant-pressure flow chamber with 99% nitrogen gas composition at constant temperature (900 K) and densities ranging from 11-56 kg/m(3). Near-simultaneous, high-speed Mie and schlieren images of the spray were acquired to measure the liquid and vapor penetration lengths of the non-reacting jet. Reacting experiments, consisting of photodiode measurements and intensified high-speed movies of OH* chemiluminescence, were performed at the same thermodynamic conditions as the non-reacting experiments, except with a 21%/79% oxygen/nitrogen ambient gas composition. Measurements of the rate of injection, issued from a single-hole axial common-rail fuel injector, showed negligible differences between the fuels. The non-reacting liquid length of IPK was approximately 20% shorter than JP-8 for the range of tested conditions, which was consistent with the average difference in volatility between the fuels. The ignition delay, determined from the photodiode record, was up to 80% longer for IPK fuel at low density conditions. Additionally, the lift-off length of IPK was measured to be approximately 50% more sensitive to ambient pressure than JP-8. These results provide fundamental information for the calibration and optimization of military diesel engines operating on conventional and alternatively sourced jet fuels. C1 [Tess, Michael; Kurman, Matthew; Kweon, Chol-Bum] US Army, Res Lab, Adelphi, MD 20783 USA. RP Tess, M (reprint author), US Army, Res Lab, Adelphi, MD 20783 USA. EM michael.j.tess@mail.mil NR 37 TC 0 Z9 0 U1 2 U2 2 PU SAE INT PI WARRENDALE PA 400 COMMONWEALTH DR, WARRENDALE, PA 15096 USA SN 1946-3936 EI 1946-3944 J9 SAE INT J ENGINES JI SAE Int. J. Engines PD JUN PY 2016 VL 9 IS 2 BP 899 EP 909 DI 10.4271/2016-01-0736 PG 11 WC Transportation Science & Technology SC Transportation GA DX9JJ UT WOS:000384710600021 ER PT J AU Zabecki, DT AF Zabecki, David T. TI Battlefield Fulda gap SO JOURNAL OF COLD WAR STUDIES LA English DT Book Review C1 [Zabecki, David T.] US Army, Washington, DC 20319 USA. RP Zabecki, DT (reprint author), US Army, Washington, DC 20319 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU MIT PRESS PI CAMBRIDGE PA ONE ROGERS ST, CAMBRIDGE, MA 02142-1209 USA SN 1520-3972 EI 1531-3298 J9 J COLD WAR STUD JI J. Cold War Stud. PD SUM PY 2016 VL 18 IS 3 BP 222 EP 225 DI 10.1162/JCWS_r_00667 PG 4 WC History; International Relations; Political Science SC History; International Relations; Government & Law GA DW9QJ UT WOS:000383996400025 ER PT J AU Mulligan, RP Hanson, JL AF Mulligan, Ryan P. Hanson, Jeffrey L. TI Alongshore momentum transfer to the nearshore zone from energetic ocean waves generated by passing hurricanes SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article ID LONGSHORE CURRENTS; SHEAR INSTABILITIES; TROPICAL CYCLONES; DRAG COEFFICIENT; SURF ZONE; BREAKING; BEACH; STORM; MODEL AB Wave and current measurements from a cross-shore array of nearshore sensors in Duck, NC, are used to elucidate the balance of alongshore momentum under energetic wave conditions with wide surf zones, generated by passing hurricanes that are close to and far from to the coast. The observations indicate that a distant storm (Hurricane Bill, 2009) with large waves has low variability in directional wave characteristics resulting in alongshore currents that are driven mainly by the changes in wave energy. A storm close to the coast (Hurricane Earl, 2010), with strong local wind stress and combined sea and swell components in wave energy spectra, has high variability in wave direction and wave period that influence wave breaking and nearshore circulation as the storm passes. During both large wave events, the horizontal current shear is strong and radiation stress gradients, bottom stress, wind stress, horizontal mixing, and cross-shore advection contribute to alongshore momentum at different spatial locations across the near-shore region. Horizontal mixing during Hurricane Earl, estimated from rotational velocities, was particularly strong suggesting that intense eddies were generated by the high horizontal shear from opposing wind-driven and wave-driven currents. The results provide insight into the cross-shore distribution of the alongshore current and the connection between flows inside and outside the surf zone during major storms, indicating that the current shear and mixing at the interface between the surf zone and shallow inner shelf is strongly dependent on the distance from the storm center to the coast. C1 [Mulligan, Ryan P.] Queens Univ, Dept Civil Engn, Kingston, ON K7L 3N6, Canada. [Hanson, Jeffrey L.] US Army Corps Engn, Field Res Facil, Duck, NC USA. [Hanson, Jeffrey L.] WaveForce Technol LLC, Kill Devil Hills, NC USA. RP Mulligan, RP (reprint author), Queens Univ, Dept Civil Engn, Kingston, ON K7L 3N6, Canada. EM mulligar@queensu.ca FU Natural Science and Engineering Research Council of Canada (NSERC); U.S. Army Corps of Engineers FX This research was supported by a Natural Science and Engineering Research Council of Canada (NSERC) Discovery Grant to the first author, and funding for the instrumentation was provided by the U.S. Army Corps of Engineers. The data used in this work are archived by the U.S. Army Corps of Engineers at the Field Research Facility (FRF) in Duck, NC, and can be accessed at http://www.frf.usace.army.mil/. We thank anonymous reviewers for insightful comments on the original manuscript. Thanks to Kent Hathaway and the FRF staff for maintaining the sensors, cables, and data that provide a solid foundation for nearshore research. NR 40 TC 0 Z9 0 U1 2 U2 2 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-9275 EI 2169-9291 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD JUN PY 2016 VL 121 IS 6 BP 4178 EP 4193 DI 10.1002/2016JC011706 PG 16 WC Oceanography SC Oceanography GA DW2JD UT WOS:000383467800029 ER PT J AU Miller, AS Durham, SW Han, JJ AF Miller, Alex S. Durham, Susan W. Han, Jasmine J. TI Use of Intravenous Thrombolysis to Treat Postoperative Ischemic Stroke After Gynecologic Surgery SO JOURNAL OF GYNECOLOGIC SURGERY LA English DT Article ID PERIOPERATIVE STROKE; INTRAARTERIAL THROMBOLYSIS; SAFETY AB Background: Postoperative acute ischemic stroke may be associated with significant morbidity and mortality. Available treatment options have been limited because of concern about the risk for substantial postoperative bleeding. Data regarding the safety and use of intravenous (I.V.) thrombolysis in postoperative patients has been sparse. Case: A 62-year-old postmenopausal female had an acute ischemic stroke that occurred <1 hour after surgical excision of a vaginal mass. Administration of I.V. alteplase similar to 3.5 hours following the onset of this cerebrovascular accident resulted in complete resolution of symptoms. Bleeding from the surgical site was minimal. Results: To date, this patient has no permanent neurologic deficit secondary to her perioperative acute ischemic stroke. Conclusions: With close surveillance in carefully selected patients, I.V. thrombolysis may be a viable treatment option for acute ischemic stroke following low-risk gynecologic surgical procedures. C1 [Miller, Alex S.; Durham, Susan W.; Han, Jasmine J.] Womack Army Med Ctr, Dept Obstet & Gynecol, Ft Bragg, NC USA. RP Miller, AS (reprint author), 2817 Reilly Rd, Ft Bragg, NC 28310 USA. EM alex.s.miller3.mil@mail.mil NR 10 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1042-4067 EI 1557-7724 J9 J GYNECOL SURG JI J. Gynecol. Surg. PD JUN PY 2016 VL 32 IS 3 BP 201 EP 203 DI 10.1089/gyn.2015.0128 PG 3 WC Obstetrics & Gynecology; Surgery SC Obstetrics & Gynecology; Surgery GA DU4FZ UT WOS:000382169500012 ER PT J AU Wise, JE AF Wise, Joseph E. TI Survival of the Nicest: How Altruism Made Us Human and Why It Pays to Get Along SO PSYCHIATRY-INTERPERSONAL AND BIOLOGICAL PROCESSES LA English DT Book Review C1 [Wise, Joseph E.] US Army, Med Corps, Ft Knox, KY USA. [Wise, Joseph E.] Uniformed Serv Univ Hlth Sci, Walter Reed Natl Mil Med Ctr, Psychiat, Bethesda, MD USA. RP Wise, JE (reprint author), Uniformed Serv Univ Hlth Sci, Walter Reed Natl Mil Med Ctr, Psychiat, Bethesda, MD USA.; Wise, JE (reprint author), Uniformed Serv Univ Hlth Sci, Walter Reed Natl Mil Med Ctr, 8901 Rockville Pike, Bethesda, MD 20889 USA. EM joseph.e.wise.mil@mail.mil NR 8 TC 0 Z9 0 U1 6 U2 6 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0033-2747 EI 1943-281X J9 PSYCHIATRY JI Psychiatry-Interpers. Biol. Process. PD SUM PY 2016 VL 79 IS 2 BP 170 EP 173 DI 10.1080/00332747.2016.1179506 PG 4 WC Psychiatry SC Psychiatry GA DT9UC UT WOS:000381846800006 PM 27724832 ER PT J AU Boyer, NL Forbes, DA Chung, KK AF Boyer, Nathan L. Forbes, Damon A. Chung, Kevin K. TI Practical management of burns and inhalation injury SO CURRENT PULMONOLOGY REPORTS LA English DT Article DE Smoke inhalation injury; Bronchoscopy; Injury severity; Burns ID RESTING ENERGY-EXPENDITURE; COMPUTED TOMOGRAPHIC SCANS; SMOKE-INHALATION; RESUSCITATION; GUIDELINES; SEVERITY; CASUALTIES; DIAGNOSIS; EFFICACY; SEPSIS AB Burn injuries are often associated with profound physiologic derangements due to the nature of the underlying injuries and the overwhelming inflammatory response that ensues. In recent decades, a number of advancements have been made in the management of thermal burns. Inhalation injury frequently occurs in patients with thermal burns and can be a significant source of morbidity and mortality. Due to the intense inflammatory response that occurs after a burn injury, early aggressive volume resuscitation is necessary to minimize the risk of developing multiorgan dysfunction. Adequate sedation and analgesia, early enteral nutrition, physical rehabilitation, excision and grafting, and other supportive measures are also critically important to promoting healing and improving long-term outcomes. This review outlines a general approach to the management of patients with burn and inhalation injuries and highlights some of the recent advances in the care of these patients. C1 [Boyer, Nathan L.; Forbes, Damon A.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. [Chung, Kevin K.] US Army, Inst Surg Res, 3698 Chambers Pass STE B, Ft Sam Houston, TX 78234 USA. [Chung, Kevin K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Boyer, Nathan L.; Forbes, Damon A.] Brooke Army Med Ctr, Pulm & Crit Care Serv, Dept Med, Ft Sam Houston, TX 78234 USA. RP Chung, KK (reprint author), US Army, Inst Surg Res, 3698 Chambers Pass STE B, Ft Sam Houston, TX 78234 USA.; Chung, KK (reprint author), Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. EM nathan.l.boyer.mil@mail.mil; damon.a.forbes.mil@mail.mil; kevin.k.chung.mil@mail.mil NR 36 TC 0 Z9 0 U1 2 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA EI 2199-2428 J9 CURR PULMONOL REP JI Curr. Pulmonol. Rep. PD JUN PY 2016 VL 5 IS 2 BP 63 EP 69 DI 10.1007/s13665-016-0140-1 PG 7 WC Respiratory System SC Respiratory System GA DU9AG UT WOS:000382508000001 ER PT J AU Bell, DG McCann, ET AF Bell, David G. McCann, Edward T. TI Transfusions in trauma SO CURRENT PULMONOLOGY REPORTS LA English DT Article DE Trauma; Transfusion; Resuscitation; Coagulopathy ID BLOOD-CELL TRANSFUSIONS; ACTIVATED FACTOR-VII; HEMOSTATIC RESUSCITATION; FLUID RESUSCITATION; HEMORRHAGIC-SHOCK; IMPROVED SURVIVAL; CONTROLLED-TRIAL; TRANEXAMIC ACID; CLINICAL-TRIALS; DAMAGE CONTROL AB Trauma associated with massive bleeding carries a high mortality even in the setting of early care in a trauma center. Such patients develop a significant coagulopathy soon after injury which contributes to these poor outcomes. Practices such as aggressive resuscitation with crystalloid fluids and red blood cell (RBC) transfusions appear to be associated with worse outcomes when compared to a practice of early blood product resuscitation with a ratio of plasma to platelets to RBCs approaching 1:1:1. Early therapy with tranexamic acid (TXA) appears beneficial as well, perhaps helping to prevent fibrinolysis. Viscoelastic testing offers advantages over conventional coagulation testing in the evaluation of further fibrinolysis and offers some guidance for additional targeted therapy. Many societies and organizations have released updated guidelines and recommendations that reflect these changes. C1 [Bell, David G.; McCann, Edward T.] Brooke Army Med Ctr, Pulm Dis Serv, Dept Med, 3551 Roger Brooke Dr, San Antonio, TX 78234 USA. RP Bell, DG (reprint author), Brooke Army Med Ctr, Pulm Dis Serv, Dept Med, 3551 Roger Brooke Dr, San Antonio, TX 78234 USA. EM david.g.bell.mil@mail.mil; edward.t.mccann2.mil@mail.mil NR 49 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA EI 2199-2428 J9 CURR PULMONOL REP JI Curr. Pulmonol. Rep. PD JUN PY 2016 VL 5 IS 2 BP 94 EP 100 DI 10.1007/s13665-016-0141-0 PG 7 WC Respiratory System SC Respiratory System GA DU9AG UT WOS:000382508000005 ER PT J AU Choi, Y AF Choi, Yong TI Comment on: Concomitant removal of gastric band and sleeve gastrectomy: analysis of outcomes and complications from the ACS-NSQIP database SO SURGERY FOR OBESITY AND RELATED DISEASES LA English DT Editorial Material ID CONVERSION; SURGERY; BYPASS C1 [Choi, Yong] Dwight D Eisenhower Army Med Ctr, Gen Surg Clin, Surg, Ft Gordon, GA 30905 USA. RP Choi, Y (reprint author), Dwight D Eisenhower Army Med Ctr, Gen Surg Clin, Surg, Ft Gordon, GA 30905 USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1550-7289 EI 1878-7533 J9 SURG OBES RELAT DIS JI Surg. Obes. Relat. Dis. PD JUN PY 2016 VL 12 IS 5 BP 989 EP 990 PG 2 WC Surgery SC Surgery GA DT9RM UT WOS:000381840000009 PM 26975803 ER PT J AU Jain, A Kuo, C Jayakumar, P Cameron, J AF Jain, Abhinandan Kuo, Calvin Jayakumar, Paramsothy Cameron, Jonathan TI CONSTRAINT EMBEDDING FOR VEHICLE SUSPENSION DYNAMICS SO ARCHIVE OF MECHANICAL ENGINEERING LA English DT Article AB The goal of this research is to achieve close to real-time dynamics performance for allowing auto-pilot in-the-loop testing of unmanned ground vehicles (UGV) for urban as well as off-road scenarios. The overall vehicle dynamics performance is governed by the multibody dynamics model for the vehicle, the wheel/terrain interaction dynamics and the onboard control system. The topic of this paper is the development of computationally efficient and accurate dynamics model for ground vehicles with complex suspension dynamics. A challenge is that typical vehicle suspensions involve closed-chain loops which require expensive DAE integration techniques. In this paper, we illustrate the use the alternative constraint embedding technique to reduce the cost and improve the accuracy of the dynamics model for the vehicle. C1 [Jain, Abhinandan; Cameron, Jonathan] CALTECH, Jet Prop Lab, 4800 Oak Grove Dr, Pasadena, CA 91016 USA. [Kuo, Calvin] Stanford Univ, Dept Mech Engn, Palo Alto, CA 91016 USA. [Jayakumar, Paramsothy] US Army TARDEC, 6501 E 11 Mile Rd, Warren, MI 48397 USA. RP Jain, A (reprint author), CALTECH, Jet Prop Lab, 4800 Oak Grove Dr, Pasadena, CA 91016 USA. EM jain@jpl.nasa.gov; calvink@stanford.edu; paramsothy.jayakumar.civ@mail.mil; jmc@jpl.nasa.gov NR 11 TC 0 Z9 0 U1 3 U2 3 PU DE GRUYTER OPEN LTD PI WARSAW PA BOGUMILA ZUGA 32A ST, 01-811 WARSAW, POLAND SN 0004-0738 EI 2300-1895 J9 ARCH MECH ENG JI Arch. Mech. Eng. PD JUN PY 2016 VL 63 IS 2 BP 193 EP 213 DI 10.1515/meceng-2016-0011 PG 21 WC Engineering, Mechanical SC Engineering GA DT7AC UT WOS:000381635500002 ER PT J AU Park, J Murphey, YL Masrur, MA AF Park, Jungme Murphey, Yi Lu Masrur, M. Abul TI Intelligent Energy Management and Optimization in a Hybridized All-Terrain Vehicle With Simple On-Off Control of the Internal Combustion Engine SO IEEE TRANSACTIONS ON VEHICULAR TECHNOLOGY LA English DT Article DE Cognitive vehicle energy management; energy optimization; hybrid electric vehicle (HEV); machine learning ID ELECTRIC VEHICLES; POWER MANAGEMENT; STRATEGY; SYSTEM; TRUCK AB This paper presents research in cognitive vehicle energy management for low-cost hybrid electric vehicle ( HEV) power systems for small vehicles, such as all-terrain vehicles ( ATVs). The power system consists of a small engine, a lead-acid battery, and an ultracapacitor. For simplicity of implementation and low hardware cost, engine control is restricted to two states, i. e., ON and OFF, and vehicle speed control is restricted to three discrete levels, namely, high, medium, and low. The authors developed advanced algorithms for modeling and optimizing vehicle energy flow, machine learning of optimal control settings generated by dynamic programmling on real-world drive cycles, and an intelligent energy controller designed for online energy control based on knowledge about the driving mission and knowledge obtained through machine learning. The intelligent vehicle energy controller cognitive intelligent power management ( CIPM) has been implemented and evaluated in a simulated vehicle model and in an ATV, i. e., Polaris Ranger EV, which was converted to an HEV. Experimental results show that the intelligent energy controller CIPM can lead to a significant improvement in fuel economy compared with the existing conventional vehicle controllers in an ATV. C1 [Park, Jungme; Murphey, Yi Lu] Univ Michigan, Dept Elect & Comp Engn, Dearborn, MI 48128 USA. [Masrur, M. Abul] US Army, RDECOM, TARDEC, Warren, MI 49307 USA. RP Park, J (reprint author), Univ Michigan, Dept Elect & Comp Engn, Dearborn, MI 48128 USA. EM jungmepark@gmail.com; yilu@umich.edu; m.a.masrur.civ@mail.mil FU U.S. Army RDECOM-TARDEC FX This work was supported in part by a research grant from the U.S. Army RDECOM-TARDEC. The review of this paper was coordinated by Prof. M. Benbouzid. NR 27 TC 0 Z9 0 U1 8 U2 11 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9545 EI 1939-9359 J9 IEEE T VEH TECHNOL JI IEEE Trans. Veh. Technol. PD JUN PY 2016 VL 65 IS 6 BP 4584 EP 4596 DI 10.1109/TVT.2015.2466655 PG 13 WC Engineering, Electrical & Electronic; Telecommunications; Transportation Science & Technology SC Engineering; Telecommunications; Transportation GA DR7GR UT WOS:000380068500063 ER PT J AU Pasiakos, SM Margolis, LM Murphy, NE McClung, HL Martini, S Gundersen, Y Castellani, JW Karl, JP Teien, HK Madslien, EH Stenberg, PH Young, AJ Montain, SJ McClung, JP AF Pasiakos, Stefan M. Margolis, Lee M. Murphy, Nancy E. McClung, Holy L. Martini, Svein Gundersen, Yngvar Castellani, John W. Karl, James P. Teien, Hilde K. Madslien, Elisabeth H. Stenberg, Pal H. Young, Andrew J. Montain, Scott J. McClung, James P. TI Effects of exercise mode, energy, and macronutrient interventions on inflammation during military training SO PHYSIOLOGICAL REPORTS LA English DT Article DE Endurance exercise; energy deficit; iron status; macronutrients ID PLACEBO-CONTROLLED TRIAL; MUSCLE GLYCOGEN-CONTENT; IRON STATUS; FEMALE SOLDIERS; HEPCIDIN LEVELS; PLASMA INTERLEUKIN-6; PHYSICAL PERFORMANCE; CYTOKINE RESPONSES; SKELETAL-MUSCLE; SERUM HEPCIDIN AB Load carriage (LC) exercise may exacerbate inflammation during training. Nutritional supplementation may mitigate this response by sparing endogenous carbohydrate stores, enhancing glycogen repletion, and attenuating negative energy balance. Two studies were conducted to assess inflammatory responses to acute LC and training, with or without nutritional supplementation. Study 1: 40 adults fed eucaloric diets performed 90-min of either LC (treadmill, mean +/- SD 24 +/- 3 kg LC) or cycle ergometry (CE) matched for intensity (2.2 +/- 0.1 VO2peak L min(-1)) during which combined 10 g protein/46 g carbohydrate (223 kcal) or non-nutritive (22 kcal) control drinks were consumed. Study 2: 73 Soldiers received either combat rations alone or supplemented with 1000 kcal day(-1) from 20 g protein-or 48 g carbohydrate-based bars during a 4-day, 51 km ski march (similar to 45 kg LC, energy expenditure 6155 +/- 515 kcal day(-1) and intake 2866 +/- 616 kcal day(-1)). IL-6, hepcidin, and ferritin were measured at baseline, 3-h post exercise (PE), 24-h PE, 48-h PE, and 72-h PE in study 1, and before (PRE) and after (POST) the 4-d ski march in study 2. Study 1: IL-6 was higher 3-h and 24-h post exercise (PE) for CE only (mode x time, P < 0.05), hepcidin increased 3-h PE and recovered by 48-h, and ferritin peaked 24-h and remained elevated 72-h PE (P < 0.05), regardless of mode and diet. Study 2: IL-6, hepcidin and ferritin were higher (P < 0.05) after training, regardless of group assignment. Energy expenditure (r = 0.40), intake (r = -0.26), and balance (r = -0.43) were associated (P < 0.05) with hepcidin after training. Inflammation after acute LC and CE was similar and not affected by supplemental nutrition during energy balance. The magnitude of hepcidin response was inversely related to energy balance suggesting that eating enough to balance energy expenditure might attenuate the inflammatory response to military training. C1 [Pasiakos, Stefan M.; Margolis, Lee M.; Murphy, Nancy E.; McClung, Holy L.; Karl, James P.; Young, Andrew J.; Montain, Scott J.; McClung, James P.] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA USA. [Martini, Svein; Gundersen, Yngvar; Teien, Hilde K.; Madslien, Elisabeth H.] Norwegian Def Res Estab, Kjeller, Norway. [Castellani, John W.] US Army Res Inst Environm Med, Thermal Mt & Med Div, Natick, MA USA. [Stenberg, Pal H.] Norwegian Navy, Gen Def Mat Catering & Combat Feeding Sect, Rodskiferveien, Norway. RP Pasiakos, SM (reprint author), USARIEM, Mil Nutr Div, 15 Kansas St,Bldg 42, Natick, MA 01760 USA. EM stefan.m.pasiakos.civ@mail.mil RI Pasiakos, Stefan/E-6295-2014; OI Pasiakos, Stefan/0000-0002-5378-5820; , Lee/0000-0002-0652-1304 NR 34 TC 1 Z9 1 U1 2 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2051-817X J9 PHYSIOL REP JI PHYSIOL. REP. PD JUN PY 2016 VL 4 IS 11 AR e12820 DI 10.14814/phy2.12820 PG 11 WC Physiology SC Physiology GA DS0AG UT WOS:000380256900015 ER PT J AU Molle, A Fabbri, F Campi, D Lamperti, A Rotunno, E Cinquanta, E Lazzarini, L Kaplan, D Swaminathan, V Bernasconi, M Longo, M Salviati, G AF Molle, Alessandro Fabbri, Filippo Campi, Davide Lamperti, Alessio Rotunno, Enzo Cinquanta, Eugenio Lazzarini, Laura Kaplan, Daniel Swaminathan, Venkataraman Bernasconi, Marco Longo, Massimo Salviati, Giancarlo TI Evidence of Native Cs Impurities and Metal-Insulator Transition in MoS2 Natural Crystals SO ADVANCED ELECTRONIC MATERIALS LA English DT Article ID MOLYBDENUM-DISULFIDE; MONOLAYER MOS2; 2-DIMENSIONAL MATERIALS; INTERCALATION COMPOUNDS; VALLEY POLARIZATION; ELECTRONICS; TRANSISTORS; OPTOELECTRONICS; TRANSPORT; CONTACTS AB In the realm of layered materials beyond graphene, MoS2 gains a primary role due to its semiconducting nature and n-type transport down to the 2D limit that makes it extremely appealing for electronic and optoelectronic applications. The intrinsic presence of defects causes MoS2 to undergo localization effects. In the present work, solid evidence of Cs impurities in bulky MoS2 crystals in a concentration well beyond the sensitivity threshold of independent compositional spectrometry probes is brought. Unlike conventional intercalation of alkali metals in MoS2, on the basis of the measured crystal structure and ab initio calculations, it is proposed that the incorporation of Cs is stabilized by complex where one Cs atom is associated with a double S vacancy therein resulting in an overall n-type doping of the MoS2. The field effect transistor based on this kind of Cs-doped MoS2 multilayer flakes exhibits a variable range hopping transport and a metal-insulator transition. C1 [Molle, Alessandro; Lamperti, Alessio; Cinquanta, Eugenio; Longo, Massimo] CNR IMM, Lab MDM, Via C Olivetti 2, I-20864 Agrate Brianza, Italy. [Fabbri, Filippo; Rotunno, Enzo; Lazzarini, Laura; Salviati, Giancarlo] IMEM CNR, Parco Area Sci 37a, I-43124 Parma, Italy. [Campi, Davide; Bernasconi, Marco] Univ Milano Bicocca, Dipartimento Sci Mat, Via R Cozzi 55, I-20125 Milan, Italy. [Kaplan, Daniel; Swaminathan, Venkataraman] US Army RDECOM ARDEC, Fuze Precis Armaments & Technol Directorate, Picatinny Arsenal, NJ 07806 USA. RP Molle, A (reprint author), CNR IMM, Lab MDM, Via C Olivetti 2, I-20864 Agrate Brianza, Italy.; Salviati, G (reprint author), IMEM CNR, Parco Area Sci 37a, I-43124 Parma, Italy.; Bernasconi, M (reprint author), Univ Milano Bicocca, Dipartimento Sci Mat, Via R Cozzi 55, I-20125 Milan, Italy. EM alessandro.molle@mdm.imm.cnr.it; marco.bernasconi@unimib.it; giancarlo.salviati@cnr.it RI lazzarini, laura/B-7009-2015; Longo, Massimo/G-8893-2013; OI lazzarini, laura/0000-0001-5346-4026; Longo, Massimo/0000-0002-6364-8184; Cinquanta, Eugenio Luigi/0000-0002-4721-5215; Molle, Alessandro/0000-0002-3860-4120 FU U.S. Army [W911NF-14-1-0612] FX The authors acknowledge D. Rotta for the fabrication of the MoS2 devices. A.M., F.F, E.R., E.C., L.L., M.L., and G.S. acknowledge funding from U.S. Army Award/Contract W911NF-14-1-0612. NR 50 TC 1 Z9 1 U1 11 U2 17 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2199-160X J9 ADV ELECTRON MATER JI Adv. Electron. Mater. PD JUN PY 2016 VL 2 IS 6 AR 1600091 DI 10.1002/aelm.201600091 PG 9 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Science & Technology - Other Topics; Materials Science; Physics GA DR4ZI UT WOS:000379912100013 ER PT J AU Cavender, AP Ball, DB AF Cavender, Anthony P. Ball, Donald B. TI Home Cures for Ailing Horses: A Case Study of Nineteenth-Century Vernacular Veterinary Medicine in Tennessee SO AGRICULTURAL HISTORY LA English DT Article ID HISTORY AB Vernacular human medicine, otherwise known as folk or popular medicine, has received considerable attention from scholars in the United States, but little research has been done on how lay people dealt with livestock ailments prior to the professionalization of veterinary medicine. Using Tennessee in the nineteenth century as a case study, this paper examines the corpus of popular knowledge on the identification and treatment of horse ailments available to lay people in printed sources, focusing primarily on newspapers and to a lesser extent on patent medicine brochures and horse care handbooks. Information on horse medicine found in the newspapers was often in the form of a letter to the editor or as an excerpt from another periodical. Collectively, newspapers served as a national clearing house for popular veterinary knowledge. An examination of the horse remedies reported in the newspapers and other printed materials shows a close correspondence between the materia medica and therapeutic modalities used for treating humans with those used for treating horses. The paper also considers folk remedies for horse ailments and folk healers known as "horse doctors," but the discussion is limited due to paucity of information available in the historical record. C1 [Cavender, Anthony P.] East Tennessee State Univ, Anthropol, Johnson City, TN 37614 USA. [Ball, Donald B.] US Army, Corps Engineers, Washington, DC 20310 USA. RP Cavender, AP (reprint author), East Tennessee State Univ, Anthropol, Johnson City, TN 37614 USA. NR 150 TC 0 Z9 0 U1 2 U2 2 PU AGRICULTURAL HISTORY SOCIETY PI LITTLE ROCK PA UALR, DEPT HISTORY, 2801 S UNIVERSITY AVE, LITTLE ROCK, AR 72324-1099 USA SN 0002-1482 EI 1533-8290 J9 AGR HIST JI Agric. Hist. PD SUM PY 2016 VL 90 IS 3 BP 311 EP 337 DI 10.3098/ah.2016.090.3.311 PG 27 WC Agriculture, Multidisciplinary; History; History & Philosophy Of Science SC Agriculture; History; History & Philosophy of Science GA DR4PP UT WOS:000379885000002 ER PT J AU Roberts, D Gebhardt, DL Gaskill, SE Roy, TC Sharp, MA AF Roberts, Delia Gebhardt, Deborah L. Gaskill, Steven E. Roy, Tanja C. Sharp, Marilyn A. TI Current considerations related to physiological differences between the sexes and physical employment standards SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM LA English DT Article; Proceedings Paper CT 2nd International Conference on Physical Employment Standards (PES) CY AUG 23-26, 2015 CL Canmore, CANADA SP Univ Alberta, Fac Phys Educ & Recreat, Univ Alberta, Work Physiol Lab, Univ Alberta Conf Fund, Justice Inst British Columbia, No Alberta Inst Technol, Strathcona County Emergency Serv, UNIFOR, Appl Physiol, Nutr, & Metab, Canadian Sci Publisher, Univ, Occupat Testing Ctr, Canadian Soc Exercise Physiol, Edmonton Fire Rescue Serv, Edmonton Police Serv, Royal Canadian Mounted Police, K Div, Univ Alberta Int, Univ Alberta, Golden Bears Hockey, Univ Alberta, Golden Bears Volleyball, Univ Alberta, Pandas Hockey, Univ Alberta, Golden Bears Football, Univ Alberta, Canadian Athlet Coaching Ctr, Human Kinet Canada DE physical employment standards; selection standards; sex differences; job-task performance; work performance; occupational injury; physical screening; physical selection ID CORRECTIONAL OFFICER APPLICANTS; CRUCIATE LIGAMENT INJURY; ACUTE MOUNTAIN-SICKNESS; FEMALE ARMY TRAINEES; RISK-FACTORS; UNITED-STATES; US ARMY; FITNESS TEST; THERMOREGULATORY RESPONSES; MUSCULOSKELETAL INJURIES AB The use of physical employment standards (PES) has helped ensure that workers have the physical attributes necessary to complete their jobs in a safe and efficient manner. However, PES used in the selection processes have not always reflected the critical physical requirements of the job tasks. Women generally have smaller anthropometric stature than men, less muscle mass, and therefore less strength, power, and endurance, particularly in the upper body. Nonetheless, these attributes in themselves are not valid grounds for exclusion from employment in physically demanding occupations. Selection standards based upon size or strength, irrespective of the job requirements, have resulted in the barring of capable women from physically demanding jobs, claims of gender bias, and costly litigations. To ensure all individuals are provided with equal access to employment, accurate characterization of the critical physical requirements of the job is paramount. This paper summarizes the existing research related to disparities between the sexes that contribute to sex differences in job performance in physically demanding occupations including physical and legal factors. Strategies for mitigating these differences in the setting of PES and the meeting of minimum employment standards are discussed. Where available, injury rates for women and men in physically demanding occupations are presented and the etiology considered. Finally, areas for further research are identified. C1 [Roberts, Delia] Selkirk Coll, Sch Univ Arts & Sci, Amer Coll Sports Med FACSM, 2808 9th Ave, Castlegar, BC VIN 2Z1, Canada. [Gebhardt, Deborah L.] Human Performance Syst Inc, 5000 Sunnyside Ave,Suite 203, Beltsville, MD 20705 USA. [Gaskill, Steven E.] Univ Montana, Hlth & Human Performance Dept Exercise Sci, Missoula, MT 59812 USA. [Roy, Tanja C.] US Army Publ Hlth Command, Epidemiol & Dis Surveillance, Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. [Sharp, Marilyn A.] US Army, Mil Performance Div, Environm Med Res Inst, 42 Gen Green Ave, Natick, MA 01760 USA. RP Roberts, D (reprint author), Selkirk Coll, Sch Univ Arts & Sci, Amer Coll Sports Med FACSM, 2808 9th Ave, Castlegar, BC VIN 2Z1, Canada. EM droberts@selkirk.ca NR 99 TC 2 Z9 2 U1 4 U2 6 PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS PI OTTAWA PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA SN 1715-5312 EI 1715-5320 J9 APPL PHYSIOL NUTR ME JI Appl. Physiol. Nutr. Metab. PD JUN PY 2016 VL 41 IS 6 SU 2 BP S108 EP S120 DI 10.1139/apnm-2015-0540 PG 13 WC Nutrition & Dietetics; Physiology; Sport Sciences SC Nutrition & Dietetics; Physiology; Sport Sciences GA DQ8AE UT WOS:000379430500007 PM 27277561 ER PT J AU Nguyen, LH Tran, TD AF Nguyen, Lam H. Tran, Trac D. TI Efficient and Robust RFI Extraction Via Sparse Recovery SO IEEE JOURNAL OF SELECTED TOPICS IN APPLIED EARTH OBSERVATIONS AND REMOTE SENSING LA English DT Article; Proceedings Paper CT IEEE International Geoscience and Remote Sensing Symposium (IGARSS) CY JUL 26-31, 2015 CL Milan, ITALY SP IEEE DE Compressed sensing (CS); interference; noise-source separation; radar; radio-frequency interference (RFI); sparse recovery; sparsity; synthetic aperture radar (SAR); ultra-wideband (UWB) ID SYNTHETIC-APERTURE RADAR; WIDE-BAND RADAR; INTERFERENCE SUPPRESSION; SIGNAL RECONSTRUCTION; MATCHING PURSUIT; SUBSPACE PURSUIT; SAR; ALGORITHM; PROJECTIONS; SYSTEMS AB This paper presents a simple adaptive framework for robust separation and extraction of multiple sources of radio-frequency interference (RFI) from raw ultra-wideband (UWB) radar signals in challenging bandwidth management environments. RFI sources pose critical challenges for UWB systems since 1) RFI often occupies a wide range of the radar's operating frequency spectrum; 2)RFI might have significant power; and 3) RFI signals are difficult to predict and model due to the nonstationary nature as well as the complexity of various communication devices. Our proposed framework involves an initial RFI estimation step that operates directly on already contaminated radar signals to identify RFI-dominant frequency sub-bands. This vital prior information is then taken into account to construct an adaptive RFI dictionary with various sinusoidal patterns covering the aforementioned RFI-contaminated frequency spectrum. Finally, we employ a sparsity-driven optimization strategy to separate and then extract RFI from the received radar signals. Our method can be implemented as a denoising preprocessing stage for raw radar signals prior to image formation and other follow-up tasks such as target detection and classification. Recovery results from extensive simulated data sets as well as real-world signals collected by the U.S. Army Research Laboratory (ARL) UWB synthetic aperture radar (SAR) systems illustrate the robustness and effectiveness of our proposed framework. C1 [Nguyen, Lam H.] US Army Res Lab, RF Signal Proc & Modeling Branch, Adelphi, MD 20783 USA. [Tran, Trac D.] Johns Hopkins Univ, Dept Elect & Comp Engn, Baltimore, MD 21218 USA. RP Nguyen, LH (reprint author), US Army Res Lab, RF Signal Proc & Modeling Branch, Adelphi, MD 20783 USA. EM lam.h.nguyen2.civ@mail.mil; trac@jhu.edu NR 54 TC 0 Z9 0 U1 6 U2 6 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1939-1404 EI 2151-1535 J9 IEEE J-STARS JI IEEE J. Sel. Top. Appl. Earth Observ. Remote Sens. PD JUN PY 2016 VL 9 IS 6 SI SI BP 2104 EP 2117 DI 10.1109/JSTARS.2016.2528884 PG 14 WC Engineering, Electrical & Electronic; Geography, Physical; Remote Sensing; Imaging Science & Photographic Technology SC Engineering; Physical Geography; Remote Sensing; Imaging Science & Photographic Technology GA DR5HW UT WOS:000379935100002 ER PT J AU Gurram, P Kwon, H Davidson, C AF Gurram, Prudhvi Kwon, Heesung Davidson, Charles TI Coalition Game Theory-Based Feature Subspace Selection for Hyperspectral Classification SO IEEE JOURNAL OF SELECTED TOPICS IN APPLIED EARTH OBSERVATIONS AND REMOTE SENSING LA English DT Article; Proceedings Paper CT IEEE International Geoscience and Remote Sensing Symposium (IGARSS) CY JUL 26-31, 2015 CL Milan, ITALY SP IEEE DE Coalition game theory (CGT); feature selection; hyperspectral classification; Shapely value (SV); sparse kernel learning AB In this paper, an algorithm to randomly select feature subspaces for hyperspectral image classification using the principle of coalition game theory (CGT) is presented. The feature selection algorithms associated with nonlinear kernel-based support vector machines (SVM) are either NP-hard or greedy and hence, not very optimal. To deal with this problem, a metric based on the principles of CGT called Shapely value (SV) and a sampling approximation is used to determine the contributions of individual features toward the classification task. Feature subsets are randomly drawn from a probability distribution function (pdf) generated using normalized SVs of the individual features. These feature subsets are then used to build kernels corresponding to individual weak classifiers in the sparse kernel-based ensemble learning (SKEL) framework. By weighting the kernels optimally and sparsely, a small number of useful subsets of features are selected which improve the generalization performance of the ensemble classifier. The algorithm is applied on real hyperspectral datasets, and the results are presented in the paper. C1 [Gurram, Prudhvi; Kwon, Heesung] US Army Res Lab, Adelphi, MD 20783 USA. [Davidson, Charles] Sci & Technology Corp, Edgewood, MD 21040 USA. RP Gurram, P (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM pkgurram@ieee.org; heesung.kwon.civ@mail.mil; charles.e.davidson40.ctr@mail.mil NR 19 TC 0 Z9 0 U1 6 U2 6 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1939-1404 EI 2151-1535 J9 IEEE J-STARS JI IEEE J. Sel. Top. Appl. Earth Observ. Remote Sens. PD JUN PY 2016 VL 9 IS 6 SI SI BP 2354 EP 2364 DI 10.1109/JSTARS.2016.2531984 PG 11 WC Engineering, Electrical & Electronic; Geography, Physical; Remote Sensing; Imaging Science & Photographic Technology SC Engineering; Physical Geography; Remote Sensing; Imaging Science & Photographic Technology GA DR5HW UT WOS:000379935100022 ER PT J AU Sahane, D Santare, MH Powers, BM Gazonas, GA AF Sahane, Dattatraya Santare, Michael H. Powers, Brian M. Gazonas, George A. TI Computational simulations of wave propagation in microcrack-damaged media under prestress SO INTERNATIONAL JOURNAL OF FRACTURE LA English DT Article DE Micro cracks; Damage; Waves; Numerical simulation; Prestress ID ANISOTROPIC EFFECTIVE MODULI; BALLISTIC PERFORMANCE; CERAMIC TARGETS; IMPACT; TILES; MODEL AB Direct computational simulations of unidirectional wave propagation through uniaxially prestressed, microcrack-damaged media are conducted to study the interaction between the prestress and stress wave parameters. Tensile and compressive waves, tensile and compressive prestresses and various orientational distributions of microcrack damage are analyzed. The relationships among the input wave amplitude, wavelength and prestress magnitude and the output wave speed and wave attenuation are studied. The results show that wave speed and attenuation depend on the prestress and the wavelength in a complex way. In the cases of compressive waves traveling through tensile prestress and tensile waves passing through compressive prestress, the wave response depends on the ratio of the amplitude of the applied stress pulse to the magnitude of the prestress (defined as R). Specifically, the simulations show that the compressive wave speed through tensile prestressed media increases gradually with an increase in R, while the tensile wave speed in media under compressive prestress, decreases with increase in R, but the change is abrupt at a particular R value. In the cases of sufficiently small R, the wave speeds match the results of Su et al. (Eng Fract Mech 74: 1436-1455, 2007) where the cracks are always open or always closed. However, above a certain wavelength (a cut-off wavelength), the wave speed is no longer a function of wavelength and, furthermore, this cut-off wavelength varies with R. C1 [Sahane, Dattatraya; Santare, Michael H.] Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA. [Sahane, Dattatraya; Santare, Michael H.] Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. [Powers, Brian M.; Gazonas, George A.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen, MD 21005 USA. RP Santare, MH (reprint author), Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA.; Santare, MH (reprint author), Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. EM santare@udel.edu FU United States Army Research Laboratory through the Composite Materials Technology; Center for Composite Materials at the University of Delaware FX This research was supported by the United States Army Research Laboratory through the Composite Materials Technology cooperative in agreement with the Center for Composite Materials at the University of Delaware. NR 25 TC 0 Z9 0 U1 2 U2 2 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0376-9429 EI 1573-2673 J9 INT J FRACTURE JI Int. J. Fract. PD JUN PY 2016 VL 199 IS 2 BP 185 EP 198 DI 10.1007/s10704-016-0103-0 PG 14 WC Materials Science, Multidisciplinary; Mechanics SC Materials Science; Mechanics GA DR6HF UT WOS:000380002300004 ER PT J AU Skimmyhorn, WL AF Skimmyhorn, William L. TI Comparing Military and Civilian Household Finances: Descriptive Evidence from Recent Surveys SO JOURNAL OF CONSUMER AFFAIRS LA English DT Article ID EDUCATION; LITERACY AB Despite significant media and policy attention to the financial conditions of military and civilian households in American over the past few years, little is known about their relative standing and decision making. Using data from large national surveys, this analysis provides descriptive evidence on key differences for comparable young, low-moderate income and education military and civilian respondents. I find that military members have more types of savings accounts, more problematic credit card behaviors, and equivalent use of alternative financial services. I briefly discuss directions for future research and some policy implications. C1 [Skimmyhorn, William L.] US Mil Acad, Dept Social Sci, Off Econ & Manpower Anal, West Point, NY 10996 USA. RP Skimmyhorn, WL (reprint author), US Mil Acad, Dept Social Sci, Off Econ & Manpower Anal, West Point, NY 10996 USA. EM william.skimmyhorn@usma.edu FU FINRA Investor Education Foundation FX This paper was prepared with financial support from the FINRA Investor Education Foundation. The opinions provided herein are those of the author and do not necessarily reflect the views of the Financial Industry Regulatory Authority, the FINRA Investor Education Foundation, the U.S. Military Academy, the Department of the Army, or the Department of Defense. NR 15 TC 0 Z9 0 U1 2 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0022-0078 EI 1745-6606 J9 J CONSUM AFF JI J. Consum. Aff. PD SUM PY 2016 VL 50 IS 2 BP 471 EP 483 DI 10.1111/joca.12109 PG 13 WC Business; Economics SC Business & Economics GA DR7AV UT WOS:000380053300009 ER PT J AU Acon-Chen, C Koenig, JA Smith, GR Truitt, AR Thomas, TP Shih, TM AF Acon-Chen, Cindy Koenig, Jeffrey A. Smith, Garrett R. Truitt, Amber R. Thomas, Thaddeus P. Shih, Tsung-Ming TI Evaluation of acetylcholine, seizure activity and neuropathology following high-dose nerve agent exposure and delayed neuroprotective treatment drugs in freely moving rats SO TOXICOLOGY MECHANISMS AND METHODS LA English DT Article DE Acetylcholine; adenosine receptor agonist; anticholinergics; anticonvulsant; benzodiazepines; glutamate receptor antagonist; microdialysis; midazolam; N6-Cyclopentyladenosine; nerve agent; neuropathology; neuroprotectant; neurosteroids; scopolamine; soman ID SOMAN-INDUCED SEIZURES; EXTRACELLULAR STRIATAL ACETYLCHOLINE; KAINATE RECEPTOR ANTAGONIST; GUINEA-PIGS; ADENOSINE RECEPTORS; STATUS EPILEPTICUS; GABA(A) RECEPTORS; IN-VIVO; ANTICONVULSANT TREATMENT; BENZODIAZEPINE-RECEPTOR AB Organophosphorus nerve agents such as soman (GD) inhibit acetylcholinesterase, producing an excess of acetylcholine (ACh), which results in respiratory distress, convulsions and status epilepticus that leads to neuropathology. Several drugs (topiramate, clobazam, pregnanolone, allopregnanolone, UBP 302, cyclopentyladenosine [CPA], ketamine, midazolam and scopolamine) have been identified as potential neuroprotectants that may terminate seizures and reduce brain damage. To systematically evaluate their efficacy, this study employed in vivo striatal microdialysis and liquid chromatography to respectively collect and analyze extracellular ACh in freely moving rats treated with these drugs 20min after seizure onset induced by a high dose of GD. Along with microdialysis, EEG activity was recorded and neuropathology assessed at 24h. GD induced a marked increase of ACh, which peaked at 30min post-exposure to 800% of control levels and then steadily decreased toward baseline levels. Approximately 40min after treatment, only midazolam (10mg/kg) and CPA (60mg/kg) caused a significant reduction of ACh levels, with CPA reducing ACh levels more rapidly than midazolam. Both drugs facilitated a return to baseline levels at least 55min after treatment. At 24h, only animals treated with CPA (67%), midazolam (18%) and scopolamine (27%) exhibited seizure termination. While all treatments except for topiramate reduced neuropathology, CPA, midazolam and scopolamine showed the greatest reduction in pathology. Our results suggest that delayed treatment with CPA, midazolam, or scopolamine is effective at reducing GD-induced seizure activity and neuropathology, with CPA and midazolam capable of facilitating a reduction in GD-induced ACh elevation. C1 [Acon-Chen, Cindy; Koenig, Jeffrey A.; Smith, Garrett R.; Truitt, Amber R.; Thomas, Thaddeus P.; Shih, Tsung-Ming] US Army Med Res Inst Chem Def, Pharmacol Branch, Div Res, Aberdeen Proving Ground, MD 21010 USA. RP Shih, TM (reprint author), US Army Med Res Inst Chem Def, 2900 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM tsungming.a.shih.civ@mail.mil FU NIH/NIAID (IAA) [AOD14018-001-00000]; USAMRICD [A120-B.P2014-02]; U.S. Department of Energy FX This research was supported by an Interagency Agreement (IAA) between NIH/NIAID (IAA #AOD14018-001-00000) and the USAMRICD (#A120-B.P2014-02) for Chemicals Affecting the Nervous System - Anticonvulsants/Neuroprotectants. This research was supported in part by an appointment (Cindy Acon-Chen, Jeffrey A. Koenig, Garrett R. Smith, and Amber R. Truitt) to the Postgraduate Research Participation Program at the U.S. Army Medical Research Institute of Chemical Defense administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USAMRMC. NR 75 TC 0 Z9 0 U1 2 U2 4 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND SN 1537-6516 EI 1537-6524 J9 TOXICOL MECH METHOD JI Toxicol. Mech. Methods PD JUN PY 2016 VL 26 IS 5 BP 378 EP 388 DI 10.1080/15376516.2016.1197992 PG 11 WC Toxicology SC Toxicology GA DR7AT UT WOS:000380053100010 PM 27329284 ER PT J AU Dougherty, CM Xue, L Pulskamp, J Bedair, S Polcawich, R Morgan, B Bashirullah, R AF Dougherty, Christopher M. Xue, Lin Pulskamp, Jeffrey Bedair, Sarah Polcawich, Ronald Morgan, Brian Bashirullah, Rizwan TI A 10 V Fully-Integrated Switched-Mode Step-up Piezo Drive Stage in 0.13 mu m CMOS Using Nested-Bootstrapped Switch Cells SO IEEE JOURNAL OF SOLID-STATE CIRCUITS LA English DT Article DE Arbitrary waveforms; bidirectional; boot-strapped switch; charge-pump; dc-dc conversion; driver; fully integrated; piezo; switched-capacitor; voltage-compliant ID CONVERTER AB A completely integrated 3.3 V to 10 Vpk-pk bidirectional switched-capacitor ladder converter is presented for driving the piezo actuators of a 2 mm wing micro-robotic flying insect. The 0.1-10 MHz converter, fabricated in 1.2 V/3.3 V triple-well 0.13 mu m CMOS, operates as a switched-mode amplifier with 0-3.3 V waveforms at the input and a constant 3x step-up while exhibiting symmetric drive strength for positive and negative load currents. A feedforward switching scheme that effectively bootstraps gate-drive signals for the power switches of the ladder converter has been implemented to enable output waveforms above both the supply and device voltage rating, between 0 V and similar to 10 V. Non-overlapping clock signals float with the dc-500 Hz arbitrary input waveform, or a 2x scaled replica, while keeping all transistors within safe operating conditions. A voltage compliant sub-circuit, the Nested-Bootstrapped Switch (NBS) cell, is introduced as a building block for the creation of the gate-drive signals. On-chip MIM capacitors and 3.3 V I/O MOS switches for the ladder converter were sized based on a charge-multiplier representation of the converter and the output impedance concept. Experiments show actuation of a 2 mm wing prototype, an effective 5 nF peak load, and efficiency of 77% at 800 mu W and 80% at 32 mu W. C1 [Dougherty, Christopher M.] Texas Instruments Inc, D-85356 Freising Weihenstephan, Germany. [Dougherty, Christopher M.; Xue, Lin; Bashirullah, Rizwan] Univ Florida, Dept Elect & Comp Engn, Gainesville, FL 32611 USA. [Xue, Lin] Qualcomm Technol Inc, San Diego, CA 92121 USA. [Pulskamp, Jeffrey; Bedair, Sarah; Polcawich, Ronald; Morgan, Brian] US Army Res Lab, Adelphi, MD 20783 USA. RP Dougherty, CM (reprint author), Texas Instruments Inc, D-85356 Freising Weihenstephan, Germany. EM chrisdoc@ufl.edu FU U.S. Army Research Laboratory [W911NF-08-2-0035] FX This work was supported by the U.S. Army Research Laboratory under Agreement W911NF-08-2-0035. NR 20 TC 0 Z9 0 U1 4 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9200 EI 1558-173X J9 IEEE J SOLID-ST CIRC JI IEEE J. Solid-State Circuit PD JUN PY 2016 VL 51 IS 6 BP 1475 EP 1486 DI 10.1109/JSSC.2016.2551221 PG 12 WC Engineering, Electrical & Electronic SC Engineering GA DR2QD UT WOS:000379748100012 ER PT J AU Perliger, A Koehler-Derrick, G Pedahzur, A AF Perliger, Arie Koehler-Derrick, Gabriel Pedahzur, Ami TI The Gap Between Participation and Violence: Why We Need to Disaggregate Terrorist 'Profiles' SO INTERNATIONAL STUDIES QUARTERLY LA English DT Article ID POLITICAL VIOLENCE; SUICIDE TERRORISM; NETWORK ANALYSIS; RECRUITMENT; POVERTY; RADICALIZATION; EXPLORATION; CENTRALITY; EDUCATION; MEMBERS AB For decades, practitioners and academics sought to identify a common terrorist "profile." However, the consensus in both the policy realm and academia suggests that, so far, these efforts produced only modest insights. This research note identifies and addresses a major impediment to previous studies of terrorist profiles: conceptualization. We argue that ambiguities in the definition of the term terrorist lead to an inconsistent and aggregated operationalization in the existing literature. Previous studies attempt to identify the factors correlated with a willingness to commit violence rather than the factors that correlate with the willingness to join an organization that commits violence. We test our claim by disaggregating the roles and responsibilities of members of various Islamist terrorist networks. We provide initial evidence that disaggregation presents a promising first step toward identifying specific profiles for different types of terrorists. C1 [Perliger, Arie] US Mil Acad, Combating Terrorism Ctr, Terrorism Studies, West Point, NY 10996 USA. [Perliger, Arie] US Mil Acad, Dept Social Sci, West Point, NY 10996 USA. [Koehler-Derrick, Gabriel] Harvard Univ, Dept Govt, Cambridge, MA 02138 USA. [Pedahzur, Ami] Univ Texas Austin, Govt, Austin, TX 78712 USA. [Pedahzur, Ami] Univ Texas Austin, Israel & Diaspora Studies, Austin, TX 78712 USA. RP Perliger, A (reprint author), US Mil Acad, Combating Terrorism Ctr, Terrorism Studies, West Point, NY 10996 USA.; Perliger, A (reprint author), US Mil Acad, Dept Social Sci, West Point, NY 10996 USA. EM aperliger@gmail.com NR 80 TC 1 Z9 1 U1 14 U2 16 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0020-8833 EI 1468-2478 J9 INT STUD QUART JI Int. Stud. Q. PD JUN PY 2016 VL 60 IS 2 BP 220 EP 229 DI 10.1093/isq/sqv010 PG 10 WC International Relations; Political Science SC International Relations; Government & Law GA DR2UE UT WOS:000379758600003 ER PT J AU Le Gonidec, E Maquart, M Duron, S Savini, H Cazajous, G Vidal, PO Chenilleau, MC Roseau, JB Benois, A Dehan, C Kugelman, J Leparc-Goffart, I Vedy, S AF Le Gonidec, Erwan Maquart, Marianne Duron, Sandrine Savini, Helene Cazajous, Geraldine Vidal, Pierre-Olivier Chenilleau, Marie-Caroline Roseau, Jean-Baptiste Benois, Alain Dehan, Celine Kugelman, Jeffrey Leparc-Goffart, Isabelle Vedy, Serge TI Clinical Survey of Dengue Virus Circulation in the Republic of Djibouti between 2011 and 2014 Identifies Serotype 3 Epidemic and Recommends Clinical Diagnosis Guidelines for Resource Limited Settings SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID SURVEILLANCE; INFECTION; AFRICA AB Dengue virus is endemic globally, throughout tropical and sub-tropical regions. While the number of epidemics due to the four DENV serotypes is pronounced in East Africa, the total number of cases reported in Africa (16 million infections) remained at low levels compared to Asia (70 million infections). The French Armed forces Health Service provides epidemiological surveillance support in the Republic of Djibouti through the Bouffard Military hospital. Between 2011 and 2014, clinical and biological data of suspected dengue syndromes were collected at the Bouffard Military hospital and analyzed to improve Dengue clinical diagnosis and evaluate its circulation in East Africa. Examining samples from patients that presented one or more Dengue-like symptoms the study evidenced 128 Dengue cases among 354 suspected cases (36.2% of the non-malarial Dengue-like syndromes). It also demonstrated the circulation of serotypes 1 and 2 and reports the first epidemic of serotype 3 infections in Djibouti which was found in all of the hospitalized patients in this study. Based on these results we have determined that screening for Malaria and the presence of the arthralgia, gastro-intestinal symptoms and lymphopenia <1,000cell/mm(3) allows for negative predictive value and specificity of diagnosis in isolated areas superior to 80% up to day 6. This study also provides evidence for an epidemic of Dengue virus serotype 3 previously not detected in Djibouti. C1 [Le Gonidec, Erwan; Vidal, Pierre-Olivier] Bouffard Mil Hosp, Emergency Dept, Djibouti, Djibouti. [Maquart, Marianne; Kugelman, Jeffrey; Leparc-Goffart, Isabelle] Armed Forces Biomed Res Inst, French Natl Reference Ctr Arbovirus, Marseille, France. [Duron, Sandrine] GSBdD Marseille Aubagne, French Armed Forces Ctr Epidemiol & Publ Hlth CES, Marseille, France. [Savini, Helene] Laveran Mil Teaching Hosp, Dept Infect & Trop Dis, Marseille, France. [Cazajous, Geraldine; Chenilleau, Marie-Caroline; Roseau, Jean-Baptiste] Bouffard Mil Hosp, Dept Med, Djibouti, Djibouti. [Benois, Alain] Bouffard Mil Hosp, Dept Anesthesiol & Intens Care, Djibouti, Djibouti. [Dehan, Celine; Vedy, Serge] Bouffard Mil Hosp, Dept Biol, Djibouti, Djibouti. [Kugelman, Jeffrey] US Army Med Res & Mat Command, Ft Detrick, MD USA. RP Maquart, M (reprint author), Armed Forces Biomed Res Inst, French Natl Reference Ctr Arbovirus, Marseille, France. EM mmaquart.irba@gmail.com NR 27 TC 0 Z9 0 U1 3 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD JUN PY 2016 VL 10 IS 6 AR e0004755 DI 10.1371/journal.pntd.0004755 PG 10 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA DQ6WL UT WOS:000379346200023 PM 27322644 ER PT J AU McNesby, KL Homan, BE Benjamin, RA Boyle, VM Densmore, JM Biss, MM AF McNesby, Kevin L. Homan, Barrie E. Benjamin, Richard A. Boyle, Vincent M. Densmore, John M. Biss, Matthew M. TI Invited Article: Quantitative imaging of explosions with high-speed cameras SO REVIEW OF SCIENTIFIC INSTRUMENTS LA English DT Article ID PYROMETRY; TEMPERATURE; COMBUSTION; PRESSURE; FLAMES; SOOT; AIR; DIAGNOSTICS; FIREBALLS; EMISSION AB The techniques presented in this paper allow for mapping of temperature, pressure, chemical species, and energy deposition during and following detonations of explosives, using high speed cameras as the main diagnostic tool. This work provides measurement in the explosive near to far-field (0-500 charge diameters) of surface temperatures, peak air-shock pressures, some chemical species signatures, shock energy deposition, and air shock formation. C1 [McNesby, Kevin L.; Homan, Barrie E.; Benjamin, Richard A.] Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Boyle, Vincent M.] TKC Global, Aberdeen Proving Ground, MD 21005 USA. [Densmore, John M.] Lawrence Livermore Natl Lab, Livermore, CA 94550 USA. [Biss, Matthew M.] Los Alamos Natl Lab, Los Alamos, NM 87545 USA. RP McNesby, KL (reprint author), Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. NR 79 TC 1 Z9 1 U1 6 U2 11 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0034-6748 EI 1089-7623 J9 REV SCI INSTRUM JI Rev. Sci. Instrum. PD JUN PY 2016 VL 87 IS 5 AR 051301 DI 10.1063/1.4949520 PG 14 WC Instruments & Instrumentation; Physics, Applied SC Instruments & Instrumentation; Physics GA DQ4QE UT WOS:000379187600001 PM 27250366 ER PT J AU Keller, CB Rafuse, ES AF Keller, Christian B. Rafuse, Ethan S. TI The Civil War Battlefield Staff Ride in the Twenty-first Century SO CIVIL WAR HISTORY LA English DT Article C1 [Keller, Christian B.] US Army, War Coll, Dept Natl Secur & Strategy, Hist, Carlisle, PA 17013 USA. [Rafuse, Ethan S.] US Army, Command & Gen Staff Coll, Hist, Ft Leavenworth, KS USA. RP Keller, CB (reprint author), US Army, War Coll, Dept Natl Secur & Strategy, Hist, Carlisle, PA 17013 USA. NR 37 TC 0 Z9 0 U1 0 U2 0 PU KENT STATE UNIV PRESS PI KENT PA C/O JOURNALS DEPT, KENT, OH 44242 USA SN 0009-8078 EI 1533-6271 J9 CIVIL WAR HIST JI Civil War Hist. PD JUN PY 2016 VL 62 IS 2 BP 201 EP 213 PG 13 WC History SC History GA DQ1SI UT WOS:000378980300006 ER PT J AU Ananworanich, J Abrams, EJ AF Ananworanich, Jintanat Abrams, Elaine J. TI Time to prioritise the UNAIDS 90-90-90 targets for infants SO LANCET HIV LA English DT Editorial Material ID CHILD HIV TRANSMISSION; ANTIRETROVIRAL THERAPY; INFECTED INFANTS; DIAGNOSIS; MORTALITY; ELIMINATION; CHALLENGES C1 [Ananworanich, Jintanat] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. [Ananworanich, Jintanat] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD 20817 USA. [Abrams, Elaine J.] Columbia Univ, Int Ctr AIDS Care & Treatment Programs, Mailman Sch Publ Hlth, New York, NY USA. [Abrams, Elaine J.] Columbia Univ, Coll Phys & Surg, New York, NY USA. RP Ananworanich, J (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA.; Ananworanich, J (reprint author), Henry M Jackson Fdn Adv Mil Med, Bethesda, MD 20817 USA. EM jananworanich@hivresearch.org NR 13 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER INC PI SAN DIEGO PA 525 B STREET, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 2352-3018 J9 LANCET HIV JI Lancet HIV PD JUN PY 2016 VL 3 IS 6 BP E241 EP E243 DI 10.1016/S2352-3018(16)30013-3 PG 4 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA DQ1GS UT WOS:000378950100003 PM 27240784 ER PT J AU Snyder, BA Munter, AD Houston, MN Hoch, JM Hoch, MC AF Snyder, Brice A. Munter, Alexander D. Houston, Megan N. Hoch, Johanna M. Hoch, Matthew C. TI INTERRATER AND INTRARATER RELIABILITY OF THE SEMMES-WEINSTEIN MONOFILAMENT 4-2-1 STEPPING ALGORITHM SO MUSCLE & NERVE LA English DT Article DE feet; light touch; Semmes Weinstein monofilament; sensation; somatosensory ID CHRONIC ANKLE INSTABILITY; SENSATION TESTS; INJURIES; INDIVIDUALS; SENSITIVITY; SPORTS; OSTEOARTHRITIS; EPIDEMIOLOGY; SENSIBILITY; THRESHOLD AB Introduction: Semmes-Weinstein Monofilaments (SWM) are used to examine light touch sensation of the skin. Reliability of the 4-2-1 stepping algorithm approach for determining light touch detection thresholds has not been examined. The purpose of this study was to determine the interrater and intrarater reliability of the SWM 4-2-1 stepping algorithm on the plantar surface of the foot. Methods: Four raters with varying levels of SWM assessment experience tested light touch sensation over the plantar aspect of the first metatarsal head in 14 healthy adults. During the initial session, all raters performed the 4-2-1 stepping algorithm technique on each subject to determine interrater reliability. One week later, subjects were reassessed by 2 raters to determine intrarater reliability. Results: Interrater reliability ranged from moderate-to-good (ICC2,1 = 0.62-0.92). Intrarater reliability also ranged from moderate-to-good (ICC2,1 = 0.61-0.85). Conclusions The 4-2-1 stepping algorithm demonstrated acceptable interrater and intrarater reliability when measured in healthy adults. C1 [Snyder, Brice A.; Munter, Alexander D.; Hoch, Johanna M.; Hoch, Matthew C.] Old Dominion Univ, Sch Phys Therapy & Athlet Training, Norfolk, VA 23529 USA. [Houston, Megan N.] Keller Army Community Hosp, West Point, NY USA. RP Hoch, MC (reprint author), Old Dominion Univ, Sch Phys Therapy & Athlet Training, Norfolk, VA 23529 USA. EM mhoch@odu.edu NR 33 TC 4 Z9 4 U1 1 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0148-639X EI 1097-4598 J9 MUSCLE NERVE JI Muscle Nerve PD JUN PY 2016 VL 53 IS 6 BP 918 EP 924 DI 10.1002/mus.24944 PG 7 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA DQ2HK UT WOS:000379023200014 PM 26474392 ER PT J AU Just, MG Hohmann, MG Hoffmann, WA AF Just, Michael G. Hohmann, Matthew G. Hoffmann, William A. TI Where fire stops: vegetation structure and microclimate influence fire spread along an ecotonal gradient SO PLANT ECOLOGY LA English DT Article DE Feedback; Fire ecology; Longleaf pine; Savanna; Streamhead pocosin; Wetland ID LONGLEAF PINE ECOSYSTEM; SAVANNA-FOREST TRANSITION; ECOLOGICAL THRESHOLDS; POSITIVE FEEDBACKS; MODELS; RISK; FUEL; RESTORATION; TEMPERATURE; CONVERSION AB Positive feedbacks influenced by direct and indirect interactions between fire, vegetation, and microclimate can allow pyrophilic and pyrophobic ecosystems to co-occur in the same landscape, resulting in the juxtaposition of flammable and non-flammable vegetation. To quantify the drivers of these feedbacks, we combined measurements of vegetation, fuels, and microclimate with observations of fire spread along ecotonal gradients. We established 113 permanent transects (consisting of 532 plots), each traversing an ecotone between savanna and wetland in the Sandhills of North Carolina, USA. In each plot, we recorded cover of ten plant functional types. We collected surface fuels at a subset of our transects. We continuously monitored microclimate (nine meteorological variables) across 21 representative ecotones. Following prescribed fire, we measured fire spread along each transect. Vegetation structure and microclimate significantly predicted fire spread along the savanna-wetland ecotone. Fire spread was most influenced by vegetation structure, specifically C-4 grass cover, which accounted for 67 % of the variance explained by our model. We have identified the components of the fire, vegetation, and microclimate feedback that control where fires stop under current conditions, but their control should not be considered absolute. For example, when ignited in savanna, prescribed burns continued through wetland vegetation 43 % of the time. The feedback operating within these systems may be relatively weak as compared to other savanna systems. Environmental changes may alter fire spread extent, and with it ecosystem boundaries, or even ecosystem states. C1 [Just, Michael G.; Hoffmann, William A.] N Carolina State Univ, Dept Plant & Microbial Biol, Raleigh, NC 27695 USA. [Hohmann, Matthew G.] US Army, Corps Engineers, Engineer Res & Dev Ctr, POB 9005, Champaign, IL 61826 USA. RP Just, MG (reprint author), N Carolina State Univ, Dept Plant & Microbial Biol, Raleigh, NC 27695 USA. EM mjust@ncsu.edu OI Just, Michael/0000-0003-2493-9269 FU US Army Engineer Research and Development Center [W9132T-11-2-0007]; North Carolina State University [W9132T-11-2-0007]; Southeast Climate Science Center fellowship FX We thank A. Ballard, S. Bell, B. Breslow, K. Fraboni, S. Goyette, R. Sanders, M. Walz, and A. Whitehead for research assistance. We also thank the Fort Bragg Endangered Species and Forestry branches for logistic support. This research was supported by a cooperative agreement between the US Army Engineer Research and Development Center and North Carolina State University (W9132T-11-2-0007 to W.A.H.). M.G.J. received support from a Southeast Climate Science Center fellowship. NR 72 TC 4 Z9 4 U1 22 U2 29 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1385-0237 EI 1573-5052 J9 PLANT ECOL JI Plant Ecol. PD JUN PY 2016 VL 217 IS 6 BP 631 EP 644 DI 10.1007/s11258-015-0545-x PG 14 WC Plant Sciences; Ecology; Forestry SC Plant Sciences; Environmental Sciences & Ecology; Forestry GA DQ4IH UT WOS:000379166900004 ER PT J AU Pasco, TE Kaller, MD Harlan, R Kelso, WE Rutherford, DA Roberts, S AF Pasco, T. E. Kaller, M. D. Harlan, R. Kelso, W. E. Rutherford, D. A. Roberts, S. TI Predicting Floodplain Hypoxia in the Atchafalaya River, Louisiana, USA, a Large, Regulated Southern Floodplain River System SO RIVER RESEARCH AND APPLICATIONS LA English DT Article DE hypoxia; Atchafalaya River; flood pulse; general additive model; floodplain ID AQUATIC HABITAT CHARACTERISTICS; MURRAY-DARLING BASIN; FISH ASSEMBLAGES; WATER-QUALITY; TEMPERATE FLOODPLAIN; NUTRIENT LIMITATION; COMMUNITY STRUCTURE; APALACHICOLA RIVER; BLACKWATER EVENT; FLOW REGULATION AB The Atchafalaya River Basin Floodway (ARBF), a regulated river/floodplain distributary of the Mississippi River, experiences an annual flood pulse that strongly influences floodplain physicochemistry. We developed several metrics to investigate the relationship between the timing and magnitude of the flood pulse and floodplain hypoxia, which in most years is a spatially extensive and temporally prolonged problem in the lower ARBF. Principal components analysis of flood metrics from 2001 to 2009 revealed contrasting flood types (early cool and late warm), but component-based general linear models were unable to predict the magnitude of hypoxia in ARBF water management areas (WMAs). Further analyses based on temperature and geographic information system-determined WMA inundation with generalized additive models (GAMs) revealed WMA-specific patterns of hypoxia, but the likelihood of hypoxia consistently increased when temperatures approached 20 degrees C and inundation rose above 20-30%. Validation with held-out data based on logistic regression indicated that the models constructed with the 2001-2009 temperature and inundation data were able to accurately predict the probabilities of hypoxia in two WMAs based on data collected from 2010 to 2013. The GAMs were an effective tool for visualizing and predicting the probability of hypoxia based on two easily generated parameters. Our analyses indicate that modification of the Atchafalaya River flood pulse could reduce the magnitude of hypoxia within the lower ARBF, subject to engineering (control structure operation) and economic (commercial fisheries production) constraints, by minimizing floodplain inundation after water temperatures reach 20 degrees C. Copyright (c) 2015 John Wiley & Sons, Ltd. C1 [Pasco, T. E.; Kaller, M. D.; Harlan, R.; Kelso, W. E.; Rutherford, D. A.] Louisiana State Univ, Ctr Agr, Sch Renewable Nat Resources, Baton Rouge, LA 70803 USA. [Roberts, S.] US Army Corps Engineers, New Orleans Dist, New Orleans, LA USA. RP Pasco, TE (reprint author), Louisiana State Univ, Ctr Agr, Sch Renewable Nat Resources, Baton Rouge, LA 70803 USA. EM tpasco1@lsu.edu FU U.S. Army Corps of Engineers FX The authors thank the U.S. Army Corps of Engineers for funding and Matt Engel, Brian Heimann, Daniel Hill, Kayla Kimmel, Michael Krumrine, Jerry Lang, Paula Tate, Tory Mason, Alex Perrett, Adam Piehler, Aaron Podey, Rachel Walley, and Angela Williamson with their help in data collection. Any use of trade, firm, or product names is for descriptive purposes only and does not imply endorsement by the US Government. This manuscript was approved for publication by the Director of the Louisiana Agricultural Experiment Station as manuscript 2014-241-18859. NR 68 TC 1 Z9 1 U1 2 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1535-1459 EI 1535-1467 J9 RIVER RES APPL JI River Res. Appl. PD JUN PY 2016 VL 32 IS 5 BP 845 EP 855 DI 10.1002/rra.2903 PG 11 WC Environmental Sciences; Water Resources SC Environmental Sciences & Ecology; Water Resources GA DP7YQ UT WOS:000378715500003 ER PT J AU Tiffan, KF Hatten, JR Trachtenbarg, DA AF Tiffan, K. F. Hatten, J. R. Trachtenbarg, D. A. TI Y Assessing Juvenile Salmon Rearing Habitat and Associated Predation Risk in a Lower Snake River Reservoir SO RIVER RESEARCH AND APPLICATIONS LA English DT Article DE habitat; fall Chinook salmon; smallmouth bass; Snake River; modelling; predation; riprap; Lower Granite Reservoir ID FALL CHINOOK SALMON; SMALLMOUTH BASS; COLUMBIA RIVER; FISH COMMUNITIES; MOVEMENT; CONSTRUCTION; IMPOUNDMENTS; HATCHERY; SYSTEM; REACH AB Subyearling fall Chinook salmon (Oncorhynchustshawytscha) in the Columbia River basin exhibit a transient rearing strategy and depend on connected shoreline habitats during freshwater rearing. Impoundment has greatly reduced the amount of shallow-water rearing habitat that is exacerbated by the steep topography of reservoirs. Periodic dredging creates opportunities to strategically place spoils to increase the amount of shallow-water habitat for subyearlings while at the same time reducing the amount of unsuitable area that is often preferred by predators. We assessed the amount and spatial arrangement of subyearling rearing habitat in Lower Granite Reservoir on the Snake River to guide future habitat improvement efforts. A spatially explicit habitat assessment was conducted using physical habitat data, two-dimensional hydrodynamic modelling and a statistical habitat model in a geographic information system framework. We used field collections of subyearlings and a common predator [smallmouth bass (Micropterusdolomieu)] to draw inferences about predation risk within specific habitat types. Most of the high-probability rearing habitat was located in the upper half of the reservoir where gently sloping landforms created low lateral bed slopes and shallow-water habitats. Only 29% of shorelines were predicted to be suitable (probability >0.5) for subyearlings, and the occurrence of these shorelines decreased in a downstream direction. The remaining, less suitable areas were composed of low-probability habitats in unmodified (25%) and riprapped shorelines (46%). As expected, most subyearlings were found in high-probability habitat, while most smallmouth bass were found in low-probability locations. However, some subyearlings were found in low-probability habitats, such as riprap, where predation risk could be high. Given their transient rearing strategy and dependence on shoreline habitats, subyearlings could benefit from habitat creation efforts in the lower reservoir where high-probability habitat is generally lacking. Published 2015. This article is a U.S. Government work and is in the public domain in the USA. C1 [Tiffan, K. F.; Hatten, J. R.] US Geol Survey, Western Fisheries Res Ctr, 5501A Cook Underwood Rd, Cook, WA 98605 USA. [Trachtenbarg, D. A.] US Army, Corps Engineers, Walla Walla, WA USA. RP Tiffan, KF (reprint author), US Geol Survey, Western Fisheries Res Ctr, 5501A Cook Underwood Rd, Cook, WA 98605 USA. EM ktiffan@usgs.gov OI Tiffan, Kenneth/0000-0002-5831-2846 FU US Army Corps of Engineers [W68SBV02850847] FX We thank our US Geological Survey colleagues, in particular, Tom Batt, Matt Sholtis, Scott St. John, Brad Bickford, Tobyn Rhodes and John Erhardt, whose efforts contributed to this study. The constructive comments of anonymous reviewers improved this manuscript. This study was funded by the US Army Corps of Engineers under contract W68SBV02850847. Any use of trade, firm or product names is for descriptive purposes only and does not imply endorsement by the US government. NR 41 TC 2 Z9 2 U1 3 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1535-1459 EI 1535-1467 J9 RIVER RES APPL JI River Res. Appl. PD JUN PY 2016 VL 32 IS 5 BP 1030 EP 1038 DI 10.1002/rra.2934 PG 9 WC Environmental Sciences; Water Resources SC Environmental Sciences & Ecology; Water Resources GA DP7YQ UT WOS:000378715500020 ER PT J AU Rotunno, E Fabbri, F Cinquanta, E Kaplan, D Longo, M Lazzarini, L Molle, A Swaminathan, V Salviati, G AF Rotunno, E. Fabbri, F. Cinquanta, E. Kaplan, D. Longo, M. Lazzarini, L. Molle, A. Swaminathan, V. Salviati, G. TI Structural, optical and compositional stability of MoS2 multi-layer flakes under high dose electron beam irradiation SO 2D MATERIALS LA English DT Article DE molybdenum disulfide; cathodoluminescence; electron irradiation; transmission electron microscopy; material encapsulation ID LIGHT-EMITTING-DIODES; RADIATION-DAMAGE; MONOLAYER MOS2; GRAPHENE; PHOTOLUMINESCENCE; MICROSCOPY AB MoS2 multi-layer flakes, exfoliated from geological molybdenite, have been exposed to high dose electron irradiation showing clear evidence of crystal lattice and stoichiometry modifications. A massive surface sulfur depletion is induced together with the consequent formation of molybdenum nanoislands. It is found that a nanometric amorphous carbon layer, unwillingly deposited during the transmission electron microscope experiments, prevents the formation of the nanoislands. In the absence of the carbon layer, the formation of molybdenum grains proceeds both on the top and bottom surfaces of the flake. If carbon is present on both the surfaces then the formation ofMograins is completely prevented. C1 [Rotunno, E.; Fabbri, F.; Lazzarini, L.; Salviati, G.] IMEM CNR Inst, Parco Area Sci 37-A, I-43124 Parma, Italy. [Cinquanta, E.; Longo, M.; Molle, A.] IMM CNR, Lab MDM, Agrate Brianza, Italy. [Kaplan, D.; Swaminathan, V.] US Army RDECOM ARDEC, Fuze Precis Armaments & Technol Directorate, Picatinny Arsenal, NJ USA. RP Fabbri, F (reprint author), IMEM CNR Inst, Parco Area Sci 37-A, I-43124 Parma, Italy. EM filippo.fabbri@imem.cnr.it RI lazzarini, laura/B-7009-2015; Longo, Massimo/G-8893-2013 OI lazzarini, laura/0000-0001-5346-4026; Longo, Massimo/0000-0002-6364-8184 FU US Army [W911NF-14-1-0612] FX The authors want to thank the economical support of US Army by means of the contract W911NF-14-1-0612. NR 28 TC 2 Z9 2 U1 17 U2 23 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 2053-1583 J9 2D MATER JI 2D Mater. PD JUN PY 2016 VL 3 IS 2 AR 025024 DI 10.1088/2053-1583/3/2/025024 PG 7 WC Materials Science, Multidisciplinary SC Materials Science GA DP5XL UT WOS:000378571400044 ER PT J AU Wang, GX Slough, WJ Pandey, R Karna, SP AF Wang, Gaoxue Slough, William J. Pandey, Ravindra Karna, Shashi P. TI Degradation of phosphorene in air: understanding at atomic level SO 2D MATERIALS LA English DT Article DE phosphorene; degradation; density functional theory; first principles molecular dynamics ID EXFOLIATED BLACK PHOSPHORUS; MOLECULAR-DYNAMICS; PHOTOOXIDATION; ELECTRONICS; TRANSISTORS; DEFECTS; DENSITY; METALS; SET AB Phosphorene is a promising two-dimensional (2D) material with a direct band gap, high carrier mobility, and anisotropic electronic properties. Phosphorene-based electronic devices, however, are found to degrade upon exposure to air. In this paper, we provide an atomic level understanding of the stability of phosphorene in terms of its interaction with O-2 and H2O. The results based on density functional theory together with first principles molecular dynamics calculations show that O-2 could the spontaneously dissociate on phosphorene at room temperature. H2O will not strongly interact with pristine phosphorene, however, an exothermic reaction could occur if phosphorene is first oxidized. The pathway of oxidation first, followed by exothermic reaction with water is the most likely route for the chemical degradation of phosphorene-based devices in air. C1 [Wang, Gaoxue; Slough, William J.; Pandey, Ravindra] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. [Karna, Shashi P.] US Army Res Lab, Weap & Mat Res Directorate, ATTN RDRL WM, Aberdeen Proving Ground, MD 21005 USA. RP Pandey, R (reprint author), Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. EM pandey@mtu.edu RI Wang, Gaoxue/C-9492-2017 OI Wang, Gaoxue/0000-0003-2539-3405 FU ARL [W911NF-14-2-0088] FX Helpful discussions with Dr V Swaminathan and S Gowtham are acknowledged. Financial support from ARL W911NF-14-2-0088 is obtained. RAMA and Superior, high performance computing clusters at Michigan Technological University, were used in obtaining results presented in this paper. NR 34 TC 6 Z9 6 U1 32 U2 61 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 2053-1583 J9 2D MATER JI 2D Mater. PD JUN PY 2016 VL 3 IS 2 AR 025011 DI 10.1088/2053-1583/3/2/025011 PG 7 WC Materials Science, Multidisciplinary SC Materials Science GA DP5XL UT WOS:000378571400031 ER PT J AU Hausner, MB Wilson, KP Gaines, DB Suarez, F Scoppettone, GG Tyler, SW AF Hausner, Mark B. Wilson, Kevin P. Gaines, D. Bailey Suarez, Francisco Scoppettone, G. Gary Tyler, Scott W. TI Projecting the effects of climate change and water management on Devils Hole pupfish (Cyprinodon diabolis) survival SO ECOHYDROLOGY LA English DT Article DE Devils Hole; climate change; conservation; computational fluid dynamics; water management ID AQUATIC ECOSYSTEM; NEVADENSIS; HABITAT; NEVADA; CARBON AB Aquatic ecosystems of North American deserts are frequently very restricted in area and tend to harbour very specialized species endemic to their restricted habitats. Small changes in environmental conditions of these specialized forms may jeopardize their persistence. A notable example of endemic and specialized species that may have been influenced by slight changes in its habitat is the Devils Hole pupfish (Cyprinodon diabolis), which occurs only in a small pool ecosystem in the Mojave Desert of the Southwestern United States. In this study, we use a computational fluid dynamic (CFD) model to examine the physical effects of climate change and local groundwater management on Devils Hole and combine those results with a conceptual ecological model to consider the impacts of those changes on annual recruitment of C.diabolis. The CFD model predicts water temperatures as a response to climate and water level, and the ecological model is used to determine the timing of tipping points that may encourage or suppress the annual recruitment of C.diabolis. The combination of interdisciplinary modelling approaches offers a method to quantify and compare the suitability of habitat under a range of management and climate scenarios. Our results show that the influence of water level on peak temperatures in Devils Hole (and on the ecosystem's suitability for C.diabolis) is an order of magnitude greater than the influence of climate change. Copyright (c) 2015 John Wiley & Sons, Ltd. C1 [Hausner, Mark B.; Tyler, Scott W.] Univ Nevada, Dept Geol Sci & Engn, MS 172, Reno, NV 89557 USA. [Hausner, Mark B.; Suarez, Francisco] Pontificia Univ Catolica Chile, Dept Ingn Hidraul & Ambiental, Ave Vicuna Mackenna 4860, Santiago, Chile. [Hausner, Mark B.] Desert Res Inst, Div Hydrol Sci, 755 East Flamingo Rd, Las Vegas, NV 89119 USA. [Wilson, Kevin P.; Gaines, D. Bailey] Death Valley Natl Pk, Pahrump Field Off, 1321 So Hwy 160,Suite 1, Pahrump, NV 89048 USA. [Gaines, D. Bailey] US Army Corps Engineers, Whitney Lake Off, 285 CR 3602, Clifton, TX 76634 USA. [Scoppettone, G. Gary] US Geol Survey, Western Fisheries Res Ctr, Reno, NV USA. RP Hausner, MB (reprint author), Div Hydrol Sci, 755 East Flamingo Rd, Las Vegas, NV 89119 USA. EM mark.hausner@dri.edu FU Sulo and Aileen Maki Endowment FX The authors thank Sachiko Sueki and an anonymous reviewer for their thoughtful and constructive comments on the manuscript. This research was made possible by the Death Valley Natural History Association, the Nevada Department of Wildlife, US National Park Service grant J8R07090002, NSF-EAR-0929638, NSF-EAR-1128999, the Pontificia Universidad Catolica de Chile School of Engineering, and the generosity and support of the Sulo and Aileen Maki Endowment. We acknowledge the World Climate Research Programme's Working Group on Coupled Modelling, which is responsible for CMIP, and we thank the climate modelling groups (listed in Table I of this paper) for producing and making available their model output. For CMIP, the U.S. Department of Energy's Program for Climate Model Diagnosis and Intercomparison provides coordinating support and led development of software infrastructure in partnership with the Global Organization for Earth System Science Portals. The authors would like to dedicate this work to the memory of Dr Jim Deacon, who was a tireless voice for the conservation of desert fishes and the Devils Hole pupfish in particular. The views expressed in this article are those of the authors and do not necessarily reflect any positions of the United States government. NR 40 TC 1 Z9 1 U1 16 U2 18 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1936-0584 EI 1936-0592 J9 ECOHYDROLOGY JI Ecohydrology PD JUN PY 2016 VL 9 IS 4 BP 560 EP 573 DI 10.1002/eco.1656 PG 14 WC Ecology; Environmental Sciences; Water Resources SC Environmental Sciences & Ecology; Water Resources GA DP5PS UT WOS:000378550200002 ER PT J AU Huh, J Easley, ME Nunley, JA AF Huh, Jeannie Easley, Mark E. Nunley, James A., II TI Characterization and Surgical Management of Achilles Tendon Sleeve Avulsions SO FOOT & ANKLE INTERNATIONAL LA English DT Article DE Achilles rupture; sleeve avulsion; suture anchor; insertional tendinopathy ID TRANSCALCANEAL SUTURE TECHNIQUE; CALCANEAL TUBEROSITY; FRACTURES; REPAIR; RUPTURE; ANATOMY; BONE; TIP AB Background: An Achilles sleeve avulsion occurs when the tendon ruptures distally from its calcaneal insertion as a continuous sleeve. This relatively rare injury pattern may not be appreciated until the time of surgery and can be challenging to treat because, unlike a midsubstance rupture, insufficient tendon remains on the calcaneus to allow for end-to-end repair, and unlike a tuberosity avulsion fracture, any bony element avulsed with the tendon is inadequate for internal fixation. This study aimed to highlight the characteristics of Achilles sleeve avulsions and present the outcomes of operative repair using suture anchor fixation. Methods: A retrospective analysis was conducted on 11 consecutive Achilles tendon sleeve avulsions (10 males, 1 female; mean age 44 years) that underwent operative repair between 2008 and 2014. Patient demographics, injury presentation, and operative details were reviewed. Postoperative outcomes were collected at a mean follow-up of 38.4 (range, 12-83.5) months, including the American Orthopaedic Foot & Ankle Society (AOFAS) Ankle-Hindfoot score, visual analog scale (VAS) for pain, plantarflexion strength, patient satisfaction, and complications. Results: Eight patients (72.7%) had preexisting symptoms of insertional Achilles disease. Ten of 11 (90.9%) injuries were sustained during recreational athletic activity. An Achilles sleeve avulsion was recognized preoperatively in 7 of 11 (64%) cases, where lateral ankle radiographs demonstrated a small radiodensity several centimeters proximal to the calcaneal insertion. Intraoperatively, 90.9% of sleeve avulsions had a concomitant Haglund deformity and macroscopic evidence of insertional tendinopathy. All patients healed after suture anchor repair. The average AOFAS score was 92.8 and VAS score was 0.9. Ten patients (90.9%) were completely satisfied. One complication occurred, consisting of delayed wound healing. Conclusions: Achilles tendon sleeve avulsions predominantly occurred in middle-aged men with preexisting insertional disease, while engaged in athletic activity. Suture anchor fixation, combined with addressing concomitant insertional pathology, was a reliable and safe technique for the operative management of Achilles tendon sleeve avulsions. The majority of patients returned to their preinjury levels of work and recreational activity. Level of Evidence: Level IV, retrospective case series. C1 [Huh, Jeannie] Dwight D Eisenhower Army Med Ctr, Dept Orthopaed Surg, 300 East Hosp Rd, Ft Gordon, GA 30905 USA. [Easley, Mark E.; Nunley, James A., II] Duke Univ, Med Ctr, Dept Orthopaed Surg, Durham, NC USA. RP Huh, J (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Orthopaed Surg, 300 East Hosp Rd, Ft Gordon, GA 30905 USA. EM jhandyh@gmail.com NR 31 TC 0 Z9 0 U1 0 U2 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1071-1007 EI 1944-7876 J9 FOOT ANKLE INT JI Foot Ankle Int. PD JUN PY 2016 VL 37 IS 6 BP 596 EP 604 DI 10.1177/1071100716629778 PG 9 WC Orthopedics SC Orthopedics GA DP3WC UT WOS:000378425600005 PM 26843543 ER PT J AU Eichinger, JK Galvin, JW Grassbaugh, JA Parada, SA Li, XN AF Eichinger, Josef K. Galvin, Joseph W. Grassbaugh, Jason A. Parada, Stephen A. Li, Xinning TI Glenoid Dysplasia Pathophysiology, Diagnosis, and Management SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME LA English DT Review ID POSTERIOR SHOULDER INSTABILITY; BONE BLOCK PROCEDURE; HUMERAL HEAD SUBLUXATION; GLENOHUMERAL JOINT; OSTEOARTHRITIS SECONDARY; COMPUTED-TOMOGRAPHY; SURGICAL-TREATMENT; JERK TEST; RECURRENT; HYPOPLASIA C1 [Eichinger, Josef K.; Galvin, Joseph W.; Grassbaugh, Jason A.] Madigan Army Med Ctr, Tacoma, WA 98431 USA. [Parada, Stephen A.] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA USA. Boston Univ, Sch Med, Boston, MA 02118 USA. [Li, Xinning] Boston Univ, Sch Med, Boston Med Ctr, Boston, MA 02118 USA. RP Eichinger, JK (reprint author), Madigan Army Med Ctr, Tacoma, WA 98431 USA. EM joe.eichinger@gmail.com; Joseph.w.galvin@gmail.com; grassbaugh@gmail.com; stephen.a.parada@gmail.com; Xinning.li@gmail.com NR 72 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0021-9355 EI 1535-1386 J9 J BONE JOINT SURG AM JI J. Bone Joint Surg.-Am. Vol. PD JUN 1 PY 2016 VL 98 IS 11 BP 958 EP 968 DI 10.2106/JBJS.15.00916 PG 11 WC Orthopedics; Surgery SC Orthopedics; Surgery GA DP6ZK UT WOS:000378648500014 PM 27252441 ER PT J AU Getz, TM Montgomery, RK Bynum, JA Aden, JK Pidcoke, HF Cap, AP AF Getz, Todd M. Montgomery, Robbie K. Bynum, James A. Aden, James K. Pidcoke, Heather F. Cap, Andrew P. TI Storage of platelets at 4 degrees C in platelet additive solutions prevents aggregate formation and preserves platelet functional responses SO TRANSFUSION LA English DT Article ID COAT-DERIVED PLATELETS; FRESH WHOLE-BLOOD; 4 DEGREES-C; IN-VITRO; APHERESIS PLATELETS; COLD; REFRIGERATION; TRANSFUSION; TEMPERATURE; VIABILITY AB BACKGROUNDPlatelet (PLT) storage has been limited to 5 days at room temperature due to metabolic decline and risk for bacterial contamination. Refrigeration preserves PLT metabolism and function as well as limits bacterial growth; however, cold storage of PLTs also leads to aggregate formation. We hypothesized that storage of PLT concentrates at 4 degrees C leads to glycoprotein (GP)IIb-IIIa activation and thus aggregate formation through fibrinogen binding and that this could be prevented by storing PLTs in PLT additive solution (PAS) without compromising PLT function. STUDY DESIGN AND METHODSApheresis PLTs in plasma (AP) or apheresis PLTs in PAS were stored at 22 or 4 degrees C for up to 15 days. Measurements include PLT counts, blood gases, aggregation response, flow cytometry analysis of integrin levels, activation markers, and microparticle formation. RESULTSStorage of AP 4 degrees C led to a gradual decline in PLT count and an increase in aggregate formation that was mediated by intracellular calcium leak and fibrinogen receptor activation. Storage of PAS at 4 degrees C prevented aggregate formation due to dilution of plasma fibrinogen. PAS stored at 4 degrees C maintained aggregation responses to multiple agonists better than 22 degrees C controls. CONCLUSIONStorage of AP at 4 degrees C leads to low level GPIIb-IIIa activation and results in aggregate formation over time. Separating the PLTs from the plasma component and storing them in PAS at 4 degrees C resolves aggregate formation and preserves the metabolic and functional responses of these stored PLTs. C1 [Getz, Todd M.; Montgomery, Robbie K.; Bynum, James A.; Aden, James K.; Pidcoke, Heather F.; Cap, Andrew P.] US Army, Inst Surg Res, San Antonio, TX USA. RP Cap, AP (reprint author), US Army, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM andrew.p.cap.mil@mail.mil FU US Army Medical Research Materiel Command FX Supported by the US Army Medical Research Materiel Command. NR 38 TC 3 Z9 3 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 EI 1537-2995 J9 TRANSFUSION JI Transfusion PD JUN PY 2016 VL 56 IS 6 BP 1320 EP 1328 DI 10.1111/trf.13511 PG 9 WC Hematology SC Hematology GA DP5QU UT WOS:000378553200041 PM 26853912 ER PT J AU Kuhn, JH Wiley, MR Rodriguez, SE Bao, YM Prieto, K da Rosa, APAT Guzman, H Savji, N Ladner, JT Tesh, RB Wada, J Jahrling, PB Bente, DA Palacios, G AF Kuhn, Jens H. Wiley, Michael R. Rodriguez, Sergio E. Bao, Yiming Prieto, Karla da Rosa, Amelia P. A. Travassos Guzman, Hilda Savji, Nazir Ladner, Jason T. Tesh, Robert B. Wada, Jiro Jahrling, Peter B. Bente, Dennis A. Palacios, Gustavo TI Genomic Characterization of the Genus Nairovirus (Family Bunyaviridae) SO VIRUSES-BASEL LA English DT Article DE Bunyaviridae; bunyavirus; nairovirus; Dera Ghazi Khan virus; Erve virus; Ganjam virus; Hughes virus; Qalyub virus; Sakhalin virus; Tunis virus; virus classification; virus taxonomy ID HEMORRHAGIC-FEVER-VIRUS; TICK-BORNE PHLEBOVIRUSES; HIDDEN MARKOV MODEL; PHYLOGENETIC CHARACTERIZATION; SAKHALIN-GROUP; GENETIC-CHARACTERIZATION; SEGMENT REASSORTMENT; ORNITHODOROS TICKS; SPECIES COMPLEX; IXODES-URIAE AB Nairovirus, one of five bunyaviral genera, includes seven species. Genomic sequence information is limited for members of the Dera Ghazi Khan, Hughes, Qalyub, Sakhalin, and Thiafora nairovirus species. We used next-generation sequencing and historical virus-culture samples to determine 14 complete and nine coding-complete nairoviral genome sequences to further characterize these species. Previously unsequenced viruses include Abu Mina, Clo Mor, Great Saltee, Hughes, Raza, Sakhalin, Soldado, and Tillamook viruses. In addition, we present genomic sequence information on additional isolates of previously sequenced Avalon, Dugbe, Sapphire II, and Zirqa viruses. Finally, we identify Tunis virus, previously thought to be a phlebovirus, as an isolate of Abu Hammad virus. Phylogenetic analyses indicate the need for reassignment of Sapphire II virus to Dera Ghazi Khan nairovirus and reassignment of Hazara, Tofla, and Nairobi sheep disease viruses to novel species. We also propose new species for the Kasokero group (Kasokero, Leopards Hill, Yogue viruses), the Ketarah group (Gossas, Issyk-kul, Keterah/soft tick viruses) and the Burana group (Wenzhou tick virus, Huangpi tick virus 1, Tacheng tick virus 1). Our analyses emphasize the sister relationship of nairoviruses and arenaviruses, and indicate that several nairo-like viruses (Shayang spider virus 1, Xinzhou spider virus, Sanxia water strider virus 1, South Bay virus, Wuhan millipede virus 2) require establishment of novel genera in a larger nairovirus-arenavirus supergroup. C1 [Kuhn, Jens H.; Wada, Jiro; Jahrling, Peter B.] NIAID, Integrated Res Facil Ft Detrick, Div Clin Res, NIH, Frederick, MD 21702 USA. [Wiley, Michael R.; Prieto, Karla; Ladner, Jason T.; Palacios, Gustavo] US Army, Ctr Genome Sci, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Rodriguez, Sergio E.; da Rosa, Amelia P. A. Travassos; Guzman, Hilda; Tesh, Robert B.; Bente, Dennis A.] Univ Texas Med Branch, Dept Microbiol & Immunol, Inst Human Infect & Immun, Galveston Natl Lab, Galveston, TX 77555 USA. [Bao, Yiming] NIH, Informat Engn Branch, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20892 USA. [Savji, Nazir] NYU, Sch Med, New York, NY 10016 USA. RP Palacios, G (reprint author), US Army, Ctr Genome Sci, Med Res Inst Infect Dis, Frederick, MD 21702 USA. EM kuhnjens@mail.nih.gov; michael.r.wiley19.ctr@mail.mil; seerodri@utmb.edu; bao@ncbi.nlm.nih.gov; karla.prieto.ctr@mail.mil; aptravas@utmb.edu; hguzman@utmb.edu; nazir.savji@gmail.com; jason.t.ladner.ctr@mail.mil; rtesh@utmb.edu; wadaj@mail.nih.gov; jahrlingp@niaid.nih.gov; dabente@utmb.edu; gustavo.f.palacios.ctr@mail.mil RI Palacios, Gustavo/I-7773-2015; OI Palacios, Gustavo/0000-0001-5062-1938; Kuhn, Jens H./0000-0002-7800-6045 FU Defense Threat Reduction Agency [1881290]; United States Department of Defense, Defense Biological Products Assurance Office; US National Institutes of Health (NIH) [HHSN272201000040I/HHSN27200004/D04]; Intramural Research Program of the NIH, National Library of Medicine; Battelle Memorial Institute; US National Institute of Allergy and Infectious Diseases (NIAID) [HHSN272200700016I] FX The content of this publication does not necessarily reflect the views or policies of the US Department of Health and Human Services, or the institutions and companies affiliated with the authors. This work was supported by the Defense Threat Reduction Agency #1881290, and the United States Department of Defense, Defense Biological Products Assurance Office. A.P.A.T.d.R., H.G., and R.B.T. were supported by US National Institutes of Health (NIH) contract HHSN272201000040I/HHSN27200004/D04. Y.B. was supported by the Intramural Research Program of the NIH, National Library of Medicine. This work was supported in part through Battelle Memorial Institute's prime contract with the US National Institute of Allergy and Infectious Diseases (NIAID) under Contract No. HHSN272200700016I. A Battelle employee involved in this work is: J.W. A subcontractor to Battelle Memorial Institute who performed this work is: J.H.K., an employee of Tunnell Government Services, Inc. We thank Laura Bollinger (Battelle Memorial Institute) for editing this manuscript. NR 128 TC 2 Z9 2 U1 2 U2 10 PU MDPI AG PI BASEL PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND SN 1999-4915 J9 VIRUSES-BASEL JI Viruses-Basel PD JUN PY 2016 VL 8 IS 6 AR 164 DI 10.3390/v8060164 PG 27 WC Virology SC Virology GA DP9WM UT WOS:000378848600016 ER PT J AU Amidon, WH Roden-Tice, M Anderson, AJ McKeon, RE Shuster, DL AF Amidon, W. H. Roden-Tice, M. Anderson, A. J. McKeon, R. E. Shuster, D. L. TI Late Cretaceous unroofing of the White Mountains, New Hampshire, USA: An episode of passive margin rejuvenation? SO GEOLOGY LA English DT Article ID LOW-TEMPERATURE THERMOCHRONOLOGY; FISSION-TRACK ANALYSIS; NORTHERN NEW-ENGLAND; AFRICAN RIFT SYSTEM; SOUTHERN AFRICA; ATLANTIC; STRESS; BRAZIL; REACTIVATION; EXHUMATION AB The growing recognition that many passive margins have experienced periods of post-rift uplift has raised new questions about the nature of the tectonic processes that drive such uplift. The eastern North America margin is of particular interest because it is a classic Atlanticstyle margin that has long been suspected of tectonic rejuvenation, yet the timing of post-rift uplift events remains elusive. To address this question we present apatite U-Th/He and fission track ages from a 1300 m vertical transect in the White Mountains of New Hampshire (USA), including a 910-m-deep bore hole. Thermal modeling suggests a period of accelerated denudation from ca. 85 to 65 Ma. This timing is broadly similar to the timing of accelerated exhumation and compression on passive margins elsewhere in the Atlantic, raising the question of whether a common mechanism, such as a change in lateral stresses, changes in mantle convection, or climate change, could be responsible. C1 [Amidon, W. H.; Anderson, A. J.] Middlebury Coll, Dept Geol, Middlebury, VT 05753 USA. [Roden-Tice, M.] SUNY Coll Plattsburgh, Ctr Earth & Environm Sci, Plattsburgh, NY 12901 USA. [McKeon, R. E.] US Army, Cold Reg Res & Engn Lab, Corps Engineers, Engineer Res & Dev Ctr, Hanover, NH 03755 USA. [Shuster, D. L.] Univ Calif Berkeley, Dept Earth & Planetary Sci, Berkeley, CA 94720 USA. RP Amidon, WH (reprint author), Middlebury Coll, Dept Geol, Middlebury, VT 05753 USA. NR 39 TC 0 Z9 0 U1 3 U2 3 PU GEOLOGICAL SOC AMER, INC PI BOULDER PA PO BOX 9140, BOULDER, CO 80301-9140 USA SN 0091-7613 EI 1943-2682 J9 GEOLOGY JI Geology PD JUN PY 2016 VL 44 IS 6 BP 415 EP 418 DI 10.1130/G37429.1 PG 4 WC Geology SC Geology GA DP0TW UT WOS:000378203600006 ER PT J AU Knox, J AF Knox, Jeffrey TI Epidemiology of spinal cord injury without radiographic abnormality in children: a nationwide perspective SO JOURNAL OF CHILDRENS ORTHOPAEDICS LA English DT Article DE Sciwora; Trauma; Spinal cord injury; Epidemiology ID YOUNG-CHILDREN; TRAUMA AB Purpose To characterize the epidemiology and costs associated with spinal cord injury without radiographic abnormality (SCIWORA) based on patient age. Methods An analysis of data complied for 2012 in the Healthcare Utilization Project KID database (HCUP-KID), which represents a nationwide database of pediatric admissions, was performed. An initial search identified all children diagnosed with SCIWORA based on International Classification of Diseases, 9th edition (ICD-9) codes. Only data on patients aged <18 years were included in the analysis. The associated codes were then searched to identify the cause of injury. Pertinent epidemiologic data were collected from the database, including age, gender, and racial group. Injury level and pattern were determined from the associated ICD-9 codes, as were associated injuries. Hospital data included length of stay, in-hospital mortality, total hospital charges, and primary payer. All data were compiled and stratified based on patient age into three groups: group 1, age 0-3 years; group 2, age 4-10 years; group 3, age 11-17 years. These data were compared using Student's t test and Chi-squared analyses. Results A total of 297 patients were identified who met the inclusion criteria. There was a slight predominance of females among the youngest patients (53 %) with a significant dominance of males in the oldest group (72 %) (p < 0.001). The most common race among the patients studied was white (50 %) followed by Hispanic (14 %), Black (12 %), Asian/Pacific Islander (4 %), and Native American (1 %). Overall, the most common cause of injury was sports injuries, which were responsible for 122/297 (41 %) injuries, followed by motor vehicle collisions (26 %). Mechanisms of injury were significantly varied based on age group, with motor vehicle collisions the most common cause in the youngest two age groups and sports injuries the most common in the oldest age group (p < 0.05). The most common location injured was the cervical spine (46 %), with the upper cervical spine most commonly injured, particularly in the younger age groups. Additional injuries were found in 158/297 (53 %) of patients, and these were more common among younger patients. Head trauma was the most common associated injury in all age groups, but the highest rate was found the youngest age groups (p < 0.0001). The average hospital stay for all patients was 13 days, with longer stays seen in younger age groups (p < 0.05). In-hospital mortality was uncommon among these patients and occurred in only 6/297 (2 %) of patients. Hospital charges were highest in the younger age groups, with an average charge of $210,772 for those in the youngest age group, decreasing to $72,178 for those in group 3 (p < 0.0005). The most common payer was public insurance/medicaid in the youngest age group and private insurance in groups 2 and 3 (p < 0.0001). Conclusions SCIWORA is an uncommon but potentially devastating injury in children. As with many pediatric injuries, this injury is heterogeneous between children of differing ages. This analysis of a nationwide series of children with such injuries identified significant differences in injury location, causes of injury, associated injuries, and hospital charges associated with this diagnosis. C1 [Knox, Jeffrey] Tripler Army Med Ctr, Orthoped Surg Serv MCHK DSO, 1 Jarrett White Rd, Honolulu, HI 96859 USA. RP Knox, J (reprint author), Tripler Army Med Ctr, Orthoped Surg Serv MCHK DSO, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM jeffrey.b.knox.mil@mail.mil NR 17 TC 0 Z9 0 U1 1 U2 1 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1863-2521 EI 1863-2548 J9 J CHILD ORTHOP JI J. Child. Orthop. PD JUN PY 2016 VL 10 IS 3 BP 255 EP 260 DI 10.1007/s11832-016-0740-x PG 6 WC Orthopedics SC Orthopedics GA DP0DX UT WOS:000378159300012 PM 27209042 ER PT J AU Clemens, BJ Spangler, JJ Robertson, PL Galovich, GM Banner, CR Gunckel, SL Ketchum, LL Bowden, RK Spagnoli, ST Kent, ML Kirk, JP AF Clemens, Benjamin J. Spangler, John J. Robertson, Paul L. Galovich, Gary M. Banner, Craig R. Gunckel, Stephanie L. Ketchum, Lindsay L. Bowden, R. Kanani Spagnoli, Sean T. Kent, Michael L. Kirk, James P. TI Persistence of Triploid Grass Carp in Devils Lake, Oregon SO JOURNAL OF FISH AND WILDLIFE MANAGEMENT LA English DT Article DE Asian carp; gonadal histology; intersex; maximum age; sterile ID BIGHEAD CARP; ESTABLISHMENT; RESERVOIRS; PRECISION; INTERSEX; RIVER; AGE AB Grass carp Ctenopharyngodon idella are sometimes used as a biological tool for managing aquatic vegetation in reservoirs. Sterile, triploid fish were stocked in Devils Lake, Oregon, during 1986, 1987, and 1993 to control aquatic vegetation. We present a case study for using multiple measures on the same fish to determine whether illegal stocking of fertile, diploid grass carp occurred. An investigation into the estimated age of a dead grass carp found in Devils Lake suggested that it was significantly younger than would otherwise be expected, given the only stocking events occurred during 1986, 1987, and 1993. To determine whether illegal stocking or reproduction by presumed sterile grass carp had occurred in Devils Lake, we conducted a study that balanced the needs of lethally sampling grass carp for biological measures with the socially and politically sensitive sentiment of the pro-grass carp citizenry of Devils Lake. These considerations, in combination with a low catch per-unit effort, resulted in a modest sample size for grass carp. We sampled grass carp and recorded multiple measures for each fish. Ploidy testing of blood samples indicated the grass carp were all triploid. Based on gonadal histopathology, six fish were male, two were female, and two were sex-indeterminate with severe gonadal dysgenesis. Age estimates from lapillus otoliths were consistent with fish originating from the legal stocking events in Devils Lake. The grass carp were 21-30 y old, and we were unable to find published reports of grass carp anywhere else in the world that are older. The grass carp were significantly smaller than much younger fish from other regions. The small size of these grass carp relative to their age in Devils Lake suggests food limitations that stunted growth. The dead grass carp that was the impetus for this study was aged by anatomical structures that we have since found to be unreliable. This suggests that the dead grass carp was probably in fact older and originated from the legal stockings. The use of multiple biological measurements on a modest sample size of grass carp, combined with the knowledge that no juvenile grass carp have been observed since legal stocking occurred, lead us to conclude that the grass carp in Devils Lake are sterile fish that originated from legal stocking events. C1 [Clemens, Benjamin J.; Gunckel, Stephanie L.; Ketchum, Lindsay L.; Bowden, R. Kanani] Oregon Dept Fish & Wildlife, 28655 Highway 34, Corvallis, OR 97333 USA. [Spangler, John J.] Oregon Dept Fish & Wildlife, 810 SW Alder St,Unit C, Newport, OR 97365 USA. [Robertson, Paul L.] Devils Lake Water Improvement Dist, POB 974, Lincoln City, OR 97367 USA. [Galovich, Gary M.] Oregon Dept Fish & Wildlife, 4034 Fairview Ind Dr SE, Salem, OR 97302 USA. [Banner, Craig R.] Oregon State Univ, Oregon Dept Fish & Wildlife, Corvallis, OR 97331 USA. [Banner, Craig R.] Oregon State Univ, Dept Microbiol, Corvallis, OR 97331 USA. [Spagnoli, Sean T.; Kent, Michael L.] Oregon State Univ, Dept Microbiol, Corvallis, OR 97331 USA. [Kirk, James P.] Engn Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. RP Clemens, BJ (reprint author), Oregon Dept Fish & Wildlife, 28655 Highway 34, Corvallis, OR 97333 USA. EM Ben.Clemens@oregonstate.edu FU Oregon Department of Fish and Wildlife's Restoration and Enhancement funds FX Equipment used for processing fish tissues for age estimates was procured through a grant from the Oregon Department of Fish and Wildlife's Restoration and Enhancement funds. Use of trade names does not constitute endorsement. M. Terwilliger provided technical guidance and assistance, including a separate age estimation of the dead grass carp that was the impetus for this study. B. Hickson of the Warm Springs Fish Health Center (U.S. Fish and Wildlife Service) conducted ploidy testing. D. Avery assisted with collection of fish. This manuscript benefitted from the thorough reviews of two editors and three reviewers. NR 29 TC 0 Z9 0 U1 7 U2 7 PU U S FISH & WILDLIFE SERVICE PI SHEPHERDSTOWN PA NATL CONSERVATION TRAINING CENTER, CONSERVATION LIBRARY, 698 CONSERVATION WAY, SHEPHERDSTOWN, WV 25443 USA SN 1944-687X J9 J FISH WILDL MANAG JI J. Fish Wildl. Manag. PD JUN PY 2016 VL 7 IS 1 BP 153 EP 161 DI 10.3996/042015-JFWM-044 PG 9 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA DO9CT UT WOS:000378082600014 ER PT J AU Glick, Y Fromzel, V Zhang, J Dahan, A Ter-Gabrielyan, N Pattnaik, RK Dubinskii, M AF Glick, Yaakov Fromzel, Viktor Zhang, Jun Dahan, Asaf Ter-Gabrielyan, Nikolay Pattnaik, Radha K. Dubinskii, Mark TI High power, high efficiency diode pumped Raman fiber laser SO LASER PHYSICS LETTERS LA English DT Article DE fiber laser; Raman laser; nonlinear optical fiber ID MULTIMODE FIBER; AMPLIFIER; SPECTRUM AB We demonstrate a high power high efficiency Raman fiber laser pumped directly by a laser diode module at 976 nm. 80 Watts of CW power were obtained at a wavelength of 1020 nm with an optical-to-optical efficiency of 53%. When working quasi-CW, at a duty cycle of 30%, 85 W of peak power was produced with an efficiency of 60%. A commercial graded-index (GRIN) core fiber acts as the Raman fiber in a power oscillator configuration, which includes spectral selection to prevent generation of the 2nd Stokes. In addition, significant brightness enhancement of the pump beam is attained due to the Raman gain distribution profile in the GRIN fiber. To the best of our knowledge, this is the highest power Raman fiber laser directly pumped by laser diodes, which also exhibits a record efficiency for such a laser. In addition, it is the highest power Raman fiber laser (regardless of pumping source) demonstrated based on a GRIN fiber. C1 [Glick, Yaakov; Fromzel, Viktor; Zhang, Jun; Ter-Gabrielyan, Nikolay; Pattnaik, Radha K.; Dubinskii, Mark] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Glick, Yaakov; Dahan, Asaf] Soreq Nucl Res Ctr, Div Appl Phys, IL-81800 Yavne, Israel. RP Glick, Y (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.; Glick, Y (reprint author), Soreq Nucl Res Ctr, Div Appl Phys, IL-81800 Yavne, Israel. EM yaakovgl@soreq.gov.il NR 18 TC 3 Z9 3 U1 4 U2 8 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 1612-2011 EI 1612-202X J9 LASER PHYS LETT JI Laser Phys. Lett. PD JUN PY 2016 VL 13 IS 6 AR 065101 DI 10.1088/1612-2011/13/6/065101 PG 6 WC Optics; Physics, Applied SC Optics; Physics GA DO7PR UT WOS:000377975000006 ER PT J AU Singh, J Haines, C AF Singh, Jogender Haines, Chris TI FIELD ASSISTED SINTERING TECHNOLOGY UPDATE-PART II SO ADVANCED MATERIALS & PROCESSES LA English DT Article C1 [Singh, Jogender] Penn State Univ, FASM, University Pk, PA 16801 USA. [Haines, Chris] US Army RDECOM ARDEC, Picatinny Arsenal, NJ USA. RP Singh, J (reprint author), Penn State Univ, Dept Mat Sci & Engn, FAST Ctr Excellence, University Pk, PA 16801 USA. EM jxs46@psu.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASM INT PI MATERIALS PARK PA SUBSCRIPTIONS SPECIALIST CUSTOMER SERVICE, MATERIALS PARK, OH 44073-0002 USA SN 0882-7958 EI 2161-9425 J9 ADV MATER PROCESS JI Adv. Mater. Process. PD JUN PY 2016 VL 174 IS 6 BP 22 EP 24 PG 3 WC Materials Science, Multidisciplinary SC Materials Science GA DO5UL UT WOS:000377848200007 ER PT J AU Taylor, S Messenger, S Folco, L AF Taylor, Susan Messenger, Scott Folco, Luigi TI Cosmic Dust: Finding a Needle in a Haystack SO ELEMENTS LA English DT Article DE micrometeorites; interplanetary dust particles (IDP); polar collections; stratospheric collections ID TRANSANTARCTIC MOUNTAINS; ACCRETION RATE; BLUE ICE; MICROMETEORITES; SPHERULES; ANTARCTICA; COLLECTION; DEBRIS; EARTH AB Collecting cosmic dust is a tricky business! Despite Earth's surface being showered by thousands of tons of comic dust every year, such dust is quickly lost in a sea of terrestrial particles. Finding the tiny cosmic treasures requires collecting dust from the cleanest environments where the terrestrial particle background is low. The stratosphere can be sampled via high-flying aircraft, whereas sampling cosmic dust from polar regions and the deep sea requires techniques that concentrate the particles. Collection efforts are worth it. Cosmic dust derives from every dust-producing object in the Solar System, including ancient Solar System materials, possibly even interstellar materials, of a type not found in meteorites. C1 [Taylor, Susan] US Army, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. [Messenger, Scott] NASA, Lyndon B Johnson Space Ctr, ARES, Houston, TX 77058 USA. [Folco, Luigi] Univ Pisa, Dept Sci Terra, Pisa, Italy. RP Taylor, S (reprint author), US Army, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM Susan.Taylor@erdc.dren.mil; scott.messenger@nasa.gov; luigi.folco@unipi.it NR 30 TC 4 Z9 4 U1 3 U2 3 PU MINERALOGICAL SOC AMER PI CHANTILLY PA 3635 CONCORDE PKWY STE 500, CHANTILLY, VA 20151-1125 USA SN 1811-5209 EI 1811-5217 J9 ELEMENTS JI Elements PD JUN PY 2016 VL 12 IS 3 BP 171 EP 176 DI 10.2113/gselements.12.3.171 PG 6 WC Geochemistry & Geophysics; Mineralogy SC Geochemistry & Geophysics; Mineralogy GA DO5UC UT WOS:000377847300003 ER PT J AU Olmo, HR Stokes, SM Foss, RD AF Olmo, Heather R. Stokes, Steven Marc Foss, Robert D. TI Olfactory Neuroblastoma: A Case Report SO HEAD & NECK PATHOLOGY LA English DT Article DE Olfactory neuroblastoma; Nasal cavity; Paranasal sinuses; Radiology; Homer Wright pseudorosettes; Flexner-Wintersteiner rosettes ID SINONASAL UNDIFFERENTIATED CARCINOMA; NEURO-BLASTOMA; ESTHESIONEUROBLASTOMA; NEOPLASMS; FEATURES AB A 43-year-old female presented with persistent nasal congestion with intermittent epistaxis without resolution for the preceding 5 years. Clinical examination revealed a large pink rubbery mass, medial to the middle turbinate in the right nasal cavity extending to the choana. Radiographic images demonstrated a heterogeneously enhancing lobular soft tissue mass filling the right nasal cavity, causing lateral bowing of the right medial orbital wall and extending posteriorly to the right anterior ethmoid sinus. The clinical, radiographic, histologic, and immunohistochemical features of olfactory neuroblastoma are discussed. C1 [Olmo, Heather R.] US Army, Off Surg Gen, Dent Corps, 7700 Arlington Blvd, Falls Church, VA 22042 USA. [Stokes, Steven Marc] Bur Med & Surg, Off Strategy Management, 7700 Arlington Blvd, Falls Church, VA 22042 USA. [Foss, Robert D.] Joint Pathol Ctr, Head & Neck Pathol, 606 Stephen Sitter Ave, Silver Spring, MD 20910 USA. RP Olmo, HR (reprint author), US Army, Off Surg Gen, Dent Corps, 7700 Arlington Blvd, Falls Church, VA 22042 USA. EM heather.r.olmo.mil@mail.mil; steven.m.stokes6.mil@mail.mil; robert.d.foss.ctr@mail.mil NR 15 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1936-055X EI 1936-0568 J9 HEAD NECK PATHOL JI Head Neck Pathol. PD JUN PY 2016 VL 10 IS 2 BP 256 EP 260 DI 10.1007/s12105-015-0649-6 PG 5 WC Pathology SC Pathology GA DO6KJ UT WOS:000377891800025 PM 26316323 ER PT J AU Tompkins, RP Khan, MR Green, R Jones, KA Leach, JH AF Tompkins, R. P. Khan, M. R. Green, R. Jones, K. A. Leach, J. H. TI IVT measurements of GaN power Schottky diodes with drift layers grown by HVPE on HVPE GaN substrates SO JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS LA English DT Article ID CURRENT-VOLTAGE CHARACTERISTICS; N-TYPE GAN; THIN-FILMS; SI AB To date, a majority of epitaxial layers for vertical gallium nitride (GaN) power Schottky diodes have been grown by metalorganic chemical vapor deposition. In this work, we investigate the electrical properties of vertical GaN Schottky diodes with drift layers grown by hydride vapor phase epitaxy (HVPE) on moderately-doped freestanding HVPE GaN substrates. Room temperature IV data is presented for devices tested where results for diode characteristics such as the breakdown voltage, V-b, specific on-resistance, Ron-sp, ideality factor, n, and barrier height, Phi(b), are measured for devices across the 1 cm 9 1 cm sample. The smallest diodes, which are 30 mu m in diameter, show the smallest specific on-resistance, whereas the breakdown voltage (defined as the voltage corresponding to a current of 10 mA cm(-2)) is independent of device size across the wafer. IV data show an average value of 1.06 +/- 0.06 for n and 0.80 +/- 0.04 eV for Phi(b) with little variation across the wafer, suggesting a reasonable metal-semiconductor interface across the entire sample. For one of the 300 mu m devices tested, we also examine the IV properties as function of temperature from 25 to 250 degrees C in increments of 25 degrees C and extract a zero temperature Phi(b) of 0.908 eV and Richardson's constant of 4.44 A cm(-2) K-2 which is significantly less than the theoretical value of 26.9 A cm(-2) K-2 C1 [Tompkins, R. P.; Khan, M. R.; Green, R.; Jones, K. A.] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Leach, J. H.] Kyma Technol, 8829 Midway West Rd, Raleigh, NC 27617 USA. RP Tompkins, RP (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM randy.tompkins.civ@mail.mil NR 27 TC 1 Z9 1 U1 9 U2 23 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0957-4522 EI 1573-482X J9 J MATER SCI-MATER EL JI J. Mater. Sci.-Mater. Electron. PD JUN PY 2016 VL 27 IS 6 BP 6108 EP 6114 DI 10.1007/s10854-016-4536-z PG 7 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Engineering; Materials Science; Physics GA DO6MQ UT WOS:000377898000082 ER PT J AU Hurtgen, BJ Ward, CL Garg, K Pollot, BE Goldman, SM McKinley, TO Wenke, JC Corona, BT AF Hurtgen, B. J. Ward, C. L. Garg, K. Pollot, B. E. Goldman, S. M. McKinley, T. O. Wenke, J. C. Corona, B. T. TI Severe muscle trauma triggers heightened and prolonged local musculoskeletal inflammation and impairs adjacent tibia fracture healing SO JOURNAL OF MUSCULOSKELETAL & NEURONAL INTERACTIONS LA English DT Article DE Skeletal Muscle Injury; Volumetric Muscle Loss; Trauma; Musculoskeletal; Inflammation; Innate; Adaptive; Immune Response; Composite Injury ID SKELETAL-MUSCLE; LOSS INJURY; FASCIOCUTANEOUS TISSUE; MUSCULAR-DYSTROPHY; BONE REGENERATION; EXTREMITY TRAUMA; IMMUNE-SYSTEM; T-CELLS; RATS; FIBROSIS AB Objectives: Complicated fracture healing is often associated with the severity of surrounding muscle tissue trauma. Since inflammation is a primary determinant of musculoskeletal health and regeneration, it is plausible that delayed healing and non-unions are partly caused by compounding local inflammation in response to concomitant muscle trauma. Methods and results: To investigate this possibility, a Lewis rat open fracture model [tibia osteotomy with adjacent tibialis anterior (TA) muscle volumetric muscle loss (VML) injury] was interrogated. We observed that VML injury impaired tibia healing, as indicated by diminished mechanical strength and decreased mineralized bone within the fracture callus, as well as continued presence of cartilage instead of woven bone 28 days post-injury. The VML injured muscle presented innate and adaptive immune responses that were atypical of canonical muscle injury healing. Additionally, the VML injury resulted in a perturbation of the inflammatory phase of fracture healing, as indicated by elevations of CD3(+) lymphocytes and CD68(+) macrophages in the fracture callus at 3 and 14d post-injury, respectively. Conclusions: These data indicate that heightened and sustained innate and adaptive immune responses to traumatized muscle are associated with impaired fracture healing and may be targeted for the prevention of delayed and non-union following musculoskeletal trauma. C1 [Hurtgen, B. J.; Ward, C. L.; Garg, K.; Pollot, B. E.; Goldman, S. M.; Wenke, J. C.; Corona, B. T.] US Army Inst Surg Res, Extrem Trauma & Regenerat Med Task Area, 3698 Chambers Pass,BHT1, Ft Sam Houston, TX 78234 USA. [McKinley, T. O.] Indiana Univ Sch Med, Dept Orthopaed Surg, Indianapolis, IN 46202 USA. RP Corona, BT (reprint author), US Army Inst Surg Res, Extrem Trauma & Regenerat Med Task Area, 3698 Chambers Pass,BHT1, Ft Sam Houston, TX 78234 USA. EM benjamin.t.corona.vol@mail.mil FU Combat Casualty Care Research Program, Medical Research and Materiel Command; Orthopaedic Trauma Association FX This work was supported by the Combat Casualty Care Research Program, Medical Research and Materiel Command (BTC) and the Orthopaedic Trauma Association (BTC & TOM). This work was performed as part of a service obligation to the NIH-LRP (BTC). BJH and CLW were post-doctoral fellows through the National Academy of Sciences during a portion of these studies. We thank Dr. Lisa Ji and Ms. Monica Jalomo for their technical assistance. NR 56 TC 2 Z9 2 U1 2 U2 4 PU JMNI PI NAFPLION PA 7 SPILIADOU SQ, NAFPLION, 21 100, GREECE SN 1108-7161 J9 J MUSCULOSKEL NEURON JI J. Musculoskelet. Neuronal Interact. PD JUN PY 2016 VL 16 IS 2 BP 122 EP 134 PG 13 WC Neurosciences; Physiology SC Neurosciences & Neurology; Physiology GA DO5IF UT WOS:000377816100005 PM 27282456 ER PT J AU Ponlawat, A Kankaew, P Chanaimongkol, S Pongsiri, A Richardson, JH Evans, BP AF Ponlawat, Alongkot Kankaew, Prasan Chanaimongkol, Somporn Pongsiri, Arissara Richardson, Jason H. Evans, Brian P. TI SEMI-FIELD EVALUATION OF METOFLUTHRIN-IMPREGNATED NETS ON HOST-SEEKING AEDES AEGYPTI AND ANOPHELES DIRUS SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article DE Aedes aegypti; Anopheles dirus; metofluthrin; mosquito control; spatial repellent ID SPATIAL REPELLENCY; FIELD-EVALUATION; PLASTIC STRIPS; MALARIA CONTROL; ENTOMOLOGICAL EVALUATION; PERSONAL PROTECTION; EXPERIMENTAL HUTS; MOSQUITO NETS; PAPER STRIP; INSECTICIDE AB The efficacy of a metofluthrin-impregnated net (MIN) known as the "Mushikonazu" on the house entry behavior of female Aedes aegypti and Anopheles dirus mosquitoes was evaluated using a semi-field 50-m tunnel setup. While the MIN is labeled for the control of chironomids and moth flies, this study determined the feasibility of using the device, given its current construction and metofluthrin formulation, as a spatial repellent against mosquitoes. Sentinel and cone bioassays were used to determine the insecticidal effect of the MIN. A spatial activity index (SAI) was calculated to evaluate responses of the mosquitoes. For the spatial repellent evaluation against Ae. aegypti, the overall mean of SAI was slightly less than 0 at wk 1 after the MIN application and then decreased for the last 4 wk showing a preference to treatment tent. For An. dirus, the mean SAI at wk 1 was positive, indicating a presumed repellent effect of the MIN against An. dirus. For the subsequent 4 wk, the SAI was negative, indicating a preference for the MIN. Results suggested that the MIN may not be a promising approach to repel Ae. aegypti and An. dirus under field conditions in Thailand. However, it remains probable that the MIN may be effective as a spatial repellent if modifications are made to the metofluthrin concentration or formulation and/or the construction of the device. C1 [Ponlawat, Alongkot; Kankaew, Prasan; Chanaimongkol, Somporn; Pongsiri, Arissara] Armed Forces Res Inst Med Sci AFRIMS, Dept Entomol, Bangkok 10400, Thailand. [Richardson, Jason H.] Armed Forces Pest Management Board, Silver Spring, MD 20910 USA. [Evans, Brian P.] US Army Med Dept Ctr & Sch, Environm Hlth Branch, San Antonio, TX 78234 USA. RP Ponlawat, A (reprint author), Armed Forces Res Inst Med Sci AFRIMS, Dept Entomol, Bangkok 10400, Thailand. FU Military Infectious Disease Research Program-Identification and Control of Insect Vectors of Infectious Diseases (Task Area U) FX We acknowledge the excellent support of Siriporn Phasomkusolsil and the Insectary staff, Department of Entomology, Armed Forces Research Institute of Medical Sciences. We thank John P. Grieco and Nicole L. Achee, University of Notre Dame, for guidance and suggestions on the experimental design. Also, we thank Ethan C. Degner from Cornell University for editorial assistance. This work was financially supported by the Military Infectious Disease Research Program-Identification and Control of Insect Vectors of Infectious Diseases (Task Area U). The views expressed herein are the private views of the authors and do not reflect the official views of the United States Army or the United States Department of Defense. NR 32 TC 1 Z9 1 U1 0 U2 2 PU AMER MOSQUITO CONTROL ASSOC PI MOUNT LAUREL PA 15000 COMMERCE PARKWAY, SUITE C, MOUNT LAUREL, NJ 08054 USA SN 8756-971X EI 1943-6270 J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD JUN PY 2016 VL 32 IS 2 BP 130 EP 138 PG 9 WC Entomology SC Entomology GA DO3YD UT WOS:000377717700007 PM 27280351 ER PT J AU Ross, JA Richie, DA Park, SJ Shires, DR AF Ross, James A. Richie, David A. Park, Song J. Shires, Dale R. TI Parallel programming model for the Epiphany many-core coprocessor using threaded MPI SO MICROPROCESSORS AND MICROSYSTEMS LA English DT Article DE 2D RISC array; MPI; NoC; Many-core; Adapteva Epiphany; Energy efficiency ID PROCESSOR; PERFORMANCE; ARCHITECTURES AB The Adapteva Epiphany many-core architecture comprises a 2D tiled mesh Network-on-Chip (NoC) of low-power RISC cores with minimal uncore functionality. It offers high computational energy efficiency for both integer and floating point calculations as well as parallel scalability. Yet despite the interesting architectural features, a compelling programming model has not been presented to date. This paper demonstrates an efficient parallel programming model for the Epiphany architecture based on the Message Passing Interface (MPI) standard. Using MPI exploits the similarities between the Epiphany architecture and a conventional parallel distributed cluster of serial cores. Our approach enables MPI codes to execute on the RISC array processor with little modification and achieve high performance. We report benchmark results for the threaded MPI implementation of four algorithms (dense matrix-matrix multiplication, N-body particle interaction, five-point 2D stencil update, and 2D FFT) and highlight the importance of fast inter-core communication for the architecture. Published by Elsevier B.V. C1 [Ross, James A.; Park, Song J.; Shires, Dale R.] US Army, Res Lab, Aberdeen Proving Ground, MD USA. [Richie, David A.] Brown Deer Technol, Forest Hill, MD USA. RP Ross, JA (reprint author), US Army, Res Lab, Aberdeen Proving Ground, MD USA. EM james.a.ross176.civ@mail.mil; drichie@browndeertechnology.com; song.j.park.civ@mail.mil; dale.r.shires.civ@mail.mil FU U.S. Army Research Laboratory-hosted Department of Defense Supercomputing Resource Center FX The authors wish to acknowledge the U.S. Army Research Laboratory-hosted Department of Defense Supercomputing Resource Center for its support of this work. NR 35 TC 0 Z9 0 U1 2 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0141-9331 EI 1872-9436 J9 MICROPROCESS MICROSY JI Microprocess. Microsyst. PD JUN PY 2016 VL 43 SI SI BP 95 EP 103 DI 10.1016/j.micpro.2016.02.006 PG 9 WC Computer Science, Hardware & Architecture; Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Computer Science; Engineering GA DO4GT UT WOS:000377740500009 ER PT J AU Obodo, UC Epum, EA Platts, MH Seloff, J Dahlson, NA Velkovsky, SM Paul, SR Friedman, KL AF Obodo, Udochukwu C. Epum, Esther A. Platts, Margaret H. Seloff, Jacob Dahlson, Nicole A. Velkovsky, Stoycho M. Paul, Shira R. Friedman, Katherine L. TI Endogenous Hot Spots of De Novo Telomere Addition in the Yeast Genome Contain Proximal Enhancers That Bind Cdc13 SO MOLECULAR AND CELLULAR BIOLOGY LA English DT Article ID SACCHAROMYCES-CEREVISIAE TELOMERES; SINGLE-STRANDED-DNA; LENGTH REGULATION; CHROMOSOME ENDS; IN-VITRO; PROTEIN; MAINTENANCE; RECOMBINATION; RAP1P; IDENTIFICATION AB DNA double-strand breaks (DSBs) pose a threat to genome stability and are repaired through multiple mechanisms. Rarely, telomerase, the enzyme that maintains telomeres, acts upon a DSB in a mutagenic process termed telomere healing. The probability of telomere addition is increased at specific genomic sequences termed sites of repair-associated telomere addition (SiRTAs). By monitoring repair of an induced DSB, we show that SiRTAs on chromosomes V and IX share a bipartite structure in which a core sequence (Core) is directly targeted by telomerase, while a proximal sequence (Stim) enhances the probability of de novo telomere formation. The Stim and Core sequences are sufficient to confer a high frequency of telomere addition to an ectopic site. Cdc13, a single-stranded DNA binding protein that recruits telomerase to endogenous telomeres, is known to stimulate de novo telomere addition when artificially recruited to an induced DSB. Here we show that the ability of the Stim sequence to enhance de novo telomere addition correlates with its ability to bind Cdc13, indicating that natural sites at which telomere addition occurs at high frequency require binding by Cdc13 to a sequence 20 to 100 bp internal from the site at which telomerase acts to initiate de novo telomere addition. C1 [Obodo, Udochukwu C.; Epum, Esther A.; Platts, Margaret H.; Seloff, Jacob; Dahlson, Nicole A.; Velkovsky, Stoycho M.; Paul, Shira R.; Friedman, Katherine L.] Vanderbilt Univ, Dept Biol Sci, 221 Kirkland Hall, Nashville, TN 37235 USA. [Platts, Margaret H.] Duke Univ, Durham, NC USA. [Seloff, Jacob] US Mil Acad, New York, NY USA. [Dahlson, Nicole A.] UT Southwestern Med Ctr, Dallas, TX USA. [Velkovsky, Stoycho M.] SUNY Stony Brook, Dept Ecol & Evolut, Stony Brook, NY 11794 USA. [Paul, Shira R.] Uniformed Serv Univ Hlth Sci, Bethesda, MD USA. RP Friedman, KL (reprint author), Vanderbilt Univ, Dept Biol Sci, 221 Kirkland Hall, Nashville, TN 37235 USA. EM katherine.friedman@vanderbilt.edu FU Vanderbilt University Discovery Grant; Vanderbilt University International Scholar Program; National Science Foundation (NSF) [MCB-0721595] FX This work, including the efforts of Katherine L. Friedman, was funded by Vanderbilt University Discovery Grant. This work, including the efforts of Udochukwu C. Obodo, was funded by Vanderbilt University International Scholar Program. This work, including the efforts of Katherine L. Friedman, was funded by National Science Foundation (NSF) (MCB-0721595). NR 51 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0270-7306 EI 1098-5549 J9 MOL CELL BIOL JI Mol. Cell. Biol. PD JUN PY 2016 VL 36 IS 12 BP 1750 EP 1763 DI 10.1128/MCB.00095-16 PG 14 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA DO7BS UT WOS:000377937800003 PM 27044869 ER PT J AU Pusateri, A AF Pusateri, A. TI RESEARCH AND DEVELOPMENT CHALLENGES FOR NEXT GENERATION RESUSCITATION SO SHOCK LA English DT Meeting Abstract CT 39th Annual Conference of the Shock-Society on Shock CY JUN 11-14, 2016 CL Austin, TX SP Shock Soc C1 [Pusateri, A.] US Army Med Res & Mat Command, Ft Detrick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2016 VL 45 IS 6 SU 1 MA 4 BP 14 EP 14 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA DO3OX UT WOS:000377692000005 ER PT J AU Lewis, A Wu, X Darlington, D Cap, A Schwacha, M AF Lewis, A. Wu, X. Darlington, D. Cap, A. Schwacha, M. TI TOLL-LIKE RECEPTOR-MEDIATED REGULATION OF PLATELET FUNCTION SO SHOCK LA English DT Meeting Abstract CT 39th Annual Conference of the Shock-Society on Shock CY JUN 11-14, 2016 CL Austin, TX SP Shock Soc C1 [Lewis, A.; Schwacha, M.] Univ Texas Hlth Sci Ctr San Antonio, Surg, San Antonio, TX 78229 USA. [Wu, X.; Darlington, D.; Cap, A.; Schwacha, M.] US Army Inst Surg Res, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2016 VL 45 IS 6 SU 1 MA P26 BP 53 EP 53 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA DO3OX UT WOS:000377692000119 ER PT J AU Schaub, LJ Cap, A Macko, AR Crossland, R Glaser, J Sheppard, FR AF Schaub, L. J. Cap, A. Macko, A. R. Crossland, R. Glaser, J. Sheppard, F. R. TI THE DURATION OF HEMORRHAGIC SHOCK DIRECTLY CORRELATES WITH THE SEVERITY OF TRAUMA INDUCED COAGULOPATHY (TIC) IN A RHESUS MACAQUE (NHP) MODEL OF SEVERE HEMORRHAGIC SHOCK SO SHOCK LA English DT Meeting Abstract CT 39th Annual Conference of the Shock-Society on Shock CY JUN 11-14, 2016 CL Austin, TX SP Shock Soc C1 [Cap, A.] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Schaub, L. J.; Macko, A. R.; Crossland, R.; Glaser, J.; Sheppard, F. R.] Naval Med Res Unit San Antonio, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2016 VL 45 IS 6 SU 1 MA P28 BP 53 EP 54 PG 2 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA DO3OX UT WOS:000377692000121 ER PT J AU Dubick, MA Prince, MD Polykratis, IA DeGuzman, R Sondeen, JL AF Dubick, M. A. Prince, M. D. Polykratis, I. A. DeGuzman, R. Sondeen, J. L. TI INFLUENCE OF BLOOD PRODUCT INFUSION RATES ON SURVIVAL IN SWINE SUBJECTED TO UNCONTROLLED HEMORRHAGE SO SHOCK LA English DT Meeting Abstract CT 39th Annual Conference of the Shock-Society on Shock CY JUN 11-14, 2016 CL Austin, TX SP Shock Soc C1 [Dubick, M. A.; Prince, M. D.; Polykratis, I. A.; DeGuzman, R.; Sondeen, J. L.] US Army Inst Surg Res, DCR, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2016 VL 45 IS 6 SU 1 MA P30 BP 54 EP 54 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA DO3OX UT WOS:000377692000123 ER PT J AU Reddoch, K Montgomery, R Ramasubramanian, A Cap, A AF Reddoch, K. Montgomery, R. Ramasubramanian, A. Cap, A. TI PLATELET ADDITIVE SOLUTION (PAS) AND STORAGE AT 4 degrees C PROTECT PLATELETS FROM INDUCTION OF APOPTOSIS COMPARED TO STORAGE AT ROOM TEMPERATURE OR IN PLASMA: FEASIBILITY OF 15-DAY PLATELET STORAGE SO SHOCK LA English DT Meeting Abstract CT 39th Annual Conference of the Shock-Society on Shock CY JUN 11-14, 2016 CL Austin, TX SP Shock Soc C1 [Ramasubramanian, A.] UTSA, San Antonio, TX USA. [Reddoch, K.; Montgomery, R.; Cap, A.] US Army Inst Surg Res, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2016 VL 45 IS 6 SU 1 MA P34 BP 56 EP 56 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA DO3OX UT WOS:000377692000127 ER PT J AU Torres, I Torres, LN Valdez, C Salgado, CL Cap, A Dubick, MA AF Torres Filho, I. Torres, L. N. Valdez, C. Salgado, C. L. Cap, A. Dubick, M. A. TI COLD-STORED PLATELETS STUDIED IN NORMOVOLEMIC AND HEMORRHAGED RATS USING CONFOCAL INTRAVITAL VIDEOMICROSCOPY SO SHOCK LA English DT Meeting Abstract CT 39th Annual Conference of the Shock-Society on Shock CY JUN 11-14, 2016 CL Austin, TX SP Shock Soc C1 [Torres Filho, I.; Torres, L. N.; Valdez, C.; Salgado, C. L.; Cap, A.; Dubick, M. A.] US Army, Inst Surg Res, Damage Control Resuscitat, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2016 VL 45 IS 6 SU 1 MA P42 BP 59 EP 59 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA DO3OX UT WOS:000377692000135 ER PT J AU Torres, LN Salgado, CL Xia, H Dubick, MA Torres, I AF Torres, L. N. Salgado, C. L. Xia, H. Dubick, M. A. Torres Filho, I. TI RESUSCITATION WITH LOW VOLUME ADJUNCTS COMBINED WITH LACTATED RINGER'S PROMOTES ENDOTHELIAL GLYCOCALYX (EG) RECOVERY IN VIVO DURING HEMORRHAGIC SHOCK IN RATS SO SHOCK LA English DT Meeting Abstract CT 39th Annual Conference of the Shock-Society on Shock CY JUN 11-14, 2016 CL Austin, TX SP Shock Soc C1 [Torres, L. N.; Salgado, C. L.; Xia, H.; Dubick, M. A.; Torres Filho, I.] US Army, Inst Surg Res, Damage Control Resuscitat, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2016 VL 45 IS 6 SU 1 MA P46 BP 60 EP 61 PG 2 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA DO3OX UT WOS:000377692000139 ER PT J AU Burmeister, DM Baker, B McIntyre, M Natesan, S Christy, R AF Burmeister, D. M. Baker, B. McIntyre, M. Natesan, S. Christy, R. TI CHARACTERIZATION OF SYSTEMIC INFLAMMATION AND THE EFFECTS ON DISTANT ORGANS AFTER EXTENSIVE CONTACT BURNS IN SWINE SO SHOCK LA English DT Meeting Abstract CT 39th Annual Conference of the Shock-Society on Shock CY JUN 11-14, 2016 CL Austin, TX SP Shock Soc C1 [Burmeister, D. M.; Baker, B.; McIntyre, M.; Natesan, S.; Christy, R.] US Army Inst Surg Res, Damage Control Resuscitat, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2016 VL 45 IS 6 SU 1 MA P94 BP 80 EP 81 PG 2 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA DO3OX UT WOS:000377692000187 ER PT J AU Macko, AR Cap, A Schaub, LJ Crossland, R Hemond, P Glaser, J Sheppard, FR AF Macko, A. R. Cap, A. Schaub, L. J. Crossland, R. Hemond, P. Glaser, J. Sheppard, F. R. TI EFFECTS OF POLYTRAUMATIC INJURY WITH HEMORRHAGIC SHOCK ON COAGULATION SYSTEM FUNCTION IN A NON-HUMAN PRIMATE (RHESUS MACAQUE) MODEL SO SHOCK LA English DT Meeting Abstract CT 39th Annual Conference of the Shock-Society on Shock CY JUN 11-14, 2016 CL Austin, TX SP Shock Soc C1 [Macko, A. R.; Schaub, L. J.; Crossland, R.; Hemond, P.; Glaser, J.; Sheppard, F. R.] Naval Med Res Unit San Antonio, Ft Sam Houston, TX USA. [Cap, A.] US Army Inst Surg Res, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2016 VL 45 IS 6 SU 1 MA P114 BP 89 EP 89 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA DO3OX UT WOS:000377692000207 ER PT J AU Cannon, JW Hurst, K Brostoff, N Namas, R Cotton, B Schreiber, M Chung, K Chang, S Cap, A Vodovotz, Y AF Cannon, J. W. Hurst, K. Brostoff, N. Namas, R. Cotton, B. Schreiber, M. Chung, K. Chang, S. Cap, A. Vodovotz, Y. TI TRAUMA IN SILICO: A COMPUTATIONAL MODEL OF ACUTE HEMORRHAGE, COAGULOPATHY, AND RESUSCITATION SO SHOCK LA English DT Meeting Abstract CT 39th Annual Conference of the Shock-Society on Shock CY JUN 11-14, 2016 CL Austin, TX SP Shock Soc C1 [Cannon, J. W.] Univ Penn, Surg, Philadelphia, PA 19104 USA. [Hurst, K.; Brostoff, N.; Chang, S.] Immunetrics, Pittsburgh, PA USA. [Namas, R.; Vodovotz, Y.] Univ Pittsburgh, Pittsburgh, PA USA. [Chung, K.; Cap, A.] US Army Inst Surg Res, JBSA Ft Sam Houston, Ft Sam Houston, TX USA. [Cotton, B.] Univ Texas Hlth Sci Ctr Houston, Houston, TX 77030 USA. [Schreiber, M.] Oregon Hlth & Sci Univ, Portland, OR 97201 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2016 VL 45 IS 6 SU 1 MA P116 BP 90 EP 90 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA DO3OX UT WOS:000377692000209 ER PT J AU Martini, WZ DeGuzman, R Rodriguez, C Bice, L Polykratis, IA Cap, A Dubick, MA AF Martini, W. Z. DeGuzman, R. Rodriguez, C. Bice, L. Polykratis, I. A. Cap, A. Dubick, M. A. TI FIBRINOGEN CONCENTRATE STABILITY UNDER DIFFERENT TEMPERATURES AND DURATIONS SO SHOCK LA English DT Meeting Abstract CT 39th Annual Conference of the Shock-Society on Shock CY JUN 11-14, 2016 CL Austin, TX SP Shock Soc C1 [Martini, W. Z.; DeGuzman, R.; Rodriguez, C.; Bice, L.; Polykratis, I. A.; Cap, A.; Dubick, M. A.] US Army Inst Surg Res, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2016 VL 45 IS 6 SU 1 MA P121 BP 92 EP 92 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA DO3OX UT WOS:000377692000214 ER PT J AU Wu, X Benov, A Liu, B Keesee, JD Schwacha, MG Cap, A Darlington, DN AF Wu, X. Benov, A. Liu, B. Keesee, J. D. Schwacha, M. G. Cap, A. Darlington, D. N. TI RESUSCITATION WITH TRANEXAMIC ACID AND FRESH WHOLE BLOOD REDUCES THE SEVERITY OF ACUTE LUNG INJURY AFTER POLYTRAUMA AND HEMORRHAGE IN RAT SO SHOCK LA English DT Meeting Abstract CT 39th Annual Conference of the Shock-Society on Shock CY JUN 11-14, 2016 CL Austin, TX SP Shock Soc C1 [Wu, X.; Benov, A.; Liu, B.; Keesee, J. D.; Schwacha, M. G.; Cap, A.; Darlington, D. N.] US Army Inst Surg Res, San Antonio, TX USA. [Wu, X.; Schwacha, M. G.; Cap, A.; Darlington, D. N.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Benov, A.] Israel Def Forces Med Corps, Tel Hashomer, Israel. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2016 VL 45 IS 6 SU 1 MA P138 BP 99 EP 99 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA DO3OX UT WOS:000377692000231 ER PT J AU Li, Y Sheppard, FR Liu, B Dubick, MA Cancio, LC Dallelucca, J AF Li, Y. Sheppard, F. R. Liu, B. Dubick, M. A. Cancio, L. C. Dallelucca, J. TI GAMMA DELTA T LYMPHOCYTE INFILTRATION CONTRIBUTES TO HEMORRHAGIC SHOCK-INDUCED PULMONARY INJURY IN RATS SO SHOCK LA English DT Meeting Abstract CT 39th Annual Conference of the Shock-Society on Shock CY JUN 11-14, 2016 CL Austin, TX SP Shock Soc C1 [Li, Y.; Liu, B.; Dubick, M. A.; Cancio, L. C.] US Army Inst Surg Res, Task Area Multiple Organ Support Technol, Jbsa Ft Sam Houston, TX USA. [Sheppard, F. R.] Naval Med Res Unit San Antonio, Jbsa Ft Sam Houston, TX USA. [Dallelucca, J.] Dept Def Threat Reduct Agcy, Ft Belvoir, VA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2016 VL 45 IS 6 SU 1 MA P194 BP 119 EP 119 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA DO3OX UT WOS:000377692000286 ER PT J AU Walters, TJ AF Walters, T. J. TI HEMORRHAGIC SHOCK AND RESUSCITATION EXACERBATE TOURNIQUET INDUCED ISCHEMIA REPERFUSION MUSCLE FIBER DAMAGE SO SHOCK LA English DT Meeting Abstract CT 39th Annual Conference of the Shock-Society on Shock CY JUN 11-14, 2016 CL Austin, TX SP Shock Soc C1 [Walters, T. J.] US Army Inst Surg Res, Extrem Trauma & Regenerat Med, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2016 VL 45 IS 6 SU 1 MA P198 BP 120 EP 121 PG 2 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA DO3OX UT WOS:000377692000290 ER PT J AU Antebi, B McDaniel, JS Cancio, LC Batchinsky, AI AF Antebi, B. McDaniel, J. S. Cancio, L. C. Batchinsky, A. I. TI QUANTITATIVE ASSESSMENT OF OPTIMAL BONE MARROW SITE FOR THE ISOLATION OF MESENCHYMAL STEM CELLS SO SHOCK LA English DT Meeting Abstract CT 39th Annual Conference of the Shock-Society on Shock CY JUN 11-14, 2016 CL Austin, TX SP Shock Soc C1 [Antebi, B.; McDaniel, J. S.; Cancio, L. C.; Batchinsky, A. I.] US Army Inst Surg Res, MOST, Jbsa Ft Sam Houston, TX USA. [Antebi, B.; Batchinsky, A. I.] Geneva Fdn, Tacoma, WA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2016 VL 45 IS 6 SU 1 MA P237 BP 134 EP 134 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA DO3OX UT WOS:000377692000329 ER PT J AU Beely, BM Antebi, B Walker, KP Cancio, LC Batchinsky, AI AF Beely, B. M. Antebi, B. Walker, K. P. Cancio, L. C. Batchinsky, A. I. TI FEASIBILITY OF DELIVERING MESENCHYMAL STEM CELLS VIA AEROSOLIZATION: AN EX VIVO STUDY SO SHOCK LA English DT Meeting Abstract CT 39th Annual Conference of the Shock-Society on Shock CY JUN 11-14, 2016 CL Austin, TX SP Shock Soc C1 [Beely, B. M.; Antebi, B.; Walker, K. P.; Cancio, L. C.; Batchinsky, A. I.] US Army Inst Surg Res, Multiorgan Support Technol, San Antonio, TX USA. [Beely, B. M.; Antebi, B.; Batchinsky, A. I.] Geneva Fdn, Tacoma, WA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2016 VL 45 IS 6 SU 1 MA P238 BP 134 EP 135 PG 2 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA DO3OX UT WOS:000377692000330 ER PT J AU Ketter, P Ainsworth, S Arulanandam, B Cap, A AF Ketter, P. Ainsworth, S. Arulanandam, B. Cap, A. TI THIOREDOXIN: A MODULATOR OF MULTI-DRUG RESISTANT ACINETOBACTER BAUMANNII SEPSIS SO SHOCK LA English DT Meeting Abstract CT 39th Annual Conference of the Shock-Society on Shock CY JUN 11-14, 2016 CL Austin, TX SP Shock Soc C1 [Ketter, P.; Cap, A.] US Army Inst Surg Res, Coagulat & Blood Res, Jbsa Ft Sam Houston, TX USA. [Ainsworth, S.; Arulanandam, B.] Univ Texas San Antonio, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2016 VL 45 IS 6 SU 1 MA P245 BP 137 EP 138 PG 2 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA DO3OX UT WOS:000377692000337 ER PT J AU Torres, IP Torres, LN Salgado, C Dubick, MA AF Torres Filho, Ivo P. Torres, Luciana N. Salgado, Christi Dubick, Michael A. TI Plasma syndecan-1 and heparan sulfate correlate with microvascular glycocalyx degradation in hemorrhaged rats after different resuscitation fluids SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY LA English DT Article DE hemorrhage; resuscitation; microcirculation; glycocalyx; syndecan; muscle; shock ID ISCHEMIA-REPERFUSION INJURY; ENDOTHELIAL SURFACE-LAYER; BLOOD-FLOW; IN-VIVO; VENULAR GLYCOCALYX; THERAPEUTIC TARGET; TRAUMA PATIENTS; SHOCK; INFLAMMATION; BARRIER AB The endothelial glycocalyx plays an essential role in many physiological functions and is damaged after hemorrhage. Fluid resuscitation may further change the glycocalyx after an initial hemorrhage-induced degradation. Plasma levels of syndecan-1 and heparan sulfate have been used as indirect markers for glycocalyx degradation, but the extent to which these measures are representative of the events in the microcirculation is unknown. Using hemorrhage and a wide range of resuscitation fluids, we studied quantitatively the relationship between plasma biomarkers and changes in microvascular parameters, including glycocalyx thickness. Rats were bled 40% of total blood volume and resuscitated with seven different fluids (fresh whole blood, blood products, and crystalloids). Intravital microscopy was used to estimate glycocalyx thickness in >270 postcapillary venules from 58 cremaster preparations in 9 animal groups; other microvascular parameters were measured using noninvasive techniques. Systemic physiological parameters and blood chemistry were simultaneously collected. Changes in glycocalyx thickness were negatively correlated with changes in plasma levels of syndecan-1 (r = -0.937) and heparan sulfate (r = -0.864). Changes in microvascular permeability were positively correlated with changes in both plasma biomarkers (r = 0.8, P < 0.05). Syndecan-1 and heparan sulfate were also positively correlated (r = 0.7, P < 0.05). Except for diameter and permeability, changes in local microcirculatory parameters (red blood cell velocity, blood flow, and wall shear rate) did not correlate with plasma biomarkers or glycocalyx thickness changes. This work provides a quantitative framework supporting plasma syndecan-1 and heparan sulfate as valuable clinical biomarkers of glycocalyx shedding that may be useful in guiding resuscitation strategies following hemorrhage. C1 [Torres Filho, Ivo P.; Torres, Luciana N.; Salgado, Christi; Dubick, Michael A.] US Army, Inst Surg Res, Damage Control Resuscitat, Ft Sam Houston, TX 78234 USA. RP Torres, IP (reprint author), US Army, Inst Surg Res, 3650 Chambers Pass,BHT 2,Rm 282-1, Ft Sam Houston, TX 78234 USA. EM ivo.p.torresfilho.civ@mail.mil FU US Army Medical Research Materiel Command FX This study was supported by the US Army Medical Research Materiel Command. It was performed in part while I. P. Torres Filho and L. N. Torres were employed by Premier Consulting & Management Services and Cherokee Nation Businesses, respectively. NR 67 TC 0 Z9 0 U1 3 U2 5 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0363-6135 EI 1522-1539 J9 AM J PHYSIOL-HEART C JI Am. J. Physiol.-Heart Circul. Physiol. PD JUN 1 PY 2016 VL 310 IS 11 BP H1468 EP H1478 DI 10.1152/ajpheart.00006.2016 PG 11 WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular Disease SC Cardiovascular System & Cardiology; Physiology GA DN9XQ UT WOS:000377434400010 PM 27037369 ER PT J AU Koju, RK Darling, KA Kecskes, LJ Mishin, Y AF Koju, R. K. Darling, K. A. Kecskes, L. J. Mishin, Y. TI Zener Pinning of Grain Boundaries and Structural Stability of Immiscible Alloys SO JOM LA English DT Article ID CU-TA ALLOYS; NANOCRYSTALLINE ALLOYS; MOLECULAR-DYNAMICS; STABILIZATION; GROWTH; DRAG; MOTION; COPPER; SIMULATIONS; MIGRATION AB Immiscible Cu-Ta alloys produced by mechanical alloying are currently the subject of intensive research due to their mechanical strength combined with extraordinary structural stability at high temperatures. Previous experimental and simulation studies suggested that grain boundaries (GBs) in Cu-Ta alloys are stabilized by Ta nano-clusters coherent with the Cu matrix. To better understand the stabilization effect of Ta, we performed atomistic computer simulations of GB-cluster interactions in Cu-Ta alloys with various compositions and GB velocities. The study focuses on a single plane GB driven by an applied shear stress due to the shear-coupling effect. The results of the simulations are in close quantitative agreement with the Zener model of GB pinning. This agreement and the large magnitude of the unpinning stress confirm that the structural stability of these alloys is due to the drastically decreased GB mobility rather than a reduction in GB energy. For comparison, we simulated GB motion in a random solid solution. While the latter also reduces the GB mobility, the effect is not as strong as in the presence of Ta clusters. GB motion in the random solution itself induces precipitation of Ta clusters due to short-circuit diffusion of Ta in GBs, suggesting a possible mechanism of cluster formation inside the grains. C1 [Koju, R. K.; Mishin, Y.] George Mason Univ, Dept Phys & Astron, MSN 3F3, Fairfax, VA 22030 USA. [Darling, K. A.; Kecskes, L. J.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Mishin, Y (reprint author), George Mason Univ, Dept Phys & Astron, MSN 3F3, Fairfax, VA 22030 USA. EM ymishin@gmu.edu RI Mishin, Yuri/P-2020-2015 FU U.S. Army Research Office [W911NF-15-1-0077] FX R.KK. and Y. M. were supported by the U.S. Army Research Office under a Contract Number W911NF-15-1-0077. NR 39 TC 1 Z9 1 U1 6 U2 15 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1047-4838 EI 1543-1851 J9 JOM-US JI JOM PD JUN PY 2016 VL 68 IS 6 BP 1596 EP 1604 DI 10.1007/s11837-016-1899-9 PG 9 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering; Mineralogy; Mining & Mineral Processing SC Materials Science; Metallurgy & Metallurgical Engineering; Mineralogy; Mining & Mineral Processing GA DN9XI UT WOS:000377433600014 ER PT J AU Coleman, SP Hernandez-Rivera, E Behler, KD Synowczynski-Dunn, J Tschopp, MA AF Coleman, Shawn P. Hernandez-Rivera, Efrain Behler, Kristopher D. Synowczynski-Dunn, Jennifer Tschopp, Mark A. TI Challenges of Engineering Grain Boundaries in Boron-Based Armor Ceramics SO JOM LA English DT Article ID MOLECULAR-DYNAMICS SIMULATION; SILICON-NITRIDE CERAMICS; IMPROVED FRACTURE-TOUGHNESS; INTERGRANULAR GLASSY FILMS; REACTIVE FORCE-FIELD; MECHANICAL-PROPERTIES; CARBIDE B4C; MICROSTRUCTURAL DESIGN; ELASTIC PROPERTIES; NANOTUBES AB Boron-based ceramics are appealing for lightweight applications in both vehicle and personnel protection, stemming from their combination of high hardness, high elastic modulus, and low density as compared to other ceramics and metal alloys. However, the performance of these ceramics and ceramic composites is lacking because of their inherent low fracture toughness and reduced strength under high-velocity threats. The objective of the present article is to briefly discuss both the challenges and the state of the art in experimental and computational approaches for engineering grain boundaries in boron-based armor ceramics, focusing mainly on boron carbide (B4C) and boron suboxide (B6O). The experimental challenges involve processing these ceramics at full density while trying to promote microstructure features such as intergranular films to improve toughness during shock. Many of the computational challenges for boron-based ceramics stem from their complex crystal structure which has hitherto complicated the exploration of grain boundaries and interfaces. However, bridging the gaps between experimental and computational studies at multiple scales to engineer grain boundaries in these boron-based ceramics may hold the key to maturing these material systems for lightweight defense applications. C1 [Coleman, Shawn P.; Hernandez-Rivera, Efrain; Behler, Kristopher D.; Synowczynski-Dunn, Jennifer; Tschopp, Mark A.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Behler, Kristopher D.] TKC Global, Herndon, VA 20171 USA. RP Coleman, SP (reprint author), US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM shawn.p.coleman8.ctr@mail.mil; mark.a.tsch-opp.civ@mail.mil RI Tschopp, Mark/B-1594-2008 OI Tschopp, Mark/0000-0001-8471-5035 NR 99 TC 0 Z9 0 U1 9 U2 12 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1047-4838 EI 1543-1851 J9 JOM-US JI JOM PD JUN PY 2016 VL 68 IS 6 BP 1605 EP 1615 DI 10.1007/s11837-016-1856-7 PG 11 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering; Mineralogy; Mining & Mineral Processing SC Materials Science; Metallurgy & Metallurgical Engineering; Mineralogy; Mining & Mineral Processing GA DN9XI UT WOS:000377433600015 ER PT J AU Anthony, SM Rivas, SC Colpitts, SL Howard, ME Stonier, SW Schluns, KS AF Anthony, Scott M. Rivas, Sarai C. Colpitts, Sara L. Howard, Megan E. Stonier, Spencer W. Schluns, Kimberly S. TI Inflammatory Signals Regulate IL-15 in Response to Lymphodepletion SO JOURNAL OF IMMUNOLOGY LA English DT Article ID CD8(+) T-CELLS; IN-VIVO; TRANS-PRESENTATION; DENDRITIC CELLS; MICROBIAL TRANSLOCATION; SOLUBLE IL-15R-ALPHA; METASTATIC MELANOMA; IMMUNOGENIC TUMORS; NK CELLS; EXPRESSION AB Induction of lymphopenia has been exploited therapeutically to improve immune responses to cancer therapies and vaccinations. Whereas IL-15 has well-established roles in stimulating lymphocyte responses after lymphodepletion, the mechanisms regulating these IL-15 responses are unclear. We report that cell surface IL-15 expression is upregulated during lymphopenia induced by total body irradiation (TBI), cyclophosphamide, or Thy1 Ab-mediated T cell depletion, as well as in RAG(-/-) mice; interestingly, the cellular profile of surface IL-15 expression is distinct in each model. In contrast, soluble IL-15 (sIL-15) complexes are upregulated only after TBI or alpha Thy1 Ab. Analysis of cell-specific IL-15R alpha conditional knockout mice revealed that macrophages and dendritic cells are important sources of sIL-15 complexes after TBI but provide minimal contribution in response to Thy1 Ab treatment. Unlike with TBI, induction of sIL-15 complexes by aThy1 Ab is sustained and only partially dependent on type I IFNs. The stimulator of IFN genes pathway was discovered to be a potent inducer of sIL-15 complexes and was required for optimal production of sIL-15 complexes in response to Ab-mediated T cell depletion and TBI, suggesting products of cell death drive production of sIL-15 complexes after lymphodepletion. Lastly, we provide evidence that IL-15 induced by inflammatory signals in response to lymphodepletion drives lymphocyte responses, as memory CD8 T cells proliferated in an IL-15-dependent manner. Overall, these studies demonstrate that the form in which IL-15 is expressed, its kinetics and cellular sources, and the inflammatory signals involved are differentially dictated by the manner in which lymphopenia is induced. C1 [Anthony, Scott M.; Stonier, Spencer W.; Schluns, Kimberly S.] Univ Texas Houston, Grad Sch Biomed Sci, Grad Program Immunol, Houston, TX 77030 USA. [Anthony, Scott M.; Rivas, Sarai C.; Howard, Megan E.; Stonier, Spencer W.; Schluns, Kimberly S.] Univ Texas MD Anderson Canc Ctr, Dept Immunol, MC 902,POB 301429, Houston, TX 77030 USA. [Colpitts, Sara L.] Univ Connecticut, Hlth Sci Ctr, Dept Immunol, Farmington, CT 06030 USA. [Anthony, Scott M.] Univ Iowa, Dept Microbiol, Iowa City, IA 52242 USA. [Colpitts, Sara L.] Dartmouth Coll, Geisel Sch Med, Dept Microbiol & Immunol, Hanover, NH 03755 USA. [Stonier, Spencer W.] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Schluns, KS (reprint author), Univ Texas MD Anderson Canc Ctr, Dept Immunol, MC 902,POB 301429, Houston, TX 77030 USA. EM kschluns@mdanderson.org FU National Institutes of Health Predoctoral Training Grant [CA009598]; American Cancer Society [PF-11-152-01-LIB]; Center for Inflammation and Cancer at the MD Anderson Cancer Center; Center for Inflammation and Cancer at the MD Anderson Bridge funding FX This work was supported by National Institutes of Health Predoctoral Training Grant CA009598 (to S.M.A. and S.W.S.), Postdoctoral Fellowship PF-11-152-01-LIB from the American Cancer Society (to S.L.C.), and a seed fund from the Center for Inflammation and Cancer at the MD Anderson Cancer Center and MD Anderson Bridge funding (to K.S.S.). NR 49 TC 0 Z9 0 U1 2 U2 2 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 EI 1550-6606 J9 J IMMUNOL JI J. Immunol. PD JUN 1 PY 2016 VL 196 IS 11 BP 4544 EP 4552 DI 10.4049/jimmunol.1600219 PG 9 WC Immunology SC Immunology GA DO3IU UT WOS:000377676000014 PM 27183627 ER PT J AU Payne, RO Milne, KH Elias, SC Edwards, NJ Douglas, AD Brown, RE Silk, SE Biswas, S Miura, K Roberts, R Rampling, TW Venkatraman, N Hodgson, SH Labbe, GM Halstead, FD Poulton, ID Nugent, FL de Graaf, H Sukhtankar, P Williams, NC Ockenhouse, CF Kathcart, AK Qabar, AN Waters, NC Soisson, LA Birkett, AJ Cooke, GS Faust, SN Woods, C Ivinson, K McCarthy, JS Diggs, CL Vekemans, J Long, CA Hill, AVS Lawrie, AM Dutta, S Draper, SJ AF Payne, Ruth O. Milne, Kathryn H. Elias, Sean C. Edwards, Nick J. Douglas, Alexander D. Brown, Rebecca E. Silk, Sarah E. Biswas, Sumi Miura, Kazutoyo Roberts, Rachel Rampling, Thomas W. Venkatraman, Navin Hodgson, Susanne H. Labbe, Genevieve M. Halstead, Fenella D. Poulton, Ian D. Nugent, Fay L. de Graaf, Hans Sukhtankar, Priya Williams, Nicola C. Ockenhouse, Christian F. Kathcart, April K. Qabar, Aziz N. Waters, Norman C. Soisson, Lorraine A. Birkett, Ashley J. Cooke, Graham S. Faust, Saul N. Woods, Colleen Ivinson, Karen McCarthy, James S. Diggs, Carter L. Vekemans, Johan Long, Carole A. Hill, Adrian V. S. Lawrie, Alison M. Dutta, Sheetij Draper, Simon J. TI Demonstration of the Blood-Stage Plasmodium falciparum Controlled Human Malaria Infection Model to Assess Efficacy of the P. falciparum Apical Membrane Antigen 1 Vaccine, FMP2.1/AS01 SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE malaria; AMA1; vaccine; blood stage; CHMI ID PARASITE MULTIPLICATION RATES; RANDOMIZED CONTROLLED-TRIAL; CLINICAL-TRIAL; IMMUNOGENICITY; ANTIBODY; SAFETY; SPOROZOITES; VOLUNTEERS; CHALLENGE; PROTEIN AB Background. Models of controlled human malaria infection (CHMI) initiated by mosquito bite have been widely used to assess efficacy of preerythrocytic vaccine candidates in small proof-of-concept phase 2a clinical trials. Efficacy testing of blood-stage malaria parasite vaccines, however, has generally relied on larger-scale phase 2b field trials in malaria-endemic populations. We report the use of a blood-stage P. falciparum CHMI model to assess blood-stage vaccine candidates, using their impact on the parasite multiplication rate (PMR) as the primary efficacy end point. Methods. Fifteen healthy United Kingdom adult volunteers were vaccinated with FMP2.1, a protein vaccine that is based on the 3D7 clone sequence of apical membrane antigen 1 (AMA1) and formulated in Adjuvant System 01 (AS01). Twelve vaccinees and 15 infectivity controls subsequently underwent blood-stage CHMI. Parasitemia was monitored by quantitative real-time polymerase chain reaction (PCR) analysis, and PMR was modeled from these data. Results. FMP2.1/AS01 elicited anti-AMA1 T-cell and serum antibody responses. Analysis of purified immunoglobulin G showed functional growth inhibitory activity against P. falciparum in vitro. There were no vaccine-or CHMI-related safety concerns. All volunteers developed blood-stage parasitemia, with no impact of the vaccine on PMR. Conclusions. FMP2.1/AS01 demonstrated no efficacy after blood-stage CHMI. However, the model induced highly reproducible infection in all volunteers and will accelerate proof-of-concept testing of future blood-stage vaccine candidates. C1 [Payne, Ruth O.; Milne, Kathryn H.; Elias, Sean C.; Edwards, Nick J.; Douglas, Alexander D.; Brown, Rebecca E.; Silk, Sarah E.; Biswas, Sumi; Rampling, Thomas W.; Venkatraman, Navin; Hodgson, Susanne H.; Labbe, Genevieve M.; Halstead, Fenella D.; Nugent, Fay L.; Hill, Adrian V. S.; Draper, Simon J.] Univ Oxford, Jenner Inst Labs, Oxford OX1 2JD, England. [Payne, Ruth O.; Roberts, Rachel; Rampling, Thomas W.; Venkatraman, Navin; Hodgson, Susanne H.; Poulton, Ian D.; Lawrie, Alison M.] Univ Oxford, Ctr Clin Vaccinol & Trop Med, Oxford OX1 2JD, England. [Williams, Nicola C.] Univ Oxford, Ctr Stat Med, Oxford OX1 2JD, England. [Williams, Nicola C.] Univ Oxford, Botnar Res Ctr, Oxford OX1 2JD, England. [de Graaf, Hans; Sukhtankar, Priya; Faust, Saul N.] Univ Hosp Southampton Natl Hlth Serv NHS Fdn Trus, Natl Inst Hlth Res NIHR Wellcome Trust Clin Res F, Southampton, Hants, England. [de Graaf, Hans; Sukhtankar, Priya; Faust, Saul N.] Univ Southampton, Fac Med, Southampton SO9 5NH, Hants, England. [Cooke, Graham S.] Imperial Coll Healthcare NHS Trust, NIHR Wellcome Trust Clin Res Facil, London, England. [Miura, Kazutoyo; Long, Carole A.] NIAID, Lab Malaria & Vector Res, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA. [Ockenhouse, Christian F.; Kathcart, April K.; Qabar, Aziz N.; Waters, Norman C.; Dutta, Sheetij] Walter Reed Army Inst Res, Mil Malaria Res Program, Silver Spring, MD USA. [Ockenhouse, Christian F.; Birkett, Ashley J.; Woods, Colleen; Ivinson, Karen] PATH Malaria Vaccine Initiat, Washington, DC USA. [Soisson, Lorraine A.; Diggs, Carter L.] US Agcy Int Dev, Washington, DC 20523 USA. [McCarthy, James S.] QIMR Berghofer Med Res Inst, Herston, Qld, Australia. [Vekemans, Johan] GlaxoSmithKline Vaccines, Rixensart, Belgium. RP Payne, RO (reprint author), Churchill Hosp, CCVTM, Old Rd, Oxford OX3 7LE, England. EM ruth.payne@ndm.ox.ac.uk FU PATH Malaria Vaccine Initiative (MVI), through the Infectious Disease Division, Bureau for Global Health, US Agency for International Development [GHS-A-00-04-00016-00]; National Institute of Allergy and Infectious Diseases, National Institutes of Health; United Kingdom National Institute of Health Research (NIHR) infrastructure, through the NIHR Oxford Biomedical Research Centre; United Kingdom National Institute of Health Research (NIHR) infrastructure, through Southampton NIHR Wellcome Trust Clinical Research Facility; United Kingdom National Institute of Health Research (NIHR) infrastructure, through Imperial College NIHR Wellcome Trust Clinical Research Facility; Wellcome Trust [089455/2/09/Z, 097940/Z/11/Z]; St Catherine's College, Oxford University; Nuffield Department of Medicine; Jenner Institute; Lister Institute; United Kingdom Medical Research Council (MRC); Department for International Development (DFID); EDCTP2 program; European Union (MRC) [G1000527] FX This work was supported by the PATH Malaria Vaccine Initiative (MVI), through the Infectious Disease Division, Bureau for Global Health, US Agency for International Development (under cooperative agreement GHS-A-00-04-00016-00); by the Intramural Program of the National Institute of Allergy and Infectious Diseases, National Institutes of Health; by the United Kingdom National Institute of Health Research (NIHR) infrastructure, through the NIHR Oxford Biomedical Research Centre, the Southampton NIHR Wellcome Trust Clinical Research Facility, and the Imperial College NIHR Wellcome Trust Clinical Research Facility; by the Wellcome Trust (research training fellowships 089455/2/09/Z [to A. D. D.] and 097940/Z/11/Z [to S. H. H.]); by St Catherine's College, Oxford University (junior research fellowship to S. B.) and Nuffield Department of Medicine leadership fellowship (to S. B.); by the Jenner Institute (Jenner Investigator appointments to A. V. S. H. and S. J. D.); by the Lister Institute (research prize fellowship to S. J. D.); and, jointly, by the United Kingdom Medical Research Council (MRC) and Department for International Development (DFID), under the MRC/DFID Concordat agreement, and by the EDCTP2 program, supported by the European Union (MRC career development fellowship G1000527 to S. J. D.). NR 44 TC 7 Z9 7 U1 2 U2 2 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD JUN 1 PY 2016 VL 213 IS 11 BP 1743 EP 1751 DI 10.1093/infdis/jiw039 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA DO0BC UT WOS:000377443400011 PM 26908756 ER PT J AU Troha, T Rigler, M Alden, D Bryan, I Guo, W Kirste, R Mita, S Gerhold, MD Collazo, R Sitar, Z Zgonik, M AF Troha, T. Rigler, M. Alden, D. Bryan, I. Guo, W. Kirste, R. Mita, S. Gerhold, M. D. Collazo, R. Sitar, Z. Zgonik, M. TI UV second harmonic generation in AlN waveguides with modal phase matching SO OPTICAL MATERIALS EXPRESS LA English DT Article ID LASER-DIODE; THIN-FILMS; LIGHT; BLUE; AIN; GAN AB AlN waveguides on sapphire substrates were fabricated from AlN films grown by metalorganic chemical vapor deposition. By tuning the wavelength of the pump light we demonstrated a second harmonic generation in the UV at 306, 331, and 356 nm using the d(33) coefficient and modal dispersion phase matching (MDPM). A theoretical model for MDPM with two-and three-mode interaction in planar waveguides was used to explain the results. Its essential component describes the interaction of two, possibly different, waveguide modes at the fundamental frequency that excite the third mode at doubled frequency. The experimental results were found to agree well with the theoretical model. This work confirmed the application potential of high-quality AlN films as waveguides for nonlinear processes. (C) 2016 Optical Society of America C1 [Troha, T.; Rigler, M.; Zgonik, M.] Univ Ljubljana, Fac Math & Phys, Jadranska 19, Ljubljana 1000, Slovenia. [Alden, D.; Bryan, I.; Guo, W.; Sitar, Z.] N Carolina State Univ, Dept Mat Sci & Engn, 1001 Capability Dr Raleigh, Raleigh, NC 27606 USA. [Kirste, R.; Mita, S.; Collazo, R.] Adroit Mat, 2054 Kildaire Farm Rd,Suite 205, Cary, NC 27518 USA. [Gerhold, M. D.] Engn Sci Directorate, Army Res Off, POB 12211, Res Triangle Pk, NC 27703 USA. [Zgonik, M.] Jozef Stefan Inst, Jamova 39, Ljubljana 1000, Slovenia. RP Troha, T (reprint author), Univ Ljubljana, Fac Math & Phys, Jadranska 19, Ljubljana 1000, Slovenia. EM tinkara.troha@fmf.uni-lj.si FU NSF [DMR-1108071, DMR-1312582, ECCS-1508854, DMR-1508191]; ARO [W911NF-15-2-0068, W911NF-14-C-0008]; ARRS [N1-0021] FX Partial financial support from NSF (DMR-1108071, DMR-1312582, ECCS-1508854, DMR-1508191), ARO (W911NF-15-2-0068, W911NF-14-C-0008), and ARRS (N1-0021) is greatly appreciated. NR 22 TC 1 Z9 1 U1 6 U2 8 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 2159-3930 J9 OPT MATER EXPRESS JI Opt. Mater. Express PD JUN 1 PY 2016 VL 6 IS 6 BP 2014 EP 2023 PG 10 WC Materials Science, Multidisciplinary; Optics SC Materials Science; Optics GA DO0ZG UT WOS:000377507100024 ER PT J AU Bastian, ND Griffin, PM Spero, E Fulton, LV AF Bastian, Nathaniel D. Griffin, Paul M. Spero, Eric Fulton, Lawrence V. TI Multi-criteria logistics modeling for military humanitarian assistance and disaster relief aerial delivery operations SO OPTIMIZATION LETTERS LA English DT Article DE Multiple criteria decision analysis; Stochastic optimization; Facility location; Humanitarian logistics; Supply chain engineering; Aerial delivery operations ID OPTIMIZATION AB Given that it is not always feasible to reach an affected area via land or sea within the first week following a natural disaster, aerial delivery provides the primary means to rapidly supply the affected population. Further, it is often the case that high density delivery of humanitarian aid supplies are taken over by non-friendly groups within the affected population. By using direct airdrop systems to deliver large quantities of individually wrapped food and water items, dispersion among the affected disaster relief population will occur more quickly. In this paper, we proffer a multiple criteria decision analysis (MCDA) framework to optimize the military humanitarian assistance/disaster relief (HA/DR) aerial delivery supply chain network. The model uses stochastic, mixed-integer, weighted goal programming to optimize network design, logistics costs, staging locations, procurement amounts, and inventory levels. The MCDA framework enables decision-makers to explore the trade-offs between military HA/DR aerial delivery supply chain efficiency and responsiveness, while optimizing across a wide range of real-world, probabilistic scenarios to account for the inherent uncertainty in the location of global humanitarian disasters as well as the amount of demand to be met. C1 [Bastian, Nathaniel D.] Penn State Univ, Dept Ind & Mfg Engn, 355 Leonhard Bldg, University Pk, PA 16802 USA. [Griffin, Paul M.] Georgia Inst Technol, Sch Ind & Syst Engn, 755 Ferst Dr, Atlanta, GA 30332 USA. [Spero, Eric] US Army, Res Lab, Vehicle Appl Res Div, 4603 Flare Loop, Aberdeen, MD 21005 USA. [Fulton, Lawrence V.] Texas Tech Univ, Rawls Coll Business Adm, 703 Flint Ave, Lubbock, TX 79410 USA. RP Bastian, ND (reprint author), Penn State Univ, Dept Ind & Mfg Engn, 355 Leonhard Bldg, University Pk, PA 16802 USA. EM ndbastian@psu.edu; pgriffin@gatech.edu; eric.spero.civ@mail.mil; larry.fulton@ttu.edu FU U.S. Army Research Laboratory; U.S. Army Natick Soldier Research Development and Engineering Center; National Science Foundation [DGE1255832] FX This work is partially supported by the U.S. Army Research Laboratory and the U.S. Army Natick Soldier Research Development and Engineering Center. The first author was supported in part by the National Science Foundation under Grant No. DGE1255832. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the United States Army, National Science Foundation, Pennsylvania State University, Georgia Institute of Technology, or Texas Tech University. NR 38 TC 2 Z9 2 U1 8 U2 11 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1862-4472 EI 1862-4480 J9 OPTIM LETT JI Optim. Lett. PD JUN PY 2016 VL 10 IS 5 SI SI BP 921 EP 953 DI 10.1007/s11590-015-0888-1 PG 33 WC Operations Research & Management Science; Mathematics, Applied SC Operations Research & Management Science; Mathematics GA DN9XV UT WOS:000377434900004 ER PT J AU Paech, GM Banks, S Pajcin, M Grant, C Johnson, K Kamimori, GH Della Vedova, CB AF Paech, Gemma M. Banks, Siobhan Pajcin, Maja Grant, Crystal Johnson, Kayla Kamimori, Gary H. Della Vedova, Chris B. TI Caffeine administration at night during extended wakefulness effectively mitigates performance impairment but not subjective assessments of fatigue and sleepiness SO PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR LA English DT Article DE Sleep loss; Extended wakefulness; Stimulants; Caffeine; Karolinska Sleepiness Scale; Psychomotor vigilance task ID NEUROBEHAVIORAL FUNCTION; COGNITIVE PERFORMANCE; MEDICAL ERRORS; DEPRIVATION; MOOD; PSYCHOMOTOR; RESTRICTION; MODAFINIL; ALERTNESS; VIGILANCE AB The current study investigated the effects of repeated caffeine administration on performance and subjective reports of sleepiness and fatigue during 50 h extended wakefulness. Twenty-four, non-smokers aged 22.5 +/- 2.9 y (mean +/- SD) remained awake for two nights (50 h) in a controlled laboratory environment. During this period, 200 mg of caffeine or placebo gum was administered at 01:00, 03:00, 05:00 and 07:00 on both nights (total of 800 mg/night). Neurobehavioral performance and subjective reports were assessed throughout the wake period. Caffeine improved performance compared to placebo, but did not affect overall ratings of subjective sleepiness and fatigue. Performance and sleepiness worsened with increasing time awake for both conditions. However, caffeine slowed performance impairments such that after 50 h of wakefulness performance was better following caffeine administration compared to placebo. Caffeine also slowed the increase in subjective sleepiness and performance ratings, but only during the first night of wakefulness. After two nights of sleep deprivation, there was no difference in sleepiness ratings between the two conditions. These results demonstrate that strategic administration of caffeine effectively mitigates performance impairments associated with 50 h wakefulness but does not improve overall subjective assessments of sleepiness, fatigue and performance. Results indicate that while performance impairment is alleviated, individuals may continue to report feelings of sleepiness. Individuals who use caffeine as a countermeasure in sustained operations may feel as though caffeine is not effective despite impairments in objective performance being largely mitigated. (C) 2016 Elsevier Inc. All rights reserved. C1 [Paech, Gemma M.; Banks, Siobhan; Grant, Crystal] Univ S Australia, Ctr Sleep Res, Adelaide, SA 5001, Australia. [Paech, Gemma M.] Washington State Univ, Sleep & Performance Res Ctr, Spokane, WA USA. [Paech, Gemma M.] Washington State Univ, Elson S Floyd Coll Med, Spokane, WA USA. [Pajcin, Maja; Della Vedova, Chris B.] Univ S Australia, Sch Pharm & Med Sci, Adelaide, SA 5001, Australia. [Johnson, Kayla] Dept Def, Def Sci & Technol Grp, Edinburgh, Australia. [Kamimori, Gary H.] Walter Reed Army Inst Res, Behav Biol Branch, Silver Spring, MD USA. RP Paech, GM (reprint author), Sleep & Performance Res Ctr, POB 1495, Spokane, WA 99210 USA. EM gemma.paech@wsu.edu RI Banks, Siobhan/L-2149-2013; OI Banks, Siobhan/0000-0002-7489-0929; Della Vedova, Chris/0000-0002-2361-3729 FU Defence Science and Technology Organisation, Australian Government, Department of Defence; US Army Medical Research and Material Command; ONR [N00014-15-1-0019] FX The authors thank participants and staff who helped with data collection, in particular Katja Morsky, Charitha Sayakkarage, Megan Dittman and Dong Jae Ryoo. We would also like to acknowledge Professor Gary Wittert, Glen Pierce, Philip Jacques, Justin Fidock and Stephanie Eonta. This work was supported by the Defence Science and Technology Organisation, Australian Government, Department of Defence. This work was also supported by the US Army Medical Research and Material Command. This material has been reviewed by the Walter Reed Army Institute of Research, and there is no objection to its presentation and/or publication. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the position of the Department of the Army of the Department of Defence. Dr Paech was supported in part by ONR grant N00014-15-1-0019 to Washington State University (PI: D.A. Grant). The authors have no conflicts of interest to report. NR 39 TC 0 Z9 0 U1 8 U2 9 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0091-3057 J9 PHARMACOL BIOCHEM BE JI Pharmacol. Biochem. Behav. PD JUN PY 2016 VL 145 BP 27 EP 32 DI 10.1016/j.pbb.2016.03.011 PG 6 WC Behavioral Sciences; Neurosciences; Pharmacology & Pharmacy SC Behavioral Sciences; Neurosciences & Neurology; Pharmacology & Pharmacy GA DN8JZ UT WOS:000377326300005 PM 27061779 ER PT J AU Perliger, A Pedahzur, A AF Perliger, Arie Pedahzur, Ami TI Counter Cultures, Group Dynamics and Religious Terrorism SO POLITICAL STUDIES LA English DT Article DE counter cultures; group dynamics; religious; terrorism ID BRANCH DAVIDIANS; IDENTITY FUSION; CENTRALITY; CONFLICT; NETWORKS; ACTIVISM AB Totalistic ideologies are breeding grounds for radicalization. Communities that adhere to such ideologies tend to rally when they feel threatened by powerful outsiders. Under such circumstances, community leaders become central. If they frame the situation as an existential threat to the community itself or to its most sacred values, they will accelerate the radicalization process and subsequently increase the prospects of violent actions by group members. The shift to violence takes place in the framework of close-knit social networks within the broader radicalized community. These networks consist of individuals who usually live in the same area and engage in continuous interaction among themselves. Such interactions bolster their communal commitment and develop a collective mindset that facilitates the slide of some of the individuals into violence. Those who eventually descend into terrorism usually exhibit strong identification with the community's values and extreme alienation towards the outside world. They also enjoy high levels of biographical availability. These hypotheses are tested using the case study of Jewish terrorism in Israel between 1948 and 2006. C1 [Perliger, Arie] US Mil Acad, 607 Cullum Rd,Lincoln Hall,Rm 122, West Point, NY 10996 USA. [Pedahzur, Ami] Univ Texas Austin, Dept Govt, Mailcode A1800, Austin, TX 78712 USA. RP Perliger, A (reprint author), US Mil Acad, 607 Cullum Rd,Lincoln Hall,Rm 122, West Point, NY 10996 USA. EM aperliger@gmail.com; pedahzur@austin.utexas.edu NR 81 TC 0 Z9 0 U1 8 U2 14 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0032-3217 EI 1467-9248 J9 POLIT STUD-LONDON JI Polit. Stud. PD JUN PY 2016 VL 64 IS 2 BP 297 EP 314 DI 10.1111/1467-9248.12182 PG 18 WC Political Science SC Government & Law GA DN8RK UT WOS:000377346900003 ER PT J AU Convertino, VA Wirt, MD Glenn, JF Lein, BC AF Convertino, Victor A. Wirt, Michael D. Glenn, John F. Lein, Brian C. TI THE COMPENSATORY RESERVE FOR EARLY AND ACCURATE PREDICTION OF HEMODYNAMIC COMPROMISE: A REVIEW OF THE UNDERLYING PHYSIOLOGY SO SHOCK LA English DT Review DE Hemorrhage; lower body negative pressure; shock; trauma; vital signs ID BODY NEGATIVE-PRESSURE; GENOME-WIDE ASSOCIATION; TRADITIONAL VITAL SIGNS; GOAL-DIRECTED THERAPY; SHOCK INDEX; CENTRAL HYPOVOLEMIA; BLOOD-LOSS; TRAUMA PATIENTS; CARDIAC-OUTPUT; SEPTIC SHOCK AB Shock is deadly and unpredictable if it is not recognized and treated in early stages of hemorrhage. Unfortunately, measurements of standard vital signs that are displayed on current medical monitors fail to provide accurate or early indicators of shock because of physiological mechanisms that effectively compensate for blood loss. As a result of new insights provided by the latest research on the physiology of shock using human experimental models of controlled hemorrhage, it is now recognized that measurement of the body's reserve to compensate for reduced circulating blood volume is the single most important indicator for early and accurate assessment of shock. We have called this function the "compensatory reserve," which can be accurately assessed by real-time measurements of changes in the features of the arterial waveform. In this paper, the physiology underlying the development and evaluation of a new noninvasive technology that allows for real-time measurement of the compensatory reserve will be reviewed, with its clinical implications for earlier and more accurate prediction of shock. C1 [Convertino, Victor A.; Wirt, Michael D.] US Army Inst Surg Res, 3698 Chambers Pass,Bldg 3611, Ft Sam Houston, TX 78234 USA. [Glenn, John F.; Lein, Brian C.] US Army Med Res & Mat Command, Ft Detrick, MD USA. RP Convertino, VA (reprint author), US Army Inst Surg Res, 3698 Chambers Pass,Bldg 3611, Ft Sam Houston, TX 78234 USA. EM victor.a.convertino.civ@mail.mil NR 77 TC 5 Z9 5 U1 5 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2016 VL 45 IS 6 BP 580 EP 590 DI 10.1097/SHK.0000000000000559 PG 11 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA DO3OB UT WOS:000377689800002 PM 26950588 ER PT J AU Desai, SB Madhvapathy, SR Amani, M Kiriya, D Hettick, M Tosun, M Zhou, YZ Dubey, M Ager, JW Chrzan, D Javey, A AF Desai, Sujay B. Madhvapathy, Surabhi R. Amani, Matin Kiriya, Daisuke Hettick, Mark Tosun, Mahmut Zhou, Yuzhi Dubey, Madan Ager, Joel W., III Chrzan, Daryl Javey, Ali TI Gold-Mediated Exfoliation of Ultralarge Optoelectronically-Perfect Monolayers SO ADVANCED MATERIALS LA English DT Article ID TRANSITION-METAL DICHALCOGENIDES; FIELD-EFFECT TRANSISTORS; LARGE-AREA; 2-DIMENSIONAL MATERIALS; MOS2; GRAPHENE; LAYERS; WSE2; INTERFACE; FILMS AB Gold-mediated exfoliation of ultralarge optoelectronically perfect monolayers with lateral dimensions up to approximate to 500 mu m is reported. Electrical, optical, and X-ray photo electron spectroscopy characterization show that the quality of the gold-exfoliated flakes is similar to that of tape-exfoliated flakes. Large-area flakes allow manufacturing of large-area monolayer transition metal dichalcogenide electronics. C1 [Desai, Sujay B.; Madhvapathy, Surabhi R.; Amani, Matin; Kiriya, Daisuke; Hettick, Mark; Tosun, Mahmut; Javey, Ali] Univ Calif Berkeley, Elect Engn & Comp Sci, Berkeley, CA 94720 USA. [Desai, Sujay B.; Madhvapathy, Surabhi R.; Amani, Matin; Kiriya, Daisuke; Hettick, Mark; Tosun, Mahmut; Ager, Joel W., III; Chrzan, Daryl; Javey, Ali] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Mat Sci, Berkeley, CA 94720 USA. [Desai, Sujay B.; Amani, Matin; Kiriya, Daisuke; Hettick, Mark; Tosun, Mahmut; Javey, Ali] Univ Calif Berkeley, Berkeley Sensor & Actuator Ctr, Berkeley, CA 94720 USA. [Zhou, Yuzhi; Ager, Joel W., III; Chrzan, Daryl] Univ Calif Berkeley, Mat Sci & Engn Dept, Berkeley, CA 94720 USA. [Dubey, Madan] US Army, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20723 USA. RP Javey, A (reprint author), Univ Calif Berkeley, Elect Engn & Comp Sci, Berkeley, CA 94720 USA.; Javey, A (reprint author), Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Mat Sci, Berkeley, CA 94720 USA.; Javey, A (reprint author), Univ Calif Berkeley, Berkeley Sensor & Actuator Ctr, Berkeley, CA 94720 USA. EM ajavey@eecs.berkeley.edu FU Electronics Materials program - Office of Science, Office of Basic Energy Sciences, Material Sciences and Engineering Division of the U.S. Department of Energy [DE-AC02-05CH11231]; Office of Science of the U.S. Department of Energy [DE-SC0004993] FX S.B.D., S.R.M., and M.A. contributed equally to this work. This work was supported by the Electronics Materials program funded by the Director, Office of Science, Office of Basic Energy Sciences, Material Sciences and Engineering Division of the U.S. Department of Energy under Contract No. DE-AC02-05CH11231. XPS measurements were performed at the Joint Center for Artificial Photosynthesis (JCAP), a Department of Energy (DOE) Energy Innovation Hub, supported through the Office of Science of the U.S. Department of Energy under Award No. DE-SC0004993 NR 28 TC 2 Z9 2 U1 20 U2 42 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 0935-9648 EI 1521-4095 J9 ADV MATER JI Adv. Mater. PD JUN 1 PY 2016 VL 28 IS 21 BP 4053 EP 4058 DI 10.1002/adma.201506171 PG 6 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA DN5PK UT WOS:000377122400008 PM 27007751 ER PT J AU Lanier, JB Bury, DC Richardson, SW AF Lanier, Jeffrey B. Bury, David C. Richardson, Sean W. TI Diet and Physical Activity for Cardiovascular Disease Prevention SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID FORCE RECOMMENDATION STATEMENT; LONG-CHAIN OMEGA-3-FATTY-ACIDS; MEDITERRANEAN DIET; HEALTHFUL DIET; UNITED-STATES; SODIUM-INTAKE; FAT DIETS; METAANALYSIS; RISK; ADULTS AB Cardiovascular disease (CVD) is the leading cause of death in the United States. One-third of these deaths may be preventable through healthy lifestyle choices including diet and physical activity. The Mediterranean diet is associated with reduced cardiovascular mortality, whereas the Dietary Approaches to Stop Hypertension (DASH) eating plan is associated with a reduced risk of coronary artery disease. Substituting dietary saturated fat with polyunsaturated fatty acids is associated with improved cardiovascular outcomes, although exogenous supplementation with omega-3 fatty acids does not improve cardiovascular outcomes. There is an association between increased sodium intake and cardiovascular risk, but reducing dietary sodium has not consistently shown a reduction in cardiovascular risk. Physical activity recommendations for adults are at least 150 minutes of moderate-intensity aerobic activity per week, 75 minutes of vigorous-intensity aerobic activity per week, or an equivalent combination. Increases in physical activity by any level are associated with reduced cardiovascular risk. Introducing muscle-strengthening activities at least twice per week in previously inactive adults is associated with improved cardiovascular outcomes. Inactive adults without known CVD can gradually increase activity to a moderate-intensity level without consulting a physician. The U.S. Preventive Services Task Force recommends behavioral counseling to promote healthy diet and physical activity in adults at high risk of CVD. Evidence of benefit for counseling patients at average risk is less established. Copyright (C) 2016 American Academy of Family Physicians. C1 [Lanier, Jeffrey B.] US Army, Recruiting Command, Ft Knox, KY USA. [Bury, David C.] US Army, Hlth Clin, Camp Casey, South Korea. [Richardson, Sean W.] Martin Army Community Hosp, Family Med Residency Program, Ft Benning, GA USA. RP Lanier, JB (reprint author), US Army Med Recruiting Brigade, 1889 Old Ironsides Ave, Ft Knox, KY 40121 USA. EM jeffrey.b.lanier.mil@mail.mil NR 34 TC 1 Z9 1 U1 8 U2 14 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X EI 1532-0650 J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD JUN 1 PY 2016 VL 93 IS 11 BP 919 EP 924 PG 6 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA DN1LE UT WOS:000376826500005 PM 27281836 ER PT J AU Hinojosa-Laborde, C Howard, JT Mulligan, J Grudic, GZ Convertino, VA AF Hinojosa-Laborde, Carmen Howard, Jeffrey T. Mulligan, Jane Grudic, Greg Z. Convertino, Victor A. TI Comparison of compensatory reserve during lower-body negative pressure and hemorrhage in nonhuman primates SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY LA English DT Article DE blood loss; central hypovolemia; stroke volume; blood pressure; compensatory mechanisms ID COMBAT CASUALTY CARE; BLOOD-LOSS; CENTRAL HYPOVOLEMIA; CARDIAC-OUTPUT; STROKE VOLUME; TOLERANCE; PROGRESSION; RESPONSES; HUMANS; DEATH AB Compensatory reserve was measured in baboons (n = 13) during hemorrhage (Hem) and lower-body negative pressure (LBNP) using a machine-learning algorithm developed to estimate compensatory reserve by detecting reductions in central blood volume during LBNP. The algorithm calculates compensatory reserve index (CRI) from normovolemia (CRI = 1) to cardiovascular decompensation (CRI = 0). The hypothesis was that Hem and LBNP will elicit similar CRI values and that CRI would have higher specificity than stroke volume (SV) in predicting decompensation. Blood was removed in four steps: 6.25%, 12.5%, 18.75%, and 25% of total blood volume. Four weeks after Hem, the same animals were subjected to four levels of LBNP that was matched on the basis of their central venous pressure. Data (mean +/- 95% confidence interval) indicate that CRI decreased (P < 0.001) from baseline during Hem (0.69 +/- 0.10, 0.57 +/- 0.09, 0.36 +/- 0.10, 0.16 +/- 0.08, and 0.08 +/- 0.03) and LBNP (0.76 +/- 0.05, 0.66 +/- 0.08, 0.36 +/- 0.13, 0.23 +/- 0.11, and 0.14 +/- 0.09). CRI was not different between Hem and LBNP (P = 0.20). Linear regression analysis between Hem CRI and LBNP CRI revealed a slope of 1.03 and a correlation coefficient of 0.96. CRI exhibited greater specificity than SV in both Hem (92.3 vs. 82.1) and LBNP (94.8 vs. 83.1) and greater ROC AUC in Hem (0.94 vs. 0.84) and LBNP (0.94 vs. 0.92). These data support the hypothesis that Hem and LBNP elicited the same CRI response, suggesting that measurement of compensatory reserve is superior to SV as a predictor of cardiovascular decompensation C1 [Hinojosa-Laborde, Carmen; Howard, Jeffrey T.; Convertino, Victor A.] US Army, Inst Surg Res, Joint Base San Antonio F, TX USA. [Mulligan, Jane; Grudic, Greg Z.] Flashback Technol, Boulder, CO USA. RP Hinojosa-Laborde, C (reprint author), US Army, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM carmen.hinojosa-laborde.civ@mail.mil FU U.S. Army Medical Research and Materiel Command Combat Casualty Care Research Program; Oak Ridge Institute of Science and Education FX This research was supported by funding from the U.S. Army Medical Research and Materiel Command Combat Casualty Care Research Program and in part by a postdoctoral fellowship provided by the Oak Ridge Institute of Science and Education. We thank Gary Muniz from U.S. Army Institute of Surgical Research; and Dr. Robert E. Shade and Dr. Cassondra Bauer from the Texas Biomedical Research Institute for their technical contributions to this study. NR 29 TC 0 Z9 0 U1 1 U2 3 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0363-6119 EI 1522-1490 J9 AM J PHYSIOL-REG I JI Am. J. Physiol.-Regul. Integr. Comp. Physiol. PD JUN 1 PY 2016 VL 310 IS 11 BP R1154 EP R1159 DI 10.1152/ajpregu.00304.2015 PG 6 WC Physiology SC Physiology GA DN4GK UT WOS:000377021700016 PM 27030667 ER PT J AU Reiter, MJ Schwope, RB Theler, JM AF Reiter, Michael J. Schwope, Ryan B. Theler, Jared M. TI Postoperative CT of the Orbital Skeleton After Trauma: Review of Normal Appearances and Common Complications SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Review DE orbital fracture; postsurgical orbit; zygomaticomaxillary complex fracture ID COMPUTED-TOMOGRAPHY; FLOOR FRACTURES; MAXILLOFACIAL TRAUMA; MIDFACE FRACTURES; WALL FRACTURES; SURGEON NEEDS; RECONSTRUCTION; MANAGEMENT; REPAIR; RADIOGRAPHS AB OBJECTIVE. The purpose of this article is to describe both the expected and unexpected imaging features of posttraumatic defects of the orbital skeleton after surgical repair. CONCLUSION. The goal of surgery is to restore the preinjury orbital anatomy to improve function and prevent enophthalmos. Radiologists need to be cognizant of the more frequently encountered operative procedures used for orbital fracture repair, the desired goals of treatment, and common complications. This will permit accurate interpretation of postoperative CT and provide surgeons with clinically useful results. C1 [Reiter, Michael J.] SUNY Stony Brook, Med Ctr, Dept Radiol, HSC Level 4,Rm 120,East Loop Rd, Stony Brook, NY 11794 USA. [Schwope, Ryan B.] Brooke Army Med Ctr, Dept Radiol, San Antonio, TX USA. [Schwope, Ryan B.] Uniformed Serv Univ Hlth Sci, Dept Radiol, Bethesda, MD 20814 USA. [Theler, Jared M.] Brooke Army Med Ctr, Dept Otolaryngol, San Antonio, TX USA. RP Reiter, MJ (reprint author), SUNY Stony Brook, Med Ctr, Dept Radiol, HSC Level 4,Rm 120,East Loop Rd, Stony Brook, NY 11794 USA. EM mikereiter13@yahoo.com NR 45 TC 0 Z9 0 U1 2 U2 2 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X EI 1546-3141 J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD JUN PY 2016 VL 206 IS 6 BP 1276 EP 1285 DI 10.2214/AJR.15.15477 PG 10 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA DN2XW UT WOS:000376927300030 PM 27010378 ER PT J AU Garcia-Reyero, N AF Garcia-Reyero, Natalia TI Advancing Ecotoxicology in the US Southern States SO BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY LA English DT Editorial Material C1 [Garcia-Reyero, Natalia] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA. [Garcia-Reyero, Natalia] Mississippi State Univ, IGBB, Starkville, MS USA. RP Garcia-Reyero, N (reprint author), US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA.; Garcia-Reyero, N (reprint author), Mississippi State Univ, IGBB, Starkville, MS USA. EM Natalia.G.Vinas@erdc.dren.mil NR 0 TC 1 Z9 1 U1 1 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0007-4861 EI 1432-0800 J9 B ENVIRON CONTAM TOX JI Bull. Environ. Contam. Toxicol. PD JUN PY 2016 VL 96 IS 6 BP 705 EP 706 DI 10.1007/s00128-016-1824-5 PG 2 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA DN3SR UT WOS:000376984200001 PM 27209542 ER PT J AU Garcia-Reyero, N Escalon, L Prats, E Faria, M Soares, AMVM Raldua, D AF Garcia-Reyero, Natalia Escalon, Lynn Prats, Eva Faria, Melissa Soares, Amadeu M. V. M. Raldua, Demetrio TI Targeted Gene Expression in Zebrafish Exposed to Chlorpyrifos-Oxon Confirms Phenotype-Specific Mechanisms Leading to Adverse Outcomes SO BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY LA English DT Article DE Zebrafish; Gene expression; Oxidative stress; Mitochondria; Chlorpyrifos-oxon ID OXIDATIVE STRESS; CELL-DEATH; CALCIUM; PESTICIDE; MITOCHONDRIA AB Zebrafish models for mild, moderate, and severe acute organophosphorus poisoning were previously developed by exposing zebrafish larvae to chlopyrifos-oxon. The phenotype of these models was characterized at several levels of biological organization. Oxidative stress and mitochondrial dysfunction were found to be involved in the development of the more severe phenotype. Here we used targeted gene expression to understand the dose-responsiveness of those two pathways and their involvement on generating the different zebrafish models. As the severe phenotype is irreversible after only 3 h of exposure, we also analyzed the response of the oxidative stress pathway at 3 and 24 h. Some of the genes related to oxidative stress were already differentially expressed at 3 h. There was an increase in differentially expressed genes related to both oxidative stress and mitochondrial function from the more mild to the more severe phenotype, suggesting the involvement of these mechanisms in increasing phenotype severity. Temporal data suggest that peroxynitrite leading to lipid peroxidation might be involved in phenotype transition and irreversibility. C1 [Garcia-Reyero, Natalia; Escalon, Lynn] US Army Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. [Garcia-Reyero, Natalia] Mississippi State Univ, Inst Genom Biocomp & Biotechnol, 2 Res Blvd, Starkville, MS 39759 USA. [Prats, Eva] CSIC, CIC, Jordi Girona 18, ES-08034 Barcelona, Spain. [Faria, Melissa; Soares, Amadeu M. V. M.] Univ Aveiro, Dept Biol, P-3800 Aveiro, Portugal. [Faria, Melissa; Soares, Amadeu M. V. M.] Univ Aveiro, CESAM, P-3800 Aveiro, Portugal. [Faria, Melissa; Raldua, Demetrio] CSIC, IDAEA, Jordi Girona 18, ES-08034 Barcelona, Spain. RP Garcia-Reyero, N (reprint author), US Army Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.; Garcia-Reyero, N (reprint author), Mississippi State Univ, Inst Genom Biocomp & Biotechnol, 2 Res Blvd, Starkville, MS 39759 USA. EM natalia.g.vinas@erdc.dren.mil RI CESAM, UA/M-3762-2015; Soares, Amadeu/A-8304-2008; OI Soares, Amadeu/0000-0003-0879-9470; Raldua, Demetrio/0000-0001-5256-1641 FU US Army ERDC-IRO [W912HZ-13-BAA-01]; Environmental Quality Research Program; NATO SfP project [MD.SFPP 984777]; National Science Foundation EPSCoR Grant [EPS-0903787] FX This work was supported in part by the US Army ERDC-IRO (W912HZ-13-BAA-01; D.R., N.G.R.) and Environmental Quality Research Program (N.G.R.), the NATO SfP project MD.SFPP 984777 (D.R., N.G.R.), and the National Science Foundation EPSCoR Grant EPS-0903787 (N.G.R.). NR 21 TC 0 Z9 0 U1 4 U2 7 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0007-4861 EI 1432-0800 J9 B ENVIRON CONTAM TOX JI Bull. Environ. Contam. Toxicol. PD JUN PY 2016 VL 96 IS 6 BP 707 EP 713 DI 10.1007/s00128-016-1798-3 PG 7 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA DN3SR UT WOS:000376984200002 PM 27086301 ER PT J AU Butler, AD Wynter, M Medina, VF Bednar, AJ AF Butler, Afrachanna D. Wynter, Michelle Medina, Victor F. Bednar, Anthony J. TI Depleted Uranium Toxicity, Accumulation, and Uptake in Cynodon dactylon (Bermuda) and Aristida purpurea (Purple Threeawn) SO BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY LA English DT Article DE Depleted uranium; Phyto-toxicity; Phytouptake; Translocation; Bioconcentration ID 3 GRASSES; SOIL; TRANSLOCATION; SPECIATION; GRADE AB Yuma Proving Grounds (YPG) in western Arizona is a testing range where Depleted uranium (DU) penetrators have been historically fired. A portion of the fired DU penetrators are being managed under controlled conditions by leaving them in place. The widespread use of DU in armor-penetrating weapons has raised environmental and human health concerns. The present study is focused on the onsite management approach and on the potential interactions with plants local to YPG. A 30 day study was conducted to assess the toxicity of DU corrosion products (e.g., schoepite and meta-schoepite) in two grass species that are native to YPG, Bermuda (Cynodon dactylon) and Purple Threeawn (Aristida purpurea). In addition, the ability for plants to uptake DU was studied. The results of this study show a much lower threshold for biomass toxicity and higher plant concentrations, particularly in the roots than shoots, compared to previous studies. C1 [Butler, Afrachanna D.; Wynter, Michelle; Medina, Victor F.; Bednar, Anthony J.] US Army Engineer Res & Dev Ctr ERDC, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS USA. RP Butler, AD (reprint author), US Army Engineer Res & Dev Ctr ERDC, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS USA. EM Afrachanna.D.Butler@usace.army.mil NR 33 TC 0 Z9 0 U1 6 U2 8 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0007-4861 EI 1432-0800 J9 B ENVIRON CONTAM TOX JI Bull. Environ. Contam. Toxicol. PD JUN PY 2016 VL 96 IS 6 BP 714 EP 719 DI 10.1007/s00128-016-1784-9 PG 6 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA DN3SR UT WOS:000376984200003 PM 27016940 ER PT J AU Russell, AL Martin, DP Cuddy, MF Bednar, AJ AF Russell, Amber L. Martin, David P. Cuddy, Michael F. Bednar, Anthony J. TI A Rapid, Fluorescence-Based Field Screening Technique for Organic Species in Soil and Water Matrices SO BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY LA English DT Article DE Field analysis; Oil screening; Rapid detection ID AROMATIC-HYDROCARBONS PAHS; OIL AB Real-time detection of hydrocarbon contaminants in the environment presents analytical challenges because traditional laboratory-based techniques are cumbersome and not readily field portable. In the current work, a method for rapid and semi-quantitative detection of organic contaminants, primarily crude oil, in natural water and soil matrices has been developed. Detection limits in the parts per million and parts per billion were accomplished when using visual and digital detection methods, respectively. The extraction technique was modified from standard methodologies used for hydrocarbon analysis and provides a straight-forward separation technique that can remove interference from complex natural constituents. For water samples this method is semi-quantitative, with recoveries ranging from 70 % to 130 %, while measurements of soil samples are more qualitative due to lower extraction efficiencies related to the limitations of field-deployable procedures. C1 [Russell, Amber L.; Martin, David P.; Cuddy, Michael F.; Bednar, Anthony J.] US Army, Environm Lab, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. RP Bednar, AJ (reprint author), US Army, Environm Lab, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Anthony.J.Bednar@usace.army.mil NR 16 TC 0 Z9 0 U1 1 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0007-4861 EI 1432-0800 J9 B ENVIRON CONTAM TOX JI Bull. Environ. Contam. Toxicol. PD JUN PY 2016 VL 96 IS 6 BP 773 EP 778 DI 10.1007/s00128-016-1771-1 PG 6 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA DN3SR UT WOS:000376984200013 PM 26988223 ER PT J AU Burgoon, LD AF Burgoon, Lyle D. TI A Market-Basket Approach to Predict the Acute Aquatic Toxicity of Munitions and Energetic Materials SO BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY LA English DT Article DE Computational toxicology; Quantitative structure activity relationship; Aquatic toxicology; QSAR; Predictive toxicology; Munitions; Energetics; Fish toxicity; Acute toxicity AB An ongoing challenge in chemical production, including the production of insensitive munitions and energetics, is the ability to make predictions about potential environmental hazards early in the process. To address this challenge, a quantitative structure activity relationship model was developed to predict acute fathead minnow toxicity of insensitive munitions and energetic materials. Computational predictive toxicology models like this one may be used to identify and prioritize environmentally safer materials early in their development. The developed model is based on the Apriori market-basket/frequent itemset mining approach to identify probabilistic prediction rules using chemical atom-pairs and the lethality data for 57 compounds from a fathead minnow acute toxicity assay. Lethality data were discretized into four categories based on the Globally Harmonized System of Classification and Labelling of Chemicals. Apriori identified toxicophores for categories two and three. The model classified 32 of the 57 compounds correctly, with a fivefold cross-validation classification rate of 74 %. A structure-based surrogate approach classified the remaining 25 chemicals correctly at 48 %. This result is unsurprising as these 25 chemicals were fairly unique within the larger set. C1 [Burgoon, Lyle D.] US Army, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. RP Burgoon, LD (reprint author), US Army, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM lyle.d.burgoon@usace.army.mil OI Burgoon, Lyle/0000-0003-4977-5352 FU U.S. Army Environmental Quality/Installation Technology Research Program FX Permission for publishing this information has been granted by the Chief of Engineers. Thanks to Drs. Natalia Vinas and Ed Perkins for comments on an earlier draft of this manuscript. The U.S. Army Environmental Quality/Installation Technology Research Program funded this work as part of the Rapid Hazard Assessment Focus Area. NR 6 TC 0 Z9 0 U1 1 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0007-4861 EI 1432-0800 J9 B ENVIRON CONTAM TOX JI Bull. Environ. Contam. Toxicol. PD JUN PY 2016 VL 96 IS 6 BP 779 EP 783 DI 10.1007/s00128-016-1800-0 PG 5 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA DN3SR UT WOS:000376984200014 PM 27091326 ER PT J AU Shukla, MK Poda, A AF Shukla, Manoj K. Poda, Aimee TI Adsorption of Emerging Munitions Contaminants on Cellulose Surface: A Combined Theoretical and Experimental Investigation SO BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY LA English DT Article DE 2,4-dinitroanisole (DNAN); 1,1-diamino-2,2-dinitroethene (FOX-7); 2,4,6-trinitrotoluene (TNT); Cellulose; Adsorption; DFT level ID QUARTZ-CRYSTAL MICROBALANCE; ENERGIES; FIBERS; FILMS; MODEL; TOOL AB This manuscript reports results of an integrated theoretical and experimental investigation of adsorption of two emerging contaminants (DNAN and FOX-7) and legacy compound TNT on cellulose surface. Cellulose was modeled as trimeric form of the linear chain of 1 -> 4 linked of beta-D-glucopyranos in C-4(1) chair conformation. Geometries of modeled cellulose, munitions compounds and their complexes were optimized at the M06-2X functional level of Density Functional Theory using the 6-31G(d,p) basis set in gas phase and in water solution. The effect of water solution was modeled using the CPCM approach. Nature of potential energy surfaces was ascertained through harmonic vibrational frequency analysis. Interaction energies were corrected for basis set superposition error and the 6-311G(d,p) basis set was used. Molecular electrostatic potential mapping was performed to understand the reactivity of the investigated systems. It was predicted that adsorbates will be weakly adsorbed on the cellulose surface in water solution than in the gas phase. C1 [Shukla, Manoj K.; Poda, Aimee] Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Shukla, MK (reprint author), Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. EM Manoj.K.Shukla@usace.army.mil RI Poda, Aimee/K-1905-2012 NR 18 TC 0 Z9 0 U1 7 U2 9 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0007-4861 EI 1432-0800 J9 B ENVIRON CONTAM TOX JI Bull. Environ. Contam. Toxicol. PD JUN PY 2016 VL 96 IS 6 BP 784 EP 790 DI 10.1007/s00128-016-1791-x PG 7 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA DN3SR UT WOS:000376984200015 PM 27084096 ER PT J AU Medina, VF Griggs, CS Thomas, C AF Medina, Victor F. Griggs, Chris S. Thomas, Catherine TI Evaluation of the Destruction of the Harmful Cyanobacteria, Microcystis aeruginosa, with a Cavitation and Superoxide Generating Water Treatment Reactor SO BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY LA English DT Article DE Cyanobacterial/harmful algal blooms (CHAB); Cyanobacteria; Microcystin; Superoxide; Cavitation ID HYDRODYNAMIC CAVITATION; TOXINS; LAKES; MECHANISMS; REMOVAL AB Cyanobacterial/Harmful Algal Blooms are a major issue for lakes and reservoirs throughout the U.S.A. An effective destructive technology could be useful to protect sensitive areas, such as areas near water intakes. The study presented in this article explored the use of a reactor called the KRIA Water Treatment System. The reactor focuses on the injection of superoxide (O-2 (-)), which is generated electrochemically from the atmosphere, into the water body. In addition, the injection process generates a significant amount of cavitation. The treatment process was tested in 190-L reactors spiked with water from cyanobacterial contaminated lakes. The treatment was very effective at destroying the predominant species of cyanobacteria, Microcystis aeruginosa, organic matter, and decreasing chlorophyll concentration. Microcystin toxin concentrations were also reduced. Data suggest that cavitation alone was an effective treatment, but the addition of superoxide improved performance, particularly regarding removal of cyanobacteria and reduction of microcystin concentration. C1 [Medina, Victor F.; Griggs, Chris S.; Thomas, Catherine] US Army, Engineer Res & Dev Ctr, CEERD EPE, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. RP Medina, VF (reprint author), US Army, Engineer Res & Dev Ctr, CEERD EPE, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM victor.f.medina@usace.army.mil FU Premier Materials Technology, Inc. of Minneapolis, MN; Aquatic Plant Control Research Program FX The authors would like to acknowledge the support of Premier Materials Technology, Inc. of Minneapolis, MN, who funded the project and the time to prepare this paper. Mr. Keith Boulais, CEO, was our primary contact. We also acknowledge the support by Mr. Mike Mangham of ECOUSA, who provided information on the operation of the KRIA reactor. A follow on project was funded by the Aquatic Plant Control Research Program, and some supplementary data were provided via this effort. NR 22 TC 0 Z9 0 U1 6 U2 12 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0007-4861 EI 1432-0800 J9 B ENVIRON CONTAM TOX JI Bull. Environ. Contam. Toxicol. PD JUN PY 2016 VL 96 IS 6 BP 791 EP 796 DI 10.1007/s00128-016-1742-6 PG 6 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA DN3SR UT WOS:000376984200016 PM 26846314 ER PT J AU Martin, S AF Martin, Sarah TI "Elementar, meu caro Watson": Jo Soares Reinvents the Classics SO HISPANIA-A JOURNAL DEVOTED TO THE TEACHING OF SPANISH AND PORTUGUESE LA English DT Article DE Brazil/Brasil; carnivalesque/carnavalesco; detective fiction/romance policial; Jo Soares; mysteries/misterios; parody/parodia; Sherlock Holmes AB Detective fiction with its roots primarily in Europe and the United States was slow to catch on in Brazil, where national authors did not attempt more than small forays into the genre for most of the twentieth century. This was due in large part to the particularities of Brazilian society, in which law enforcement agencies, rife with corruption, perpetuated the idea that a hero detective who dedicated himself to solving a crime was very foreign. The 1960s saw more Brazilian authors writing detective fiction. A boom in detective literature took place in the 1990s when the end of the dictatorship caused a relaxation of censorship. Among these authors was Jo Soares, whose 1995 novel O xango de Baker Street not only places a classical whodunit on Brazilian soil, but also adapts an icon of the genre, Sherlock Holmes, to Brazilian society. By using the Brazilian idea of the carnivalesque, Soares inverts the typical role of Holmes and reinvents the character in a decidedly Brazilian detective novel, rather than merely modifying the British format. C1 [Martin, Sarah] US Mil Acad, West Point, NY 10996 USA. RP Martin, S (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 18 TC 0 Z9 0 U1 0 U2 2 PU AMER ASSOC TEACHERS SPANISH PORTUGUESE, INC PI WALLED LAKE PA 900 LADD RD, WALLED LAKE, MI 48390 USA SN 0018-2133 EI 2153-6414 J9 HISPANIA-J DEV INTER JI Hispania-J. Devoted Teach. Span. Port. PD JUN PY 2016 VL 99 IS 2 BP 203 EP 211 PG 9 WC Linguistics; Language & Linguistics; Literature, Romance SC Linguistics; Literature GA DN6AE UT WOS:000377152200003 ER PT J AU Eberly, JO Indest, KJ Hancock, DE Jung, CM Crocker, FH AF Eberly, Jed O. Indest, Karl J. Hancock, Dawn E. Jung, Carina M. Crocker, Fiona H. TI Metagenomic analysis of denitrifying wastewater enrichment cultures able to transform the explosive, 3-nitro-1,2,4-triazol-5-one (NTO) SO JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY LA English DT Article DE NTO; Insensitive munitions; Metagenomics; Denitrification ID NITRATE-CONTAMINATED GROUNDWATER; AUTOTROPHIC DENITRIFICATION; HETEROTROPHIC DENITRIFICATION; BIOLOGICAL DENITRIFICATION; MICROBIAL DIVERSITY; BATCH EXPERIMENTS; STRAIN KTR9; REMOVAL; BIODEGRADATION; REMEDIATION AB Removal of 3-nitro-1,2,4-triazol-5-one (NTO) was investigated in conjunction with heterotrophic and autotrophic denitrifying growth conditions by a microbial consortium from a wastewater treatment plant. Microcosms were supplemented with molasses, methanol, or thiosulfate. Cultures were passaged twice by transferring 10 % of the culture volume to fresh media on days 11 and 21. Rates of NTO removal were 18.71 +/- 0.65, 9.04 +/- 2.61, and 4.34 +/- 2.72 mg/L/day while rates of nitrate removal were 20.08 +/- 1.13, 21.58 +/- 1.20, and 24.84 +/- 1.26 mg/L/day, respectively, for molasses, methanol, or thiosulfate. Metagenomic analysis showed that Proteobacteria and Firmicutes were the major phyla in the microbial communities. In molasses supplemented cultures, the community profile at the family level changed over time with Pseudomonadaceae the most abundant (67.4 %) at day 11, Clostridiaceae (65.7 %) at day 21, and Sporolactobacillaceae (35.4 %) and Clostridiaceae (41.0 %) at day 29. Pseudomonadaceae was the dominant family in methanol and thiosulfate supplemented cultures from day 21 to 29 with 76.6 and 81.6 % relative abundance, respectively. C1 [Eberly, Jed O.; Indest, Karl J.; Hancock, Dawn E.; Jung, Carina M.; Crocker, Fiona H.] US Army, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Indest, KJ (reprint author), US Army, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. EM Karl.J.Indest@usace.army.mil FU US Army Corps of Engineers Environmental Quality Program FX This research was funded through the US Army Corps of Engineers Environmental Quality Program. Views, opinions and/or findings contained herein are those of the authors and should not be construed as an official Department of the Army position or decision, unless so designated by other official documentation. NR 42 TC 0 Z9 0 U1 7 U2 11 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1367-5435 EI 1476-5535 J9 J IND MICROBIOL BIOT JI J. Ind. Microbiol. Biotechnol. PD JUN PY 2016 VL 43 IS 6 BP 795 EP 805 DI 10.1007/s10295-016-1755-5 PG 11 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA DN2ZA UT WOS:000376930500007 PM 27033535 ER PT J AU Jobe, O Trinh, HV Kim, J Alsalmi, W Tovanabutra, S Ehrenberg, PK Peachman, KK Gao, GF Thomas, R Kim, JH Michael, NL Alving, CR Rao, VB Rao, M AF Jobe, Ousman Trinh, Hung V. Kim, Jiae Alsalmi, Wadad Tovanabutra, Sodsai Ehrenberg, Philip K. Peachman, Kristina K. Gao, Guofen Thomas, Rasmi Kim, Jerome H. Michael, Nelson L. Alving, Carl R. Rao, Venigalla B. Rao, Mangala TI Effect of cytokines on Siglec-1 and HIV-1 entry in monocyte-derived macrophages: the importance of HIV-1 envelope V1V2 region SO JOURNAL OF LEUKOCYTE BIOLOGY LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; COLONY-STIMULATING FACTORS; NEUTRALIZING ANTIBODY PG9; TYPE-1; INFECTION; SIALOADHESIN; TRANSMISSION; REPLICATION; DIFFERENTIATION; SUSCEPTIBILITY AB Monocytes and monocyte-derived macrophages express relatively low levels of CD4. Despite this, macrophages can be effectively infected with human immunodeficiency virus type 1. Macrophages have a critical role in human immunodeficiency virus type 1 transmission; however, the mechanism or mechanisms of virus infection are poorly understood. We report that growth factors, such as granulocyte macrophage colony -stimulating factor and macrophage colony stimulating factor affect the phenotypic profile and permissiveness of macrophages to human immunodeficiency virus type 1. Human immunodeficiency virus type 1 infection of monocyte-derived macrophages derived from granulocyte macrophage and macrophage colony stimulating factors was predominantly facilitated by the sialic acid-binding immunoglobulin-like lectin-1. The number of sialic acid-binding immunoglobulin-like lectin receptors on macrophage colony -stimulating factor derived monocyte-derived macrophages was significantly greater than on granulocyte macrophage colony stimulating factor-derived monocyte-derived macrophages, and correspondingly, human immunodeficiency virus type 1 infection was greater in the macrophage colony -stimulating factor-derived monocyte-derived macrophages. Single-genome analysis and quantitative reverse transcriptase-polymerase chain reaction revealed that the differences in infectivity was not due to differences in viral fitness or in viral variants with differential infectivity but was due to reduced viral entry into the granulocyte macrophage colony -stimulating factor derived monocyte-derived macrophages. Anti-sialic acid binding immunoglobulin-like lectin, trimeric glycoprotein 145, and scaffolded V1V2 proteins were bound to sialic acid-binding immunoglobulin-like lectin and significantly reduced human immunodeficiency virus type 1 entry and infection. Furthermore, sialic acid residues present in the V1V2 region of the envelope protein mediated human immunodeficiency virus type 1 interaction with sialic acid-binding immunoglobulin-like lectin and entry into macrophage colony-stimulating factor-derived monocyte-derived macrophages. Removal of sialic acid residues or glycans from scaffolded V1V2 protein decreased human immunodeficiency virus type 1 infectivity. These results highlight the importance of sialic acids on the V1V2 region in binding to sialic acid -binding immunoglobulin-like lectin and suggest that the unusually long surface -exposed sialic acid -binding immunoglobulinlike lectin might aid in the capture and entry of human immunodeficiency virus type 1 into monocyte-derived macrophages. C1 [Jobe, Ousman; Trinh, Hung V.; Kim, Jiae; Tovanabutra, Sodsai; Ehrenberg, Philip K.; Peachman, Kristina K.; Gao, Guofen] Walter Reed Army Inst Res, Henry M Jackson Fdn Adv Mil Med, Silver Spring, MD USA. [Jobe, Ousman; Trinh, Hung V.; Kim, Jiae; Peachman, Kristina K.; Alving, Carl R.; Rao, Mangala] Walter Reed Army Inst Res, Lab Adjuvant & Antigen Res, Silver Spring, MD 20910 USA. [Tovanabutra, Sodsai; Kim, Jerome H.; Michael, Nelson L.] Walter Reed Army Inst Res, Lab Mol Virol & Pathogenesis, Viral Sequencing Core, Silver Spring, MD USA. [Ehrenberg, Philip K.; Thomas, Rasmi] Walter Reed Army Inst Res, US Mil HIV Res Program, Host Genet Sect, Silver Spring, MD USA. [Alsalmi, Wadad; Gao, Guofen; Rao, Venigalla B.] Catholic Univ Amer, Dept Biol, Washington, DC 20064 USA. RP Rao, M (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Lab Adjuvant & Antigen Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM mrao@hivresearch.org FU Swiss National Science Foundation; U.S. National Institutes of Health National Institute of Allergy and Infectious Diseases [AI102725]; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-11-2-0174]; U.S. Department of Defense FX H.V.T. was partially supported by a grant from the Swiss National Science Foundation. V.B.R. was partially supported by the U.S. National Institutes of Health National Institute of Allergy and Infectious Diseases (Grant AI102725). This work was supported by a cooperative agreement (W81XWH-11-2-0174) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense. We thank Kultida Poltavee for sequence analysis, Gustavo Kijak and Peter Phuc Pham for their assistance with phylogenetic analysis, Agnes-Laurence Chenine for providing the envelope-deficient HIV-1 (pSG3Delta env), and Sayali Onkar for her assistance in generating MDMs. NR 54 TC 1 Z9 1 U1 2 U2 3 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0741-5400 EI 1938-3673 J9 J LEUKOCYTE BIOL JI J. Leukoc. Biol. PD JUN PY 2016 VL 99 IS 6 BP 1089 EP 1106 DI 10.1189/jlb.2A0815-361R PG 18 WC Cell Biology; Hematology; Immunology SC Cell Biology; Hematology; Immunology GA DN2IN UT WOS:000376887400028 PM 26667473 ER PT J AU Kumar, A Hage-Hassan, J Baskaran, M Miller, CJ Selegean, JP Creech, CT AF Kumar, A. Hage-Hassan, J. Baskaran, M. Miller, C. J. Selegean, J. P. Creech, C. T. TI Multiple sediment cores from reservoirs are needed to reconstruct recent watershed changes from stable isotopes (delta C-13 and delta N-15) and C/N ratios: case studies from the mid-western United States SO JOURNAL OF PALEOLIMNOLOGY LA English DT Article DE Pb-210 and Cs-137 chronology; Sediment dating; Stable carbon and nitrogen isotopes; Reservoir sediment; Paleoenvironmental changes ID ENVIRONMENTAL-CHANGES; GEOCHEMICAL RECORD; ORGANIC-MATTER; LAKE-SEDIMENTS; EXCESS PB-210; CS-137; MICHIGAN; RATES; BE-7; RADIONUCLIDES AB Watershed land-use changes, including urbanization, have caused accelerated soil erosion, which in turn has increased sediment accumulation rates in most aging reservoirs in the mid-western United States (USA), thereby posing a threat to their longevity and productivity. We analyzed three sediment cores from each of two reservoirs in the mid-western USA, the Webber Dam impoundment in Michigan and Goshen Pond in Indiana. Core chronologies were established using Cs-137 and Pb-210. Concentrations of organic carbon and nitrogen and their stable isotope compositions (delta C-13 and delta N-15) were measured to investigate past land-use changes. We used three excess Pb-210-based (Pb-210(xs)) sedimentation rate models (constant Pb-210 flux and sedimentation, constant rate of supply of Pb-210 and constant initial Pb-210 concentration) to develop core chronologies and compared them to the chronology obtained from the Cs-137 peak. Validation of the excess Pb-210-based chronology with(137)Cs-based chronology requires more than one Pb-210(xs)-based-model. That is, even in one watershed, output from more than one Pb-210(xs)-based model may have to be compared with an independent time marker. We compared C/N ratios, delta C-13 and delta N-15 among three time horizons in each of the three cores from the reservoirs (corresponding to dates of 1950, 1970 and 2010). Within a reservoir, there can be large differences between cores for a given time horizon, indicating there could be spatial differences in sources of C and N and the processes that influence carbon and nitrogen isotopes. We conclude that multiple sediment cores from reservoirs should be analyzed if carbon and nitrogen isotopes in sediments are to be used for paleoenvironmental inference. C1 [Kumar, A.; Hage-Hassan, J.; Baskaran, M.] Wayne State Univ, Dept Geol, Detroit, MI 48202 USA. [Miller, C. J.] Wayne State Univ, Dept Civil & Environm Engn, Detroit, MI 48202 USA. [Selegean, J. P.; Creech, C. T.] US Army, Corps Engineers, Detroit, MI 48226 USA. RP Baskaran, M (reprint author), Wayne State Univ, Dept Geol, Detroit, MI 48202 USA. EM Baskaran@wayne.edu FU U.S. Army Corps of Engineers [W911XK-10-C-0011, W911XK-14-C-0023] FX We thank Robin Heichel for help with sample preparation for stable isotope analysis. We thank John Barkach for assisting us with the sediment core collection. This project was funded by the U.S. Army Corps of Engineers (W911XK-10-C-0011 and W911XK-14-C-0023). We thank the two anonymous reviewers for their in-depth review of our manuscript. We thank Editor Mark Brenner for a thorough editing of the manuscript. NR 39 TC 0 Z9 0 U1 9 U2 15 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0921-2728 EI 1573-0417 J9 J PALEOLIMNOL JI J. Paleolimn. PD JUN PY 2016 VL 56 IS 1 BP 15 EP 31 DI 10.1007/s10933-016-9888-0 PG 17 WC Environmental Sciences; Geosciences, Multidisciplinary; Limnology SC Environmental Sciences & Ecology; Geology; Marine & Freshwater Biology GA DN2KX UT WOS:000376893600002 ER PT J AU Kunces, LJ Johnson, EC Munoz, CX Hydren, JR Huggins, RA Judelson, DA Ganio, MS Vingren, JL Volek, JS Armstrong, LE AF Kunces, Laura J. Johnson, Evan C. Munoz, Colleen X. Hydren, Jay R. Huggins, Robert A. Judelson, Daniel A. Ganio, Mathew S. Vingren, Jakob L. Volek, Jeff S. Armstrong, Lawrence E. TI OBSERVED DIETARY PRACTICES OF RECREATIONAL ULTRAENDURANCE CYCLISTS IN THE HEAT SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH LA English DT Article DE athletes; nutrition; macronutrients; carbohydrates ID SUBMAXIMAL EXERCISE; PERFORMANCE; OXIDATION; ENDURANCE AB Dietary approaches for optimizing exercise performance have been debated in the literature for years. For endurance athletes, various position stands focus on recommendations for high-carbohydrate diets to maximize performance in events. However, theories of low-carbohydrate diets and their ability to provide more fuel may prove beneficial to ultraendurance athletes. Therefore, the purpose of this research was to observe the food and fluid consumption of successful recreational ultraendurance cyclists on the day before (ED-1), Event Day, and the day after (ED+1), a 162 km endurance event in a hot environment, and subsequently compare dietary intakes to recommendations and other observed dietary practices. Twenty men (age, 48 +/- 8 years; mass, 85.1 +/- 13.4 kg; height, 178.2 +/- 7.4 cm) recorded all dietary items during ED-1, Event Day, and ED+1. Diet composition and the relationships between carbohydrate and caloric intake with finish time were examined. Results show athletes consumed a high-carbohydrate diet on ED-1 (384 g.d(-1)), Event Day (657 g.d(-1)), and ED+1 (329 g.d(-1)). However, there were no significant associations between carbohydrate (p > 0.05), or caloric intake (p > 0.05), and finish time. This study results great variation in diets of recreational endurance cyclists, although most consume within nationally recognized dietary recommendation ranges. Because there is great variation and lack of correlation with performance, these findings suggest that current high-carbohydrate dietary recommendations for general endurance athletes may not be sport specific or individualized enough for recreational ultraendurance cyclists, and that individualized dietary macronutrient composition manipulations may improve performance outcomes. C1 [Kunces, Laura J.] EXOS, Phoenix, AZ USA. [Johnson, Evan C.] Univ Arkansas, Fayetteville, AR 72701 USA. [Munoz, Colleen X.; Huggins, Robert A.; Armstrong, Lawrence E.] Univ Connecticut, Storrs, CT USA. [Hydren, Jay R.] US Army, Environm Med Res Inst, Natick, MA 01760 USA. [Judelson, Daniel A.] Calif State Univ Fullerton, Fullerton, CA 92634 USA. [Vingren, Jakob L.] Univ N Texas, Denton, TX 76203 USA. [Volek, Jeff S.] Ohio State Univ, Columbus, OH 43210 USA. RP Kunces, LJ (reprint author), EXOS, Phoenix, AZ USA. EM LKunces@gmail.com NR 16 TC 0 Z9 0 U1 3 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1064-8011 EI 1533-4287 J9 J STRENGTH COND RES JI J. Strength Cond. Res. PD JUN PY 2016 VL 30 IS 6 BP 1607 EP 1612 PG 6 WC Sport Sciences SC Sport Sciences GA DN5LC UT WOS:000377107900015 PM 26492102 ER PT J AU Belmont, PJ Owens, BD Schoenfeld, AJ AF Belmont, Philip J. Owens, Brett D. Schoenfeld, Andrew J. TI Musculoskeletal Injuries in Iraq and Afghanistan: Epidemiology and Outcomes Following a Decade of War SO JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS LA English DT Review ID OPERATION ENDURING FREEDOM; BRIGADE COMBAT TEAM; SPINAL-INJURIES; EXTREMITY WOUNDS; ARMY; POPULATION; CASUALTIES; DISEASE AB The combined wars in Afghanistan and Iraq represent the longest ongoing conflicts in American military history, with a combined casualty estimate of >59,000 service members. The nature of combat over the last decade has led to precipitous increases in severe orthopaedic injuries, including traumatic amputations and injuries to the spine. Nearly 75% of all injuries sustained in combat now are caused by explosive mechanisms, and fractures comprise 40% of all musculoskeletal injuries. Injuries to the axial skeleton are more frequent among personnel exposed to combat, and spinal trauma is identified in nearly 40% of those killed. Musculoskeletal injuries are expensive and generate some of the highest rates of long-term disability. Noncombat musculoskeletal injuries are endemic within deployed military service members and occur at a greater than threefold rate compared with combat musculoskeletal injuries. Service members with musculoskeletal injuries or behavioral health conditions, such as posttraumatic stress disorder, depression, and psychosis, and those occupying a low socioeconomic status, have an increased risk of inferior outcomes. C1 [Belmont, Philip J.] William Beaumont Army Med Ctr, Dept Orthoped Surg & Rehabil, El Paso, TX 79920 USA. [Owens, Brett D.] Keller Army Community Hosp, Dept Orthoped, West Point, NY USA. [Schoenfeld, Andrew J.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Orthopaed Surg, Boston, MA 02115 USA. RP Belmont, PJ (reprint author), William Beaumont Army Med Ctr, Dept Orthoped Surg & Rehabil, El Paso, TX 79920 USA. OI Schoenfeld, Andrew/0000-0002-3691-1215 NR 32 TC 0 Z9 0 U1 1 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1067-151X EI 1940-5480 J9 J AM ACAD ORTHOP SUR JI J. Am. Acad. Orthop. Surg. PD JUN PY 2016 VL 24 IS 6 BP 341 EP 348 DI 10.5435/JAAOS-D-15-00123 PG 8 WC Orthopedics; Surgery SC Orthopedics; Surgery GA DN1GH UT WOS:000376813800002 PM 27115793 ER PT J AU Kucera, KL Marshall, SW Wolf, SH Padua, DA Cameron, KL Beutler, AI AF Kucera, Kristen L. Marshall, Stephen W. Wolf, Susanne H. Padua, Darin A. Cameron, Kenneth L. Beutler, Anthony I. TI Association of Injury History and Incident Injury in Cadet Basic Military Training SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE EPIDEMIOLOGY; LOWER EXTREMITY; ANKLE; KNEE; RISK FACTORS ID EXERCISE-RELATED INJURIES; FEMALE ARMY TRAINEES; RISK-FACTORS; MUSCULOSKELETAL INJURIES; MEDICAL SURVEILLANCE; YOUTH SOCCER; PREVENTION; SCHOOL; PROGRAM; SPORTS AB Purpose This study aimed to determine the association between injury history at enrollment and incident lower extremity (LE) injury during cadet basic training among first-year military cadets. Methods Medically treated LE injuries during cadet basic training documented in the Defense Medical Surveillance System were ascertained in a prospective cohort study of three large US military academies from 2005 to 2008. Both acute injuries (International Classification of Disease, Ninth Revision, codes in the 800-900s, including fracture, dislocations, and sprains/strains) and injury-related musculoskeletal injuries (International Classification of Disease, Ninth Revision, codes in the 700s, including inflammation and pain, joint derangement, stress fracture, sprain/strain/rupture, and dislocation) were included. Risk ratio (RR) and 95% confidence interval (CI) were computed using multivariate log-binomial models stratified by gender. Results During basic training, there were 1438 medically treated acute and 1719 musculoskeletal-related LE injuries in the 9811 cadets. The most frequent LE injuries were sprains/strains (73.6% of acute injuries) and inflammation and pain (89.6% of musculoskeletal-related injuries). The overall risk of incident LE injury was 23.2% (95% CI = 22.3%-24.0%). Cadets with a history of LE injury were at increased risk for incident LE injury. This association was identical in males (RR = 1.74, 95% CI = 1.55-1.94) and females (RR = 1.74, 95% CI = 1.52-1.99). In site-specific analyses, strong associations between injury history and incident injury were observed for hip, knee ligament, stress fracture, and ankle sprain. Injury risk was greater (P < 0.01) for females (39.1%) compared with males (18.0%). The elevated injury risk in females (RR = 2.19, 95% CI = 2.04-2.36) was independent of injury history (adjusted RR = 2.09, 95% CI = 1.95-2.24). Conclusion Injury history upon entry to the military is associated with the incidence of LE injuries sustained during cadet basic training. Prevention programs targeted at modifiable factors in cadets with a history of LE injury should be considered. C1 [Kucera, Kristen L.; Padua, Darin A.] Univ N Carolina, Dept Exercise & Sports Sci, 209 Fetzer Hall, Chapel Hill, NC 27599 USA. [Marshall, Stephen W.; Wolf, Susanne H.] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA. [Padua, Darin A.] Univ N Carolina, Sports Med Res Lab, Chapel Hill, NC USA. [Cameron, Kenneth L.] US Mil Acad, Keller Army Hosp, John Feagin Jr Sports Med Fellowship, West Point, NY USA. [Beutler, Anthony I.] Uniformed Serv Univ Hlth Sci, Dept Family Med, Bethesda, MD 20814 USA. RP Kucera, KL (reprint author), Univ N Carolina, Dept Exercise & Sports Sci, 209 Fetzer Hall, Chapel Hill, NC 27599 USA. EM kkucera@email.unc.edu OI Cameron, Kenneth/0000-0002-6276-4482 FU National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health [R01-AR054061001]; American Orthopedic Society for Sports Medicine; National Center for Injury Prevention and Control, Centers for Disease Control and Prevention [R49/CE002479] FX The JUMP-ACL study was funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health (R01-AR054061001). Pilot work was supported by the American Orthopedic Society for Sports Medicine. Dr. Stephen W. Marshall and the University of North Carolina Injury Prevention Research Center are partially supported by an award from the National Center for Injury Prevention and Control, Centers for Disease Control and Prevention (R49/CE002479). The views and opinions expressed are those of the authors and do not reflect the official policy of the US Service Academies, the Department of Defense, or the US Government. Special thanks to all the cadets who participated in this study and to service academies that supported the study. We would also like to acknowledge the members of the JUMP-ACL study team. From the UNC-CH: Shrikant Bangdiwala, Ph.D.; Bing Yu, Ph.D.; Michelle Boling, Ph.D., A.T.C.; Chuck Thigpen, Ph.D., P.T., A.T.C.; Lindsay Strickland, Ph.D., A.T.C.; Ben Goeger, Ph.D., A.T.C.; Candice Goerger, M.S., A.T.C.; Melanie McGrath, Ph.D., A.T.C.; David Bell, M.Ed., Ph.D., A.T.C.; and Kevin Guskiewicz, Ph.D., A.T.C. From other universities: William E. Garrett Ph.D., M.D. (Duke University); COL(Ret) Dean Taylor, M.D. (Duke University); Julie Gilchrist, M.D. (Centers for Disease Control and Prevention); and James Onate Ph.D., A.T.C. (Old Dominion University). From the USNA: CDR Scott Pyne, M.D.; CDR David Keblish, M.D.; CDR Sean Kelly, M.D.; and Gregg Calhoon, A.T.C. From the USAFA: COL John Tokish, M.D.; Barbara Coley; and COL Robert Sullivan, M.D. From the USMA: Karen Y. Peck, M.Ed., A.T.C.; COL (Ret) Thomas M. DeBerardino, M.D.; Sally B. Mountcastle, Ph.D.; COL (Ret) Paul D. Stoneman, P.T., Ph.D.; COL Steven J. Svoboda, M.D.; and LTC(P) Brett D. Owens, M.D. NR 31 TC 0 Z9 0 U1 1 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD JUN PY 2016 VL 48 IS 6 BP 1053 EP 1061 DI 10.1249/MSS.0000000000000872 PG 9 WC Sport Sciences SC Sport Sciences GA DM8MO UT WOS:000376617900010 PM 26765627 ER PT J AU Ishizuka, AS Lyke, KE DeZure, A Berry, AA Richie, TL Mendoza, FH Enama, ME Gordon, IJ Chang, LJ Sarwar, UN Zephir, KL Holman, LA James, ER Billingsley, PF Gunasekera, A Chakravarty, S Manoj, A Li, ML Ruben, AJ Li, T Eappen, AG Stafford, RE Natasha, KC Murshedkar, T DeCederfelt, H Plummer, SH Hendel, CS Novik, L Costner, PJM Saunders, JG Laurens, MB Plowe, CV Flynn, B Whalen, WR Todd, JP Noor, J Rao, S Sierra-Davidson, K Lynn, GM Epstein, JE Kemp, MA Fahle, GA Mikolajczak, SA Fishbaugher, M Sack, BK Kappe, SHI Davidson, SA Garver, LS Bjorkstrom, NK Nason, MC Graham, BS Roederer, M Sim, BKL Hoffman, SL Ledgerwood, JE Seder, RA AF Ishizuka, Andrew S. Lyke, Kirsten E. DeZure, Adam Berry, Andrea A. Richie, Thomas L. Mendoza, Floreliz H. Enama, Mary E. Gordon, Ingelise J. Chang, Lee-Jah Sarwar, Uzma N. Zephir, Kathryn L. Holman, LaSonji A. James, Eric R. Billingsley, Peter F. Gunasekera, Anusha Chakravarty, Sumana Manoj, Anita Li, MingLin Ruben, Adam J. Li, Tao Eappen, Abraham G. Stafford, Richard E. Natasha, K. C. Murshedkar, Tooba DeCederfelt, Hope Plummer, Sarah H. Hendel, Cynthia S. Novik, Laura Costner, Pamela J. M. Saunders, Jamie G. Laurens, Matthew B. Plowe, Christopher V. Flynn, Barbara Whalen, William R. Todd, J. P. Noor, Jay Rao, Srinivas Sierra-Davidson, Kailan Lynn, Geoffrey M. Epstein, Judith E. Kemp, Margaret A. Fahle, Gary A. Mikolajczak, Sebastian A. Fishbaugher, Matthew Sack, Brandon K. Kappe, Stefan H. I. Davidson, Silas A. Garver, Lindsey S. Bjorkstrom, Niklas K. Nason, Martha C. Graham, Barney S. Roederer, Mario Sim, B. Kim Lee Hoffman, Stephen L. Ledgerwood, Julie E. Seder, Robert A. CA VRC 312& VRC Study Teams TI Protection against malaria at 1 year and immune correlates following PfSPZ vaccination SO NATURE MEDICINE LA English DT Article ID DELTA-T-CELLS; NONREPLICATING SPOROZOITE VACCINE; PLASMODIUM-FALCIPARUM; MONOCLONAL-ANTIBODIES; LIVER STAGES; IMMUNIZATION; MICE; EFFICACY; BERGHEI; MEMORY AB An attenuated Plasmodium falciparum (Pf) sporozoite (SPZ) vaccine, PfSPZ Vaccine, is highly protective against controlled human malaria infection (CHMI) 3 weeks after immunization, but the durability of protection is unknown. We assessed how vaccine dosage, regimen, and route of administration affected durable protection in malaria-naive adults. After four intravenous immunizations with 2.7 x 10(5) PfSPZ, 6/11 (55%) vaccinated subjects remained without parasitemia following CHMI 21 weeks after immunization. Five non-parasitemic subjects from this dosage group underwent repeat CHMI at 59 weeks, and none developed parasitemia. Although Pf-specific serum antibody levels correlated with protection up to 21-25 weeks after immunization, antibody levels waned substantially by 59 weeks. Pf-specific T cell responses also declined in blood by 59 weeks. To determine whether T cell responses in blood reflected responses in liver, we vaccinated nonhuman primates with PfSPZ Vaccine. Pf-specific interferon-g-producing CD8 T cells were present at similar to 100-fold higher frequencies in liver than in blood. Our findings suggest that PfSPZ Vaccine conferred durable protection to malaria through long-lived tissue-resident T cells and that administration of higher doses may further enhance protection. C1 [Ishizuka, Andrew S.; DeZure, Adam; Mendoza, Floreliz H.; Enama, Mary E.; Gordon, Ingelise J.; Chang, Lee-Jah; Sarwar, Uzma N.; Zephir, Kathryn L.; Holman, LaSonji A.; Plummer, Sarah H.; Hendel, Cynthia S.; Novik, Laura; Costner, Pamela J. M.; Saunders, Jamie G.; Flynn, Barbara; Whalen, William R.; Todd, J. P.; Noor, Jay; Rao, Srinivas; Sierra-Davidson, Kailan; Lynn, Geoffrey M.; Graham, Barney S.; Roederer, Mario; Ledgerwood, Julie E.; Seder, Robert A.] NIAID, VRC, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA. [Lyke, Kirsten E.; Berry, Andrea A.; Laurens, Matthew B.; Plowe, Christopher V.] Univ Maryland, Sch Med, Inst Global Hlth, Ctr Vaccine Dev, Baltimore, MD 21201 USA. [Lyke, Kirsten E.; Berry, Andrea A.; Laurens, Matthew B.; Plowe, Christopher V.] Univ Maryland, Sch Med, Div Malaria Res, Baltimore, MD 21201 USA. [Richie, Thomas L.; James, Eric R.; Billingsley, Peter F.; Gunasekera, Anusha; Chakravarty, Sumana; Manoj, Anita; Li, MingLin; Ruben, Adam J.; Li, Tao; Eappen, Abraham G.; Stafford, Richard E.; Natasha, K. C.; Murshedkar, Tooba; Sim, B. Kim Lee; Hoffman, Stephen L.] Sanaria Inc, Rockville, MD USA. [Li, MingLin; Stafford, Richard E.; Natasha, K. C.; Sim, B. Kim Lee] Prot Potential LLC, Rockville, MD USA. [DeCederfelt, Hope] NIH, Ctr Clin, Pharmaceut Dev Sect, Bethesda, MD 20892 USA. [Epstein, Judith E.] NMRC, Malaria Dept, Silver Spring, MD USA. [Kemp, Margaret A.; Fahle, Gary A.] NIH, Ctr Clin, Dept Lab Med, Bethesda, MD 20892 USA. [Mikolajczak, Sebastian A.; Fishbaugher, Matthew; Sack, Brandon K.; Kappe, Stefan H. I.] Ctr Infect Dis Res, Seattle, WA USA. [Davidson, Silas A.; Garver, Lindsey S.] Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD USA. [Bjorkstrom, Niklas K.] Karolinska Inst, Karolinska Univ Hosp, Dept Med Huddinge, Ctr Infect Med, Stockholm, Sweden. [Nason, Martha C.] NIAID, Biostat Res Branch, Div Clin Res, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA. [Chang, Lee-Jah] Sanofi, Swiftwater, PA USA. [Sarwar, Uzma N.] Montefiore Med Ctr, Albert Einstein Coll Med, New York, NY USA. [Rao, Srinivas] Sanofi, Cambridge, MA USA. RP Seder, RA (reprint author), NIAID, VRC, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA. EM rseder@mail.nih.gov RI Laurens, Matthew/E-7293-2013; OI Laurens, Matthew/0000-0003-3874-581X; Ishizuka, Andrew/0000-0002-3024-7536; Bjorkstrom, Niklas/0000-0002-0967-076X; Mikolajczak, Sebastian/0000-0003-1996-9703 FU VRC, NIAID, NIH; NIAID [5R44AI055229-11, 5R44AI058499-08, 5R44AI058375-08]; Bill and Melinda Gates Foundation [24922]; [6000.RADI.F.A0309] FX The authors thank the vaccine trials participants for their contribution and commitment to vaccine research. We acknowledge the contributions of: our US National Institutes of Health (NIH) Clinical Center (CC) and National Institute of Allergy and Infectious Diseases (NIAID) colleagues, especially J. Stein, J. Pierson, R. Eckes, P. Driscoll, L. Ediger, and the nursing staff of the 5NW, SCSU, 5SE-S, and 5SE-N units; our VRC colleagues, especially A. Mittelman, H. Harvey, M. Young, C. Artis, R. Hicks, P. Darrah, and T. Abram; our Sanaria and Protein Potential colleagues, especially Y. Abebe, J. Jackson, A. Awe, M. King, H. Huang, A. Patil, S. Matheny, J. Overby, Y. Wen, K. Nelson, V. Pich, M. Orozco, D. Padilla, E. Saverino, B. Jiang, L. Gao, R. Xu, E. Fomumbod, M. Laskowski, T. T. Wai, F. Beams, R. Thompson, and A. Hoffman for administrative, operations, and legal support, and T. Luke for insight and inspiration; the EMMES Corporation; the NIAID Institutional Review Board; the NIAID Office of Communications and Government Relations; the NIH CC Department of Laboratory Medicine; the NIH CC IND Pharmacy, and the NIH CC Patient Recruitment and Public Liaison Office. We appreciate the expert reviews of the Safety Monitoring Committee (A. Durbin, K. Kester, and A. Cross) and the assistance from the US Military Malaria Vaccine Program, the Walter Reed Army Institute of Research Entomology Branch, and the Naval Medical Research Center (NMRC), especially A. Reyes, Y. Alcorta, G. Banania, C. Fedders, M. Dowler, T. Savransky, D. Patel, C. Brando, K. Kobylinski, and K. Walker. This work was supported by the intramural research program of the VRC, NIAID, NIH. Production and characterization of the PfSPZ Vaccine were supported in part by NIAID Small Business Innovation Research grants 5R44AI055229-11 (S. L. H.), 5R44AI058499-08 (S. L. H.), and 5R44AI058375-08 (S. L. H.). The humanized mouse experiments reported here were funded by the Bill and Melinda Gates Foundation (Investment ID: 24922; to S. H. I. K.). The findings and conclusions in this report are those of the authors and do not necessarily reflect the views of the funding agency or collaborators. The views expressed in this article are those of the author and do not necessarily reflect the official policy or position of the Department of the Navy, the Department of the Army, the Department of Defense, or the US Government. This work was supported in part by work unit number 6000.RADI.F.A0309 to NMRC. J. E. E. and S. A. D. are military service members, and this work was prepared as part of their official duties. Title 17 U.S.C. $101 defines a US Government work as a work prepared by a military service member or employee of the US Government as part of that person's official duties. NR 49 TC 15 Z9 15 U1 5 U2 8 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1078-8956 EI 1546-170X J9 NAT MED JI Nat. Med. PD JUN PY 2016 VL 22 IS 6 BP 614 EP + DI 10.1038/nm.4110 PG 13 WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental Medicine GA DO0NQ UT WOS:000377476000014 PM 27158907 ER PT J AU Menger, RP Wolf, ME Lang, RW Smith, DR Nanda, A Letarte, P Rosner, MK AF Menger, Richard P. Wolf, Michael E. Lang, Richard W. Smith, Donald R. Nanda, Anil Letarte, Peter Rosner, Michael K. TI Military Neurosurgery: A Range of Service Options SO NEUROSURGERY LA English DT Article DE Military neurosurgery; Military service; Socioeconomic analysis; United States Air Force; United States Army; United States Navy ID EXPERIENCE AB The pathway to military neurosurgical practice can include a number of accession options. This article is an objective comparison of fiscal, tangible, and intangible benefits provided through different military neurosurgery career paths. Neurosurgeons may train through active duty, reserve, or civilian pathways. These modalities were evaluated on the basis of economic data during residency and the initial 3 years afterwards. When available, military base pay, basic allowance for housing and subsistence, variable special pay, board certified pay, incentive pay, multiyear special pay, reserve drill pay, civilian salary, income tax, and other tax incentives were analyzed using publically available data. Civilians had lower residency pay, higher starting salaries, increased taxes, malpractice insurance cost, and increased overhead. Active duty service saw higher residency pay, lower starting salary, tax incentives, increased benefits, and almost no associated overhead including malpractice coverage. Reserve service saw a combination of civilian benefits with supplementation of reserve drill pay in return for weekend drill and the possibility of deployment and activation. Being a neurosurgeon in the military is extremely rewarding. From a financial perspective, ignoring intangibles, this article shows most entry pathways with initially modest differences between the cumulative salaries of active duty and civilian career paths and with higher overall compensation available from the reserve service option. These pathways become increasingly discrepant over time as civilian pay greatly exceeds that of military neurosurgeons. We hope that those curious about or considering serving in the United States military benefit from our accounting and review of these comparative paths.ABBREVIATIONS:FAP, Financial Assistance ProgramNADDS, Navy Active Duty Delay for SpecialistsTMS, Training in Medical Specialties C1 [Menger, Richard P.; Smith, Donald R.; Nanda, Anil] Louisiana State Univ Hlth Sci, Dept Neurosurg, Shreveport, LA USA. [Wolf, Michael E.] Air Test & Evaluat Squadron Three Zero, Dept Aerosp Med, Point Mugu Nawc, CA USA. [Menger, Richard P.; Wolf, Michael E.; Lang, Richard W.; Letarte, Peter] US Navy, Philadelphia, PA USA. [Smith, Donald R.] US Air Force, Boulder, CO USA. [Letarte, Peter] Loyola Univ, Med Ctr, Dept Neurol Surg, 2160 S 1st Ave, Maywood, IL 60153 USA. [Rosner, Michael K.] Walter Reed Natl Mil Med Ctr, Neurosurg Serv, Bethesda, MD USA. [Rosner, Michael K.] US Army, Boulder, CO USA. RP Menger, RP (reprint author), 1501 Kings Highway, Shreveport, LA 71103 USA. EM richard.menger@gmail.com NR 12 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-396X J9 NEUROSURGERY JI Neurosurgery PD JUN PY 2016 VL 78 IS 6 BP 765 EP 773 DI 10.1227/NEU.0000000000001084 PG 9 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA DN2GO UT WOS:000376882300016 PM 26528672 ER PT J AU Scerbo, MH Kaplan, HB Dua, A Litwin, DB Ambrose, CG Moore, LJ Murray, CK Wade, CE Holcomb, JB AF Scerbo, Michelle H. Kaplan, Heidi B. Dua, Anahita Litwin, Douglas B. Ambrose, Catherine G. Moore, Laura J. Murray, Clinton K. Wade, Charles E. Holcomb, John B. TI Beyond Blood Culture and Gram Stain Analysis: A Review of Molecular Techniques for the Early Detection of Bacteremia in Surgical Patients SO SURGICAL INFECTIONS LA English DT Review ID REAL-TIME PCR; INADEQUATE ANTIMICROBIAL TREATMENT; PERFORMANCE IMPROVEMENT PROGRAM; POLYMERASE-CHAIN-REACTION; FLIGHT MASS-SPECTROMETRY; CRITICALLY-ILL PATIENTS; INTENSIVE-CARE UNITS; HUMAN SEPTIC SHOCK; STREAM INFECTIONS; SEVERE SEPSIS AB Background: Sepsis from bacteremia occurs in 250,000 cases annually in the United States, has a mortality rate as high as 60%, and is associated with a poorer prognosis than localized infection. Because of these high figures, empiric antibiotic administration for patients with systemic inflammatory response syndrome (SIRS) and suspected infection is the second most common indication for antibiotic administration in intensive care units (ICU)s. However, overuse of empiric antibiotics contributes to the development of opportunistic infections, antibiotic resistance, and the increase in multi-drug-resistant bacterial strains. The current method of diagnosing and ruling out bacteremia is via blood culture (BC) and Gram stain (GS) analysis. Methods: Conventional and molecular methods for diagnosing bacteremia were reviewed and compared. The clinical implications, use, and current clinical trials of polymerase chain reaction (PCR)-based methods to detect bacterial pathogens in the blood stream were detailed. Results: BC/GS has several disadvantages. These include: some bacteria do not grow in culture media; others do not GS appropriately; and cultures can require up to 5 d to guide or discontinue antibiotic treatment. PCR-based methods can be potentially applied to detect rapidly, accurately, and directly microbes in human blood samples. Conclusions: Compared with the conventional BC/GS, particular advantages to molecular methods (specifically, PCR-based methods) include faster results, leading to possible improved antibiotic stewardship when bacteremia is not present. C1 [Scerbo, Michelle H.; Moore, Laura J.; Wade, Charles E.; Holcomb, John B.] Univ Texas Hlth Sci Ctr Houston, Dept Surg, Ctr Translat Injury Res CeTIR, Houston, TX 77030 USA. [Kaplan, Heidi B.; Litwin, Douglas B.] Univ Texas Hlth Sci Ctr Houston, Dept Microbiol & Mol Genet, Houston, TX 77030 USA. [Ambrose, Catherine G.] Univ Texas Hlth Sci Ctr Houston, Dept Orthoped Surg, Houston, TX 77030 USA. [Dua, Anahita] Med Coll Wisconsin, Dept Surg, 8700 W Wisconsin Ave, Milwaukee, WI 53226 USA. [Murray, Clinton K.] Brooke Army Med Ctr, Dept Med, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. RP Scerbo, MH (reprint author), Univ Texas Hlth Sci Ctr Houston, Dept Surg, UTP 1100-26 6410 Fannin St, Houston, TX 77030 USA. EM Michelle.l.scerbo@uth.tmc.edu FU NIGMS NIH HHS [T32 GM008792] NR 85 TC 1 Z9 1 U1 1 U2 4 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1096-2964 EI 1557-8674 J9 SURG INFECT JI Surg. Infect. PD JUN PY 2016 VL 17 IS 3 BP 294 EP 302 DI 10.1089/sur.2015.099 PG 9 WC Infectious Diseases; Surgery SC Infectious Diseases; Surgery GA DN5MQ UT WOS:000377113200004 PM 26918696 ER PT J AU Hruby, A Bulathsinhala, L McKinnon, CJ Hill, OT Montain, SJ Young, AJ Smith, TJ AF Hruby, Adela Bulathsinhala, Lakmini McKinnon, Craig J. Hill, Owen T. Montain, Scott J. Young, Andrew J. Smith, Tracey J. TI BMI and Lower Extremity Injury in US Army Soldiers, 2001-2011 SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID RISK-FACTORS; MUSCULOSKELETAL INJURIES; PHYSICAL-FITNESS; UNITED-STATES; RECRUITS; OBESITY; OVERWEIGHT; INFANTRY AB Introduction: Little data exist regarding the long-term impact of excess weight on lower extremity musculoskeletal injury/disorder (MID) in U.S. Army Soldiers. This prospective analysis examines the association between BMI of Soldiers at accession and risk of MID. Methods: A total of 736,608 Soldiers were followed from accession into the Army, 2001-2011. Data were analyzed January through March 2015. MID was categorized as any first incident lower extremity musculoskeletal injury/disorder, and secondarily, as first incident injury/disorder at a specific site (i.e., hips, upper legs/thighs, knees, lower legs/ankles, feet/toes). Multivariable-adjusted proportional hazards models estimated associations between BMI category at accession and MID risk. Results: During 15,678,743 person-months of follow-up, 411,413 cases of any first MID were documented (70,578 hip, 77,050 upper leg, 162,041 knee, 338,080 lower leg, and 100,935 foot injuries in secondary analyses). The overall MID rate was 2.62 per 100 person-months. Relative to Soldiers with normal BMI (18.5 to <25 kg/m(2)) at accession, those who were underweight (<18.5); overweight (25 to <30); or obese (>= 30) had 7%, 11%, and 33% higher risk of MID, respectively, after adjustment. Risks were highest in Soldiers who were obese at accession, and lowest in those with a BMI of 21-23 kg/m(2). Conclusions: Soldier BMI at accession has important implications for MID. A BMI of 21-23 kg/m(2) in newly accessing Soldiers was associated with the lowest risk of incident MID, suggesting that accession be limited to people within this range to reduce overall incidence of MID among service personnel. Published by Elsevier Inc. on behalf of American Journal of Preventive Medicine C1 [Hruby, Adela; Montain, Scott J.; Young, Andrew J.; Smith, Tracey J.] US Army Res Inst Environm Med, Mil Nutr Div, 15 Gen Greene Ave,Bldg 42, Natick, MA 01760 USA. [Hruby, Adela] Harvard Univ, Dept Nutr, TH Chan Sch Publ Hlth, Boston, MA 02115 USA. [Bulathsinhala, Lakmini; McKinnon, Craig J.; Hill, Owen T.] US Army Res Inst Environm Med, Environm Med Mil Performance Div, Natick, MA 01760 USA. [Bulathsinhala, Lakmini; Hill, Owen T.] Ctr Intrepid, Houston, TX USA. RP Smith, TJ (reprint author), US Army Res Inst Environm Med, Mil Nutr Div, 15 Gen Greene Ave,Bldg 42, Natick, MA 01760 USA. EM tracey.smith10.civ@mail.mil NR 31 TC 1 Z9 1 U1 2 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 EI 1873-2607 J9 AM J PREV MED JI Am. J. Prev. Med. PD JUN PY 2016 VL 50 IS 6 BP E163 EP E171 DI 10.1016/j.amepre.2015.10.015 PG 9 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA DM7CD UT WOS:000376509900001 PM 26699247 ER PT J AU Dimitrova, R Silver, Z Zsedrovits, T Hocut, CM Leo, LS Di Sabatino, S Fernando, HJS AF Dimitrova, Reneta Silver, Zachariah Zsedrovits, Tamas Hocut, Christopher M. Leo, Laura S. Di Sabatino, Silvana Fernando, Harindra J. S. TI Assessment of Planetary Boundary-Layer Schemes in the Weather Research and Forecasting Mesoscale Model Using MATERHORN Field Data SO BOUNDARY-LAYER METEOROLOGY LA English DT Article DE Boundary-layer parametrization; Complex terrain; Stable boundary layer; Turbulence; Weather Research and Forecasting model evaluation ID ATMOSPHERIC SURFACE-LAYER; NONLOCAL CLOSURE-MODEL; WRF MODEL; VERTICAL DIFFUSION; NUMERICAL-SIMULATION; SIMILARITY THEORY; PBL SCHEMES; PART I; SENSITIVITY; TURBULENCE AB The study was aimed at understanding the deficiencies of numerical mesoscale models by comparing predictions with a new high-resolution meteorological dataset collected during the Mountain Terrain Atmospheric Modelling and Observations (MATERHORN) Program. The simulations focussed on the stable boundary layer (SBL), the predictions of which continue to be challenging. High resolution numerical simulations (0.5-km horizontal grid size) were conducted to investigate the efficacy of six planetary boundary-layer (PBL) parametrizations available in the advanced research version of the Weather Research and Forecasting model. One of the commonly used PBL schemes was modified to include eddy diffusivities that account for enhanced momentum transport compared to heat transport in the SBL, representing internal wave dynamics. All of the tested PBL schemes, including the modified scheme, showed a positive surface temperature bias. None of the PBL schemes was found to be superior in predicting the vertical wind and temperature profiles over the lowest 500 m, however two of the schemes appeared superior in capturing the lower PBL structure. The lowest model layers appear to have a significant impact on the predictions aloft. Regions of sporadic flow interactions delineated by the MATERHORN observations were poorly predicted, given such interactions are not represented in typical PBL schemes. C1 [Dimitrova, Reneta; Silver, Zachariah; Zsedrovits, Tamas; Hocut, Christopher M.; Leo, Laura S.; Di Sabatino, Silvana; Fernando, Harindra J. S.] Univ Notre Dame, Civil & Environm Engn & Earth Sci, Notre Dame, IN 46556 USA. [Dimitrova, Reneta] Bulgarian Acad Sci, Dept Geophys, Natl Inst Geophys Geodesy & Geog, Atmospher Phys, BU-1113 Sofia, Bulgaria. [Zsedrovits, Tamas] Pazmany Peter Catholic Univ, Fac Informat Technol & Bion, H-1088 Budapest, Hungary. [Hocut, Christopher M.] US Army, Res Lab, White Sands Missile Range, NM 88022 USA. [Di Sabatino, Silvana] Univ Bologna, Dept Phys & Astron, Bologna, Italy. RP Dimitrova, R (reprint author), Univ Notre Dame, Civil & Environm Engn & Earth Sci, Notre Dame, IN 46556 USA.; Dimitrova, R (reprint author), Bulgarian Acad Sci, Dept Geophys, Natl Inst Geophys Geodesy & Geog, Atmospher Phys, BU-1113 Sofia, Bulgaria. EM Reneta.Dimitrova@nd.edu RI Leo, Laura/J-9529-2013; Zsedrovits, Tamas/D-1362-2016 OI Leo, Laura/0000-0003-4103-6862; Zsedrovits, Tamas/0000-0003-0768-1171 FU US Office of Naval Research Award, Mountain Terrain Atmospheric Modelling and Observations (MATERHORN) Program [N00014-11-1-0709]; European Union; State of Hungary [TAMOP-4.2.1.B-11/2/KMR-2011-0002] FX This research was funded by the US Office of Naval Research Award # N00014-11-1-0709, Mountain Terrain Atmospheric Modelling and Observations (MATERHORN) Program. It has also been supported by the European Union and the State of Hungary in the framework of TAMOP-4.2.1.B-11/2/KMR-2011-0002 Instrument. Additional support was provided by the University of Notre Dame's Centre for Research Computing through computational and storage resources (we specifically acknowledge the assistance of Dodi Heryadi). Furthermore, we are thankful to Jeffrey Massey from the University of Utah for the updated land-cover and soil data. NR 80 TC 1 Z9 1 U1 1 U2 4 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0006-8314 EI 1573-1472 J9 BOUND-LAY METEOROL JI Bound.-Layer Meteor. PD JUN PY 2016 VL 159 IS 3 BP 589 EP 609 DI 10.1007/s10546-015-0095-8 PG 21 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA DM5TG UT WOS:000376412400007 ER PT J AU Jackson, KL Devine, JG AF Jackson, Keith L., II Devine, John G. TI The Effects of Obesity on Spine Surgery: A Systematic Review of the Literature SO GLOBAL SPINE JOURNAL LA English DT Article DE obesity; surgical site infection; lumbar spine; venous thromboembolism ID OUTCOMES-RESEARCH-TRIAL; BODY-MASS INDEX; LOW-BACK-PAIN; INTERVERTEBRAL DISC DEGENERATION; LUMBAR SPINE; RISK-FACTOR; COMPLICATION RATES; HOSPITAL COSTS; TERM OUTCOMES; FUSION AB Study Design Literature review. Objective The aim of this literature review is to examine the effects of obesity on postoperative complications and functional outcomes after spine surgery. Methods A review of the relevant literature examining the effects of obesity and spine surgery was conducted using PubMed, Google Scholar, and Cochrane databases. Results Obesity contributes to disk degeneration and low back pain and potentially increases the risk of developing operative pathology. Obese patients undergoing spine surgery have a higher risk of developing postoperative complications, particularly surgical site infection and venous thromboembolism. Though functional outcomes in this population may not mirror the general population, the treatment effect associated with surgery is at least equivalent if not better in obese individuals. This reduction is primarily due to worse outcomes associated with nonoperative treatment in the obese population. Conclusion Obese individuals represent a unique patient population with respect to nonoperative treatment, postoperative complication rates, and functional outcomes. However, given the equivalent or greater treatment effect of surgery, this comorbidity should not prohibit obese patients from undergoing operative intervention. Future investigations in this area should attempt to develop strategies to minimize complications and improve outcomes in obese individuals and also examine the role of controlled weight loss preoperatively to mitigate these risks. C1 [Jackson, Keith L., II] Womack Army Med Ctr, Dept Orthopaed & Rehabil, 2817 Reilly Rd, Ft Bragg, NC 28310 USA. [Devine, John G.] Georgia Regents Univ, Dept Orthopaed Surg, Augusta, GA USA. RP Jackson, KL (reprint author), Womack Army Med Ctr, Dept Orthopaed & Rehabil, 2817 Reilly Rd, Ft Bragg, NC 28310 USA. EM Lynn.Jackson9@gmail.com NR 55 TC 0 Z9 0 U1 1 U2 1 PU GEORG THIEME VERLAG KG PI STUTTGART PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY SN 2192-5682 EI 2192-5690 J9 GLOB SPINE J JI Glob. Spine J. PD JUN PY 2016 VL 6 IS 4 BP 394 EP 400 DI 10.1055/s-0035-1570750 PG 7 WC Orthopedics SC Orthopedics GA DM8JW UT WOS:000376609600014 PM 27190743 ER PT J AU Lesho, E Chukwuma, U Sparks, M Neumann, C Richesson, D Clifford, R Gierhart, S Waterman, P Hinkle, M AF Lesho, Emil Chukwuma, Uzo Sparks, Michael Neumann, Charlotte Richesson, Douglas Clifford, Robert Gierhart, Sarah Waterman, Paige Hinkle, Mary TI Anatomic, Geographic, and Taxon-Specific Relative Risks of Carbapenem Resistance in the Health Care System of the US Department of Defense SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID ENTEROBACTERIACEAE; INFECTIONS; USAGE; ACINETOBACTER; PATHOGENS; CARRIAGE; PROGRAM AB Carbapenem-resistant Pseudomonas aeruginosa, Acinetobacter spp., and Enterobacteriaceae pose urgent public health threats. The differential burden, relative risks, associations with antimicrobial consumption, and temporal trends of those taxa in large, geographically diverse U.S. health systems remain under reported. Electronic records of all patients in a geographically dispersed 280-hospital managed-care system from 2005 to 2014 were reviewed. Carbapenem-resistant strains were identified based on Clinical and Laboratory Standards Institute guidelines and breakpoints. A total of 360,000 potentially carbapenem-resistant strains were identified from 14.7 million cultures (80% infecting and 20% surveillance). Isolation of bacteria overseas or isolation from the bloodstream was associated with a higher relative risks of carbapenem resistance (CR; P < 0.0001). Enterobacteriaceae were isolated 11 times more frequently than P. aeruginosa and Acinetobacter spp. However, compared to Enterobacteriaceae, the CR levels were 73-fold and 210-fold higher in P. aeruginosa and Acinetobacter spp., respectively. Significant differences in the relative risk of CR between taxa, anatomic, and geographic locations persisted after adjustment for other variables, the biggest differences occurring between taxa. Overall, CR rates increased for Enterobacteriaceae (P = 0.03) and decreased for Acinetobacter spp. and P. aeruginosa (P < 0.0001). These data provide a useful baseline for resistance trending and have implications for surveillance. Infections acquired overseas and bloodstream infections are particularly important areas for continued monitoring. C1 [Lesho, Emil; Sparks, Michael; Clifford, Robert; Hinkle, Mary] Walter Reed Army Inst Res, Antibiot Resistance Monitoring & Res Program, Silver Spring, MD USA. [Chukwuma, Uzo; Neumann, Charlotte; Gierhart, Sarah] Navy & Marine Corps Public Hlth Ctr, EpiData Ctr Dept, Antibiot Resistance Monitoring & Res Program, Portsmouth, VA USA. [Richesson, Douglas] Landstuhl Reg Med Ctr, Antibiot Resistance Monitoring & Res Program, Landstuhl, Germany. [Waterman, Paige] Armed Forces Hlth Surveillance Branch, Global Emerging Infect Surveillance Sect, Silver Spring, MD USA. RP Lesho, E (reprint author), Walter Reed Army Inst Res, Antibiot Resistance Monitoring & Res Program, Silver Spring, MD USA. EM emil.p.lesho.mil@mail.mil FU U.S. Army Medical Command; Armed Forces Health Surveillance Branch FX This work, including the efforts of Emil Lesho, was funded by U.S. Army Medical Command. This work, including the efforts of Emil Lesho, was funded by Armed Forces Health Surveillance Branch. NR 22 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 EI 1098-660X J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JUN PY 2016 VL 54 IS 6 BP 1546 EP 1551 DI 10.1128/JCM.00359-16 PG 6 WC Microbiology SC Microbiology GA DM7HM UT WOS:000376529200021 PM 27030488 ER PT J AU Edwards, MJ Edwards, KD White, C Shepps, C Shackelford, S AF Edwards, Mary J. Edwards, Kurt D. White, Christopher Shepps, Craig Shackelford, Stacy TI Saving the Military Surgeon: Maintaining Critical Clinical Skills in a Changing Military and Medical Environment SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Editorial Material ID HOSPITAL VOLUME; US MILITARY; QUALITY; CARE; EXPERIENCE; OPERATIONS; READINESS; OUTCOMES; CENTERS; CANCER C1 [Edwards, Mary J.; Edwards, Kurt D.; White, Christopher] San Antonio Mil Med Ctr, Dept Surg, San Antonio, TX USA. [Shackelford, Stacy] US Army, Inst Surg Res, Dept Def Joint Trauma Syst, San Antonio, TX USA. [Shepps, Craig] Naval Med Ctr, Dept Surg, Portsmouth, VA USA. RP Edwards, MJ (reprint author), US Army, Dept Surg, San Antonio Mil Med Ctr, 3551 Roger Brooke Dr, San Antonio, TX 78234 USA. EM mary.j.edwards@us.army.mil NR 31 TC 2 Z9 2 U1 1 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 EI 1879-1190 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD JUN PY 2016 VL 222 IS 6 BP 1258 EP 1264 DI 10.1016/j.jamcollsurg.2016.03.031 PG 7 WC Surgery SC Surgery GA DM7DH UT WOS:000376514300044 PM 27185158 ER PT J AU Tian, H Chin, ML Najmaei, S Guo, QS Xia, FN Wang, H Dubey, M AF Tian, He Chin, Matthew L. Najmaei, Sina Guo, Qiushi Xia, Fengnian Wang, Han Dubey, Madan TI Optoelectronic devices based on two-dimensional transition metal dichalcogenides SO NANO RESEARCH LA English DT Review DE transition metal dichalcogenides (TMDCs); optoelectronic device; molybdenum disulfide (MoS2); photodetector; light-emitting diode (LED) ID FIELD-EFFECT TRANSISTORS; SINGLE-LAYER MOS2; MONOLAYER MOLYBDENUM-DISULFIDE; DER-WAALS HETEROSTRUCTURES; LIGHT-EMITTING-DIODES; P-N-JUNCTIONS; BLACK PHOSPHORUS; INPLANE HETEROSTRUCTURES; PHOTOCURRENT GENERATION; GRAPHENE PLASMONICS AB In the past few years, two-dimensional (2D) transition metal dichalcogenide (TMDC) materials have attracted increasing attention of the research community, owing to their unique electronic and optical properties, ranging from the valley-spin coupling to the indirect-to-direct bandgap transition when scaling the materials from multi-layer to monolayer. These properties are appealing for the development of novel electronic and optoelectronic devices with important applications in the broad fields of communication, computation, and healthcare. One of the key features of the TMDC family is the indirect-to-direct bandgap transition that occurs when the material thickness decreases from multilayer to monolayer, which is favorable for many photonic applications. TMDCs have also demonstrated unprecedented flexibility and versatility for constructing a wide range of heterostructures with atomic-level control over their layer thickness that is also free of lattice mismatch issues. As a result, layered TMDCs in combination with other 2D materials have the potential for realizing novel high-performance optoelectronic devices over a broad operating spectral range. In this article, we review the recent progress in the synthesis of 2D TMDCs and optoelectronic devices research. We also discuss the challenges facing the scalable applications of the family of 2D materials and provide our perspective on the opportunities offered by these materials for future generations of nanophotonics technology. C1 [Tian, He; Wang, Han] Univ So Calif, Ming Hsieh Dept Elect Engn, Los Angeles, CA 90089 USA. [Chin, Matthew L.; Najmaei, Sina; Dubey, Madan] US Army Res Lab, Adelphi, MD 20783 USA. [Guo, Qiushi; Xia, Fengnian] Yale Univ, Dept Elect Engn, New Haven, CT 06511 USA. RP Wang, H (reprint author), Univ So Calif, Ming Hsieh Dept Elect Engn, Los Angeles, CA 90089 USA.; Dubey, M (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM han.wang.4@usc.edu; madan.dubey.civ@mail.mil RI Tian, He/I-1299-2014 OI Tian, He/0000-0001-7328-2182 FU National Science Foundation [EFMA-1542815]; Army Research Laboratory; USC Zumberge Individual Award FX The authors acknowledge support from the National Science Foundation (No. EFMA-1542815), Army Research Laboratory, and USC Zumberge Individual Award. NR 122 TC 14 Z9 14 U1 84 U2 220 PU TSINGHUA UNIV PRESS PI BEIJING PA TSINGHUA UNIV, RM A703, XUEYAN BLDG, BEIJING, 10084, PEOPLES R CHINA SN 1998-0124 EI 1998-0000 J9 NANO RES JI Nano Res. PD JUN PY 2016 VL 9 IS 6 BP 1543 EP 1560 DI 10.1007/s12274-016-1034-9 PG 18 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA DM8ZF UT WOS:000376652300001 ER PT J AU Zhao, XG Zhang, JD Fan, KB Duan, GW Metcalfe, GD Wraback, M Zhang, X Averitt, RD AF Zhao, Xiaoguang Zhang, Jingdi Fan, Kebin Duan, Guangwu Metcalfe, Grace D. Wraback, Michael Zhang, Xin Averitt, Richard D. TI Nonlinear terahertz metamaterial perfect absorbers using GaAs [Invited] SO PHOTONICS RESEARCH LA English DT Article ID FIELD; IONIZATION; PULSE AB We investigate the nonlinear response of terahertz (THz) metamaterial perfect absorbers consisting of electric split ring resonators on GaAs integrated with a polyimide spacer and gold ground plane. These perfect absorbers on bulk semi-insulating GaAs are characterized using high-field THz time-domain spectroscopy. The resonance frequency redshifts 20 GHz and the absorbance is reduced by 30% as the incident peak field is increased from 30 to 300 kV/cm. The nonlinear response arises from THz field driven interband transitions and intervalley scattering in the GaAs. To eliminate the Fresnel losses from the GaAs substrate, we design and fabricate a flexible metamaterial saturable perfect absorber. The ability to create nonlinear absorbers enables appealing applications such as optical limiting and self-focusing. (C) 2016 Chinese Laser Press C1 [Zhao, Xiaoguang; Fan, Kebin; Duan, Guangwu; Zhang, Xin] Boston Univ, Dept Mech Engn, 110 Cummington Mall, Boston, MA 02215 USA. [Zhang, Jingdi; Averitt, Richard D.] Univ Calif San Diego, Dept Phys, 9500 Gilman Dr, La Jolla, CA 92093 USA. [Metcalfe, Grace D.; Wraback, Michael] Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RP Zhang, X (reprint author), Boston Univ, Dept Mech Engn, 110 Cummington Mall, Boston, MA 02215 USA. EM xinz@bu.edu; raveritt@ucsd.edu RI Fan, Kebin/B-2984-2012; Zhang, Xin/B-9244-2009 OI Fan, Kebin/0000-0002-0275-0871; Zhang, Xin/0000-0002-4413-5084 FU National Science Foundation [ECCS 1309835]; DOE-Basic Energy Sciences [DE-SC0012592] FX This work was supported in part by the National Science Foundation under contract ECCS 1309835, and the DOE-Basic Energy Sciences under Grant No. DE-SC0012592. The authors would like to thank the Boston University Photonics Center for technical support. NR 34 TC 0 Z9 0 U1 14 U2 32 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 2327-9125 J9 PHOTONICS RES JI Photonics Res. PD JUN 1 PY 2016 VL 4 IS 3 BP A16 EP A21 DI 10.1364/PRJ.4.000A16 PG 6 WC Optics SC Optics GA DM9BJ UT WOS:000376658500003 ER PT J AU Fatichi, S Vivoni, ER Ogden, FL Ivanov, VY Mirus, B Gochis, D Downer, CW Camporese, M Davison, JH Ebel, BA Jones, N Kim, J Mascaro, G Niswonger, R Restrepo, P Rigon, R Shen, C Sulis, M Tarboton, D AF Fatichi, Simone Vivoni, Enrique R. Ogden, Fred L. Ivanov, Valeriy Y. Mirus, Benjamin Gochis, David Downer, Charles W. Camporese, Matteo Davison, Jason H. Ebel, Brian A. Jones, Norm Kim, Jongho Mascaro, Giuseppe Niswonger, Richard Restrepo, Pedro Rigon, Riccardo Shen, Chaopeng Sulis, Mauro Tarboton, David TI An overview of current applications, challenges, and future trends in distributed process-based models in hydrology SO JOURNAL OF HYDROLOGY LA English DT Review DE Modeling; Interdisciplinary; Watershed processes; Virtual experiments; Change assessments; Natural and built environment ID ATMOSPHERIC BOUNDARY-LAYER; VARIABLY SATURATED FLOW; SURFACE PROCESSES MODEL; EARTH SYSTEM MODELS; LAND-SURFACE; CATCHMENT-SCALE; SOIL-MOISTURE; CLIMATE-CHANGE; DATA ASSIMILATION; RESPONSE SIMULATION AB Process-based hydrological models have a long history dating back to the 1960s. Criticized by some as over-parameterized, overly complex, and difficult to use, a more nuanced view is that these tools are necessary in many situations and, in a certain class of problems, they are the most appropriate type of hydrological model. This is especially the case in situations where knowledge of flow paths or distributed state variables and/or preservation of physical constraints is important. Examples of this include: spatiotemporal variability of soil moisture, groundwater flow and runoff generation, sediment and contaminant transport, or when feedbacks among various Earth's system processes or understanding the impacts of climate non-stationarity are of primary concern. These are situations where process-based models excel and other models are unverifiable. This article presents this pragmatic view in the context of existing literature to justify the approach where applicable and necessary. We review how improvements in data availability, computational resources and algorithms have made detailed hydrological simulations a reality. Avenues for the future of process-based hydrological models are presented suggesting their use as virtual laboratories, for design purposes, and with a powerful treatment of uncertainty. (C) 2016 Elsevier B.V. All rights reserved. C1 [Fatichi, Simone] ETH, Inst Environm Engn, Stefano Franscini Pl 5,HIL D 23-2, CH-8093 Zurich, Switzerland. [Vivoni, Enrique R.] Arizona State Univ, Sch Earth & Space Explorat, Tempe, AZ USA. [Vivoni, Enrique R.] Arizona State Univ, Sch Sustainable Engn & Built Environm, Tempe, AZ USA. [Ogden, Fred L.] Univ Wyoming, Dept Civil & Architectural Engn, Laramie, WY 82071 USA. [Ivanov, Valeriy Y.; Kim, Jongho] Univ Michigan, Dept Civil & Environm Engn, Ann Arbor, MI 48109 USA. [Mirus, Benjamin] US Geol Survey, Geol Hazards Sci Ctr, Golden, CO USA. [Gochis, David] Natl Ctr Atmospher Res, POB 3000, Boulder, CO 80307 USA. [Downer, Charles W.] Engn Res & Dev Ctr, Hydrol Syst Branch, Coastal & Hydraul Lab, Vicksburg, MS USA. [Camporese, Matteo] Univ Padua, Dept Civil Environm & Architectural Engn, Padua, Italy. [Davison, Jason H.] Univ Waterloo, Dept Earth & Environm Sci, Waterloo, ON N2L 3G1, Canada. [Ebel, Brian A.] US Geol Survey, Natl Res Program, Box 25046, Denver, CO 80225 USA. [Jones, Norm] Brigham Young Univ, Provo, UT 84602 USA. [Kim, Jongho] Sejong Univ, Dept Civil & Environm Engn, Seoul, South Korea. [Mascaro, Giuseppe] Arizona State Univ, Julie Anne Wrigley Global Inst Sustainabil, Tempe, AZ USA. [Niswonger, Richard] US Geol Survey, Natl Res Program, 345 Middlefield Rd, Menlo Pk, CA 94025 USA. [Restrepo, Pedro] NOAA, North Cent River Forecast Ctr, Natl Weather Serv, Chanhassen, MN USA. [Rigon, Riccardo] Univ Trento, Dipartimen Ingn Civile Ambientale & Meccan, Trento, Italy. [Rigon, Riccardo] Univ Trento, CUDAM, Trento, Italy. [Shen, Chaopeng] Penn State Univ, Dept Civil & Environm Engn, University Pk, PA 16802 USA. [Sulis, Mauro] Univ Bonn, Meteorol Inst, Bonn, Germany. [Tarboton, David] Utah State Univ, Civil & Environm Engn, Logan, UT 84322 USA. RP Fatichi, S (reprint author), ETH, Inst Environm Engn, Stefano Franscini Pl 5,HIL D 23-2, CH-8093 Zurich, Switzerland. EM simone.fatichi@ifu.baug.ethz.ch RI Vivoni, Enrique/E-1202-2012; Camporese, Matteo/I-5405-2012; Mascaro, Giuseppe/K-5504-2013; Rigon, Riccardo/B-5395-2008; OI Vivoni, Enrique/0000-0002-2659-9459; Camporese, Matteo/0000-0002-7505-798X; Mascaro, Giuseppe/0000-0003-4516-1206; Rigon, Riccardo/0000-0002-7668-5806; Ebel, Brian/0000-0002-5413-3963; Fatichi, Simone/0000-0003-1361-6659 FU Stavros Niarchos Foundation; ETH Zurich Foundation [ETH-29 14-2]; NSF [EAR 1151443]; Deutsche Forschungsgemeinschaft (DFG) [SFB/TR32] FX This article resulted from discussions held during the session "High Resolution Hydrologic Modeling: Challenges and Avenues for Development" at the American Geophysical Union Fall Meeting 2013 in San Francisco, USA. Luke McGuire, USGS, provided a useful review of an earlier draft of this manuscript. We thank Massimo Dotti for the references about astrophysics. SF thanks the support of the Stavros Niarchos Foundation and the ETH Zurich Foundation (Grant ETH-29 14-2). VI acknowledges the support of NSF Grant EAR 1151443. MS acknowledges financial support from SFB/TR32 (Patterns in Soil-Vegetation-Atmosphere Systems: Monitoring, Modeling, and Data Assimilation) funded by the Deutsche Forschungsgemeinschaft (DFG). Any use of trade, firm, or product names is for descriptive purposes only and does not imply endorsement by the U.S. Government. NR 290 TC 13 Z9 13 U1 65 U2 115 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-1694 EI 1879-2707 J9 J HYDROL JI J. Hydrol. PD JUN PY 2016 VL 537 BP 45 EP 60 DI 10.1016/j.jhydrol.2016.03.026 PG 16 WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA DM2XU UT WOS:000376212200007 ER PT J AU Boucher, R Kang, W Gong, Q AF Boucher, Randy Kang, Wei Gong, Qi TI Galerkin Optimal Control SO JOURNAL OF OPTIMIZATION THEORY AND APPLICATIONS LA English DT Article DE Optimal control; Constrained optimization; Pseudospectral; Galerkin ID FEEDBACK LINEARIZABLE SYSTEMS; FINITE-ELEMENT DISCRETIZATION; PSEUDOSPECTRAL METHODS; CONTROL CONSTRAINTS; CONVERGENCE; EQUATIONS AB This paper introduces a family of computational methods for solving optimal control problems that calculate optimal trajectories using Galerkin numerical techniques. An important result in the theoretical foundation of these methods is that their associated feasibility and consistency theorems are proved for problems with continuous and/or piecewise continuous controls. In this paper we demonstrate that Galerkin numerical techniques allow for the formulation of optimal control problems in a number of ways that allow for efficiency and/or improved accuracy. The family of Galerkin methods presented can solve a wide range of optimal control problems with a variety of state and control constraints. Numerical formulations using Lagrangian and Legendre test functions are derived. Finally, numerical examples demonstrate the versatile nature of various Galerkin optimal control formulations. C1 [Boucher, Randy] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. [Kang, Wei] Naval Postgrad Sch, Dept Appl Math, Monterey, CA USA. [Gong, Qi] Univ Calif Santa Cruz, Dept Appl Math & Stat, Santa Cruz, CA 95064 USA. RP Kang, W (reprint author), Naval Postgrad Sch, Dept Appl Math, Monterey, CA USA. EM randy.boucher@usma.edu; wkang@nps.edu; qigong@soe.ucsc.edu FU Air Force Office of Scientific Research (AFOSR); Naval Research Laboratory (NRL) FX This work was supported in part by the Air Force Office of Scientific Research (AFOSR) and the Naval Research Laboratory (NRL). The work and views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of the Army, the Department of the Navy, the Department of Defense, or the U.S. Government. NR 28 TC 0 Z9 0 U1 0 U2 2 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0022-3239 EI 1573-2878 J9 J OPTIMIZ THEORY APP JI J. Optim. Theory Appl. PD JUN PY 2016 VL 169 IS 3 BP 825 EP 847 DI 10.1007/s10957-016-0918-x PG 23 WC Operations Research & Management Science; Mathematics, Applied SC Operations Research & Management Science; Mathematics GA DM4CS UT WOS:000376293800007 ER PT J AU Morgan, AB Yip, PW AF Morgan, Alexander B. Yip, Pearl W. TI Effects of laundering on military uniform fabric flammability SO FIRE AND MATERIALS LA English DT Article DE textiles; flame spread testing; pyrolysis GC-MS; cone calorimeter; pyrolysis combustion flow calorimetry ID TEXTILES; CALORIMETRY AB In this paper, the effects of laundering on the flammability of a military uniform fabric were studied. The flame retardant was incorporated into the fiber prior to fiber spinning, and its ability to maintain flame spread and flame retardancy was evaluated by multiple test methods. Vertical flame spread, cone calorimeter, and pyrolysis combustion flow calorimetry were used to determine how many of the flame retardants were removed as a function of wash cycles and if there was any measurable reduction in heat release/fire safety performance that correlated with a loss in flame retardant from washing. Fire testing showed that flame spread performance was maintained within the normal error for the measurement and heat release testing showed very little difference between samples as a function of laundering. Additional analysis via pyrolysis gas chromatography-mass spectrometry showed that while the flame retardant levels did decrease with washing, enough of the material remained embedded in the fibers so that fire performance could be maintained. The results do indicate that the flame retardant can be washed off, but because of the flame retardant being deeply embedded in the fiber, enough will remain with the fabric after 25 washes to maintain flame retardant performance. Copyright (c) 2015 John Wiley & Sons, Ltd. C1 [Morgan, Alexander B.] Univ Dayton, Res Inst, Energy Technol & Mat Div, 300 Coll Pk, Dayton, OH 45469 USA. [Yip, Pearl W.] US Army, Natick Soldier Res Dev & Engn Ctr, Mol Sci & Engn Team, Natick, MA 01760 USA. RP Morgan, AB (reprint author), Univ Dayton, Res Inst, Energy Technol & Mat Div, 300 Coll Pk, Dayton, OH 45469 USA. EM alexander.morgan@udri.udayton.edu FU US Army [W6QK ACC-14-P-0043] FX The authors would like to thank Wayne Muller and Margaret Auerbach of NSRDEC for their guidance and assistance in the Vertical Flame Test measurements. Special thanks also go to Celia Powell of NSRDEC for sharing her materials, expertise, and experimental data. The authors also wish to thank Mary Galaska, Becki Glagola, and Kathy Schenck of UDRI for their assistance with PCFC and cone calorimeter testing. Funding for this work was provided under US Army contract number W6QK ACC-14-P-0043. NR 17 TC 0 Z9 0 U1 6 U2 10 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0308-0501 EI 1099-1018 J9 FIRE MATER JI Fire Mater. PD JUN PY 2016 VL 40 IS 4 BP 599 EP 611 DI 10.1002/fam.2313 PG 13 WC Materials Science, Multidisciplinary SC Materials Science GA DJ8WM UT WOS:000374494100007 ER PT J AU Kessens, CC Desai, JP AF Kessens, Chad C. Desai, Jaydev P. TI Versatile Passive Grasping for Manipulation SO IEEE-ASME TRANSACTIONS ON MECHATRONICS LA English DT Article DE Grasping; manipulation; shape memory alloy; suction; unknown object ID ACTUATOR; DRIVEN; ROBOT; HAND AB As a robot's tasks become increasingly diverse, an end-effector's ability to grasp the widest possible range of object shapes and sizes will be paramount. In previous work, we demonstrated the potential of our patented self-sealing suction cup technology to expand upon the traditional grasping techniques. In this paper, we improve upon the original design by making it smaller and more robust, develop a new compact, SMA-actuated three-finger hand utilizing these cups, and introduce a release system. We then characterize the cup performance showing a self-seal quality, leak rate, object seal and reseal quality, life cycle performance, normal force-displacement response, and shear force response. Finally, we characterize the hand performance showing a range of motion, force, and grasp and release of several objects using the new three-finger hand attached to a PA-10 robot manipulator. C1 [Kessens, Chad C.; Desai, Jaydev P.] Univ Maryland, Dept Mech Engn, Robot Automat & Med Syst Lab, College Pk, MD 20740 USA. [Kessens, Chad C.] US Army, Res Lab, Adelphi, MD 20783 USA. RP Kessens, CC; Desai, JP (reprint author), Univ Maryland, Dept Mech Engn, Robot Automat & Med Syst Lab, College Pk, MD 20740 USA.; Kessens, CC (reprint author), US Army, Res Lab, Adelphi, MD 20783 USA. EM ckessens@umd.edu; jaydev@umd.edu NR 30 TC 0 Z9 0 U1 4 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1083-4435 EI 1941-014X J9 IEEE-ASME T MECH JI IEEE-ASME Trans. Mechatron. PD JUN PY 2016 VL 21 IS 3 BP 1293 EP 1302 DI 10.1109/TMECH.2016.2520306 PG 10 WC Automation & Control Systems; Engineering, Manufacturing; Engineering, Electrical & Electronic; Engineering, Mechanical SC Automation & Control Systems; Engineering GA DL4MC UT WOS:000375609900010 ER PT J AU Habtour, E Cole, DP Stanton, SC Sridharan, R Dasgupta, A AF Habtour, Ed Cole, Daniel P. Stanton, Samuel C. Sridharan, Raman Dasgupta, Abhijit TI Damage precursor detection for structures subjected to rotational base vibration SO INTERNATIONAL JOURNAL OF NON-LINEAR MECHANICS LA English DT Article DE Damage precursor; fatigue; nonlinear vibration; damage detection; gyroscopic ID CANTILEVER BEAM; TORSIONAL DYNAMICS; FLEXIBLE BEAMS; MODULUS; NANOINDENTATION; HARVESTERS; BEHAVIOR; HARDNESS; MOTION; STEEL AB This paper presents a nonlinear dynamic methodology for monitoring precursors of fatigue damage in metallic structures under variable rotational base excitation. The methodology accounts for important nonlinearities due to the complex loading generated by variable rotation and structural degradation. The sources of the nonlinearities include: structural stiffening due to gyroscopic motion and high-response amplitude at the fundamental mode, softening due to inertial forces and gyroscopic loads, and localized microscopic material damage and micro-plasticity. The loading intensity and number of vibration cycles increase the influence of these effects. The change in the dynamic response due to fatigue damage accumulation is experimentally investigated by exciting a cantilever beam at variable rotational base motions. The observed fatigue evolution in the material microstructure at regions of large stresses (and the resulting progressive structural softening) is tracked by quantifying the growth in the tip response, the change in the fundamental natural frequency of the beam and the skewedness of the stepped-sine response curve. Previous understanding of the structural dynamic behavior is necessary to ascertain the damage precursor location and evolution. Nanoindentation studies near the beam clamped boundary are conducted to confirm the gradual progression in the local mechanical properties as a function of loading cycles, and microstructural studies are conducted to obtain qualitative preliminary insights into the microstructure evolution. This study demonstrates that careful monitoring of the nonlinearities in the structural dynamic response can be a sensitive parameter for detection of damage precursors. Published by Elsevier Ltd. C1 [Habtour, Ed; Cole, Daniel P.] Vehicle Technol Directorate, US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Stanton, Samuel C.] US Army Res Off, Mech Sci, Aberdeen Proving Ground, MD 21005 USA. [Sridharan, Raman; Dasgupta, Abhijit] Univ Maryland, Ctr Adv Life Cycle Engn, College Pk, MD 20742 USA. RP Habtour, E (reprint author), Vehicle Technol Directorate, US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM ed.m.habtour.civ@mail.mil OI Habtour, Ed/0000-0002-9083-9285 FU Center for Advanced Life Cycle Engineering (CALCE) at the University of Maryland; U.S. Army Research Laboratory (ARL); University of Maryland under ARL Open-Campus Initiative FX This research effort was funded by the sponsors of the Center for Advanced Life Cycle Engineering (CALCE) at the University of Maryland and was further supported by a Collaborative Research and Development Agreement (CRADA) between the U.S. Army Research Laboratory (ARL) and the University of Maryland under ARL Open-Campus Initiative. NR 54 TC 1 Z9 1 U1 2 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0020-7462 EI 1878-5638 J9 INT J NONLIN MECH JI Int. J. Non-Linear Mech. PD JUN PY 2016 VL 82 BP 49 EP 58 DI 10.1016/j.ijnonlinmec.2016.02.009 PG 10 WC Mechanics SC Mechanics GA DL7KF UT WOS:000375818900006 ER PT J AU Kasantikul, T Visessripong, A Chatrungreungkul, S Lombardini, ED Sirimanapong, W AF Kasantikul, T. Visessripong, A. Chatrungreungkul, S. Lombardini, E. D. Sirimanapong, W. TI Suspected thymic lymphoma with invasion of the gills in a gold crossback arowana (Scleropages formosus) SO JOURNAL OF FISH DISEASES LA English DT Article DE crossback arowana; neoplasm; Scleropages formosus; thymic lymphoma ID MEDAKA ORYZIAS-LATIPES; LYMPHOBLASTIC LYMPHOMA; CHANNEL CATFISH; LYMPHOSARCOMA; TROUT; FISH C1 [Kasantikul, T.; Chatrungreungkul, S.] Mahidol Univ, Fac Vet Sci, Ctr Vet Diag, Salaya, Nakhon Pathom, Thailand. [Visessripong, A.; Sirimanapong, W.] Mahidol Univ, Fac Vet Sci, Dept Clin Sci & Publ Hlth, 999 Phutthamonthon Sai 4 Rd, Salaya 73170, Nakhon Pathom, Thailand. [Lombardini, E. D.] Armed Forces Res Inst Med Sci, Dept Vet Med, Div Comparat Pathol, Bangkok 10400, Thailand. [Lombardini, E. D.] Armed Forces Res Inst Med Sci, Dept Vet Med, Div Vet Med Res, Bangkok 10400, Thailand. RP Sirimanapong, W (reprint author), Mahidol Univ, Fac Vet Sci, Dept Clin Sci & Publ Hlth, 999 Phutthamonthon Sai 4 Rd, Salaya 73170, Nakhon Pathom, Thailand. EM wanna.sir@mahidol.ac.th NR 21 TC 0 Z9 0 U1 0 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0140-7775 EI 1365-2761 J9 J FISH DIS JI J. Fish Dis. PD JUN PY 2016 VL 39 IS 6 BP 783 EP 786 DI 10.1111/jfd.12424 PG 4 WC Fisheries; Marine & Freshwater Biology; Veterinary Sciences SC Fisheries; Marine & Freshwater Biology; Veterinary Sciences GA DL6XO UT WOS:000375783600016 PM 26596259 ER PT J AU Oliveira, AS Schlink, BR Hairston, WD Konig, P Ferris, DP AF Oliveira, Anderson S. Schlink, Bryan R. Hairston, W. David Koenig, Peter Ferris, Daniel P. TI Induction and separation of motion artifacts in EEG data using a mobile phantom head device SO JOURNAL OF NEURAL ENGINEERING LA English DT Article DE EEG; motion artifacts; ICA; signal-to-noise ratio; phantom head; walking; locomotion ID VISUAL-EVOKED RESPONSES; HUMAN SKULL PHANTOM; SOURCE LOCALIZATION; TREADMILL WALKING; BRAIN; ELECTROENCEPHALOGRAM; ACCELERATIONS; DYNAMICS; HUMANS AB Objective. Electroencephalography (EEG) can assess brain activity during whole-body motion in humans but head motion can induce artifacts that obfuscate electrocortical signals. Definitive solutions for removing motion artifact from EEG have yet to be found, so creating methods to assess signal processing routines for removing motion artifact are needed. We present a novel method for investigating the influence of head motion on EEG recordings as well as for assessing the efficacy of signal processing approaches intended to remove motion artifact. Approach. We used a phantom head device to mimic electrical properties of the human head with three controlled dipolar sources of electrical activity embedded in the phantom. We induced sinusoidal vertical motions on the phantom head using a custom-built platform and recorded EEG signals with three different acquisition systems while the head was both stationary and in varied motion conditions. Main results. Recordings showed up to 80% reductions in signal-to-noise ratio (SNR) and up to 3600% increases in the power spectrum as a function of motion amplitude and frequency. Independent component analysis (ICA) successfully isolated the three dipolar sources across all conditions and systems. There was a high correlation (r >. 0.85) and marginal increase in the independent components' (ICs) power spectrum (similar to 15%) when comparing stationary and motion parameters. The SNR of the IC activation was 400%-700% higher in comparison to the channel data SNR, attenuating the effects of motion on SNR. Significance. Our results suggest that the phantom head and motion platform can be used to assess motion artifact removal algorithms and compare different EEG systems for motion artifact sensitivity. In addition, ICA is effective in isolating target electrocortical events and marginally improving SNR in relation to stationary recordings. C1 [Oliveira, Anderson S.; Schlink, Bryan R.; Ferris, Daniel P.] Univ Michigan, Sch Kinesiol, Human Neuromech Lab, Ann Arbor, MI 48109 USA. [Hairston, W. David] US Army Res Lab, Aberdeen Proving Ground, MD USA. [Koenig, Peter] Univ Osnabruck, Osnabruck, Germany. [Koenig, Peter] Univ Med Ctr Hamburg Eppendorf, Hamburg, Germany. RP Oliveira, AS (reprint author), Univ Michigan, Sch Kinesiol, Human Neuromech Lab, Ann Arbor, MI 48109 USA. EM oliveira_dkbr@hotmail.com OI Oliveira, Anderson/0000-0003-2186-8100 FU Cognition and Neuroergonomics Collaborative Technology Alliance [ARL W911NF-10-2-0022] FX Research supported by the Cognition and Neuroergonomics Collaborative Technology Alliance ARL W911NF-10-2-0022. NR 31 TC 0 Z9 0 U1 2 U2 3 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 1741-2560 EI 1741-2552 J9 J NEURAL ENG JI J. Neural Eng. PD JUN PY 2016 VL 13 IS 3 AR 036014 DI 10.1088/1741-2560/13/3/036014 PG 14 WC Engineering, Biomedical; Neurosciences SC Engineering; Neurosciences & Neurology GA DL5TZ UT WOS:000375701200018 PM 27137818 ER PT J AU Esposito, ER Whitehead, JMA Wilken, JM AF Esposito, Elizabeth Russell Whitehead, Jennifer M. Aldridge Wilken, Jason M. TI Step-to-step transition work during level and inclined walking using passive and powered ankle-foot prostheses SO PROSTHETICS AND ORTHOTICS INTERNATIONAL LA English DT Article DE Energetics; transtibial; hill; biomechanics ID BELOW-KNEE AMPUTEES; MECHANICAL WORK; TRANSTIBIAL AMPUTATION; ENERGETIC CONSEQUENCES; BIOMECHANICAL ANALYSIS; DOWNHILL WALKING; GAIT; FEET; AMBULATION; EXPENDITURE AB Background: Individuals with leg amputations who use passive prostheses have greater metabolic demands than non-amputees likely due to limited net positive work compared to a biological ankle. New powered ankle-foot prostheses can perform net positive mechanical work to aid push-off capabilities, which may reduce metabolic demands. Objectives: Compare step-to-step transition work and metabolic demand during level and inclined walking using passive and powered ankle-foot prostheses. Study Design: Repeated measures. Methods: Six individuals with transtibial amputation and six able-bodied controls walked at a standardized speed across level ground and up a 5 degrees incline. Calculated measures included mechanical work during step-to-step transitions from the trailing prosthetic to leading intact limb, steady state metabolic rate, and ankle joint kinetics and kinematics. Results: The powered prosthesis generated 63% greater trailing limb step-to-step transition work than the passive during level walking only (p=0.004). Metabolic rate was lower with the powered prosthesis during level (p=0.006) but not inclined walking (p=0.281). The powered prosthesis increased ankle power compared to the passive, to the extent that power was normalized to controls during inclined walking and greater than controls during level walking. Conclusion: The powered prosthesis improved ankle power, metabolic rate, and step-to-step transition work on level ground, with few negative consequences on inclines. These results may be used to guide the development and use of actively powered prosthetic devices in high-functioning individuals. Clinical relevance Overall, powered devices offer biomechanical and metabolic benefits over passive energy storage and return designs on level ground and perform as well as a passive model on inclines. The lower metabolic demand when using the powered device may delay fatigue for individuals with transtibial amputation when walking over level ground. C1 [Esposito, Elizabeth Russell; Whitehead, Jennifer M. Aldridge; Wilken, Jason M.] Brooke Army Med Ctr, Ctr Intrepid, 3551 Roger Brooke Dr, Houston, TX 78234 USA. RP Esposito, ER (reprint author), Brooke Army Med Ctr, Ctr Intrepid, 3551 Roger Brooke Dr, Houston, TX 78234 USA. EM erussell.kin@gmail.com FU Center for Rehabilitation Sciences Research (CRSR), Department of Physical Medicine and Rehabilitation, Uniformed Services University of Health Sciences, Bethesda, MD; US Army Telemedicine & Advanced Technology Research Center (TATRC) FX Support was provided by the Center for Rehabilitation Sciences Research (CRSR), Department of Physical Medicine and Rehabilitation, Uniformed Services University of Health Sciences, Bethesda, MD, and US Army Telemedicine & Advanced Technology Research Center (TATRC). NR 34 TC 2 Z9 2 U1 5 U2 11 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0309-3646 EI 1746-1553 J9 PROSTHET ORTHOT INT JI Prosthet. Orthot. Int. PD JUN PY 2016 VL 40 IS 3 BP 311 EP 319 DI 10.1177/0309364614564021 PG 9 WC Orthopedics; Rehabilitation SC Orthopedics; Rehabilitation GA DL5TD UT WOS:000375698900003 ER PT J AU Khamkanya, A Cho, BR Goethals, PL AF Khamkanya, Anintaya Cho, Byung Rae Goethals, Paul L. TI Integrating Customer Perception into Process Capability Measures SO QUALITY AND RELIABILITY ENGINEERING INTERNATIONAL LA English DT Article DE process capability; customer-perceived capability indices; truncated normal distribution; Johnson transformation ID NORMAL-DISTRIBUTIONS; NONNORMAL DATA; INDEXES; OPTIMIZATION AB Process capability indices provide a measure of the output of an in-control process that conforms to a set of specification limits. These measures, which assume that process output is approximately normally distributed, are intended for measuring process capability for manufacturing systems. When the performance of a system results in a product that fails to fall within a given specification range, however, the product is typically scrapped or reworked, and the actual distribution that the customer perceives after inspection is truncated. In this paper, the concept of a truncated measure for three types of quality characteristics is introduced as the key to linking customer perception to process capability. Subsequently, a set of customer-perceived process capability indices is presented as an extension of traditional manufacturer-based counterparts. Finally, data transformation-based process capability indices are also discussed. A comparative study and numerical example reveal considerable differences among the traditional and proposed process capability indices. It is believed that the proposed process capability index for various quality characteristics may more aptly lead to process improvement by facilitating a better understanding of the integrated effects found in engineering design problems. Copyright (c) 2015 John Wiley & Sons, Ltd. C1 [Khamkanya, Anintaya; Cho, Byung Rae] Clemson Univ, Dept Ind Engn, Clemson, SC USA. [Goethals, Paul L.] US Mil Acad, West Point, NY 10996 USA. RP Goethals, PL (reprint author), US Mil Acad, West Point, NY 10996 USA. EM paul.goethals@yahoo.com NR 36 TC 0 Z9 0 U1 1 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0748-8017 EI 1099-1638 J9 QUAL RELIAB ENG INT JI Qual. Reliab. Eng. Int. PD JUN PY 2016 VL 32 IS 4 BP 1331 EP 1345 DI 10.1002/qre.1833 PG 15 WC Engineering, Multidisciplinary; Engineering, Industrial; Operations Research & Management Science SC Engineering; Operations Research & Management Science GA DK1OB UT WOS:000374681200006 ER PT J AU Beck, R Zhan, SG Liu, HX Tong, S Yang, B Xu, M Ye, ZX Huang, Y Shu, S Wu, QS Wang, SJ Berling, K Murray, A Emery, E Reif, M Harwood, J Young, J Nietch, C Macke, D Martin, M Stillings, G Stump, R Su, HB AF Beck, Richard Zhan, Shengan Liu, Hongxing Tong, Susanna Yang, Bo Xu, Min Ye, Zhaoxia Huang, Yan Shu, Song Wu, Qiusheng Wang, Shujie Berling, Kevin Murray, Andrew Emery, Erich Reif, Molly Harwood, Joseph Young, Jade Nietch, Christopher Macke, Dana Martin, Mark Stillings, Garrett Stump, Richard Su, Haibin TI Comparison of satellite reflectance algorithms for estimating chlorophyll-a in a temperate reservoir using coincident hyperspectral aircraft imagery and dense coincident surface observations SO REMOTE SENSING OF ENVIRONMENT LA English DT Article DE Chlorophyll-a; Algal bloom; Harmful algal bloom; Algorithm; Satellite; Hyperspectral; Multispectral ID TURBID PRODUCTIVE WATERS; REMOTE-SENSING METHODS; THEMATIC MAPPER DATA; SPECTRAL REFLECTANCE; ALGAL CHLOROPHYLL; INLAND WATERS; OCEAN COLOR; 700 NM; QUALITY; LAKE AB We compared 10 established and 2 new satellite reflectance algorithms for estimating chlorophyll-a (Chl-a) in a temperate reservoir in southwest Ohio using coincident hyperspectral aircraft imagery and dense coincident surface observations collected within 1 h of image acquisition to develop simple proxies for algal blooms in water bodies sensitive to algal blooms (especially toxic or harmful algal blooms (HABs)) and to facilitate portability between multispectral satellite imagers for regional algal bloom monitoring. All algorithms were compared with narrow band hyperspectral aircraft images. These images were subsequently upscaled spectrally and spatially to simulate 5 current and near future satellite imaging systems. Established and new Chl-a algorithms were then applied to the synthetic satellite images and compared to coincident surface observations of Chl-a collected from 44 sites within 1 h of aircraft acquisition of the imagery. We found several promising algorithm/satellite imager combinations for routine Chl-a estimation in smaller inland water bodies with operational and near-future satellite systems. The CI, MCI, FLH, NDCI, 2BDA and 3 BDA Chl-a algorithms worked well with CASI imagery. The NDCI, 2BDA, and 3BDA Chl-a algorithms worked well with simulated WorldView-2 and 3, Sentinel-2, and MERIS-like imagery. NDCI was the most widely applicable Chl-a algorithm with good performance for CASI, WorldView 2 and 3, Sentinel-2 and MERIS-like imagery and limited performance with MODIS imagery. A new fluorescence line height "greenness" algorithm yielded the best Chl-a estimates with simulated Landsat-8 imagery. (C) 2016 Elsevier Inc. All rights reserved. C1 [Beck, Richard; Zhan, Shengan; Liu, Hongxing; Tong, Susanna; Yang, Bo; Xu, Min; Ye, Zhaoxia; Huang, Yan; Shu, Song; Wu, Qiusheng; Wang, Shujie; Berling, Kevin; Murray, Andrew] Univ Cincinnati, Dept Geog, Cincinnati, OH 45221 USA. [Emery, Erich] US Army, Corps Engineers, Great Lakes & Ohio River Div, Cincinnati, OH 45202 USA. [Reif, Molly; Harwood, Joseph] US Army, Corps Engineers, Erdc, JALBTCX, Kiln, MS 39556 USA. [Young, Jade] US Army, Corps Engineers, Water Qual, Louisville, KY 40202 USA. [Nietch, Christopher; Macke, Dana] US EPA, Cincinnati, OH 45268 USA. [Martin, Mark; Stillings, Garrett; Stump, Richard] Kentucky Dept Environm Protect, Div Water, Frankfort, KY 40601 USA. NOAA, Natl Ocean Serv, Silver Spring, MD USA. [Su, Haibin] Texas A&M Kingsville, Dept Phys & Geosci, Kingsville, TX 78363 USA. RP Beck, R (reprint author), Univ Cincinnati, Dept Geog, Cincinnati, OH 45221 USA. EM richard.beck@uc.edu; zhansn@mail.uc.edu; hongxing.liu@uc.edu; susana.tong@uc.edu; yangb2@mail.uc.edu; xum4@mail.uc.edu; yeza@ucmail.uc.edu; huang2y2@ucmail.uc.edu; shusg@mail.uc.edu; wuqe@mail.uc.edu; wang2sj@mail.uc.edu; berlinkj@mail.uc.edu; murraya2@mail.uc.edu; erich.b.emery@usace.army.mil; molly.k.reif@usace.army.mil; joseph.h.harwood@usace.army.mil; jade.l.young@usace.army.mil; nietch.christopher@epa.gov; macke.dana@epa.gov; mark.martin@ky.gov; garrett.stillings@ky.gov; richard.stumpf@noaa.gov; haibin.su@tamuk.edu OI Su, Haibin/0000-0002-3645-2047; Zhan, Shengan/0000-0002-9303-1249; Wu, Qiusheng/0000-0001-5437-4073; Tong, Susanna /0000-0003-0308-5890 FU U.S. Army Corps of Engineers FX This study was funded by the U.S. Army Corps of Engineers. The U.S. Environmental Protection Agency and the Kentucky Department of Environmental Protection, Division of Water provided valuable in-kind services. Any use of trade, product, or firm names is for descriptive purposes only and does not imply endorsement by the U.S. Government. This article expresses only the personal views of the U.S. Army Corps of Engineers employees listed as authors and does not necessarily reflect the official positions of the Corps or of the Department of the Army. NR 78 TC 0 Z9 0 U1 13 U2 24 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0034-4257 EI 1879-0704 J9 REMOTE SENS ENVIRON JI Remote Sens. Environ. PD JUN 1 PY 2016 VL 178 BP 15 EP 30 DI 10.1016/j.rse.2016.03.002 PG 16 WC Environmental Sciences; Remote Sensing; Imaging Science & Photographic Technology SC Environmental Sciences & Ecology; Remote Sensing; Imaging Science & Photographic Technology GA DL3BC UT WOS:000375508200002 ER PT J AU Tier, D AF Tier, David TI What mix of brigade combat teams should the US Army Field? SO SMALL WARS AND INSURGENCIES LA English DT Article DE National defense; US Army; force structure; brigade combat teams (BCTs) AB During the past decade of war, the US Army has employed its forces in roles they were not intended to fulfill. The Army could have been better prepared if it had fielded a better mixture of forces. Instead of focusing on specific threats that narrowly specify which conflicts the Army will best be prepared for, the Army should maintain a broad range of capabilities that can meet a variety of circumstances. Accordingly, the Army should seek a force structure that exhibits a 3:1:1 ratio of Infantry, Armor, and Stryker brigade combat teams (BCTs) based on the possible range of conditions that US forces could face. C1 [Tier, David] US Army, Washington, DC USA. RP Tier, D (reprint author), US Army, Washington, DC USA. EM davidtier@yahoo.com NR 6 TC 0 Z9 0 U1 1 U2 1 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0959-2318 EI 1743-9558 J9 SMALL WAR INSUR JI Small War Insur. PD JUN PY 2016 VL 27 IS 3 SI SI BP 538 EP 549 DI 10.1080/09592318.2016.1151661 PG 12 WC International Relations SC International Relations GA DK4OU UT WOS:000374898800009 ER PT J AU Wesley, MJ Cheung, KF AF Wesley, Matthew J. Cheung, Kwok Fai TI Modeling of wave overtopping on vertical structures with the HLLS Riemann solver SO COASTAL ENGINEERING LA English DT Article DE Bottom discontinuities; Finite volume; Riemann solver; Shock-capturing; Vertical breakwater; Wave overtopping ID SHALLOW-WATER EQUATIONS; SOURCE TERMS; WAF METHOD; RUN-UP; TOPOGRAPHY; SIMULATION; INUNDATION; SCHEMES; FLOWS AB Depth-integrated wave models are commonly used in coastal engineering design and studies of near-shore processes, but the results might be unstable or questionable when overtopping of vertical structures is involved. The FILLS Riemann solver presented by Murillo and Garcia-Navarro (2012, Journal of Computational Physics) can account for shallow-water flow across a bottom step. We implement this solver in a second-order MUSCL-Hancock scheme and explore its use to describe overtopping of vertical structures through a nonlinear shallow-water model in one dimension. A series of numerical tests based on the Riemann problem assesses the characteristic approximation of the flow resulting from two-dimensional processes at the step. The model gives good agreement with simulations from OpenFOAM (an open-source computational fluid dynamics code) for rarefaction and surge and qualitative description for reflection at the step and shock waves generated by free fall of water. A laboratory experiment was conducted in a 9.14 m long flume to provide validation data for solitary wave overtopping of a vertical structure. Consistent with the numerical tests, the model produces slightly larger reflected waves from the structure and underestimates the amplitude and speed of the downstream waves generated by overtopping. Despite its simplicity, the HLLS solver performs reasonably well in approximating the overall processes and produces stable and efficient numerical results for practical application. (C) 2016 Elsevier B.V. All rights reserved. C1 [Wesley, Matthew J.; Cheung, Kwok Fai] Univ Hawaii Manoa, Dept Ocean & Resources Engn, Honolulu, HI 96822 USA. [Wesley, Matthew J.] US Army Corps Engineers, Coastal Engn Sect, 915 Wilshire Blvd,Ste 930, Los Angeles, CA 90017 USA. RP Cheung, KF (reprint author), Univ Hawaii Manoa, Dept Ocean & Resources Engn, Honolulu, HI 96822 USA. EM Matthew.Wesley@usace.army.mil; cheung@hawaii.edu FU Office of Naval Research [N00014-12-1-0721]; National Tsunami Hazard Mitigation Program through Hawaii Emergency Management Agency [NA14NWS4670042] FX The study was funded by the Office of Naval Research under Grant No. N00014-12-1-0721. Additional support was provided by the National Tsunami Hazard Mitigation Program under Grant No. NA14NWS4670042 through Hawaii Emergency Management Agency. We would like to thank the Department of Civil and Environmental Engineering, University of Hawaii for the use of the hydraulic laboratory and the two anonymous reviewers for their constructive criticisms. SOEST Contribution No. 9581. NR 32 TC 0 Z9 0 U1 6 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-3839 EI 1872-7379 J9 COAST ENG JI Coast. Eng. PD JUN PY 2016 VL 112 BP 28 EP 43 DI 10.1016/j.coastaleng.2016.02.002 PG 16 WC Engineering, Civil; Engineering, Ocean SC Engineering GA DL3AO UT WOS:000375506800004 ER PT J AU Mckay, SK Freeman, MC Covich, AP AF McKay, S. Kyle Freeman, Mary C. Covich, Alan P. TI Application of Effective Discharge Analysis to Environmental Flow Decision-Making SO ENVIRONMENTAL MANAGEMENT LA English DT Article DE Flow regime; Functional-equivalent discharge; Hierarchical linear models; Water management; Trait-based models ID FRESH-WATER; HYDROLOGIC ALTERATION; FISH ASSEMBLAGES; ECOLOGICAL CONSEQUENCES; RIVER SYSTEMS; STREAMS; REGIMES; VARIABILITY; ECOSYSTEMS; DYNAMICS AB Well-informed river management decisions rely on an explicit statement of objectives, repeatable analyses, and a transparent system for assessing trade-offs. These components may then be applied to compare alternative operational regimes for water resource infrastructure (e.g., diversions, locks, and dams). Intra- and inter-annual hydrologic variability further complicates these already complex environmental flow decisions. Effective discharge analysis (developed in studies of geomorphology) is a powerful tool for integrating temporal variability of flow magnitude and associated ecological consequences. Here, we adapt the effectiveness framework to include multiple elements of the natural flow regime (i.e., timing, duration, and rate-of-change) as well as two flow variables. We demonstrate this analytical approach using a case study of environmental flow management based on long-term (60 years) daily discharge records in the Middle Oconee River near Athens, GA, USA. Specifically, we apply an existing model for estimating young-of-year fish recruitment based on flow-dependent metrics to an effective discharge analysis that incorporates hydrologic variability and multiple focal taxa. We then compare three alternative methods of environmental flow provision. Percentage-based withdrawal schemes outcompete other environmental flow methods across all levels of water withdrawal and ecological outcomes. C1 [McKay, S. Kyle] US Army, Engn Res & Dev Ctr, Environm Lab, Athens, GA USA. [Freeman, Mary C.] US Geol Survey, Patuxent Wildlife Res Ctr, Athens, GA USA. [Covich, Alan P.] Univ Georgia, Odum Sch Ecol, Athens, GA 30602 USA. RP Mckay, SK (reprint author), US Army, Engn Res & Dev Ctr, Environm Lab, Athens, GA USA. EM kyle.mckay@usace.army.mil FU U.S. Army Corps of Engineers FX The U.S. Army Corps of Engineers funded this research through the Ecosystem Management and Restoration Research Program (http://www.el.erdc.usace.army.mil/emrrp/) and the long-term training program. The opinions reflected here are those of the authors and do not necessarily reflect those of the agency. Any use of trade, product, or firm names is for descriptive purposes only and does not imply endorsement by the U.S. Government. Rhett Jackson, John Schramski, and three anonymous referees reviewed a prior version of this document, and their constructive feedback is appreciated. NR 75 TC 0 Z9 0 U1 6 U2 23 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0364-152X EI 1432-1009 J9 ENVIRON MANAGE JI Environ. Manage. PD JUN PY 2016 VL 57 IS 6 BP 1153 EP 1165 DI 10.1007/s00267-016-0684-4 PG 13 WC Environmental Sciences SC Environmental Sciences & Ecology GA DK3QG UT WOS:000374831700002 PM 26961419 ER PT J AU Royzar, C Gillespie, TW Kawelo, K AF Royzar, Corey Gillespie, Thomas W. Kawelo, Kapua TI Landscape to site variations in species distribution models for endangered plants SO FOREST ECOLOGY AND MANAGEMENT LA English DT Article DE Species distribution model; Dry forest; Endangered species; Restoration; Hawaii; Oceanic island ID DRY FOREST RESTORATION; NEW-SOUTH-WALES; CLIMATE-CHANGE; FINE-SCALE; HABITAT SUITABILITY; SPATIAL SCALES; RARE PLANTS; LAND-COVER; PREDICTION; PATTERNS AB Present global plant extinction rates are 100-1000 times greater than pre-human levels and this is especially true on oceanic islands. There is a great need to model the distributions of endangered plants for reintroduction on oceanic islands, however, there are still questions concerning what is the most appropriate spatial scale and which environmental metrics should be included in order to guide restoration efforts. We examine the impact of spatial scale (1 km, 250 m, 10 m), environmental metrics (climate, topography, soils), and species overlap for 11 rare and endangered species in the dry forest of Oahu, Hawaii, which is one of the world's most endangered ecosystems, and contains some of the highest resolution data on species locations and environmental metrics for an oceanic island. At all spatial scales, the species distribution models reliably differentiated between occupied habitat and background for all 11 species (AUC >= 0.92). The relative importance of the environmental metrics did not vary across spatial scales with soil great group contributing most to the models followed by elevation, and mean precipitation of the driest quarter. The percent of the total island area with niche overlap for two or more species did not show any pattern with grain size, however, the 10 m model contained the largest areas of niche overlap for two or more species. There were 1292 10 m pixels on Oahu where models predict niche overlap for eight endangered species, however, only 1.2% of the total area is currently in protected areas. Results suggests that species distribution models are useful for predicting habitat suitability at all scales (1 km, 250 m,10 m), environmental metrics do not change across scales but high resolution data on soils, topography, and precipitation are needed, and 10 m resolution data are the best for informing restoration decisions for the endangered species on Hawaii and other oceanic islands. (C) 2016 Elsevier B.V. All rights reserved. C1 [Royzar, Corey; Gillespie, Thomas W.] Univ Calif Los Angeles, Dept Geog, Los Angeles, CA 90095 USA. [Kawelo, Kapua] US Army, Environm Div Directorate Publ Works, Garrison, HI USA. RP Royzar, C (reprint author), Univ Calif Los Angeles, Dept Geog, Los Angeles, CA 90095 USA. EM c.rovzar@ucla.edu; tg@geog.ucla.edu; kapua.kawelo@us.army.mil FU UCLA Department of Geography; Garden Club of America; National Geography Society FX This research was funded by the UCLA Department of Geography, Garden Club of America, and National Geography Society. We thank M. Keir for field assistance. We also thank T. Giambelluca for providing climate data and an anonymous reviewer for comments on an earlier draft. NR 102 TC 0 Z9 0 U1 16 U2 33 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-1127 EI 1872-7042 J9 FOREST ECOL MANAG JI For. Ecol. Manage. PD JUN 1 PY 2016 VL 369 BP 20 EP 28 DI 10.1016/j.foreco.2016.03.030 PG 9 WC Forestry SC Forestry GA DK8ID UT WOS:000375169500003 ER PT J AU Galloway, KM Greathouse, DG AF Galloway, Kathleen M. Greathouse, David G. TI Carpal Tunnel Syndrome in an Adolescent With Obesity SO PEDIATRIC PHYSICAL THERAPY LA English DT Article DE obesity; female; adolescent; carpal tunnel; human; median nerve; wrist ID BODY-MASS INDEX; RISK-FACTORS; POPULATION; CHILDHOOD; CHILDREN; COMPLICATIONS; ASSOCIATIONS; PREVALENCE; THERAPY; DISEASE AB Purpose: Carpal tunnel syndrome (CTS) is typically found in adults and may be associated with a variety of metabolic conditions including obesity. Obesity is a growing problem among today's youth, and adult diseases often associated with obesity are now being found in a younger population. This case study describes a young adolescent girl with obesity and CTS. Summary of Key Points: A history and examination were completed before electrophysiologic testing, and the patient had no evidence of any contributory pathology. Statement of Conclusions: There was electrophysiologic evidence of bilateral median nerve compromise at the wrist. The patient's diagnosis of CTS may be obesity related. Recommendations for Clinical Practice: Management of patients with obesity and CTS should also include education about weight management in addition to traditional interventions. This may be even more important for a child or adolescent with obesity and CTS. C1 [Galloway, Kathleen M.] Belmont Univ, Sch Phys Therapy, Nashville, TN USA. [Galloway, Kathleen M.] Blanchfield Army Community Hosp, Neurol Clin, Ft Campbell, KY USA. [Greathouse, David G.] Texas Phys Therapy Specialists, Clin Elect Serv, New Braunfels, TX USA. [Greathouse, David G.] US Army Baylor Univ, Doctoral Program Phys Therapy, Ft Sam Houston, TX USA. RP Galloway, KM (reprint author), 245 Cherokee Rd, Nashville, TN 37205 USA. EM Kathy.galloway@belmont.edu NR 36 TC 0 Z9 0 U1 3 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0898-5669 EI 1538-005X J9 PEDIATR PHYS THER JI Pediatr. Phys. Ther. PD SUM PY 2016 VL 28 IS 2 BP 248 EP 252 DI 10.1097/PEP.0000000000000236 PG 5 WC Pediatrics; Rehabilitation SC Pediatrics; Rehabilitation GA DI5JT UT WOS:000373535400027 PM 26963876 ER PT J AU Hu, X Compton, JR Leary, DH Olson, MA Lee, MS Cheung, J Ye, W Ferrer, M Southall, N Jadhav, A Morazzani, EM Glass, PJ Marugan, J Legler, PM AF Hu, Xin Compton, Jaimee R. Leary, Dagmar H. Olson, Mark A. Lee, Michael S. Cheung, Jonah Ye, Wenjuan Ferrer, Mark Southall, Noel Jadhav, Ajit Morazzani, Elaine M. Glass, Pamela J. Marugan, Juan Legler, Patricia M. TI Kinetic, Mutational, and Structural Studies of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine Protease SO BIOCHEMISTRY LA English DT Article ID PAPAIN-LIKE PROTEASE; CRYSTAL-STRUCTURE; SINDBIS-VIRUS; CATHEPSIN-B; NONCYTOPATHIC REPLICATION; RECOMBINANT PROTEINS; ESCHERICHIA-COLI; TRANSITION-STATE; MAMMALIAN-CELLS; NSP2 PROTEASE AB The Venezuelan equine encephalitis virus (VEEV) nonstructural protein 2 (nsP2) cysteine protease (EC 3.4.22.-) is essential for viral replication and is involved in the cytopathic effects (CPE) of the virus. The VEEV nsP2 protease is a member of MEROPS Clan CN and characteristically contains a papain-like protease linked to an S-adenosyl-L-methionine-dependent RNA methyltransferase (SAM MTase) domain. The protease contains an alternative active site motif, (475)NVCWAK(480), which differs from papain's (CGS(25)CWAFS), and the enzyme lacks a transition state-stabilizing residue homologous to GIn-19 in papain. To understand the roles of conserved residues in catalysis, we determined the structure of the free enzyme and the first structure of an inhibitor-bound alphaviral protease. The peptide-like E64d inhibitor was found to bind beneath a beta-hairpin at the interface of the SAM MTase and protease domains. His-546 adopted a conformation that differed from that found in the free enzyme; one or both of the conformers may assist in leaving group departure of either the amine or Cys thiolate during the catalytic cycle. Interestingly, E64c (200 mu M), the carboxylic acid form of the E64d ester, did not inhibit the nsP2 protease. To identify key residues involved in substrate binding, a number of mutants were analyzed. Mutation of the motif residue, N475A, led to a 24 fold reduction in k(cat)/K-m, and the conformation of this residue did not change after inhibition. N475 forms a hydrogen bond with R662 in the SAM MTase domain, and the R662A and R662K mutations both led to 16-fold decreases in k(cat)/K-m. N475 forms the base of the P1 binding site and likely orients the substrate for nucleophilic attack or plays a role in product release. An Asn homologous to N475 is similarly found in coronaviral papain-like proteases (PLpro) of the Severe Acute Respiratory Syndrome (SARS) virus and Middle East Respiratory Syndrome (MERS) virus. Mutation of another motif residue, K480A, led to a 9-fold decrease in k(cat) and k(cat)/K-m. K480 likely enhances the nucleophilicity of the Cys. Consistent with our substrate-bound models, the SAM MTase domain K706A mutation increased K-m 4.5-fold to 500 mu M. Within the beta-hairpin, the N545A mutation slightly but not significantly increased k(cat) and K-m. The structures and identified active site residues may facilitate the discovery of protease inhibitors with antiviral activity. C1 [Hu, Xin; Ye, Wenjuan; Ferrer, Mark; Southall, Noel; Jadhav, Ajit; Marugan, Juan] NIH, Chem Genom Ctr, Natl Ctr Adv Translat Sci, Rockville, MD 20850 USA. [Compton, Jaimee R.] Nova Res Inc, Alexandria, VA 22308 USA. [Cheung, Jonah] New York Struct Biol Ctr, New York, NY 10027 USA. [Olson, Mark A.; Lee, Michael S.; Morazzani, Elaine M.; Glass, Pamela J.] US Army, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Legler, Patricia M.] US Navy, Res Lab, Ctr Biomol Sci & Engn, Washington, DC 20375 USA. RP Legler, PM (reprint author), US Navy, Res Lab, Ctr Biomol Sci & Engn, Washington, DC 20375 USA. EM patricialegler@nrl.navy.mil FU DTRA [CB-SEED-SEED09-2-0061, CBCall4-CBM-05-2-0019] FX This work was supported by DTRA Projects CB-SEED-SEED09-2-0061 and CBCall4-CBM-05-2-0019. NR 75 TC 1 Z9 1 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0006-2960 J9 BIOCHEMISTRY-US JI Biochemistry PD MAY 31 PY 2016 VL 55 IS 21 BP 3007 EP 3019 DI 10.1021/acs.biochem.5b00992 PG 13 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA DN5ZT UT WOS:000377151100011 PM 27030368 ER PT J AU Vurgaftman, I Belenky, G Lin, Y Donetsky, D Shterengas, L Kipshidze, G Sarney, WL Svensson, SP AF Vurgaftman, I. Belenky, G. Lin, Y. Donetsky, D. Shterengas, L. Kipshidze, G. Sarney, W. L. Svensson, S. P. TI Interband absorption strength in long-wave infrared type-II superlattices with small and large superlattice periods compared to bulk materials SO APPLIED PHYSICS LETTERS LA English DT Article ID STRAINED-LAYER SUPERLATTICES; THIN-FILMS; PHOTODIODES; ALLOYS AB The absorption spectra for the antimonide-based type-II superlattices (SLs) for detection in the long-wave infrared (LWIR) are calculated and compared to the measured data for SLs and bulk materials with the same energy gap (HgCdTe and InAsSb). We include the results for the metamorphic InAsSbx/InAsSby SLs with small periods as well as the more conventional strain-balanced InAs/Ga(In)Sb and InAs/InAsSb SLs on GaSb substrates. The absorption strength in small-period metamorphic SLs is similar to the bulk materials, while the SLs with an average lattice constant matched to GaSb have significantly lower absorption. This is because the electron-hole overlap in the strain-balanced type-II LWIR SLs occurs primarily in the hole well, which constitutes a relatively small fraction of the total thickness. Published by AIP Publishing. C1 [Vurgaftman, I.] Naval Res Lab, Code 5613, Washington, DC 20375 USA. [Belenky, G.; Lin, Y.; Donetsky, D.; Shterengas, L.; Kipshidze, G.] SUNY Stony Brook, Stony Brook, NY 11794 USA. [Sarney, W. L.; Svensson, S. P.] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RP Belenky, G (reprint author), SUNY Stony Brook, Stony Brook, NY 11794 USA. EM gregory.belenky@stonybrook.edu OI LIN, YOUXI/0000-0002-9092-2302 FU U.S. Army Research Office [W911NF-16-2-0053]; U.S. National Science Foundation [DMR1160843] FX This work was supported by U.S. Army Research Office through Grant No. W911NF-16-2-0053 and by U.S. National Science Foundation through Grant No. DMR1160843. We acknowledge the valuable suggestions of Dr. Jerry Meyer, Dr. Serge Luryi, and Dr. Sergey Suchalkin. NR 21 TC 2 Z9 2 U1 16 U2 26 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAY 30 PY 2016 VL 108 IS 22 AR 222101 DI 10.1063/1.4953035 PG 5 WC Physics, Applied SC Physics GA DP3XE UT WOS:000378428400020 ER PT J AU Lai, CW Schwab, M Hill, SC Santarpia, J Pan, YL AF Lai, Chih Wei Schwab, Mark Hill, Steven C. Santarpia, Joshua Pan, Yong-Le TI Raman scattering and red fluorescence in the photochemical transformation of dry tryptophan particles SO OPTICS EXPRESS LA English DT Article ID AROMATIC-AMINO-ACIDS; EXCITED-STATE CHEMISTRY; AIRBORNE BIOLOGICAL PARTICLES; PROTEIN SECONDARY STRUCTURE; EXCITATION PROFILES; SIDE-CHAINS; TYROSINE; SPECTROSCOPY; PEPTIDES; SPECTRA AB Tryptophan is a fluorescent amino acid common in proteins. Its absorption is largest for wavelengths lambda less than or similar to 290 nm and its fluorescence emissions peak around 300-350 nm, depending upon the local environment. Here we report the observation of red fluorescence near 600 nm emerging from 488-nm continuous-wave (CW) laser photoexcitation of dry tryptophan (Trp) particles. With an excitation intensity below 0.5 kW/cm(2), dry Trp particles yield distinctive Raman scattering peaks in the presence of relatively weak and spectrally broad emissions with lambda similar to 500-700 nm, allowing estimation of particle temperature at low excitation intensities. When the photoexcitation intensity is increased to 1 kW/cm(2) or more for a few minutes, fluorescence intensity dramatically increases by more than two orders of magnitude. The fluorescence continues to increase in intensity and gradually shift to the red when photoexcitation intensity and the duration of exposure are increased. The resulting products absorb at visible wavelengths and generate red fluorescence with lambda similar to 650-800 nm with 633-nm CW laser excitation. We attribute the emergence of orange and red fluorescence in the Trp products to a photochemical transformation that is instigated by weak optical transitions to triplet states in Trp with 488-nm excitation and which may be expedited by a photothermal effect. (C) 2016 Optical Society of America C1 [Lai, Chih Wei; Schwab, Mark; Hill, Steven C.; Pan, Yong-Le] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Lai, Chih Wei] Michigan State Univ, Dept Phys & Astron, E Lansing, MI 48824 USA. [Santarpia, Joshua] Sandia Natl Labs, Albuquerque, NM 87123 USA. RP Lai, CW (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.; Lai, CW (reprint author), Michigan State Univ, Dept Phys & Astron, E Lansing, MI 48824 USA. EM cwlai@msu.edu RI Lai, Chih Wei/E-4945-2010 OI Lai, Chih Wei/0000-0003-3571-4671 FU Defense Threat Reduction Agency (DTRA) [HDTRS1518237, HDTRA1619734]; U.S. Army Research Laboratory (ARL) mission funds; National Science Foundation (NSF) under NSF grant [DMR-0955944]; Army Research Laboratory [W911NF-12-2-0019] FX We thank Shouwen Hu for technical support. This work was supported by the Defense Threat Reduction Agency (DTRA) under HDTRS1518237 and HDTRA1619734 as well as the U.S. Army Research Laboratory (ARL) mission funds. Research conducted by C.W.L. was partly sponsored by the National Science Foundation (NSF) under the NSF grant DMR-0955944. Research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-12-2-0019. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 46 TC 0 Z9 0 U1 6 U2 12 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD MAY 30 PY 2016 VL 24 IS 11 BP 1654 EP 1667 DI 10.1364/OE.24.011654 PG 14 WC Optics SC Optics GA DO0KM UT WOS:000377467800033 PM 27410091 ER PT J AU Ivashchenko, VI Turchi, PEA Veprek, S Shevchenko, VI Leszczynski, J Gorb, L Hill, F AF Ivashchenko, V. I. Turchi, P. E. A. Veprek, S. Shevchenko, V. I. Leszczynski, Jerzy Gorb, Leonid Hill, Frances TI First-principles study of crystalline and amorphous AlMgB14-based materials SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID 1ST PRINCIPLES; THIN-FILMS; BORON; BORIDES; DIFFRACTION AB We report first-principles investigations of crystalline and amorphous boron and M1(x)M2(y)X(z)B(14-z) (M1, M2 = Al, Mg, Li, Na, Y; X = Ti, C, Si) phases (so-called "BAM" materials). Phase stability is analyzed in terms of formation energy and dynamical stability. The atomic configurations as well as the electronic and phonon density states of these phases are compared. Amorphous boron consists of distorted icosahedra, icosahedron fragments, and dioctahedra, connected by an amorphous network. The presence of metal atoms in amorphous BAM materials precludes the formation of icosahedra. For all the amorphous structures considered here, the Fermi level is located in the mobility gap independent of the number of valence electrons. The intra-icosahedral vibrations are localized in the range of 800 cm(-1), whereas the inter-icosahedral vibrations appear at higher wavenumbers. The amorphization leads to an enhancement of the vibrations in the range of 1100-1250 cm(-1). The mechanical properties of BAM materials are investigated at equilibrium and under shear and tensile strain. The anisotropy of the ideal shear and tensile strengths is explained in terms of a layered structure of the B-12 units. The strength of amorphous BAM materials is lower than that of the crystalline counterparts because of the partial fragmentation of the boron icosahedra in amorphous structures. The strength enhancement found experimentally for amorphous boron-based films is very likely related to an increase in film density, and the presence of oxygen impurities. For crystalline BAM materials, the icosahedra are preserved during elongation upon tension as well as upon shear in the (010)[100] slip system. Published by AIP Publishing. C1 [Ivashchenko, V. I.; Shevchenko, V. I.] Natl Acad Sci Ukraine, Inst Problems Mat Sci, Krzhyzhanosky Str 3, UA-03142 Kiev, Ukraine. [Turchi, P. E. A.] Lawrence Livermore Natl Lab, L-352,POB 808, Livermore, CA 94551 USA. [Veprek, S.] Tech Univ Munich, Dept Chem, Lichtenbergstr 4, D-85747 Garching, Germany. [Leszczynski, Jerzy; Gorb, Leonid] Jackson State Univ, Dept Chem & Biochem, Interdisciplinary Ctr Nanotox, Jackson, MS 39217 USA. [Gorb, Leonid] Badger Tech Serv LLC, Vicksburg, MS 39180 USA. [Hill, Frances] US Army, Erdc, Vicksburg, MS 39180 USA. RP Shevchenko, VI (reprint author), Natl Acad Sci Ukraine, Inst Problems Mat Sci, Krzhyzhanosky Str 3, UA-03142 Kiev, Ukraine. EM shev@materials.kiev.ua RI Veprek, Stan/C-1248-2008 OI Veprek, Stan/0000-0002-6016-3093 FU STCU [5964]; U.S. Department of Energy by the Lawrence Livermore National Laboratory [DE-AC52-07NA27344]; Company SHM s.r.o. (Czech Republic) FX This work was supported by the STCU Contract No. 5964. The work of P.T. was performed under the auspices of the U.S. Department of Energy by the Lawrence Livermore National Laboratory under Contract No. DE-AC52-07NA27344. The authors are grateful to the directorate of the Summer Institute at Jackson State University for the opportunity to perform large-scale calculations. S.V. thanks the Company SHM s.r.o. (Czech Republic) for financial support. We also thank Dr. M.G.J. Veprek-Heijman for critical reading of the manuscript and many useful comments. NR 48 TC 1 Z9 1 U1 4 U2 15 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD MAY 28 PY 2016 VL 119 IS 20 AR 205105 DI 10.1063/1.4952391 PG 13 WC Physics, Applied SC Physics GA DO3YM UT WOS:000377718700037 ER PT J AU Chaudhury, S Ockenhouse, CF Regules, JA Dutta, S Wallqvist, A Jongert, E Waters, NC Lemiale, F Bergmann-Leitner, E AF Chaudhury, Sidhartha Ockenhouse, Christian F. Regules, Jason A. Dutta, Sheetij Wallqvist, Anders Jongert, Erik Waters, Norman C. Lemiale, Franck Bergmann-Leitner, Elke TI The biological function of antibodies induced by the RTS,S/AS01 malaria vaccine candidate is determined by their fine specificity SO MALARIA JOURNAL LA English DT Article DE Malaria; Antibody; Phagocytosis; Epitope; Protection ID FALCIPARUM CIRCUMSPOROZOITE PROTEIN; C-TERMINAL FRAGMENT; PLASMODIUM-BERGHEI; IMMUNE-RESPONSE; LEISHMANIA PARASITES; PROTECTIVE RESPONSE; NAIVE ADULTS; DOUBLE-BLIND; EFFICACY; CELL AB Background: Recent vaccine studies have shown that the magnitude of an antibody response is often insufficient to explain efficacy, suggesting that characteristics regarding the quality of the antibody response, such as its fine specificity and functional activity, may play a major role in protection. Previous studies of the lead malaria vaccine candidate, RTS,S, have shown that circumsporozoite protein (CSP)-specific antibodies and CD4(+) T cell responses are associated with protection, however the role of fine specificity and biological function of CSP-specific antibodies remains to be elucidated. Here, the relationship between fine specificity, opsonization-dependent phagocytic activity and protection in RTS, S-induced antibodies is explored. Methods: A new method for measuring the phagocytic activity mediated by CSP-specific antibodies in THP-1 cells is presented and applied to samples from a recently completed phase 2 RTS,S/AS01 clinical trial. The fine specificity of the antibody response was assessed using ELISA against three antigen constructs of CSP: the central repeat region, the C-terminal domain and the full-length protein. A multi-parameter analysis of phagocytic activity and fine-specificity data was carried out to identify potential correlates of protection in RTS, S. Results: Results from the newly developed assay revealed that serum samples from RTS, S recipients displayed a wide range of robust and repeatable phagocytic activity. Phagocytic activity was correlated with full-length CSP and C-terminal specific antibody titres, but not to repeat region antibody titres, suggesting that phagocytic activity is primarily driven by C-terminal antibodies. Although no significant difference in overall phagocytic activity was observed with respect to protection, phagocytic activity expressed as 'opsonization index', a relative measure that normalizes phagocytic activity with CS antibody titres, was found to be significantly lower in protected subjects than non-protected subjects. Conclusions: Opsonization index was identified as a surrogate marker of protection induced by the RTS,S/AS01 vaccine and determined how antibody fine specificity is linked to opsonization activity. These findings suggest that the role of opsonization in protection in the RTS, S vaccine may be more complex than previously thought, and demonstrate how integrating multiple immune measures can provide insight into underlying mechanisms of immunity and protection. C1 [Chaudhury, Sidhartha; Wallqvist, Anders] US Army Med Res & Mat Command, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA. [Ockenhouse, Christian F.; Lemiale, Franck] PATH Malaria Vaccine Initiat, Washington, DC USA. [Regules, Jason A.] US Army, Dept Clin Res, Med Res Inst Infect Dis, Ft Detrick, MD USA. [Dutta, Sheetij; Waters, Norman C.; Bergmann-Leitner, Elke] Walter Reed Army Inst Res, Malaria Vaccine Branch, US Mil Malaria Res Program, 503 Robert Grant Ave,3W53, Silver Spring, MD 20910 USA. [Jongert, Erik] GSK Vaccine, Rixensart, Belgium. RP Bergmann-Leitner, E (reprint author), Walter Reed Army Inst Res, Malaria Vaccine Branch, US Mil Malaria Res Program, 503 Robert Grant Ave,3W53, Silver Spring, MD 20910 USA. EM elke.s.bergmannleitner.civ@mail.mil FU PATH Malaria Vaccine Initiative FX We would like to thank Ms. Tanisha Robinson and Ms. Lisa Dlugosz for technical assistance and Dominique Wauters (GSK Vaccines) for his input into the scope of work. The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the US Army or the US Department of Defense. This paper has been approved for public release with unlimited distribution. Funding for this study was provided by PATH Malaria Vaccine Initiative. NR 35 TC 0 Z9 0 U1 7 U2 10 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD MAY 28 PY 2016 VL 15 AR 301 DI 10.1186/s12936-016-1348-9 PG 12 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA DN6JN UT WOS:000377180200004 PM 27245446 ER PT J AU Dodds, SG Livi, CB Parihar, M Hsu, HK Benavides, AD Morris, J Javors, M Strong, R Christy, B Hasty, P Sharp, ZD AF Dodds, Sherry G. Livi, Carolina B. Parihar, Manish Hsu, Hang-Kai Benavides, Adriana D. Morris, Jay Javors, Martin Strong, Randy Christy, Barbara Hasty, Paul Sharp, Zelton Dave TI Adaptations to chronic rapamycin in mice SO PATHOBIOLOGY OF AGING AND AGE-RELATED DISEASES LA English DT Article DE mTORC1; rapamycin; translation; ribosome biogenesis ID EXTENDS LIFE-SPAN; GENETICALLY HETEROGENEOUS MICE; INITIATION-FACTOR 4E; EIF4E/4E-BP RATIO; MAMMALIAN TARGET; MTOR; INHIBITION; CANCER; EIF4E; PHOSPHORYLATION AB Rapamycin inhibits mechanistic (or mammalian) target of rapamycin (mTOR) that promotes protein production in cells by facilitating ribosome biogenesis (RiBi) and eIF4E-mediated 5'cap mRNA translation. Chronic treatment with encapsulated rapamycin (eRapa) extended health and life span for wild-type and cancer-prone mice. Yet, the long-term consequences of chronic eRapa treatment are not known at the organ level. Here, we report our observations of chronic eRapa treatment on mTORC1 signaling and RiBi in mouse colon and visceral adipose. As expected, chronic eRapa treatment decreased detection of phosphorylated mTORC1/S6K substrate, ribosomal protein (rpS6) in colon and fat. However, in colon, contrary to expectations, there was an upregulation of 18S rRNA and some ribosomal protein genes (RPGs) suggesting increased RiBi. Among RPGs, eRapa increases rpl22l1 mRNA but not its paralog rpl22. Furthermore, there was an increase in the cap-binding protein, eIF4E relative to its repressor 4E-BP1 suggesting increased translation. By comparison, in fat, there was a decrease in the level of 18S rRNA (opposite to colon), while overall mRNAs encoding ribosomal protein genes appeared to increase, including rpl22, but not rpl22l1 (opposite to colon). In fat, there was a decrease in eIF4E relative to actin (opposite to colon) but also an increase in the eIF4E/4E-BP1 ratio likely due to reductions in 4E-BP1 at our lower eRapa dose (similar to colon). Thus, in contrast to predictions of decreased protein production seen in cell-based studies, we provide evidence that colon from chronically treated mice exhibited an adaptive 'pseudo-anabolic' state, which is only partially present in fat, which might relate to differing tissue levels of rapamycin, cell-type-specific responses, and/or strain differences. C1 [Dodds, Sherry G.; Livi, Carolina B.; Parihar, Manish; Hsu, Hang-Kai; Morris, Jay; Christy, Barbara; Hasty, Paul; Sharp, Zelton Dave] Univ Texas Hlth Sci Ctr San Antonio, Inst Biotechnol, Dept Mol Med, San Antonio, TX 78229 USA. [Livi, Carolina B.] Agilent Technol, Santa Clara, CA USA. [Hsu, Hang-Kai] City Hope Natl Med Ctr, KCRB 2018, 1500 E Duarte Rd, Duarte, CA 91010 USA. [Benavides, Adriana D.] Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol & Immunol, San Antonio, TX 78229 USA. [Benavides, Adriana D.] Childrens Hosp Philadelphia, Infect Dis Res Div, Philadelphia, PA 19104 USA. [Javors, Martin] Univ Texas Hlth Sci Ctr San Antonio, Dept Psychiat, San Antonio, TX 78229 USA. [Javors, Martin; Strong, Randy] Univ Texas Hlth Sci Ctr San Antonio, Dept Pharmacol, San Antonio, TX 78229 USA. [Strong, Randy; Hasty, Paul; Sharp, Zelton Dave] Univ Texas Hlth Sci Ctr San Antonio, Barshop Inst Longev & Aging Studies, San Antonio, TX 78229 USA. [Strong, Randy] South Texas Vet Hlth Care Syst, Geriatr Res Educ & Clin Ctr, San Antonio, TX USA. [Christy, Barbara] US Army Inst Surg Res, Coagulat & Blood Res Grp, JBSA Ft Sam Houston, TX USA. [Hasty, Paul; Sharp, Zelton Dave] Canc Therapy & Res Ctr S Texas, 4450 Med Dr, San Antonio, TX 78229 USA. RP Hasty, P; Sharp, ZD (reprint author), Dept Mol Med, 15355 Lambda Dr, San Antonio, TX 78245 USA. EM hastye@uthscsa.edu; sharp@uthscsa.edu FU NCI NIH HHS [R01 CA193835]; NIA NIH HHS [P30 AG013319, U01 AG022307] NR 59 TC 2 Z9 2 U1 1 U2 1 PU CO-ACTION PUBLISHING PI JARFALLA PA RIPVAGEN 7, JARFALLA, SE-175 64, SWEDEN EI 2001-0001 J9 PATHOBIOL AGING AGE JI Pathobiol. Aging Age-relat. Dis. PD MAY 27 PY 2016 VL 6 AR 31688 DI 10.3402/pba.v6.31688 PG 11 WC Pathology SC Pathology GA DT4ET UT WOS:000381433600001 PM 27237224 ER PT J AU Su, J Felton, M Lei, LQ McCormick, MP Delgado, R Pe, AS AF Su, Jia Felton, Melvin Lei, Liqiao McCormick, M. Patrick Delgado, Ruben Pe, Alexandra St. TI Lidar remote sensing of cloud formation caused by low-level jets SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES LA English DT Article ID SOUTHERN GREAT-PLAINS; BOUNDARY-LAYER; JOHNSTOWN FLOOD; CLIMATOLOGY; SITE AB In May 2014, the East Hampton Roads Aerosol Flux campaign was conducted at Hampton University to examine small-scale aerosol transport using aerosol, Raman, and Doppler lidars and rawindsonde launches. We present the results of analyses performed on these high-resolution planetary boundary layer and lower atmospheric measurements, with a focus on the low-level jets (LLJs) that form in this region during spring and summer. We present a detailed case study of a LLJ lasting from evening of 20 May to morning of 21 May using vertical profiles of aerosol backscatter, wind speed and direction, water vapor mixing ratio, temperature, and turbulence structure. We show with higher resolution than in previous studies that enhanced nighttime turbulence triggered by LLJs can cause the aerosol and water vapor content of the boundary layer to be transported vertically and form a well-mixed region containing the cloud condensation nuclei that are necessary for cloud formation. C1 [Su, Jia; Lei, Liqiao; McCormick, M. Patrick] Hampton Univ, Dept Atmospher & Planetary Sci, Ctr Atmospher Sci, Hampton, VA 23668 USA. [Felton, Melvin] US Army Res Lab, Adelphi, MD 20783 USA. [Delgado, Ruben; Pe, Alexandra St.] Univ Maryland Baltimore Cty, Joint Ctr Earth Syst Technol, Baltimore, MD 21228 USA. RP Felton, M (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM melvin.a.felton.civ@mail.mil RI Delgado, Ruben/F-9753-2016 OI Delgado, Ruben/0000-0002-7133-2462 FU Partnership in Research and Transition cooperative agreement - U.S. Army Research Office [551150-211150] FX This research was supported by the Partnership in Research and Transition cooperative agreement funded by the U.S. Army Research Office, award 551150-211150. The paper data are from this link (http://sol.hamptonu.edu/hu-lidar/hu-lidar-data-products/). NR 28 TC 0 Z9 0 U1 4 U2 4 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-897X EI 2169-8996 J9 J GEOPHYS RES-ATMOS JI J. Geophys. Res.-Atmos. PD MAY 27 PY 2016 VL 121 IS 10 BP 5904 EP 5911 DI 10.1002/2015JD024590 PG 8 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA DT6YB UT WOS:000381629900047 ER PT J AU Gupta, P Sharma, A Spurgers, KB Bakken, RR Eccleston, LT Cohen, JW Honnold, SP Glass, PJ Maheshwari, RK AF Gupta, Paridhi Sharma, Anuj Spurgers, Kevin B. Bakken, Russell R. Eccleston, Lori T. Cohen, Jeffrey W. Honnold, Shelley P. Glass, Pamela J. Maheshwari, Radha K. TI 1,5-Iodonaphthyl azide-inactivated V3526 protects against aerosol challenge with virulent venezuelan equine encephalitis virus SO VACCINE LA English DT Article DE Venezuelan equine encephalitis; Vaccine; Inactivated; Iodonaphthyl azide; Aerosol challenge; Protection ID STRUCTURAL INTEGRITY; NONHUMAN-PRIMATES; PRESERVATION; VACCINES; INFECTION; RESPONSES; ANTIBODY; VEEV AB Venezuelan equine encephalitis virus (VEEV) is a New World alphavirus. VEEV is highly infectious in aerosolized form and has been identified as a bio-terrorism agent. There is no licensed vaccine for prophylaxis against VEEV. The current IND vaccine is poorly immunogenic and does not protect against an aerosol challenge with virulent VEEV. We have previously shown that VEEV inactivated by 1,5-iodonaphthyl azide (INA) protects against footpad challenge with virulent VEEV. In this study, we inactivated an attenuated strain of VEEV, V3526, with INA and evaluated its protective efficacy against aerosol challenge with wild type VEEV. We demonstrated that among three routes of immunization, intramuscular immunization with INA-inactivate V3526 (INA-iV3526) provided complete protection against aerosol challenge with virulent VEEV. Our data suggests that INA-iV3526 can be explored further for development as an effective vaccine candidate against aerosol challenge of virulent VEEV. (C) 2016 Published by Elsevier Ltd. C1 [Gupta, Paridhi; Sharma, Anuj; Maheshwari, Radha K.] Uniformed Serv Univ Hlth Sci, Dept Pathol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. [Spurgers, Kevin B.; Bakken, Russell R.; Eccleston, Lori T.; Cohen, Jeffrey W.; Honnold, Shelley P.; Glass, Pamela J.] US Army, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. RP Sharma, A (reprint author), 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM anuj.sharma.ctr@usuhs.edu FU Defense Threat Reduction Agency FX This work was supported by a grant from Defense Threat Reduction Agency. The opinions expressed herein are of those of the author(s) and are not necessarily representative of those of the Uniformed Services University of the Health Sciences (USUHS), USAMRIID, the Department of Defense (DoD); or, the United States Army, Navy, or Air Force. NR 20 TC 0 Z9 0 U1 1 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD MAY 27 PY 2016 VL 34 IS 25 BP 2762 EP 2765 DI 10.1016/j.vaccine.2016.04.049 PG 4 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA DN8GQ UT WOS:000377317600002 PM 27129427 ER PT J AU Ben Salem, H Damarla, T Sudusinghe, K Stechele, W Bhattacharyya, SS AF Ben Salem, Haifa Damarla, Thyagaraju Sudusinghe, Kishan Stechele, Walter Bhattacharyya, Shuvra S. TI Adaptive tracking of people and vehicles using mobile platforms SO EURASIP JOURNAL ON ADVANCES IN SIGNAL PROCESSING LA English DT Article DE Acoustic sensors; Dataflow graphs; DDDAS; Mobile platforms; Signal processing systems; Target tracking ID CLASSIFICATION AB Tracking algorithms have important applications in detection of humans and vehicles for border security and other areas. For large-scale deployment of such algorithms, it is critical to provide methods for their cost- and energy-efficient realization. To this end, commodity mobile devices have significant potential for use as prototyping and testing platforms due to their low cost, widespread availability, and integration of advanced communications, sensing, and processing features. Prototypes developed on mobile platforms can be tested, fine-tuned, and demonstrated in the field and then provide reference implementations for application-specific disposable sensor node implementations that are targeted for deployment. In this paper, we develop a novel, adaptive tracking system that is optimized for energy-efficient, real-time operation on off-the-shelf mobile platforms. Our tracking system applies principles of dynamic data-driven application systems (DDDAS) to periodically monitor system operating characteristics and apply these measurements to dynamically adapt the specific classifier configurations that the system employs. Our resulting adaptive approach enables powerful optimization of trade-offs among energy consumption, real-time performance, and tracking accuracy based on time-varying changes in operational characteristics. Through experiments employing an Android-based tablet platform, we demonstrate the efficiency of our proposed tracking system design for multimode detection of human and vehicle targets. C1 [Ben Salem, Haifa; Sudusinghe, Kishan; Bhattacharyya, Shuvra S.] Univ Maryland, College Pk, MD 20742 USA. [Damarla, Thyagaraju] US Army Res Lab, Army Res Lab, Adelphi, MD USA. [Stechele, Walter] Tech Univ Munich, Inst Integrated Syst, D-80290 Munich, Germany. [Bhattacharyya, Shuvra S.] Tampere Univ Technol, FIN-33101 Tampere, Finland. RP Ben Salem, H (reprint author), Univ Maryland, College Pk, MD 20742 USA. EM haifa.ben-salem@tum.de NR 25 TC 0 Z9 0 U1 5 U2 9 PU SPRINGER INTERNATIONAL PUBLISHING AG PI CHAM PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND SN 1687-6180 J9 EURASIP J ADV SIG PR JI EURASIP J. Adv. Signal Process. PD MAY 26 PY 2016 AR 65 DI 10.1186/s13634-016-0356-9 PG 12 WC Engineering, Electrical & Electronic SC Engineering GA DN3YG UT WOS:000376999600001 ER PT J AU Neupane, MR Garrett, GA Rudin, S Andzelm, JW AF Neupane, M. R. Garrett, G. A. Rudin, S. Andzelm, J. W. TI Phase dependent structural and electronic properties of lanthanum orthophosphate (LaPO4) SO JOURNAL OF PHYSICS-CONDENSED MATTER LA English DT Article DE lanthanum; rare-earth; hybrid functionals; PBE; energy gap ID BRILLOUIN-ZONE INTEGRATIONS; RARE-EARTH ORTHOPHOSPHATES; INITIO MOLECULAR-DYNAMICS; TOTAL-ENERGY CALCULATIONS; WAVE BASIS-SET; OPTICAL-PROPERTIES; EFFECTIVE-MASS; DOPED LAPO4; NANOCRYSTALS; NANORODS AB We study the phase-dependent structural and electronic properties of bulk LaPO4, using density functional theory (DFT). The applicability of conventional semi-local and hybrid functionals in predicting structural and electronic properties of monoclinic and hexagonal LaPO4 is evaluated by comparing results to available experimental data. The monoclinic LaPO4 was found to be more stable than the hexagonal phase in ambient conditions with a small energy difference, suggesting a possibility of a phase transition. Both the phases in the bulk form are found to be diamagnetic with indirect energy gaps. These results are consistent with available experimental results. In the monoclinic phase, the hybrid functionals predict indirect band gap at about 8 eV. Furthermore, the calculated indirect-direct transition energy offset (Delta E) in the hexagonal phase was three times lower than the monoclinic phase. Our calculations based on hybrid functionals also reveal that the states near the conduction band edge in the hexagonal LaPO4 are strongly hybridized between La and PO4 states. By analyzing the band dispersion around the band edges, we show that the hexagonal phase has lighter electron effective mass, as compared to the monoclinic phase. With a larger energy gap, smaller Delta E, and smaller electron effective mass, the hexagonal LaPO4 might be a promising candidate material as an n-type transparent oxide. C1 [Neupane, M. R.; Andzelm, J. W.] US Army Res Lab, RDRL WMM G, 4600 Aberdeen Proving Ground, Aberdeen, MD 21005 USA. [Garrett, G. A.; Rudin, S.] US Army Res Lab, RDRL SEE M, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RP Neupane, MR; Andzelm, JW (reprint author), US Army Res Lab, RDRL WMM G, 4600 Aberdeen Proving Ground, Aberdeen, MD 21005 USA. EM mahesh.neupane.ctr@mail.mil; jan.w.andzelm.civ@mail.mil FU DOD High Performance Computing Modernization Program at the U.S. Air Force Research Laboratory; U.S. Army Engineer Research and Development Center DoD Supercomputing Resource Centers FX We acknowledge helpful discussions with Dr Tanya L Chantawansri and Dr Krista Limmer. MRN was supported by an appointment to the Postgraduate Research Participation Program at the U.S. Army Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USARL. This work was supported by grants of computer time from the DOD High Performance Computing Modernization Program at the U.S. Air Force Research Laboratory and U.S. Army Engineer Research and Development Center DoD Supercomputing Resource Centers. NR 60 TC 1 Z9 1 U1 6 U2 8 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0953-8984 EI 1361-648X J9 J PHYS-CONDENS MAT JI J. Phys.-Condes. Matter PD MAY 25 PY 2016 VL 28 IS 20 AR 205501 DI 10.1088/0953-8984/28/20/205501 PG 10 WC Physics, Condensed Matter SC Physics GA DM5RZ UT WOS:000376409000005 PM 27114454 ER PT J AU Rao, P Hromadka, TV AF Rao, Prasada Hromadka, Theodore V., II TI Numerical modeling of rapidly varying flows using HEC-RAS and WSPG models SO SPRINGERPLUS LA English DT Article DE Open channel; Roughness; Hydraulic jump; Froude number ID HYDRAULIC JUMP; SIMULATION; EQUATIONS; SCHEMES AB The performance of two popular hydraulic models (HEC-RAS and WSPG) for modeling hydraulic jump in an open channel is investigated. The numerical solutions are compared with a new experimental data set obtained for varying channel bottom slopes and flow rates. Both the models satisfactorily predict the flow depths and location of the jump. The end results indicate that the numerical models output is sensitive to the value of chosen roughness coefficient. For this application, WSPG model is easier to implement with few input variables. C1 [Rao, Prasada] Calif State Univ Fullerton, Dept Civil & Environm Engn, Fullerton, CA 92831 USA. [Hromadka, Theodore V., II] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. RP Rao, P (reprint author), Calif State Univ Fullerton, Dept Civil & Environm Engn, Fullerton, CA 92831 USA. EM prasad@fullerton.edu NR 13 TC 0 Z9 0 U1 2 U2 4 PU SPRINGER INTERNATIONAL PUBLISHING AG PI CHAM PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND SN 2193-1801 J9 SPRINGERPLUS JI SpringerPlus PD MAY 20 PY 2016 VL 5 AR 662 DI 10.1186/s40064-016-2199-0 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DO2JM UT WOS:000377606000001 PM 27350903 ER PT J AU Clifford, R Sparks, M Hosford, E Ong, A Richesson, D Fraser, S Kwak, Y Miller, S Julius, M McGann, P Lesho, E AF Clifford, Robert Sparks, Michael Hosford, Eve Ong, Ana Richesson, Douglas Fraser, Susan Kwak, Yoon Miller, Sonia Julius, Michael McGann, Patrick Lesho, Emil TI Correlating Cleaning Thoroughness with Effectiveness and Briefly Intervening to Affect Cleaning Outcomes: How Clean Is Cleaned? SO PLOS ONE LA English DT Article ID RESISTANT STAPHYLOCOCCUS-AUREUS; DISINFECTION TISSUE DISPENSERS; COMPARING SURFACE DISINFECTION; CARE-ASSOCIATED INFECTIONS; EVIDENCE-BASED DESIGN; HOSPITAL ROOM; CLINICAL-PRACTICE; OVERWEIGHT; PARADIGM; PITFALLS AB Objectives The most efficient approach to monitoring and improving cleaning outcomes remains unresolved. We sought to extend the findings of a previous study by determining whether cleaning thoroughness (dye removal) correlates with cleaning efficacy (absence of molecular or cultivable biomaterial) and whether one brief educational intervention improves cleaning outcomes. Design Before-after trial. Setting Newly built community hospital. Intervention 90 minute training refresher with surface-specific performance results. Methods Dye removal, measured by fluorescence, and biomaterial removal and acquisition, measured with culture and culture-independent PCR-based assays, were clandestinely assessed for eight consecutive months. At this midpoint, results were presented to the cleaning staff (intervention) and assessments continued for another eight consecutive months. Results 1273 surfaces were sampled before and after terminal room cleaning. In the short-term, dye removal increased from 40.3% to 50.0% (not significant). For the entire study period, dye removal also improved but not significantly. After the intervention, the number of rooms testing positive for specific pathogenic species by culturing decreased from 55.6% to 36.6% (not significant), and those testing positive by PCR fell from 80.6% to 53.7%(P = 0.016). For nonspecific biomaterial on surfaces: a) removal of cultivable Gram-negatives (GN) trended toward improvement (P = 0.056); b) removal of any cultivable growth was unchanged but acquisition (detection of biomaterial on post-cleaned surfaces that were contaminant-free before cleaning) worsened (P = 0.017); c) removal of PCR-based detection of bacterial DNA improved (P = 0.046), but acquisition worsened (P = 0.003); d) cleaning thoroughness and efficacy were not correlated. Conclusion At this facility, a minor intervention or minimally more aggressive cleaning may reduce pathogen-specific contamination, but not without unintended consequences. C1 [Clifford, Robert; Sparks, Michael; Hosford, Eve; Ong, Ana; Richesson, Douglas; Kwak, Yoon; Julius, Michael; McGann, Patrick; Lesho, Emil] Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD USA. [Fraser, Susan; Miller, Sonia] Ft Belvoir Community Hosp, Dept Infect Dis & Infect Control, Ft Belvoir, VA USA. RP Lesho, E (reprint author), Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD USA. EM carolinelesho@yahoo.com FU U.S. Army Medical Command; Department of Defense Global Emerging Infection Surveillance and Response System FX This work was funded by the U.S. Army Medical Command and the Department of Defense Global Emerging Infection Surveillance and Response System. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 27 TC 0 Z9 0 U1 2 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAY 19 PY 2016 VL 11 IS 5 AR e0155779 DI 10.1371/journal.pone.0155779 PG 12 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DM4BR UT WOS:000376291100100 PM 27196635 ER PT J AU Lesho, E Clifford, R Onmus-Leone, F Appalla, L Snesrud, E Kwak, Y Ong, A Maybank, R Waterman, P Rohrbeck, P Julius, M Roth, A Martinez, J Nielsen, L Steele, E McGann, P Hinkle, M AF Lesho, Emil Clifford, Robert Onmus-Leone, Fatma Appalla, Lakshmi Snesrud, Erik Kwak, Yoon Ong, Ana Maybank, Rosslyn Waterman, Paige Rohrbeck, Patricia Julius, Michael Roth, Amanda Martinez, Joshua Nielsen, Lindsey Steele, Eric McGann, Patrick Hinkle, Mary TI The Challenges of Implementing Next Generation Sequencing Across a Large Healthcare System, and the Molecular Epidemiology and Antibiotic Susceptibilities of Carbapenemase-Producing Bacteria in the Healthcare System of the US Department of Defense SO PLOS ONE LA English DT Article ID ANTIMICROBIAL RESISTANCE; GENOME; QUALITY; PROGRAM; TIME AB Methods All phenotypically carbapenem resistant bacteria underwent CarbaNP (R) testing and PCR, followed by NGS. Commercial (Newbler and Geneious), on-line (ResFinder), and opensource software (Btrim, FLASh, Bowtie2, an Samtools) were used for assembly, SNP detection and clustering. Laboratory capacity, throughput, and response time were assessed. Results From 2009 through 2015, 27,000 multidrug-resistant Gram-negative isolates were submitted. 225 contained carbapenemase-encoding genes (most commonly bla(KPC), bla(NDM), and bla(OXA23)). These were found in 15 species from 146 inpatients in 19 facilities. Genetically related CPB were found in more than one hospital. Other clusters or outbreaks were not clonal and involved genetically related plasmids, while some involved several unrelated plasmids. Relatedness depended on the clustering algorithm used. Transmission patterns of plasmids and other mobile genetic elements could not be determined without ultra-long read, single-molecule real-time sequencing. 80% of carbapenem-resistant phenotypes retained susceptibility to aminoglycosides, and 70% retained susceptibility to fluoroquinolones. However, among the CPB-confirmed genotypes, fewer than 25% retained susceptibility to aminoglycosides or fluoroquinolones. Conclusion Although NGS is increasingly acclaimed to revolutionize clinical practice, resource-constrained environments, large or geographically dispersed healthcare networks, and military or government-funded public health laboratories are likely to encounter constraints and challenges as they implement NGS across their health systems. These include lack of standardized definitions and quality control metrics, limitations of short-read sequencing, insufficient bandwidth, and the current limited availability of very expensive and scarcely available sequencing platforms. Possible solutions and mitigations are also proposed. C1 [Lesho, Emil; Clifford, Robert; Onmus-Leone, Fatma; Appalla, Lakshmi; Snesrud, Erik; Kwak, Yoon; Ong, Ana; Maybank, Rosslyn; Julius, Michael; Roth, Amanda; Martinez, Joshua; McGann, Patrick; Hinkle, Mary] Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Antimicrobial Resistance Monitoring & Res ARMoR P, Silver Spring, MD USA. [Waterman, Paige] Armed Forces Hlth Surveillance Sect, Global Emerging Infect Dis Surveillance & Respons, Silver Spring, MD USA. [Rohrbeck, Patricia] Armed Forces Hlth Surveillance Ctr, Epidemiol & Anal Sect, Silver Spring, MD USA. [Nielsen, Lindsey; Steele, Eric] San Antonio Mil Med Ctr, Dept Lab Med, San Antonio, TX USA. RP Lesho, E (reprint author), Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Antimicrobial Resistance Monitoring & Res ARMoR P, Silver Spring, MD USA. EM carolinelesho@yahoo.com FU Global Emerging Infection Surveillance System, Armed Forces Health Surveillance Center; U.S. Army Medical Command FX This work was supported by the Global Emerging Infection Surveillance System, Armed Forces Health Surveillance Center and the U.S. Army Medical Command. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 21 TC 0 Z9 0 U1 3 U2 6 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAY 19 PY 2016 VL 11 IS 5 AR e0155770 DI 10.1371/journal.pone.0155770 PG 12 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DM4BR UT WOS:000376291100098 PM 27196272 ER PT J AU Joachim, A Bauer, A Joseph, S Geldmacher, C Munseri, PJ Aboud, S Missanga, M Mann, P Wahren, B Ferrari, G Polonis, VR Robb, ML Weber, J Tatoud, R Maboko, L Hoelscher, M Lyamuya, EF Biberfeld, G Sandstrom, E Kroidl, A Bakari, M Nilsson, C McCormack, S AF Joachim, Agricola Bauer, Asli Joseph, Sarah Geldmacher, Christof Munseri, Patricia J. Aboud, Said Missanga, Marco Mann, Philipp Wahren, Britta Ferrari, Guido Polonis, Victoria R. Robb, Merlin L. Weber, Jonathan Tatoud, Roger Maboko, Leonard Hoelscher, Michael Lyamuya, Eligius F. Biberfeld, Gunnel Sandstrom, Eric Kroidl, Arne Bakari, Muhammad Nilsson, Charlotta McCormack, Sheena TI Boosting with Subtype C CN54rgp140 Protein Adjuvanted with Glucopyranosyl Lipid Adjuvant after Priming with HIV-DNA and HIV-MVA Is Safe and Enhances Immune Responses: A Phase I Trial SO PLOS ONE LA English DT Article ID VACCINIA VIRUS ANKARA; EFFICACY TRIAL; DOUBLE-BLIND; HEALTHY-ADULTS; VACCINATION; BROAD; IMMUNOGENICITY; INFECTION; TANZANIA; THAILAND AB Background A vaccine against HIV is widely considered the most effective and sustainable way of reducing new infections. We evaluated the safety and impact of boosting with subtype C CN54rgp140 envelope protein adjuvanted in glucopyranosyl lipid adjuvant (GLA-AF) in Tanzanian volunteers previously given three immunizations with HIV-DNA followed by two immunizations with recombinant modified vaccinia virus Ankara (HIV-MVA). Methods Forty volunteers (35 vaccinees and five placebo recipients) were given two CN54rgp140/GLA-AF immunizations 30-71 weeks after the last HIV-MVA vaccination. These immunizations were delivered intramuscularly four weeks apart. Results The vaccine was safe and well tolerated except for one episode of asymptomatic hypoglycaemia that was classified as severe adverse event. Two weeks after the second HIV-MVA vaccination 34 (97%) of the 35 previously vaccinated developed Env-specific binding antibodies, and 79% and 84% displayed IFN-gamma ELISpot responses to Gag and Env, respectively. Binding antibodies to subtype C Env (included in HIV-DNA and protein boost), subtype B Env (included only in HIV-DNA) and CRF01_AE Env (included only in HIV-MVA) were significantly boosted by the CN54rgp140/GLA-AF immunizations. Functional antibodies detected using an infectious molecular clone virus/peripheral blood mononuclear cell neutralization assay, a pseudovirus/TZM-bl neutralization assay or by assays for antibody-dependent cellular cytotoxicity (ADCC) were not significantly boosted. In contrast, T-cell proliferative responses to subtype B MN antigen and IFN-gamma ELISpot responses to Env peptides were significantly enhanced. Four volunteers not primed with HIV-DNA and HIV-MVA before the CN54rgp140/ GLA-AF immunizations mounted an antibody response, while cell-mediated responses were rare. After the two Env subtype C protein immunizations, a trend towards higher median subtype C Env binding antibody titers was found in vaccinees who had received HIV-DNA and HIV-MVA prior to the two Env protein immunizations as compared to unprimed vaccinees (p = 0.07). Conclusion We report excellent tolerability, enhanced binding antibody responses and Env-specific cell-mediated immune responses but no ADCC antibody increase after two immunizations with a subtype C rgp140 protein adjuvanted in GLA-AF in healthy volunteers previously immunized with HIV-DNA and HIV-MVA. C1 [Joachim, Agricola; Aboud, Said; Lyamuya, Eligius F.] Muhimbili Univ Hlth & Allied Sci, Dept Microbiol & Immunol, Dar Es Salaam, Tanzania. [Joachim, Agricola; Wahren, Britta; Biberfeld, Gunnel; Nilsson, Charlotta] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden. [Bauer, Asli; Missanga, Marco; Mann, Philipp; Maboko, Leonard; Hoelscher, Michael; Kroidl, Arne] Natl Inst Med Res Mbeya, Med Res Ctr, Mbeya, Tanzania. [Bauer, Asli; Geldmacher, Christof; Hoelscher, Michael; Kroidl, Arne] Univ Munich LMU, Med Ctr, Dept Infect Dis & Trop Med, Munich, Germany. [Joseph, Sarah; McCormack, Sheena] UCL, MRC, Clin Trials Unit, London, England. [Geldmacher, Christof; Hoelscher, Michael; Kroidl, Arne] German Ctr Infect Res DZIF, Partner Site Munich, Munich, Germany. [Munseri, Patricia J.; Bakari, Muhammad] Muhimbili Univ Hlth & Allied Sci, Dept Internal Med, Dar Es Salaam, Tanzania. [Ferrari, Guido] Duke Univ, Med Ctr, Dept Surg & Mol Genet & Microbiol, Durham, NC USA. [Polonis, Victoria R.; Robb, Merlin L.] Walter Reed Army Inst Res, Mil HIV Res Program, Silver Spring, MD USA. [Robb, Merlin L.] Henry M Jackson Fdn Adv Mil Med, Mil HIV Res Program, Bethesda, MD USA. [Weber, Jonathan; Tatoud, Roger] Univ London Imperial Coll Sci Technol & Med, London, England. [Sandstrom, Eric] Soder Sjukhuset, Karolinska Insitutet, Venhalsan, S-10064 Stockholm, Sweden. [Nilsson, Charlotta] Publ Hlth Agcy Sweden, Solna, Sweden. [Nilsson, Charlotta] Karolinska Inst Huddinge, Dept Lab Med, Stockholm, Sweden. [Mann, Philipp] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, 1124 Columbia St, Seattle, WA 98104 USA. [Tatoud, Roger] Chelsea & Westminster NHS Fdn Trust, St Stephens Ctr, Int AIDS Vaccine Initiat IAVI, London, England. RP Joachim, A (reprint author), Muhimbili Univ Hlth & Allied Sci, Dept Microbiol & Immunol, Dar Es Salaam, Tanzania.; Joachim, A (reprint author), Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden. EM agricola.joachim@ki.se RI Hoelscher, Michael/D-3436-2012 FU European and Developing Countries Clinical Trials Partnership (EDCTP) [CT.2006.33111.007, CT.2006.33111.001]; German Ministry of Education and Research (BMBF) [01KA0802]; Swedish International Development Cooperation Agency (Sida); Swedish Embassy in Tanzania; CAVD [1032144]; Duke University Center for AIDS Research (CFAR) Grant [P30 AI64518]; US Military HIV Research program, Walter Reed Army Institute of Research (WRAIR); UKHVC - Wellcome Trust [083844/Z/07/Z]; Public Health Agency of Sweden; MUHAS; Regional HIV/AIDS Team for Africa at the Embassy of Sweden in Lusaka - Sweden [2150012801]; Regional HIV/AIDS Team for Africa at the Embassy of Sweden in Lusaka - Norway [2150012801] FX The Swedish Institute for Communicable Disease Control (currently the Public Health Agency of Sweden) and MUHAS sponsored the trial. Financial support for the trial was received from the European and Developing Countries Clinical Trials Partnership (EDCTP) for two grants (Grant ID CT.2006.33111.007 and CT.2006.33111.001), the German Ministry of Education and Research (BMBF, Grant ID: 01KA0802), the Swedish International Development Cooperation Agency (Sida), the Swedish Embassy in Tanzania and the Regional HIV/AIDS Team for Africa at the Embassy of Sweden in Lusaka jointly funded by Sweden and Norway (Sida contribution no. 2150012801). This study was partially supported by a technology transfer through the CAVD (Grant ID: 1032144) and Duke University Center for AIDS Research (CFAR) Grant (P30 AI64518), the US Military HIV Research program, Walter Reed Army Institute of Research (WRAIR) and through the UKHVC funded by the Wellcome Trust (Grant award no. 083844/Z/07/Z). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 30 TC 1 Z9 1 U1 1 U2 1 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAY 18 PY 2016 VL 11 IS 5 AR e0155702 DI 10.1371/journal.pone.0155702 PG 18 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DM3ZU UT WOS:000376286100083 PM 27192151 ER PT J AU Graves, SF Kouriba, B Diarra, I Daou, M Niangaly, A Coulibaly, D Keita, Y Laurens, MB Berry, AA Vekemans, J Ballou, WR Lanar, DE Dutta, S Heppner, DG Soisson, L Diggs, CL Thera, MA Doumbo, OK Plowe, CV Sztein, MB Lyke, KE AF Graves, Shawna F. Kouriba, Bourema Diarra, Issa Daou, Modibo Niangaly, Amadou Coulibaly, Drissa Keita, Yamoussa Laurens, Matthew B. Berry, Andrea A. Vekemans, Johan Ballou, W. Ripley Lanar, David E. Dutta, Sheetij Heppner, D. Gray Soisson, Lorraine Diggs, Carter L. Thera, Mahamadou A. Doumbo, Ogobara K. Plowe, Christopher V. Sztein, Marcelo B. Lyke, Kirsten E. TI Strain-specific Plasmodium falciparum multifunctional CD4(+) T cell cytokine expression in Malian children immunized with the FMP2.1/AS02(A) vaccine candidate SO VACCINE LA English DT Article DE Malaria; Pediatric; T cell; Multifunctional; AMA1; FMP2.1/AS02(A) ID APICAL MEMBRANE ANTIGEN-1; BLOOD-STAGE MALARIA; MEDIATED-IMMUNITY; PROTECTIVE IMMUNITY; GENETIC DIVERSITY; SURFACE-ANTIGEN; INFECTION; ADULTS; IMMUNOGENICITY; EFFICACY AB Based on Plasmodium falciparum (Pf) apical membrane antigen 1 (AMA1) from strain 3D7, the malaria vaccine candidate FMP2.1/AS02(A) showed strain-specific efficacy in a Phase 2 clinical trial in 400 Malian children randomized to 3 doses of the AMA1 vaccine candidate or control rabies vaccine on days 0, 30 and 60. A subset of 10 Pf(-) (i.e., no clinical malaria episodes) AMA1 recipients, 11 Pf(+) (clinical malaria episodes with parasites with 3D7 or Fab9-type AMA1 cluster 1 loop [c1L]) AMA1 recipients, and 10 controls were randomly chosen for analysis. Peripheral blood mononuclear cells (PBMCs) isolated on days 0, 90 and 150 were stimulated with full-length 3D7 AMA1 and c1L from strains 3D7 (c3D7) and Fab9 (cFab9). Production of IFN-gamma, TNF-alpha, IL-2, and/or IL-17A was analyzed by flow cytometry. Among AMA1 recipients, 18/21 evaluable samples stimulated with AMA1 demonstrated increased IFN-gamma, TNF-alpha, and IL-2 derived from CD4(+) T cells by day 150 compared to 0/10 in the control group (p < 0.0001). Among AMA1 vaccines, CD4(+) cells expressing both TNF-alpha and IL-2 were increased in Pf(-) children compared to Pf(+) children. When PBMCs were stimulated with c3D7 and cFab9 separately, 4/18 AMA1 recipients with an AMA1-specific CD4(+) response had a significant response to one or both c1L. This suggests that recognition of the AMA1 antigen is not dependent upon c1L alone. In summary, AMA1-specific T cell responses were notably increased in children immunized with an AMA1-based vaccine candidate. The role of CD4(+)TNF-alpha IL-2(+)-expressing T cells in vaccine-induced strain-specific protection against clinical malaria requires further exploration. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Graves, Shawna F.; Laurens, Matthew B.; Berry, Andrea A.; Plowe, Christopher V.; Sztein, Marcelo B.; Lyke, Kirsten E.] Univ Maryland, Sch Med, Ctr Vaccine Dev, 685 W Baltimore St,HSF 1 Room 480, Baltimore, MD 21201 USA. [Kouriba, Bourema; Diarra, Issa; Daou, Modibo; Niangaly, Amadou; Coulibaly, Drissa; Keita, Yamoussa; Thera, Mahamadou A.; Doumbo, Ogobara K.] Univ Sci Techn & Technol, Malaria Res & Training Ctr, Bamako, Mali. [Laurens, Matthew B.; Berry, Andrea A.; Plowe, Christopher V.] Univ Maryland, Howard Hughes Med Inst, Baltimore, MD 21201 USA. [Vekemans, Johan; Ballou, W. Ripley] GlaxoSmithKline Vaccines, Rixensart, Belgium. [Lanar, David E.; Dutta, Sheetij; Heppner, D. Gray] Walter Reed Army Inst Res, Mil Malaria Res Program, Silver Spring, MD USA. [Soisson, Lorraine; Diggs, Carter L.] US Agcy Int Dev, Malaria Vaccine Dev Program, Washington, DC 20523 USA. RP Lyke, KE (reprint author), Univ Maryland, Sch Med, Ctr Vaccine Dev, 685 W Baltimore St,HSF 1 Room 480, Baltimore, MD 21201 USA. EM klyke@medicine.umaryland.edu RI Laurens, Matthew/E-7293-2013 OI Laurens, Matthew/0000-0003-3874-581X FU National Institute of Allergy and Infectious Diseases [N01AI85346, U19AI065683]; Fogarty International Center, National Institutes of Health [D43TW001589]; United States Department of Defense [W81XWH-06-1-0427]; United States Agency for International Development; United States Agency for International Development, Washington, D.C.; Military Infectious Diseases Research Program, Fort Detrick, MD; International Collaboration on Infectious Diseases Research [U01AI065683-06]; Howard Hughes Medical Institute FX We would like to thank the people of Bandiagara, Mali for their participation and support of this vaccine study. The Walter Reed Army Institute of Research (WRAIR) kindly provided the purified recombinant AMA1-derived protein FMP2.1 used for cellular stimulation and formed the basis of the FMP2.1/AS02A vaccine candidate for this study. Additionally, we would like to thank GlaxoSmithKline Vaccines for providing the AS02A adjuvant. The conduct of the trial was supported by a contract N01AI85346 and a cooperative agreement U19AI065683 from the National Institute of Allergy and Infectious Diseases, grant D43TW001589 from the Fogarty International Center, National Institutes of Health and contract W81XWH-06-1-0427 from the United States Department of Defense and the United States Agency for International Development. Vaccine production was supported by the United States Agency for International Development, Washington, D.C. and by the Military Infectious Diseases Research Program, Fort Detrick, MD. The immunologic assays and SG were funded by contract U01AI065683-06 from the International Collaboration on Infectious Diseases Research. CVP and MBL are supported by the Howard Hughes Medical Institute. This abstract was presented in part to the American Society of Tropical Medicine and Hygiene, Washington, D.C., November 2013, abstract #1443. NR 42 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD MAY 17 PY 2016 VL 34 IS 23 BP 2546 EP 2555 DI 10.1016/j.vaccine.2016.04.019 PG 10 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA DM9SC UT WOS:000376705000004 PM 27087149 ER PT J AU Howell, KA Qiu, XG Brannan, JM Bryan, C Davidson, E Holtsberg, FW Wec, AZ Shulenin, S Biggins, JE Douglas, R Enterlein, SG Turner, HL Pallesen, J Murin, CD He, SH Kroeker, A Vu, H Herbert, AS Fusco, ML Nyakatura, EK Lai, JR Keck, ZY Foung, SKH Saphire, EO Zeitlin, L Ward, AB Chandran, K Doranz, BJ Kobinger, GP Dye, JM Aman, MJ AF Howell, Katie A. Qiu, Xiangguo Brannan, Jennifer M. Bryan, Christopher Davidson, Edgar Holtsberg, Frederick W. Wec, Anna Z. Shulenin, Sergey Biggins, Julia E. Douglas, Robin Enterlein, Sven G. Turner, Hannah L. Pallesen, Jesper Murin, Charles D. He, Shihua Kroeker, Andrea Vu, Hong Herbert, Andrew S. Fusco, Marnie L. Nyakatura, Elisabeth K. Lai, Jonathan R. Keck, Zhen-Yong Foung, Steven K. H. Saphire, Erica Ollmann Zeitlin, Larry Ward, Andrew B. Chandran, Kartik Doranz, Benjamin J. Kobinger, Gary P. Dye, John M. Aman, M. Javad TI Antibody Treatment of Ebola and Sudan Virus Infection via a Uniquely Exposed Epitope within the Glycoprotein Receptor-Binding Site SO CELL REPORTS LA English DT Article ID NIEMANN-PICK C1; MONOCLONAL-ANTIBODIES; NONHUMAN-PRIMATES; MOLECULAR CHARACTERIZATION; NEUTRALIZING ANTIBODY; FILOVIRUS ENTRY; MARBURG VIRUS; GUINEA-PIG; DISEASE; PROPHYLAXIS AB Previous efforts to identify cross-neutralizing antibodies to the receptor-binding site (RBS) of ebolavirus glycoproteins have been unsuccessful, largely because the RBS is occluded on the viral surface. We report a monoclonal antibody (FVM04) that targets a uniquely exposed epitope within the RBS; cross-neutralizes Ebola (EBOV), Sudan (SUDV), and, to a lesser extent, Bundibugyo viruses; and shows protection against EBOV and SUDV in mice and guinea pigs. The antibody cocktail ZMapp (TM) is remarkably effective against EBOV (Zaire) but does not cross-neutralize other ebolaviruses. By replacing one of the ZMapp (TM) components with FVM04, we retained the anti-EBOV efficacy while extending the breadth of protection to SUDV, thereby generating a cross-protective antibody cocktail. In addition, we report several mutations at the base of the ebolavirus glycoprotein that enhance the binding of FVM04 and other cross-reactive antibodies. These findings have important implications for pan-ebolavirus vaccine development and defining broadly protective antibody cocktails. C1 [Howell, Katie A.; Holtsberg, Frederick W.; Shulenin, Sergey; Biggins, Julia E.; Douglas, Robin; Enterlein, Sven G.; Vu, Hong; Aman, M. Javad] Integrated BioTherapeut Inc, Gaithersburg, MD 20878 USA. [Qiu, Xiangguo; He, Shihua; Kroeker, Andrea; Kobinger, Gary P.] Publ Hlth Agcy Canada, Natl Microbiol Lab, Special Pathogens Program, Winnipeg, MB R3E 3R2, Canada. [Qiu, Xiangguo; He, Shihua; Kroeker, Andrea; Kobinger, Gary P.] Univ Manitoba, Dept Med Microbiol, Winnipeg, MB R3E 0J9, Canada. [Qiu, Xiangguo; He, Shihua; Kroeker, Andrea; Kobinger, Gary P.] Univ Manitoba, Dept Immunol, Winnipeg, MB R3E 0J9, Canada. [Brannan, Jennifer M.; Herbert, Andrew S.; Dye, John M.] US Army Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Bryan, Christopher; Davidson, Edgar; Doranz, Benjamin J.] Integral Mol, Philadelphia, PA 19104 USA. [Turner, Hannah L.; Pallesen, Jesper; Murin, Charles D.; Ward, Andrew B.] Scripps Res Inst, Dept Integrat Struct & Computat Biol, La Jolla, CA 92037 USA. [Murin, Charles D.; Fusco, Marnie L.; Saphire, Erica Ollmann] Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA. [Saphire, Erica Ollmann] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA. [Wec, Anna Z.; Chandran, Kartik] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA. [Nyakatura, Elisabeth K.; Lai, Jonathan R.] Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA. [Keck, Zhen-Yong; Foung, Steven K. H.] Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA. [Zeitlin, Larry] Mapp Biopharmaceut, San Diego, CA 92121 USA. RP Aman, MJ (reprint author), Integrated BioTherapeut Inc, Gaithersburg, MD 20878 USA. EM javad@integratedbiotherapeutics.com RI Ward, Andrew/F-9203-2014 OI Ward, Andrew/0000-0001-7153-3769 FU U.S. Defense Threat Reduction Agency (DTRA) [HDTRA1-13-C-0015]; NIH [U19 AI109762, HHSN272201400058C, U19AI109762]; Public Health Agency of Canada (PHAC); National Science Foundation; DAAD (Deutscher Akademischer Austauschdienst [German Academic Exchange Service]) fellowship FX This work was supported by a contract (HDTRA1-13-C-0015) from the U.S. Defense Threat Reduction Agency (DTRA) to M.J.A., grant U19 AI109762 from the NIH to E.O.S., and NIH contract HHSN272201400058C to B.J.D. J.R.L. acknowledges funding from the NIH (U19AI109762). This work was also partially supported by the Public Health Agency of Canada (PHAC). We thank Andrew McNeal and Rachel Fong for valuable technical assistance. C.D.M. is supported by a pre-doctoral fellowship from the National Science Foundation. E.K.N. was supported by a DAAD (Deutscher Akademischer Austauschdienst [German Academic Exchange Service]) fellowship. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army. M.J.A. is a shareholder of Integrated Biotherapeutics. S.G.E., F.W.H., H.V., R.D., and S.S. own stock options in Integrated Biotherapeutics. NR 52 TC 7 Z9 7 U1 7 U2 19 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 2211-1247 J9 CELL REP JI Cell Reports PD MAY 17 PY 2016 VL 15 IS 7 BP 1514 EP 1526 DI 10.1016/j.celrep.2016.04.026 PG 13 WC Cell Biology SC Cell Biology GA DM2GO UT WOS:000376165300015 PM 27160900 ER PT J AU Jin, XN Potter, B Luong, TL Nelson, J Vuong, C Potter, C Xie, LS Zhang, J Zhang, P Sousa, J Li, QG Pybus, BS Kreishman-Deitrick, M Hickman, M Smith, PL Paris, R Reichard, G Marcsisin, SR AF Jin, Xiannu Potter, Brittney Luong, Thu-lan Nelson, Jennifer Chau Vuong Potter, Corttney Xie, Lisa Zhang, Jing Zhang, Ping Sousa, Jason Li, Qigui Pybus, Brandon S. Kreishman-Deitrick, Mara Hickman, Mark Smith, Philip L. Paris, Robert Reichard, Gregory Marcsisin, Sean R. TI Pre-clinical evaluation of CYP 2D6 dependent drug-drug interactions between primaquine and SSRI/SNRI antidepressants SO MALARIA JOURNAL LA English DT Article DE Primaquine; Antimalarial; Drug metabolism; Pharmacokinetics; CYP 2D6; Relapsing malaria; Drug-drug interactions ID SEROTONIN REUPTAKE INHIBITORS; ADULT THAI SUBJECTS; VIVAX MALARIA; PLASMA-CONCENTRATIONS; IN-VITRO; METABOLISM; PHARMACOKINETICS; VENLAFAXINE; FLUOXETINE; RESISTANCE AB Background: The liver-stage anti-malarial activity of primaquine and other 8-aminoquinoline molecules has been linked to bio-activation through CYP 2D6 metabolism. Factors such as CYP 2D6 poor metabolizer status and/or co-administration of drugs that inhibit/interact with CYP 2D6 could alter the pharmacological properties of primaquine. Methods: In the present study, the inhibitory potential of the selective serotonin reuptake inhibitor (SSRI) and serotonin norepinephrine reuptake inhibitor (SNRI) classes of antidepressants for CYP 2D6-mediated primaquine metabolism was assessed using in vitro drug metabolism and in vivo pharmacological assays. Results: The SSRI/SNRI classes of drug displayed a range of inhibitory activities on CYP 2D6-mediated metabolism of primaquine in vitro (IC50 1-94 mu M). Fluoxetine and paroxetine were the most potent inhibitors (IC50 similar to 1 mu M) of CYP 2D6-mediated primaquine metabolism, while desvenlafaxine was the least potent (IC50 similar to 94 mu M). The most potent CYP 2D6 inhibitor, fluoxetine, was chosen to investigate the potential pharmacological consequences of co-administration with primaquine in vivo. The pharmacokinetics of a CYP 2D6-dependent primaquine metabolite were altered upon co-administration with fluoxetine. Additionally, in a mouse malaria model, co-administration of fluoxetine with primaquine reduced primaquine anti-malarial efficacy. Conclusions: These results are the first from controlled pre-clinical experiments that indicate that primaquine pharmacological properties can be modulated upon co-incubation/administration with drugs that are known to interact with CYP 2D6. These results highlight the potential for CYP 2D6-mediated drug-drug interactions with primaquine and indicate that the SSRI/SNRI antidepressants could be used as probe molecules to address the primaquine-CYP 2D6 DDI link in clinical studies. Additionally, CYP 2D6-mediated drug-drug interactions can be considered when examining the possible causes of human primaquine therapy failures. C1 [Jin, Xiannu; Potter, Brittney; Luong, Thu-lan; Nelson, Jennifer; Chau Vuong; Potter, Corttney; Xie, Lisa; Zhang, Jing; Zhang, Ping; Sousa, Jason; Li, Qigui; Pybus, Brandon S.; Kreishman-Deitrick, Mara; Hickman, Mark; Smith, Philip L.; Paris, Robert; Reichard, Gregory; Marcsisin, Sean R.] Walter Reed Army Inst Res, Mil Malaria Res Program, Expt Therapeut Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. RP Marcsisin, SR (reprint author), Walter Reed Army Inst Res, Mil Malaria Res Program, Expt Therapeut Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM sean.r.marcsisin.mil@mail.mil FU Military Infectious Diseases Research Program (MIDRP) project [Q0302_12_WR_CS] FX This work was supported by the Military Infectious Diseases Research Program (MIDRP) project # Q0302_12_WR_CS. We would like to thank Dr. Larry Walker, Dr. Babu Tekwani, Dr. Jim McChesney, and Dr. David Jollow for their scientific guidance and suggestions. This material has been NR 36 TC 0 Z9 0 U1 2 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD MAY 17 PY 2016 VL 15 AR 280 DI 10.1186/s12936-016-1329-z PG 10 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA DM0XC UT WOS:000376068200002 PM 27188854 ER PT J AU Anquillare, EL Miller, OD Hsu, CW DeLacy, BG Joannopoulos, JD Johnson, SG Soljacic, M AF Anquillare, E. L. Miller, O. D. Hsu, C. W. DeLacy, B. G. Joannopoulos, J. D. Johnson, S. G. Soljacic, M. TI Efficient, designable, and broad-bandwidth optical extinction via aspect-ratio-tailored silver nanodisks SO OPTICS EXPRESS LA English DT Article ID GOLD NANOPARTICLES; PLASMON RESPONSE; LIGHT-ABSORPTION; SOLAR-CELLS; SHAPE; NANOSTRUCTURES; OPTIMIZATION; RULES AB Subwavelength resonators, ranging from single atoms to metallic nanoparticles, typically exhibit a narrow-bandwidth response to optical excitations. We computationally design and experimentally synthesize tailored distributions of silver nanodisks to extinguish light over broad and varied frequency windows. We show that metallic nanodisks are 2-10x more efficient in absorbing and scattering light than common structures, and can approach fundamental limits to broadband scattering for subwavelength particles. We measure broadband extinction per volume that closely approaches theoretical predictions over three representative visible-range wavelength windows, confirming the high efficiency of nanodisks and demonstrating the collective power of computational design and experimental precision for developing new photonics technologies. (C) 2016 Optical Society of America C1 [Anquillare, E. L.; Hsu, C. W.; Joannopoulos, J. D.; Soljacic, M.] MIT, Dept Phys, Cambridge, MA 02139 USA. [Miller, O. D.; Johnson, S. G.] MIT, Dept Math, Cambridge, MA 02139 USA. [Hsu, C. W.] Yale Univ, Dept Appl Phys, New Haven, CT 06520 USA. [DeLacy, B. G.] US Army, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Anquillare, EL (reprint author), MIT, Dept Phys, Cambridge, MA 02139 USA. EM eanquill@mit.edu RI Hsu, Chia Wei/G-5486-2011 OI Hsu, Chia Wei/0000-0002-9609-7155 FU U. S. Army Research Laboratory; U. S. Army Research Office through the Institute for Soldier Nanotechnologies [W911NF-13-D-0001]; MRSEC Program National Science Foundation (NSF) [DMR-1419807]; MIT Deshpande Center for Technological Innovation FX We thank Yong Zhang & Tim McClure for instrumentation assistance. This work was supported by the U. S. Army Research Laboratory and the U. S. Army Research Office through the Institute for Soldier Nanotechnologies under contract number W911NF-13-D-0001). It was also supported in part by MRSEC Program of the National Science Foundation (NSF) under contract DMR-1419807 and the MIT Deshpande Center for Technological Innovation. NR 51 TC 0 Z9 0 U1 1 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD MAY 16 PY 2016 VL 24 IS 10 AR 261563 DI 10.1364/OE.24.010806 PG 11 WC Optics SC Optics GA DM5IE UT WOS:000376380700082 PM 27409901 ER PT J AU Goupil, BA McNulty, MA Martin, MJ McCracken, MK Christofferson, RC Mores, CN AF Goupil, Brad A. McNulty, Margaret A. Martin, Matthew J. McCracken, Michael K. Christofferson, Rebecca C. Mores, Christopher N. TI Novel Lesions of Bones and Joints Associated with Chikungunya Virus Infection in Two Mouse Models of Disease: New Insights into Disease Pathogenesis SO PLOS ONE LA English DT Article ID RHEUMATOID-ARTHRITIS; INBRED STRAINS; INFLAMMATORY DISEASE; CARTILAGE REPAIR; MARROW NECROSIS; REUNION ISLAND; MICE; ARTHRALGIA; MICROSTRUCTURE; MANIFESTATIONS AB Chikungunya virus is an arbovirus spread predominantly by Aedes aegypti and Ae. albopictus mosquitoes, and causes debilitating arthralgia and arthritis. While these are common manifestations during acute infection and it has been suggested they can recur in patients chronically, gaps in knowledge regarding the pathogenesis still exist. Two established mouse models were utilized (adult IRF 3/7(-/-) (-/-) and wild-type C57BL/6J mice) to evaluate disease manifestations in bones and joints at various timepoints. Novel lesions in C57BL/6J mice consisted of periostitis (91%) and foci of cartilage of necrosis (50% of mice at 21 DPI). Additionally, at 21 DPI, 50% and 75% of mice exhibited periosteal bone proliferation affecting the metatarsal bones, apparent via histology and mu CT, respectively. mu CT analysis did not reveal any alterations in trabecular bone volume measurements in C57BL/6J mice. Novel lesions demonstrated in IRF 3/7(-/-) (-/-) mice at 5 DPI included focal regions of cartilage necrosis (20%), periosteal necrosis (66%), and multifocal ischemic bone marrow necrosis (100%). Contralateral feet in 100% of mice of both strains had similar, though milder lesions. Additionally, comparison of control IRF 3/7(-/-) (-/-) and wild-type C57BL/6J mice demonstrated differences in cortical bone. These experiments demonstrate novel manifestations of disease similar to those occurring in humans, adding insight into disease pathogenesis, and representing new potential targets for therapeutic interventions. Additionally, results demonstrate the utility of mu CT in studies of bone and joint pathology and illustrate differences in bone dynamics between mouse strains. C1 [Goupil, Brad A.; McCracken, Michael K.; Christofferson, Rebecca C.; Mores, Christopher N.] Louisiana State Univ, Sch Vet Med, Dept Pathobiol Sci, Skip Bertman Dr, Baton Rouge, LA 70803 USA. [McNulty, Margaret A.; Martin, Matthew J.] Louisiana State Univ, Sch Vet Med, Dept Comparat Biomed Sci, Skip Bertman Dr, Baton Rouge, LA 70803 USA. [McCracken, Michael K.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD USA. RP Goupil, BA (reprint author), Louisiana State Univ, Sch Vet Med, Dept Pathobiol Sci, Skip Bertman Dr, Baton Rouge, LA 70803 USA. EM bgoupi1@lsu.edu FU National Institutes of Health Centers of Biomedical Research Excellence (COBRE) Phase III Award [1P30GM110760-01]; T32 training grant [5T32OD011124-09]; Louisiana Board of Regents Traditional Enhancement Grant LEQSF [(2013-14)-ENH-TR-06] FX This work is supported by the National Institutes of Health Centers of Biomedical Research Excellence (COBRE) Phase III Award 1P30GM110760-01 to CNM and T32 training grant 5T32OD011124-09 to BAG, and a Louisiana Board of Regents Traditional Enhancement Grant LEQSF (2013-14)-ENH-TR-06 to MAM. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 62 TC 2 Z9 2 U1 1 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAY 16 PY 2016 VL 11 IS 5 AR e0155243 DI 10.1371/journal.pone.0155243 PG 21 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DM3XH UT WOS:000376279500030 PM 27182740 ER PT J AU Matters, DA Lerch, AG Hurst, AM Szentmiklosi, L Carroll, JJ Detwiler, B Revay, Z McClory, JW McHale, SR Firestone, RB Sleaford, BW Krticka, M Belgya, T AF Matters, D. A. Lerch, A. G. Hurst, A. M. Szentmiklosi, L. Carroll, J. J. Detwiler, B. Revay, Zs. McClory, J. W. McHale, S. R. Firestone, R. B. Sleaford, B. W. Krticka, M. Belgya, T. TI Investigation of Re-186 via radiative thermal-neutron capture on Re-185 SO PHYSICAL REVIEW C LA English DT Article ID GAMMA ACTIVATION-ANALYSIS; BUDAPEST RESEARCH REACTOR; CROSS-SECTIONS; NUCLEAR-DATA; RESONANCES; STRENGTH; STANDARDIZATION; WIDTHS; PGAA AB Partial gamma-ray production cross sections and the total radiative thermal-neutron capture cross section for the Re-185(n,gamma) Re-186 reaction were measured using the Prompt Gamma Activation Analysis facility at the Budapest Research Reactor with an enriched Re-185 target. The Re-186 cross sections were standardized using well-known Cl-35(n,gamma) Cl-36 cross sections from irradiation of a stoichiometric (ReCl3)-Re-nat target. The resulting cross sections for transitions feeding the Re-186 ground state from low-lying levels below a cutoff energy of E-c = 746 keV were combined with a modeled probability of ground-state feeding from levels above E-c to arrive at a total cross section of sigma(0) = 111(6) b for radiative thermal-neutron capture on Re-185. A comparison of modeled discrete-level populations with measured transition intensities led to proposed revisions for seven tentative spin-parity assignments in the adopted level scheme for Re-186. Additionally, 102 primary gamma rays were measured, including 50 previously unknown. A neutron-separation energy of S-n = 6179.59(5) keV was determined from a global least-squares fit of the measured gamma-ray energies to the known Re-186 decay scheme. The total capture cross section and separation energy results are comparable to earlier measurements of these values. C1 [Matters, D. A.; McClory, J. W.] US Air Force, Inst Technol, Wright Patterson AFB, OH 45433 USA. [Lerch, A. G.; McHale, S. R.] Def Threat Reduct Agcy, Ft Belvoir, VA 22060 USA. [Hurst, A. M.; Firestone, R. B.] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA. [Hurst, A. M.] Univ Calif Berkeley, Dept Nucl Engn, Berkeley, CA 94720 USA. [Szentmiklosi, L.; Belgya, T.] Hungarian Acad Sci, Ctr Energy Res, H-1525 Budapest, Hungary. [Carroll, J. J.] US Army Res Lab, Adelphi, MD 20783 USA. [Detwiler, B.] Youngstown State Univ, Youngstown, OH 44555 USA. [Revay, Zs.] Tech Univ Munich, Heinz Maier Leibnitz Zentrum MLZ 7, Garching, Germany. [Sleaford, B. W.] Lawrence Livermore Natl Lab, Livermore, CA 94550 USA. [Krticka, M.] Charles Univ Prague, Fac Math & Phys, CZ-18000 Prague, Czech Republic. RP Matters, DA (reprint author), US Air Force, Inst Technol, Wright Patterson AFB, OH 45433 USA. EM david.a.matters.mil@mail.mil RI Szentmiklosi, Laszlo/F-5362-2015 OI Szentmiklosi, Laszlo/0000-0001-7747-8545 FU Defense Threat Reduction Agency Grant [HDTRA1-08-1-0014]; University of California - Office of Science, Office of Basic Energy Sciences, of the US Department of Energy at the Lawrence Berkeley National Laboratory [DE-AC02-05CH11231]; Office of Science, Office of Basic Energy Sciences, of the US Department of Energy at Lawrence Livermore National Laboratory [DE-AC52-07NA27344]; Domestic Nuclear Detection Office of the Department of Homeland Security; NAP VENEUS08 grant [OMFB-00184/2006]; Czech Science Foundation [13-07117S] FX This work was initiated under Defense Threat Reduction Agency Grant No. HDTRA1-08-1-0014 (YSU). Later work was performed under the auspices of the University of California, supported by the Director, Office of Science, Office of Basic Energy Sciences, of the US Department of Energy at the Lawrence Berkeley National Laboratory under Contract No. DE-AC02-05CH11231, and at Lawrence Livermore National Laboratory under Contract No. DE-AC52-07NA27344. Additional funding was provided by the Domestic Nuclear Detection Office of the Department of Homeland Security. Access to the Budapest PGAA facility was financially supported by the NAP VENEUS08 grant under Contract No. OMFB-00184/2006. This work was also supported by the Czech Science Foundation under Grant No. 13-07117S. The authors gratefully acknowledge the support of the operations staff at the Budapest Research Reactor. D.M. thanks Dr. C.J. Chiara for help reviewing the manuscript. NR 70 TC 0 Z9 0 U1 8 U2 13 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2469-9985 EI 2469-9993 J9 PHYS REV C JI Phys. Rev. C PD MAY 16 PY 2016 VL 93 IS 5 AR 054319 DI 10.1103/PhysRevC.93.054319 PG 19 WC Physics, Nuclear SC Physics GA DM3NN UT WOS:000376253300001 ER PT J AU Rouhani, S Yori, PP Olortegui, MP Salas, MS Trigoso, DR Mondal, D Bodhidatta, L Platts-Mills, J Samie, A Kabir, F Lima, A Babji, S Mason, CJ Kalam, A Bessong, P Ahmed, T Mduma, E Bhutta, ZA Lima, I Ramdass, R Lang, D George, A Zaidi, AKM Kang, G Houpt, E Kosek, MN AF Rouhani, Saba Yori, Pablo Penataro Olortegui, Maribel Paredes Salas, Mery Siguas Trigoso, Dixner Rengifo Mondal, Dinesh Bodhidatta, Ladaporn Platts-Mills, James Samie, Amidou Kabir, Furqan Lima, Aldo Babji, Sudhir Mason, Carl J. Kalam, Adil Bessong, Pascal Ahmed, Tahmeed Mduma, Estomih Bhutta, Zulfiqar A. Lima, Ila Ramdass, Rakhi Lang, Dennis George, Ajila Zaidi, Anita K. M. Kang, Gagandeep Houpt, Eric Kosek, Margaret N. CA Etiology Risk Factors Interactions TI Norovirus Infection and Acquired Immunity in 8 Countries: Results From the MAL-ED Study SO CLINICAL INFECTIOUS DISEASES LA English DT Article DE norovirus; diarrhea; immunity ID BIRTH COHORT; GASTROENTERITIS; METAANALYSIS; COMMUNITY; CHILDREN AB Background. Norovirus is an important cause of childhood diarrhea. We present data from a longitudinal, multicountry study describing norovirus epidemiology during the first 2 years of life. Methods. A birth cohort of 1457 children across 8 countries contributed 7077 diarrheal stools for norovirus testing. A subset of 199 children contributed additional asymptomatic samples (2307) and diarrheal stools (770), which were used to derive incidence rates and evaluate evidence for acquired immunity. Results. Across sites, 89% of children experienced at least 1 norovirus infection before 24 months, and 22.7% of all diarrheal stools were norovirus positive. Severity of norovirus-positive diarrhea was comparable to other enteropathogens, with the exception of rotavirus. Incidence of genogroup II (GII) infection was higher than genogroup I and peaked at 6-11 months across sites. Undernutrition was a risk factor for symptomatic norovirus infection, with an increase in 1 standard deviation of length-for-age z score associated with a 17% reduction (odds ratio, 0.83 [95% confidence interval, .72-.97]; P = .011) in the odds of experiencing diarrhea when norovirus was present, after accounting for genogroup, rotavirus vaccine, and age. Evidence of acquired immunity was observed among GII infections only: Children with prior GII infection were found to have a 27% reduction in the hazard of subsequent infection (hazard ratio, 0.727; P = .010). Conclusions. The high prevalence of norovirus across 8 sites in highly variable epidemiologic settings and demonstration of protective immunity for GII infections provide support for investment in vaccine development. C1 [Rouhani, Saba; Kosek, Margaret N.] Johns Hopkins Sch Publ Hlth, Baltimore, MD USA. [Yori, Pablo Penataro] Johns Hopkins Univ, Baltimore, MD USA. [Olortegui, Maribel Paredes; Salas, Mery Siguas; Trigoso, Dixner Rengifo] AB PRISMA, Iquitos, Peru. [Mondal, Dinesh; Ahmed, Tahmeed] Icddr B, Dhaka, Bangladesh. [Bodhidatta, Ladaporn; Mason, Carl J.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Platts-Mills, James; Houpt, Eric] Univ Virginia, Charlottesville, VA USA. [Samie, Amidou] Univ Venda, Thohoyandou, South Africa. [Kabir, Furqan; Kalam, Adil; Bessong, Pascal; Bhutta, Zulfiqar A.; Zaidi, Anita K. M.] Aga Khan Univ, Naushahro Feroze, Pakistan. [Lima, Aldo; Lima, Ila] Univ Fed Ceara, Fortaleza, Ceara, Brazil. [Babji, Sudhir; Ramdass, Rakhi; George, Ajila; Kang, Gagandeep] Christian Med Coll & Hosp, Vellore, Tamil Nadu, India. [Mduma, Estomih] Haydom Lutheran Hosp, Haydom, Tanzania. [Lang, Dennis] Fdn Natl Inst Hlth, Bethesda, MD USA. RP Kosek, MN (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Rm E5608,615 N Wolfe St, Baltimore, MD 21205 USA. EM mkosek@jhu.edu RI Strand, Tor/D-9836-2016 OI Strand, Tor/0000-0002-4038-151X NR 15 TC 2 Z9 2 U1 1 U2 1 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD MAY 15 PY 2016 VL 62 IS 10 BP 1210 EP 1220 DI 10.1093/cid/ciw072 PG 11 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA DP3YM UT WOS:000378432100004 PM 27013692 ER PT J AU Stefan, CP Koehler, JW Minogue, TD AF Stefan, Christopher P. Koehler, Jeffrey W. Minogue, Timothy D. TI Targeted next-generation sequencing for the detection of ciprofloxacin resistance markers using molecular inversion probes SO SCIENTIFIC REPORTS LA English DT Article ID POLYMERASE-CHAIN-REACTION; INFECTIOUS-DISEASES; YERSINIA-PESTIS; CLINICAL MICROBIOLOGY; ANTIBIOTIC-RESISTANCE; BACILLUS-ANTHRACIS; BIOTHREAT AGENTS; HIGH-THROUGHPUT; AMPLIFICATION; DNA AB Antibiotic resistance (AR) is an epidemic of increasing magnitude requiring rapid identification and profiling for appropriate and timely therapeutic measures and containment strategies. In this context, ciprofloxacin is part of the first-line of countermeasures against numerous high consequence bacteria. Significant resistance can occur via single nucleotide polymorphisms (SNP) and deletions within ciprofloxacin targeted genes. Ideally, use of ciprofloxacin would be prefaced with AR determination to avoid overuse or misuse of the antibiotic. Here, we describe the development and evaluation of a panel of 44 single-stranded molecular inversion probes (MIPs) coupled to next-generation sequencing (NGS) for the detection of genetic variants known to confer ciprofloxacin resistance in Bacillus anthracis, Yersinia pestis, and Francisella tularensis. Sequencing results demonstrate MIPs capture and amplify targeted regions of interest at significant levels of coverage. Depending on the genetic variant, limits of detection (LOD) for high-throughput pooled sequencing ranged from approximately 300-1800 input genome copies. LODs increased 10-fold in the presence of contaminating human genome DNA. In addition, we show that MIPs can be used as an enrichment step with high resolution melt (HRM) real-time PCR which is a sensitive assay with a rapid time-to-answer. Overall, this technology is a multiplexable upfront enrichment applicable with multiple downstream molecular assays for the detection of targeted genetic regions. C1 [Stefan, Christopher P.; Koehler, Jeffrey W.; Minogue, Timothy D.] US Army, Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. RP Minogue, TD (reprint author), US Army, Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. EM timothy.d.minogue.civ@mail.mil OI Koehler, Jeffrey/0000-0003-3225-6599 FU Defense Threat Reduction Agency (DTRA) FX This work was supported by the Defense Threat Reduction Agency (DTRA). The opinions, interpretations, conclusions, and recommendations contained herein are those of the authors and are not necessarily endorsed by the US Army. NR 45 TC 1 Z9 1 U1 4 U2 10 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD MAY 13 PY 2016 VL 6 AR 25904 DI 10.1038/srep25904 PG 12 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DL6SP UT WOS:000375769700001 PM 27174456 ER PT J AU Newburgh, GA Dubinskii, M AF Newburgh, G. A. Dubinskii, M. TI High power eye-safe Er3+:YVO4 laser diode-pumped at 976 nm SO ELECTRONICS LETTERS LA English DT Article DE erbium; yttrium compounds; semiconductor lasers; optical pumping; diffraction gratings; slabs; laser cavity resonators; light polarisation; YVO4:Er3+; size 10 mm; wavelength 970 nm to 980 nm; wavelength 1603 nm; quasicontinuous wave regime; -polarisation; sigma-polarisation; laser cavity axis; c-axis; slab; near diffraction limited beam quality; single crystal; laser diode-pumping; high power eye-safe laser ID 1.6 MU-M; CRYSTALS; RANGE AB The performance of an eye-safe laser based on a Er-doped orthovanadate (Er:YVO4) single crystal, diode-pumped at 976 nm (I-4(15/2) I-4(11/2) transition) and operating at 1603 nm (I-4(13/2) I-4(15/2) transition) with near diffraction limited beam quality is reported. A 10 mm long Er3+:YVO4 slab, cut with its c-axis perpendicular to the laser cavity axis, was pumped in sigma-polarisation and lased in -polarisation. The laser operated in a quasi-continuous wave regime with nearly 9 W output power, and with a slope efficiency of about 39% with respect to absorbed power. This is believed to be the highest efficiency and highest power achieved from an Er3+:YVO4 laser pumped in the 970-980 nm absorption band. C1 [Newburgh, G. A.; Dubinskii, M.] US Army, Res Lab, Adelphi Lab Ctr, Sensors & Elect Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RP Newburgh, GA (reprint author), US Army, Res Lab, Adelphi Lab Ctr, Sensors & Elect Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM george.a.newburgh.civ@mail.mil NR 13 TC 0 Z9 0 U1 12 U2 13 PU INST ENGINEERING TECHNOLOGY-IET PI HERTFORD PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD SG1 2AY, ENGLAND SN 0013-5194 EI 1350-911X J9 ELECTRON LETT JI Electron. Lett. PD MAY 12 PY 2016 VL 52 IS 10 DI 10.1049/el.2016.0252 PG 2 WC Engineering, Electrical & Electronic SC Engineering GA DM1VW UT WOS:000376136000043 ER PT J AU Ayangeakaa, AD Garg, U Petrache, CM Guo, S Zhao, PW Matta, JT Nayak, BK Patel, D Janssens, RVF Carpenter, MP Chiara, CJ Kondev, FG Lauritsen, T Seweryniak, D Zhu, S Ghugre, SS Palit, R AF Ayangeakaa, A. D. Garg, U. Petrache, C. M. Guo, S. Zhao, P. W. Matta, J. T. Nayak, B. K. Patel, D. Janssens, R. V. F. Carpenter, M. P. Chiara, C. J. Kondev, F. G. Lauritsen, T. Seweryniak, D. Zhu, S. Ghugre, S. S. Palit, R. TI In-beam spectroscopy of medium- and high-spin states in Ce-133 SO PHYSICAL REVIEW C LA English DT Article ID COINCIDENCE DATA SETS; ROTATIONAL BANDS; LIFETIME MEASUREMENTS; MAGNETIC ROTATION; COLLECTIVITY AB Medium and high-spin states in Ce-133 were investigated using the Cd-116(Ne-22, 5n) reaction and the Gammasphere array. The level scheme was extended up to an excitation energy of similar to 22.8 MeV and spin 93/2 (h) over bar. Eleven bands of quadrupole transitions and two new dipole bands are identified. The connections to low-lying states of the previously known, high-spin triaxial bands were firmly established, thus fixing the excitation energy and, in many cases, the spin parity of the levels. Based on comparisons with cranked Nilsson-Strutinsky calculations and tilted axis cranking covariant density functional theory, it is shown that all observed bands are characterized by pronounced triaxiality. Competing multiquasiparticle configurations are found to contribute to a rich variety of collective phenomena in this nucleus. C1 [Ayangeakaa, A. D.; Garg, U.; Matta, J. T.; Nayak, B. K.; Patel, D.] Univ Notre Dame, Dept Phys, Notre Dame, IN 46556 USA. [Petrache, C. M.; Guo, S.] Univ Paris Saclay, CNRS, IN2P3, Ctr Sci Nucl & Sci Mat, Bat 104-108, F-91405 Orsay, France. [Ayangeakaa, A. D.; Zhao, P. W.; Janssens, R. V. F.; Carpenter, M. P.; Chiara, C. J.; Lauritsen, T.; Seweryniak, D.; Zhu, S.] Argonne Natl Lab, Div Phys, Argonne, IL 60439 USA. [Chiara, C. J.] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA. [Kondev, F. G.] Argonne Natl Lab, Nucl Engn Div, 9700 S Cass Ave, Argonne, IL 60439 USA. [Ghugre, S. S.] UGC DAE Consortium Sci Res, Kolkata 700098, India. [Palit, R.] Tata Inst Fundamental Res, Homi Bhabha Rd, Bombay 400005, Maharashtra, India. [Palit, R.] Univ Notre Dame, Joint Inst Nucl Astrophys, Notre Dame, IN 46556 USA. [Matta, J. T.] Oak Ridge Natl Lab, Div Phys, Oak Ridge, TN 37830 USA. [Nayak, B. K.] Bhabha Atom Res Ctr, Div Nucl Phys, Bombay 400085, Maharashtra, India. [Patel, D.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. [Chiara, C. J.] US Army Res Lab, Adelphi, MD 20783 USA. RP Ayangeakaa, AD (reprint author), Univ Notre Dame, Dept Phys, Notre Dame, IN 46556 USA.; Ayangeakaa, AD (reprint author), Argonne Natl Lab, Div Phys, Argonne, IL 60439 USA. RI Zhao, Pengwei/F-9107-2010; Palit, Rudrajyoti/F-5185-2012 OI Zhao, Pengwei/0000-0001-8243-2381; FU U.S. National Science Foundation [PHY07-58100, PHY-0822648, PHY-1068192, PHY-1419765]; U.S. Department of Energy, Office of Nuclear Physics [DE-FG02-94ER40834, DE-AC02-06CH11357] FX C.M.P. expresses his gratitude to Prof. I. Ragnarsson for providing the CNS codes, for the training on how to use them, and for enlightening comments on the theoretical interpretation of the results. This work was supported in part by the U.S. National Science Foundation Grants No. PHY07-58100, No. PHY-0822648, No. PHY-1068192, and No. PHY-1419765, and the U.S. Department of Energy, Office of Nuclear Physics, under Grant No. DE-FG02-94ER40834 (UM) and Contract No. DE-AC02-06CH11357 (ANL). This research used resources of ANL's ATLAS facility, which is a DOE Office of Science User Facility. NR 30 TC 2 Z9 2 U1 2 U2 3 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2469-9985 EI 2469-9993 J9 PHYS REV C JI Phys. Rev. C PD MAY 12 PY 2016 VL 93 IS 5 AR 054317 DI 10.1103/PhysRevC.93.054317 PG 19 WC Physics, Nuclear SC Physics GA DL9YN UT WOS:000375999500002 ER PT J AU Tenan, MS AF Tenan, Matthew S. TI A Statistical Method and Tool to Account for Indirect Calorimetry Differential Measurement Error in a Single-Subject Analysis SO FRONTIERS IN PHYSIOLOGY LA English DT Article DE exercise testing; VO2; indirect calorimetry; research methods; cost of transport ID VARIABILITY; INFERENCE; SYSTEMS AB Indirect calorimetry and oxygen consumption (VO2) are accepted tools in human physiology research. It has been shown that indirect calorimetry systems exhibit differential measurement error, where the error of a device is systematically different depending on the volume of gas flow. Moreover, systems commonly report multiple decimal places of precision, giving the clinician a false sense of device accuracy. The purpose of this manuscript is to demonstrate the use of a novel statistical tool which models the reliability of two specific indirect calorimetry systems, Douglas bag and Parvomedics 2400 TrueOne, as univariate normal distributions and implements the distribution overlapping coefficient to determine the likelihood that two VO2 measures are the same. A command line implementation of the tool is available for the R programming language as well as a web-based graphical user interface (GUI). This tool is valuable for clinicians performing a single-subject analysis as well as researchers interested in determining if their observed differences exceed the error of the device. C1 [Tenan, Matthew S.] US Army Res Lab, Human Res & Engn Directorate, Integrated Capabil Enhancement Branch, Aberdeen, MD USA. RP Tenan, MS (reprint author), US Army Res Lab, Human Res & Engn Directorate, Integrated Capabil Enhancement Branch, Aberdeen, MD USA. EM matthew.s.tenan.civ@mail.mil NR 19 TC 0 Z9 0 U1 2 U2 2 PU FRONTIERS MEDIA SA PI LAUSANNE PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLAND SN 1664-042X J9 FRONT PHYSIOL JI Front. Physiol. PD MAY 11 PY 2016 VL 7 AR 172 DI 10.3389/fphys.2016.00172 PG 6 WC Physiology SC Physiology GA DL3SH UT WOS:000375553100001 PM 27242546 ER PT J AU Norberg, SA Johnsen, E Kushner, MJ AF Norberg, Seth A. Johnsen, Eric Kushner, Mark J. TI Helium atmospheric pressure plasma jets interacting with wet cells: delivery of electric fields SO JOURNAL OF PHYSICS D-APPLIED PHYSICS LA English DT Article DE plasma medicine; plasma liquid interactions; atmospheric pressure plasma; plasma jets; electroporation; electric fields and cells; modeling ID DOMAIN DIELECTRIC-SPECTROSCOPY; CANCER-CELLS; PULSES; ELECTROPORATION; TISSUES; DEATH AB The use of atmospheric pressure plasma jets (APPJs) in plasma medicine have produced encouraging results in wound treatment, surface sterilization, deactivation of bacteria, and treatment of cancer cells. It is known that many of the reactive oxygen and nitrogen species produced by the APPJ are critical to these processes. Other key components to treatment include the ion and photon fluxes, and the electric fields produced in cells by the ionization wave of the APPJ striking in the vicinity of the cells. These relationships are often complicated by the cells being covered by a thin liquid layer-wet cells. In this paper, results from a computational investigation of the interaction of APPJs with tissue beneath a liquid layer are discussed. The emphasis of this study is the delivery of electric fields by an APPJ sustained in He/O-2 = 99.8/0.2 flowing into humid air to cells lying beneath water with thickness of 200 mu m. The water layer represents the biological fluid typically covering tissue during treatment. Three voltages were analyzed-two that produce a plasma effluent that touches the surface of the water layer and one that does not touch. The effect of the liquid layer thickness, 50 mu m to 1 mm, was also examined. Comparisons were made of the predicted intracellular electric fields to those thresholds used in the field of bioelectronics. C1 [Norberg, Seth A.; Johnsen, Eric] Univ Michigan, Dept Mech Engn, 2350 Hayward St, Ann Arbor, MI 48109 USA. [Kushner, Mark J.] Univ Michigan, Dept Elect Engn & Comp Sci, 1301 Beal Ave, Ann Arbor, MI 48109 USA. [Norberg, Seth A.] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. RP Kushner, MJ (reprint author), Univ Michigan, Dept Elect Engn & Comp Sci, 1301 Beal Ave, Ann Arbor, MI 48109 USA. EM norbergs@umich.edu; ejohnsen@umich.edu; mjkush@umich.edu FU Department of Energy Office of Fusion Energy Science [DE-SC0001319]; National Science Foundation [CHE-1124724] FX This work was supported by the Department of Energy Office of Fusion Energy Science (DE-SC0001319) and the National Science Foundation (CHE-1124724). NR 46 TC 1 Z9 1 U1 7 U2 23 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0022-3727 EI 1361-6463 J9 J PHYS D APPL PHYS JI J. Phys. D-Appl. Phys. PD MAY 11 PY 2016 VL 49 IS 18 AR 185201 DI 10.1088/0022-3727/49/18/185201 PG 16 WC Physics, Applied SC Physics GA DK9MU UT WOS:000375255300015 ER PT J AU Veysset, D Hsieh, AJ Kooi, S Maznev, AA Masser, KA Nelson, KA AF Veysset, David Hsieh, Alex J. Kooi, Steven Maznev, Alexei A. Masser, Kevin A. Nelson, Keith A. TI Dynamics of supersonic microparticle impact on elastomers revealed by real-time multi-frame imaging SO SCIENTIFIC REPORTS LA English DT Article ID POLY(URETHANE UREA) ELASTOMERS; STRESS-STRAIN BEHAVIOR; SOLID PARTICLE IMPACT; MECHANICAL-PROPERTIES; UNFILLED ELASTOMERS; MOLECULAR-DYNAMICS; RATE DEFORMATION; EROSION; POLYURETHANE; MICROSTRUCTURE AB Understanding high-velocity microparticle impact is essential for many fields, from space exploration to medicine and biology. Investigations of microscale impact have hitherto been limited to postmortem analysis of impacted specimens, which does not provide direct information on the impact dynamics. Here we report real-time multi-frame imaging studies of the impact of 7 mu m diameter glass spheres traveling at 700-900 m/s on elastomer polymers. With a poly(urethane urea) (PUU) sample, we observe a hyperelastic impact phenomenon not seen on the macroscale: a microsphere undergoes a full conformal penetration into the specimen followed by a rebound which leaves the specimen unscathed. The results challenge the established interpretation of the behaviour of elastomers under high-velocity impact. C1 [Veysset, David; Hsieh, Alex J.; Kooi, Steven; Maznev, Alexei A.; Nelson, Keith A.] MIT, Inst Soldier Nanotechnol, 77 Massachusetts Ave, Cambridge, MA 02139 USA. [Veysset, David; Maznev, Alexei A.; Nelson, Keith A.] MIT, Dept Chem, Cambridge, MA 02139 USA. [Hsieh, Alex J.; Masser, Kevin A.] US Army, Res Lab, RDRL WMM G, Aberdeen Proving Ground, MD 21005 USA. RP Veysset, D (reprint author), MIT, Inst Soldier Nanotechnol, 77 Massachusetts Ave, Cambridge, MA 02139 USA.; Veysset, D (reprint author), MIT, Dept Chem, Cambridge, MA 02139 USA. EM dveysset@mit.edu RI Veysset, David/Q-5566-2016 OI Veysset, David/0000-0003-4473-1983 FU U.S. Army through the Institute for Soldier Nanotechnologies; U.S. Army Research Office [W911NF-13-D-0001]; Office of Naval Research DURIP Grant [N00014-13-1-0676] FX This work was supported by the U.S. Army through the Institute for Soldier Nanotechnologies. Funding was provided by the U.S. Army Research Office, under Grant W911NF-13-D-0001. Support was also provided through Office of Naval Research DURIP Grant No. N00014-13-1-0676. NR 36 TC 0 Z9 0 U1 2 U2 7 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD MAY 9 PY 2016 VL 6 AR 25577 DI 10.1038/srep25577 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DL2AP UT WOS:000375435100001 PM 27156501 ER PT J AU Wang, YS Hocut, CM Hoch, SW Creegan, E Fernando, HJS Whiteman, CD Felton, M Huynh, G AF Wang, Yansen Hocut, Christopher M. Hoch, Sebastian W. Creegan, Edward Fernando, Harindra J. S. Whiteman, C. David Felton, Melvin Huynh, Giap TI Triple Doppler wind lidar observations during the mountain terrain atmospheric modeling and observations field campaign SO JOURNAL OF APPLIED REMOTE SENSING LA English DT Article DE triple Doppler wind lidar observation; atmospheric turbulence measurement; atmospheric boundary layer; Doppler lidar and sonic anemometer comparison ID BOUNDARY-LAYER; SONIC ANEMOMETER; COMPLEX TERRAIN; SINGLE-DOPPLER; TURBULENCE; DISPERSION; RETRIEVAL; CASES-99; ENERGY AB Coordinated triple Doppler wind lidars (DWLs) were employed during the Mountain Terrain Atmospheric Modeling and Observations (MATERHORN) program field campaign to observe turbulent winds in the mountain terrain atmospheric boundary layer (ABL). The feasibility of observing large turbulent eddies was investigated by pointing three DWL at an intersecting probe volume adjoining a sonic anemometer mounted on the top of a meteorological tower. The time series and spectra of the sonic anemometer measurement were compared with the lidars. The lidar radial velocities closely followed those of the sonic anemometer, both in time and in the low frequency spectral domain, suggesting that the DWL technique is suitable for observing large turbulent eddies in the ABL. In addition, coordinated scanning triple DWL were used to directly measure the three-dimensional wind vectors, thus circumventing the assumptions required in using single or dual lidar deployments for full velocity measurements. The scanning triple lidar results were in satisfactory agreement with data from tower-based sonic anemometers. Notwithstanding, because of the difficulty of obtaining temporal and spatial synchronizations of the three lidars, the data were scant since a large amount of data had to be rejected in postprocessing. This difficulty is surmountable in the future by employing a robust control system for coordinated scanning. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. C1 [Wang, Yansen; Felton, Melvin; Huynh, Giap] US Army, Res Lab, Adelphi, MD 20783 USA. [Hocut, Christopher M.; Creegan, Edward] US Army, Res Lab, White Sands Missile Range, NM 88002 USA. [Hocut, Christopher M.; Fernando, Harindra J. S.] Univ Notre Dame, Dept Civil & Environm Engn & Earth Sci, Notre Dame, IN 46556 USA. [Hoch, Sebastian W.; Whiteman, C. David] Univ Utah, Dept Atmospher Sci, Salt Lake City, UT 84112 USA. RP Wang, YS (reprint author), US Army, Res Lab, Adelphi, MD 20783 USA. EM yansen.wang.civ@mail.mil FU Office of Naval Research Award [N00014-11-1-0709]; mountain terrain atmospheric modeling and observations (MATERHORN) program; Air Force Weather Agency FX This overall research program was funded by Office of Naval Research Award Grant No. N00014-11-1-0709 and mountain terrain atmospheric modeling and observations (MATERHORN) program. The ARL part of this research was in part supported by the Air Force Weather Agency as an addendum to DOD MATERHORN funding. We thank colleagues from Dugway Proving Ground, University of Norte Dame, and University of Utah for their help and support during the field campaigns. NR 40 TC 1 Z9 1 U1 1 U2 3 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 1931-3195 J9 J APPL REMOTE SENS JI J. Appl. Remote Sens. PD MAY 5 PY 2016 VL 10 AR 026015 DI 10.1117/1.JRS.10.026015 PG 14 WC Environmental Sciences; Remote Sensing; Imaging Science & Photographic Technology SC Environmental Sciences & Ecology; Remote Sensing; Imaging Science & Photographic Technology GA DL5FV UT WOS:000375663600001 ER PT J AU Borstad, GM Batyrev, IG Ciezak-Jenkins, JA AF Borstad, Gustav M. Batyrev, Iskander G. Ciezak-Jenkins, Jennifer A. TI Cyanoacetohydrazide under Pressure: Chemical Changes in a Hydrogen-Bonded Material SO JOURNAL OF PHYSICAL CHEMISTRY A LA English DT Article ID ENERGETIC MATERIAL; RAMAN-SCATTERING; POLAR MOLECULE; NITROGEN; CARBOHYDRAZIDE; ACETONITRILE; CRYSTALS; TRANSFORMATION; DIFFRACTION; TRANSITION AB Cyanoacetohydrazide (CAH, C3H5N3O) has been studied under pressure using diamond anvil cell techniques. CAH was characterized using Raman spectroscopy to 30 GPa and synchrotron X-ray diffraction to 45 GPa. The Raman spectra of CAH show reasonable qualitative agreement with first-principle calculations. The X-ray data reveal that CAH maintains its monoclinic structure to approximately 22 GPa with a density change of 12% over this range. Near 22 GPa, the Raman modes and most of the X-ray diffraction peaks disappear. These pressure-induced changes are irreversible upon the release of pressure, and the transformed sample can be recovered to ambient pressure. The recovered sample is photosensitive and shows reaction even at low laser powers of 10 mW at 532 nm. The paper concludes with observations of the roles of hydrogen bonding, molecular configurations, and the behavior of the cyano group in the pressure-induced changes in CAH. C1 [Borstad, Gustav M.; Batyrev, Iskander G.; Ciezak-Jenkins, Jennifer A.] US Army Res Lab, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA. RP Ciezak-Jenkins, JA (reprint author), US Army Res Lab, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA. EM Jennifer.a.ciezak-jenkins.civ@mail.mil FU Office of Science, Office of Basic Energy Sciences of the U.S. Department of Energy [DE-AC02-05CH11231] FX During this project, coauthor G.M.B. was supported in part by an appointment to the Postdoctoral Research Program at the US Army Research Laboratory administered by the Oak Ridge Associated Universities. Portions of this work were performed at the Advanced Light Source, which is supported by the Director, Office of Science, Office of Basic Energy Sciences, of the U.S. Department of Energy under Contract No. DE-AC02-05CH11231. Finally, we also acknowledge the insightful contributions of two anonymous reviewers. NR 43 TC 0 Z9 0 U1 7 U2 13 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1089-5639 J9 J PHYS CHEM A JI J. Phys. Chem. A PD MAY 5 PY 2016 VL 120 IS 17 BP 2712 EP 2719 DI 10.1021/acqs.jpca.5b11954 PG 8 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA DL4TX UT WOS:000375631500012 PM 27104289 ER PT J AU Sirk, TW Karim, M Lenhart, JL Andzelm, JW Khare, R AF Sirk, Timothy W. Karim, Mir Lenhart, Joseph L. Andzelm, Jan W. Khare, Rajesh TI Bi-modal polymer networks: Viscoelasticity and mechanics from molecular dynamics simulation SO POLYMER LA English DT Article DE Molecular dynamics; Mixed network; Viscoelasticity; Epoxy; High strain-rate ID CROSS-LINKED EPOXY; EFFICIENT GENERATION; AM1-BCC MODEL; FORCE-FIELD; DEFORMATION AB The high strain-rate rheological and mechanical properties of bi-modal epoxy polymer networks were characterized using molecular dynamics simulation. The complex Young's modulus was found by applying a cyclic sinusoidal strain over a wide range of temperatures spanning the glass transition. The non-linear stress response was studied in the glass transition region using uni-axial deformation. We discuss special considerations in computing viscoelastic properties at the high strain-rates available to molecular dynamics. As in experimental studies, the complex modulus is shown to be a function of the network composition and strain rate. However, the high strain-rate simulations performed here predict the existence of broad peaks in the temperature-dependent loss modulus and slow relaxation of the storage modulus. In general, it is observed that network compositions with larger amounts of short, stiff 4,4'-methylenebis(cyclohexylamine) (MCA) cross-linkers lead to an increase in the mechanical glass transition temperature as well as the breadth of the glass transition compared to longer, more flexible poly(oxypropylene) diamine (POP) cross-linkers. When the networks of any composition were deformed beyond the linear region, the stress response displayed a plateau that was associated with the extension of network chains. Published by Elsevier Ltd. C1 [Sirk, Timothy W.; Lenhart, Joseph L.; Andzelm, Jan W.] US Army Res Lab, Macromol Sci & Technol Branch, Aberdeen Proving Ground, MD USA. [Karim, Mir; Khare, Rajesh] Texas Tech Univ, Dept Chem Engn, Box 43121, Lubbock, TX 79409 USA. RP Sirk, TW (reprint author), US Army Res Lab, Macromol Sci & Technol Branch, Aberdeen Proving Ground, MD USA.; Khare, R (reprint author), Texas Tech Univ, Dept Chem Engn, Box 43121, Lubbock, TX 79409 USA. EM tim.sirk@us.army.mil; rajesh.khare@ttu.edu RI Khare, Rajesh/J-2079-2014 OI Khare, Rajesh/0000-0002-8859-766X FU U.S. Army/Battelle Memorial Institute [US0010000287704] FX The work of MK and RK was supported by U.S. Army/Battelle Memorial Institute contract number US0010000287704. NR 29 TC 4 Z9 4 U1 8 U2 31 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0032-3861 EI 1873-2291 J9 POLYMER JI Polymer PD MAY 4 PY 2016 VL 90 BP 178 EP 186 DI 10.1016/j.polymer.2016.03.024 PG 9 WC Polymer Science SC Polymer Science GA DI2CR UT WOS:000373303800019 ER PT J AU Yost, EE Stanek, J DeWoskin, RS Burgoon, LD AF Yost, Erin E. Stanek, John DeWoskin, Robert S. Burgoon, Lyle D. TI Overview of Chronic Oral Toxicity Values for Chemicals Present in Hydraulic Fracturing Fluids, Flowback, and Produced Waters SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID NATURAL-GAS OPERATIONS; SHALE; PENNSYLVANIA; IMPACTS AB Concerns have been raised about potential public health effects that may arise if hydraulic fracturing related chemicals were to impact drinking water resources. This study presents an overview of the chronic oral toxicity values-specifically, chronic oral reference values (RfVs) for noncancer effects, and oral slope factors (OSFs) for cancer-that are available for a list of 1173 chemicals that the United States (U.S.) Environmental Protection Agency (EPA) identified as being associated with hydraulic fracturing, including 1076 chemicals used in hydraulic fracturing fluids and 134 chemicals detected in flowback or produced waters from hydraulically fractured wells. The EPA compiled RfVs and OSFs using six governmental and intergovernmental data sources. Ninety (8%) of the 1076 chemicals reported in hydraulic fracturing fluids and 83 (62%) of the 134 chemicals reported in flowback/produced water had a chronic oral RfV or OSF available from one or more of the six sources. Furthermore, of the 36 chemicals reported in hydraulic fracturing fluids in at least 10% of wells nationwide (identified from EPA's analysis of the FracFocus Chemical Disclosure Registry 1.0), 8 chemicals (22%) had an available chronic oral RfV. The lack of chronic oral RfVs and OSFs for the majority of these chemicals highlights the significant knowledge gap that exists to assess the potential human health hazards associated with hydraulic fracturing. C1 [Yost, Erin E.] US EPA, Oak Ridge Inst Sci & Educ ORISE Res Participat, Natl Ctr Environm Assessment, Res Triangle Pk, Res Triangle Pk, NC 27711 USA. [Yost, Erin E.; Stanek, John; DeWoskin, Robert S.; Burgoon, Lyle D.] US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Res Triangle Pk, Res Triangle Pk, NC 27711 USA. [DeWoskin, Robert S.] etioLogic LLC, Durham, NC 27712 USA. [Burgoon, Lyle D.] US Army Engineer Res & Dev Ctr, Environm Lab, Res Triangle Pk, Res Triangle Pk, NC 27711 USA. RP Burgoon, LD (reprint author), US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Res Triangle Pk, Res Triangle Pk, NC 27711 USA. EM Lyle.D.Burgoon@usace.army.mil OI Burgoon, Lyle/0000-0003-4977-5352 NR 37 TC 6 Z9 6 U1 16 U2 40 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD MAY 3 PY 2016 VL 50 IS 9 BP 4788 EP 4797 DI 10.1021/acs.est.5b04645 PG 10 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA DL3GE UT WOS:000375521400023 PM 27050380 ER PT J AU Knorr, DB Tran, NT Gaskell, KJ Orlicki, JA Woicik, JC Jaye, C Fischer, DA Lenhart, JL AF Knorr, Daniel B., Jr. Tran, Ngon T. Gaskell, Karen J. Orlicki, Joshua A. Woicik, Joseph C. Jaye, Cherno Fischer, Daniel A. Lenhart, Joseph L. TI Synthesis and Characterization of Aminopropyltriethoxysilane-Polydopamine Coatings SO LANGMUIR LA English DT Article ID RAY PHOTOELECTRON-SPECTROSCOPY; GAMMA-AMINOPROPYLTRIETHOXYSILANE; MULTIFUNCTIONAL COATINGS; AQUEOUS-SOLUTION; CROSS-LINKING; THIN-FILMS; DOPAMINE; SURFACES; CATECHOL; SILICON AB Polydopamine coatings are of interest due to the fact that they can promote adhesion to a broad range of materials and can enable a variety of applications. However, the polydopamine-substrate interaction is often noncovalent. To broaden the potential applications of polydopamine, we show the incorporation of 3-aminopropyltriethoxysilane (APTES), a traditional coupling agent capable of covalent bonding to a broad range of organic and inorganic surfaces, into polydopamine coatings. High energy X-ray photoelectron spectroscopy (HE-XPS), conventional XPS, near-edge X-ray absorption fine structure (NEXAFS), Fourier transform infrared-attenuated total reflectance (FTIR-ATR), and ellipsometry measurements were used to investigate changes in coating chemistry and thickness, which suggest covalent incorporation of APTES into polydopamine. These coatings can be deposited either in Tris buffer or by using an aqueous APTES solution as a buffer without Tris. APTES dopamine hydrochloride deposition from solutions with molar ratios between 0:1 and 10:1 allowed us to control the coating composition across a broad range. C1 [Knorr, Daniel B., Jr.; Tran, Ngon T.; Orlicki, Joshua A.; Lenhart, Joseph L.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Gaskell, Karen J.] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA. [Woicik, Joseph C.; Jaye, Cherno; Fischer, Daniel A.] Natl Inst Stand & Technol, Mat Measurement Lab, Gaithersburg, MD 20899 USA. RP Knorr, DB; Lenhart, JL (reprint author), US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM daniel.knorr.civ@mail.mil; joseph.l.lenhart.civ@mail.mil FU U.S. Army Research Laboratory FX Funding for this work was provided by the U.S. Army Research Laboratory. NR 69 TC 3 Z9 3 U1 14 U2 44 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0743-7463 J9 LANGMUIR JI Langmuir PD MAY 3 PY 2016 VL 32 IS 17 BP 4370 EP 4381 DI 10.1021/acs.langmuir.6b00531 PG 12 WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA DL3FY UT WOS:000375520800027 PM 27055091 ER PT J AU Nath-Chowdhury, M Sangaralingam, M Bastien, P Ravel, C Pratlong, F Mendez, J Libman, M Ndao, M AF Nath-Chowdhury, Milli Sangaralingam, Mugundhine Bastien, Patrick Ravel, Christophe Pratlong, Francine Mendez, Juan Libman, Michael Ndao, Momar TI Real-time PCR using FRET technology for Old World cutaneous leishmaniasis species differentiation SO PARASITES & VECTORS LA English DT Article DE qPCR; Real-time PCR; Leishmania; Cutaneous; Diagnosis; FRET; Melting curve ID POLYMERASE-CHAIN-REACTION; MELTING-CURVE ANALYSIS; CYSTEINE PROTEINASE-B; MAJOR-LIKE; IDENTIFICATION; ASSAY; DIAGNOSIS; AMPLIFICATION; INFECTION; TRAVELERS AB Background: Recently, there has been a re-emergence of cutaneous leishmaniasis in endemic countries and an increase in imported cases in non-endemic countries by travelers, workers, expatriates, immigrants, and military force personnel. Old World cutaneous leishmaniasis is caused primarily by Leishmania major, L. tropica and L. aethiopica. Despite their low sensitivity, diagnosis traditionally includes microscopic and histopathological examinations, and in vitro cultivation. Several conventional PCR techniques have been developed for species identification, which are time-consuming and labour-intensive. Real-time PCR using SYBR green dye, although provides rapid detection, may generate false positive signals. Therefore, a rapid and easy method such as a FRET-based real-time PCR would improve not only the turn-around time of diagnosing Old World cutaneous Leishmania species but will also increase its specificity and sensitivity. Methods: A FRET-based real-time PCR assay which amplifies the cathepsin L-like cysteine protease B gene encoding a major Leishmania antigen was developed to differentiate L. major, L. tropica, and L. aethiopica in one single step using one set of primers and probes. Assay performance was tested on cutaneous and visceral strains of Leishmania parasite cultures and isolates of other protozoan parasites as well as human biopsy specimen. Results: The assay readily differentiates between the three Old World cutaneous leishmaniasis species based on their melting curve characteristics. A single Tm at 55.2 +/- 0.5 degrees C for L. aethiopica strains was distinguished from a single Tm at 57.4 +/- 0.2 degrees C for L. major strains. A double curve with melting peaks at 66.6 +/- 0.1 degrees C and 48.1 +/- 0.5 degrees C or 55.8 +/- 0.6 degrees C was observed for all L. tropica strains. The assay was further tested on biopsy specimens, which showed 100 % agreement with results obtained from isoenzyme electrophoresis and Sanger sequencing. Conclusion: Currently, there are no published data on real-time PCR using FRET technology to differentiate between Old World cutaneous Leishmania species. In summary, our assay based on specific hybridization addresses the limitations of previous PCR technology and provides a single step, reliable method of species identification and rapid diagnostic applications. C1 [Nath-Chowdhury, Milli; Sangaralingam, Mugundhine; Libman, Michael; Ndao, Momar] McGill Univ, Ctr Hlth, Res Inst, Natl Reference Ctr Parasitol, Montreal, PQ, Canada. [Bastien, Patrick; Ravel, Christophe; Pratlong, Francine] Ctr Hosp Reg Univ Montpellier, Ctr Natl Reference Leishmanioses, Dept Parasitol Mycol, Montpellier, France. [Bastien, Patrick; Ravel, Christophe; Pratlong, Francine] Univ Montpellier I, Fac Med, CNRS, UMR 5290,IRD 224,UM1 & 2,MIVEGEC, Montpellier, France. [Mendez, Juan] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. [Libman, Michael; Ndao, Momar] McGill Univ, JD MacLean Ctr Trop Dis, Montreal, PQ, Canada. RP Ndao, M (reprint author), McGill Univ, Ctr Hlth, Res Inst, Natl Reference Ctr Parasitol, Montreal, PQ, Canada.; Ndao, M (reprint author), McGill Univ, JD MacLean Ctr Trop Dis, Montreal, PQ, Canada. EM momar.ndao@mcgill.ca FU Public Health Agency of Canada/National Microbiology Laboratory [MOA 4500299739]; Foundation of the Montreal General Hospital; Research Institute of the McGill University Health Centre FX The National Reference Centre for Parasitology is supported by Public Health Agency of Canada/National Microbiology Laboratory grant MOA 4500299739, the Foundation of the Montreal General Hospital and the Research Institute of the McGill University Health Centre. NR 52 TC 0 Z9 0 U1 5 U2 7 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1756-3305 J9 PARASITE VECTOR JI Parasites Vectors PD MAY 3 PY 2016 VL 9 AR 255 DI 10.1186/s13071-016-1531-4 PG 11 WC Parasitology SC Parasitology GA DL7QD UT WOS:000375834300001 PM 27141967 ER PT J AU Narayan, S Beck, MW Reguero, BG Losada, IJ van Wesenbeeck, B Pontee, N Sanchirico, JN Ingram, JC Lange, GM Burks-Copes, KA AF Narayan, Siddharth Beck, Michael W. Reguero, Borja G. Losada, Inigo J. van Wesenbeeck, Bregje Pontee, Nigel Sanchirico, James N. Ingram, Jane Carter Lange, Glenn-Marie Burks-Copes, Kelly A. TI The Effectiveness, Costs and Coastal Protection Benefits of Natural and Nature-Based Defences SO PLOS ONE LA English DT Article ID SEA-LEVEL RISE; CLIMATE-CHANGE; MANGROVE FOREST; SALT MARSHES; VEGETATION; REDUCTION; SERVICES; VARIABILITY; ADAPTATION; ECOSYSTEMS AB There is great interest in the restoration and conservation of coastal habitats for protection from flooding and erosion. This is evidenced by the growing number of analyses and reviews of the effectiveness of habitats as natural defences and increasing funding worldwide for nature-based defences-i.e. restoration projects aimed at coastal protection; yet, there is no synthetic information on what kinds of projects are effective and cost effective for this purpose. This paper addresses two issues critical for designing restoration projects for coastal protection: (i) a synthesis of the costs and benefits of projects designed for coastal protection (nature-based defences) and (ii) analyses of the effectiveness of coastal habitats (natural defences) in reducing wave heights and the biophysical parameters that influence this effectiveness. We (i) analyse data from sixty-nine field measurements in coastal habitats globally and examine measures of effectiveness of mangroves, salt-marshes, coral reefs and seagrass/kelp beds for wave height reduction; (ii) synthesise the costs and coastal protection benefits of fifty-two nature-based defence projects and; (iii) estimate the benefits of each restoration project by combining information on restoration costs with data from nearby field measurements. The analyses of field measurements show that coastal habitats have significant potential for reducing wave heights that varies by habitat and site. In general, coral reefs and salt-marshes have the highest overall potential. Habitat effectiveness is influenced by: a) the ratios of wave height-to-water depth and habitat width-to-wavelength in coral reefs; and b) the ratio of vegetation height-to-water depth in salt-marshes. The comparison of costs of nature-based defence projects and engineering structures show that salt-marshes and mangroves can be two to five times cheaper than a submerged breakwater for wave heights up to half a metre and, within their limits, become more cost effective at greater depths. Nature-based defence projects also report benefits ranging from reductions in storm damage to reductions in coastal structure costs. C1 [Narayan, Siddharth] Univ Calif Santa Barbara, NCEAS, Santa Barbara, CA 93106 USA. [Beck, Michael W.] Univ Calif Santa Cruz, Nat Conservancy, Santa Cruz, CA 95064 USA. [Reguero, Borja G.] UC Santa Cruz, Nat Conservancy, Dept Ocean Sci, Santa Cruz, CA USA. [Losada, Inigo J.] Univ Cantabria, ETSI Caminos Canales & Puertos, Inst Hidraul Ambiental, E-39005 Santander, Spain. [van Wesenbeeck, Bregje] Delft Univ Technol, Deltares, Unit Marine & Coastal Syst, Delft, Netherlands. [Pontee, Nigel] Univ Southampton, HILL CH2M, Coastal Planning & Engn, Swindon, Wilts, England. [Sanchirico, James N.] Univ Calif Davis, Dept Environm Sci & Policy, Davis, CA 95616 USA. [Ingram, Jane Carter] Columbia Univ, Wildlife Conservat Soc, New York, NY USA. [Lange, Glenn-Marie] World Bank, Environm & Nat Resources Global Practice, 1818 H St NW, Washington, DC 20433 USA. [Burks-Copes, Kelly A.] US Army, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS USA. RP Narayan, S (reprint author), Univ Calif Santa Barbara, NCEAS, Santa Barbara, CA 93106 USA. EM sid.narayan@gmail.com FU Nature Conservancy; Wildlife Conservation Society; National Center for Ecological Analysis and Synthesis (NCEAS); Lyda Hill Foundation; Pew Fellowship in Marine Conservation; World Bank WAVES program FX This research was primarily supported by the by SNAP: Science for Nature and People, a collaboration of The Nature Conservancy, the Wildlife Conservation Society and the National Center for Ecological Analysis and Synthesis (NCEAS). The assistance and support of Dr. Filippo Ferrario, Laval University, Quebec, is also gratefully acknowledged. We also gratefully acknowledge support from the Lyda Hill Foundation, a Pew Fellowship in Marine Conservation to MWB, and the World Bank WAVES program. NR 64 TC 1 Z9 1 U1 26 U2 51 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAY 2 PY 2016 VL 11 IS 5 AR e0154735 DI 10.1371/journal.pone.0154735 PG 17 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DL5KB UT WOS:000375674800044 PM 27135247 ER PT J AU Tritsch, A Airel, P Schwake, J Gancayco, J AF Tritsch, Adam Airel, Peter Schwake, Jonothan Gancayco, John TI Does Topical Lidocaine Reduce The Amount of Intravenous Conscious Sedation Required To Complete Diagnostic Upper Endoscopy and Shorten Recovery Time? A Double Blinded, Randomized, Placebo Controlled Study SO GASTROINTESTINAL ENDOSCOPY LA English DT Meeting Abstract C1 [Tritsch, Adam; Airel, Peter; Schwake, Jonothan; Gancayco, John] Brooke Army Med Ctr, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0016-5107 EI 1097-6779 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD MAY PY 2016 VL 83 IS 5 SU S MA Mo1004 BP AB422 EP AB423 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA EI5HF UT WOS:000392524200221 ER PT J AU Hack, DC AF Hack, Dallas C. TI Military Medicine: The Future and Beyond SO MILITARY MEDICINE LA English DT Editorial Material C1 [Hack, Dallas C.] US Army, Med Res & Mat Command, Res & Technol Headquarters, 810 Schreider St, Frederick, MD 21702 USA. RP Hack, DC (reprint author), US Army, Med Res & Mat Command, Res & Technol Headquarters, 810 Schreider St, Frederick, MD 21702 USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAY PY 2016 VL 181 IS 5 SU S BP 1 EP 1 DI 10.7205/MILMED-D-15-00519 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA DW5LJ UT WOS:000383686400001 PM 27168544 ER PT J AU Doll, BA AF Doll, Bruce A. TI Pushing Boundaries SO MILITARY MEDICINE LA English DT Editorial Material C1 [Doll, Bruce A.] US Army, Med Res & Mat Command, 810 Schreider St, Frederick, MD 21702 USA. RP Doll, BA (reprint author), US Army, Med Res & Mat Command, 810 Schreider St, Frederick, MD 21702 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAY PY 2016 VL 181 IS 5 SU S BP 2 EP 4 DI 10.7205/MILMED-D-15-00520 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA DW5LJ UT WOS:000383686400002 PM 27168545 ER PT J AU Hatzfeld, JJ Khalili, RA Hendrickson, TL Reilly, PA AF Hatzfeld, Jennifer J. Khalili, Ramin A. Hendrickson, Teresa L. Reilly, Patricia A. TI Publishing Military Medical Research: Appreciating the Process SO MILITARY MEDICINE LA English DT Editorial Material C1 [Hatzfeld, Jennifer J.; Khalili, Ramin A.; Hendrickson, Teresa L.] Combat Casualty Care Res Program, Joint Program Comm 6, 722 Doughten St, Frederick, MD 21702 USA. [Reilly, Patricia A.] US Army, Med Res & Mat Command, Off Principal Assistant Acquisit, 810 Schreider St, Frederick, MD 21702 USA. RP Hatzfeld, JJ (reprint author), Combat Casualty Care Res Program, Joint Program Comm 6, 722 Doughten St, Frederick, MD 21702 USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAY PY 2016 VL 181 IS 5 SU S BP 5 EP 6 DI 10.7205/MILMED-D-15-00517 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA DW5LJ UT WOS:000383686400003 PM 27168546 ER PT J AU Larres, DT Carr, W Gonzales, EG Hawley, JS AF Larres, David T. Carr, Walter Gonzales, Elizandro G. Hawley, Jason S. TI The Natural History of Acute Recovery of Blast-Induced Mild Traumatic Brain Injury: A Case Series During War SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT Military Health System Research Symposium CY AUG 17-21, 2014 CL Fort Lauderdale, FL ID ACUTE CONCUSSION; EXPLOSIVE BLAST; TBI; NEUROTRAUMA; MANAGEMENT; EXPOSURE; UTILITY; MATTER; MODEL AB Traumatic brain injury (TBI) secondary to blast exposure is a common injury in the Global War on Terrorism, but little is known about the acute effects, recovery, pathophysiology, and neuropathology of blast-induced mild TBI (mTBI) in humans in a battlefield environment. Moreover, there is ongoing debate whether blast-induced mTBI is a different injury with a unique pathophysiology compared with mTBI from blunt trauma. In the case series reported here from Craig Joint Theater Hospital at Bagram Airfield, Afghanistan, 15 military service members with acute concussion/mTBI associated with blast exposure were evaluated within the first 24 hours after concussion and on days 2, 3, 5, and 7 with a Graded Symptom Checklist and a balance assessment, the Balance Error Scoring System. These data suggest that the recovery in blast-induced mTBI follows the pattern of recovery in sports-related concussion reported in The National Collegiate Athletic Association Concussion Study. In this retrospective case series, we provide the first description of the natural history of acute recovery in blast-induced mTBI, and we suspect, given our experience treating military service members, that further observations of the natural history of recovery in blast-induced mTBI will continue to mirror the natural history of recovery in sports concussion. C1 [Larres, David T.] Tripler Army Med Ctr, Occupat Therapy Clin, 1 Jarrett White Rd, Honolulu, HI 96859 USA. [Carr, Walter] Walter Reed Army Inst Res, Dept Behav Biol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. [Gonzales, Elizandro G.] Guthrie Army Hlth Clin, Occupat Therapy, 11050 Mt Belvedere Blvd, Ft Drum, NY 13602 USA. [Hawley, Jason S.] Walter Reed Natl Mil Med Ctr, Dept Neurol, 8901 Rockville Pike, Bethesda, MD 20889 USA. RP Larres, DT (reprint author), Tripler Army Med Ctr, Occupat Therapy Clin, 1 Jarrett White Rd, Honolulu, HI 96859 USA. NR 36 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAY PY 2016 VL 181 IS 5 SU S BP 23 EP 27 DI 10.7205/MILMED-D-15-00152 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA DW5LJ UT WOS:000383686400006 PM 27168549 ER PT J AU Carr, W Stone, JR Walilko, T Young, LA Snook, TL Paggi, ME Tsao, JW Jankosky, CJ Parish, RV Ahlers, ST AF Carr, Walter Stone, James R. Walilko, Tim Young, Lee Ann Snook, Tianlu Li Paggi, Michelle E. Tsao, Jack W. Jankosky, Christopher J. Parish, Robert V. Ahlers, Stephen T. TI Repeated Low-Level Blast Exposure: A Descriptive Human Subjects Study SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT Military Health System Research Symposium CY AUG 17-21, 2014 CL Fort Lauderdale, FL ID TRAUMATIC BRAIN-INJURY; NEUROPSYCHOLOGICAL ASSESSMENT METRICS; FUNCTIONAL MRI; MILD; PERFORMANCE; CONCUSSION; SAMPLE AB The relationship between repeated exposure to blast overpressure and neurological function was examined in the context of breacher training at the U.S. Marine Corps Weapons Training Battalion Dynamic Entry School. During this training, Students are taught to apply explosive charges to achieve rapid ingress into secured buildings. For this study, both Students and Instructors participated in neurobehavioral testing, blood toxin screening, vestibular/auditory testing, and neuroimaging. Volunteers wore instrumentation during training to allow correlation of human response measurements and blast overpressure exposure. The key findings of this study were from high-memory demand tasks and were limited to the Instructors. Specific tests showing blast-related mean differences were California Verbal Learning Test II, Automated Neuropsychological Assessment Metrics subtests (Match-to-Sample, Code Substitution Delayed), and Delayed Matching-to-Sample 10-second delay condition. Importantly, apparent deficits were paralleled with functional magnetic resonance imaging using the n-back task. The findings of this study are suggestive, but not conclusive, owing to small sample size and effect. The observed changes yield descriptive evidence for potential neurological alterations in the subset of individuals with occupational history of repetitive blast exposure. This is the first study to integrate subject instrumentation for measurement of individual blast pressure exposure, neurocognitive testing, and neuroimaging. C1 [Carr, Walter] Walter Reed Army Inst Res, Dept Behav Biol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. [Stone, James R.; Snook, Tianlu Li] Univ Virginia Hlth Syst, 480 Ray C Hunt Dr,Room 281,Box 801339, Charlottesville, VA 22903 USA. [Walilko, Tim] Appl Res Associates Inc, 7921 Shaffer Pkwy, Littleton, CO 80127 USA. [Young, Lee Ann] Appl Res Associates Inc, 950 Isom Rd, San Antonio, TX 78216 USA. [Paggi, Michelle E.] Weill Cornell Med Coll, 21 Bloomingdale Rd, White Plains, NY 10605 USA. [Tsao, Jack W.] US Navy, Bur Med & Surg, Traumat Brain Injury Programs, 2300 East St Northwest, Washington, DC 20372 USA. [Jankosky, Christopher J.] Uniformed Serv Univ Hlth Sci, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. [Parish, Robert V.] MEDCOM Irwin Army Community Hosp, 600 Caisson Hill Rd, Ft Riley, KS 66442 USA. [Ahlers, Stephen T.] US Navy, Med Res Ctr, Operat & Undersea Med, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. RP Carr, W (reprint author), Walter Reed Army Inst Res, Dept Behav Biol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. NR 20 TC 1 Z9 1 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAY PY 2016 VL 181 IS 5 SU S BP 28 EP 39 DI 10.7205/MILMED-D-15-00137 PG 12 WC Medicine, General & Internal SC General & Internal Medicine GA DW5LJ UT WOS:000383686400007 PM 27168550 ER PT J AU Martini, WZ Rodriguez, CM Deguzman, R Guerra, JB Martin, AK Pusateri, AE Cap, AP Dubick, MA AF Martini, Wenjun Z. Rodriguez, Cassandra M. Deguzman, Rodolfo Guerra, Jessica B. Martin, Angela K. Pusateri, Anthony E. Cap, Andrew P. Dubick, Michael A. TI Dose Responses of Ibuprofen In Vitro on Platelet Aggregation and Coagulation in Human and Pig Blood Samples SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT Military Health System Research Symposium CY AUG 17-21, 2014 CL Fort Lauderdale, FL ID LACTATED RINGERS; OVERDOSE; PLASMA; HEMORRHAGE; MODEL; RESUSCITATION; INHIBITION; SURVIVAL; EFFICACY; INJURY AB Introduction: Ibuprofen is commonly used by warfighters in the deployed environment. This study investigated its dose effects on in vitro coagulation in human and pig blood. Methods: Blood samples were collected from 6 normal volunteers and 6 healthy pigs and processed to make platelet-adjusted samples (100 x 10(3)/mu L, common transfusion trigger in trauma). Ibuprofen was added to the samples at concentrations of 0 mu g/mL (control), the concentration from the highest recommended oral dose (163 mu g/mL, 1x), and 2x, 4x, 8x, 10x, 12x, 16x, and 20x. Platelet aggregation by Chrono-Log aggregometer and coagulation by rotational thrombelastogram (Rotem) were assessed at 15 minutes after the addition of ibuprofen. Results: A robust inhibition of ibuprofen on arachidonic acid-induced platelet aggregation was observed at all doses tested in human or pig blood. Collagen-stimulated platelet aggregation was inhibited starting at 1x in human blood and 4x in pig blood. Rotem measurements were similarly compromised in pig and human blood starting at 16x, except clot formation time was prolonged at 1x in human blood (all p < 0.05). Conclusion: Ibuprofen inhibited platelet aggregation at recommended doses, and compromised coagulation at higher doses. Human blood was more sensitive to ibuprofen inhibition. Further effort is needed to investigate ibuprofen dose responses on coagulation in vivo. C1 [Martini, Wenjun Z.; Rodriguez, Cassandra M.; Deguzman, Rodolfo; Guerra, Jessica B.; Cap, Andrew P.; Dubick, Michael A.] US Army Inst Surg Res, 3698 Chambers Pass, San Antonio, TX 78234 USA. [Martin, Angela K.] Rice Univ, 6100 Main St, Houston, TX 77005 USA. [Pusateri, Anthony E.] US Army Med Res & Mat Command, 810 Schreider St 100, Frederick, MD 21702 USA. RP Martini, WZ (reprint author), US Army Inst Surg Res, 3698 Chambers Pass, San Antonio, TX 78234 USA. NR 29 TC 0 Z9 0 U1 2 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAY PY 2016 VL 181 IS 5 SU S BP 111 EP 116 DI 10.7205/MILMED-D-15-00381 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA DW5LJ UT WOS:000383686400017 PM 27168560 ER PT J AU Barnard, E Mora, AG Bebarta, VS AF Barnard, Ed Mora, Alejandra G. Bebarta, Vikhyat S. TI Preflight Variables Are Associated With Increased Ventilator Days and 30-Day Mortality in Trauma Casualties Evacuated by Critical Care Air Transport Teams: An Exploratory Retrospective Study SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT Military Health System Research Symposium CY AUG 17-21, 2014 CL Fort Lauderdale, FL ID BRAIN-INJURY; SYSTEM; AFGHANISTAN; OPERATIONS; DEATH; IRAQ AB Background: There are no tools to predict outcomes in the U.S. Air Force Critical Care Air Transport Team (CCATT) trauma patients. The objective of this study was to identify associations between preflight variables and outcomes that could assist planning of ongoing critical care. Methods: This Institutional Review Board approved retrospective study included all patients evacuated from Afghanistan by CCATT between 2007 and 2011. Preflight variables were assessed for associations and examined in logistic regression models. Ventilator time over 72 hours, and 30-day mortality were the primary and secondary outcomes respectively. Results: 1,308 trauma patients (24 years, 98% male) were included; 72% blast. Injury severity score (odds ratio [OR] = 1.04 [1.03-1.06]), preflight packed red blood cell units transfused (OR = 1.05 [1.04-1.07]), and preflight intubated status (OR = 11.9 [8.53-16.89]) were independently associated with increased ventilator days; a composite produced an area under the curve of 0.85 with 86% sensitivity and 56% specificity. Injury severity score (OR = 1.06 [1.03-1.09]), prothrombin time (OR = 2.13 [1.18-4.47]), preflight intubated status (OR = 9.2 [1.88-166.11]), and whole blood (OR = 3.18 [1.38-7.04]) were associated with 30-day mortality; a composite produced an area under the curve of 0.84 with 71% sensitivity and 57% specificity. Conclusion: In our large CCATT study a number of preflight variables were associated with outcomes, which may assist in the future planning of critical care services. C1 [Barnard, Ed; Mora, Alejandra G.; Bebarta, Vikhyat S.] US Army Inst Surg Res, Air Force En Route Care Res Ctr, 59th Med Wing,3698 Chambers Pass Rd,Bldg 3611, San Antonio, TX 78234 USA. [Barnard, Ed] Inst Naval Med, Crescent Rd, Alverstoke P012 2DL, Hants, England. RP Barnard, E (reprint author), US Army Inst Surg Res, Air Force En Route Care Res Ctr, 59th Med Wing,3698 Chambers Pass Rd,Bldg 3611, San Antonio, TX 78234 USA.; Barnard, E (reprint author), Inst Naval Med, Crescent Rd, Alverstoke P012 2DL, Hants, England. RI bebarta, vikhyat/K-3476-2015 NR 28 TC 0 Z9 0 U1 2 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAY PY 2016 VL 181 IS 5 SU S BP 132 EP 137 DI 10.7205/MILMED-D-15-00134 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA DW5LJ UT WOS:000383686400020 PM 27168563 ER PT J AU Mora, AG Ganem, VJ Ervin, AT Maddry, JK Bebarta, VS AF Mora, Alejandra G. Ganem, Victoria J. Ervin, Alicia T. Maddry, Joseph K. Bebarta, Vikhyat S. TI En Route Use of Analgesics in Nonintubated, Critically Ill Patients Transported by US Air Force Critical Care Air Transport Teams SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT Military Health System Research Symposium CY AUG 17-21, 2014 CL Fort Lauderdale, FL ID POSTTRAUMATIC-STRESS-DISORDER; AEROMEDICAL EVACUATION; SERVICE MEMBERS; PAIN; KETAMINE; IRAQ; OPERATIONS; MORPHINE; OUTCOMES; INJURY AB Introduction: U.S. Critical Care Air Transport Teams (CCATTs) evacuate critically ill patients with acute pain in the combat setting. Limited data have been reported on analgesic administration en route, and no study has reported analgesic use by CCATTs. Our objective was to describe analgesics used by CCATTs for nonintubated, critically ill patients during evacuation from a combat setting. Methods: We conducted an institutional review board-approved, retrospective review of CCATT records. We included nonintubated, critically ill patients who were administered analgesics in flight and were evacuated out of theater (2007-2012). Demographics, injury description, analgesics and anesthetics, and predefined clinical adverse events were recorded. Data were presented as mean +/- standard deviation or percentage (%). Results: Of 1,128 records, we analyzed 381 subjects with the following characteristics: age 26 +/- 7.0 years; 98% male; and 97% trauma (70% blast, 17% penetrating, 11% blunt, and 3% burn). The injury severity score was 19 +/- 9. Fifty-one percent received morphine, 39% hydromorphone, 15% fentanyl, and 5% ketamine. Routes of delivery were 63% patient-controlled analgesia (PCA), 32% bolus intravenous (IV) administration, 24% epidural delivery, 21% continuous IV infusions, and 9% oral opioids. Patients that were administered local anesthetics (nerve block or epidural delivery) with IV opioids received a lower total dose of opioids than those who received opioids alone. No differences were associated between analgesics and frequency of complications in flight or postflight. Conclusion: About half of nonintubated, critically ill subjects evacuated out of combat by CCATT received morphine and more than half had a PCA. In our study, ketamine was not frequently used and pain scores were rarely recorded. However, we detected an opioid-sparing effect associated with local anesthetics (regional nerve blocks and epidural delivery). C1 [Mora, Alejandra G.; Ganem, Victoria J.; Ervin, Alicia T.; Maddry, Joseph K.; Bebarta, Vikhyat S.] US Army, Air Force Route Care Res Ctr, Inst Surg Res, 59th MDW,3698 Chambers Pass Rd,Bldg 3611, Ft Sam Houston, TX 78234 USA. [Maddry, Joseph K.; Bebarta, Vikhyat S.] San Antonio Mil Med Ctr, Dept Emergency Med, Brooke Army Med Ctr, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. RP Mora, AG (reprint author), US Army, Air Force Route Care Res Ctr, Inst Surg Res, 59th MDW,3698 Chambers Pass Rd,Bldg 3611, Ft Sam Houston, TX 78234 USA. RI bebarta, vikhyat/K-3476-2015 NR 23 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAY PY 2016 VL 181 IS 5 SU S BP 145 EP 151 DI 10.7205/MILMED-D-15-00194 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA DW5LJ UT WOS:000383686400022 PM 27168565 ER PT J AU Nemeth, C Anders, S Strouse, R Grome, A Crandall, B Pamplin, J Salinas, J Mann-Salinas, E AF Nemeth, Christopher Anders, Shilo Strouse, Robert Grome, Anna Crandall, Beth Pamplin, Jeremy Salinas, Jose Mann-Salinas, Elizabeth TI Developing a Cognitive and Communications Tool for Burn Intensive Care Unit Clinicians SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT Military Health System Research Symposium CY AUG 17-21, 2014 CL Fort Lauderdale, FL AB Background: Burn Intensive Care Unit (BICU) work is necessarily complex and depends on clinician actions, resources, and variable patient responses to interventions. Clinicians use large volumes of data that are condensed in time, but separated across resources, to care for patients. Correctly designed health information technology ( IT) systems may help clinicians to treat these patients more efficiently, accurately, and reliably. We report on a 3-year project to design and develop an ecologically valid IT system for use in a military BICU. Methods: We use a mixed methods Cognitive Systems Engineering approach for research and development. Observations, interviews, artifact analysis, survey, and thematic analysis methods were used to reveal underlying factors that mold the work environment and affect clinician decisions that may affect patient outcomes. Participatory design and prototyping methods have been used to develop solutions. Results: We developed 39 requirements for the IT system and used them to create three use cases to help developers better understand how the system might support clinician work to develop interface prototypes. We also incorporated data mining functions that offer the potential to aid clinicians by recognizing patterns recognition of clinically significant events, such as incipient sepsis. The gaps between information sources and accurate, reliable, and efficient clinical decision that we have identified will enable us to create scenarios to evaluate prototype systems with BICU clinicians, to develop increasingly improved designs, and to measure outcomes. Conclusion: The link from data to analyses, requirements, prototypes, and their evaluation ensures that the solution will reflect and support work in the BICU as it actually occurs, improving staff efficiency and patient care quality. C1 [Nemeth, Christopher; Anders, Shilo; Strouse, Robert; Grome, Anna; Crandall, Beth] Appl Res Associates Inc, Cognit Solut Div, 1750 Commerce Ctr Blvd Dr North, Fairborn, OH 23542 USA. [Pamplin, Jeremy; Salinas, Jose; Mann-Salinas, Elizabeth] US Army Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. RP Nemeth, C (reprint author), Appl Res Associates Inc, Cognit Solut Div, 1750 Commerce Ctr Blvd Dr North, Fairborn, OH 23542 USA. NR 18 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAY PY 2016 VL 181 IS 5 SU S BP 205 EP 213 DI 10.7205/MILMED-D-15-00173 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA DW5LJ UT WOS:000383686400031 PM 27168574 ER PT J AU Drignei, D Mourelatos, Z Kosova, E Hu, J Reed, M Rupp, J Gruber, R Scherer, R AF Drignei, Dorin Mourelatos, Zissimos Kosova, Ervisa Hu, Jingwen Reed, Matthew Rupp, Jonathan Gruber, Rebekah Scherer, Risa TI Uncertainty Assessment in Restraint System Optimization for Occupants of Tactical Vehicles SO SAE INTERNATIONAL JOURNAL OF MATERIALS AND MANUFACTURING LA English DT Article AB We have recently obtained experimental data and used them to develop computational models to quantify occupant impact responses and injury risks for military vehicles during frontal crashes. The number of experimental tests and model runs are however, relatively small due to their high cost. While this is true across the auto industry, it is particularly critical for the Army and other government agencies operating under tight budget constraints. In this study we investigate through statistical simulations how the injury risk varies if a large number of experimental tests were conducted. We show that the injury risk distribution is skewed to the right implying that, although most physical tests result in a small injury risk, there are occasional physical tests for which the injury risk is extremely large. We compute the probabilities of such events and use them to identify optimum design conditions to minimize such probabilities. We also show that the results are robust to various assumptions that the statistical simulations use. C1 [Drignei, Dorin; Mourelatos, Zissimos; Kosova, Ervisa] Oakland Univ, Rochester, MI 48063 USA. [Hu, Jingwen; Reed, Matthew] Univ Michigan, Ann Arbor, MI 48109 USA. [Rupp, Jonathan] Transportat Res Inst, Ann Arbor, MI USA. [Gruber, Rebekah] US Army, TARDEC, Warren, MI USA. [Scherer, Risa] US Army, Washington, DC 20310 USA. RP Drignei, D (reprint author), Oakland Univ, Dept Math & Stat, Rochester, MI 48063 USA.; Mourelatos, Z (reprint author), Oakland Univ, Dept Mech Engn, Rochester, MI 48063 USA. EM drignei@oakland.edu; mourelat@oakland.edu NR 10 TC 0 Z9 0 U1 0 U2 0 PU SAE INT PI WARRENDALE PA 400 COMMONWEALTH DR, WARRENDALE, PA 15096 USA SN 1946-3979 EI 1946-3987 J9 SAE INT J MATER MANU JI SAE Int. J. Mater. Manuf. PD MAY PY 2016 VL 9 IS 2 BP 436 EP 443 DI 10.4271/2016-01-0316 PG 8 WC Transportation Science & Technology SC Transportation GA EA2TS UT WOS:000386448300027 ER PT J AU Petty, AA Hutchings, JK Richter-Menge, JA Tschudi, MA AF Petty, Alek A. Hutchings, Jennifer K. Richter-Menge, Jacqueline A. Tschudi, Mark A. TI Sea ice circulation around the Beaufort Gyre: The changing role of wind forcing and the sea ice state SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article ID ARCTIC-OCEAN; ERA-INTERIM; SNOW DEPTH; MODEL; IMPACT; DRAG; SIMULATIONS; VARIABILITY; CURRENTS; MOTION AB Sea ice drift estimates from feature tracking of satellite passive microwave data are used to investigate seasonal trends and variability in the ice circulation around the Beaufort Gyre, over the multidecadal period 1980-2013. Our results suggest an amplified response of the Beaufort Gyre ice circulation to wind forcing, especially during the late 2000s. We find increasing anticyclonic ice drift across all seasons, with the strongest trend in autumn, associated with increased ice export out of the southern Beaufort Sea (into the Chukchi Sea). A flux gate analysis highlights consistency across a suite of drift products. Despite these seasonal anticyclonic ice drift trends, a significant anticyclonic wind trend occurs in summer only, driven, in-part, by anomalously anticyclonic winds in 2007. Across all seasons, the ice drift curl is more anticyclonic than predicted from a linear relationship to the wind curl in the 2000s, compared to the 1980s/1990s. The strength of this anticyclonic ice drift curl amplification is strongest in autumn and appears to have increased since the 1980s (up to 2010). In spring and summer, the ice drift curl amplification occurs mainly between 2007 and 2010. These results suggest nonlinear ice interaction feedbacks (e.g., a weaker, more mobile sea ice pack), enhanced atmospheric drag, and/or an increased role of the ocean. The results also show a weakening of the anticyclonic wind and ice circulation since 2010. C1 [Petty, Alek A.] Univ Maryland, Earth Syst Sci Interdisciplinary Ctr, College Pk, MD 20742 USA. [Petty, Alek A.] NASA, Goddard Space Flight Ctr, Cryospher Sci Lab, Greenbelt, MD 20771 USA. [Hutchings, Jennifer K.] Oregon State Univ, Coll Earth Ocean & Atmosphere, Corvallis, OR 97331 USA. [Richter-Menge, Jacqueline A.] Cold Reg Res & Engn Lab, Hanover, NH USA. [Tschudi, Mark A.] Univ Colorado, Colorado Ctr Astrodynam Res, Boulder, CO 80309 USA. RP Petty, AA (reprint author), Univ Maryland, Earth Syst Sci Interdisciplinary Ctr, College Pk, MD 20742 USA.; Petty, AA (reprint author), NASA, Goddard Space Flight Ctr, Cryospher Sci Lab, Greenbelt, MD 20771 USA. EM alek.a.petty@nasa.gov FU NASA [NNX13AK36G]; NOAA Ocean Remote Sensing Program FX This work is supported by NASA grant NNX13AK36G and the NOAA Ocean Remote Sensing Program. The NCEP-R2 data were provided by the NOAA/ESRL PSD (http://www.esrl.noaa.gov/psd/data/gridded/data.ncep.reanalysis2.html), the ERA-I data were provided by the ECMWF (http://apps.ecmwf.int/datasets/data/interim_full_daily/), and the JRA-55 data were provided by the NCEP Research Data Archive (RDA) (http://rda.ucar.edu/datasets/ds628.0). The Polar Pathfinder sea ice drift data were provided by the NSIDC (http://nsidc.org/data/nsidc-0116). All CERSAT/IFREMER data sets were obtained from the CERSAT website (ftp://ftp.ifremer.fr/ifremer/cersat/products/gridded/psi-drift/). The passive microwave NASA Team and Bootstrap concentration data were provided by the NSIDC (http://nsidc.org/data/nsidc-0051 and http://nsidc.org/data/nsidc-0079, respectively). The ice draft mooring data were obtained from the Beaufort Gyre Exploration Project website (http://www.whoi.edu/page.do?pid=66559). PIOMAS ice thickness data were obtained from http://psc.apl.uw.edu/research/projects/arctic-sea-ice-volume-anomaly/da ta/. We thank the Editor (Andrey Proshutinsky), three anonymous reviewers, and Miles McPhee for instructive comments that greatly strengthened this manuscript. We would also like to thank the organizers and participants of the 2014 Forum for Arctic Ocean Modeling and Observational Synthesis (FAMOS) workshop for the useful and inspiring discussions regarding this work. We also thank Sinead Farrell for her assistance with earlier versions of this manuscript. All processed datasets used in this study have been archived at http://dx.doi.org/10.5281/zenodo.48464, while the data processing scripts used to create the data/figures are available at https://www.github.com/akpetty/bgdrift2016.git. The primary author may be contacted for any further data requests. NR 74 TC 2 Z9 2 U1 5 U2 5 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-9275 EI 2169-9291 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD MAY PY 2016 VL 121 IS 5 BP 3278 EP 3296 DI 10.1002/2015JC010903 PG 19 WC Oceanography SC Oceanography GA DW2IQ UT WOS:000383466500027 ER PT J AU Mullen, GL Panario, D Thomson, D AF Mullen, G. L. Panario, D. Thomson, D. TI Fast and Simple Modular Interpolation Using Factorial Representation SO AMERICAN MATHEMATICAL MONTHLY LA English DT Article ID POLYNOMIAL FUNCTIONS; Z(M); Z(N) AB We study a representation for polynomial functions over finite rings. This factorial representation is particularly useful for fast interpolation, and we show that it is computationally preferable to the Lagrange Interpolation Formula (LIF) and to Newton interpolation over finite fields and rings. Moreover, over arbitrary finite rings the calculation of the factorial representation aborts naturally when a given mapping does not arise as a polynomial function. C1 [Mullen, G. L.] Penn State Univ, Dept Math, University Pk, PA 16802 USA. [Panario, D.] Carleton Univ, Sch Math & Stat, 1125 Colonel Dr, Ottawa, ON K1S 5B6, Canada. [Thomson, D.] US Mil Acad, Army Cyber Inst, 2101 New South Post Rd,Spellman Hall, West Point, NY 10996 USA. RP Mullen, GL (reprint author), Penn State Univ, Dept Math, University Pk, PA 16802 USA. EM mullen@math.psu.edu; daniel@math.carleton.ca; David.Thomson@usma.edu NR 11 TC 0 Z9 0 U1 0 U2 0 PU MATHEMATICAL ASSOC AMER PI WASHINGTON PA 1529 18TH STREET NW, WASHINGTON, DC 20036 USA SN 0002-9890 EI 1930-0972 J9 AM MATH MON JI Am. Math. Mon. PD MAY PY 2016 VL 123 IS 5 BP 471 EP 480 DI 10.4169/amer.math.monthly.123.5.471 PG 10 WC Mathematics SC Mathematics GA DT8PX UT WOS:000381754700006 ER PT J AU Bazzill, JD Cooper, CL Fan, YC Bavari, S Moon, JJ AF Bazzill, Joseph D. Cooper, Christopher L. Fan, Yuchen Bavari, Sina Moon, James J. TI Lipid nanoparticles incorporated with Ebola glycoprotein for induction of humoral immunity against Ebola infection. SO JOURNAL OF IMMUNOLOGY LA English DT Meeting Abstract CT Annual Meeting of the American-Association-of-Immunologists (AAI) CY MAY 13-17, 2016 CL Seattle, WA SP Amer Assoc Immunologists C1 [Bazzill, Joseph D.; Fan, Yuchen; Moon, James J.] Univ Michigan, Ann Arbor, MI 48109 USA. [Cooper, Christopher L.; Bavari, Sina] US Army Med Res Inst Infect Dis, Ft Detrick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 EI 1550-6606 J9 J IMMUNOL JI J. Immunol. PD MAY 1 PY 2016 VL 196 SU 1 PG 2 WC Immunology SC Immunology GA DS0LX UT WOS:000380288302377 ER PT J AU Stonier, SW James, RM Josleyn, NM Bakken, RR Dye, JM AF Stonier, Spencer W. James, Rebekah M. Josleyn, Nicole M. Bakken, Russell R. Dye, John M. TI Immune correlates for VEEV replicon vaccine protection against Ebolavirus SO JOURNAL OF IMMUNOLOGY LA English DT Meeting Abstract CT Annual Meeting of the American-Association-of-Immunologists (AAI) CY MAY 13-17, 2016 CL Seattle, WA SP Amer Assoc Immunologists C1 [Stonier, Spencer W.; James, Rebekah M.; Josleyn, Nicole M.; Bakken, Russell R.; Dye, John M.] US Army Med Res Inst Infect Dis, Ft Detrick, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 EI 1550-6606 J9 J IMMUNOL JI J. Immunol. PD MAY 1 PY 2016 VL 196 SU 1 MA 146.8 PG 2 WC Immunology SC Immunology GA DS0LX UT WOS:000380288301139 ER PT J AU Castellani, JW Zambraski, EJ Sawka, MN Urso, ML AF Castellani, John W. Zambraski, Edward J. Sawka, Michael N. Urso, Maria L. TI Does high muscle temperature accentuate skeletal muscle injury from eccentric exercise? SO PHYSIOLOGICAL REPORTS LA English DT Article DE Cytokines; eccentric exercise; heat-shock proteins; interleukins; maximal voluntary contraction ID HEAT-SHOCK PROTEINS; INFLAMMATORY MEDIATORS; DAMAGE; HUMANS; ACCLIMATION; ADAPTATION; METABOLISM; STRESS; INTERLEUKIN-6; PERFORMANCE AB Hyperthermia is suspected of accentuating skeletal muscle injury from novel exercise, but this has not been well studied. This study examined if high muscle temperatures alters skeletal muscle injury induced by eccentric exercise (ECC). Eight volunteers (age, 22.5 +/- 4.1 year; height, 169.5 +/- 10.8 cm; body mass, 76.2 +/- 12.6 kg), serving as their own control, and who were not heat acclimatized, completed two elbow flexor ECC trials; in one trial the biceps were heated >40 degrees C (HEAT) and in the other trial there was no heating (NON). HEAT was applied with shortwave diathermy (100 W) for 15 min immediately before the first ECC bout and for 2 min in between each bout. Individuals were followed for 10 days after each ECC session, with a 6-week washout period between arms. The maximal voluntary isometric contraction decreased by 41 +/- 17% and 46 +/- 20% in the NON and HEAT trials, respectively. Bicep circumference increased by 0.07 +/- 0.08 mm (4%, P = 0.04) and relaxed range of motion decreased by 11.5 +/- 8.2 degrees (30%, P < 0.001) in both trials. Serum creatine kinase peaked 72-h following ECC (NON: 6289 +/- 10407; HEAT: 5486 +/- 6229 IU L-1, 38-fold increase, P < 0.01) as did serum myoglobin (NON: 362 +/- 483; HEAT: 355 +/- 373 mu g L-1, 13-fold increase, P < 0.03). Plasma HSP 70 was higher (P < 0.02) in HEAT after 120-h of recovery. There were no differences between treatments for plasma HSP27 and interleukins 1 beta, 6, and 10. The results indicate that >40 degrees C muscle temperature does not alter skeletal muscle injury or functional impairments induced by novel ECC. C1 [Castellani, John W.; Zambraski, Edward J.; Sawka, Michael N.; Urso, Maria L.] US Army Res Inst Environm Med, Natick, MA USA. RP Castellani, JW (reprint author), US Army Res Inst Environm Med, Thermal & Mt Med Div, 10 Gen Greene Ave,Bldg 42, Natick, MA 01760 USA. EM john.w.castellani.civ@mail.mil NR 40 TC 1 Z9 1 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2051-817X J9 PHYSIOL REP JI PHYSIOL. REP. PD MAY PY 2016 VL 4 IS 9 AR e12777 DI 10.14814/phy2.12777 PG 11 WC Physiology SC Physiology GA DR9VQ UT WOS:000380244600002 ER PT J AU Jacobs, K Wu, RB Wang, XT Ashhab, S Chen, QM Rabitz, H AF Jacobs, Kurt Wu, Rebing Wang, Xiaoting Ashhab, Sahel Chen, Qi-Ming Rabitz, Herschel TI Fast quantum communication in linear networks SO EPL LA English DT Article ID EVOLUTION AB Here we consider the speed at which quantum information can be transferred between the nodes of a linear network. Because such nodes are linear oscillators, this speed is also important in the cooling and state preparation of mechanical oscillators, as well as in frequency conversion. We show that if there is no restriction on the size of the linear coupling between two oscillators, then there exist control protocols that will swap their respective states with high fidelity within a time much shorter than a single oscillation period. Standard gradient search methods fail to find these fast protocols. We were able to do so by augmenting standard search methods with a path-tracing technique, demonstrating that this technique has remarkable power to solve time-optimal control problems, as well as confirming the highly challenging nature of these problems. As a further demonstration of the power of path tracing, first introduced by Moore Tibbets et al. (Phys. Rev. A, 86 (2012) 062309), we apply it to the generation of entanglement in a linear network. Copyright (C) EPLA, 2016 C1 [Jacobs, Kurt] US Army, Res Lab, Computat & Informat Sci Directorate, Adelphi, MD 20783 USA. [Jacobs, Kurt] Univ Massachusetts, Dept Phys, Boston, MA 02125 USA. [Jacobs, Kurt; Wang, Xiaoting] Louisiana State Univ, Hearne Inst Theoret Phys, Baton Rouge, LA 70803 USA. [Wu, Rebing; Chen, Qi-Ming] Tsinghua Univ, Dept Automat, Beijing 100084, Peoples R China. [Wu, Rebing; Chen, Qi-Ming] Ctr Quantum Informat Sci & Technol TNList, Beijing 100084, Peoples R China. [Ashhab, Sahel] Hamad Bin Khalifa Univ, Qatar Environm & Energy Res Inst, Qatar Fdn, Doha, Qatar. [Rabitz, Herschel] Princeton Univ, Dept Chem, Princeton, NJ 08544 USA. RP Jacobs, K (reprint author), US Army, Res Lab, Computat & Informat Sci Directorate, Adelphi, MD 20783 USA.; Jacobs, K (reprint author), Univ Massachusetts, Dept Phys, Boston, MA 02125 USA.; Jacobs, K (reprint author), Louisiana State Univ, Hearne Inst Theoret Phys, Baton Rouge, LA 70803 USA. RI Wu, Rebing/A-3647-2013 OI Wu, Rebing/0000-0003-3545-8700 FU NSF [PHY-1005571, PHY-1212413, CCF-1350397]; ARO MURI [W911NF-11-1-0268,]; NSFC [60904034, 61374091, 61134008] FX In the early part of this work KJ was partially supported by the NSF Project Nos. PHY-1005571 and PHY-1212413. KJ and HR were partially supported by the ARO MURI grant W911NF-11-1-0268, and RBW by the NSFC Grant Nos. 60904034, 61374091, and 61134008. XW acknowledges support from the NSF Project No. CCF-1350397. NR 34 TC 0 Z9 0 U1 7 U2 7 PU EPL ASSOCIATION, EUROPEAN PHYSICAL SOCIETY PI MULHOUSE PA 6 RUE DES FRERES LUMIERE, MULHOUSE, 68200, FRANCE SN 0295-5075 EI 1286-4854 J9 EPL-EUROPHYS LETT JI EPL PD MAY PY 2016 VL 114 IS 4 AR 40007 DI 10.1209/0295-5075/114/40007 PG 6 WC Physics, Multidisciplinary SC Physics GA DQ9IR UT WOS:000379524100007 ER PT J AU Malvasi, S Gloyeske, B Johnson, M Miller, T AF Malvasi, Steven Gloyeske, Brian Johnson, Matthew Miller, Timothy TI Multi-Ligamentous Knee Injury in Sports Involving Concomitant Anterior Cruciate Ligament and Patellar Tendon Disruption: A Review of Case Reports SO INTERNATIONAL JOURNAL OF ATHLETIC THERAPY & TRAINING LA English DT Review DE patellar tendon; anterior cruciate ligament; repair ID SIMULTANEOUS RUPTURE AB Background: Injury to the anterior cruciate ligament (ACL) is one of the most common orthopedic injuries in the United States, while injury to the patellar tendon (PT) is less common. A combined rupture to the ACL and PT is consequentially uncommon and increases the difficulty of a correct initial diagnosis. The purpose of this paper is to critically appraise the current peer-reviewed literature regarding multi-ligamentous knee injuries (MLKI) in sport. Methods: A systematic review was undertaken to identify all relevant peer-reviewed articles regarding MLKI from March 1980 to January 2015. All articles pertaining to simultaneous rupture of the ACL and PT were included for review. Results: A total of 27 cases presented in 15 articles were used. Findings suggest that the combination of a palpable gap over the PT, a positive Lachman test, inability to complete terminal knee extension, and a superior position of the patella are clinical examination markers for a possible MLKI involving the ACL and PT. Conclusion: Simultaneous rupture to the ACL and PT is incredibly rare within the sport population, making diagnosis and treatment of such injury challenging. A thorough examination of the extensor mechanism of the knee is important in making the proper diagnosis. C1 [Malvasi, Steven] Keller Army Community Hosp, Dept Orthoped Surg, West Point, NY 10996 USA. [Gloyeske, Brian] St Lukes Univ Hlth Network, Dept Sports Med, Bethlehem, PA USA. [Johnson, Matthew; Miller, Timothy] St Lukes Univ Hlth Network, Dept Phys Therapy, Bethlehem, PA USA. RP Malvasi, S (reprint author), Keller Army Community Hosp, Dept Orthoped Surg, West Point, NY 10996 USA. NR 19 TC 0 Z9 0 U1 1 U2 1 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA SN 2157-7277 EI 2157-7285 J9 INT J ATHL THER TRAI JI Int. J. Athl. Ther. Train. PD MAY PY 2016 VL 21 IS 3 BP 24 EP 27 DI 10.1123/ijatt.2015-0049 PG 4 WC Sport Sciences SC Sport Sciences GA DQ5AC UT WOS:000379215700005 ER PT J AU Drost, RJ Moore, TJ Brodsky, M AF Drost, Robert J. Moore, Terrence J. Brodsky, Michael TI Switching Networks for Pairwise-Entanglement Distribution SO JOURNAL OF OPTICAL COMMUNICATIONS AND NETWORKING LA English DT Article DE Optical fiber networks; Optical switching networks; Quantum entanglement; Quantum networks ID PHOTON-PAIRS; QUANTUM; FIBER AB Quantum networks have the potential to enhance the utility of quantum protocols (for, e.g., cryptography, communication, computation, etc.) by enabling the interoperation of multiple quantum systems. In this paper, we address the distribution of entanglement to the neighbors of a central entanglement source node equipped with a number of sources of entangled photon pairs. A switching network can be an effective component connecting the central node to its neighbors, thus enabling the reconfigurable routing of generated photons. We consider optimal (in terms of insertion loss and the number of component switches) photonic switching networks designed to satisfy the particular requirements of entanglement distribution. We begin by developing a rigorous framework for the study of such entanglement-distribution switching networks. Next, we devise and apply search strategies to design optimal switching networks applicable to entanglement source nodes with 10 or fewer neighbors. Scalable switching networks are then considered for an arbitrarily large number of neighbors, resulting in asymptotically optimal switching fabrics. For all designs, we address efficient routing algorithms for determining a switching-network state that provides the entanglement distribution desired of the switching network at a given time. The combination of optimal switching-network structures and associated efficient routing algorithms addresses a key component of entanglement distribution, thus advancing the state of the art of quantum networks toward practical implementation. C1 [Drost, Robert J.; Moore, Terrence J.; Brodsky, Michael] US Army Res Lab, Adelphi, MD 20783 USA. RP Drost, RJ (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM robert.j.drost6.civ@mail.mil NR 26 TC 1 Z9 1 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1943-0620 EI 1943-0639 J9 J OPT COMMUN NETW JI J. Opt. Commun. Netw. PD MAY PY 2016 VL 8 IS 5 BP 331 EP 342 DI 10.1364/JOCN.8.000331 PG 12 WC Computer Science, Hardware & Architecture; Computer Science, Information Systems; Optics; Telecommunications SC Computer Science; Optics; Telecommunications GA DP5LQ UT WOS:000378539200006 ER PT J AU Wallen, BM Smits, KM Sakaki, T Howington, SE Deepagoda, TKKC AF Wallen, Benjamin M. Smits, Kathleen M. Sakaki, Toshihiro Howington, Stacy E. Deepagoda, Chamindu T. K. K. TI Thermal Conductivity of Binary Sand Mixtures Evaluated through Full Water Content Range SO SOIL SCIENCE SOCIETY OF AMERICA JOURNAL LA English DT Article ID DUAL-POROSITY MODEL; HEAT-PULSE METHOD; REDUCED AIR-PRESSURE; HYDRAULIC CONDUCTIVITY; SEDIMENT MIXTURES; ERROR ANALYSIS; POROUS-MEDIA; WIDE-RANGE; SOIL; TEMPERATURE AB A soil's grain-size distribution affects its physical and hydraulic properties; however, little is known about its effect on soil thermal properties. To better understand how grain-size distribution affects soil thermal properties, specifically the effective thermal conductivity, a set of laboratory experiments was performed using binary mixtures of two uniform sands tightly packed with seven different mixing fractions over the full range of saturation. For each binary mixture, the effective thermal conductivity, lambda, capillary pressure, h(c), and volumetric water content, theta, were measured. Results demonstrated that the lambda-theta relationship exhibited distinct characteristics based on the percentage of fine-and coarse-grained sands. We further compared measured lambda-theta properties with independent estimates from two semi-empirical models (Campbell Model and Lu and Dong Model) to evaluate the models' applicability in relation to physically based parameters associated with changes in soil mixing (e.g., porosity and grain size). Both models were able to fit experimental data but to varying degrees based on the number of physically based parameters used. In general, model improvements are needed to capture the lambda-theta relationship solely on physically based parameters. C1 [Wallen, Benjamin M.; Smits, Kathleen M.; Sakaki, Toshihiro] Colorado Sch Mines, Dept Civil & Environm Engn, Ctr Expt Study Subsurface Environm Proc CESEP, Golden, CO 80401 USA. [Howington, Stacy E.] US Army, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Deepagoda, Chamindu T. K. K.] Univ Peradeniya, Dept Civil Engn, Peradeniya 20400, Sri Lanka. RP Wallen, BM (reprint author), Colorado Sch Mines, Dept Civil & Environm Engn, Ctr Expt Study Subsurface Environm Proc CESEP, Golden, CO 80401 USA. EM benwallen@earthlink.net FU U. S. Army Research Office Award [W911NF-04-1-0169]; Engineering Research and Development Center (ERDC); National Science Foundation [CMMI-1230544, EAR-1447533] FX This research was funded by the U. S. Army Research Office Award W911NF-04-1-0169, the Engineering Research and Development Center (ERDC), and the National Science Foundation (CMMI-1230544 and EAR-1447533). The authors thank John Peters from ERDC for conversations that improved this research and L. Scott Baggett and William J. Massman from the USDA Forest Service whose careful review and comments significantly improved the manuscript. For access to experimental data, the reader is referred to Kathleen Smits (ksmits@mines.edu) at the Colorado School of Mines. NR 76 TC 0 Z9 0 U1 9 U2 10 PU SOIL SCI SOC AMER PI MADISON PA 677 SOUTH SEGOE ROAD, MADISON, WI 53711 USA SN 0361-5995 EI 1435-0661 J9 SOIL SCI SOC AM J JI Soil Sci. Soc. Am. J. PD MAY-JUN PY 2016 VL 80 IS 3 BP 592 EP 603 DI 10.2136/sssaj2015.11.0408 PG 12 WC Soil Science SC Agriculture GA DP9WP UT WOS:000378848900006 ER PT J AU Moore, NLT Altman, DE Gauchan, S Genovese, RF AF Moore, Nicole L. T. Altman, Daniel E. Gauchan, Sangeeta Genovese, Raymond F. TI Adulthood stress responses in rats are variably altered as a factor of adolescent stress exposure SO STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS LA English DT Article DE Adolescence; adulthood; behavior; development; modulation; predator exposure; stress; underwater trauma ID DORSOLATERAL PERIAQUEDUCTAL GRAY; PREDATOR ODOR EXPOSURE; POSTTRAUMATIC-STRESS; CALORIE RESTRICTION; GENE-EXPRESSION; BEHAVIORAL-INHIBITION; DEFENSIVE BEHAVIORS; CHILDHOOD ADVERSITY; LIVE PREDATOR; FEMALE RATS AB Stress exposure during development may influence adulthood stress response severity. The present study investigates persisting effects of two adolescent stressors upon adulthood response to predator exposure (PE). Rats were exposed to underwater trauma (UWT) or PE during adolescence, then to PE after reaching adulthood. Rats were then exposed to predator odor (PO) to test responses to predator cues alone. Behavioral and neuroendocrine assessments were conducted to determine acute effects of each stress experience. Adolescent stress altered behavioral response to adulthood PE. Acoustic startle response was blunted. Bidirectional changes in plus maze exploration were revealed as a factor of adolescent stress type. Neuroendocrine response magnitude did not predict severity of adolescent or adult stress response, suggesting that different adolescent stress events may differentially alter developmental outcomes regardless of acute behavioral or neuroendocrine response. We report that exposure to two different stressors in adolescence may differentially affect stress response outcomes in adulthood. Acute response to an adolescent stressor may not be consistent across all stressors or all dependent measures, and may not predict alterations in developmental outcomes pertaining to adulthood stress exposure. Further studies are needed to characterize factors underlying long-term effects of a developmental stressor. C1 [Moore, Nicole L. T.; Altman, Daniel E.; Gauchan, Sangeeta; Genovese, Raymond F.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Mil Psychiat Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. RP Moore, NLT (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Mil Psychiat Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM nicole.l.moore46.mil@mail.mil FU Military Operational Medicine Research Program, US Army Medical Research and Materiel Command FX This study was supported by the Military Operational Medicine Research Program, US Army Medical Research and Materiel Command. The funding organization had no role in the writing of this article or decision to submit for publication. NR 61 TC 0 Z9 0 U1 3 U2 5 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND SN 1025-3890 EI 1607-8888 J9 STRESS JI Stress PD MAY PY 2016 VL 19 IS 3 BP 295 EP 302 DI 10.1080/10253890.2016.1191465 PG 8 WC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences SC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences & Neurology GA DQ0WI UT WOS:000378922100004 PM 27295201 ER PT J AU Strode, MA Sherman, W Mangieri, CW Bland, CM Sparks, PJ Faler, BJ Prasad, BM Choi, YU AF Strode, Matthew A. Sherman, William Mangieri, Chris W. Bland, Christopher M. Sparks, Preston J. Faler, Byron J. Prasad, Balakrishna M. Choi, Yong U. TI Randomized trial of OFIRMEV versus placebo for pain management after laparoscopic sleeve gastrectomy SO SURGERY FOR OBESITY AND RELATED DISEASES LA English DT Article DE Bariatric; Sleeve; Ofirmev; Pain ID NONSTEROIDAL ANTIINFLAMMATORY DRUGS; POSTOPERATIVE PAIN; INTRAVENOUS PARACETAMOL; DOUBLE-BLIND; SURGERY; ACETAMINOPHEN AB Background: OFIRMEV is an intravenous form of acetaminophen approved by the Food and Drug Administration for use as an antipyretic and treatment of mild to moderate pain alone or in conjunction with opioid medications. Intravenous APAP use in postsurgical pain management has been reported to decrease opioid usage, time to rescue dose, and subjective pain. Objectives: We used a placebo-controlled, randomized double-blind study to test the efficacy of OFIRMEV in decreasing opioid use and subjective pain after laparoscopic sleeve gastrectomy. Setting: U.S. military training hospital. Methods: Thirty-four patients who met criteria were enrolled and randomly assigned to 2 separate limbs of the study. The OFIRMEV and placebo groups had similar mean age ranges (48 11 and 50 +/- 11 yr) and a female/male ratio of 5:1 and 6:1, respectively. The patients received an intraoperative dose and then postoperative administration of intravenous OFIRMEV 1 g or placebo every 6 hours for 24 hours in addition to fentanyl via patient-controlled analgesia. Subjective pain scores, the total amount of fentanyl used, time to rescue of first narcotic dose, and total postanesthesia care unit (PACU) narcotic use were measured during the first 24 hours after surgery. Results: Subjective pain score was significantly decreased compared with baseline at 12, 16, and 20 hours after surgery in OFIRMEV-treated patients but not in the placebo group. However, total narcotic use, time to rescue of first narcotic dose, and total PACU narcotic dose were not statistically different between the 2 groups. Conclusion: Intravenous OFIRMEV use caused a modest but statistically significant decrease in subjective pain without affecting narcotic use after laparoscopic sleeve gastrectomy. (Surg Obes Relat Dis 2015;0:000-00.) (C) 2015 American Society for Metabolic and Bariatric Surgery. All rights reserved. (Surg Obes Relat Dis 2016;12:772-777.) Published by Elsevier Inc. on behalf of American Society for Metabolic and Bariatric Surgery. C1 [Strode, Matthew A.; Sherman, William; Mangieri, Chris W.; Bland, Christopher M.; Sparks, Preston J.; Faler, Byron J.; Choi, Yong U.] Eisenhower Army Med Ctr, Dept Surg, Ft Gordon, GA USA. [Prasad, Balakrishna M.] Eisenhower Army Med Ctr, Dept Clin Invest, Ft Gordon, GA USA. RP Strode, MA (reprint author), 2437 River Birch Dr, Evans, GA 30809 USA. EM Matthewallenstrode@gmail.com NR 16 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1550-7289 EI 1878-7533 J9 SURG OBES RELAT DIS JI Surg. Obes. Relat. Dis. PD MAY PY 2016 VL 12 IS 4 BP 772 EP 777 DI 10.1016/j.soard.2015.08.512 PG 6 WC Surgery SC Surgery GA DP3AO UT WOS:000378365000006 PM 26525369 ER PT J AU Choi, Y AF Choi, Yong TI Comment on: Anastomotic techniques in open Roux-en-Y gastric bypass: primary open surgery and converted procedures SO SURGERY FOR OBESITY AND RELATED DISEASES LA English DT Editorial Material ID GASTROJEJUNAL ANASTOMOSIS C1 [Choi, Yong] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA. RP Choi, Y (reprint author), Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1550-7289 EI 1878-7533 J9 SURG OBES RELAT DIS JI Surg. Obes. Relat. Dis. PD MAY PY 2016 VL 12 IS 4 BP 789 EP 789 PG 1 WC Surgery SC Surgery GA DP3AO UT WOS:000378365000010 PM 26898672 ER PT J AU Hutchinson, D Mathews, J Sullivan, JT Akey, A Aziz, MJ Buonassisi, T Persans, P Warrender, JM AF Hutchinson, David Mathews, Jay Sullivan, Joseph T. Akey, Austin Aziz, Michael J. Buonassisi, Tonio Persans, Peter Warrender, Jeffrey M. TI Effect of layer thickness on device response of silicon heavily supersaturated with sulfur SO AIP ADVANCES LA English DT Article ID ABSORPTION; BAND AB We report on a simple experiment in which the thickness of a hyperdoped silicon layer, supersaturated with sulfur by ion implantation followed by pulsed laser melting and rapid solidification, is systematically varied at constant average sulfur concentration, by varying the implantation energy, dose, and laser fluence. Contacts are deposited and the external quantum efficiency (EQE) is measured for visible wavelengths. We posit that the sulfur layer primarily absorbs light but contributes negligible photocurrent, and we seek to support this by analyzing the EQE data for the different layer thicknesses in two interlocking ways. In the first, we use the measured concentration depth profiles to obtain the approximate layer thicknesses, and, for each wavelength, fit the EQE vs. layer thickness curve to obtain the absorption coefficient of hyperdoped silicon for that wavelength. Comparison to literature values for the hyperdoped silicon absorption coefficients [S.H. Pan et al. Applied Physics Letters 98, 121913 (2011)] shows good agreement. Next, we essentially run this process in reverse; we fit with Beer's law the curves of EQE vs. hyperdoped silicon absorption coefficient for those wavelengths that are primarily absorbed in the hyperdoped silicon layer, and find that the layer thicknesses obtained from the fit are in good agreement with the original values obtained from the depth profiles. We conclude that the data support our interpretation of the hyperdoped silicon layer as providing negligible photocurrent at high S concentrations. This work validates the absorption data of Pan et al. [Applied Physics Letters 98, 121913 (2011)], and is consistent with reports of short mobility-lifetime products in hyperdoped layers. It suggests that for optoelectronic devices containing hyperdoped layers, the most important contribution to the above band gap photoresponse may be due to photons absorbed below the hyperdoped layer. (C) 2016 Author(s). C1 [Hutchinson, David; Persans, Peter] Rensselaer Polytech Inst, Dept Phys Appl Phys & Astron, Troy, NY 12180 USA. [Hutchinson, David] US Mil Acad, Dept Phys & Nucl Engn, West Point, NY 10996 USA. [Mathews, Jay; Warrender, Jeffrey M.] US Army ARDEC, Benet Labs, Watervliet, NY 12189 USA. [Mathews, Jay] Univ Dayton, Dept Phys, Dayton, OH 45469 USA. [Sullivan, Joseph T.; Akey, Austin; Buonassisi, Tonio] MIT, Sch Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA. [Akey, Austin; Aziz, Michael J.] Harvard Univ, John A Paulson Sch Engn & Appl Sci, Cambridge, MA 02138 USA. RP Warrender, JM (reprint author), US Army ARDEC, Benet Labs, Watervliet, NY 12189 USA. EM jwarrend@post.harvard.edu OI Mathews, Jay/0000-0001-5769-5382; Warrender, Jeffrey/0000-0001-6932-8344 FU Army Research Laboratory's Institute for Soldier Nanotechnology FX We gratefully acknowledge Michael Magaletta for data collection, Daniel Recht for technical assistance, and Harry Efstathiadis and Girish Malladi of SUNY Polytechnic Institute(NY) for Rutherford backscattering spectrometry data. This work was partially supported by funding through the Army Research Laboratory's Institute for Soldier Nanotechnology. NR 18 TC 1 Z9 1 U1 6 U2 13 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 2158-3226 J9 AIP ADV JI AIP Adv. PD MAY PY 2016 VL 6 IS 5 AR 055307 DI 10.1063/1.4948986 PG 7 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Science & Technology - Other Topics; Materials Science; Physics GA DO7KX UT WOS:000377962500078 ER PT J AU Mangieri, CW Strode, MA Sherman, WE Pierotti, ML Faler, BJ Choi, YU AF Mangieri, Christopher W. Strode, Matthew A. Sherman, William E. Pierotti, Matthew L. Faler, Byron J. Choi, Yong U. TI Institutional Improvement in Weight Loss after Laparoscopic Sleeve Gastrectomy SO AMERICAN SURGEON LA English DT Article ID Y GASTRIC BYPASS; BARIATRIC SURGERY; LEARNING-CURVE; GUIDELINES; EXPERIENCE; BEHAVIOR; SUCCESS; PATIENT; OBESITY; IMPACT AB Laparoscopic sleeve gastrectomy (LSG) is a recent addition to the bariatric surgery armamentarium. It has been demonstrated to be an efficacious stand-alone bariatric procedure in regard to weight loss. This study evaluates the progress of our initial experience with LSG. Retrospective review of prospective data from 2008 to 2010. Compared data between our first operative year of experience with LSG (2008) and our third year of experience (2010). Data compared for up to three years postoperatively. End points were percentage of excess body weight loss (% EWL) and percentage of excess body mass index loss (% EBL). Institutional improvement in % EWL and % EBL rates as our collective experience increased with LSG. Mean increase in % EWL of 14 per cent and mean increase of % EBL of 22 per cent. In our first year performing LSG the institutional weight loss was < 50 per cent EWL, which is often cited as a benchmark level for "success" after bariatric surgery. By our third year of experience with LSG we achieved an institutional weight loss >50 per cent EWL. Institutional improvement in weight loss results with LSG as the collective experience increased. Several factors could have contributed to this observation to include a surgical mentorship program and the institution of formal nutritional education. This study demonstrates that institutional experience is a significant factor in weight loss results with LSG. C1 [Mangieri, Christopher W.; Strode, Matthew A.; Sherman, William E.; Pierotti, Matthew L.; Faler, Byron J.; Choi, Yong U.] Dwight D Eisenhower Army Med Ctr, Dept Gen Surg, 300 East Hosp Rd, Ft Gordon, GA 30905 USA. RP Mangieri, CW (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Gen Surg, 300 East Hosp Rd, Ft Gordon, GA 30905 USA. EM christopher.w.mangieri.mil@mail.mil NR 34 TC 0 Z9 0 U1 1 U2 1 PU SOUTHEASTERN SURGICAL CONGRESS PI CUMMING PA 115 SAMARITAN DR, #200, CUMMING, GA 30040-2354 USA SN 0003-1348 EI 1555-9823 J9 AM SURGEON JI Am. Surg. PD MAY PY 2016 VL 82 IS 5 BP 448 EP 455 PG 8 WC Surgery SC Surgery GA DO5WS UT WOS:000377854200021 PM 27215727 ER PT J AU Kauvar, DS Osborne, CL AF Kauvar, David S. Osborne, Candice L. TI Discharge Destination after Elective Femoropopliteal Bypass in Patients without Critical Ischemia SO AMERICAN SURGEON LA English DT Article ID PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; PERIOPERATIVE MYOCARDIAL-INFARCTION; CRITICAL LIMB ISCHEMIA; LOWER-EXTREMITY BYPASS; TERM MORTALITY-RATES; INTERMITTENT CLAUDICATION; ARTERIAL-DISEASE; OUTCOME EVENTS; INCREASED RISK; EXERCISE AB Femoropopliteal bypass (FPB) remains a widely accepted treatment option for symptomatic leg ischemia, even in patients without features of critical limb ischemia (CLI). These patients are revascularized to improve symptoms of exertional limb pain and the goal of such treatment is to increase their ability to ambulate within the community. Therefore, the anticipated initial discharge disposition for a patient without CLI undergoing FPB is back to their home. This study examined the disposition at initial discharge of such patients. Data from the 2012 National Surgical Quality Improvement Program registry was queried for all elective FPB performed in patients without CLI. Analysis was limited to patients surviving to initial discharge who were living independently at home before surgery. Initial disposition was defined as to HOME or to a FACILITY (either rehabilitation or skilled nursing); these constituting the study groups. Univariate analysis and multivariable logistic regression were performed to identify patient risk factors for failure to discharge to home. In-hospital and postoperative events were also recorded and compared. Significance was defined at P <= 0.05. In National Surgical Quality Improvement Program 2012, 1060 cases of elective FPB in patients without CLI were found. The mean +/- SD age of the population was 65 +/- 9 years; 359 (34%) of patients were female; 198 (19%) had a reported race other than white; and most (893, 84%) had hypertension. 60 (6%) patients failed to discharge to home (26 to rehabilitation, 34 to skilled nursing). On univariate analysis, age (FACILITY 68 +/- 11 years vs HOME 65 +/- 9 years, P = 0.009), female gender (55% vs 37%, P < 0.001), nonwhite race (30% vs 18%, P = 0.007), and a history of diabetes (48% vs 33%, P = 0.01), dialysis (5% vs 1.3%, P = 0.02) congestive heart failure (5% vs 1.1%, P = 0.01), or a stroke (cerebrovascular accident, 5% vs 2.6%, P = 0.01) were found to predict failure to discharge to home. On multivariate analysis, female gender [odds ratio (OR) = 2.4, 95% confidence interval = 1.4-4.1, P = 0.002], and a history of congestive heart failure (OR 5 4.7, 1.2-18, 0.03] or cerebrovascular accident (OR 5 3.4, 1.9-9.4, 0.02) independently predicted failure to discharge to home. FACILITY patients had higher rates of infectious complications (8.3% vs 1.4%, P < 0.001), myocardial infarction (3.3% vs 0.8%, P = 0.05), operative transfusion (22% vs 5.8%, P < 0.001), and unplanned reoperation (17% vs 2.4%, P < 0.001) during their initial hospitalization. Elective FPB results in a low but not negligible failure of initial return to the community in patients without CLI. Female gender and serious comorbidities predict initial discharge to a facility, which is associated with a complicated hospital course. Careful patient selection is important to achieve good outcomes in this population and furthermore study into the specific preoperative functional and socioeconomic factors predicting failure of early return to the community is warranted. C1 [Kauvar, David S.] Dwight D Eisenhower Army Med Ctr, Vasc Surg Serv, Ft Gordon, GA USA. [Kauvar, David S.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Osborne, Candice L.] Univ Texas Med Branch, Dept Rehabil Sci, Galveston, TX 77555 USA. RP Kauvar, DS (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Surg, 300 Hosp Dr, Ft Gordon, GA 30905 USA. EM davekauvar@gmail.com NR 19 TC 0 Z9 0 U1 0 U2 0 PU SOUTHEASTERN SURGICAL CONGRESS PI CUMMING PA 115 SAMARITAN DR, #200, CUMMING, GA 30040-2354 USA SN 0003-1348 EI 1555-9823 J9 AM SURGEON JI Am. Surg. PD MAY PY 2016 VL 82 IS 5 BP 462 EP 467 PG 6 WC Surgery SC Surgery GA DO5WS UT WOS:000377854200023 PM 27215729 ER PT J AU Hart, CR Reznicek, NJ Wilson, DK Pettit, CL Nykaza, ET AF Hart, Carl R. Reznicek, Nathan J. Wilson, D. Keith Pettit, Chris L. Nykaza, Edward T. TI Comparisons between physics-based, engineering, and statistical learning models for outdoor sound propagation SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID ATMOSPHERIC SURFACE-LAYER; FEEDFORWARD NETWORKS; TRANSMISSION LOSS; HARMONOISE; IMPEDANCE; PREDICTION; GRADIENTS; TUTORIAL; BARRIER AB Many outdoor sound propagation models exist, ranging from highly complex physics-based simulations to simplified engineering calculations, and more recently, highly flexible statistical learning methods. Several engineering and statistical learning models are evaluated by using a particular physics-based model, namely, a Crank-Nicholson parabolic equation (CNPE), as a benchmark. Narrowband transmission loss values predicted with the CNPE, based upon a simulated data set of meteorological, boundary, and source conditions, act as simulated observations. In the simulated data set sound propagation conditions span from downward refracting to upward refracting, for acoustically hard and soft boundaries, and low frequencies. Engineering models used in the comparisons include the ISO 9613-2 method, Harmonoise, and Nord2000 propagation models. Statistical learning methods used in the comparisons include bagged decision tree regression, random forest regression, boosting regression, and artificial neural network models. Computed skill scores are relative to sound propagation in a homogeneous atmosphere over a rigid ground. Overall skill scores for the engineering noise models are 0.6%, -7.1%, and 83.8% for the ISO 9613-2, Harmonoise, and Nord2000 models, respectively. Overall skill scores for the statistical learning models are 99.5%, 99.5%, 99.6%, and 99.6% for bagged decision tree, random forest, boosting, and artificial neural network regression models, respectively. C1 [Hart, Carl R.; Reznicek, Nathan J.; Wilson, D. Keith] US Army Cold Reg Res & Engn Lab, Engn Res & Dev Ctr, Hanover, NH 03755 USA. [Pettit, Chris L.] US Naval Acad, Dept Aerosp Engn, Annapolis, MD 21402 USA. [Nykaza, Edward T.] US Army Construct Engn Res Lab, Engn Res & Dev Ctr, Champaign, IL 61826 USA. RP Hart, CR (reprint author), US Army Cold Reg Res & Engn Lab, Engn Res & Dev Ctr, Hanover, NH 03755 USA. EM carl.r.hart@usace.army.mil RI Wilson, D. Keith/A-4687-2012 OI Wilson, D. Keith/0000-0002-8020-6871 FU U.S. Department of Energy; ERDC-CRREL FX We thank Dirk van Maercke (CSTB) for providing version 2.022 of the Harmonoise point-to-point propagation algorithm. We also thank the anonymous reviewers and associate editor for their valuable feedback. This research was supported in part by an appointment (CRH) to the Student Research Participation Program at the U.S. Army Engineer Research and Development Center-Cold Regions Research and Engineering Laboratory (ERDC-CRREL) administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and ERDC-CRREL. Permission to publish was granted by Director, ERDC-CRREL. NR 51 TC 0 Z9 0 U1 4 U2 5 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 EI 1520-8524 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD MAY PY 2016 VL 139 IS 5 BP 2640 EP 2655 DI 10.1121/1.4948757 PG 16 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA DO3XF UT WOS:000377715100047 PM 27250158 ER PT J AU Zollner, G Sattabongkot, J Vaughan, JA Kankaew, P Robert, LL Thimasarn, K Sithiprasasna, R Coleman, RE AF Zollner, Gabriela Sattabongkot, Jetsumon Vaughan, Jefferson A. Kankaew, Prasan Robert, Leon L. Thimasarn, Krongthong Sithiprasasna, Ratana Coleman, Russell E. TI LONGITUDINAL EVALUATION OF MALARIA EPIDEMIOLOGY IN AN ISOLATED VILLAGE IN WESTERN THAILAND: I. STUDY SITE AND ADULT ANOPHELINE BIONOMICS SO SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH LA English DT Article DE malaria epidemiology; anopheline bionomics; western Thailand ID FALCIPARUM/VIVAX ENDEMIC AREA; LINKED-IMMUNOSORBENT-ASSAY; PLASMODIUM-VIVAX; ASYMPTOMATIC MALARIA; BARBIROSTRIS COMPLEX; SEASONAL ABUNDANCE; DIPTERA-CULICIDAE; SOUTHERN THAILAND; DIRUS MOSQUITOS; BITING ACTIVITY AB This is the first in a series of papers describing the epidemiology of malaria in an isolated village in western Thailand. The study site was the village of Kong Mong Tha, located in Sangkhla Bun District, Kanchanaburi Province, Thailand. In this paper we present an overview of the study site and results from our adult anopheline mosquito surveillance conducted over 56 consecutive months from June 1999 until January 2004. The collection site, indoor/outdoor location, parity, biting activity and Plasmodium falciparum (Pf) and P. vivax (Pv) infection rates were used to calculate seasonal entomological inoculation rates for the predominant four Anopheles species. A total of 21,566 anophelines representing 28 distinct species and 2 groups that were not identified to species were collected using human bait, with almost 95% of the collection consisting of Anopheles minimus, An. maculatus, An. sawadwongporni and An. barbirostris/campestris. Mosquitoes generally peaked during the wet season, were collected throughout the night, and were collected most often outside (ca. 75%) versus inside (ca. 25%) of houses. Approximately 50% of collected mosquitoes were parous. Overall Plasmodium infection rates were 0.27%, with a total of 16 and 42 pools of Pf- and Pv-positive mosquitoes, respectively. Annual EIRs were 2.3 times higher for Pv than for Pf, resulting in approximately 5.5 and 2.6 infective bites per person per year, respectively. The results suggest An. minimus and An. maculatus are the primary and secondary vectors of Pf and Pv transmission in Kong Mong Tha, while An. sawadwongporni and An. barbirostris/campestris also appear to play a role based on the presence of circumsporozoite protein (CSP) in the head/thorax of the specimens tested. C1 [Zollner, Gabriela; Sattabongkot, Jetsumon; Kankaew, Prasan; Sithiprasasna, Ratana; Coleman, Russell E.] US Army Med Component, Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok, Thailand. [Vaughan, Jefferson A.] Univ N Dakota, Dept Biol, Grand Forks, ND 58202 USA. [Robert, Leon L.] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. [Thimasarn, Krongthong] Minist Publ Hlth, Dept Communicable Dis Control, Malaria Div, Nonthaburi, Thailand. RP Coleman, RE (reprint author), Joint Project Management Off, 1564 Freedman Dr, Ft Detrick, MD 21702 USA. EM Russell.coleman@us.army.mil FU NIH grant [AI48813]; Military Infectious Diseases Research Program of the US Army Medical Research and Materiel Command; Fort Detrick, Maryland; National Research Council Associateship Award at AFRIMS FX The willing assistance of the villagers in Kong Mong Tha is greatly appreciated. We are grateful to Ampornpan Kengluecha, Chalermpol Kumpitak, Chukree Kiattibut, Nantavadee Suwanabun, Patcharee Khongtak, Somporn Chanaimongkol, Somsak Tiangtrong and Suda Ratanawong for providing technical assistance and expertise in the field and laboratory. Funding for this project was provided by the NIH grant AI48813 and by the Military Infectious Diseases Research Program of the US Army Medical Research and Materiel Command, Fort Detrick, Maryland. The work was performed while G Zollner held a National Research Council Associateship Award at AFRIMS. NR 66 TC 0 Z9 0 U1 2 U2 3 PU SOUTHEAST ASIAN MINISTERS EDUC ORGANIZATION PI BANGKOK PA SEAMEO-TROPMED, 420-6 RAJVITHI RD,, BANGKOK 10400, THAILAND SN 0125-1562 J9 SE ASIAN J TROP MED JI Southeast Asian J. Trop. Med. Public Health PD MAY PY 2016 VL 47 IS 3 BP 341 EP 365 PG 25 WC Public, Environmental & Occupational Health; Infectious Diseases; Tropical Medicine SC Public, Environmental & Occupational Health; Infectious Diseases; Tropical Medicine GA DO8DI UT WOS:000378012400001 PM 27405117 ER PT J AU Hoekman, D Springer, YP Barker, CM Barrera, R Blackmore, MS Bradshaw, WE Foley, DH Ginsberg, HS Hayden, MH Holzapfel, CM Juliano, SA Kramer, LD LaDeau, SL Livdahl, TP Moore, CG Nasci, RS Reisen, WK Savage, HM AF Hoekman, D. Springer, Y. P. Barker, C. M. Barrera, R. Blackmore, M. S. Bradshaw, W. E. Foley, D. H. Ginsberg, H. S. Hayden, M. H. Holzapfel, C. M. Juliano, S. A. Kramer, L. D. LaDeau, S. L. Livdahl, T. P. Moore, C. G. Nasci, R. S. Reisen, W. K. Savage, H. M. TI Design for mosquito abundance, diversity, and phenology sampling within the National Ecological Observatory Network SO ECOSPHERE LA English DT Article DE abundance; climate; Culicidae; diversity; global change; long-term monitoring; mosquito; phenology; Special Feature: NEON Design ID WEST-NILE-VIRUS; AEDES-ALBOPICTUS; BORNE DISEASES; KERN COUNTY; CLIMATE; TRAPS; SURVEILLANCE; ENVIRONMENT; CALIFORNIA; CATCHES AB The National Ecological Observatory Network (NEON) intends to monitor mosquito populations across its broad geographical range of sites because of their prevalence in food webs, sensitivity to abiotic factors, and relevance for human health. We describe the design of mosquito population sampling in the context of NEON's long-term continental scale monitoring program, emphasizing the sampling design schedule, priorities, and collection methods. Freely available NEON data and associated field and laboratory samples, will increase our understanding of how mosquito abundance, demography, diversity, and phenology are responding to land use and climate change. C1 [Hoekman, D.; Springer, Y. P.] Natl Ecol Observ Network NEON Inc, 1685 38th St Suite 100, Boulder, CO 80301 USA. [Springer, Y. P.; Nasci, R. S.; Savage, H. M.] US Ctr Dis Control & Prevent, Div Vector Borne Dis, 3156 Rampart Rd, Ft Collins, CO 80521 USA. [Barker, C. M.; Reisen, W. K.] Univ Calif Davis, Sch Vet Med, Ctr Vectorborne Dis, Davis, CA 95616 USA. [Barker, C. M.; Reisen, W. K.] Univ Calif Davis, Sch Vet Med, Dept Pathol Microbiol & Immunol, Davis, CA 95616 USA. [Barrera, R.] US Ctr Dis Control & Prevent, Div Vector Borne Dis, 1324 Calle Canada, San Juan, PR 00969 USA. [Blackmore, M. S.] Valdosta State Univ, Dept Biol, Valdosta, GA 31698 USA. [Bradshaw, W. E.; Holzapfel, C. M.] Univ Oregon, Inst Ecol & Evolut, Eugene, OR 97403 USA. [Foley, D. H.] Walter Reed Army Inst Res, Walter Reed Biosystemat Unit, Div Entomol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. [Ginsberg, H. S.] Univ Rhode Isl, US Geol Survey, Patuxent Wildlife Res Ctr, Coastal Field Stn,PSE, Woodward Hall, Kingston, RI 02881 USA. [Hayden, M. H.] Natl Ctr Atmospher Res, POB 3000, Boulder, CO 80307 USA. [Juliano, S. A.] Illinois State Univ, Sch Biol Sci, Normal, IL 61790 USA. [Kramer, L. D.] New York State Dept Hlth, Arbovirus Lab, Wadsworth Ctr, Slingerlands, NY 12159 USA. [Kramer, L. D.] SUNY Albany, Sch Publ Hlth, Albany, NY 12201 USA. [LaDeau, S. L.] Cary Inst Ecosyst Studies, 2801 Sharon Turnpike, Millbrook, NY 12545 USA. [Livdahl, T. P.] Clark Univ, Dept Biol, Worcester, MA 01610 USA. [Moore, C. G.] Colorado State Univ, Dept Microbiol Immunol & Pathol, 1690 Campus Delivery, Ft Collins, CO 80523 USA. [Hoekman, D.] Southern Nazarene Univ, Dept Biol, 6729 NW 39th Expressway, Bethany, OK 73008 USA. [Nasci, R. S.] North Shore Mosquito Abatement Dist, 117 Northfield Rd, Northfield, IL 60093 USA. RP Hoekman, D (reprint author), Natl Ecol Observ Network NEON Inc, 1685 38th St Suite 100, Boulder, CO 80301 USA.; Hoekman, D (reprint author), Southern Nazarene Univ, Dept Biol, 6729 NW 39th Expressway, Bethany, OK 73008 USA. EM dhoekman@snu.edu OI Foley, Desmond/0000-0001-7525-4601 FU National Science Foundation [EF-1029808] FX The National Ecological Observatory Network is a project sponsored by the National Science Foundation and managed under cooperative agreement by NEON Inc. This material is based upon work supported by the National Science Foundation under Cooperative Service Agreement EF-1029808. Any opinions, findings, conclusions or recommendations expressed here are those of the authors and do not necessarily reflect the views of NEON Inc., the NSF, the United States Centers for Disease Control and Prevention, the United States Geological Survey, the United States Department of the Army, or the United States Department of Defense. Use of trade or product names does not imply endorsement by the U.S. Government. The authors acknowledge K.K. Blevins and C.M. Gibson for contributions to early drafts of the design as well as members of the terrestrial observation system group at NEON for formal and informal input during the iteration process. Comments from two anonymous reviewers improved the manuscript and we are grateful to Dr. E.-L.S. Hinckley for coordinating its review. NR 46 TC 0 Z9 0 U1 11 U2 18 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2150-8925 J9 ECOSPHERE JI Ecosphere PD MAY PY 2016 VL 7 IS 5 AR e01320 DI 10.1002/ecs2.1320 PG 13 WC Ecology SC Environmental Sciences & Ecology GA DN6VS UT WOS:000377215200029 ER PT J AU Springer, YP Hoekman, D Johnson, PTJ Duffy, PA Hufft, RA Barnett, DT Allan, BF Amman, BR Barker, CM Barrera, R Beard, CB Beati, L Begon, M Blackmore, MS Bradshaw, WE Brisson, D Calisher, CH Childs, JE Diuk-Wasser, MA Douglass, RJ Eisen, RJ Foley, DH Foley, JE Gaff, HD Gardner, SL Ginsberg, HS Glass, GE Hamer, SA Hayden, MH Hjelle, B Holzapfel, CM Juliano, SA Kramer, LD Kuenzi, AJ LaDeau, SL Livdahl, TP Mills, JN Moore, CG Morand, S Nasci, RS Ogden, NH Ostfeld, RS Parmenter, RR Piesman, J Reisen, WK Savage, HM Sonenshine, DE Swei, A Yabsley, MJ AF Springer, Yuri P. Hoekman, David Johnson, Pieter T. J. Duffy, Paul A. Hufft, Rebecca A. Barnett, David T. Allan, Brian F. Amman, Brian R. Barker, Christopher M. Barrera, Roberto Beard, Charles B. Beati, Lorenza Begon, Mike Blackmore, Mark S. Bradshaw, William E. Brisson, Dustin Calisher, Charles H. Childs, James E. Diuk-Wasser, Maria A. Douglass, Richard J. Eisen, Rebecca J. Foley, Desmond H. Foley, Janet E. Gaff, Holly D. Gardner, Scott L. Ginsberg, Howard S. Glass, Gregory E. Hamer, Sarah A. Hayden, Mary H. Hjelle, Brian Holzapfel, Christina M. Juliano, Steven A. Kramer, Laura D. Kuenzi, Amy J. LaDeau, Shannon L. Livdahl, Todd P. Mills, James N. Moore, Chester G. Morand, Serge Nasci, Roger S. Ogden, Nicholas H. Ostfeld, Richard S. Parmenter, Robert R. Piesman, Joseph Reisen, William K. Savage, Harry M. Sonenshine, Daniel E. Swei, Andrea Yabsley, Michael J. TI Tick-, mosquito-, and rodent-borne parasite sampling designs for the National Ecological Observatory Network SO ECOSPHERE LA English DT Article DE infectious disease; mosquito; National Ecological Observatory Network; NEON design; parasite; pathogen; reservoir; rodent; sampling design; Special Feature: NEON Design; tick; vector; zoonoses ID WEST-NILE-VIRUS; SIN-NOMBRE-VIRUS; HANTAVIRUS PULMONARY SYNDROME; EMERGING INFECTIOUS-DISEASES; IXODES-SCAPULARIS ACARI; SOUTHWESTERN UNITED-STATES; AMBLYOMMA-AMERICANUM ACARI; FIELD-COLLECTED MOSQUITOS; LAND-USE CHANGE; CLIMATE-CHANGE AB Parasites and pathogens are increasingly recognized as significant drivers of ecological and evolutionary change in natural ecosystems. Concurrently, transmission of infectious agents among human, livestock, and wildlife populations represents a growing threat to veterinary and human health. In light of these trends and the scarcity of long-term time series data on infection rates among vectors and reservoirs, the National Ecological Observatory Network (NEON) will collect measurements and samples of a suite of tick-, mosquito-, and rodent-borne parasites through a continental-scale surveillance program. Here, we describe the sampling designs for these efforts, highlighting sampling priorities, field and analytical methods, and the data as well as archived samples to be made available to the research community. Insights generated by this sampling will advance current understanding of and ability to predict changes in infection and disease dynamics in novel, interdisciplinary, and collaborative ways. C1 [Springer, Yuri P.; Hoekman, David; Barnett, David T.] Natl Ecological Observ Network NEON Inc, 1685 38th St Suite 100, Boulder, CO 80301 USA. [Springer, Yuri P.; Beard, Charles B.; Eisen, Rebecca J.; Nasci, Roger S.; Piesman, Joseph; Savage, Harry M.] US Ctr Dis Control & Prevent, Div Vector Borne Dis, 3150 Rampart Rd, Ft Collins, CO 80521 USA. [Hoekman, David] Southern Nazarene Univ, Dept Biol, 6729 NW 29th Expy, Bethany, OK 73008 USA. [Johnson, Pieter T. J.] Univ Colorado, Dept Ecol & Evolutionary Biol, Ramaley N122, Boulder, CO 80309 USA. [Duffy, Paul A.] Neptune & Co Inc, 1435 Garrison St Suite 100, Lakewood, CO 80215 USA. [Hufft, Rebecca A.] Denver Bot Gardens, 909 York St, Denver, CO 80206 USA. [Allan, Brian F.] Univ Illinois, Dept Entomol, Urbana, IL 61801 USA. [Amman, Brian R.] Natl Ctr Emerging & Zoonot Infect Dis, Div High Consequence Pathogens & Pathol, Viral Special Pathogens Branch, US Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Barker, Christopher M.; Reisen, William K.] Univ Calif Davis, Sch Vet Med, Ctr Vectorborne Dis, Davis, CA 95616 USA. [Barker, Christopher M.; Reisen, William K.] Univ Calif Davis, Sch Vet Med, Dept Pathol Microbiol & Immunol, Davis, CA 95616 USA. [Barrera, Roberto] US Ctr Dis Control & Prevent, Div Vector Borne Dis, 1324 Calle Canada, San Juan, PR 00969 USA. [Beati, Lorenza] Georgia So Coll, Inst Arthropodol & Parasitol, Georgia Ave,Bldg 204,POB 8056, Statesboro, GA 30460 USA. [Begon, Mike] Univ Liverpool, IIB, Liverpool L69 7ZB, Merseyside, England. [Blackmore, Mark S.] Valdosta State Univ, Dept Biol, Valdosta, GA 31698 USA. [Bradshaw, William E.; Holzapfel, Christina M.] Univ Oregon, Inst Ecol & Evolut, Eugene, OR 97403 USA. [Brisson, Dustin] Univ Penn, Dept Biol, Evolut & Ecol Dis Syst Lab, 209 Leidy Labs, 433 S Univ Ave, Philadelphia, PA 19104 USA. [Calisher, Charles H.] Colorado State Univ, Arthropod Borne & Infect Dis Lab, Dept Microbiol Immunol & Pathol, Coll Vet Med & Biomed Sci, 3195 Rampart Rd,Foothills Campus, Ft Collins, CO 80523 USA. [Childs, James E.] Yale Univ, Sch Publ Hlth, Dept Epidemiol & Microbiol, New Haven, CT 06520 USA. [Diuk-Wasser, Maria A.] Columbia Univ, Dept Ecol Evolut & Environm Biol, 1200 Amsterdam Ave, New York, NY 10027 USA. [Douglass, Richard J.; Kuenzi, Amy J.] Montana Tech Univ, Dept Biol Sci, Butte, MT 59701 USA. [Foley, Desmond H.] Walter Reed Army Inst Res, Div Entomol, Walter Reed Biosystemat Unit, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. [Foley, Janet E.] Univ Calif Davis, Sch Vet Med, Dept Med & Epidemiol, Davis, CA 95616 USA. [Gaff, Holly D.; Sonenshine, Daniel E.] Old Dominion Univ, Dept Biol Sci, Norfolk, VA 23529 USA. [Gardner, Scott L.] Univ Nebraska, State Museum, Harold W Manter Lab Parasitol, Lincoln, NE 68588 USA. [Ginsberg, Howard S.] Univ Rhode Isl, PSE, Patuxent Wildlife Res Ctr, US Geol Survey,Coastal Field Stn, Woodward Hall, Kingston, RI 02881 USA. [Glass, Gregory E.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA. [Hamer, Sarah A.] Texas A&M Univ, Dept Vet Integrat Biosci, College Stn, TX 77843 USA. [Hayden, Mary H.] Natl Ctr Atmospher Res, POB 3000, Boulder, CO 80307 USA. [Hjelle, Brian] Univ New Mexico HSC, Dept Pathol, Albuquerque, NM 87131 USA. [Hjelle, Brian] Univ New Mexico HSC, Dept Biol, Albuquerque, NM 87131 USA. [Hjelle, Brian] Univ New Mexico HSC, Dept Mol Genet & Microbiol, Albuquerque, NM 87131 USA. [Juliano, Steven A.] Illinois State Univ, Sch Biol Sci, Normal, IL 61790 USA. [Kramer, Laura D.] New York State Dept Hlth Slingerlands, Arbovirus Labs Wadsworth Ctr, New York, NY 12159 USA. [Kramer, Laura D.] SUNY Albany, Sch Publ Hlth, Albany, NY 12201 USA. [LaDeau, Shannon L.; Ostfeld, Richard S.] Cary Inst Ecosyst Studies, 2801 Sharon Turnpike, Millbrook, NY 12545 USA. [Livdahl, Todd P.] Clark Univ, Dept Biol, Worcester, MA 01610 USA. [Mills, James N.] Emory Univ, Populat Biol Ecol & Evolut Program, 1335 Springdale Rd, Atlanta, GA 30306 USA. [Moore, Chester G.] Colorado State Univ, Dept Microbiol Immunol & Pathol, 1690 Campus Delivery, Ft Collins, CO 80523 USA. [Morand, Serge] Ctr Infectiol Christophe Merieux Laos, CNRS CIRAD AGIRs, Viangchan, Laos. [Ogden, Nicholas H.] Publ Hlth Agcy Canada, 3200 Sicotte, St Hyacinthe, PQ J2S 7C6, Canada. [Parmenter, Robert R.] Valles Caldera Natl Preserve, POB 359, Jemez Springs, NM 87025 USA. [Swei, Andrea] San Francisco State Univ, Dept Biol, San Francisco, CA 94132 USA. [Yabsley, Michael J.] Univ Georgia, Coll Vet Med, Dept Populat Hlth, Warnell Sch Forestry & Nat Resources, Athens, GA 30605 USA. [Yabsley, Michael J.] Univ Georgia, Southeastern Cooperat Wildlife Dis Study, Athens, GA 30605 USA. [Springer, Yuri P.] Venice Bike Fix, 1101 Ocean Front Walk, Venice, CA 90291 USA. RP Springer, YP (reprint author), Natl Ecological Observ Network NEON Inc, 1685 38th St Suite 100, Boulder, CO 80301 USA. EM yurispringer@gmail.com OI Foley, Desmond/0000-0001-7525-4601 FU National Science Foundation; RRA grant [DBI-0752017] FX The NEON is a project sponsored by the National Science Foundation. At the time this paper was written, the project was managed under cooperative agreement by NEON, Inc. The material presented in this paper is based on work supported by the National Science Foundation under Cooperative Service Agreement and RRA grant DBI-0752017. Any opinions, findings, conclusions or recommendations expressed here are those of the authors and do not necessarily reflect the views of NEON, Inc., the National Science Foundation, the U.S. Centers for Disease Control and Prevention, the U.S. Department of the Army, or the U.S. Department of Defense. Similarly, changes to the designs proposed herein during implementation by NEON, Inc. do not necessarily reflect the scientific recommendations of the authors. This article and the designs presented within it were developed and written when Y.P. Springer and D. Hoekman were employed as the disease and insect ecologists, respectively, at NEON, Inc. The authors gratefully acknowledge C.M. Gibson and V.J. McKenzie for their contributions to early versions of these designs, and E.L.S. Hinckley and S.V. Ollinger for publication support. We also thank scientists and technicians of the NEON terrestrial observation systems team for their collaborative efforts to create the larger NEON terrestrial sampling plan of which these designs are a part. W. Barnett assisted with the writing of the power analysis code. Comments from J.R. Sauer, S.R. Campbell, S.C. Elmendorf, E.L.S. Hinckley, K.E. Levan, and two anonymous reviewers improved the manuscript. Any use of trade, firm, or product names is for descriptive purposes only and does not imply endorsement by the U.S. Government. NEON working group members are as follows: Tick and tick-borne parasite technical working group: B. F. Allan, C. B. Beard, L. B. Dustin Brisson, M. A. Diuk-Wasser, R. J. Eisen, H. D. Gaff, S. A. Hamer, N. H. Ogden, R. S. Ostfeld, J. Piesman, D. E. Sonenshine, A. Swei, and M. J. Yabsley; Mosquito and mosquito-borne parasite technical working group: C. M. Barker, R. Barrera, M. S. Blackmore, W. E. Bradshaw, D. H. Foley, H. S. Ginsberg, M. H. Hayden, C. M. Holzapfel, S. A. Juliano, L. D. Kramer, S. L. LaDeau, T. P. Livdahl, C. G. Moore, R. S. Nasci, W. K. Reisen, and H. M. Savage; Rodent-borne parasite technical working group: M. Begon, C. H. Calisher, J. E. Childs, R. J. Douglass, J. E. Foley, S. L. Gardner, G. E. Glass, B. Hjelle, A. J. Kuenzi, J. N. Mills, S. Morand, and R. R. Parmenter. NR 242 TC 1 Z9 1 U1 12 U2 17 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2150-8925 J9 ECOSPHERE JI Ecosphere PD MAY PY 2016 VL 7 IS 5 AR e01271 DI 10.1002/ecs2.1271 PG 40 WC Ecology SC Environmental Sciences & Ecology GA DN6VS UT WOS:000377215200011 ER PT J AU Dunn, JC Kusnezov, N Orr, JD Pallis, M Mitchell, JS AF Dunn, John C. Kusnezov, Nicholas Orr, Justin D. Pallis, Mark Mitchell, Justin S. TI The Boxer's Fracture: Splint Immobilization Is Not Necessary SO ORTHOPEDICS LA English DT Article ID 5TH METACARPAL; SUBCAPITAL FRACTURES; FINGER METACARPAL; NECK; REPOSITION; HAND; 4TH AB Fractures of the fifth metacarpal neck, or boxer's fractures, are common, particularly among young men. Because of the high frequency of this injury, there is a considerable range of treatment options. The purpose of this systematic review was to determine whether reduction and splint or cast immobilization is necessary for fractures of the fifth metacarpal neck. The authors conducted a systematic review of all published studies that randomized these fractures to cast immobilization vs treatment with soft wrap without reduction. Cast immobilization is not superior to soft wrap without reduction in most cases. The study found that reduction and cast immobilization is not necessary for boxer's fractures. C1 [Dunn, John C.; Kusnezov, Nicholas; Orr, Justin D.; Pallis, Mark; Mitchell, Justin S.] William Beaumont Army Med Ctr, Dept Orthopaed Surg, 5005 N Piedras, Ft Bliss, TX 79920 USA. RP Dunn, JC (reprint author), William Beaumont Army Med Ctr, Dept Orthopaed Surg, 5005 N Piedras, Ft Bliss, TX 79920 USA. EM dunnjohnc@gmail.com NR 29 TC 1 Z9 1 U1 1 U2 1 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0147-7447 EI 1938-2367 J9 ORTHOPEDICS JI Orthopedics PD MAY-JUN PY 2016 VL 39 IS 3 BP 188 EP 192 DI 10.3928/01477447-20160315-05 PG 5 WC Orthopedics SC Orthopedics GA DO1DR UT WOS:000377519200042 PM 27018606 ER PT J AU Waterman, BR Martin, KD Cameron, KL Owens, BD Belmont, PJ AF Waterman, Brian R. Martin, Kevin D. Cameron, Kenneth L. Owens, Brett D. Belmont, Philip J., Jr. TI Simulation Training Improves Surgical Proficiency and Safety During Diagnostic Shoulder Arthroscopy Performed by Residents SO ORTHOPEDICS LA English DT Article ID SKILLS; SURGERY; TRIAL AB Although virtual reality simulators have established construct validity, no studies have proven transfer of skills from a simulator to improved in vivo surgical skill. The current authors hypothesized that simulation training would improve residents' basic arthroscopic performance and safety. Twenty-two orthopedic surgery trainees were randomized into simulation or standard practice groups. At baseline testing, all of the participants performed simulator-based testing and a supervised, in vivo diagnostic shoulder arthroscopy with video recording. The simulation group subsequently received 1 hour of total instruction during a 3-month period, and the standard practice group received no simulator training. After intervention, both groups were reevaluated with simulator testing and a second recorded diagnostic shoulder arthroscopy. Two blinded, independent experts evaluated arthroscopic performance using the anatomic checklist, Arthroscopic Surgery Skill Evaluation Tool (ASSET) score, and total elapsed time. All outcome measures were compared within and between groups. After intervention, mean time required by the simulation group to complete the simulator task (30.64 seconds) was 8 +/- 1.2 seconds faster than the time required by the control group (38.64 seconds; P=. 001). Probe distance (51.65 mm) was improved by 41.2 +/- 6.08 mm compared with the control (92.83 mm; P=. 001). When comparing ASSET safety scores, the simulation group was competent (3.29) and significantly better than the control group (3.00; P=. 005) during final arthroscopic testing. This study establishes transfer validity for an arthroscopic shoulder simulator model. Simulator training for residents in training can decrease surgical times, improve basic surgical skills, and confer greater patient safety during shoulder arthroscopy. C1 [Waterman, Brian R.; Martin, Kevin D.; Belmont, Philip J., Jr.] William Beaumont Army Med Ctr, Dept Orthopaed Surg & Rehabil, El Paso, TX 79920 USA. [Cameron, Kenneth L.; Owens, Brett D.] US Mil Acad, Keller Army Hosp, 900 Washington Rd, West Point, NY 10996 USA. RP Owens, BD (reprint author), US Mil Acad, Keller Army Hosp, 900 Washington Rd, West Point, NY 10996 USA. EM owensbrett@gmail.com FU Mitek; US Army Central Simulation Committee FX Drs Waterman, Martin, Cameron, and Belmont have no relevant financial relationships to disclose. Dr Owens is a paid consultant for Mitek.; The authors thank the US Army Central Simulation Committee for support with this investigation. NR 19 TC 1 Z9 1 U1 2 U2 2 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0147-7447 EI 1938-2367 J9 ORTHOPEDICS JI Orthopedics PD MAY-JUN PY 2016 VL 39 IS 3 BP E479 EP E485 DI 10.3928/01477447-20160427-02 PG 7 WC Orthopedics SC Orthopedics GA DO1DR UT WOS:000377519200013 PM 27135460 ER PT J AU Sobarzo, A Stonier, SW Herbert, AS Ochayon, DE Kuehne, AI Eskira, Y Fedida-Metula, S Tali, N Lewis, EC Egesa, M Cose, S Lutwama, JJ Yavelsky, V Dye, JM Lobel, L AF Sobarzo, Ariel Stonier, Spencer W. Herbert, Andrew S. Ochayon, David E. Kuehne, Ana I. Eskira, Yael Fedida-Metula, Shlomit Tali, Neta Lewis, Eli C. Egesa, Moses Cose, Stephen Lutwama, Julius Julian Yavelsky, Victoria Dye, John M. Lobel, Leslie TI Correspondence of Neutralizing Humoral Immunity and CD4 T Cell Responses in Long Recovered Sudan Virus Survivors SO VIRUSES-BASEL LA English DT Article DE Ebola survivors; memory immunity; neutralizing antibodies; cellular immunity ID EBOLA-VIRUS; INFLAMMATORY RESPONSES; CHEMOKINE RECEPTORS; INFECTION; DISEASE; PERSISTENCE; OUTBREAKS; HUMANS; UGANDA; GULU AB Robust humoral and cellular immunity are critical for survival in humans during an ebolavirus infection. However, the interplay between these two arms of immunity is poorly understood. To address this, we examined residual immune responses in survivors of the Sudan virus (SUDV) outbreak in Gulu, Uganda (2000-2001). Cytokine and chemokine expression levels in SUDV stimulated whole blood cultures were assessed by multiplex ELISA and flow cytometry. Antibody and corresponding neutralization titers were also determined. Flow cytometry and multiplex ELISA results demonstrated significantly higher levels of cytokine and chemokine responses in survivors with serological neutralizing activity. This correspondence was not detected in survivors with serum reactivity to SUDV but without neutralization activity. This previously undefined relationship between memory CD4 T cell responses and serological neutralizing capacity in SUDV survivors is key for understanding long lasting immunity in survivors of filovirus infections. C1 [Sobarzo, Ariel; Eskira, Yael; Fedida-Metula, Shlomit; Tali, Neta; Yavelsky, Victoria; Lobel, Leslie] Ben Gurion Univ Negev, Dept Microbiol Immunol & Genet, Fac Hlth Sci, IL-84105 Beer Sheva, Israel. [Stonier, Spencer W.; Herbert, Andrew S.; Kuehne, Ana I.; Dye, John M.] US Army Med Res Inst Infect Dis, Div Virol, 1425 Porter St, Frederick, MD 21701 USA. [Ochayon, David E.; Lewis, Eli C.] Ben Gurion Univ Negev, Dept Clin Biochem & Pharmacol, Fac Hlth Sci, IL-84105 Beer Sheva, Israel. [Egesa, Moses; Cose, Stephen] MRC, Uganda Virus Res Inst, Uganda Res Unit AIDS, POB 49, Entebbe, Uganda. [Egesa, Moses] Makerere Univ, Dept Med Microbiol, Sch Biomed Sci, Coll Hlth Sci, POB 7072, Kampala, Uganda. [Cose, Stephen] London Sch Hyg & Trop Med, Keppel St, London WC1E 7HT, England. [Lutwama, Julius Julian] Emerging & Reemerging Infect Uganda Virus Res In, Dept Arbovirol, POB 49, Entebbe, Uganda. RP Yavelsky, V; Lobel, L (reprint author), Ben Gurion Univ Negev, Dept Microbiol Immunol & Genet, Fac Hlth Sci, IL-84105 Beer Sheva, Israel.; Dye, JM (reprint author), US Army Med Res Inst Infect Dis, Div Virol, 1425 Porter St, Frederick, MD 21701 USA.; Lutwama, JJ (reprint author), Emerging & Reemerging Infect Uganda Virus Res In, Dept Arbovirol, POB 49, Entebbe, Uganda. EM tautau.ariel@gmail.com; spencer.w.stonier2.ctr@mail.mil; anderw.s.herbert.ctr@mail.mil; davidochayon@gmail.com; aikuehne@aol.com; askiray@gmail.com; fedida.metula@gmail.com; netatali20@gmail.com; lewis@bgu.ac.il; m.c.egesa@gmail.com; stephen.cose@lshtm.ac.uk; jjlutwama03@yahoo.com; yavelsky@bgu.ac.il; john.m.dye1.civ@mail.mil; leslie.lobel@gmail.com OI Egesa, Moses/0000-0001-5136-868X; Cose, Stephen/0000-0002-5156-037X FU Defense Threat Reduction Agency [CB3948] FX The authors would like to acknowledge Alison Elliott and Pietro Pala for their assistance with flow cytometry experiments at the Medical Research Council/Uganda Virus Research Institute, Uganda Research Unit on AIDS in Entebbe, Uganda. This work was supported by the Defense Threat Reduction Agency (CB3948). NR 28 TC 0 Z9 0 U1 5 U2 6 PU MDPI AG PI BASEL PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND SN 1999-4915 J9 VIRUSES-BASEL JI Viruses-Basel PD MAY PY 2016 VL 8 IS 5 AR 133 DI 10.3390/v8050133 PG 12 WC Virology SC Virology GA DN9VU UT WOS:000377429600016 ER PT J AU Sliozberg, YR Chantawansri, TL AF Sliozberg, Yelena R. Chantawansri, Tanya L. TI Mechanism resulting in chemical imbalance due to cellular damage associated with mechanoporation: A molecular dynamics study SO CHEMICAL PHYSICS LETTERS LA English DT Article ID TRAUMATIC BRAIN-INJURY; PLASMA-MEMBRANE DISRUPTIONS; LIPID-BILAYERS; PORE FORMATION; FORCE-FIELD; STRAIN-RATE; IN-VITRO; SIMULATIONS; CALCIUM; DEPENDENCE AB To elucidate the mechanism of ion transport through a transmembrane pore, all-atom molecular dynamics simulations were employed. A model membrane where a pore connects the intra- and extra-cellular compartment was considered. Pores with radii of 1.5 nm or less exhibited resealing over the course of 135 ns simulations, and ionic disturbance is minimal. Ion transport through a larger pore (2 nm radius) leads to a substantial change in the intra- and extra-cellular ionic concentrations. The influx of Na+ and Cl- ions down their concentration gradients is greater than the efflux of K+ leading to an osmotic influx of water. (C) 2016 Elsevier B.V. All rights reserved. C1 [Chantawansri, Tanya L.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Sliozberg, Yelena R.] TXC Global Inc, Aberdeen Proving Ground, MD 21005 USA. RP Sliozberg, YR (reprint author), 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21009 USA. EM yelena.r.sliozberg.ctr@mail.mil FU U.S. Army Research Laboratory [W911-QX-14-C0016] FX The authors would like to thank Drs. R.M. Elder, T. Piehler, J. Vettel, and P. Franaszczuk for useful discussion. Calculations were performed using the DOD Supercomputing Resource Center located at the Air Force and Navy Laboratories. The research reported in this document was performed in connection with contract/instrument W911-QX-14-C0016 with the U.S. Army Research Laboratory. The views and conclusions contained in this document are those of TKC Global Inc. and the U.S. Army Research Laboratory. Citation of manufacturer's or trade names does not constitute an official endorsement or approval of the use thereof. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation hereon. NR 41 TC 0 Z9 0 U1 5 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2614 EI 1873-4448 J9 CHEM PHYS LETT JI Chem. Phys. Lett. PD MAY PY 2016 VL 651 BP 39 EP 45 DI 10.1016/j.cplett.2016.03.018 PG 7 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA DN6RK UT WOS:000377203300008 ER PT J AU Kragh, JF Dubick, MA Aden, JK McKeague, AL Rasmussen, TE Baer, DG Blackbourne, LH AF Kragh, John F., Jr. Dubick, Michael A. Aden, James K., III McKeague, Anne L. Rasmussen, Todd E. Baer, David G. Blackbourne, Lorne H. TI US Military Experience From 2001 to 2010 With Extremity Fasciotomy in War Surgery SO MILITARY MEDICINE LA English DT Article ID INJURY AB Introduction: After trauma, compartment syndrome of the extremities is a common, disabling, and-if managed suboptimally-lethal problem. Its treatment by surgical fasciotomy continues to be useful but controversial. The purpose of this survey is to measure survival and fasciotomy in a large trauma system to characterize trends and to determine if fasciotomy is associated with improved survival. Methods: We retrospectively surveyed data from a military trauma registry for U.S. casualties from 2001 to 2010. Casualties had extremity injury or extremity fasciotomy. We associated survival and fasciotomy. Results: Of 17,166 casualties in the total study, 19% (3,313) had fasciotomy and 2.8% (481) had compartment syndrome. Annual fasciotomy rates started at 0% (2001) and rose to 26% (2010). For all casualties, the survival rate initially was high (100%) but decreased steadily until its nadir (96.4%) in 2005. Thereafter, it increased to make a V-shaped trend with reversal occurring after fielding two interventions within the trauma system specifically for casualties at risk for fasciotomy-tourniquet use and a fasciotomy education program. Conclusions: Over a decade of war, the survival rate of extremity injured casualties was associated with two trauma system interventions-tourniquet usage and a fasciotomy education program. The current example of measuring implementation of initiatives may be useful as a model for future attempted improvements in health care. C1 [Kragh, John F., Jr.; Dubick, Michael A.; Aden, James K., III; Baer, David G.] US Army, Inst Surg Res, JBSA, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. [McKeague, Anne L.] Z Med Corp, 4 Fairfield Blvd, Wallingford, CT 06492 USA. [Rasmussen, Todd E.] US Army, Med Res & Mat Command, Ft Detrick, MD 21702 USA. [Blackbourne, Lorne H.] San Antonio Mil Med Ctr, JBSA, Dept Surg, Ft Sam Houston, TX 78234 USA. RP Kragh, JF (reprint author), US Army, Inst Surg Res, JBSA, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. FU USAISR; Defense Health Program [201105] FX We acknowledge the DoD Trauma Registry's staff including Susan A. West, BSN, and Janet S. Schadee for providing data for this survey. Ralph W. Sweet, RN, MHS, Research Nurse, USAISR, helped in data analysis and survey management. Otilia Sanchez aided in manuscript preparation. This project was funded with internal USAISR funds and the Defense Health Program (Proposal 201105: Operational system management and postmarket surveillance of hemorrhage control devices used in medical care of U.S. servicepersons in the current war). NR 14 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAY PY 2016 VL 181 IS 5 BP 463 EP 468 DI 10.7205/MILMED-D-15-00058 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA DN5MZ UT WOS:000377114400013 PM 27136654 ER PT J AU Pugh, MJ Jaramillo, CA Leung, KW Faverio, P Fleming, N Mortensen, E Amuan, ME Wang, CP Eapen, B Restrepo, M Morris, MJ AF Pugh, Mary Jo Jaramillo, Carlos A. Leung, Kar-wei Faverio, Paola Fleming, Nicholas Mortensen, Eric Amuan, Megan E. Wang, Chen-Pin Eapen, Blessen Restrepo, Marcos Morris, Michael J. TI Increasing Prevalence of Chronic Lung Disease in Veterans of the Wars in Iraq and Afghanistan SO MILITARY MEDICINE LA English DT Article ID US MILITARY PERSONNEL; OPERATION ENDURING FREEDOM; RESPIRATORY SYMPTOMS; PARTICULATE MATTER; SOUTHWEST ASIA; DEPLOYMENT; HEALTH; SOLDIERS; INJURY; PNEUMONIA AB Research from the wars in Afghanistan and Iraq have focused on traumatic brain injury (TBI) and mental health conditions; however, it is becoming clear that other health concerns, such as respiratory illnesses, warrant further scientific inquiry. Early reports from theater and postdeployment health assessments suggested an association with deployment-related exposures (e.g., sand, burn pits, chemical, etc.) and new-onset respiratory symptoms. We used data from Veterans Affairs medical encounters between fiscal years 2003 and 2011 to identify trends in chronic obstructive pulmonary disease, asthma, and interstitial lung disease in veterans. We used data from Veterans Affairs and Department of Defense sources to identify sociodemographic (age, sex, race), military (e.g., service branch, multiple deployments) and clinical characteristics (TBI, smoking) of individuals with and without chronic lung diseases. Generalized estimating equations found significant increases over time for chronic obstructive pulmonary disease and asthma in both unadjusted and adjusted analyses. Trends for interstitial lung disease were significant only in adjusted analyses. Age, smoking, and TBI were also significantly associated with chronic lung diseases; however, multiple deployments were not associated. Research is needed to identify which characteristics of deployment-related exposures are linked with chronic lung disease. C1 [Pugh, Mary Jo; Jaramillo, Carlos A.; Eapen, Blessen; Restrepo, Marcos] South Texas Vet Hlth Care Syst, 7400 Merton Minter Blvd, San Antonio, TX 78229 USA. [Pugh, Mary Jo; Jaramillo, Carlos A.; Leung, Kar-wei; Fleming, Nicholas; Wang, Chen-Pin; Eapen, Blessen; Restrepo, Marcos] Univ Texas Hlth Sci Ctr San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA. [Faverio, Paola] Univ Milano Bicocca, AO San Gerardo, Clin Pneumol, Dept Hlth Sci, Via Pergolesi 22, Monza, Italy. [Mortensen, Eric] North Texas Vet Hlth Care Syst, 4500 South Lancaster Rd, Dallas, TX 75216 USA. [Amuan, Megan E.] Edith Nourse Rogers VA Med Ctr, 200 Springs Rd, Bedford, MA 01730 USA. [Morris, Michael J.] Uniformed Serv Univ Hlth Sci, Brooke Army Med Ctr, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. RP Pugh, MJ (reprint author), South Texas Vet Hlth Care Syst, 7400 Merton Minter Blvd, San Antonio, TX 78229 USA.; Pugh, MJ (reprint author), Univ Texas Hlth Sci Ctr San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA. OI Pugh, Mary Jo/0000-0003-4196-7763; Mortensen, Eric/0000-0002-3880-5563 FU VA Health Services Research and Development Service [DHI 09-237] FX Data were obtained with the assistance of the VA Office of Environmental Epidemiology for the Operation Enduring Freedom/Operation Iraqi Freedom Roster file. This study was funded by the VA Health Services Research and Development Service (DHI 09-237). The content, of this article is solely the responsibility of the authors and does not necessarily reflect the official views of the Veterans' Health Administration or the Department of Defense. The funding organizations had no role in the design and conduct of die study; the collection, management, analysis, and interpretation of the data; or the preparation, review, or approval of the manuscript. This retrospective data study received approval including a waiver of informed consent and Health Insurance Portability and Accountability Act authorization by the institutional review boards of the University of Texas Health Science Center San Antonio and the Edith Nourse Rogers Memorial VA Hospital. NR 27 TC 0 Z9 0 U1 1 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAY PY 2016 VL 181 IS 5 BP 476 EP 481 DI 10.7205/MILMED-D-15-00035 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA DN5MZ UT WOS:000377114400015 PM 27136656 ER PT J AU Fulton, LV Fabich, RA Bhatta, J Fletcher, B Leininger, K Lienesch, K Rodriguez, TA Coyner, JL Johnson, AD O'Sullivan, J AF Fulton, Lawrence V. Fabich, Robert A., Jr. Bhatta, Jeevan Fletcher, Brandon Leininger, Kirby Lienesch, Kevin Rodriguez, Thais A. Coyner, Jennifer L. Johnson, Arthur D. O'Sullivan, Joseph TI Comparison of Resuscitative Protocols for Bupropion Overdose Using Lipid Emulsion in a Swine Model SO MILITARY MEDICINE LA English DT Article ID INFUSION; BUPIVACAINE; PROLONGATION; TOXICITY AB Aims: The aim of this study was to investigate the effects of different treatment combinations on bupropion recovery as well as time to return of spontaneous circulation. Methods:We conducted an eight group, randomized, experiment to evaluate combinations of epinephrine, vasopressin, and lipids on the restoration of cardiac function in Yorkshire pigs. After tracking the animals' baseline vitals for 10 minutes, we injected the animals with bupropion (35 mg/kg) and initiated a randomized protocol 2 minutes after cardiac arrest. Results: Results demonstrated that animal survival given treatment combinations including epinephrine were statistically superior to any other group (p < 0.001, Fishers' exact test). The odds of survival with use of epinephrine vs. other options were 22:1 (5.47, 88.43). Further, all animals receiving only lipids died. Cox survival analysis with bootstrapped parameter estimates provided evidence that the rapidity of cardiac recovery was maximized with a combination of epinephrine and lipids (p < 0.05). Conclusions: Lipids may require an additional chemical catalyst in order to be effective in cardiac recovery. Epinephrine and lipids combined shortened recovery time for surviving animals. C1 [Fulton, Lawrence V.] Texas Tech, 703 Flint Ave, Lubbock, TX 79409 USA. [Fulton, Lawrence V.] Texas Tech Univ Hlth Sci Syst, 703 Flint Ave, Lubbock, TX 79409 USA. [Fabich, Robert A., Jr.; Bhatta, Jeevan; Fletcher, Brandon; Leininger, Kirby; Lienesch, Kevin; Rodriguez, Thais A.; Coyner, Jennifer L.; Johnson, Arthur D.; O'Sullivan, Joseph] US Army, Grad Program Anesthesia Nursing, Dunlap Hall,3490 Forage Ave, Ft Sam Houston, TX 78234 USA. US Dept Def, Anim Lab, Ft Sam Houston, TX USA. RP Fulton, LV (reprint author), Texas Tech, 703 Flint Ave, Lubbock, TX 79409 USA.; Fulton, LV (reprint author), Texas Tech Univ Hlth Sci Syst, 703 Flint Ave, Lubbock, TX 79409 USA. FU Tri-Service Nursing Research Program FX This research was funded under a grant from the Tri-Service Nursing Research Program. NR 20 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAY PY 2016 VL 181 IS 5 BP 482 EP 487 DI 10.7205/MILMED-D-15-00218 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA DN5MZ UT WOS:000377114400016 PM 27136657 ER PT J AU Campagna, JDA Bowsher, B AF Campagna, John D. A. Bowsher, Barbara TI Prevalence of Body Dysmorphic Disorder and Muscle Dysmorphia Among Entry-Level Military Personnel SO MILITARY MEDICINE LA English DT Article ID ENHANCING MEDICAL TREATMENTS; DIETARY-SUPPLEMENTS; ANOREXIA-NERVOSA; EATING-DISORDERS; IMAGE; WEIGHTLIFTERS; COMORBIDITY; SOLDIERS; MEN; SYMPTOMATOLOGY AB Objective: To determine the prevalence of body dysmorphic disorder (BDD) and muscle dysmorphia (MD) in enlisted U.S. military personnel; and secondarily, to determine supplement use and relationship with BDD and MD. Methods: A survey of advanced individual training of tri-service personnel at Fort Sam Houston, Texas, was performed combining the dysmorphia concern questionnaire, the MD symptom questionnaire, a supplement questionnaire, and demographic factors. Results: Of the 1,320 service members approached, 1,150 (87.1%) completed the survey. The majority of participants were male, 62.8% (n = 722) and Army soldiers 59.0% (n = 679). The prevalence rate of BDD was 13.0% in males and 21.7% in females. The prevalence of MD was 12.7% in males and 4.2% in females. There was a strong correlation between having BDD and using supplements to get thinner (odds ratio 5.1; 95% confidence interval 3.4-7.8; p < 0.001) and MD to get more muscular (odds ratio 5.4; 95% confidence interval 3.5- 8.3; p < 0.001). Conclusions: Our study shows a higher than expected prevalence rate of BDD and MD in service members. This indicates a need for increased awareness of dysmorphias in mental health providers, primary care providers, and commanders and justifies further military specific BDD and MD research. C1 [Campagna, John D. A.] Womack Army Med Ctr, Dept Pediat, 2817 Reilly Rd, Ft Bragg, NC 28310 USA. [Bowsher, Barbara] San Antonio Mil Med Ctr, Dept Pediat, Adolescent Med, MCHK PE,Joint Base San Antonio, 3100 Schofield Rd,Bldg 119, Ft Sam Houston, TX 78234 USA. RP Campagna, JDA (reprint author), Womack Army Med Ctr, Dept Pediat, 2817 Reilly Rd, Ft Bragg, NC 28310 USA. NR 56 TC 0 Z9 0 U1 9 U2 11 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAY PY 2016 VL 181 IS 5 BP 494 EP 501 DI 10.7205/MILMED-D-15-00118 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA DN5MZ UT WOS:000377114400018 PM 27136659 ER PT J AU Dozier, J Bair, EH Davis, RE AF Dozier, Jeff Bair, Edward H. Davis, Robert E. TI Estimating the spatial distribution of snow water equivalent in the world's mountains SO WILEY INTERDISCIPLINARY REVIEWS-WATER LA English DT Review ID SIR-C/X-SAR; COLORADO RIVER-BASIN; PASSIVE MICROWAVE; ALBEDO PRODUCT; UNITED-STATES; COVER; DEPTH; MODEL; MODIS; PRECIPITATION AB Estimating the spatial distribution of snow water equivalent (SWE) in mountainous terrain is currently the most important unsolved problem in snow hydrology. Several methods can estimate the amount of snow throughout a mountain range: (1) Spatial interpolation from surface sensors constrained by remotely sensed snow extent provides a consistent answer, with uncertainty related to extrapolation to unrepresented locations. (2) The remotely sensed date of disappearance of snow is combined with a melt calculation to reconstruct the SWE back to the last significant snowfall. (3) Passive microwave sensors offer real-time global SWE estimates but suffer from several problems like subpixel variability in the mountains. (4) A numerical model combined with assimilated surface observations produces SWE at 1-km resolution at continental scales, but depends heavily on a surface network. (5) New methods continue to be explored, for example, airborne LiDAR altimetry provides direct measurements of snow depth, which are combined with modelled snow density to estimate SWE. While the problem is aggressively addressed, the right answer remains elusive. Good characterization of the snow is necessary to make informed choices about water resources and adaptation to climate change and variability. (C) 2016 Wiley Periodicals, Inc. C1 [Dozier, Jeff] Univ Calif Santa Barbara, Bren Sch Environm Sci & Management, Santa Barbara, CA 93106 USA. [Bair, Edward H.] Univ Calif Santa Barbara, Earth Res Inst, Santa Barbara, CA 93106 USA. [Davis, Robert E.] US Army, Cold Reg Res & Engn Lab, Hanover, NH USA. RP Dozier, J (reprint author), Univ Calif Santa Barbara, Bren Sch Environm Sci & Management, Santa Barbara, CA 93106 USA. EM dozier@ucsb.edu OI Dozier, Jeff/0000-0001-8542-431X NR 82 TC 2 Z9 2 U1 6 U2 11 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA EI 2049-1948 J9 WIRES-WATER JI Wiley Interdiscip. Rev.-Water PD MAY-JUN PY 2016 VL 3 IS 3 BP 461 EP 474 DI 10.1002/wat2.1140 PG 14 WC Water Resources SC Water Resources GA DN5QT UT WOS:000377125900009 ER PT J AU Fan, XL Zhu, YJ Luo, C Suo, LM Lin, Y Gao, T Xu, K Wang, CS AF Fan, Xiulin Zhu, Yujie Luo, Chao Suo, Liumin Lin, Yan Gao, Tao Xu, Kang Wang, Chunsheng TI Pomegranate-Structured Conversion-Reaction Cathode with a Built-in Li Source for High-Energy Li-Ion Batteries SO ACS NANO LA English DT Article DE conversion-reaction cathode materials; prelithiation; transition metal fluorides; FeF3 ID FLUORIDE THIN-FILMS; IRON FLUORIDE; ELECTRODE MATERIALS; LITHIUM BATTERIES; METAL FLUORIDES; REACTION-MECHANISMS; ANODE MATERIAL; CARBON MATRIX; NI-C; NANOCOMPOSITE AB Transition metal fluorides (such as FeF3 or CoF2) promise significantly higher theoretical capacities (>571 mAh g(-1)) than the cathode materials currently used in Li-ion batteries. However, their practical application faces major challenges that include poor electrochemical reversibility induced by the repeated bondbreaking and formation and the accompanied volume changes and the difficulty of building an internal Li source within the material so that a full Li-ion cell could be assembled at a discharged state without inducing further technical risk and cost issues. In this work, we effectively addressed these challenges by designing and synthesizing, via an aerosolspray pyrolysis technique, a pomegranate structured nanocomposite FeM/LiF/C (M = Co, Ni), in which 2-3 mn carbon-coated FeM nanoparticles (similar to 10 nm in diameter) and LiF nanoparticles (similar to 20 nm) are uniformly embedded in a porous carbon sphere matrix (100-1000 nm). This uniquely architectured nanocomposite was made possible by the extremely short pyrolysis time (similar to 1 s) and carbon coating in a high-temperature furnace, which prevented the overgrowth of FeM and LiF in the primordial droplet that serves as the carbon source. The presence of Ni or Co in FeM/LiF/C effectively suppresses the formation of Fe3C and further reduces the metallic particle size. The pomegranate architecture ensures the intimate contact among FeM, LiF, and C, thus significantly enhancing the conversion-reaction kinetics, while the nanopores inside the pomegranate-like carbon matrix, left by solvent evaporation during the pyrolysis, effectively accommodate the volume change of FeM/LiF during charge/discharge. Thus, the FeM/LiF/C nanocomposite shows a high specific capacity of >300 mAh g(-1) for more than 100 charge/discharge cycles, which is one of the best performances among all of the prelithiated metal fluoride cathodes ever reported. The pomegranate-structured FeM/LiF/C with its built-in Li source provides an inspiration to the practical application of conversion-reaction-type chemistries as next-generation cathode materials for high-energy density Li-ion batteries. C1 [Fan, Xiulin; Zhu, Yujie; Luo, Chao; Suo, Liumin; Lin, Yan; Gao, Tao; Wang, Chunsheng] Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA. [Xu, Kang] US Army Res Lab, Electrochem Branch, Power & Energy Div, Sensor & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Wang, CS (reprint author), Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA.; Xu, K (reprint author), US Army Res Lab, Electrochem Branch, Power & Energy Div, Sensor & Electron Devices Directorate, Adelphi, MD 20783 USA. EM conrad.k.xu.civ@mail.mil; cswang@umd.edu RI Wang, Chunsheng/H-5767-2011 OI Wang, Chunsheng/0000-0002-8626-6381 FU Army Research Lab [W911NF1420031]; Maryland NanoCenter and its NispLab FX This work was supported by the Army Research Lab under Award Number W911NF1420031. The authors gratefully acknowledge the support of the Maryland NanoCenter and its NispLab. The highly pure fluorinated solvents were provided by Drs. Ron Hendershot and Joe Sundstrom of Daikin America. NR 62 TC 3 Z9 3 U1 30 U2 85 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1936-0851 EI 1936-086X J9 ACS NANO JI ACS Nano PD MAY PY 2016 VL 10 IS 5 BP 5567 EP 5577 DI 10.1021/acsnano.6b02309 PG 11 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA DN1KQ UT WOS:000376825100076 PM 27163232 ER PT J AU Wu, J Jiang, Q Chen, SM Tang, MC Mazur, YI Maidaniuk, Y Benamara, M Semtsiv, MP Masselink, WT Sablon, KA Salamo, GJ Liu, HY AF Wu, Jiang Jiang, Qi Chen, Siming Tang, Mingchu Mazur, Yuriy I. Maidaniuk, Yurii Benamara, Mourad Semtsiv, Mykhaylo P. Masselink, W. Ted Sablon, Kimberly A. Salamo, Gregory J. Liu, Huiyun TI Monolithically Integrated InAs/GaAs Quantum Dot Mid-Infrared Photodetectors on Silicon Substrates SO ACS PHOTONICS LA English DT Article DE quantum dots; infrared photodetectors; silicon; molecular beam epitaxy ID INFRARED PHOTODETECTORS; ENERGY RELAXATION; GE SUBSTRATE; LASERS; EPITAXY; HGCDTE AB High-performance, multispectral, and large-format infrared focal plane arrays are the long-demanded third-generation infrared technique for hyperspectral imaging, infrared spectroscopy, and target identification. A promising solution is to monolithically integrate infrared photodetectors on a silicon platform, which offers not only low-cost but high-resolution focal plane arrays by taking advantage of the well-established Si-based readout integrated circuits. Here, we report the first InAs/GaAs quantum dot (QD) infrared photodetectors monolithically integrated on silicon substrates by molecular beam epitaxy. The III-V photodetectors are directly grown on silicon substrates by using a GaAs buffer, which reduces the threading dislocation density to similar to 10(6) cm(-2). The high-quality QDs grown on Si substrates have led to long photocarrier relaxation time and low dark current density. Mid-infrared photodetection up to similar to 8 mu m is also achieved at 80 K. This work demonstrates that photodetectors can directly be integrated with silicon readout circuitry for realizing large-format focal plane arrays as well as mid-infrared photonics in silicon. C1 [Wu, Jiang; Jiang, Qi; Chen, Siming; Tang, Mingchu; Liu, Huiyun] UCL, Dept Elect & Elect Engn, London WC1E 7JE, England. [Mazur, Yuriy I.; Maidaniuk, Yurii; Benamara, Mourad; Salamo, Gregory J.] Univ Arkansas, Inst Nanosci & Engn, Fayetteville, AR 72701 USA. [Semtsiv, Mykhaylo P.; Masselink, W. Ted] Humboldt Univ, Dept Phys, Newtonstr 15, D-12489 Berlin, Germany. [Sablon, Kimberly A.] US Army, Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RP Wu, J (reprint author), UCL, Dept Elect & Elect Engn, London WC1E 7JE, England. EM jiang.wu@ucl.ac.uk RI Liu, Huiyun/H-5439-2011 FU National Science Foundation of the U.S. (EPSCoR) [OIA-1457888]; Royal Society FX The authors acknowledge the support of the National Science Foundation of the U.S. (EPSCoR Grant No. OIA-1457888). H.L. would like to thank The Royal Society for funding his University Research Fellowship. NR 32 TC 0 Z9 0 U1 8 U2 27 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 2330-4022 J9 ACS PHOTONICS JI ACS Photonics PD MAY PY 2016 VL 3 IS 5 BP 749 EP 753 DI 10.1021/acsphotonics.6b00076 PG 5 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Optics; Physics, Applied; Physics, Condensed Matter SC Science & Technology - Other Topics; Materials Science; Optics; Physics GA DM4RF UT WOS:000376333700004 ER PT J AU Brouillette, C Smith, W Shende, C Gladding, Z Farquharson, S Morris, RE Cramer, JA Schmitigal, J AF Brouillette, Carl Smith, Wayne Shende, Chetan Gladding, Zack Farquharson, Stuart Morris, Robert E. Cramer, Jeffrey A. Schmitigal, Joel TI Analysis of Twenty-Two Performance Properties of Diesel, Gasoline, and Jet Fuels Using a Field-Portable Near-Infrared (NIR) Analyzer SO APPLIED SPECTROSCOPY LA English DT Article DE Fuel analysis; fuel properties; fuel analyzer; near-infrared spectroscopy; NIR ID PARTIAL LEAST-SQUARES; FT-IR; RAMAN-SPECTROSCOPY; PETROLEUM FUELS; OCTANE NUMBERS AB The change in custody of fuel shipments at depots, pipelines, and ports could benefit from an analyzer that could rapidly verify that properties are within specifications. To meet this need, the design requirements for a fuel analyzer based on near-infrared (NIR) spectroscopy, such as spectral region and resolution, were examined. It was found that the 1000 to 1600nm region, containing the second CH overtone and combination vibrational modes of hydrocarbons, provided the best near-infrared to fuel property correlations when path length was taken into account, whereas 4cm(-1) resolution provided only a modest improvement compared to 16cm(-1) resolution when four or more latent variables were used. Based on these results, a field-portable near-infrared fuel analyzer was built that employed an incandescent light source, sample compartment optics to hold 2mL glass sample vials with approximate to 1cm path length, a transmission grating, and a 256 channel InGaAs detector that measured the above stated wavelength range with 5-6nm (approximate to 32cm(-1)) resolution. The analyzer produced high signal-to-noise ratio (SNR) spectra of samples in 5s. Twenty-two property correlation models were developed for diesel, gasoline, and jet fuels with root mean squared error of correlation - cross-validated values that compared favorably to corresponding ASTM reproducibility values. The standard deviations of predicted properties for repeat measurements at 4, 24, and 38? were often better than ASTM documented repeatability values. The analyzer and diesel property models were tested by measuring seven diesel samples at a local ASTM certification laboratory. The standard deviations between the analyzer determined values and the ASTM measured values for these samples were generally better than the model root mean squared error of correlationcross-validated values for each property. C1 [Brouillette, Carl; Smith, Wayne; Shende, Chetan; Gladding, Zack; Farquharson, Stuart] Real Time Analyzers Inc, 362 Ind Pk Rd,8, Middletown, CT USA. [Morris, Robert E.; Cramer, Jeffrey A.] Naval Res Lab, Washington, DC 20375 USA. [Schmitigal, Joel] US Army, TARDEC, Warren, MI USA. RP Farquharson, S (reprint author), Real Time Analyzers Inc, 362 Ind Pk Rd,8, Middletown, CT USA. EM stu@rta.biz FU US Army SBIR program [W56HZV-13-C-0296]; US Army; US Navy and Defense Logistics Agency [W56HZV-14-C-0106] FX Real-Time Analyzers, Inc. is grateful for the support provided by the US Army SBIR program (grant number W56HZV-13-C-0296) and the US Army in conjunction with the US Navy and Defense Logistics Agency (grant number W56HZV-14-C-0106) in developing the portable fuel analyzer. NR 16 TC 0 Z9 0 U1 7 U2 7 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-7028 EI 1943-3530 J9 APPL SPECTROSC JI Appl. Spectrosc. PD MAY PY 2016 VL 70 IS 5 SI SI BP 746 EP 755 DI 10.1177/0003702816638279 PG 10 WC Instruments & Instrumentation; Spectroscopy SC Instruments & Instrumentation; Spectroscopy GA DM3XU UT WOS:000376280800003 PM 27006025 ER PT J AU Sugiharto, VA Murphy, JR Turell, MJ Olsen, CH Stewart, VA Colacicco-Mayhugh, MG Grieco, JP Achee, NL AF Sugiharto, Victor A. Murphy, Jittawadee R. Turell, Michael J. Olsen, Cara H. Stewart, V. Ann Colacicco-Mayhugh, Michelle G. Grieco, John P. Achee, Nicole L. TI Dengue Virus-1 Infection Did Not Alter the Behavioral Response of Aedes aegypti (Diptera: Culicidae) to DEET SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE Aedes aegypti; DEET; behavior; dengue ID INSECT REPELLENT DEET; LA-CROSSE VIRUS; FEEDING-BEHAVIOR; SINDBIS VIRUS; MOSQUITOS; ALBOPICTUS; SYSTEM; REPLICATION; TRISERIATUS; RECEPTORS AB No licensed vaccine or antiviral drug against dengue virus (DENV) is available; therefore, most of the effort to prevent this disease is focused on reducing vector-host interactions. One of the most widely accepted methods of blocking vector-human contact is to use insect repellents to interfere with mosquito host-seeking behavior. Some arboviruses can replicate in the nervous system of the vector, raising the concern that arboviral infection may alter the insect behavioral response toward chemical stimuli. Three different Aedes aegypti (L.) mosquito cohorts: DENV-1-injected, diluent-injected, and uninjected were subjected to behavioral tests using a high-throughput screening system with 2.5% DEET and 0.14% DEET on 1, 4, 7, 10, 14, and 17 d postinjection. All test cohorts exhibited significant contact irritant or escape responses when they were exposed to 2.5% or 0.14% DEET. However, we found no biologically relevant irritancy response change in DENV-1-infected Ae. aegypti mosquitoes when they were exposed to DEET. Further studies evaluating the effects of other arboviral infections on insect repellents activity are necessary in order to provide better recommendation on the prevention of vector-borne disease transmission. C1 [Sugiharto, Victor A.; Murphy, Jittawadee R.; Olsen, Cara H.; Stewart, V. Ann; Grieco, John P.; Achee, Nicole L.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biostat, Bethesda, MD 20814 USA. [Turell, Michael J.] US Army, Med Res Inst Infect Dis, Div Virol, Dept Vector Assessment, Ft Detrick, MD 21702 USA. [Colacicco-Mayhugh, Michelle G.; Grieco, John P.] Med Countermeasure Syst, Ft Detrick, MD 21702 USA. [Achee, Nicole L.] Univ Notre Dame, Eck Inst Global Hlth, Dept Biol Sci, Galvin Life Sci Ctr 239, Notre Dame, IN 46556 USA. RP Sugiharto, VA (reprint author), Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biostat, Bethesda, MD 20814 USA. EM victor.sugiharto@usuhs.edu; jittawadee.murphy@usuhs.edu; mturell@erols.com; cara.olsen@usuhs.edu; ann.stewart@usuhs.edu; michelle.g.colaciccomayhugh.mil@mail.mil; jgrieco@nd.edu; nachee@nd.edu FU Uniformed Services University of the Health Sciences [R08701, T0872211113] FX We would like to thank our colleagues at the Entomology and the Viral Diseases Branches at the Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD, especially E. Rowton, J. Richardson, S. Davidson, and T. Rowland for the use of the WRAIR containment facility, providing Ae. aegypti mosquito populations, and the DENV-1 stock. We would also like to thank K. Chauhan of USDA for providing neat-grade DEET and W. Ching and C. Chao of Naval Medical Research Center for their generosity in lending their Applied Biosystem 7500 Fast RealTime PCR Machine. This study was supported by the Uniformed Services University of the Health Sciences grants R08701 and T0872211113. NR 36 TC 1 Z9 1 U1 3 U2 6 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-2585 EI 1938-2928 J9 J MED ENTOMOL JI J. Med. Entomol. PD MAY PY 2016 VL 53 IS 3 BP 687 EP 691 DI 10.1093/jme/tjw030 PG 5 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA DM6II UT WOS:000376454800029 PM 27026163 ER PT J AU Obenauer, PJ Rueda, LM El-Hossary, SS Watany, N Stoops, CA Fakoli, LS Bolay, FK Diclaro, JW AF Obenauer, P. J. Rueda, L. M. El-Hossary, S. S. Watany, N. Stoops, C. A. Fakoli, L. S. Bolay, F. K. Diclaro, J. W., II TI New Records and Updated Checklist of Phlebotomine Sand Flies (Diptera: Psychodidae) From Liberia SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE Leishmaniasis; Phlebotomus; Sergentomyia; West Africa ID SANDFLIES; LEISHMANIASIS; BIOLOGY; COMPLEX; GHANA AB Phlebotomine sand flies from three counties in Liberia were collected from January 2011 to July 2013. In total, 3,118 sand flies were collected: 18 species were identified, 13 of which represented new records for Liberia. An updated taxonomic checklist is provided with a brief note on sand fly biology, and the disease vector potential for species is discussed. C1 [Obenauer, P. J.] US Navy, 1600 Clifton Rd,649,Bldg 23,Off 9-117, Atlanta, GA 30329 USA. [Obenauer, P. J.] Ctr Dis Control & Prevent, Marine Corps Publ Hlth Ctr Det, 1600 Clifton Rd,649,Bldg 23,Off 9-117, Atlanta, GA 30329 USA. [Rueda, L. M.; El-Hossary, S. S.; Watany, N.] Walter Reed Army Inst Res, Walter Reed Biosystemat Unit, Entomol Branch, Silver Spring, MD USA. [Rueda, L. M.; El-Hossary, S. S.; Watany, N.] Adjacent Abbassa Fever Hosp, Imtidad Ramses St, Abbassa 11517, Egypt. [Diclaro, J. W., II] US Navy, Med Res Unit 3, Cairo, Egypt. [Stoops, C. A.] US Navy, Med Res Unit Lima Peru 6, 3230 Lima Pl, Washington, DC 20521 USA. [Fakoli, L. S.; Bolay, F. K.] Liberian Inst Biomed Res, POB 31, Monrovia, Liberia. RP Obenauer, PJ (reprint author), US Navy, 1600 Clifton Rd,649,Bldg 23,Off 9-117, Atlanta, GA 30329 USA.; Obenauer, PJ (reprint author), Ctr Dis Control & Prevent, Marine Corps Publ Hlth Ctr Det, 1600 Clifton Rd,649,Bldg 23,Off 9-117, Atlanta, GA 30329 USA. EM Yry3@cdc.gov; ruedapol@si.edu; shabaanelhossary57@yahoo.com; Noha.Watany.eg@med.navy.mil; craig.a.stoops.mil@mail.mil; lawfako2008@yahoo.com; bolayf@lr.afro.who.int; DiclaroJW@state.gov FU Department of Defense's Global Emerging Infections System (GEIS) [C0436-11-N3, C0549-12-N3] FX We thank Maria Badra for her assistance with logistical support of all personnel and materials pertaining to this study, and El-Shaimaa Nour El-Din, Rania Kaldas, Emad Fawaz, and Mahmoud Abdel-Dayem for their help in processing, identifying, and testing sand fly specimens. We thank the U.S. Navy Entomology Center of Excellence (NECE) staff for their assistance with collecting sand flies. We are grateful to the support staff of the Liberian Institute for Biomedical Research (LIBR), Monrovia, Liberia, for assisting and executing this study. A special thanks to Graham White and Seth Irish for providing a critical review of this manuscript. The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, the Department of the Army, and the Department of Defense, nor the U.S. Government. This work was funded by the Department of Defense's Global Emerging Infections System (GEIS) unit work numbers C0436-11-N3 and C0549-12-N3. This work was prepared as part of our official duties. Title 17 U.S.C. 105 provides that "Copyright protection under this title is not available for any work of the United States Government." Title 17 U.S.C. 101 defines a U.S. Government work as a work prepared by a military service member or employee of the U.S. Government as part of that person's official duties. Furthermore, this research was performed under a Memorandum of Understanding between the Walter Reed Army Institute of Research and the Smithsonian Institution, with institutional support provided by both organizations. NR 22 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-2585 EI 1938-2928 J9 J MED ENTOMOL JI J. Med. Entomol. PD MAY PY 2016 VL 53 IS 3 BP 717 EP 720 DI 10.1093/jme/tjv255 PG 4 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA DM6II UT WOS:000376454800036 PM 26810730 ER PT J AU Davis, FC Neta, M Kim, MJ Moran, JM Whalen, PJ AF Davis, F. Caroline Neta, Maital Kim, M. Justin Moran, Joseph M. Whalen, Paul J. TI Interpreting ambiguous social cues in unpredictable contexts SO SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE LA English DT Article DE amygdala; emotion; facial expression; Unpredictability ID HUMAN AMYGDALA RESPONSES; FACIAL EXPRESSIONS; TEMPORAL UNPREDICTABILITY; INDIVIDUAL-DIFFERENCES; SURPRISED FACES; STATE ANXIETY; FEAR; FMRI; ACTIVATION; PICTURES AB Unpredictable environments can be anxiety-provoking and elicit exaggerated emotional responses to aversive stimuli. Even neutral stimuli, when presented in an unpredictable fashion, prime anxiety-like behavior and elicit heightened amygdala activity. The amygdala plays a key role in initiating responses to biologically relevant information, such as facial expressions of emotion. While some expressions clearly signal negative (anger) or positive (happy) events, other expressions (e.g. surprise) are more ambiguous in that they can predict either valence, depending on the context. Here, we sought to determine whether unpredictable presentations of ambiguous facial expressions would bias participants to interpret them more negatively. We used functional magnetic resonance imaging and facial electromyography (EMG) to characterize responses to predictable vs unpredictable presentations of surprised faces. We observed moderate but sustained increases in amygdala reactivity to predictable presentations of surprised faces, and relatively increased amygdala responses to unpredictable faces that then habituated, similar to previously observed responses to clearly negative (e.g. fearful) faces. We also observed decreased corrugator EMG responses to predictable surprised face presentations, similar to happy faces, and increased responses to unpredictable surprised face presentations, similar to angry faces. Taken together, these data suggest that unpredictability biases people to interpret ambiguous social cues negatively. C1 [Davis, F. Caroline; Moran, Joseph M.] US Army, NSRDEC, Cognit Sci, Natick, MA USA. [Neta, Maital] Univ Nebraska, Ctr Brain Biol & Behav, Lincoln, NE USA. [Kim, M. Justin; Whalen, Paul J.] Dartmouth Coll, Dept Psychol & Brain Sci, Hanover, NH 03755 USA. [Moran, Joseph M.] Harvard Univ, Dept Psychol, 33 Kirkland St, Cambridge, MA 02138 USA. RP Davis, FC (reprint author), NSRDEC, 10 Kansas St, Natick, MA 01760 USA. EM f.c.davis4.civ@mail.mil FU National Institutes of Mental Health of the National Institutes of Health [P50MH069315, R01MH080716, F31MH090672] FX This research was supported by the National Institutes of Mental Health of the National Institutes of Health under award numbers P50MH069315, R01MH080716 and F31MH090672. The content of the reported research is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. NR 52 TC 1 Z9 1 U1 10 U2 11 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1749-5016 EI 1749-5024 J9 SOC COGN AFFECT NEUR JI Soc. Cogn. Affect. Neurosci. PD MAY PY 2016 VL 11 IS 5 BP 775 EP 782 DI 10.1093/scan/nsw003 PG 8 WC Neurosciences; Psychology; Psychology, Experimental SC Neurosciences & Neurology; Psychology GA DM9AH UT WOS:000376655100009 PM 26926605 ER PT J AU Brown, CJ Ward, J Mirecki, J AF Brown, Christopher J. Ward, James Mirecki, June TI A Revised Brackish Water Aquifer Storage and Recovery (ASR) Site Selection Index for Water Resources Management SO WATER RESOURCES MANAGEMENT LA English DT Article DE ASR; Performance factors; Recovery efficiency; Brackish water; Site selection; Dimensionless numbers; Upper Floridan Aquifer ID SALINE AQUIFERS; FRESH-WATER; OPERATION; QUALITY AB The performance of a brackish water aquifer storage and recovery (ASR) system is controlled by complex interactions among many variables. Some of these variables can be combined into dimensionless parameters to investigate the physical behavior and performance of an ASR well. Previous research has demonstrated that six dimensionless numbers are most useful for prediction of general performance of planned ASR projects. This paper first summarizes the critical literature and outlines the six dimensionless parameters and their various variable components. Then the new index is developed using the three best parameters. The three dimensionless parameters (RI, R-ASR and D) are normalized, scaled from 0 to 1, and combined through averaging to create a revised "Brackish Water ASR Site Selection Index" or I-ASR. The newly revised index builds upon previous work but also adds new variables important to site selection planning. In order to provide further validity to the index, it is validated against 29 ASR projects in Florida, USA. Finally, the use of the index is demonstrated for the Upper Floridan Aquifer in South Florida, USA. The demonstrated use of the new index illustrates how it can be useful for future ASR planning. C1 [Brown, Christopher J.] Univ N Florida, Sch Engn, Bldg 50,Room 2100, Jacksonville, FL 32224 USA. [Ward, James] Univ S Australia, SA Water Ctr Water Management & Reuse, GPO Box 2471, Adelaide, SA 5001, Australia. [Mirecki, June] US Army, Corps Engineers, Geotech Branch, 701 San Marco Blvd, Jacksonville, FL 32207 USA. RP Brown, CJ (reprint author), Univ N Florida, Sch Engn, Bldg 50,Room 2100, Jacksonville, FL 32224 USA. EM christopher.j.brown@unf.edu; James.Ward@unisa.edu.au; June.E.Mirecki@usace.army.mil NR 47 TC 0 Z9 0 U1 4 U2 5 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0920-4741 EI 1573-1650 J9 WATER RESOUR MANAG JI Water Resour. Manag. PD MAY PY 2016 VL 30 IS 7 BP 2465 EP 2481 DI 10.1007/s11269-016-1297-7 PG 17 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA DK0HO UT WOS:000374593700022 ER PT J AU Goetz, AE Pascual, LMM Dunford, DG Ogawa, KA Knorr, DB Boydston, AJ AF Goetz, Adam E. Pascual, Laura M. M. Dunford, Damian G. Ogawa, Kelli A. Knorr, Daniel B., Jr. Boydston, Andrew J. TI Expanded Functionality of Polymers Prepared Using Metal-Free Ring-Opening Metathesis Polymerization SO ACS MACRO LETTERS LA English DT Article ID LIVING RADICAL POLYMERIZATION; LIGHT PHOTOREDOX CATALYSIS; VISIBLE-LIGHT; ELECTRON-TRANSFER; ENOL ETHERS; TETRAHYDROFURAN; POLARITY AB Photoredox-mediated metal-free ring-opening metathesis polymerization (MF-ROMP) is an alternative to traditional metal-mediated ROMP that avoids the use of transition metal initiators while also enabling temporal control over the polymerization. Herein, we explore the effect of various additives on the success of the polymerization in order to optimize reaction protocols and identify new functionalized monomers that can be utilized in MF-ROMP. The use of protected alcohol monomers allows for homo- and copolymers to be prepared that contain functionality beyond simple alkyl groups. Several other functional groups are also tolerated to varying degrees and offer insight into future directions for expansion of monomer scope. C1 [Goetz, Adam E.; Pascual, Laura M. M.; Dunford, Damian G.; Ogawa, Kelli A.; Boydston, Andrew J.] Univ Washington, Dept Chem, Seattle, WA 98195 USA. [Knorr, Daniel B., Jr.] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Boydston, AJ (reprint author), Univ Washington, Dept Chem, Seattle, WA 98195 USA. EM ajb1515@uw.edu FU Army Research Office [W911NF-15-1-0139]; Washington Research Foundation; Department of Defense; Army Research Office FX We gratefully acknowledge financial support from the Army Research Office (Grant No. W911NF-15-1-0139) and the Washington Research Foundation. LMMP thanks the Department of Defense and Army Research Office for a National Defense Science and Engineering Graduate Fellowship. NR 29 TC 2 Z9 2 U1 9 U2 22 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 2161-1653 J9 ACS MACRO LETT JI ACS Macro Lett. PD MAY PY 2016 VL 5 IS 5 BP 579 EP 582 DI 10.1021/acsmacrolett.6b00131 PG 4 WC Polymer Science SC Polymer Science GA DM3DA UT WOS:000376225800006 ER PT J AU Horton, JM Wiles, GC Lawson, DE Appleton, SN Wilch, J Wiesenberg, N AF Horton, Jennifer M. Wiles, Gregory C. Lawson, Daniel E. Appleton, Sarah N. Wilch, Joseph Wiesenberg, Nicholas TI Tree ring-dated glacial history for the first millennium CE, Casement Glacier and Adams Inlet, Glacier Bay, Alaska, USA SO ARCTIC ANTARCTIC AND ALPINE RESEARCH LA English DT Article ID SOUTHEAST ALASKA; TEMPERATURE VARIABILITY; NATIONAL-PARK; MUIR INLET; FLUCTUATIONS; AGE; ADVANCE; AD; PRESERVE; UPLIFT AB Calendar dating of tree-ring series from 16 logs sampled near the margin of Casement Glacier combined with tree-ring dates on 36 detrital logs from Adams Inlet, Glacier Bay National Park and Preserve, Alaska, show killing of trees by ice and lake sediments from the mid-sixth through mid-seventh centuries C.E. The dates from the land-terminating Casement Glacier show ice advance into a forest between 560 and 570 C.E. within a few kilometers of the 2011 retreating margin.Advance of the tidewater glacier in Muir Inlet blocked offAdams Inlet forming Lake Adams between 540 and 640 C.E. This glacier and lake history for Glacier Bay is consistent with other land-terminating ice expansions across the Gulf of Alaska that similarly show advance centered on 600 C.E., as well as other proxy records from lakes all suggesting cooling during this interval. The cooling closely follows a series of eruptions in the mid to late sixth century, which may have contributed to the cooling. Radiocarbon ages in Adams Inlet suggest that Lake Adams persisted through 880 cal. yr C.E. and drained by 1170 cal. yr C.E. Ice retreat and this lake drainage are broadly coincident with Medieval warming recognized along the Gulf of Alaska in dendroclimatic reconstructions. Shortly after this retreat, Little Ice Age readvance occurred with Casement Glacier coalescing with glaciers in Adams Inlet and the West Arm, subsequently filling all of Glacier Bay to its Holocene maximum by 1750 C.E. C1 [Horton, Jennifer M.; Wiles, Gregory C.; Appleton, Sarah N.; Wilch, Joseph; Wiesenberg, Nicholas] Coll Wooster, Dept Geol, 1189 Beall Ave, Wooster, OH 44691 USA. [Lawson, Daniel E.] CRREL, 72 Lyme Rd, Hanover, NH 03755 USA. [Lawson, Daniel E.] Dartmouth Coll, 72 Lyme Rd, Hanover, NH 03755 USA. RP Wiles, GC (reprint author), Coll Wooster, Dept Geol, 1189 Beall Ave, Wooster, OH 44691 USA. EM gwiles@wooster.edu FU National Science Foundation [ATM-0902799, AGS-1502186] FX This work was supported by the National Science Foundation under grants ATM-0902799, ATM-0902799, and AGS-1502186. We appreciate the logistical support provided by the National Park Service at Glacier Bay National Park and Preserve and its ongoing collaboration in curating the Glacier Bay collection of interstadial wood. We would also like to thank three anonymous reviewers for their careful critique and advice. NR 40 TC 0 Z9 0 U1 5 U2 5 PU INST ARCTIC ALPINE RES PI BOULDER PA UNIV COLORADO, BOULDER, CO 80309 USA SN 1523-0430 EI 1938-4246 J9 ARCT ANTARCT ALP RES JI Arct. Antarct. Alp. Res. PD MAY PY 2016 VL 48 IS 2 BP 253 EP 261 DI 10.1657/AAAR0015-038 PG 9 WC Environmental Sciences; Geography, Physical SC Environmental Sciences & Ecology; Physical Geography GA DM3DJ UT WOS:000376226700003 ER PT J AU Tati, S Rager, S Ko, BJ Cao, GH Swami, A La Porta, T AF Tati, Srikar Rager, Scott Ko, Bong Jun Cao, Guohong Swami, Ananthram La Porta, Thomas TI netCSI: A Generic Fault Diagnosis Algorithm for Large-Scale Failures in Computer Networks SO IEEE TRANSACTIONS ON DEPENDABLE AND SECURE COMPUTING LA English DT Article DE Fault diagnosis; large-scale network failures; incomplete information; clustered failures ID TOMOGRAPHY AB We present a framework and a set of algorithms for determining faults in networks when large scale outages occur. The design principles of our algorithm, netCSI, are motivated by the fact that failures are geographically clustered in such cases. We address the challenge of determining faults with incomplete symptom information due to a limited number of reporting nodes. netCSI consists of two parts: a hypotheses generation algorithm, and a ranking algorithm. When constructing the hypothesis list of potential causes, we make novel use of positive and negative symptoms to improve the precision of the results. In addition, we propose pruning and thresholding along with a dynamic threshold value selector, to reduce the complexity of our algorithm. The ranking algorithm is based on conditional failure probability models that account for the geographic correlation of the network objects in clustered failures. We evaluate the performance of netCSI for networks with both random and realistic topologies. We compare the performance of netCSI with an existing fault diagnosis algorithm, MAX-COVERAGE, and demonstrate an average gain of 128 percent in accuracy for realistic topologies. C1 [Tati, Srikar; Rager, Scott; Cao, Guohong; La Porta, Thomas] Penn State Univ, University Pk, PA 16802 USA. [Ko, Bong Jun] IBM TJ Watson Res Ctr, Cambridge, MA USA. [Swami, Ananthram] Army Res Lab, Adelphi, MD 20783 USA. RP Tati, S; Rager, S; Cao, GH; La Porta, T (reprint author), Penn State Univ, University Pk, PA 16802 USA.; Ko, BJ (reprint author), IBM TJ Watson Res Ctr, Cambridge, MA USA.; Swami, A (reprint author), Army Res Lab, Adelphi, MD 20783 USA. EM tati@cse.psu.edu; str5004@cse.psu.edu; bongjun_ko@us.ibm.com; gcao@cse.psu.edu; aswami@arl.army.mil; tlp@cse.psu.edu FU US Army Research Laboratory; U.K. Ministry of Defence [W911NF-06-3-0001]; Defense Threat Reduction Agency (DTRA) FX This research was sponsored by the US Army Research Laboratory and the U.K. Ministry of Defence and was accomplished under Agreement Number W911NF-06-3-0001. The views and conclusions contained in this document are those of the author(s) and should not be interpreted as representing the official policies, either expressed or implied, of the US Army Research Laboratory, the US Government, the U.K. Ministry of Defense or the U.K. Government. The US and U.K. Governments are authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation hereon. In addition to ITA, this research had been sponsored by Defense Threat Reduction Agency (DTRA). NR 25 TC 0 Z9 0 U1 1 U2 1 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 1545-5971 EI 1941-0018 J9 IEEE T DEPEND SECURE JI IEEE Trans. Dependable Secur. Comput. PD MAY-JUN PY 2016 VL 13 IS 3 BP 355 EP 368 DI 10.1109/TDSC.2014.2369051 PG 14 WC Computer Science, Hardware & Architecture; Computer Science, Information Systems; Computer Science, Software Engineering SC Computer Science GA DM1EL UT WOS:000376088100004 ER PT J AU Kotwal, RS Champion, HR Gross, KR AF Kotwal, Russ S. Champion, Howard R. Gross, Kirby R. TI A Military-Specific Injury Scoring System to Aid in Understanding the Golden Hour Reply SO JAMA SURGERY LA English DT Letter ID COMBAT INJURY C1 [Kotwal, Russ S.; Gross, Kirby R.] Joint Base San Antonio Ft Sam Houston, US Army Inst Surg Res, Joint Trauma Syst, Trauma Care Delivery, Ft Sam Houston, TX 78234 USA. [Kotwal, Russ S.; Champion, Howard R.; Gross, Kirby R.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Kotwal, Russ S.] Texas A&M Hlth Sci Ctr, Coll Med, College Stn, TX USA. RP Kotwal, RS (reprint author), Joint Base San Antonio Ft Sam Houston, US Army Inst Surg Res, Joint Trauma Syst, Trauma Care Delivery, Ft Sam Houston, TX 78234 USA. EM russ.kotwal@us.army.mil NR 4 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6254 EI 2168-6262 J9 JAMA SURG JI JAMA Surg. PD MAY PY 2016 VL 151 IS 5 BP 491 EP 492 DI 10.1001/jamasurg.2015.4895 PG 5 WC Surgery SC Surgery GA DM0CY UT WOS:000376011600030 PM 26763674 ER PT J AU Hanson, JA Lin, YH Dretsch, MN Strandjord, SE Haub, MD Hibbeln, JR AF Hanson, Jennifer A. Lin, Yu-Hong Dretsch, Michael N. Strandjord, Sarah E. Haub, Mark D. Hibbeln, Joseph R. TI Whole food, functional food, and supplement sources of omega-3 fatty acids and omega-3 HUFA scores among US soldiers SO JOURNAL OF FUNCTIONAL FOODS LA English DT Article DE Omega-3 fatty acids; Functional food; Food frequency questionnaire; Docosahexaenoic acid; Eicosapentaenoic acid; Military personnel ID POLYUNSATURATED FATTY-ACIDS; CORONARY-HEART-DISEASE; BODY-MASS INDEX; FREQUENCY QUESTIONNAIRE; FISH CONSUMPTION; DEPRESSIVE SYMPTOMS; COGNITIVE DECLINE; N-3; VALIDATION; ADULTS AB A questionnaire to measure consumption of contemporary sources of omega-3 fatty acids including (i) seafood, (ii) poultry and eggs, (iii) omega-3 functional foods, and (iv) dietary supplements was completed by U.S. soldiers (N = 191). Omega-3 highly unsaturated fatty acid (HUFA) scores were higher (p < 0.01) among those who (i) took an omega-3 supplement, (ii) consumed sushi, (iii) consumed omega-3 functional foods, (iv) consumed beef less than twice per week, and (v) ate seafood at least twice a week. Omega-3 HUFA was positively correlated with EPA + DHA intake (beta = 0.39; p < 0.01) and age (beta = 0.14; p = 0.03) and negatively correlated with beef intake (beta = -0.13; p = 0.05) and smoking (beta = -0.12; p = 0.08). Intake of contemporary foods rich in omega-3s were associated with higher biomarker values while smoking and beef intake were associated with lower values. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Hanson, Jennifer A.; Haub, Mark D.] Kansas State Univ, Dept Food Nutr Dietet & Hlth, 212 Justin Hall, Manhattan, KS 66506 USA. [Lin, Yu-Hong; Strandjord, Sarah E.; Hibbeln, Joseph R.] NIAAA, Sect Nutr Neurosci, Lab Membrane Biochem & Biophys, NIH, 5625 Fishers Lane,Rm 3N-07,MSC 9410, Bethesda, MD 20892 USA. [Dretsch, Michael N.] US Army Aeromed Res Lab, Ft Rucker, AL USA. [Dretsch, Michael N.] HQ TRADOC, Cognit Dominance Team, Human Dimens Div, Capabil Dev Directorate, Ft Eustis, VA 23604 USA. [Strandjord, Sarah E.] Case Western Reserve Univ, Cleveland Clin, Lerner Coll Med, 9500 Euclid Ave NA21, Cleveland, OH USA. RP Hanson, JA (reprint author), Kansas State Univ, Dept Food Nutr Dietet & Hlth, 212 Justin Hall, Manhattan, KS 66506 USA. EM jhanson2@ksu.edu OI Hanson, Jennifer /0000-0003-0437-6489 FU Academy of Nutrition and Dietetics Foundation; Intramural Research Program of the National Institute on Alcohol Abuse and Alcoholism, NIH; Kansas State University Research Foundation Fellowship Award FX This project was partially funded by the Herbert D. and Nylda Gemple Research Award from the Academy of Nutrition and Dietetics Foundation, the Intramural Research Program of the National Institute on Alcohol Abuse and Alcoholism, NIH and the Kansas State University Research Foundation Fellowship Award. NR 46 TC 0 Z9 0 U1 9 U2 19 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1756-4646 J9 J FUNCT FOODS JI J. Funct. Food. PD MAY PY 2016 VL 23 BP 167 EP 176 DI 10.1016/j.jff.2016.02.017 PG 10 WC Food Science & Technology SC Food Science & Technology GA DM1ZK UT WOS:000376145200016 ER PT J AU Kilianski, A Nuzzo, JB Modjarrad, K AF Kilianski, Andy Nuzzo, Jennifer B. Modjarrad, Kayvon TI Gain-of-Function Research and the Relevance to Clinical Practice SO JOURNAL OF INFECTIOUS DISEASES LA English DT Review DE gain of function; potential pandemic pathogens; coronavirus; influenza; science policy; health policy ID EBOLA-VIRUS; MOUSE MODEL; DISEASE; TRANSMISSION; INHIBITORS; FERRETS; RISKS; MICE; H7N9 AB The ongoing moratorium on gain-of-function (GOF) research with highly pathogenic avian influenza virus, severe acute respiratory syndrome coronavirus, and Middle East respiratory syndrome coronavirus has drawn attention to the current debate on these research practices and the potential benefits and risks they present. While much of the discussion has been steered by members of the microbiology and policy communities, additional input from medical practitioners will be highly valuable toward developing a broadly inclusive policy that considers the relative value and harm of GOF research. This review attempts to serve as a primer on the topic for the clinical community by providing a historical context for GOF research, summarizing concerns about its risks, and surveying the medical products that it has yielded. C1 [Kilianski, Andy] Edgewood Chem Biol Ctr, BioSci Div, BioDefense Branch, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. [Nuzzo, Jennifer B.] Univ Pittsburgh, Med Ctr, Ctr Hlth Secur, Baltimore, MD USA. [Modjarrad, Kayvon] US Mil HIV Res Program, Walter Reed Army Inst Res, Silver Spring, MD USA. RP Kilianski, A (reprint author), Edgewood Chem Biol Ctr, BioSci Div, BioDefense Branch, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM andrew.kilianski.ctr@mail.mil FU National Academy of Sciences; DTRA (National Research Council) FX This work was supported by the National Academy of Sciences (to A. K.) and the DTRA (National Research Council fellowship to A. K.). NR 49 TC 5 Z9 5 U1 4 U2 6 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD MAY 1 PY 2016 VL 213 IS 9 BP 1364 EP 1369 DI 10.1093/infdis/jiv473 PG 6 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA DM4DM UT WOS:000376295800003 PM 26416657 ER PT J AU Wang, YC Wu, XM Chen, J Amin, R Lu, M Bhayana, B Zhao, J Murray, CK Hamblin, MR Hooper, DC Dai, TH AF Wang, Yucheng Wu, Ximing Chen, Jia Amin, Rehab Lu, Min Bhayana, Brijesh Zhao, Jie Murray, Clinton K. Hamblin, Michael R. Hooper, David C. Dai, Tianhong TI Antimicrobial Blue Light Inactivation of Gram-Negative Pathogens in Biofilms: In Vitro and In Vivo Studies SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE antimicrobial blue light; biofilm; Pseudomonas aeruginosa; Acinetobacter baumannii; endogenous porphyrins; burn wound; mouse model; bioluminescence imaging; HPLC; TUNEL assay ID ACINETOBACTER-BAUMANNII INFECTION; RESISTANT STAPHYLOCOCCUS-AUREUS; PSEUDOMONAS-AERUGINOSA BIOFILMS; WOUND INFECTIONS; PROPIONIBACTERIUM-ACNES; ANTIBIOTIC TOLERANCE; HELICOBACTER-PYLORI; OXYGEN LIMITATION; BACTERIA; MODEL AB Background. Biofilms affect >80% bacterial infections in human and are usually difficult to eradicate because of their inherent drug resistance. Methods. We investigated the effectiveness of antimicrobial blue light (aBL) (wavelength, 415 nm) for inactivatingAcinetobacter baumannii orPseudomonas aeruginosa biofilms in 96-well microplates or infected mouse burn wounds. Results. In vitro, in 96-well microplates, exposure of 24-hour-old and 72-hour-oldA. baumannii biofilms to 432 J/cm(2) aBL resulted in inactivation of 3.59 log(10) and 3.18 log(10) colony-forming units (CFU), respectively. ForP. aeruginosa biofilms, similar levels of inactivation-3.02 log(10) and 3.12 log(10) CFU, respectively-were achieved. In mouse burn wounds infected with 5 x 10(6) CFU ofA. baumannii, approximately 360 J/cm(2) and 540 J/cm(2) aBL was required to inactivate 3 log(10) CFU in biofilms when delivered 24 and 48 hours, respectively, after bacterial inoculation. High-performance liquid chromatography analysis revealed the presence of endogenous porphyrins in bothA. baumannii andP. aeruginosa. TUNEL assay detected no apoptotic cells in aBL-irradiated mouse skin at up to 24 hours after aBL exposure (540 J/cm(2)). Conclusions. aBL has antimicrobial activity in biofilms ofA. baumannii andP. aeruginosa and is a potential therapeutic approach for biofilm-related infections. C1 [Wang, Yucheng] Chinese Peoples Liberat Army Gen Hosp, Dept Laser Med, Beijing 100853, Peoples R China. [Wang, Yucheng] Nankai Univ, Coll Med, Tianjin 300071, Peoples R China. [Chen, Jia] Shanghai Dermatol Hosp, Shanghai, Peoples R China. [Wang, Yucheng; Wu, Ximing; Chen, Jia; Amin, Rehab; Lu, Min; Bhayana, Brijesh; Zhao, Jie; Hamblin, Michael R.; Dai, Tianhong] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Wellman Ctr Photomed, BAR 404B,55 Fruit St, Boston, MA 02114 USA. [Hooper, David C.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Div Infect Dis, BAR 404B,55 Fruit St, Boston, MA 02114 USA. [Hamblin, Michael R.] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA. [Murray, Clinton K.] Brooke Army Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. RP Dai, TH (reprint author), Harvard Univ, Massachusetts Gen Hosp, Sch Med, Wellman Ctr Photomed, BAR 404B,55 Fruit St, Boston, MA 02114 USA. EM tdai@mgh.harvard.edu FU Center for Integration of Medicine and Innovative Technology under US Army Medical Research Acquisition Activity [14-1894]; National Institutes of Health [1R21AI109172]; American Society for Laser Medicine and Surgery [BS.S02.15] FX This work was supported by the Center for Integration of Medicine and Innovative Technology, under a US Army Medical Research Acquisition Activity Cooperative Agreement (award 14-1894 to T. D.); the National Institutes of Health (1R21AI109172 to T. D.); and the American Society for Laser Medicine and Surgery (student research grant BS.S02.15 to Y. W.). NR 45 TC 4 Z9 4 U1 12 U2 15 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD MAY 1 PY 2016 VL 213 IS 9 BP 1380 EP 1387 DI 10.1093/infdis/jiw070 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA DM4DM UT WOS:000376295800005 PM 26908743 ER PT J AU Clapham, HE Rodriguez-Barraquer, I Azman, AS Althouse, BM Salje, H Gibbons, RV Rothman, AL Jarman, RG Nisalak, A Thaisomboonsuk, B Kalayanarooj, S Nimmannitya, S Vaughn, DW Green, S Yoon, IK Cummings, DAT AF Clapham, Hannah E. Rodriguez-Barraquer, Isabel Azman, Andrew S. Althouse, Benjamin M. Salje, Henrik Gibbons, Robert V. Rothman, Alan L. Jarman, Richard G. Nisalak, Ananda Thaisomboonsuk, Butsaya Kalayanarooj, Siripen Nimmannitya, Suchitra Vaughn, David W. Green, Sharone Yoon, In-Kyu Cummings, Derek A. T. TI Dengue Virus (DENV) Neutralizing Antibody Kinetics in Children After Symptomatic Primary and Postprimary DENV Infection SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE dengue; neutralizing antibody; longitudinal antibody kinetics; vaccine ID TIME-INTERVAL; DISEASE; THAILAND; TRANSMISSION; PROTECTION; SEVERITY; ILLNESS; BURDEN; COHORT AB The immune response to dengue virus (DENV) infection is complex and not fully understood. Using longitudinal data from 181 children with dengue in Thailand who were followed for up to 3 years, we describe neutralizing antibody kinetics following symptomatic DENV infection. We observed that antibody titers varied by serotype, homotypic vs heterotypic responses, and primary versus postprimary infections. The rates of change in antibody titers over time varied between primary and postprimary responses. For primary infections, titers increased from convalescence to 6 months. By comparing homotypic and heterotypic antibody titers, we saw an increase in type specificity from convalescence to 6 months for primary DENV3 infections but not primary DENV1 infections. In postprimary cases, there was a decrease in titers from convalescence up until 6 months after infection. Beginning 1 year after both primary and postprimary infections, there was evidence of increasing antibody titers, with greater increases in children with lower titers, suggesting that antibody titers were boosted due to infection and that higher levels of neutralizing antibody may be more likely to confer a sterilizing immune response. These findings may help to model virus transmission dynamics and provide baseline data to support the development of vaccines and therapeutics. C1 [Clapham, Hannah E.; Rodriguez-Barraquer, Isabel; Azman, Andrew S.; Salje, Henrik; Cummings, Derek A. T.] Johns Hopkins Univ Bloomberg Sch Publ Hlth, Dept Epidemiol, 615 N Wolfe St, Baltimore, MD 21224 USA. [Althouse, Benjamin M.] Inst Dis Modeling, Bellevue, WA USA. [Althouse, Benjamin M.] Santa Fe Inst, Las Cruces, NM USA. [Althouse, Benjamin M.] New Mexico State Univ, Las Cruces, NM 88003 USA. [Gibbons, Robert V.] US Army, Inst Surg Res, San Antonio, TX USA. [Rothman, Alan L.] Univ Rhode Isl, 825 Chalkstone Ave, Providence, RI 02908 USA. [Cummings, Derek A. T.] Univ Florida, Dept Biol, Gainesville, FL USA. [Cummings, Derek A. T.] Univ Florida, Emerging Pathogens Inst, Gainesville, FL USA. [Green, Sharone] Univ Massachusetts, Sch Med, Div Infect Dis & Immunol, Worcester, MA USA. [Jarman, Richard G.; Nisalak, Ananda; Thaisomboonsuk, Butsaya; Vaughn, David W.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Kalayanarooj, Siripen; Nimmannitya, Suchitra] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand. [Clapham, Hannah E.; Yoon, In-Kyu] Int Vaccine Inst, Dengue Vaccine Initiat, Seoul, South Korea. RP Clapham, HE (reprint author), Johns Hopkins Univ Bloomberg Sch Publ Hlth, 615 N Wolfe St, Baltimore, MD 21224 USA. EM hannah.e.clapham@gmail.com OI Azman, Andrew/0000-0001-8662-9077; Salje, Henrik/0000-0003-3626-4254 FU National Institutes of Health [P01 AI034533, R01 AI102939]; US Army Medical Research and Materiel Command FX This work was supported by the National Institutes of Health (grant P01 AI034533; grant R01 AI102939 to D. A. T. C.) and the US Army Medical Research and Materiel Command. NR 24 TC 1 Z9 1 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD MAY 1 PY 2016 VL 213 IS 9 BP 1428 EP 1435 DI 10.1093/infdis/jiv759 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA DM4DM UT WOS:000376295800010 PM 26704615 ER PT J AU Lin, JT Ubalee, R Lon, C Balasubramanian, S Kuntawunginn, W Rahman, R Saingam, P Heng, TK Vy, D San, S Nuom, S Burkly, H Chanarat, N Ponsa, C Levitz, L Parobek, C Chuor, CM Somethy, S Spring, M Lanteri, C Gosi, P Meshnick, SR Saunders, DL AF Lin, Jessica T. Ubalee, Ratawan Lon, Chanthap Balasubramanian, Sujata Kuntawunginn, Worachet Rahman, Rifat Saingam, Piyaporn Thay Kheang Heng Dav Vy San, Savoeun Nuom, Sarath Burkly, Hana Chanarat, Nitima Ponsa, Chanudom Levitz, Lauren Parobek, Christian Chuor, Char Meng Somethy, Sok Spring, Michele Lanteri, Charlotte Gosi, Panita Meshnick, Steven R. Saunders, David L. TI Microscopic Plasmodium falciparum Gametocytemia and Infectivity to Mosquitoes in Cambodia SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE gametocyte; membrane feeding; infectious reservoir; malaria transmission; Plasmodium falciparum; submicroscopic; Anopheles dirus ID MALARIA INFECTIONS; TRANSMISSION; RELEVANCE AB Although gametocytes are essential for malaria transmission, in Africa many falciparum-infected persons without smear-detectable gametocytes still infect mosquitoes. To see whether the same is true in Southeast Asia, we determined the infectiousness of 119 falciparum-infected Cambodian adults to Anopheles dirus mosquitoes by membrane feeding. Just 5.9% of subjects infected mosquitoes. The 8.4% of patients with smear-detectable gametocytes were >20 times more likely to infect mosquitoes than those without and were the source of 96% of all mosquito infections. In low-transmission settings, targeting transmission-blocking interventions to those with microscopic gametocytemia may have an outsized effect on malaria control and elimination. C1 [Lin, Jessica T.; Balasubramanian, Sujata; Rahman, Rifat] Univ N Carolina, Sch Med, Div Infect Dis, 130 Mason Farm Rd,Ste 2115,CB 7030, Chapel Hill, NC 27599 USA. [Levitz, Lauren; Meshnick, Steven R.] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, 130 Mason Farm Rd,Ste 2115,CB 7030, Chapel Hill, NC 27599 USA. [Parobek, Christian] Univ N Carolina, Curriculum Genet & Mol Biol, 130 Mason Farm Rd,Ste 2115,CB 7030, Chapel Hill, NC 27599 USA. [Ubalee, Ratawan; Ponsa, Chanudom] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Kuntawunginn, Worachet; Saingam, Piyaporn; Burkly, Hana; Chanarat, Nitima; Spring, Michele; Lanteri, Charlotte; Gosi, Panita; Saunders, David L.] Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand. [Lon, Chanthap; Nuom, Sarath] Armed Forces Res Inst Med Sci, Phnom Penh, Cambodia. [Thay Kheang Heng; Chuor, Char Meng] Natl Malaria Ctr, Phnom Penh, Cambodia. [Dav Vy; Somethy, Sok] Royal Cambodian Armed Forces, Phnom Penh, Cambodia. [San, Savoeun] Battambang Referral Hosp, Battambang, Cambodia. RP Lin, JT (reprint author), Univ N Carolina, Div Infect Dis, 130 Mason Farm Rd,Ste 2115,CB 7030, Chapel Hill, NC 27599 USA. EM jessica_lin@med.unc.edu FU Armed Forces Health Surveillance Center/Global Emerging Infections Surveillance and Response System; Military Infectious Disease Research Program; National Institute of Allergy and Infectious Diseases [K08 AI110651]; American Society of Tropical Medicine and Hygiene; Burroughs Wellcome Fund FX This work was supported by the Armed Forces Health Surveillance Center/Global Emerging Infections Surveillance and Response System, Military Infectious Disease Research Program, National Institute of Allergy and Infectious Diseases (K08 AI110651 to J. T. L.), American Society of Tropical Medicine and Hygiene (postdoctoral fellowship in tropical infectious diseases to J. T. L. and Benjamin Kean travel fellowship to Christian Parobek), and Burroughs Wellcome Fund (aforementioned fellowship to J. T. L.). NR 15 TC 3 Z9 3 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD MAY 1 PY 2016 VL 213 IS 9 BP 1491 EP 1494 DI 10.1093/infdis/jiv599 PG 4 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA DM4DM UT WOS:000376295800019 PM 26667316 ER PT J AU Lin, JT Meshnick, SR Saunders, DL Lon, C AF Lin, Jessica T. Meshnick, Steven R. Saunders, David L. Lon, Chanthap TI Infectivity of Microscopic and Submicroscopic Malaria Parasite Infections in Areas of Low Malaria Endemicity Reply SO JOURNAL OF INFECTIOUS DISEASES LA English DT Letter ID RESERVOIR; THAILAND C1 [Lin, Jessica T.] Univ N Carolina, Sch Med, Div Infect Dis, 130 Mason Farm Rd,Ste 2115,CB 7030, Chapel Hill, NC 27599 USA. [Meshnick, Steven R.] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, 130 Mason Farm Rd,Ste 2115,CB 7030, Chapel Hill, NC 27599 USA. [Saunders, David L.] Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand. [Lon, Chanthap] Armed Forces Res Inst Med Sci, Phnom Penh, Cambodia. RP Lin, JT (reprint author), Univ N Carolina, Div Infect Dis, 130 Mason Farm Rd,Ste 2115,CB 7030, Chapel Hill, NC 27599 USA. EM jessica_lin@med.unc.edu FU NIAID NIH HHS [K08 AI110651] NR 5 TC 0 Z9 0 U1 1 U2 1 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD MAY 1 PY 2016 VL 213 IS 9 BP 1517 EP 1517 DI 10.1093/infdis/jiw045 PG 1 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA DM4DM UT WOS:000376295800023 PM 26908729 ER PT J AU Ensley, TR Hu, HH Reichert, M Ferdinandus, MR Peceli, D Hales, JM Perry, JW Li, ZA Jang, SH Jen, AKY Marder, SR Hagan, DJ Van Stryland, EW AF Ensley, Trenton R. Hu, Honghua Reichert, Matthew Ferdinandus, Manuel R. Peceli, Davorin Hales, Joel M. Perry, Joseph W. Li, Zhong'an Jang, Sei-hum Jen, Alex K. -Y. Marder, Seth R. Hagan, David J. Van Stryland, Eric W. TI Quasi-three-level model applied to measured spectra of nonlinear absorption and refraction in organic molecules (vol 33, pg 780, 2016) SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICS LA English DT Correction C1 [Ensley, Trenton R.; Hu, Honghua; Reichert, Matthew; Ferdinandus, Manuel R.; Peceli, Davorin; Hagan, David J.; Van Stryland, Eric W.] Univ Cent Florida, Coll Opt & Photon, CREOL, Orlando, FL 32816 USA. [Ensley, Trenton R.] US Army, Res Lab, Adelphi, MD 20783 USA. [Ferdinandus, Manuel R.] Air Force Inst Technol, Dept Engn Phys, Dayton, OH 45433 USA. [Hales, Joel M.; Perry, Joseph W.; Marder, Seth R.] Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA. [Perry, Joseph W.; Li, Zhong'an; Marder, Seth R.] Georgia Inst Technol, Ctr Organ Photon & Elect, Atlanta, GA 30332 USA. [Li, Zhong'an; Jang, Sei-hum; Jen, Alex K. -Y.] Univ Washington, Dept Mat Sci & Engn, Seattle, WA 98195 USA. [Hagan, David J.; Van Stryland, Eric W.] Univ Cent Florida, Dept Phys, Orlando, FL 32816 USA. RP Van Stryland, EW (reprint author), Univ Cent Florida, Coll Opt & Photon, CREOL, Orlando, FL 32816 USA.; Van Stryland, EW (reprint author), Univ Cent Florida, Dept Phys, Orlando, FL 32816 USA. EM ewvs@creol.ucf.edu RI Hagan, David/H-2204-2011; Reichert, Matthew/N-1191-2015 OI Hagan, David/0000-0003-2713-1767; Reichert, Matthew/0000-0003-1701-9376 NR 1 TC 0 Z9 0 U1 2 U2 4 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0740-3224 EI 1520-8540 J9 J OPT SOC AM B JI J. Opt. Soc. Am. B-Opt. Phys. PD MAY 1 PY 2016 VL 33 IS 5 BP 1007 EP 1007 DI 10.1364/JOSAB.33.001007 PG 1 WC Optics SC Optics GA DM3JR UT WOS:000376243200026 ER PT J AU Tassev, VL Vangala, SR Peterson, RD Kimani, MM Snure, M Stites, RW Guha, S Slagle, JE Ensley, TR Syed, AA Markov, IV AF Tassev, Vladimir L. Vangala, Shivashankar R. Peterson, Rita D. Kimani, Martin M. Snure, Michael Stites, Ronald W. Guha, Shekhar Slagle, Jonathan E. Ensley, Trenton R. Syed, Akbar A. Markov, Ivan V. TI Heteroepitaxial growth of OPGaP on OPGaAs for frequency conversion in the IR and THz SO OPTICAL MATERIALS EXPRESS LA English DT Article ID GAP; GAAS; SUPERLATTICES; ABSORPTION; FILMS AB For the first time thick orientation-patterned GaP (OPGaP) was repeatedly grown heteroepitaxially on OPGaAs templates as a quasi-phase matched medium for frequency conversion in the mid and longwave IR, and THz regions. The OP templates were fabricated by wafer-bonding and in a MBE-assisted polarity inversion process. Standard low-pressure hydride vapor phase epitaxy (LP-HVPE) was used for one-step growth of up to 400 mu m thick device quality OPGaP with excellent domain fidelity. The presented results can be viewed as the missing link between a well-developed technique for preparation of OP templates, using one robust nonlinear optical material (GaAs), and the subsequent thick epitaxial growth on them of another material (GaP). The reason for these efforts is that the second material has some indisputable advantages in point of view of thermal and optical properties but the preparation of native templates encounters challenges, which makes it difficult to obtain high quality homoepitaxial growth at an affordable price. Successful heteroepitaxial growth at such a relatively high lattice mismatch (- 3.6%) in a close to equilibrium growth process such as HVPE is noteworthy, especially when previously reported attempts, for example, growth of OPZnSe on OPGaAs templates at about 10 times smaller lattice mismatch (+ 0.3%) have produced only limited results. Combining the advantages of the two most promising nonlinear materials, GaAs and GaP, is a solution that will accelerate the development of high power, tunable laser sources for the IR and THz region, which are in great demand on the market. (C) 2016 Optical Society of America. C1 [Tassev, Vladimir L.; Vangala, Shivashankar R.; Peterson, Rita D.; Kimani, Martin M.; Snure, Michael; Stites, Ronald W.; Guha, Shekhar; Slagle, Jonathan E.] US Air Force, Res Lab, Wright Patterson AFB, OH 45433 USA. [Vangala, Shivashankar R.] SURVICE Eng Co, Dayton, OH 45431 USA. [Kimani, Martin M.] WYLE, Aerosp Grp, 909 W Inyokern Rd Suite C, Ridgecrest, CA 93555 USA. [Ensley, Trenton R.; Syed, Akbar A.] Univ Cent Florida, Coll Opt & Photon, CREOL, Orlando, FL 32816 USA. [Ensley, Trenton R.] US Army, Res Lab, Adelphi, MD 20783 USA. [Markov, Ivan V.] Bulgarian Acad Sci, Inst Phys Chem, Sofia, Bulgaria. RP Tassev, VL (reprint author), US Air Force, Res Lab, Wright Patterson AFB, OH 45433 USA. EM vladimir.tassev@wpafb.af.mil FU Air Force Office for Scientific Research [13RY09COR] FX This research was supported by the Air Force Office for Scientific Research under funding 13RY09COR. The authors are very thankful to Prof. Eric Van Stryland and Prof. David Hagan from UCF for the part of the optical measurements conducted at CREOL. NR 45 TC 0 Z9 0 U1 1 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 2159-3930 J9 OPT MATER EXPRESS JI Opt. Mater. Express PD MAY 1 PY 2016 VL 6 IS 5 BP 1724 EP 1737 DI 10.1364/OME.6.001724 PG 14 WC Materials Science, Multidisciplinary; Optics SC Materials Science; Optics GA DM3JF UT WOS:000376242000033 ER PT J AU Marcsisin, SR Reichard, G Pybus, BS AF Marcsisin, Sean R. Reichard, Gregory Pybus, Brandon S. TI Primaquine pharmacology in the context of CYP 2D6 pharmacogenomics: Current state of the art SO PHARMACOLOGY & THERAPEUTICS LA English DT Review DE Primaquine; CYP 2D6; 8-Aminoquinoline; Pharmacogenomics; Hepatic metabolism; Plasmodium vivax ID ANTIMALARIAL-DRUG PRIMAQUINE; PLASMODIUM-VIVAX MALARIA; INDUCED HEMOLYTIC-ANEMIA; ADULT THAI SUBJECTS; INFECTION IN-VITRO; CYTOCHROME-P450 2D6; PHARMACOKINETIC INTERACTIONS; PYRONARIDINE-ARTESUNATE; GENETIC POLYMORPHISMS; HUMAN-ERYTHROCYTES AB Primaquine is the only antimalarial drug available to clinicians for the treatment of relapsing forms of malaria. Primaquine development and usage dates back to the 1940s and has been administered to millions of individuals to treat and eliminate malaria infections. Primaquine therapy is not without disadvantages, however, as it can cause life threatening hemolysis in humans with glucose-6-phosphate dehydrogenase (G6PD) deficiency. In addition, the efficacy of primaquine against relapsing malaria was recently linked to CYP 2D6 mediated activation to an active metabolite, the structure of which has escaped definitive identification for over 75 years. CYP 2D6 is highly polymorphic among various human populations adding further complexity to a comprehensive understanding of primaquine pharmacology. This review aims to discuss primaquine pharmacology in the context of state of the art understanding of CYP 2D6 mediated 8-aminoquinoline metabolic activation, and shed light on the current knowledge gaps of 8-aminoquinoline mechanistic understanding against relapsing malaria. Published by Elsevier Inc. This is an open access article under the CC.BY-NC-ND license. C1 [Marcsisin, Sean R.; Reichard, Gregory] Walter Reed Army Inst Res, Expt Therapeut Branch, Mil Malaria Res Program, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. [Pybus, Brandon S.] Dwight D Eisenhower Army Med Ctr, Dept Pathol, Ft Gordon, GA 30905 USA. RP Marcsisin, SR (reprint author), Walter Reed Army Inst Res, Expt Therapeut Branch, Mil Malaria Res Program, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM sean.r.marcsisin.mil@mail.mil FU Military Infectious Disease Research Program (MIDRP) FX This work was supported in part by the Military Infectious Disease Research Program (MIDRP). https://midrp.amedd.army.mil/, NR 79 TC 2 Z9 2 U1 3 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0163-7258 J9 PHARMACOL THERAPEUT JI Pharmacol. Ther. PD MAY PY 2016 VL 161 BP 1 EP 10 DI 10.1016/j.pharmthera.2016.03.011 PG 10 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA DL8IV UT WOS:000375886600001 PM 27016470 ER PT J AU Waterman, BR Rensing, N Cameron, KL Owens, BD Pallis, M AF Waterman, Brian R. Rensing, Nicholas Cameron, Kenneth L. Owens, Brett D. Pallis, Mark TI Survivorship of Meniscal Allograft Transplantation in an Athletic Patient Population SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article DE meniscus; allograft transplantation; tear; extrusion ID SHOULDER ARTHROPLASTY; CLINICAL-OUTCOMES; FOLLOW-UP; KNEE; SURGEON; RECONSTRUCTION; SURVIVAL; VOLUME; RATES AB Background:There are limited data evaluating the clinical outcomes of meniscal allograft transplantation (MAT) in physically active cohorts. Purpose: To determine the survivorship, complication rates, and functional outcomes of MAT in an active military population. Study Design: Case series; Level of evidence, 4. Methods: All military patients undergoing MAT between 2007 and 2013 were identified from the Military Health System. Previous/concomitant procedures, perioperative complications, reoperation rate, revision, and initiation of medical discharge for persistent knee disability were recorded. Univariate analysis was performed to identify associations between patient-based and surgical variables on selected endpoints. Results: A total of 230 MATs (227 patients; 228 knees) were identified; the mean patient age was 27.2 years (range, 18-46 years), and the cohort was predominately male (89%). Approximately half (51%) of the patients had undergone prior, nonmeniscal knee procedures. Medial MATs were performed in 160 (69%) cases, and isolated MATs were most common (60%). A total of 51 complications occurred in 46 (21.1%) patients, including a secondary tear or extrusion (9%). At a mean clinical follow-up of 2.14 years, 10 (4.4%) patients required secondary meniscal debridement, while 1 (0.4%) patient required revision MAT and 2 (0.9%) patients underwent total knee arthroplasty. After MAT, 50 (22%) patients underwent knee-related military discharge at a mean of 2.49 years postoperatively. Tobacco use (P = .028) was associated with significantly increased risk of failure, and operation by fellowship-trained surgeons trended toward significance as a protective factor (P = .078). Furthermore, high-volume surgeons (1 MAT/year; range, 9-35) had significantly reduced rates of failure (P = .046). Conclusion: While reporting low reoperation and revision rates, this investigation indicates that 22% of patients with MAT were unable to return to military duty due to persistent knee limitations at short-term follow-up. Increased surgical experience may decrease rates of failure after MAT. Careful patient selection and referral to subspecialty-trained, higher-volume surgeons should be considered to optimize clinical outcomes after MAT. C1 [Waterman, Brian R.; Rensing, Nicholas; Cameron, Kenneth L.; Owens, Brett D.; Pallis, Mark] William Beaumont Army Med Ctr, El Paso, TX 79920 USA. [Waterman, Brian R.; Rensing, Nicholas; Pallis, Mark] William Beaumont Army Med Ctr, Dept Orthopaed Surg & Rehabil, El Paso, TX 79920 USA. [Cameron, Kenneth L.; Owens, Brett D.] US Mil Acad, Keller Army Hosp, John A Feagin Jr Sports Med Fellowship, West Point, NY 10996 USA. RP Owens, BD (reprint author), Brown Univ, Alpert Med Sch, Dept Orthopaed Surg, 100 Butler Dr, Providence, RI 02906 USA. EM owensbrett@gmail.com FU Mitek; Musculoskeletal Transplant Foundation FX One or more of the authors has declared the following potential conflict of interest or source of funding: B.D.O. is a paid consultant for Mitek and the Musculoskeletal Transplant Foundation. M.P. owns stock or stock options in Johnson & Johnson. NR 28 TC 1 Z9 1 U1 0 U2 3 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0363-5465 EI 1552-3365 J9 AM J SPORT MED JI Am. J. Sports Med. PD MAY PY 2016 VL 44 IS 5 BP 1237 EP 1242 DI 10.1177/0363546515626184 PG 6 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA DL4JD UT WOS:000375599600020 PM 26888878 ER PT J AU Files, BT Lawhern, VJ Ries, AJ Marathe, AR AF Files, Benjamin T. Lawhern, Vernon J. Ries, Anthony J. Marathe, Amar R. TI A Permutation Test for Unbalanced Paired Comparisons of Global Field Power SO BRAIN TOPOGRAPHY LA English DT Article DE Statistical test; Oddball paradigm; Data imbalance; Electroencephalography ID EVENT-RELATED POTENTIALS; MASS UNIVARIATE ANALYSIS; FALSE DISCOVERY RATE; MISMATCH NEGATIVITY; BRAIN; DIFFERENCE; AVERAGE; TRIALS; WAVE AB Global field power is a valuable summary of multi-channel electroencephalography data. However, global field power is biased by the noise typical of electroencephalography experiments, so comparisons of global field power on data with unequal noise are invalid. Here, we demonstrate the relationship between the number of trials that contribute to a global field power measure and the expected value of that global field power measure. We also introduce a statistical testing procedure that can be used for multi-subject, repeated-measures (also called within-subjects) comparisons of global field power when the number of trials per condition is unequal across conditions. Simulations demonstrate the effect of unequal trial numbers on global field power comparisons and show the validity of the proposed test in contrast to conventional approaches. Finally, the proposed test and two alternative tests are applied to data collected in a rapid serial visual presentation target detection experiment. The results show that the proposed test finds global field power differences in the classical P3 range; the other tests find differences in that range but also at other times including at times before stimulus onset. These results are interpreted as showing that the proposed test is valid and sensitive to real within-subject differences in global field power in multi-subject unbalanced data. C1 [Files, Benjamin T.; Lawhern, Vernon J.; Ries, Anthony J.; Marathe, Amar R.] US Army, Res Lab, Aberdeen Proving Ground, MD USA. RP Files, BT (reprint author), US Army, Res Lab, Aberdeen Proving Ground, MD USA. EM benjamin.t.files.civ@mail.mil FU U.S. Army Research Laboratory under a Director's Strategic Research Initiative; Office of the Secretary of Defense ARPI program [MIPR DWAM31168] FX This project was supported by The U.S. Army Research Laboratory under a Director's Strategic Research Initiative entitled "Heterogeneous Systems for Information Variable Environments (HIVE)," an appointment to the U.S. Army Research Laboratory Postdoctoral Fellowship program administered by the Oak Ridge Associated Universities through a cooperative agreement with the U.S. Army Research Laboratory and the Office of the Secretary of Defense ARPI program MIPR DWAM31168. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 35 TC 0 Z9 0 U1 0 U2 5 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0896-0267 EI 1573-6792 J9 BRAIN TOPOGR JI Brain Topogr. PD MAY PY 2016 VL 29 IS 3 BP 345 EP 357 DI 10.1007/s10548-016-0477-3 PG 13 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA DL7DH UT WOS:000375799600001 PM 26936593 ER PT J AU Beard, JD Engel, LS Richardson, DB Gammon, MD Baird, C Umbach, DM Allen, KD Stanwyck, CL Keller, J Sandler, DP Schmidt, S Kamel, F AF Beard, John D. Engel, Lawrence S. Richardson, David B. Gammon, Marilie D. Baird, Coleen Umbach, David M. Allen, Kelli D. Stanwyck, Catherine L. Keller, Jean Sandler, Dale P. Schmidt, Silke Kamel, Freya TI Military service, deployments, and exposures in relation to amyotrophic lateral sclerosis etiology SO ENVIRONMENT INTERNATIONAL LA English DT Article DE Amyotrophic lateral sclerosis; Case-control; Deployment; Etiology; Military ID MARGINAL STRUCTURAL MODELS; GULF-WAR VETERANS; MOTOR-NEURON DISEASE; MILLENNIUM COHORT; NATIONAL REGISTRY; OCCUPATIONAL-EXPOSURE; ANTHRAX VACCINATION; PESTICIDE EXPOSURE; VIETNAM VETERANS; TRAUMATIC EVENTS AB Background: Factors underlying a possible excess of amyotrophic lateral sclerosis (ALS) among military veterans remain unidentified. Limitations of previous studies on this topic include reliance on ALS mortality as a surrogate for ALS incidence, low statistical power, and sparse information on military-related factors. Objectives: We evaluated associations between military-related factors and ALS using data from a case-control study of U.S. military veterans. Methods: From 2005 to 2010, we identified medical record-confirmed ALS cases via the National Registry of Veterans with ALS and controls via the Veterans Benefits Administration's Beneficiary Identification and Records Locator System database. In total, we enrolled 621 cases and 958 frequency-matched controls in the Genes and Environmental Exposures in Veterans with Amyotrophic Lateral Sclerosis study. We collected information on military service and deployments and 39 related exposures. We used unconditional logistic regression models to estimate odds ratios (ORs) and 95% confidence intervals (CIs). We used inverse probability weighting to adjust for potential bias from confounding, missing covariate data, and selection arising from a case group that disproportionately included long-term survivors and a control group that may or may not differ from U.S. military veterans at large. Results: The odds of ALS did not differ for veterans of the Air Force, Army, Marines, and Navy. We found higher odds of ALS for veterans whose longest deployment was World War II or the Korean War and a positive trend with total years of all deployments (OR = 1.27; 95% CI: 1.06, 1.52). ALS was positively associated with exposure to herbicides for military purposes, nasopharyngeal radium, personal pesticides, exhaust from heaters or generators, high-intensity radar waves, contaminated food, explosions within one mile, herbicides in the field, mixing and application of burning agents, burning agents in the field, and Agent Orange in the field, with ORs between 1.50 and 7.75. Conclusions: Although our results need confirmation, they are potentially important given the large number of U.S. military veterans, and they provide clues to potential factors underlying the apparent increase of ALS in veteran populations. Published by Elsevier Ltd C1 [Beard, John D.; Engel, Lawrence S.; Richardson, David B.; Gammon, Marilie D.] Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA. [Beard, John D.; Sandler, Dale P.; Kamel, Freya] NIEHS, Epidemiol Branch, 111 TW Alexander Dr,A3-05, Res Triangle Pk, NC 27709 USA. [Baird, Coleen] US Army Publ Hlth Command, Environm Med Program, Aberdeen Proving Ground, MD USA. [Umbach, David M.] NIEHS, Biostat & Computat Biol Branch, 111 TW Alexander Dr,A3-05, Res Triangle Pk, NC 27709 USA. [Allen, Kelli D.; Stanwyck, Catherine L.] Durham VA Med Ctr, Durham, NC USA. [Allen, Kelli D.] Univ N Carolina, Dept Med, Chapel Hill, NC USA. [Allen, Kelli D.] Univ N Carolina, Thurston Arthrit Res Ctr, Chapel Hill, NC USA. [Stanwyck, Catherine L.; Schmidt, Silke] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA. [Keller, Jean] Westat Corp, Durham, NC USA. RP Kamel, F (reprint author), NIEHS, Epidemiol Branch, 111 TW Alexander Dr,A3-05, Res Triangle Pk, NC 27709 USA. EM kamel@niehs.nih.gov OI Engel, Lawrence/0000-0001-9268-4830; Kamel, Freya/0000-0001-5052-6615; Sandler, Dale/0000-0002-6776-0018 FU Intramural Research Program of the NIH; National Institute of Environmental Health Sciences (NIEHS) [Z01 ES049005]; NIEHS [R01 ES13244, T32ES007018]; ALS Association [ALSA 1230]; CDC; National Institute for Occupational Safety and Health [T42OH00867302]; U.S. Department of Veterans Affairs (CSP) [500A] FX This work was supported by the Intramural Research Program of the NIH, National Institute of Environmental Health Sciences (NIEHS; Z01 ES049005), grants from the NIEHS (R01 ES13244) and the ALS Association (ALSA 1230), and training grants from the NIEHS (T32ES007018) and the CDC, National Institute for Occupational Safety and Health (T42OH00867302). The National Registry of Veterans with ALS was supported by the U.S. Department of Veterans Affairs (CSP #500A). NR 59 TC 3 Z9 3 U1 2 U2 12 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0160-4120 EI 1873-6750 J9 ENVIRON INT JI Environ. Int. PD MAY PY 2016 VL 91 BP 104 EP 115 DI 10.1016/j.envint.2016.02.014 PG 12 WC Environmental Sciences SC Environmental Sciences & Ecology GA DL4TQ UT WOS:000375630500011 PM 26923711 ER PT J AU van Harmelen, T Zondervan-van den Beuken, EK Brouwer, DH Kuijpers, E Fransman, W Buist, HB Ligthart, TN Hincapie, I Hischier, R Linkov, I Nowack, B Studer, J Hilty, L Som, C AF van Harmelen, Toon Zondervan-van den Beuken, Esther K. Brouwer, Derk H. Kuijpers, Eelco Fransman, Wouter Buist, Harrie B. Ligthart, Tom N. Hincapie, Ingrid Hischier, Roland Linkov, Igor Nowack, Bernd Studer, Jennifer Hilty, Lorenz Som, Claudia TI LICARA nanoSCAN - A tool for the self-assessment of benefits and risks of nanoproducts SO ENVIRONMENT INTERNATIONAL LA English DT Article DE Risk assessment; Benefit assessment; Nanoproducts; Decision-making tool; Sustainable nanotechnology; Life Cycle Assessment ID NANOMATERIALS AB The fast penetration of nanoproducts on the market under conditions of significant uncertainty of their environmental properties and risks to humans creates a need for companies to assess sustainability of their products. Evaluation of the potential benefits and risks to build a coherent story for communication with clients, authorities, consumers, and other stakeholders is getting to be increasingly important, but SMEs often lack the knowledge and expertise to assess risks and communicate them appropriately. This paper introduces LICARA nanoSCAN, a modular web based tool that supports SMEs in assessing benefits and risks associated with new or existing nanoproducts. This tool is unique because it is scanning both the benefits and risks over the nanoproducts life cycle in comparison to a reference product with a similar functionality in order to enable the development of sustainable and competitive nanoproducts. SMEs can use data and expert judgment to answer mainly qualitative and semi-quantitative questions as a part of tool application. Risks to public, workers and consumers are assessed, while the benefits are evaluated for economic, environmental and societal opportunities associated with the product use. The tool provides an easy way to visualize results as well as to identify gaps, missing data and associated uncertainties. The LICARA nanoSCAN has been positively evaluated by several companies and was tested in a number of case studies. The tool helps to develop a consistent and comprehensive argument on the weaknesses and strengths of a nanoproduct that may be valuable for the communication with authorities, clients and among stakeholders in the value chain. LICARA nanoSCAN identifies areas for more detailed assessments, product design improvement or application of risk mitigation measures. (C) 2016 Elsevier Ltd. All rights reserved. C1 [van Harmelen, Toon; Ligthart, Tom N.] TNO, Climate Air & Sustainabil, POB 80015, NL-3508 TA Utrecht, Netherlands. [Zondervan-van den Beuken, Esther K.; Brouwer, Derk H.; Kuijpers, Eelco; Fransman, Wouter; Buist, Harrie B.] TNO, Risk Anal Prod Dev, POB 360, NL-3700 AJ Zeist, Netherlands. [Hincapie, Ingrid; Hischier, Roland; Nowack, Bernd; Hilty, Lorenz; Som, Claudia] Swiss Fed Labs Mat Sci & Technol, Empa, Technol & Soc Lab, Lerchenfeldstr 5, CH-9014 St Gallen, Switzerland. [Linkov, Igor] US Army Engineer Res & Dev Ctr, 696 Virginia Rd, Concord, MA 01742 USA. [Studer, Jennifer; Hilty, Lorenz] Univ Zurich, Dept Informat, Informat & Sustainabil Res Grp, Binzmuhlestr 14, CH-8050 Zurich, Switzerland. [Brouwer, Derk H.] Univ Witwatersrand, Sch Publ Hlth, 27 St Andrews Rd, ZA-2193 Johannesburg, South Africa. [Linkov, Igor] Carnegie Mellon Univ, Pittsburgh, PA 15213 USA. RP Zondervan-van den Beuken, EK (reprint author), TNO, Risk Anal Prod Dev, POB 360, NL-3700 AJ Zeist, Netherlands. EM esther.zondervan@tno.nl OI Hischier, Roland/0000-0002-1084-7665; Nowack, Bernd/0000-0002-5676-112X FU European Union Seventh Framework Programme (FP7) [315494] FX The research leading to these results received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement no. 315494 (LICARA). NR 37 TC 1 Z9 1 U1 4 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0160-4120 EI 1873-6750 J9 ENVIRON INT JI Environ. Int. PD MAY PY 2016 VL 91 BP 150 EP 160 DI 10.1016/j.envint.2016.02.021 PG 11 WC Environmental Sciences SC Environmental Sciences & Ecology GA DL4TQ UT WOS:000375630500015 PM 26949868 ER PT J AU Whitman, GM Wang, Q Spector, P Schwering, FK AF Whitman, Gerald M. Wang, Qi Spector, Paul Schwering, Felix K. TI Gaussian Beam Scattering From a Deterministic Rough Metal Surface SO IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION LA English DT Article DE Correction current (CC) method; Gaussian beam scattering; rough surface scattering ID INHOMOGENEOUS MULTILAYERED STRUCTURES; ELECTROMAGNETIC WAVE-PROPAGATION; TE-POLARIZATION; APPROXIMATION; THICKNESS AB A full-wave theory of plane wave scattering from rough surfaces called the correction current (CC) method was recently developed. This paper extends the CC method to the more general case of beam wave scattering. Gaussian beams are assumed incident upon a deterministic metal rough surface. Scatter patterns based on the CC method are calculated and compared to scatter patterns determined by the method of moments solution of an electric field integral equation formulation of the scatter problem. It was shown that good agreement between these two solution methods is obtained for scatter surfaces for which the CC method is shown to satisfy conservation of power and an accuracy criterion. C1 [Whitman, Gerald M.; Wang, Qi] New Jersey Inst Technol, Dept Elect & Comp Engn, Newark, NJ 07102 USA. [Wang, Qi] Ohio State Univ, Dept Elect & Comp Engn, Columbus, OH 43210 USA. [Spector, Paul] New Jersey Inst Technol, Dept Elect Engn, Newark, NJ 07102 USA. [Schwering, Felix K.] US Army, CERDEC, Ft Monmouth, NJ 07703 USA. RP Whitman, GM; Wang, Q (reprint author), New Jersey Inst Technol, Dept Elect & Comp Engn, Newark, NJ 07102 USA.; Wang, Q (reprint author), Ohio State Univ, Dept Elect & Comp Engn, Columbus, OH 43210 USA. EM whitman@njit.edu; wang.3726@osu.edu NR 13 TC 0 Z9 0 U1 2 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-926X EI 1558-2221 J9 IEEE T ANTENN PROPAG JI IEEE Trans. Antennas Propag. PD MAY PY 2016 VL 64 IS 5 BP 1868 EP 1876 DI 10.1109/TAP.2016.2537383 PG 9 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA DL4HX UT WOS:000375596100030 ER PT J AU Yamashita, H Jayakumar, P Sugiyama, H AF Yamashita, Hiroki Jayakumar, Paramsothy Sugiyama, Hiroyuki TI Physics-Based Flexible Tire Model Integrated With LuGre Tire Friction for Transient Braking and Cornering Analysis SO JOURNAL OF COMPUTATIONAL AND NONLINEAR DYNAMICS LA English DT Article ID ABSOLUTE NODAL COORDINATE; 4-NODE SHELL ELEMENT; OPTIMAL SOLID SHELLS; NONLINEAR ANALYSES; MULTILAYER COMPOSITES; TYRE MODEL; FORMULATION; PLATE AB In transient vehicle maneuvers, structural tire deformation due to the large load transfer causes abrupt change in normal contact pressure and slip distribution over the contact patch, and it has a dominant effect on characterizing the transient braking and cornering forces including the history-dependent friction-induced hysteresis effect. To account for the dynamic coupling of structural tire deformations and the transient tire friction behavior, a physics-based flexible tire model is developed using the laminated composite shell element based on the absolute nodal coordinate formulation and the distributed parameter LuGre tire friction model. In particular, a numerical procedure to integrate the distributed parameter LuGre tire friction model into the finite-element based spatial flexible tire model is proposed. To this end, the spatially discretized form of the LuGre tire friction model is derived and integrated into the finite-element tire model such that change in the normal contact pressure and slip distributions over the contact patch predicted by the deformable tire model enters into the spatially discretized LuGre tire friction model to predict the transient shear contact stress distribution. By doing so, the structural tire deformation and the LuGre tire friction force model are dynamically coupled in the final form of the equations, and these equations are integrated simultaneously forward in time at every time step. The tire model developed is experimentally validated and several numerical examples for hard braking and cornering simulation are presented to demonstrate capabilities of the physics-based flexible tire model developed in this study. C1 [Yamashita, Hiroki] Univ Iowa, Dept Mech & Ind Engn, Seamans Ctr 2312, Iowa City, IA 52242 USA. [Jayakumar, Paramsothy] US Army TARDEC, 6501 E 11 Mile Rd, Warren, MI 48397 USA. [Sugiyama, Hiroyuki] Univ Iowa, Dept Mech & Ind Engn, Seamans Ctr 2416C, Iowa City, IA 52242 USA. RP Sugiyama, H (reprint author), Univ Iowa, Dept Mech & Ind Engn, Seamans Ctr 2416C, Iowa City, IA 52242 USA. EM hiroyuki-sugiyama@uiowa.edu FU Automotive Research Center (ARC) [W56HZV-04-2-0001]; U.S. Army Tank Automotive Research, Development and Engineering Center (TARDEC); Yokohama Rubber Co., Ltd. FX This research was supported by the Automotive Research Center (ARC) in accordance with Cooperative Agreement No. W56HZV-04-2-0001 U.S. Army Tank Automotive Research, Development and Engineering Center (TARDEC), and Yokohama Rubber Co., Ltd. This material is declared a work of the U.S. Government and is not subject to copyright protection in the United States. Approved for public release; distribution is unlimited. NR 49 TC 0 Z9 0 U1 6 U2 10 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 1555-1423 EI 1555-1415 J9 J COMPUT NONLIN DYN JI J. Comput. Nonlinear Dyn. PD MAY PY 2016 VL 11 IS 3 AR 031017 DI 10.1115/1.4032855 PG 17 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA DJ2NF UT WOS:000374040900017 ER PT J AU Abdullatif, J Certal, V Zaghi, S Song, SA Chang, ET Gillespie, MB Camacho, M AF Abdullatif, Jose Certal, Victor Zaghi, Soroush Song, Sungjin A. Chang, Edward T. Gillespie, M. Boyd Camacho, Macario TI Maxillary expansion and maxillomandibular expansion for adult OSA: A systematic review and meta-analysis SO JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY LA English DT Review DE Maxillary expansion; Maxillomandibular expansion; Sleep apnoea syndromes; Systematic review; Meta-analysis ID OBSTRUCTIVE SLEEP-APNEA AB Objective: This study sought to systematically review the international literature for articles evaluating maxillary expansion and maxillomandibular expansion as treatments for obstructive sleep apnea (OSA) in adults and to perform a meta-analysis. Data sources: Nine databases (including MEDLINE/PubMed). Review methods: Searches were performed through January 8, 2016. The PRISMA statement was followed. Results: Eight adult studies (39 patients) reported polysomnography and/or sleepiness outcomes. Six studies reported outcomes for maxillary expansion (36 patients), and the apnea-hypopnea index (AHI) decreased from a mean (M) +/- standard deviation (SD) of 24.3 +/- 27.5 [95% CI 153, 33.3] to 9.9 +/- 13.7 [95% CI 5.4, 14.4] events/hr (relative reduction: 593%). Maxillary expansion improved lowest oxygen saturation (LSAT) from a M +/- SD of 84.3 +/- 8.1% [95% CI 81.7, 87.0] to 86.9 +/- 5.6% [95% CI 85.1, 88.7]. Maxillomandibular expansion was reported in two studies (3 patients) and AHI decreased from a M +/- SD of 47.53 +/- 29.81 [95% CI -26.5 to 121.5] to 10.7 +/- 3.2 [95% CI 2.8, 18.6] events/hr (relative reduction: 77.5%). Maxillomandibular expansion improved LSAT from a M SD of 76.7 +/- 14.5% [95% CI 40.7, 112.7] to 89.3 +/- 3.1 [95% CI 81.6, 97]. Conclusion: The current literature demonstrates that maxillary expansion can improve and maxillomandibular expansion can possibly improve AHI and LSAT in adults; however, given the paucity of studies, these remain open for additional research efforts. (C) 2016 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved. C1 [Abdullatif, Jose] Hosp Bernardino Rivadavia, Dept Otorhinolaryngol, Buenos Aires, DF, Argentina. [Certal, Victor] Hosp CUF, Sleep Med Ctr, Dept Otorhinolaryngol, Oporto, Portugal. [Certal, Victor] Univ Porto, CINTESIS Ctr Res Hlth Technol & Informat Syst, Rua Campo Alegre 823, P-4100 Oporto, Portugal. [Zaghi, Soroush] Stanford Hosp & Clin, Div Sleep Surg, Dept Otolaryngol Head & Neck Surg, Stanford, CA 95304 USA. [Song, Sungjin A.; Chang, Edward T.] Tripler Army Med Ctr, Otolaryngol Head & Neck Surg, Honolulu, HI 96859 USA. [Gillespie, M. Boyd] Med Univ S Carolina, Dept Otolaryngol Head & Neck Surg, Charleston, SC 29425 USA. [Camacho, Macario] Tripler Army Med Ctr, Div Sleep Surg & Med, Otolaryngol Head & Neck Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. [Camacho, Macario] Stanford Hosp & Clin, Sleep Med Div, Dept Psychiat & Behav Sci, Stanford, CA 95304 USA. RP Camacho, M (reprint author), Tripler Army Med Ctr, Div Sleep Surg & Med, Otolaryngol Head & Neck Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA.; Camacho, M (reprint author), Stanford Hosp & Clin, Sleep Med Div, Dept Psychiat & Behav Sci, Stanford, CA 95304 USA. EM drcamachoent@yahoo.com RI FMUP, CINTESIS/C-6631-2014 OI FMUP, CINTESIS/0000-0001-7248-2086 NR 23 TC 0 Z9 0 U1 3 U2 3 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND SN 1010-5182 EI 1878-4119 J9 J CRANIO MAXILL SURG JI J. Cranio-MaxilloFac. Surg. PD MAY PY 2016 VL 44 IS 5 BP 574 EP 578 DI 10.1016/j.jcms.2016.02.001 PG 5 WC Dentistry, Oral Surgery & Medicine; Surgery SC Dentistry, Oral Surgery & Medicine; Surgery GA DL6GS UT WOS:000375738300007 PM 26948172 ER PT J AU Armstrong, MJ Beris, AN Rogers, SA Wagner, NJ AF Armstrong, Matthew J. Beris, Antony N. Rogers, Simon A. Wagner, Norman J. TI Dynamic shear rheology of a thixotropic suspension: Comparison of an improved structure-based model with large amplitude oscillatory shear experiments SO JOURNAL OF RHEOLOGY LA English DT Article ID YIELD-STRESS FLUIDS; MICELLAR-SOLUTIONS; HUMAN-BLOOD; VISCOSITY; BEHAVIOR; FLOW; DISPERSIONS; LAOS; SYSTEMS; GEL AB Rheological measurements on a model thixotropic suspension by Dullaert and Mewis [J. Non-Newtonian Fluid Mech. 139(1-2), 21-30 (2006); Rheol. Acta 45, 23-32 (2005)] are extended to include large amplitude oscillatory shear (LAOS) flow, shear flow reversal, and a novel unidirectional LAOS flow to provide an extended rheological data set for testing constitutive models. We use this extended data set to test a new structure-based model developed by improving the Delaware thixotropic model [A. Mujumdar et al., J. Non-Newtonian Fluid Mech. 102,157-178 (2002); A. J. Apostolidis et al., J. Rheol. 59, 275-298 (2015)]. Model parameters are determined from steady, small amplitude oscillatory, and step shear rate tests. Holding those parameters fixed, model predictions are compared to LAOS experiments. Similar comparisons are made for three contemporary models from the literature. Two of these models use a scalar internal structural parameter and include the modified Jeffreys model proposed by de Souza Mendes and Thompson [Rheol. Acta 52, 673-694 (2013)]. The third model is based on fluidity additivity [F. Bautista et al., J. Non-Newtonian Fluid Mech. 80, 93-113 (1999)]. A common weakness in all models is shown to be the use of scalar order parameters that cannot account for the reversal of flow directionality inherent in LAOS flow. This is further illustrated by comparison with flow reversal and unidirectional LAOS experiments. (C) 2016 The Society of Rheology. C1 [Armstrong, Matthew J.; Beris, Antony N.; Rogers, Simon A.; Wagner, Norman J.] Univ Delaware, Dept Chem & Biomol Engn, Newark, DE 19716 USA. [Armstrong, Matthew J.] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. [Rogers, Simon A.] Univ Illinois, Dept Chem & Biomol Engn, Champaign, IL 61801 USA. RP Wagner, NJ (reprint author), Univ Delaware, Dept Chem & Biomol Engn, Newark, DE 19716 USA. EM wagnemj@udel.edu RI Wagner, Norman/B-6558-2012; Rogers, Simon/E-4215-2013 OI Wagner, Norman/0000-0001-9565-619X; Rogers, Simon/0000-0002-3432-5044 FU National Science Foundation [CBET 312146]; U.S. Army; Department of Chemistry and Life Science, United States Military Academy FX The authors acknowledge the support of the National Science Foundation through Grant No. CBET 312146, the funding assistance from the U.S. Army, and the Department of Chemistry and Life Science, United States Military Academy. Paulo de Souza Mendes (PUC, Brazil) is gratefully acknowledged for significant assistance with the UA models fitting and for helpful suggestions throughout this work. The authors gratefully acknowledge the contributions of Jan Mewis (KU Leuven, emeritus) for help with the model system used in this work, as well as for many helpful suggestions and guidance throughout this work. The views expressed herein are those of the authors and do not reflect the position of the United States Military Academy, the Department of the Army, or the Department of Defense. NR 60 TC 5 Z9 5 U1 10 U2 24 PU JOURNAL RHEOLOGY AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0148-6055 J9 J RHEOL JI J. Rheol. PD MAY-JUN PY 2016 VL 60 IS 3 BP 433 EP 450 DI 10.1122/1.4943986 PG 18 WC Mechanics SC Mechanics GA DL8IZ UT WOS:000375887000007 ER PT J AU Chaitaveep, N Utachee, P Chuenchitra, T Karasavvan, N Takeda, N Kameoka, M AF Chaitaveep, Nithinart Utachee, Piraporn Chuenchitra, Thippawan Karasavvan, Nicos Takeda, Naokazu Kameoka, Masanori TI Neutralization breadth and potency of serum derived from recently human immunodeficiency virus type 1-infected Thai individuals SO MICROBES AND INFECTION LA English DT Article DE Recent HIV-1 infection; Neutralization; CRF01_AE; Thailand ID HIV TYPE-1; FUSION INHIBITOR; ENV CLONES; ANTIBODIES; INFECTION; SEROCONVERSION; PLASMA; ESCAPE; CELLS; ASSAY AB Neutralizing antibody responses play important roles in controlling several viral infections including human immunodeficiency virus type 1 (HIV-1). Potent and broad neutralizing antibody responses have been reported in some HIV-1-infected individuals; therefore, elucidating the mechanisms underlying neutralizing antibody responses will provide important information for the development of anti-HIV-1 vaccines. We herein performed a comparative study on the neutralization breadth and potency of serum samples collected from Thai individuals recently and chronically infected with HIV-1. Neutralization tests using a series of envelope glycoproteins (Env)-recombinant viruses revealed that although several serum samples derived from recently infected individuals did not show any HIV-1-specific neutralizing activity, the remaining serum samples exhibited neutralizing activity not only for recombinant viruses with CRF01_AE Env, but also for viruses with subtypes B and C Env. Furthermore, some serum samples derived from recently infected individuals showed the neutralization potency. Our results may provide a deeper insight into the characteristics of neutralizing antibody responses that develop during the course of HIV-1 infection among individuals in Thailand. (C) 2016 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved. C1 [Chaitaveep, Nithinart; Chuenchitra, Thippawan; Karasavvan, Nicos] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Utachee, Piraporn; Takeda, Naokazu] Thailand Japan Res Collaborat Ctr Emerging & Reem, Nonthaburi, Thailand. [Takeda, Naokazu; Kameoka, Masanori] Osaka Univ, Microbial Dis Res Inst, Osaka, Japan. [Kameoka, Masanori] Kobe Univ, Grad Sch Hlth Sci, Dept Int Hlth, Kobe, Hyogo, Japan. RP Kameoka, M (reprint author), Kobe Univ, Grad Sch Hlth Sci, Dept Int Hlth, Suma Ku, 7-10-2 Tomogaoka, Kobe, Hyogo 6540142, Japan. EM mkameoka@port.kobe-u.ac.jp OI Kameoka, Masanori/0000-0001-5525-9915 FU Government Lottery Office of Thailand; Research Institute for Microbial Diseases, Osaka University; program of the Japan Initiative for Global Research Network on Infectious Diseases (J-GRID) by the Japan Agency for Medical Research and Development (AMED) FX We are grateful to the staff of the Armed Forces Research Institute of Medical Sciences (AFRIMS), especially Dr. Sathit Pichyangkul and Mr. Kosol Yongvanichit, for their valuable help with this study. This work was supported in part by a research grant by the Government Lottery Office of Thailand; a collaborative research grant by the Research Institute for Microbial Diseases, Osaka University; and the program of the Japan Initiative for Global Research Network on Infectious Diseases (J-GRID) by the Japan Agency for Medical Research and Development (AMED). The opinions or assertions presented in this study are the private views of the authors and are not to be construed as reflecting the official positions of the Royal Thai Army. The HIV-1 env genes, pREJO4541.67, QH0692.42, ZM249M.PL1 and ZM53M.PB12, and cell lines, U87.CD4.CXCR4 and U87.CD4.CCR5, were obtained through the AIDS Research and Reference Reagent Program, Division of AIDS, NIAID, NIH. This manuscript was proofread by Medical English Service (Kyoto, Japan). NR 37 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1286-4579 EI 1769-714X J9 MICROBES INFECT JI Microbes Infect. PD MAY PY 2016 VL 18 IS 5 BP 346 EP 353 DI 10.1016/j.micinf.2015.12.009 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA DL3XY UT WOS:000375568200007 PM 26774333 ER PT J AU Mallick, LM Mitchell, MM Millikan-Bell, A Gallaway, MS AF Mallick, Lindsay M. Mitchell, Mary M. Millikan-Bell, Amy Gallaway, M. Shayne TI Small Unit Leader Perceptions of Managing Soldier Behavioral Health and Associated Factors SO MILITARY PSYCHOLOGY LA English DT Article DE behavioral health; leadership; military; squad leaders ID TRANSFORMATIONAL LEADERSHIP; COMBAT DEPLOYMENT; WORK ENGAGEMENT; SOCIAL COHESION; SELF-STIGMA; CARE; BARRIERS; ATTITUDES; RESILIENCE; MILITARY AB This investigation explored squad leaders' perceptions of their roles managing subordinate soldiers' behavioral health (BH) needs. The data were obtained through an anonymous survey of 458 squad leaders (i.e., small unit leaders who oversee 4-10 soldiers). More than 80% of squad leaders perceived management of soldier BH needs before, during, and after treatment as their responsibility, and felt comfortable and capable of executing these roles. Latent class analysis was used to determine groups of "most active," "moderately active," and "least active" leaders. Multinomial logistic regression was used to compare the least and most active classes. The most active leaders were more likely to report high BH knowledge, dedication to a common purpose, and low levels of "associative" stigma. These results should inform leader management of soldier BH. Future research should examine active leader characteristics and whether evidence-based training can increase support for preventing and managing BH issues. C1 [Mallick, Lindsay M.; Mitchell, Mary M.; Millikan-Bell, Amy; Gallaway, M. Shayne] US Army Publ Hlth Command, BSHOP, US Army Inst Publ Hlth, Aberdeen Proving Ground, MD 21010 USA. RP Gallaway, MS (reprint author), US Army Publ Hlth Command, APG EA, 5158 Blackhawk Rd, Aberdeen, MD 21010 USA. EM michael.gallaway@cdc.hhs.gov NR 56 TC 0 Z9 0 U1 4 U2 4 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0899-5605 EI 1532-7876 J9 MIL PSYCHOL JI Milit. Psychol. PD MAY PY 2016 VL 28 IS 3 BP 147 EP 161 DI 10.1037/mil0000101 PG 15 WC Psychology, Multidisciplinary SC Psychology GA DL6ZL UT WOS:000375788500003 ER PT J AU Justin, GA Chang, ET Camacho, M Brietzke, SE AF Justin, Grant A. Chang, Edward T. Camacho, Macario Brietzke, Scott E. TI Transoral Robotic Surgery for Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Review DE obstructive sleep apnea; transoral robotic surgery; TORS; sleep-disordered breathing; base of tongue ID HYPOPNEA SYNDROME; MIDLINE GLOSSECTOMY; TONGUE BASE; APNEA/HYPOPNEA SYNDROME; LINGUAL TONSILLECTOMY; CLINICAL-EXPERIENCE; TORS; UVULOPALATOPHARYNGOPLASTY; COMPLICATIONS; FEASIBILITY AB Objective To perform a systematic review of the international biomedical literature evaluating the effectiveness, complications, and safety of transoral robotic surgery (TORS) for the treatment of obstructive sleep apnea (OSA). Data Sources PubMed/MEDLINE, Embase, and EMB Reviews databases were searched up to November 27, 2015. Review Methods Two authors systematically and independently searched for articles on TORS for the treatment of OSA in adults that reported either outcomes for the apnea-hypopnea index (AHI), lowest oxygen saturation percentage (LSAT) or changes in the Epworth Sleepiness Scale (ESS), and/or rates and types of complications associated with the operation. Results In total, 181 records were identified and 16 articles met inclusion criteria. Transoral robotic surgery was almost always combined with other sleep surgery procedures. The summary estimate of the decrease in AHI using TORS as part of a multilevel surgical approach was 24.0 (95% confidence interval [CI], 22.1-25.8; P < .001, I-2 = 99%). The summary estimate of a decrease in ESS score was 7.2 (95% CI, 6.6-7.7; P < .001, I-2 = 99%) and of the overall surgical success (defined as AHI <20 and 50% reduction) was 48.2% (95% CI, 38.8%-57.7%; P < .001, I-2 = 99%). Three large studies reported on their total complication rates with an average of 22.3% (range, 20.5%-24.7%). Conclusions The initial results for the use of TORS as part of a multilevel surgical approach for OSA are promising for select patients. However, the cost and morbidity may be greater than with other techniques offsetting its advantages in visualization and precision. More prospective studies are needed to determine the optimal role of this tool. C1 [Justin, Grant A.] Uniformed Serv Univ Hlth Sci, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. [Chang, Edward T.; Camacho, Macario] Tripler Army Med Ctr, Dept Otolaryngol Head & Neck Surg, Honolulu, HI 96859 USA. [Brietzke, Scott E.] Walter Reed Natl Mil Med Ctr, Dept Otolaryngol Head & Neck Surg, Bethesda, MD USA. RP Justin, GA (reprint author), Uniformed Serv Univ Hlth Sci, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM grant.a.justin@gmail.com NR 39 TC 0 Z9 0 U1 3 U2 4 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0194-5998 EI 1097-6817 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD MAY PY 2016 VL 154 IS 5 BP 835 EP 846 DI 10.1177/0194599816630962 PG 12 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA DL4HB UT WOS:000375593800011 PM 26932967 ER PT J AU Hudspeth, M Chen, WN Zheng, J AF Hudspeth, Matthew Chen, Weinong Zheng, James TI Why the Smith theory over-predicts instant rupture velocities during fiber transverse impact SO TEXTILE RESEARCH JOURNAL LA English DT Article DE fiber transverse impact; yarn; Kevlar (R); rupture velocity ID FRAGMENT-SIMULATING PROJECTILES; NYLON BALLISTIC PANELS; SINGLE FIBERS; CUT RESISTANCE; PENETRATION; FAILURE; YARNS; CLOTH AB The effect of multi-axial loading on single Kevlar (R) KM2 fibers is explored with an emphasis on correlating the results to fiber/yarn transverse impact. A 0.30 caliber fragment simulation projectile (FSP) is slightly modified to act as a transverse loading indenter. Fiber failure angles are forced between similar to 0 degrees and 50 degrees in efforts to deduce the deleterious effect caused by such angles. Said angles are also enforced in order to create the geometry that would be produced at an impact velocity causing immediate fiber/yarn rupture in transverse impact experiments. The effect of fiber angle around the FSP indenter is experimentally studied along with an analysis of the specific angle causing immediate fiber failure. It is shown that there exists a demonstrative reduction in fiber longitudinal failure strain of KM2 filaments due to this multi-axial stress state, thereby questioning the recurrent assumption that fiber performance within a body armor system is dominated by failure in pure tension. C1 [Hudspeth, Matthew; Chen, Weinong] Purdue Univ, Sch Aeronaut & Astronaut, W Lafayette, IN 47907 USA. [Chen, Weinong] Purdue Univ, Sch Mat Engn, W Lafayette, IN 47907 USA. [Zheng, James] US Army, Program Execut Off Soldier, Ft Belvoir, VA USA. RP Chen, WN (reprint author), Purdue Univ, Sch Aeronaut & Astronaut, W Lafayette, IN 47907 USA. EM wchen@purdue.edu FU US Army Program Executive Office - Soldiers; Purdue University FX This research was supported through a corporative agreement between US Army Program Executive Office - Soldiers and Purdue University. NR 39 TC 0 Z9 0 U1 2 U2 3 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0040-5175 EI 1746-7748 J9 TEXT RES J JI Text. Res. J. PD MAY PY 2016 VL 86 IS 7 BP 727 EP 738 DI 10.1177/0040517515586158 PG 12 WC Materials Science, Textiles SC Materials Science GA DL6AS UT WOS:000375719900006 ER PT J AU Skimmyhorn, W AF Skimmyhorn, William TI Assessing Financial Education: Evidence from Boot Camp SO AMERICAN ECONOMIC JOURNAL-ECONOMIC POLICY LA English DT Article ID INFORMATION; DECISIONS; LITERACY; OUTCOMES AB This study estimates the effects of Personal Financial Management Course attendance and enrollment assistance using a natural experiment in the US Army. New enlistees' course attendance reduces the probability of having credit account balances, average balances, delinquencies, and adverse legal actions in the first year after the course, but it has no effects on accounts in the second year or credit scores in either year. The course and its enrollment assistance substantially increase retirement savings rates and average monthly contributions, with effects that persist through at least two years. The course has no significant effects on military labor market outcomes. C1 [Skimmyhorn, William] US Mil Acad, Dept Social Sci, Off Econ & Manpower Anal, 607 Cullum Rd, West Point, NY 10996 USA. RP Skimmyhorn, W (reprint author), US Mil Acad, Dept Social Sci, Off Econ & Manpower Anal, 607 Cullum Rd, West Point, NY 10996 USA. EM william.skimmyhorn@usma.edu NR 23 TC 3 Z9 3 U1 3 U2 7 PU AMER ECONOMIC ASSOC PI NASHVILLE PA 2014 BROADWAY, STE 305, NASHVILLE, TN 37203 USA SN 1945-7731 EI 1945-774X J9 AM ECON J-ECON POLIC JI Am. Econ. J.-Econ. Policy PD MAY PY 2016 VL 8 IS 2 BP 322 EP 343 DI 10.1257/pol.20140283 PG 22 WC Economics SC Business & Economics GA DL2GZ UT WOS:000375453000010 ER PT J AU Seehusen, DA Egitto, EA AF Seehusen, Dean A. Egitto, Elizabeth A. TI AntiViral Therapy for Bell Palsy SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID STEROIDS C1 [Seehusen, Dean A.; Egitto, Elizabeth A.] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA USA. RP Seehusen, DA (reprint author), Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA USA. NR 6 TC 0 Z9 0 U1 1 U2 1 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X EI 1532-0650 J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD MAY 1 PY 2016 VL 93 IS 9 BP 742 EP 743 PG 2 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA DL1BW UT WOS:000375368000004 PM 27175950 ER PT J AU Lazarus, N Bedair, SS AF Lazarus, N. Bedair, S. S. TI Improved power transfer to wearable systems through stretchable magnetic composites SO APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING LA English DT Article ID ELECTRONICS; INDUCTORS; DESIGN AB The use of wireless power transfer is common in stretchable electronics since physical wiring can be easily destroyed as the system is stretched. This work presents the first demonstration of improved inductive power coupling to a stretchable system through the addition of a thin layer of ferroelastomeric material. A ferroelastomer, an elastomeric polymer loaded with magnetic particulates, has a permeability greater than one while retaining the ability to survive significant mechanical strains. A recently developed ferroelastomer composite based on sendust platelets within a soft silicone elastomer was incorporated into liquid metal stretchable inductors based on the liquid metal galinstan in fluidic channels. For a single-turn inductor, the maximum power transfer efficiency rises from 71 % with no backplane, to 81 % for a rigid ferrite backplane on the transmitter side alone, to 86 % with a ferroelastomer backplane on the receiver side as well. The coupling between a commercial wireless power transmitter coil with ferrite backplane to a five-turn liquid metal inductor was also investigated, finding an improvement in power transfer efficiency from 81 % with only a rigid backplane to 90 % with the addition of the ferroelastomer backplane. Both the single and multi-turn inductors were demonstrated surviving up to 50 % uniaxial applied strain. C1 [Lazarus, N.; Bedair, S. S.] US Army, Res Lab, Sensors & Elect Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RP Lazarus, N (reprint author), US Army, Res Lab, Sensors & Elect Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM nathan.lazarus2.civ@mail.mil NR 22 TC 0 Z9 0 U1 5 U2 9 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0947-8396 EI 1432-0630 J9 APPL PHYS A-MATER JI Appl. Phys. A-Mater. Sci. Process. PD MAY PY 2016 VL 122 IS 5 AR 543 DI 10.1007/s00339-016-0067-y PG 7 WC Materials Science, Multidisciplinary; Physics, Applied SC Materials Science; Physics GA DL2EJ UT WOS:000375445700056 ER PT J AU Jones, A AF Jones, Alvin TI Repeatable Battery for the Assessment of Neuropsychological Status: Effort Index Cutoff Scores for Psychometrically Defined Malingering Groups in a Military Sample SO ARCHIVES OF CLINICAL NEUROPSYCHOLOGY LA English DT Article DE RBANS; Effort Index; Performance validity testing; Malingering; military ID SYMPTOM VALIDITY TEST; TRAUMATIC BRAIN-INJURY; HENRY-HEILBRONNER INDEX; RESPONSE BIAS SCALE; FAKE BAD SCALE; CLASSIFICATION ACCURACY; NEUROCOGNITIVE DYSFUNCTION; DISABILITY CLAIMANTS; LIKELIHOOD RATIOS; TEST-PERFORMANCE AB Objective. This research examined cutoff scores for the Effort Index (EI), an embedded measure of performance validity, for the Repeatable Battery for the Assessment of Neuropsychological Status. EI cutoffs were explored for an active-duty military sample composed mostly of patients with traumatic brain injury. Method. Four psychometrically defined malingering groups including a definite malingering, probable to definite malingering, probable malingering, and a combined group were formed based on the number of validity tests failed. Results. Excellent specificities (0.97 or greater) were found for all cutoffs examined (EI >= 1 to EI >= 3). Excellent sensitivities (0.80 to 0.89) were also found for the definite malingering group. Sensitivities were 0.49 or below for the other groups. Positive and negative predictive values and likelihood ratios indicated that the cutoffs for EI were much stronger for ruling-in than ruling-out malingering. Analyses indicated the validity tests used to form the malingering groups were uncorrelated, which serves to enhance the validity of the formation of the malingering groups. Conclusions. Cutoffs were similar to other research using samples composed predominantly of head-injured individuals. C1 [Jones, Alvin] Womack Army Med Ctr, Ft Bragg, NC USA. RP Jones, A (reprint author), Dept Behav Hlth, 2817 Riley Rd,Bldg 4-2817, Ft Bragg, NC 28310 USA. EM alrobj@googlemail.com NR 70 TC 0 Z9 0 U1 2 U2 4 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0887-6177 EI 1873-5843 J9 ARCH CLIN NEUROPSYCH JI Arch. Clin. Neuropsychol. PD MAY PY 2016 VL 31 IS 3 BP 273 EP 283 DI 10.1093/arclin/acw006 PG 11 WC Psychology, Clinical; Psychology SC Psychology GA DL1WX UT WOS:000375424900008 PM 26972457 ER PT J AU Ratziu, V Harrison, SA Francque, S Bedossa, P Lehert, P Serfaty, L Romero-Gomez, M Boursier, J Abdelmalek, M Caldwell, S Drenth, JPH Anstee, QM Hum, D Hanf, R Roudot, A Megnien, S Staels, B Sanyal, A AF Ratziu, Vlad Harrison, Stephen A. Francque, Sven Bedossa, Pierre Lehert, Philippe Serfaty, Lawrence Romero-Gomez, Manuel Boursier, Jerome Abdelmalek, Manal Caldwell, Steve Drenth, Joost P. H. Anstee, Quentin M. Hum, Dean Hanf, Remy Roudot, Alice Megnien, Sophie Staels, Bart Sanyal, Arun CA GOLDEN-505 Investigator Study Grp TI Elafibranor, an Agonist of the Peroxisome Proliferator-Activated Receptor-alpha and -delta, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening SO GASTROENTEROLOGY LA English DT Article DE PPARA; PPARD; NAFLD; fatty liver ID FATTY LIVER-DISEASE; PLACEBO-CONTROLLED TRIAL; CLINICAL-OUTCOMES; FOLLOW-UP; VITAMIN-E; PIOGLITAZONE; METABOLISM; MORTALITY; THERAPY; GFT505 AB BACKGROUND & AIMS: Elafibranor is an agonist of the peroxisome proliferator-activated receptor-alpha and peroxisome proliferator-activated receptor-delta. Elafibranor improves insulin sensitivity, glucose homeostasis, and lipid metabolism and reduces inflammation. We assessed the safety and efficacy of elafibranor in an international, randomized, double-blind placebo-controlled trial of patients with nonalcoholic steatohepatitis (NASH). METHODS: Patients with NASH without cirrhosis were randomly assigned to groups given elafibranor 80 mg (n = 93), elafibranor 120 mg (n = 91), or placebo (n = 92) each day for 52 weeks at sites in Europe and the United States. Clinical and laboratory evaluations were performed every 2 months during this 1-year period. Liver biopsies were then collected and patients were assessed 3 months later. The primary outcome was resolution of NASH without fibrosis worsening, using protocol-defined and modified definitions. Data from the groups given the different doses of elafibranor were compared with those from the placebo group using step-down logistic regression, adjusting for baseline nonalcoholic fatty liver disease activity score. RESULTS: In intention-to-treat analysis, there was no significant difference between the elafibranor and placebo groups in the protocol-defined primary outcome. However, NASH resolved without fibrosis worsening in a higher proportion of patients in the 120-mg elafibranor group vs the placebo group (19% vs 12%; odds ratio = 2.31; 95% confidence interval: 1.02-5.24; P = .045), based on a post-hoc analysis for the modified definition. In post-hoc analyses of patients with nonalcoholic fatty liver disease activity score >= 4 (n = 234), elafibranor 120 mg resolved NASH in larger proportions of patients than placebo based on the protocol definition (20% vs 11%; odds ratio = 3.16; 95% confidence interval: 1.22-8.13; P = .018) and the modified definitions (19% vs 9%; odds ratio = 3.52; 95% confidence interval: 1.32-9.40; P = .013). Patients with NASH resolution after receiving elafibranor 120 mg had reduced liver fibrosis stages compared with those without NASH resolution (mean reduction of 0.65 +/- 0.61 in responders for the primary outcome vs an increase of 0.10 +/- 0.98 in nonresponders; P < .001). Liver enzymes, lipids, glucose profiles, and markers of systemic inflammation were significantly reduced in the elafibranor 120-mg group vs the placebo group. Elafibranor was well tolerated and did not cause weight gain or cardiac events, but did produce a mild, reversible increase in serum creatinine (effect size vs placebo: increase of 4.31 +/- 1.19 mmol/L; P < .001). CONCLUSIONS: A post-hoc analysis of data from trial of patients with NASH showed that elafibranor (120 mg/d for 1 year) resolved NASH without fibrosis worsening, based on a modified definition, in the intention-to-treat analysis and in patients with moderate or severe NASH. However, the predefined end point was not met in the intention to treat population. Elafibranor was well tolerated and improved patients' cardiometabolic risk profile. ClinicalTrials.gov number: NCT01694849. C1 [Ratziu, Vlad] Univ Paris 06, Hosp Pitie Salpetriere, 47-83 Bd Hop, F-75013 Paris, France. [Ratziu, Vlad] INSERM, Inst Cardiometab & Nutr, UMRS 938, Paris, France. [Harrison, Stephen A.] Brooke Army Med Ctr, Dept Med Gastroenterol & Hepatol Serv, Ft Sam Houston, TX 78234 USA. [Francque, Sven] Univ Antwerp, Univ Antwerp Hosp, Dept Gastroenterol & Hepatol, B-2020 Antwerp, Belgium. [Bedossa, Pierre] Univ Paris Denis Diderot, Hop Beaujon, Dept Pathol, Paris, France. [Lehert, Philippe] Univ Melbourne, Dept Psychiat, Melbourne, Vic, Australia. [Lehert, Philippe] Univ Louvain UCL, Fac Econ, Louvain, Belgium. [Serfaty, Lawrence] Univ Paris 06, Hop St Antoine, Paris, France. [Romero-Gomez, Manuel] Hosp Univ Valme, Unit Clin Management Digest Dis, Seville, Spain. [Romero-Gomez, Manuel] Hosp Univ Valme, CIBERehd, Seville, Spain. [Boursier, Jerome] Univ Hosp, Hepatol Dept, Angers, France. [Boursier, Jerome] LUNAM Univ, Angers, France. [Abdelmalek, Manal] Duke Univ, Durham, NC USA. [Caldwell, Steve] Univ Virginia, Div Gastroenterol & Hepatol, Charlottesville, VA USA. [Drenth, Joost P. H.] Radboud Univ Nijmegen, Med Ctr, Dept Gastroenterol & Hepatol, NL-6525 ED Nijmegen, Netherlands. [Anstee, Quentin M.] Newcastle Univ, Fac Med Sci, Inst Cellular Med, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England. [Hum, Dean; Hanf, Remy; Roudot, Alice; Megnien, Sophie] Genfit SA, Loos, France. [Staels, Bart] Univ Lille, INSERM, UMR1011, Inst Pasteur Lille,European Genom Inst Diabet, Lille, France. [Sanyal, Arun] Virginia Commonwealth Univ, Richmond, VA USA. RP Ratziu, V (reprint author), Univ Paris 06, Hosp Pitie Salpetriere, 47-83 Bd Hop, F-75013 Paris, France. EM vlad.ratziu@upmc.fr RI Staels, Bart/N-9497-2016; Francque, Sven/E-4526-2017 OI Staels, Bart/0000-0002-3784-1503; Francque, Sven/0000-0002-7527-4714 NR 36 TC 33 Z9 33 U1 11 U2 15 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0016-5085 EI 1528-0012 J9 GASTROENTEROLOGY JI Gastroenterology PD MAY PY 2016 VL 150 IS 5 BP 1147 EP + DI 10.1053/j.gastro.2016.01.038 PG 18 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA DJ8QM UT WOS:000374477200029 PM 26874076 ER PT J AU Bauer, CMC Greer, DM Kram, JJF Kamelle, SA AF Bauer, Callie M. Cox Greer, Danielle M. Kram, Jessica J. F. Kamelle, Scott A. TI Tumor diameter as a predictor of lymphatic dissemination in endometrioid endometrial cancer SO GYNECOLOGIC ONCOLOGY LA English DT Article DE Endometrial cancer; Endometrioid; Lymphatic dissemination; Myometrial invasion; Nodal metastatic disease; Tumor cell grade; Tumor diameter ID GYNECOLOGIC-ONCOLOGY-GROUP; NODAL METASTASIS; RISK; LYMPHADENECTOMY; CARCINOMA; CLASSIFICATION; HYSTERECTOMY; INVASION; TRIAL; SIZE AB Objectives. To assess the utility of tumor diameter (TD) for predicting lymphatic dissemination (LD) and determining need for lymphadenectomy following diagnosis of endometrioid endometrial cancer. Methods. Patients diagnosed with stage I-III endometrioid endometrial cancer during 2003-2013 who underwent complete lymphadenectomy during hysterectomy were studied. Intraoperative predictors of LD included TD, grade, myometrial invasion (MI), age, body mass index, and race/ethnicity. Candidate logistic regression models of LD were evaluated for model fit and predictive power. Results. Of 737 cancer patients, 68 (9.2%) were node-positive. Single-variable models with only continuous TD (c-statistic 0.77, 95% CI 0.71-0.83) and dichotomous TD with 50-mm cut-off (TD50; c-statistic 0.73, 95% CI 0.67-0.78) were significantly more predictive than with the standard 20-mm cut-off (c-statistic 0.56, 95% CI 0.53-0.59). Overall, the most important LD predictors were TD50 and MI3rds (three-category form). The best candidate model (c-statistic 0.84, 95% CI 0.80-0.88) suggested odds of LD were five times greater for TD >50 mm than <= 50 mm (OR 4.91, 95% CI 2.73-8.82) and six and ten times greater for MI >33% to <= 66% (OR, 5.70; 95% CI, 2.25-14.5) and >66% (OR 10.2, 95% CI 4.11-25.4), respectively, than <= 33%. Best-model false-negative (0%) and positive (57.2%) rates demonstrated marked improvement over traditional risk-stratification false-negative (1.5%) and positive (762%) rates (c-statistic 0.77, 95% CI 0.72-0.82). Conclusions. Tumor diameter is an important predictor of LD. Our risk model, containing modified forms of MI and TD, yielded a lower false-negative rate and can significantly decrease the number of lymphadenectomies performed on low-risk women. Published by Elsevier Inc. C1 [Bauer, Callie M. Cox] Aurora Hlth Care, Aurora Sinai Med Ctr, Dept Obstet & Gynecol, Milwaukee, WI USA. [Greer, Danielle M.; Kram, Jessica J. F.] Aurora Hlth Care, Aurora Sinai Med Ctr, Ctr Urban Populat, Aurora UW Med Grp, Milwaukee, WI USA. [Kamelle, Scott A.] Aurora Hlth Care, Aurora St Lukes Med Ctr, Dept Oncol, Milwaukee, WI USA. RP Bauer, CMC (reprint author), Brooke Army Med Ctr, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM callie.cox.bauer@gmail.com OI Cox Bauer, Callie /0000-0002-9302-0881; Kram, Jessica/0000-0001-9831-7353 NR 25 TC 1 Z9 1 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 EI 1095-6859 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD MAY PY 2016 VL 141 IS 2 BP 199 EP 205 DI 10.1016/j.ygyno.2016.02.017 PG 7 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA DL0YJ UT WOS:000375358200004 ER PT J AU Olwenyi, OA Naluyima, P Cham, F Quinn, TC Serwadda, D Sewankambo, NK Gray, RH Sandberg, JK Michael, NL Wabwire-Mangen, F Robb, ML Eller, MA AF Olwenyi, Omalla A. Naluyima, Prossy Cham, Fatim Quinn, Thomas C. Serwadda, David Sewankambo, Nelson K. Gray, Ronald H. Sandberg, Johan K. Michael, Nelson L. Wabwire-Mangen, Fred Robb, Merlin L. Eller, Michael A. TI Differential Associations of Interleukin 6 and Intestinal Fatty Acid-Binding Protein With Progressive Untreated HIV-1 Infection in Rakai, Uganda SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE HIV-1; AIDS; immune activation; inflammation; IL-6; IFABP ID C-REACTIVE PROTEIN; IMMUNODEFICIENCY-VIRUS TYPE-1; T-CELL DEPLETION; SYSTEMIC IMMUNE ACTIVATION; DISEASE PROGRESSION; MICROBIAL TRANSLOCATION; GASTROINTESTINAL-TRACT; VIRAL LOAD; ANTIRETROVIRAL THERAPY; PREDICT MORTALITY AB The significance of HIV-associated immune activation and microbial translocation in Sub-Saharan African population remains poorly defined. We assessed biomarkers of inflammation, microbial translocation, and cellular activation and found most factors elevated in Ugandan HIV-1 seroconverters compared with community-matched controls. In contrast to previous findings in Western cohorts, C-reactive protein, neopterin, and intestinal fatty acid binding protein were not elevated. Higher T-cell activation and IL-6 were associated with faster disease progression. Surprisingly, intestinal fatty acid binding protein, indicative of enterocyte turnover, was higher in slow than in fast progressors. These data suggest differential relationships among biomarkers of intestinal barrier integrity and innate immune activation between developed countries and Sub-Saharan Africa. C1 [Olwenyi, Omalla A.; Naluyima, Prossy; Cham, Fatim; Wabwire-Mangen, Fred] Makerere Univ Walter Reed Project, Kampala, Uganda. [Naluyima, Prossy; Sandberg, Johan K.] Karolinska Univ, Huddinge Hosp, Karolinska Inst, Ctr Infect Med,Dept Med, Stockholm, Sweden. [Cham, Fatim] Henry M Jackson Fdn Adv of Mil Med, Bethesda, MD USA. [Quinn, Thomas C.] NIAID, Immunoregulat Lab, Div Intramural Res, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA. [Quinn, Thomas C.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. [Serwadda, David; Wabwire-Mangen, Fred] Makerere Univ, Coll Hlth Sci, Sch Publ Hlth, Kampala, Uganda. [Serwadda, David; Sewankambo, Nelson K.] Uganda Virus Res Inst, Rakai Hlth Sci Program, Entebbe, Uganda. [Sewankambo, Nelson K.] Makerere Univ, Coll Hlth Sci, Fac Med, Kampala, Uganda. [Gray, Ronald H.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA. [Michael, Nelson L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. RP Eller, MA (reprint author), Walter Reed Army Inst, HJF, US Mil HIV Res Program MHRP, 503 Robert Grant Ave,1N11, Silver Spring, MD 20910 USA. EM meller@hivresearch.org FU Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-11-2-0174]; U.S. Army Medical Research and Materiel Command [W81XWH-11-2-0174] FX Supported by a cooperative agreement (W81XWH-11-2-0174) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Army Medical Research and Materiel Command. NR 46 TC 0 Z9 0 U1 2 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1525-4135 EI 1077-9450 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD MAY 1 PY 2016 VL 72 IS 1 BP 15 EP 20 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA DK6WY UT WOS:000375067600012 PM 26630672 ER PT J AU Yehuda, R Hoge, CW AF Yehuda, Rachel Hoge, Charles W. TI The Meaning of Evidence-Based Treatments for Veterans With Posttraumatic Stress Disorder SO JAMA PSYCHIATRY LA English DT Editorial Material ID PTSD C1 [Yehuda, Rachel] James J Peters Vet Affairs Med Ctr, Dept Psychiat, 130 W Kingsbridge Rd, Bronx, NY 10468 USA. [Yehuda, Rachel] Icahn Sch Med Mt Sinai, New York, NY 10029 USA. [Hoge, Charles W.] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Yehuda, R (reprint author), James J Peters Vet Affairs Med Ctr, Dept Psychiat, 130 W Kingsbridge Rd, Bronx, NY 10468 USA. EM rachel.yehuda@mssm.edu NR 7 TC 5 Z9 5 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-622X EI 2168-6238 J9 JAMA PSYCHIAT JI JAMA Psychiatry PD MAY PY 2016 VL 73 IS 5 BP 433 EP 434 DI 10.1001/jamapsychiatry.2015.2878 PG 2 WC Psychiatry SC Psychiatry GA DL2KD UT WOS:000375462600002 PM 26886229 ER PT J AU O'Brien, CP Jenness, GR Dong, H Vlachos, DG Lee, IC AF O'Brien, Casey P. Jenness, Glen R. Dong, Hong Vlachos, Dionisios G. Lee, Ivan C. TI Deactivation of Pt/Al2O3 during propane oxidation at low temperatures: Kinetic regimes and platinum oxide formation SO JOURNAL OF CATALYSIS LA English DT Article DE Kinetic regimes; Oxidation; Platinum oxide; Infrared spectroscopy ID PHASE OXYGEN-ATOMS; IN-SITU OXIDATION; CO OXIDATION; CHEMISORBED OXYGEN; CARBON-MONOXIDE; CATALYTIC-OXIDATION; SUBSURFACE OXYGEN; RATE OSCILLATIONS; DEEP OXIDATION; PARTICLE-SIZE AB The kinetics of propane oxidation over Pt/Al2O3 are investigated in this work as a function of O-2/C3H8 ratio in the 150-300 degrees C temperature range. At high O-2/C3H8 ratios, the platinum nanoparticles are saturated with oxygen and the reaction rate is zero-order with respect to the oxygen partial pressures in this regime. As the oxygen coverage decreases with decreasing O-2/C3H8 ratio, the reaction rate increases and the reaction order changes from zero-order to negative-order in the oxygen partial pressure. The reaction rate is controlled to a large extent by the oxygen coverage on the platinum nanoparticles. However, at lower temperatures and higher oxygen pressures there is a slow deactivation of the catalyst that cannot be explained by a slow change in the oxygen coverage. Diffuse reflectance infrared Fourier-transform spectroscopy (DRIFTS) of adsorbed CO was performed to track the evolution of the nanoparticle structure over the course of the propane oxidation reaction and to determine whether the slow deactivation was caused by reconstruction of the platinum nanoparticles. We found that the platinum nanoparticles are significantly reconstructed during the course of the reaction, including the formation of a platinum oxide (PtO) which has a characteristic CO-DRIFTS band at 2123 cm(-1). The extent of PtO formation decreases with increasing temperature and, as a result, deactivation of the catalyst is less severe at higher temperatures. Unexpectedly, increasing the oxygen partial pressure resulted in less PtO formation. We believe that a different platinum oxide phase (e.g. PtO2 or Pt3O4) is formed at higher oxygen pressures, which is reduced to metallic platinum during CO exposure at 25 degrees C, and therefore is not detectable by CO DRIFTS. These results are unique because they show how the nanoparticle structure evolves over many hours of propane oxidation, and how the temperature and oxygen pressure influence the reconstruction of the nanoparticles, which has implications for a wide range of reactions not limited to propane oxidation. Published by Elsevier Inc. C1 [O'Brien, Casey P.; Dong, Hong; Lee, Ivan C.] US Army Res Lab, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Jenness, Glen R.; Vlachos, Dionisios G.] Univ Delaware, Catalysis Ctr Energy Innovat, Dept Chem & Biomol Engn, Newark, DE 19716 USA. [Jenness, Glen R.; Vlachos, Dionisios G.] Univ Delaware, Ctr Catalyt Sci & Technol, Newark, DE 19716 USA. RP Lee, IC (reprint author), US Army Res Lab, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM ivan.c.lee2.civ@mail.mil OI Vlachos, Dionisios/0000-0002-6795-8403 FU U.S. Army Research Laboratory [W911NF-12-2-0019, W911NF-10-0047]; Catalysis Center for Energy Innovation, an Energy Frontier Research Center - U.S. Dept. of Energy, Office of Science, Office of Basic Energy Sciences [DE-SC0001004] FX Research was sponsored by the U.S. Army Research Laboratory and was accomplished under Cooperative Agreement Numbers W911NF-12-2-0019 and W911NF-10-0047. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. The DFT calculations were conducted at UD and were supported as part of the Catalysis Center for Energy Innovation, an Energy Frontier Research Center funded by the U.S. Dept. of Energy, Office of Science, Office of Basic Energy Sciences under Award Number DE-SC0001004. NR 60 TC 0 Z9 0 U1 14 U2 42 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0021-9517 EI 1090-2694 J9 J CATAL JI J. Catal. PD MAY PY 2016 VL 337 BP 122 EP 132 DI 10.1016/j.jcat.2016.02.012 PG 11 WC Chemistry, Physical; Engineering, Chemical SC Chemistry; Engineering GA DK4WG UT WOS:000374920400014 ER PT J AU Wu, YQ Lu, Z Emdadi, L Oh, SC Wang, J Lei, Y Chen, HY Tran, DT Lee, IC Liu, DX AF Wu, Yiqing Lu, Zheng Emdadi, Laleh Oh, Su Cheun Wang, Jing Lei, Yu Chen, Huiyong Tran, Dat T. Lee, Ivan C. Liu, Dongxia TI Tuning external surface of unit-cell thick pillared MFI and MWW zeolites by atomic layer deposition and its consequences on acid-catalyzed reactions SO JOURNAL OF CATALYSIS LA English DT Article DE Unit-cell thick zeolite; Hierarchical zeolite; Acidity Atomic layer deposition (ALD); Bronsted acid sites; Methane aromatization ID MOLECULAR-SIEVE; INTERCALATION CHEMISTRY; SPATIAL-DISTRIBUTION; LAMELLAR ZEOLITE; DIMETHYL ETHER; SITES; NANOSHEETS; PRECURSOR; BEHAVIOR; ALUMINUM AB The pillared MWW (PMWW or MCM-36) and pillared MFI (PMFI) zeolites are 2-dimensional (2D) catalytically active materials made by pillaring of layered MCM-22(P) and multilamellar MFI precursors, respectively. The single- or near single-unit-cell thick 2D microporous layers in PMWW and PMFI expose comparable number of external surface acid sites (i.e., acid sites enclosed in mesopores between zeolitic layers) to those in micropores, which become important or dominant contributor to the catalytic properties. Although the acidity and catalytic activities of PMWW and PMFI have been studied, modification of their external surfaces and its implications on catalytic reactions are not available. In the present study, we report the tailoring of external surfaces of PMWW and PMFI zeolites by atomic layer deposition (ALD) of silicon (ALD-Si) and aluminum (ALD-Al), respectively. The textural, acidic and catalytic properties of the ALD modified pillared zeolites were investigated using a variety of characterization methods. ALD-Al and ALD-Si modifications kept micropore almost intact, but resulted in significant reduction in mesopore volume and considerable changes in external surface composition and acidity. The catalytic tests showed that intrinsic catalytic behavior of Bronsted acid sites in ALD modified pillared zeolites was similar to their parent counterparts. In diffusion constrained parallel reactions, ALD of Al- or Si-species altered catalyst selectivity. In addition, ALD of Si-species on PMFI zeolite deactivated surface active sites, which resulted in improved catalytic activity in direct methane aromatization reactions under optimal ALD cycles. The study exemplified for the first time that ALD is an effective tool for tuning the surface properties of 2D unit-cell thick zeolites. (C) 2016 Elsevier Inc. All rights reserved. C1 [Wu, Yiqing; Emdadi, Laleh; Oh, Su Cheun; Liu, Dongxia] Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA. [Lu, Zheng; Lei, Yu] Univ Alabama, Dept Chem & Mat Engn, Huntsville, AL 35899 USA. [Wang, Jing; Chen, Huiyong] NW Univ Xian, Sch Chem Engn, Xian 710069, Shaanxi, Peoples R China. [Tran, Dat T.; Lee, Ivan C.] US Army Res Lab, RDRL SED E, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RP Liu, DX (reprint author), Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA. EM liud@umd.edu FU American Chemical Society Petroleum Research Fund (ACS-PRF) [52089-DNI5]; National Science Foundation [NSF-CBET 1264599, 1351384]; Maryland NanoCenter and its NispLab; NSF as a MRSEC Shared Experimental Facility; University of Maryland Energy Research Center (UMERC) FX The authors gratefully acknowledge financial support from the American Chemical Society Petroleum Research Fund (ACS-PRF, 52089-DNI5) and National Science Foundation (NSF-CBET 1264599 and 1351384). We acknowledge the support of Maryland NanoCenter and its NispLab. The NispLab is supported in part by the NSF as a MRSEC Shared Experimental Facility. Yiqing Wu thanks for the Hulka Energy Research Fellowship from University of Maryland Energy Research Center (UMERC) to support his research. NR 66 TC 3 Z9 3 U1 31 U2 63 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0021-9517 EI 1090-2694 J9 J CATAL JI J. Catal. PD MAY PY 2016 VL 337 BP 177 EP 187 DI 10.1016/j.jcat.2016.01.031 PG 11 WC Chemistry, Physical; Engineering, Chemical SC Chemistry; Engineering GA DK4WG UT WOS:000374920400020 ER PT J AU Stromdahl, EY Nadolny, RM Gibbons, JA Auckland, LD Vince, MA Elkins, CE Murphy, MP Hickling, GJ Eshoo, MW Carolan, HE Crowder, CD Pilgard, MA Hamer, SA AF Stromdahl, Ellen Y. Nadolny, Robyn M. Gibbons, Jennifer A. Auckland, Lisa D. Vince, Mary A. Elkins, Chad E. Murphy, Michael P. Hickling, Graham J. Eshoo, Mark W. Carolan, Heather E. Crowder, Chris D. Pilgard, Mark A. Hamer, Sarah A. TI Borrelia burgdorferi Not Confirmed in Human-Biting Amblyomma americanum Ticks from the Southeastern United States (vol 53, pg 1698, 2015) SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Correction C1 [Stromdahl, Ellen Y.; Nadolny, Robyn M.; Vince, Mary A.; Elkins, Chad E.; Murphy, Michael P.] US Army Publ Hlth Command, Aberdeen Proving Ground, MD USA. [Nadolny, Robyn M.] Old Dominion Univ, Dept Biol Sci, Norfolk, VA 23529 USA. [Gibbons, Jennifer A.] US Army Edgewood Chem & Biol Ctr, Aberdeen Proving Ground, MD USA. [Gibbons, Jennifer A.] Sci & Technol Corp, Hampton, VA 23666 USA. [Auckland, Lisa D.; Hamer, Sarah A.] Texas A&M Univ, Dept Vet Integrat Biosci, College Stn, TX USA. [Hickling, Graham J.] Univ Tennessee, Inst Agr, Ctr Wildlife Hlth, Knoxville, TN 37901 USA. [Eshoo, Mark W.; Carolan, Heather E.; Crowder, Chris D.] Ibis Biosci, Carlsbad, CA USA. [Pilgard, Mark A.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO USA. RP Stromdahl, EY (reprint author), US Army Publ Hlth Command, Aberdeen Proving Ground, MD USA. NR 1 TC 0 Z9 0 U1 3 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 EI 1098-660X J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD MAY PY 2016 VL 54 IS 5 BP 1406 EP 1406 DI 10.1128/JCM.00527-16 PG 1 WC Microbiology SC Microbiology GA DK5JH UT WOS:000374955700042 PM 27114565 ER PT J AU Gulgec, NS Ergan, S Akinci, B Kelly, CJ AF Gulgec, Nur Sila Ergan, Semiha Akinci, Burcu Kelly, Christopher J. TI Integrated Information Repository for Risk Assessment of Embankment Dams: Requirements Identification for Evaluating the Risk of Internal Erosion SO JOURNAL OF COMPUTING IN CIVIL ENGINEERING LA English DT Article DE Risk assessment; Internal erosion; Information requirement; Dams; Information modeling ID MODEL AB Dams are continuing to age and deteriorate that affect the service life of the dams in the U.S. Risk assessment is required to understand the behavior of dams and to prioritize the remedial actions and maintenance, and yet it is quite challenging to do risk assessment since it requires extensive current and historical data from in situ instrumentation on dams and detailed design, construction, and operation information. Currently, the required data for risk assessment resides in various paper-based and digital documents that hinder the capabilities of risk assessors to gather, analyze, and visualize the data flexibly from various engineering perspectives such as geotechnical, hydrologic, geologic, and structural. As a result, getting a holistic view of a dam's current condition and its behavior over time becomes a time and resource intensive task. There is a need for an integrated shared knowledge repository for dams to streamline the risk assessment process. The research described in this paper provides requirements for developing such a shared knowledge repository for risk assessment of embankment dams that would support the information needs of various engineering domains and the means and methods for integrated assessment, visualization, and data analytics to understand the risk of internal erosion. (C) 2015 American Society of Civil Engineers. C1 [Gulgec, Nur Sila] Lehigh Univ, Dept Civil & Environm Engn, 13 East Packer Ave, Bethlehem, PA 18015 USA. [Ergan, Semiha] NYU, Dept Civil & Urban Engn, MetroTech Ctr 6, Polytech Sch Engn, Brooklyn, NY 11201 USA. [Akinci, Burcu] Carnegie Mellon Univ, Dept Civil & Environm Engn, 5000 Forbes Ave, Pittsburgh, PA 15213 USA. [Kelly, Christopher J.] US Army Corps Engineers, Risk Management Ctr, 1000 Liberty Ave, Pittsburgh, PA 15222 USA. RP Gulgec, NS (reprint author), Lehigh Univ, Dept Civil & Environm Engn, 13 East Packer Ave, Bethlehem, PA 18015 USA. EM nsg214@lehigh.edu; semiha@nyu.edu; bakinci@cmu.edu; christopher.j.kelly2@usace.army.mil NR 23 TC 0 Z9 0 U1 6 U2 7 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0887-3801 EI 1943-5487 J9 J COMPUT CIVIL ENG JI J. Comput. Civil. Eng. PD MAY PY 2016 VL 30 IS 3 AR 04015038 DI 10.1061/(ASCE)CP.1943-5487.0000509 PG 12 WC Computer Science, Interdisciplinary Applications; Engineering, Civil SC Computer Science; Engineering GA DK4DU UT WOS:000374868100012 ER PT J AU Cerco, CF AF Cerco, Carl F. TI Conowingo Reservoir Sedimentation and Chesapeake Bay: State of the Science SO JOURNAL OF ENVIRONMENTAL QUALITY LA English DT Article ID RIVER; MANAGEMENT; USA AB The Conowingo Reservoir is situated on the Susquehanna River, immediately upstream of Chesapeake Bay, the largest estuary in the United States. Sedimentation in the reservoir provides an unintended benefit to the bay by preventing sediments, organic matter, and nutrients from entering the bay. The sediment storage capacity of the reservoir is nearly exhausted, however, and the resulting increase in loading of sediments and associated materials is a potential threat to Chesapeake Bay water quality. In response to this threat, the Lower Susquehanna River Watershed Assessment was conducted. The assessment indicates the reservoir is in a state of "dynamic equilibrium" in which sediment loads from the upstream watershed to the reservoir are balanced by sediments leaving the reservoir. Increased sediment loads are not a threat to bay water quality. Increased loads of associated organic matter and nutrients are, however, detrimental. Bottom-water dissolved oxygen declines of 0.1 to 0.2 g m(-3) are projected as a result of organic matter oxidation and enhanced eutrophication. The decline is small relative to normal variations but results in violations of standards enforced in a recently enacted total maximum daily load. Enhanced reductions in nutrient loads from the watershed are recommended to offset the decline in water quality caused by diminished retention in the reservoir. The assessment exposed several knowledge gaps that require additional investigation, including the potential for increased loading at flows below the threshold for reservoir scour and the nature and reactivity of organic matter and nutrients scoured from the reservoir bottom. C1 [Cerco, Carl F.] US Army, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. RP Cerco, CF (reprint author), US Army, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM carl.f.cerco@usace.army.mil NR 37 TC 0 Z9 0 U1 4 U2 11 PU AMER SOC AGRONOMY PI MADISON PA 677 S SEGOE RD, MADISON, WI 53711 USA SN 0047-2425 EI 1537-2537 J9 J ENVIRON QUAL JI J. Environ. Qual. PD MAY-JUN PY 2016 VL 45 IS 3 BP 882 EP 886 DI 10.2134/jeq2015.05.0230 PG 5 WC Environmental Sciences SC Environmental Sciences & Ecology GA DK8EJ UT WOS:000375159700016 PM 27136154 ER PT J AU Linker, LC Batiuk, RA Cerco, CF Shenk, GW Tian, R Wang, P Yactayo, G AF Linker, Lewis C. Batiuk, Richard A. Cerco, Carl F. Shenk, Gary W. Tian, Richard Wang, Ping Yactayo, Guido TI Influence of Reservoir Infill on Coastal Deep Water Hypoxia SO JOURNAL OF ENVIRONMENTAL QUALITY LA English DT Article ID CHESAPEAKE BAY; SEDIMENT LOAD; EUTROPHICATION; MODEL; TRENDS; BASIN AB Ecological restoration of the Chesapeake through the Chesapeake Bay total maximum daily load (TMDL) requires the reduction of nitrogen, phosphorus, and sediment loads in the Chesapeake watershed because of the tidal water quality impairments and damage to living resources they cause. Within the Chesapeake watershed, the Conowingo Reservoir has been filling in with sediment for almost a century and is now in a state of near-full capacity called dynamic equilibrium. The development of the Chesapeake TMDL in 2010 was with the assumption that the Conowingo Reservoir was still effectively trapping sediment and nutrients. This is now known not to be the case. In a TMDL, pollutant loads beyond the TMDL allocation, which are brought about by growth or other conditions, must be offset. Using the analysis tools of the Chesapeake TMDL for assessing the degree of water quality standard attainment, the estimated nutrient and sediment loads from a simulated dynamic equilibrium infill condition of the Conowingo Reservoir were determined. The influence on Chesapeake water quality by a large storm and scour event of January 1996 on the Susquehanna River was estimated, and the same storm and scour events were also evaluated in the more critical living resource period of June. An analysis was also made on the estimated influence of more moderate high flow events. The infill of the Conowingo reservoir had estimated impairments of water quality, primarily on deep-water and deep-channel dissolved oxygen, because of increased discharge and transport of organic and particulate inorganic nutrients from the Conowingo Reservoir. C1 [Linker, Lewis C.; Batiuk, Richard A.; Shenk, Gary W.] US EPA, Chesapeake Bay Program Off, 410 Severn Ave,Suite 109, Annapolis, MD 21403 USA. [Cerco, Carl F.] US Army, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. [Tian, Richard; Yactayo, Guido] Univ Maryland, Ctr Environm Sci, Chesapeake Bay Program Off, 410 Severn Ave,Suite 109, Annapolis, MD 21403 USA. [Wang, Ping] Virginia Inst Marine Sci, Chesapeake Bay Off, 410 Severn Ave, Annapolis, MD 21403 USA. RP Linker, LC (reprint author), US EPA, Chesapeake Bay Program Off, 410 Severn Ave,Suite 109, Annapolis, MD 21403 USA. EM LLinker@chesapeakebay.net NR 38 TC 2 Z9 2 U1 3 U2 10 PU AMER SOC AGRONOMY PI MADISON PA 677 S SEGOE RD, MADISON, WI 53711 USA SN 0047-2425 EI 1537-2537 J9 J ENVIRON QUAL JI J. Environ. Qual. PD MAY-JUN PY 2016 VL 45 IS 3 BP 887 EP 893 DI 10.2134/jeq2014.11.0461 PG 7 WC Environmental Sciences SC Environmental Sciences & Ecology GA DK8EJ UT WOS:000375159700017 PM 27136155 ER PT J AU Cerco, CF Noel, MR AF Cerco, Carl F. Noel, Mark R. TI Impact of Reservoir Sediment Scour on Water Quality in a Downstream Estuary SO JOURNAL OF ENVIRONMENTAL QUALITY LA English DT Article ID CHESAPEAKE BAY; MODEL; SIMULATION; TRANSPORT; BUDGET; RECORD; USA; CD; PB AB The Conowingo Reservoir is situated at the lower terminus of the Susquehanna River watershed, immediately above Chesapeake Bay. Since construction, the reservoir has been filling with sediment to the point where storage capacity is nearly exhausted. The potential for release of accumulated sediments, organic matter, and nutrients, especially through the action of storm scour, causes concern for water quality in Chesapeake Bay. We used hydrodynamic and eutrophication models to examine the effects of watershed loads and scour loads on bay water quality under total maximum daily load conditions. Results indicate that increased suspended solids loads are not a threat to bay water quality. For most conditions, solids scoured from the reservoir settle out before the season during which light attenuation is critical. The organic matter and nutrients associated with the solids are, however, detrimental. This material settles to the estuary bottom and is mineralized in bed sediments. Carbon diagenesis spurs oxygen consumption in bottom sediments and in the water column via release of chemical oxygen demand. The nutrients are recycled to the water column and stimulate algal production. As a result of a scour event, bottom-water dissolved oxygen declines up to 0.2 g m(-3), although the decline is 0.1 g m(-3) or less when averaged over the summer season. Surface chlorophyll increases 0.1 to 0.3 mg m(-3) during the summer growing season. C1 [Cerco, Carl F.; Noel, Mark R.] US Army, Environm Lab, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. RP Cerco, CF (reprint author), US Army, Environm Lab, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM carl.f.cerco@usace.army.mil NR 39 TC 2 Z9 2 U1 9 U2 17 PU AMER SOC AGRONOMY PI MADISON PA 677 S SEGOE RD, MADISON, WI 53711 USA SN 0047-2425 EI 1537-2537 J9 J ENVIRON QUAL JI J. Environ. Qual. PD MAY-JUN PY 2016 VL 45 IS 3 BP 894 EP 905 DI 10.2134/jeq2014.10.0425 PG 12 WC Environmental Sciences SC Environmental Sciences & Ecology GA DK8EJ UT WOS:000375159700018 PM 27136156 ER PT J AU Hamele, M Stockmann, C Cirulis, M Riva-Cambrin, J Metzger, R Bennett, TD Bratton, SL AF Hamele, Mitchell Stockmann, Chris Cirulis, Meghan Riva-Cambrin, Jay Metzger, Ryan Bennett, Tellen D. Bratton, Susan L. TI Ventilator-Associated Pneumonia in Pediatric Traumatic Brain Injury SO JOURNAL OF NEUROTRAUMA LA English DT Article DE pediatric; pneumonia; traumatic brain injury ID INTENSIVE-CARE-UNIT; RISK-FACTORS; NOSOCOMIAL PNEUMONIA; ACQUIRED PNEUMONIA; CLINICAL-TRIAL; SAUDI-ARABIA; CHILDREN; HYPOTHERMIA; SURVEILLANCE; INFECTION AB Ventilator-associated pneumonia (VAP) is a common occurrence among intubated pediatric traumatic brain injury (TBI) patients. However, little is known about the epidemiology, risk factors, and microbiology of VAP in pediatric TBI. We reviewed a cohort of 119 pediatric moderate-to-severe TBI patients and identified 42 with VAP by positive protected bronchial brush specimens. Location of intubation, severity of injury, and antibiotic administration within 2 days after injury were not associated with VAP. Most treatments for elevated intracranial pressure were associated with increased risk of VAP; however, in a multi-variable analysis barbiturate coma (hazard ratio [HR], 3.2; 95% confidence interval [CI] 1.4-7.3), neuromuscular blockade (NMBA; HR, 3.4; 95% CI 1.6-7.3), and use of a cooling blanket for euthermia (HR 2.4; 95% CI 1.1-5.5) remained independently associated with VAP. Most VAP (55%) occurred prior to hospital Day 4 and only 7% developed VAP after Day 7. Methicillin-sensitive Staphylococcus aureus (34%), Haemophilus influenzae (22%), and Streptococcus pneumoniae (15%) were the most common organisms, comprising 71% of isolated pathogens (36% of infections were polymicrobial). Patients with VAP had significantly longer intensive care unit and hospital stays, as well as increased risk of chronic care needs after discharge, but not mortality. VAP is a common occurrence in pediatric TBI patients, and early empiric therapy for patients requiring barbiturate infusion, NMBA, or use of a cooling blanket could mitigate morbidity. C1 [Hamele, Mitchell; Stockmann, Chris; Cirulis, Meghan; Bratton, Susan L.] Univ Utah, Sch Med, Dept Pediat, Salt Lake City, UT USA. [Riva-Cambrin, Jay] Univ Utah, Sch Med, Dept Neurosurg, Salt Lake City, UT USA. [Metzger, Ryan] Univ Utah, Sch Med, Div Pediat Surg, Salt Lake City, UT USA. [Bennett, Tellen D.] Univ Colorado, Sch Med, Pediat Crit Care, Aurora, CO USA. RP Hamele, M (reprint author), Univ Utah, Dept Pediat, US Army Med Corps, 295 Chipeta Way,POB 581289, Salt Lake City, UT 84158 USA. EM mitchell.hamele@hsc.utah.edu OI Bennett, Tellen/0000-0003-1483-4236 FU NICHD NIH HHS [K23 HD074620] NR 34 TC 1 Z9 1 U1 2 U2 2 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD MAY 1 PY 2016 VL 33 IS 9 BP 832 EP 839 DI 10.1089/neu.2015.4004 PG 8 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA DK7SA UT WOS:000375124800005 PM 26203702 ER PT J AU Camacho, M Dunn, B Torre, C Sasaki, J Gonzales, R Liu, SYC Chan, DK Certal, V Cable, BB AF Camacho, Macario Dunn, Brandyn Torre, Carlos Sasaki, Jodie Gonzales, Raymond Liu, Stanley Yung-Chuan Chan, Dylan K. Certal, Victor Cable, Benjamin B. TI Supraglottoplasty for laryngomalacia with obstructive sleep apnea: A systematic review and meta-analysis SO LARYNGOSCOPE LA English DT Review DE Obstructive sleep apnea; supraglottoplasty; laryngomalacia; systematic review; meta-analysis ID SURGICAL-TREATMENT; ASSISTED SUPRAGLOTTOPLASTY; APNEA/HYPOPNEA SYNDROME; OCCULT LARYNGOMALACIA; RISK-FACTORS; FOLLOW-UP; OUTCOMES; CHILDREN; INFANTS; ENDOSCOPY AB Objectives/HypothesisTo determine if apnea-hypopnea index (AHI) and lowest oxygen saturation (LSAT) improve following isolated supraglottoplasty for laryngomalacia with obstructive sleep apnea (OSA) in children. Study DesignSystematic review and meta-analysis. MethodsNine databases, including PubMed/MEDLINE, were searched through September 30, 2015. ResultsA total of 517 studies were screened; 57 were reviewed; and 13 met criteria. One hundred thirty-eight patients were included (age range: 1 month-12.6 years). Sixty-four patients had sleep exclusive laryngomalacia, and in these patients: 1) AHI decreased from a mean (M) standard deviation (SD) of 14.0 +/- 16.5 (95% confidence interval [CI] 10.0, 18.0) to 3.3 +/- 4.0 (95% CI 2.4, 4.4) events/hour (relative reduction: 76.4% [95% CI 53.6, 106.4]); 2) LSAT improved from a M +/- SD of 84.8 +/- 8.4% (95% CI 82.8, 86.8) to 87.6 +/- 4.4% (95% CI 86.6, 88.8); 3) standardized mean differences (SMD) demonstrated a small effect for LSAT and a large effect for AHI; and 4) cure (AHI < 1 event/hour) was 10.5% (19 patients with individual data). Seventy-four patients had congenital laryngomalacia, and in these patients: 1) AHI decreased from a M +/- SD of 20.4 +/- 23.9 (95% CI 12.8, 28.0) to 4.0 +/- 4.5 (95% CI 2.6, 5.4) events/hour (relative reduction: 80.4% [95% CI 46.6, 107.4]); 2) LSAT improved from a M +/- SD of 74.5 +/- 11.9% (95% CI 70.9, 78.1) to 88.4 +/- 6.6% (95% CI 86.4, 90.4); 3) SMD demonstrated a large effect for both AHI and LSAT; and 4) cure was 26.5% (38 patients with individual data). ConclusionSupraglottoplasty has improved AHI and LSAT in children with OSA and either sleep exclusive laryngomalacia or congenital laryngomalacia; however, the majority of them are not cured. Laryngoscope, 126:1246-1255, 2016 C1 [Camacho, Macario; Cable, Benjamin B.] Tripler Army Med Ctr, Div Sleep Surg & Med, Otolaryngol Head & Neck Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. [Dunn, Brandyn; Sasaki, Jodie] Univ Hawaii, John A Burns Sch Med, Honolulu, HI 96822 USA. [Camacho, Macario] Stanford Hosp & Clin, Sleep Med Div, Dept Psychiat & Behav Sci, San Francisco, CA USA. [Torre, Carlos; Liu, Stanley Yung-Chuan] Stanford Hosp & Clin, Sleep Med Div, Dept Otolaryngol Head & Neck Surg, San Francisco, CA USA. [Chan, Dylan K.] Univ Calif San Francisco, Div Pediat Otolaryngol, Dept Otolaryngol Head & Neck Surg, San Francisco, CA 94143 USA. [Gonzales, Raymond] Uniformed Serv Univ Hlth Sci, Sch Med, Bethesda, MD 20814 USA. [Certal, Victor] Univ Porto, Sleep Med Ctr, Dept Otorhinolaryngol, Hosp CUF, Rua Campo Alegre 823, P-4100 Oporto, Portugal. [Certal, Victor] Univ Porto, CINTESIS Ctr Res Hlth Technol & Informat Syst, Rua Campo Alegre 823, P-4100 Oporto, Portugal. RP Camacho, M (reprint author), Tripler Army Med Ctr, Div Sleep Surg & Med, Otolaryngol Head & Neck Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM drcamachoent@yahoo.com RI FMUP, CINTESIS/C-6631-2014; OI FMUP, CINTESIS/0000-0001-7248-2086; Camacho, Macario/0000-0001-9200-9085 NR 67 TC 5 Z9 5 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0023-852X EI 1531-4995 J9 LARYNGOSCOPE JI Laryngoscope PD MAY PY 2016 VL 126 IS 5 BP 1246 EP 1255 DI 10.1002/lary.25827 PG 10 WC Medicine, Research & Experimental; Otorhinolaryngology SC Research & Experimental Medicine; Otorhinolaryngology GA DK2UH UT WOS:000374769400046 PM 26691675 ER PT J AU Burgess, E AF Burgess, Edwin TI Douglas MacArthur: American Warrior SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin] US Army Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, E (reprint author), US Army Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD MAY 1 PY 2016 VL 141 IS 8 BP 85 EP 86 PG 2 WC Information Science & Library Science SC Information Science & Library Science GA DK9IM UT WOS:000375244100162 ER PT J AU Cesur, R Sabia, JJ AF Cesur, Resul Sabia, Joseph J. TI WHEN WAR COMES HOME: THE EFFECT OF COMBAT SERVICE ON DOMESTIC VIOLENCE SO REVIEW OF ECONOMICS AND STATISTICS LA English DT Article ID INTIMATE PARTNER VIOLENCE; POSTTRAUMATIC-STRESS-DISORDER; SOCIAL-SECURITY DATA; MILITARY SERVICE; MENTAL-HEALTH; VIETNAM-ERA; FAMILY VIOLENCE; DRAFT LOTTERY; CHILD-ABUSE; US ARMY AB This study is the first to estimate the effect of war service in the Global War on Terrorism on domestic violence. We exploit a natural experiment in overseas deployment assignment among active-duty servicemen by relying on theoretical and empirical evidence that, conditional on military rank and occupation, deployment assignments are orthogonal to the propensity for violence. Our results show that assignment to combat substantially increases the probability of intimate partner violence and child abuse. Descriptive evidence suggests that the effects may be explained in part by the stress- and substance use-related consequences of war. C1 [Cesur, Resul] Univ Connecticut, Mansfield, PA USA. [Sabia, Joseph J.] Univ New Hampshire, Durham, NH 03824 USA. [Sabia, Joseph J.] US Mil Acad, Washington, DC USA. RP Cesur, R (reprint author), Univ Connecticut, Mansfield, PA USA. FU National Institute of Child Health and Human Development [P01-HD31921] FX This research uses data from Add Health, a program project designed by J. Richard Udry, Peter S. Bearman, and Kathleen Mullan Harris, and funded by a grant P01-HD31921 from the National Institute of Child Health and Human Development, with cooperative funding from seventeen other agencies. NR 87 TC 0 Z9 0 U1 6 U2 17 PU MIT PRESS PI CAMBRIDGE PA ONE ROGERS ST, CAMBRIDGE, MA 02142-1209 USA SN 0034-6535 EI 1530-9142 J9 REV ECON STAT JI Rev. Econ. Stat. PD MAY PY 2016 VL 98 IS 2 BP 209 EP 225 DI 10.1162/REST_a_00541 PG 17 WC Economics; Social Sciences, Mathematical Methods SC Business & Economics; Mathematical Methods In Social Sciences GA DK3UF UT WOS:000374842200001 ER PT J AU Seelig, AD Jacobson, IG Donoho, CJ Trone, DW Crum-Cianflone, NF Balkin, TJ AF Seelig, Amber D. Jacobson, Isabel G. Donoho, Carrie J. Trone, Daniel W. Crum-Cianflone, Nancy F. Balkin, Thomas J. TI Sleep and Health Resilience Metrics in a Large Military Cohort SO SLEEP LA English DT Article DE cohort; military; resilience; sleep ID MILLENNIUM COHORT; US MILITARY; MENTAL-HEALTH; CARE UTILIZATION; RISK-FACTORS; PRIME-MD; DEPRIVATION; PREVALENCE; DEPLOYMENT; PERSONNEL AB Study Objectives: Examine the relationship between self-reported sleep parameters and indicators of resilience in a US military population (n = 55,021). Methods: Longitudinal analyses (2001-2008) were conducted using subjective data collected from Millennium Cohort Study questionnaires and objective data from military records that included demographics, military health, and deployment information. Subjective sleep duration and insomnia symptoms were collected on the study questionnaire. Resilience metrics included lost work days, self-rated health, deployment, frequency and duration of health care utilization, and early discharge from the military. Generalized estimating equations and survival analyses were adjusted for demographic, military, behavioral, and health covariates in all models. Results: The presence of insomnia symptoms was significantly associated with lower self-rated health, more lost work days, lower odds of deployment, higher odds of early discharge from military service early, and more health care utilization. Those self-reporting < 6 h (short sleepers) or > 8 h (long sleepers) of sleep per night had similar findings, except for the deployment outcome in which those with the shortest sleep were more likely to deploy. Conclusions: Poor sleep is a detriment to service members' health and readiness. Leadership should redouble efforts to emphasize the importance of healthy sleep among military service members, and future research should focus on the efficacy of interventions to promote healthy sleep and resilience in this population. C1 [Seelig, Amber D.; Jacobson, Isabel G.; Donoho, Carrie J.; Trone, Daniel W.; Crum-Cianflone, Nancy F.] Naval Hlth Res Ctr, San Diego, CA USA. [Donoho, Carrie J.] Uniformed Serv Univ Hlth Sci, Dept Psychiat, Bethesda, MD 20814 USA. [Crum-Cianflone, Nancy F.] Naval Med Ctr San Diego, San Diego, CA USA. [Balkin, Thomas J.] Walter Reed Army Inst Res, Behav Biol Branch, Silver Spring, MD USA. RP Jacobson, IG (reprint author), Naval Hlth Res Ctr, Deployment Hlth Res Dept, 140 Sylvester Rd, San Diego, CA 92106 USA. EM Isabel.G.Jacobson.ctr@mail.mil FU Military Operational Medicine Research Program of the US Army Medical Research and Materiel Command, Fort Detrick, Maryland; Bureau of Medicine and Surgery [60002] FX This was not an industry supported study. The Millennium Cohort Study is funded through the Military Operational Medicine Research Program of the US Army Medical Research and Materiel Command, Fort Detrick, Maryland, and the Bureau of Medicine and Surgery, under Work Unit No. 60002. The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of the Navy, Department of the Army, Department of Defense, Department of Veterans Affairs, or the US Government. Approved for public release; distribution is unlimited. US Government Work (17 USC 105). Not copyrighted in the US. This research has been conducted in compliance with all applicable federal regulations governing the protection of human subjects in research (Protocol NHRC. 2000.0007). The authors have indicated no financial conflicts of interest. NR 52 TC 1 Z9 1 U1 1 U2 3 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 EI 1550-9109 J9 SLEEP JI Sleep PD MAY 1 PY 2016 VL 39 IS 5 BP 1111 EP 1120 AR PII sp-00323-15 DI 10.5665/sleep.5766 PG 10 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA DK8PE UT WOS:000375188400019 PM 26951391 ER PT J AU Smith, JM Bryant, MA Wamsley, TV AF Smith, Jane McKee Bryant, Mary Anderson Wamsley, Ty V. TI Wetland buffers: numerical modeling of wave dissipation by vegetation SO EARTH SURFACE PROCESSES AND LANDFORMS LA English DT Article DE wetlands; wave dissipation; coastal storms; vegetation; nature-based ID REDUCING STORM-SURGE; SALT-MARSH VEGETATION; ENERGY-DISSIPATION; CLIMATE-CHANGE; ATTENUATION; MANGROVES; IMPACT; FIELD AB The resiliency of coastal communities is imperative because these areas experience risk of damage from coastal storms as well as increasing population pressures and development. The severity of this hazard is compounded by sea level rise and a potential increase in storm intensities due to climate change. The ability of coastal communities to plan for, resist, and quickly and completely recover from severe coastal storm events and flooding is of critical importance. There is a growing interest in applying complementary and redundant approaches to reduce the flood risk of these vulnerable communities, such as incorporating natural and nature-based features into the project planning process. However, accounting for the benefits of these nature-based features in coastal design is still challenging. One of the natural features generally acknowledged to offer coastal protection benefits is wetlands. Using laboratory experiments of artificial vegetation as a foundation, the bounds of wave dissipation by vegetation are explored analytically and the effectiveness of wave dissipation by vegetation over large scales is investigated using the spectral wave model STWAVE. Wave heights modeled using a vegetation dissipation formulation are compared to those modeled with the current practice of representing vegetation using bottom friction, particularly the Manning formulation. The vegetation dissipation formulation reduced more wave energy than the Manning bottom friction formulation for submerged wetlands. Because the Manning formulation does not integrate vegetation properties, to achieve consistent results would require varying the Manning n coefficient to account for the spatial and temporal variation in form drag induced by the plants due to changes in plant density, diameter, and degree of plant submergence. Thus, a re-evaluation of existing methods for assessing wave dissipation by vegetation is recommended for wider application of vegetation dissipation formulations in numerical models. Such models are critical for evaluating coastal resiliency of communities protected by wetland features. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. C1 [Smith, Jane McKee; Bryant, Mary Anderson; Wamsley, Ty V.] US Army, Engn Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS USA. RP Bryant, MA (reprint author), 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Mary.Bryant@usace.army.mil NR 41 TC 3 Z9 3 U1 10 U2 28 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0197-9337 EI 1096-9837 J9 EARTH SURF PROC LAND JI Earth Surf. Process. Landf. PD MAY PY 2016 VL 41 IS 6 BP 847 EP 854 DI 10.1002/esp.3904 PG 8 WC Geography, Physical; Geosciences, Multidisciplinary SC Physical Geography; Geology GA DK1TP UT WOS:000374697500009 ER PT J AU Ketter, P Yu, JJ Cap, AP Forsthuber, T Arulanandam, B AF Ketter, Patrick Yu, Jieh-Juen Cap, Andrew P. Forsthuber, Thomas Arulanandam, Bernard TI Pentraxin 3: an immune modulator of infection and useful marker for disease severity assessment in sepsis SO EXPERT REVIEW OF CLINICAL IMMUNOLOGY LA English DT Article DE Pentraxin 3; PTX3; sepsis; coagulopathy; inflammation; pattern recognition receptor; diagnostic markers; regulation ID PATTERN-RECOGNITION RECEPTOR; C-REACTIVE PROTEIN; ACUTE MYOCARDIAL-INFARCTION; TISSUE FACTOR EXPRESSION; ACUTE-PHASE PROTEINS; SERUM AMYLOID-P; ASPERGILLUS-FUMIGATUS; DENDRITIC CELLS; INNATE IMMUNITY; COMPLEMENT ACTIVATION AB The acute phase protein pentraxin 3 (PTX3) is a pattern recognition receptor involved in regulation of the host immune response. This relatively newly discovered member of the pentraxin superfamily elicits both immunostimulatory and immunoregulatory functions preventing autoimmune pathology and orchestrated clearance of pathogens through opsonization of damage- and pathogen-associated molecular patterns (DAMP/PAMP). Thus, PTX3 has been described as a possible evolutionary precursor to immunoglobulins. While shown to provide protection against specific bacterial and fungal pathogens, persistent elevation of PTX3 levels following initial onset of infection appear to predict poor patient outcome and may contribute to disease sequelae such as tissue damage and coagulopathy. Measurement of PTX3 following onset of sepsis may improve patient risk assessment and thus be useful in guiding subsequent therapeutic interventions including steroidal anti-inflammatory and altered antibiotic therapies. In this review, we summarize the role of PTX3 in inflammatory syndromes and its utility as a marker of sepsis disease severity. C1 [Ketter, Patrick; Cap, Andrew P.] US Army, Inst Surg Res, JBSA, Blood & Coagulat Program, Ft Sam Houston, TX USA. [Yu, Jieh-Juen; Forsthuber, Thomas; Arulanandam, Bernard] Univ Texas San Antonio, Dept Biol, One UTSA Circle, San Antonio, TX 78249 USA. RP Arulanandam, B (reprint author), Univ Texas San Antonio, One UTSA Circle, San Antonio, TX 78249 USA. EM bernard.arulanandam@utsa.edu FU U.S. Army Medical Research and Material Command; Army Research Office of the Department of Defense [W911NF-11-1-0136]; U.S. Department of Homeland Security [DHS 2014-ST-062-000058]; Alvarez Graduate Research Education Excellence Fund FX This research was partially funded by the U.S. Army Medical Research and Material Command, the Army Research Office of the Department of Defense [Contract Number: W911NF-11-1-0136], the U.S. Department of Homeland Security [DHS 2014-ST-062-000058], and the Alvarez Graduate Research Education Excellence Fund. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. NR 92 TC 1 Z9 1 U1 4 U2 6 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1744-666X EI 1744-8409 J9 EXPERT REV CLIN IMMU JI Expert Rev. Clin. Immunol. PD MAY PY 2016 VL 12 IS 5 BP 501 EP 507 DI 10.1586/1744666X.2016.1166957 PG 7 WC Immunology SC Immunology GA DK1SJ UT WOS:000374694100004 PM 26982005 ER PT J AU Gemeinhardt, TR Gosch, NJC Morris, DM Miller, ML Welker, TL Bonneau, JL AF Gemeinhardt, T. R. Gosch, N. J. C. Morris, D. M. Miller, M. L. Welker, T. L. Bonneau, J. L. TI Is Shallow Water a Suitable Surrogate for Assessing Efforts to Address Pallid Sturgeon Population Declines? SO RIVER RESEARCH AND APPLICATIONS LA English DT Article DE shallow water; habitat restoration; pallid sturgeon; Missouri River ID LOWER MISSOURI RIVER; SHOVELNOSE STURGEON; HABITAT USE; AGE-0 STURGEON; FISHES; FLOW; FOOD; DISPERSAL; MONTANA; EXAMPLE AB It is hypothesized that slow, shallow water habitats benefit larval pallid sturgeon Scaphirhynchus albus; however, testing this hypothesis is difficult, given the low number of larval pallid sturgeon present in large rivers. In contrast, relatively large numbers of age-0 shovelnose sturgeon Scaphirhynchus platorynchus have been sampled, providing a potentially useful baseline to assess the importance of slow, shallow water to age-0 sturgeon of both species (hereafter age-0 sturgeon) in the lower Missouri River. Thus, we investigated the potential relationships between the prevalence of shallow water <1.5m and the age-0 sturgeon catch rates at multiple scales. Age-0 sturgeon were usually sampled in water >1.5m, and catch rates were usually highest in the upper half [i.e. river kilometre (RKM) 400 to 800] of the lower Missouri River study area, whereas the availability of water <1.5m was usually highest in the lower half (i.e. RKM 0 to 400). Similarly, there was no relationship between age-0 sturgeon mean catch-per-unit effort and ha/km of water <1.5m at any studied scale. Our results may suggest that shallow water, as currently defined, may not be a suitable surrogate for assessing efforts to address pallid sturgeon population declines. However, it is still unknown if lack of appropriate habitat is currently limiting pallid sturgeon. Published 2015. This article is a U.S. Government work and is in the public domain in the USA. River Research and Applications published by John Wiley & Sons Ltd. C1 [Gemeinhardt, T. R.; Gosch, N. J. C.; Morris, D. M.; Miller, M. L.] US Army Corps Engineers, Kansas City, MO USA. [Welker, T. L.; Bonneau, J. L.] US Army Corps Engineers, Yankton, SD USA. RP Gemeinhardt, TR (reprint author), US Army Corps Engineers, Kansas City, MO USA. EM todd.r.gemeinhardt@usace.army.mil FU USACE, Kansas City, and Omaha Districts FX Funding was provided by the USACE, Kansas City, and Omaha Districts. We thank the Nebraska Game and Parks Commission, Missouri Department of Conservation, and USFWS for the PSPAP data access. Jason Farmer and Chance Bitner provided valuable comments on an earlier draft of this manuscript. Reference to trade names does not imply endorsement by the US government. All product names and trademarks cited are the property of their respective owners. The findings of this report are not to be construed as an official Department of Army position unless so designated by other authorized documents. NR 48 TC 3 Z9 3 U1 4 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1535-1459 EI 1535-1467 J9 RIVER RES APPL JI River Res. Appl. PD MAY PY 2016 VL 32 IS 4 BP 734 EP 743 DI 10.1002/rra.2889 PG 10 WC Environmental Sciences; Water Resources SC Environmental Sciences & Ecology; Water Resources GA DK1WE UT WOS:000374704900019 ER PT J AU Tripp, S Killgore, KJ Garvey, JE AF Tripp, S. Killgore, K. Jack Garvey, J. E. TI Fish Movements and Passage Through a Water Control Structure: River Stage and Floodplain Connectivity SO RIVER RESEARCH AND APPLICATIONS LA English DT Article DE fish passage; floodplain connectivity; water control structure; river stage ID UPPER MISSISSIPPI RIVER; ASSEMBLAGES; CALIFORNIA; HABITATS AB The St. John's Bayou water control structure near New Madrid, MO, connects the main Mississippi River to two large backwater areas called the New Madrid Floodway and St. John's Bayou. While this area has been altered, the New Madrid Floodway and St. John's Bayou account for the only substantial portion of the historic Mississippi River floodplain that remains and provides the only critical connection between backwater/floodplain habitat and the river. Fish passage was evaluated during April-December 2010 using ultrasonic telemetry. Stationary receivers were placed strategically at five locations above and below the structure in St. John's Bayou, in the floodway and the outlet to the Mississippi River. A total of 100 individuals representing 14 species were tagged. Total number of detections during an 8-month period was 1264717. Fifteen individuals representing five species moved into the Mississippi and Ohio rivers; seven individuals returned to St. John's Bayou. Thirteen of the 14 species moved upstream through the structure. Of the 85 individuals that stayed in the bayou, 29 fish passed through the structure for a total of 92 passage events. The downstream:upstream passage was roughly 50:50. Passage was correlated with river rise, with frequency of passage being higher in spring, but passage occurred each month during the study. Copyright (c) 2015 John Wiley & Sons, Ltd. C1 [Tripp, S.] Missouri Dept Conservat, Big Rivers & Wetlands Field Stn, 3815 East Jackson Blvd, Jackson, MO 63755 USA. [Killgore, K. Jack] US Army Corps Engineers, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS USA. [Garvey, J. E.] So Illinois Univ, Dept Zool, Ctr Ecol, Ctr Fisheries Aquaculture & Aquat Sci, Carbondale, IL 62901 USA. RP Tripp, S (reprint author), Missouri Dept Conservat, Big Rivers & Wetlands Field Stn, 3815 East Jackson Blvd, Jackson, MO 63755 USA. EM sara.tripp@mdc.mo.gov FU Ecosystem Management and Restoration Research Program at the Engineer Research and Development Center FX Funding was provided by the Memphis District, Mr Danny Ward, Project Manager, and the Ecosystem Management and Restoration Research Program at the Engineer Research and Development Center. Field assistance was provided by ERDC-EL Fish Ecology Team (Jan Hoover, Steven George, Bradley Lewis, Todd Slack, Jay Collins and Neil Douglas) and the Missouri Department of Conservation. NR 19 TC 0 Z9 0 U1 5 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1535-1459 EI 1535-1467 J9 RIVER RES APPL JI River Res. Appl. PD MAY PY 2016 VL 32 IS 4 BP 812 EP 819 DI 10.1002/rra.2901 PG 8 WC Environmental Sciences; Water Resources SC Environmental Sciences & Ecology; Water Resources GA DK1WE UT WOS:000374704900027 ER PT J AU Uhl, ER Camilletti, CR Scullin, MH Wood, JM AF Uhl, Elizabeth R. Camilletti, Catherine R. Scullin, Matthew H. Wood, James M. TI Under Pressure: Individual Differences in Children's Suggestibility in Response to Intense Social Influence SO SOCIAL DEVELOPMENT LA English DT Article DE suggestibility; social understanding; children; individual differences ID INTERROGATIVE SUGGESTIBILITY; MEMORY; MIND; SUGGESTIONS AB Prior research on the relation between children's suggestibility and verbal skills has yielded mixed results. This study examined children's suggestibility in a high social pressure context in conjunction with individual differences in verbal ability and social understanding. Sixty-nine children were read a story by a classroom visitor. One week later children were asked suggestive questions about the visit and pressured to respond yes'. One week after the first interview, children were re-asked the same questions, this time with no pressure. Children's suggestibility in response to social pressure was found to be significantly and negatively correlated with receptive vocabulary knowledge, but not with social understanding, the ability to understand and interpret social interactions. In addition, suggestibility scores exhibited a distinctly bimodal distribution, with many children acquiescing to all pressured suggestions, many children acquiescing to no suggestions, and few children falling between these two extremes. C1 [Uhl, Elizabeth R.; Camilletti, Catherine R.; Scullin, Matthew H.; Wood, James M.] Univ Texas El Paso, El Paso, TX 79968 USA. RP Uhl, ER (reprint author), US Army Res Inst, POB 52086, Ft Benning, GA 31995 USA. EM elizabeth.r.uhl.civ@mail.mil NR 23 TC 0 Z9 0 U1 4 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0961-205X EI 1467-9507 J9 SOC DEV JI Soc. Dev. PD MAY PY 2016 VL 25 IS 2 BP 422 EP 434 DI 10.1111/sode.12156 PG 13 WC Psychology, Developmental SC Psychology GA DJ5PA UT WOS:000374260300012 ER PT J AU Butkus, MA Riegner, DE Olind, J AF Butkus, Michael A. Riegner, Dawn E. Olind, Johannes TI Immobilization of lead by phosphate amended Polonite SO CHEMOSPHERE LA English DT Article DE Stabilization; Lead oxide; Pb4O(PO4)(2); Pozzolanic reaction products; LDI-TOF ID WASTE-WATER TREATMENT; X-RAY-ABSORPTION; SHOOTING-RANGE SOILS; MASS-SPECTROMETRY; METAL REMOVAL; FILTER MEDIA; PHOSPHORUS; HYDROXYAPATITES; ORTHOPHOSPHATES; SPECTROSCOPY AB Polonite is an alkaline material that is used to remove nutrients from domestic wastewater and it has been evaluated as a fertilizer. Stabilization of Pb by Polonite and Polonite amended with orthophosphate, PO4, (Polonite-P) was studied. Octacalcium phosphate (Ca8H2(PO4)(6)center dot 5H(2)O) was a primary species of PO4 formed on the surface of Polonite-P. Lead was found to be associated with pozzolanic reaction products in Pb treated Polonite and Pb treated Polonite-P samples. Formation of Pb oxides, as precipitates or surface complexes, were substantial constituents of Pb treated Polonite. Dissolution of Ca8H2(PO4)(6).5H(2)O followed by formation of Pb4O(PO4)(2) was a probable mechanism of Pb removal by Polonite-P. Polonite-P could be a suitable replacement for current PO4 sources as a Pb stabilization agent. Finally, LDI-TOF was an effective technique for evaluating forms of Pb on Polonite and Polonite-P. Published by Elsevier Ltd. C1 [Butkus, Michael A.; Olind, Johannes] US Mil Acad, Dept Geog & Environm Engn, Environm Engn Program, West Point, NY 10996 USA. [Riegner, Dawn E.] US Mil Acad, Dept Chem & Life Sci, Chem Program, West Point, NY 10996 USA. RP Butkus, MA (reprint author), US Mil Acad, Dept Geog & Environm Engn, Environm Engn Program, West Point, NY 10996 USA. EM Michael.Butkus@usma.edu FU U.S. Army Research Laboratory FX The technical assistance of Mr. Anand Shetty, Mr. Mark Lennox, and Ms. Taylor Pearce, Department of Geography and Environmental Engineering, United States Military Academy is greatly appreciated. The technical assistance of Christina Tricomi, Department of Chemistry and Life Science, United States Military Academy is greatly appreciated. This project was supported by a grant from the U.S. Army Research Laboratory. Although the research presented in this paper has been undertaken by personnel employed by US Military Academy, it does not necessarily reflect the views of the Academy or the US Army. NR 39 TC 1 Z9 1 U1 9 U2 18 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 EI 1879-1298 J9 CHEMOSPHERE JI Chemosphere PD MAY PY 2016 VL 151 BP 310 EP 317 DI 10.1016/j.chemosphere.2016.02.066 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA DJ2YK UT WOS:000374071000038 PM 26950021 ER PT J AU Schaefer, KE Chen, JYC Szalma, JL Hancock, PA AF Schaefer, Kristin E. Chen, Jessie Y. C. Szalma, James L. Hancock, P. A. TI A Meta-Analysis of Factors Influencing the Development of Trust in Automation: Implications for Understanding Autonomy in Future Systems SO HUMAN FACTORS LA English DT Review DE human-automation interaction; human-robot interaction; meta-analysis; trust ID ADAPTIVE CRUISE CONTROL; HUMAN-FACTORS ISSUES; COLLISION WARNING SYSTEMS; AIR-TRAFFIC MANAGEMENT; DRIVER TRUST; INDIVIDUAL-DIFFERENCES; IMPERFECT AUTOMATION; SELF-CONFIDENCE; PERFORMANCE CONSEQUENCES; HUMAN INTERVENTION AB Objective: We used meta-analysis to assess research concerning human trust in automation to understand the foundation upon which future autonomous systems can be built. Background: Trust is increasingly important in the growing need for synergistic human-machine teaming. Thus, we expand on our previous meta-analytic foundation in the field of human-robot interaction to include all of automation interaction. Method: We used meta-analysis to assess trust in automation. Thirty studies provided 164 pairwise effect sizes, and 16 studies provided 63 correlational effect sizes. Results: The overall effect size of all factors on trust development was (g) over bar = +0.48, and the correlational effect was = +0.34, each of which represented medium effects. Moderator effects were observed for the human-related ((g) over bar = +0.49; (r) over bar = +0.16) and automation-related ((g) over bar = +0.53; (r) over bar = +0.41) factors. Moderator effects specific to environmental factors proved insufficient in number to calculate at this time. Conclusion: Findings provide a quantitative representation of factors influencing the development of trust in automation as well as identify additional areas of needed empirical research. Application: This work has important implications to the enhancement of current and future human-automation interaction, especially in high-risk or extreme performance environments. C1 [Schaefer, Kristin E.] US Army Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD USA. [Chen, Jessie Y. C.] US Army Res Lab, Human Res & Engn Directorate, Orlando, FL USA. [Szalma, James L.; Hancock, P. A.] Univ Cent Florida, Dept Psychol, Orlando, FL 32816 USA. [Hancock, P. A.] Univ Cent Florida, Inst Simulat & Training, Orlando, FL 32816 USA. RP Schaefer, KE (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD USA. EM kristin.e.schaefer2.ctr@mail.mil FU U.S. Army Research Laboratory [W911NF-10-2-0016, W911-NF-12-2-0019] FX This research was sponsored by the U.S. Army Research Laboratory and was accomplished under Cooperative Agreement Nos. W911NF-10-2-0016 and W911-NF-12-2-0019. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. government. The U.S. government is authorized to reproduce and distribute reprints for government purposes notwithstanding any copyright notation herein. The authors would also like to acknowledge the various research assistants and support staff from the University of Central Florida who were associated with the generation and submission of the document. We also acknowledge Susan Hill, Donald Headley, and John F. Lockett III, U.S. Army Research Laboratory, for their internal technical reviews and support as well as our external technical reviewers. NR 159 TC 3 Z9 3 U1 14 U2 29 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0018-7208 EI 1547-8181 J9 HUM FACTORS JI Hum. Factors PD MAY PY 2016 VL 58 IS 3 BP 377 EP 400 DI 10.1177/0018720816634228 PG 24 WC Behavioral Sciences; Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology SC Behavioral Sciences; Engineering; Psychology GA DJ1HW UT WOS:000373954900001 PM 27005902 ER PT J AU Mercado, JE Rupp, MA Chen, JYC Barnes, MJ Barber, D Procci, K AF Mercado, Joseph E. Rupp, Michael A. Chen, Jessie Y. C. Barnes, Michael J. Barber, Daniel Procci, Katelyn TI Intelligent Agent Transparency in Human-Agent Teaming for Multi-UxV Management SO HUMAN FACTORS LA English DT Article DE intelligent agent transparency; human-agent teaming; multi-UxV management ID COMBAT IDENTIFICATION SYSTEM; SUPERVISORY CONTROL; WORKING-MEMORY; EYE-MOVEMENTS; AUTOMATION; PERFORMANCE; RELIANCE; TRUST; ATTENTION; AWARENESS AB Objective: We investigated the effects of level of agent transparency on operator performance, trust, and workload in a context of human-agent teaming for multirobot management. Background: Participants played the role of a heterogeneous unmanned vehicle (UxV) operator and were instructed to complete various missions by giving orders to UxVs through a computer interface. An intelligent agent (IA) assisted the participant by recommending two plansa top recommendation and a secondary recommendationfor every mission. Method: A within-subjects design with three levels of agent transparency was employed in the present experiment. There were eight missions in each of three experimental blocks, grouped by level of transparency. During each experimental block, the IA was incorrect three out of eight times due to external information (e.g., commander's intent and intelligence). Operator performance, trust, workload, and usability data were collected. Results: Results indicate that operator performance, trust, and perceived usability increased as a function of transparency level. Subjective and objective workload data indicate that participants' workload did not increase as a function of transparency. Furthermore, response time did not increase as a function of transparency. Conclusion: Unlike previous research, which showed that increased transparency resulted in increased performance and trust calibration at the cost of greater workload and longer response time, our results support the benefits of transparency for performance effectiveness without additional costs. Application: The current results will facilitate the implementation of IAs in military settings and will provide useful data to the design of heterogeneous UxV teams. C1 [Mercado, Joseph E.] US Army Res Lab, Human Res & Engn Directorate, 340 Hulse Rd, Pensacola, FL 32508 USA. [Rupp, Michael A.] Univ Cent Florida, Orlando, FL 32816 USA. [Chen, Jessie Y. C.] US Army Res Lab, Human Res & Engn Directorate, Field Element, Orlando, FL 32508 USA. [Barnes, Michael J.] US Army Res Lab, Orlando, FL 32508 USA. [Barber, Daniel] Univ Cent Florida, Inst Simulat & Training, Orlando, FL 32816 USA. [Procci, Katelyn] Univ Cent Florida, Orlando, FL 32816 USA. RP Mercado, JE (reprint author), US Army Res Lab, Human Res & Engn Directorate, 340 Hulse Rd, Pensacola, FL 32508 USA. EM joseph.mercado@med.navy.mil FU Department of Defense Autonomy Research Pilot Initiative, under the Intelligent Multi-UxV Planner With Adaptive Collaborative/Control Technologies (IMPACT) project FX This research was supported by the Department of Defense Autonomy Research Pilot Initiative, under the Intelligent Multi-UxV Planner With Adaptive Collaborative/Control Technologies (IMPACT) project. We wish to thank Isacc Yi, Erica Valiente, Shan Lakhmani, and Jonathan Harris for their contribution to this project. We would also like to thank Gloria Calhoun and Mark Draper for their input. NR 47 TC 3 Z9 3 U1 4 U2 10 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0018-7208 EI 1547-8181 J9 HUM FACTORS JI Hum. Factors PD MAY PY 2016 VL 58 IS 3 BP 401 EP 415 DI 10.1177/0018720815621206 PG 15 WC Behavioral Sciences; Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology SC Behavioral Sciences; Engineering; Psychology GA DJ1HW UT WOS:000373954900002 PM 26867556 ER PT J AU Dao, M Nguyen, NH Nasrabadi, NM Tran, TD AF Dao, Minh Nguyen, Nam H. Nasrabadi, Nasser M. Tran, Trac D. TI Collaborative Multi-Sensor Classification Via Sparsity-Based Representation SO IEEE TRANSACTIONS ON SIGNAL PROCESSING LA English DT Article DE Multisensor; joint-sparse representation; groupsparse representation; low-rank; kernel; classification ID HYPERSPECTRAL IMAGE CLASSIFICATION; FACE RECOGNITION; DATA FUSION; RECOVERY; REGRESSION; ALGORITHM AB In this paper, we propose a general collaborative sparse representation framework for multi-sensor classification, which takes into account the correlations as well as complementary information between heterogeneous sensors simultaneously while considering joint sparsity within each sensor's observations. We also robustify our models to deal with the presence of sparse noise and low-rank interference signals. Specifically, we demonstrate that incorporating the noise or interference signal as a low-rank component in our models is essential in a multi-sensor classification problem when multiple co-located sources/sensors simultaneously record the same physical event. We further extend our frameworks to kernelized models which rely on sparsely representing a test sample in terms of all the training samples in a feature space induced by a kernel function. A fast and efficient algorithm based on alternative direction method is proposed where its convergence to an optimal solution is guaranteed. Extensive experiments are conducted on several real multi-sensor data sets and results are compared with the conventional classifiers to verify the effectiveness of the proposed methods. C1 [Dao, Minh; Tran, Trac D.] Johns Hopkins Univ, Dept Elect & Comp Engn, Baltimore, MD 21218 USA. [Nguyen, Nam H.] MIT, Dept Math, Cambridge, MA 02139 USA. [Nasrabadi, Nasser M.] US Army Res Lab, Adelphi, MD 20783 USA. RP Dao, M; Tran, TD (reprint author), Johns Hopkins Univ, Dept Elect & Comp Engn, Baltimore, MD 21218 USA.; Nguyen, NH (reprint author), MIT, Dept Math, Cambridge, MA 02139 USA.; Nasrabadi, NM (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM minh.dao@jhu.edu; namnguyen@math.mit.edu; nasser.m.nasrabadi.civ@mail.mil; trac@jhu.edu FU National Science Foundation [CCF-1117545, CCF-1422995]; Army Research Office [60219-MA]; Office of Naval Research [N00014-12-1-0765]; Army Research Laboratory SOAR Program FX This work was supported in part by the National Science Foundation under Grants CCF-1117545 and CCF-1422995, by the Army Research Office under Grant 60219-MA, by the Office of Naval Research under Grant N00014-12-1-0765, and by the Army Research Laboratory SOAR Program. NR 47 TC 0 Z9 0 U1 7 U2 16 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1053-587X EI 1941-0476 J9 IEEE T SIGNAL PROCES JI IEEE Trans. Signal Process. PD MAY 1 PY 2016 VL 64 IS 9 BP 2400 EP 2415 DI 10.1109/TSP.2016.2521605 PG 16 WC Engineering, Electrical & Electronic SC Engineering GA DJ1FA UT WOS:000373947500018 ER PT J AU Jeong, HS Layher, H Cao, L Vandergriff, T Dominguez, AR AF Jeong, Haneol S. Layher, Heather Cao, Lauren Vandergriff, Travis Dominguez, Arturo R. TI Pyoderma gangrenosum (PG) associated with levamisole-adulterated cocaine: Clinical, serologic, and histopathologic findings in a cohort of patients SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article DE cocaine; dermatosis; immunologic markers; levamisole; pyoderma gangrenosum AB Background: Recently, isolated reports of pyoderma gangrenosum (PG) secondary to levamisole-contaminated cocaine have been described, with similar serologic findings to the vasculopathic presentation. Objective: We sought to describe clinical, histopathological, and serologic findings in 8 patients with PG associated with levamisole-contaminated cocaine. Methods: Eight consecutive patients presenting with this disease spanning the period from 2011 to 2015 were included for the cohort. Observed variables included: lesion distribution, morphology, serologic titers, and histopathologic evaluation for vasculitis and vasculopathy. Results: All patients reported cocaine exposure prior to the onset of lesions resembling PG. Lesions appeared primarily on the upper (6 of 8 patients) and lower (all 8 patients) extremities. Most patients demonstrated elevated titers for p-ANCA and antiphospholipid antibodies, and a diffuse dermal infiltrate dominated by neutrophils was seen in all biopsy specimens. Lesions improved or remained stable with conservative management or short courses of steroids, and recurrence was only noted on re-exposure to adulterated cocaine. Limitations: The study is limited by sample size. Conclusions: PG may occur after exposure to levamisole-adulterated cocaine. Clinical and histopathological findings resemble those seen in conventional forms of PG, whereas serologic findings mirror those seen in other levamisole-associated vasculopathic or vasculitic eruptions. Cocaine avoidance represents a cornerstone of management in these patients. C1 [Jeong, Haneol S.; Cao, Lauren; Vandergriff, Travis; Dominguez, Arturo R.] Univ Texas SW Med Ctr Dallas, Dept Dermatol, 5323 Harry Hines Blvd, Dallas, TX 75390 USA. [Layher, Heather] Brooke Army Med Ctr, San Antonio Uniformed Serv Hlth Educ Consortium, Dermatol Residency Program, San Antonio, TX USA. RP Dominguez, AR (reprint author), Univ Texas SW Med Ctr Dallas, Dept Dermatol, 5323 Harry Hines Blvd, Dallas, TX 75390 USA. EM arturo.dominguez@utsouthwestern.edu OI Dominguez, Arturo/0000-0001-8488-3194; Vandergriff, Travis/0000-0001-6577-3838 NR 16 TC 0 Z9 0 U1 0 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD MAY PY 2016 VL 74 IS 5 BP 892 EP 898 DI 10.1016/j.jaad.2015.11.040 PG 7 WC Dermatology SC Dermatology GA DJ3PF UT WOS:000374117100021 PM 26785804 ER PT J AU Zhao, BB Duan, WY Demirbilek, Z Ertekin, RC Webster, WC AF Zhao, B. B. Duan, W. Y. Demirbilek, Z. Ertekin, R. C. Webster, W. C. TI A comparative study between the IGN-2 equations and the fully nonlinear, weakly dispersive Boussinesq equations SO COASTAL ENGINEERING LA English DT Article DE Irrotational Green-Naghdi equations; IGN-2 equations; Boussinesq equations; Steady water waves; Nonlinear and weakly dispersive waves ID GREEN-NAGHDI EQUATIONS; WATER-WAVES; SHALLOW; MODEL; DIFFRACTION; DEPTH AB This work focuses on the comparison between the fully nonlinear, and weakly dispersive Boussinesq equations and the irrotational Green-Naghdi Level 2 (IGN-2) equations for incompressible and inviscid fluid and irrotational flow resulting from waves in finite water depth. We provide in this paper for the first time a comprehensive comparison of the GN/IGN and Boussinesq wave theories for strongly nonlinear and weakly dispersive waves. The Boussinesq approach results in many different theories depending on the different orders of approximation of nonlinearity and dispersion used in the corresponding perturbation series. The fully nonlinear, weakly dispersive Boussinesq equations have been widely used in problems involving coastal regions and harbors because it is more efficient than fully nonlinear, strongly dispersive Boussinesq equations. A competing theory is the strongly nonlinear IGN-2 wave theory. Since both sets of equations have comparable complexity, it is appropriate to compare the results of these equations with known numerically exact solutions to determine the advantages of each approach. In this study, we use the same iterative algorithm to obtain the steady solutions of the IGN-2 and Boussinesq equations for periodic waves. The steady solutions of the IGN-2 and Boussinesq equations are studied for four different wavelengths that cover a range of applicability of the theories. We show in this study that the Boussinesq equations give more accurate results for the velocity distribution at the wave-crest transection. The IGN-2 equations give more accurate results for the velocity distribution at the wave-trough transection. Moreover, it is shown that the IGN-2 equations give more accurate results on the wave speed and wave profile, and that they can treat accurately waves higher than the ones that the Boussinesq equations can treat. The calculations show that both of these sets of equations are very good for strongly nonlinear wave simulations and the limitations of each are different. (C) 2016 Elsevier B.V. All rights reserved. C1 [Zhao, B. B.; Duan, W. Y.; Ertekin, R. C.] Harbin Engn Univ, Coll Shipbldg Engn, Harbin 150001, Peoples R China. [Demirbilek, Z.] US Army, Coastal & Hydraul Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Ertekin, R. C.] Univ Hawaii, Dept Ocean & Resources Engn, Honolulu, HI 96822 USA. [Webster, W. C.] Univ Calif Berkeley, Civil & Environm Engn, Berkeley, CA 94720 USA. RP Duan, WY (reprint author), Harbin Engn Univ, Coll Shipbldg Engn, Harbin 150001, Peoples R China. EM duanwenyangheu@hotmail.com FU National Natural Science Foundation of China [11572093, 51490671]; International Science and Technology Cooperation Project - National Ministry of Science and Technology of China [2012DFA70420]; Special Fund for Basic Scientific Research of Central Colleges (Harbin Engineering University); High-Tech Ship Research Projects - Ministry of Industry and Information Technology (MIIT) of P.R. China FX The first and second authors' (BBZ and WYD) work is supported by the National Natural Science Foundation of China (No. 11572093, 51490671), International Science and Technology Cooperation Project sponsored by National Ministry of Science and Technology of China (No. 2012DFA70420), the Special Fund for Basic Scientific Research of Central Colleges (Harbin Engineering University) and High-Tech Ship Research Projects sponsored by the Ministry of Industry and Information Technology (MIIT) of P.R. China. NR 24 TC 0 Z9 0 U1 1 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-3839 EI 1872-7379 J9 COAST ENG JI Coast. Eng. PD MAY PY 2016 VL 111 BP 60 EP 69 DI 10.1016/j.coastaleng.2016.01.011 PG 10 WC Engineering, Civil; Engineering, Ocean SC Engineering GA DI5MZ UT WOS:000373544600006 ER PT J AU Roth, MJ Chen, JS Slawson, TR Danielson, KT AF Roth, Michael J. Chen, Jiun-Shyan Slawson, Thomas R. Danielson, Kent T. TI Stable and flux-conserved meshfree formulation to model shocks SO COMPUTATIONAL MECHANICS LA English DT Article DE Meshfree; Shock; Gibbs phenomenon; Riemann-enriched stabilized conforming nodal integration; Smoothed flux divergence ID KERNEL PARTICLE METHODS; ESSENTIALLY NONOSCILLATORY SCHEMES; CONFORMING NODAL INTEGRATION; REPRODUCING KERNEL; DIFFERENCE SCHEME; EULER EQUATIONS; LAWS; ADAPTIVITY AB Accurate shock modeling requires that two critical issues be addressed: (1) correct representation of the essential shock physics, and (2) control of Gibbs phenomenon oscillation at the discontinuity. In this work a stable (oscillation limiting) and flux-conserved formulation under the reproducing kernel particle method is developed for shock modeling. A smoothed flux divergence is constructed under the framework of stabilized conforming nodal integration, which is locally-enriched with a Riemann solution to satisfy the entropy production constraints. This Riemann-enriched flux divergence is embedded into the reproducing kernel formulation through a velocity correction that also provides oscillation control at the shock. The correction is constrained to the shock region by an automatic shock detection algorithm that is constructed using the intrinsic spectral decomposition feature of the reproducing kernel approximation. Several numerical examples are provided to verify accuracy of the proposed formulation. C1 [Roth, Michael J.; Slawson, Thomas R.; Danielson, Kent T.] US Army Engineer Res & Dev Ctr, Vicksburg, MS USA. [Chen, Jiun-Shyan] Univ Calif San Diego, Dept Struct Engn, San Diego, CA 92103 USA. RP Chen, JS (reprint author), Univ Calif San Diego, Dept Struct Engn, San Diego, CA 92103 USA. EM js-chen@ucsd.edu NR 44 TC 0 Z9 0 U1 1 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0178-7675 EI 1432-0924 J9 COMPUT MECH JI Comput. Mech. PD MAY PY 2016 VL 57 IS 5 BP 773 EP 792 DI 10.1007/s00466-016-1260-8 PG 20 WC Mathematics, Interdisciplinary Applications; Mechanics SC Mathematics; Mechanics GA DI7HH UT WOS:000373669600005 ER PT J AU Burroughs, JE Thomasson, JA Marsella, R Greiner, EC Allan, SA AF Burroughs, Jennifer E. Thomasson, J. Alex Marsella, Rosanna Greiner, Ellis C. Allan, Sandra A. TI Ticks associated with domestic dogs and cats in Florida, USA SO EXPERIMENTAL AND APPLIED ACAROLOGY LA English DT Article DE Ticks; Dog; Cat; Rhipicephalus; Amblyomma; Ixodes; Florida ID WHITE-TAILED DEER; CYTAUXZOON-FELIS; INFECTIOUS-DISEASES; BORNE PATHOGENS; UNITED-STATES; IXODID TICKS; FERAL CATS; PREVALENCE; ACARI; SEROPREVALENCE AB Voluntary collections of ticks from domestic dogs and cats by veterinary practitioners across Florida, USA, were conducted over a 10 month period. Of the 1337 ticks submitted, five species of ixodid ticks were identified and included Rhipicephalus sanguineus, Amblyomma americanum, A. maculatum, Dermacentor variabilis, and Ixodes scapularis. Most ticks were collected from dogs (98.4 %) with the most predominant species being R. sanguineus (94.3 %). Of the ticks collected from cats (1.6 %), A. americanum were the most common (74 %). Only R. sanguineus were collected throughout the state, with the other species collected only in central and north Florida. The tick species collected from dogs and cats represent a risk to these domestic species as well as associated humans for a range of tick-borne diseases in Florida. C1 [Burroughs, Jennifer E.; Greiner, Ellis C.] Univ Florida, Coll Vet Med, Dept Infect Dis & Pathol, Gainesville, FL 32607 USA. [Thomasson, J. Alex] Merial Ltd, Field Vet Serv, Duluth, GA 30096 USA. [Marsella, Rosanna] Univ Florida, Coll Vet Med, Dept Small Anim Clin Sci, Gainesville, FL 32607 USA. [Allan, Sandra A.] USDA ARS, Ctr Med Agr & Vet Entomol, Gainesville, FL 32608 USA. [Burroughs, Jennifer E.] US Army, Med Command, Carlisle, PA 17013 USA. RP Allan, SA (reprint author), USDA ARS, Ctr Med Agr & Vet Entomol, Gainesville, FL 32608 USA. EM sandy.allan@ars.usda.gov NR 50 TC 1 Z9 1 U1 10 U2 21 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0168-8162 EI 1572-9702 J9 EXP APPL ACAROL JI Exp. Appl. Acarol. PD MAY PY 2016 VL 69 IS 1 BP 87 EP 95 DI 10.1007/s10493-016-0019-4 PG 9 WC Entomology SC Entomology GA DI9YJ UT WOS:000373858300008 PM 26888081 ER PT J AU Milanoi, S Ongus, JR Gachara, G Coldren, R Bulimo, W AF Milanoi, Sylvia Ongus, Juliette R. Gachara, George Coldren, Rodney Bulimo, Wallace TI Serotype and genetic diversity of human rhinovirus strains that circulated in Kenya in 2008 SO INFLUENZA AND OTHER RESPIRATORY VIRUSES LA English DT Article DE Diversity; genetic; Kenya; rhinovirus; serotype ID RESPIRATORY-INFECTION; CHILDREN; PNEUMONIA; ILLNESSES; GENOTYPE; IMPACT; JAPAN AB BackgroundHuman rhinoviruses (HRVs) are a well-established cause of the common cold and recent studies indicated that they may be associated with severe acute respiratory illnesses (SARIs) like pneumonia, asthma, and bronchiolitis. Despite global studies on the genetic diversity of the virus, the serotype diversity of these viruses across diverse geographic regions in Kenya has not been characterized. ObjectivesThis study sought to characterize the serotype diversity of HRV strains that circulated in Kenya in 2008. MethodsA total of 517 archived nasopharyngeal samples collected in a previous respiratory virus surveillance program across Kenya in 2008 were selected. Participants enrolled were outpatients who presented with influenza-like (ILI) symptoms. Real-time RT-PCR was employed for preliminary HRV detection. HRV-positive samples were amplified using RT-PCR and thereafter the nucleotide sequences of the amplicons were determined followed by phylogenetic analysis. ResultsTwenty-five percent of the samples tested positive for HRV. Phylogenetic analysis revealed that the Kenyan HRVs clustered into three main species comprising HRV-A (54%), HRV-B (12%), and HRV-C (35%). Overall, 20 different serotypes were identified. Intrastrain sequence homology among the Kenyan strains ranged from 58% to 100% at the nucleotide level and 55% to 100% at the amino acid level. ConclusionThese results show that a wide range of HRV serotypes with different levels of nucleotide variation were present in Kenya. Furthermore, our data show that HRVs contributed substantially to influenza-like illness in Kenya in 2008. C1 [Milanoi, Sylvia; Ongus, Juliette R.] JKUAT, Coll Hlth Sci COHES, Nairobi, Kenya. [Gachara, George] Kenyatta Univ, Dept Med Lab Sci, Nairobi, Kenya. [Coldren, Rodney; Bulimo, Wallace] US Med Res Directorate Kenya, DEID, Nairobi, Kenya. [Coldren, Rodney; Bulimo, Wallace] Walter Reed Army Inst Res, Special Field Act, Silver Spring, MD USA. [Bulimo, Wallace] Univ Nairobi, Dept Biochem, Nairobi, Kenya. RP Bulimo, W (reprint author), POB 606-00621, Nairobi, Kenya. EM Wallace.Bulimo@usamru-k.org RI Bulimo, Wallace/B-1982-2014 OI Bulimo, Wallace/0000-0001-8475-0586 FU US Armed Forces Health Surveillance Center, Division of GEIS Operations FX The authors thank the clinicians who collected the samples and the patients from whom the samples were collected. Ms. Rachel Achilla is acknowledged for laboratory management, Mr. Benjamin Opot and Mr. Silvanos Opanda for nucleotide sequencing and analysis, respectively, and Ms. Finnley Osuna and Meshack Wadegu for technical support and for support of the director, KEMRI. Funding for this study was provided by the US Armed Forces Health Surveillance Center, Division of GEIS Operations. Disclaimer: The views expressed in this work are those of the authors and do not represent those of the US Army Medical Research Directorate-Kenya, Walter Reed Army Institute of Research, the US Army Medical Department, the US Department of the Army, or US Department of Defense. NR 32 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1750-2640 EI 1750-2659 J9 INFLUENZA OTHER RESP JI Influenza Other Respir. Viruses PD MAY PY 2016 VL 10 IS 3 BP 185 EP 191 DI 10.1111/irv.12373 PG 7 WC Infectious Diseases; Virology SC Infectious Diseases; Virology GA DI4SZ UT WOS:000373490900006 PM 26822469 ER PT J AU Bravo, L Wijeyakulasuriya, S Pomraning, E Senecal, PK Kweon, CB AF Bravo, Luis Wijeyakulasuriya, Sameera Pomraning, Eric Senecal, Peter K. Kweon, Chol-Bum TI Large Eddy Simulation of High Reynolds Number Nonreacting and Reacting JP-8 Sprays in a Constant Pressure Flow Vessel With a Detailed Chemistry Approach SO JOURNAL OF ENERGY RESOURCES TECHNOLOGY-TRANSACTIONS OF THE ASME LA English DT Article ID IGNITION; MODEL; FUEL AB In military propulsion applications, the characterization of internal combustion engines operating with jet fuel is vital to understand engine performance, combustion phasing, and emissions when JP-8 is fully substituted for diesel fuel. In this work, high-resolution large eddy simulation (LES) simulations have been performed in-order to provide a comprehensive analysis of the detailed mixture formation process in engine sprays for nozzle configurations of interest to the Army. The first phase examines the behavior of a non-reacting evaporating spray, and demonstrates the accuracy in predicting liquid and vapor transient penetration profiles using a multirealization statistical grid-converged approach. The study was conducted using a suite of single-orifice injectors ranging from 40 to 147 mu m at a rail pressure of 1000 bar and chamber conditions at 900K and 60 bar. The next phase models the nonpremixed combustion behavior of reacting sprays and investigates the submodel ability to predict auto-ignition and lift-off length (LOL) dynamics. The model is constructed using a Kelvin Helmholtz-Rayleigh Taylor (KH-RT) spray atomization framework coupled to an LES approach. The liquid physical properties are defined using a JP-8 mixture containing 80% n-decane and 20% trimethylbenzene (TMB), while the gas phase utilizes the Aachen kinetic mechanism (Hummer, et al., 2007, "Experimental and Kinetic Modeling Study of Combustion of JP-8, Its Surrogates, and Reference Components in Laminar Non Premixed Flows,"Proc. Combust. Inst., 31, pp. 393-400 and Honnet, et al., 2009, "A Surrogate Fuel for Kerosene," Proc. Combust. Inst., 32, pp. 485-492) and a detailed chemistry combustion approach. The results are in good agreement with the spray combustion measurements from the Army Research Laboratory (ARL), constant pressure flow (CPF) facility, and provide a robust computational framework for further JP-8 studies of spray combustion. C1 [Bravo, Luis] US Army, Res Lab, Mem ASME, Vehicle Technol Directorate, 4603 Flare Loop Dr, Aberdeen Proving Ground, MD 21005 USA. [Wijeyakulasuriya, Sameera; Pomraning, Eric; Senecal, Peter K.] Convergent Sci Inc, Mem ASME, 6400 Enterprise Ln, Madison, WI 53719 USA. [Kweon, Chol-Bum] US Army, Res Lab, Vehicle Technol Directorate, 4603 Flare Loop Dr, Aberdeen Proving Ground, MD 21005 USA. RP Bravo, L (reprint author), US Army, Res Lab, Mem ASME, Vehicle Technol Directorate, 4603 Flare Loop Dr, Aberdeen Proving Ground, MD 21005 USA. EM luis.g.bravo2.civ@mail.mil; sameera.wijeyakulasuriya@convergecfd.com; pomraning@convergecfd.com; senecal@convergecfd.com; chol-bum.m.kweon2.civ@mail.mil FU DoD High Performance Computing Modernization Program (HPCMP) FRONTIER Award FX This work was supported in part by resources from the DoD High Performance Computing Modernization Program (HPCMP) FRONTIER Award. The Army project is titled "Petascale High Fidelity Simulation of Atomization and Spray/Wall Interactions at Diesel Engine Conditions." NR 32 TC 0 Z9 0 U1 3 U2 8 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0195-0738 J9 J ENERG RESOUR-ASME JI J. Energy Resour. Technol.-Trans. ASME PD MAY PY 2016 VL 138 IS 3 AR 032207 DI 10.1115/1.4032901 PG 12 WC Energy & Fuels SC Energy & Fuels GA DI7UO UT WOS:000373707700013 ER PT J AU Scenna, R Gupta, AK AF Scenna, Richard Gupta, Ashwani K. TI Preheats Effects on JP8 Reforming Under Volume Distributed Reaction Conditions SO JOURNAL OF ENERGY RESOURCES TECHNOLOGY-TRANSACTIONS OF THE ASME LA English DT Article ID SOOT FORMATION; COMBUSTION; FUELS AB Conventional noncatalytic fuel reforming provides low efficiency, large amounts of char and tar and limited control on chemical composition of the syngas produced. The distributed reaction regime can be used to assist noncatalytic reforming. In this paper, volume distributed reaction technique is used to enhance reformate quality as compared to conventional noncatalytic reforming. This work examines the intermediate regimes between volume distributed reaction and conventional flame to reform JP8 with focus on the chemical and mixing time scales. Chemical time scales were controlled with air preheat temperatures while the mixing time scales were kept constant. Progressive shift toward distributed reaction regime resulted in higher quality reformate with increased amounts of hydrogen and carbon monoxide in the syngas, but with reduced acetylene concentrations and soot formation. Visible soot formation was observed on reactor walls only under the flamelets in eddies regime. Higher hydrogen and carbon monoxide without any catalyst for JP8 reformation offers significant advantages on cost-effective plant operation, reliability, and high yields of syngas. Air preheats of 600, 630, and 660 degrees C showed a distributed reaction regime wherein the Damkohler number was below the Damkohler criterion, and this condition provided high H-2 and CO yields and no soot. At temperature of 690 degrees C, laminar flame thickness approximated the integral length scale (at the interface of distributed and traditional reforming flame) showed minor soot formation. At even higher temperature of 750 degrees C, conventional reforming occurred with increased soot observed. C1 [Scenna, Richard] US Army, CERDEC CPI, Aberdeen Proving Ground, MD USA. [Gupta, Ashwani K.] Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA. RP Gupta, AK (reprint author), Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA. EM akgupta@umd.edu FU United States Army's Research Development Engineering Command Independent Laboratory Innovative Research program FX The authors acknowledge the support of United States Army's Research Development Engineering Command Independent Laboratory Innovative Research program. The authors also gratefully acknowledge the help and support provided by Reaction Design for the Chemkin code used here. This material is declared a work of the U.S. Government and is not subject to copyright protection in the United States. Approved for public release; distribution is unlimited. NR 28 TC 0 Z9 0 U1 0 U2 0 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0195-0738 J9 J ENERG RESOUR-ASME JI J. Energy Resour. Technol.-Trans. ASME PD MAY PY 2016 VL 138 IS 3 AR 032202 DI 10.1115/1.4032140 PG 6 WC Energy & Fuels SC Energy & Fuels GA DI7UO UT WOS:000373707700008 ER PT J AU Cordero, ZC Carpenter, RR Schuh, CA Schuster, BE AF Cordero, Zachary C. Carpenter, Ryan R. Schuh, Christopher A. Schuster, Brian E. TI Sub-scale ballistic testing of an ultrafine grained tungsten alloy into concrete targets SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE Ultrafine grained; Tungsten; Rigid body penetration; Concrete; Penetrator materials ID SPHERICAL CAVITY-EXPANSION; NOSE STEEL PROJECTILES; PENETRATION DEPTH; DECELERATION; RODS AB Ultrafine grained tungsten-based alloys are promising kinetic energy penetrator materials because of their high strengths and densities, making them ideal for penetration into concrete and geomaterials. However, there are difficulties in evaluating their ballistic performance using traditional testing techniques because ultrafine grain sizes are challenging to achieve in bulk parts. In this letter, we performed sub-scale ballistic experiments where ultrafine tungsten alloy cores were fired into concrete targets using small caliber projectile assemblies. The results suggest that sub-scale testing may be used as a screening tool for advanced kinetic energy penetrator materials that are more easily prepared in smaller geometries. Published by Elsevier Ltd. C1 [Cordero, Zachary C.; Schuh, Christopher A.] MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA. [Carpenter, Ryan R.] US Army, Armament Res Dev Engn Ctr, Picatinny Arsenal, NJ 07806 USA. [Schuster, Brian E.] Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Schuster, BE (reprint author), Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM brian.e.schuster.civ@mail.mil FU U.S. Army Research Office through the Institute for Solider Nanotechnologies at MIT [W911NF-14-1-0539]; US Defense Threat Reduction Agency [HDTRA1-11-1-0062]; U.S. Department of Defense through the NDSEG fellowship program FX This work was supported by the U.S. Army Research Office under grant W911NF-14-1-0539 and through the Institute for Solider Nanotechnologies at MIT, and the US Defense Threat Reduction Agency under Grant No. HDTRA1-11-1-0062. ZCC also acknowledges support from the U.S. Department of Defense through the NDSEG fellowship program. The authors thank Dr. Deepak Kapoor of the Picatinny Arsenal and Steven Livers formerly of Boise State University for their assistance in preparing the ultrafine grain tungsten rounds; Dr. Lee Magness of the Army Research Laboratory for advising on the small-caliber testing geometry; and Prof. Emily Huskins for performing high strain rate compression tests on the ultrafine grain tungsten material. NR 19 TC 0 Z9 0 U1 8 U2 17 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X EI 1879-3509 J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD MAY PY 2016 VL 91 BP 1 EP 5 DI 10.1016/j.ijimpeng.2015.11.013 PG 5 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA DH3LY UT WOS:000372689700001 ER PT J AU Sutcliffe, S Nevin, RL Pakpahan, R Elliott, DJ Langston, ME De Marzo, AM Gaydos, CA Isaacs, WB Nelson, WG Sokoll, LJ Walsh, PC Zenilman, JM Cersovsky, SB Platz, EA AF Sutcliffe, Siobhan Nevin, Remington L. Pakpahan, Ratna Elliott, Debra J. Langston, Marvin E. De Marzo, Angelo M. Gaydos, Charlotte A. Isaacs, William B. Nelson, William G. Sokoll, Lori J. Walsh, Patrick C. Zenilman, Jonathan M. Cersovsky, Steven B. Platz, Elizabeth A. TI Infectious mononucleosis, other infections and prostate-specific antigen concentration as a marker of prostate involvement during infection SO INTERNATIONAL JOURNAL OF CANCER LA English DT Article DE infectious mononucleosis; infection; prostate-specific antigen; prostate cancer; epidemiology ID SEXUALLY-TRANSMITTED INFECTIONS; EPSTEIN-BARR-VIRUS; PSA CONCENTRATIONS; LIVER-DISEASE; CANCER; SERUM; HEPATITIS; RISK; HYPERPLASIA; EXPRESSION AB Although Epstein-Barr virus has been detected in prostate tissue, no associations have been observed with prostate cancer in the few studies conducted to date. One possible reason for these null findings may be use of cumulative exposure measures that do not inform the timing of infection, i.e., childhood versus adolescence/early adulthood when infection is more likely to manifest as infectious mononucleosis (IM). We sought to determine the influence of young adult-onset IM on the prostate by measuring prostate-specific antigen (PSA) as a marker of prostate inflammation/damage among U.S. military members. We defined IM cases as men diagnosed with IM from 1998 to 2003 (n=55) and controls as men without an IM diagnosis (n=255). We selected two archived serum specimens for each participant, the first collected after diagnosis for cases and one randomly selected from 1998 to 2003 for controls (index), as well as the preceding specimen (preindex). PSA was measured in each specimen. To explore the specificity of our findings for prostate as opposed to systemic inflammation, we performed a post hoc comparison of other infectious disease cases without genitourinary involvement (n=90) and controls (n=220). We found that IM cases were more likely to have a large PSA rise than controls (20 ng/mL: 19.7% versus 8.8%, p=0.027; 40% rise: 25.7% versus 9.4%, p=0.0021), as were other infectious disease cases (25.7% versus 14.0%, p=0.020; 27.7% versus 18.0%, p=0.092). These findings suggest that, in addition to rising because of prostate infection, PSA may also rise because of systemic inflammation, which could have implications for PSA interpretation in older men. What's new? The discovery of Epstein-Barr virus (EBV) in neoplastic prostate tissue raises questions about the relevance of EBV infection in prostate cancer development. EBV is the major cause of infectious mononucleosis (IM), symptoms of which are most apparent in adolescents and young adults. This study of U.S. military members shows that young-adult (ages 18-25) onset IM is associated with a rise in prostate-specific antigen (PSA) levels during or following infection. Other systemic infections (e.g., influenza) were also linked to increases in PSA. The findings could have implications for the interpretation of PSA screening results. C1 [Sutcliffe, Siobhan; Pakpahan, Ratna] Washington Univ, Sch Med, Dept Surg, Div Publ Hlth Sci, St Louis, MO 63110 USA. [Sutcliffe, Siobhan] Washington Univ, Sch Med, Dept Surg, Alvin J Siteman Canc Ctr, St Louis, MO 63110 USA. [Nevin, Remington L.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mental Hlth, Baltimore, MD USA. [Elliott, Debra J.; De Marzo, Angelo M.; Nelson, William G.; Sokoll, Lori J.] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA. [Langston, Marvin E.] Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Div Epidemiol & Biostat, Tucson, AZ USA. [De Marzo, Angelo M.; Isaacs, William B.; Nelson, William G.; Sokoll, Lori J.; Walsh, Patrick C.; Platz, Elizabeth A.] Johns Hopkins Univ, Sch Med, Dept Urol, Baltimore, MD 21205 USA. [De Marzo, Angelo M.; Isaacs, William B.; Nelson, William G.; Sokoll, Lori J.; Walsh, Patrick C.; Platz, Elizabeth A.] Johns Hopkins Univ, Sch Med, James Buchanan Brady Urol Inst, Baltimore, MD USA. [De Marzo, Angelo M.; Isaacs, William B.; Nelson, William G.; Sokoll, Lori J.; Platz, Elizabeth A.] Sidney Kimmel Comprehens Canc Ctr Johns Hopkins, Baltimore, MD USA. [Gaydos, Charlotte A.; Zenilman, Jonathan M.] Johns Hopkins Univ, Sch Med, Dept Med, Div Infect Dis, Baltimore, MD 21205 USA. [Nelson, William G.] Johns Hopkins Univ, Sch Med, Dept Pharmacol, Baltimore, MD 21205 USA. [Cersovsky, Steven B.] US Army, Publ Hlth Command Provis, Aberdeen, MD USA. [Platz, Elizabeth A.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA. RP Sutcliffe, S (reprint author), Washington Univ, Sch Med, Div Publ Hlth Sci, 600 S Taylor Ave,2nd Floor,Rm 208S,Box 8100, St Louis, MO 63110 USA.; Sutcliffe, S (reprint author), Washington Univ, Sch Med, Alvin J Siteman Canc Ctr, 600 S Taylor Ave,2nd Floor,Rm 208S,Box 8100, St Louis, MO 63110 USA. EM sutcliffes@wudosis.wustl.edu OI Nevin, Remington/0000-0002-0534-1889; Langston, Marvin/0000-0002-4777-2425 FU Fund for Research and Progress in Urology, Johns Hopkins University School of Medicine; Barnes-Jewish Hospital Foundation; Patrick C. Walsh Prostate Cancer Research Fund; National Cancer Institute [P30 CA006973] FX Grant sponsors: Fund for Research and Progress in Urology, Johns Hopkins University School of Medicine; Barnes-Jewish Hospital Foundation; Patrick C. Walsh Prostate Cancer Research Fund; Grant sponsor: National Cancer Institute; Grant number: P30 CA006973 NR 49 TC 0 Z9 0 U1 0 U2 13 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0020-7136 EI 1097-0215 J9 INT J CANCER JI Int. J. Cancer PD MAY 1 PY 2016 VL 138 IS 9 BP 2221 EP 2230 DI 10.1002/ijc.29966 PG 10 WC Oncology SC Oncology GA DF2GY UT WOS:000371161800017 PM 26678984 ER PT J AU Haynes, R Cline, J Shonkwiler, B Armanios, E AF Haynes, Robert Cline, Julia Shonkwiler, Brian Armanios, Erian TI On plane stress and plane strain in classical lamination theory SO COMPOSITES SCIENCE AND TECHNOLOGY LA English DT Article DE Mechanical properties; Elastic properties; Laminate theory ID COMPOSITE-MATERIALS AB Classical Lamination Theory combines the specially orthotropic nature of unidirectional composite plies with the assumptions of Kirchhoff plate theory to arrive at the in-plane properties of the laminate. Traditionally, the derivation assumes a plane stress state in each lamina prior to performing the rotational transformation from the lamina coordinates to the laminate coordinates, resulting in an incomplete formulation of the out-of-plane properties. In this work the rotational transformation of each lamina is performed prior to applying the plane stress or strain simplifications, resulting in an accurate formulation of the out-of-plane properties. Both plane stress and plane strain are considered. To illustrate the new formulation's ability to accurately predict out-of-plane properties, an optimization is performed to find laminates that exhibit the extrema of the out-of-plane Poisson's ratios. Verification of nearly optimal laminates with finite element analysis and experimental testing demonstrates improved accuracy of the new formulation. Published by Elsevier Ltd. C1 [Haynes, Robert] US Army Res Lab, 4603 Flare Loop, Aberdeen Proving Ground, MD 21005 USA. [Cline, Julia; Shonkwiler, Brian; Armanios, Erian] Univ Texas Arlington, Mech & Aerosp Engn, Box 19018, Arlington, TX 76079 USA. RP Haynes, R (reprint author), US Army Res Lab, 4603 Flare Loop, Aberdeen Proving Ground, MD 21005 USA. EM robert.a.haynes43.civ@mail.mil; julia.cline@uta.edu; shonkwil@uta.edu; armanios@uta.edu NR 23 TC 1 Z9 1 U1 2 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0266-3538 EI 1879-1050 J9 COMPOS SCI TECHNOL JI Compos. Sci. Technol. PD APR 28 PY 2016 VL 127 BP 20 EP 27 DI 10.1016/j.compscitech.2016.02.010 PG 8 WC Materials Science, Composites SC Materials Science GA DK1XV UT WOS:000374709700003 ER PT J AU Edmonds, J Lindquist, HDA Sabol, J Martinez, K Shadomy, S Cymet, T Emanuel, P AF Edmonds, Jason Lindquist, H. D. Alan Sabol, Jonathan Martinez, Kenneth Shadomy, Sean Cymet, Tyler Emanuel, Peter TI Multigeneration Cross-Contamination of Mail with Bacillus anthracis Spores SO PLOS ONE LA English DT Article ID BIOTERRORISM-RELATED ANTHRAX; FATAL INHALATIONAL ANTHRAX; UNITED-STATES; OUTBREAK; CONNECTICUT; WASHINGTON; DC AB The release of biological agents, including those which could be used in biowarfare or bioterrorism in large urban areas, has been a concern for governments for nearly three decades. Previous incidents from Sverdlosk and the postal anthrax attack of 2001 have raised questions on the mechanism of spread of Bacillus anthracis spores as an aerosol or contaminant. Prior studies have demonstrated that Bacillus atrophaeus is easily transferred through simulated mail handing, but no reports have demonstrated this ability with Bacillus anthracis spores, which have morphological differences that may affect adhesion properties between spore and formite. In this study, equipment developed to simulate interactions across three generations of envelopes subjected to tumbling and mixing was used to evaluate the potential for cross-contamination of B. anthracis spores in simulated mail handling. In these experiments, we found that the potential for cross-contamination through letter tumbling from one generation to the next varied between generations while the presence of a fluidizer had no statistical impact on the transfer of material. Likewise, the presence or absence of a fluidizer had no statistically significant impact on cross-contamination levels or reaerosolization from letter opening. C1 [Edmonds, Jason; Sabol, Jonathan; Emanuel, Peter] US Army, Dept Def, Edgewood Chem Biol Ctr, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. [Lindquist, H. D. Alan] US EPA, Off Res & Dev, Natl Homeland Secur Res Ctr, 26 West Martin Luther King Dr, Cincinnati, OH 45268 USA. [Martinez, Kenneth] HWC Inc, 1100 New York Ave NW, Washington, DC 20005 USA. [Shadomy, Sean] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, 1600 Clifton Rd,MS A-30, Atlanta, GA 30333 USA. [Cymet, Tyler] Amer Assoc Coll Osteopath Med, Med Educ, Chevy Chase, MD 20815 USA. RP Edmonds, J (reprint author), US Army, Dept Def, Edgewood Chem Biol Ctr, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM jason.m.edmonds2.civ@mail.mil FU Combatting Terrorism Technical Support Working Group, Caution; Hassett Willis; Department of Defense; Edgewood Chemical Biological Center; Department of Health and Human Services Centers for Disease Control and Prevention; National Institutes for Occupational Safety and Health; Department of Justice; Federal Bureau of Investigations; U.S. Environmental Protection Agency through its Office of Research and Development FX This program was partially funded by the Technical Support Working Group, now the Combatting Terrorism Technical Support Working Group, Caution (http://www.cttso.gov/). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Hassett Willis provided support in the form of salaries for authors (KM), but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The Department of Defense, Edgewood Chemical Biological Center, Department of Health and Human Services Centers for Disease Control and Prevention, National Institutes for Occupational Safety and Health, Department of Justice, Federal Bureau of Investigations, and the U.S. Environmental Protection Agency through its Office of Research and Development partially funded and collaborated in the research described here. This manuscript has been subject to Agency review and but does not necessarily reflect the views of the Agencies listed above. The specific roles of these authors are articulated in the author contributions section.; The Department of Defense, Edgewood Chemical Biological Center, Department of Health and Human Services Centers for Disease Control and Prevention, National Institutes for Occupational Safety and Health, Department of Justice, Federal Bureau of Investigations, and the U.S. Environmental Protection Agency through its Office of Research and Development partially funded and collaborated in the research described here. This manuscript has been subject to Agency review and but does not necessarily reflect the views of the Agencies listed above. No official endorsement should be inferred. Mention or use of trade names does not constitute endorsement of recommendation for use. NR 25 TC 0 Z9 0 U1 3 U2 5 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD APR 28 PY 2016 VL 11 IS 4 AR e0152225 DI 10.1371/journal.pone.0152225 PG 13 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DK8XE UT WOS:000375211700004 PM 27123934 ER PT J AU Agnandji, ST Huttner, A Zinser, ME Njuguna, P Dahlke, C Fernandes, JF Yerly, S Dayer, JA Kraehling, V Kasonta, R Adegnika, AA Altfeld, M Auderset, F Bache, EB Biedenkopf, N Borregaard, S Brosnahan, JS Burrow, R Combescure, C Desmeules, J Eickmann, M Fehling, SK Finckh, A Goncalves, AR Grobusch, MP Hooper, J Jambrecina, A Kabwende, AL Kaya, G Kimani, D Lell, B Lemaitre, B Lohse, AW Massinga-Loembe, M Matthey, A Mordmuller, B Nolting, A Ogwang, C Ramharter, M Schmidt-Chanasit, J Schmiedel, S Silvera, P Stahl, FR Staines, HM Strecker, T Stubbe, HC Tsofa, B Zaki, S Fast, P Moorthy, V Kaiser, L Krishna, S Becker, S Kieny, MP Bejon, P Kremsner, PG Addo, MM Siegrist, CA AF Agnandji, S. T. Huttner, A. Zinser, M. E. Njuguna, P. Dahlke, C. Fernandes, J. F. Yerly, S. Dayer, J. -A. Kraehling, V. Kasonta, R. Adegnika, A. A. Altfeld, M. Auderset, F. Bache, E. B. Biedenkopf, N. Borregaard, S. Brosnahan, J. S. Burrow, R. Combescure, C. Desmeules, J. Eickmann, M. Fehling, S. K. Finckh, A. Goncalves, A. R. Grobusch, M. P. Hooper, J. Jambrecina, A. Kabwende, A. L. Kaya, G. Kimani, D. Lell, B. Lemaitre, B. Lohse, A. W. Massinga-Loembe, M. Matthey, A. Mordmueller, B. Nolting, A. Ogwang, C. Ramharter, M. Schmidt-Chanasit, J. Schmiedel, S. Silvera, P. Stahl, F. R. Staines, H. M. Strecker, T. Stubbe, H. C. Tsofa, B. Zaki, S. Fast, P. Moorthy, V. Kaiser, L. Krishna, S. Becker, S. Kieny, M. -P. Bejon, P. Kremsner, P. G. Addo, M. M. Siegrist, C. -A. TI Phase 1 Trials of rVSV Ebola Vaccine in Africa and Europe SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID VESICULAR STOMATITIS-VIRUS; PROTECTS NONHUMAN-PRIMATES; MARBURG VIRUS; INFECTION; IMMUNITY; VSV AB BACKGROUND The replication-competent recombinant vesicular stomatitis virus (rVSV)-based vaccine expressing a Zaire ebolavirus (ZEBOV) glycoprotein was selected for rapid safety and immunogenicity testing before its use in West Africa. METHODS We performed three open-label, dose-escalation phase 1 trials and one randomized, double-blind, controlled phase 1 trial to assess the safety, side-effect profile, and immunogenicity of rVSV-ZEBOV at various doses in 158 healthy adults in Europe and Africa. All participants were injected with doses of vaccine ranging from 300,000 to 50 million plaque-forming units (PFU) or placebo. RESULTS No serious vaccine-related adverse events were reported. Mild-to-moderate early-onset reactogenicity was frequent but transient (median, 1 day). Fever was observed in up to 30% of vaccinees. Vaccine viremia was detected within 3 days in 123 of the 130 participants (95%) receiving 3 million PFU or more; rVSV was not detected in saliva or urine. In the second week after injection, arthritis affecting one to four joints developed in 11 of 51 participants (22%) in Geneva, with pain lasting a median of 8 days (interquartile range, 4 to 87); 2 self-limited cases occurred in 60 participants (3%) in Hamburg, Germany, and Kilifi, Kenya. The virus was identified in one synovial-fluid aspirate and in skin vesicles of 2 other vaccinees, showing peripheral viral replication in the second week after immunization. ZEBOV-glycoprotein-specific antibody responses were detected in all the participants, with similar glycoprotein-binding antibody titers but significantly higher neutralizing antibody titers at higher doses. Glyco-protein-binding antibody titers were sustained through 180 days in all participants. CONCLUSIONS In these studies, rVSV-ZEBOV was reactogenic but immunogenic after a single dose and warrants further evaluation for safety and efficacy. C1 [Siegrist, C. -A.] Univ Hosp Geneva, Ctr Vaccinol, 1 Rue Michel Servet, CH-1211 Geneva 4, Switzerland. [Agnandji, S. T.; Fernandes, J. F.; Adegnika, A. A.; Bache, E. B.; Brosnahan, J. S.; Grobusch, M. P.; Kabwende, A. L.; Lell, B.; Massinga-Loembe, M.; Mordmueller, B.; Ramharter, M.; Krishna, S.; Kremsner, P. G.] Ctr Rech Med Lambarene, Lambarene, Gabon. [Agnandji, S. T.; Fernandes, J. F.; Adegnika, A. A.; Bache, E. B.; Brosnahan, J. S.; Grobusch, M. P.; Kabwende, A. L.; Lell, B.; Massinga-Loembe, M.; Mordmueller, B.; Ramharter, M.; Krishna, S.; Kremsner, P. G.] Univ Klinikum Tubinen, Inst Tropenmed, Tubingen, Germany. [Agnandji, S. T.; Fernandes, J. F.; Adegnika, A. A.; Bache, E. B.; Brosnahan, J. S.; Grobusch, M. P.; Kabwende, A. L.; Lell, B.; Massinga-Loembe, M.; Mordmueller, B.; Ramharter, M.; Krishna, S.; Kremsner, P. G.] German Ctr Infect Res, Tubingen, Germany. [Zinser, M. E.; Dahlke, C.; Kasonta, R.; Lohse, A. W.; Nolting, A.; Schmiedel, S.; Stubbe, H. C.; Addo, M. M.] Univ Med Ctr Hamburg Eppendorf, Dept Med 1, Hamburg, Germany. [Stahl, F. R.] Inst Clin Chem & Lab Med, Hamburg, Germany. [Dahlke, C.; Nolting, A.; Schmidt-Chanasit, J.; Stubbe, H. C.; Addo, M. M.] German Ctr Infect Res, Partner Site Standort Hamburg lUBECK Borstel, Hamburg, Germany. [Altfeld, M.] Leibniz Inst Expt Virol, Heinrich Pette Inst, Hamburg, Germany. [Borregaard, S.; Jambrecina, A.] Clin Trial Ctr North, Hamburg, Germany. [Schmidt-Chanasit, J.] WHO, Collaborating Ctr Arbovirus & Hemorrhag Fever Ref, Natl Reference Ctr Trop Infect Dis, Bernhard Nocht Inst Trop Med, Hamburg, Germany. [Kraehling, V.; Biedenkopf, N.; Eickmann, M.; Fehling, S. K.; Strecker, T.; Becker, S.] Univ Marburg, Inst Virol, Partner Site Giessen Marburg Langen, D-35032 Marburg, Germany. [Kraehling, V.; Biedenkopf, N.; Eickmann, M.; Fehling, S. K.; Strecker, T.; Becker, S.] German Ctr Infect Res DZIF, Partner Site Giessen Marburg Langen, Marburg, Germany. [Kasonta, R.] Paul Ehrlich Inst, Div Vet Med, Langen, Germany. [Huttner, A.] Univ Hosp Geneva, Infect Control Program, CH-1211 Geneva 4, Switzerland. [Huttner, A.; Dayer, J. -A.; Kaiser, L.] Univ Hosp Geneva, Div Infect Dis, CH-1211 Geneva 4, Switzerland. [Combescure, C.] Univ Hosp Geneva, Div Clin Epidemiol, CH-1211 Geneva 4, Switzerland. [Finckh, A.] Univ Hosp Geneva, Div Rheumatol, CH-1211 Geneva 4, Switzerland. [Kaya, G.] Univ Hosp Geneva, Div Dermatol, CH-1211 Geneva 4, Switzerland. [Desmeules, J.; Matthey, A.] Univ Hosp Geneva, Clin Res Ctr, CH-1211 Geneva 4, Switzerland. [Yerly, S.; Goncalves, A. R.; Kaiser, L.] Univ Hosp Geneva, Fac Med, CH-1211 Geneva 4, Switzerland. [Yerly, S.; Goncalves, A. R.; Kaiser, L.] Univ Hosp Geneva, Virol Lab, CH-1211 Geneva 4, Switzerland. [Auderset, F.; Lemaitre, B.; Siegrist, C. -A.] WHO, Collaborat Ctr Vaccinol, Fac Med, Geneva, Switzerland. [Fast, P.; Moorthy, V.; Kieny, M. -P.] WHO, Geneva, Switzerland. [Njuguna, P.; Kimani, D.; Ogwang, C.; Tsofa, B.; Bejon, P.] Ctr Geog Med Res, Kenya Med Res Inst, Wellcome Trust Res Program, Kilifi, Kenya. [Adegnika, A. A.] Leiden Univ, Dept Parasitol, Med Ctr, Leiden, Netherlands. [Grobusch, M. P.] Univ Amsterdam, Acad Med Ctr, Ctr Trop Med & Travel Med, Dept Infect Dis,Div Internal Med, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands. [Burrow, R.; Staines, H. M.; Krishna, S.] Univ London, Inst Infect & Immun, London WC1E 7HU, England. [Hooper, J.; Silvera, P.] US Army, Dept Mol Virol, Med Res Inst Infect, Frederick, MD USA. [Hooper, J.; Silvera, P.] US Army, Div Translat Sci, Med Res Inst Infect, Frederick, MD USA. [Ramharter, M.] Med Univ Vienna, Dept Med 1, Div Infect Dis & Trop Med, Vienna, Austria. [Zaki, S.] Ctr Dis Control & Prevent, Infect Dis Pathol Branch, Atlanta, GA USA. [Fast, P.] Int AIDS Vaccine Initiat, New York, NY USA. RP Addo, MM (reprint author), Univ Med Ctr Hamburg Eppendorf, Dept Med 1, Div Trop Med, Martinistr 52, D-20246 Hamburg, Germany.; Siegrist, CA (reprint author), Univ Hosp Geneva, Ctr Vaccinol, 1 Rue Michel Servet, CH-1211 Geneva 4, Switzerland.; Siegrist, CA (reprint author), Ctr Med Univ Geneva, Fac Med, 1 Rue Michel Servet, CH-1211 Geneva 4, Switzerland. EM m.addo@uke.de; claire-anne.siegrist@unige.ch RI Staines, Henry/B-6281-2009; Ramharter, Michael/C-5273-2013 OI Staines, Henry/0000-0001-5890-3040; Ramharter, Michael/0000-0002-9259-1885 FU Wellcome Trust FX Funded by the Wellcome Trust and others; ClinicalTrials.gov numbers, NCT02283099, NCT02287480, and NCT02296983; Pan African Clinical Trials Registry number, PACTR201411000919191. NR 32 TC 61 Z9 62 U1 21 U2 44 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 EI 1533-4406 J9 NEW ENGL J MED JI N. Engl. J. Med. PD APR 28 PY 2016 VL 374 IS 17 BP 1647 EP 1660 DI 10.1056/NEJMoa1502924 PG 14 WC Medicine, General & Internal SC General & Internal Medicine GA DK3UR UT WOS:000374843400008 PM 25830326 ER PT J AU Timmerwilke, J Liou, SH Cheng, SF Edelstein, AS AF Timmerwilke, John Liou, Sy-Hwang Cheng, Shu Fan Edelstein, Alan S. TI Rewriting magnetic phase change memory by laser heating SO JOURNAL OF PHYSICS D-APPLIED PHYSICS LA English DT Article DE memory; phase change; magnetic ID THIN-FILMS; CRYSTALLIZATION AB Magnetic phase change memory (MAG PCM) consists of bits with different magnetic permeability values. The bits are read by measuring their effect on a magnetic probe field. Previously low permeability crystalline bits had been written in high permeability amorphous films of Metglas via laser heating. Here data is presented showing that by applying short laser pulses with the appropriate power to previously crystallized regions they can first be vitrified and then again crystallized. Thus, MAG PCM is rewriteable. Technical issues in processing the bits are discussed and results on thermal modeling are presented. C1 [Timmerwilke, John; Edelstein, Alan S.] US Army Res Lab, Adelphi, MD 20783 USA. [Liou, Sy-Hwang] Univ Nebraska, Dept Phys & Astron, Lincoln, NE 68588 USA. [Cheng, Shu Fan] Naval Res Lab, Washington, DC 20375 USA. RP Timmerwilke, J (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. NR 17 TC 0 Z9 0 U1 4 U2 9 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0022-3727 EI 1361-6463 J9 J PHYS D APPL PHYS JI J. Phys. D-Appl. Phys. PD APR 27 PY 2016 VL 49 IS 16 AR 165005 DI 10.1088/0022-3727/49/16/165005 PG 6 WC Physics, Applied SC Physics GA DI6PV UT WOS:000373622900006 ER PT J AU Govindarajan, V Rakesh, V Reifman, J Mitrophanov, AY AF Govindarajan, Vijay Rakesh, Vineet Reifman, Jaques Mitrophanov, Alexander Y. TI Computational Study of Thrombus Formation and Clotting Factor Effects under Venous Flow Conditions SO BIOPHYSICAL JOURNAL LA English DT Article ID PROTHROMBIN COMPLEX CONCENTRATE; SURFACE-MEDIATED CONTROL; BLOOD-COAGULATION; PLATELET DEPOSITION; TISSUE FACTOR; FIBRINOGEN CONCENTRATE; IN-VIVO; HYDRAULIC PERMEABILITY; INTRALUMINAL THROMBUS; MULTISCALE MODEL AB A comprehensive understanding of thrombus formation as a physicochemical process that has evolved to protect the integrity of the human vasculature is critical to our ability to predict and control pathological states caused by a malfunctioning blood coagulation system. Despite numerous investigations, the spatial and temporal details of thrombus growth as a multicomponent process are not fully understood. Here, we used computational modeling to investigate the temporal changes in the spatial distributions of the key enzymatic (i.e., thrombin) and structural (i.e., platelets and fibrin) components within a growing thrombus. Moreover, we investigated the interplay between clot structure and its mechanical properties, such as hydraulic resistance to flow. Our model relied on the coupling of computational fluid dynamics and biochemical kinetics, and was validated using flow-chamber data from a previous experimental study. The model allowed us to identify the distinct patterns characterizing the spatial distributions of thrombin, platelets, and fibrin accumulating within a thrombus. Our modeling results suggested that under the simulated conditions, thrombin kinetics was determined predominantly by prothrombinase. Furthermore, our simulations showed that thrombus resistance imparted by fibrin was similar to 30-fold higher than that imparted by platelets. Yet, thrombus-mediated bloodflow occlusion was driven primarily by the platelet deposition process, because the height of the platelet accumulation domain was approximately twice that of the fibrin accumulation domain. Fibrinogen supplementation in normal blood resulted in a nonlinear increase in thrombus resistance, and for a supplemented fibrinogen level of 48%, the thrombus resistance increased by similar to 2.7-fold. Finally, our model predicted that restoring the normal levels of clotting factors II, IX, and X while simultaneously restoring fibrinogen (to 88% of its normal level) in diluted blood can restore fibrin generation to similar to 78% of its normal level and hence improve clot formation under dilution. C1 [Govindarajan, Vijay; Rakesh, Vineet; Reifman, Jaques; Mitrophanov, Alexander Y.] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Biotechnol High Performance Comp Software Applica, Dept Def, Ft Detrick, MD USA. RP Reifman, J (reprint author), US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Biotechnol High Performance Comp Software Applica, Dept Def, Ft Detrick, MD USA. EM jaques.reifman.civ@mail.mil FU U.S. Army Network Science Initiative, U.S. Army Medical Research and Materiel Command, Fort Detrick, MD FX This work was supported by the U.S. Army Network Science Initiative, U.S. Army Medical Research and Materiel Command, Fort Detrick, MD. High-performance computing resources were made available by the U.S. Department of Defense High Performance Computing Modernization Program. NR 97 TC 1 Z9 1 U1 2 U2 5 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 0006-3495 EI 1542-0086 J9 BIOPHYS J JI Biophys. J. PD APR 26 PY 2016 VL 110 IS 8 BP 1869 EP 1885 DI 10.1016/j.bpj.2016.03.010 PG 17 WC Biophysics SC Biophysics GA DK4AV UT WOS:000374859600020 PM 27119646 ER PT J AU Wang, YW Im, JS Soares, JW Steeves, DM Whitten, JE AF Wang, Yiwen Im, Jisun Soares, Jason W. Steeves, Diane M. Whitten, James E. TI Thiol Adsorption on and Reduction of Copper Oxide Particles and Surfaces SO LANGMUIR LA English DT Article ID SELF-ASSEMBLED MONOLAYERS; SENSITIZED SOLAR-CELLS; METAL-OXIDES; ELECTRONIC-PROPERTIES; CORROSION INHIBITION; OXIDATION; CU2O; ALKANETHIOLS; CU(111); OXYGEN AB The adsorption of 1-dodecanethiol at room temperature and at 75 degrees C on submicron cuprous and cupric oxide particles suspended in ethanol has been investigated by X-ray photoelectron spectroscopy (XPS), Raman spectroscopy, and transmission electron microscopy. Thiol adsorption occurs in all cases via Cu-S bond formation, with partial dissolution of CuO at 75 degrees C and formation of a copper thiolate complex replacement layer. Regardless of temperature, the surface of the CuO particles is essentially completely reduced to either Cu2O or metallic copper, as evidenced by loss of the characteristic Cu2+ XPS features of dried powder samples. Companion ultrahigh-vacuum studies have been performed by dosing clean, oxygen-dosed, and ozone-treated single crystal Cu(111) with methanethiol (MT) gas at room temperature. In the latter case, the surface corresponds to CuO/Cu(111). XPS confirms MT adsorption in all cases, with an S 2p peak binding energy of 162.9 +/- 0.1 eV, consistent with methanethiolate adsorption. Heating of MT-covered Cu(111) and oxygen-dosed Cu(111) leads to decomposition/desorption of the MT by 100 degrees C and formation of copper sulfide with an S 2p binding energy of 161.8 eV. Dosing CuO/Cu(111) with 50-200 L of MT leads to only partial reduction/removal of the CuO surface layers prior to methanethiolate adsorption. This is confirmed by ultraviolet photoelectron spectroscopy (UPS), which measures the occupied states near the Fermi level. For both the colloidal CuO and single crystal CuO/Cu(111) studies, the reduction of the Cu2+ surface is believed to occur by formation and desorption of the corresponding dithiol prior to thiolate adsorption. C1 [Wang, Yiwen; Im, Jisun; Whitten, James E.] Univ Massachusetts, Dept Chem, Lowell, MA 01854 USA. [Soares, Jason W.; Steeves, Diane M.] US Army, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Whitten, JE (reprint author), Univ Massachusetts, Dept Chem, Lowell, MA 01854 USA. EM James_Whitten@uml.edu FU U.S. Army Natick Soldier Research, Development, and Engineering Center [W911QY-13-2-003] FX The authors acknowledge the assistance of Dr. Peng Wang at Bruker Optics in obtaining the Raman spectra. This work is supported by U.S. Army Natick Soldier Research, Development, and Engineering Center, under Cooperative Agreement #W911QY-13-2-003. The authors also acknowledge an equipment donation of the ozone generator from MKS, Inc. NR 38 TC 4 Z9 4 U1 15 U2 36 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0743-7463 J9 LANGMUIR JI Langmuir PD APR 26 PY 2016 VL 32 IS 16 BP 3848 EP 3857 DI 10.1021/acs.langmuir.6b00651 PG 10 WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA DK9IE UT WOS:000375243300006 PM 27036074 ER PT J AU Torrisi, SB Britton, JW Bohnet, JG Bollinger, JJ AF Torrisi, Steven B. Britton, Joseph W. Bohnet, Justin G. Bollinger, John J. TI Perpendicular laser cooling with a rotating-wall potential in a Penning trap SO PHYSICAL REVIEW A LA English DT Article ID NONNEUTRAL PLASMAS; ION PLASMAS; CRYSTALS AB We investigate the impact of a rotating-wall potential on perpendicular laser cooling in a Penning ion trap. By including energy exchange with the rotating wall, we extend previous Doppler laser-cooling theory and show that low perpendicular temperatures are more readily achieved with a rotating wall than without. Detailed numerical studies determine optimal operating parameters for producing low-temperature, stable two-dimensional crystals, important for quantum information processing experiments employing Penning traps. C1 [Torrisi, Steven B.; Britton, Joseph W.; Bohnet, Justin G.; Bollinger, John J.] NIST, Boulder, CO 80305 USA. [Torrisi, Steven B.] Univ Rochester, Dept Phys & Astron, Rochester, NY 14627 USA. [Britton, Joseph W.] US Army Res Lab, Adelphi, MD 20783 USA. RP Torrisi, SB (reprint author), NIST, Boulder, CO 80305 USA.; Torrisi, SB (reprint author), Univ Rochester, Dept Phys & Astron, Rochester, NY 14627 USA. FU Summer Undergraduate Research Fellowship through NIST; NIST NRC postdoctoral fellowship FX We acknowledge useful discussions with D. H. E. Dubin, R. C. Thompson, A. Keith, and D. Meiser. We thank K. Gilmore and R. Fox for their comments on the manuscript. S.B.T. was supported by Summer Undergraduate Research Fellowship funding through NIST. J.G.B. was supported by a NIST NRC postdoctoral fellowship. This manuscript is a contribution of NIST and not subject to U.S. copyright. NR 25 TC 1 Z9 1 U1 4 U2 4 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2469-9926 EI 2469-9934 J9 PHYS REV A JI Phys. Rev. A PD APR 26 PY 2016 VL 93 IS 4 AR 043421 DI 10.1103/PhysRevA.93.043421 PG 8 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA DK4ZJ UT WOS:000374928600012 ER PT J AU Ingersoll, T Cole, S Madren-Whalley, J Booker, L Dorsey, R Li, A Salem, H AF Ingersoll, Thomas Cole, Stephanie Madren-Whalley, Janna Booker, Lamont Dorsey, Russell Li, Albert Salem, Harry TI Generalized Additive Mixed-Models for Pharmacology Using Integrated Discrete Multiple Organ Co-Culture SO PLOS ONE LA English DT Article ID CYTOTOXIC METABOLITES; LINEAR-MODELS; CYCLOPHOSPHAMIDE; INSECTICIDES; HEPATOCYTES; MOUSE AB Integrated Discrete Multiple Organ Co-culture (IDMOC) is emerging as an in-vitro alternative to in-vivo animal models for pharmacology studies. IDMOC allows dose-response relationships to be investigated at the tissue and organoid levels, yet, these relationships often exhibit responses that are far more complex than the binary responses often measured in whole animals. To accommodate departure from binary endpoints, IDMOC requires an expansion of analytic techniques beyond simple linear probit and logistic models familiar in toxicology. IDMOC dose-responses may be measured at continuous scales, exhibit significant non-linearity such as local maxima or minima, and may include non-independent measures. Generalized additive mixed-modeling (GAMM) provides an alternative description of dose-response that relaxes assumptions of independence and linearity. We compared GAMMs to traditional linear models for describing dose-response in IDMOC pharmacology studies. C1 [Ingersoll, Thomas] Def Threat Reduct Agcy, Joint CBRN Ctr Excellence, Aberdeen Proving Ground, MD USA. [Cole, Stephanie; Madren-Whalley, Janna; Dorsey, Russell; Salem, Harry] US Army Res Dev & Engn Command, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA. [Booker, Lamont] US FDA, Silver Spring, MD USA. [Li, Albert] In Vitro ADMET Labs, Columbia, MD USA. RP Ingersoll, T (reprint author), Def Threat Reduct Agcy, Joint CBRN Ctr Excellence, Aberdeen Proving Ground, MD USA. EM thomas.e.ingersoll.civ@mail.mil FU ADMET Laboratories; Defense Threat Reduction Agency; US Army Research, Development, and Engineering Command; National Research Council, Research Associate Program FX The authors received no specific funding for this work, other than support in the form of authors' salaries. One co-author (AL) is employed by a commercial company: ADMET Laboratories. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials. ADMET Laboratories provided support in the form of salary for co-author AL, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the 'author contributions' section.; The authors would like to thank the Defense Threat Reduction Agency, the US Army Research, Development, and Engineering Command, and the National Research Council, Research Associate Program for sponsoring this research. NR 27 TC 0 Z9 0 U1 2 U2 6 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD APR 25 PY 2016 VL 11 IS 4 AR e0152985 DI 10.1371/journal.pone.0152985 PG 12 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DK5OX UT WOS:000374970600008 PM 27110941 ER PT J AU DeMar, J Sharrow, K Hill, M Berman, J Oliver, T Long, J AF DeMar, James Sharrow, Keith Hill, Miya Berman, Jonathan Oliver, Thomas Long, Joseph TI Effects of Primary Blast Overpressure on Retina and Optic Tract in Rats SO FRONTIERS IN NEUROLOGY LA English DT Article DE blast; neurotrauma; retina; optic tract; rat ID TRAUMATIC BRAIN-INJURY; INDUCED OCULAR TRAUMA; MOUSE MODEL; AFGHANISTAN WARS; DEGENERATION; TBI; DAMAGE; EYE; PATHOPHYSIOLOGY; MECHANISMS AB Blast has been the leading cause of injury, particularly traumatic brain injury and visual system injury, in combat operations in Iraq and Afghanistan. We determined the effect of shock tube-generated primary blast on retinal electrophysiology and on retinal and brain optic tract histopathology in a rat model. The amplitude of a- and b-waves on the electroretinogram (ERG) for both right and left eyes were measured prior to a battlefield simulation Friedlander-type blast wave and on 1, 7, and 14 days thereafter. Histopathologic findings of the right and left retina and the right and left optic tracts (2.8 mm postoptic chiasm) were evaluated 14 days after the blast. For two experiments in which the right eye was oriented to the blast, the amplitude of ERG a- and b-waves at 7 days post blast on the right side but not on the left side was diminished compared to that of sham animals (P = 0.005-0.01) Histopathologic injury scores at 14 days post blast for the right retina but not the left retina were higher than for sham animals (P = 0.01), and histopathologic injury scores at 14 days for both optic tracts were markedly higher than for shams (P < 0.0001). Exposure of one eye to a blast wave, comparable to that causing human injury, produced injury to the retina as determined by ERG and histopathology, and to both postchiasmatic optic tracts as determined by histopathology. This model may be useful for analyzing the effect of therapeutic interventions on retinal damage due to primary blast waves. C1 [DeMar, James; Hill, Miya; Long, Joseph] Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA. [Sharrow, Keith] Med Countermeasures Syst, Frederick, MD USA. [Berman, Jonathan] Walter Reed Army Inst Res, Dept Clin Pharmacol, Silver Spring, MD USA. [Oliver, Thomas] Uniformed Serv Univ Hlth Sci, Clin Res Unit, Bethesda, MD 20814 USA. RP DeMar, J (reprint author), Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA. EM james.c.demar.ctr@mail.mil FU USAMRMC/TATRC Vision Research Program [W81XWH-12-2-0082] FX This work was supported in part by a USAMRMC/TATRC Vision Research Program grant award, #: W81XWH-12-2-0082. NR 32 TC 0 Z9 0 U1 7 U2 7 PU FRONTIERS MEDIA SA PI LAUSANNE PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLAND SN 1664-2295 J9 FRONT NEUROL JI Front. Neurol. PD APR 25 PY 2016 VL 7 AR 59 DI 10.3389/fneur.2016.00059 PG 12 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA DK0WV UT WOS:000374633800001 PM 27199884 ER PT J AU Dye, JM Wu, H Hooper, JW Khurana, S Kuehne, AI Coyle, EM Ortiz, RA Fuentes, S Herbert, AS Golding, H Bakken, RA Brannan, JM Kwilas, SA Sullivan, EJ Luke, TC Smith, G Glenn, G Li, WF Ye, L Yang, CL Compans, RW Tripp, RA Jiao, JA AF Dye, John M. Wu, Hua Hooper, Jay W. Khurana, Surender Kuehne, Ana I. Coyle, Elizabeth M. Ortiz, Ramon A. Fuentes, Sandra Herbert, Andrew S. Golding, Hana Bakken, Russell A. Brannan, Jennifer M. Kwilas, Steve A. Sullivan, Eddie J. Luke, Thomas C. Smith, Gale Glenn, Gregory Li, Wenfang Ye, Ling Yang, Chinglai Compans, Richard W. Tripp, Ralph A. Jiao, Jin-an TI Production of Potent Fully Human Polyclonal Antibodies against Ebola Zaire Virus in Transchromosomal Cattle SO SCIENTIFIC REPORTS LA English DT Article ID HEMORRHAGIC-FEVER; NONHUMAN-PRIMATES; INFECTION; PROPHYLAXIS; PROTECTION; DISEASE; ZMAPP AB Polyclonal antibodies, derived from humans or hyperimmunized animals, have been used prophylactically or therapeutically as countermeasures for a variety of infectious diseases. SAB Biotherapeutics has successfully developed a transchromosomic (Tc) bovine platform technology that can produce fully human immunoglobulins rapidly, and in substantial quantities, against a variety of disease targets. In this study, two Tc bovines expressing high levels of fully human IgG were hyperimmunized with a recombinant glycoprotein (GP) vaccine consisting of the 2014 Ebola virus (EBOV) Makona isolate. Serum collected from these hyperimmunized Tc bovines contained high titers of human IgG against EBOV GP as determined by GP specific ELISA, surface plasmon resonance (SPR), and virus neutralization assays. Fully human polyclonal antibodies against EBOV were purified and evaluated in a mouse challenge model using mouse adapted Ebola virus (maEBOV). Intraperitoneal administration of the purified anti-EBOV IgG (100 mg/kg) to BALB/c mice one day after lethal challenge with maEBOV resulted in 90% protection; whereas 100% of the control animals succumbed. The results show that hyperimmunization of Tc bovines with EBOV GP can elicit protective and potent neutralizing fully human IgG antibodies rapidly and in commercially viable quantities. C1 [Dye, John M.; Kuehne, Ana I.; Ortiz, Ramon A.; Herbert, Andrew S.; Bakken, Russell A.; Brannan, Jennifer M.; Kwilas, Steve A.] US Army Med Res Inst Infect Dis, Virol Div, Ft Detrick, MD USA. [Wu, Hua; Sullivan, Eddie J.; Jiao, Jin-an] SAB Biotherapeut, Sioux Falls, SD USA. [Khurana, Surender; Coyle, Elizabeth M.; Fuentes, Sandra; Golding, Hana] US FDA, Div Viral Prod, CBER, Silver Spring, MD USA. [Luke, Thomas C.] Henry Jackson Fdn, Viral & Rickettsial Dis Dept, Navy Med Res Ctr, Silver Spring, MD USA. [Smith, Gale; Glenn, Gregory] Novavax Inc, Gaithersburg, MD USA. [Li, Wenfang; Ye, Ling; Yang, Chinglai; Compans, Richard W.] Emory Univ, Dept Microbiol & Immunol, Atlanta, GA 30322 USA. [Li, Wenfang; Ye, Ling; Yang, Chinglai; Compans, Richard W.] Emory Univ, Emory Vaccine Ctr, Atlanta, GA 30322 USA. [Tripp, Ralph A.] Univ Georgia, Athens, GA 30602 USA. RP Jiao, JA (reprint author), SAB Biotherapeut, Sioux Falls, SD USA. EM jjiao@sabbiotherapeutics.com OI Hooper, Jay/0000-0002-4475-0415 FU SAB Biotherapeutics, Inc; Novavax, Inc.; Viral and Rickettsial Diseases Department of the Naval Medical Research Center (VRDD, NMRC); Henry Jackson Foundation for the Advancement of Military Medicine; US Navy [Omnibus III DO-0005] FX This work was funded in part by SAB Biotherapeutics, Inc and Novavax, Inc. Financial interest in this work is currently owned by SAB Biotherapeutics, Inc, and Novavax, Inc. who did have a role in the decision to publish as well as the preparation of the manuscript. While it is considered beneficial to the interests of SAB Biotherapeutics, Inc and Novavax, Inc. to publish this work, this consideration played no role in the study design, data collection and analysis and preparation of the manuscript. This project was supported in part by the Viral and Rickettsial Diseases Department of the Naval Medical Research Center (VRDD, NMRC) and The Henry Jackson Foundation for the Advancement of Military Medicine contract with the US Navy (Contract # Omnibus III DO-0005). The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Department of the U.S. Army or Navy, or Department of Defense. Some of the authors are employees of the U.S. Government, and this work was prepared as part of their official duties. NR 32 TC 0 Z9 0 U1 3 U2 5 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD APR 25 PY 2016 VL 6 AR 24897 DI 10.1038/srep24897 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DK1EM UT WOS:000374655300001 PM 27109916 ER PT J AU Ananworanich, J Melvin, D Amador, JTR Childs, T Medin, G Boscolo, V Compagnucci, A Kanjanavanit, S Montero, S Gibb, DM AF Ananworanich, Jintanat Melvin, Diane Amador, Jose T. R. Childs, Tristan Medin, Gabriela Boscolo, Valentina Compagnucci, Alexandra Kanjanavanit, Suparat Montero, Samuel Gibb, Diana M. CA PENTA 11 Study Grp TI Neurocognition and quality of life after reinitiating antiretroviral therapy in children randomized to planned treatment interruption SO AIDS LA English DT Article DE antiretroviral therapy; neurodevelopment; treatment interruption; HIV; quality of life; neurocognition; children ID HIV-INFECTED CHILDREN; PERINATALLY ACQUIRED HIV; NEURODEVELOPMENTAL OUTCOMES; YOUNG-CHILDREN; ADOLESCENCE; CHILDHOOD; INFANTS; REMISSION; SEVERITY; PREDICT AB Objective: Understanding the effects of antiretroviral treatment (ART) interruption on neurocognition and quality of life (QoL) are important for managing unplanned interruptions and planned interruptions in HIV cure research. Design: Children previously randomized to continuous (continuous ART, n = 41) vs. planned treatment interruption (PTI, n = 47) in the Pediatric European Network for Treatment of AIDS (PENTA) 11 study were enrolled. At study end, PTI children resumed ART. At 1 and 2 years following study end, children were assessed by the coding, symbol search and digit span subtests of Wechsler Intelligence Scale for Children (6-16 years old) or Wechsler Adult Intelligence Scale (>= 17 years old) and by Pediatrics QoL questionnaires for physical and psychological QoL. Transformed scaled scores for neurocognition and mean standardized scores for QoL were compared between arms by t-test and Mann-Whitney U test, respectively. Scores indicating clinical concern were compared (<7 for neurocognition and <70 for QoL tests). Results: Characteristics were similar between arms with a median age of 12.6 years, CD4(+) of 830 cells/mu l and HIV RNA of 1.7 log(10)copies/ml. The median cumulative ART exposure was 9.6 in continuous ART vs. 7.7 years in PTI (P = 0.02). PTI children had a median of 12 months off ART and had resumed ART for 25.2 months at time of first assessment. Neurocognitive scores were similar between arms for all tests. Physical and psychological QoL scores were no different. About 40% had low neurocognitive and QoL scores indicating clinical concern. Conclusion: No differences in information processing speed, sustained attention, short-term memory and QoL functioning were observed between children previously randomized to continuous ART vs. PTI in the PENTA 11 trial. C1 [Ananworanich, Jintanat] Thai Red Cross AIDS Res Ctr, HIV Netherlands Australia Thailand Res Collaborat, Bangkok, Thailand. [Melvin, Diane] Imperial Coll Healthcare NHS Trust, London, England. [Amador, Jose T. R.; Medin, Gabriela] Hosp Clin San Carlos, Madrid, Spain. [Childs, Tristan; Montero, Samuel; Gibb, Diana M.] UCL, Inst Clin Trials & Methodol, MRC Clin Trials Unit, London, England. [Boscolo, Valentina] Univ Padua, Pediat Clin, Padua, Italy. [Compagnucci, Alexandra] Inserm ANRS, SC10 US19, Villejuif, France. [Kanjanavanit, Suparat] Nakornping Hosp, Chiang Mai, Thailand. RP Ananworanich, J (reprint author), Henry M Jackson Fdn Adv Mil Med, Walter Reed Army Inst Res, US Mil HIV Res Program, Bethesda, MD USA. EM jananworanich@hivresearch.org OI Nunez Cuadros, Esmeralda/0000-0003-1938-1678 FU European Commission/European Union [260694, LSHP-CT-2006018865, QLK2-CT-2000-00150]; PENTA Foundation FX Sources of support: PENTA is a coordinated action of the European Commission/European Union, supported by the seventh framework programme (FP7/2007-2013) under the Eurocoord grant agreement number 260694, the sixth framework contract number LSHP-CT-2006018865, the fifth framework programme contract number QLK2-CT-2000-00150, and by the PENTA Foundation. NR 31 TC 0 Z9 0 U1 3 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0269-9370 EI 1473-5571 J9 AIDS JI Aids PD APR 24 PY 2016 VL 30 IS 7 BP 1075 EP 1081 DI 10.1097/QAD.0000000000001011 PG 7 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA DI1BA UT WOS:000373229800002 PM 26730569 ER PT J AU Sliozberg, YR Kroger, M Chantawansri, TL AF Sliozberg, Yelena R. Kroger, Martin Chantawansri, Tanya L. TI Fast equilibration protocol for million atom systems of highly entangled linear polyethylene chains SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID MONTE-CARLO-SIMULATION; MOLECULAR-DYNAMICS SIMULATIONS; POLYMER MELTS; SEMICRYSTALLINE POLYETHYLENE; MECHANICAL-PROPERTIES; DEFORMATION; ALGORITHM; NANOFIBERS; LENGTH; MODEL AB Equilibrated systems of entangled polymer melts cannot be produced using direct brute force equilibration due to the slow reptation dynamics exhibited by high molecular weight chains. Instead, these dense systems are produced using computational techniques such as Monte Carlo-Molecular Dynamics hybrid algorithms, though the use of soft potentials has also shown promise mainly for coarse-grained polymeric systems. Through the use of soft-potentials, the melt can be equilibrated via molecular dynamics at intermediate and long length scales prior to switching to a Lennard-Jones potential. We will outline two different equilibration protocols, which use various degrees of information to produce the starting configurations. In one protocol, we use only the equilibrium bond angle, bond length, and target density during the construction of the simulation cell, where the information is obtained from available experimental data and extracted from the force field without performing any prior simulation. In the second protocol, we moreover utilize the equilibrium radial distribution function and dihedral angle distribution. This information can be obtained from experimental data or from a simulation of short unentangled chains. Both methods can be used to prepare equilibrated and highly entangled systems, but the second protocol is much more computationally efficient. These systems can be strictly monodisperse or optionally polydisperse depending on the starting chain distribution. Our protocols, which utilize a soft-core harmonic potential, will be applied for the first time to equilibrate a million particle system of polyethylene chains consisting of 1000 united atoms at various temperatures. Calculations of structural and entanglement properties demonstrate that this method can be used as an alternative towards the generation of entangled equilibrium structures. Published by AIP Publishing. C1 [Sliozberg, Yelena R.; Chantawansri, Tanya L.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Sliozberg, Yelena R.] TKC Global Inc, Aberdeen Proving Ground, MD 21005 USA. [Kroger, Martin] ETH, Dept Mat, Polymer Phys, Leopold Ruzicka Weg 4, CH-8093 Zurich, Switzerland. RP Sliozberg, YR (reprint author), US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA.; Sliozberg, YR (reprint author), TKC Global Inc, Aberdeen Proving Ground, MD 21005 USA. RI Kroger, Martin/C-1946-2008 OI Kroger, Martin/0000-0003-1402-6714 FU U.S. Army Research Laboratory [W911-QX-14-C0016]; Swiss National Science Foundation [SNF 200021_156106] FX The authors would like to thank Professors Jay Schieber, Mark Robbins, Mr. Thomas O'Connor, and Dr. Jan Andzelm and Dr. Robert Elder for useful discussion. Calculations were performed using the DOD Supercomputing Resource Center located at the Air Force and Navy Laboratories. The research reported in this document was performed in connection with Contract/Instrument No. W911-QX-14-C0016 with the U.S. Army Research Laboratory. The views and conclusions contained in this document are those of TKC Global, Inc. and the U.S. Army Research Laboratory. Citation of manufacturer's or trade names does not constitute an official endorsement or approval of the use thereof. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation hereon. M.K. would like to acknowledge support by the Swiss National Science Foundation through Grant No. SNF 200021_156106. NR 51 TC 3 Z9 3 U1 3 U2 10 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-9606 EI 1089-7690 J9 J CHEM PHYS JI J. Chem. Phys. PD APR 21 PY 2016 VL 144 IS 15 AR 154901 DI 10.1063/1.4946802 PG 12 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA DL6YM UT WOS:000375786000038 PM 27389234 ER PT J AU Duy, J Koehler, JW Honko, AN Schoepp, RJ Wauquier, N Gonzalez, JP Pitt, ML Mucker, EM Johnson, JC O'Hearn, A Bangura, J Coomber, M Minogue, TD AF Duy, Janice Koehler, Jeffrey W. Honko, Anna N. Schoepp, Randal J. Wauquier, Nadia Gonzalez, Jean-Paul Pitt, M. Louise Mucker, Eric M. Johnson, Joshua C. O'Hearn, Aileen Bangura, James Coomber, Moinya Minogue, Timothy D. TI Circulating microRNA profiles of Ebola virus infection SO SCIENTIFIC REPORTS LA English DT Article ID ZAIRE EBOLAVIRUS; SIERRA-LEONE; DISEASE; CLASSIFICATION; EXPRESSION; SUPPORT; CANCER; TIME; GLYCOPROTEIN; TRANSMISSION AB Early detection of Ebola virus (EBOV) infection is essential to halting transmission and adjudicating appropriate treatment. However, current methods rely on viral identification, and this approach can misdiagnose presymptomatic and asymptomatic individuals. In contrast, disease-driven alterations in the host transcriptome can be exploited for pathogen-specific diagnostic biomarkers. Here, we present for the first time EBOV-induced changes in circulating miRNA populations of nonhuman primates (NHPs) and humans. We retrospectively profiled longitudinally-collected plasma samples from rhesus macaques challenged via intramuscular and aerosol routes and found 36 miRNAs differentially present in both groups. Comparison of miRNA abundances to viral loads uncovered 15 highly correlated miRNAs common to EBOV-infected NHPs and humans. As proof of principle, we developed an eight-miRNA classifier that correctly categorized infection status in 64/74 (86%) human and NHP samples. The classifier identified acute infections in 27/29 (93.1%) samples and in 6/12 (50%) presymptomatic NHPs. These findings showed applicability of NHP-derived miRNAs to a human cohort, and with additional research the resulting classifiers could impact the current capability to diagnose presymptomatic and asymptomatic EBOV infections. C1 [Duy, Janice; Koehler, Jeffrey W.; Schoepp, Randal J.; O'Hearn, Aileen; Minogue, Timothy D.] US Army, Med Res Inst Infect Dis, Diagnost Syst Div, Frederick, MD USA. [Honko, Anna N.; Pitt, M. Louise; Mucker, Eric M.; Johnson, Joshua C.] US Army, Med Res Inst Infect Dis, Div Virol, Frederick, MD 21701 USA. [Wauquier, Nadia; Bangura, James; Coomber, Moinya] Metabiota, Kenema, Sierra Leone. [Gonzalez, Jean-Paul] Metabiota, Washington, DC USA. [Honko, Anna N.; Johnson, Joshua C.] NIAID, Integrated Res Facil, NIH, Frederick, MD USA. RP Minogue, TD (reprint author), US Army, Med Res Inst Infect Dis, Diagnost Syst Div, Frederick, MD USA. EM timothy.d.minogue.civ@mail.mil OI Honko, Anna/0000-0001-9165-148X; Koehler, Jeffrey/0000-0003-3225-6599 FU Defense Threat Reduction Agency award [CB3630] FX The authors would like to thank the members of the Virology Division, Pathology Division and the Center for Aerobiological Sciences at USAMRIID for study support. Specifically, we would like to thank the following for their assistance: Heather Esham, Joshua Shamblin, Ginger Donnelly, Nancy Twenhafel, Dave Dyer and Steve Orr. We would also like to thank Dr. Christopher Stefan for his assistance. Funding for this work was provided through Defense Threat Reduction Agency award #CB3630 ( awarded to Timothy D. Minogue and Jeffrey W. Koehler). The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication. NR 69 TC 2 Z9 2 U1 0 U2 4 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD APR 21 PY 2016 VL 6 AR 24496 DI 10.1038/srep24496 PG 13 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DJ8SR UT WOS:000374483800001 PM 27098369 ER PT J AU Kiziltas, A Nazari, B Kiziltas, EE Gardner, DJ Han, Y Rushing, TS AF Kiziltas, Alper Nazari, Behzad Kiziltas, Esra Erbas Gardner, Douglas J. Han, Yousoo Rushing, Todd S. TI Method to reinforce polylactic acid with cellulose nanofibers via a polyhydroxybutyrate carrier system SO CARBOHYDRATE POLYMERS LA English DT Article DE Cellulose nanofibers (CNF); Polylactic acid (PLA); Rheology; Polyhydroxybutyrate (PHB); Morphology ID NYLON 6 COMPOSITES; SURFACE-MODIFICATION; BIODEGRADABLE POLYMERS; MECHANICAL-PROPERTIES; PHYSICAL-PROPERTIES; PLA COMPOSITES; NANOCOMPOSITES; BLENDS; NANOWHISKERS; DISPERSION AB The elastic moduli of PLA reinforced with 5 and 10 wt.% CNF with the carrier, at a frequency (co) of 0.07, were 67% and 415% higher, respectively, than that of neat PLA. The shear viscosity at a shear rate of 0.01 (eta(0.01)) for PLA + 10 wt.% CNF was 32% higher than that of the neat PLA matrix. The eta(0.01) of PLA reinforced with 5 wt.% CNF and the PHB carrier was similar to neat PLA. The tensile and flexural moduli of elasticity of the nanocomposites continuously increased with increased CNF loading. The results of the mechanical property measurements are in accordance with the rheological data. The CNF appeared to be better dispersed (less-aggregated nanofibers) in the PLA reinforced with 5 wt.% CNF and the PHB carrier. Possible applications for the composites studied in this research are packaging materials, construction materials, and auto parts for interior applications. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Kiziltas, Alper; Gardner, Douglas J.; Han, Yousoo] Univ Maine, Adv Struct & Composites Ctr AEWC, Orono, ME 04469 USA. [Kiziltas, Alper] Univ Bartin, Fac Forestry, Dept Forest Ind Engn, TR-74100 Bartin, Turkey. [Nazari, Behzad] Univ Maine, Dept Chem Engn, Orono, ME 04469 USA. [Kiziltas, Esra Erbas] Sci & Technol Res Council Turkey TUBITAK, TR-06100 Ankara, Turkey. [Rushing, Todd S.] US Army Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. RP Kiziltas, A (reprint author), Univ Maine, Adv Struct & Composites Ctr AEWC, Orono, ME 04469 USA. EM kiziltasalper@gmail.com FU U.S. Army Engineer Research and Development Center project [912HZ-07-2-0013]; Maine Agricultural and Forest Experiment Station (MAFES) project [ME09615-08MS] FX Funding was provided by the U.S. Army Engineer Research and Development Center project 912HZ-07-2-0013 and the Maine Agricultural and Forest Experiment Station (MAFES) project ME09615-08MS. NR 51 TC 6 Z9 7 U1 18 U2 57 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0144-8617 EI 1879-1344 J9 CARBOHYD POLYM JI Carbohydr. Polym. PD APR 20 PY 2016 VL 140 BP 393 EP 399 DI 10.1016/j.carbpol.2015.12.059 PG 7 WC Chemistry, Applied; Chemistry, Organic; Polymer Science SC Chemistry; Polymer Science GA DD5JA UT WOS:000369958300047 PM 26876866 ER PT J AU Fasinu, PS Avula, B Tekwani, BL Nanayakkara, NPD Wang, YH Herath, HMTB McChesney, JD Reichard, GA Marcsisin, SR Elsohly, MA Khan, SI Khan, IA Walker, LA AF Fasinu, Pius S. Avula, Bharathi Tekwani, Babu L. Nanayakkara, N. P. Dhammika Wang, Yan-Hong Herath, H. M. T. Bandara McChesney, James D. Reichard, Gregory A. Marcsisin, Sean R. Elsohly, Mahmoud A. Khan, Shabana I. Khan, Ikhlas A. Walker, Larry A. TI Differential kinetic profiles and metabolism of primaquine enantiomers by human hepatocytes SO MALARIA JOURNAL LA English DT Article DE Enantioselectivity; Hepatocytes; Malaria; Metabolism; Primaquine enantiomers; Primaquine metabolites ID ANTIMALARIAL-DRUG PRIMAQUINE; HUMAN-ERYTHROCYTES; VIVAX MALARIA; IN-VITRO; CYP 2D6; PHARMACOKINETICS; IDENTIFICATION AB Background: The clinical utility of primaquine (PQ), used as a racemic mixture of two enantiomers, is limited due to metabolism-linked hemolytic toxicity in individuals with genetic deficiency in glucose-6-phosphate dehydrogenase. The current study investigated differential metabolism of PQ enantiomers in light of the suggestions that toxicity and efficacy might be largely enantioselective. Methods: Stable isotope C-13-labelled primaquine and its two enantiomers (+)-PQ, (-)-PQ were separately incubated with cryopreserved human hepatocytes. Time-tracked substrate depletion and metabolite production were monitored via UHPLC-MS/MS. Results: The initial half-life of 217 and 65 min; elimination rate constants (lambda) of 0.19 and 0.64 h(-1); intrinsic clearance (Cl-int) of 2.55 and 8.49 (mu L/min)/million cells, which when up-scaled yielded Cl-int of 6.49 and 21.6 (mL/min)/kg body mass was obtained respectively for (+)-and (-)-PQ. The extrapolation of in vitro intrinsic clearance to in vivo human hepatic blood clearance, performed using the well-stirred liver model, showed that the rate of hepatic clearance of (+)-PQ was only 45 % that of (-)-PQ. Two major primary routes of metabolism were observed-oxidative deamination of the terminal amine and hydroxylations on the quinoline moiety of PQ. The major deaminated metabolite, carboxyprimaquine (CPQ) was preferentially generated from the (-)-PQ. Other deaminated metabolites including PQ terminal alcohol (m/z 261), a cyclized side chain derivative from the aldehyde (m/z 241), cyclized carboxylic acid derivative (m/z 257), a quinone-imine product of hydroxylated CPQ (m/z 289), CPQ glucuronide (m/z 451) and the glucuronide of PQ alcohol (m/z 437) were all preferentially generated from the (-)-PQ. The major quinoline oxidation product (m/z 274) was preferentially generated from (+)-PQ. In addition to the products of the two metabolic pathways, two other major metabolites were observed: a prominent glycosylated conjugate of PQ on the terminal amine (m/z 422), peaking by 30 min and preferentially generated by (+)-PQ; and the carbamoyl glucuronide of PQ (m/z 480) exclusively generated from (+)-PQ. Conclusion: Metabolism of PQ showed enantioselectivity. These findings may provide important information in establishing clinical differences in PQ enantiomers. C1 [Fasinu, Pius S.; Avula, Bharathi; Tekwani, Babu L.; Nanayakkara, N. P. Dhammika; Wang, Yan-Hong; Herath, H. M. T. Bandara; Elsohly, Mahmoud A.; Khan, Shabana I.; Khan, Ikhlas A.; Walker, Larry A.] Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 USA. [Tekwani, Babu L.; Khan, Shabana I.; Khan, Ikhlas A.; Walker, Larry A.] Univ Mississippi, Sch Pharm, Dept BioMol Sci, University, MS 38677 USA. [Elsohly, Mahmoud A.] Univ Mississippi, Sch Pharm, Dept Pharmaceut Sci, University, MS 38677 USA. [Elsohly, Mahmoud A.] Univ Mississippi, Sch Pharm, Dept Drug Delivery, University, MS 38677 USA. [Elsohly, Mahmoud A.] ElSohly Labs Inc, 5 Ind Pk Dr, Oxford, MS 38655 USA. [McChesney, James D.] Ironstone Separat Inc, Oxford, MS 38627 USA. [Reichard, Gregory A.; Marcsisin, Sean R.] Walter Reed Army Inst Res, Mil Malaria Res Program, Expt Therapeut Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. RP Walker, LA (reprint author), Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 USA. EM lwalker@olemiss.edu FU Bill and Melinda Gates Foundation [OPP53288]; US Army Medical Research and Materiel Command [W81XWH-10-2-0059, W81XWH-13-2-0026] FX This study was supported by the Bill and Melinda Gates Foundation Phase I Grand Challenge Explorations Award (OPP53288) and the US Army Medical Research and Materiel Command Awards Nos. W81XWH-10-2-0059 and W81XWH-13-2-0026 to the University of Mississippi. The authors thank Dr. David Jollow, Medical University of South Carolina, for his continuing input and advice and help in data interpretations. NR 27 TC 1 Z9 1 U1 3 U2 7 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD APR 19 PY 2016 VL 15 AR 224 DI 10.1186/s12936-016-1270-1 PG 12 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA DJ9EZ UT WOS:000374518100001 PM 27093859 ER PT J AU Zeitlin, L Geisbert, JB Deer, DJ Fenton, KA Bohorov, O Bohorova, N Goodman, C Kim, D Hiatt, A Pauly, MH Velasco, J Whaley, KJ Altmann, F Gruber, C Steinkellner, H Honko, AN Kuehne, AI Aman, MJ Sahandi, S Enterlein, S Zhan, XG Enria, D Geisbert, TW AF Zeitlin, Larry Geisbert, Joan B. Deer, Daniel J. Fenton, Karla A. Bohorov, Ognian Bohorova, Natasha Goodman, Charles Kim, Do Hiatt, Andrew Pauly, Michael H. Velasco, Jesus Whaley, Kevin J. Altmann, Friedrich Gruber, Clemens Steinkellner, Herta Honko, Anna N. Kuehne, Ana I. Aman, M. Javad Sahandi, Sara Enterlein, Sven Zhan, Xiaoguo Enria, Delia Geisbert, Thomas W. TI Monoclonal antibody therapy for Junin virus infection SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE Junin; therapy; immunotherapy; hemorrhagic fever ID ARGENTINE HEMORRHAGIC-FEVER; GUINEA-PIGS; IMMUNE PLASMA; EFFICACY; DISEASE; IGG; ENCEPHALITIS; PATHOGENESIS; EXPRESSION; MODEL AB Countermeasures against potential biothreat agents remain important to US Homeland Security, and many of these pharmaceuticals could have dual use in the improvement of global public health. Junin virus, the causative agent of Argentine hemorrhagic fever (AHF), is an arenavirus identified as a category A high-priority agent. There are no Food and Drug Administration (FDA) approved drugs available for preventing or treating AHF, and the current treatment option is limited to administration of immune plasma. Whereas immune plasma demonstrates the feasibility of passive immunotherapy, it is limited in quantity, variable in quality, and poses safety risks such as transmission of transfusion-borne diseases. In an effort to develop a monoclonal antibody (mAb)-based alternative to plasma, three previously described neutralizing murine mAbs were expressed as mouse-human chimeric antibodies and evaluated in the guinea pig model of AHF. These mAbs provided 100% protection against lethal challenge when administered 2 d after infection (dpi), and one of them(J199) was capable of providing 100% protection when treatment was initiated 6 dpi and 92% protection when initiated 7 dpi. The efficacy of J199 is superior to that previously described for all other evaluated drugs, and its high potency suggests that mAbs like J199 offer an economical alternative to immune plasma and an effective dual use (bioterrorism/public health) therapeutic. C1 [Zeitlin, Larry; Bohorov, Ognian; Bohorova, Natasha; Goodman, Charles; Kim, Do; Hiatt, Andrew; Pauly, Michael H.; Velasco, Jesus; Whaley, Kevin J.] Mapp Biopharmaceut Inc, San Diego, CA 92121 USA. [Geisbert, Joan B.; Deer, Daniel J.; Fenton, Karla A.; Geisbert, Thomas W.] Univ Texas Med Branch, Galveston Natl Lab, Galveston, TX 77555 USA. [Geisbert, Joan B.; Deer, Daniel J.; Fenton, Karla A.; Geisbert, Thomas W.] Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA. [Altmann, Friedrich; Gruber, Clemens] Univ Nat Resources & Appl Life Sci, Dept Chem, A-1190 Vienna, Austria. [Steinkellner, Herta] Univ Nat Resources & Appl Life Sci, Dept Appl Genet & Cell Biol, A-1190 Vienna, Austria. [Honko, Anna N.; Kuehne, Ana I.] US Army Med Res Inst Infect Dis, Virol Div, Frederick, MD 21702 USA. [Aman, M. Javad; Sahandi, Sara; Enterlein, Sven; Zhan, Xiaoguo] Integrated BioTherapeut Inc, Gaithersburg, MD 20878 USA. [Enria, Delia] Inst Nacl Enfermedades Virales Humanas, Buenos Aires, DF, Argentina. [Honko, Anna N.] NIAID, Integrated Res Facil, Frederick, MD 21702 USA. RP Zeitlin, L (reprint author), Mapp Biopharmaceut Inc, San Diego, CA 92121 USA.; Geisbert, TW (reprint author), Univ Texas Med Branch, Galveston Natl Lab, Galveston, TX 77555 USA.; Geisbert, TW (reprint author), Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA. EM larry.zeitlin@mappbio.com; twgeisbe@UTMB.EDU RI Steinkellner, Herta/N-4267-2016; OI Steinkellner, Herta/0000-0003-4823-1505; Honko, Anna/0000-0001-9165-148X FU National Institute of Allergy and Infectious Disease [AI111391] FX We thank Drs. Yuri Gleba and Victor Klimyuk (Icon Genetics) for access to the magnICON expression technology and Natalie Dobias and the Research Histopathology Core at UTMB for optimization of the immunohistochemistry protocol. This publication was made possible by National Institute of Allergy and Infectious Disease Grant AI111391. NR 33 TC 3 Z9 4 U1 2 U2 6 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD APR 19 PY 2016 VL 113 IS 16 BP 4458 EP 4463 DI 10.1073/pnas.1600996113 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DJ7LV UT WOS:000374393800062 PM 27044104 ER PT J AU Perea, J Libbey, B AF Perea, James Libbey, Brad TI Development of a heterodyne speckle imager to measure 3 degrees of vibrational freedom SO OPTICS EXPRESS LA English DT Article ID VIBROMETRY AB A laboratory system has demonstrated the measurement of three degrees of vibrational freedom simultaneously through heterodyne speckle imaging. The random interference pattern generated by the illumination of a rough surface with coherent light can be exploited to extract information about the surface motion. The optical speckle pattern is heterodyne mixed with a coherent reference. The recorded optical data is then processed to extract three dimensions of surface motion. Axial velocity is measured by demodulating the received time-varying intensity of high amplitude pixels. Tilt, a gradient of surface displacement, is calculated by measuring speckle translation following extraction of the speckle pattern from the mixed signal. This paper discusses the laboratory sensor concept, signal processing, and experimental results compared with numeric simulations. (C) 2016 Optical Society of America C1 [Perea, James; Libbey, Brad] US Army, RDECOM CERDEC Night Vis & Elect Sensors Directora, Ft Belvoir, VA 22060 USA. RP Perea, J (reprint author), US Army, RDECOM CERDEC Night Vis & Elect Sensors Directora, Ft Belvoir, VA 22060 USA. EM info@nvl.army.mil NR 24 TC 0 Z9 0 U1 1 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD APR 18 PY 2016 VL 24 IS 8 BP 8253 EP 8265 DI 10.1364/OE.24.008253 PG 13 WC Optics SC Optics GA DJ7KM UT WOS:000374390300038 PM 27137264 ER PT J AU Burgess, E AF Burgess, Edwin TI Red Platoon: A True Story of American Valor SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin] US Army, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, E (reprint author), US Army, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD APR 15 PY 2016 VL 141 IS 7 BP 101 EP 101 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA DJ8BM UT WOS:000374437100179 ER PT J AU Lesho, EP AF Lesho, Emil P. TI How Next-Generation Sequencing Might Not Transform Infectious Disease Practice SO CLINICAL INFECTIOUS DISEASES LA English DT Letter C1 [Lesho, Emil P.] Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD USA. RP Lesho, EP (reprint author), WRAIR, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM carolinelesho@yahoo.com NR 1 TC 2 Z9 2 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD APR 15 PY 2016 VL 62 IS 8 BP 1052 EP U137 DI 10.1093/cid/ciw008 PG 2 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA DK7EU UT WOS:000375088500024 PM 26908790 ER PT J AU Audet, GN Dineen, SM Quinn, CM Leon, LR AF Audet, Gerald N. Dineen, Shauna M. Quinn, Carrie M. Leon, Lisa R. TI Altered hypothalamic inflammatory gene expression correlates with heat stroke severity in a conscious rodent model SO BRAIN RESEARCH LA English DT Article DE Heat stroke; Hypothalamus; Hyperthermia; Central nervous system; Cytokines ID TUMOR-NECROSIS-FACTOR; SYSTEMIC INFLAMMATION; BRAIN INJURY; HEATSTROKE; MICE; RECEPTORS; CYTOKINES; STRESS; HYPOTHERMIA; CHEMOKINES AB It has been suggested that heat-induced hypothalamic damage mediates core temperature (T-c) disturbances during heat stroke (HS) recovery; this is significant as hypothermia and/or fever have been linked to severity and overall pathological insult. However, to date there has been a lack of histological evidence in support of these claims. We hypothesized that local hypothalamic cytokines and/or chemokines, known regulators of T-c are mediating the elevation in T-c during HS recovery even in the absence of histological damage. In experiment 1, the hypothalamus of Fischer 344 rats was examined for 84 cytokine/chemokine genes (real-time PCR) at multiple time points (T-c,T-max, 1, 3, and 10 days) during mild HS recovery. In experiment 2, the hypothalamus of three different HS severities (MILD, moderate [MOD], and severe [SEV]) in rats were examined for the same genes as experiment 1 as well as six oxidative damage markers, at a single intermediate time point (1 day). Systemic cytokines were also analyzed in experiment 2 across the three severities. There were significant alterations in 25 cytokines/chemokines expression at T-c,T-max, but little or no changes in expression at longer time points in experiment 1. In experiment 2 there were significant changes in gene expression in SEV rats only, with MILD and MOD rats showing baseline expression at 1 day, despite an absence of systemic cytokine expression in any severity. There was also no change in any oxidative marker of damage at 1 day, regardless of severity. In conclusion, we show only limited changes during long term recovery from HS, but demonstrate differences in hypothalamic gene expression patterns that may be driving HS pathology and morbidity. These findings contribute to our overall understanding of HS pathology in the CNS, as well as providing avenues for future pharmacological intervention. Published by Elsevier B.V. C1 [Audet, Gerald N.; Dineen, Shauna M.; Quinn, Carrie M.; Leon, Lisa R.] US Army, Environm Med Res Inst, Thermal & Mt Med Div, Kansas St,Bldg 42, Natick, MA 01760 USA. RP Audet, GN (reprint author), US Army, Environm Med Res Inst, Thermal & Mt Med Div, Kansas St,Bldg 42, Natick, MA 01760 USA. EM Gerald.n.audet.ctr@mail.mil FU U.S. Department of Energy; USAMRMC FX This research was supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Medical Research Institute of Environmental Medicine administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USAMRMC NR 41 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0006-8993 EI 1872-6240 J9 BRAIN RES JI Brain Res. PD APR 15 PY 2016 VL 1637 BP 81 EP 90 DI 10.1016/j.brainres.2016.01.048 PG 10 WC Neurosciences SC Neurosciences & Neurology GA DK0NY UT WOS:000374610700008 PM 26876741 ER PT J AU Onal, H Woodford, P Tweddale, SA Westervelt, JD Chen, MY Dissanayake, STM Pitois, G AF Oenal, Hayri Woodford, Philip Tweddale, Scott A. Westervelt, James D. Chen, Mengye Dissanayake, Sahan T. M. Pitois, Gauthier TI A dynamic simulation/optimization model for scheduling restoration of degraded military training lands SO JOURNAL OF ENVIRONMENTAL MANAGEMENT LA English DT Article DE Military training; Land damages; Rehabilitation; Simulation; Optimization ID FORT RILEY; DISTURBANCE; IMPACTS AB Intensive use of military vehicles on Department of Defense training installations causes deterioration in ground surface quality. Degraded lands restrict the scheduled training activities and jeopardize personnel and equipment safety. We present a simulation-optimization approach and develop a discrete dynamic optimization model to determine an optimum land restoration for a given training schedule and availability of financial resources to minimize the adverse effects of training on military lands. The model considers weather forecasts, scheduled maneuver exercises, and unique qualities and importance of the maneuver areas. An application of this approach to Fort Riley, Kansas, shows that: i) starting with natural conditions, the total amount of training damages would increase almost linearly and exceed a quarter of the training area and 228 gullies would be formed (mostly in the intensive training areas) if no restoration is carried out over 10 years; ii) assuming an initial state that resembles the present conditions, sustaining the landscape requires an annual restoration budget of $957 thousand; iii) targeting a uniform distribution of maneuver damages would increase the total damages and adversely affect the overall landscape quality, therefore a selective restoration strategy may be preferred; and iv) a proactive restoration strategy would be optimal where land degradations are repaired before they turn into more severe damages that are more expensive to repair and may pose a higher training risk. The last finding can be used as a rule-of-thumb for land restoration efforts in other installations with similar characteristics. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Oenal, Hayri; Chen, Mengye; Dissanayake, Sahan T. M.; Pitois, Gauthier] Univ Illinois, Dept Agr & Consumer Econ, 1301 W Gregory Dr, Urbana, IL 61822 USA. [Woodford, Philip] Woodford & Woodford Inc, 2822 Tatarrax Dr, Manhattan, KS 66502 USA. [Tweddale, Scott A.; Westervelt, James D.] US Army, Corps Engineers, ERDC CERL, POB 9005, Champaign, IL 61822 USA. RP Onal, H (reprint author), Univ Illinois, Dept Agr & Consumer Econ, 1301 W Gregory Dr, Urbana, IL 61822 USA. EM h-onal@illinois.edu OI Onal, Hayri/0000-0002-0307-1731; Dissanayake, Sahan/0000-0002-4342-5979 FU US Army Engineer and Development Center; Construction Engineering Research Laboratory (CERL) [W9132T-10-2-0016]; USDA National Institute of Food and Agriculture, Hatch Project [ILLU 05-0361] FX This study is partially supported by the US Army Engineer and Development Center and Construction Engineering Research Laboratory (CERL Agreement W9132T-10-2-0016 and the USDA National Institute of Food and Agriculture, Hatch Project No. ILLU 05-0361. NR 21 TC 0 Z9 0 U1 3 U2 7 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0301-4797 EI 1095-8630 J9 J ENVIRON MANAGE JI J. Environ. Manage. PD APR 15 PY 2016 VL 171 BP 144 EP 157 DI 10.1016/j.jenvman.2016.02.005 PG 14 WC Environmental Sciences SC Environmental Sciences & Ecology GA DH3IO UT WOS:000372680900017 PM 26895721 ER PT J AU Wilson, DT Barnes, BC Wu, DT Sum, AK AF Wilson, Daniel T. Barnes, Brian C. Wu, David T. Sum, Amadeu K. TI Molecular dynamics simulations of the formation of ethane clathrate hydrates SO FLUID PHASE EQUILIBRIA LA English DT Article DE Molecular simulation; Hydrates; Ethane; Nucleation; Formation ID NUCLEATION AB This study details molecular dynamics simulations for the formation of ethane clathrate hydrates. Ethane hydrate nucleation shares with methane hydrate nucleation the formation of coordinated guest clusters in water, resulting in structures such as guest-saturated pentagonal and hexagonal faces. Ethane hydrate also forms structure I, which consists of two 5(12) and six 5(12)6(2) cages in its unit cell. Observations from the simulations reveal differences between methane and ethane in the nucleation process, including the types and occupancies of cages. While the formation of occupied 5(12) cages dominates methane hydrate nucleation, nucleation of ethane hydrates predominately exhibits the 4(1)5(10)6(2) cage as both the first and most common early cage type. These 4(1)5(10)6(2) cages do not occur in the crystal structure, and due to their oblong shape, restrict the orientation of the coordinated guest ethane molecule. The initial kinetically favored 4(1)5(10)6(2) cages are observed to undergo transformation into different cage types, such as the thermodynamically favored 5(12)6(2) cage. (C) 2015 Elsevier B.V. All rights reserved. C1 [Wilson, Daniel T.; Barnes, Brian C.; Sum, Amadeu K.] Colorado Sch Mines, Dept Chem & Biol Engn, 1500 Illinois St, Golden, CO 80401 USA. [Barnes, Brian C.] US Army, Res Lab, RDRL WML B, Energet Mat Sci Branch, Aberdeen Proving Ground, MD 21005 USA. [Wu, David T.] Colorado Sch Mines, Dept Chem, 1500 Illinois St, Golden, CO 80401 USA. RP Sum, AK (reprint author), Colorado Sch Mines, Dept Chem & Biol Engn, 1500 Illinois St, Golden, CO 80401 USA.; Wu, DT (reprint author), Colorado Sch Mines, Dept Chem, 1500 Illinois St, Golden, CO 80401 USA. EM dwu@mines.edu; asum@mines.edu RI Sum, Amadeu/B-1103-2009 OI Sum, Amadeu/0000-0003-1903-4537 FU U.S. National Science Foundation [CHE-1125235]; CSM Hydrate Consortium; BP; Champion Technologies; Chevron; ConocoPhillips; ENI; ExxonMobil; Halliburton; Instituto Mexicano del Petroleo; Multi-Chem; Nalco; Petrobras; Schlumberger; Shell; SPT Group; Statoil; Total; NSF; National Renewable Energy Laboratory FX We acknowledge Dr. Parag Adhanghale for the initial work on this project. This work was partially funded by the U.S. National Science Foundation (CHE-1125235) and the CSM Hydrate Consortium (current and past members: BP, Champion Technologies, Chevron, ConocoPhillips, ENI, ExxonMobil, Halliburton, Instituto Mexicano del Petroleo, Multi-Chem, Nalco, Petrobras, Schlumberger, Shell, SPT Group, Statoil, and Total). The simulations were performed on HPC facilities at the Golden Energy Computing Organization at the Colorado School of Mines using resources acquired with financial assistance from the NSF and the National Renewable Energy Laboratory. NR 16 TC 1 Z9 1 U1 4 U2 23 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-3812 EI 1879-0224 J9 FLUID PHASE EQUILIBR JI Fluid Phase Equilib. PD APR 15 PY 2016 VL 413 SI SI BP 229 EP 234 DI 10.1016/j.fluid.2015.12.001 PG 6 WC Thermodynamics; Chemistry, Physical; Engineering, Chemical SC Thermodynamics; Chemistry; Engineering GA DF7RA UT WOS:000371554100032 ER PT J AU Robinson, JA Varanasi, C Voevodin, AA Li, LJ Robinson, JT Lou, J AF Robinson, Joshua A. Varanasi, Chakrapani Voevodin, Andrey A. Li, Lain-Jong Robinson, Jeremy T. Lou, Jun TI TWO-DIMENSIONAL HETEROSTRUCTURE MATERIALS SO JOURNAL OF MATERIALS RESEARCH LA English DT Editorial Material C1 [Robinson, Joshua A.] Penn State Univ, University Pk, PA 16802 USA. [Varanasi, Chakrapani] US Army, Res Off, Washington, DC USA. [Voevodin, Andrey A.] US Air Force, Res Lab, Wright Patterson AFB, OH USA. [Li, Lain-Jong] King Abdullah Univ Sci & Technol, Thuwal, Saudi Arabia. [Robinson, Jeremy T.] Naval Res Lab, Washington, DC 20375 USA. [Lou, Jun] Rice Univ, Houston, TX 77251 USA. RP Robinson, JA (reprint author), Penn State Univ, University Pk, PA 16802 USA. RI Li, Lain-Jong/D-5244-2011 OI Li, Lain-Jong/0000-0002-4059-7783 NR 0 TC 0 Z9 0 U1 5 U2 17 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0884-2914 EI 2044-5326 J9 J MATER RES JI J. Mater. Res. PD APR 14 PY 2016 VL 31 IS 7 BP 823 EP 823 DI 10.1557/jmr.2016.108 PG 1 WC Materials Science, Multidisciplinary SC Materials Science GA DM2LN UT WOS:000376178400001 ER PT J AU Bleckmann, M Eichhorst, M Schuch, M Kreuzer, W Hammond, VH Spiller, C Meyer, LW Herzig, N AF Bleckmann, M. Eichhorst, M. Schuch, M. Kreuzer, W. Hammond, V. H. Spiller, C. Meyer, L. W. Herzig, N. TI The influence of selected ECAP-processing routes on the material properties of Magnesium Elektron 675 SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE Magnesium alloys; Equal channel angular pressing; Mechanical characterization; EBSD ID CHANNEL ANGULAR EXTRUSION; MECHANICAL-PROPERTIES; MG ALLOY; CRYSTALLOGRAPHIC TEXTURE; MICROSTRUCTURE; BEHAVIOR; ANISOTROPY; DUCTILITY; EVOLUTION; STRENGTH AB Due to the continued interest in reducing weight in both automobile and aerospace structures, interest has grown in magnesium based alloys as a possible materials solution. Despite this interest, these alloys have not been widely utilized due to their relatively poor mechanical properties in comparison to other material systems. However, recent research has clearly indicated that improved mechanical properties can be achieved in these alloys through the use of severe plastic deformation processing methods. In this report, we examine the influence of equal channel angular pressing on the mechanical response of Elektron 675, a Mg-Gd-Y alloy. Results indicate that an appreciable increase in total elongation and absorbed energy can be obtained depending on the selected processing route. However, these improvements in elongation are somewhat offset by a slight reduction in tensile strength. The observed mechanical response is explained through microstructural analysis as well as texture measurements. (C) 2016 Elsevier B.V. All rights reserved. C1 [Bleckmann, M.; Schuch, M.; Kreuzer, W.; Hammond, V. H.] Wehrwissensch Inst Werk & Betriebsstoffe WIWeB, Inst Weg 1, D-85435 Erding, Germany. [Eichhorst, M.; Spiller, C.; Meyer, L. W.; Herzig, N.] Nordmetall GmbH, Mat & Impact Engn, Hauptstr fte 16, D-09221 Adorf Erzgebirge, Germany. [Hammond, V. H.] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD USA. RP Bleckmann, M (reprint author), Wehrwissensch Inst Werk & Betriebsstoffe WIWeB, Inst Weg 1, D-85435 Erding, Germany. EM MatthiasBleckmann@bundeswehr.org FU Office of the Deputy Assistant Secretary for Defense Exports and Cooperation (DASA (DEC)) FX In addition, one of the authors (VHH) would like to acknowledge funding received from the Office of the Deputy Assistant Secretary for Defense Exports and Cooperation (DASA (DE&C)) that enabled his appointment to WIWeB as part of the U.S. Department of Defense Engineer and Scientist Exchange Program. NR 36 TC 1 Z9 1 U1 6 U2 14 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 EI 1873-4936 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD APR 13 PY 2016 VL 660 BP 108 EP 117 DI 10.1016/j.msea.2016.02.059 PG 10 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA DJ3BH UT WOS:000374079300015 ER PT J AU Mitchell, GA Wasylkiwskyj, W AF Mitchell, Gregory A. Wasylkiwskyj, Wasyl TI Theoretical anisotropic transverse resonance technique for the design of low-profile wideband antennas SO IET MICROWAVES ANTENNAS & PROPAGATION LA English DT Article AB The authors derive an anisotropic transverse resonance technique enabling the design of a low profile, wideband radiating rectangular cavity. They calculate a tapered geometry that preserves an effective half wavelength resonance within a cavity partially loaded with an anisotropic medium. This design results in an antenna profile of lambda(o)/24, with 1.4 octaves of bandwidth, and a realised gain of 3.3-7.2 dB from 210 to 505 MHz. Using an adaption of a coaxial line to waveguide transition, which utilises two flat rectangular probes as a two-port matching network, as well as an external 180 degrees hybrid coupler as a phase splitter, they achieve a voltage standing wave ratio of better than 2:1 across the whole band. C1 [Mitchell, Gregory A.] US Army Res Lab, RF & Elect Directorate, Adelphi, MD USA. [Mitchell, Gregory A.; Wasylkiwskyj, Wasyl] George Washington Univ, Dept Elect Engn, Washington, DC USA. RP Mitchell, GA (reprint author), US Army Res Lab, RF & Elect Directorate, Adelphi, MD USA.; Mitchell, GA (reprint author), George Washington Univ, Dept Elect Engn, Washington, DC USA. EM gregory.a.mitchell1.civ@mail.mil NR 11 TC 0 Z9 0 U1 4 U2 4 PU INST ENGINEERING TECHNOLOGY-IET PI HERTFORD PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD SG1 2AY, ENGLAND SN 1751-8725 EI 1751-8733 J9 IET MICROW ANTENNA P JI IET Microw. Antennas Propag. PD APR 13 PY 2016 VL 10 IS 5 BP 487 EP 493 DI 10.1049/iet-map.2015.0470 PG 7 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA DJ0IM UT WOS:000373885700003 ER PT J AU Wingard, LA Johnson, EC Sabatini, JJ AF Wingard, Leah A. Johnson, Eric C. Sabatini, Jesse J. TI Efficient method for the cycloaminomethylation of glycoluril SO TETRAHEDRON LETTERS LA English DT Article DE Synthesis; Cycloaminomethylation; Glycoluril AB The efficient method for the cycloaminomethylation of glycoluril to yield 2,6-ditert-butylhexahydro-1H,5H-2,3a,4a,6,7a,8a-hexaazacyclopenta[def]fluorene-4,8-dione is described. The material is synthesized employing water as the solvent, and is isolated by filtration. This is an improvement over the previous reported synthetic method, which relied on the use of samarium trichloride catalysis, as well as silica gel column chromatographic purification to obtain the target product. Published by Elsevier Ltd. C1 [Sabatini, Jesse J.] US Army Res Lab, Energet Technol Branch, Aberdeen Proving Ground, MD 21005 USA. [Wingard, Leah A.] Oak Ridge Associated Univ, Belcamp, MD 21017 USA. [Johnson, Eric C.] TKC Global, 13873 Pk Ctr Rd, Herndon, VA 20171 USA. RP Sabatini, JJ (reprint author), US Army Res Lab, Energet Technol Branch, Aberdeen Proving Ground, MD 21005 USA. EM jesse.j.sabatini.civ@mail.mil FU Army Research Laboratory [W911NF-12-2-0019] FX Research was sponsored by the Army Research Laboratory was accomplished in part under Cooperative Agreement Number W911NF-12-2-0019. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 11 TC 2 Z9 2 U1 0 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0040-4039 J9 TETRAHEDRON LETT JI Tetrahedron Lett. PD APR 13 PY 2016 VL 57 IS 15 BP 1681 EP 1682 DI 10.1016/j.tetlet.2016.03.013 PG 2 WC Chemistry, Organic SC Chemistry GA DI5QB UT WOS:000373552600011 ER PT J AU Gonwong, S Chuenchitra, T Khantapura, P Islam, D Mason, CJ AF Gonwong, Siriphan Chuenchitra, Thippawan Khantapura, Patchariya Islam, Dilara Mason, Carl J. TI Measles susceptibility in young Thai men suggests need for young adult measles vaccination: a cross sectional study SO BMC PUBLIC HEALTH LA English DT Article DE Measles; Seroprevalence; Thailand; Young adult; Disease susceptibility; Vaccination ID ANTIBODY; SEROPREVALENCE; PREVALENCE AB Background: Measles remains a major public health concern in Thailand despite the introduction of vaccination since 1984. Similar to other countries, Thailand has experienced numerous measles outbreaks including adult communities such as university student dormitories, prisons, refugee camps, and military recruit camps. These outbreaks raise questions on the seroprotective antibody level in Thai adults. Methods: To better understand measles susceptibility in young Thai adults, a retrospective measles seroprevalence study on repository serum specimens obtained with informed consent from young Thai men entering the Royal Thai Army (RTA) during 2007-2008 was conducted. A total of 7760 stratified randomized samples were chosen by residence province. Measles IgG titer was measured using a commercial IgG quantitative ELISA kit following the manufacturer's instructions. An antibody level >= 250 International Units per Liter (IU/L) was interpreted as seropositive. Results: The overall measles seroprevalence was 78.5 % (95 % Confidence Interval: 77.6-79.4 %) with geometric mean titer of 738 IU/L (95 % Confidence Interval: 716-760 IU/L). The measles seroprevalence by province ranged from 59.6 % to 93.1 %. A trend of decreasing seroprevalence in the younger cohorts despite increasing immunization coverage was found. Lower seroprevalence than vaccination coverage was observed in the youngest age group. Conclusions: To achieve long term measles control and elimination, an integrated two doses vaccination strategy has been implemented in children in Thailand. This nationwide measles seroprevalence study in young adult RTA recruits found a measles seroprevalence lower than WHO's recommendation for measles outbreak prevention and elimination. These results raise concerns for measles control in Thailand. Supplementary immunization in young adults is essential especially in high-risk and densely populated communities to establish herd immunity for outbreak prevention and elimination. C1 [Gonwong, Siriphan; Khantapura, Patchariya; Islam, Dilara; Mason, Carl J.] Armed Forces Res Inst Med Sci, Dept Enter Dis, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. [Chuenchitra, Thippawan] Armed Forces Res Inst Med Sci, Div Res, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. RP Gonwong, S (reprint author), Armed Forces Res Inst Med Sci, Dept Enter Dis, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. EM siriphang@afrims.org OI MASON, CARL/0000-0002-3676-2811 FU Armed Forces Health Surveillance Center-Global Emerging Infections Surveillance and Response System FX This work was supported by the Armed Forces Health Surveillance Center-Global Emerging Infections Surveillance and Response System. NR 24 TC 1 Z9 1 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2458 J9 BMC PUBLIC HEALTH JI BMC Public Health PD APR 11 PY 2016 VL 16 AR 309 DI 10.1186/s12889-016-2987-z PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA DI7WB UT WOS:000373711600007 PM 27067256 ER PT J AU Huber, BR Meabon, JS Hoffer, ZS Zhang, J Hoekstra, JG Pagulayan, KF McMillan, PJ Mayer, CL Banks, WA Kraemer, BC Raskind, MA McGavern, DB Peskind, ER Cook, DG AF Huber, B. R. Meabon, J. S. Hoffer, Z. S. Zhang, J. Hoekstra, J. G. Pagulayan, K. F. McMillan, P. J. Mayer, C. L. Banks, W. A. Kraemer, B. C. Raskind, M. A. McGavern, D. B. Peskind, E. R. Cook, D. G. TI BLAST EXPOSURE CAUSES DYNAMIC MICROGLIAL/MACROPHAGE RESPONSES AND MICRODOMAINS OF BRAIN MICROVESSEL DYSFUNCTION SO NEUROSCIENCE LA English DT Article DE blood-brain barrier; two-photon microscopy; neuropathology; microglia; macrophages ID CHRONIC TRAUMATIC ENCEPHALOPATHY; IN-VIVO; MICROGLIAL ACTIVATION; WHITE-MATTER; MOUSE MODEL; INJURY; BLOOD; BARRIER; CORTEX; IMPACT AB Exposure to blast overpressure (BOP) is associated with behavioral, cognitive, and neuroimaging abnormalities. We investigated the dynamic responses of cortical vasculature and its relation to microglia/macrophage activation in mice using intravital two-photon microscopy following mild blast exposure. We found that blast caused vascular dysfunction evidenced by microdomains of aberrant vascular permeability. Microglial/macrophage activation was specifically associated with these restricted microdomains, as evidenced by rapid microglial process retraction, increased ameboid morphology, and escape of blood-borne Q-dot tracers that were internalized in microglial/macrophage cell bodies and phagosome-like compartments. Microdomains of cortical vascular disruption and microglial/macrophage activation were also associated with aberrant tight junction morphology that was more prominent after repetitive (3 x) blast exposure. Repetitive, but not single, BOPs also caused TNF alpha elevation two weeks post-blast. In addition, following a single BOP we found that aberrantly phosphorylated tau rapidly accumulated in perivascular domains, but cleared within four hours, suggesting it was removed from the perivascular area, degraded, and/or dephosphorylated. Taken together these findings argue that mild blast exposure causes an evolving CNS insult that is initiated by discrete disturbances of vascular function, thereby setting the stage for more protracted and more widespread neuro-inflammatory responses. Published by Elsevier Ltd. on behalf of IBRO. C1 [Huber, B. R.] Boston Univ, VA Jamaica Plain, Dept Neurol, Sch Med, Jamaica Plain, MA USA. [Meabon, J. S.; Pagulayan, K. F.; McMillan, P. J.; Mayer, C. L.; Raskind, M. A.; Peskind, E. R.] VA Puget Sound Healthcare Syst, Northwest Network Mental Illness Res Educ & Clin, Seattle, WA USA. [Meabon, J. S.; Pagulayan, K. F.; McMillan, P. J.; Mayer, C. L.; Raskind, M. A.; Peskind, E. R.] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98108 USA. [Hoffer, Z. S.] US Army, Madigan Army Med Ctr, Joint Base Lewis Mcchord, WA USA. [Zhang, J.; Hoekstra, J. G.] Univ Washington, Sch Med, Dept Pathol, Seattle, WA 98108 USA. [Banks, W. A.; Kraemer, B. C.; Cook, D. G.] Vet Affairs Puget Sound Hlth Care Syst, GRECC, Seattle, WA USA. [Banks, W. A.; Kraemer, B. C.; Cook, D. G.] Univ Washington, Dept Med, Div Gerontol & Geriatr Med, Seattle, WA 98108 USA. [McGavern, D. B.] NINDS, NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA. [Cook, D. G.] Univ Washington, Sch Med, Dept Pharmacol, Seattle, WA 98108 USA. RP Cook, DG (reprint author), Univ Washington, VA Puget Sound Hlth Care Syst, Dept Med, 1660 South Columbian Way, Seattle, WA 98108 USA. EM dgcook@u.washington.edu OI Hoekstra, Jake/0000-0001-6597-5878 FU Department of Veterans Affairs Office of Research and Development Medical Research Service; VA Rehabilitation Research and Development Service; University of Washington Royalty Research Fund [R01AG046619]; Northwest Network Mental Illness Research, Education and Clinical Center; Office of Academic Affiliations, Advanced Fellowship Program in Mental Illness Research and Treatment, Department of Veterans Affairs; NIH [T32 AG000258]; VA CSR&D Career Development Award [IK2 CX00516] FX This work was supported by the Department of Veterans Affairs Office of Research and Development Medical Research Service (D.G.C., B.C.K.), VA Rehabilitation Research and Development Service (E.R.P.), University of Washington Royalty Research Fund (D.G.C.); R01AG046619 (W.A.B.); Northwest Network Mental Illness Research, Education and Clinical Center (E.R.P., B.R.H., J.S.M., K.F.P., P.J.M., C.L.M.), Office of Academic Affiliations, Advanced Fellowship Program in Mental Illness Research and Treatment, Department of Veterans Affairs (B.R.H.); NIH T32 AG000258 (J.S.M.), VA CSR&D Career Development Award Program #IK2 CX00516 (K.F.P.). We thank Dr. Gerard Schellenberg (Univ. Pennsylvania) for providing Tau knock-out samples. NR 41 TC 1 Z9 1 U1 2 U2 15 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0306-4522 EI 1873-7544 J9 NEUROSCIENCE JI Neuroscience PD APR 5 PY 2016 VL 319 BP 206 EP 220 DI 10.1016/j.neuroscience.2016.01.022 PG 15 WC Neurosciences SC Neurosciences & Neurology GA DD9RD UT WOS:000370262400019 PM 26777891 ER PT J AU Singamaneni, SR Punugupati, S Prater, JT Narayan, J AF Singamaneni, Srinivasa Rao Punugupati, Sandhyarani Prater, John T. Narayan, Jagdish TI Diamagnetism to ferromagnetism in Sr-substituted epitaxial BaTiO3 thin films SO APPLIED PHYSICS LETTERS LA English DT Article ID LAALO3/SRTIO3 INTERFACE; SUPERCONDUCTIVITY; COEXISTENCE; DEPOSITION; GROWTH; LAYER AB We report on the ferromagnetic-like behavior in otherwise diamagnetic BaTiO3 (BTO) thin films upon doping with non-magnetic element Sr having the composition Ba0.4Sr0.6TiO3 (BST). The epitaxial integration of BST (similar to 800 nm) thick films on Si (100) substrate was achieved using MgO (40 nm) and TiN (20 nm) as buffer layers to prepare BST/MgO/TiN/Si (100) heterostructure by pulsed laser deposition. The c-axis oriented and cube-on-cube epitaxial BST is formed on Si (100) as evidenced by the in-plane and out-of-plane X-ray diffraction. All the deposited films are relaxed through domain matching epitaxy paradigm as observed from X-ray diffraction pattern and A(1)TO(3) mode (at 521.27 cm(-1)) of Raman spectra. As-deposited BST thin films reveal ferromagnetic-like properties, which persist up to 400 K. The magnetization decreases two-fold upon oxygen annealing. In contrast, as-deposited un-doped BTO films show diamagnetism. Electron spin resonance measurements reveal no evidence of external magnetic impurities. XRD and X-ray photoelectron spectroscopy spectra show significant changes influenced by Sr doping in BTO. The ferromagnetic-like behavior in BST could be due to the trapped electron donors from oxygen vacancies resulting from Sr-doping. (C) 2016 AIP Publishing LLC. C1 [Singamaneni, Srinivasa Rao; Prater, John T.] US Army, Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA. [Singamaneni, Srinivasa Rao; Punugupati, Sandhyarani; Prater, John T.; Narayan, Jagdish] N Carolina State Univ, Dept Mat Sci & Engn, Box 7907, Raleigh, NC 27695 USA. RP Singamaneni, SR (reprint author), US Army, Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA.; Singamaneni, SR (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Box 7907, Raleigh, NC 27695 USA. EM ssingam@ncsu.edu FU National Academy of Science (NAS), USA; Army Research Office [W911NF-04-D-0003]; State of North Carolina; National Science Foundation FX S.R.S. acknowledges National Academy of Science (NAS), USA, for awarding the NRC postdoctoral research associate fellowship. The authors are pleased to acknowledge the support of the Army Research Office under Grant No. W911NF-04-D-0003. We thank Dr. L. Cao and Dr. Alex Smirnov for their help in Raman and ESR measurements, respectively. Also, the authors acknowledge the use of the Analytical Instrumentation Facility (AIF) at North Carolina State University, which is supported by the State of North Carolina and the National Science Foundation. NR 37 TC 2 Z9 2 U1 19 U2 36 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD APR 4 PY 2016 VL 108 IS 14 AR 142407 DI 10.1063/1.4945683 PG 5 WC Physics, Applied SC Physics GA DJ5EX UT WOS:000374230700032 ER PT J AU Shen, TC Drost, RJ Sadler, BM Rzasa, JR Davis, CC AF Shen, Thomas C. Drost, Robert J. Sadler, Brian M. Rzasa, John R. Davis, Christopher C. TI Omnidirectional beacon-localization using a catadioptric system SO OPTICS EXPRESS LA English DT Article ID VISIBLE-LIGHT COMMUNICATION; OPTICAL COMMUNICATION; OBSTACLE DETECTION; TRACKING; NAVIGATION; ERROR; ROBOT; LINK; ACQUISITION; VARIABLES AB We present a catadioptric beacon localization system that can provide mobile network nodes with omnidirectional situational awareness of neighboring nodes. In this system, a receiver composed of a hyperboloidal mirror and camera is used to estimate the azimuth, elevation, and range of an LED beacon. We provide a general framework for understanding the propagation of error in the angle-of-arrival estimation and then present an experimental realization of such a system. The situational awareness provided by the proposed system can enable the alignment of communication nodes in an optical wireless network, which may be particularly useful in addressing RF-denied environments. (C) 2016 Optical Society of America C1 [Shen, Thomas C.; Rzasa, John R.; Davis, Christopher C.] Univ Maryland, Elect & Comp Engn Dept, College Pk, MD 20742 USA. [Drost, Robert J.; Sadler, Brian M.] US Army Res Lab, Adelphi, MD 20783 USA. RP Shen, TC (reprint author), Univ Maryland, Elect & Comp Engn Dept, College Pk, MD 20742 USA. EM tshen@umd.edu FU U.S. Army Research Office (ARO) [W911NF-13-1-0003] FX Research at the University of Maryland was supported by U.S. Army Research Office (ARO) under grant number W911NF-13-1-0003. NR 45 TC 1 Z9 1 U1 0 U2 9 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD APR 4 PY 2016 VL 24 IS 7 BP 6931 EP 6944 DI 10.1364/OE.24.006931 PG 14 WC Optics SC Optics GA DI4KP UT WOS:000373469100011 PM 27136988 ER PT J AU Kim, Y Wellum, G Mello, K Strawhecker, KE Thoms, R Giaya, A Wyslouzil, BE AF Kim, Yoojeong Wellum, Glyn Mello, Kerrianne Strawhecker, Kenneth E. Thoms, Richard Giaya, Arjan Wyslouzil, Barbara E. TI Effects of relative humidity and particle and surface properties on particle resuspension rates SO AEROSOL SCIENCE AND TECHNOLOGY LA English DT Article DE Nicole Riemer ID WIND-TUNNEL EXPERIMENTS; ATOMIC-FORCE MICROSCOPE; TURBULENT AIR-FLOW; INDOOR SURFACES; MICROPARTICLE DETACHMENT; CAPILLARY CONDENSATION; ADHESION FORCES; HIGH-RESOLUTION; DEPOSITION; MODELS AB Wind tunnel experiments examined the coupled effects of relative humidity (RH) and surface and particle properties on aerodynamically induced resuspension. Hydrophilic glass spheres and hydrophobic polyethylene spheres similar to 20 mu m in diameter, with nanoscale surface features, were resuspended from hydrophilic glass, hydrophobic chemical agent resistant coating (CARC), and gold surfaces. Roughness of the glass and gold surfaces was on the nanoscale, whereas CARC surfaces had microscale roughness. Different particle-surface combinations yielded van der Waals interactions that varied by a factor of 4, but these differences had a relatively minor effect on resuspension. Wind tunnel RH was varied between 7% and 78%. Overall, RH affected the resuspension of hydrophilic particles on hydrophilic surfaces most strongly and that of hydrophobic particles on hydrophobic surfaces the least. For each particle-surface combination there was a threshold RH value below which resuspension rates were essentially constant and in good agreement with a dimensionless model of particle resuspension. Copyright (c) 2016 American Association for Aerosol Research C1 [Kim, Yoojeong; Wellum, Glyn; Mello, Kerrianne; Giaya, Arjan] Triton Syst Inc, 200 Turnpike Rd, Chelmsford, MA 01824 USA. [Strawhecker, Kenneth E.] Army Res Lab, Aberdeen Proving Ground, MD USA. [Thoms, Richard] CFD Res Corp, Huntsville, AL USA. [Wyslouzil, Barbara E.] Ohio State Univ, William G Lowrie Dept Chem & Biomol Engn, Columbus, OH 43210 USA. [Wyslouzil, Barbara E.] Ohio State Univ, Dept Chem & Biochem, Columbus, OH 43210 USA. RP Kim, Y (reprint author), Triton Syst Inc, 200 Turnpike Rd, Chelmsford, MA 01824 USA. EM ykim@tritonsys.com OI Wyslouzil, Barbara/0000-0001-9763-5990 FU Defense Threat Reduction Agency [HDTRA1-10-C-0069] FX Support for this work was provided by the Defense Threat Reduction Agency under contract HDTRA1-10-C-0069. The views expressed herein are those of the authors and not necessarily those of the Department of Defense, the Defense Threat Reduction Agency, or any other agency or component of the US Government. NR 62 TC 1 Z9 1 U1 5 U2 17 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 0278-6826 EI 1521-7388 J9 AEROSOL SCI TECH JI Aerosol Sci. Technol. PD APR 2 PY 2016 VL 50 IS 4 BP 339 EP 352 DI 10.1080/02786826.2016.1152350 PG 14 WC Engineering, Chemical; Engineering, Mechanical; Environmental Sciences; Meteorology & Atmospheric Sciences SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA DI1VV UT WOS:000373285600004 ER PT J AU Campbell, DJ Campbell, KM AF Campbell, Donald J. Campbell, Kathleen M. TI Police/military convergence in the USA as organisational mimicry SO POLICING & SOCIETY LA English DT Article DE police/military convergence; organisational mimicry ID GARRISON STATE; UNITED-STATES; POLICE; MILITARY; SOLDIERS; ATTITUDES; AMERICA; ARMY; AGE AB This paper examines the developing convergence between the police and the military, two institutions American society has traditionally separated to safeguard civil liberty. The analysis results in three main conclusions. First, when viewed in a broader sociopolitical context, the current convergence is less singular than it appears, with such overlaps occurring periodically in the past. Second, organisational mimicry offers a conceptual framework for understanding the current convergence. Third, the convergence remains a significant political development, requiring further organisational and social assessment. The paper concludes with a brief discussion of a potential alternative to the convergence. C1 [Campbell, Donald J.; Campbell, Kathleen M.] US Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA. RP Campbell, DJ (reprint author), US Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA. EM LD6829@usma.edu NR 65 TC 0 Z9 0 U1 2 U2 8 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 1043-9463 EI 1477-2728 J9 POLIC SOC JI Polic. Soc. PD APR 2 PY 2016 VL 26 IS 3 BP 332 EP 353 DI 10.1080/10439463.2014.942852 PG 22 WC Criminology & Penology SC Criminology & Penology GA DI0QI UT WOS:000373201600005 ER PT J AU Njamkepo, E Fawal, N Tran-Dien, A Hawkey, J Strockbine, N Jenkins, C Talukder, KA Bercion, R Kuleshov, K Kolinska, R Russell, JE Kaftyreva, L Accou-Demartin, M Karas, A Vandenberg, O Mather, AE Mason, CJ Page, AJ Ramamurthy, T Bizet, C Gamian, A Carle, I Sow, AG Bouchier, C Wester, AL Lejay-Collin, M Fonkoua, MC Le Hello, S Blaser, MJ Jernberg, C Ruckly, C Merens, A Page, AL Aslett, M Roggentin, P Fruth, A Denamur, E Venkatesan, M Bercovier, H Bodhidatta, L Chiou, CS Clermont, D Colonna, B Egorova, S Pazhani, GP Ezernitchi, AV Guigon, G Harris, SR Izumiya, H Korzeniowska-Kowal, A Lutynska, A Gouali, M Grimont, F Langendorf, C Marejkova, M Peterson, LAM Perez-Perez, G Ngandjio, A Podkolzin, A Souche, E Makarova, M Shipulin, GA Ye, CY Zemlickova, H Herpay, M Grimont, PAD Parkhill, J Sansonetti, P Holt, KE Brisse, S Thomson, NR Weill, FX AF Njamkepo, Elisabeth Fawal, Nizar Tran-Dien, Alicia Hawkey, Jane Strockbine, Nancy Jenkins, Claire Talukder, Kaisar A. Bercion, Raymond Kuleshov, Konstantin Kolinska, Renata Russell, Julie E. Kaftyreva, Lidia Accou-Demartin, Marie Karas, Andreas Vandenberg, Olivier Mather, Alison E. Mason, Carl J. Page, Andrew J. Ramamurthy, Thandavarayan Bizet, Chantal Gamian, Andrzej Carle, Isabelle Sow, Amy Gassama Bouchier, Christiane Wester, Astrid Louise Lejay-Collin, Monique Fonkoua, Marie-Christine Le Hello, Simon Blaser, Martin J. Jernberg, Cecilia Ruckly, Corinne Merens, Audrey Page, Anne-Laure Aslett, Martin Roggentin, Peter Fruth, Angelika Denamur, Erick Venkatesan, Malabi Bercovier, Herve Bodhidatta, Ladaporn Chiou, Chien-Shun Clermont, Dominique Colonna, Bianca Egorova, Svetlana Pazhani, Gururaja P. Ezernitchi, Analia V. Guigon, Ghislaine Harris, Simon R. Izumiya, Hidemasa Korzeniowska-Kowal, Agnieszka Lutynska, Anna Gouali, Malika Grimont, Francine Langendorf, Celine Marejkova, Monika Peterson, Lorea A. M. Perez-Perez, Guillermo Ngandjio, Antoinette Podkolzin, Alexander Souche, Erika Makarova, Mariia Shipulin, German A. Ye, Changyun Zemlickova, Helena Herpay, Mria Grimont, Patrick A. D. Parkhill, Julian Sansonetti, Philippe Holt, Kathryn E. Brisse, Sylvain Thomson, Nicholas R. Weill, Francois-Xavier TI Global phylogeography and evolutionary history of Shigella dysenteriae type 1 SO NATURE MICROBIOLOGY LA English DT Article ID ESCHERICHIA-COLI; MOLECULAR EPIDEMIOLOGY; PHYLOGENETIC ANALYSIS; PATHOGENICITY ISLAND; INTERACTIVE TREE; RESISTANCE GENES; PLASMIDS; SALMONELLA; ANNOTATION; SEQUENCES AB Together with plague, smallpox and typhus, epidemics of dysentery have been a major scourge of human populations for centuries(1). A previous genomic study concluded that Shigella dysenteriae type 1 (Sd1), the epidemic dysentery bacillus, emerged and spread worldwide after the First World War, with no clear pattern of transmission(2). This is not consistent with the massive cyclic dysentery epidemics reported in Europe during the eighteenth and nineteenth centuries(1,3,4) and the first isolation of Sd1 in Japan in 1897(5). Here, we report a whole-genome analysis of 331 Sd1 isolates from around the world, collected between 1915 and 2011, providing us with unprecedented insight into the historical spread of this pathogen. We show here that Sd1 has existed since at least the eighteenth century and that it swept the globe at the end of the nineteenth century, diversifying into distinct lineages associated with the First World War, Second World War and various conflicts or natural disasters across Africa, Asia and Central America. We also provide a unique historical perspective on the evolution of antibiotic resistance over a 100-year period, beginning decades before the antibiotic era, and identify a prevalent multiple antibiotic-resistant lineage in South Asia that was transmitted in several waves to Africa, where it caused severe outbreaks of disease. C1 [Njamkepo, Elisabeth; Fawal, Nizar; Tran-Dien, Alicia; Accou-Demartin, Marie; Carle, Isabelle; Lejay-Collin, Monique; Le Hello, Simon; Ruckly, Corinne; Gouali, Malika; Grimont, Francine; Grimont, Patrick A. D.; Weill, Francois-Xavier] Inst Pasteur, Unite Bacteries Pathogenes Enter, F-75724 Paris 15, France. [Hawkey, Jane; Holt, Kathryn E.] Univ Melbourne, Ctr Syst Genom, Parkville, Vic 3010, Australia. [Hawkey, Jane; Holt, Kathryn E.] Univ Melbourne, Mol Sci & Biotechnol Inst Bio21, Dept Biochem & Mol Biol, Parkville, Vic 3010, Australia. [Hawkey, Jane] Univ Melbourne, Sch Agr & Vet Sci, Parkville, Vic 3010, Australia. [Strockbine, Nancy] Ctr Dis Control & Prevent, Escherichia & Shigella Reference Unit, Atlanta, GA 30333 USA. [Jenkins, Claire] Publ Hlth England, Gastrointestinal Bacteria Reference Unit, Colindale NW9 5HT, England. [Talukder, Kaisar A.] Icddr B, Enter & Food Microbiol Lab, Dhaka 1212, Bangladesh. [Bercion, Raymond] Inst Pasteur, BP 923, Bangui, Cent Afr Republ. [Bercion, Raymond; Sow, Amy Gassama] Inst Pasteur, BP 220, Dakar, Senegal. [Kuleshov, Konstantin; Podkolzin, Alexander; Shipulin, German A.] Cent Res Inst Epidemiol, Fed Budget Inst Sci, Moscow 111123, Russia. [Kolinska, Renata; Zemlickova, Helena] Natl Inst Publ Hlth, CNCTC, Prague 10, Czech Republic. [Russell, Julie E.] Publ Hlth England, Natl Collect Type Cultures, Porton Down SP4 0JG, England. [Kaftyreva, Lidia; Egorova, Svetlana; Makarova, Mariia] Pasteur Inst St Petersburg, St Petersburg 197101, Russia. [Karas, Andreas] Univ KwaZulu Natal, Dept Med Microbiol, ZA-4041 Durban, South Africa. [Vandenberg, Olivier] Brussels Univ Hosp Lab, Dept Microbiol, LHUB ULB, B-1000 Brussels, Belgium. [Vandenberg, Olivier] Univ Libre Bruxelles, Sch Publ Hlth, Environm Hlth Res Ctr, B-1070 Brussels, Belgium. [Mather, Alison E.; Page, Andrew J.; Aslett, Martin; Harris, Simon R.; Parkhill, Julian; Thomson, Nicholas R.; Weill, Francois-Xavier] Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England. [Mather, Alison E.] Univ Cambridge, Dept Vet Med, Cambridge CB3 0ES, England. [Mason, Carl J.; Bodhidatta, Ladaporn] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Ramamurthy, Thandavarayan; Pazhani, Gururaja P.] NICED, Kolkata 700010, West Bengal, India. [Bizet, Chantal; Clermont, Dominique] Inst Pasteur, CIP, F-75724 Paris 15, France. [Gamian, Andrzej; Korzeniowska-Kowal, Agnieszka] Inst Immunol & Expt Therapy, Polish Collect Microorganisms, PL-53114 Wroclaw, Poland. [Bouchier, Christiane] Inst Pasteur, Plate Forme Genom PF1, F-75724 Paris 15, France. [Wester, Astrid Louise] Norwegian Inst Publ Hlth, Dept Foodborne Infect, N-0403 Oslo, Norway. [Fonkoua, Marie-Christine; Ngandjio, Antoinette] Ctr Pasteur Cameroun, BP 1274, Yaounde, Cameroon. [Blaser, Martin J.; Perez-Perez, Guillermo] NYU, Langone Med Ctr, Dept Med, New York, NY 10016 USA. [Blaser, Martin J.; Perez-Perez, Guillermo] NYU, Langone Med Ctr, Dept Microbiol, New York, NY 10016 USA. [Jernberg, Cecilia] Publ Hlth Agcy Sweden, S-17182 Solna, Sweden. [Merens, Audrey] Begin Mil Hosp, Dept Biol, F-94160 St Mande, France. [Merens, Audrey] Begin Mil Hosp, Infect Control Unit, F-94160 St Mande, France. [Page, Anne-Laure; Langendorf, Celine] Epicentre, F-75011 Paris, France. [Roggentin, Peter] Inst Hyg & Umwelt, D-20539 Hamburg, Germany. [Fruth, Angelika] Robert Koch Inst, Div Enteropathogen Bacteria & Legionella, D-38855 Wernigerode, Germany. [Denamur, Erick] Univ Paris Diderot, Sorbonne Paris Cite, INSERM, IAME,UMR 1137, F-75018 Paris, France. [Venkatesan, Malabi] Walter Reed Army Inst Res, Bacterial Dis Branch, Silver Spring, MD 20910 USA. [Bercovier, Herve] Hebrew Univ Jerusalem, Fac Med, IL-91120 Jerusalem, Israel. [Chiou, Chien-Shun] Ctr Dis Control, Ctr Res & Diagnost, Taichung 40855, Taiwan. [Colonna, Bianca] Sapienza Univ Roma, Dipartimento Biol & Biotecnol C Darwin, Inst Pasteur Fdn Cenci Bolognetti, I-00185 Rome, Italy. [Ezernitchi, Analia V.] Minist Hlth, Cent Labs, IL-91342 Jerusalem, Israel. [Guigon, Ghislaine; Brisse, Sylvain] Inst Pasteur, Genotyping Pathogens & Publ Hlth Platform, F-75724 Paris 15, France. [Izumiya, Hidemasa] Natl Inst Infect Dis, Dept Bacteriol 1, Tokyo 1628640, Japan. [Lutynska, Anna] Natl Inst Hyg, Natl Publ Hlth Inst, Dept Sera & Vaccines Evaluat, PL-00791 Warsaw, Poland. [Marejkova, Monika] Natl Inst Publ Hlth, Natl Reference Lab E Coli and Shigella, Prague 10, Czech Republic. [Peterson, Lorea A. M.] Publ Hlth Agcy Canada, Natl Microbiol Lab, Winnipeg, MB R3E 3R2, Canada. [Souche, Erika] Inst Pasteur, Bioinformat Platform, F-75724 Paris 15, France. [Ye, Changyun] China CDC, Natl Inst Communicable Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Beijing 102206, Peoples R China. [Zemlickova, Helena] Charles Univ Prague, Dept Clin Microbiol, Fac Med, Hradec Kralove 50005, Czech Republic. [Zemlickova, Helena] Charles Univ Prague, Univ Hosp, Hradec Kralove 50005, Czech Republic. [Herpay, Mria] Natl Ctr Epidemiol, Hungarian Natl Collect Med Bacteria, H-1097 Budapest, Hungary. [Sansonetti, Philippe] Inst Pasteur, Unite Pathogenie Microbienne Mol, F-75724 Paris 15, France. [Brisse, Sylvain] Inst Pasteur, Microbial Evolutionary Genom Unit, F-75724 Paris 15, France. [Brisse, Sylvain] CNRS, UMR 3525, F-75015 Paris, France. [Thomson, Nicholas R.] London Sch Hyg & Trop Med, London WC1E 7HT, England. EM fxweill@pasteur.fr OI Hawkey, Jane/0000-0001-9661-5293; Grimont, Patrick/0000-0002-6264-136X; Perez Perez, Guillermo /0000-0002-0131-5798; Korzeniowska-Kowal, Agnieszka/0000-0001-7569-8018 FU Institut Pasteur; Institut Pasteur International Network; Institut de Veille Sanitaire; French government's Investissement d'Avenir programme, Laboratoire d'Excellence 'Integrative Biology of Emerging Infectious Diseases' [ANR-10-LABX-62-IBEID]; Fondation 'Le Roch-Les Mousquetaires'; Canetti family through the Georges, Jacques et Elias Canetti Award; Wellcome Trust [098051]; NHMRC of Australia [1061409]; Victorian Life Sciences Computation Initiative (VLSCI) [VR0082]; Indian Council of Medical Research, New Delhi, India FX This study was supported by the Institut Pasteur and the Institut Pasteur International Network, the Institut de Veille Sanitaire, the French government's Investissement d'Avenir programme, Laboratoire d'Excellence 'Integrative Biology of Emerging Infectious Diseases' (grant no. ANR-10-LABX-62-IBEID), the Fondation 'Le Roch-Les Mousquetaires', the Canetti family through the Georges, Jacques et Elias Canetti Award 2013, the Wellcome Trust through grant 098051 to the Sanger Institute, the NHMRC of Australia (grant 1061409 to K.E.H), the Victorian Life Sciences Computation Initiative (VLSCI) (grant VR0082) and the Indian Council of Medical Research, New Delhi, India. The authors thank A. Dautry-Versat, A.P. Pugsley, C. Brechot and J. Savall fur their support; T. Hieu, C. Soto, E. Bourreterre and B. Faye for technical assistance; Z. Szabo, D. Tremblay for providing isolates; L.R. Hiltzik, N. Baldwin and C. Mackenzie for their searches of the archives; M. Toucas, H. d'Hauteville, E. Aldova, S. Formal, and A.T. Maurelli for information about isolates; D. Nedelec for discussion, I. Gut, M. Gut, L. Ma, D. Harris, K. Oliver and the sequencing teams at the Institut Pasteur and Wellcome Trust Sanger Institute for sequencing the samples. The views expressed in this publication are those of the authors and do not reflect the views of the US Department of the Army or Department of Defense. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 63 TC 3 Z9 3 U1 10 U2 10 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND EI 2058-5276 J9 NAT MICROBIOL JI NAT. MICROBIOL PD APR PY 2016 VL 1 IS 4 AR UNSP 16027 DI 10.1038/NMICROBIOL.2016.27 PG 9 WC Microbiology SC Microbiology GA DW4HY UT WOS:000383605000006 PM 27572446 ER PT J AU Barbato, RA Foley, KL LeWinter, A Finnegan, D Vecherin, S Anderson, JE Yamamoto, K Borden, C Fahy, E Calandra, N Reynolds, CM AF Barbato, Robyn A. Foley, Karen L. LeWinter, Adam Finnegan, David Vecherin, Sergey Anderson, John E. Yamamoto, Kenneth Borden, Christian Fahy, Ethan Calandra, Nathan Reynolds, Charles M. TI The Attenuation of Retroreflective Signatures on Surface Soils SO PHOTOGRAMMETRIC ENGINEERING AND REMOTE SENSING LA English DT Article ID LIDAR; BIODEGRADATION; CALIBRATION AB Soil parameters such as water potential, temperature, organic matter (OM), and particle size distribution influence biological activity and collectively define the state of soils, yet these properties are typically described through time-intensive, ground-based sampling efforts. To improve our understanding of soils through stand-off sensing techniques, Light Detection and Ranging was used to monitor the signature of retroreflective beads embedded in polymeric agents on four soils. Our goal was to generate probability density functions (PDFs) for stochastic predictions of the persistence of this signature through time. Our findings showed that the PDFs of the reflected signal between target and background soils became nearly indistinguishable after five months and that OM, nitrogen content, cation exchange capacity, and pH related to signature decline. This approach, while developed using polymer-bound retroreflectors, will serve as a framework where a signature-emitter is left in or on soil and differentially influenced by terrain, weather, and soil processes. C1 [Barbato, Robyn A.; Foley, Karen L.; LeWinter, Adam; Finnegan, David; Vecherin, Sergey; Yamamoto, Kenneth; Reynolds, Charles M.] US Army, ERDC Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. [Anderson, John E.] US Army, ERDC Geospatial Res Lab, 1000 W Cary St,VCU Acad Campus, Richmond, VA 23284 USA. [Borden, Christian; Fahy, Ethan; Calandra, Nathan] Atmospher & Environm Res, 131 Hartwell Ave, Lexington, MA 02421 USA. RP Barbato, RA (reprint author), US Army, ERDC Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM Robyn.A.Barbato@erdc.dren.mil FU US Army Engineer Research and Development Center, Applied Research Program Office FX Three anonymous reviewers contributed greatly to the improvement of the manuscript. This work was funded through the US Army Engineer Research and Development Center, Applied Research Program Office. Permission for publishing this information has been granted by the Chief of Engineers. NR 33 TC 1 Z9 1 U1 2 U2 2 PU AMER SOC PHOTOGRAMMETRY PI BETHESDA PA 5410 GROSVENOR LANE SUITE 210, BETHESDA, MD 20814-2160 USA SN 0099-1112 EI 2374-8079 J9 PHOTOGRAMM ENG REM S JI Photogramm. Eng. Remote Sens. PD APR PY 2016 VL 82 IS 4 BP 283 EP 289 DI 10.14358/PERS.82.4.283 PG 7 WC Geography, Physical; Geosciences, Multidisciplinary; Remote Sensing; Imaging Science & Photographic Technology SC Physical Geography; Geology; Remote Sensing; Imaging Science & Photographic Technology GA DX0LZ UT WOS:000384055000009 ER PT J AU Manning, T Field, R Klingaman, K Fair, M Bolognini, J Crownover, R Adam, CP Panchal, V Rozumov, E Grau, H Matter, P Beachy, M Holt, C Sopok, S AF Manning, Thelma Field, Richard Klingaman, Kenneth Fair, Michael Bolognini, John Crownover, Robin Adam, Carlton P. Panchal, Viral Rozumov, Eugene Grau, Henry Matter, Paul Beachy, Michael Holt, Christopher Sopok, Samuel TI Innovative boron nitride-doped propellants SO DEFENCE TECHNOLOGY LA English DT Article DE Nano-boron nitride; Additive; Lubricant; Gun barrel; Wear and erosion; Gun propellant ID BEHAVIOR; STEELS AB The U.S. military has a need for more powerful propellants with balanced/stoichiometric amounts of fuel and oxidants. However, balanced and more powerful propellants lead to accelerated gun barrel erosion and markedly shortened useful barrel life. Boron nitride (BN) is an interesting potential additive for propellants that could reduce gun wear effects in advanced propellants (US patent pending 2015-026P). Hexagonal boron nitride is a good lubricant that can provide wear resistance and lower flame temperatures for gun barrels. Further, boron can dope steel, which drastically improves its strength and wear resistance, and can block the formation of softer carbides. A scalable synthesis method for producing boron nitride nano-particles that can be readily dispersed into propellants has been developed. Even dispersion of the nano-particles in a double-base propellant has been demonstrated using a solvent-based processing approach. Stability of a composite propellant with the BN additive was verified. In this paper, results from propellant testing of boron nitride nano-composite propellants are presented, including closed bomb and wear and erosion testing. Detailed characterization of the erosion tester substrates before and after firing was obtained by electron microscopy, inductively coupled plasma and x-ray photoelectron spectroscopy. This promising boron nitride additive shows the ability to improve gun wear and erosion resistance without any destabilizing effects to the propellant. Potential applications could include less erosive propellants in propellant ammunition for large, medium and small diameter fire arms. Production and hosting by Elsevier B.V. on behalf of China Ordnance Society. C1 [Manning, Thelma; Field, Richard; Klingaman, Kenneth; Fair, Michael; Bolognini, John; Crownover, Robin; Adam, Carlton P.; Panchal, Viral; Rozumov, Eugene; Grau, Henry] US Army RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA. [Matter, Paul; Beachy, Michael; Holt, Christopher] PH Matter LLC, Columbus, OH USA. [Sopok, Samuel] Benet Lab, Watervliet, NY USA. RP Manning, T (reprint author), US Army RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA. EM thelma.g.manning.civ@mail.mil NR 13 TC 1 Z9 1 U1 4 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 2214-9147 J9 DEF TECHNOL JI Def. Technol. PD APR PY 2016 VL 12 IS 2 BP 69 EP 80 DI 10.1016/j.dt.2015.10.001 PG 12 WC Engineering, Multidisciplinary SC Engineering GA DV8NG UT WOS:000383193100003 ER PT J AU Malbec, LM Eagle, WE Musculus, MPB Schihl, P AF Malbec, Louis-Marie Eagle, W. Ethan Musculus, Mark P. B. Schihl, Peter TI Influence of Injection Duration and Ambient Temperature on the Ignition Delay in a 2.34L Optical Diesel Engine SO SAE INTERNATIONAL JOURNAL OF ENGINES LA English DT Article ID NON-PREMIXED FLAMES; HIGH-PRESSURE; AUTOIGNITION CHARACTERISTICS; NUMERICAL SIMULATIONS; NOZZLE GEOMETRY; TURBULENT JETS; MOMENTUM FLUX; LIFT-OFF; COMBUSTION; FUEL AB Non-conventional operating conditions and fuels in diesel engines can produce longer ignition delays compared to conventional diesel combustion. If those extended delays are longer than the injection duration, the ignition and combustion progress can be significantly influenced by the transient following the end of injection (EOI), and especially by the modification of the mixture field. The objective of this paper is to assess how those long ignition delays, obtained by injecting at low in-cylinder temperatures (e.g., 760-800K), are affected by EOI. Two multi-hole diesel fuel injectors with either six 0.20mm orifices or seven 0.14mm orifices have been used in a 2.34L single-cylinder optical diesel engine. We consider a range of ambient top dead center (TDC) temperatures at the start of injection from 760-1000K as well as a range of injection durations from 0.5ms to 3.1ms. Ignition delays are computed through the analysis of both cylinder pressure and chemiluminescence imaging. A simplified one-dimensional (1-d) model of the diesel jet, able to match the behavior of a transient injection and entrainment processes, is used to estimate the ensemble-averaged mixture fraction fields during the injection event and at the ignition kernel locations. At TDC temperatures of 850K or higher, the injection duration is longer than ignition delay, and thus EOI has no effect on ignition delay. At TDC temperatures of 800K or lower, for short injection durations (<1.3ms), ignition occurs after EOI and ignition delay decreases with decreasing injection duration is observed. In addition, the 1-d spray model predicts a decrease of the mixture fraction at ignition kernels with decreasing ignition delay. This is in contrast to the expected trend of increasing kinetic time with decreasing mixture fraction for well-mixed reactors. This suggests that mixture fraction alone is not the first-order parameter influencing the timing and position of ignition sites. The history of the ignition kernel(s) and/or of the scalar dissipation may also need to be considered. C1 [Malbec, Louis-Marie] IFP Energies Nouvelles, Rueil Malmaison, France. [Eagle, W. Ethan; Musculus, Mark P. B.] Sandia Natl Labs, Livermore, CA 94550 USA. [Schihl, Peter] US Army, TARDEC, Warren, MI USA. RP Malbec, LM (reprint author), IFP Energies Nouvelles, Rueil Malmaison, France. NR 59 TC 0 Z9 0 U1 2 U2 2 PU SAE INT PI WARRENDALE PA 400 COMMONWEALTH DR, WARRENDALE, PA 15096 USA SN 1946-3936 EI 1946-3944 J9 SAE INT J ENGINES JI SAE Int. J. Engines PD APR PY 2016 VL 9 IS 1 BP 47 EP 70 DI 10.4271/2015-01-1830 PG 24 WC Transportation Science & Technology SC Transportation GA DU4NH UT WOS:000382189300005 ER PT J AU Johnson, ZA Ryan, PM Anderson, CD AF Johnson, Zackary A. Ryan, Paul M. Anderson, Claude D. TI Arthroscopic Stabilization for Chronic Latent Syndesmotic Instability SO ARTHROSCOPY TECHNIQUES LA English DT Article ID DISTAL TIBIOFIBULAR SYNDESMOSIS AB Subtle syndesmotic instability not evident on radiography can result in chronic ankle pain. The diagnosis is uncommon, and arthroscopic evaluation remains the gold standard for diagnosis. Definitive surgical management can be performed at the time of diagnosis. Patients with 2 to 4 mm of diastasis of the syndesmosis or translation can be treated with debridement alone, and patients with 4 mm or more of diastasis or translation can be treated with arthroscopic debridement and reduction followed by percutaneous stabilization. Percutaneous stabilization is accomplished by a TightRope technique, which involves passing 1 or 2 suture buttons through all 4 cortices of the distal tibia and fibula. This technique is used in lieu of the traditional syndesmotic screw, which requires a subsequent operation for removal. C1 [Johnson, Zackary A.; Ryan, Paul M.; Anderson, Claude D.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Johnson, ZA (reprint author), 44-150 Kou Pl,5, Kaneohe, HI 96744 USA. EM ZackJ83@gmail.com OI Anderson, Christopher/0000-0002-0053-2002 NR 8 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 2212-6287 J9 ARTHROSC TEC JI Arthrosc. Tec. PD APR PY 2016 VL 5 IS 2 BP E263 EP E268 DI 10.1016/j.eats.2015.12.006 PG 6 WC Orthopedics SC Orthopedics GA DU5EO UT WOS:000382235200009 PM 27354945 ER PT J AU Blackley, DJ Wiley, MR Ladner, JT Fallah, M Lo, T Gilbert, ML Gregory, C D'ambrozio, J Coulter, S Mate, S Balogun, Z Kugelman, J Nwachukwu, W Prieto, K Yeiah, A Amegashie, F Kearney, B Wisniewski, M Saindon, J Schroth, G Fakoli, L Diclaro, JW Kuhn, JH Hensley, LE Jahrling, PB Stroher, U Nichol, ST Massaquoi, M Kateh, F Clement, P Gasasira, A Bolay, F Monroe, SS Rambaut, A Sanchez-Lockhart, M Laney, AS Nyenswah, T Christie, A Palacios, G AF Blackley, David J. Wiley, Michael R. Ladner, Jason T. Fallah, Mosoka Lo, Terrence Gilbert, Merle L. Gregory, Christopher D'ambrozio, Jonathan Coulter, Stewart Mate, Suzanne Balogun, Zephaniah Kugelman, Jeffrey Nwachukwu, William Prieto, Karla Yeiah, Adolphus Amegashie, Fred Kearney, Brian Wisniewski, Meagan Saindon, John Schroth, Gary Fakoli, Lawrence Diclaro, Joseph W., II Kuhn, Jens H. Hensley, Lisa E. Jahrling, Peter B. Stroher, Ute Nichol, Stuart T. Massaquoi, Moses Kateh, Francis Clement, Peter Gasasira, Alex Bolay, Fatorma Monroe, Stephan S. Rambaut, Andrew Sanchez-Lockhart, Mariano Laney, A. Scott Nyenswah, Tolbert Christie, Athalia Palacios, Gustavo TI Reduced evolutionary rate in reemerged Ebola virus transmission chains SO SCIENCE ADVANCES LA English DT Article ID LIBERIA; SURVEILLANCE; OUTBREAK; SPREAD AB On 29 June 2015, Liberia's respite from Ebola virus disease (EVD) was interrupted for the second time by a renewed outbreak ("flare-up") of seven confirmed cases. We demonstrate that, similar to the March 2015 flare-up associated with sexual transmission, this new flare-up was a reemergence of a Liberian transmission chain originating from a persistently infected source rather than a reintroduction from a reservoir or a neighboring country with active transmission. Although distinct, Ebola virus (EBOV) genomes from both flare-ups exhibit significantly low genetic divergence, indicating a reduced rate of EBOV evolution during persistent infection. Using this rate of change as a signature, we identified two additional EVD clusters that possibly arose from persistently infected sources. These findings highlight the risk of EVD flare-ups even after an outbreak is declared over. C1 [Blackley, David J.; Lo, Terrence; Gregory, Christopher; Coulter, Stewart; Balogun, Zephaniah; Nwachukwu, William; Saindon, John; Stroher, Ute; Monroe, Stephan S.; Laney, A. Scott; Christie, Athalia] Ctr Dis Control & Prevent, Atlanta, GA 30329 USA. [Wiley, Michael R.; Ladner, Jason T.; Gilbert, Merle L.; D'ambrozio, Jonathan; Mate, Suzanne; Kugelman, Jeffrey; Prieto, Karla; Kearney, Brian; Wisniewski, Meagan; Sanchez-Lockhart, Mariano; Palacios, Gustavo] US Army, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Fallah, Mosoka; Yeiah, Adolphus; Amegashie, Fred; Massaquoi, Moses; Kateh, Francis; Nyenswah, Tolbert] Minist Hlth, Monrovia, Liberia. [Schroth, Gary] Illumina Inc, San Diego, CA 92122 USA. [Fakoli, Lawrence; Bolay, Fatorma] Liberian Inst Biomed Res, Charlesville, Liberia. [Diclaro, Joseph W., II] US Navy, Naval Med Res Unit 3, Cairo, Egypt. [Kuhn, Jens H.; Hensley, Lisa E.; Jahrling, Peter B.; Nichol, Stuart T.] NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD 21702 USA. [Clement, Peter; Gasasira, Alex] WHO, CH-1211 Geneva 27, Switzerland. [Rambaut, Andrew] Univ Edinburgh, Inst Evolutionary Biol, Edinburgh EH9 3FL, Midlothian, Scotland. [Rambaut, Andrew] NIH, Fogarty Int Ctr, Bldg 10, Bethesda, MD 20892 USA. [Rambaut, Andrew] Univ Edinburgh, Ctr Immunol Infect & Evolut, Edinburgh EH9 3FL, Midlothian, Scotland. RP Christie, A (reprint author), Ctr Dis Control & Prevent, Atlanta, GA 30329 USA.; Palacios, G (reprint author), US Army, Med Res Inst Infect Dis, Frederick, MD 21702 USA.; Nyenswah, T (reprint author), Minist Hlth, Monrovia, Liberia. EM tgnyenswah74@yahoo.com; akc9@cdc.gov; gustavo.f.palacios.ctr@mail.mil RI Palacios, Gustavo/I-7773-2015 OI Palacios, Gustavo/0000-0001-5062-1938 FU NIAID NIH HHS [HHSN272200700016I]; PHS HHS [HHSN272200700016I] NR 25 TC 7 Z9 7 U1 1 U2 3 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 2375-2548 J9 SCI ADV JI Sci. Adv. PD APR PY 2016 VL 2 IS 4 AR e1600378 DI 10.1126/sciadv.1600378 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DR7IB UT WOS:000380072100053 PM 27386513 ER PT J AU Giuntini, D Raethel, J Herrmann, M Michaelis, A Haines, CD Olevsky, EA AF Giuntini, Diletta Raethel, Jan Herrmann, Mathias Michaelis, Alexander Haines, Christopher D. Olevsky, Eugene A. TI Spark plasma sintering novel tooling design: temperature uniformization during consolidation of silicon nitride powder SO JOURNAL OF THE CERAMIC SOCIETY OF JAPAN LA English DT Article DE Spark plasma sintering; Field-assisted sintering techniques; Tooling; Finite-element modeling; Silicon nitride ID STRESS DISTRIBUTIONS; FUNDAMENTAL-ASPECTS; ELECTRIC-FIELD; CERAMICS; OPTIMIZATION; SCALABILITY; COMPOSITES; MECHANISMS; SIMULATION; EVOLUTION AB Spark Plasma Sintering (SPS) of silicon nitride is affected by temperature non-uniformities within the powder compact, resulting in density and microstructure inhomogeneities. A double-pyrometer experimental setup reveals a temperature disparity of 100-200 degrees C between the overheated outer surface of the die and the bottom of the upper punch, as a consequence of the electric current concentration through the die's wall characterizing the SPS of non-conductive powders utilizing conventional SPS tooling. A novel tooling design, consisting in the tailored drilling of axial cylindrical or ring-shaped holes within the punch, is individuated and optimized through a campaign of fully-coupled thermal, electrical and mechanical finite element simulations. The analysis of the numerical results, experimentally assessed, allows for a comprehensive understanding of the phenomena underlying radial temperature distributions in SPS and leads to the development of a technological solution for the uniformization of temperature distribution. (C) 2016 The Ceramic Society of Japan. All rights reserved. C1 [Giuntini, Diletta; Olevsky, Eugene A.] San Diego State Univ, 5500 Campanile Dr, San Diego, CA 92182 USA. [Raethel, Jan; Herrmann, Mathias; Michaelis, Alexander] Fraunhofer Inst Ceram Technol & Syst IKTS, Winterbergstr 28, D-01277 Dresden, Germany. [Haines, Christopher D.] US Army ARDEC, Picatinny Arsenal, NJ 07806 USA. RP Giuntini, D (reprint author), San Diego State Univ, 5500 Campanile Dr, San Diego, CA 92182 USA. EM dgiuntini@mail.sdsu.edu RI Michaelis, Alexander/R-9240-2016; OI Michaelis, Alexander/0000-0002-5987-1252; Herrmann, Mathias/0000-0003-3264-8672 FU US ARDEC, Picatinny Arsenal [W15QKN-14-C-0068]; US Department of Energy, Materials Sciences Division [DE-SC0008581] FX The support of US ARDEC, Picatinny Arsenal (Contract Award #W15QKN-14-C-0068) is gratefully appreciated. The support of the US Department of Energy, Materials Sciences Division, under Award No. DE-SC0008581 is gratefully acknowledged. NR 57 TC 1 Z9 1 U1 1 U2 2 PU CERAMIC SOC JAPAN-NIPPON SERAMIKKUSU KYOKAI PI TOKYO PA 22-17, HYAKUNIN-CHO 2-CHOME, SHINJUKU-KU, TOKYO, 169-0073, JAPAN SN 1882-0743 EI 1348-6535 J9 J CERAM SOC JPN JI J. Ceram. Soc. Jpn. PD APR PY 2016 VL 124 IS 4 BP 403 EP 414 DI 10.2109/jcersj2.15213 PG 12 WC Materials Science, Ceramics SC Materials Science GA DR0PT UT WOS:000379610100021 ER PT J AU Andrews, NA Latremoliere, A Basbaum, AI Mogil, JS Porreca, F Rice, ASC Woolf, CJ Currie, GL Dworkin, RH Eisenach, JC Evans, S Gewandter, JS Gover, TD Handwerker, H Huang, W Iyengar, S Jensen, MP Kennedy, JD Lee, N Levine, J Lidster, K Machin, I McDermott, MP McMahon, SB Price, TJ Ross, SE Scherrer, G Seal, RP Sena, ES Silva, E Stone, L Svensson, CI Turk, DC Whiteside, G AF Andrews, Nick A. Latremoliere, Alban Basbaum, Allan I. Mogil, Jeffrey S. Porreca, Frank Rice, Andrew S. C. Woolf, Clifford J. Currie, Gillian L. Dworkin, Robert H. Eisenach, James C. Evans, Scott Gewandter, Jennifer S. Gover, Tony D. Handwerker, Hermann Huang, Wenlong Iyengar, Smriti Jensen, Mark P. Kennedy, Jeffrey D. Lee, Nancy Levine, Jon Lidster, Katie Machin, Ian McDermott, Michael P. McMahon, Stephen B. Price, Theodore J. Ross, Sarah E. Scherrer, Gregory Seal, Rebecca P. Sena, Emily S. Silva, Elizabeth Stone, Laura Svensson, Camilla I. Turk, Dennis C. Whiteside, Garth TI Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations SO PAIN LA English DT Article DE Transparent reporting; Consensus; Bias; Internal validity ID CLINICAL-TRIALS; ANIMAL-MODELS; MULTIPLICITY; STANDARDS; DRUGS; CALL AB There is growing concern about lack of scientific rigor and transparent reporting across many preclinical fields of biological research. Poor experimental design and lack of transparent reporting can result in conscious or unconscious experimental bias, producing results that are not replicable. The Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) public-private partnership with the U.S. Food and Drug Administration sponsored a consensus meeting of the Preclinical Pain Research Consortium for Investigating Safety and Efficacy (PPRECISE) Working Group. International participants from universities, funding agencies, government agencies, industry, and a patient advocacy organization attended. Reduction of publication bias, increasing the ability of others to faithfully repeat experimental methods, and increased transparency of data reporting were specifically discussed. Parameters deemed essential to increase confidence in the published literature were clear, specific reporting of an a priori hypothesis and definition of primary outcome measure. Power calculations and whether measurement of minimal meaningful effect size to determine these should be a core component of the preclinical research effort provoked considerable discussion, with many but not all agreeing. Greater transparency of reporting should be driven by scientists, journal editors, reviewers, and grant funders. The conduct of high-quality science that is fully reported should not preclude novelty and innovation in preclinical pain research, and indeed, any efforts that curtail such innovation would be misguided. We believe that to achieve the goal of finding effective new treatments for patients with pain, the pain field needs to deal with these challenging issues. C1 [Andrews, Nick A.; Latremoliere, Alban; Woolf, Clifford J.] Harvard Univ, Sch Med, Boston Childrens Hosp, Dept Neurobiol, 3 Blackfan Circle, Boston, MA 02115 USA. [Basbaum, Allan I.] Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA. [Mogil, Jeffrey S.] McGill Univ, Dept Psychol, Montreal, PQ, Canada. [Mogil, Jeffrey S.] McGill Univ, Alan Edwards Ctr Res Pain, Montreal, PQ, Canada. [Porreca, Frank] Univ Arizona, Coll Med, Dept Pharmacol, Tucson, AZ 85724 USA. [Rice, Andrew S. C.] Univ London Imperial Coll Sci Technol & Med, Dept Surg & Canc, Pain Res, London, England. [Currie, Gillian L.; Sena, Emily S.] Univ Edinburgh, Ctr Clin Brain Sci, Edinburgh, Midlothian, Scotland. [Dworkin, Robert H.; Gewandter, Jennifer S.] Univ Rochester, Dept Anesthesiol, Rochester, NY USA. [Dworkin, Robert H.; McDermott, Michael P.] Univ Rochester, Dept Neurol, Rochester, NY USA. [Dworkin, Robert H.] Univ Rochester, Dept Psychiat, Rochester, NY USA. [Eisenach, James C.] Wake Forest Sch Med, Dept Anesthesiol, Winston Salem, NC USA. [Evans, Scott] Harvard Univ, Dept Biostat, 3 Blackfan Circle, Boston, MA 02115 USA. [Gover, Tony D.] US Army Med Res & Mat Command, Clin & Rehabilitat Med Res Program, Ft Detrick, MD USA. [Handwerker, Hermann] Univ Erlangen Nurnberg, Dept Physiol & Pathophysiol, Erlangen, Germany. [Huang, Wenlong] Univ Aberdeen, Inst Med Sci, Aberdeen, Scotland. [Iyengar, Smriti] Eli Lilly & Co, Indianapolis, IN 46285 USA. [Jensen, Mark P.] Univ Washington, Dept Rehabil Med, Seattle, WA 98195 USA. [Kennedy, Jeffrey D.] Eli Lilly & Co, Neurosci Discovery Res, Indianapolis, IN 46285 USA. [Lee, Nancy] Wellcome Trust Res Labs, Policy Dept, London, England. [Levine, Jon] Univ Calif San Francisco, Dept Med, San Francisco, CA USA. [Levine, Jon] Univ Calif San Francisco, Dept Oral Surg, San Francisco, CA USA. [Lidster, Katie] Natl Ctr Replacement Refinement & Reduct Anim Res, London, England. [McDermott, Michael P.] Univ Rochester, Dept Biostat & Computat Biol, Rochester, NY USA. [McMahon, Stephen B.] Kings Coll London, Neurorestorat Grp, London, England. [Price, Theodore J.] Univ Texas Dallas, Sch Behav & Brain Sci, Dallas, TX 75230 USA. [Ross, Sarah E.] Univ Pittsburgh, Dept Neurobiol, Pittsburgh, PA USA. [Scherrer, Gregory] Stanford Univ, Sch Med, Dept Anesthesiol Perioperat & Pain Med, Palo Alto, CA 94304 USA. [Seal, Rebecca P.] Univ Calif San Francisco, Off Career & Profess Dev, San Francisco, CA 94143 USA. [Silva, Elizabeth] McGill Univ, Fac Dent, Montreal, PQ, Canada. [Stone, Laura] McGill Univ, Alan Edwards Ctr Res Pain, Montreal, PQ, Canada. [Svensson, Camilla I.] Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden. [Turk, Dennis C.] Univ Washington, Dept Anesthesiol & Pain Med, Seattle, WA 98195 USA. [Whiteside, Garth] Purdue Pharma, Discovery Res, Cranbury, NJ USA. RP Andrews, NA (reprint author), Harvard Univ, Sch Med, Boston Childrens Hosp, Kirby Neurobiol Ctr, 3 Blackfan Circle, Boston, MA 02115 USA. EM Nick.andrews@childrens.harvard.edu RI Huang, Wenlong/P-2025-2016; OI Silva, Elizabeth/0000-0002-0684-9473; Sena, Emily S/0000-0002-3282-8502; Scherrer, Gregory/0000-0002-1983-5126 FU Analgesic; Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION); Anesthetic; Food and Drug Administration (FDA); ACTTION; FDA FX The findings, conclusions, and recommendations in this article are solely those of the authors, none of whom have financial conflicts of interest specifically related to the issues discussed in this article. At the time of the consensus meeting on which this article is based, 3 authors were employed by pharmaceutical companies and others had received consulting fees or honoraria from one or more pharmaceutical or device companies. Authors of this article who were not employed by industry or government at the time of the consensus meeting received travel stipends, hotel accommodations, and meals during the meeting from the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) public-private partnership. No official endorsement by the Food and Drug Administration (FDA) or the pharmaceutical and device companies that have provided unrestricted grants to support the activities of ACTTION should be inferred. Financial support for this project was provided by ACTTION, which has received research contracts, grants, or other revenue from the FDA, multiple pharmaceutical and device companies, and other sources. NR 19 TC 2 Z9 2 U1 1 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0304-3959 EI 1872-6623 J9 PAIN JI Pain PD APR PY 2016 VL 157 IS 4 BP 901 EP 909 DI 10.1097/j.pain.0000000000000458 PG 9 WC Anesthesiology; Clinical Neurology; Neurosciences SC Anesthesiology; Neurosciences & Neurology GA DP1PJ UT WOS:000378261600017 PM 26683237 ER PT J AU Paech, GM Della Vedova, C Pajcin, M Grant, C Kamimori, G Banks, S AF Paech, Gemma M. Della Vedova, Chris Pajcin, Maja Grant, Crystal Kamimori, Gary Banks, Siobhan TI Caffeine has minimal effects on daytime recovery sleep following severe sleep deprivation SO SLEEP AND BIOLOGICAL RHYTHMS LA English DT Article DE Total sleep deprivation; Sleep structure; Fatigue countermeasures; Stimulants; Daytime recovery ID PERFORMANCE; ALERTNESS; HUMANS; METABOLISM; ADENOSINE; BIOAVAILABILITY; HOMEOSTASIS; MODAFINIL; COFFEE; BRAIN AB Caffeine has been shown to minimise the effects of sleep loss on performance and alertness. However, caffeine may also have negative repercussions for recovery sleep, particularly during the daytime. The current study investigated the impact of high caffeine consumption on daytime recovery sleep following 50 h wakefulness. Twenty-four healthy participants were randomly assigned to either a caffeine (n = 12, aged 22.5 +/- 3.3 years) or placebo condition (n = 12, aged 22.5 +/- 2.5 years). All participants were scheduled to one baseline sleep (22:00-08:00 h) and two nights (50 h) of wakefulness followed by a daytime recovery sleep (10:00-19:00 h). Each night at 01:00, 03:00, 05:00 and 07:00 h during the wake period participants were given 200 mg of caffeine or placebo gum. Caffeine reduced the amount of SWS within the first NREM-REM sleep cycles compared to placebo. However, there were no differences between the caffeine and placebo conditions with relation to the overall amount of SWS, REM sleep, stage 2 sleep, and sleep initiation and consolidation during the recovery sleep. Results suggest that caffeine can be used as a fatigue countermeasure in industries where work hours extend to 50 h without significantly disrupting recovery sleep, even during the daytime. Results may also have implications for workers working extended shifts who use caffeine to help reduce fatigue during the commute home. C1 [Paech, Gemma M.; Banks, Siobhan] Univ S Australia, Ctr Sleep Res, Adelaide, SA 5001, Australia. [Paech, Gemma M.; Grant, Crystal] Washington State Univ, Sleep & Performance Res Ctr, POB 1495, Spokane, WA 99210 USA. [Della Vedova, Chris; Pajcin, Maja] Univ S Australia, Sch Pharm & Med Sci, Adelaide, SA 5001, Australia. [Kamimori, Gary] Walter Reed Army Inst Res, Behav Biol Branch, Silver Spring, MD USA. RP Paech, GM (reprint author), Univ S Australia, Ctr Sleep Res, Adelaide, SA 5001, Australia.; Paech, GM (reprint author), Washington State Univ, Sleep & Performance Res Ctr, POB 1495, Spokane, WA 99210 USA. EM gemma.paech@wsu.edu RI Della Vedova, Chris/F-4583-2013; Banks, Siobhan/L-2149-2013 OI Della Vedova, Chris/0000-0002-2361-3729; Banks, Siobhan/0000-0002-7489-0929 FU Defence Science and Technology Organisation, Australian Government, Department of Defence; US Army Medical Research and Material Command FX The authors thank participants and staff who helped with data collection, in particular Katja Morsky, Charitha Sayakkarage, Megan Dittman and Dong Jae Ryoo for taking biological samples throughout the study. We would also like to thank Kayla Johnson, Glen Pierce, Philip Jacques, Justin Fidock and Stephanie Eonta. This work was supported by the Defence Science and Technology Organisation, Australian Government, Department of Defence. This work was also supported by the US Army Medical Research and Material Command. This material has been reviewed by the Walter Reed Army Institute of Research, and there is no objection to its presentation and/or publication. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the position of the Department of the Army of the Department of Defence. NR 39 TC 0 Z9 0 U1 12 U2 12 PU SPRINGER LONDON LTD PI LONDON PA 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND SN 1446-9235 EI 1479-8425 J9 SLEEP BIOL RHYTHMS JI Sleep Biol. Rhythms PD APR PY 2016 VL 14 IS 2 BP 149 EP 156 DI 10.1007/s41105-015-0031-9 PG 8 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA DP0AO UT WOS:000378150200005 ER PT J AU Goldman, SB Wolff, A Root, L AF Goldman, Sarah B. Wolff, Aviva Root, Leon TI Special Issue: Wrist SO JOURNAL OF HAND THERAPY LA English DT Editorial Material C1 [Goldman, Sarah B.] US Army, Off Surgeon Gen, Oklahoma City, OK USA. [Wolff, Aviva; Root, Leon] Hosp Special Surg, Mot Anal Lab, New York, NY USA. RP Goldman, SB (reprint author), Off Surgeon Gen, 7700 Arlington Blvd, Falls Church, VA 22042 USA. EM sarah.b.goldman.mil@mail.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU HANLEY & BELFUS-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0894-1130 EI 1545-004X J9 J HAND THER JI J. Hand Ther. PD APR-JUN PY 2016 VL 29 IS 2 BP 95 EP 95 DI 10.1016/j.jht.2016.04.004 PG 1 WC Orthopedics; Rehabilitation; Surgery SC Orthopedics; Rehabilitation; Surgery GA DO8GG UT WOS:000378020600001 PM 27264895 ER PT J AU Smith, AN Jankowski, NR Boteler, LM AF Smith, Andrew N. Jankowski, Nicholas R. Boteler, Lauren M. TI Measurement of High-Performance Thermal Interfaces Using a Reduced Scale Steady-State Tester and Infrared Microscopy SO JOURNAL OF HEAT TRANSFER-TRANSACTIONS OF THE ASME LA English DT Article DE thermal interface resistance; thermal interface materials; contact resistance; infrared microscopy; heat transfer ID CARBON NANOTUBE ARRAYS; NANOCOMPOSITES AB Thermal interface materials (TIMs) have reached values approaching the measurement uncertainty of standard ASTM D5470 based testers of approximately +/- 1 x 10(-6) m(2) K/W. This paper presents a miniature ASTM/type steady-state tester that was developed to address the resolution limits of standard testers by reducing the heat meter bar thickness and using infrared (IR) thermography to measure the temperature gradient along the heat meter bar. Thermal interfacial resistance measurements on the order of 1 x 10(-6) m(2) K/W with an order of magnitude improvement in the uncertainty of +/- 1 x 10(-7) m(2) K/W are demonstrated. These measurements were made on several TIMs with a thermal resistance as low as 1.14 x 10(-6) m(2) K/W. C1 [Smith, Andrew N.] US Naval Acad, Annapolis, MD 21402 USA. [Jankowski, Nicholas R.; Boteler, Lauren M.] US Army Res Lab, Adelphi, MD 20783 USA. RP Smith, AN (reprint author), US Naval Acad, Annapolis, MD 21402 USA. EM ansmith@usna.edu; nicholas.r.jankowski.civ@mail.mil; lauren.m.boteler.civ@mail.mil NR 23 TC 2 Z9 2 U1 1 U2 1 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0022-1481 EI 1528-8943 J9 J HEAT TRANS-T ASME JI J. Heat Transf.-Trans. ASME PD APR PY 2016 VL 138 IS 4 AR 041301 DI 10.1115/1.4032172 PG 7 WC Thermodynamics; Engineering, Mechanical SC Thermodynamics; Engineering GA DO8XB UT WOS:000378067700001 ER PT J AU Ladner, JT Kuhn, JH Palacios, G AF Ladner, J. T. Kuhn, J. H. Palacios, G. TI Standard finishing categories for high-throughput sequencing of viral genomes SO REVUE SCIENTIFIQUE ET TECHNIQUE-OFFICE INTERNATIONAL DES EPIZOOTIES LA English DT Article DE Data curation; Genome assembly; High-throughput sequencing; Medical countermeasure development; Molecular epidemiology; Population genomics; Virus ID EBOLA-VIRUS; DIVERSITY; EVOLUTION; DISCOVERY; VARIANTS; SURVEILLANCE; CORONAVIRUS; POPULATION; EMERGENCE; EPIDEMIC AB Viral genome sequencing has become the cornerstone of almost all aspects of virology. In particular, high-throughput, next-generation viral genome sequencing has become an integral part of molecular epidemiological investigations into outbreaks of viral disease, such as the recent outbreaks of Middle Eastern respiratory syndrome, Ebola virus disease and Zika virus infection. Multiple institutes have acquired the expertise and necessary infrastructure to perform such investigations, as evidenced by the accumulation of thousands of novel viral sequences over progressively shorter time periods. The authors recently proposed a nomenclature comprised of five high-throughput sequencing standard categories to describe the quality of determined viral genome sequences. These five categories (standard draft, high quality, coding complete, complete and finished) cover all levels of viral genome finishing and can be applied to sequences determined by any technology platform or assembly technique. C1 [Ladner, J. T.; Palacios, G.] US Army, Med Res Inst Infect Dis, Ctr Genome Sci, Frederick, MD 21702 USA. [Kuhn, J. H.] NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD USA. RP Palacios, G (reprint author), US Army, Med Res Inst Infect Dis, Ctr Genome Sci, Frederick, MD 21702 USA. EM gustavo.f.palacios.ctr@mail.mil RI Palacios, Gustavo/I-7773-2015 OI Palacios, Gustavo/0000-0001-5062-1938 FU Defense Threat Reduction Agency [1881290]; Battelle Memorial Institute's prime contract; US National Institute of Allergy and Infectious Diseases [HHSN272200700016I] FX This work was partly funded by Defense Threat Reduction Agency Project No. 1881290 and by Battelle Memorial Institute's prime contract with the US National Institute of Allergy and Infectious Diseases under Contract No. HHSN272200700016I. A subcontractor who performed this work is JHK, an employee of Tunnell Government Services. The authors thank Laura Bollinger for editing this manuscript. NR 42 TC 1 Z9 1 U1 42 U2 46 PU OFFICE INT EPIZOOTIES PI PARIS PA 12 RUE DE PRONY, 75017 PARIS, FRANCE SN 0253-1933 J9 REV SCI TECH OIE JI Rev. Sci. Tech. Off. Int. Epizoot. PD APR PY 2016 VL 35 IS 1 BP 43 EP 52 DI 10.20506/rst.35.1.2416 PG 10 WC Veterinary Sciences SC Veterinary Sciences GA DO8EA UT WOS:000378014200004 PM 27217167 ER PT J AU McFall, BC Fritz, HM AF McFall, Brian C. Fritz, Hermann M. TI Physical modelling of tsunamis generated by three-dimensional deformable granular landslides on planar and conical island slopes SO PROCEEDINGS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES LA English DT Article DE landslide; tsunami; physical model; wave generation ID IMPULSE WAVES; UNDERWATER LANDSLIDES; NUMERICAL SIMULATIONS; SUBAERIAL LANDSLIDES; CIRCULAR ISLAND; WESTERN NORWAY; SOLITARY WAVES; WATER-WAVES; SLIDE; SUBMARINE AB Tsunamis generated by landslides and volcanic island collapses account for some of the most catastrophic events recorded, yet critically important field data related to the landslide motion and tsunami evolution remain lacking. Landslide-generated tsunami source and propagation scenarios are physically modelled in a three-dimensional tsunami wave basin. A unique pneumatic landslide tsunami generator was deployed to simulate landslides with varying geometry and kinematics. The landslides were generated on a planar hill slope and divergent convex conical hill slope to study lateral hill slope effects on the wave characteristics. The leading wave crest amplitude generated on a planar hill slope is larger on average than the leading wave crest generated on a convex conical hill slope, whereas the leading wave trough and second wave crest amplitudes are smaller. Between 1% and 24% of the landslide kinetic energy is transferred into the wave train. Cobble landslides transfer on average 43% more kinetic energy into the wave train than corresponding gravel landslides. Predictive equations for the offshore propagating wave amplitudes, periods, celerities and lengths generated by landslides on planar and divergent convex conical hill slopes are derived, which allow an initial rapid tsunami hazard assessment. C1 [McFall, Brian C.] US Army Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. [McFall, Brian C.; Fritz, Hermann M.] Georgia Inst Technol, Sch Civil & Environm Engn, Atlanta, GA 30332 USA. RP McFall, BC (reprint author), US Army Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.; McFall, BC (reprint author), Georgia Inst Technol, Sch Civil & Environm Engn, Atlanta, GA 30332 USA. EM brian.c.mcfall@usace.army.mil RI Fritz, Hermann/H-5618-2013 OI Fritz, Hermann/0000-0002-6798-5401 FU National Science Foundation (NSF), Division of Civil, Mechanical and Manufacturing Innovation awards [CMMI-0421090, CMMI-0936603, CMMI-0402490, CMMI-0927178]; US Department of Defense through Science, Mathematics and Research for Transformation fellowship FX This work was supported by the National Science Foundation (NSF), Division of Civil, Mechanical and Manufacturing Innovation awards: CMMI-0421090, CMMI-0936603, CMMI-0402490 and CMMI-0927178, and the US Department of Defense through the Science, Mathematics and Research for Transformation fellowship. NR 88 TC 3 Z9 3 U1 2 U2 7 PU ROYAL SOC PI LONDON PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND SN 1364-5021 EI 1471-2946 J9 P ROY SOC A-MATH PHY JI Proc. R. Soc. A-Math. Phys. Eng. Sci. PD APR 1 PY 2016 VL 472 IS 2188 AR 20160052 DI 10.1098/rspa.2016.0052 PG 24 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DO3ZI UT WOS:000377720900019 PM 27274697 ER PT J AU Summers-Stay, D Voss, C Cassidy, T AF Summers-Stay, Douglas Voss, Clare Cassidy, Taylor TI Using a distributional semantic vector space with a knowledge base for reasoning in uncertain conditions SO BIOLOGICALLY INSPIRED COGNITIVE ARCHITECTURES LA English DT Article DE Semantic vector space; Knowledge base; Analogy ID ANALOGY; BRAIN AB The inherent inflexibility and incompleteness of commonsense knowledge bases (KB) has limited their usefulness. We describe a system called Displacer for performing KB queries extended with the analogical capabilities of the word2vec distributional semantic vector space (DSVS). This allows the system to answer queries with information which was not contained in the original KB in any form. By performing analogous queries on semantically related terms and mapping their answers back into the context of the original query using displacement vectors, we are able to give approximate answers to many questions which, if posed to the KB atone, would return no results. We also show how the hand-curated knowledge in a KB can be used to increase the accuracy of a DSVS in solving analogy problems. In these ways, a KB and a DSVS can make up for each other's weaknesses. Published by Elsevier B.V. C1 [Summers-Stay, Douglas; Voss, Clare; Cassidy, Taylor] US Army Res Lab, Adelphi, MD 20783 USA. RP Summers-Stay, D (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM douglas.a.summers-stay.civ@mail.mil NR 20 TC 0 Z9 0 U1 2 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 2212-683X EI 2212-6848 J9 BIOL INSPIR COGN ARC JI Biol. Inspired Cogn. Archit. PD APR PY 2016 VL 16 BP 34 EP 44 DI 10.1016/j.bica.2016.03.002 PG 11 WC Computer Science, Artificial Intelligence; Neurosciences SC Computer Science; Neurosciences & Neurology GA DN1OK UT WOS:000376835100004 ER PT J AU Cheruiyot, AC Auschwitz, JM Lee, PJ Yeda, RA Okello, CO Leed, SE Talwar, M Murthy, T Gaona, HW Hickman, MR Akala, HM Kamau, E Johnson, JD AF Cheruiyot, Agnes C. Auschwitz, Jennifer M. Lee, Patricia J. Yeda, Redemptah A. Okello, Charles O. Leed, Susan E. Talwar, Mayank Murthy, Tushar Gaona, Heather W. Hickman, Mark R. Akala, Hoseah M. Kamau, Edwin Johnson, Jacob D. TI Assessment of the Worldwide Antimalarial Resistance Network Standardized Procedure for In Vitro Malaria Drug Sensitivity Testing Using SYBR Green Assay for Field Samples with Various Initial Parasitemia Levels SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID LINKED-IMMUNOSORBENT-ASSAY; PLASMODIUM-FALCIPARUM; SUSCEPTIBILITY; CAMBODIA; VALIDATION; EFFICACY; VACCINE AB The malaria SYBR green assay, which is used to profile in vitro drug susceptibility of Plasmodium falciparum, is a reliable drug screening and surveillance tool. Malaria field surveillance efforts provide isolates with various low levels of parasitemia. To be advantageous, malaria drug sensitivity assays should perform reproducibly among various starting parasitemia levels rather than at one fixed initial value. We examined the SYBR green assay standardized procedure developed by the Worldwide Antimalarial Resistance Network (WWARN) for its sensitivity and ability to accurately determine the drug concentration that inhibits parasite growth by 50% (IC50) in samples with a range of initial parasitemia levels. The initial sensitivity determination of the WWARN procedure yielded a detection limit of 0.019% parasitemia. P. falciparum laboratory strains and field isolates with various levels of initial parasitemia were then subjected to a range of doses of common antimalarials. The IC(50)s were comparable for laboratory strains with between 0.0375% and 0.6% parasitemia and for field isolates with between 0.075% and 0.6% parasitemia for all drugs tested. Furthermore, assay quality (Z') analysis indicated that the WWARN procedure displays high robustness, allowing for drug testing of malaria field samples within the derived range of initial parasitemia. The use of the WWARN procedure should allow for the inclusion of more malaria field samples in malaria drug sensitivity screens that would have otherwise been excluded due to low initial parasitemia levels. C1 [Cheruiyot, Agnes C.; Yeda, Redemptah A.; Okello, Charles O.; Akala, Hoseah M.; Kamau, Edwin; Johnson, Jacob D.] Kenya Med Res Inst KEMRI Walter Reed Project, US Army Med Res Directorate Kenya USAMRD K, Dept Emerging Infect Dis, Global Emerging Infect Surveillance & Response Sy, Kisumu, Kenya. [Auschwitz, Jennifer M.; Lee, Patricia J.; Leed, Susan E.; Talwar, Mayank; Murthy, Tushar; Gaona, Heather W.; Hickman, Mark R.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. RP Johnson, JD (reprint author), Kenya Med Res Inst KEMRI Walter Reed Project, US Army Med Res Directorate Kenya USAMRD K, Dept Emerging Infect Dis, Global Emerging Infect Surveillance & Response Sy, Kisumu, Kenya. EM jacob.d.johnson.mil@mail.mil FU AFHSC-GEIS [C0651_12_KY] FX AFHSC-GEIS provided funding to Agnes C. Cheruiyot, Redemptah A. Yeda, Charles O. Okello, Hoseah M. Akala, Edwin Kamau, and Jacob D. Johnson under grant number C0651_12_KY. NR 27 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD APR PY 2016 VL 60 IS 4 BP 2417 EP 2424 DI 10.1128/AAC.00527-15 PG 8 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA DM6XL UT WOS:000376496100054 PM 26856829 ER PT J AU Tenan, MS AF Tenan, Matthew S. TI Quantifying Emergency Department Visits From Sport and Recreation: Focus on the Lower Extremity and Knee, 1997-2009 SO JOURNAL OF ATHLETIC TRAINING LA English DT Article DE female athletes; general sports trauma; epidemiology; injury surveillance ID MEDICAL-CARE SURVEY; GENDER-DIFFERENCES; UNITED-STATES; INJURIES; EPIDEMIOLOGY; BASKETBALL; FEMALE AB Context: Few authors have reported nationally representative data on the number of sport and recreation (SR) injuries resulting in emergency department (ED) visitation. The existing studies have only provided 1 or 2 years of data and are not longitudinal in nature. Objective: To use a novel algorithmic approach to determine if ED visitation is due to SR, resulting in a substantially larger longitudinal dataset. Design: Descriptive epidemiology study. Setting: Hospital. Patients or Other Participants: The National Hospital Ambulatory Medical Care Survey, a stratified random-sample survey of US hospital EDs was combined for years 1997-2009. There were 15 699 unweighted patient visits determined to be from SR. Main Outcome Measure(s): A custom algorithm classified SR visits based on the International Classification of Diseases, Ninth Revision, Clinical Modification E-code and pattern recognition of narrative text. Sport and recreation visits were assessed by age and categorized according to broad injury classifications. Additional quantification was performed on SR visits for lower extremity and knee-specific injuries. Sample weights were applied to provide national annual estimates. Results: Annually, 4 243 000 ED visits resulted from SR. The largest classification of injury from SR was sprains and strains (896 000/y). Males had substantially more SR-related ED visits than females (2 929 000/y versus 1 314 000/y). For patients 10-49 years old, 1 093 000 lower extremity and 169 000 knee-specific injury visits annually were from SR. For both injury types, males had a higher rate of ED visitation; however, females had 25% and 39% greater odds of visitation for lower extremity and knee-specific injury, respectively. Conclusions: The burden on the health system of ED visits from SR was substantial. Males presented in the ED at a higher rate for SR injury, though females had a higher proportion of lower extremity and knee-specific injury ED visitations from SR. This longitudinal analysis of population-level data provides the information to target research on specific subpopulations to mitigate SR injury. C1 [Tenan, Matthew S.] US Army Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Tenan, MS (reprint author), US Army Res Lab, Human Res & Engn Directorate, RDRL HRS B, Aberdeen Proving Ground, MD 21005 USA. EM matthew.s.tenan.civ@mail.mil NR 22 TC 0 Z9 0 U1 1 U2 3 PU NATL ATHLETIC TRAINERS ASSOC INC PI DALLAS PA 2952 STEMMONS FREEWAY, DALLAS, TX 75247 USA SN 1062-6050 EI 1938-162X J9 J ATHL TRAINING JI J. Athl. Train. PD APR PY 2016 VL 51 IS 4 BP 309 EP 316 DI 10.4085/1062-6050-51.4.12 PG 8 WC Sport Sciences SC Sport Sciences GA DM6DQ UT WOS:000376441000005 PM 27075528 ER PT J AU Kenefick, RW Cheuvront, SN AF Kenefick, Robert W. Cheuvront, Samuel N. TI Physiological adjustments to hypohydration: Impact on thermoregulation SO AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL LA English DT Review DE Hypohydration; Dehydration; Fluid deficit; Thermoregulation ID EXERCISE-HEAT STRESS; BODY-TEMPERATURE; BLOOD-VOLUME; AIR-FLOW; CUTANEOUS VASODILATION; DEHYDRATION ASSESSMENT; CARDIOVASCULAR DRIFT; EVAPORATIVE RATES; HYDRATION LEVEL; ELECTRIC FANS AB Sufficient body water is required to sustain thermoregulatory function, thus losses in total body water (TBW) can challenge the thermoregulatory system. A TBW deficit >= 2% body mass (hypohydration) is recognized as the threshold when thermoregulatory function becomes measurably altered. Hypohydration may occur from voluntary fluid restriction, insufficient fluid availability, or thermoregulatory sweating. The secretion and evaporation of sweat important avenues of body heat loss, and if the water lost is not replaced, hypohydration will decrease plasma volume and increase plasma osmotic pressure (hyperosmotic hypovolemia). Both osmotic and/or volume stressors delay the onset and/or reduce the sensitivity of sweating and blood flow responses. The magnitude of hypohydration, environmental heat stress, the population and circumstances of interest will determine the degree, significance and outcome of these thermoregulatory alterations and their contribution to physiological stress. Published by Elsevier B.V. C1 [Kenefick, Robert W.; Cheuvront, Samuel N.] US Army Res Inst Environm Med, Natick, MA 01760 USA. RP Kenefick, RW (reprint author), US Army Res Inst Environm Med, Thermal & Mt Med Div, Kansas St, Natick, MA 01760 USA. EM Robert.W.Kenefick.civ@mail.mil NR 73 TC 1 Z9 1 U1 5 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1566-0702 EI 1872-7484 J9 AUTON NEUROSCI-BASIC JI Auton. Neurosci-Basic Clin. PD APR PY 2016 VL 196 SI SI BP 47 EP 51 DI 10.1016/j.autneu.2016.02.003 PG 5 WC Neurosciences SC Neurosciences & Neurology GA DM0QJ UT WOS:000376050600006 PM 26944095 ER PT J AU Castellani, JW Young, AJ AF Castellani, John W. Young, Andrew J. TI Human physiological responses to cold exposure: Acute responses and acclimatization to prolonged exposure SO AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL LA English DT Review DE Habituation, hypothermia; Insulative acclimatization; Shivering; Temperature regulation; Vasoconstriction ID AGED HUMAN SKIN; BROWN ADIPOSE-TISSUE; INDUCED CUTANEOUS VASOCONSTRICTION; HUMAN THERMOREGULATORY RESPONSES; BASAL METABOLIC-RATES; KOREAN WOMEN DIVERS; WATER IMMERSION; BLOOD-FLOW; PHYSICAL-FITNESS; BODY-TEMPERATURE AB Cold exposure in humans causes specific acute and chronic physiological responses. This paper will review both the acute and long-term physiological responses and external factors that impact these physiological responses. Acute physiological responses to cold exposure include cutaneous vasoconstriction and shivering thermogenesis which, respectively, decrease heat loss and increase metabolic heat production. Vasoconstriction is elicited through reflex and local cooling. In combination, vasoconstriction and shivering operate to maintain thermal balance when the body is losing heat. Factors (anthropometry, sex, race, fitness, thermoregulatory fatigue) that influence the acute physiological responses to cold exposure are also reviewed. The physiological responses to chronic cold exposure, also known as cold acclimation/acclimatization, are also presented. Three primary patterns of cold acclimatization have been observed, a) habituation, b) metabolic adjustment, and c) insulative adjustment. Habituation is characterized by physiological adjustments in which the response is attenuated compared to an unacclimatized state. Metabolic acclimatization is characterized by an increased thermogenesis, whereas insulative acclimatization is characterized by enhancing the mechanisms that conserve body heat. The pattern of acclimatization is dependent on changes in skin and core temperature and the exposure duration. Published by Elsevier B.V. C1 [Castellani, John W.; Young, Andrew J.] US Army Res Inst Environm Med, Natick, MA 01760 USA. RP Castellani, JW (reprint author), US Army Res Inst Environm Med, Thermal & Mt Med Div, 10 Gen Greene Ave, Natick, MA 01760 USA. EM john.w.castellani.civ@mail.mil NR 131 TC 2 Z9 2 U1 26 U2 38 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1566-0702 EI 1872-7484 J9 AUTON NEUROSCI-BASIC JI Auton. Neurosci-Basic Clin. PD APR PY 2016 VL 196 SI SI BP 63 EP 74 DI 10.1016/j.autneu.2016.02.009 PG 12 WC Neurosciences SC Neurosciences & Neurology GA DM0QJ UT WOS:000376050600008 PM 26924539 ER PT J AU Pichugin, A Steers, N De la Vega, P Zarling, S Chalom, I Krzych, U AF Pichugin, Alexander Steers, Nick De la Vega, Patricia Zarling, Stasya Chalom, Isaac Krzych, Urszula TI TAP-mediated processing of exoerythrocytic antigens is essential for protection induced with radiation-attenuated Plasmodium sporozoites SO EUROPEAN JOURNAL OF IMMUNOLOGY LA English DT Article DE Antigen presenting cells; CD8(+) T cells; Liver; Plasmodium; Transporter associated with antigen processing (TAP) ID CD8(+) T-CELLS; CLASS-I MOLECULES; MALARIA LIVER STAGES; CIRCUMSPOROZOITE PROTEIN; CROSS-PRESENTATION; INFECTED HEPATOCYTES; DENDRITIC CELLS; IRRADIATED SPOROZOITES; BERGHEI SPOROZOITES; PROTRACTED PROTECTION AB MHC class I dependent CD8(+) T cells are essential for protection induced by radiationattenuated Plasmodium sporozoites (RAS) inmurine malaria models. Apart from the mechanism of activation of CD8(+) T cells specific for the circumsporozoite protein, the major sporozoite antigen (Ag), CD8(+) T cells specific for other exoerythrocytic Ags that have been shown to mediate protection have not been thoroughly investigated. Specifically, mechanisms of processing and presentation of exoerythrocytic Ags, which includes liver stage (LS) Ags, remain poorly understood. We hypothesize that as exogenous proteins, LS Ags are processed by mechanisms involving either the TAP-dependent phagosomal-to- cytosol or TAP-independent vacuolar pathway of cross-presentation. We used TAP-deficient mice to investigate whether LS Ag mediated induction of naive CD8(+) T cells and their recall during sporozoite challenge occur by the TAP-dependent or TAP-independent pathways. On the basis of functional attributes, CD8(+) T cells were activated via the TAP-independent pathway during immunizations with Plasmodium berghei RAS; however, IFN-gamma(+) CD8(+) T cells previously induced by P. berghei RAS in TAP-deficient mice failed to be recalled against sporozoite challenge and the mice became parasitemic. On the basis of these observations, we propose that TAP-associated Ag processing is indispensable for sterile protection induced with P. berghei RAS. C1 [Pichugin, Alexander; Steers, Nick; De la Vega, Patricia; Zarling, Stasya; Chalom, Isaac; Krzych, Urszula] Walter Reed Army Inst Res, Malaria Vaccine Branch, Dept Cellular Immunol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. RP Krzych, U (reprint author), Walter Reed Army Inst Res, Malaria Vaccine Branch, Dept Cellular Immunol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Urszula.Krzych1.civ@mail.mil OI Pichugin, Alexander/0000-0002-2577-7284 FU NIH [AI46438]; US Army Materiel Command FX The authors would like to express their thanks to the members of the Krzych lab for assistance with the experiments and helpful discussions. We are grateful to Dr. Sofia Casares for critical reading of the manuscript. This research was supported in part by a NIH grant AI46438 (UK) and the US Army Materiel Command. The views of the authors do not purport to reflect the position of the Department of the Army or the Department of Defense. NR 65 TC 2 Z9 2 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0014-2980 EI 1521-4141 J9 EUR J IMMUNOL JI Eur. J. Immunol. PD APR PY 2016 VL 46 IS 4 BP 885 EP 896 DI 10.1002/eji.201545748 PG 12 WC Immunology SC Immunology GA DJ9SH UT WOS:000374552700011 PM 26703789 ER PT J AU Holmquist, TJ Bradley, J Dwivedi, A Casem, D AF Holmquist, T. J. Bradley, J. Dwivedi, A. Casem, D. TI The response of polymethyl methacrylate (PMMA) subjected to large strains, high strain rates, high pressures, a range in temperatures, and variations in the intermediate principal stress SO EUROPEAN PHYSICAL JOURNAL-SPECIAL TOPICS LA English DT Article ID GLASSY-POLYMERS; BEHAVIOR; DEFORMATION; FRACTURE AB This article presents the response of polymethyl methacrylate (PMMA) subjected to large strains, high strain rates, high pressures, a range in temperatures, and variations in the intermediate principal stress. Laboratory data from the literature, and new test data provided here, are used in the evaluation. The new data include uniaxial stress compression tests (at various strain rates and temperatures) and uniaxial stress tension tests (at low strain rates and ambient temperatures). The compression tests include experiments at I double dagger epsilon = 13,000 s(-1), significantly extending the range of known strain rate data. The observed behavior of PMMA includes the following: it is brittle in compression at high rates, and brittle in tension at all rates; strength is dependent on the pressure, strain, strain rate, temperature, and the intermediate principal stress; the shear modulus increases as the pressure increases; and it is highly compressible. Also presented are novel, high velocity impact tests (using high-speed imaging) that provide insight into the initiation and evolution of damage. Lastly, computational constitutive models for pressure, strength, and failure are presented that provide responses that are in good agreement with the laboratory data. The models are used to compute several ballistic impact events for which experimental data are available. C1 [Holmquist, T. J.] Southwest Res Inst, Minneapolis, MN 55416 USA. [Bradley, J.; Dwivedi, A.; Casem, D.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Holmquist, TJ (reprint author), Southwest Res Inst, Minneapolis, MN 55416 USA. EM timothy.holmquist@swri.org FU [W911QX-10-C-0040] FX This work was performed for the U.S. Army Research Laboratory (ARL), Aberdeen Proving Ground, MD under contract No. W911QX-10-C-0040. The authors would like to thank D. Kleponis, E. Horwath, P. Patel, B. Scott and B. Vonk for their helpful discussions and support throughout this effort. NR 23 TC 0 Z9 0 U1 5 U2 5 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1951-6355 EI 1951-6401 J9 EUR PHYS J-SPEC TOP JI Eur. Phys. J.-Spec. Top. PD APR PY 2016 VL 225 IS 2 BP 343 EP 354 DI 10.1140/epjst/e2016-02636-5 PG 12 WC Physics, Multidisciplinary SC Physics GA DK0DX UT WOS:000374583900011 ER PT J AU Fansiri, T Pongsiri, A Klungthong, C Ponlawat, A Thaisomboonsuk, B Jarman, RG Scott, TW Lambrechts, L AF Fansiri, Thanyalak Pongsiri, Arissara Klungthong, Chonticha Ponlawat, Alongkot Thaisomboonsuk, Butsaya Jarman, Richard G. Scott, Thomas W. Lambrechts, Louis TI No evidence for local adaptation of dengue viruses to mosquito vector populations in Thailand SO EVOLUTIONARY APPLICATIONS LA English DT Article DE Aedes aegypti; dengue virus; genotype x genotype interactions; local adaptation; population structure ID AEDES-AEGYPTI POPULATIONS; KAMPHAENG-PHET; ORAL-SUSCEPTIBILITY; GLOBAL DISTRIBUTION; CLADE REPLACEMENT; GENETIC-STRUCTURE; TRANSMISSION; INFECTION; STRAINS; MEXICO AB Despite their epidemiological importance, the evolutionary forces that shape the spatial structure of dengue virus genetic diversity are not fully understood. Fine-scale genetic structure of mosquito vector populations and evidence for genotype x genotype interactions between dengue viruses and their mosquito vectors are consistent with the hypothesis that the geographical distribution of dengue virus genetic diversity may reflect viral adaptation to local mosquito populations. To test this hypothesis, we measured vector competence in all sympatric and allopatric combinations of 14 low-passage dengue virus isolates and two wild-type populations of Aedes aegypti mosquitoes sampled in Bangkok and Kamphaeng Phet, two sites located about 300km apart in Thailand. Despite significant genotype x genotype interactions, we found no evidence for superior vector competence in sympatric versus allopatric vector-virus combinations. Viral phylogenetic analysis revealed no geographical clustering of the 14 isolates, suggesting that high levels of viral migration (gene flow) in Thailand may counteract spatially heterogeneous natural selection. We conclude that it is unlikely that vector-mediated selection is a major driver of dengue virus adaptive evolution at the regional scale that we examined. Dengue virus local adaptation to mosquito vector populations could happen, however, in places or times that we did not test, or at a different geographical scale. C1 [Fansiri, Thanyalak; Pongsiri, Arissara; Ponlawat, Alongkot] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Klungthong, Chonticha; Thaisomboonsuk, Butsaya; Jarman, Richard G.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Scott, Thomas W.] Univ Calif Davis, Dept Entomol & Nematol, Davis, CA 95616 USA. [Scott, Thomas W.] NIH, Fogarty Int Ctr, Bldg 10, Bethesda, MD 20892 USA. [Lambrechts, Louis] Inst Pasteur, Dept Genomes & Genet, Insect Virus Interact Grp, 28 Rue Docteur Roux, F-75724 Paris 15, France. [Lambrechts, Louis] Ctr Natl Rech Sci, Unite Rech Associee, Paris, France. [Jarman, Richard G.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD USA. RP Lambrechts, L (reprint author), Inst Pasteur, Dept Genomes & Genet, Insect Virus Interact Grp, 28 Rue Docteur Roux, F-75724 Paris 15, France. EM louis.lambrechts@pasteur.fr RI Lambrechts, Louis/A-2057-2010 OI Lambrechts, Louis/0000-0001-5958-2138 FU United States National Institutes of Health [R01-GM083224]; United States Military Infectious Diseases Research Program; French Agence Nationale de la Recherche [ANR-09-RPDOC-007-01]; French Government's Investissement d'Avenir program, Laboratoire d'Excellence Integrative Biology of Emerging Infectious Diseases [ANR-10-LABX-62-IBEID]; City of Paris Emergence(s) program in Biomedical Research; Research and Policy for Infectious Disease Dynamics program of the Science and Technology Directorate, Department of Homeland Security; Fogarty International Center, United States National Institutes of Health; United States National Institutes of Health and Human Services [P01-AI098670] FX We acknowledge the invaluable contributions of the clinical, laboratory, and entomological personnel of AFRIMS and Kamphaeng Phet AFRIMS Virology Research Unit (KAVRU). We are grateful to Robert Gibbons, Stefan Fernandez, Timothy Endy, Anthony Schuster, and three anonymous reviewers for their insights. The opinions or assertions contained herein are the private views of the authors and are not to be construed as reflecting the official views of the United States Army, Royal Thai Army, or the United States Department of Defense. This study was primarily supported by grant R01-GM083224 from the United States National Institutes of Health and by the United States Military Infectious Diseases Research Program. L.L. received funding from the French Agence Nationale de la Recherche (grant ANR-09-RPDOC-007-01), the French Government's Investissement d'Avenir program, Laboratoire d'Excellence Integrative Biology of Emerging Infectious Diseases (grant ANR-10-LABX-62-IBEID), and the City of Paris Emergence(s) program in Biomedical Research. T.W.S. received support from the Research and Policy for Infectious Disease Dynamics program of the Science and Technology Directorate, Department of Homeland Security, and Fogarty International Center, United States National Institutes of Health. L.L. and T.W.S. received support from the United States National Institutes of Health and Human Services (grant P01-AI098670). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 47 TC 2 Z9 2 U1 1 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1752-4571 J9 EVOL APPL JI Evol. Appl. PD APR PY 2016 VL 9 IS 4 BP 608 EP 618 DI 10.1111/eva.12360 PG 11 WC Evolutionary Biology SC Evolutionary Biology GA DJ9SM UT WOS:000374553200007 PM 27099625 ER PT J AU Ernst, M Habtour, E Dasgupta, A AF Ernst, Matthew Habtour, Ed Dasgupta, Abhijit TI Examining Steinberg's Octave Rule Applicability for Electronic Systems Exposed to Multiaxial Vibration SO IEEE TRANSACTIONS ON COMPONENTS PACKAGING AND MANUFACTURING TECHNOLOGY LA English DT Article DE Amplification; fatigue; multiaxial vibration; nonlinear; random; reliability ID PREDICTION; FATIGUE AB This paper explores the role of nonlinear dynamical phenomena in calculating the stress amplitude in large electronic components exposed to biaxial vibration loading. Nonlinear analytical studies are presented where a component exposed to combined axial and transverse vibratory base excitation is idealized using a nonlinear structural beam element with a tip mass. Harmonic and random base vibration excitation studies are conducted. The results provided in this paper confirm that Steinberg's Octave rule may not be applicable for electronic components exposed to high amplitude multiaxial vibrations. In fact, components exposed to biaxial vibration are highly dependent on the phase angle between the orthogonal axes and the frequency ratio between the axial and transverse excitation frequencies. At critical frequency ratios, undesirable constructive and destructive stress amplification phenomena may appear if the system is exposed to a harsh multidirectional vibration environment. C1 [Ernst, Matthew] US Air Force, Lifecycle Management Ctr, Wright Patterson AFB, OH 45433 USA. [Habtour, Ed] US Army, Res Lab, Adelphi, MD 21005 USA. [Dasgupta, Abhijit] Univ Maryland, Dept Mech Engn, Ctr Adv Life Cycle Engn, College Pk, MD 20742 USA. RP Ernst, M (reprint author), US Air Force, Lifecycle Management Ctr, Wright Patterson AFB, OH 45433 USA.; Habtour, E (reprint author), US Army, Res Lab, Adelphi, MD 21005 USA.; Dasgupta, A (reprint author), Univ Maryland, Dept Mech Engn, Ctr Adv Life Cycle Engn, College Pk, MD 20742 USA. EM ernstm@gmail.com; ed.m.habtour.civ@mail.mil; dasgupta@umd.edu FU CALCE Consortium; TEAM Inc.; Data Physics Inc. FX This work was supported in part by CALCE Consortium, in part by TEAM Inc., and in part by Data Physics Inc. NR 21 TC 0 Z9 0 U1 3 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 2156-3950 EI 2156-3985 J9 IEEE T COMP PACK MAN JI IEEE Trans. Compon. Pack. Manuf. Technol. PD APR PY 2016 VL 6 IS 4 BP 561 EP 568 DI 10.1109/TCPMT.2016.2519447 PG 8 WC Engineering, Manufacturing; Engineering, Electrical & Electronic; Materials Science, Multidisciplinary SC Engineering; Materials Science GA DJ9RV UT WOS:000374551500008 ER PT J AU Perotti, LP Cummings, LD Mercado, J AF Perotti, Laurence P. Cummings, Latiba D. Mercado, Janyna TI Behavioral Treatment of Pseudobulbar Affect: A Case Report SO PERSPECTIVES IN PSYCHIATRIC CARE LA English DT Article ID MULTIPLE-SCLEROSIS; DEXTROMETHORPHAN/QUINIDINE; MANAGEMENT AB PURPOSE: To determine if it is possible to successfully treat pseudobulbar affect (PBA) using a behavioral approach. DESIGN AND METHODS: Two experiments were conducted, each a double reversal design with the same single subject in both. The first experiment tested the hypothesis that the rate of PBA could be controlled by manipulation of its consequences. The second experiment tested the hypothesis that use of a self-control procedure would control the rate of PBA. FINDINGS: Rate of PBA could not be controlled by consequence manipulation, but rate of PBA could be controlled through use of a self-control procedure. PRACTICE IMPLICATIONS: Pending confirmatory research, behavioral interventions utilizing self-control procedures should be considered in patients with PBA. C1 [Perotti, Laurence P.] Brooke Army Med Ctr, Multidisciplinary Clin, Dept Behav Med, San Antonio, TX USA. [Cummings, Latiba D.] Brooke Army Med Ctr, Dept Orthoped, Brain Injury Rehabil Serv, San Antonio, TX USA. [Mercado, Janyna] Brooke Army Med Ctr, Dept Behav Med, Neuropsychol Serv, San Antonio, TX USA. RP Perotti, LP (reprint author), Brooke Army Med Ctr, Multidisciplinary Clin, Dept Behav Med, San Antonio, TX USA. EM Laurence.p.perotti.civ@mail.mil NR 20 TC 1 Z9 1 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0031-5990 EI 1744-6163 J9 PERSPECT PSYCHIATR C JI Perspect. Psychiatr. Care PD APR PY 2016 VL 52 IS 2 BP 82 EP 87 DI 10.1111/ppc.12159 PG 6 WC Nursing; Psychiatry SC Nursing; Psychiatry GA DK1GW UT WOS:000374661500002 PM 27091117 ER PT J AU Chung, RB Rodak, LE Enck, RW Sampath, AV Wraback, M Reed, ML AF Chung, Roy B. Rodak, Lee E. Enck, Ryan W. Sampath, Anand V. Wraback, Michael Reed, Meredith L. TI Growth and impurity characterization of AlN on (0001) sapphire grown by spatially pulsed MOCVD SO PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE LA English DT Article; Proceedings Paper CT Compound Semiconductor Week (CSW) CY JUN 28-JUL 02, 2015 CL Santa Barbara, CA DE AlN; impurity; MOCVD; pre-reaction; spatially pulsed growth ID CHEMICAL-VAPOR-DEPOSITION; MOVPE AB The reduction of undesirable gas phase reaction between trimethylaluminum and NH3 was achieved by spatially separating the precursors using N-2 purge line during AlN growth by metal organic chemical vapor deposition (MOCVD). Under this condition, it was shown that the growth pressure has a strong impact on the surface morphology independent of pre-reaction. For 0.8-mu m-thick AlN grown on (0001) sapphire substrates, increasing pressure from 200 to 500Torr drastically increased a root-mean-squared surface (r.m.s.) roughness from 0.48 to 33nm. This morphological change was previously attributed to the pre-reaction. Less pre-reaction also allowed us to investigate the pressure dependence of impurity (carbon and oxygen) incorporation in AlN as the growth rate was no longer affected by the pressure. Unlike GaN, the carbon level almost doubled with increasing pressure from 200 to 500Torr. By optimizing the surface morphology (r.m.s. roughness from 33 to 0.62nm) at 500Torr, the carbon concentration in AlN decreased from 5x10(18) to 7x10(17)cm(-3). Although there was no improvement in the structural quality, this uniquely designed MOCVD could further improve the material quality of AlN by reducing the impurity level. (C) 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim C1 [Chung, Roy B.; Rodak, Lee E.; Enck, Ryan W.; Sampath, Anand V.; Wraback, Michael; Reed, Meredith L.] US Army, Res Lab, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RP Chung, RB (reprint author), US Army, Res Lab, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM roy.chung2.ctr@mail.mil NR 18 TC 0 Z9 0 U1 9 U2 10 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 1862-6300 EI 1862-6319 J9 PHYS STATUS SOLIDI A JI Phys. Status Solidi A-Appl. Mat. PD APR PY 2016 VL 213 IS 4 BP 851 EP 855 DI 10.1002/pssa.201532571 PG 5 WC Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Materials Science; Physics GA DJ9VC UT WOS:000374560100002 ER PT J AU Bjerkvig, CK Strandenes, G Eliassen, HS Spinella, PC Fosse, TK Cap, AP Ward, KR AF Bjerkvig, Christopher K. Strandenes, Geir Eliassen, Hakon S. Spinella, Philip C. Fosse, Theodor K. Cap, Andrew P. Ward, Kevin R. TI "Blood failure" time to view blood as an organ: how oxygen debt contributes to blood failure and its implications for remote damage control resuscitation SO TRANSFUSION LA English DT Review ID RANDOMIZED CONTROLLED-TRIAL; WHOLE-BLOOD; HEMORRHAGIC-SHOCK; TRAUMA PATIENTS; TRANSFUSION; CELLS; MORTALITY; LACTATE; COAGULOPATHY; PREDICTORS AB Hemorrhagic shock is both a local and systemic disorder. In the context of systemic effects, blood loss may lead to levels of reduced oxygen delivery (DO2) sufficient to cause tissue ischemia. Similar to other physiologic debts such as sleep, it is not possible to incur a significant oxygen debt and suffer no consequences for lack of timely repayment. While the linkage between oxygen debt and traditional organ failure (renal, hepatic, lung, and circulation) has been long recognized, we should consider failure in two additional linked and very dynamic organ systems, the endothelium and blood. These systems are very sensitive to oxygen debt and at risk for failing, having further implications on all other organ systems. The degree of damage to the endothelium is largely modulated by the degree of oxygen debt. Thus hypoperfusion is believed to begin a cascade of events leading to acute traumatic coagulopathy (ATC). This combination of oxygen debt driven endothelial damage and ATC might be considered collectively as blood failure due to the highly connected networks between these drivers. This article presents the implications of oxygen debt for remote damage control resuscitation strategies, such as permissive hypotension and hemostatic resuscitation. We review the impact of whole blood resuscitation and red blood cell efficacy in mitigation of oxygen debt. At last, this article recognizes the need for simple and durable, lightweight equipment that can detect the adequacy of tissue DO2 and thus patient needs for resuscitative care. Point-of-care lactate measuring may be a predictive tool for identifying high-risk trauma patients and occult shock because it provides information beyond that of vital signs and mechanism of injury as it may help predict the level of oxygen debt accumulation and need for resuscitation. Serial measurements may also be valuable as a tool in guiding resuscitative efforts. C1 [Bjerkvig, Christopher K.; Strandenes, Geir; Fosse, Theodor K.] Haukeland Hosp, Norwegian Naval Special Operat Command, N-5021 Bergen, Norway. [Bjerkvig, Christopher K.; Fosse, Theodor K.] Haukeland Hosp, Dept Anesthesia & Intens Care, N-5021 Bergen, Norway. [Strandenes, Geir; Eliassen, Hakon S.] Haukeland Hosp, Dept Immunol & Transfus Med, N-5021 Bergen, Norway. [Spinella, Philip C.] Washington Univ, Div Pediat Crit Care, Dept Pediat, St Louis, MO USA. [Spinella, Philip C.] US Army, Coagulat & Blood Res, Inst Surg Res, Jbsa Ft Sam Houston, TX USA. [Ward, Kevin R.] Univ Michigan, Michigan Ctr Integrat Res Crit Care, Dept Emergency Med, Ann Arbor, MI 48109 USA. [Cap, Andrew P.] US Army, Blood Res Program, Inst Surg Res, Ft Sam Houston, TX USA. RP Ward, KR (reprint author), Michigan Ctr Integrat Res Crit Care, NCRC Bldg 10 Off A103,2800 Plymouth Rd, Ann Arbor, MI 48109 USA. EM keward@umich.edu NR 43 TC 2 Z9 2 U1 1 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 EI 1537-2995 J9 TRANSFUSION JI Transfusion PD APR PY 2016 VL 56 SU 2 SI SI BP S182 EP S189 DI 10.1111/trf.13500 PG 8 WC Hematology SC Hematology GA DK1ZK UT WOS:000374714200011 PM 27100755 ER PT J AU Doughty, H Thompson, P Cap, AP Spinella, PC Glassberg, E Eliassen, HS De Pasquale, M Strandenes, G AF Doughty, Heidi Thompson, Patrick Cap, Andrew P. Spinella, Philip C. Glassberg, Elon Eliassen, Hakon Skogrand De Pasquale, Marc Strandenes, Geir TI A proposed field emergency donor panel questionnaire and triage tool SO TRANSFUSION LA English DT Article ID WHOLE-BLOOD; TRANSFUSION; MANAGEMENT; GUIDELINE AB BACKGROUND: The provision of transfusion support to isolated military or civilian projects may require the use of an emergency donor panel (EDP) for immediate warm fresh whole blood (WFWB). The aim of this short discussion article is to raise and resolve some of the practical aspects for the nonspecialist faced with the emergency collection of WFWB whole blood in the austere medical environment (AME). METHODS AND RESULTS: A proposed field EDP questionnaire and triage tool (QTT) is presented. It is designed for the hostile, remote, or austere environment that falls outside normal regulated supply of cold-stored blood products or removed from trained blood collection personnel, where collection may fall to an isolated medical provider. The tool has been drafted based on review of existing guidelines and consultation with practitioners. It serves as a point of reference for local guidelines and has yet to be validated. CONCLUSIONS: The use of the EDP is associated with risk; however, it remains the simplest method of providing rapid transfusion support. The best way to manage the risk is to brief and prescreen blood donors before deployment. An abbreviated donor QTT can be an aide to decision making at the time of donation. The tool should be tailored to requirements and underpinned by policy and training. C1 [Doughty, Heidi] NHS Blood & Transplant, Birmingham B15 2SG, W Midlands, England. [Doughty, Heidi] Queen Elizabeth Hosp, RCDM, Ctr Def Pathol, Birmingham B15 2TH, W Midlands, England. [Thompson, Patrick] UK Paramed, THOR Network, Monmouth, Ireland. [Cap, Andrew P.] JBSA FT, US Army Inst Surg Res, Sam Houston, TX USA. [Glassberg, Elon] Israel Def Forces Med Corps, Ramat Gan, Israel. [Eliassen, Hakon Skogrand] Washington Univ, Dept Pediat, Div Crit Care, St Louis, MO 63130 USA. [Eliassen, Hakon Skogrand; Strandenes, Geir] Haukeland Hosp, Norwegian Naval Special Operat Commando, N-5021 Bergen, Norway. [Eliassen, Hakon Skogrand; Strandenes, Geir] Haukeland Hosp, Dept Immunol & Transfus Med, N-5021 Bergen, Norway. [De Pasquale, Marc] Independent Paramed US, THOR Network, Portland, OR USA. RP Doughty, H (reprint author), NHS Blood & Transplant, Birmingham B15 2SG, W Midlands, England. EM heidi.doughty@nhsbt.nhs.uk NR 21 TC 0 Z9 0 U1 3 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 EI 1537-2995 J9 TRANSFUSION JI Transfusion PD APR PY 2016 VL 56 SU 2 SI SI BP S119 EP S127 DI 10.1111/trf.13487 PG 9 WC Hematology SC Hematology GA DK1ZK UT WOS:000374714200004 PM 27100748 ER PT J AU Pusateri, AE Given, MB Schreiber, MA Spinella, PC Pati, S Kozar, RA Khan, A Dacorta, JA Kupferer, KR Prat, N Pidcoke, HF Macdonald, VW Malloy, WW Sailliol, A Cap, AP AF Pusateri, Anthony E. Given, Michael B. Schreiber, Martin A. Spinella, Philip C. Pati, Shibani Kozar, Rosemary A. Khan, Abdul Dacorta, Joseph A. Kupferer, Kevin R. Prat, Nicolas Pidcoke, Heather F. Macdonald, Victor W. Malloy, Wilbur W. Sailliol, Anne Cap, Andrew P. TI Dried plasma: state of the science and recent developments SO TRANSFUSION LA English DT Review ID FRESH-FROZEN PLASMA; RED-BLOOD-CELLS; TRAUMA-ASSOCIATED COAGULOPATHY; DAMAGE CONTROL RESUSCITATION; HEMORRHAGIC-SHOCK; LYOPHILIZED PLASMA; ENDOTHELIAL GLYCOCALYX; VASCULAR-PERMEABILITY; MASSIVE TRANSFUSION; BRAIN-INJURY AB The early transfusion of plasma is important to ensure optimal survival of patients with traumatic hemorrhage. In military and remote or austere civilian settings, it may be impossible to move patients to hospital facilities within the first few hours of injury. A dried plasma product with reduced logistical requirements is needed to enable plasma transfusion where medically needed, instead of only where freezers and other equipment are available. First developed in the 1930s, pooled lyophilized plasma was widely used by British and American forces in WWII and the Korean War. Historical dried plasma products solved the logistical problem but were abandoned because of disease transmission. Modern methods to improve blood safety have made it possible to produce safe and effective dried plasma. Dried plasma products are available in France, Germany, South Africa, and a limited number of other countries. However, no product is available in the US. Promising products are in development that employ different methods of drying, pathogen reduction, pooling, packaging, and other approaches. Although challenges exist, the in vitro and in vivo data suggest that these products have great potential to be safe and effective. The history, state of the science, and recent developments in dried plasma are reviewed. C1 [Pusateri, Anthony E.] US Army, Med Res & Mat Command, 504 Scott St,Bldg 722, Ft Detrick, MD 21702 USA. [Given, Michael B.] Off Naval Res, Arlington, VA 22217 USA. [Schreiber, Martin A.] Oregon Hlth & Sci Univ, Portland, OR 97201 USA. [Spinella, Philip C.] Washington Univ, St Louis, MO 63130 USA. [Pati, Shibani] Blood Syst Res Inst, San Francisco, CA USA. [Kozar, Rosemary A.] Univ Maryland, Sch Med, Baltimore, MD 21201 USA. [Khan, Abdul] Velico Med Inc, Beverly, MA USA. [Dacorta, Joseph A.] Entegrion Inc, Res Triangle Pk, NC USA. [Kupferer, Kevin R.] Air Force Med Support Agcy, Falls Church, VA USA. [Prat, Nicolas] French Armed Forces Inst Biomed Res IRBA Bretigny, Marseille, France. [Pidcoke, Heather F.; Cap, Andrew P.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Macdonald, Victor W.] US Army, Med Res & Mat Command, Med Mat Dev Act, 504 Scott St,Bldg 722, Ft Detrick, MD 21702 USA. [Malloy, Wilbur W.] US Army, Med Res & Mat Command, Congressionally Directed Med Res Programs, 504 Scott St,Bldg 722, Ft Detrick, MD 21702 USA. [Sailliol, Anne] Ctr Transfus Sanguine Armees, Clamart, France. RP Pusateri, AE (reprint author), US Army, Med Res & Mat Command, Combat Casualty Care Res Program, 504 Scott St,Bldg 722, Ft Detrick, MD 21702 USA. EM anthony.e.pusateri.civ@mail.mil RI PRAT, Nicolas/R-4213-2016 NR 68 TC 2 Z9 2 U1 2 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 EI 1537-2995 J9 TRANSFUSION JI Transfusion PD APR PY 2016 VL 56 SU 2 SI SI BP S128 EP S139 DI 10.1111/trf.13580 PG 12 WC Hematology SC Hematology GA DK1ZK UT WOS:000374714200005 PM 27100749 ER PT J AU Spinella, PC Pidcoke, HF Strandenes, G Hervig, T Fisher, A Jenkins, D Yazer, M Stubbs, J Murdock, A Sailliol, A Ness, PM Cap, AP AF Spinella, Philip C. Pidcoke, Heather F. Strandenes, Geir Hervig, Tor Fisher, Andrew Jenkins, Donald Yazer, Mark Stubbs, James Murdock, Alan Sailliol, Anne Ness, Paul M. Cap, Andrew P. TI Whole blood for hemostatic resuscitation of major bleeding SO TRANSFUSION LA English DT Review ID DAMAGE CONTROL RESUSCITATION; VERSUS-HOST-DISEASE; FRESH-FROZEN PLASMA; IN-VITRO; FLUID RESUSCITATION; PLATELET-AGGREGATION; EXTRACELLULAR-MATRIX; TRAUMA RESUSCITATION; TRANSFUSION POLICIES; APHERESIS PLATELETS AB Recent combat experience reignited interest in transfusing whole blood (WB) for patients with life-threatening bleeding. US Army data indicate that WB transfusion is associated with improved or comparable survival compared to resuscitation with blood components. These data complement randomized controlled trials that indicate that platelet (PLT)-containing blood products stored at 4 degrees C have superior hemostatic function, based on reduced bleeding and improved functional measures of hemostasis, compared to PLT-containing blood products at 22 degrees C. WB is rarely available in civilian hospitals and as a result is rarely transfused for patients with hemorrhagic shock. Recent developments suggest that impediments to WB availability can be overcome, specifically the misconceptions that WB must be ABO specific, that WB cannot be leukoreduced and maintain PLTs, and finally that cold storage causes loss of PLT function. Data indicate that the use of low anti-A and anti-B titer group O WB is safe as a universal donor, WB can be leukoreduced with PLT-sparing filters, and WB stored at 4 degrees C retains PLT function during 15 days of storage. The understanding that these perceived barriers are not insurmountable will improve the availability of WB and facilitate its use. In addition, there are logistic and economic advantages of WB-based resuscitation compared to component therapy for hemorrhagic shock. The use of low-titer group O WB stored for up to 15 days at 4 degrees C merits further study to compare its efficacy and safety with current resuscitation approaches for all patients with life-threatening bleeding. C1 [Spinella, Philip C.] Washington Univ, Dept Pediat, Div Crit Care, St Louis, MO 63110 USA. [Spinella, Philip C.; Pidcoke, Heather F.; Cap, Andrew P.] US Army, Inst Surg Res, Jbsa Ft Sam Houston, TX USA. [Strandenes, Geir] Norwegian Naval Special Operat Commando, Bergen, Norway. [Strandenes, Geir; Hervig, Tor] Haukeland Hosp, Dept Immunol & Transfus Med, N-5021 Bergen, Norway. [Fisher, Andrew] 75th Ranger Regiment, Ft Benning, GA USA. [Jenkins, Donald] Mayo Clin, Dept Surg, Coll Med, Med Director,Trauma Ctr, Rochester, MN USA. [Stubbs, James] Mayo Clin, Dept Lab Med & Pathol, Div Transfus Med, Rochester, MN USA. [Yazer, Mark] Univ Pittsburgh, Dept Pathol, Pittsburgh, PA USA. [Yazer, Mark] Inst Transfus Med, Pittsburgh, PA USA. [Murdock, Alan] Univ Pittsburgh, Dept Surg, Pittsburgh, PA USA. [Murdock, Alan] Allegheny Gen Hosp, Div Trauma, Pittsburgh, PA 15212 USA. [Sailliol, Anne] French Mil Blood Transfus Ctr, Clamart, France. [Ness, Paul M.] Johns Hopkins Med Inst, Transfus Med Div, Dept Pathol, Baltimore, MD 21205 USA. RP Spinella, PC (reprint author), Washington Univ, Dept Pediat, Div Crit Care, St Louis, MO 63110 USA. EM Spinella_P@kids.wustl.edu RI Fisher, Andrew/M-8683-2015 OI Fisher, Andrew/0000-0003-1994-7774 NR 77 TC 3 Z9 3 U1 2 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 EI 1537-2995 J9 TRANSFUSION JI Transfusion PD APR PY 2016 VL 56 SU 2 SI SI BP S190 EP S202 DI 10.1111/trf.13491 PG 13 WC Hematology SC Hematology GA DK1ZK UT WOS:000374714200012 PM 27100756 ER PT J AU Woolley, T Badloe, J Bohonek, M Taylor, AL Heier, HE Doughty, H AF Woolley, Tom Badloe, John Bohonek, Milos Taylor, Audra L. Heier, Hans Erik Doughty, Heidi TI NATO Blood Panel perspectives on changes to military prehospital resuscitation policies: current and future practice SO TRANSFUSION LA English DT Article ID FRESH WHOLE-BLOOD; COMBAT CASUALTIES; IMPROVED SURVIVAL; TRANEXAMIC ACID; TRAUMA PATIENTS; TRANSFUSION; AFGHANISTAN; PLASMA; PLATELETS; TRIAL AB The North Atlantic Treaty Organization (NATO) Blood Panel exists to promote interoperability of transfusion practice between NATO partners. However, it has served as an important forum for the development of prehospital transfusion and transfusion in the austere environment. There are synergies with the trauma hemostasis and oxygen research community especially in the areas of innovation and research. Four presentations are summarized together with a review of some scientific principles. The past decade has already seen significant changes in early transfusion support. Sometimes practice has preceded the evidence and has stretched regulatory and logistic constraints. Ethical and philosophical issues are also important and require us to question should we and not just could we. The challenge for the combined communities is to continue to optimize transfusion support underpinned by evidence-based excellence. C1 [Woolley, Tom] Royal Ctr Def Med, Dept Mil Anaesthesia & Crit Care, Birmingham, W Midlands, England. [Badloe, John] SBB ASCP, Netherlands Mil Blood Bank, Consultant Transfus Med, Amsterdam, Netherlands. [Bohonek, Milos] Army Czech Republ, Mil Med Serv, Main Consultant Hematol & Blood Transfus, Prague, Czech Republic. [Taylor, Audra L.] US Army, Blood Program, Jbsa Ft Sam Houston, TX USA. [Heier, Hans Erik] Norwegian Mil Med Serv, Oslo, Norway. [Doughty, Heidi] NHS Blood & Transplant, Birmingham, W Midlands, England. [Doughty, Heidi] Queen Elizabeth Hosp, Ctr Def Pathol, RCDM, Birmingham B15 2TH, W Midlands, England. RP Woolley, T (reprint author), RCDM, ICT Ctr, Birmingham Res Pk, Birmingham B15 2SQ, W Midlands, England. EM t.woolley@nhs.net NR 26 TC 0 Z9 0 U1 1 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 EI 1537-2995 J9 TRANSFUSION JI Transfusion PD APR PY 2016 VL 56 SU 2 SI SI BP S217 EP S223 DI 10.1111/trf.13489 PG 7 WC Hematology SC Hematology GA DK1ZK UT WOS:000374714200015 PM 27100759 ER PT J AU Hoge, CW Ivany, CG Brusher, EA Brown, MD Shero, JC Adler, AB Warner, CH Orman, DT AF Hoge, Charles W. Ivany, Christopher G. Brusher, Edward A. Brown, Millard D., III Shero, John C. Adler, Amy B. Warner, Christopher H. Orman, David T. TI Transformation of Mental Health Care for US Soldiers and Families During the Iraq and Afghanistan Wars: Where Science and Politics Intersect SO AMERICAN JOURNAL OF PSYCHIATRY LA English DT Review ID POSTTRAUMATIC-STRESS-DISORDER; TRAUMATIC BRAIN-INJURY; MILITARY PERSONNEL; COMBAT DEPLOYMENT; FUNCTIONAL IMPAIRMENT; PTSD CHECKLIST; SYMPTOMS; PREVALENCE; RANDOMIZATION; POPULATION AB The cumulative strain of 14 years of war on service members, veterans, and their families, together with continuing global threats and the unique stresses of military service, are likely to be felt for years to come. Scientific as well as political factors have influenced how the military has addressed the mental health needs resulting from these wars. Two important differences between mental health care delivered during the Iraq and Afghanistan wars and previous wars are the degree to which research has directly informed care and the consolidated management of services. The U.S. Army Medical Command implemented programmatic changes to ensure delivery of high-quality standardized mental health services, including centralized workload management; consolidation of psychiatry, psychology, psychiatric nursing, and social work services under integrated behavioral health departments; creation of satellite mental health clinics embedded within brigade work areas; incorporation of mental health providers into primary care; routine mental health screening throughout soldiers' careers; standardization of clinical outcome measures; and improved services for family members. This transformation has been accompanied by reduction in psychiatric hospitalizations and improved continuity of care. Challenges remain, however, including continued underutilization of services by those most in need, problems with treatment of substance use disorders, overuse of opioid medications, concerns with the structure of care for chronic post-deployment (including postconcussion) symptoms, and ongoing questions concerning the causes of historically high suicide rates, efficacy of resilience training initiatives, and research priorities. It is critical to ensure that remaining gaps are addressed and that knowledge gained during these wars is retained and further evolved. C1 [Hoge, Charles W.] Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Silver Spring, MD USA. Off Army Surg Gen, Behav Hlth Div, Falls Church, VA USA. US Army Med Command Headquarters, Behav Hlth Div, Ft Sam Houston, TX USA. Extrem Trauma & Amputat Ctr Excellence, Dept Def & Vet Affairs, Ft Sam Houston, TX USA. 61st Multifunct Med Battal, Ft Hood, TX USA. RP Hoge, CW (reprint author), Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Silver Spring, MD USA. EM charles.w.hoge.civ@mail.mil NR 66 TC 4 Z9 4 U1 4 U2 14 PU AMER PSYCHIATRIC PUBLISHING, INC PI ARLINGTON PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA SN 0002-953X EI 1535-7228 J9 AM J PSYCHIAT JI Am. J. Psychiat. PD APR PY 2016 VL 173 IS 4 BP 334 EP 343 DI 10.1176/appi.ajp.2015.15040553 PG 10 WC Psychiatry SC Psychiatry GA DK9ZH UT WOS:000375290400009 PM 26552941 ER PT J AU Johnson, KA Dalzell, BJ Donahue, M Gourevitch, J Johnson, DL Karlovits, GS Keeler, B Smith, JT AF Johnson, Kris A. Dalzell, Brent J. Donahue, Marie Gourevitch, Jesse Johnson, Dennis L. Karlovits, Greg S. Keeler, Bonnie Smith, Jason T. TI Conservation Reserve Program (CRP) lands provide ecosystem service benefits that exceed land rental payment costs SO ECOSYSTEM SERVICES LA English DT Article DE Agriculture; Conservation reserve program; Ecosystem services; Cost-benefit analysis; Water quality; Valuation ID PRAIRIE POTHOLE REGION; WILLINGNESS-TO-PAY; WATER-QUALITY; DRINKING-WATER; NITROGEN-CYCLE; UNITED-STATES; NITRATE; VALUATION; EMISSIONS; OPPORTUNITIES AB Global demand for commodities prompted the expansion of row crop agriculture in the Upper Midwest, USA with unknown consequences for multiple ecosystem services. The Conservation Reserve Program (CRP) was designed to protect these services by paying farmers to retire environmentally sensitive land. Here we assessed whether the benefits provided by CRP's targeted retirement of agricultural land are equal to or greater in value than the cost of rental payments to farmers. We quantified the benefits of CRP lands for reducing flood damages, improving water quality and air-quality, and contributing to green-house gas mitigation in the Indian Creek watershed in Iowa. We found that for all assessed scenarios of CRP implementation, the ecosystem service benefits provided by CRP lands exceed the cost of payments to farmers. Expanding CRP implementation under one of three potential scenarios would require an average per-acre payment of $1311 over the life of a 10-year contract but would generate benefits with a net present value of between $1710 and $6401. This analysis suggests that investment in CRP in Indian Creek, and likely in other watersheds in the Upper Midwest, is justified based upon the value of public and private benefits provided by CRP lands. (C) 2016 Elsevier B.V. All rights reserved. C1 [Johnson, Kris A.] Nature Conservancy, 1101 West River Pkwy,Suite 200, Minneapolis, MN 55415 USA. [Dalzell, Brent J.] Univ Minnesota, Dept Soil Water & Climate, St Paul, MN 55108 USA. [Donahue, Marie; Gourevitch, Jesse; Keeler, Bonnie] Univ Minnesota, Inst Environm, St Paul, MN 55108 USA. [Johnson, Dennis L.] US Army Corps Engineers, Econ & Environm Anal Branch, Mississippi Valley Div, Rock Isl, IL USA. [Karlovits, Greg S.] US Army Corps Engineers, Mississippi Valley Div, Rock Isl, IL USA. [Smith, Jason T.] US Army Corps Engineers, Reg Planning & Environm Div, Mississippi Valley Div, Rock Isl, IL USA. RP Johnson, KA (reprint author), Nature Conservancy, 1101 West River Pkwy,Suite 200, Minneapolis, MN 55415 USA. EM kjohnson@tnc.org FU USDA [F14AP00712]; The Nature Conservancy; US Fish and Wildlife Service Landscape Conservation Cooperatives program FX We would like to acknowledge the USDA (Grant no. F14AP00712)-Farm Service Agency for sharing baseline information about CRP lands in Indian Creek. We also thank USGS for sharing an initial SWAT model for the Cedar Basin and the Iowa Soybean Association for providing data to assist with hydrologic model calibration and validation. In addition, we thank Elise De-Buysser for assistance with literature reviews, Lance Le of the University of Iowa IIHR for sharing precipitation data and the IA Department of Natural Resources GIS Library and the Linn County GIS Office for sharing GIS data. J Fargione, P Kareiva, and M Miller provided helpful reviews on earlier drafts of this manuscript. This research was made possible by the McKnight Foundation's generous support of The Nature Conservancy and additional support was provided by a grant from the US Fish and Wildlife Service Landscape Conservation Cooperatives program. NR 81 TC 0 Z9 0 U1 11 U2 22 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 2212-0416 J9 ECOSYST SERV JI Ecosyst. Serv. PD APR PY 2016 VL 18 BP 175 EP 185 DI 10.1016/j.ecoser.2016.03.004 PG 11 WC Ecology; Environmental Sciences; Environmental Studies SC Environmental Sciences & Ecology GA DK8XV UT WOS:000375213800016 ER PT J AU Tolisano, AM Klem, C Lustik, MB Sniezek, JC Golden, JB AF Tolisano, Anthony M. Klem, Christopher Lustik, Michael B. Sniezek, Joseph C. Golden, J. Blake TI Effect of a second primary thyroid carcinoma on patients with head and neck squamous cell carcinoma SO HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK LA English DT Article DE thyroid cancer; second primary malignancy; head and neck squamous cell carcinoma; Surveillance, Epidemiology, and End Results (SEER); survival ID LUNG-CANCER AB Background. The purpose of this study was to characterize the timing, histology, and behavior of second primary thyroid carcinoma (SPTC) developing after a diagnosis of head and neck squamous cell carcinoma (HNSCC). Methods. We conducted a retrospective review of the Surveillance, Epidemiology, and End Results (SEER) 9 database. Results. Patients with HNSCC who develop SPTC die 1.6 times sooner than those without SPTC. This effect is only seen if SPTC presents >6 months after diagnosis of HNSCC. Models were adjusted for age, sex, year of diagnosis, and location of HNSCC. There was no effect of prior radiation therapy on either mortality rates or time to development of thyroid cancer in patients with SPTC. The type of thyroid carcinoma that developed was similar between cohorts. Conclusion. The development of SPTC in patients with HNSCC results in decreased overall length of survival. (c) 2015 Wiley Periodicals, Inc. C1 [Tolisano, Anthony M.; Klem, Christopher; Golden, J. Blake] Tripler Army Med Ctr, Dept Otolaryngol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. [Lustik, Michael B.] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. [Sniezek, Joseph C.] Swedish Canc Inst, Div Head & Neck Surg, Seattle, WA USA. RP Tolisano, AM (reprint author), Tripler Army Med Ctr, Dept Otolaryngol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM anthony.tolisano@gmail.com NR 14 TC 0 Z9 0 U1 1 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1043-3074 EI 1097-0347 J9 HEAD NECK-J SCI SPEC JI Head Neck-J. Sci. Spec. Head Neck PD APR PY 2016 VL 38 SU 1 BP E890 EP E894 DI 10.1002/hed.24121 PG 5 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA DK7OU UT WOS:000375116400108 PM 25965105 ER PT J AU DeGregorio, BA Weatherhead, PJ Sperry, JH AF DeGregorio, Brett A. Weatherhead, Patrick J. Sperry, Jinelle H. TI ECOLOGY AND PREDATION BEHAVIOR OF CORN SNAKES (PANTHEROPHIS GUTTATUS) ON AVIAN NESTS SO HERPETOLOGICAL CONSERVATION AND BIOLOGY LA English DT Article DE activity patterns; behavior; Black Racers; Corn Snakes; edge effects; nest predation; Ratsnakes ID GOLDEN-CHEEKED WARBLER; SONGBIRD NESTS; VIDEO IDENTIFICATION; SEASONAL-VARIATION; RAT SNAKE; HABITAT; BIRDS; LOCATION; PATTERNS; SURVIVAL AB Relatively little is known about the ecology of free-ranging Corn Snakes (Pantherophis guttatus), although they have been implicated as regionally important avian nest predators. We used nest camera data from 97 snake predation events, 25% of which were attributable to Corn Snakes, to assess how the ecology and behavior of nest predation by Corn Snakes compares to that of sympatric snakes that predate nests. Unlike Ratsnakes (P. alleghaniensis) and Racers (Coluber constrictor), Corn Snakes more frequently preyed on nests located away from forest edges. Nest predation by Corn Snakes, like that by Ratsnakes and Racers, increased over the nesting season. Of the four snake species documented preying on nests at our site, Corn Snakes were the only exclusively nocturnal nest predator, arriving at nests between 2024 and 0220. Corn Snakes were nearly five times more likely to prey on nestlings than eggs, suggesting that they may locate nests visually during the day. On four occasions Corn Snakes arrived at nests shortly after or while other snakes preyed on nestlings, indicating that Corn Snakes may use cues provided by other snakes to locate prey. Unlike other snake species, Corn Snakes never struck at adult birds on the nest and often actually pushed sleeping adults off the nest or pushed under them to access nestlings. Although Corn Snakes do not appear to present nesting birds with unique challenges for avoiding predation, Corn Snakes do present researchers with intriguing questions about their foraging behavior. C1 [DeGregorio, Brett A.; Weatherhead, Patrick J.; Sperry, Jinelle H.] Univ Illinois, Dept Nat Resources & Environm Sci, 1102 S Goodwin Dr, Urbana, IL 61801 USA. [DeGregorio, Brett A.; Sperry, Jinelle H.] US Army Corps Engineers, ERDC CERL, 2902 Newmark Dr, Champaign, IL 61821 USA. RP DeGregorio, BA (reprint author), Univ Illinois, Dept Nat Resources & Environm Sci, 1102 S Goodwin Dr, Urbana, IL 61801 USA. EM badegregorio@gmail.com FU Construction Engineering Research Laboratory of the Engineer Research Development Center; Tim Hayden FX Funding was provided by the Construction Engineering Research Laboratory of the Engineer Research Development Center. We thank Tim Hayden for arranging funding. Special thanks to the Savannah River Ecology Lab for hosting us, particularly Tracey Tuberville and Brian Metts. We thank all of our technicians including Eric Nordberg, Mary Mack Gray, Ashley Smith, Patrick Barnhart, Patrick Roberts, Phil Vogrinc, Emily Williams, Mae Cowgill, Sara Wendt, Clay Noss, and Andrew Cronin. We thank Scott Chiavacci for assistance with nest cameras and Kirk Stodola for his statistical assistance. We also thank Dr. Jason Norman and the Hammond Hills Animal Hospital for transmitter surgeries. Animals were collected under SC Department of Natural Resources permits # G-11-03 and 23-2012A. Animal procedures conformed to permits approved by the Universities of Illinois (IACUC # 11054) and Georgia (AUP # A2011 04-007-Y2-A0). NR 31 TC 0 Z9 0 U1 11 U2 14 PU HERPETOLOGICAL CONSERVATION & BIOLOGY PI CORVALLIS PA C/O R BRUCE BURY, USGS FOREST & RANGELAND, CORVALLIS, OR 00000 USA SN 2151-0733 EI 1931-7603 J9 HERPETOL CONSERV BIO JI Herpetol. Conserv. Biol. PD APR PY 2016 VL 11 IS 1 BP 150 EP 159 PG 10 WC Zoology SC Zoology GA DK9LL UT WOS:000375251800017 ER PT J AU Hong, HX Shen, J Ng, HW Sakkiah, S Ye, H Ge, WG Gong, P Xiao, WM Tong, WD AF Hong, Huixiao Shen, Jie Ng, Hui Wen Sakkiah, Sugunadevi Ye, Hao Ge, Weigong Gong, Ping Xiao, Wenming Tong, Weida TI A Rat alpha-Fetoprotein Binding Activity Prediction Model to Facilitate Assessment of the Endocrine Disruption Potential of Environmental Chemicals SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH LA English DT Article DE model; prediction; alpha-fetoprotein; endocrine; disruption; binding; assessment ID ANDROGEN RECEPTOR ANTAGONISTS; HUMAN-IMMUNODEFICIENCY-VIRUS; HIV-1 INTEGRASE INHIBITORS; ESTROGEN-RECEPTOR; STRUCTURE ELUCIDATION; DECISION FOREST; EXPERT-SYSTEM; MOLECULAR DOCKING; CYTOCHROME-P450 CYP3A4; 4-POINT PHARMACOPHORE AB Endocrine disruptors such as polychlorinated biphenyls (PCBs), diethylstilbestrol (DES) and dichlorodiphenyltrichloroethane (DDT) are agents that interfere with the endocrine system and cause adverse health effects. Huge public health concern about endocrine disruptors has arisen. One of the mechanisms of endocrine disruption is through binding of endocrine disruptors with the hormone receptors in the target cells. Entrance of endocrine disruptors into target cells is the precondition of endocrine disruption. The binding capability of a chemical with proteins in the blood affects its entrance into the target cells and, thus, is very informative for the assessment of potential endocrine disruption of chemicals. alpha-fetoprotein is one of the major serum proteins that binds to a variety of chemicals such as estrogens. To better facilitate assessment of endocrine disruption of environmental chemicals, we developed a model for -fetoprotein binding activity prediction using the novel pattern recognition method (Decision Forest) and the molecular descriptors calculated from two-dimensional structures by Mold(2) software. The predictive capability of the model has been evaluated through internal validation using 125 training chemicals (average balanced accuracy of 69%) and external validations using 22 chemicals (balanced accuracy of 71%). Prediction confidence analysis revealed the model performed much better at high prediction confidence. Our results indicate that the model is useful (when predictions are in high confidence) in endocrine disruption risk assessment of environmental chemicals though improvement by increasing number of training chemicals is needed. C1 [Hong, Huixiao; Shen, Jie; Ng, Hui Wen; Sakkiah, Sugunadevi; Ye, Hao; Ge, Weigong; Xiao, Wenming; Tong, Weida] US FDA, Natl Ctr Toxicol Res, Div Bioinformat & Biostat, Jefferson, AR 72079 USA. [Gong, Ping] US Army, Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. RP Hong, HX (reprint author), US FDA, Natl Ctr Toxicol Res, Div Bioinformat & Biostat, Jefferson, AR 72079 USA. EM Huixiao.Hong@fda.hhs.gov; jieeshen@gmail.com; Huiwen.Ng@fda.hhs.gov; Suguna.Sakkiah@fda.hhs.gov; haoye.ecust@gmail.com; weigong.ge@fda.hhs.gov; Ping.Gong@usace.army.mil; Wenming.Xiao@fda.hhs.gov; Weida.Tong@fda.hhs.gov OI Sakkiah, Suguna Devi/0000-0002-8337-9348 NR 81 TC 2 Z9 2 U1 5 U2 11 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1660-4601 J9 INT J ENV RES PUB HE JI Int. J. Environ. Res. Public Health PD APR PY 2016 VL 13 IS 4 AR 372 DI 10.3390/ijerph13040372 PG 18 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA DK9DR UT WOS:000375231300020 PM 27023588 ER PT J AU Fellin, RE Seay, JF Gregorczyk, KN Hasselquist, L AF Fellin, Rebecca E. Seay, Joseph F. Gregorczyk, Karen N. Hasselquist, Leif TI Spatiotemporal Parameters are not Substantially Influenced by Load Carriage or Inclination During Treadmill and Overground Walking SO JOURNAL OF HUMAN KINETICS LA English DT Article DE gait; uphill; downhill; external load ID GAIT; BIOMECHANICS; SURFACES; SLOPE AB Influences of load carriage and inclination on spatiotemporal parameters were examined during treadmill and overground walking. Ten soldiers walked on a treadmill and overground with three load conditions (00 kg, 20 kg, 40 kg) during level, uphill (6% grade) and downhill (-6% grade) inclinations at self-selected speed, which was constant across conditions. Mean values and standard deviations for double support percentage, stride length and a step rate were compared across conditions. Double support percentage increased with load and inclination change from uphill to level walking, with a 0.4% stance greater increase at the 20 kg condition compared to 00 kg. As inclination changed from uphill to downhill, the step rate increased more overground (4.3 +/- 3.5 steps/min) than during treadmill walking (1.7 +/- 2.3 steps/min). For the 40 kg condition, the standard deviations were larger than the 00 kg condition for both the step rate and double support percentage. There was no change between modes for step rate standard deviation. For overground compared to treadmill walking, standard deviation for stride length and double support percentage increased and decreased, respectively. Changes in the load of up to 40 kg, inclination of 6% grade away from the level (i.e., uphill or downhill) and mode (treadmill and overground) produced small, yet statistically significant changes in spatiotemporal parameters. Variability, as assessed by standard deviation, was not systematically lower during treadmill walking compared to overground walking. Due to the small magnitude of changes, treadmill walking appears to replicate the spatiotemporal parameters of overground walking. C1 [Fellin, Rebecca E.; Seay, Joseph F.] US Army, Environm Med Res Inst, Mil Performance Div, 10 Gen Greene Ave,Bldg 42, Natick, MA 01760 USA. [Gregorczyk, Karen N.; Hasselquist, Leif] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA USA. RP Fellin, RE (reprint author), US Army, Environm Med Res Inst, Mil Performance Div, 10 Gen Greene Ave,Bldg 42, Natick, MA 01760 USA. EM rebecca.e.fellin.civ@mail.mil FU United States Army Research Institute of Environmental Medicine FX The authors thank Shane Sauer for data processing assistance as well as Carolyn K. Bensel and Jeffrey M. Schiffman for study design and implementation assistance. The authors are all employees of the Department of Defense in the United States Government. Research was supported in part by an appointment (R.E.F.) to the Postgraduate Research Participation Program funded by the United States Army Research Institute of Environmental Medicine & administered by the Oak Ridge Institute for Science and Engineering. Funding sources had no role in the study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the article for publication. Some of the results were published in the abstract form at the Annual Meeting of the American Society of Biomechanics in 2012. NR 20 TC 0 Z9 0 U1 2 U2 2 PU DE GRUYTER OPEN LTD PI WARSAW PA BOGUMILA ZUGA 32A ST, 01-811 WARSAW, POLAND SN 1640-5544 EI 1899-7562 J9 J HUM KINET JI J. Hum. Kinet. PD APR PY 2016 VL 50 IS 1 BP 27 EP 35 DI 10.1515/hukin-2015-0138 PG 9 WC Sport Sciences SC Sport Sciences GA DK5TI UT WOS:000374983000003 PM 28149338 ER PT J AU Golden, JW Maes, P Kwilas, SA Ballantyne, J Hooper, JW AF Golden, Joseph W. Maes, Piet Kwilas, Steven A. Ballantyne, John Hooper, Jay W. TI Glycoprotein-Specific Antibodies Produced by DNA Vaccination Protect Guinea Pigs from Lethal Argentine and Venezuelan Hemorrhagic Fever SO JOURNAL OF VIROLOGY LA English DT Article ID LYMPHOCYTIC CHORIOMENINGITIS VIRUS; PULMONARY SYNDROME HPS; JUNIN VIRUS; MONOCLONAL-ANTIBODIES; LASSA-VIRUS; NEUTRALIZING ANTIBODY; ENVELOPE GLYCOPROTEIN; NONHUMAN-PRIMATES; CROSS-REACTIVITY; IMMUNE PLASMA AB Several members of the Arenaviridae can cause acute febrile diseases in humans, often resulting in lethality. The use of convalescent-phase human plasma is an effective treatment in humans infected with arenaviruses, particularly species found in South America. Despite this, little work has focused on developing potent and defined immunotherapeutics against arenaviruses. In the present study, we produced arenavirus neutralizing antibodies by DNA vaccination of rabbits with plasmids encoding the full-length glycoprotein precursors of Junin virus (JUNV), Machupo virus (MACV), and Guanarito virus (GTOV). Geometric mean neutralizing antibody titers, as measured by the 50% plaque reduction neutralization test (PRNT50), exceeded 5,000 against homologous viruses. Antisera against each targeted virus exhibited limited cross-species binding and, to a lesser extent, cross-neutralization. Anti-JUNV glycoprotein rabbit antiserum protected Hartley guinea pigs from lethal intraperitoneal infection with JUNV strain Romero when the antiserum was administered 2 days after challenge and provided some protection (similar to 30%) when administered 4 days after challenge. Treatment starting on day 6 did not protect animals. We further formulated an IgG antibody cocktail by combining anti-JUNV, -MACV, and -GTOV antibodies produced in DNA-vaccinated rabbits. This cocktail protected 100% of guinea pigs against JUNV and GTOV lethal disease. We then expanded on this cocktail approach by simultaneously vaccinating rabbits with a combination of plasmids encoding glycoproteins from JUNV, MACV, GTOV, and Sabia virus (SABV). Sera collected from rabbits vaccinated with the combination vaccine neutralized all four targets. These findings support the concept of using a DNA vaccine approach to generate a potent pan-arenavirus immunotherapeutic. C1 [Golden, Joseph W.; Kwilas, Steven A.; Hooper, Jay W.] US Army, Med Res Inst Infect Dis, Dept Mol Virol, Div Virol, Ft Detrick, MD 21702 USA. [Maes, Piet] Katholieke Univ Leuven, Rega Inst Med Res, Dept Microbiol & Immunol, Lab Clin & Epidemiol Virol, Leuven, Belgium. [Ballantyne, John] Aldevron LLC, Fargo, ND USA. RP Hooper, JW (reprint author), US Army, Med Res Inst Infect Dis, Dept Mol Virol, Div Virol, Ft Detrick, MD 21702 USA. EM jay.w.hooper.civ@mail.mil OI Hooper, Jay/0000-0002-4475-0415 FU Joint Program Executive Office for Chemical and Biological Defense, Chemical Biological Medical Systems [W9113M-08-1-0008]; Military Infectious Disease Research Program; Army for Acquisition, Logistics, and Technology FX The Joint Program Executive Office for Chemical and Biological Defense, Chemical Biological Medical Systems, provided funding to John Ballantyne under grant number W9113M-08-1-0008. The Military Infectious Disease Research Program provided a Program Area T grant to Joseph W. Golden, Piet Maes, Steven A. Kwilas, and Jay W. Hooper. The Assistant Secretary of the Army for Acquisition, Logistics, and Technology provided an In-House Laboratory Independent Research grant to Joseph W. Golden. The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication. NR 61 TC 1 Z9 1 U1 2 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X EI 1098-5514 J9 J VIROL JI J. Virol. PD APR PY 2016 VL 90 IS 7 BP 3515 EP 3529 DI 10.1128/JVI.02969-15 PG 15 WC Virology SC Virology GA DK7QQ UT WOS:000375121200021 PM 26792737 ER PT J AU Eller, MA Goonetilleke, N Tassaneetrithep, B Eller, LA Costanzo, MC Johnson, S Betts, MR Krebs, SJ Slike, BM Nitayaphan, S Rono, K Tovanabutra, S Maganga, L Kibuuka, H Jagodzinski, L Peel, S Rolland, M Marovich, MA Kim, JH Michael, NL Robb, ML Streeck, H AF Eller, Michael A. Goonetilleke, Nilu Tassaneetrithep, Boonrat Eller, Leigh Anne Costanzo, Margaret C. Johnson, Susan Betts, Michael R. Krebs, Shelly J. Slike, Bonnie M. Nitayaphan, Sorachai Rono, Kathleen Tovanabutra, Sodsai Maganga, Lucas Kibuuka, Hannah Jagodzinski, Linda Peel, Sheila Rolland, Morgane Marovich, Mary A. Kim, Jerome H. Michael, Nelson L. Robb, Merlin L. Streeck, Hendrik TI Expansion of Inefficient HIV-Specific CD8 T Cells during Acute Infection SO JOURNAL OF VIROLOGY LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; CHRONIC VIRAL-INFECTION; ANTIRETROVIRAL THERAPY; TYPE-1 INFECTION; DISEASE PROGRESSION; CD27 EXPRESSION; SIV INFECTION; HEPATITIS-B; RESPONSES; VIREMIA AB Attrition within the CD4(+) T cell compartment, high viremia, and a cytokine storm characterize the early days after HIV infection. When the first emerging HIV-specific CD8(+) T cell responses gain control over viral replication it is incomplete, and clearance of HIV infection is not achieved even in the rare cases of individuals who spontaneously control viral replication to nearly immeasurably low levels. Thus, despite their partial ability to control viremia, HIV-specific CD8(+) T cell responses are insufficient to clear HIV infection. Studying individuals in the first few days of acute HIV infection, we detected the emergence of a unique population of CD38(+) CD27- CD8(+) T cells characterized by the low expression of the CD8 receptor (CD8(dim)). Interestingly, while high frequencies of HIV-specific CD8(+) T cell responses occur within the CD38(+) CD27(-) CD8(dim) T cell population, the minority populations of CD8(bright) T cells are significantly more effective in inhibiting HIV replication. Furthermore, the frequency of CD8(dim) T cells directly correlates with viral load and clinical predictors of more rapid disease progression. We found that a canonical burst of proliferative cytokines coincides with the emergence of CD8(dim) T cells, and the size of this population inversely correlates with the acute loss of CD4(+) T cells. These data indicate, for the first time, that early CD4(+) T cell loss coincides with the expansion of a functionally impaired HIV-specific CD8(dim) T cell population less efficient in controlling HIV viremia. IMPORTANCE A distinct population of activated CD8(+) T cells appears during acute HIV infection with diminished capacity to inhibit HIV replication and is predictive of viral set point, offering the first immunologic evidence of CD8(+) T cell dysfunction during acute infection. C1 [Eller, Michael A.; Eller, Leigh Anne; Costanzo, Margaret C.; Johnson, Susan; Krebs, Shelly J.; Slike, Bonnie M.; Tovanabutra, Sodsai; Jagodzinski, Linda; Peel, Sheila; Rolland, Morgane; Marovich, Mary A.; Kim, Jerome H.; Michael, Nelson L.; Robb, Merlin L.; Streeck, Hendrik] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Eller, Michael A.; Eller, Leigh Anne; Costanzo, Margaret C.; Johnson, Susan; Krebs, Shelly J.; Slike, Bonnie M.; Tovanabutra, Sodsai; Rolland, Morgane; Robb, Merlin L.; Streeck, Hendrik] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Goonetilleke, Nilu] Univ N Carolina, Dept Immunol & Microbiol, Chapel Hill, NC USA. [Tassaneetrithep, Boonrat] Mahidol Univ, Siriraj Hosp, Fac Med, Off Res & Dev, Bangkok 10700, Thailand. [Betts, Michael R.] Univ Penn, Dept Microbiol, Perelman Sch Med, Philadelphia, PA 19104 USA. [Nitayaphan, Sorachai] USAMC AFRIMS, Dept Retrovirol, Bangkok, Thailand. [Rono, Kathleen] Walter Reed Project Kenya, Kericho, Kenya. [Maganga, Lucas] Walter Reed Program Tanzania, Mbeya, Tanzania. [Kibuuka, Hannah] Makerere Univ, Walter Reed Project, Kampala, Uganda. [Streeck, Hendrik] Univ Duisburg Essen, Univ Hosp Essen, Inst HIV Res, Essen, Germany. [Kim, Jerome H.] Int Vaccine Inst, Seoul, South Korea. [Marovich, Mary A.] NIAID, 9000 Rockville Pike, Bethesda, MD 20892 USA. RP Streeck, H (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.; Streeck, H (reprint author), Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.; Streeck, H (reprint author), Univ Duisburg Essen, Univ Hosp Essen, Inst HIV Res, Essen, Germany. EM Hendrik.streeck@uk-essen.de FU Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-11-2-0174]; U.S. Department of Defense (DoD) [W81XWH-11-2-0174] FX This work was supported by a cooperative agreement (W81XWH-11-2-0174) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense (DoD). NR 38 TC 3 Z9 3 U1 1 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X EI 1098-5514 J9 J VIROL JI J. Virol. PD APR PY 2016 VL 90 IS 8 BP 4005 EP 4016 DI 10.1128/JVI.02785-15 PG 12 WC Virology SC Virology GA DK7RQ UT WOS:000375123800019 PM 26842474 ER PT J AU Zander, NE Gillan, M Sweetser, D AF Zander, Nicole E. Gillan, Margaret Sweetser, Daniel TI Recycled PET Nanofibers for Water Filtration Applications SO MATERIALS LA English DT Article DE electrospinning; nanofibers; recycled PET; water filtration; antimicrobial ID MEMBRANES; COMPOSITE; SCAFFOLDS; OSMOSIS AB Water shortage is an immediate and serious threat to our world population. Inexpensive and scalable methods to clean freshwater and wastewater are in high demand. Nanofiber filtration membranes represent a next generation nonwoven filter media due to their unique properties. Polyethlyene terephthalate (PET) is often used in the packaging of water and other commonly used materials, leading to a large amount of plastic waste often with limited incentive for recycling (few value-added uses). Here, we present work in the generation of nanofiber liquid filtration membranes from PET plastic bottles and demonstrate their use in microfiltration. PET nanofiber membranes were formed via solution electrospinning with fiber diameters as low as ca. 100 nm. Filtration efficiency was tested with latex beads with sizes ranging from 30 to 2000 nm. Greater than 99% of the beads as small as 500 nm were removed using gravity filtration. To reduce biofouling, the mats were functionalized with quaternary ammonium and biguanide biocides. The biguanide functionalized mats achieved 6 log reduction for both gram negative and gram positive bacteria. C1 [Zander, Nicole E.; Gillan, Margaret; Sweetser, Daniel] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, Aberdeen, MD 21005 USA. RP Zander, NE (reprint author), US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, Aberdeen, MD 21005 USA. EM nicole.e.zander.civ@mail.mil; margaret.gillan2.ctr@mail.mil; sweetser@udel.edu NR 26 TC 1 Z9 1 U1 22 U2 44 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1996-1944 J9 MATERIALS JI Materials PD APR PY 2016 VL 9 IS 4 AR 247 DI 10.3390/ma9040247 PG 10 WC Materials Science, Multidisciplinary SC Materials Science GA DK8EB UT WOS:000375158900033 ER PT J AU Treangen, TJ Schoeler, G Phillippy, AM Bergman, NH Turell, MJ AF Treangen, Todd J. Schoeler, George Phillippy, Adam M. Bergman, Nicholas H. Turell, Michael J. TI Identification and Genomic Analysis of a Novel Group C Orthobunyavirus Isolated from a Mosquito Captured near Iquitos, Peru SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID AEDES-ALBOPICTUS; DIPTERA-CULICIDAE; UNITED-STATES; SINGLE-CELL; VIRUS; SEQUENCES; ALIGNMENT; VALLEY; BUNYAVIRUSES; TRANSMISSION AB Group C orthobunyaviruses are single-stranded RNA viruses found in both South and North America. Until very recently, and despite their status as important vector-borne human pathogens, no Group C whole genome sequences containing all three segments were available in public databases. Here we report a Group C orthobunyavirus, named El Huayo virus, isolated from a pool of Culex portesi mosquitoes captured near Iquitos, Peru. Although initial metagenomic analysis yielded only a handful of reads belonging to the genus Orthobunyavirus, single contig assemblies were generated for L, M, and S segments totaling over 200,000 reads (similar to 0.5% of sample). Given the moderately high viremia in hamsters (>10(7) plaque-forming units/ml) and the propensity for Cx. portesi to feed on rodents, it is possible that El Huayo virus is maintained in nature in a Culex portesi/rodent cycle. El Huayo virus was found to be most similar to Peruvian Caraparu virus isolates and constitutes a novel sub-clade within Group C. C1 [Treangen, Todd J.; Phillippy, Adam M.; Bergman, Nicholas H.] Natl Biodef Anal & Countermeasures Ctr, Frederick, MD USA. [Schoeler, George] US Naval Med Res Unit 6, Dept Entomol, Callao, Peru. [Turell, Michael J.] US Army, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. [Schoeler, George] Bur Med & Surg, Falls Church, VA USA. [Phillippy, Adam M.] NHGRI, Genome Informat Sect, Computat & Stat Genom Branch, NIH, Bethesda, MD 20892 USA. RP Treangen, TJ (reprint author), Natl Biodef Anal & Countermeasures Ctr, Frederick, MD USA. EM treangent@nbacc.net FU Department of Homeland Security (DHS) Science and Technology Directorate (ST) [HSHQDC-07-C-00020]; Federally Funded Research and Development Center FX This work was funded under Agreement No. HSHQDC-07-C-00020 awarded by the Department of Homeland Security (DHS) Science and Technology Directorate (S&T) for the management and operation of the National Biodefense Analysis and Countermeasures Center (NBACC), a Federally Funded Research and Development Center. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 50 TC 0 Z9 0 U1 0 U2 0 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD APR PY 2016 VL 10 IS 4 AR e0004440 DI 10.1371/journal.pntd.0004440 PG 13 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA DL1FC UT WOS:000375376700007 PM 27074162 ER PT J AU Blasch, K Kolivosky, J Hill, B AF Blasch, Kyle Kolivosky, John Hill, Barry TI Occupational exposures among personnel working near combined burn pit and incinerator operations at Bagram Airfield, Afghanistan SO INHALATION TOXICOLOGY LA English DT Article DE Burn pit; incinerator; inhalation exposurePAHparticulate matter ID RESPIRATORY SYMPTOMS; MILITARY PERSONNEL; DEPLOYED SETTINGS; HEALTH; IRAQ; EMISSIONS; VETERANS; ILLNESS; INJURY; IMPACT AB Occupational air samples were collected at Bagram Airfield Afghanistan for security forces (SF) stationed at the perimeter of the solid waste disposal facility that included a burn pit, air curtain destructors, and solid waste and medical waste incinerators. The objective of the investigation was to quantify inhalation exposures of workers near the disposal facility. Occupational air sample analytes included total particulates not otherwise specified (PNOS), respirable PNOS, acrolein and polyaromatic hydrocarbons (PAH). Exposures were measured for four SF job specialties. Thirty 12-hour shifts were monitored from November 2011 to March 2012. The geometric means for respirable particulate matter and PAH for all job specialties were below the 12-hour adjusted American Conference of Governmental Industrial Hygienists threshold limit value time weighted averages (TLV-TWA). The geometric mean of the respirable particulate matter 12-hour TWAs for the four job specialties ranged from 0.116 to 0.134 mg/m(3). One measurement collected at the tower (3.1 mg/m(3)) position exceeded the TLV-TWA. Naphthalene and pyrene were the only PAHs detected in multiple samples of the 18 PAHs analyzed. The geometric mean concentration for naphthalene was 9.39E-4 mg/m(3) and the maximum concentration was 0.0051 mg/m(3). The geometric mean of acrolein for the four job specialties ranged from 0.021 to 0.047 mg/m(3). There were four exceedances of the Occupational Safety and Health Administration 8-hour permissible exposure limit-time weighted average (PEL-TWA), respectively, ranging from 0.13 to 0.32 mg/m(3). C1 [Blasch, Kyle] USAF, 230 Collins Rd, Boise, ID 83702 USA. [Kolivosky, John] US Army, Inst Publ Hlth, Aberdeen Proving Ground, MD USA. [Hill, Barry] US Air Force Sch Aerosp Med, Wright Patterson AFB, OH USA. RP Blasch, K (reprint author), USAF, 230 Collins Rd, Boise, ID 83702 USA. EM kblasch@usgs.gov FU U.S. Department of Defense FX Funding for this investigation was provided by the U.S. Department of Defense. NR 30 TC 1 Z9 1 U1 5 U2 6 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0895-8378 EI 1091-7691 J9 INHAL TOXICOL JI Inhal. Toxicol. PD APR PY 2016 VL 28 IS 5 BP 216 EP 225 DI 10.3109/08958378.2016.1145768 PG 10 WC Toxicology SC Toxicology GA DK0VX UT WOS:000374631400002 PM 27092584 ER PT J AU Herzig, MC Cap, AP AF Herzig, Maryanne C. Cap, Andrew P. TI Challenges in translating mesenchymal stem cell therapies for trauma and critical care SO TRANSFUSION LA English DT Editorial Material ID DAMAGE CONTROL RESUSCITATION; STROMAL CELLS; CLINICAL-APPLICATIONS; ADIPOSE-TISSUE; INJURY; ADULT; TUMORIGENICITY; MSC; REGENERATION; TRANSFUSION C1 [Herzig, Maryanne C.; Cap, Andrew P.] US Army, Coagulat & Blood Res Program, Inst Surg Res, JBSA Ft Sam Houston, San Antonio, TX USA. RP Cap, AP (reprint author), US Army, Med Corps, Chicago, IL USA.; Cap, AP (reprint author), US Army, Blood Res, Inst Surg Res, Chicago, IL USA.; Cap, AP (reprint author), Uniformed Serv Univ Hlth Sci, Med, Bethesda, MD USA.; Cap, AP (reprint author), San Antonio Mil Med Ctr, 3650 Chambers Pass, Jbsa Ft Sam Houston, TX 78234 USA. EM andrew.p.cap.mil@mail.mil NR 75 TC 0 Z9 0 U1 1 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 EI 1537-2995 J9 TRANSFUSION JI Transfusion PD APR PY 2016 VL 56 IS 4 BP 20S EP 25S DI 10.1111/trf.13566 PG 6 WC Hematology SC Hematology GA DJ6ST UT WOS:000374343900007 PM 27079318 ER PT J AU Dye, JM Warfield, KL Wells, JB Unfer, RC Shulenin, S Vu, H Nichols, DK Aman, MJ Bavari, S AF Dye, John M. Warfield, Kelly L. Wells, Jay B. Unfer, Robert C. Shulenin, Sergey Vu, Hong Nichols, Donald K. Aman, M. Javad Bavari, Sina TI Virus-Like Particle Vaccination Protects Nonhuman Primates from Lethal Aerosol Exposure with Marburgvirus (VLP Vaccination Protects Macaques against Aerosol Challenges) SO VIRUSES-BASEL LA English DT Article DE Marburg virus; virus-like particle; vaccine; macaque; aerosol; adjuvant ID EBOLA-VIRUS; GUINEA-PIGS; HEMORRHAGIC-FEVER; INFECTION; VACCINES; OUTBREAK; IMMUNOGENICITY; NUCLEOPROTEIN; GLYCOPROTEIN; IMMUNIZATION AB Marburg virus (MARV) was the first filovirus to be identified following an outbreak of viral hemorrhagic fever disease in Marburg, Germany in 1967. Due to several factors inherent to filoviruses, they are considered a potential bioweapon that could be disseminated via an aerosol route. Previous studies demonstrated that MARV virus-like particles (VLPs) containing the glycoprotein (GP), matrix protein VP40 and nucleoprotein (NP) generated using a baculovirus/insect cell expression system could protect macaques from subcutaneous (SQ) challenge with multiple species of marburgviruses. In the current study, the protective efficacy of the MARV VLPs in conjunction with two different adjuvants: QS-21, a saponin derivative, and poly I:C against homologous aerosol challenge was assessed in cynomolgus macaques. Antibody responses against the GP antigen were equivalent in all groups receiving MARV VLPs irrespective of the adjuvant; adjuvant only-vaccinated macaques did not demonstrate appreciable antibody responses. All macaques were subsequently challenged with lethal doses of MARV via aerosol or SQ as a positive control. All MARV VLP-vaccinated macaques survived either aerosol or SQ challenge while animals administered adjuvant only exhibited clinical signs and lesions consistent withMARV disease and were euthanized after meeting the predetermined criteria. Therefore, MARV VLPs induce IgG antibodies recognizing MARV GP and VP40 and protect cynomolgus macaques from an otherwise lethal aerosol exposure with MARV. C1 [Dye, John M.; Wells, Jay B.; Nichols, Donald K.; Bavari, Sina] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Warfield, Kelly L.; Unfer, Robert C.; Shulenin, Sergey; Vu, Hong; Aman, M. Javad] Integrated Biotherapeut Inc, Gaithersburg, MD 20878 USA. RP Dye, JM (reprint author), US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.; Warfield, KL (reprint author), Integrated Biotherapeut Inc, Gaithersburg, MD 20878 USA. EM john.m.dye1.civ@mail.mil; warfieldk@ebsi.com; jay.b.wells.ctr@mail.mil; Robert.unfer@nih.gov; sergey@integratedbiotherapeutics.com; hong@integratedbiotherapeutics.com; donald.k.nichols.civ@mail.mil; javad@integratedbiotherapeutics.com; sina.bavari.civ@mail.mil FU Defense Threat Reduction Agency JSTO-CBD FX The research described herein was sponsored by the Defense Threat Reduction Agency JSTO-CBD. The authors thank Sean VanTongeren, Kelly Stuthman, Dave Dyer, Kathy Kuehl, Atefeh Rezaie, Clare Davis, and Shawn Conley for excellent technical assistance, Erica Ollman Saphire and Marnie Fusco for provision of the GP expression construct, Daniel Levey, Charlotte Kensil, and Steve Monks of Agneus, Inc. for provision of QS-21 adjuvant and A. Salazar of Oncovir for provision of polyI:C adjuvant. Opinions, conclusions, interpretations, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army. The mention of trade names or commercial products does not constitute endorsement or recommendation for use by the Department of the Army or the Department of Defense. NR 53 TC 0 Z9 0 U1 2 U2 4 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1999-4915 J9 VIRUSES-BASEL JI Viruses-Basel PD APR PY 2016 VL 8 IS 4 AR 94 DI 10.3390/v8040094 PG 15 WC Virology SC Virology GA DK8DQ UT WOS:000375157800008 PM 27070636 ER PT J AU Ewers, EC Pratt, WD Twenhafel, NA Shamblin, J Donnelly, G Esham, H Wlazlowski, C Johnson, JC Botto, M Hensley, LE Goff, AJ AF Ewers, Evan C. Pratt, William D. Twenhafel, Nancy A. Shamblin, Joshua Donnelly, Ginger Esham, Heather Wlazlowski, Carly Johnson, Joshua C. Botto, Miriam Hensley, Lisa E. Goff, Arthur J. TI Natural History of Aerosol Exposure with Marburg Virus in Rhesus Macaques SO VIRUSES-BASEL LA English DT Article DE filovirus; nonhuman primate; Marburg virus; aerosol; telemetry; animal model ID EBOLA HEMORRHAGIC-FEVER; CYNOMOLGUS MACAQUES; INFECTED PATIENTS; ANGOLA INFECTION; ZAIRE-EBOLAVIRUS; DISEASE; PATHOGENESIS; APOPTOSIS; COAGULATION; RESPONSES AB Marburg virus causes severe and often lethal viral disease in humans, and there are currently no Food and Drug Administration (FDA) approved medical countermeasures. The sporadic occurrence of Marburg outbreaks does not allow for evaluation of countermeasures in humans, so therapeutic and vaccine candidates can only be approved through the FDA animal rule-a mechanism requiring well-characterized animal models in which efficacy would be evaluated. Here, we describe a natural history study where rhesus macaques were surgically implanted with telemetry devices and central venous catheters prior to aerosol exposure with Marburg-Angola virus, enabling continuous physiologic monitoring and blood sampling without anesthesia. After a three to four day incubation period, all animals developed fever, viremia, and lymphopenia before developing tachycardia, tachypnea, elevated liver enzymes, decreased liver function, azotemia, elevated D-dimer levels and elevated pro-inflammatory cytokines suggesting a systemic inflammatory response with organ failure. The final, terminal period began with the onset of sustained hypotension, dehydration progressed with signs of major organ hypoperfusion (hyperlactatemia, acute kidney injury, hypothermia), and ended with euthanasia or death. The most significant pathologic findings were marked infection of the respiratory lymphoid tissue with destruction of the tracheobronchial and mediastinal lymph nodes, and severe diffuse infection in the liver, and splenitis. C1 [Ewers, Evan C.; Twenhafel, Nancy A.; Goff, Arthur J.] Tripler Army Med Ctr, Dept Med, Honolulu, HI 96859 USA. [Pratt, William D.; Twenhafel, Nancy A.; Shamblin, Joshua; Donnelly, Ginger; Esham, Heather; Wlazlowski, Carly; Botto, Miriam; Goff, Arthur J.] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Johnson, Joshua C.; Hensley, Lisa E.] NIAID, Integrated Res Facil, NIH, Frederick, MD 21702 USA. RP Pratt, WD (reprint author), US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. EM evan.c.ewers.mil@mail.mil; william.d.pratt4.ctr@mail.mil; nancy.a.twenhafel.mil@mail.mil; joshua.d.shamblin1.civ@mail.mil; ginger.c.donnelly.ctr@mail.mil; heather.l.esham.civ@mail.mil; carly.b.wlazlowski.ctr@mail.mil; joshua.johnson@nih.gov; miriam.a.botto.civ@mail.mil; lisa.hensley@nih.gov; arthur.j.goff.civ@mail.mil OI Johnson, Joshua/0000-0002-5677-3841; Ewers, Evan/0000-0002-1384-9973 FU Defense Threat Reduction Agency FX Financial contributions for this work were provided by the Defense Threat Reduction Agency. The authors acknowledge the contributions of Shannan Hall-Ursone for implant and catheter surgery of the animals, and David O'Brien and Wendy Giles for technical expertise with these studies. NR 40 TC 0 Z9 0 U1 2 U2 3 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1999-4915 J9 VIRUSES-BASEL JI Viruses-Basel PD APR PY 2016 VL 8 IS 4 AR 87 DI 10.3390/v8040087 PG 16 WC Virology SC Virology GA DK8DQ UT WOS:000375157800001 PM 27043611 ER PT J AU Shurtleff, AC Bloomfield, HA Mort, S Orr, SA Audet, B Whitaker, T Richards, MJ Bavari, S AF Shurtleff, Amy C. Bloomfield, Holly A. Mort, Shannon Orr, Steven A. Audet, Brian Whitaker, Thomas Richards, Michelle J. Bavari, Sina TI Validation of the Filovirus Plaque Assay for Use in Preclinical Studies SO VIRUSES-BASEL LA English DT Article DE plaque assay; filovirus; Ebola; ebolavirus; Marburgvirus; Marburg virus; Vero E6 cells; GLP compliant; validation; animal rule ID EBOLA-VIRUS; NONHUMAN-PRIMATES; MARBURG-VIRUS; CYNOMOLGUS MACAQUES; INFECTIONS; VARIANTS; CULTURE; GUINEA AB A plaque assay for quantitating filoviruses in virus stocks, prepared viral challenge inocula and samples from research animals has recently been fully characterized and standardized for use across multiple institutions performing Biosafety Level 4 (BSL-4) studies. After standardization studies were completed, Good Laboratory Practices (GLP)-compliant plaque assay method validation studies to demonstrate suitability for reliable and reproducible measurement of the Marburg Virus Angola (MARV) variant and Ebola Virus Kikwit (EBOV) variant commenced at the United States Army Medical Research Institute of Infectious Diseases (USAMRIID). The validation parameters tested included accuracy, precision, linearity, robustness, stability of the virus stocks and system suitability. The MARV and EBOV assays were confirmed to be accurate to +/- 0.5 log(10) PFU/mL. Repeatability precision, intermediate precision and reproducibility precision were sufficient to return viral titers with a coefficient of variation (%CV) of <= 30%, deemed acceptable variation for a cell-based bioassay. Intraclass correlation statistical techniques for the evaluation of the assay's precision when the same plaques were quantitated by two analysts returned values passing the acceptance criteria, indicating high agreement between analysts. The assay was shown to be accurate and specific when run on Nonhuman Primates (NHP) serum and plasma samples diluted in plaque assay medium, with negligible matrix effects. Virus stocks demonstrated stability for freeze-thaw cycles typical of normal usage during assay retests. The results demonstrated that the EBOV and MARV plaque assays are accurate, precise and robust for filovirus titration in samples associated with the performance of GLP animal model studies. C1 [Shurtleff, Amy C.; Bavari, Sina] US Army, Med Res Inst Infect Dis, Mol & Translat Sci Div, 1425 Porter St, Frederick, MD 21702 USA. [Bloomfield, Holly A.] US Army, Med Res Inst Infect Dis, Ctr Aerobiol Studies, 1425 Porter St, Frederick, MD 21702 USA. [Mort, Shannon; Orr, Steven A.] US Army, Med Res Inst Infect Dis, Nonclin Dev Div, 1425 Porter St, Frederick, MD 21702 USA. [Audet, Brian; Whitaker, Thomas; Richards, Michelle J.] US Army, Med Res Inst Infect Dis, Cell Culture Lab, Div Virol, 1425 Porter St, Frederick, MD 21702 USA. RP Shurtleff, AC (reprint author), US Army, Med Res Inst Infect Dis, Mol & Translat Sci Div, 1425 Porter St, Frederick, MD 21702 USA. EM amy.c.shurtleff.ctr@mail.mil; holly.a.bloomfield.civ@mail.mil; shannon.m.mort.ctr@mail.mil; sorr@southernresearch.org; brian.e.audet.civ@mail.mil; thomas.j.whitaker26.ctr@mail.mil; michelle.j.richards.civ@mail.mil; sina.bavari.civ@mail.mil FU USAMRIID FX The opinions, interpretations, conclusions and recommendations in the manuscript are those of the authors and are not necessarily endorsed by the U.S. Army. The authors would like to thank Stephanie Valdez, Deepmala Yadav, Prashant Yadav, Joseph Burns, Kristine Farrar and Lucinda Leaman of the USAMRIID Cell Culture Laboratory, as well as Susan Newcomb and Maureen Baran for quality control of the data. The authors would also like to thank Dennis Taylor for project management and coordination support of this research, as well Donna Hering, Han Seung, Susan Godfrey and Carolyn Mentzer of USAMRIID Quality Assurance and Regulatory Compliance Office (QARCO) for their role in the quality assurance on this GLP study. We would also like to thank Steven J. Kern, Biostatistician, for guidance and ICC analyses, and John C. Trefry and Anna N. Honko for their scientific input at the early stages of the work. This work was supported by USAMRIID institutional funds for GLP assay validation. NR 29 TC 0 Z9 0 U1 1 U2 1 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1999-4915 J9 VIRUSES-BASEL JI Viruses-Basel PD APR PY 2016 VL 8 IS 4 AR 113 DI 10.3390/v8040113 PG 20 WC Virology SC Virology GA DK8DQ UT WOS:000375157800025 PM 27110807 ER PT J AU Moody, ML Palomino, N Weyl, PSR Coetzee, JA Newman, RM Harms, NE Liu, X Thum, RA AF Moody, Michael L. Palomino, Nayell Weyl, Philip S. R. Coetzee, Julie A. Newman, Raymond M. Harms, Nathan E. Liu, Xing Thum, Ryan A. TI Unraveling the biogeographic origins of the Eurasian watermilfoil (Myriophyllum spicatum) invasion in North America SO AMERICAN JOURNAL OF BOTANY LA English DT Article DE aquatic plant; biocontrol; Eurasian watermilfoil; hybrid; invasion pathway; invasive plant; Myriophyllum sibiricum; Myriophyllum spicatum; phylogeography ID BIOLOGICAL-CONTROL; PHYLOGENETIC INFERENCE; MULTIPLE INTRODUCTIONS; EUHRYCHIOPSIS-LECONTEI; MAXIMUM-LIKELIHOOD; PLANT INVASIONS; EXOTIC PLANT; SOUTH-AFRICA; HYBRIDIZATION; HALORAGACEAE AB PREMISE OF THE STUDY: Using phylogeographic analyses to determine the geographic origins of biological invaders is important for identifying environmental adaptations and genetic composition in their native range as well as biocontrol agents among indigenous herbivores. Eurasian watermilfoil (Myriophyllum spicatum) and its hybrid with northern watermilfoil (M. sibiricum) are found throughout the contiguous United States and southern Canada, forming one of the most economically costly aquatic plant invasions in North America, yet the geographic origin of the invasion remains unknown. The objectives of our study included determining the geographic origin of Eurasian watermilfoil in North America as well as the maternal lineage of the hybrids. METHODS: DNA sequence data from a cpDNA intron and the nrDNA ITS region were compiled for accessions from 110 populations of Eurasian watermilfoil and hybrids from North America and the native range (including Europe, Asia, and Africa). Datasets were analyzed using statistical parsimony and Bayesian phylogenetics to assess the geographic origin of the invasion. KEY RESULTS: The two Eurasian watermilfoil cpDNA haplotypes in North America are also found from China and Korea, but not elsewhere in the native range. These haplotypes did not overlap and were limited in native geographic range. The ovule parent for hybrids can come from either parental lineage, and multiple haplotypes from both parental species were found. CONCLUSIONS: The geographic origin of this prolific aquatic plant invasion of North America is in Asia. This provides critical information to better understand the invasion pathway and inform management into the future. C1 [Moody, Michael L.; Palomino, Nayell] Univ Texas El Paso, Dept Biol Sci, El Paso, TX 79968 USA. [Weyl, Philip S. R.; Coetzee, Julie A.] Rhodes Univ, Dept Zool & Entomol, ZA-6140 Grahamstown, South Africa. [Newman, Raymond M.] Univ Minnesota, Dept Fisheries Wildlife & Conservat Biol, St Paul, MN 55108 USA. [Harms, Nathan E.] US Army, Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS USA. [Liu, Xing] Wuhan Univ, Coll Life Sci, Lab Plant Systemat & Evolutionary Biol, Wuhan 430072, Hubei, Peoples R China. [Thum, Ryan A.] Montana State Univ, Dept Plant Sci & Plant Pathol, Bozeman, MT 59717 USA. RP Moody, ML (reprint author), Univ Texas El Paso, Dept Biol Sci, El Paso, TX 79968 USA. EM mlmoody@utep.edu OI Weyl, Philip/0000-0002-0121-7266 FU Working for Water Program of the Natural Resource Management Programmes (Department of Environmental Affairs), South Africa; University of Minnesota CFANS faculty development award; University of Texas at El Paso URI and COURI programs; Aquatic Plant Control Research Program of the U.S. Army Corps of Engineers FX We thank S. Arshid, R. Capers, S. Compton, A. Gander, P. Grillas, I. Gunn, B. Hellquist, L. Henderson, D. Impson, S. Jeong, C. Lambertini, R. Mangan, R. Monge, S. Park, J. Parsons, T. Riis, R. Sforza, K. Steffen, and X. Xu for providing plant specimens to make this study possible. Assistance with molecular data was provided by C. Anderson, M. Jeffers, S. Parks, J. Pashnick, A. Pyman, and D. Wcisel. We thank two anonymous reviewers for comments that improved the manuscript. The Working for Water Program of the Natural Resource Management Programmes (Department of Environmental Affairs), South Africa; University of Minnesota CFANS faculty development award; University of Texas at El Paso URI and COURI programs; and the Aquatic Plant Control Research Program of the U.S. Army Corps of Engineers are thanked for their financial support of this project. NR 54 TC 0 Z9 0 U1 16 U2 27 PU BOTANICAL SOC AMER INC PI ST LOUIS PA PO BOX 299, ST LOUIS, MO 63166-0299 USA SN 0002-9122 EI 1537-2197 J9 AM J BOT JI Am. J. Bot. PD APR PY 2016 VL 103 IS 4 BP 709 EP 718 DI 10.3732/ajb.1500476 PG 10 WC Plant Sciences SC Plant Sciences GA DJ3ZA UT WOS:000374144000014 PM 27033316 ER PT J AU Nichols, RA Niagro, FD Borke, JL Cuenin, MF AF Nichols, Richard A., Jr. Niagro, Frank D. Borke, James L. Cuenin, Michael F. TI Mechanical Stretching of Mouse Calvarial Osteoblasts In Vitro Models Changes in MMP-2 and MMP-9 Expression at the Bone-Implant Interface SO JOURNAL OF ORAL IMPLANTOLOGY LA English DT Article DE bone; osteoblast; cyclic mechanical stretch; RT-PCR; zymography; metalloproteinase; MMP; TIMP ID MATRIX METALLOPROTEINASES; COLLAGENASE; INVITRO; STRAIN; CELLS AB Bone to mechanical loading elicits a biological response that has clinical significance for several areas in dental medicine, including orthodontic tooth movement, tempromandibular joint disease, and endosseous dental implant osseointegration. Human orthopedic studies of failed hip implant sites have identified increased mRNA expression of several collagen-degrading matrix metalloproteinases (MMPs), while in vitro experiments have shown increases in MMP secretion after exposure to inflammatory mediators. This investigation evaluates the effects of mechanical deformation on in vitro osteoblasts by assessing changes in MMP gene expression and enzyme activity. We seeded mouse neonatal calvarial osteoblasts onto flexible 6-well plates and subjected to continuous cyclic mechanical stretching. The expression and activity of mRNA for several MMPs (2, 3, 9, and 10) was assessed. When subjected to mechanical stress in culture, only mRNA specific for MMP-9 was significantly increased compared to nonstretched controls (P < .005). Measurement of MMP activity by gelatin zymography demonstrated that none of the MMPs showed increased activity with stretching; however, MMP-2 activity decreased. Our results suggest that in response to stretch, MMP-2 responds rapidly by inhibiting conversion of a MMP-2 to the active form, while a slower up-regulation of MMP-9 may play a role in the long-term remodeling of extracellular matrix in response to continuous mechanical loading. This study suggests that the regulation of metalloproteinases at both the mRNA and protein level are important in the response of bone to mechanical stress. C1 [Nichols, Richard A., Jr.] US Army Periodont Residency Program, Dent Act, Ft Gordon, GA USA. [Niagro, Frank D.] Dwight D Eisenhower Army Med Ctr, Clin Invest Div, Ft Gordon, GA USA. [Borke, James L.] Western Univ Hlth Sci, Coll Dent Med, Pomona, CA USA. [Cuenin, Michael F.] Carolina Ctr Restorat Dent, Mt Pleasant, SC USA. RP Borke, JL (reprint author), Western Univ Hlth Sci, Coll Dent Med, Pomona, CA USA. EM jborke@westernu.edu NR 26 TC 0 Z9 0 U1 2 U2 4 PU ALLEN PRESS INC PI LAWRENCE PA 810 E 10TH ST, LAWRENCE, KS 66044 USA SN 0160-6972 EI 1548-1336 J9 J ORAL IMPLANTOL JI J. Oral Implant. PD APR PY 2016 VL 42 IS 2 BP 138 EP 144 DI 10.1563/aaid-joi-D-14-00199 PG 7 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA DJ4TZ UT WOS:000374202200004 PM 25961753 ER PT J AU Connelly, BC Steenbergen, EH Smith, HE Elhamri, S Mitchel, WC Mou, S Metcalfe, GD Brown, GJ Wraback, M AF Connelly, Blair C. Steenbergen, Elizabeth H. Smith, Howard E. Elhamri, Said Mitchel, William C. Mou, Shin Metcalfe, Grace D. Brown, Gail J. Wraback, Michael TI Dependence of minority carrier lifetime of Be-doped InAs/InAsSb type-II infrared superlattices on temperature and doping density SO PHYSICA STATUS SOLIDI B-BASIC SOLID STATE PHYSICS LA English DT Article; Proceedings Paper CT Compound Semiconductor Week (CSW) / 42nd International Symposium on Compound Semiconductors (ISCS) / 27th International Conferences on Indium Phos-phide and Related Materials (IPRM) CY JUN 28-JUL 02, 2015 CL Santa Barbara, CA DE beryllium doping; InAs; minority-carrier lifetime; time-resolved photoluminescence; type-II superlattices AB We investigate the minority carrier lifetime of Be-doped InAs/InAsSb type-II superlattices as a function of doping density and temperature using time-resolved photoluminescence (TRPL) to determine if switching the superlattice type from the typical n-type residual carrier concentration to p-type may improve device performance by improving the lifetime-mobility product. The introduction of the Be dopant to the superlattice reduces the carrier lifetime, first by a factor of approximate to 3 for doping densities near or below the n-type residual carrier concentration, then by an order of magnitude for samples doped well above the residual carrier concentration. Further, the higher-doped p-type samples demonstrate two distinct TRPL decay regimes and two peaks in the PL spectra, suggesting the formation of an additional acceptor-related recombination pathway leading to the observed shorter carrier lifetime. C1 [Connelly, Blair C.; Metcalfe, Grace D.; Wraback, Michael] US Army, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. [Steenbergen, Elizabeth H.; Mitchel, William C.; Mou, Shin; Brown, Gail J.] US Air Force, Res Lab, Mat & Mfg Directorate, Wright Patterson AFB, OH 45433 USA. [Smith, Howard E.] Univ Dayton, Res Inst, Dayton, OH 45469 USA. [Elhamri, Said] Univ Dayton, Dept Phys, Dayton, OH 45469 USA. RP Connelly, BC (reprint author), US Army, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. EM blair.connelly.civ@mail.mil; elizabeth.steenbergen.1@us.af.mil NR 17 TC 0 Z9 0 U1 7 U2 15 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 0370-1972 EI 1521-3951 J9 PHYS STATUS SOLIDI B JI Phys. Status Solidi B-Basic Solid State Phys. PD APR PY 2016 VL 253 IS 4 BP 630 EP 634 DI 10.1002/pssb.201552497 PG 5 WC Physics, Condensed Matter SC Physics GA DJ3YL UT WOS:000374142500005 ER PT J AU Karabiyik, M Ahmadivand, A Sinha, R Al-Amin, C Vabbina, PK Kaya, S Rupper, G Rudin, S Shur, M Pala, N AF Karabiyik, Mustafa Ahmadivand, Arash Sinha, Raju Al-Amin, Chowdhury Vabbina, Phani Kiran Kaya, Serkan Rupper, Greg Rudin, Sergey Shur, Michael Pala, Nezih TI Plasmonic properties of asymmetric dual grating gate plasmonic crystals SO PHYSICA STATUS SOLIDI B-BASIC SOLID STATE PHYSICS LA English DT Article; Proceedings Paper CT Compound Semiconductor Week (CSW) / 42nd International Symposium on Compound Semiconductors (ISCS) / 27th International Conferences on Indium Phos-phide and Related Materials (IPRM) CY JUN 28-JUL 02, 2015 CL Santa Barbara, CA DE plasmonic crystals; THz oscillations; two-dimensional electron gas ID ELECTRON-MOBILITY TRANSISTORS; FIELD-EFFECT TRANSISTOR; TERAHERTZ RADIATION; FLUID; WAVES; MODES AB We report on numerical study of dispersion properties and frequency dependent absorption characteristics of asymmetric dual grating gate terahertz (THz) plasmonic crystals. The study shows that the dispersion relations of plasmons in a two-dimensional electron gas (2DEG) capped with asymmetric dual grating gates have energy band gaps in the Brillion zones. Depending on the wave vector, the plasmons can have symmetrical, anti-symmetrical, and asymmetrical charge distributions that are different from the ones for uniform gratings case. Plasmons in the studied plasmonic crystal exhibit both tightly confined/weakly coupled behavior and propagating/strongly coupled behavior depending on the plasmonic modes. The responsivity of the plasmonic detector based on asymmetric dual grating gate does not monotonically decrease with the frequency, which is in contrast to the responsivity of uniform grating THz detectors. The cross-section of an asymmetric dual grating gate terahertz plasmonic device under THz illumination is represented, where excited plasmons are shown in red. C1 [Karabiyik, Mustafa; Ahmadivand, Arash; Sinha, Raju; Al-Amin, Chowdhury; Vabbina, Phani Kiran; Kaya, Serkan; Pala, Nezih] Florida Int Univ, Dept Elect & Comp Engn, Miami, FL 33172 USA. [Rupper, Greg; Rudin, Sergey] US Army Res Lab, Adelphi, MD 20783 USA. [Shur, Michael] Rensselaer Polytech Inst, Troy, NY 12180 USA. RP Karabiyik, M (reprint author), Florida Int Univ, Dept Elect & Comp Engn, Miami, FL 33172 USA. EM mustafakarabiyik@gmail.com FU Army Research Laboratory (ARL) Multiscale Multidisciplinary Modeling of Electronic Materials (MSME) Collaborative Research Alliance (CRA) [W911NF-12-2-0023]; Army Research Office [W911NF-12-1-0071] FX This work is supported by Army Research Laboratory (ARL) Multiscale Multidisciplinary Modeling of Electronic Materials (MSME) Collaborative Research Alliance (CRA) (Grant No. W911NF-12-2-0023) and Army Research Office (Grant No. W911NF-12-1-0071). NR 18 TC 0 Z9 0 U1 2 U2 3 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 0370-1972 EI 1521-3951 J9 PHYS STATUS SOLIDI B JI Phys. Status Solidi B-Basic Solid State Phys. PD APR PY 2016 VL 253 IS 4 BP 671 EP 675 DI 10.1002/pssb.201552609 PG 5 WC Physics, Condensed Matter SC Physics GA DJ3YL UT WOS:000374142500013 ER PT J AU Delaney, HM Lucero, PF Maves, RC Lawler, JV Maddry, JK Biever, KA Womble, SG Coffman, RV Murray, CK AF Delaney, Heather M. Lucero, Pedro F. Maves, Ryan C. Lawler, James V. Maddry, Joseph K. Biever, Kimberlie A. Womble, Shannon G. Coffman, Robert V. Murray, Clinton K. TI Ebola Virus Disease Simulation Case Series Patient With Ebola Virus Disease in the Prodromal Phase of Illness (Scenario 1), the "Wet" Gastrointestinal Phase of Illness (Scenario 2), and the Late, Critically Ill Phase of Disease (Scenario 3) SO SIMULATION IN HEALTHCARE-JOURNAL OF THE SOCIETY FOR SIMULATION IN HEALTHCARE LA English DT Article DE Ebola virus disease; Highly infectious diseases; Disaster preparedness; Simulation; Crisis team training ID AFRICA AB Introduction: As part of an international response to the Ebola virus disease (EVD) outbreak, the US Department of Defense has deployed thousands of personnel to help train and augment international health care workers. The transmission risk of this deadly virus to health care workers has been extreme, demonstrating the importance of safe practices while caring for these patients. Medical simulation training is well recognized as an integral component for disease outbreak preparedness. Therefore, the US Government created a program of instruction that outlines a formalized EVD training program, using high-fidelity simulation, which projects both an understanding of the disease and its transmission risks. Methods: Two 5-day training courses were established to provide training to the 65-member Department of Defense Ebola Response Team, which would be activated during a stateside Ebola outbreak. This training consisted of Ebola-specific protocols, personal protective equipment familiarization, and scenario-based certification for physicians, nurses, and public health trainers. Simulation was used to replicate the work environment inside an Ebola treatment unit. Results: Three comprehensive clinical scenarios covering a wide spectrum of EVD presentations were designed around details of published cases to provide the most realistic and relevant EVD training available. The authors conducted 10 iterations of the 3 EVD clinical scenarios totaling more than 1100 hours of simulation training. Conclusions: Quality practical exercises to include specialized task performance and collective teamwork training relied heavily on dedicated facilities and realistic medical simulation resulting in valuable lessons learned. In future iterations, these characteristics would be imperative to a successful training course. C1 [Delaney, Heather M.; Lucero, Pedro F.; Maves, Ryan C.; Lawler, James V.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Delaney, Heather M.; Lucero, Pedro F.; Maddry, Joseph K.; Biever, Kimberlie A.; Womble, Shannon G.; Coffman, Robert V.; Murray, Clinton K.] Brooke Army Med Ctr, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. [Maves, Ryan C.] Naval Med Ctr San Diego, San Diego, CA USA. [Lawler, James V.] Naval Med Res Ctr, Dept Clin Res, Frederick, MD USA. RP Delaney, HM (reprint author), Brooke Army Med Ctr, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM heather.m.delaney.mil@mail.mil FU Brooke Army Medical Center Command; Army North FX The authors would like to sincerely thank all members of the Brooke Army Medical Center Simulation Team for working tirelessly to carry out these simulations. Also, they would like to thank key members of the critical care nursing leadership for their support during this training. They would like to thank Army North and the Brooke Army Medical Center Command for their support and expertise during this training. NR 15 TC 0 Z9 0 U1 2 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1559-2332 EI 1559-713X J9 SIMUL HEALTHC JI Simul. Healthc. PD APR PY 2016 VL 11 IS 2 BP 106 EP 116 DI 10.1097/SIH.0000000000000115 PG 11 WC Health Care Sciences & Services SC Health Care Sciences & Services GA DJ5VG UT WOS:000374277600008 PM 27043096 ER PT J AU DeGregorio, BA Weatherhead, PJ Ward, MP Sperry, JH AF DeGregorio, Brett A. Weatherhead, Patrick J. Ward, Michael P. Sperry, Jinelle H. TI Do seasonal patterns of rat snake (Pantherophis obsoletus) and black racer (Coluber constrictor) activity predict avian nest predation? SO ECOLOGY AND EVOLUTION LA English DT Article DE Activity patterns; automated radiotelemetry; nest cameras; nest survival; northern cardinal; predator-prey ID SONGBIRD NESTS; FOREST FRAGMENTATION; GRASSLAND BIRDS; HOME RANGES; OLD FIELDS; HABITAT; MOVEMENTS; SURVIVAL; THERMOREGULATION; LANDSCAPE AB Avian nest success often varies seasonally and because predation is the primary cause of nest failure, seasonal variation in predator activity has been hypothesized to explain seasonal variation in nest success. Despite the fact that nest predator communities are often diverse, recent evidence from studies of snakes that are nest predators has lent some support to the link between snake activity and nest predation. However, the strength of the relationship has varied among studies. Explaining this variation is difficult, because none of these studies directly identified nest predators, the link between predator activity and nest survival was inferred. To address this knowledge gap, we examined seasonal variation in daily survival rates of 463 bird nests (of 17 bird species) and used cameras to document predator identity at 137 nests. We simultaneously quantified seasonal activity patterns of two local snake species (N=30 individuals) using manual (2136 snake locations) and automated (89,165 movements detected) radiotelemetry. Rat snakes (Pantherophis obsoletus), the dominant snake predator at the site (similar to 28% of observed nest predations), were most active in late May and early June, a pattern reported elsewhere for this species. When analyzing all monitored nests, we found no link between nest predation and seasonal activity of rat snakes. When analyzing only nests with known predator identities (filmed nests), however, we found that rat snakes were more likely to prey on nests during periods when they were moving the greatest distances. Similarly, analyses of all monitored nests indicated that nest survival was not linked to racer activity patterns, but racer-specific predation (N=17 nests) of filmed nests was higher when racers were moving the greatest distances. Our results suggest that the activity of predators may be associated with higher predation rates by those predators, but that those effects can be difficult to detect when nest predator communities are diverse and predator identities are not known. Additionally, our results suggest that hand-tracking of snakes provides a reliable indicator of predator activity that may be more indicative of foraging behavior than movement frequency provided by automated telemetry systems. C1 [DeGregorio, Brett A.; Weatherhead, Patrick J.; Ward, Michael P.; Sperry, Jinelle H.] Univ Illinois, Dept Nat Resources & Environm Sci, 1102 S Goodwin Ave, Champaign, IL 61801 USA. [DeGregorio, Brett A.; Sperry, Jinelle H.] Engn Res & Dev Ctr, Champaign, IL USA. RP DeGregorio, BA (reprint author), Univ Illinois, Dept Nat Resources & Environm Sci, 1102 S Goodwin Ave, Champaign, IL 61801 USA. EM badegregorio@gmail.com FU ERDC-CERL FX Funding was provided by ERDC-CERL and was arranged by Tim Hayden. NR 44 TC 0 Z9 0 U1 8 U2 16 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2045-7758 J9 ECOL EVOL JI Ecol. Evol. PD APR PY 2016 VL 6 IS 7 BP 2034 EP 2043 DI 10.1002/ece3.1992 PG 10 WC Ecology; Evolutionary Biology SC Environmental Sciences & Ecology; Evolutionary Biology GA DJ2RE UT WOS:000374052000012 PM 27099708 ER PT J AU Green, R Lelis, A Habersat, D AF Green, Ron Lelis, Aivars Habersat, Daniel TI Threshold-voltage bias-temperature instability in commercially-available SiC MOSFETs SO JAPANESE JOURNAL OF APPLIED PHYSICS LA English DT Article; Proceedings Paper CT International Conference on Solid State Devices and Materials (SSDM) CY SEP 27-30, 2015 CL Sapporo, JAPAN SP Japan Soc Appl Phys ID RELIABILITY; MECHANISMS; STABILITY; DEVICES; DMOSFET AB This work reports on three important aspects of threshold-voltage instability in SiC power MOSFETs: (1) the threshold-voltage bias-temperature instability observed in commercial devices from two leading manufacturers, (2) a summary of the basic mechanisms driving this instability, and (3) the need for an improved test method for evaluating these devices. Even under significant overstress conditions, no negative threshold-voltage shift was observed in the most-recent-vintage commercial devices from one of the manufacturers during a -15V, 175 degrees C negative-bias temperature stress lasting 120 h. (C) 2016 The Japan Society of Applied Physics C1 [Green, Ron; Lelis, Aivars; Habersat, Daniel] US Army Res Lab, Adelphi, MD 20783 USA. RP Lelis, A (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM aivars.j.lelis.civ@mail.mil NR 35 TC 1 Z9 1 U1 3 U2 5 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0021-4922 EI 1347-4065 J9 JPN J APPL PHYS JI Jpn. J. Appl. Phys. PD APR PY 2016 VL 55 IS 4 SI SI AR 04EA03 DI 10.7567/JJAP.55.04EA03 PG 7 WC Physics, Applied SC Physics GA DJ0YD UT WOS:000373929400004 ER PT J AU Starks, TA Miller, ML Long, JM AF Starks, T. A. Miller, M. L. Long, J. M. TI Early life history of three pelagic-spawning minnows Macrhybopsis spp. in the lower Missouri River SO JOURNAL OF FISH BIOLOGY LA English DT Article DE broadcast spawners; daily age; daily growth; diet; hatch date; otolith ID LOWER YELLOWSTONE RIVERS; SICKLEFIN CHUB; GRAPHICAL ANALYSIS; FEEDING STRATEGY; PALLID STURGEON; BRAIN PATTERNS; FISHES; HABITAT; FRAGMENTATION; OTOLITHS AB Life-history characteristics of age-0 sturgeon chub Macrhybopsis gelida, shoal chub Macrhybopsis hyostoma and sicklefin chub Macrhybopsis meeki were compared using several methods. All Macrhybopsis species consumed mostly midge pupae, but M. meeki had the most general diet (Levins' index, B = 022) compared with M. hyostoma (B = 002) and M. gelida (B = 009). Morisita's diet overlap index among species pairs ranged from 062 to 097 and was highest between M. hyostoma and M. gelida. Daily ages estimated from lapilli otoliths for each species ranged from 15 to 43 days for M. gelida, 19 to 44 for M. hyostoma and from 16 to 64 days for M. meeki. Mean growth rates ranged from 079 mm day(-1) for M. meeki to 139 mm day(-1) for M. gelida. Mortality estimates indicated high daily survivorship rates for M. meeki (0985), but could not be estimated for the other two species. Hatch date histograms were congruent with the belief that M. hyostoma and M. gelida spawn periodically from June to September. Macrhybopsis meeki, however, appeared to respond to a specific spawning cue as hatch dates were unimodal with a peak in July. These results fill a gap in current knowledge of these imperilled species that can be used to guide management decisions. (C) 2016 The Fisheries Society of the British Isles C1 [Starks, T. A.] Oklahoma State Univ, Dept Nat Resources Ecol & Management, 008 Agr Hall, Stillwater, OK 74078 USA. [Miller, M. L.] US Army, Corps Engineers, Habitat & Assessment Monitoring Program, 601 E 12th St, Kansas City, MO 64106 USA. [Long, J. M.] Oklahoma State Univ, US Geol Survey, Dept Nat Resources Ecol & Management, Oklahoma Cooperat Fish & Wildlife Res Unit, 007 Agr Hall, Stillwater, OK 74078 USA. RP Starks, TA (reprint author), Oklahoma State Univ, Dept Nat Resources Ecol & Management, 008 Agr Hall, Stillwater, OK 74078 USA. EM tstarks1990@gmail.com FU U.S. Army Corps of Engineers; U.S. Geological Survey [G12AC20430]; Oklahoma State University; Oklahoma Department of Wildlife Conservation; U.S. Geological Survey; U.S. Fish and Wildlife Service; Wildlife Management Institute FX Financial support for this publication was provided by the U.S. Army Corps of Engineers and the U.S. Geological Survey through Cooperative Agreement G12AC20430. This study was performed under the auspices of a protocol approved by the U.S. Army Corps of Engineers. T. Grabowski provided constructive comments that improved the paper. The Oklahoma Cooperative Fish and Wildlife Research Unit is supported by Oklahoma State University, Oklahoma Department of Wildlife Conservation, U.S. Geological Survey, U.S. Fish and Wildlife Service and Wildlife Management Institute. Any use of trade, firm, or product names is for descriptive purposes only and does not imply endorsement by the U.S. Government. NR 51 TC 0 Z9 0 U1 7 U2 14 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0022-1112 EI 1095-8649 J9 J FISH BIOL JI J. Fish Biol. PD APR PY 2016 VL 88 IS 4 BP 1335 EP 1349 DI 10.1111/jfb.12892 PG 15 WC Fisheries; Marine & Freshwater Biology SC Fisheries; Marine & Freshwater Biology GA DJ2BO UT WOS:000374008900004 PM 26887788 ER PT J AU Kiesling, EC AF Kiesling, Eugenia C. TI Deciphering Sun Tzu: How to Read the Art of War SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Kiesling, Eugenia C.] US Mil Acad, West Point, NY 10996 USA. RP Kiesling, EC (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 3 U2 3 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 EI 1543-7795 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 2016 VL 80 IS 2 BP 516 EP 517 PG 2 WC History SC History GA DI8KZ UT WOS:000373751200010 ER PT J AU Kim, Y Jo, H Allen, JL Choe, H Wolfenstine, J Sakamotok, J AF Kim, Yunsung Jo, Hyungyung Allen, Jan L. Choe, Heeman Wolfenstine, Jeff Sakamotok, Jeff TI The Effect of Relative Density on the Mechanical Properties of Hot-Pressed Cubic Li7La3Zr2O12 SO JOURNAL OF THE AMERICAN CERAMIC SOCIETY LA English DT Article ID CRACK DEFLECTION PROCESSES; LI-ION CONDUCTORS; SOLID-ELECTROLYTE; GRAIN-SIZE; FRACTURE-TOUGHNESS; AL; CONDUCTIVITY; CERAMICS; BATTERIES; MICROSTRUCTURE AB The effect of relative density on the hardness and fracture toughness of Al-substituted cubic garnet Li6.19Al0.27La3Zr2O12 (LLZO) was investigated. Polycrystalline LLZO was made using solid-state synthesis and hot-pressing. The relative density was controlled by varying the densification time at fixed temperature (1050 degrees C) and pressure (62 MPa). After hot-pressing, the average grain size varied from approximately 2.7-3.7 m for the 85% and 98% relative density samples, respectively. Examination of fracture surfaces revealed a transition from inter- to intragranular fracture as the relative density increased. The Vickers hardness increased with relative density up to 96%, above which the hardness was constant. At 98% relative density, the Vickers hardness was equal to the hardness measured by nanoindentation 9.1 GPa, which is estimated as the single-crystal hardness value. An inverse correlation between relative density and fracture toughness was observed. The fracture toughness increased linearly from 0.97 to 2.37 MPam for the 98% and 85% relative density samples, respectively. It is suggested that crack deflection along grain boundaries can explain the increase in fracture toughness with decreasing relative density. It was also observed that the total ionic conductivity increased from 0.0094 to 0.34 mS/cm for the 85%-98% relative density samples, respectively. The results of this study suggest that the microstructure of LLZO must be optimized to maximize mechanical integrity and ionic conductivity. C1 [Kim, Yunsung] Michigan State Univ, Dept Chem Engn & Mat Sci, E Lansing, MI 48824 USA. [Jo, Hyungyung; Choe, Heeman] Kookmin Univ, Dept Adv Mat Engn, Seoul 136702, South Korea. [Allen, Jan L.; Wolfenstine, Jeff] RDRL SED C, Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Sakamotok, Jeff] Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA. RP Kim, Y (reprint author), Michigan State Univ, Dept Chem Engn & Mat Sci, E Lansing, MI 48824 USA. EM kimyuns1@msu.edu RI Choe, Heeman/J-4053-2013 OI Choe, Heeman/0000-0002-5908-577X FU Advanced Research Projects Agency-Energy [DE-AR0000399]; U.S. Army Research Laboratory (ARL); DOE [DE-EE-00006821]; National Research Foundation (NRF) of Korea [NRF-2014R1A2A1A11052513, NRF-2012K1A3A1A12054894] FX JS and YK acknowledge the support of Advanced Research Projects Agency-Energy (DE-AR0000399); JW and JLA acknowledge the support of the U.S. Army Research Laboratory (ARL). In addition, JW acknowledge the support of DOE under contract DE-EE-00006821; HC also acknowledges the support of the National Research Foundation (NRF) of Korea (NRF-2014R1A2A1A11052513; NRF-2012K1A3A1A12054894). NR 51 TC 3 Z9 3 U1 26 U2 62 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-7820 EI 1551-2916 J9 J AM CERAM SOC JI J. Am. Ceram. Soc. PD APR PY 2016 VL 99 IS 4 BP 1367 EP 1374 DI 10.1111/jace.14084 PG 8 WC Materials Science, Ceramics SC Materials Science GA DJ0ZC UT WOS:000373931900040 ER PT J AU Satapathy, S Ahart, M Dandekar, D Hemley, RJ Schuster, B Khoma, P AF Satapathy, Sikhanda Ahart, Muhtar Dandekar, Dattatraya Hemley, Russell J. Schuster, Brian Khoma, Petro TI Single-Crystal Elastic Properties of Aluminum Oxynitride (AlON) from Brillouin Scattering SO JOURNAL OF THE AMERICAN CERAMIC SOCIETY LA English DT Article ID HIGH-PRESSURE; SPINEL; ALGORITHM; MODULI; CELL AB The Brillouin light scattering technique was used to determine experimentally the three independent elastic constants of cubic aluminum oxynitride at the ambient condition. They are C11=334.8GPa,C12=164.4GPa, and C44=178.6+/- 1.1GPa. Its bulk modulus is 221.2 GPa. The magnitude of Zener anisotropic ratio is 2.1 similar to other spinels. The anisotropic nature of the material is shown by a large variation in the Young's modulus and Poisson's ratio with crystallographic directions. The material was found to be auxetic in certain orientations. C1 [Satapathy, Sikhanda; Dandekar, Dattatraya; Schuster, Brian; Khoma, Petro] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Ahart, Muhtar; Hemley, Russell J.] Carnegie Inst Sci, Geophys Lab, 5251 Broad Branch Rd NW, Washington, DC 20015 USA. RP Satapathy, S (reprint author), US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM sikhanda.s.satapathy.civ@mail.mil FU EFree, an Energy Frontier Research Center - US Department of Energy, Office of Science, Basic Energy Science [DE-SC-0001057]; US Department of Energy/National Nuclear Security Administration [DE-NA-00006] FX This research was partially supported by EFree, an Energy Frontier Research Center funded by US Department of Energy, Office of Science, Basic Energy Science under award DE-SC-0001057 (salary support for M. A.) and the facilities used at Carnegie were supported by the US Department of Energy/National Nuclear Security Administration (DE-NA-00006, CDAC.) NR 24 TC 0 Z9 0 U1 3 U2 13 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-7820 EI 1551-2916 J9 J AM CERAM SOC JI J. Am. Ceram. Soc. PD APR PY 2016 VL 99 IS 4 BP 1383 EP 1389 DI 10.1111/jace.14065 PG 7 WC Materials Science, Ceramics SC Materials Science GA DJ0ZC UT WOS:000373931900042 ER PT J AU Ensley, TR Hu, HH Reichert, M Ferdinandus, MR Peceli, D Hales, JM Perry, JW Li, ZA Jang, SH Jen, AKY Marder, SR Hagan, DJ Van Stryland, EW AF Ensley, Trenton R. Hu, Honghua Reichert, Matthew Ferdinandus, Manuel R. Peceli, Davorin Hales, Joel M. Perry, Joseph W. Li, Zhong'an Jang, Sei-Hum Jen, Alex K. -Y. Marder, Seth R. Hagan, David J. Van Stryland, Eric W. TI Quasi-three-level model applied to measured spectra of nonlinear absorption and refraction in organic molecules SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICS LA English DT Article ID SIGNAL-PROCESSING APPLICATIONS; BOND-LENGTH ALTERNATION; OPTICAL-DATA STORAGE; 2-PHOTON ABSORPTION; POLYMETHINE DYES; 1ST HYPERPOLARIZABILITY; PERTURBATION THEORY; SOLID-STATE; CHROMOPHORES; DESIGN AB Materials with a large nonlinear refractive index (n(2)) and relatively small linear and nonlinear absorption losses, namely, two-photon absorption (2PA, of coefficient alpha(2)), have long been sought after for applications such as alloptical switching (AOS). Here we experimentally determine the linear and 2PA properties of several organic molecules, which we approximate as centrosymmetric, and use a simplified essential-state model (quasi-three-level model) to predict the dispersion of n(2). We then compare these predictions with experimental measurements of n(2) and find good agreement. Here "quasi"-three-level means using a single one-photon allowed intermediate state and multiple (here two) two-photon allowed states. This also allows predictions of the figure-of-merit (FOM), defined as the ratio of nonlinear refractive phase shift to the 2PA fractional loss, that determines the viability for such molecules to be used in device applications. The model predicts that the optimized wavelength range for a large FOM lies near the short wavelength linear absorption edge for cyanine-like dyes where the magnitude of n2 is quite large. However, 2PA bands lying close to the linear absorption edge in certain classes of molecules can greatly reduce this FOM. We identify two molecules having a large FOM for AOS. We note that the FOM is often defined as the ratio of real to imaginary parts of the third-order susceptibility (chi((3))) with multiple processes leading to both components. As explained later in this paper, such definitions require care to only include the 2PA contribution to the imaginary part of chi((3)) in regions of transparency. (C) 2016 Optical Society of America C1 [Ensley, Trenton R.; Hu, Honghua; Reichert, Matthew; Ferdinandus, Manuel R.; Peceli, Davorin; Hagan, David J.; Van Stryland, Eric W.] Univ Cent Florida, Coll Opt & Photon, CREOL, Orlando, FL 32816 USA. [Ensley, Trenton R.] US Army Res Lab, Adelphi, MD 20783 USA. [Ferdinandus, Manuel R.] Air Force Inst Technol, Dept Engn Phys, Dayton, OH 45433 USA. [Hales, Joel M.; Perry, Joseph W.; Marder, Seth R.] Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA. [Hales, Joel M.; Perry, Joseph W.; Marder, Seth R.] Georgia Inst Technol, Ctr Organ Photon & Elect, Atlanta, GA 30332 USA. [Li, Zhong'an; Jang, Sei-Hum; Jen, Alex K. -Y.] Univ Washington, Dept Mat Sci & Engn, Seattle, WA 98195 USA. [Hagan, David J.; Van Stryland, Eric W.] Univ Cent Florida, Dept Phys, Orlando, FL 32816 USA. RP Van Stryland, EW (reprint author), Univ Cent Florida, Coll Opt & Photon, CREOL, Orlando, FL 32816 USA.; Van Stryland, EW (reprint author), Univ Cent Florida, Dept Phys, Orlando, FL 32816 USA. EM ewvs@creol.ucf.edu RI Hagan, David/H-2204-2011; Reichert, Matthew/N-1191-2015 OI Hagan, David/0000-0003-2713-1767; Reichert, Matthew/0000-0003-1701-9376 FU National Science Foundation (NSF) (ECS) [1202471, MRI 1229563]; Air Force Office of Scientific Research (AFOSR) MURI [FA9550-10-1-0558] FX National Science Foundation (NSF) (ECS#1202471, MRI 1229563); Air Force Office of Scientific Research (AFOSR) MURI (FA9550-10-1-0558). NR 59 TC 4 Z9 4 U1 7 U2 13 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0740-3224 EI 1520-8540 J9 J OPT SOC AM B JI J. Opt. Soc. Am. B-Opt. Phys. PD APR 1 PY 2016 VL 33 IS 4 BP 780 EP 796 DI 10.1364/JOSAB.33.000780 PG 17 WC Optics SC Optics GA DJ3LH UT WOS:000374106200037 ER PT J AU Villazanakretzer, DL Napolitano, PG Cummings, KF Magann, EF AF Villazanakretzer, Diana L. Napolitano, Peter G. Cummings, Kelly F. Magann, Everett F. TI Fish Parasites: A Growing Concern During Pregnancy SO OBSTETRICAL & GYNECOLOGICAL SURVEY LA English DT Article ID INFECTIONS; DISEASE; NEMATODA; TAPEWORM; SALMON; IMPACT AB Intestinal parasitic worms affect more than 2 billion people worldwide according to the World Health Organization. Fish-borne parasitic infections are becoming more common with the increasing popularity of sushi, sashimi, Carpaccio, tartare, gefilte, and ceviche. The ingestion of these parasites can cause serve anemia, malabsorption, severe abdominal pain, nausea, vomiting, strong allergic reactions, and gastric ulcers. Knowledge about fish parasites and pregnancy is limited. A literature search on PubMed and Web of Science used the search terms "fish parasites" OR "diphyllobothrium" OR "anisakiasis" OR "pseudoterranova" OR ("food borne parasites" AND "fish") AND "pregnancy" OR "maternal" OR "fetus" OR "fetal" OR "newborn" OR "neonatal" OR "childbirth." No limit was put on the number of years searched. There were 281 publications identified. The abstracts of all of these publications were read. After exclusion of the articles that were not relevant to pregnancy, pregnancy outcome, and fish parasites, there were 24 articles that became the basis of this review. The pathophysiology, altered maternal immunity related to the infection, limited information about fish-borne parasitic infections and pregnancy, and treatments are discussed. The main impact of a fish-borne parasitic infection on pregnant women is anemia and altered immunity, which may increase the risk of a maternal infection. The primary fetal effects include intrauterine growth restriction and preterm delivery. Target Audience Obstetricians and gynecologists, family physicians. Learning Objectives After completing this activity, the learner should be better able to recognize the global impact of intestinal parasitic worm infections; identify the 3 fish-borne parasites that affect humans; understand the immunologic response of a pregnant patient to an invading parasite; summarize the current treatment for the fish parasites. C1 [Villazanakretzer, Diana L.; Napolitano, Peter G.] US Army Med Corps, Madigan Army Med Ctr, Dept Obstet, Joint Base Lewis McChord, WA USA. [Villazanakretzer, Diana L.; Napolitano, Peter G.] US Army Med Corps, Madigan Army Med Ctr, Dept Gynecol, Joint Base Lewis McChord, WA USA. [Cummings, Kelly F.; Magann, Everett F.] Univ Arkansas Med Sci, Little Rock, AR 72205 USA. [Magann, Everett F.] Univ Arkansas Med Sci, MFM Div, Little Rock, AR 72205 USA. RP Magann, EF (reprint author), Univ Arkansas Med Sci, Dept Obstet & Gynecol, 4301 W Markham St,Slot 518, Little Rock, AR 72205 USA. EM efmagann@uams.edu NR 22 TC 0 Z9 0 U1 3 U2 16 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0029-7828 EI 1533-9866 J9 OBSTET GYNECOL SURV JI Obstet. Gynecol. Surv. PD APR PY 2016 VL 71 IS 4 BP 253 EP 259 DI 10.1097/OGX.0000000000000303 PG 7 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA DJ0XE UT WOS:000373926900003 PM 27065071 ER PT J AU Capasso, R Rosa, T Tsou, DYA Nekhendzy, V Drover, D Collins, J Zaghi, S Camacho, M AF Capasso, Robson Rosa, Talita Tsou, David Yung-An Nekhendzy, Vladimir Drover, David Collins, Jeremy Zaghi, Soroush Camacho, Macario TI Variable Findings for Drug-Induced Sleep Endoscopy in Obstructive Sleep Apnea with Propofol versus Dexmedetomidine SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article DE propofol; dexmedetomidine; sleep endoscopy; obstructive sleep apnea; VOTE classification ID INDUCED SEDATION ENDOSCOPY; UPPER AIRWAY MORPHOLOGY; INCREASING DEPTH; MULLER MANEUVER; ANESTHESIA; MIDAZOLAM; VOLUNTEERS; MANAGEMENT; CHILDREN; EFFICACY AB Objective To compare VOTE classification findings (velum, oropharyngeal-lateral walls, tongue base, and epiglottis) for drug-induced sleep endoscopy (DISE) among patients with obstructive sleep apnea (OSA) using 2 sedation protocols. Study Design Case series with chart review. Setting Single tertiary institution. Subjects Patients with OSA who underwent DISE. Methods A total of 216 patients underwent DISE between November 23, 2011, and May 1, 2015. DISE findings based on VOTE classification were compared between patients receiving the propofol- and dexmedetomidine-based sedation protocols. Results Patients with OSA (N = 216; age, 44.3 11.7 years; body mass index, 27.9 +/- 4.8 kg/m(2)) underwent DISE with intravenous administration of propofol (n = 52) or dexmedetomidine (n = 164). There were no statistically significant differences between the 2 groups in baseline apnea-hypopnea index, oxygen desaturation index, Mallampati score, tonsil size, Epworth Sleepiness Scale score, peripheral oxygen saturation nadir, age, sex, or body mass index. Patients in the propofol group had a significantly increased likelihood of demonstrating complete tongue base obstruction (75%, 39 of 52) versus partial or no obstruction (25%, 13 of 52) in the anterior-posterior dimension, as compared with the dexmedetomidine group (complete obstruction: 42.7%, 70 of 164; partial or no obstruction: 57.3%, 94 of 164; odds ratio: 4.0; 95% confidence interval: 2.0-8.1; P = .0001). Obstruction of other airway subsites was not significantly different. Conclusion Use of propofol versus dexmedetomidine to induce sedation may have a significant effect on the pattern of upper airway obstruction observed during DISE. Randomized prospective studies are indicated to confirm these initial findings. C1 [Capasso, Robson; Rosa, Talita; Tsou, David Yung-An; Zaghi, Soroush] Stanford Univ, Dept Otolaryngol Head & Neck Surg, Div Sleep Surg, Stanford, CA 94305 USA. [Tsou, David Yung-An] China Med Univ Hosp, Dept Otolaryngol, Taichung, Taiwan. [Nekhendzy, Vladimir; Drover, David; Collins, Jeremy] Stanford Univ, Dept Anesthesiol, Stanford, CA 94305 USA. [Camacho, Macario] Tripler Army Med Ctr, Div Sleep Surg & Med, Dept Otolaryngol, Oahu, HI USA. [Camacho, Macario] Stanford Univ, Dept Otolaryngol, Div Sleep Med, Redwood City, CA USA. RP Capasso, R (reprint author), Stanford Univ, Dept Otolaryngol Head & Neck Surg, Sch Med, 801 Welch Rd, Palo Alto, CA 94305 USA. EM rcapasso@ohns.stanford.edu NR 46 TC 5 Z9 5 U1 1 U2 20 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0194-5998 EI 1097-6817 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD APR PY 2016 VL 154 IS 4 BP 765 EP 770 DI 10.1177/0194599815625972 PG 6 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA DJ2FL UT WOS:000374019100029 PM 26814208 ER PT J AU Shaw, AP Brusnahan, JS Poret, JC Morris, LA AF Shaw, Anthony P. Brusnahan, Jason S. Poret, Jay C. Morris, Lauren A. TI Thermodynamic Modeling of Pyrotechnic Smoke Compositions SO ACS SUSTAINABLE CHEMISTRY & ENGINEERING LA English DT Article DE Smoke; Obscurants; Pyrotechnics; Thermodynamics; Modeling ID BORON PHOSPHIDE; PHOSPHORUS; MUNITIONS AB Some of the most effective visible obscurants for military applications are toxic or incendiary or present serious logistical complications. Sustainable alternatives are needed to mitigate the risks of human exposure and environmental contamination. The FactSage 6.4 software package was used to model the thermodynamics of pyrotechnic smoke compositions based on boron carbide, hexachloroethane, and phosphorus. The computational results are shown to be relevant in light of prior experimental observations. Boron phosphide is proposed as a benign source of phosphorus for next-generation pyrotechnic smoke compositions. The thermodynamics of the BP-KNO3 system have been studied computationally. The results indicate that certain stoichiometries should produce elemental phosphorus upon combustion. The properties of the BP-KNO3 system are examined considering the functional requirements of smoke munitions. C1 [Shaw, Anthony P.; Poret, Jay C.; Morris, Lauren A.] US Army RDECOM ARDEC, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07806 USA. [Brusnahan, Jason S.] Def Sci & Technol Grp, Edinburgh, SA 5111, Australia. RP Shaw, AP (reprint author), US Army RDECOM ARDEC, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07806 USA. EM anthony.p.shaw.civ@mail.mil FU U.S. Army FX Zhaohua Luan, Christopher D. Haines, Rajendra K. Sadangi, and Jared D. Moretti are thanked for useful discussions. The U.S. Army is thanked for funding this work. NR 46 TC 2 Z9 2 U1 5 U2 12 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 2168-0485 J9 ACS SUSTAIN CHEM ENG JI ACS Sustain. Chem. Eng. PD APR PY 2016 VL 4 IS 4 BP 2309 EP 2315 DI 10.1021/acssuschemeng.5b01762 PG 7 WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Chemical SC Chemistry; Science & Technology - Other Topics; Engineering GA DI5QV UT WOS:000373554600050 ER PT J AU Wampler, DA Pineda, C Polk, J Kidd, E Leboeuf, D Flores, M Shown, M Kharod, C Stewart, RM Cooley, C AF Wampler, David A. Pineda, Chloe Polk, Joan Kidd, Emily Leboeuf, Dale Flores, Marti Shown, Mike Kharod, Chetan Stewart, Ronald M. Cooley, Craig TI The long spine board does not reduce lateral motion during transport-a randomized healthy volunteer crossover trial SO AMERICAN JOURNAL OF EMERGENCY MEDICINE LA English DT Article ID IMMOBILIZATION; INJURIES; PAIN AB Objective: For thirty years, emergency medical services agencies have emphasized limiting spinal motion during transport of the trauma patient to the emergency department. The long spine board (LSB) has been the mainstay of spinal motion restriction practices, despite the paucity of data to support its use. The purpose of this study was to determine reduction in lateral motion afforded by the LSB in comparison to the stretcher mattress alone. Methods: This was a randomized controlled crossover trial where healthy volunteer subjects were randomly assigned to either LSB or stretcher mattress only. All subjects were fitted with a rigid cervical collar, secured to the assigned device (including foam head blocks), and driven on a closed course with prescribed turns at a low speed (<20 mph). Upon completion, the subjects were then secured to the other device and the course was repeated. Each subject was fitted with 3 graduated-paper disks (head, chest, hip). Lasers were affixed to a scaffold attached to the stretcher bridging over the patient and aimed at the center of the concentric graduations on the disks. During transport, the degree of lateral movement was recorded during each turn. Significance was determined by t test. Results: In both groups, the head demonstrated the least motion with 0.46 +/- 0.4-cm mattress and 0.97 +/- 0.7-cm LSB (P <= .0001). The chest and hip had lateral movement with chest 1.22 +/- 0.9-cm mattress and 2.22 +/- 1.4-cm LSB (P <= .0001), and the hip 1.20 +/- 0.9-cm mattress and 1.88 +/- 1.2-cm LSB (P <= .0001), respectively. In addition, lateral movement had a significant direct correlation with body mass index. Conclusion: The stretcher mattress significantly reduced lateral movement during transport. (C) 2015 Elsevier Inc. All rights reserved. C1 [Wampler, David A.; Pineda, Chloe; Polk, Joan; Kidd, Emily; Stewart, Ronald M.; Cooley, Craig] Univ Texas Hlth Sci Ctr San Antonio, 4201 Med Dr,Suite 120, San Antonio, TX 78229 USA. [Leboeuf, Dale] US Army, Houston, TX USA. [Flores, Marti] San Antonio Fire Dept, San Antonio, TX USA. [Shown, Mike] City Schertz Emergency Med Serv, Schertz, TX USA. [Kharod, Chetan] Mil EMS & Disaster Med Fellowship, Houston, TX USA. RP Wampler, DA (reprint author), Univ Texas Hlth Sci Ctr San Antonio, 4201 Med Dr,Suite 120, San Antonio, TX 78229 USA. EM wamplerd@uthscsa.edu OI Kharod, Chetan/0000-0003-4352-8887 FU San Antonio Fire Department; SAFD Office of the Medical Director; University of Texas Health Science Center at San Antonio Department of Emergency Health Sciences FX This work was also supported, in part, by the San Antonio Fire Department and the SAFD Office of the Medical Director, along with University of Texas Health Science Center at San Antonio Department of Emergency Health Sciences internal funding. The Southwest Texas Regional Advisory Council's Research Committee also contributed intellectual effort in the design of this protocol. NR 16 TC 0 Z9 0 U1 3 U2 4 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0735-6757 EI 1532-8171 J9 AM J EMERG MED JI Am. J. Emerg. Med. PD APR PY 2016 VL 34 IS 4 BP 717 EP 721 DI 10.1016/j.ajem.2015.12.078 PG 5 WC Emergency Medicine SC Emergency Medicine GA DI4TI UT WOS:000373491800007 PM 26827233 ER PT J AU Sharp, NJ Molineux, IJ Page, MA Schofield, DA AF Sharp, Natasha J. Molineux, Ian J. Page, Martin A. Schofield, David A. TI Rapid Detection of Viable Bacillus anthracis Spores in Environmental Samples by Using Engineered Reporter Phages SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article ID DECONTAMINATION; BACTERIOPHAGE; SUBTILIS; SOIL; DNA; IDENTIFICATION; POLYMERASE; INFECTION; PROMOTER; PCR AB Bacillus anthracis, the causative agent of anthrax, was utilized as a bioterrorism agent in 2001 when spores were distributed via the U.S. postal system. In responding to this event, the Federal Bureau of Investigation used traditional bacterial culture viability assays to ascertain the extent of contamination of the postal facilities within 24 to 48 h of environmental sample acquisition. Here, we describe a low-complexity, second-generation reporter phage assay for the rapid detection of viable B. anthracis spores in environmental samples. The assay uses an engineered B. anthracis reporter phage (W beta::luxAB-2) which transduces bioluminescence to infected cells. To facilitate low-level environmental detection and maximize the signal response, expression of luxAB in an earlier version of the reporter phage (W beta::luxAB-1) was optimized. These alterations prolonged signal kinetics, increased light output, and improved assay sensitivity. Using W beta::luxAB-2, detection of B. anthracis spores was 1 CFU in 8 h from pure cultures and as low as 10 CFU/g in sterile soil but increased to 105 CFU/g in unprocessed soil due to an unstable signal and the presence of competing bacteria. Inclusion of semiselective medium, mediated by a phage-expressed antibiotic resistance gene, maintained signal stability and enabled the detection of 104 CFU/g in 6 h. The assay does not require spore extraction and relies on the phage infecting germinating cells directly in the soil sample. This reporter phage displays promise for the rapid detection of low levels of spores on clean surfaces and also in grossly contaminated environmental samples from complex matrices such as soils. C1 [Sharp, Natasha J.; Schofield, David A.] Guild BioSci, Charleston, SC USA. [Molineux, Ian J.] Univ Texas Austin, Inst Cellular & Mol Biol, Mol Biosci, Austin, TX 78712 USA. [Page, Martin A.] US Army Corps Engineersn, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL USA. RP Schofield, DA (reprint author), Guild BioSci, Charleston, SC USA. EM dschofield@guildbiosciences.com FU Defense Threat Reduction Agency [BA11PHM148]; United States Army Engineer Research and Development Center [W9132T-12-C-0017]; HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) [R01AI111535] FX Defense Threat Reduction Agency provided funding to the United States Army Engineer Research and Development Center under grant number BA11PHM148. United States Army Engineer Research and Development Center provided funding to David A. Schofield under grant number W9132T-12-C-0017. HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) provided funding to David A. Schofield under grant number R01AI111535. NR 46 TC 0 Z9 0 U1 9 U2 14 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0099-2240 EI 1098-5336 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD APR PY 2016 VL 82 IS 8 BP 2380 EP 2387 DI 10.1128/AEM.03772-15 PG 8 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA DI2RB UT WOS:000373343300016 PM 26873316 ER PT J AU Quinn, CP Sabourin, CL Schiffer, JM Niemuth, NA Semenova, VA Li, H Rudge, TL Brys, AM Mittler, RS Ibegbu, CC Wrammert, J Ahmed, R Parker, SD Babcock, J Keitel, W Poland, GA Keyserling, HL El Sahly, H Jacobson, RM Marano, N Plikaytis, BD Wright, JG AF Quinn, Conrad P. Sabourin, Carol L. Schiffer, Jarad M. Niemuth, Nancy A. Semenova, Vera A. Li, Han Rudge, Thomas L. Brys, April M. Mittler, Robert S. Ibegbu, Chris C. Wrammert, Jens Ahmed, Rafi Parker, Scott D. Babcock, Janiine Keitel, Wendy Poland, Gregory A. Keyserling, Harry L. El Sahly, Hana Jacobson, Robert M. Marano, Nina Plikaytis, Brian D. Wright, Jennifer G. TI Humoral and Cell-Mediated Immune Responses to Alternate Booster Schedules of Anthrax Vaccine Adsorbed in Humans SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID LETHAL TOXIN NEUTRALIZATION; INHALATION ANTHRAX; PROTECTIVE ANTIGEN; INTRAMUSCULAR INJECTION; INCUBATION PERIOD; ANTIBODY-RESPONSE; RANDOMIZED-TRIAL; RHESUS MACAQUES; SAFETY; MEMORY AB Protective antigen (PA)-specific antibody and cell-mediated immune (CMI) responses to annual and alternate booster schedules of anthrax vaccine adsorbed (AVA; BioThrax) were characterized in humans over 43 months. Study participants received 1 of 6 vaccination schedules: a 3-dose intramuscular (IM) priming series (0, 1, and 6 months) with a single booster at 42 months (4IM); 3-dose IM priming with boosters at 18 and 42 months (5-IM); 3-dose IM priming with boosters at 12, 18, 30, and 42 months (7-IM); the 1970 licensed priming series of 6 doses (0, 0.5, 1, 6, 12, and 18 months) and two annual boosters (30 and 42 months) administered either subcutaneously (SQ) (8-SQ) or IM (8-IM); or saline placebo control at all eight time points. Antibody response profiles included serum anti-PA IgG levels, subclass distributions, avidity, and lethal toxin neutralization activity (TNA). CMI profiles included frequencies of gamma interferon (IFN-gamma)- and interleukin 4 (IL-4)-secreting cells and memory B cells (MBCs), lymphocyte stimulation indices (SI), and induction of IFN-gamma, IL-2, IL-4, IL-6, IL-1 beta, and tumor necrosis factor alpha (TNF-alpha) mRNA. All active schedules elicited high-avidity PA-specific IgG, TNA, MBCs, and T cell responses with a mixed Th1-Th2 profile and Th2 dominance. Anti-PA IgG and TNA were highly correlated (e.g., month 7, r(2) = 0.86, P < 0.0001, log(10) transformed) and declined in the absence of boosters. Boosters administered IM generated the highest antibody responses. Increasing time intervals between boosters generated antibody responses that were faster than and superior to those obtained with the final month 42 vaccination. CMI responses to the 3-dose IM priming remained elevated up to 43 months. C1 [Quinn, Conrad P.; Schiffer, Jarad M.; Semenova, Vera A.; Li, Han; Marano, Nina; Plikaytis, Brian D.; Wright, Jennifer G.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Sabourin, Carol L.; Niemuth, Nancy A.; Rudge, Thomas L.; Brys, April M.] Battelle Mem Inst, Columbus, OH USA. [Mittler, Robert S.; Ibegbu, Chris C.; Wrammert, Jens; Ahmed, Rafi] Emory Univ, Emory Vaccine Ctr, Atlanta, GA 30322 USA. [Mittler, Robert S.; Ibegbu, Chris C.] Emory Univ, Yerkes Natl Primate Ctr, Atlanta, GA 30322 USA. [Parker, Scott D.] Univ Alabama Birmingham, Birmingham, AL USA. [Babcock, Janiine] Walter Reed Army Inst Res, Silver Spring, MD USA. [Keitel, Wendy; El Sahly, Hana] Baylor Coll Med, Houston, TX 77030 USA. [Poland, Gregory A.; Jacobson, Robert M.] Mayo Clin, Rochester, MN USA. [Keyserling, Harry L.] Emory Univ, Sch Med, Atlanta, GA USA. RP Quinn, CP (reprint author), Ctr Dis Control & Prevent, Atlanta, GA USA. EM cquinn@cdc.gov FU HHS \ Centers for Disease Control and Prevention (CDC) FX HHS vertical bar Centers for Disease Control and Prevention (CDC) provided funding to Conrad P. Quinn, Carol Sabourin, Jarad M. Schiffer, Nancy Niemuth, Vera Semenova, Han Li, Thomas L. Rudge, April Brys, Robert S. Mittler, Chris Ibegbu, Jens Wrammert, Rafi Ahmed, Scott D. Parker, Janiine Babcock, Wendy Keitel, Gregory A. Poland, Harry Keyserling, Hana El Sahly, Robert M. Jacobson, Nina Marano, Brian D. Plikaytis, and Jennifer Wright. NR 36 TC 1 Z9 1 U1 4 U2 7 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 EI 1556-679X J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD APR PY 2016 VL 23 IS 4 BP 326 EP 338 DI 10.1128/CVI.00696-15 PG 13 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA DI4SY UT WOS:000373490800009 PM 26865594 ER PT J AU Huh, J Glisson, RR Matsumoto, T Easley, ME AF Huh, Jeannie Glisson, Richard R. Matsumoto, Takumi Easley, Mark E. TI Biomechanical Comparison of Intramedullary Screw Versus Low-Profile Plate Fixation of a Jones Fracture SO FOOT & ANKLE INTERNATIONAL LA English DT Article DE Jones fracture; intramedullary screw; fifth metatarsal; plate fixation ID 5TH METATARSAL; 5TH-METATARSAL BASE; PROXIMAL 5TH-METATARSAL; STRESS-FRACTURE; MANAGEMENT; STRAINS; DISTAL AB Background: Intramedullary screw fixation of fifth metatarsal Jones fractures often produces satisfactory results, however, nonunion and refracture rates are not negligible. The low-profile hook plate is an alternative fixation method that has been promoted to offer improved rotational control at the fracture site, but this remains to be proven. The purpose of this study was to document biomechanical performance differences between this type of plate and a contemporary solid, dual-pitch intramedullary screw in a cadaveric Jones fracture model. Methods: Simulated Jones fractures were created in 8 matched pairs of fresh-frozen cadaveric fifth metatarsals. One bone from each pair was stabilized using an intramedullary TriMed Jones Screw and the other using a TriMed Jones Fracture Plate (TriMed, Inc, Santa Clarita, CA). Controlled bending and torsional loads were applied. Bending stiffness and fracture site angulation, as well as torsional stiffness, peak torque, and fracture site rotation were quantified and compared. Results: Intramedullary screw fixation demonstrated greater bending stiffness and less fracture site angulation than plate fixation during plantar-to-dorsal and lateral-to-medial bending. Torsional stiffness of screw-fixed metatarsals exceeded that of plate-fixed bones at initial loading; however, as rotation progressed, the plate resisted torque better than the screw. No difference in peak torque was demonstrable between fixation methods, but it was reached earlier in specimens fixed with screws and later in those fixed with plates as rotation progressed. Conclusion: In this cadaveric Jones fracture model, intramedullary screw fixation demonstrated bending stiffness and resistance to early torsional loading that was superior to that offered by plate fixation. Clinical Relevance: Although low-profile hook plates offer an alternative for fixation of fifth metatarsal Jones fractures, intramedullary screw fixation may provide better resistance to bending and initiation of fracture site rotation. The influence of these mechanical characteristics on fracture healing is unknown, and further clinical investigation is warranted. C1 [Huh, Jeannie] Dwight D Eisenhower Army Med Ctr, Dept Orthopaed Surg, 300 East Hosp Rd, Ft Gordon, GA 30905 USA. [Glisson, Richard R.; Easley, Mark E.] Duke Univ, Med Ctr, Dept Orthopaed Surg, Durham, NC USA. [Matsumoto, Takumi] Univ Tokyo, Tokyo, Japan. RP Huh, J (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Orthopaed Surg, 300 East Hosp Rd, Ft Gordon, GA 30905 USA. EM jhandyh@gmail.com FU TriMed (TriMed, Inc, Santa Clarita, CA) FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was funded by a research grant from TriMed (TriMed, Inc, Santa Clarita, CA). NR 22 TC 1 Z9 1 U1 0 U2 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1071-1007 EI 1944-7876 J9 FOOT ANKLE INT JI Foot Ankle Int. PD APR PY 2016 VL 37 IS 4 BP 411 EP 418 DI 10.1177/1071100715619678 PG 8 WC Orthopedics SC Orthopedics GA DI7GY UT WOS:000373668700010 PM 26637274 ER PT J AU Wu, CC Aubry, S Arsenlis, A Chung, PW AF Wu, Chi-Chin Aubry, Sylvie Arsenlis, Athanasios Chung, Peter W. TI Binary dislocation junction formation and strength in hexagonal close-packed crystals SO INTERNATIONAL JOURNAL OF PLASTICITY LA English DT Article DE Dislocations; Dynamics; Elastic material; Analytic functions ID FCC METALS; FOREST INTERACTIONS; SINGLE-CRYSTALS; PRISMATIC SLIP; MECHANISMS; DYNAMICS; PLASTICITY; SIMULATIONS; MODEL; STRESS AB This work examines binary dislocation interactions, junction formation and junction strengths in hexagonal close-packed (hcp) crystals. Through a line-tension model and dislocation dynamics (DD) simulations, the interaction and dissociation of different sets of binary junctions are investigated involving one dislocation on the (01 (1) over bar0) prismatic plane and a second dislocation on one of the following planes: (0001) basal, (1 (1) over bar 00) prismatic, (1 (1) over bar 01) primary pyramidal, or ((2) over bar 112) secondary pyramidal. Varying pairs of Burgers vectors are chosen from among the common types: the basal type : 1/3 <11<(2)over bar>0 >, prismatic type :<0001>, and pyramidal type : 1/3 <11<(23)over bar> >. For binary interaction due to dislocation intersection, both the analytical results and DD-simulations indicate a relationship between symmetry of interaction maps and the relative magnitude of the Burgers vectors that constitute the junction. Using analytical formulae, a simple regressive model is also developed to represent the junction yield surface. The equation is treated as a degenerated super elliptical equation to quantify the aspect ratio and tilting angle. The results provide analytical insights on binary dislocation interactions that may occur in general hcp metals. (c) 2015 Elsevier Ltd. All rights reserved. C1 [Wu, Chi-Chin] US Army Res Lab, Energet Mat Sci Branch, Lethal Div, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Aubry, Sylvie; Arsenlis, Athanasios] Lawrence Livermore Natl Lab, Div Mat Sci, POB 808,L-367, Livermore, CA 94551 USA. [Chung, Peter W.] Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA. [Chung, Peter W.] US Army Res Lab, Computat Sci Div, Computat & Informat Sci Directorate, Adelphi, MD 20783 USA. RP Wu, CC (reprint author), US Army Res Lab, Energet Mat Sci Branch, Lethal Div, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM chi-chin.wu.ctr@mail.mil OI Wu, Chi-Chin/0000-0002-6036-3271 FU Secure Mission Solutions, Inc. [N65235-06-D8847]; Oak Ridge Institute for Science and Education Program in Maryland [ORISE-1120-1120-99]; U.S. Department of Energy by Lawrence Livermore National Laboratory [DE-AC52-07NA27344]; Computational Sciences Division of ARL; Army Research Office [W911NF1410330]; Department of Mechanical Engineering, University of Maryland at College Park FX The corresponding author Chi-Chin Wu would like to acknowledge the support from the Secure Mission Solutions, Inc. (N65235-06-D8847) and Oak Ridge Institute for Science and Education Program in Maryland (ORISE-1120-1120-99). The simulations in this article by authors Wu and Chung were performed at the Computational and Information Sciences Directorate (CISD) of US Army Research Laboratory (ARL) using the computing resources provided by ARL High Performance Supercomputing Resource Center (DSRC). The efforts of binary interaction maps by authors Aubry and Arsenlis were performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under contract No. DE-AC52-07NA27344. Author Chung would also like to acknowledge partial support from the Computational Sciences Division of ARL, the Army Research Office (W911NF1410330) and the Department of Mechanical Engineering, University of Maryland at College Park. NR 48 TC 1 Z9 1 U1 2 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0749-6419 EI 1879-2154 J9 INT J PLASTICITY JI Int. J. Plast. PD APR PY 2016 VL 79 BP 176 EP 195 DI 10.1016/j.ijplas.2015.12.003 PG 20 WC Engineering, Mechanical; Materials Science, Multidisciplinary; Mechanics SC Engineering; Materials Science; Mechanics GA DI5PK UT WOS:000373550900007 ER PT J AU Zhu, JT Ogden, FL Lai, WC Chen, XF Talbot, CA AF Zhu, Jianting Ogden, Fred L. Lai, Wencong Chen, Xiangfeng Talbot, Cary A. TI An explicit approach to capture diffusive effects in finite water-content method for solving vadose zone flow SO JOURNAL OF HYDROLOGY LA English DT Article DE Vadose zone flow; Finite water-content method; Water content bin; Diffusivity; Explicit method ID 1D RICHARDS EQUATION; POROUS-MEDIA; SOILS; INFILTRATION; DYNAMICS AB Vadose zone flow problems are usually solved from the Richards equation. Solution to the Richards equation is generally challenging because the hydraulic conductivity and diffusivity in the equation are strongly non-linear functions of water content. The finite water-content method was proposed as an alternative general solution method of the vadose zone flow problem for infiltration, falling slugs, and vadose zone response to water table dynamics based on discretizing the water content domain into numerous bins instead of the traditional spatial discretization. In this study, we develop an improved approach to the original finite water-content method (referred to as TO method hereinafter) that better simulates diffusive effects but retains the robustness of the TO method. The approach treats advection and diffusion separately and considers diffusion on a bin by bin basis. After discretizing into water content bins, we treat the conductivity and diffusivity in individual bins as water content dependent constant evaluated at given water content corresponding to each bin. For each bin, we can solve the flow equations analytically since the hydraulic conductivity and diffusivity can be treated as a constant. We then develop solutions for each bin to determine the diffusive water amounts at each time step. The water amount ahead of the convective front for each bin is redistributed among water content bins to account for diffusive effects. The application of developed solution is straightforward only involving algebraic manipulations at each time step. The method can mainly improve water content profiles, but has no significant difference for the total infiltration rate and cumulative infiltration compared to the TO method. Although the method separately deals with advection and diffusion, it can account for the coupling effects of advection and diffusion reasonably well. (C) 2016 Elsevier B.V. All rights reserved. C1 [Zhu, Jianting; Ogden, Fred L.; Lai, Wencong; Chen, Xiangfeng] Univ Wyoming, Dept Civil & Architectural Engn, Laramie, WY 82071 USA. [Lai, Wencong] Clemson Univ, Clemson, SC 29634 USA. [Talbot, Cary A.] US Army, Corps Engineers, Engn Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. RP Zhu, JT (reprint author), Univ Wyoming, Dept Civil & Architectural Engn, Laramie, WY 82071 USA. EM jzhu5@uwyo.edu FU EPSCoR program [1135483]; NSF [EAR-1360384]; Smithsonian Tropical Research Institute; Wyoming Center for Environmental Hydrology and Geophysics (WyCEHG) EPSCoR Research Infrastructure Improvement (RII) Track-1 project - NSF; University of Wyoming [1100-21266-2015]; U.S. National Science Foundation (NSF) FX This work was partly funded by the U.S. National Science Foundation (NSF), EPSCoR program through cooperative agreement 1135483 Collaborative Research: CI-WATER, Cyberinfrastructure to Advance High Performance Water Resource Modeling, NSF EAR-1360384 WSC-Category 2 Collaborative Research: Planning and Land Management in a Tropical Ecosystem: Complexities of Land-use and Hydrology Coupling in the Panama Canal Watershed, and the Smithsonian Tropical Research Institute, the Wyoming Center for Environmental Hydrology and Geophysics (WyCEHG) EPSCoR Research Infrastructure Improvement (RII) Track-1 project, funded by NSF, and the Faculty Grant-In-Aid program at the University of Wyoming (1100-21266-2015). NR 21 TC 0 Z9 0 U1 2 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-1694 EI 1879-2707 J9 J HYDROL JI J. Hydrol. PD APR PY 2016 VL 535 BP 270 EP 281 DI 10.1016/j.jhydrol.2016.01.078 PG 12 WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA DI3TN UT WOS:000373421500023 ER PT J AU Cheppudira, B Christy, R Clifford, J AF Cheppudira, B. Christy, R. Clifford, J. TI Antinociceptive effects of pluronic lecithin organo (PLO) opioid gels in rats with thermal injury SO JOURNAL OF PAIN LA English DT Meeting Abstract C1 [Cheppudira, B.; Christy, R.; Clifford, J.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND SN 1526-5900 J9 J PAIN JI J. Pain PD APR PY 2016 VL 17 IS 4 SU 1 MA 358 BP S64 EP S65 PG 2 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA DI5EZ UT WOS:000373523000257 PM 28162596 ER PT J AU Crossland, RF Mitchell, A Macko, AR Aden, JK Campbell, JE Sheppard, FR AF Crossland, Randy F. Mitchell, Alex Macko, Antoni R. Aden, James K. Campbell, James E. Sheppard, Forest R. TI Rapid assessment of shock in a nonhuman primate model of uncontrolled hemorrhage: Association of traditional and nontraditional vital signs to mortality risk SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Nonhuman primate; rhesus macaque; hemorrhagic shock; tissue oxygen saturation; end-tidal carbon dioxide ID TIDAL CARBON-DIOXIDE; NEAR-INFRARED SPECTROSCOPY; TISSUE OXYGEN-SATURATION; CRITICALLY-ILL PATIENTS; TOTAL BLOOD-VOLUME; TRAUMA PATIENTS; CARDIAC-OUTPUT; MICROCIRCULATORY ALTERATIONS; COMBAT CASUALTY; RESUSCITATION AB BACKGROUND Heart rate (HR), systolic blood pressure (SBP) and mean arterial pressure (MAP) are traditionally used to guide patient triage and resuscitation; however, they correlate poorly to shock severity. Therefore, improved acute diagnostic capabilities are needed. Here, we correlated acute alterations in tissue oxygen saturation (StO(2)) and end-tidal carbon dioxide (ETco(2)) to mortality in a rhesus macaque model of uncontrolled hemorrhage. METHODS Uncontrolled hemorrhage was induced in anesthetized rhesus macaques by a laparoscopic 60% left-lobe hepatectomy (T = 0 minute). StO(2), ETco(2), HR, as well as invasive SBP and MAP were continuously monitored through T = 480 minutes. At T = 120 minutes, bleeding was surgically controlled, and blood loss was quantified. Data analyses compared nonsurvivors (expired before T = 480 minutes, n = 5) with survivors (survived to T = 480 minutes, n = 11) using repeated-measures analysis of variance with Bonferroni correction. All p < 0.05 was considered statistically significant. Results were reported as mean SEM. RESULTS Baseline values were equivalent between groups for each parameter. In nonsurvivors versus survivors at T = 5 minutes, StO(2) (55% +/- 10% vs. 78% +/- 3%, p = 0.02) and ETco(2) (15 +/- 2 vs. 25 +/- 2 mm Hg, p = 0.0005) were lower, while MAP (18 +/- 1 vs. 23 +/- 2 mm Hg, p = 0.2), SBP (26 +/- 2 vs. 34 +/- 3 mm Hg, p = 0.4), and HR (104 +/- 13 vs. 105 +/- 6 beats/min, p = 0.3) were similar. Association of values over T = 5-30 minutes to mortality demonstrated StO(2) and ETco(2) equivalency with a significant group effect (p 0.009 for each parameter; R-2 = 0.92 and R-2 = 0.90, respectively). MAP and SBP associated with mortality later into the shock period (p < 0.04 for each parameter; R-2 = 0.91 and R-2 = 0.89, respectively), while HR yielded the lowest association (p = 0.8, R-2 = 0.83). CONCLUSION Acute alterations in StO(2) and ETco(2) strongly associated with mortality and preceded those of traditional vital signs. The continuous, noninvasive aspects of Food and Drug Administration-approved StO(2) and ETco(2) monitoring devices provide logistical benefits over other methodologies and thus warrant further investigation. C1 [Crossland, Randy F.; Mitchell, Alex; Macko, Antoni R.; Aden, James K.; Sheppard, Forest R.] JBSA Ft Sam Houston, Naval Med Res Unit San Antonio, San Antonio, TX USA. [Aden, James K.] JBSA Ft Sam Houston, US Army, Inst Surg Res, San Antonio, TX USA. RP Sheppard, FR (reprint author), JBSA Ft Sam Houston, Naval Med Res Unit San Antonio, Dept Expeditionary & Trauma Med, 3650 Chambers Pass,Bldg 3160, San Antonio, TX 78234 USA. EM forest.r.sheppard.mil@mail.mil FU Department of Defense through BUMED Advanced Medical Development [G1017]; Office of Naval Research [G1018, G1318] FX This work was funded by the Department of Defense through BUMED Advanced Medical Development (Work Unit Number: G1017) and Office of Naval Research (Work Unit Numbers: G1018 and G1318). NR 50 TC 0 Z9 0 U1 3 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD APR PY 2016 VL 80 IS 4 BP 610 EP 616 DI 10.1097/TA.0000000000000963 PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA DI1ED UT WOS:000373237900012 PM 26808041 ER PT J AU Macko, AR Crossland, RF Cap, AP Fryer, DM Mitchell, TA Pusateri, AE Sheppard, FR AF Macko, Antoni R. Crossland, Randy F. Cap, Andrew P. Fryer, Darren M. Mitchell, Thomas A. Pusateri, Anthony E. Sheppard, Forest R. TI Control of severe intra-abdominal hemorrhage with an infusible platelet-derived hemostatic agent in a nonhuman primate (rhesus macaque) model SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE NHP; xenogeneic; shock; infusible hemostatic; PDHA ID REHYDRATED LYOPHILIZED PLATELETS; VON-WILLEBRAND-FACTOR; COMBAT CASUALTY CARE; TOTAL BLOOD-VOLUME; DRIED PLATELETS; BLEEDING-TIME; TRAUMA; XENOTRANSPLANTATION; ACTIVATION AB BACKGROUND Hemorrhage remains the leading cause of potentially survivable trauma mortality. Recent reports indicate that injuries sustained in noncompressible anatomic locations (i.e., truncal and junctional) account for 86.5% of hemorrhage-related deaths. Infusible human platelet-derived hemostatic agents (hPDHAs) represent a promising strategy to reduce blood loss from noncompressible injuries. Here, we evaluate the hemostatic efficacy of a lyophilized hPDHA in a rhesus macaque model of severe, uncontrolled hemorrhage. METHODS Hemorrhage was induced via laparoscopic 60% left-lobe hepatectomy in anesthetized rhesus macaques (T = 0 minute). Treatment infusion began with an 11-mL bolus (T = 5-6 minutes) of either 5% albumin solution (control; n = 8) or hPDHA (1.2 x 10(10) platelet equivalents, n = 8), followed by 2.8-mL/min 0.9% normal saline at T = 6-20 minutes. Resuscitation continued with normal saline (0.22 mL/kg/min) to a total volume of 20 mL/kg at T = 120 minutes, at which time surgical hemostasis was achieved and percent blood loss quantified. Animals were monitored until T = 480 minutes and then euthanized, and necropsy was performed with emphasis on intravascular and end-organ thrombi. Data are expressed as mean SEM; significance, p < 0.05. RESULTS Both groups exhibited a approximate to 70% decrease in mean arterial pressure (MAP) from T = 0-5 minutes. Percent blood loss was 44.2 +/- 3.9% in hPDHA animals, and 44.3 +/- 3.3% in controls. Survival rates were 4 of 8 for hPDHA animals and 7 of 8 for controls. Regardless of treatment, percent blood loss was greater (p < 0.02) in nonsurviving animals (55 +/- 2%, n = 5) compared with surviving animals (42% +/- 3%, n = 11). No pathologic intravascular thrombi were observed in either group. CONCLUSION The isolated administration of hPDHA did not significantly reduce blood loss; however, thrombocytopenia was not present in the model, and clinically, platelets would be administered in combination with plasma. Mortality was not statistically different between groups (p = 0.14) but was related to blood loss. Future studies should consider the use of hPDHA in combination with additional therapeutics (e.g., factors) and a model that incorporates thrombocytopenia or platelet dysfunction. C1 [Macko, Antoni R.; Crossland, Randy F.; Fryer, Darren M.; Sheppard, Forest R.] JBSA Ft Sam Houston, Naval Med Res Unit San Antonio, San Antonio, TX USA. [Cap, Andrew P.] JBSA Ft Sam Houston, US Army, Inst Surg Res, San Antonio, TX USA. [Mitchell, Thomas A.] JBSA Ft Sam Houston San Antonio, San Antonio Mil Med Ctr, San Antonio, TX USA. [Pusateri, Anthony E.] US Army, Med Res & Mat Command, Ft Detrick, MD USA. RP Sheppard, FR (reprint author), JBSA Ft Sam Houston, Dept Expeditionary & Trauma Med, Naval Med Res Unit San Antonio, 3650 Chambers Pass,Bldg 3160, Ft Sam Houston, TX 78234 USA. EM forest.r.sheppard.mil@mail.mil FU Office of Naval Research [G1318] FX This work was supported by the Office of Naval Research work unit number G1318. NR 28 TC 0 Z9 0 U1 3 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD APR PY 2016 VL 80 IS 4 BP 617 EP 624 DI 10.1097/TA.0000000000000964 PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA DI1ED UT WOS:000373237900013 PM 26808038 ER PT J AU Ciminera, P Superior, MJ Bullman, T AF Ciminera, Paul Superior, Michael J. Bullman, Tim TI Findings From the Department of Veterans Affairs Qarmat Ali Medical Surveillance Program SO MILITARY MEDICINE LA English DT Article ID LUNG-CANCER MORTALITY; HEXAVALENT CHROMIUM; EXPOSURE; WORKERS; SMOKERS AB Objective: To review the Veterans Affairs (VA) medical surveillance program for Veterans with potential hexavalent chromium (CrVI) exposure that occurred during 2003. Methods: Retrospective review of medical records of the 124 Veterans that participated in standardized, in-person clinical evaluations for possible CrVI exposure during the incident in question. The evaluations were reviewed to define population level effects. In addition, a mortality analysis was conducted for the 808 unique personal identifiers available to Veterans Health Administration. Results: Mean reported number of days exposed was 21 (median 10). A history of respiratory (n = 78) and skin (n = 38) symptoms were reported during the period of exposure. No abnormalities that were specific to chromium exposure (e.g., nasal septum perforation) were found. Eight deaths occurred between 2005 and 2012. Conclusions: The lack of severe nasal abnormalities in the VA evaluations supports a time-limited peak exposure. However, the overall low participation rate (15%) severely compromises any ability to generalize to the entire potentially exposed population. Regardless, since the actual level of exposure to CrVI will never be known with certainty, the VA will continue to monitor these Veterans with periodic evaluations to identify and manage any pathologic findings that might be associated with past CrVI exposure. C1 [Ciminera, Paul; Bullman, Tim] Vet Hlth Adm, Post Deployment Hlth Off Publ Hlth, 810 Vermont Ave NW, Washington, DC 20420 USA. [Superior, Michael J.] Reynolds Army Community Hosp, Dept Prevent Med, 4301 Wilson St, Ft Sill, OK 73503 USA. RP Ciminera, P (reprint author), Vet Hlth Adm, Post Deployment Hlth Off Publ Hlth, 810 Vermont Ave NW, Washington, DC 20420 USA. NR 14 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD APR PY 2016 VL 181 IS 4 BP 307 EP 310 DI 10.7205/MILMED-D-15-00278 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA DI3NO UT WOS:000373405600005 PM 27046175 ER PT J AU Wickwire, EM Williams, SG Roth, T Capaldi, VF Jaffe, M Moline, M Motamedi, GK Morgan, GW Mysliwiec, V Germain, A Pazdan, RM Ferziger, R Balkin, TJ MacDonald, ME Macek, TA Yochelson, MR Scharf, SM Lettieri, CJ AF Wickwire, Emerson M. Williams, Scott G. Roth, Thomas Capaldi, Vincent F. Jaffe, Michael Moline, Margaret Motamedi, Gholam K. Morgan, Gregory W. Mysliwiec, Vincent Germain, Anne Pazdan, Renee M. Ferziger, Reuven Balkin, Thomas J. MacDonald, Margaret E. Macek, Thomas A. Yochelson, Michael R. Scharf, Steven M. Lettieri, Christopher J. TI Sleep, Sleep Disorders, and Mild Traumatic Brain Injury. What We Know and What We Need to Know: Findings from a National Working Group SO NEUROTHERAPEUTICS LA English DT Article DE Sleep; Sleep disorders; Traumatic brain injury; Concussion; Insomnia; Sleep apnea ID RANDOMIZED CONTROLLED-TRIAL; COGNITIVE-BEHAVIORAL THERAPY; EXCESSIVE DAYTIME SLEEPINESS; MINOR HEAD-INJURY; WAKE DISTURBANCES; CEREBRAL-ISCHEMIA; QUALITY INDEX; REM-SLEEP; CLINICAL-SIGNIFICANCE; MILITARY VETERANS AB Disturbed sleep is one of the most common complaints following traumatic brain injury (TBI) and worsens morbidity and long-term sequelae. Further, sleep and TBI share neurophysiologic underpinnings with direct relevance to recovery from TBI. As such, disturbed sleep and clinical sleep disorders represent modifiable treatment targets to improve outcomes in TBI. This paper presents key findings from a national working group on sleep and TBI, with a specific focus on the testing and development of sleep-related therapeutic interventions for mild TBI (mTBI). First, mTBI and sleep physiology are briefly reviewed. Next, essential empirical and clinical questions and knowledge gaps are addressed. Finally, actionable recommendations are offered to guide active and efficient collaboration between academic, industry, and governmental stakeholders. C1 [Wickwire, Emerson M.] Univ Maryland, Sch Med, Dept Psychiat, Baltimore, MD 21201 USA. [Wickwire, Emerson M.; Scharf, Steven M.] Univ Maryland, Sch Med, Dept Med, Sleep Disorders Ctr,Div Pulm & Crit Care, Baltimore, MD 21201 USA. [Williams, Scott G.] Walter Reed Natl Mil Med Ctr, Dept Med, Bethesda, MD USA. [Williams, Scott G.; Mysliwiec, Vincent; Lettieri, Christopher J.] Uniformed Serv Univ Hlth Sci, Dept Med, Room A3060, Bethesda, MD 20814 USA. [Roth, Thomas] Henry Ford Hosp, Sleep Disorders & Res Ctr, Detroit, MI 48202 USA. [Capaldi, Vincent F.; Balkin, Thomas J.] Ctr Mil Psychiat & Neurosci Res, Walter Reed Army Inst Res, Dept Behav Biol, Silver Spring, MD USA. [Jaffe, Michael] Univ Florida, Dept Neurol, Gainesville, FL USA. [Jaffe, Michael] Univ Florida Trauma, Concuss & Sports Program, Gainesville, FL USA. [Jaffe, Michael] UF Hlth Sleep Disorders Ctr, Gainesville, FL USA. [Moline, Margaret] Eisai Inc, Woodcliff Lake, NJ USA. [Motamedi, Gholam K.] Georgetown Univ Hosp, Dept Neurol, Washington, DC 20007 USA. [Morgan, Gregory W.] Natl Intrepid Ctr Excellence, Sleep Disorders Ctr, Bethesda, MD USA. [Mysliwiec, Vincent] San Antonio Mil Med Ctr, Dept Sleep Med, San Antonio, TX USA. [Germain, Anne] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USA. [Pazdan, Renee M.] US PHS, Ft Carson, CO USA. [Ferziger, Reuven] Merck & Co Inc, Kenilworth, NJ USA. [MacDonald, Margaret E.] Evans Army Community Hosp, Def & Vet Brain Injury Ctr, Gen Dynam Hlth Solut, Ft Carson, CO USA. [Macek, Thomas A.] Takeda Dev Ctr Amer, CNS, Dept Clin Sci, Deerfield, IL USA. [Yochelson, Michael R.] Medstar Natl Rehabil Network, Washington, DC USA. [Yochelson, Michael R.] Georgetown Univ, Sch Med, Dept Neurol, Washington, DC USA. [Yochelson, Michael R.] Georgetown Univ, Sch Med, Dept Rehabil Med, Washington, DC USA. RP Wickwire, EM (reprint author), Univ Maryland, Sch Med, Dept Psychiat, Baltimore, MD 21201 USA.; Wickwire, EM (reprint author), Univ Maryland, Sch Med, Dept Med, Sleep Disorders Ctr,Div Pulm & Crit Care, Baltimore, MD 21201 USA. EM ewickwire@medicine.umaryland.edu NR 136 TC 2 Z9 2 U1 10 U2 17 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1933-7213 EI 1878-7479 J9 NEUROTHERAPEUTICS JI Neurotherapeutics PD APR PY 2016 VL 13 IS 2 BP 403 EP 417 DI 10.1007/s13311-016-0429-3 PG 15 WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy SC Neurosciences & Neurology; Pharmacology & Pharmacy GA DI6WY UT WOS:000373642100013 PM 27002812 ER PT J AU Herzog, MM Driban, JB Cattano, NM Cameron, KL Tourville, TW Marshall, SW Pietrosimone, B AF Herzog, M. M. Driban, J. B. Cattano, N. M. Cameron, K. L. Tourville, T. W. Marshall, S. W. Pietrosimone, B. TI RISK OF DEVELOPING KNEE OSTEOARTHRITIS OVER TWENTY-FOUR MONTHS IN PARTICIPANTS THAT DECREASE WALKING SPEED DURING A TWELVE MONTH PERIOD: AN ANALYSIS OF THE OSTEOARTHRITIS INITIATIVE SO OSTEOARTHRITIS AND CARTILAGE LA English DT Meeting Abstract CT World Congress of the Osteoarthritis-Research-Society-International (OARSI) on Osteoarthritis CY MAR 31-APR 03, 2016 CL Amsterdam, NETHERLANDS SP Osteoarthritis Res Soc Int C1 [Herzog, M. M.; Marshall, S. W.; Pietrosimone, B.] Univ N Carolina, Chapel Hill, NC USA. [Driban, J. B.] Tufts Med Ctr, Boston, MA USA. [Cattano, N. M.] West Chester Univ Penn, W Chester, PA USA. [Cameron, K. L.] Keller Army Hosp, West Point, NY USA. [Tourville, T. W.] Univ Vermont, Burlington, VT USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1063-4584 EI 1522-9653 J9 OSTEOARTHR CARTILAGE JI Osteoarthritis Cartilage PD APR PY 2016 VL 24 SU S MA 147 BP S94 EP S95 PG 2 WC Orthopedics; Rheumatology SC Orthopedics; Rheumatology GA DI5KW UT WOS:000373538800177 ER PT J AU Rhon, D Hando, B Deyle, G AF Rhon, D. Hando, B. Deyle, G. TI USE OF PHYSICAL THERAPY AND CORTICOSTEROID INJECTIONS IN THE MANAGEMENT OF KNEE OSTEOARTHRITIS IN THE US MILITARY HEALTH SYSTEM SO OSTEOARTHRITIS AND CARTILAGE LA English DT Meeting Abstract CT World Congress of the Osteoarthritis-Research-Society-International (OARSI) on Osteoarthritis CY MAR 31-APR 03, 2016 CL Amsterdam, NETHERLANDS SP Osteoarthritis Res Soc Int C1 [Rhon, D.; Deyle, G.] Brooke Army Med Ctr, San Antonio, TX USA. [Hando, B.] Natl Def Univ, Washington, DC USA. NR 0 TC 0 Z9 0 U1 3 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1063-4584 EI 1522-9653 J9 OSTEOARTHR CARTILAGE JI Osteoarthritis Cartilage PD APR PY 2016 VL 24 SU S MA 400 BP S233 EP S234 PG 2 WC Orthopedics; Rheumatology SC Orthopedics; Rheumatology GA DI5KW UT WOS:000373538800430 ER PT J AU Zubko, E Videen, G Hines, DC Shkuratov, Y AF Zubko, Evgenij Videen, Gorden Hines, Dean C. Shkuratov, Yuriy TI The positive-polarization of cometary comae SO PLANETARY AND SPACE SCIENCE LA English DT Article DE Polarization; Comets; Modeling ID DISCRETE-DIPOLE APPROXIMATION; O1 HALE-BOPP; POLARIMETRIC OBSERVATIONS; IMAGING POLARIMETRY; OPTICAL POLARIMETRY; LIGHT-SCATTERING; INFRARED OBSERVATIONS; PHASE ANGLES; B2 HYAKUTAKE; HALLEY DUST AB We examine the dispersion of the degree of linear polarization Pin comets at phase angle similar to 90 degrees where the maximum amplitude of positive polarization P-max, occurs. The range of polarization observed in comets is from 7% up to more than 30%, and this cannot be explained through depolarization by gaseous emissions. Instead, we suggest that the observed dispersion of P results from different properties in cometary dust. We simulate the spectral polarimetric observations of comets using model agglomerated debris particles. The vast majority of observations can be reproduced with a mixture of weakly absorbing and highly absorbing agglomerated debris particles, which obey the same power-law size distribution. Within this extremely simple approach, polarization at side-scattering angles in a given comet is governed by the relative abundance of weakly and strongly absorbing particles. We find that in comets with the highest polarization, the weakly absorbing particles appear in proportions of only 14-23% by volume; whereas, in comets with the lowest polarization P-max, their abundance is much greater, 82-95%. We conclude that the polarization at side-scattering angles unambiguously measures the relative abundance of Mg-rich silicates and refractory organics or amorphous carbon in comets. We put forth a hypothesis that low P-max could be an indicator for presence of a well-developed refractory surface layer covering cometary nucleus. 2015 Elsevier Ltd. All rights reserved. C1 [Zubko, Evgenij; Shkuratov, Yuriy] Kharkov Natl Univ, Inst Astron, 35 Sumskaya St, UA-61022 Kharkov, Ukraine. [Videen, Gorden; Hines, Dean C.] Space Sci Inst, 4750 Walnut St,Suite 205, Boulder, CO 80301 USA. [Videen, Gorden] INTA, Ctra Ajalvir Km 4, Madrid 28850, Spain. [Videen, Gorden] Univ Cantabria, Dept Fis Aplicada, Grp Opt, Fac Ciencias, Avda Los Castros S-N, E-39005 Santander, Spain. [Videen, Gorden] US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Hines, Dean C.] Space Telescope Sci Inst, 3700 San Martin Dr, Baltimore, MD 21218 USA. RP Zubko, E (reprint author), Kharkov Natl Univ, Inst Astron, 35 Sumskaya St, UA-61022 Kharkov, Ukraine. EM evgenij.s.zubko@gmail.com OI Zubko, Evgenij/0000-0001-9994-923X FU NASA through Space Telescope Science Institute [GO 13199, 13474]; NASA [NAS5-26555] FX This work was partially supported by NASA through a Grant (GO 13199 and 13474) provided from the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS5-26555. The authors thank Dr. Olexandra Ivanova (Main Astronomical Observatory of NAS of Ukraine) for valuable comments on this work, and two anonymous referees for their constructive reviews. NR 73 TC 1 Z9 1 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0032-0633 J9 PLANET SPACE SCI JI Planet Space Sci. PD APR PY 2016 VL 123 SI SI BP 63 EP 76 DI 10.1016/j.pss.2015.09.020 PG 14 WC Astronomy & Astrophysics SC Astronomy & Astrophysics GA DI3QZ UT WOS:000373414900008 ER PT J AU House, JM AF House, Jonathan M. TI Intercept 1961: The Birth of Soviet Missile Defense. SO RUSSIAN REVIEW LA English DT Book Review C1 [House, Jonathan M.] US Army Command & Gen Staff Coll, Leavenworth, KS 66027 USA. RP House, JM (reprint author), US Army Command & Gen Staff Coll, Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0036-0341 EI 1467-9434 J9 RUSS REV JI Russ. Rev. PD APR PY 2016 VL 75 IS 2 BP 333 EP 334 PG 2 WC History SC History GA DI6LL UT WOS:000373610300032 ER PT J AU Marsh, C AF Marsh, Christopher TI The Two Pluralisms Under the Third Rome SO SOCIETY LA English DT Article DE Russia; Forced secularization; Desecularization; Russian Orthodox Christianity; Peter Berger AB This article applies Berger's new paradigm for religion in a pluralist age to the case of Russia, a society that underwent 70 years forced secularization and yet today displays great religious diversity. The analysis rests upon two major assumptions. The first is that of "multiple secularities," meaning that societies that arrive at secularity may arrive there from very different points of departure and by following very different secularization paths, and the particular paths taken are of considerable consequence. Second is the assumption that Russia's history of forced secularization continues to have profound implications on all aspects of the sacred and the secular in Russia today. This is explored in the areas of church-state relations; religious belief; religion and national identity; and the implications of these on what Berger calls "formulas for peace." Throughout the analysis, Berger's theory proves quite valuable and offers several useful lenses through which to view the relationship between the sacred and the secular in today's Russia. C1 [Marsh, Christopher] US Army, Sch Adv Mil Studies, 201 Reynolds Ave, Ft Leavenworth, KS 66027 USA. RP Marsh, C (reprint author), US Army, Sch Adv Mil Studies, 201 Reynolds Ave, Ft Leavenworth, KS 66027 USA. EM christopher.marsh5@us.army.mil NR 18 TC 0 Z9 0 U1 3 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0147-2011 EI 1936-4725 J9 SOCIETY JI Society PD APR PY 2016 VL 53 IS 2 BP 123 EP 130 DI 10.1007/s12115-016-9987-6 PG 8 WC Social Sciences, Interdisciplinary; Sociology SC Social Sciences - Other Topics; Sociology GA DI1CS UT WOS:000373234200003 ER PT J AU Thomas, DM Branch, KR Cury, RC AF Thomas, Dustin M. Branch, Kelley R. Cury, Ricardo C. TI PROMISE of Coronary CT Angiography: Precise and Accurate Diagnosis and Prognosis in Coronary Artery Disease SO SOUTHERN MEDICAL JOURNAL LA English DT Review DE Scottish Computed Tomography of the Heart Trial; coronary computed tomography angiography; coronary artery disease; Prospective Multicenter Imaging Study for Evaluation of Chest Pain ID COMPUTED TOMOGRAPHIC ANGIOGRAPHY; INTERNATIONAL MULTICENTER REGISTRY; AMERICAN-HEART-ASSOCIATION; ALL-CAUSE MORTALITY; CARDIOVASCULAR ANGIOGRAPHY; MYOCARDIAL-INFARCTION; THORACIC SURGEONS; CLINICAL-OUTCOMES; MEDICAL THERAPY; TASK-FORCE AB Coronary computed tomography angiography (CCTA) is a rapidly growing and powerful diagnostic test that offers a great deal of precision with respect to diagnosing coronary artery disease (CAD). Guideline statements for patients with stable ischemic heart disease have recommended CCTA for only a limited portion of intermediate-risk patients who have relative or absolute contraindications for exercise or vasodilator stress testing. The publication of two large, prospective randomized clinical trials, the Prospective Multicenter Imaging Study for Evaluation of Chest Pain and the Scottish Computed Tomography of the Heart Trial are likely to expand these indications. These new data from large trials, in addition to other studies, show that CCTA is highly sensitive for the detection of CAD, identifies high-risk patients for cardiac events based on extent or plaque morphology of CAD that would not be identified by other noninvasive means, and provides significantly greater diagnostic certainty for proper treatment, including referral for invasive coronary angiography with revascularization more appropriately. Superior diagnostic accuracy and prognostic data with CCTA, when compared with other functional stress tests, may result in a reduction in unnecessary downstream testing and cost savings. In addition, newer CCTA applications hold the promise of providing a complete evaluation of a patient's coronary anatomy as well as a per-vessel ischemic evaluation. This review focuses on the interval knowledge obtained from newer data on CCTA in patients with stable ischemic heart disease, primarily focusing on the contributions of the Prospective Multicenter Imaging Study for Evaluation of Chest Pain and the Scottish Computed Tomography of the Heart Trial. C1 [Thomas, Dustin M.] Brooke Army Med Ctr, Div Cardiol, 3551 Roger Brooke Dr, San Antonio, TX 78234 USA. Univ Washington, Div Cardiol, Seattle, WA 98195 USA. Baptist Hlth South Florida, Miami Cardiac & Vasc Inst, Miami, FL USA. RP Thomas, DM (reprint author), Brooke Army Med Ctr, Div Cardiol, 3551 Roger Brooke Dr, San Antonio, TX 78234 USA. EM dustin.m.thomas4.mil@mail.mil NR 42 TC 0 Z9 0 U1 1 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0038-4348 EI 1541-8243 J9 SOUTH MED J JI South.Med.J. PD APR PY 2016 VL 109 IS 4 BP 242 EP 247 DI 10.14423/SMJ.0000000000000436 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA DI1UT UT WOS:000373282400011 PM 27043808 ER PT J AU Walsh, DV Robinson, J Jurek, GM Capo-Aponte, JE Riggs, DW Temme, LA AF Walsh, David V. Robinson, James Jurek, Gina M. Capo-Aponte, Jose E. Riggs, Daniel W. Temme, Leonard A. TI A Performance Comparison of Color Vision Tests for Military Screening SO AEROSPACE MEDICINE AND HUMAN PERFORMANCE LA English DT Article DE military; aviation ID FARNSWORTH LANTERN TEST; QUANTIFICATION AB BACKGROUND: Current color vision (CV) tests used for aviation screening in the U.S. Army only provide pass-fail results, and previous studies have shown variable sensitivity and specificity. The purpose of this study was to evaluate seven CV tests to determine an optimal CV test screener that potentially could be implemented by the U.S. Army. METHODS: There were 133 subjects [65 Color Vision Deficits (CVD), 68 Color Vision Normal (CVN)] who performed all of the tests in one setting. CVD and CVN determination was initially assessed with the Oculus anomaloscope. Each test was administered monocularly and according to the test protocol.The main outcome measures were test sensitivity, specificity, and administration time (automated tests). RESULTS: Three of the four Pseudoisochromatic Plate (PIP) tests had a sensitivity/specificity > 0.90 OD/OS, whereas the FALANT tests had a sensitivity/specificity > 0.80 OD/OS. The Cone Contrast Test (CCT) demonstrated sensitivity/specificity > 0.90 OD/OS, whereas the Color Assessment and Diagnosis (CAD) test demonstrated sensitivity/specificity > 0.85 OD/OS. Comparison with the anomaloscope ("gold standard") revealed no significant difference of sensitivity and specificity OD/OS with the CCT, Dvorine PIP, and PIPC tests. Finally, the CCT administration time was significantly faster than the CAD test. DISCUSSION: The current U.S. Army CV screening tests demonstrated good sensitivity and specificity, as did the automated tests. In addition, some current PIP tests (Dvorine, PIPC), and the CCT performed no worse statistically than the anomaloscope with regard to sensitivity/specificity. The CCT letter presentation is randomized and results would not be confounded by potential memorization, or fading, of book plates. C1 [Walsh, David V.] US Army, Vis Protect & Performance Div, Aeromed Res Lab, 6901 Farrel Rd, Ft Rucker, AL 36362 USA. Carl R Darnall Army Med Ctr, Optometry Clin, Ft Hood, TX USA. Womack Army Med Ctr, Dept Optometry, Ft Bragg, NC USA. RP Walsh, DV (reprint author), US Army, Vis Protect & Performance Div, Aeromed Res Lab, 6901 Farrel Rd, Ft Rucker, AL 36362 USA. EM david.v.walsh.mil@mail.mil FU Postgraduate Research Participation Program at the U. S. Army Aeromedical Research Laboratory FX This research was sponsored in part by the Postgraduate Research Participation Program at the U. S. Army Aeromedical Research Laboratory administered by the Oak Ridge Institute of Science and Education through an interagency agreement with the U.S. Department of Energy and USAMRMC. NR 18 TC 0 Z9 0 U1 0 U2 0 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 2375-6314 EI 2375-6322 J9 AEROSP MED HUM PERF JI Aerosp. Med.Hum. Perform. PD APR PY 2016 VL 87 IS 4 BP 382 EP 387 DI 10.3357/AMHP.4391.2016 PG 6 WC Biophysics; Public, Environmental & Occupational Health; Medicine, Research & Experimental SC Biophysics; Public, Environmental & Occupational Health; Research & Experimental Medicine GA DH4RA UT WOS:000372771900005 PM 27026122 ER PT J AU Eastwood, G Loaiza, JR Pongsiri, MJ Sanjur, OI Pecor, JE Auguste, AJ Kramer, LD AF Eastwood, Gillian Loaiza, Jose R. Pongsiri, Montira J. Sanjur, Oris I. Pecor, James E. Auguste, Albert J. Kramer, Laura D. TI Enzootic Arbovirus Surveillance in Forest Habitat and Phylogenetic Characterization of Novel Isolates of Gamboa Virus in Panama SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID VENEZUELAN EQUINE ENCEPHALITIS; AEDEOMYIA-SQUAMIPENNIS; YELLOW-FEVER; MOSQUITOS DIPTERA; CULICIDAE; AMERICA; IDENTIFICATION; BUNYAVIRUSES; TRANSMISSION; DIVERSITY AB Landscape changes occurring in Panama, a country whose geographic location and climate have historically supported arbovirus transmission, prompted the hypothesis that arbovirus prevalence increases with degradation of tropical forest habitats. Investigations at four variably degraded sites revealed a diverse array of potential mosquito vectors, several of which are known vectors of arbovirus pathogens. Overall, 675 pools consisting of 25,787 mosquitoes and representing 29 species from nine genera (collected at ground and canopy height across all habitats) were screened for cytopathic viruses on Vero cells. We detected four isolates of Gamboa virus (family: Bunyaviridae; genus: Ortho-bunyavirus) from pools of Aedeomyia squamipennis captured at canopy level in November 2012. Phylogenetic characterization of complete genome sequences shows the new isolates to be closely related to each other with strong evidence of reassortment among the M segment of Panamanian Gamboa isolates and several other viruses of this group. At the site yielding viruses, Soberania National Park in central Panama, 18 mosquito species were identified, and the predominant taxa included A. squamipennis, Coquillettidia nigricans, and Mansonia titillans. C1 [Eastwood, Gillian; Kramer, Laura D.] New York State Dept Hlth, Wadsworth Ctr, Slingerlands, NY USA. [Loaiza, Jose R.] Inst Invest Cient & Serv Alta Tecnol INDICASAT, Ciudad Del Saber, Panama. [Pongsiri, Montira J.] US EPA, Washington, DC 20460 USA. Smithsonian Trop Res Inst, Panama City, Panama. Walter Reed Biosystemat Unit, Suitland, MD USA. [Auguste, Albert J.] Univ Texas Med Branch, Dept Pathol, Keiller Bldg, Galveston, TX 77555 USA. [Sanjur, Oris I.] Smithsonian Trop Res Inst, Mol Biol & Evolut Labs, Ancon, Panama. [Pecor, James E.] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Dept Entomol, Washington, DC 20307 USA. RP Eastwood, G (reprint author), Univ Texas Med Branch, Dept Pathol, Keiller Bldg, Galveston, TX 77555 USA. EM gieastwo@utmb.edu; jloaiza@indicasat.org.pa; pongsiri.montira@epa.gov; sanjuro@si.edu; pecorj@si.edu; ajlaugus@utmb.edu; laura.kramer@health.ny.gov FU Robert E. Shope International Fellowship Award - American Society of Tropical Medicine and Hygiene; James W. McLaughlin Endowment fund; National Research Investigator Board (SNI) of the Secretariat for Science, Technology and Innovation of Panama (SENACYT); U.S. Environmental Protection Agency [DW33-92296801-0] FX Funding for this project was provided via the Robert E. Shope International Fellowship Award granted by the American Society of Tropical Medicine and Hygiene to Gillian Eastwood in 2012. Gillian Eastwood and Albert J. Auguste are also funded by the James W. McLaughlin Endowment fund. Jose R. Loaiza is funded by the National Research Investigator Board (SNI) of the Secretariat for Science, Technology and Innovation of Panama (SENACYT). The U.S. Environmental Protection Agency project "Mosquito Species Diversity and Landscape Change DW33-92296801-0" awarded to Montira Pongsiri covered the costs of mosquito sampling at Las Pavas, Achiote, and Barro Colorado Island, and some of the laboratory supplies and reagents used at NYSDOH. NR 45 TC 0 Z9 0 U1 3 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD APR PY 2016 VL 94 IS 4 BP 786 EP 793 DI 10.4269/ajtmh.15-0445 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA DI1FQ UT WOS:000373242400015 PM 26834200 ER PT J AU Larson, GJ Menzies, J Lawson, DE Evenson, EB Hopkins, NR AF Larson, Grahame J. Menzies, John Lawson, Daniel E. Evenson, Edward B. Hopkins, Nathan R. TI Macro- and micro-sedimentology of a modern melt-out till - Matanuska Glacier, Alaska, USA SO BOREAS LA English DT Article ID LAURENTIDE ICE-SHEET; RICH BASAL ICE; FREEZE-ON MECHANISM; SUBGLACIAL TILL; DEPOSITIONAL PROCESSES; SOUTHEAST ICELAND; CENTRAL POLAND; END MORAINES; DEFORMATION; SEDIMENTATION AB The macro- and micro-sedimentology of a supraglacial melt-out till forming at the Matanuska Glacier was examined in relationship to the properties of the stratified basal zone ice and debris from which it is originating. In situ melting of the basal ice has produced a laminated to bedded diamicton consisting mainly of silt. Macroscopic properties include: discontinuous laminae and beds; lenses of sand, silt aggregates and open-work gravel; deformed and elongate clasts of clay; widely dispersed pebbles and cobbles, those that are prolate usually with their long axes subparallel to parallel to the bedding. Evidence for deformation is absent except for localized bending of beds over or under rock clasts. Microscopic properties are a unique element of this work and include: discontinuous lineations; silt to granule size laminae; prolate coarse sand and rock fragments commonly with their long axis subparallel to bedding; subangular to subrounded irregular shaped clay clasts often appearing as bands; sorted and unsorted silt to granule size horizons, sometimes disrupted by pore-water pathways. Limited deformation occurs around rock clasts and thicker parts of lamina. This study shows that insitu melting of debris-rich basal ice can produce a laminated and bedded diamicton that inherits and thereby preserves stratified basal ice properties. Production and preservation of supraglacial melt-out till require insitu melting of a stagnant, debris-rich basal ice source with a low relief surface that becomes buried by a thick, stable, insulating cover of ice-marginal sediment. Also required are a slow melt rate and adequate drainage to minimize pore-water pressures in the till and overlying sediment cover to maintain stability and uninterrupted deposition. Many modern and ancient hummocky moraines down glacier of subglacial overdeepenings probably meet these process criteria and their common occurrence suggests that both modern and pre-modern supraglacial melt-out tills may be more common than previously thought. C1 [Larson, Grahame J.] Michigan State Univ, Dept Geol Sci, E Lansing, MI 48823 USA. [Menzies, John] Brock Univ, Dept Earth Sci, St Catharines, ON L2S 3A1, Canada. [Lawson, Daniel E.] ERDC Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Evenson, Edward B.; Hopkins, Nathan R.] Lehigh Univ, Dept Earth & Environm Sci, Bethlehem, PA 18015 USA. RP Larson, GJ (reprint author), Michigan State Univ, Dept Geol Sci, E Lansing, MI 48823 USA. EM larsong@msu.edu FU NSF [OPP 9530757] FX The authors wish to thank Bill Stevenson of Glacier Park Resort for his years of logistical support and service as our pilot. The authors also wish to thank Marty Ouellette for the production of thin sections and Mike Lozon for his excellent draughtsmanship. The fieldwork was supported by NSF Grant OPP 9530757 to Evenson, Larson and Lawson. We thank Jonathan Lee of the British Geological Survey and an anonymous reviewer for their comments and criticism that led to improvements in our manuscript. NR 108 TC 0 Z9 0 U1 3 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0300-9483 EI 1502-3885 J9 BOREAS JI Boreas PD APR PY 2016 VL 45 IS 2 BP 235 EP 251 DI 10.1111/bor.12149 PG 17 WC Geography, Physical; Geosciences, Multidisciplinary SC Physical Geography; Geology GA DH7ZJ UT WOS:000373012500004 ER PT J AU Piccirillo, AL Packnett, ER Cowan, DN Boivin, MR AF Piccirillo, Amanda L. Packnett, Elizabeth R. Cowan, David N. Boivin, Michael R. TI Risk factors for disability discharge in enlisted active duty Army soldiers SO DISABILITY AND HEALTH JOURNAL LA English DT Article DE Disability evaluation; Military personnel; Army personnel; Screening ID US ARMY; MARINE CORPS; TEMPORAL TRENDS; UNITED-STATES; U.S. ARMY; RETIREMENT; MILITARY; ADULTS; EPIDEMIOLOGY; PERSONNEL AB Background: The rate of permanent disability retirement in U.S. Army soldiers and the prevalence of combat-related disabilities have significantly increased over time. Prior research on risk factors associated with disability retirement included soldiers retired prior to conflicts in Iraq and Afghanistan. Objective: To identify risk factors for disability discharge among soldiers enlisted in the U.S. Army during military operations in Iraq and Afghanistan. Methods: In this case-control study, cases included active duty soldiers evaluated for disability discharge. Controls, randomly selected from soldiers with no history of disability evaluation, were matched to cases based on enlistment year and sex. Conditional logistic regression models calculated odds of disability discharge. Attributable fractions estimated burden of disability for specific pre-existing condition categories. Poisson regression models compared risk of disability discharge related to common disability types by deployment and combat status. Results: Characteristics at military enlistment with increased odds of disability discharge included a pre-existing condition, increased age or body mass index, white race, and being divorced. Musculoskeletal conditions and overweight contributed the largest proportion of disabilities. Deployment was protective against disability discharge or receiving a musculoskeletal-related disability, but significantly increased the risk of disability related to a psychiatric or neurological condition. Conclusions: Soldiers with a pre-existing condition at enlistment, particularly a musculoskeletal condition, had increased odds of disability discharge. Risk of disability was dependent on condition category when stratified by deployment and combat status. Additional research examining conditions during pre-disability hospitalizations could provide insight on specific conditions that commonly lead to disability discharge. (c) 2016 Elsevier Inc. All rights reserved. C1 [Piccirillo, Amanda L.; Packnett, Elizabeth R.; Cowan, David N.; Boivin, Michael R.] Walter Reed Army Inst Res, Prevent Med Branch, Dept Epidemiol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. [Piccirillo, Amanda L.; Packnett, Elizabeth R.; Cowan, David N.] ManTech Int Corp, ManTech Hlth, 13755 Sunrise Valley Dr,Suite 500, Herndon, VA 20171 USA. RP Boivin, MR (reprint author), Walter Reed Army Inst Res, Prevent Med Branch, Dept Epidemiol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM michael.r.boivin2.mil@mail.mil FU Defense Health Program FX This study was supported by funds provided by the Defense Health Program. This funding source had no additional involvement in any stage of this study. NR 23 TC 0 Z9 0 U1 1 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1936-6574 EI 1876-7583 J9 DISABIL HEALTH J JI Disabil. Health J. PD APR PY 2016 VL 9 IS 2 BP 324 EP 331 DI 10.1016/j.dhjo.2015.11.005 PG 8 WC Health Care Sciences & Services; Health Policy & Services; Public, Environmental & Occupational Health; Rehabilitation SC Health Care Sciences & Services; Public, Environmental & Occupational Health; Rehabilitation GA DH3WT UT WOS:000372718200022 PM 26905973 ER PT J AU Dar, RA Giri, L Karna, SP Srivastava, AK AF Dar, Riyaz A. Giri, Lily Karna, Shashi P. Srivastava, Ashwini K. TI Performance of palladium nanoparticle-graphene composite as an efficient electrode material for electrochemical double layer capacitors SO ELECTROCHIMICA ACTA LA English DT Article DE Graphene; Palladium nanoparticles; Supercapacitors; Energy density ID ENERGY-STORAGE PROPERTIES; GRAPHITE OXIDE; SUPERCAPACITOR ELECTRODES; NANOSTRUCTURED MATERIALS; RAMAN-SPECTROSCOPY; FACILE SYNTHESIS; CARBON MATERIALS; NANOSHEETS; REDUCTION; SHEETS AB Palladium nanoparticle-graphene nanosheet composite (PdNP-GN) is demonstrated as an efficient electrode material in energy storage applications in supercapacitors. Palladium nanoparticle (PdNP) decorated graphene nanosheet (GN) composite was synthesized via a chemical approach in a single step by the simultaneous reduction of graphene oxide (GO) and palladium chloride from the aqueous phase using ascorbic acid as reducing agent. The materials were characterized by scanning and high resolution transmission electron microscopy, Raman, X-ray diffraction and energy dispersive X-ray spectroscopy which demonstrate that the metal nanoparticles have been uniformly deposited on the surface of graphene nanosheets. The synthesized material has been analyzed by cyclic voltammetry, electrochemical impedance spectrometry and chronopotentiometry using 1 M KCl as the supporting electrolyte for its application in electrochemical double layer supercapacitors. PdNPs-GN composite showed improved electron transfer kinetics and superior capacitive performance with large specific capacitance of 637 F g (1), excellent cyclic performance and maximum energy and power densities of 56 Wh kg (1) and 1166 W kg (1), respectively at a current density of 1.25 A g (1). This highlights the importance of the synergetic effects of electrochemically efficient Pd nanoparticles and graphene for energy storage applications in supercapacitors. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Dar, Riyaz A.; Srivastava, Ashwini K.] Univ Bombay, Dept Chem, Bombay 400098, Maharashtra, India. [Giri, Lily; Karna, Shashi P.] US Army Res Lab, Weap & Mat Res Lab, RDRL WM, Aberdeen Proving Ground, MD 21005 USA. [Dar, Riyaz A.] Maharashtra Coll Arts Sci & Commerce, Dept Chem, Bombay 400008, Maharashtra, India. RP Srivastava, AK (reprint author), Univ Bombay, Dept Chem, Bombay 400098, Maharashtra, India. EM aksrivastava@chem.mu.ac.in FU University Grants Commission, New Delhi, India; Research Participation Program at the U.S. Army Research Laboratory (US ARL) FX The authors are thankful to University Grants Commission, New Delhi, India for financial assistance under its Dr. D. S. Kothari Post doctorate fellowship scheme (RAD). This research by one of us (L. G.) was supported in part by an appointment to the Research Participation Program at the U.S. Army Research Laboratory (US ARL) administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and US ARL. NR 62 TC 3 Z9 3 U1 17 U2 45 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0013-4686 EI 1873-3859 J9 ELECTROCHIM ACTA JI Electrochim. Acta PD APR 1 PY 2016 VL 196 BP 547 EP 557 DI 10.1016/j.electacta.2016.02.197 PG 11 WC Electrochemistry SC Electrochemistry GA DH6CA UT WOS:000372877400059 ER PT J AU Dos Santos, RF Shah, S Boedihardjo, A Chen, F Lu, CT Butler, P Ramakrishnan, N AF Dos Santos, Raimundo F., Jr. Shah, Sumit Boedihardjo, Arnold Chen, Feng Lu, Chang-Tien Butler, Patrick Ramakrishnan, Naren TI A framework for intelligence analysis using spatio-temporal storytelling SO GEOINFORMATICA LA English DT Article DE Spatial-temporal systems; Entity relationship modeling; Social media networks; Spatial and physical reasoning; Semantic networks AB Social media have ushered in alternative modalities to propagate news and developments rapidly. Just as traditional IR matured to modeling storylines from search results, we are now at a point to study how stories organize and evolve in additional mediums such as Twitter, a new frontier for intelligence analysis. This study takes as input news articles as well as social media feeds and extracts and connects entities into interesting storylines not explicitly stated in the underlying data. First, it proposes a novel method of spatio-temporal analysis on induced concept graphs that models storylines propagating through spatial regions in a time sequence. Second, it describes a method to control search space complexity by providing regions of exploration. And third, it describes ConceptRank as a ranking strategy that differentiates strongly-typed connections from weakly-bound ones. Extensive experiments on the Boston Marathon Bombings of April 15, 2013 as well as socio-political and medical events in Latin America, the Middle East, and the United States demonstrate storytelling's high application potential, showcasing its use in event summarization and association analysis that identifies events before they hit the newswire. C1 S Army Corps Engn Geospatial Res Lab, Alexandria, VA USA. Virginia Tech Comp Sci Dept, Falls Church, VA 22043 USA. State Univ New York SUNY, Albany, NY USA. [Dos Santos, Raimundo F., Jr.; Boedihardjo, Arnold] US Army, Corps Engineers Geospatial Res Lab, Alexandria, VA USA. [Shah, Sumit; Lu, Chang-Tien; Butler, Patrick; Ramakrishnan, Naren] Virginia Tech, Dept Comp Sci, 7054 Haycock Rd, Falls Church, VA 22043 USA. [Chen, Feng] SUNY Albany, Albany, NY 12222 USA. RP Dos Santos, RF (reprint author), US Army, Corps Engineers Geospatial Res Lab, Alexandria, VA USA. EM rdossant@vt.edu; sshah@vt.edu; arnold.p.boedihardjo@usace.army.mil; fchen5@albany.edu; ctlu@vt.edu; pabutler@vt.edu; naren@vt.edu OI Dos Santos, Ray/0000-0001-6495-803X NR 29 TC 0 Z9 0 U1 3 U2 13 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1384-6175 EI 1573-7624 J9 GEOINFORMATICA JI Geoinformatica PD APR PY 2016 VL 20 IS 2 BP 285 EP 326 DI 10.1007/s10707-015-0236-8 PG 42 WC Computer Science, Information Systems; Geography, Physical SC Computer Science; Physical Geography GA DH9YR UT WOS:000373152400006 ER PT J AU Song, SA Tolisano, AM Cable, BB Camacho, M AF Song, Sungjin A. Tolisano, Anthony M. Cable, Benjamin B. Camacho, Macario TI Neurocognitive outcomes after pediatric adenotonsillectomy for obstructive sleep apnea: A systematic review and meta-analysis SO INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY LA English DT Review DE Tonsillectomy; Adenotonsillectomy; Neurocognitive; Systematic review; Meta-analysis ID QUALITY-OF-LIFE; CLINICAL-PRACTICE GUIDELINE; CHILDREN; BEHAVIOR; TONSILLECTOMY; COGNITION; IMPACT; ADENOIDECTOMY; PERFORMANCE; DEFICITS AB Objective: To provide an up-to-date systematic review and critical appraisal of prospectively performed studies evaluating neurocognitive function in children treated with adenotonsillectomy. Data sources: PubMed/MEDLINE, Scopus, Web of Science, and the Cochrane Library. Review methods: Searches were performed from inception through September 2, 2015. Results: Nineteen prospective studies (898 adenotonsillectomy patients) met criteria and reported neurocognitive outcomes. The average age of children was 6.6 +/- 2.3 years (range 2.5-14 years) and 51.1% were male. Pre- and post-operative data utilizing the Neuropsychological Developmental Assessment score demonstrated an increase from a means + standard deviations of 101.5 +/- 14.7 [95% CI 100.0, 103.0] to 108.8 +/- 13.4 [95% CI 107.4, 110.2], p-value <0.0001 (375 children, three studies). Pre- and post-operative data utilizing the Stanford-Binet Intelligence Scales (IQ) demonstrated an increase in IQ scores from a means standard deviations of 97.1 +/- 13.8 [95% CI 91.6, 95.4] to 100.7 +/- 11.1 [95% CI 100.4,103.4], p-value <0.0001 (254 children, three studies). The mean pre- and post-adenotonsillectomy apnea-hypopnea index (AHI) decreased from 8.0 to 1.8 (274 children, six studies). Conclusions: This meta-analysis found an improvement in neurocognitive function and IQafter pediatric adenotonsillectomy, especially in pre-school aged children. However, this must be interpreted with caution as only three studies were performed in pre-school aged children. The decreased effectiveness in older children suggests possibly a threshold age when neurocognitive deficits become irreversible. Published by Elsevier Ireland Ltd. C1 [Song, Sungjin A.; Tolisano, Anthony M.; Cable, Benjamin B.; Camacho, Macario] Tripler Army Med Ctr, Dept Otolaryngol Head & Neck Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. [Camacho, Macario] Stanford Hosp & Clin, Dept Psychiat & Behav Sci, Sleep Med Div, Stanford, CA USA. RP Song, SA (reprint author), Tripler Army Med Ctr, Dept Otolaryngol Head & Neck Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM Sungjin.a.song.mil@mail.mil NR 36 TC 1 Z9 1 U1 1 U2 1 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0165-5876 EI 1872-8464 J9 INT J PEDIATR OTORHI JI Int. J. Pediatr. Otorhinolaryngol. PD APR PY 2016 VL 83 IS 4 BP 205 EP 210 DI 10.1016/j.ijporl.2016.02.011 PG 6 WC Otorhinolaryngology; Pediatrics SC Otorhinolaryngology; Pediatrics GA DH6ZX UT WOS:000372941700037 PM 26968078 ER PT J AU Bastian, ND Boguchwal, L Langhans, Z Evans, D AF Bastian, Nathaniel D. Boguchwal, Louis Langhans, Zachary Evans, Daniel TI A multi-criteria, network analytic approach to war game participant selection SO JOURNAL OF DEFENSE MODELING AND SIMULATION-APPLICATIONS METHODOLOGY TECHNOLOGY-JDMS LA English DT Article DE Multiple criteria decision analysis; network analytics; team selection; structural equivalence; war game ID KNOWLEDGE ACQUISITION AB A critical component of the military war game planning process is selecting who should participate, as these participants heavily influence war game outcomes. These outcomes directly impact both strategic and operational decision-making and defense planning, shaping both future defense policy and budget. In this paper, we propose a novel team selection algorithm and decision-support tool combining methods from multiple criteria decision analysis and network analytics to select and visualize a group of war game participants. This method accounts for the diverse requirements of the decision-maker. The results are not only applicable to war games, but also to any team selection domain, such as employee hiring and college admissions. C1 [Bastian, Nathaniel D.] Penn State Univ, Dept Ind & Mfg Engn, University Pk, PA 16802 USA. [Bastian, Nathaniel D.; Boguchwal, Louis; Langhans, Zachary; Evans, Daniel] US Mil Acad, Dept Math Sci, Network Sci Ctr, West Point, NY USA. RP Bastian, ND (reprint author), Penn State Univ, 355 Leonhard Bldg, University Pk, PA 16802 USA. EM ndbastian@psu.edu NR 15 TC 0 Z9 0 U1 0 U2 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1548-5129 EI 1557-380X J9 J DEF MODEL SIMUL-AP JI J. Def. Model. Simul.-Appl. Methodol. Technol.-JDMS PD APR PY 2016 VL 13 IS 2 BP 183 EP 194 DI 10.1177/1548512915586883 PG 12 WC Engineering, Multidisciplinary SC Engineering GA DI3GP UT WOS:000373387200005 ER PT J AU Reed, GS Petty, MD Jones, NJ Morris, AW Ballenger, JP Delugach, HS AF Reed, Gregory S. Petty, Mikel D. Jones, Nicholaos J. Morris, Anthony W. Ballenger, John P. Delugach, Harry S. TI A principles-based model of ethical considerations in military decision making SO JOURNAL OF DEFENSE MODELING AND SIMULATION-APPLICATIONS METHODOLOGY TECHNOLOGY-JDMS LA English DT Article DE Human behavior modeling; decision analysis; machine ethics; modeling and simulation ID LINEAR-MODELS; EVIL AB When comparing alternative courses of action, modern military decision makers often must consider both the military effectiveness and the ethical consequences of the available alternatives. The basis, design, calibration, and performance of a principles-based computational model of ethical considerations in military decision making are reported in this article. The relative ethical violation (REV) model comparatively evaluates alternative military actions based upon the degree to which they violate contextually relevant ethical principles. It is based on a set of specific ethical principles deemed by philosophers and ethicists to be relevant to military courses of action. A survey of expert and non-expert human decision makers regarding the relative ethical violation of alternative actions for a set of specially designed calibration scenarios was conducted to collect data that was used to calibrate the REV model. Perhaps unsurprisingly, the survey showed that people, even experts, disagreed greatly amongst themselves regarding the scenarios' ethical considerations. Despite this disagreement, two significant results emerged. First, after calibration the REV model performed very well in terms of replicating the ethical assessments of human experts for the calibration scenarios. The REV model outperformed an earlier model that was based on tangible consequences rather than ethical principles, that earlier model performed comparably to human experts, the experts outperformed human non-experts, and the non-experts outperformed random selection of actions. All of these performance comparisons were measured quantitatively and confirmed with suitable statistical tests. Second, although humans tended to value some principles over others, none of the ethical principles involvedeven the principle of not harming civilianscompletely overshadowed all of the other principles. C1 [Reed, Gregory S.; Petty, Mikel D.; Jones, Nicholaos J.; Ballenger, John P.; Delugach, Harry S.] Univ Alabama, Shelby Ctr 142,301 Sparkman Dr, Huntsville, AL 35899 USA. [Morris, Anthony W.] Army Res Lab, AMCOM Field Element, Redstone Arsenal, AL USA. RP Reed, GS (reprint author), Univ Alabama, Shelby Ctr 142,301 Sparkman Dr, Huntsville, AL 35899 USA. EM gregory.reed@uah.edu OI Jones, Nicholaos/0000-0003-4928-5089 NR 31 TC 0 Z9 0 U1 2 U2 3 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1548-5129 EI 1557-380X J9 J DEF MODEL SIMUL-AP JI J. Def. Model. Simul.-Appl. Methodol. Technol.-JDMS PD APR PY 2016 VL 13 IS 2 BP 195 EP 211 DI 10.1177/1548512915581213 PG 17 WC Engineering, Multidisciplinary SC Engineering GA DI3GP UT WOS:000373387200006 ER PT J AU Cassenti, DN AF Cassenti, Daniel N. TI A robotics operator manager role for military application SO JOURNAL OF DEFENSE MODELING AND SIMULATION-APPLICATIONS METHODOLOGY TECHNOLOGY-JDMS LA English DT Article DE Robotics; network science; cognitive modeling; decision making AB Due to the increasing use of robots in US military operations, a new role may help to manage and coordinate multiple robotic assets, especially when considering the high mental workload requirements for robot control. The role of a robotics operator manager (ROM) was formed to study a path forward in solving this problem. An experiment with human test participants acting as ROMs showed that the ROM role as constructed is a workable solution to the robot management problems and also showed that time limits and bandwidth limitation affected engineered explosive detection performance, assessments of trust, and ratings of mental workload. Some of these results and others showing preferences for image stimuli and ground robots were simulated in an Adaptive Control of Thought-Rational model of the ROM experiment. The experimental and model results reveal that the ROM is not just a workable solution to the robot coordination problem, but that it may also be a preferred solution. I conclude with notes on how to field the role with personnel of specific skill sets. C1 [Cassenti, Daniel N.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Cassenti, DN (reprint author), US Army, Res Lab, RDRL HRS E, Aberdeen Proving Ground, MD 21005 USA. EM daniel.n.cassenti.civ@mail.mil NR 19 TC 0 Z9 0 U1 3 U2 5 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1548-5129 EI 1557-380X J9 J DEF MODEL SIMUL-AP JI J. Def. Model. Simul.-Appl. Methodol. Technol.-JDMS PD APR PY 2016 VL 13 IS 2 BP 227 EP 237 DI 10.1177/1548512916630178 PG 11 WC Engineering, Multidisciplinary SC Engineering GA DI3GP UT WOS:000373387200008 ER PT J AU Britt, TW Crane, M Hodson, SE Adler, AB AF Britt, Thomas W. Crane, Monique Hodson, Stephanie E. Adler, Amy B. TI Effective and Ineffective Coping Strategies in a Low-Autonomy Work Environment SO JOURNAL OF OCCUPATIONAL HEALTH PSYCHOLOGY LA English DT Article DE stressors; coping; mental health; low job control; acceptance ID COVARIANCE STRUCTURE-ANALYSIS; ADULT INTIMATE-RELATIONSHIPS; MENTAL-HEALTH PROBLEMS; THEORETICAL PERSPECTIVE; JOB-SATISFACTION; TEST STATISTICS; SELF-REPORT; STRESS; PERFORMANCE; SUPPORT AB The authors examined the effectiveness of different coping strategies in buffering the negative effects of uncontrollable stressors and predicting mental health symptoms in a low-autonomy work environment using a longitudinal design. Soldiers in training indicated the extent to which they engaged in various coping strategies to deal with stressors related to the training environment at 4 different points in time. Factor analyses of soldiers in 2 different countries (i.e., United States and Australia) yielded 5 coping dimensions: active coping, acceptance of demands, seeking social support, humor, and denial/selfcriticism. Among U.S. soldiers in basic training, acceptance of demands and denial/self-criticism interacted with the magnitude of basic-training stressors to predict mental health symptoms (depression and anxiety) at 3 different points during training while controlling for symptoms at the immediate prior time period. Acceptance buffered soldiers from the negative effects of the stressors, whereas denial/self-criticism exacerbated the effects of the stressors. The results of LGC models also indicated that the slopes of acceptance and active coping were negatively related to the slope of mental health symptoms across training, whereas the slope for denial/self-criticism was positively related to the slope of symptoms. Active coping was less predictive of functioning in the face of stressors and in the prediction of symptoms over time. The results demonstrated that in a low-autonomy occupational setting, acceptance coping was more effective in facilitating good mental health outcomes compared with other coping strategies considered important in prior research (e.g., active coping). C1 [Britt, Thomas W.] Clemson Univ, Dept Psychol, Clemson, SC 29634 USA. [Crane, Monique] Macquarie Univ, Dept Psychol, N Ryde, NSW 2109, Australia. [Hodson, Stephanie E.] Australian Dept Def, Directorate Operat & Strateg Mental Hlth, Canberra, ACT, Australia. [Adler, Amy B.] Walter Reed Army Inst Res, US Army, Med Res Unit Europe, Heidelberg, Germany. [Hodson, Stephanie E.] Dept Vet Affairs, Canberra, ACT, Australia. RP Britt, TW (reprint author), Clemson Univ, Dept Psychol, Clemson, SC 29634 USA. EM twbritt@clemson.edu FU Research Triangle Institute (RTI) FX We thank Michael Wood, Michael Rinehart, Michael Hagan, Tracy Johnson, Victor Martinez, Rachel Eckford, Angela Salvi, Steven Terry, Julie Merrill, Louis Csoka, Tom Powers, Sonya Cable, Stephanie Muraca, and the Research Triangle Institute (RTI) for their research support in the United States; and David Morton, Stephanie Hodson, and Andrew Cohn for their research support in the Australian Defence Force. The views expressed in this article are those of the authors and do not necessarily represent the official policy or position of the U.S. Army Medical Command or the Australian Defence Force. NR 72 TC 1 Z9 1 U1 12 U2 20 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 1076-8998 EI 1939-1307 J9 J OCCUP HEALTH PSYCH JI J. Occup. Health Psychol. PD APR PY 2016 VL 21 IS 2 BP 154 EP 168 DI 10.1037/a0039898 PG 15 WC Public, Environmental & Occupational Health; Psychology, Applied SC Public, Environmental & Occupational Health; Psychology GA DI0XM UT WOS:000373220600003 PM 26641486 ER PT J AU Guevara, C Pirgousis, P Steinberg, B AF Guevara, Carlo Pirgousis, Phillip Steinberg, Barry TI Maxillofacial Gunshot Injuries: A Comparison of Civilian and Military Data SO JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY LA English DT Article ID WOUNDS; MANAGEMENT; FACE AB Purpose: To compare military with civilian gunshot wounds (GSWs) in the maxillofacial region in order to establish differences in presentation, morbidity, and surgical management. Materials and Methods: A cross-sectional study design was used. The University of Florida at Jacksonville oral and maxillofacial surgery operating room census and hospital trauma registry were both reviewed to identify maxillofacial GSW cases from 2005 through 2011. Military GSW data (2005 through 2011) were obtained from the US Department of Defense (DOD). The predictor variables were civilian versus military GSW events. The outcome variables of interest included the region of the face involved, race, gender, death during admission, hospital length of stay, and number of days in the intensive care unit (ICU). Descriptive statistics were computed. Results: The sample was divided into military maxillofacial GSWs (n = 412) and civilian maxillofacial GSWs (n = 287 treated of 2,478 presented). A significant difference was measured between study groups regarding the region of the face involved (P = .0451), gender (P <= .0001), and race (P <= .0001). No significant relationship was measured regarding deaths during admission (P = .6510) for either study group. No standard deviation values for hospital length of stay or number of ICU days were provided by the DOD. The mean hospital length of stay for the military group was within the 95% confidence interval of the civilian group findings (6.0-7.6). The mean number of ICU days for the military group was not within the civilian group's 95% confidence interval (1.9-2.9). Conclusions: These data showed important differences in anatomic location, gender, and race distribution of maxillofacial GSWs between military and civilian populations. Limited analysis of hospital length of stay and number of ICU days might indicate no meaningful difference in hospital length of stay, although there was a statistical difference in the number of ICU days between the 2 populations. Future research comparing surgical strategies in these 2 environments could assist maxillofacial surgeons in providing optimal care to their patients. (C) 2016 American Association of Oral and Maxillofacial Surgeons C1 [Guevara, Carlo; Steinberg, Barry] Univ Florida Hosp, Dept Oral & Maxillofacial Surg, Jacksonville, FL USA. [Pirgousis, Phillip] Univ Florida Hosp, Div Head & Neck Surg, Dept Oral & Maxillofacial Surg, Jacksonville, FL USA. [Steinberg, Barry] US Army Reserve, Joint Special Operat Med Training Ctr, Jacksonville, FL USA. RP Guevara, C (reprint author), 9745 Touchton Rd,Apartment 725, Jacksonville, FL 32246 USA. EM carlo.guevara@jax.ufl.edu NR 11 TC 0 Z9 0 U1 0 U2 2 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0278-2391 EI 1531-5053 J9 J ORAL MAXIL SURG JI J. Oral Maxillofac. Surg. PD APR PY 2016 VL 74 IS 4 AR 795.e1 DI 10.1016/j.joms.2015.11.007 PG 7 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA DH9BI UT WOS:000373090400019 PM 26687155 ER PT J AU Wong, MR Reggio, MJ Morocho, FR Holloway, MM Garcia-Blanco, JC Jenkins, C Johnson, AD AF Wong, Marc R. Reggio, Matt J. Morocho, Freddy R. Holloway, Monica M. Garcia-Blanco, Jose C. Jenkins, Constance Johnson, Arthur D. TI Effects of intraosseous epinephrine in a cardiac arrest swine model SO JOURNAL OF SURGICAL RESEARCH LA English DT Article DE Epinephrine; Intraosseous; Intravenous; Pharmacokinetics; Cardiopulmonary resuscitation; Return of spontaneous circulation ID AMERICAN-HEART-ASSOCIATION; EMERGENCY CARDIOVASCULAR CARE; RANDOMIZED CONTROLLED-TRIAL; CARDIOPULMONARY-RESUSCITATION; VENTRICULAR-FIBRILLATION; CHEST COMPRESSIONS; PERFUSION-PRESSURE; VASCULAR ACCESS; GUIDELINES AB Background: Interruptions in cardiopulmonary resuscitation (CPR) to obtain vascular access reduces blood flow to vital organs. Tibial intraosseous (TIO) access may be a faster alternative to intravenous (IV) access for delivery of vasoactive medications. The purpose of this study was to examine the differences in pharmacokinetics and pharmacodynamics of TIO- and IV-delivered epinephrine. Materials and methods: A prospective, between subjects, experimental design comparing C-max, T-max, return of spontaneous circulation (ROSC), and time to ROSC. Adult male swine were divided into three equal groups (n = 7) all received CPR and defibrillation: the second group received IV epinephrine and the third group received tibial intraosseous epinephrine. Swine were placed in cardiac arrest for 2 min before CPR was initiated. After 2 min of CPR, epinephrine was delivered by IV or TIO, and serial blood samples were collected over 4 min. Results: There were no significant differences between IV versus TIO epinephrine in achieving ROSC, time to ROSC, and C-max. A one-way analysis of variance demonstrated a significant difference between the IV and TIO groups in T-max (P = 0.025). A Fisher exact test demonstrated a significant difference between IV epinephrine versus CPR/Defib only (P = 0.035) and TIO epinephrine versus CPR/Defib only (P = 0.010) in achieving ROSC. A multivariate analysis of variance showed significant differences in IV versus intraosseous epinephrine concentration at specific time intervals: 60 (P = 0.023), 90 (P = 0.001), and 120 (P < 0.000) sec. Conclusions: In the context of ROSC, epinephrine delivered via TIO route is a clinically relevant alternative to IV administration. When IV access cannot be immediately obtained in cardiac arrest patients, TIO access should be considered. Published by Elsevier Inc. C1 [Wong, Marc R.; Reggio, Matt J.; Morocho, Freddy R.; Holloway, Monica M.; Jenkins, Constance; Johnson, Arthur D.] US Army Med Dept Ctr & Sch, Hlth Readiness Ctr Excellence, Grad Sch US Army Grad Program Nursing Anesthesia, JBSA FSH, San Antonio, TX USA. [Garcia-Blanco, Jose C.] Texas Tech Univ, Hlth Sci Ctr El Paso, Dept Internal Med, El Paso, TX USA. RP Johnson, AD (reprint author), US Army Grad Program Nursing Anesthesia, JBSA FSH, Dunlap Hall,BLDG 1394,Rm 118, Ft Sam Houston, TX 78234 USA. EM arthurjohnso@gmail.com FU TriService Nursing Research Program, Bethesda, MD [HU0001-11-1-TS08] FX Research funding for this study (grant number: HU0001-11-1-TS08) was provided by TriService Nursing Research Program, Bethesda, MD. The opinions expressed are those of the authors and are not necessarily representative of those of the US Army Graduate Program in Anesthesia Nursing, the United States Army, or the Department of Defense. The authors have no proprietary or commercial interest in any product mentioned in the article. NR 29 TC 0 Z9 0 U1 1 U2 1 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0022-4804 EI 1095-8673 J9 J SURG RES JI J. Surg. Res. PD APR PY 2016 VL 201 IS 2 BP 327 EP 333 DI 10.1016/j.jss.2015.11.015 PG 7 WC Surgery SC Surgery GA DH8VS UT WOS:000373075600013 PM 27020815 ER PT J AU Torres, I Nguyen, NM Jivani, R Terner, J Romfh, P Vakhshoori, D Ward, KR AF Torres Filho, Ivo Nguyen, Nguyen M. Jivani, Rizwan Terner, James Romfh, Padraic Vakhshoori, Daryoosh Ward, Kevin R. TI Oxygen saturation monitoring using resonance Raman spectroscopy SO JOURNAL OF SURGICAL RESEARCH LA English DT Article DE Oxygen saturation; Raman spectroscopy; Shock; Hemorrhage; Tissue oxygenation ID NEAR-INFRARED SPECTROSCOPY; OPTICAL-PATH LENGTH; TISSUE OXYGENATION; HEMORRHAGIC-SHOCK; MICROCIRCULATION; HEMOGLOBIN; HYPOXIA; IMAGES; VEIN AB Background: The knowledge of hemoglobin oxygen saturation (SO2) and tissue oxygenation is critical to identify the presence of shock and therapeutic options. The resonance vibrational enhancement of hemoglobin allows measurement of oxy- and deoxy species of hemoglobin and resonance Raman spectroscopy (RRS-StO(2)) has been successfully used to measure aggregate microvascular oxygenation. We tested the hypothesis that noninvasive oxygen saturation measured by RRS-StO(2) could serve as surrogate of systemic central venous SO2. Methods: In anesthetized rats, measurements of RRS-StO(2) made in oral mucosa, skin, muscle, and liver were compared with measurements of central venous SO2 using traditional multi-wavelength oximetry. Various oxygenation levels were obtained using a stepwise hemorrhage while over 100 paired blood samples and Raman-based measurements were performed. The relationships between RRS-StO(2) and clinically important systemic blood parameters were also evaluated. RRS-StO(2) measurements were made in 3-mm diameter tissue areas using a microvascular oximeter and a handheld probe. Results: Significant correlations were found between venous SO2 and RRS-StO(2) measurements made in the oral mucosa (r = 0.913, P < 0.001), skin (r = 0.499, P < 0.01), and liver (r = 0.611, P < 0.05). The mean difference between sublingual RRS-StO(2) and blood sample SO2 values was 5.4 +/- 1.6%. Sublingual RRS-StO(2) also correlated with lactate (r = 0.909, P < 0.01), potassium (r = 0.757, P < 0.01), and pH (r = 0.703, P < 0.05). Conclusions: Raman-based oxygen saturation is a promising technique for the noninvasive evaluation of oxygenation in skin, thin tissues, and solid organs. Under certain conditions, sublingual RRS-StO(2) measurements correlate with central venous SO2. Published by Elsevier Inc. C1 [Torres Filho, Ivo; Nguyen, Nguyen M.; Jivani, Rizwan] Virginia Commonwealth Univ, Dept Anesthesiol, Richmond, VA USA. [Torres Filho, Ivo; Nguyen, Nguyen M.; Jivani, Rizwan; Terner, James] Virginia Commonwealth Univ, Reanimat Engn Sci Ctr, Richmond, VA USA. [Torres Filho, Ivo] Virginia Commonwealth Univ, Dept Emergency Med, Richmond, VA USA. [Torres Filho, Ivo] US Army Inst Surg Res, Damage Control Resuscitat, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. [Terner, James] Virginia Commonwealth Univ, Dept Chem, Box 2006, Richmond, VA 23284 USA. [Romfh, Padraic; Vakhshoori, Daryoosh] Pendar Med, Cambridge, MA USA. [Ward, Kevin R.] Univ Michigan, Dept Emergency Med, Ann Arbor, MI 48109 USA. [Ward, Kevin R.] Univ Michigan, Michigan Ctr Integrat Res Crit Care, Ann Arbor, MI 48109 USA. RP Torres, I (reprint author), US Army Inst Surg Res, Damage Control Resuscitat, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM ivo.p.torresfilho.civ@mail.mil NR 29 TC 0 Z9 0 U1 4 U2 8 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0022-4804 EI 1095-8673 J9 J SURG RES JI J. Surg. Res. PD APR PY 2016 VL 201 IS 2 BP 425 EP 431 DI 10.1016/j.jss.2015.12.001 PG 7 WC Surgery SC Surgery GA DH8VS UT WOS:000373075600026 ER PT J AU Robinson, JD Vahedifard, F Rais-Rohani, M Mason, GL Priddy, JD AF Robinson, Joe D. Vahedifard, Farshid Rais-Rohani, Masoud Mason, George L. Priddy, Jody D. TI Multi-objective traction optimization of vehicles in loose dry sand using the generalized reduced gradient method SO JOURNAL OF TERRAMECHANICS LA English DT Article DE Mobility; Vehicle terrain interface (VTI) model; Drawbar pull (DBP) coefficient; Work optimum coefficient (WOC); Multi-objective optimization ID TRACKED VEHICLE AB A work optimization strategy is combined with algorithms within the vehicle-terrain interface (VTI) model to maximize the traction of a four-wheel vehicle operating on loose dry sand. The optimization model distributes traction among the steered and non-steered wheels with the work optimum coefficient (WOC) of each wheel treated as an independent design objective. Drawbar pull (DBP), motion resistance (MR), longitudinal traction coefficient (LTC), lateral force coefficient (LFC), tire deflection, and wheel slip are key parameters that appear in the VTI model for traction performance analysis. The analysis includes wheels of different diameters, widths, heights, and inflation pressures, under variable wheel slips. A multi-objective optimization problem is formulated over a thirteen-dimensional search space bounded by eight design constraints. The generalized reduced gradient method is used to predict optimal values of the design variables as well as ground and traction parameters such as DBP, MR, LTC, and LFC for maximum slope climbing efficiency. The WOCs are maximized for lateral slip angles between 0 degrees and 24 degrees to find a set of Pareto optimal solutions over a wide range of weight factors. A method to apply the optimization results for predicting vehicle performance and traction control on dry sand is presented and discussed. (C) 2016 ISTVS. Published by Elsevier Ltd. All rights reserved. C1 [Robinson, Joe D.; Vahedifard, Farshid] Mississippi State Univ, Dept Civil & Environm Engn, Mississippi State, MS 39762 USA. [Robinson, Joe D.; Vahedifard, Farshid; Rais-Rohani, Masoud; Mason, George L.] Mississippi State Univ, Ctr Adv Vehicular Syst, Mississippi State, MS 39762 USA. [Rais-Rohani, Masoud] Mississippi State Univ, Dept Aerosp Engn, Mississippi State, MS 39762 USA. [Priddy, Jody D.] US Army, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. RP Vahedifard, F (reprint author), Mississippi State Univ, Dept Civil & Environm Engn, Mississippi State, MS 39762 USA.; Vahedifard, F (reprint author), Mississippi State Univ, Ctr Adv Vehicular Syst, Mississippi State, MS 39762 USA. EM jdr418@msstate.edu; farshid@cee.msstate.edu; masoud@ae.msstate.edu; George.1.Mason.PE@engineer.com; Jody.D.Priddy@erdc.dren.mil FU U.S. Government [W15QKN-13-9-0001] FX This paper is based upon work sponsored by the U.S. Government under Other Transaction number W15QKN-13-9-0001 between the Consortium for Energy, Environment and Demilitarization, and the Government. The U.S. Government is authorized to reproduce and distribute reprints for Governmental purposes notwithstanding any copyright notation thereon. The views and conclusions contained herein are those of the authors and should not be interpreted as necessarily representing the official policies or endorsements, either expressed or implied, of the U.S. Government. This paper is based on the work conducted under Task 12: Mobility Modeling for Soils. Roger King, Director of the Center for Advanced Vehicular Systems (CAVS) at Mississippi State University, was principal investigator for W15QKN-13-9-0001 and Farshid Vahedifard was the lead for Task 12. NR 39 TC 0 Z9 0 U1 3 U2 9 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4898 EI 1879-1204 J9 J TERRAMECHANICS JI J. Terramech. PD APR PY 2016 VL 64 BP 46 EP 57 DI 10.1016/j.jterra.2015.12.005 PG 12 WC Engineering, Environmental SC Engineering GA DH3IM UT WOS:000372680700005 ER PT J AU Karl, JP Smith, TJ Wilson, MA Bukhari, AS Pasiakos, SM McClung, HL McClung, JP Lieberman, HR AF Karl, J. Philip Smith, Tracey J. Wilson, Marques A. Bukhari, Asma S. Pasiakos, Stefan M. McClung, Holly L. McClung, James P. Lieberman, Harris R. TI Altered metabolic homeostasis is associated with appetite regulation during and following 48-h of severe energy deprivation in adults SO METABOLISM-CLINICAL AND EXPERIMENTAL LA English DT Article DE Energy density; Satiety; Substrate oxidation; Weight loss; Starvation ID DEHYDROEPIANDROSTERONE-SULFATE LEVELS; OBESE ZUCKER RATS; FOOD-INTAKE; PHYSICAL PERFORMANCE; BODY-COMPOSITION; HYPOTHALAMIC NEUROTRANSMITTERS; CARDIOVASCULAR-DISEASE; CONTROLLED-TRIAL; WEIGHT-LOSS; DHEA-S AB Background. Military personnel frequently endure intermittent periods of severe energy deficit which can compromise health and performance. Physiologic factors contributing to underconsumption, and the subsequent drive to overeat, are not fully characterized. This study aimed to identify associations between appetite, metabolic homeostasis and endocrine responses during and following severe, short-term energy deprivation. Methods. Twenty-three young adults (17 M/6 F, 21 +/- 3 years, BMI 25 +/- 3 kg/m(2)) participated in a randomized, controlled, crossover trial. During separate 48-h periods, participants increased habitual energy expenditure by 1647 +/- 345 kcal/d (mean +/- SD) through prescribed exercise at 40-65% VO2peak, and consumed provided isovolumetric diets designed to maintain energy balance at the elevated energy expenditure (EB; 36 +/- 93 kcal/d energy deficit) or to produce a severe energy deficit (ED; 3681 +/- 716 kcal/d energy deficit). Appetite, markers of metabolic homeostasis and endocrine mediators of appetite and substrate availability were periodically measured. Ad libitum energy intake was measured over 36 h following both experimental periods. Results. Appetite increased during ED and was greater than during EB despite maintenance of diet volume (P = 0.004). Ad libitum energy intake was 907 kcal/36 h [95% CI: 321, 1493 kcal/36 h, P = 0.004] higher following ED compared to following EB. Serum beta-hydroxybutyrate, free fatty acids, branched-chain amino acids, dehydroepiandrosterone-sulfate (DHEA-S) and cortisol concentrations were higher (P < 0.001 for all), whereas whole-body protein balance was more negative (P < 0.001), and serum glucose, insulin, and leptin concentrations were lower (P < 0.001 for all) during ED relative to during EB. Cortisol concentrations, but not any other hormone or metabolic substrate, were inversely associated with satiety during EB (R-2 = 0.23, P = 0.04). In contrast, serum glucose and DHEA-S concentrations were inversely associated with satiety during ED (R-2 = 0.68, P < 0.001). No associations between physiologic variables measured during EB and ad libitum energy intake following EB were observed. However, serum leptin and net protein balance measured during ED were inversely associated with ad libitum energy intake following ED (R-2 = 0.48, P = 0.01). Conclusion. These findings suggest that changes in metabolic homeostasis during energy deprivation modulate appetite independent of reductions in diet volume. Following energy deprivation, physiologic signals of adipose and lean tissue loss may drive restoration of energy balance. Clinical trials registration: www.clinicaltrials.gov #NCT01603550. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). C1 [Karl, J. Philip; Smith, Tracey J.; Wilson, Marques A.; Bukhari, Asma S.; Pasiakos, Stefan M.; McClung, Holly L.; McClung, James P.; Lieberman, Harris R.] US Army Res Inst Environm Med, Mil Nutr Div, 10 Gen Greene Ave,Bldg 42, Natick, MA 01760 USA. RP Karl, JP (reprint author), US Army Res Inst Environm Med, 10 Gen Greene Ave,Bldg 42, Natick, MA 01760 USA. EM james.p.karl.civ@mail.mil RI Pasiakos, Stefan/E-6295-2014 OI Pasiakos, Stefan/0000-0002-5378-5820 FU US Army Medical Research and Materiel Command FX This study is funded by US Army Medical Research and Materiel Command. The study sponsor had no role in the study design, in data collection, analysis or interpretation, in writing the report, or in the decision to submit the report for publication. NR 60 TC 2 Z9 2 U1 1 U2 3 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0026-0495 EI 1532-8600 J9 METABOLISM JI Metab.-Clin. Exp. PD APR PY 2016 VL 65 IS 4 BP 416 EP 427 DI 10.1016/j.metabol.2015.11.001 PG 12 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA DH3EU UT WOS:000372671100004 PM 26975533 ER PT J AU Tenan, MS Hackney, AC Griffin, L AF Tenan, Matthew S. Hackney, Anthony C. Griffin, Lisa TI ENTRAINMENT OF VASTUS MEDIALIS COMPLEX ACTIVITY DIFFERS BETWEEN GENDERS SO MUSCLE & NERVE LA English DT Article DE gender differences; knee; menstrual cycle; motor unit; quadriceps; vastus medialis oblique ID PATELLOFEMORAL PAIN SYNDROME; MOTOR UNIT DISCHARGES; OBLIQUE MUSCLE; PHYSIOLOGICAL TREMOR; QUADRICEPS MUSCLES; MENSTRUAL-CYCLE; SYNCHRONIZATION; MODULATION; INCREASES; MECHANISM AB Introduction: That the vastus medialis oblique (VMO) is a functional unit of the vastus medialis (VM) is disputed. Delayed VMO activation predicts patellofemoral pain, which has higher rates in women. Methods: Single MUs and surface electromyogram (EMG) were collected from the VMO and VM of 9 men and 9 women. Men were tested once; women were tested during 5 menstrual phases. Coherence was assessed for motor unit (MU) firings within and between the VM and VMO using multilevel logistic models to determine statistical significance. Results: Compared with women, men have 741% (MU pairs) and 256% (MU-EMG pairs) greater odds of common drive (0-5 HZ) coherent oscillations. MU pairs from the VMO and the dual VM/VMO complex have 228% and 212% greater odds of coherent oscillations in the beta band (15-35 HZ) compared with VM pairs. Conclusions: The VM and VMO are neurologically different muscles; control of the VM complex is sexually dimorphic. C1 [Tenan, Matthew S.; Griffin, Lisa] Univ Texas Austin, Dept Kinesiol & Hlth Educ, Austin, TX 78712 USA. [Tenan, Matthew S.] US Army, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD USA. [Hackney, Anthony C.] Univ N Carolina, Sch Publ Hlth, Dept Nutr, Dept Exercise & Sport Sci, Chapel Hill, NC 21005 USA. RP Tenan, MS (reprint author), Univ Texas Austin, Dept Kinesiol & Hlth Educ, Austin, TX 78712 USA.; Tenan, MS (reprint author), US Army, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD USA. EM matthew.s.tenan.civ@mail.mil NR 35 TC 0 Z9 0 U1 2 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0148-639X EI 1097-4598 J9 MUSCLE NERVE JI Muscle Nerve PD APR PY 2016 VL 53 IS 4 BP 633 EP 640 DI 10.1002/mus.24897 PG 8 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA DI2SG UT WOS:000373348300020 PM 26348648 ER PT J AU Soonwera, M Phasomkusolsil, S AF Soonwera, Mayura Phasomkusolsil, Siriporn TI Effect of Cymbopogon citratus (lemongrass) and Syzygium aromaticum (clove) oils on the morphology and mortality of Aedes aegypti and Anopheles dirus larvae SO PARASITOLOGY RESEARCH LA English DT Article DE Aedes aegypti; Anopheles dirus; Cymbopogon citratus; Syzygium aromaticum; Larvicide; Morphological aberrations ID CULEX-QUINQUEFASCIATUS SAY; CHEMICAL-COMPOSITION; MOSQUITO LARVAE; OVIPOSITION-DETERRENT; LARVICIDAL ACTIVITY; PLANT-EXTRACTS; CULICIDAE; DIPTERA; REPELLENCY; THAILAND AB Cymbopogon citratus (lemongrass) and Syzygium aromaticum (clove) oils were evaluated to determine mortality rates, morphological aberrations, and persistence when used against third and fourth larval instars of Aedes aegypti and Anopheles dirus. The oils were evaluated at 1, 5, and 10 % concentrations in mixtures with soybean oil. Persistence of higher concentrations was measured over a period of 10 days. For Ae. aegypti, both plant oils caused various morphological aberrations to include deformed larvae, incomplete eclosion, white pupae, deformed pupae, dead normal pupae, and incomplete pupal eclosion. All of these aberrations led to larval mortality. In Ae. aegypti larvae, there were no significant differences in mortality at days 1, 5, and 10 or between third and fourth larval instar exposure. In An. dirus, morphological aberrations were rare and S. aromaticum oil was more effective in causing mortality among all larval stages. Both oils were equally effective at producing mortality on days 1, 5, and 10. Both oils had slightly increased LT50 rates from day 1 to day 10. In conclusion, both lemongrass and clove oils have significant effects on the immature stages of Ae. aegypti and An. dirus and could potentially be developed for use as larvicides. C1 [Soonwera, Mayura] King Mongkuts Inst Technol Ladkrabang, Deparment Plant Prod Technol, Fac Agr Technol, Bangkok 10520, Thailand. [Phasomkusolsil, Siriporn] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. RP Phasomkusolsil, S (reprint author), Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. EM siripornp@afrims.org NR 41 TC 0 Z9 0 U1 4 U2 7 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0932-0113 EI 1432-1955 J9 PARASITOL RES JI Parasitol. Res. PD APR PY 2016 VL 115 IS 4 BP 1691 EP 1703 DI 10.1007/s00436-016-4910-z PG 13 WC Parasitology SC Parasitology GA DH6NL UT WOS:000372907300036 PM 26796022 ER PT J AU Solmeyer, N Li, X Quraishi, Q AF Solmeyer, Neal Li, Xiao Quraishi, Qudsia TI High teleportation rates using cold-atom-ensemble-based quantum repeaters with Rydberg blockade SO PHYSICAL REVIEW A LA English DT Article ID SINGLE PHOTONS; LINEAR OPTICS; MEMORY; COMMUNICATION; STATE; QUBITS; PAIRS AB We present a simplified version of a repeater protocol in a cold neutral-atom ensemble with Rydberg excitations optimized for two-node entanglement generation and describe a protocol for quantum teleportation. Our proposal draws from previous proposals [B. Zhao et al., Phys. Rev. A 81, 052329 (2010); Y. Han et al., ibid. 81, 052311 (2010)] that described efficient and robust protocols for long-distance entanglement with many nodes. Using realistic experimental values, we predict an entanglement generation rate of similar to 25 Hz and a teleportation rate of similar to 5Hz. Our predicted rates match the current state-of-the-art experiments for entanglement generation and teleportation between quantum memories. With improved efficiencies we predict entanglement generation and teleportation rates of similar to 7.8 and similar to 3.6 kHz, respectively, representing a two-order-of-magnitude improvement over the currently realized values. Cold-atom ensembles with Rydberg excitations are promising candidates for repeater nodes because collective effects in the ensemble can be used to deterministically generate a long-lived ground-state memory which may be efficiently mapped onto a directionally emitted single photon. C1 [Solmeyer, Neal; Quraishi, Qudsia] Army Res Lab, Quantum Sci Grp, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Li, Xiao] Univ Maryland, Joint Quantum Inst, College Pk, MD 20742 USA. [Li, Xiao] Univ Maryland, Dept Phys, College Pk, MD 20742 USA. RP Solmeyer, N (reprint author), Army Res Lab, Quantum Sci Grp, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. FU Oak Ridge Associated Universities (ORAU) postdoctoral fellowship; Army Research Laboratory [W911NF-14-2-0101] FX We would like to thank S. Rolston and A. Gorshkov for helpful discussions. N.S. acknolwedges support through an Oak Ridge Associated Universities (ORAU) postdoctoral fellowship. This research was supported by the Army Research Laboratory under Contract #W911NF-14-2-0101. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 60 TC 0 Z9 0 U1 7 U2 12 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2469-9926 EI 2469-9934 J9 PHYS REV A JI Phys. Rev. A PD APR 1 PY 2016 VL 93 IS 4 AR 042301 DI 10.1103/PhysRevA.93.042301 PG 14 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA DI0SC UT WOS:000373206300003 ER PT J AU Busby, RR Rodriguez, G Gebhart, DL Yannarell, AC AF Busby, Ryan R. Rodriguez, Giselle Gebhart, Dick L. Yannarell, Anthony C. TI Native Lespedeza species harbor greater non-rhizobial bacterial diversity in root nodules compared to the coexisting invader, L-cuneata SO PLANT AND SOIL LA English DT Article DE Lespedeza; Nodule bacteria; Legume; Plant invasion; Microbial diversity ID EXOTIC PLANT INVASION; ENDOPHYTIC BACTERIA; SOIL BIOTA; GASTROINTESTINAL NEMATODES; SERICEA-LESPEDEZA; BACILLUS STRAINS; NORTH-AMERICA; LEGUME; GROWTH; MUTUALISMS AB Background and Aims Lespedeza cuneata is a non-native invasive legume that alters the soil bacterial community, associates promiscuously with rhizobia, and benefits more from rhizobial interactions compared to coexisting native Lespedeza in North America. We tested the hypothesis that native congeners differ in their nodule bacteria associations compared to L. cuneata. Methods Plots with high L. cuneata invasion, low L. cuneata invasion with native Lespedeza species present, and uninvaded plots where native Lespedeza species existed without L. cuneata were sampled. Nodules were collected from all Lespedeza species present, and Chamaecrista fasciculata, a common native annual legume. Bacterial DNA from nodules was isolated and sequenced. Results Nodule bacterial composition differed significantly between hosts. L. cuneata nodules contained high frequencies of rhizobial DNA and low bacterial diversity, while native Lespedeza nodules contained lower rhizobial frequencies and higher non-rhizobial bacterial diversity. Specific non-rhizobial bacterial groups exhibited strong associations with native legumes and uninvaded sites. Conclusions Significant differences exist in the nodule bacterial composition between native legumes and an introduced congener. The mechanism(s) and ecological importance of these differences remain unknown. These differences in bacterial associations could influence not only the competitive ability of the invader, but recovery of invaded sites as well. C1 [Busby, Ryan R.; Rodriguez, Giselle; Gebhart, Dick L.] US Army, Engn Res & Dev Ctr, 2902 Newmark Dr, Champaign, IL 61822 USA. [Yannarell, Anthony C.] Univ Illinois, Dept Nat Resources & Environm Sci, 1102 S Goodwin Ave, Urbana, IL 61801 USA. RP Busby, RR (reprint author), US Army, Engn Res & Dev Ctr, 2902 Newmark Dr, Champaign, IL 61822 USA. EM ryan.r.busby@usace.army.mil FU United States Army Direct Funded Research Program [A896] FX This research was funded by the United States Army A896 Direct Funded Research Program. NR 54 TC 0 Z9 0 U1 9 U2 17 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0032-079X EI 1573-5036 J9 PLANT SOIL JI Plant Soil PD APR PY 2016 VL 401 IS 1-2 BP 427 EP 436 DI 10.1007/s11104-015-2763-3 PG 10 WC Agronomy; Plant Sciences; Soil Science SC Agriculture; Plant Sciences GA DH7CC UT WOS:000372947800030 ER PT J AU Simmons, M Sun, PF Putnak, R AF Simmons, Monika Sun, Peifang Putnak, Robert TI Recombinant Dengue 2 Virus NS3 Helicase Protein Enhances Antibody and T-Cell Response of Purified Inactivated Vaccine SO PLOS ONE LA English DT Article ID WEST-NILE-VIRUS; IMMUNOLOGICAL-PROPERTIES; NONSTRUCTURAL PROTEINS; STRUCTURAL PROTEINS; HEMORRHAGIC-FEVER; RHESUS MACAQUES; MICE; ENCEPHALITIS; PROTECTION; IMMUNIZATION AB Dengue virus purified inactivated vaccines (PIV) are highly immunogenic and protective over the short term, but may be poor at inducing cell-mediated immune responses and long-term protection. The dengue nonstructural protein 3 (NS3) is considered the main target for T-cell responses during viral infection. The amino (N)-terminal protease and the carboxy (C)-terminal helicase domains of DENV-2 NS3 were expressed in E.coli and analyzed for their immune-potentiating capacity. Mice were immunized with DENV-2 PIV with and without recombinant NS3 protease or NS3 helicase proteins, and NS3 proteins alone on days 0, 14 and 28. The NS3 helicase but not the NS3 protease was effective in inducing T-cell responses quantified by IFN-gamma ELISPOT. In addition, markedly increased total IgG antibody titer against virus antigen was seen in mice immunized with the PIV/NS3 helicase combination in the ELISA, as well as increased neutralizing antibody titer measured by the plaque reduction neutralization test. These results indicate the potential immunogenic properties of the NS3 helicase protein and its use in a dengue vaccine formulation. C1 [Simmons, Monika; Sun, Peifang] Naval Med Res Ctr, Viral & Rickettsial Dis Dept, Silver Spring, MD USA. [Putnak, Robert] Walter Reed Army Inst Res, Div Viral Dis, Silver Spring, MD USA. RP Simmons, M (reprint author), Naval Med Res Ctr, Viral & Rickettsial Dis Dept, Silver Spring, MD USA. EM monika.simmons.civ@mail.mil FU Military Infectious Disease Research Program (MIDRP), U.S. Army Medical Research and Materiel Command, Fort Detrick, MD [A1325] FX This work was funded by a grant from the Military Infectious Disease Research Program (MIDRP), U.S. Army Medical Research and Materiel Command, Fort Detrick, MD, work unit number A1325. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 48 TC 1 Z9 1 U1 1 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD APR 1 PY 2016 VL 11 IS 4 AR e0152811 DI 10.1371/journal.pone.0152811 PG 16 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DI0QF UT WOS:000373201200044 PM 27035715 ER PT J AU Spain, E Groysberg, B AF Spain, Everett Groysberg, Boris TI MAKING EXIT INTERVIEWS COUNT SO HARVARD BUSINESS REVIEW LA English DT Article C1 [Spain, Everett] US Mil Acad, Dept Behav Sci & Leadership, W Point, WA 10996 USA. [Groysberg, Boris] Harvard Univ, Sch Business, Business Adm, Cambridge, MA 02138 USA. RP Spain, E (reprint author), US Mil Acad, Dept Behav Sci & Leadership, W Point, WA 10996 USA. NR 0 TC 0 Z9 0 U1 1 U2 5 PU HARVARD BUSINESS SCHOOL PUBLISHING CORPORATION PI WATERTOWN PA 300 NORTH BEACON STREET, WATERTOWN, MA 02472 USA SN 0017-8012 J9 HARVARD BUS REV JI Harv. Bus. Rev. PD APR PY 2016 VL 94 IS 4 BP 88 EP 95 PG 8 WC Business; Management SC Business & Economics GA DH5VH UT WOS:000372859900013 ER PT J AU Black, SR Howard, JT Chin, PC Starr, AJ AF Black, Sheena R. Howard, Jeffrey T. Chin, Paul C. Starr, Adam J. TI Toward a More Robust Prediction of Pulmonary Embolism in Trauma Patients: A Risk Assessment Model Based on 38,000 Patients SO JOURNAL OF ORTHOPAEDIC TRAUMA LA English DT Article DE deep venous thrombosis; pulmonary embolism; trauma; venous thromboembolism ID MOLECULAR-WEIGHT HEPARIN; DEEP VENOUS THROMBOSIS; VENA-CAVA FILTERS; MEDICAL PATIENTS; MAJOR TRAUMA; THROMBOEMBOLISM PROPHYLAXIS; 1602 EPISODES; DATA-BANK; INJURY; PREVENTION AB Objectives: Pulmonary embolism (PE) is a rare but sometimes fatal complication of trauma. Risk stratification models identify patients at increased risk of PE; however, they are often complex and difficult to use. This research aims to develop a model, based on a large sample of trauma patients, which can be easily and quickly used at the time of admission to predict PE. Methods: This study used trauma registry data from 38,597 trauma patients. Of these, 239 (0.619%) developed a PE. We targeted demographic and injury data, prehospital information, and data on treatments and events during hospitalization. A multivariate binary logistic regression model was developed to predict the odds of developing a PE during hospitalization. The model was developed using a 50% randomly selected development subsample and then tested for accuracy using the remaining 50% validation sample. Results: We found 7 statistically significant predictors of PE, including (1) age [odds ratio (OR) = 1.01; 95% CI, 1.00-1.02; P = 0.05], (2) obesity (OR = 2.54; 95% CI, 1.29-4.99; P < 0.01), (3) injury from motorcycle accident (OR = 2.01; 95% CI, 1.25-3.22; P < 0.01), (4) arrival by helicopter (OR = 2.91; 95% CI, 1.16-7.27; P = 0.02), (5) emergency department admission pulse rate (OR = 1.01; 95% CI, 1.0-1.02; P = 0.06), (6) admission to intensive care unit (OR = 5.03; 95% CI, 3.12-8.12; P < 0.01), and (7) injury location, including thorax (OR = 1.57; 95% CI, 1.04-2.37; P = 0.03), abdomen (OR = 1.56; 95% CI, 1.04-2.33; P = 0.03), and lower extremity injuries (OR = 2.85; 95% CI, 3.12-8.12; P < 0.01). Our model was able to discriminate between predicted and actual PE events with a receiver operating characteristic area under the curve of 0.87. By identifying the top 25% high-risk patients, we were able to predict 80%-84% of pulmonary emboli. Conclusions: This knowledge allows us to focus stronger thromboprophylactic efforts on patients at highest risk. This model can be used to rapidly identify trauma patients at high risk for PE. Level of Evidence: Prognostic Level II. See Instructions for Authors for a complete description of levels of evidence. C1 [Black, Sheena R.; Chin, Paul C.; Starr, Adam J.] Univ Texas SW Med Ctr Dallas, Dept Orthopaed Surg, 5323 Harry Hines Blvd, Dallas, TX 75390 USA. [Howard, Jeffrey T.] US Army Inst Surg Res, Epidemiol & Biostat, San Antonio, TX USA. RP Black, SR (reprint author), Univ Texas SW Med Ctr Dallas, Dept Orthopaed Surg, 5323 Harry Hines Blvd, Dallas, TX 75390 USA. EM sheena.r.black@gmail.com FU Starrframe, LLC; Smith & Nephew Surgical Approaches for Internal Fixation (SAIF) course FX A. J. Starr receives royalty payments from Starrframe, LLC and is a paid speaker for the Smith & Nephew Surgical Approaches for Internal Fixation (SAIF) course. The remaining authors report no conflict of interest. NR 52 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0890-5339 EI 1531-2291 J9 J ORTHOP TRAUMA JI J. Orthop. Trauma PD APR PY 2016 VL 30 IS 4 BP 200 EP 207 DI 10.1097/BOT.0000000000000484 PG 8 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA DG8QG UT WOS:000372348100010 PM 26562582 ER PT J AU Fink, DS Gallaway, MS Tamburrino, MB Liberzon, I Chan, P Cohen, GH Sampson, L Shirley, E Goto, T D'Arcangelo, N Fine, T Reed, PL Calabrese, JR Galea, S AF Fink, David S. Gallaway, M. Shayne Tamburrino, Marijo B. Liberzon, Israel Chan, Philip Cohen, Gregory H. Sampson, Laura Shirley, Edwin Goto, Toyomi D'Arcangelo, Nicole Fine, Thomas Reed, Philip L. Calabrese, Joseph R. Galea, Sandro TI Onset of Alcohol Use Disorders and Comorbid Psychiatric Disorders in a Military Cohort: Are there Critical Periods for Prevention of Alcohol Use Disorders? SO PREVENTION SCIENCE LA English DT Article DE Prevention; Alcohol-related disorders; Mental disorder; Age of onset; Military personnel ID NATIONAL EPIDEMIOLOGIC SURVEY; SUBSTANCE USE DISORDERS; SELF-REPORTED AGE; POSTTRAUMATIC-STRESS-DISORDER; MAJOR DEPRESSIVE DISORDER; MENTAL-HEALTH; ANXIETY DISORDERS; GUARD SOLDIERS; CHILDHOOD ADVERSITIES; OF-ONSET AB Alcohol use disorders (AUD) are commonly comorbid with anxiety and mood disorders; however, a strategy for AUD prevention remains unclear in the presence of three competing etiological models that each recommends different high-risk groups. Therefore, the investigation of the three hypotheses in a characteristically unique cohort is critical to identifying pervasive characteristics of AUD that can inform a universal prevention strategy. The current study evaluated the temporality and onset of comorbid AUD and psychiatric disorders in a representative sample of 528 Ohio Army National Guard soldiers using structured clinical interviews from 2009 to 2012. We examined temporality both statistically and graphically to identify patterns that could inform prevention. General estimating equations with dichotomous predictor variables were used to estimate odds ratios between comorbid psychiatric disorders and AUDs. An annualized rate of 13.5 % persons per year was diagnosed with any AUD between 2010 and 2012. About an equal proportion of participants with comorbid psychiatric disorders and AUD initiated the psychiatric disorder prior to the AUD and half initiated the psychiatric disorder after the AUD. Regardless of onset, however, the majority (80 %) AUD initiated during a short interval between the ages of 16 and 23. Focused primary prevention during this narrow age range (16-23 years) may have the greatest potential to reduce population mental health burden of AUD, irrespective of the sequencing of comorbid psychiatric disorder. C1 [Fink, David S.; Cohen, Gregory H.] Mailman Sch Publ Hlth, Dept Epidemiol, 722 W 168th St,Room 1513, New York, NY 10032 USA. [Gallaway, M. Shayne] US Army Garrison Ansbach, US Army, Subst Abuse Program, Ansbach, Germany. [Tamburrino, Marijo B.; Fine, Thomas] Univ Toledo, Dept Psychiat, 2801 W Bancroft St, Toledo, OH 43606 USA. [Liberzon, Israel] Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA. [Chan, Philip; Shirley, Edwin; Goto, Toyomi; D'Arcangelo, Nicole; Calabrese, Joseph R.] Case Western Reserve Univ, Univ Hosp, Case Med Ctr, Dept Psychiat, Cleveland, OH 44106 USA. [Sampson, Laura; Galea, Sandro] Boston Univ, Sch Publ Hlth, Boston, MA 02215 USA. [Reed, Philip L.] Michigan State Univ, Biomed Res & Informat Ctr, Ann Arbor, MI USA. RP Fink, DS (reprint author), Mailman Sch Publ Hlth, Dept Epidemiol, 722 W 168th St,Room 1513, New York, NY 10032 USA. EM dsf2130@columbia.edu OI Liberzon, Israel/0000-0002-4990-556X; Fink, David/0000-0003-1531-1525 FU Office of the Assistant Secretary of Defense for Health Affairs through the Joint Warfighter Medical Research Program [W81XWH-15-1-0080, W81XWH-07-1-0409, W81XWH-10-1-0579]; US Army Medical Research Acquisition Activity, Chandler Street, Fort Detrick MD; National Institute on Drug Abuse [T32DA031099] FX This work was supported by the Office of the Assistant Secretary of Defense for Health Affairs through the Joint Warfighter Medical Research Program under Award No. W81XWH-15-1-0080, W81XWH-07-1-0409, and W81XWH-10-1-0579 [DSF, MTB, IL, PC, GHC, LS, ES, TG, ND, TF, PLR, JRC, SG]. The US Army Medical Research Acquisition Activity, 820 Chandler Street, Fort Detrick MD 21702-5014 is the awarding and administering acquisition office. Opinions, interpretations, conclusions, and recommendations are those of the author and are not necessarily endorsed by the Department of Defense. This report was supported by National Institute on Drug Abuse grant T32DA031099 [DSF]. The informatics support for this research was provided by the Michigan State University Clinical and Translational Sciences Institute, through its Biomedical Research Informatics Core. NR 46 TC 1 Z9 1 U1 2 U2 4 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1389-4986 EI 1573-6695 J9 PREV SCI JI Prev. Sci. PD APR PY 2016 VL 17 IS 3 BP 347 EP 356 DI 10.1007/s11121-015-0624-1 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA DG7LT UT WOS:000372266500007 PM 26687202 ER PT J AU Merbah, M Onkar, S Grivel, JC Vanpouille, C Biancotto, A Bonar, L Sanders-Buell, E Kijak, G Michael, N Robb, M Kim, JH Tovanabutra, S Chenine, AL AF Merbah, Melanie Onkar, Sayali Grivel, Jean-Charles Vanpouille, Christophe Biancotto, Angelique Bonar, Lydia Sanders-Buell, Eric Kijak, Gustavo Michael, Nelson Robb, Merlin Kim, Jerome H. Tovanabutra, Sodsai Chenine, Agnes-Laurence TI Standardization of a cytometric p24-capture bead-assay for the detection of main HIV-1 subtypes SO JOURNAL OF VIROLOGICAL METHODS LA English DT Article DE HIV-1; p24; Detection; Multi-subtype; Multiplex assay ID CELLS; REPLICATION; SUPPRESSION; INFECTION; PROTEIN; P24 AB The prevailing method to assess HIV-1 replication and infectivity is to measure the production of p24 Gag protein by enzyme-linked immunosorbent assay (ELISA). Since fluorescent bead-based technologies offer a broader dynamic range and higher sensitivity, this study describes a p24 capture Luminex assay capable of detecting HIV-1 subtypes A-D, circulating recombinant forms (CRF) CRF01_AE and CRF02_AG, which together are responsible for over 90% of HIV-1 infections worldwide. The success of the assay lies in the identification and selection of a cross-reactive capture antibody (clone 183-H12-5C). Fifty-six isolates that belonged to six HIV-1 subtypes and CRFs were successfully detected with p-values below 0.021; limits of detection ranging from 3.7 to 3 x 104 pg/ml. The intra- and inter-assay variation gave coefficient of variations below 6 and 14%, respectively. The 183-bead Luminex assay also displayed higher sensitivity of 91% and 98% compared to commercial p24 ELISA and a previously described Luminex assay. The p24 concentrations measured by the 183 bead Luminex assay showed a significant correlation (R=0.92, p < 0.0001) with the data obtained from quantitative real time PCR. This newly developed p24 assay leverages the advantages of the Luminex platform, which include smaller sample volume and simultaneous detection of up to 500 analytes in a single sample, and delivers a valuable tool for the field. (C) 2016 Elsevier B.V. All rights reserved. C1 [Merbah, Melanie; Onkar, Sayali; Bonar, Lydia; Sanders-Buell, Eric; Kijak, Gustavo; Michael, Nelson; Robb, Merlin; Kim, Jerome H.; Tovanabutra, Sodsai; Chenine, Agnes-Laurence] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. [Merbah, Melanie; Onkar, Sayali; Bonar, Lydia; Sanders-Buell, Eric; Kijak, Gustavo; Robb, Merlin; Tovanabutra, Sodsai; Chenine, Agnes-Laurence] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Grivel, Jean-Charles; Vanpouille, Christophe] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Phys Biol, NIH, Bethesda, MD USA. [Biancotto, Angelique] NIH, Ctr Human Immunol Autoimmun & Inflammat, Bldg 10, Bethesda, MD 20892 USA. RP Merbah, M (reprint author), Walter Reed Army Inst Res, MHRP, 503 Robert Grant Ave,Room 2N11, Silver Spring, MD 20910 USA.; Merbah, M (reprint author), Walter Reed Army Inst Res, Henry M Jackson Fdn Adv Mil Med HJF, 503 Robert Grant Ave,Room 2N11, Silver Spring, MD 20910 USA. EM mmerbah@hivresearch.org; sonkar@hivresearch.org; jgrivel@sidra.org; vanpouic@mail.nih.gov; biancoa@nhlbi.nih.gov; lbonar@hivresearch.org; esanders-buell@hivresearch.org; gkijak@hivresearch.org; nmichael@hivresearch.org; mrobb@hivresearch.org; jerome.kim@ivi.int; stovanabutra@hivresearch.org; achenine@hivresearch.org OI Merbah, Melanie/0000-0002-5641-8612 FU Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-11-2-0174]; U.S. Department of Defense (DoD) [W81XWH-11-2-0174] FX This work was supported by a cooperative agreement (W81XWH-11-2-0174) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense (DoD). The views expressed are those of the authors and should not be construed to represent the positions of the United States Departments of the Army, Defense, or Health and Human Services. NR 24 TC 0 Z9 0 U1 1 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-0934 EI 1879-0984 J9 J VIROL METHODS JI J. Virol. Methods PD APR PY 2016 VL 230 BP 45 EP 52 DI 10.1016/j.jviromet.2016.01.009 PG 8 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Virology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Virology GA DG3DS UT WOS:000371950300008 PM 26808359 ER PT J AU Ender, MG Rohall, DE Matthews, MD AF Ender, Morten G. Rohall, David E. Matthews, Michael D. TI Cadet and Civilian Undergraduate Attitudes toward Transgender People: A Research Note SO ARMED FORCES & SOCIETY LA English DT Article DE transgender; military; undergraduates; attitudes; cadets; military academy ID MILITARY; GENDER; AFFILIATION AB We explore American military academy, Reserve Officers' Training Corps (ROTC) and civilian undergraduate attitudes toward transgender people in general, in the workplace, and in the military. Earlier this decade, the US military experienced both the repeals of the Don't Ask, Don't Tell policy and the exclusion of women from combat, yet transgender people are prohibited from serving openly in the military. This study explores tolerance toward perceived gender nonconformity by military affiliation, race/ethnicity, sex, religious affiliation, and political leaning. Most members of our sample, regardless of military affiliation, do not report that having a transgender person in the workplace would impact their job. At first glance, military academy and ROTC cadets are least tolerant of transgender people in the military and in society more generally. Further analyses shows that the impact of military affiliation is reduced substantially by controlling for background characteristics, especially political ideology and religious affiliation. C1 [Ender, Morten G.; Matthews, Michael D.] US Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA. [Rohall, David E.] Missouri State Univ, Dept Sociol & Anthropol, Springfield, MO USA. RP Ender, MG (reprint author), US Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA. EM morten.ender@usma.edu FU Palm Center; Faculty Development Research Grant through the United States Military Academy FX The authors disclosed the receipt of the following financial support for the research, authorship and/or publication of this article: Partial funding for this project was received from the Palm Center and a Faculty Development Research Grant through the United States Military Academy. NR 16 TC 0 Z9 0 U1 2 U2 6 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0095-327X EI 1556-0848 J9 ARMED FORCES SOC JI Armed Forces Soc. PD APR PY 2016 VL 42 IS 2 BP 427 EP 435 DI 10.1177/0095327X15575278 PG 9 WC Political Science; Sociology SC Government & Law; Sociology GA DF4GZ UT WOS:000371307300009 ER PT J AU Tweedell, AJ Ryan, ED Scharville, MJ Rosenberg, JG Sobolewski, EJ Kleinberg, CR AF Tweedell, Andrew J. Ryan, Eric D. Scharville, Michael J. Rosenberg, Joseph G. Sobolewski, Eric J. Kleinberg, Craig R. TI The influence of ultrasound measurement techniques on the age-related differences in Achilles tendon size SO EXPERIMENTAL GERONTOLOGY LA English DT Article DE Cross-sectional area; Thickness; Aging; Reliability ID CROSS-SECTIONAL AREA; TEST-RETEST RELIABILITY; IN-VIVO; PATELLAR TENDON; DOMINANCE; STRESS; ANKLE AB Achilles tendon (AT) properties change with age, however the extent to which aging influences the size of the AT may be influenced by the measurement technique. The purpose of this study was to 1) examine the age-related differences in AT size using measures of cross-sectional area (CSA) and thickness, and 2) to determine the test-retest reliability and minimum difference (MD) values of these measures. The size of the AT was examined in 19 young (19.79 +/- 2.3 years) and 18 older (69.4 +/- 3.1 years) healthy men on two separate occasions using an ultrasonography. The CSA and thickness of the AT were determined by separate transverse and longitudinal scans on the right leg at the same distance from the medial malleolus, respectively. Prior to and after accounting for body mass, AT CSA was larger (P <= 0.01) in the older men (64.49 +/- 13.87 mm(2)) when compared to the younger men (44.12 +/- 16.04 mm(2)), however there were no differences in AT thickness between age groups (P = 0.96). In addition, there was no systematic error (P > 0.05) between testing days, and the intraclass correlation coefficients, standard error of measurement (expressed as a % of the mean), and MD values for CSA and thickness ranged from 0.80-0.98, 5.46-8.68%, and 5.65-7.94 mm(2) and 0.51-0.86 mm, respectively between both groups. These findings suggest that the reliability of the CSA and thickness measurements were similar, however, CSA was a more sensitive measure to detect the age-related changes of AT size. (C) 2016 Elsevier Inc. All rights reserved. C1 [Tweedell, Andrew J.; Ryan, Eric D.; Kleinberg, Craig R.] Univ N Carolina, Dept Exercise & Sport Sci, Neuromuscular Res Lab, Chapel Hill, NC USA. [Tweedell, Andrew J.] Army Res Lab, Aberdeen, MD USA. [Ryan, Eric D.] Univ N Carolina, Allied Hlth Sci, Chapel Hill, NC USA. [Scharville, Michael J.] Quintiles Inc, Durham, NC USA. [Rosenberg, Joseph G.] Valencell Inc, Raleigh, NC USA. [Sobolewski, Eric J.] Texas Tech Univ, Dept Kinesiol & Sport Management, Human Performance Lab, Lubbock, TX 79409 USA. RP Ryan, ED (reprint author), Univ N Carolina, Dept Exercise & Sports Sci, 209 Fetzer Hall,CB 8700, Chapel Hill, NC 27599 USA.; Ryan, ED (reprint author), Univ N Carolina, Allied Hlth Sci, 209 Fetzer Hall,CB 8700, Chapel Hill, NC 27599 USA. EM edryan@email.unc.edu NR 16 TC 2 Z9 2 U1 0 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0531-5565 EI 1873-6815 J9 EXP GERONTOL JI Exp. Gerontol. PD APR PY 2016 VL 76 BP 68 EP 71 DI 10.1016/j.exger.2016.01.015 PG 4 WC Geriatrics & Gerontology SC Geriatrics & Gerontology GA DF4XQ UT WOS:000371355200009 PM 26827613 ER PT J AU Sviatenko, LK Gorb, L Shukla, MK Seiter, JM Leszczynska, D Leszczynski, J AF Sviatenko, Liudmyla K. Gorb, Leonid Shukla, Manoj K. Seiter, Jennifer M. Leszczynska, Danuta Leszczynski, Jerzy TI Adsorption of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20) on a soil organic matter. A DFT M05 computational study SO CHEMOSPHERE LA English DT Article DE Leonardite humic acid; Adsorption; AIM method; Redox potential; CL-20 ID ELECTRON-DENSITIES; ENVIRONMENTAL FATE; EXPLOSIVE CL-20; HYDROGEN-BONDS; MECHANISMS; REDUCTION; ACCURACY AB Adsorption of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20) by soil organic matter considering the Leonardite Humic Acid (LHA) model at the M05/tzvp level of Density Functional Theory. (DFT) applying cluster approximation has been investigated. Different orientations of CL-20 toward LHA surface were examined. It was found that deprotonation of LHA is required to obtain stable complexes with CL-20. Hydrogen bonds between CL-20 and deprotonated LHA were analyzed applying the atoms in molecules (AIM) theory. An attachment or removal of an electron with respect to the complex does not have significant effect on mutual orientation of the adsorbent in complexes. It was shown that adsorbed CL-20 does not undergo redox transformation and, therefore, adsorption on soil organic matter may be responsible for decrease of the degradation rate of CL-20 in soil. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Sviatenko, Liudmyla K.; Leszczynski, Jerzy] Jackson State Univ, Dept Chem & Biochem, Interdisciplinary Ctr Nanotox, 1325 JR Lynch St,POB 17910, Jackson, MS 39217 USA. [Sviatenko, Liudmyla K.] Oles Honchar Dnipropetrovsk Natl Univ, Dept Organ Chem, UA-49000 Dnepropetrovsk, Ukraine. [Gorb, Leonid] HX5 LLC, Vicksburg, MS 39180 USA. [Shukla, Manoj K.; Seiter, Jennifer M.] Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Leszczynska, Danuta] Jackson State Univ, Dept Civil & Environm Engn, Interdisciplinary Ctr Nanotox, Jackson, MS 39217 USA. RP Leszczynski, J (reprint author), Jackson State Univ, Dept Chem & Biochem, Interdisciplinary Ctr Nanotox, 1325 JR Lynch St,POB 17910, Jackson, MS 39217 USA. EM jerzy@icnanotox.org OI Shukla, Manoj /0000-0002-7560-1172 FU ERDC [W912HZ-13-P-0037]; National Science Foundation [OCI-1053575]; XSEDE award [DMR110088] FX We (DL and JL) thank ERDC for financial support (grant number is W912HZ-13-P-0037). The computation time was provided by the Extreme Science and Engineering Discovery Environment (XSEDE) by National Science Foundation Grant Number OCI-1053575 and XSEDE award allocation Number DMR110088 and by the Mississippi Center for Supercomputer Research. NR 32 TC 1 Z9 1 U1 6 U2 23 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 EI 1879-1298 J9 CHEMOSPHERE JI Chemosphere PD APR PY 2016 VL 148 BP 294 EP 299 DI 10.1016/j.chemosphere.2016.01.011 PG 6 WC Environmental Sciences SC Environmental Sciences & Ecology GA DF1KX UT WOS:000371099700036 PM 26814703 ER PT J AU Golius, A Gorb, L Scott, AM Hill, FC Shukla, M Goins, AB Johnson, DR Leszczynski, J AF Golius, Anastasiia Gorb, Leonid Scott, Andrea Michalkova Hill, Frances C. Shukla, Manoj Goins, A. Benjamin Johnson, David R. Leszczynski, Jerzy TI Experimental and computational study of membrane affinity for selected energetic compounds SO CHEMOSPHERE LA English DT Article DE Partition coefficient; Artificial bilayer lipid membranes; Energetic compounds; Theoretical study ID MOLECULAR-DYNAMICS SIMULATIONS; WATER PARTITION-COEFFICIENTS; LIPID-BILAYERS; POLYCHLORINATED-BIPHENYLS; ORGANIC-CHEMICALS; PREDICTION; BASES; ACIDS; ACCUMULATE; SURFACE AB The affinity of various energetic compounds for a biological membrane was investigated using experimental and computational techniques. We measured octanol-water (log(K-ow)) and liposome-water (log(K-lipw)) partition coefficients for the following chemicals: trinitrotoluene (TNT), 2,4-dinitrotoluene (2,4-DNT), 2,6-dinitrotoluene (2,6-DNT), 2,4-dinitroanisole (DNAN), 2methoxy-5-nitrophenol (2M5NP), 2,4,6-trinitrobenzene (TNB), and 2,4-dinitrophenol (2,4-DNP). In order to determine log(Klipw) experimentally, we used artificial solid supported lipid liposomes produced under trade mark TRANSIL. Log(K-ow) value were predicted with several program packages including the COSMOthermX software. Log(K-lipw) were estimated with COSMOmic as implemented in the COSMOthermX program package. In order to verify accuracy of our experimentally obtained results, we performed basic statistical analysis of data taken from the literature. We concluded that compounds considered in this study possess a moderate ability to penetrate into membranes. Comparison of both coefficients has shown that in general, the log(K-ow) values are slightly smaller than log(K-lipw). (C) 2016 Elsevier Ltd. All rights reserved. C1 [Golius, Anastasiia; Leszczynski, Jerzy] Jackson State Univ, Dept Chem & Biochem, Jackson, MS 39217 USA. [Gorb, Leonid] HX5 LLC, Vicksburg, MS USA. [Scott, Andrea Michalkova; Hill, Frances C.; Shukla, Manoj] US Army Engineer Res & Dev Ctr, Vicksburg, MS USA. [Goins, A. Benjamin] iMedDo Inc, POB 137103, Ft Worth, TX 76136 USA. [Johnson, David R.] Conostoga Rovers & Associates, Dallas, TX USA. RP Leszczynski, J (reprint author), Jackson State Univ, Dept Chem & Biochem, Interdisciplinary Ctr Nanotox, 1400 JR Lynch St,POB 17910, Jackson, MS 39217 USA. EM jerzy@icnanotox.org FU NSF CREST Interdisciplinary Nanotoxicity Center NSF-CREST - Grant [HRD-0833178]; Extreme Science and Engineering Discovery Environment (XSEDE) by National Science Foundation [OCI-1053575]; XSEDE award [DMR110088]; Environmental Quality Technology Program of the United States Army Corps of Engineers by the U.S. Army ERDC FX The authors thank the support of the NSF CREST Interdisciplinary Nanotoxicity Center NSF-CREST - Grant # HRD-0833178; This research was supported in part by the Extreme Science and Engineering Discovery Environment (XSEDE) by National Science Foundation grant number OCI-1053575 and XSEDE award allocation number DMR110088. The authors are grateful to the Mississippi Center for Supercomputing Research (MCSR) for providing state-of-the-art high performance computing facilities and excellent services for supporting this research.; The use of trade, product, or firm names in this report is for descriptive purposes only and does not imply endorsement by the U.S. Government. Results in this study were funded and obtained from research conducted under the Environmental Quality Technology Program of the United States Army Corps of Engineers by the U.S. Army ERDC. Permission was granted by the Chief of Engineers to publish this information. The findings of this report are not to be construed as an official Department of the Army position unless so designated by other authorized documents. NR 51 TC 0 Z9 0 U1 2 U2 15 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 EI 1879-1298 J9 CHEMOSPHERE JI Chemosphere PD APR PY 2016 VL 148 BP 322 EP 327 DI 10.1016/j.chemosphere.2016.01.010 PG 6 WC Environmental Sciences SC Environmental Sciences & Ecology GA DF1KX UT WOS:000371099700040 PM 26820779 ER PT J AU Walker, RW Ashton, NK Brown, RS Liss, SA Colotelo, AH Beirao, BV Townsend, RL Deng, ZD Eppard, MB AF Walker, Ricardo W. Ashton, Neil K. Brown, Richard S. Liss, Stephanie A. Colotelo, Alison H. Beirao, Bernardo V. Townsend, Richard L. Deng, Z. Daniel Eppard, M. Brad TI Effects of a novel acoustic transmitter on swimming performance and predator avoidance of juvenile Chinook Salmon: Determination of a size threshold SO FISHERIES RESEARCH LA English DT Article DE Behavior; Dam passage; Juvenile Salmon Acoustic Telemetry System; Migration; Telemetry ID EXTERNALLY ATTACHED TRANSMITTERS; RADIO TRANSMITTERS; MAXIMUM TAG; COHO SALMON; GROWTH; IMPLANTATION; SURVIVAL; TROUT; PHYSIOLOGY; RETENTION AB The miniaturization of acoustic transmitters enables researchers to tag smaller fish for telemetry studies, thus representing a greater proportion of the population of interest. Fish having a smaller transmitter burden (e.g., the weight of the transmitter relative to the weight of the fish) may also have fewer potential adverse transmitter effects. The development of an injectable acoustic transmitter has led to research that determined the least invasive and quickest method of implantation. Following that research, the objectives of this study were to determine the effects of transmitter implantation on swimming performance and predator avoidance, and to find a minimum size threshold of fish that can be tagged without adversely affecting those responses. To assess critical swimming speed (U-crit; an index of prolonged swimming performance) and predator avoidance for juvenile Chinook Salmon (Oncorhynchus tshawytscha), fish were split into three treatments: (1) implantation with a dummy injectable acoustic transmitter (IAT treatment), (2) implantation with a dummy injectable acoustic transmitter and passive integrated transponder tag (IAT + PIT treatment), and (3) an untagged control. IAT treatment fish had lower U-crit values than untagged controls among individuals below 79 mm fork length (transmitter burden 3.4-4.0%). U-crit values for the IAT + PIT treatment were not significantly different from untagged controls and no size threshold was found. There was no significant difference in predator avoidance between fish implanted with the IAT or IAT + PIT compared to untagged controls. These guidelines could provide researchers and managers with a powerful tool to examine behavior and survival of small salmonids. (C) 2016 Elsevier B.V. All rights reserved. C1 [Walker, Ricardo W.; Ashton, Neil K.; Brown, Richard S.; Liss, Stephanie A.; Colotelo, Alison H.] Pacific NW Natl Lab, Ecol Grp, Richland, WA 99352 USA. [Beirao, Bernardo V.] Univ Fed Sao Joao del Rei, Ouro Branco, MG, Brazil. [Townsend, Richard L.] Univ Washington, Sch Aquat & Fishery Sci, Columbia Basin Res, Seattle, WA 98101 USA. [Deng, Z. Daniel] Pacific NW Natl Lab, Hydrol Grp, Richland, WA 99352 USA. [Eppard, M. Brad] US Army Corps Engineers, Portland, OR 97208 USA. RP Liss, SA (reprint author), Pacific NW Natl Lab, Ecol Grp, Richland, WA 99352 USA. EM stephanie.liss@pnnl.gov RI Deng, Daniel/A-9536-2011 OI Deng, Daniel/0000-0002-8300-8766 FU Army Corps of Engineers, Portland District FX We would like to the thank the Army Corps of Engineers, Portland District, for providing the funding for this research. We would also like to thank the Washington Department of Fish and Wildlife Leavenworth and Priest Rapids Hatcheries for providing the salmon used in this study. We also thank John Skalski from the University of Washington for statistical advice and Thomas Hancock from Portland State University for providing assistance with the swimming chambers. We appreciate the assistance from the following PNNL staff Zach Booth, Nikki Fuller, David Geist, Jill Janak, Brian Jeide, Bryan Jones, Ki Won Jung, Tim Linley, Jun Lu, Jayson Martinez, Brett Pflugrath, Jason Reynolds, and John Stephenson. NR 30 TC 4 Z9 4 U1 4 U2 24 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-7836 EI 1872-6763 J9 FISH RES JI Fish Res. PD APR PY 2016 VL 176 BP 48 EP 54 DI 10.1016/j.fishres.2015.12.007 PG 7 WC Fisheries SC Fisheries GA DE0HZ UT WOS:000370307000006 ER PT J AU Bernstock, JD Budinich, CS Cohen, LG Awosika, OO AF Bernstock, Joshua D. Budinich, Craig S. Cohen, Leonardo G. Awosika, Oluwole O. TI Recrudescence of Focal stroke symptoms during pain Management with Hydromorphone SO FRONTIERS IN NEUROLOGY LA English DT Article DE stroke; pain management; opioids; plasticity; recrudescence of symptoms ID NEUROLOGICAL DEFICITS; MIDAZOLAM CHALLENGE; OPIOID RECEPTORS; NALOXONE; RECOVERY; REVERSAL; MEMORY AB Patients who have recovered from a prior stroke may experience a reemergence of their original stroke syndrome secondary to metabolic derangements, sedation, infection, and/or fatigue. Critically, the molecular/cellular mechanisms mediating symptom recurrence after exposure to analgesic agents remain unknown. Accordingly, herein, we report a unique case of a patient with hydromorphone-induced recrudescence 30 years after her initial stroke event(s) and in so doing propose a putative mechanism related to post-infarction functional neuroplasticity. C1 [Bernstock, Joshua D.] NINDS, Stroke Sect, NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA. [Budinich, Craig S.] Dwight D Eisenhower Army Med Ctr, Dept Anesthesiol, Ft Gordon, GA USA. [Cohen, Leonardo G.; Awosika, Oluwole O.] NINDS, Human Cort Physiol & Stroke Neurorehabil Sect, NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA. RP Awosika, OO (reprint author), NINDS, Human Cort Physiol & Stroke Neurorehabil Sect, NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA. EM awosikaoo@ninds.nih.gov FU Intramural Research Program of the National Institute of Neurological Disorders and Stroke, National Institutes of Health (NINDS/NIH) FX The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: this work was supported by the Intramural Research Program of the National Institute of Neurological Disorders and Stroke, National Institutes of Health (NINDS/NIH). NR 18 TC 0 Z9 0 U1 1 U2 2 PU FRONTIERS MEDIA SA PI LAUSANNE PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLAND SN 1664-2295 J9 FRONT NEUROL JI Front. Neurol. PD MAR 31 PY 2016 VL 7 AR 50 DI 10.3389/fneur.2016.00050 PG 3 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA DI0IH UT WOS:000373178400001 PM 27064505 ER PT J AU Stefan, CP Chase, K Coyne, S Kulesh, DA Minogue, TD Koehler, JW AF Stefan, Christopher P. Chase, Kitty Coyne, Susan Kulesh, David A. Minogue, Timothy D. Koehler, Jeffrey W. TI Development of real-time reverse transcriptase qPCR assays for the detection of Punta Toro virus and Pichinde virus SO VIROLOGY JOURNAL LA English DT Article DE Real-time RT-qPCR; Pichinde virus; Punta Toro virus; Bunyaviruses; Arenaviruses ID RIFT-VALLEY FEVER; SAUDI-ARABIA; LASSA FEVER; GUINEA-PIGS; INFECTION; HAMSTERS; DISEASE; PHLEBOVIRUS; RIBAVIRIN; MODEL AB Background: Research with high biocontainment pathogens such as Rift Valley fever virus (RVFV) and Lassa virus (LASV) is expensive, potentially hazardous, and limited to select institutions. Surrogate pathogens such as Punta Toro virus (PTV) for RVFV infection and Pichinde virus (PICV) for LASV infection allow research to be performed under more permissive BSL-2 conditions. Although used as infection models, PTV and PICV have no standard real-time RT-qPCR assays to detect and quantify pathogenesis. PTV is also a human pathogen, making a standardized detection assay essential for biosurveillance. Here, we developed and characterized two real-time RT-qPCR assays for PICV and PTV by optimizing assay conditions and measuring the limit of detection (LOD) and performance in multiple clinical matrices. Methods: Total nucleic acid from virus-infected Vero E6 cells was used to optimize TaqMan-minor groove binder (MGB) real-time RT-qPCR assays. A 10-fold dilution series of nucleic acid was used to perform analytical experiments with 60 replicates used to confirm assay LODs. Serum and whole blood spiked with 10-fold dilutions of PTV and PICV virus were assessed as matrices in a mock clinical context. The Cq, or cycle at which the fluoresce of each sample first crosses a threshold line, was determined using the second derivative method using Roche LightCycler 480 software version 1.5.1. Digital droplet PCR (ddPCR) was utilized to quantitatively determine RNA target counts/mu l for PTV and PICV. Results: Optimized PTV and PICV assays had LODs of 1000 PFU/ml and 100 PFU/ml, respectively, and this LOD was confirmed in 60/60 (PTV) and 58/60 (PICV) positive replicates. Preliminary mock clinical LODs remained consistent in serum and whole blood for PTV and PICV at 1000 PFU/ml and 100 PFU/ml. An exclusivity panel showed no cross reaction with near neighbors. Conclusions: PTV and PICV Taq-man MGB based real-time RT-qPCR assays developed here showed relevant sensitivity and reproducibility in samples extracted from a variety of clinical matrices. These assays will be useful as a standard by researchers for future experiments utilizing PTV and PICV as infection models, offering the ability to track infection and viral replication kinetics during research studies. C1 [Stefan, Christopher P.; Chase, Kitty; Coyne, Susan; Kulesh, David A.; Minogue, Timothy D.; Koehler, Jeffrey W.] US Army, Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. RP Koehler, JW (reprint author), US Army, Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. EM jeff.w.koehler.ctr@mail.mil OI Koehler, Jeffrey/0000-0003-3225-6599 FU Defense Threat Reduction Agency (DTRA) [11467651] FX This work was supported by the Defense Threat Reduction Agency (DTRA) 11467651. The opinions, interpretations, conclusions, and recommendations contained herein are those of the authors and are not necessarily endorsed by the U.S. Army. The authors would also like to thank Cindy Rossi and the UCC for supplying some of the viruses used in the studies NR 29 TC 2 Z9 2 U1 1 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1743-422X J9 VIROL J JI Virol. J. PD MAR 31 PY 2016 VL 13 AR 54 DI 10.1186/s12985-016-0509-3 PG 6 WC Virology SC Virology GA DI1OK UT WOS:000373265200001 PM 27029488 ER PT J AU Subramanian, V Semenzin, E Hristozov, D Zabeo, A Malsch, I McAlea, E Murphy, F Mullins, M van Harmelen, T Ligthart, T Linkov, I Marcomini, A AF Subramanian, Vrishali Semenzin, Elena Hristozov, Danail Zabeo, Alex Malsch, Ineke McAlea, Eamonn Murphy, Finbarr Mullins, Martin van Harmelen, Toon Ligthart, Tom Linkov, Igor Marcomini, Antonio TI Sustainable nanotechnology decision support system: bridging risk management, sustainable innovation and risk governance SO JOURNAL OF NANOPARTICLE RESEARCH LA English DT Article DE Decision support system; Sustainable nanotechnology; Risk governance; Risk management; Engineered nanomaterials ID LIFE-CYCLE ASSESSMENT; ENGINEERED NANOMATERIALS AB The significant uncertainties associated with the (eco)toxicological risks of engineered nanomaterials pose challenges to the development of nanoenabled products toward greatest possible societal benefit. This paper argues for the use of risk governance approaches to manage nanotechnology risks and sustainability, and considers the links between these concepts. Further, seven risk assessment and management criteria relevant to risk governance are defined: (a) life cycle thinking, (b) triple bottom line, (c) inclusion of stakeholders, (d) risk management, (e) benefitrisk assessment, (f) consideration of uncertainty, and (g) adaptive response. These criteria are used to compare five well-developed nanotechnology frameworks: International Risk Governance Council framework, Comprehensive Environmental Assessment, Streaming Life Cycle Risk Assessment, Certifiable Nanospecific Risk Management and Monitoring System and LICARA NanoSCAN. A Sustainable Nanotechnology Decision Support System (SUNDS) is proposed to better address current nanotechnology risk assessment and management needs, and makes. Stakeholder needs were solicited for further SUNDS enhancement through a stakeholder workshop that included representatives from regulatory, industry and insurance sectors. Workshop participants expressed the need for the wider adoption of sustainability assessment methods and tools for designing greener nanomaterials. C1 [Subramanian, Vrishali; Semenzin, Elena; Hristozov, Danail; Zabeo, Alex; Linkov, Igor; Marcomini, Antonio] Univ Ca Foscari Venice, Dept Environm Sci Informat & Stat, Venice, Italy. [Malsch, Ineke] Malsch TechnoValuat, Utrecht, Netherlands. [McAlea, Eamonn; Murphy, Finbarr; Mullins, Martin] Univ Limerick, Kemmy Business Sch, Limerick, Ireland. [van Harmelen, Toon; Ligthart, Tom] TNO, Utrecht, Netherlands. [Linkov, Igor] US Army Engineer Res & Dev Ctr, Concord, MA USA. RP Marcomini, A (reprint author), Univ Ca Foscari Venice, Dept Environm Sci Informat & Stat, Venice, Italy. EM vrishali.subramanian@unive.it; marcom@unive.it RI Murphy, Finbarr/B-5254-2015; Zabeo, Alex/D-6715-2014; OI Murphy, Finbarr/0000-0002-7463-7923; Zabeo, Alex/0000-0001-7162-5364; Hristozov, Danail/0000-0002-2386-7366 FU European Union Seventh Framework Programme under ECGA [604305] FX This study was funded in part by the European Union Seventh Framework Programme [FP7/2007-2013] under ECGA No. 604305 "SUN''. This publication reflects the views only of the authors, and the European Commission and other sponsors cannot be held responsible for any use, which may be made of the information contained therein. NR 63 TC 3 Z9 3 U1 11 U2 23 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1388-0764 EI 1572-896X J9 J NANOPART RES JI J. Nanopart. Res. PD MAR 30 PY 2016 VL 18 IS 4 AR UNSP 89 DI 10.1007/s11051-016-3375-4 PG 13 WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA DI2ZK UT WOS:000373367700001 ER PT J AU Timmermans, A Melendrez, MC Se, Y Chuang, I Samon, N Uthaimongkol, N Klungthong, C Manasatienkij, W Thaisomboonsuk, B Tyner, SD Rith, S Horm, VS Jarman, RG Bethell, D Chanarat, N Pavlin, J Wongstitwilairoong, T Saingam, P El, BS Fukuda, MM Touch, S Sovann, L Fernandez, S Buchy, P Chanthap, L Saunders, D AF Timmermans, Ans Melendrez, Melanie C. Se, Youry Chuang, Ilin Samon, Nou Uthaimongkol, Nichapat Klungthong, Chonticha Manasatienkij, Wudtichai Thaisomboonsuk, Butsaya Tyner, Stuart D. Rith, Sareth Horm, Viseth Srey Jarman, Richard G. Bethell, Delia Chanarat, Nitima Pavlin, Julie Wongstitwilairoong, Tippa Saingam, Piyaporn El, But Sam Fukuda, Mark M. Touch, Sok Sovann, Ly Fernandez, Stefan Buchy, Philippe Chanthap, Lon Saunders, David TI Human Sentinel Surveillance of Influenza and Other Respiratory Viral Pathogens in Border Areas of Western Cambodia SO PLOS ONE LA English DT Article ID MOUTH-DISEASE OUTBREAK; A VIRUS; PHYLOGENETIC ANALYSIS; ANTIGENIC VARIATION; CLINICAL SPECIMENS; SEQUENCE ALIGNMENT; EVOLUTION; CHILDREN; HEMAGGLUTININ; DATAMONKEY AB Little is known about circulation of influenza and other respiratory viruses in remote populations along the Thai-Cambodia border in western Cambodia. We screened 586 outpatients (median age 5, range 1-77) presenting with influenza-like-illness (ILI) at 4 sentinel sites in western Cambodia between May 2010 and December 2012. Real-time reverse transcriptase (rRT) PCR for influenza was performed on combined nasal and throat specimens followed by viral culture, antigenic analysis, antiviral susceptibility testing and full genome sequencing for phylogenetic analysis. ILI-specimens negative for influenza were cultured, followed by rRT-PCR for enterovirus and rhinovirus (EV/RV) and EV71. Influenza was found in 168 cases (29%) and occurred almost exclusively in the rainy season from June to November. Isolated influenza strains had close antigenic and phylogenetic relationships, matching vaccine and circulating strains found elsewhere in Cambodia. Influenza vaccination coverage was low (<20%). Western Cambodian H1N1(2009) isolate genomes were more closely related to 10 earlier Cambodia isolates (94.4% genome conservation) than to 13 Thai isolates (75.9% genome conservation), despite sharing the majority of the amino acid changes with the Thai references. Most genes showed signatures of purifying selection. Viral culture detected only adenovirus (5.7%) and parainfluenza virus (3.8%), while non-polio enteroviruses (10.3%) were detected among 164 culture-negative samples including coxsackievirus A4, A6, A8, A9, A12, B3, B4 and echovirus E6 and E9 using nested RT-PCR methods. A single specimen of EV71 was found. Despite proximity to Thailand, influenza epidemiology of these western Cambodian isolates followed patterns observed elsewhere in Cambodia, continuing to support current vaccine and treatment recommendations from the Cambodian National Influenza Center. Amino acid mutations at non-epitope sites, particularly hemagglutinin genes, require further investigation in light of an increasingly important role of permissive mutations in influenza virus evolution. Further research about the burden of adenovirus and non-polio enteroviruses as etiologic agents in acute respiratory infections in Cambodia is also needed. C1 [Timmermans, Ans; Chuang, Ilin; Tyner, Stuart D.; Bethell, Delia; Fukuda, Mark M.; Fernandez, Stefan; Saunders, David] US Armed Forces Res Inst Med Sci, Dept Immunol, Bangkok, Thailand. [Melendrez, Melanie C.; Jarman, Richard G.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD USA. [Se, Youry; Samon, Nou; El, But Sam] Armed Forces Res Inst Med Sci, Dept Immunol, Battambang, Cambodia. [Uthaimongkol, Nichapat; Klungthong, Chonticha; Manasatienkij, Wudtichai; Thaisomboonsuk, Butsaya; Chanarat, Nitima; Wongstitwilairoong, Tippa; Saingam, Piyaporn] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Rith, Sareth; Horm, Viseth Srey; Buchy, Philippe] Inst Pasteur Cambodge, Dept Virol, Phnom Penh, Cambodia. [Pavlin, Julie] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD USA. [Touch, Sok; Sovann, Ly] Minist Hlth, Dept Communicable Dis Control, Phnom Penh, Cambodia. [Chanthap, Lon] Armed Forces Res Inst Med Sci, Dept Immunol, Phnom Penh, Cambodia. [Timmermans, Ans] Maastricht Univ, Fac Hlth Med & Life Sci, NL-6200 MD Maastricht, Netherlands. [Tyner, Stuart D.] US Army Inst Surg Res, Houston, TX USA. [Pavlin, Julie] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Henry M Jackson Fdn Adv Mil Med Inc, Bethesda, MD USA. [Buchy, Philippe] GSK Vaccines, R&D, Singapore, Singapore. RP Melendrez, MC (reprint author), Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD USA. EM mmelendrez@gmail.com OI Melendrez, Melanie/0000-0002-4811-4467 FU Armed Forces Health Surveillance Center's Global Emerging Infections and Response System FX Funding was provided by The Armed Forces Health Surveillance Center's Global Emerging Infections and Response System. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 53 TC 0 Z9 0 U1 0 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAR 30 PY 2016 VL 11 IS 3 AR e0152529 DI 10.1371/journal.pone.0152529 PG 23 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DH9LB UT WOS:000373116500051 PM 27028323 ER PT J AU Mendoza, PA Clark, MP Mizukami, N Gutmann, ED Arnold, JR Brekke, LD Rajagopalan, B AF Mendoza, Pablo A. Clark, Martyn P. Mizukami, Naoki Gutmann, Ethan D. Arnold, Jeffrey R. Brekke, Levi D. Rajagopalan, Balaji TI How do hydrologic modeling decisions affect the portrayal of climate change impacts? SO HYDROLOGICAL PROCESSES LA English DT Article DE climate change; hydrologic modelling; subjectivity; uncertainty ID WESTERN UNITED-STATES; COLORADO RIVER-BASIN; METEOROLOGICAL FORCING DATA; ASSIMILATION SYSTEM NLDAS; NORTH-AMERICAN CLIMATE; RAINFALL-RUNOFF MODELS; SELF-ORGANIZING MAPS; CATCHMENT CLASSIFICATION; ASSESSING UNCERTAINTIES; WINTER PRECIPITATION AB End users face a range of subjective decisions when evaluating climate change impacts on hydrology, but the importance of these decisions is rarely assessed. In this paper, we evaluate the implications of hydrologic modelling choices on projected changes in the annual water balance, monthly simulated processes, and signature measures (i.e. metrics that quantify characteristics of the hydrologic catchment response) under a future climate scenario. To this end, we compare hydrologic changes computed with four different model structures - whose parameters have been obtained using a common calibration strategy - with hydrologic changes computed with a single model structure and parameter sets from multiple options for different calibration decisions (objective function, local optima, and calibration forcing dataset). Results show that both model structure selection and the parameter estimation strategy affect the direction and magnitude of projected changes in the annual water balance, and that the relative effects of these decisions are basin dependent. The analysis of monthly changes illustrates that parameter estimation strategies can provide similar or larger uncertainties in simulations of some hydrologic processes when compared with uncertainties coming from model choice. We found that the relative effects of modelling decisions on projected changes in catchment behaviour depend on the signature measure analysed. Furthermore, parameter sets with similar performance, but located in different regions of the parameter space, provide very different projections for future catchment behaviour. More generally, the results obtained in this study prompt the need to incorporate parametric uncertainty in multi-model frameworks to avoid an over-confident portrayal of climate change impacts. Copyright (c) 2015 John Wiley & Sons, Ltd. C1 [Mendoza, Pablo A.; Rajagopalan, Balaji] Univ Colorado, Dept Civil Environm & Architectural Engn, Boulder, CO 80309 USA. [Mendoza, Pablo A.; Rajagopalan, Balaji] Univ Colorado, Cooperat Inst Res Environm Sci, Boulder, CO 80309 USA. [Mendoza, Pablo A.; Clark, Martyn P.; Mizukami, Naoki; Gutmann, Ethan D.] Natl Ctr Atmospher Res, Hydrometeorol Applicat Program, POB 3000, Boulder, CO 80307 USA. [Arnold, Jeffrey R.] US Army, Corps Engn, Climate Preparedness & Resilience Programs, Seattle, WA USA. [Brekke, Levi D.] Bur Reclamat, Denver, CO USA. RP Mendoza, PA (reprint author), Natl Ctr Atmospher Res, Res Applicat Lab, POB 3000, Boulder, CO 80307 USA. EM pmendoza@ucar.edu RI Gutmann, Ethan/I-5728-2012 OI Gutmann, Ethan/0000-0003-4077-3430 FU U.S. Army Corps of Engineers; Bureau of Reclamation; Cooperative Institute for Research and Environmental Sciences (CIRES); National Science Foundation FX We thank Oldrich Rakovec and Mary Hill for their feedback in the implementation of DELSA, and Kyoko Ikeda for her help with WRF datasets. We are also grateful to Marketa Elsner, Andy Newman, Michael Barlage, Roland Viger, Adam Carheden, and Tor Mohling for their feedback and assistance for setting up the models. This work was supported through a contract with the U.S. Army Corps of Engineers, through a cooperative agreement with the Bureau of Reclamation, and through a graduate fellowship from the Cooperative Institute for Research and Environmental Sciences (CIRES). The National Center for Atmospheric Research is sponsored by the National Science Foundation. Finally, we thank two anonymous reviewers for their highly constructive comments, which contributed considerably to improve this manuscript. NR 137 TC 3 Z9 3 U1 7 U2 20 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0885-6087 EI 1099-1085 J9 HYDROL PROCESS JI Hydrol. Process. PD MAR 30 PY 2016 VL 30 IS 7 BP 1071 EP 1095 DI 10.1002/hyp.10684 PG 25 WC Water Resources SC Water Resources GA DH8CR UT WOS:000373021600005 ER PT J AU Varady, MJ Pearl, TP Stevenson, SM Mantooth, BA AF Varady, Mark J. Pearl, Thomas P. Stevenson, Shawn M. Mantooth, Brent A. TI Decontamination of VX from Silicone: Characterization of Multicomponent Diffusion Effects SO INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH LA English DT Article ID CHEMICAL WARFARE AGENTS; MODELING SORPTION; MASS-TRANSFER; DEGRADATION; MIXTURES; SYSTEMS; PERVAPORATION; COEFFICIENTS; FORMULATION; SEPARATION AB A continuum model of the transport and reaction processes occurring during decontamination of the chemical warfare agent (CWA) [2-(diisopropylamino)ethyl]-O-ethyl methylphosphonothioate (VX) absorbed in a-silicone elastomer using solutions of sodium hydroxide in water, methanol, and mixtures thereof is presented. This model is based on the Maxwell-Stefan formulation of multicomponent diffusion along with the Flory-Huggins model of thermodynamic equilibrium in the polymer. It was found that, as methanol from the decontaminant absorbs into the silicone, the diffusivity of VX increases, accelerating its flux from the polymer phase to the decontaminant liquid phase. This composition dependence of the diffusivity was accurately described by the Vignes equation. Although the decontamination kinetics were slower for the methanol-based decontaminant in a well-stirred liquid-phase reactor, the overall performance was superior compared to the aqueous-based decontaminant due to the enhanced extraction rate from the polymer. These findings highlight the need to consider extraction dynamics on equal footing with reaction kinetics when formulating decontaminants intended for use on absorbing polymer materials. C1 [Varady, Mark J.; Pearl, Thomas P.] OptiMetrics Inc, DCS Co, 100 Walter Ward Blvd,Suite 100, Abingdon, MD 21009 USA. [Stevenson, Shawn M.; Mantooth, Brent A.] US Army, Edgewood Chem Biol Ctr, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. RP Mantooth, BA (reprint author), US Army, Edgewood Chem Biol Ctr, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM brent.a.mantooth.civ@mail.mil FU Defense Threat Reduction Agency (DTRA) [CB3062] FX The authors thank Jerry Glasow, Eric Lowenstein, and Michael Roberts at the Defense Threat Reduction Agency (DTRA) for funding this work under program CB3062. The authors thank Janlyn Eikenberg, Janet Fouse, Stefanie Smallwood, Nicholas Sapienza, and Amanda Schenning for their support in performing the experiments and Michael Chesebrough for performing the chromatography analysis. The contributions from M.J.V. and T.P.P. were performed under contract at the Edgewood Chemical Biological Center. NR 44 TC 1 Z9 1 U1 6 U2 17 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0888-5885 J9 IND ENG CHEM RES JI Ind. Eng. Chem. Res. PD MAR 23 PY 2016 VL 55 IS 11 BP 3139 EP 3149 DI 10.1021/acs.iecr.5b04826 PG 11 WC Engineering, Chemical SC Engineering GA DH5TK UT WOS:000372854600023 ER PT J AU Farmer, A Wang, X Ganesan, A Deiss, RG Agan, BK O'Bryan, TA Akers, K Okulicz, JF AF Farmer, Aaron Wang, Xun Ganesan, Anuradha Deiss, Robert G. Agan, Brian K. O'Bryan, Thomas A. Akers, Kevin Okulicz, Jason F. TI Factors associated with HIV viral load "blips" and the relationship between self-reported adherence and efavirenz blood levels on blip occurrence: a case-control study SO AIDS RESEARCH AND THERAPY LA English DT Article DE Self-reported adherence; Human immunodeficiency virus; Blips ID ACTIVE ANTIRETROVIRAL THERAPY; SINGLE-TABLET REGIMEN; TRANSIENT VIREMIA; INFECTED PATIENTS; CLINICAL-SIGNIFICANCE; INTERMITTENT VIREMIA; DRUG-RESISTANCE; NATURAL-HISTORY; HAART; SUPPRESSION AB Background: The uncertain etiology of HIV viral load (VL) blips may lead to increased use of clinical resources. We evaluated the association of self-reported adherence (SRA) and antiretroviral (ART) drug levels on blip occurrence in US Military HIV Natural History Study (NHS) participants who initiated the single-tablet regimen efavirenz/emtricitabine/tenofovir disoproxil fumarate (EFV/FTC/TDF). Methods: ART-naive NHS participants started on EFV/FTC/TDF between 2006 and 2013 who achieved VL suppression (<50 copies/mL) within 12 months and had available SRA and stored plasma samples were included. Participants with viral blips were compared with those who maintained VL suppression without blips. Untimed EFV plasma levels were evaluated on consecutive blip and non-blip dates by high performance liquid chromatography, with a level >= 1 mcg/mL considered therapeutic. SRA was categorized as >= 85 or <85 %. Descriptive statistics were performed for baseline characteristics and univariate and multivariate Cox proportional hazard models were used to assess the relationship between covariates and blip occurrence. Results: A total of 772 individuals met inclusion criteria, including 99 (13 %) blip and 673 (87 %) control participants. African-American was the predominant ethnicity and the mean age was 29 years for both groups. SRA >= 85 % was associated with therapeutic EFV levels at both blip and non-blip time points (P = 0.0026); however no association was observed between blips and SRA or EFV levels among cases. On univariate analysis of cases versus controls, blips were associated with higher mean pre-treatment VL (HR 1.45, 95 % CI 1.11-1.89) and pre-treatment CD4 count <350 cells/mu L (68.1 vs 49.7 %). Multivariate analysis also showed that blips were associated with a higher mean VL (HR 1.42, 95 % CI 1.08-1.88; P = 0.0123) and lower CD4 count at ART initiation, with CD4 >= 500 cells/mu L having a protective effect (HR 0.45, 95 % CI 0.22-0.95; P = 0.0365). No association was observed for demographic characteristics or SRA. Conclusion: Blips are commonly encountered in the clinical management of HIV-infected patients. Although blip occurrence was not associated with SRA or EFV blood levels in our study, blips were associated with HIV-related factors of pre-ART high VL and low CD4 count. Additional studies are needed to determine the etiology of blips in HIV-infected patients. C1 [Farmer, Aaron; O'Bryan, Thomas A.; Akers, Kevin; Okulicz, Jason F.] San Antonio Mil Med Ctr, Infect Dis Serv, 3551 Roger Brooke Dr, Ft Sam Houston, TX USA. [Wang, Xun; Ganesan, Anuradha; Deiss, Robert G.; Agan, Brian K.; O'Bryan, Thomas A.; Okulicz, Jason F.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biostat, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Ganesan, Anuradha] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA. [Deiss, Robert G.] Naval Med Ctr San Diego, Div Infect Dis, San Diego, CA USA. [Akers, Kevin] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Wang, Xun; Ganesan, Anuradha; Deiss, Robert G.; Agan, Brian K.; O'Bryan, Thomas A.] Henry M Jackson Fdn Adv Mil Med Inc, Bethesda, MD USA. RP Okulicz, JF (reprint author), San Antonio Mil Med Ctr, Infect Dis Serv, 3551 Roger Brooke Dr, Ft Sam Houston, TX USA.; Okulicz, JF (reprint author), Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biostat, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. EM Jason.f.okulicz.mil@mail.mil OI Agan, Brian/0000-0002-5114-1669 FU Infectious Disease Clinical Research Program (IDCRP), a Department of Defense (DoD) program through the Uniformed Services University of the Health Sciences [IDCRP-000-03]; National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH) [Y1-AI-5072] FX The content of this publication is the sole responsibility of the authors and does not necessarily reflect the views or policies of the NIH or the Department of Health and Human Services, the DoD or the Departments of the Army, Navy or Air Force. Mention of trade names, commercial products, or organizations does not imply endorsement by the US Government. Support for this work (IDCRP-000-03) was provided by the Infectious Disease Clinical Research Program (IDCRP), a Department of Defense (DoD) program executed through the Uniformed Services University of the Health Sciences. This project has been funded in whole, or in part, with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), under Inter-Agency Agreement Y1-AI-5072. NR 35 TC 1 Z9 1 U1 2 U2 3 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-6405 J9 AIDS RES THER JI Aids Res. Ther. PD MAR 22 PY 2016 VL 13 AR 16 DI 10.1186/s12981-016-0100-4 PG 8 WC Infectious Diseases SC Infectious Diseases GA DH2CF UT WOS:000372591100001 PM 27905999 ER PT J AU Hammamieh, R Muhie, S Borschel, R Gautam, A Miller, SA Chakraborty, N Jett, M AF Hammamieh, Rasha Muhie, Seid Borschel, Richard Gautam, Aarti Miller, Stacy-Ann Chakraborty, Nabarun Jett, Marti TI Temporal Progression of Pneumonic Plague in Blood of Nonhuman Primate: A Transcriptomic Analysis SO PLOS ONE LA English DT Article ID YERSINIA-PESTIS CO92; TOLL-LIKE RECEPTORS; MOUSE MODEL; KAPPA-B; BIOLOGICAL AGENTS; IMMUNE-RESPONSE; INNATE IMMUNITY; BUBONIC PLAGUE; INFECTION; EXPRESSION AB Early identification of impending illness during widespread exposure to a pathogenic agent offers a potential means to initiate treatment during a timeframe when it would be most likely to be effective and has the potential to identify novel therapeutic strategies. The latter could be critical, especially as antibiotic resistance is becoming widespread. In order to examine pre-symptomatic illness, African green monkeys were challenged intranasally with aerosolized Yersinia pestis strain CO92 and blood samples were collected in short intervals from 45 m till 42 h post-exposure. Presenting one of the first genomic investigations of a NHP model challenged by pneumonic plague, whole genome analysis was annotated in silico and validated by qPCR assay. Transcriptomic profiles of blood showed early perturbation with the number of differentially expressed genes increasing until 24 h. By then, Y. pestis had paralyzed the host defense, as suggested by the functional analyses. Early activation of the apoptotic networks possibly facilitated the pathogen to overwhelm the defense mechanisms, despite the activation of the pro-inflammatory mechanism, toll-like receptors and microtubules at the port-of-entry. The overexpressed transcripts encoding an early pro-inflammatory response particularly manifested in active lymphocytes and ubiquitin networks were a potential deviation from the rodent models, which needs further verification. In summary, the present study recognized a pattern of Y. pestis pathogenesis potentially more applicable to the human system. Independent validation using the complementary omics approach with comprehensive evaluation of the organs, such as lungs which showed early bacterial infection, is essential. C1 [Hammamieh, Rasha; Muhie, Seid; Gautam, Aarti; Miller, Stacy-Ann; Chakraborty, Nabarun; Jett, Marti] US Army Ctr Environm Hlth Res, Ft Detrick, MD 21702 USA. [Muhie, Seid] NCI, Adv Biomed Ctr, Fredrick Natl Lab Canc Res, Frederick, MD 21702 USA. [Borschel, Richard] Walter Reed Army Med Ctr, Silver Spring, MD 20910 USA. [Gautam, Aarti; Miller, Stacy-Ann; Chakraborty, Nabarun] Geneva Fdn, Ft Detrick, MD 21702 USA. RP Hammamieh, R (reprint author), US Army Ctr Environm Hlth Res, Ft Detrick, MD 21702 USA. EM Rasha.Hammamieh1.civ@mail.mil FU Defense Threat Reduction Agency [TMTI0029_09_WR_T] FX This work was supported by Defense Threat Reduction Agency, Funding #: TMTI0029_09_WR_T received by: MJ and RH. NR 59 TC 1 Z9 1 U1 3 U2 6 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAR 22 PY 2016 VL 11 IS 3 AR e0151788 DI 10.1371/journal.pone.0151788 PG 21 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DH3OX UT WOS:000372697400043 PM 27003632 ER PT J AU Sellers, MS Lisal, M Brennan, JK AF Sellers, Michael S. Lisal, Martin Brennan, John K. TI Free-energy calculations using classical molecular simulation: application to the determination of the melting point and chemical potential of a flexible RDX model SO PHYSICAL CHEMISTRY CHEMICAL PHYSICS LA English DT Article ID SOLID-LIQUID COEXISTENCE; ATOMISTIC SIMULATION; DYNAMICS SIMULATIONS; COMPUTER-SIMULATION; PHASE COEXISTENCE; FLUID MIXTURES; IONIC LIQUIDS; HARD-SPHERES; FORCE-FIELD; INTEGRATION AB We present an extension of various free-energy methodologies to determine the chemical potential of the solid and liquid phases of a fully-flexible molecule using classical simulation. The methods are applied to the Smith-Bharadwaj atomistic potential representation of cyclotrimethylene trinitramine (RDX), a well-studied energetic material, to accurately determine the solid and liquid phase Gibbs free energies, and the melting point (T-m). We outline an efficient technique to find the absolute chemical potential and melting point of a fully-flexible molecule using one set of simulations to compute the solid absolute chemical potential and one set of simulations to compute the solid-liquid free energy difference. With this combination, only a handful of simulations are needed, whereby the absolute quantities of the chemical potentials are obtained, for use in other property calculations, such as the characterization of crystal polymorphs or the determination of the entropy. Using the LAMMPS molecular simulator, the Frenkel and Ladd and pseudo-supercritical path techniques are adapted to generate 3rd order fits of the solid and liquid chemical potentials. Results yield the thermodynamic melting point T-m = 488.75 K at 1.0 atm. We also validate these calculations and compare this melting point to one obtained from a typical superheated simulation technique. C1 [Sellers, Michael S.; Brennan, John K.] US Army, Res Lab, Weap & Mat Res Directorate, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA. [Lisal, Martin] ASCR, Lab Chem & Phys Aerosols, Inst Chem Proc Fundamentals, Vvi, Rozvojova 135-1, Prague 16502 6, Suchdol, Czech Republic. [Lisal, Martin] Univ JE Purkyne, Dept Phys, Fac Sci, Ceske Mladeze 8, Usti Nad Labem 40096, Czech Republic. RP Brennan, JK (reprint author), US Army, Res Lab, Weap & Mat Res Directorate, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA. EM john.k.brennan.civ@mail.mil RI Lisal, Martin/A-8176-2011 OI Lisal, Martin/0000-0001-8005-7143 FU ARL [W911NF-10-2-0039]; Czech Science Foundation [13-02938S]; U.S. Army Research Laboratory FX The authors are grateful to Brian C. Barnes, Joshua D. Moore, Sergey Izvekov, James P. Larentzos, and Betsy M. Rice (U.S. Army Research Laboratory) for insightful discussions. The authors also acknowledge the computational resources and PETTT software support from the Department of Defense High Performance Computing Modernization Program (HPCMP). ML acknowledges sponsorship by the ARL under Cooperative Agreement W911NF-10-2-0039, and the Czech Science Foundation under project: 13-02938S. MSS acknowledges funding through a contract appointment at the U.S. Army Research Laboratory, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and U.S. Army Research Laboratory. NR 47 TC 0 Z9 0 U1 8 U2 26 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1463-9076 EI 1463-9084 J9 PHYS CHEM CHEM PHYS JI Phys. Chem. Chem. Phys. PD MAR 21 PY 2016 VL 18 IS 11 BP 7841 EP 7850 DI 10.1039/c5cp06164d PG 10 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA DG6XP UT WOS:000372229700028 PM 26661376 ER PT J AU Lum, JS Salinas, SS Filocamo, SF AF Lum, June S. Salinas, Stephen S. Filocamo, Shaun F. TI Multifunctional coatings created using an antimicrobial polymer as a platform for titania precipitation on cotton SO JOURNAL OF APPLIED POLYMER SCIENCE LA English DT Article DE biomaterials; coatings; textiles ID DIISOPROPYL FLUOROPHOSPHATASE; LOLIGO-VULGARIS; FABRICS; MECHANISM; NANOCOMPOSITES; ENCAPSULATION; PERFORMANCE; TEXTILES; BINDING; PROTEIN AB Titania precipitation on cotton has been achieved using a commercially available antimicrobial polymer, Reputex 20. The cotton swatches precipitated with titania retain antimicrobial activity, and we have also shown the ability to encapsulate diisopropyl-fluorophosphatase (DFPase), an enzyme capable of breaking down organofluorophosphates. Cotton swatches are easily prepared and precipitation occurs at room temperature in aqueous solutions at neutral pH. Both the antimicrobial properties of Reputex 20 and the hydrolytic activity of the DFPase enzyme are retained after titania precipitation, generating a cotton material exhibiting multifunctional properties. (C) 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43199. C1 [Lum, June S.; Salinas, Stephen S.; Filocamo, Shaun F.] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA. [Salinas, Stephen S.] MIT, Cambridge, MA 02139 USA. RP Filocamo, SF (reprint author), US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA. EM shaun.f.filocamo.civ@mail.mil FU United States Army FX This work was supported by the United States Army. This research was supported in part by an appointment of J.S.L. to the Postgraduate Research Participation Program at the U.S. Army Natick Soldier Research, Development and Engineering Center administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and NSRDEC. The authors would like to thank David Ziegler for assistance with the SEM and XRD facilities at NSRDEC. Robert E. Stote II is acknowledged for helpful discussions regarding antimicrobial activity. Robert Guarino from Lonza is gratefully acknowledged for the generous donation of Reputex 20 solution. NR 40 TC 0 Z9 0 U1 6 U2 20 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0021-8995 EI 1097-4628 J9 J APPL POLYM SCI JI J. Appl. Polym. Sci. PD MAR 20 PY 2016 VL 133 IS 12 AR 43199 DI 10.1002/APP.43199 PG 12 WC Polymer Science SC Polymer Science GA DA6KP UT WOS:000367913500012 ER PT J AU Corti, D Misasi, J Mulangu, S Stanley, DA Kanekiyo, M Wollen, S Ploquin, A Doria-Rose, NA Staupe, RP Bailey, M Shi, W Choe, M Marcus, H Thompson, EA Cagigi, A Silacci, C Fernandez-Rodriguez, B Perez, L Sallusto, F Vanzetta, F Agatic, G Cameroni, E Kisalu, N Gordon, I Ledgerwood, JE Mascola, JR Graham, BS Muyembe-Tamfun, JJ Trefry, JC Lanzavecchia, A Sullivan, NJ AF Corti, Davide Misasi, John Mulangu, Sabue Stanley, Daphne A. Kanekiyo, Masaru Wollen, Suzanne Ploquin, Aurelie Doria-Rose, Nicole A. Staupe, Ryan P. Bailey, Michael Shi, Wei Choe, Misook Marcus, Hadar Thompson, Emily A. Cagigi, Alberto Silacci, Chiara Fernandez-Rodriguez, Blanca Perez, Laurent Sallusto, Federica Vanzetta, Fabrizia Agatic, Gloria Cameroni, Elisabetta Kisalu, Neville Gordon, Ingelise Ledgerwood, Julie E. Mascola, John R. Graham, Barney S. Muyembe-Tamfun, Jean-Jacques Trefry, John C. Lanzavecchia, Antonio Sullivan, Nancy J. TI Protective monotherapy against lethal Ebola virus infection by a potently neutralizing antibody SO SCIENCE LA English DT Article ID MONOCLONAL-ANTIBODIES; OUTBREAK; MONKEYS; DISEASE; ZAIRE AB Ebola virus disease in humans is highly lethal, with case fatality rates ranging from 25 to 90%. There is no licensed treatment or vaccine against the virus, underscoring the need for efficacious countermeasures. We ascertained that a human survivor of the 1995 Kikwit Ebola virus disease outbreak maintained circulating antibodies against the Ebola virus surface glycoprotein for more than a decade after infection. From this survivor we isolated monoclonal antibodies (mAbs) that neutralize recent and previous outbreak variants of Ebola virus and mediate antibody-dependent cell-mediated cytotoxicity in vitro. Strikingly, monotherapy with mAb114 protected macaques when given as late as 5 days after challenge. Treatment with a single human mAb suggests that a simplified therapeutic strategy for human Ebola infection may be possible. C1 [Corti, Davide; Silacci, Chiara; Fernandez-Rodriguez, Blanca; Perez, Laurent; Sallusto, Federica; Lanzavecchia, Antonio] Univ Svizzera Italiana, Inst Res Biomed, CH-6500 Bellinzona, Switzerland. [Corti, Davide; Vanzetta, Fabrizia; Agatic, Gloria; Cameroni, Elisabetta] Humabs BioMed SA, CH-6500 Bellinzona, Switzerland. [Misasi, John; Mulangu, Sabue; Stanley, Daphne A.; Kanekiyo, Masaru; Ploquin, Aurelie; Doria-Rose, Nicole A.; Staupe, Ryan P.; Bailey, Michael; Shi, Wei; Choe, Misook; Marcus, Hadar; Thompson, Emily A.; Cagigi, Alberto; Kisalu, Neville; Gordon, Ingelise; Ledgerwood, Julie E.; Mascola, John R.; Graham, Barney S.; Sullivan, Nancy J.] NIAID, Vaccine Res Ctr, 9000 Rockville Pike, Bethesda, MD 20892 USA. [Wollen, Suzanne; Trefry, John C.] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Kisalu, Neville; Muyembe-Tamfun, Jean-Jacques] Natl Lab Publ Hlth, Natl Inst Biomed Res, BP 1197, Kinshasa, DEM REP CONGO. [Lanzavecchia, Antonio] ETH, Inst Microbiol, CH-8093 Zurich, Switzerland. RP Sullivan, NJ (reprint author), NIAID, Vaccine Res Ctr, 9000 Rockville Pike, Bethesda, MD 20892 USA. EM njsull@mail.nih.gov RI Cagigi, Alberto/K-4824-2016 OI Cagigi, Alberto/0000-0002-3567-9514 FU Intramural Research Program of the Vaccine Research Center, National Institute of Allergy and Infectious Diseases FX We thank M. Cichanowski for graphics, B. Hartman for manuscript preparation, A. Tislerics and J. McLellan for critical reading of the manuscript, A. R. Townsend for providing EBOV-GP expressing MDCK-SIAT cells, and the study volunteers for the donation of blood for these investigations. The data reported in this manuscript are tabulated in the main paper and in the supplementary materials. Antibody sequences have been deposited in GenBank with accession numbers KU594601, KU594602, KU594603, and KU594604. Supported by the Intramural Research Program of the Vaccine Research Center, National Institute of Allergy and Infectious Diseases. N.J.S., S.M., B.S.G., J.E.L, D.A.S., J.-J.M.-T J.C.T., D.C., and A.L. are listed as inventors on patent applications related to anti-Ebola virus antibodies and their use. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Department of Defense or the U.S. Department of the Army. NR 19 TC 20 Z9 20 U1 12 U2 30 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 0036-8075 EI 1095-9203 J9 SCIENCE JI Science PD MAR 18 PY 2016 VL 351 IS 6279 BP 1339 EP 1342 DI 10.1126/science.aad5224 PG 4 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DG9JD UT WOS:000372397700047 PM 26917593 ER PT J AU Bucher, B Zhu, S Wu, CY Janssens, RVF Cline, D Hayes, AB Albers, M Ayangeakaa, AD Butler, PA Campbell, CM Carpenter, MP Chiara, CJ Clark, JA Crawford, HL Cromaz, M David, HM Dickerson, C Gregor, ET Harker, J Hoffman, CR Kay, BP Kondev, FG Korichi, A Lauritsen, T Macchiavelli, AO Pardo, RC Richard, A Riley, MA Savard, G Scheck, M Seweryniak, D Smith, MK Vondrasek, R Wiens, A AF Bucher, B. Zhu, S. Wu, C. Y. Janssens, R. V. F. Cline, D. Hayes, A. B. Albers, M. Ayangeakaa, A. D. Butler, P. A. Campbell, C. M. Carpenter, M. P. Chiara, C. J. Clark, J. A. Crawford, H. L. Cromaz, M. David, H. M. Dickerson, C. Gregor, E. T. Harker, J. Hoffman, C. R. Kay, B. P. Kondev, F. G. Korichi, A. Lauritsen, T. Macchiavelli, A. O. Pardo, R. C. Richard, A. Riley, M. A. Savard, G. Scheck, M. Seweryniak, D. Smith, M. K. Vondrasek, R. Wiens, A. TI Direct Evidence of Octupole Deformation in Neutron-Rich Ba-144 SO PHYSICAL REVIEW LETTERS LA English DT Article ID GROUND-STATE; BARIUM ISOTOPES; RADIOACTIVE BEAMS; DEFORMED-NUCLEI; PARITY; ENERGY AB The neutron-rich nucleus Ba-144 (t(1/2) = 11.5 s) is expected to exhibit some of the strongest octupole correlations among nuclei with mass numbers A less than 200. Until now, indirect evidence for such strong correlations has been inferred from observations such as enhanced E1 transitions and interleaving positive- and negative-parity levels in the ground-state band. In this experiment, the octupole strength was measured directly by sub-barrier, multistep Coulomb excitation of a post-accelerated 650-MeV Ba-144 beam on a 1.0-mg/cm(2) Pb-208 target. The measured value of the matrix element, < 3(1)(-)parallel to M(E3)parallel to 0(1)(+)> = 0.65((+17)(-23)) eb(3/2,) corresponds to a reduced Bd(E3) transition probability of 48((+25)(-34)) W.u. This result represents an unambiguous determination of the octupole collectivity, is larger than any available theoretical prediction, and is consistent with octupole deformation. C1 [Bucher, B.; Wu, C. Y.] Lawrence Livermore Natl Lab, Livermore, CA 94550 USA. [Zhu, S.; Janssens, R. V. F.; Albers, M.; Ayangeakaa, A. D.; Carpenter, M. P.; Chiara, C. J.; Clark, J. A.; David, H. M.; Dickerson, C.; Harker, J.; Hoffman, C. R.; Kay, B. P.; Kondev, F. G.; Korichi, A.; Lauritsen, T.; Pardo, R. C.; Savard, G.; Seweryniak, D.; Vondrasek, R.] Argonne Natl Lab, 9700 S Cass Ave, Argonne, IL 60439 USA. [Cline, D.; Hayes, A. B.] Univ Rochester, 601 Elmwood Ave, Rochester, NY 14627 USA. [Butler, P. A.] Univ Liverpool, Liverpool L69 7ZE, Merseyside, England. [Campbell, C. M.; Crawford, H. L.; Cromaz, M.; Macchiavelli, A. O.; Wiens, A.] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA. [Chiara, C. J.; Harker, J.] Univ Maryland, College Pk, MD 20742 USA. [Crawford, H. L.; Richard, A.] Ohio Univ, Athens, OH 45701 USA. [Gregor, E. T.; Scheck, M.] Univ West Scotland, Paisley PA1 2BE, Renfrew, Scotland. [Gregor, E. T.; Scheck, M.] SUPA, Glasgow G12 8QQ, Lanark, Scotland. [Korichi, A.] IN2P3 CNRS, CSNSM, Batiment 104-108, F-91405 Orsay, France. [Riley, M. A.] Florida State Univ, Tallahassee, FL 32306 USA. [Smith, M. K.] Univ Notre Dame, Notre Dame, IN 46556 USA. [Chiara, C. J.] US Army Res Lab, Adelphi, MD 20783 USA. [David, H. M.] GSI Helmholtzzentrum Schwerionenforsch, D-64291 Darmstadt, Germany. RP Bucher, B (reprint author), Lawrence Livermore Natl Lab, Livermore, CA 94550 USA. EM bucher3@llnl.gov RI Hoffman, Calem/H-4325-2016; Kay, Benjamin/F-3291-2011 OI Hoffman, Calem/0000-0001-7141-9827; Kay, Benjamin/0000-0002-7438-0208 FU U.S. Department of Energy, Office of Science, Office of Nuclear Physics [DE-AC02-06CH11357, DE-AC02-05CH11231, DE-AC52-07NA27344]; DOE [DE-FG02-94ER40834]; National Science Foundation [PHY-01401574, PHY-1068192]; STFC (UK) [ST/L005808/1] FX This work was funded by the U.S. Department of Energy, Office of Science, Office of Nuclear Physics, under Contract No. DE-AC02-06CH11357 (ANL), No. DE-AC02-05CH11231 (LBNL, GRETINA), No. DE-AC52-07NA27344 (LLNL), DOE Grant No. DE-FG02-94ER40834 (UM), and the National Science Foundation Grant No. PHY-01401574 (FSU) and PHY-1068192 (ND). M. S. and E. T. G. were supported by STFC (UK) Grant No. ST/L005808/1. This research used resources of ANL's ATLAS facility, which is a DOE Office of Science User Facility. NR 29 TC 11 Z9 11 U1 2 U2 8 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0031-9007 EI 1079-7114 J9 PHYS REV LETT JI Phys. Rev. Lett. PD MAR 17 PY 2016 VL 116 IS 11 AR 112503 DI 10.1103/PhysRevLett.116.112503 PG 5 WC Physics, Multidisciplinary SC Physics GA DG9VU UT WOS:000372432700004 PM 27035298 ER PT J AU Warren, TK Jordan, R Lo, MK Ray, AS Mackman, RL Soloveva, V Siegel, D Perron, M Bannister, R Hui, HC Larson, N Strickley, R Wells, J Stuthman, KS Van Tongeren, SA Garza, NL Donnelly, G Shurtleff, AC Retterer, CJ Gharaibeh, D Zamani, R Kenny, T Eaton, BP Grimes, E Welch, LS Gomba, L Wilhelmsen, CL Nichols, DK Nuss, JE Nagle, ER Kugelman, JR Palacios, G Doerffler, E Neville, S Carra, E Clarke, MO Zhang, LJ Lew, W Ross, B Wang, Q Chun, K Wolfe, L Babusis, D Park, Y Stray, KM Trancheva, I Feng, JY Barauskas, O Xu, YL Wong, P Braun, MR Flint, M McMullan, LK Chen, SS Fearns, R Swaminathan, S Mayers, DL Spiropoulou, CF Lee, WA Nichol, ST Cihlar, T Bavari, S AF Warren, Travis K. Jordan, Robert Lo, Michael K. Ray, Adrian S. Mackman, Richard L. Soloveva, Veronica Siegel, Dustin Perron, Michel Bannister, Roy Hui, Hon C. Larson, Nate Strickley, Robert Wells, Jay Stuthman, Kelly S. Van Tongeren, Sean A. Garza, Nicole L. Donnelly, Ginger Shurtleff, Amy C. Retterer, Cary J. Gharaibeh, Dima Zamani, Rouzbeh Kenny, Tara Eaton, Brett P. Grimes, Elizabeth Welch, Lisa S. Gomba, Laura Wilhelmsen, Catherine L. Nichols, Donald K. Nuss, Jonathan E. Nagle, Elyse R. Kugelman, Jeffrey R. Palacios, Gustavo Doerffler, Edward Neville, Sean Carra, Ernest Clarke, Michael O. Zhang, Lijun Lew, Willard Ross, Bruce Wang, Queenie Chun, Kwon Wolfe, Lydia Babusis, Darius Park, Yeojin Stray, Kirsten M. Trancheva, Iva Feng, Joy Y. Barauskas, Ona Xu, Yili Wong, Pamela Braun, Molly R. Flint, Mike McMullan, Laura K. Chen, Shan-Shan Fearns, Rachel Swaminathan, Swami Mayers, Douglas L. Spiropoulou, Christina F. Lee, William A. Nichol, Stuart T. Cihlar, Tomas Bavari, Sina TI Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys SO NATURE LA English DT Article ID INFECTED NONHUMAN-PRIMATES; ANTIVIRAL ACTIVITY; T-705 FAVIPIRAVIR; HIGH-THROUGHPUT; POLYMERASE; INHIBITOR; MODEL; PROTECTION; MACAQUES; PROMOTER AB The most recent Ebola virus outbreak in West Africa, which was unprecedented in the number of cases and fatalities, geographic distribution, and number of nations affected, highlights the need for safe, effective, and readily available antiviral agents for treatment and prevention of acute Ebola virus (EBOV) disease (EVD) or sequelae(1). No antiviral therapeutics have yet received regulatory approval or demonstrated clinical efficacy. Here we report the discovery of a novel small molecule GS-5734, a monophosphoramidate prodrug of an adenosine analogue, with antiviral activity against EBOV. GS-5734 exhibits antiviral activity against multiple variants of EBOV and other filoviruses in cell-based assays. The pharmacologically active nucleoside triphosphate (NTP) is efficiently formed in multiple human cell types incubated with GS-5734 in vitro, and the NTP acts as an alternative substrate and RNA-chain terminator in primer-extension assays using a surrogate respiratory syncytial virus RNA polymerase. Intravenous administration of GS-5734 to nonhuman primates resulted in persistent NTP levels in peripheral blood mononuclear cells (half-life, 14 h) and distribution to sanctuary sites for viral replication including testes, eyes, and brain. In a rhesus monkey model of EVD, once-daily intravenous administration of 10 mg kg(-1) GS-5734 for 12 days resulted in profound suppression of EBOV replication and protected 100% of EBOV-infected animals against lethal disease, ameliorating clinical disease signs and pathophysiological markers, even when treatments were initiated three days after virus exposure when systemic viral RNA was detected in two out of six treated animals. These results show the first substantive post-exposure protection by a small-molecule antiviral compound against EBOV in nonhuman primates. The broad-spectrum antiviral activity of GS-5734 in vitro against other pathogenic RNA viruses, including filoviruses, arenaviruses, and coronaviruses, suggests the potential for wider medical use. GS-5734 is amenable to large-scale manufacturing, and clinical studies investigating the drug safety and pharmacokinetics are ongoing. C1 [Warren, Travis K.; Soloveva, Veronica; Wells, Jay; Stuthman, Kelly S.; Van Tongeren, Sean A.; Garza, Nicole L.; Donnelly, Ginger; Shurtleff, Amy C.; Retterer, Cary J.; Gharaibeh, Dima; Zamani, Rouzbeh; Kenny, Tara; Eaton, Brett P.; Grimes, Elizabeth; Welch, Lisa S.; Gomba, Laura; Wilhelmsen, Catherine L.; Nichols, Donald K.; Nuss, Jonathan E.; Nagle, Elyse R.; Kugelman, Jeffrey R.; Palacios, Gustavo; Mayers, Douglas L.; Bavari, Sina] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Warren, Travis K.; Soloveva, Veronica; Gomba, Laura; Nuss, Jonathan E.; Bavari, Sina] US Army, Med Res Inst Infect Dis, Therapeut Dev Ctr, Ft Detrick, MD 21702 USA. [Jordan, Robert; Ray, Adrian S.; Mackman, Richard L.; Siegel, Dustin; Perron, Michel; Bannister, Roy; Hui, Hon C.; Larson, Nate; Strickley, Robert; Doerffler, Edward; Neville, Sean; Carra, Ernest; Clarke, Michael O.; Zhang, Lijun; Lew, Willard; Ross, Bruce; Wang, Queenie; Chun, Kwon; Wolfe, Lydia; Babusis, Darius; Park, Yeojin; Stray, Kirsten M.; Trancheva, Iva; Feng, Joy Y.; Barauskas, Ona; Xu, Yili; Wong, Pamela; Chen, Shan-Shan; Swaminathan, Swami; Lee, William A.; Cihlar, Tomas] Gilead Sci Inc, 353 Lakeside Dr, Foster City, CA 94404 USA. [Lo, Michael K.; Flint, Mike; McMullan, Laura K.; Spiropoulou, Christina F.; Nichol, Stuart T.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Braun, Molly R.; Fearns, Rachel] Boston Univ, Sch Med, Boston, MA 02118 USA. [Welch, Lisa S.] LOKET Consulting, Clarksburg, MD 20871 USA. [Mayers, Douglas L.] Cocrystal Pharma, Tucker, GA 30084 USA. RP Bavari, S (reprint author), US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.; Bavari, S (reprint author), US Army, Med Res Inst Infect Dis, Therapeut Dev Ctr, Ft Detrick, MD 21702 USA.; Cihlar, T (reprint author), Gilead Sci Inc, 353 Lakeside Dr, Foster City, CA 94404 USA. EM tomas.cihlar@gilead.com; sina.bavari.civ@mail.mil OI Palacios, Gustavo/0000-0001-5062-1938 FU Joint Science and Technology Office for Chemical and Biological Defense (JSTO-CBD) of the Defense Threat Reduction Agency (DTRA) [CB10218]; NIH [R01AI113321] FX T. Bocan, A. Duplantier, R. Panchal, and C. Kane provided scientific input. B. Norquist assisted with manuscript preparation. C. Cooper provided scientific input with human macrophage cultures for high-content image assessments. S. Tritsch and G. Gomba assisted with GS-5734 dose preparations for efficacy studies. C. Rice provided animal husbandry support services. X. Wei, W. Garner, and L. Zhong provided additional support for statistical analyses. K. Wang, K. Brendza, T. Alfredson, and L. Serafini assisted with analytical methods; S. Bondy and R. Seemayer procured key raw materials; L. Heumann, R. Polniaszeck, E. Rueden, A. Chtchemelinine, K. Brak, and B. Hoang contributed to synthesis; and Y. Zherebina helped with chiral separations. G. Lee supported the RSV antiviral assay, and G. Stepan, S. Ahmadyar, and H. Yu conducted part of the cytotoxicity testing. J. Knox contributed to polymerase modelling. A. L. Rheingold performed the X-ray crystallographic analysis (Supplementary Information). Studies at USAMRIID were in part supported by The Joint Science and Technology Office for Chemical and Biological Defense (JSTO-CBD) of the Defense Threat Reduction Agency (DTRA) under plan #CB10218. Work in the Fearns laboratory was supported by NIH R01AI113321. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the US Army or the Centers for Disease Control and Prevention, US Department of Health and Human Services. NR 37 TC 22 Z9 23 U1 10 U2 29 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0028-0836 EI 1476-4687 J9 NATURE JI Nature PD MAR 17 PY 2016 VL 531 IS 7594 BP 381 EP + DI 10.1038/nature17180 PG 19 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DG4TA UT WOS:000372064300055 PM 26934220 ER PT J AU Owolabi, G Peterson, A Habtour, E Riddick, J Coatney, M Olasumboye, A Bolling, D AF Owolabi, Gbadebo Peterson, Alex Habtour, Ed Riddick, Jaret Coatney, Michael Olasumboye, Adewale Bolling, Denzell TI Dynamic response of acrylonitrile butadiene styrene under impact loading SO INTERNATIONAL JOURNAL OF MECHANICAL AND MATERIALS ENGINEERING LA English DT Article DE Additive manufacturing; Acrylonitrile butadiene styrene; High strain rates; Dynamic response ID HIGH-STRAIN RATE; PLASTIC-DEFORMATION; TI-6AL-4V ALLOY; BEHAVIOR; RATES; POLYMERS; FAILURE; DESIGN AB Background: The goal of the study is to understand the potential energy absorption benefits ofcomponents fabricated using fused deposition modeling additive manufacturing under high strain rateloading. Methods: Tensile tests were conducted on 3-D printed acrylonitrile butadiene styrene (ABS) at differentstrain rates, according to the ASTM D638 standard, to assess its strain rate sensitivity under quasi-staticloads. The tensile test was also necessary to determine the mechanical properties necessary to characterizethe dynamic response of the ABS at high strain rates. The ABS specimens were subjected to high strainrate deformation through the use of the split Hopkinson pressure bar. Results: During compression, a new phenomenon described as a multistage collapse in which the samplesundergo multiple stages of contraction and expansion was observed as the impact load was applied. Thismultistage deformation behavior may be attributable to the ring formed around layers in the specimen dueto the manner of fabrication which potentially absorbed and released the energy, thus acting as a multistage spring. As the velocity of impact increases, it is observed that the ABS capability for energy absorption decreased to where there was only one stage of compression equivalent to the initial stage. Conclusion: The multistage collapse of the 3-D printed ABS specimen indicates a potential for a novel energy absorption mechanism to be exploited at lower strain rates. Future work in the area should include more studies about printing orientation, as well as investigating the impact of the presence of the outer cylindrical ring on the overall dynamic response. C1 [Owolabi, Gbadebo; Peterson, Alex; Olasumboye, Adewale; Bolling, Denzell] Howard Univ, Dept Mech Engn, Washington, DC 20059 USA. [Habtour, Ed; Riddick, Jaret; Coatney, Michael] US Army, Res Lab, Vehicle Technol Directorate, Aberdeen, MD USA. RP Owolabi, G (reprint author), Howard Univ, Dept Mech Engn, Washington, DC 20059 USA. EM gbadebo.owolabi@howard.edu NR 19 TC 1 Z9 1 U1 2 U2 4 PU SPRINGER SINGAPORE PTE LTD PI SINGAPORE PA #04-01 CENCON I, 1 TANNERY RD, SINGAPORE 347719, SINGAPORE SN 1823-0334 EI 2198-2791 J9 INT J MECH MATER ENG JI Int. J. Mech. Mater. Eng. PD MAR 16 PY 2016 VL 11 AR 3 DI 10.1186/s40712-016-0056-0 PG 8 WC Materials Science, Multidisciplinary SC Materials Science GA DO7QV UT WOS:000377978200001 ER PT J AU Goldschmidt, EA Boulier, T Brown, RC Koller, SB Young, JT Gorshkov, AV Rolston, SL Porto, JV AF Goldschmidt, E. A. Boulier, T. Brown, R. C. Koller, S. B. Young, J. T. Gorshkov, A. V. Rolston, S. L. Porto, J. V. TI Anomalous Broadening in Driven Dissipative Rydberg Systems SO PHYSICAL REVIEW LETTERS LA English DT Article ID ATOMS AB We observe interaction-induced broadening of the two-photon 5s-18s transition in Rb-87 atoms trapped in a 3D optical lattice. The measured linewidth increases by nearly 2 orders of magnitude with increasing atomic density and excitation strength, with corresponding suppression of resonant scattering and enhancement of off-resonant scattering. We attribute the increased linewidth to resonant dipole-dipole interactions of 18s atoms with blackbody induced population in nearby np states. Over a range of initial atomic densities and excitation strengths, the transition width is described by a single function of the steady-state density of Rydberg atoms, and the observed resonant excitation rate corresponds to that of a two-level system with the measured, rather than natural, linewidth. The broadening mechanism observed here is likely to have negative implications for many proposals with coherently interacting Rydberg atoms. C1 [Goldschmidt, E. A.] US Army Res Lab, Adelphi, MD 20783 USA. [Boulier, T.; Brown, R. C.; Koller, S. B.; Young, J. T.; Gorshkov, A. V.; Rolston, S. L.; Porto, J. V.] NIST, Joint Quantum Inst, Gaithersburg, MD 20899 USA. [Boulier, T.; Brown, R. C.; Koller, S. B.; Young, J. T.; Gorshkov, A. V.; Rolston, S. L.; Porto, J. V.] Univ Maryland, Gaithersburg, MD 20899 USA. [Gorshkov, A. V.] NIST, Joint Ctr Quantum Informat & Comp Sci, College Pk, MD 20742 USA. [Gorshkov, A. V.] Univ Maryland, College Pk, MD 20742 USA. [Brown, R. C.] NIST, Boulder, CO 80305 USA. [Koller, S. B.] Phys Tech Bundesanstalt, D-38116 Braunschweig, Germany. RP Porto, JV (reprint author), NIST, Joint Quantum Inst, Gaithersburg, MD 20899 USA.; Porto, JV (reprint author), Univ Maryland, Gaithersburg, MD 20899 USA. EM porto@umd.edu RI Brown, Roger/A-9630-2009; Gorshkov, Alexey/A-9848-2008; rolston, steven/L-5175-2013; OI Brown, Roger/0000-0002-8228-4283; Gorshkov, Alexey/0000-0003-0509-3421; rolston, steven/0000-0003-1671-4190; Goldschmidt, Elizabeth/0000-0002-6553-9731 FU NSF PIF; AFOSR; ARO; ARL-CDQI; NSF PFC at JQI FX The authors thank T. C. Killian, F. B. Dunning, A. Browaeys, M. Foss-Feig, A. Hu, R. M. Wilson, and Z. X. Gong for helpful discussions. This work was partially supported by NSF PIF, AFOSR, ARO, ARL-CDQI, and NSF PFC at JQI. NR 40 TC 15 Z9 15 U1 1 U2 5 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0031-9007 EI 1079-7114 J9 PHYS REV LETT JI Phys. Rev. Lett. PD MAR 16 PY 2016 VL 116 IS 11 AR 113001 DI 10.1103/PhysRevLett.116.113001 PG 5 WC Physics, Multidisciplinary SC Physics GA DG9VQ UT WOS:000372432300002 PM 27035299 ER PT J AU Sviatenko, LK Gorb, L Hill, FC Leszczynska, D Leszczynski, J AF Sviatenko, Liudmyla K. Gorb, Leonid Hill, Frances C. Leszczynska, Danuta Leszczynski, Jerzy TI Structure and Electrochemical Properties for Complexes of Nitrocompounds with Inorganic Ions: A Theoretical Approach SO JOURNAL OF COMPUTATIONAL CHEMISTRY LA English DT Article DE redox potential; DFT method; nitrocompounds; solvation energy; AIM theory ID 2,4,6-TRINITROTOLUENE TNT; ELECTRON-DENSITIES; ACTIVATED CARBON; HYDROGEN-BONDS; CHARGE-DENSITY; FREE-ENERGIES; OXIDATION; DEGRADATION; REDUCTION; WATER AB Reduction and oxidation (redox) reactions are widely used for removal of nitrocompounds from contaminated soil and water. Structures and redox properties for complexes of nitrocompounds, such as 2,4,6-trinitrotoluene (TNT), 2,4-dinitrotoluene (DNT), 2,4-dinitroanisole (DNAN), and 5-nitro-2,4-dihydro-3H-1,2,4-triazol-3-one (NTO), with common inorganic ions (Na+, Cl-, NO3-) were investigated at the SMD(Pauling)/PCM(Pauling)/MPWB1K/TZVP level of theory. Atoms in molecules (AIM) theory was applied to analyze the topological properties of the bond critical points involved in the interactions between the nitrocompounds and the ions. Topological analyses show that intermolecular interactions of the types O(N)center dot center dot center dot Na+, C-H center dot center dot center dot Cl- (ONO2-), and C center dot center dot center dot Cl- (ONO2-) may be discussed as noncovalent closed-shell interactions, while NH center dot center dot center dot Cl- (ONO2-) hydrogen bonds are partially covalent in nature. Complexation causes significant decrease of redox activity of the nitrocompounds. Analysis of the reduction potentials of the complexes obtained through application of the Pourbaix diagram of an iron/water system revealed that sodium complexes of NTO might be reduced by metallic iron. (C) 2016 Wiley Periodicals, Inc. C1 [Sviatenko, Liudmyla K.] Jackson State Univ, Dept Chem & Biochem, Interdisciplinary Nanotox Ctr, Jackson, MS 39217 USA. [Sviatenko, Liudmyla K.] Oles Honchar Dnipropetrovsk Natl Univ, Dept Organ Chem, UA-49010 Dnepropetrovsk, Ukraine. [Gorb, Leonid] HX5 LLC, Vicksburg, MS 39180 USA. [Hill, Frances C.] US Army, Erdc, Vicksburg, MS 39180 USA. [Leszczynska, Danuta] Jackson State Univ, Interdisciplinary Nanotox Ctr, Dept Civil & Environm Engn, Jackson, MS 39217 USA. [Leszczynski, Jerzy] Jackson State Univ, Interdisciplinary Nanotox Ctr, Dept Chem & Biochem, Jackson, MS 39217 USA. RP Leszczynski, J (reprint author), Jackson State Univ, Interdisciplinary Nanotox Ctr, Dept Chem & Biochem, Jackson, MS 39217 USA. EM jerzy@icnanotox.org FU ERDC [W912HZ-13-P-0037]; National Science Foundation [OCI-1053575]; XSEDE [DMR110088]; Mississippi Center for Supercomputer Research FX Contract grant sponsor: ERDC; Contract grant number: W912HZ-13-P-0037; Contract grant sponsor: National Science Foundation; Contract grant number: OCI-1053575; Contract grant sponsor: XSEDE; Contract grant number: DMR110088; Contract grant sponsor: Mississippi Center for Supercomputer Research NR 37 TC 0 Z9 0 U1 3 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0192-8651 EI 1096-987X J9 J COMPUT CHEM JI J. Comput. Chem. PD MAR 15 PY 2016 VL 37 IS 13 BP 1206 EP 1213 DI 10.1002/jcc.24310 PG 8 WC Chemistry, Multidisciplinary SC Chemistry GA DK1WY UT WOS:000374707000006 PM 26813584 ER PT J AU Kohrt, HE Tumeh, PC Benson, D Bhardwaj, N Brody, J Formenti, S Fox, BA Galon, J June, CH Kalos, M Kirsch, I Kleen, T Kroemer, G Lanier, L Levy, R Lyerly, HK Maecker, H Marabelle, A Melenhorst, J Miller, J Melero, I Odunsi, K Palucka, K Peoples, G Ribas, A Robins, H Robinson, W Serafini, T Sondel, P Vivier, E Weber, J Wolchok, J Zitvogel, L Disis, ML Cheever, MA AF Kohrt, Holbrook E. Tumeh, Paul C. Benson, Don Bhardwaj, Nina Brody, Joshua Formenti, Silvia Fox, Bernard A. Galon, Jerome June, Carl H. Kalos, Michael Kirsch, Ilan Kleen, Thomas Kroemer, Guido Lanier, Lewis Levy, Ron Lyerly, H. Kim Maecker, Holden Marabelle, Aurelien Melenhorst, Jos Miller, Jeffrey Melero, Ignacio Odunsi, Kunle Palucka, Karolina Peoples, George Ribas, Antoni Robins, Harlan Robinson, William Serafini, Tito Sondel, Paul Vivier, Eric Weber, Jeff Wolchok, Jedd Zitvogel, Laurence Disis, Mary L. Cheever, Martin A. CA CITN TI Immunodynamics: a cancer immunotherapy trials network review of immune monitoring in immuno-oncology clinical trials SO JOURNAL FOR IMMUNOTHERAPY OF CANCER LA English DT Review DE Immunotherapy; Biomarker; Clinical trial ID NATURAL-KILLER-CELLS; C-RECEPTOR POLYMORPHISMS; IN-SITU VACCINATION; T-CELLS; ANTI-PD-L1 ANTIBODY; BREAST-CANCER; RECOGNITION EFFICIENCY; NIVOLUMAB ANTI-PD-1; METASTATIC MELANOMA; FOLLICULAR LYMPHOMA AB The efficacy of PD-1/PD-L1 targeted therapies in addition to anti-CTLA-4 solidifies immunotherapy as a modality to add to the anticancer arsenal. Despite raising the bar of clinical efficacy, immunologically targeted agents raise new challenges to conventional drug development paradigms by highlighting the limited relevance of assessing standard pharmacokinetics (PK) and pharmacodynamics (PD). Specifically, systemic and intratumoral immune effects have not consistently correlated with standard relationships between systemic dose, toxicity, and efficacy for cytotoxic therapies. Hence, PK and PD paradigms remain inadequate to guide the selection of doses and schedules, both starting and recommended Phase 2 for immunotherapies. The promise of harnessing the immune response against cancer must also be considered in light of unique and potentially serious toxicities. Refining immune endpoints to better inform clinical trial design represents a high priority challenge. The Cancer Immunotherapy Trials Network investigators review the immunodynamic effects of specific classes of immunotherapeutic agents to focus immune assessment modalities and sites, both systemic and importantly intratumoral, which are critical to the success of the rapidly growing field of immuno-oncology. C1 [Kohrt, Holbrook E.] Stanford Univ, Med Ctr, Stanford Canc Inst, Div Oncol, 269 Campus Dr,CCSR 1105, Stanford, CA 94305 USA. [Tumeh, Paul C.] Univ Calif Los Angeles, Dept Med, Div Dermatol, Los Angeles, CA 90024 USA. [Benson, Don] Ohio State Univ, Div Hematol Oncol, Columbus, OH 43210 USA. [Bhardwaj, Nina] Mt Sinai Hosp, Med Hematol & Med Oncol, New York, NY 10029 USA. [Brody, Joshua] Mt Sinai Hosp, Ruttenberg Treatment Ctr, Med Hematol & Med Oncol, New York, NY 10029 USA. [Formenti, Silvia] New York Weill Cornell Med Ctr, Dept Radiat Oncol, New York, NY USA. [Fox, Bernard A.] OHSU Canc Inst, Lab Mol & Tumor Immunol, SOM Mol Microbiol & Immunol Dept, Portland, OR USA. [Galon, Jerome] INSERM, Integrat Canc Immunol Team, Cordeliers Res Ctr, Paris, France. [June, Carl H.] Univ Penn, Perelman Sch Med, Pathol & Lab Med, Philadelphia, PA 19104 USA. [Kalos, Michael] Eli Lilly & Co, Canc Immunobiol, New York, NY USA. [Kirsch, Ilan] Adapt Biotechnol Corp, Translat Med, Seattle, WA USA. [Kleen, Thomas] Epiontis GmbH, Immune Monitoring, Berlin, Germany. [Kroemer, Guido] Univ Paris 05, Fac Med, Paris, France. [Lanier, Lewis] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA. [Levy, Ron] Stanford Sch Med, Div Oncol, Stanford, CA USA. [Lyerly, H. Kim] Duke Univ, Sch Med, Durham, NC USA. [Maecker, Holden] Stanford Canc Inst, Human Immune Monitoring Ctr Shared Resource, Stanford, CA USA. [Marabelle, Aurelien] Leon Berard Canc Ctr, Lyon, France. [Melenhorst, Jos] Smilow Ctr Translat Res, Prod Dev & Correlat Sci, Philadelphia, PA USA. [Miller, Jeffrey] Univ Minnesota, Div Hematol Expt Therapeut, Oncol & Transplantat, Minneapolis, MN USA. [Melero, Ignacio] Univ Navarra, Ctr Invest Med Aplicada, E-31080 Pamplona, Spain. [Odunsi, Kunle] Roswell Pk Canc Inst, Ctr Immunotherapy, Buffalo, NY 14263 USA. [Palucka, Karolina] Baylor Inst Immunol Res, Dallas, TX USA. [Peoples, George] Brooke Army Med Ctr, Canc Vaccine Dev Program, Houston, TX USA. [Ribas, Antoni] Univ Calif Los Angeles, Tumor Immunol Program Area Jonsson Comprehens Ctr, Los Angeles, CA USA. [Robins, Harlan] Adapt Biotechnol, Seattle, WA USA. [Robinson, William] Stanford Univ, Sch Med, Dept Med, Div Immunol & Rheumatol, Stanford, CA 94305 USA. [Serafini, Tito] Atreca Inc, Redwood City, CA USA. [Sondel, Paul] Univ Wisconsin, Cellular & Mol Pathol Grad Program, Madison, WI USA. [Vivier, Eric] Ctr Immunol Marseille Luminy, Marseille, France. [Weber, Jeff] Univ S Florida, H Lee Moffitt Canc Ctr, Tampa, FL 33682 USA. [Wolchok, Jedd] Mem Sloan Kettering Canc Ctr, Immunol Program, 1275 York Ave, New York, NY 10021 USA. [Zitvogel, Laurence] Inst GrustaveRoussy, Inst Natl Sante & Rech Med, Villejuif, France. [Disis, Mary L.] Univ Washington, Tumor Vaccine Grp, Seattle, WA 98195 USA. [Cheever, Martin A.] Fred Hutchinson Canc Res Ctr, 1100 Eastlake Ave N,E3-300,POB 19024, Seattle, WA 98109 USA. RP Cheever, MA (reprint author), Fred Hutchinson Canc Res Ctr, 1100 Eastlake Ave N,E3-300,POB 19024, Seattle, WA 98109 USA. EM mcheever@fredhutch.org OI MELERO BERMEJO, IGNACIO/0000-0002-1360-348X FU NCI NIH HHS [P30 CA124435, R35 CA197078, P30 CA008748, P50 CA159981] NR 124 TC 7 Z9 8 U1 9 U2 19 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 2051-1426 J9 J IMMUNOTHER CANCER JI J. Immunother. Cancer PD MAR 15 PY 2016 VL 4 AR 15 DI 10.1186/s40425-016-0118-0 PG 16 WC Oncology SC Oncology GA DH1LI UT WOS:000372545100004 PM 26981245 ER PT J AU Leon, LR AF Leon, Lisa R. TI Common mechanisms for the adaptive responses to exercise and heat stress SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Editorial Material ID ENDOTOXEMIA C1 [Leon, Lisa R.] US Army, Environm Med Res Inst, Thermal & Mt Med Div, Kansas St,Bldg 42, Natick, MA 01760 USA. RP Leon, LR (reprint author), US Army, Environm Med Res Inst, Thermal & Mt Med Div, Kansas St,Bldg 42, Natick, MA 01760 USA. EM lisa.r.leon.civ@mail.mil NR 13 TC 0 Z9 0 U1 2 U2 4 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 EI 1522-1601 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD MAR 15 PY 2016 VL 120 IS 6 BP 662 EP 663 DI 10.1152/japplphysiol.00113.2016 PG 2 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA DG4RU UT WOS:000372061000016 PM 26869706 ER PT J AU Tecson, KM Silver, MA Brune, SD Cauthen, C Kwan, MD Schussler, JM Vasudevan, A Watts, JA McCullough, PA AF Tecson, Kristen M. Silver, Marc A. Brune, Sonja D. Cauthen, Clay Kwan, Michael D. Schussler, Jeffrey M. Vasudevan, Anupama Watts, James A. McCullough, Peter A. TI Impact of Enhanced External Counterpulsation on Heart Failure Rehospitalization in Patients With Ischemic Cardiomyopathy SO AMERICAN JOURNAL OF CARDIOLOGY LA English DT Article ID ASSOCIATION; DISEASE; UPDATE AB Heart failure (HF) affects millions of Americans and causes financial burdens because of the need for rehospitalization. For this reason, health care systems and patients alike are seeking methods to decrease readmissions. We assessed the potential for reducing readmissions of patients with postacute care HF through an educational program combined with enhanced external counterpulsation (EECP). We examined 99 patients with HF who were referred to EECP centers and received heart failure education and EECP treatment within 90 days of hospital discharge from March 2013 to January 2015. We compared observed and predicted 90-day readmission rates and examined results of 6-minute walk tests, Duke Activity Status Index, New York Heart Association classification, and Canadian Cardiovascular Society classification before and after EECP. Patients were treated with EECP at a median augmentation pressure of 280 mm Hg (quartile 1 = 240, quartile 3 = 280), achieved as early as the first treatment. Augmentation ratios varied from 0.4 to 1.9, with a median of 1.0 (quartile 1 = 0.8, quartile 3 = 1.2). Only 6 patients (6.1%) had unplanned readmissions compared to the predicted 34%, p <0.0001. The average increase in distance walked was 52 m (18.4%), and the median increase in Duke Activity Status Index was 9.95 points (100%), p values <0.0001. New York Heart Association and Canadian Cardiovascular Society classes improved in 61% and 60% of the patients, respectively. In conclusion, patients with HF who received education and EECP within 90 days of discharge had significantly lower readmission rates than predicted, and improved functional status, walk distance, and symptoms. (c) 2016 Elsevier Inc. All rights reserved. C1 [Tecson, Kristen M.; Vasudevan, Anupama; McCullough, Peter A.] Baylor Univ, Med Ctr, Baylor Heart & Vasc Inst, Dallas, TX USA. [Silver, Marc A.] Advocate Christ Med Ctr, Dept Med, Oak Lawn, IL USA. [Brune, Sonja D.] UT Med, UT Med Cardiol, San Antonio, TX USA. [Cauthen, Clay] Seton Heart Inst, Dell Med Sch, Austin, TX USA. [Kwan, Michael D.] MHS Hlth, Adv Heart Failure & Cardiac Transplant Program, San Antonio, TX USA. [Schussler, Jeffrey M.; McCullough, Peter A.] Baylor Univ, Med Ctr, Div Cardiol, Dallas, TX USA. [Watts, James A.] Brooke Army Med Ctr, Div Cardiol, San Antonio, TX USA. [McCullough, Peter A.] Baylor Jack & Jane Hamilton Heart & Vasc Hosp, Div Cardiol, Dallas, TX USA. [McCullough, Peter A.] Heart Hosp Baylor Plano, Div Cardiol, Plano, TX USA. RP McCullough, PA (reprint author), Baylor Univ, Med Ctr, Baylor Heart & Vasc Inst, Dallas, TX USA.; McCullough, PA (reprint author), Baylor Univ, Med Ctr, Div Cardiol, Dallas, TX USA.; McCullough, PA (reprint author), Baylor Jack & Jane Hamilton Heart & Vasc Hosp, Div Cardiol, Dallas, TX USA.; McCullough, PA (reprint author), Heart Hosp Baylor Plano, Div Cardiol, Plano, TX USA. EM peteramccullough@gmail.com OI Watts, James/0000-0003-1118-838X FU Baylor Foundation; Legacy (Trinity) Heart Care FX This work was funded by the Baylor Foundation and Legacy (Trinity) Heart Care. NR 17 TC 0 Z9 0 U1 3 U2 3 PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC PI BRIDGEWATER PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA SN 0002-9149 EI 1879-1913 J9 AM J CARDIOL JI Am. J. Cardiol. PD MAR 15 PY 2016 VL 117 IS 6 BP 901 EP 905 DI 10.1016/j.amjcard.2015.12.024 PG 5 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA DG5RH UT WOS:000372135800004 PM 26813739 ER PT J AU Rasmussen, TE Crowder, AT AF Rasmussen, Todd E. Crowder, Alicia T. TI Synergy in Science and Resources SO JOURNAL OF NEUROTRAUMA LA English DT Editorial Material C1 [Rasmussen, Todd E.; Crowder, Alicia T.] US Army, Med Res & Mat Command, United States Combat Casualty Care Res Program, Ft Detrick, MD USA. [Rasmussen, Todd E.] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, Bethesda, MD 20814 USA. RP Rasmussen, TE (reprint author), United States Combat Casualty Care Res Program, 504 Scott St, Ft Detrick, MD 21702 USA. EM todd.e.rasmussen.mil@mail.mil NR 2 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD MAR 15 PY 2016 VL 33 IS 6 BP 511 EP 512 DI 10.1089/neu.2016.29007.ter PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA DG6HN UT WOS:000372184800001 PM 26982882 ER PT J AU Kochanek, PM Bramlett, HM Dixon, CE Shear, DA Dietrich, WD Schmid, KE Mondello, S Wang, KKW Hayes, RL Povlishock, JT Tortella, FC AF Kochanek, Patrick M. Bramlett, Helen M. Dixon, C. Edward Shear, Deborah A. Dietrich, W. Dalton Schmid, Kara E. Mondello, Stefania Wang, Kevin K. W. Hayes, Ronald L. Povlishock, John T. Tortella, Frank C. TI Approach to Modeling, Therapy Evaluation, Drug Selection, and Biomarker Assessments for a Multicenter Pre-Clinical Drug Screening Consortium for Acute Therapies in Severe Traumatic Brain Injury: Operation Brain Trauma Therapy SO JOURNAL OF NEUROTRAUMA LA English DT Article DE therapy; rat; penetrating ballistic-like brain injury; biomarker; micropig; controlled cortical impact; fluid percussion; neuroprotection ID CONTROLLED CORTICAL IMPACT; TIME-DEPENDENT CHANGES; SEVERE HEAD-INJURY; HEMORRHAGIC-SHOCK; RAT MODEL; CEREBROSPINAL-FLUID; CONTROLLED-TRIAL; MICE; DAMAGE; AMANTADINE AB Traumatic brain injury (TBI) was the signature injury in both the Iraq and Afghan wars and the magnitude of its importance in the civilian setting is finally being recognized. Given the scope of the problem, new therapies are needed across the continuum of care. Few therapies have been shown to be successful. In severe TBI, current guidelines-based acute therapies are focused on the reduction of intracranial hypertension and optimization of cerebral perfusion. One factor considered important to the failure of drug development and translation in TBI relates to the recognition that TBI is extremely heterogeneous and presents with multiple phenotypes even within the category of severe injury. To address this possibility and attempt to bring the most promising therapies to clinical trials, we developed Operation Brain Trauma Therapy (OBTT), a multicenter, pre-clinical drug screening consortium for acute therapies in severe TBI. OBTT was developed to include a spectrum of established TBI models at experienced centers and assess the effect of promising therapies on both conventional outcomes and serum biomarker levels. In this review, we outline the approach to TBI modeling, evaluation of therapies, drug selection, and biomarker assessments for OBTT, and provide a framework for reports in this issue on the first five therapies evaluated by the consortium. C1 [Kochanek, Patrick M.] Univ Pittsburgh, Sch Med, Safar Ctr Resuscitat Res, Dept Crit Care Med, 3434 Fifth Ave, Pittsburgh, PA 15260 USA. [Bramlett, Helen M.] Univ Miami, Miller Sch Med, Dept Neurol Surg, Miami Project Cure Paralysis, Miami, FL 33136 USA. [Bramlett, Helen M.] Vet Affairs Med Ctr, Bruce W Carter Dept, Miami, FL 33125 USA. [Dixon, C. Edward] Univ Pittsburgh, Sch Med, Brain Trauma Res Ctr, Dept Neurol Surg, Pittsburgh, PA 15260 USA. [Shear, Deborah A.] Walter Reed Army Inst Res, Ctr Excellence Psychiat & Neurosci, Brain Trauma Neuroprotect & Neurorestorat Branch, In Vivo Neuroprotect Labs, Silver Spring, MD USA. [Dietrich, W. Dalton] Univ Miami, Miller Sch Med, Dept Neurol Surg, Miami Project Cure Paralysis, Miami, FL 33136 USA. [Dietrich, W. Dalton] Univ Miami, Miller Sch Med, Dept Neurol, Miami, FL 33136 USA. [Dietrich, W. Dalton] Univ Miami, Miller Sch Med, Dept Cell Biol, Miami, FL 33136 USA. [Schmid, Kara E.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect & Neurorestorat Dept, Silver Spring, MD USA. [Mondello, Stefania] Univ Messina, Dept Neurosci, Messina, Italy. [Wang, Kevin K. W.] Univ Florida, Dept Psychiat & Neurosci, Ctr Neuroprote & Biomarkers Res, Gainesville, FL USA. [Hayes, Ronald L.] Banyan Biomarkers Inc, Ctr Neuroprote & Biomarkers, Ctr Innovat Res, Alachua, FL USA. [Povlishock, John T.] Virginia Commonwealth Univ, Dept Anat & Neurobiol, Richmond, VA USA. [Tortella, Frank C.] Walter Reed Army Inst Res, Dept Appl Neurobiol, Silver Spring, MD USA. [Tortella, Frank C.] Walter Reed Army Inst Res, Combat Casualty Care Res Program Brain Trauma & N, Silver Spring, MD USA. RP Kochanek, PM (reprint author), Univ Pittsburgh, Sch Med, Safar Ctr Resuscitat Res, Dept Crit Care Med, 3434 Fifth Ave, Pittsburgh, PA 15260 USA. EM kochanekpm@ccm.upmc.edu NR 67 TC 10 Z9 10 U1 6 U2 11 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD MAR 15 PY 2016 VL 33 IS 6 BP 513 EP 522 DI 10.1089/neu.2015.4113 PG 10 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA DG6HN UT WOS:000372184800002 PM 26439468 ER PT J AU Shear, DA Dixon, CE Bramlett, HM Mondello, S Dietrich, WD Deng-Bryant, Y Schmid, KE Wang, KKW Hayes, RL Povlishock, JT Kochanek, PM Tortella, FC AF Shear, Deborah A. Dixon, C. Edward Bramlett, Helen M. Mondello, Stefania Dietrich, W. Dalton Deng-Bryant, Ying Schmid, Kara E. Wang, Kevin K. W. Hayes, Ronald L. Povlishock, John T. Kochanek, Patrick M. Tortella, Frank C. TI Nicotinamide Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy SO JOURNAL OF NEUROTRAUMA LA English DT Article DE therapy; fluid percussion; rat; biomarker; vitamin B; neuroprotection; penetrating ballistic-like brain injury; controlled cortical impact ID FOCAL CEREBRAL-ISCHEMIA; IMPROVES FUNCTIONAL RECOVERY; CORTICAL CONTUSION INJURY; FLUID PERCUSSION INJURY; INFARCT VOLUME; WISTAR RATS; HYPOTHERMIA THERAPY; DELAYED TREATMENT; MODEL; PRECURSOR AB Nicotinamide (vitamin B-3) was the first drug selected for cross-model testing by the Operation Brain Trauma Therapy (OBTT) consortium based on a compelling record of positive results in pre-clinical models of traumatic brain injury (TBI). Adult male Sprague-Dawley rats were exposed to either moderate fluid percussion injury (FPI), controlled cortical impact injury (CCI), or penetrating ballistic-like brain injury (PBBI). Nicotinamide (50 or 500 mg/kg) was delivered intravenously at 15 min and 24 h after injury with subsequent behavioral, biomarker, and histopathological outcome assessments. There was an intermediate effect on balance beam performance with the high (500 mg/kg) dose in the CCI model, but no significant therapeutic benefit was detected on any other motor task across the OBTT TBI models. There was an intermediate benefit on working memory with the high dose in the FPI model. A negative effect of the low (50 mg/kg) dose, however, was observed on cognitive outcome in the CCI model, and no cognitive improvement was observed in the PBBI model. Lesion volume analysis showed no treatment effects after either FPI or PBBI, but the high dose of nicotinamide resulted in significant tissue sparing in the CCI model. Biomarker assessments included measurements of glial fibrillary acidic protein (GFAP) and ubiquitin carboxyl-terminal hydrolase-1 (UCH-L1) in blood at 4 or 24 h after injury. Negative effects (both doses) were detected on biomarker levels of GFAP after FPI and on biomarker levels of UCH-L1 after PBBI. The high dose of nicotinamide, however, reduced GFAP levels after both PBBI and CCI. Overall, our results showed a surprising lack of benefit from the low dose nicotinamide. In contrast, and partly in keeping with the literature, some benefit was achieved with the high dose. The marginal benefits achieved with nicotinamide, however, which appeared sporadically across the TBI models, has reduced enthusiasm for further investigation by the OBTT Consortium. C1 [Shear, Deborah A.; Deng-Bryant, Ying; Schmid, Kara E.; Tortella, Frank C.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect Neurorestorat, Silver Spring, MD USA. [Dixon, C. Edward] Univ Pittsburgh, Sch Med, Brain Trauma Res Ctr, Dept Neurol Surg, Pittsburgh, PA 15260 USA. [Bramlett, Helen M.; Dietrich, W. Dalton] Univ Miami, Miller Sch Med, Miami Project Cure Paralysis, Dept Neurol Surg, Miami, FL 33136 USA. [Bramlett, Helen M.] Vet Affairs Med Ctr, Bruce W Carter Dept, Miami, FL 33125 USA. [Mondello, Stefania] Univ Messina, Dept Neurosci, Messina, Italy. [Wang, Kevin K. W.] Univ Florida, Dept Psychiat & Neurosci, Ctr Neuroprote & Biomarkers Res, Gainesville, FL USA. [Hayes, Ronald L.] Banyan Biomarkers Inc, Ctr Neuroprote & Biomarkers Res, Ctr Innovat Res, Alachua, FL USA. [Povlishock, John T.] Virginia Commonwealth Univ, Dept Anat & Neurobiol, Richmond, VA USA. [Kochanek, Patrick M.] Univ Pittsburgh, Sch Med, Safar Ctr Resuscitat Res, Dept Crit Care Med, 3434 Fifth Ave, Pittsburgh, PA 15260 USA. RP Kochanek, PM (reprint author), Univ Pittsburgh, Sch Med, Safar Ctr Resuscitat Res, Dept Crit Care Med, 3434 Fifth Ave, Pittsburgh, PA 15260 USA. EM kochanekpm@ccm.upmc.edu NR 42 TC 7 Z9 8 U1 2 U2 6 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD MAR 15 PY 2016 VL 33 IS 6 BP 523 EP 537 DI 10.1089/neu.2015.4115 PG 15 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA DG6HN UT WOS:000372184800003 PM 26670792 ER PT J AU Bramlett, HM Dietrich, WD Dixon, CE Shear, DA Schmid, KE Mondello, S Wang, KKW Hayes, RL Povlishock, JT Tortella, FC Kochanek, PM AF Bramlett, Helen M. Dietrich, W. Dalton Dixon, C. Edward Shear, Deborah A. Schmid, Kara E. Mondello, Stefania Wang, Kevin K. W. Hayes, Ronald L. Povlishock, John T. Tortella, Frank C. Kochanek, Patrick M. TI Erythropoietin Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy SO JOURNAL OF NEUROTRAUMA LA English DT Article DE penetrating ballistic-like brain injury; fluid percussion; biomarker; neuroprotection; rat; controlled cortical impact; therapy ID RECOMBINANT-HUMAN-ERYTHROPOIETIN; NRF2 SIGNALING PATHWAY; CORTICAL IMPACT INJURY; FUNCTIONAL RECOVERY; MIMETIC PEPTIDE; RAT-BRAIN; MODEL; MICE; GENE; TISSUE AB Experimental studies targeting traumatic brain injury (TBI) have reported that erythropoietin (EPO) is an endogenous neuroprotectant in multiple models. In addition to its neuroprotective effects, it has also been shown to enhance reparative processes including angiogenesis and neurogenesis. Based on compelling pre-clinical data, EPO was tested by the Operation Brain Trauma Therapy (OBTT) consortium to evaluate therapeutic potential in multiple TBI models along with biomarker assessments. Based on the pre-clinical TBI literature, two doses of EPO (5000 and 10,000 IU/kg) were tested given at 15 min after moderate fluid percussion brain injury (FPI), controlled cortical impact (CCI), or penetrating ballistic-like brain injury (PBBI) with subsequent behavioral, histopathological, and biomarker outcome assessments. There was a significant benefit on beam walk with the 5000 IU dose in CCI, but no benefit on any other motor task across models in OBTT. Also, no benefit of EPO treatment across the three TBI models was noted using the Morris water maze to assess cognitive deficits. Lesion volume analysis showed no treatment effects after either FPI or CCI; however, with the 5000 IU/kg dose of EPO, a paradoxical increase in lesion volume and percent hemispheric tissue loss was seen after PBBI. Biomarker assessments included measurements of glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase-L1 (UCH-L1) in blood at 4 or 24 h after injury. No treatment effects were seen on biomarker levels after FPI, whereas treatment at either dose exacerbated the increase in GFAP at 24 h in PBBI but attenuated 24-4 h delta UCH-L1 levels at high dose in CCI. Our data indicate a surprising lack of efficacy of EPO across three established TBI models in terms of behavioral, histopathological, and biomarker assessments. Although we cannot rule out the possibility that other doses or more prolonged treatment could show different effects, the lack of efficacy of EPO reduced enthusiasm for its further investigation in OBTT. C1 [Bramlett, Helen M.; Dietrich, W. Dalton] Univ Miami, Miller Sch Med, Dept Neurol Surg, Miami Project Cure Paralysis, Miami, FL 33136 USA. [Bramlett, Helen M.] Vet Affairs Med Ctr, Bruce W Carter Dept, Miami, FL 33125 USA. [Dixon, C. Edward] Univ Pittsburgh, Sch Med, Brain Trauma Res Ctr, Dept Neurol Surg, Pittsburgh, PA 15260 USA. [Shear, Deborah A.; Schmid, Kara E.; Tortella, Frank C.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect Neurorestorat, Silver Spring, MD USA. [Mondello, Stefania] Univ Messina, Dept Neurosci, Messina, Italy. [Wang, Kevin K. W.] Univ Florida, Dept Psychiat & Neurosci, Ctr Neuroprote & Biomarkers Res, Gainesville, FL USA. [Hayes, Ronald L.] Banyan Biomarkers Inc, Ctr Neuroprote & Biomarkers Res, Ctr Innovat Res, Alachua, FL USA. [Povlishock, John T.] Virginia Commonwealth Univ, Dept Anat & Neurobiol, Richmond, VA USA. [Kochanek, Patrick M.] Univ Pittsburgh, Sch Med, Safar Ctr Resuscitat Res, Dept Crit Care Med, 3434 Fifth Ave, Pittsburgh, PA 15260 USA. RP Kochanek, PM (reprint author), Univ Pittsburgh, Sch Med, Safar Ctr Resuscitat Res, Dept Crit Care Med, 3434 Fifth Ave, Pittsburgh, PA 15260 USA. EM kochanekpm@ccm.upmc.edu NR 48 TC 5 Z9 5 U1 2 U2 3 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD MAR 15 PY 2016 VL 33 IS 6 BP 538 EP 552 DI 10.1089/neu.2015.4116 PG 15 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA DG6HN UT WOS:000372184800004 PM 26670694 ER PT J AU Dixon, CE Bramlett, HM Dietrich, WD Shear, DA Yan, HQ Deng-Bryant, Y Mondello, S Wang, KKW Hayes, RL Empey, PE Povlishock, JT Tortella, FC Kochanek, PM AF Dixon, C. Edward Bramlett, Helen M. Dietrich, W. Dalton Shear, Deborah A. Yan, Hong Q. Deng-Bryant, Ying Mondello, Stefania Wang, Kevin K. W. Hayes, Ronald L. Empey, Philip E. Povlishock, John T. Tortella, Frank C. Kochanek, Patrick M. TI Cyclosporine Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy SO JOURNAL OF NEUROTRAUMA LA English DT Article DE therapy; rat; biomarker; fluid percussion; calcineurin; neuroprotection; controlled cortical impact; penetrating ballistic-like brain injury; phosphatase ID MITOCHONDRIAL PERMEABILITY TRANSITION; HYPOTHERMIA THERAPY; DOSE-RESPONSE; AXONAL INJURY; RATS; DAMAGE; MODEL; NIM811; MOTOR AB Operation Brain Trauma Therapy (OBTT) is a consortium of investigators using multiple pre-clinical models of traumatic brain injury (TBI) to bring acute therapies to clinical trials. To screen therapies, we used three rat models (parasagittal fluid percussion injury [FPI], controlled cortical impact [CCI], and penetrating ballistic-like brain injury [PBBI]). We report results of the third therapy (cyclosporin-A; cyclosporine; [CsA]) tested by OBTT. At each site, rats were randomized to treatment with an identical regimen (TBI + vehicle, TBI + CsA [10 mg/kg], or TBI + CsA [20 mg/kg] given intravenously at 15 min and 24 h after injury, and sham). We assessed motor and Morris water maze (MWM) tasks over 3 weeks after TBI and lesion volume and hemispheric tissue loss at 21 days. In FPI, CsA (10 mg/kg) produced histological protection, but 20 mg/kg worsened working memory. In CCI, CsA (20 mg/kg) impaired MWM performance; surprisingly, neither dose showed benefit on any outcome. After PBBI, neither dose produced benefit on any outcome, and mortality was increased (20 mg/kg) partly caused by the solvent vehicle. In OBTT, CsA produced complex effects with histological protection at the lowest dose in the least severe model (FPI), but only deleterious effects as model severity increased (CCI and PBBI). Biomarker assessments included measurements of glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase-L1 (UCH-L1) in blood at 4 or 24 h after injury. No positive treatment effects were seen on biomarker levels in any of the models, whereas significant increases in 24 h UCH-L1 levels were seen with CsA (20 mg/kg) after CCI and 24 h GFAP levels in both CsA treated groups in the PBBI model. Lack of behavioral protection in any model, indicators of toxicity, and a narrow therapeutic index reduce enthusiasm for clinical translation. C1 [Dixon, C. Edward; Yan, Hong Q.] Univ Pittsburgh, Sch Med, Brain Trauma Res Ctr, Dept Neurol Surg, Pittsburgh, PA 15260 USA. [Bramlett, Helen M.; Dietrich, W. Dalton] Univ Miami, Miller Sch Med, Miami Project Cure Paralysis, Dept Neurol Surg, Miami, FL 33136 USA. [Bramlett, Helen M.] Vet Affairs Med Ctr, Bruce W Carter Dept, Miami, FL 33125 USA. [Shear, Deborah A.; Deng-Bryant, Ying; Tortella, Frank C.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect Neurorestorat, Silver Spring, MD USA. [Mondello, Stefania] Univ Messina, Dept Neurosci, Messina, Italy. [Wang, Kevin K. W.] Univ Florida, Dept Psychiat & Neurosci, Ctr Neuroprote & Biomarkers Res, Gainesville, FL USA. [Hayes, Ronald L.] Banyan Biomarkers Inc, Ctr Neuroprote & Biomarkers Res, Ctr Innovat Res, Alachua, FL USA. [Empey, Philip E.] Univ Pittsburgh, Sch Pharm, Ctr Pharmaceut Sci, Pittsburgh, PA 15260 USA. [Povlishock, John T.] Virginia Commonwealth Univ, Dept Anat & Neurobiol, Richmond, VA USA. [Kochanek, Patrick M.] Univ Pittsburgh, Sch Med, Safar Ctr Resuscitat Res, Dept Crit Care Med, 3434 Fifth Ave, Pittsburgh, PA 15260 USA. RP Kochanek, PM (reprint author), Univ Pittsburgh, Sch Med, Safar Ctr Resuscitat Res, Dept Crit Care Med, 3434 Fifth Ave, Pittsburgh, PA 15260 USA. EM kochanekpm@ccm.upmc.edu NR 38 TC 4 Z9 5 U1 1 U2 7 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD MAR 15 PY 2016 VL 33 IS 6 BP 553 EP 566 DI 10.1089/neu.2015.4122 PG 14 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA DG6HN UT WOS:000372184800005 PM 26671075 ER PT J AU Mountney, A Bramlett, HM Dixon, CE Mondello, S Dietrich, WD Wang, KKW Caudle, K Empey, PE Poloyac, SM Hayes, RL Povlishock, JT Tortella, FC Kochanek, PM Shear, DA AF Mountney, Andrea Bramlett, Helen M. Dixon, C. Edward Mondello, Stefania Dietrich, W. Dalton Wang, Kevin K. W. Caudle, Krista Empey, Philip E. Poloyac, Samuel M. Hayes, Ronald L. Povlishock, John T. Tortella, Frank C. Kochanek, Patrick M. Shear, Deborah A. TI Simvastatin Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy SO JOURNAL OF NEUROTRAUMA LA English DT Article DE penetrating ballistic-like brain injury; therapy; micropig; biomarker; controlled cortical impact; neuroprotection; statin; fluid percussion; rat ID EXPERIMENTAL INTRACEREBRAL HEMORRHAGE; ANEURYSMAL SUBARACHNOID HEMORRHAGE; COA REDUCTASE INHIBITOR; COMBINATION THERAPY; COGNITIVE DEFICITS; NEURONAL SURVIVAL; GENE-EXPRESSION; RAT; STATINS; MODEL AB Simvastatin, the fourth drug selected for testing by Operation Brain Trauma Therapy (OBTT), is a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor used clinically to reduce serum cholesterol. In addition, simvastatin has demonstrated potent antineuroinflammatory and brain edema reducing effects and has shown promise in promoting functional recovery in pre-clinical models of traumatic brain injury (TBI). The purpose of this study was to assess the potential neuroprotective effects of oral administration of simvastatin on neurobehavioral, biomarker, and histopathological outcome measures compared across three pre-clinical TBI animal models. Adult male Sprague-Dawley rats were exposed to either moderate fluid percussion injury (FPI), controlled cortical impact injury (CCI), or penetrating ballistic-like brain injury (PBBI). Simvastatin (1 or 5 mg/kg) was delivered via oral gavage at 3 h post-injury and continued once daily out to 14 days post-injury. Results indicated an intermediate beneficial effect of simvastatin on motor performance on the gridwalk (FPI), balance beam (CCI), and rotarod tasks (PBBI). No significant therapeutic benefit was detected, however, on cognitive outcome across the OBTT TBI models. In fact, Morris water maze (MWM) performance was actually worsened by treatment in the FPI model and scored full negative points for low dose in the MWM latency and swim distance to locate the hidden platform. A detrimental effect on cortical tissue loss was also seen in the FPI model, and there were no benefits on histology across the other models. Simvastatin also produced negative effects on circulating glial fibrillary acidic protein biomarker outcomes that were evident in the FPI and PBBI models. Overall, the current findings do not support the beneficial effects of simvastatin administration over 2 weeks post-TBI using the oral route of administration and, as such, it will not be further pursued by OBTT. C1 [Mountney, Andrea; Caudle, Krista; Tortella, Frank C.; Shear, Deborah A.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect Neurorestorat, Silver Spring, MD USA. [Bramlett, Helen M.; Dietrich, W. Dalton] Univ Miami, Miller Sch Med, Miami Project Cure Paralysis, Dept Neurol Surg, Miami, FL 33136 USA. [Bramlett, Helen M.; Dietrich, W. Dalton] Vet Affairs Med Ctr, Bruce W Carter Dept, Miami, FL 33125 USA. [Dixon, C. Edward] Univ Pittsburgh, Sch Med, Brain Trauma Res Ctr, Dept Neurol Surg, Pittsburgh, PA 15260 USA. [Mondello, Stefania] Univ Messina, Dept Neurosci, Messina, Italy. [Wang, Kevin K. W.] Univ Florida, Dept Psychiat & Neurosci, Ctr Neuroprote & Biomarkers Res, Gainesville, FL USA. [Empey, Philip E.; Poloyac, Samuel M.] Univ Pittsburgh, Sch Pharm, Pittsburgh, PA 15260 USA. [Hayes, Ronald L.] Banyan Biomarkers Inc, Ctr Neuroprote & Biomarkers Res, Ctr Innovat Res, Alachua, FL USA. [Povlishock, John T.] Virginia Commonwealth Univ, Dept Anat & Neurobiol, Richmond, VA USA. [Kochanek, Patrick M.] Univ Pittsburgh, Sch Med, Safar Ctr Resuscitat Res, Dept Crit Care Med, 3434 Fifth Ave, Pittsburgh, PA 15260 USA. RP Kochanek, PM (reprint author), Univ Pittsburgh, Sch Med, Safar Ctr Resuscitat Res, Dept Crit Care Med, 3434 Fifth Ave, Pittsburgh, PA 15260 USA. EM kochanekpm@ccm.upmc.edu NR 50 TC 4 Z9 4 U1 1 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD MAR 15 PY 2016 VL 33 IS 6 BP 567 EP 580 DI 10.1089/neu.2015.4130 PG 14 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA DG6HN UT WOS:000372184800006 PM 26541177 ER PT J AU Browning, M Shear, DA Bramlett, HM Dixon, CE Mondello, S Schmid, KE Poloyac, SM Dietrich, WD Hayes, RL Wang, KKW Povlishock, JT Tortella, FC Kochanek, PM AF Browning, Megan Shear, Deborah A. Bramlett, Helen M. Dixon, C. Edward Mondello, Stefania Schmid, Kara E. Poloyac, Samuel M. Dietrich, W. Dalton Hayes, Ronald L. Wang, Kevin K. W. Povlishock, John T. Tortella, Frank C. Kochanek, Patrick M. TI Levetiracetam Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy SO JOURNAL OF NEUROTRAUMA LA English DT Article DE rat; post-traumatic seizures; penetrating ballistic-like brain injury; fluid percussion; excitotoxicity; controlled cortical impact; biomarker; Keppra; neuroprotection; therapy ID CONTROLLED CORTICAL IMPACT; SEIZURE PROPHYLAXIS; INTRAVENOUS LEVETIRACETAM; POSTTRAUMATIC EPILEPSY; STATUS EPILEPTICUS; MODEL; RAT; HYPOTHERMIA; DEFICITS; PROTEIN AB Levetiracetam (LEV) is an antiepileptic agent targeting novel pathways. Coupled with a favorable safety profile and increasing empirical clinical use, it was the fifth drug tested by Operation Brain Trauma Therapy (OBTT). We assessed the efficacy of a single 15 min post-injury intravenous (IV) dose (54 or 170 mg/kg) on behavioral, histopathological, and biomarker outcomes after parasagittal fluid percussion brain injury (FPI), controlled cortical impact (CCI), and penetrating ballistic-like brain injury (PBBI) in rats. In FPI, there was no benefit on motor function, but on Morris water maze (MWM), both doses improved latencies and path lengths versus vehicle (p < 0.05). On probe trial, the vehicle group was impaired versus sham, but both LEV treated groups did not differ versus sham, and the 54 mg/kg group was improved versus vehicle (p < 0.05). No histological benefit was seen. In CCI, there was a benefit on beam balance at 170 mg/kg (p < 0.05 vs. vehicle). On MWM, the 54 mg/kg dose was improved and not different from sham. Probe trial did not differ between groups for either dose. There was a reduction in hemispheric tissue loss (p < 0.05 vs. vehicle) with 170 mg/kg. In PBBI, there was no motor, cognitive, or histological benefit from either dose. Regarding biomarkers, in CCI, 24 h glial fibrillary acidic protein (GFAP) blood levels were lower in the 170 mg/kg group versus vehicle (p < 0.05). In PBBI, GFAP blood levels were increased in vehicle and 170 mg/kg groups versus sham (p < 0.05) but not in the 54 mg/kg group. No treatment effects were seen for ubiquitin C-terminal hydrolase-L1 across models. Early single IV LEV produced multiple benefits in CCI and FPI and reduced GFAP levels in PBBI. LEV achieved 10 points at each dose, is the most promising drug tested thus far by OBTT, and the only drug to improve cognitive outcome in any model. LEV has been advanced to testing in the micropig model in OBTT. C1 [Browning, Megan; Kochanek, Patrick M.] Univ Pittsburgh, Sch Med, Safar Ctr Resuscitat Res, Dept Crit Care Med, 3434 Fifth Ave, Pittsburgh, PA 15260 USA. [Shear, Deborah A.; Schmid, Kara E.; Tortella, Frank C.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect Neurorestorat, Silver Spring, MD USA. [Bramlett, Helen M.; Dietrich, W. Dalton] Univ Miami, Miller Sch Med, Dept Neurol Surg, Miami Project Cure Paralysis, Miami, FL 33136 USA. [Bramlett, Helen M.] Vet Affairs Med Ctr, Bruce W Carter Dept, Miami, FL 33125 USA. [Dixon, C. Edward] Univ Pittsburgh, Sch Med, Brain Trauma Res Ctr, Dept Neurol Surg, Pittsburgh, PA 15260 USA. [Mondello, Stefania] Univ Messina, Dept Neurosci, Messina, Italy. [Poloyac, Samuel M.] Univ Pittsburgh, Sch Pharm, Ctr Pharmaceut Sci, Pittsburgh, PA 15260 USA. [Hayes, Ronald L.] Banyan Biomarkers Inc, Ctr Neuroprote & Biomarkers Res, Ctr Innovat Res, Alachua, FL USA. [Wang, Kevin K. W.] Univ Florida, Dept Psychiat & Neurosci, Ctr Neuroprote & Biomarkers Res, Gainesville, FL USA. [Povlishock, John T.] Virginia Commonwealth Univ, Dept Anat & Neurobiol, Richmond, VA USA. RP Kochanek, PM (reprint author), Univ Pittsburgh, Sch Med, Safar Ctr Resuscitat Res, Dept Crit Care Med, 3434 Fifth Ave, Pittsburgh, PA 15260 USA. EM kochanekpm@ccm.upmc.edu NR 40 TC 9 Z9 9 U1 1 U2 4 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD MAR 15 PY 2016 VL 33 IS 6 BP 581 EP 594 DI 10.1089/neu.2015.4131 PG 14 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA DG6HN UT WOS:000372184800007 PM 26671550 ER PT J AU Mondello, S Shear, DA Bramlett, HM Dixon, CE Schmid, KE Dietrich, WD Wang, KKW Hayes, RL Glushakova, O Catania, M Richieri, SP Povlishock, JT Tortella, FC Kochanek, PM AF Mondello, Stefania Shear, Deborah A. Bramlett, Helen M. Dixon, C. Edward Schmid, Kara E. Dietrich, W. Dalton Wang, Kevin K. W. Hayes, Ronald L. Glushakova, Olena Catania, Michael Richieri, Steven P. Povlishock, John T. Tortella, Frank C. Kochanek, Patrick M. TI Insight into Pre-Clinical Models of Traumatic Brain Injury Using Circulating Brain Damage Biomarkers: Operation Brain Trauma Therapy SO JOURNAL OF NEUROTRAUMA LA English DT Article DE theranostic; fluid percussion injury; rat; ubiquitin carboxyl-terminal hydrolase-L1; penetrating ballistic-like brain injury; biomarkers; glial fibrillary acidic protein; Morris water maze; controlled cortical impact ID BARRIER PERMEABILITY; BLOOD; FLUID; RATS; HYPOTHERMIA; BREAKDOWN; SEVERITY; MARKERS AB Operation Brain Trauma Therapy (OBTT) is a multicenter pre-clinical drug screening consortium testing promising therapies for traumatic brain injury (TBI) in three well-established models of TBI in rats-namely, parasagittal fluid percussion injury (FPI), controlled cortical impact (CCI), and penetrating ballistic-like brain injury (PBBI). This article presents unique characterization of these models using histological and behavioral outcomes and novel candidate biomarkers from the first three treatment trials of OBTT. Adult rats underwent CCI, FPI, or PBBI and were treated with vehicle (VEH). Shams underwent all manipulations except trauma. The glial marker glial fibrillary acidic protein (GFAP) and the neuronal marker ubiquitin C-terminal hydrolase (UCH-L1) were measured by enzyme-linked immunosorbent assay in blood at 4 and 24 h, and their delta 24-4 h was calculated for each marker. Comparing sham groups across experiments, no differences were found in the same model. Similarly, comparing TBI + VEH groups across experiments, no differences were found in the same model. GFAP was acutely increased in injured rats in each model, with significant differences in levels and temporal patterns mirrored by significant differences in delta 24-4 h GFAP levels and neuropathological and behavioral outcomes. Circulating GFAP levels at 4 and 24 h were powerful predictors of 21 day contusion volume and tissue loss. UCH-L1 showed similar tendencies, albeit with less robust differences between sham and injury groups. Significant differences were also found comparing shams across the models. Our findings (1) demonstrate that TBI models display specific biomarker profiles, functional deficits, and pathological consequence; (2) support the concept that there are different cellular, molecular, and pathophysiological responses to TBI in each model; and (3) advance our understanding of TBI, providing opportunities for a successful translation and holding promise for theranostic applications. Based on our findings, additional studies in pre-clinical models should pursue assessment of GFAP as a surrogate histological and/or theranostic end-point. C1 [Mondello, Stefania] Univ Messina, Dept Neurosci, Messina, Italy. [Shear, Deborah A.; Schmid, Kara E.; Tortella, Frank C.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect Neurorestorat, Silver Spring, MD USA. [Bramlett, Helen M.; Dietrich, W. Dalton] Univ Miami, Miller Sch Med, Miami Project Cure Paralysis, Dept Neurol Surg, Miami, FL 33136 USA. [Bramlett, Helen M.] Vet Affairs Med Ctr, Bruce W Carter Dept, Miami, FL 33125 USA. [Dixon, C. Edward] Univ Pittsburgh, Sch Med, Brain Trauma Res Ctr, Dept Neurol Surg, Pittsburgh, PA 15260 USA. [Wang, Kevin K. W.] Univ Florida, Dept Psychiat & Neurosci, Ctr Neuroprote & Biomarkers Res, Gainesville, FL USA. [Hayes, Ronald L.] Banyan Biomarkers Inc, Ctr Neuroprote & Biomarkers Res, Ctr Innovat Res, Alachua, FL USA. [Glushakova, Olena; Catania, Michael; Richieri, Steven P.] Banyan Biomarkers, Alachua, FL USA. [Povlishock, John T.] Virginia Commonwealth Univ, Dept Anat & Neurobiol, Richmond, VA USA. [Kochanek, Patrick M.] Univ Pittsburgh, Sch Med, Dept Crit Care Med, Safar Ctr Resuscitat Res, 3434 Fifth Ave, Pittsburgh, PA 15260 USA. RP Kochanek, PM (reprint author), Univ Pittsburgh, Sch Med, Dept Crit Care Med, Safar Ctr Resuscitat Res, 3434 Fifth Ave, Pittsburgh, PA 15260 USA. EM kochanekpm@ccm.upmc.edu NR 31 TC 9 Z9 9 U1 2 U2 7 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD MAR 15 PY 2016 VL 33 IS 6 BP 595 EP 605 DI 10.1089/neu.2015.4132 PG 11 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA DG6HN UT WOS:000372184800008 PM 26671651 ER PT J AU Kochanek, PM Bramlett, HM Shear, DA Dixon, CE Mondello, S Dietrich, WD Hayes, RL Wang, KKW Poloyac, SM Empey, PE Povlishock, JT Mountney, A Browning, M Deng-Bryant, Y Yan, HQ Jackson, TC Catania, M Glushakova, O Richieri, SP Tortella, FC AF Kochanek, Patrick M. Bramlett, Helen M. Shear, Deborah A. Dixon, C. Edward Mondello, Stefania Dietrich, W. Dalton Hayes, Ronald L. Wang, Kevin K. W. Poloyac, Samuel M. Empey, Philip E. Povlishock, John T. Mountney, Andrea Browning, Megan Deng-Bryant, Ying Yan, Hong Q. Jackson, Travis C. Catania, Michael Glushakova, Olena Richieri, Steven P. Tortella, Frank C. TI Synthesis of Findings, Current Investigations, and Future Directions: Operation Brain Trauma Therapy SO JOURNAL OF NEUROTRAUMA LA English DT Article DE traumatic brain injury; therapy; rat; biomarker; controlled cortical impact; pre-clinical modeling; micropig; penetrating ballistic-like brain injury; reproducibility; fluid percussion; drug ID CONTROLLED CORTICAL IMPACT; MICROGLIAL ACTIVATION; HEMORRHAGIC-SHOCK; RAT MODEL; INJURY; AMANTADINE; DEFICITS; MICE; NEUROPROTECTION; PERFORMANCE AB Operation Brain Trauma Therapy (OBTT) is a fully operational, rigorous, and productive multicenter, pre-clinical drug and circulating biomarker screening consortium for the field of traumatic brain injury (TBI). In this article, we synthesize the findings from the first five therapies tested by OBTT and discuss both the current work that is ongoing and potential future directions. Based on the results generated from the first five therapies tested within the exacting approach used by OBTT, four (nicotinamide, erythropoietin, cyclosporine A, and simvastatin) performed below or well below what was expected based on the published literature. OBTT has identified, however, the early post-TBI administration of levetiracetam as a promising agent and has advanced it to a gyrencephalic large animal model-fluid percussion injury in micropigs. The sixth and seventh therapies have just completed testing (glibenclamide and Kollidon VA 64), and an eighth drug (AER 271) is in testing. Incorporation of circulating brain injury biomarker assessments into these pre-clinical studies suggests considerable potential for diagnostic and theranostic utility of glial fibrillary acidic protein in pre-clinical studies. Given the failures in clinical translation of therapies in TBI, rigorous multicenter, pre-clinical approaches to therapeutic screening such as OBTT may be important for the ultimate translation of therapies to the human condition. C1 [Kochanek, Patrick M.; Browning, Megan; Jackson, Travis C.] Univ Pittsburgh, Sch Med, Safar Ctr Resuscitat Res, Dept Crit Care Med, 3434 Fifth Ave, Pittsburgh, PA 15260 USA. [Bramlett, Helen M.; Dietrich, W. Dalton] Univ Miami, Miller Sch Med, Miami Project Cure Paralysis, Dept Neurol Surg, Miami, FL 33136 USA. [Bramlett, Helen M.] Vet Affairs Med Ctr, Bruce W Carter Dept, Miami, FL 33125 USA. [Shear, Deborah A.; Mountney, Andrea; Deng-Bryant, Ying; Tortella, Frank C.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect Neurorestorat, Silver Spring, MD USA. [Dixon, C. Edward; Yan, Hong Q.] Univ Pittsburgh, Sch Med, Brain Trauma Res Ctr, Dept Neurol Surg, Pittsburgh, PA 15260 USA. [Mondello, Stefania] Univ Messina, Dept Neurosci, Messina, Italy. [Hayes, Ronald L.] Banyan Biomarkers Inc, Ctr Neuroprote & Biomarkers Res, Ctr Innovat Res, Alachua, FL USA. [Wang, Kevin K. W.] Univ Florida, Dept Psychiat & Neurosci, Ctr Neuroprote & Biomarkers Res, Gainesville, FL USA. [Poloyac, Samuel M.; Empey, Philip E.] Univ Pittsburgh, Sch Pharm, Ctr Pharmaceut Sci, Pittsburgh, PA 15260 USA. [Povlishock, John T.] Virginia Commonwealth Univ, Dept Anat & Neurobiol, Richmond, VA USA. [Catania, Michael; Glushakova, Olena; Richieri, Steven P.] Banyan Biomarkers, Alachua, FL USA. RP Kochanek, PM (reprint author), Univ Pittsburgh, Sch Med, Safar Ctr Resuscitat Res, Dept Crit Care Med, 3434 Fifth Ave, Pittsburgh, PA 15260 USA. EM kochanekpm@ccm.upmc.edu NR 52 TC 4 Z9 4 U1 2 U2 3 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD MAR 15 PY 2016 VL 33 IS 6 BP 606 EP 614 DI 10.1089/neu.2015.4133 PG 9 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA DG6HN UT WOS:000372184800009 PM 26671284 ER PT J AU Morriss, BF Ochs, E Deeb, EJ Newman, SD Daly, SF Gagnon, JJ AF Morriss, B. F. Ochs, E. Deeb, E. J. Newman, S. D. Daly, S. F. Gagnon, J. J. TI Persistence-based temporal filtering for MODIS snow products SO REMOTE SENSING OF ENVIRONMENT LA English DT Article DE MODIS; Snow covered area; Cloud-free; Gap-fill ID COVER; ALBEDO AB Single-day snow covered area (SCA) products are incomplete and often inadequate representations of ground conditions due to short term variation in cloud cover, snow cover, and sensor geometry. To mitigate these effects, we developed a by-pixel filtering algorithm to produce relatively cloud-free SCA products from 16 days of MODIS imagery. The algorithm uses previous days' data to estimate the current SCA value of each pixel and uses a simple persistence test to reduce the effects of spurious SCA/cloud classifications in the input products. To be positively identified as SCA, a pixel must be snow-covered in the two most recent, cloud-free scenes of the 16-day period. We applied this time-domain-filtering (TDF) methodology to two single-day MODIS fractional snow cover products (MOD10A1 and MODSCAG) over the MODIS period of record (2000-present) and compared the outputs to the unfiltered products, to filtered maps generated using the cloud-gap-filled algorithm (CGF, Hall et al., 2010), and to historical snow assessment reports from the U.S. Army Corps of Engineers, Cold Regions Research and Engineering Laboratory (CRREL). The CRREL reports were manually generated and quality-controlled by an analyst and are treated as ground truth. We find that, when applied to MODSCAG, the TDF algorithm successfully fills in gap pixels and limits the effects of snow/cloud confusion and produces a filtered product that is more consistent and accurate than the MODSCAG CGF product and comparable to the MOD10A1 CGF product. (c) 2016 Elsevier Inc All rights reserved. C1 [Morriss, B. F.; Ochs, E.; Deeb, E. J.; Newman, S. D.; Daly, S. F.; Gagnon, J. J.] US Army Corps Engineers, Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH USA. RP Morriss, BF (reprint author), US Army Corps Engineers, Cold Reg Res & Engn Lab USACE CRREL, Hanover, NH USA. EM blaine.f.morriss@erdc.dren.mil FU U.S. Army Terrestrial Environmental Modeling and Intelligence System (ARTEMIS) applied science research program - Assistant Secretary of the Army for Acquisition, Logistics, and Technology (ASA-ALT); Cold Regions Research and Engineering Laboratory (CRREL) FX This work was supported by the U.S. Army Terrestrial Environmental Modeling and Intelligence System (ARTEMIS) applied science research program sponsored by the Assistant Secretary of the Army for Acquisition, Logistics, and Technology (ASA-ALT) and by the Cold Regions Research and Engineering Laboratory (CRREL). The MOD10A1 data product is courtesy of the National Snow and Ice Data Center (NSIDC) Distributed Active Archive Center (DAAC), NSIDC, Boulder, Colorado. The MOD09GA data product is courtesy of the online Data Pool at the NASA Land Processes (LP) DAAC, USGS/Earth Resources Observation and Science (EROS) Center, Sioux Falls, South Dakota. Both the MOD09GA and MOD10A1 can be accessed free-of-charge via NASA Earth Observing System Data and Information System (EOSDIS) Reverb (http://reverb.echo.nasa.gov/reverb/). MODSCAG data product is courtesy of the NASA Jet Propulsion Laboratory (JPL), Pasadena, California. NR 17 TC 2 Z9 2 U1 2 U2 10 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0034-4257 EI 1879-0704 J9 REMOTE SENS ENVIRON JI Remote Sens. Environ. PD MAR 15 PY 2016 VL 175 BP 130 EP 137 DI 10.1016/j.rse.2015.12.030 PG 8 WC Environmental Sciences; Remote Sensing; Imaging Science & Photographic Technology SC Environmental Sciences & Ecology; Remote Sensing; Imaging Science & Photographic Technology GA DF0AC UT WOS:000371000000011 ER PT J AU Moore, JD Barnes, BC Izvekov, S Lisal, M Sellers, MS Taylor, DE Brennan, JK AF Moore, Joshua D. Barnes, Brian C. Izvekov, Sergei Lisal, Martin Sellers, Michael S. Taylor, DeCarlos E. Brennan, John K. TI A coarse-grain force field for RDX: Density dependent and energy conserving SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID DISSIPATIVE PARTICLE DYNAMICS; CYCLOTRIMETHYLENE-TRINITRAMINE; BIOMOLECULAR SYSTEMS; MOLECULAR-DYNAMICS; ELASTIC-CONSTANTS; SIMULATIONS; CONSERVATION; POTENTIALS; PENTAERYTHRITOL; ALGORITHMS AB We describe the development of a density-dependent transferable coarse-grain model of crystalline hexahydro-1,3,5-trinitro-s-triazine (RDX) that can be used with the energy conserving dissipative particle dynamics method. The model is an extension of a recently reported one-site model of RDX that was developed by using a force-matching method. The density-dependent forces in that original model are provided through an interpolation scheme that poorly conserves energy. The development of the new model presented in this work first involved a multi-objective procedure to improve the structural and thermodynamic properties of the previous model, followed by the inclusion of the density dependency via a conservative form of the force field that conserves energy. The new model accurately predicts the density, structure, pressure-volume isotherm, bulk modulus, and elastic constants of the RDX crystal at ambient pressure and exhibits transferability to a liquid phase at melt conditions. (C) 2016 AIP Publishing LLC. C1 [Moore, Joshua D.; Barnes, Brian C.; Izvekov, Sergei; Sellers, Michael S.; Taylor, DeCarlos E.; Brennan, John K.] US Army, Energet Mat Sci Branch, RDRL WML B, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Lisal, Martin] Acad Sci Czech Republic, Inst Chem Proc Fundamentals, Vvi, Lab Aerosols Chem & Phys, CR-16502 Prague 6, Suchdol, Czech Republic. [Lisal, Martin] Univ JE Purkyne, Inst Sci, Dept Phys, Usti Nad Labem 40096, Czech Republic. RP Moore, JD (reprint author), US Army, Energet Mat Sci Branch, RDRL WML B, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RI Lisal, Martin/A-8176-2011 OI Lisal, Martin/0000-0001-8005-7143 FU Office of Naval Research; Department of Defense High Performance Computing Modernization Program Software Application Institute for Multiscale Reactive Modeling of Insensitive Munitions; ARL [W911NF-10-2-0039]; Czech Science Foundation [13-02938S] FX The authors would like to thank James Larentzos (Engility Corp.), Jean-Bernard Maillet (Commissariat a l'energie atomique et aux energies alternatives, DAM), Thomas D. Sewell (University of Missouri), and ARL scientists William Mattson, Timothy Sirk, and Todd Beaudet for insightful discussions. The authors acknowledge the computational resources and PETTT software support from the High Performance Computing Modernization office. J.D.M. and B.C.B. acknowledge support in part by an appointment to the U.S. Army Research Laboratory Postdoctoral Fellowship Program administered by the Oak Ridge Associated Universities through a cooperative agreement with the U.S. Army Research Laboratory. J.K.B. and J.D.M. acknowledge support in part by the Office of Naval Research and the Department of Defense High Performance Computing Modernization Program Software Application Institute for Multiscale Reactive Modeling of Insensitive Munitions. M.L. acknowledges sponsorship by the ARL under Cooperative Agreement No. W911NF-10-2-0039, and the Czech Science Foundation under Project No. 13-02938S. NR 66 TC 4 Z9 4 U1 7 U2 22 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-9606 EI 1089-7690 J9 J CHEM PHYS JI J. Chem. Phys. PD MAR 14 PY 2016 VL 144 IS 10 AR 104501 DI 10.1063/1.4942520 PG 11 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA DH7LE UT WOS:000372974600019 PM 26979691 ER PT J AU Gardea, F Glaz, B Riddick, J Lagoudas, DC Naraghi, M AF Gardea, Frank Glaz, Bryan Riddick, Jaret Lagoudas, Dimitris C. Naraghi, Mohammad TI Identification of energy dissipation mechanisms in CNT-reinforced nanocomposites SO NANOTECHNOLOGY LA English DT Article DE damping; nanocomposites; matrix plasticity; interfacial slip; agglomeration ID NANOTUBE-BASED COMPOSITES; SHEAR-LAG MODEL; POLYMER COMPOSITES; CARBON NANOTUBES; ENHANCEMENT; MATRIX AB In this paper we present our recent findings on the mechanisms of energy dissipation in polymerbased nanocomposites obtained through experimental investigations. The matrix of the nanocomposite was polystyrene (PS) which was reinforced with carbon nanotubes (CNTs). To study the mechanical strain energy dissipation of nanocomposites, we measured the ratio of loss to storage modulus for different CNT concentrations and alignments. CNT alignment was achieved via hot-drawing of PS-CNT. In addition, CNT agglomeration was studied via a combination of SEM imaging and Raman scanning. We found that at sufficiently low strains, energy dissipation in composites with high CNT alignment is not a function of applied strain, as no interfacial slip occurs between the CNTs and PS. However, below the interfacial slip strain threshold, damping scales monotonically with CNT content, which indicates the prevalence of CNT-CNT friction dissipation mechanisms within agglomerates. At higher strains, interfacial slip also contributes to energy dissipation. However, the increase in damping with strain, especially when CNT agglomerates are present, does not scale linearly with the effective interface area between CNTs and PS, suggesting a significant contribution of friction between CNTs within agglomerates to energy dissipation at large strains. In addition, for the first time, a comparison between the energy dissipation in randomly oriented and aligned CNT composites was made. It is inferred that matrix plasticity and tearing caused by misorientation of CNTs with the loading direction is a major cause of energy dissipation. The results of our research can be used to design composites with high energy dissipation capability, especially for applications where dynamic loading may compromise structural stability and functionality, such as rotary wing structures and antennas. C1 [Gardea, Frank; Lagoudas, Dimitris C.; Naraghi, Mohammad] Texas A&M Univ, Dept Aerosp Engn, College Stn, TX 77843 USA. [Glaz, Bryan; Riddick, Jaret] US Army Res Lab, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Naraghi, M (reprint author), Texas A&M Univ, Dept Aerosp Engn, College Stn, TX 77843 USA. EM Naraghi@tamu.edu FU DOD-Army Research Laboratory [W911NF-14-2-0080] FX The use of the Texas A & M University Materials Characterization Facility is acknowledged. M N and D C L would like to acknowledge the support of DOD-Army Research Laboratory, under the award No. W911NF-14-2-0080. NR 30 TC 2 Z9 2 U1 9 U2 33 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0957-4484 EI 1361-6528 J9 NANOTECHNOLOGY JI Nanotechnology PD MAR 11 PY 2016 VL 27 IS 10 AR 105707 DI 10.1088/0957-4484/27/10/105707 PG 9 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Science & Technology - Other Topics; Materials Science; Physics GA DD3US UT WOS:000369849200019 PM 26866611 ER PT J AU Reish, ME Zhang, Z Ma, SL Harrison, I Everitt, HO AF Reish, Matthew E. Zhang, Zhen Ma, Shiliang Harrison, Ian Everitt, Henry O. TI How Annealing and Charge Scavengers Affect Visible Emission from ZnO Nanocrystals SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID MICROCRYSTALLINE ZINC-OXIDE; OPTICAL-PROPERTIES; GREEN PHOTOLUMINESCENCE; ELECTRONIC-STRUCTURE; COPPER IMPURITIES; PHOSPHOR POWDERS; CONDUCTION-BAND; SPRAY-PYROLYSIS; UNDOPED ZNO; DEFECTS AB Simultaneous transmission infrared (IR) absorption and photoluminescence (PL) spectroscopies are used to reveal the correlation of free electron and defect densities during the stepwise annealing of ZnO nanocrystals in high vacuum. For increasing annealing temperatures between 700 and 1000 K, the free electron density increases with a negligible increase in PL yield. With increased annealing temperature above 1000 K, the free electron density decreases and the PL yield increases in inverse proportion. Accompanying the free electron loss are indications of increased bound charges and changes in the multiphonon bands in the infrared spectrum, which collectively suggest that structural change and defect formation accompanies the loss of free electrons and the increase in PL. Exposure of the previously annealed sample to electron (02) and hole (MeOH) scavengers shows that the buildup of holes quenches visible emission, while additional electrons have a marginal effect on the PL yield. Given that certain neutral donors bind excitons and facilitate energy transfer to visible emitting sites, the buildup of free holes appears to quench PL intensity by ionizing those neutral donors. C1 [Reish, Matthew E.; Zhang, Zhen; Ma, Shiliang; Harrison, Ian] Univ Virginia, Dept Chem, Charlottesville, VA 22904 USA. [Everitt, Henry O.] US Army, Aviat & Missile RD&E Ctr, Redstone Arsenal, AL 35898 USA. [Everitt, Henry O.] Duke Univ, Dept Phys, Durham, NC 27708 USA. RP Everitt, HO (reprint author), US Army, Aviat & Missile RD&E Ctr, Redstone Arsenal, AL 35898 USA. EM everitt@phy.duke.edu RI Zhang, Zhen/C-6006-2008 OI Zhang, Zhen/0000-0001-6736-1677 FU Army Research Office [55748CH]; AES Corporation FX The authors acknowledge the critical role John T. Yates played encouraging and supporting the pursuit this project. The authors also acknowledge helpful discussions with J. G. Simmons and J. V. Foreman. We acknowledge with thanks the support of this work by the Army Research Office under Grant 55748CH and the AES Corporation for a fellowship for Shiliang Ma through the AES Graduate Fellowship in the Energy Research Program at the University of Virginia. NR 52 TC 0 Z9 0 U1 3 U2 10 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD MAR 10 PY 2016 VL 120 IS 9 BP 5108 EP 5113 DI 10.1021/acs.jpcc.5b12094 PG 6 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA DG4LB UT WOS:000372042600042 ER PT J AU Yu, SQ Cai, YY Lyons, C Johnson, RF Postnikova, E Mazur, S Johnson, JC Radoshitzky, SR Bailey, AL Lauck, M Goldberg, TL O'Connor, DH Jahrling, PB Friedrich, TC Kuhn, JH AF Yu, Shuiqing Cai, Yingyun Lyons, Cassandra Johnson, Reed F. Postnikova, Elena Mazur, Steven Johnson, Joshua C. Radoshitzky, Sheli R. Bailey, Adam L. Lauck, Michael Goldberg, Tony L. O'Connor, David H. Jahrling, Peter B. Friedrich, Thomas C. Kuhn, Jens H. TI Specific Detection of Two Divergent Simian Arteriviruses Using RNAscope In Situ Hybridization SO PLOS ONE LA English DT Article ID RESPIRATORY-SYNDROME-VIRUS; HEMORRHAGIC-FEVER; MACAQUES; DISEASE; TISSUES; RNA; CIRCOVIRUS; INFECTION AB Simian hemorrhagic fever (SHF) is an often lethal disease of Asian macaques. Simian hemorrhagic fever virus (SHFV) is one of at least three distinct simian arteriviruses that can cause SHF, but pathogenesis studies using modern methods have been scarce. Even seemingly straightforward studies, such as examining viral tissue and cell tropism in vivo, have been difficult to conduct due to the absence of standardized SHFV-specific reagents. Here we report the establishment of an in situ hybridization assay for the detection of SHFV and distantly related Kibale red colobus virus 1 (KRCV-1) RNA in cell culture. In addition, we detected SHFV RNA in formalin-fixed, paraffin-embedded tissues from an infected rhesus monkey (Macaca mulatta). The assay is easily performed and can clearly distinguish between SHFV and KRCV-1. Thus, if further developed, this assay may be useful during future studies evaluating the mechanisms by which a simian arterivirus with a restricted cell tropism can cause a lethal nonhuman primate disease similar in clinical presentation to human viral hemorrhagic fevers. C1 [Yu, Shuiqing; Cai, Yingyun; Lyons, Cassandra; Postnikova, Elena; Mazur, Steven; Johnson, Joshua C.; Jahrling, Peter B.; Kuhn, Jens H.] NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD USA. [Johnson, Reed F.; Jahrling, Peter B.] NIAID, Emerging Infect Pathogens Sect, NIH, Frederick, MD USA. [Radoshitzky, Sheli R.] US Army Med Res Inst Infect Dis, Frederick, MD USA. [Bailey, Adam L.; Lauck, Michael; Goldberg, Tony L.; O'Connor, David H.; Friedrich, Thomas C.] Univ Wisconsin, Madison, WI USA. RP Kuhn, JH (reprint author), NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD USA. EM kuhnjens@mail.nih.gov OI Friedrich, Thomas/0000-0001-9831-6895 FU Battelle Memorial Institute's prime contract the US National Institute of Allergy and Infectious Diseases (NIAID) [HHSN272200700016I]; Battelle Memorial Institute; Tunnell Government Services; MRIGlobal; NIAID Division of Intramural Research; National Institutes of Health (NIH) [TW009237, R01 AI077376]; Office of Research Infrastructure Programs (ORIP) [P51OD011106] FX The content of this publication does not necessarily reflect the views or policies of the US Department of Defense, the US Department of Health and Human Services, the US Department of the Army, or the institutions and companies affiliated with the authors. This work was funded in part through Battelle Memorial Institute's prime contract the US National Institute of Allergy and Infectious Diseases (NIAID) under Contract No. HHSN272200700016I (S.Y., Y.C., C.L., E.P., S.M., J.C.J., P.B.J., J.H.K.). S.Y. and J.C.J. performed this work as employees of Battelle Memorial Institute. Subcontractors to Battelle Memorial Institute who performed this work are: Y.C., C.L., E.P., and J.H.K, employees of Tunnell Government Services, Inc.; and S.M., an employee of MRIGlobal. Battelle Memorial Institute, Tunnell Government Services, and MRIGlobal provided support in the form of salaries, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. All work under contract HHSN272200700016I is performed under the agreement/understanding that it will belong to the client and will be affiliated directly to the NIH/NIAID Integrated Research Facility at Fort Detrick. The specific roles of these authors are articulated in the 'author contributions' section. This work was also supported, in part, by the NIAID Division of Intramural Research (R.F.J., P.B.J.), by National Institutes of Health (NIH) grant TW009237 as part of the joint NIH-NSF Ecology of Infectious Disease program, grant R01 AI077376, and by the Office of Research Infrastructure Programs (ORIP) grant P51OD011106 (A.L.B., M.L., T.L.G., D.H.O'C., T.C.F.). These funders did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 28 TC 0 Z9 0 U1 0 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAR 10 PY 2016 VL 11 IS 3 AR e0151313 DI 10.1371/journal.pone.0151313 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DG3TL UT WOS:000371993000136 PM 26963736 ER PT J AU Ayangeakaa, AD Janssens, RVF Wu, CY Allmond, JM Wood, JL Zhu, S Albers, M Almaraz-Calderon, S Bucher, B Carpenter, MP Chiara, CJ Cline, D Crawford, HL David, HM Harker, J Hayes, AB Hoffman, CR Kay, BP Kolos, K Korichi, A Lauritsen, T Macchiavelli, AO Richard, A Seweryniak, D Wiens, A AF Ayangeakaa, A. D. Janssens, R. V. F. Wu, C. Y. Allmond, J. M. Wood, J. L. Zhu, S. Albers, M. Almaraz-Calderon, S. Bucher, B. Carpenter, M. P. Chiara, C. J. Cline, D. Crawford, H. L. David, H. M. Harker, J. Hayes, A. B. Hoffman, C. R. Kay, B. P. Kolos, K. Korichi, A. Lauritsen, T. Macchiavelli, A. O. Richard, A. Seweryniak, D. Wiens, A. TI Shape coexistence and the role of axial asymmetry in Ge-72 SO PHYSICS LETTERS B LA English DT Article ID INTERACTING BOSON MODEL; COULOMB-EXCITATION; EXCITED-STATES; ALPHA-DECAY; ATOMIC-NUCLEI; O+ STATES; ISOTOPES; NI-68; TRANSITION; REGION AB The quadrupole collectivity of low-lying states and the anomalous behavior of the 0(2)(+) and 2(3)(+) levels in Ge-72 are investigated via projectile multi-step Coulomb excitation with GRETINA and CHICO-2. Atotal of forty six E2 and M1 matrix elements connecting fourteen low-lying levels were determined using the least-squares search code, GOSIA. Evidence for triaxiality and shape coexistence, based on the model-independent shape invariants deduced from the Kumar-Cline sum rule, is presented. These are interpreted using a simple two-state mixing model as well as multi-state mixing calculations carried out within the framework of the triaxial rotor model. The results represent a significant milestone towards the understanding of the unusual structure of this nucleus. (C) 2016 The Authors. Published by Elsevier B.V. C1 [Ayangeakaa, A. D.; Janssens, R. V. F.; Zhu, S.; Albers, M.; Almaraz-Calderon, S.; Carpenter, M. P.; Chiara, C. J.; David, H. M.; Harker, J.; Hoffman, C. R.; Kay, B. P.; Lauritsen, T.; Seweryniak, D.] Argonne Natl Lab, Div Phys, Argonne, IL 60439 USA. [Wu, C. Y.; Bucher, B.] Lawrence Livermore Natl Lab, Livermore, CA 94550 USA. [Allmond, J. M.] Oak Ridge Natl Lab, Div Phys, Oak Ridge, TN 37831 USA. [Wood, J. L.] Georgia Inst Technol, Sch Phys, Atlanta, GA 30332 USA. [Allmond, J. M.] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA. [Cline, D.; Hayes, A. B.] Univ Rochester, Dept Phys & Astron, Rochester, NY 14627 USA. [Crawford, H. L.; Richard, A.] Ohio Univ, Dept Phys & Astron, Inst Nucl & Particle Phys, Athens, OH 45701 USA. [Kolos, K.] Univ Tennessee, Dept Phys & Astron, Knoxville, TN 37996 USA. [Korichi, A.] CNRS, CSNSM, IN2P3, F-91405 Orsay, France. [Korichi, A.] Univ Paris 11, F-91405 Orsay, France. [Crawford, H. L.; Macchiavelli, A. O.; Wiens, A.] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Nucl Sci, 1 Cyclotron Rd, Berkeley, CA 94720 USA. [Albers, M.] Ernst & Young GmbH, Mergenthalerallee 3-5, D-65760 Eschborn, Germany. [Almaraz-Calderon, S.] Florida State Univ, Dept Phys, Tallahassee, FL 32306 USA. [Chiara, C. J.] US Army Res Lab, Adelphi, MD 20783 USA. [David, H. M.] Helmholtzzentrum Schwerionenforsch GmbH, GSI, D-64291 Darmstadt, Germany. RP Ayangeakaa, AD (reprint author), Argonne Natl Lab, Div Phys, Argonne, IL 60439 USA. EM ayangeakaa@anl.gov RI Kay, Benjamin/F-3291-2011; OI Kay, Benjamin/0000-0002-7438-0208; Ayangeakaa, Akaa D./0000-0003-1679-3175 FU U.S. Department of Energy, Office of Science, Office of Nuclear Physics [DE-AC02-06CH11357, DE-AC52-07NA27344, DE-FG02-94ER40834, DE-FG0208ER41556]; National Science Foundation [0969079] FX This material is based upon work supported by the U.S. Department of Energy, Office of Science, Office of Nuclear Physics under Contract numbers DE-AC02-06CH11357 and DE-AC52-07NA27344, and under Grant Numbers DE-FG02-94ER40834 and DE-FG0208ER41556, and by the National Science Foundation under grant number 0969079. This research used resources of ANL's ATLAS facility, which is a DOE Office of Science User Facility. NR 54 TC 4 Z9 4 U1 5 U2 8 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0370-2693 EI 1873-2445 J9 PHYS LETT B JI Phys. Lett. B PD MAR 10 PY 2016 VL 754 BP 254 EP 259 DI 10.1016/j.physletb.2016.01.036 PG 6 WC Astronomy & Astrophysics; Physics, Nuclear; Physics, Particles & Fields SC Astronomy & Astrophysics; Physics GA DD0HM UT WOS:000369601000037 ER PT J AU Suchalkin, S Ludwig, J Belenky, G Laikhtman, B Kipshidze, G Lin, Y Shterengas, L Smirnov, D Luryi, S Sarney, WL Svensson, SP AF Suchalkin, S. Ludwig, J. Belenky, G. Laikhtman, B. Kipshidze, G. Lin, Y. Shterengas, L. Smirnov, D. Luryi, S. Sarney, W. L. Svensson, S. P. TI Electronic properties of unstrained unrelaxed narrow gap InAsx-Sb1-x alloys SO JOURNAL OF PHYSICS D-APPLIED PHYSICS LA English DT Article DE narrow gap semiconductors; metamorphic materials; II-V semiconductors ID BAND EFFECTIVE-MASS; INTERBAND MAGNETOABSORPTION; INFRARED DETECTORS; INAS; INSB; ANTIMONIDE; INASXSB1-X; DISORDER; LAYERS; GASB AB The electronic properties of unstrained unrelaxed InAsxSb1-x alloys have been determined in a wide range of alloy compositions using IR magnetospectroscopy, magnetotransport and IR photoluminescence, All studied alloys have n-type background doping with electron concentration decreasing with the Sb content, The composition dependence of the background doping concentration follows an empirical exponential law in a wide range of compositions. Both bandgap and electron effective mass dependence on alloy composition exhibit negative bowing reaching lowest values at X = 0,63: E-g = 0.10 eV, = 0,0082 m(0) at 4,2 K. The bowing coefficient of 0,038 m(0) obtained for the electron effective mass is in good agreement with that obtained from the Kane model. C1 [Suchalkin, S.; Belenky, G.; Kipshidze, G.; Lin, Y.; Shterengas, L.; Luryi, S.] SUNY Stony Brook, Stony Brook, NY 11794 USA. [Ludwig, J.; Smirnov, D.] Natl High Magnet Field Lab, Tallahassee, FL 32310 USA. [Ludwig, J.] Florida State Univ, Tallahassee, FL 32306 USA. [Laikhtman, B.] Hebrew Univ Jerusalem, Racah Inst Phys, IL-91904 Jerusalem, Israel. [Sarney, W. L.; Svensson, S. P.] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RP Suchalkin, S (reprint author), SUNY Stony Brook, Stony Brook, NY 11794 USA. EM sergey.suchalkin@stonybrook.edu FU US Army Research Office [W911NF1220057]; US National Science Foundation [DMR1160843]; US Department of Energy, Office of Basic Energy Sciences [DE-FG02-07ER46451]; National Science Foundation [DMR-1157490]; State of Florida FX The work was supported by US Army Research Office through award W911NF1220057 and by the US National Science Foundation through grant number DMR1160843. J L and D S acknowledge the support by the US Department of Energy, Office of Basic Energy Sciences (Grant number DE-FG02-07ER46451 for IR magnetospectroscopy and magnetotransport experiments and data analysis. The CR and magnetotransport measurements were performed at the National High Magnetic Field Laboratory, which is supported by National Science Foundation Cooperative Agreement number DMR-1157490 and the State of Florida. NR 26 TC 2 Z9 2 U1 7 U2 19 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0022-3727 EI 1361-6463 J9 J PHYS D APPL PHYS JI J. Phys. D-Appl. Phys. PD MAR 9 PY 2016 VL 49 IS 10 DI 10.1088/0022-3727/49/10/105101 PG 6 WC Physics, Applied SC Physics GA DE7NM UT WOS:000370824000005 ER PT J AU Gu, WT Borodin, O Zdyrko, B Lin, HT Kim, H Nitta, N Huang, JX Magasinski, A Milicev, Z Berdichevsky, G Yushin, G AF Gu, Wentian Borodin, Oleg Zdyrko, Bogdan Lin, Huan-Ting Kim, Hyea Nitta, Naoki Huang, Jiaxin Magasinski, Alexandre Milicev, Zoran Berdichevsky, Gene Yushin, Gleb TI Lithium-Iron Fluoride Battery with In Situ Surface Protection SO ADVANCED FUNCTIONAL MATERIALS LA English DT Article ID LI-ION BATTERIES; ORGANIC CARBONATE ELECTROLYTES; CONVERSION REACTION; RECHARGEABLE BATTERIES; GRAPHITE-ELECTRODES; SULFUR BATTERIES; METAL FLUORIDES; HF FORMATION; THIN-FILM; PERFORMANCE AB Lithium-metal fluoride (MF) batteries offer the highest theoretical energy density, exceeding that of the sulfur-lithium cells. However, conversion-type MF cathodes suffer from high resistance, small capacity utilization at room temperature, irreversible structural changes, and rapid capacity fading with cycling. In this study, the successful application of the approach to overcome such limitations and dramatically enhance electrochemical performance of Li-MF cells is reported. By using iron fluoride (FeF2) as an example, Li-MF cells capable of achieving near-theoretical capacity utilization are shown when MF is infiltrated into the carbon mesopores. Most importantly, the ability of electrolytes based on the lithium bis(fluorosulfonyl)imide (LiFSI) salt is presented to successfully prevent the cathode dissolution and leaching via in situ formation of a Li ion permeable protective surface layer. This layer forms as a result of electrolyte reduction/oxidation reactions during the first cycle of the conversion reaction, thus minimizing the capacity losses during cycling. Postmortem analysis shows the absence of Li dendrites, which is important for safer use of Li metal anodes. As a result, Li-FeF2 cells demonstrate over 1000 stable cycles. Quantum chemistry calculations and post-mortem analysis provide insights into the mechanisms of the passivation layer formation and the performance boost. C1 [Gu, Wentian; Lin, Huan-Ting; Nitta, Naoki; Huang, Jiaxin; Magasinski, Alexandre; Yushin, Gleb] Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA. [Borodin, Oleg] Army Res Lab, Sensor & Elect Devices Directorate, Electrochem Branch, Adelphi, MD 20783 USA. [Zdyrko, Bogdan; Kim, Hyea; Milicev, Zoran; Berdichevsky, Gene] Sila Nanotechnol Inc, Alameda, CA 94501 USA. RP Yushin, G (reprint author), Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA. EM yushin@gatech.edu FU AFOSR [FA95500-13-1-0054]; DOE [DE-EE0006862] FX Different aspects of this work were supported by AFOSR (grant FA95500-13-1-0054) and DOE (grant DE-EE0006862). Modeling was supported by ARL Enterprise on Multiscale Research. NR 53 TC 3 Z9 3 U1 47 U2 134 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 1616-301X EI 1616-3028 J9 ADV FUNCT MATER JI Adv. Funct. Mater. PD MAR 8 PY 2016 VL 26 IS 10 BP 1507 EP 1516 DI 10.1002/adfm.201504848 PG 10 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA DG8CC UT WOS:000372309000002 ER PT J AU Gong, P Nan, XF Barker, ND Boyd, RE Chen, YX Wilkins, DE Johnson, DR Suedel, BC Perkins, EJ AF Gong, Ping Nan, Xiaofei Barker, Natalie D. Boyd, Robert E. Chen, Yixin Wilkins, Dawn E. Johnson, David R. Suedel, Burton C. Perkins, Edward J. TI Predicting chemical bioavailability using microarray gene expression data and regression modeling: A tale of three explosive compounds SO BMC GENOMICS LA English DT Article DE Tissue residue; Global gene expression profiling; Predictor genes; Predictive regression modeling; TNT (2,4,6-Trinitrotoluene); RDX (1,3,5-Trinitro-1,3,5-triazacyclohexane); HMX (Octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine); Earthworm (Eisenia fetida) ID QUANTITATIVE PREDICTION; CANCER; CLASSIFICATION; ASSOCIATION; ANNOTATION; SELECTION; MARKERS; TRAITS AB Background: Chemical bioavailability is an important dose metric in environmental risk assessment. Although many approaches have been used to evaluate bioavailability, not a single approach is free from limitations. Previously, we developed a new genomics-based approach that integrated microarray technology and regression modeling for predicting bioavailability (tissue residue) of explosives compounds in exposed earthworms. In the present study, we further compared 18 different regression models and performed variable selection simultaneously with parameter estimation. Results: This refined approach was applied to both previously collected and newly acquired earthworm microarray gene expression datasets for three explosive compounds. Our results demonstrate that a prediction accuracy of R-2 = 0.71-0.82 was achievable at a relatively low model complexity with as few as 3-10 predictor genes per model. These results are much more encouraging than our previous ones. Conclusion: This study has demonstrated that our approach is promising for bioavailability measurement, which warrants further studies of mixed contamination scenarios in field settings C1 [Gong, Ping; Boyd, Robert E.; Suedel, Burton C.; Perkins, Edward J.] US Army, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Nan, Xiaofei; Chen, Yixin; Wilkins, Dawn E.] Univ Mississippi, Dept Comp & Informat Sci, Oxford, MS 38677 USA. [Barker, Natalie D.] Bennett Aerosp Inc, Cary, NC 27518 USA. [Johnson, David R.] GHD, Dallas, TX 75234 USA. [Nan, Xiaofei] Zhengzhou Univ, Sch Informat Engn, Zhengzhou 450001, Henan, Peoples R China. RP Gong, P (reprint author), US Army, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM ping.gong@usace.army.mil FU U.S. Army Environmental Quality/Installation Technology Research Program as part of project "Toxicogenomics for Assessment of Munitions and Explosives Related Compounds"; U.S. National Science Foundation [EPS 0903787]; U.S. Army Environmental Quality/Installation Technology Research Program as part of project "Impact of Munitions Constituents on Biological Networks" FX This work was funded by the U.S. Army Environmental Quality/Installation Technology Research Program as part of projects "Toxicogenomics for Assessment of Munitions and Explosives Related Compounds" and "Impact of Munitions Constituents on Biological Networks". Drs. X. Nan, Y. Chen and D. Wilkins were supported in part by the U.S. National Science Foundation under award number EPS 0903787. We thank Dr. Guilherme R. Lotufo of U.S. Army Corps of Engineers for his suggestion of using ScintiGest solubilizer for tissue digestion, and A. E. Elaine van Ommen Kloeke of VU University Amsterdam for sharing Blast2Go annotations of earthworm transcriptome. Permission to publish this information was granted by the Chief of Engineers. NR 27 TC 0 Z9 0 U1 7 U2 10 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2164 J9 BMC GENOMICS JI BMC Genomics PD MAR 8 PY 2016 VL 17 AR 205 DI 10.1186/s12864-016-2541-5 PG 10 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA DF8GO UT WOS:000371595700010 PM 26956490 ER PT J AU Crowell, TA Ganesan, A Berry, SA Deiss, RG Agan, BK Okulicz, JF AF Crowell, Trevor A. Ganesan, Anuradha Berry, Stephen A. Deiss, Robert G. Agan, Brian K. Okulicz, Jason F. CA Infect Dis Clinical Res Program ID TI Hospitalizations among HIV controllers and persons with medically controlled HIV in the US Military HIV Natural History Study SO JOURNAL OF THE INTERNATIONAL AIDS SOCIETY LA English DT Article DE HIV; HIV non-progressors; patient admission; hospitalization; highly active antiretroviral therapy ID T-CELL-ACTIVATION; LOW-LEVEL VIREMIA; ANTIRETROVIRAL THERAPY; ELITE CONTROLLERS; HEPATITIS COINFECTION; IMMUNE ACTIVATION; VIRAL REPLICATION; UNITED-STATES; HEALTH-CARE; INFECTION AB Introduction: HIV controllers (HICs) experience relatively low-level viraemia and CD4 preservation without antiretroviral therapy (ART), but also immune activation that may predispose to adverse clinical events such as cardiovascular disease and hospitalization. The objective of this study was to characterize the rates and reasons for hospitalization among HICs and persons with medically controlled HIV. Methods: Subjects with consistently well-controlled HIV were identified in the U.S. Military HIV Natural History Study. ART prescription and HIV-1 RNA data were used to categorize subjects as HICs or medically controlled as defined by >= 3 HIV-1 RNA measurements <= 2000 or <= 400 copies/mL, respectively, representing the majority of measurements spanning >= 12 months. Hospitalizations were tallied and assigned diagnostic categories. All-cause hospitalization rates were compared between groups using negative binomial regression. Results and discussion: Of 3106 subjects followed from 2000 to 2013, 221 were HICs, including 33 elite (1.1%) and 188 viraemic (6.0%) controllers, who contributed 882 person-years (PY) of observation time. An additional 870 subjects with medically controlled HIV contributed 4217 PY. Mean hospitalization rates were 9.4/100 PY among HICs and 8.8/100 PY among medically controlled subjects. Non-AIDS-defining infections were the most common reason for hospitalization (2.95/100 PY and 2.70/100 PY, respectively) and rates of cardiovascular hospitalization were similar in both groups (0.45/100 PY and 0.76/100 PY). There was no difference in hospitalization rate for HICs compared with subjects with medically controlled HIV (adjusted incidence rate ratio 1.15 [95% confidence interval 0.80 to 1.65]). Conclusions: All-cause and cardiovascular hospitalization rates did not differ between HICs and persons with medically controlled HIV. Non-AIDS defining infections were common in this young, healthy, predominantly male cohort of military personnel and beneficiaries. C1 [Okulicz, Jason F.] San Antonio Mil Med Ctr, Infect Dis Serv, 3551 Roger Brooke Dr, San Antonio, TX 78234 USA. [Crowell, Trevor A.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Crowell, Trevor A.; Ganesan, Anuradha; Deiss, Robert G.; Agan, Brian K.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Ganesan, Anuradha] Walter Reed Natl Mil Med Ctr, Infect Dis Serv, Bethesda, MD USA. [Ganesan, Anuradha; Deiss, Robert G.; Agan, Brian K.; Okulicz, Jason F.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biostat, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Berry, Stephen A.] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA. [Deiss, Robert G.] Naval Med Ctr San Diego, Infect Dis Clin, San Diego, CA USA. RP Crowell, TA (reprint author), US Mil HIV Res Program, 6720 A Rockledge Dr,Suite 400, Bethesda, MD 20817 USA.; Okulicz, JF (reprint author), San Antonio Mil Med Ctr, Infect Dis Serv, 3551 Roger Brooke Dr, San Antonio, TX 78234 USA. EM tcrowell@hivresearch.org; jason.f.okulicz.mil@mail.mil OI Agan, Brian/0000-0002-5114-1669 FU Infectious Disease Clinical Research Program (IDCRP) [IDCRP-000-05]; Department of Defense (DoD) program executed through the Uniformed Services University of the Health Sciences; National Institute of Allergy and Infectious Diseases (NIAID)/National Institutes of Health (NIH) [Y1-AI-5072]; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.; DoD [W81XWH-07-2-0067]; NIAID/NIH [K23AI084854] FX Support for this work (IDCRP-000-05) was provided by the Infectious Disease Clinical Research Program (IDCRP), a Department of Defense (DoD) program executed through the Uniformed Services University of the Health Sciences. This project has been funded in whole, or in part, with federal funds from the National Institute of Allergy and Infectious Diseases (NIAID)/National Institutes of Health (NIH), under Inter-Agency Agreement Y1-AI-5072; a cooperative agreement between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the DoD (W81XWH-07-2-0067); a grant to S.A.B. from NIAID/NIH (K23AI084854). NR 34 TC 1 Z9 1 U1 1 U2 4 PU INT AIDS SOCIETY PI GENEVA PA AVENUE DE FRANCE 23, GENEVA, 1202, SWITZERLAND SN 1758-2652 J9 J INT AIDS SOC JI J. Int. AIDS Soc. PD MAR 7 PY 2016 VL 19 AR 20524 DI 10.7448/IAS.19.1.20524 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA DM2JG UT WOS:000376172300001 PM 26955965 ER PT J AU Chau, N Slipher, GA O'Brien, BM Mrozek, RA Anderson, IA AF Chau, Nixon Slipher, Geoffrey A. O'Brien, Benjamin M. Mrozek, Randy A. Anderson, Iain A. TI A solid-state dielectric elastomer switch for soft logic SO APPLIED PHYSICS LETTERS LA English DT Article ID ACTUATORS; PERCOLATION AB In this paper, we describe a stretchable solid-state electronic switching material that operates at high voltage potentials, as well as a switch material benchmarking technique that utilizes a modular dielectric elastomer (artificial muscle) ring oscillator. The solid-state switching material was integrated into our oscillator, which self-started after 16 s and performed 5 oscillations at a frequency of 1.05 Hz with 3.25 kV DC input. Our materials-by-design approach for the nickel filled polydimethylsiloxane based switch has resulted in significant improvements over previous carbon grease-based switches in four key areas, namely, sharpness of switching behavior upon applied stretch, magnitude of electrical resistance change, ease of manufacture, and production rate. Switch lifetime was demonstrated to be in the range of tens to hundreds of cycles with the current process. An interesting and potentially useful strain-based switching hysteresis behavior is also presented. (C) 2016 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). C1 [Chau, Nixon; Anderson, Iain A.] Univ Auckland, Auckland Bioengn Inst, Biomimet Lab, Level 6,70 Symonds St, Auckland 1010, New Zealand. [Slipher, Geoffrey A.; Mrozek, Randy A.] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [O'Brien, Benjamin M.; Anderson, Iain A.] StretchSense Ltd, 27 Walls Rd, Auckland 1061, New Zealand. [Anderson, Iain A.] Univ Auckland, Sch Engn, Dept Engn Sci, Level 3,70 Symonds St, Auckland 1010, New Zealand. RP Slipher, GA (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM geoffrey.a.slipher.civ@mail.mil OI Slipher, Geoffrey/0000-0003-0532-0081 FU U.S. Army International Technology Center, Pacific (USAITC-Pac) [FA5209-14-P-0016] FX N.C. and I.A. acknowledge the U.S. Army International Technology Center, Pacific (USAITC-Pac) for providing funding for the work performed at the University of Auckland under Grant No. FA5209-14-P-0016. NR 19 TC 2 Z9 2 U1 6 U2 12 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAR 7 PY 2016 VL 108 IS 10 AR 103506 DI 10.1063/1.4943628 PG 5 WC Physics, Applied SC Physics GA DH7KV UT WOS:000372973600051 ER PT J AU Amato, R Miotto, O Woodrow, CJ Almagro-Garcia, J Sinha, I Campino, S Mead, D Drury, E Kekre, M Sanders, M Amambua-Ngwa, A Amaratunga, C Amenga-Etego, L Andrianaranjaka, V Apinjoh, T Ashley, E Auburn, S Awandare, GA Baraka, V Barry, A Boni, MF Borrmann, S Bousema, T Branch, O Bull, PC Chotivanich, K Conway, DJ Craig, A Day, NP Djimde, A Dolecek, C Dondorp, AM Drakeley, C Duffy, P Echeverry, DF Egwang, TG Fairhurst, RM Faiz, MA Fanello, CI Hien, TT Hodgson, A Imwong, M Ishengoma, D Lim, P Lon, C Marfurt, J Marsh, K Mayxay, M Michon, P Mobegi, V Mokuolu, OA Montgomery, J Mueller, I Kyaw, MP Newton, PN Nosten, F Noviyanti, R Nzila, A Ocholla, H Oduro, A Onyamboko, M Ouedraogo, JB Phyo, APP Plowe, C Price, RN Pukrittayakamee, S Randrianarivelojosia, M Ringwald, P Ruiz, L Saunders, D Shayo, A Siba, P Takala-Harrison, S Thanh, TNN Thathy, V Verra, F Wendler, J White, NJ Ye, H Cornelius, VJ Giacomantonio, R Muddyman, D Henrichs, C Malangone, C Jyothi, D Pearson, RD Rayner, JC McVean, G Rockett, KA Miles, A Vauterin, P Jeffery, B Manske, M Stalker, J Maclnnis, B Kwiatkowski, DP AF Amato, Roberto Miotto, Olivo Woodrow, Charles J. Almagro-Garcia, Jacob Sinha, Ipsita Campino, Susana Mead, Daniel Drury, Eleanor Kekre, Mihir Sanders, Mandy Amambua-Ngwa, Alfred Amaratunga, Chanaki Amenga-Etego, Lucas Andrianaranjaka, Voahangy Apinjoh, Tobias Ashley, Elizabeth Auburn, Sarah Awandare, Gordon A. Baraka, Vito Barry, Alyssa Boni, Maciej F. Borrmann, Steffen Bousema, Teun Branch, Oralee Bull, Peter C. Chotivanich, Kesinee Conway, David J. Craig, Alister Day, Nicholas P. Djimde, Abdoulaye Dolecek, Christiane Dondorp, Arjen M. Drakeley, Chris Duffy, Patrick Echeverry, Diego F. Egwang, Thomas G. Fairhurst, Rick M. Faiz, Md. Abul Fanello, Caterina I. Tran Tinh Hien Hodgson, Abraham Imwong, Mallika Ishengoma, Deus Lim, Pharath Lon, Chanthap Marfurt, Jutta Marsh, Kevin Mayxay, Mayfong Michon, Pascal Mobegi, Victor Mokuolu, Olugbenga A. Montgomery, Jacqui Mueller, Ivo Kyaw, Myat Phone Newton, Paul N. Nosten, Francois Noviyanti, Rintis Nzila, Alexis Ocholla, Harold Oduro, Abraham Onyamboko, Marie Ouedraogo, Jean-Bosco Phyo, Aung Pyae P. Plowe, Christopher Price, Ric N. Pukrittayakamee, Sasithon Randrianarivelojosia, Milijaona Ringwald, Pascal Ruiz, Lastenia Saunders, David Shayo, Alex Siba, Peter Takala-Harrison, Shannon Thanh, Thuy-Nhien N. Thathy, Vandana Verra, Federica Wendler, Jason White, Nicholas J. Ye, Htut Cornelius, Victoria J. Giacomantonio, Rachel Muddyman, Dawn Henrichs, Christa Malangone, Cinzia Jyothi, Dushyanth Pearson, Richard D. Rayner, Julian C. McVean, Gilean Rockett, Kirk A. Miles, Alistair Vauterin, Paul Jeffery, Ben Manske, Magnus Stalker, Jim Maclnnis, Bronwyn Kwiatkowski, Dominic P. CA MalariaGEN Plasmodium Falciparum C TI Genomic epidemiology of artemisinin resistant malaria SO ELIFE LA English DT Article ID PLASMODIUM-FALCIPARUM MALARIA; MOLECULAR POPULATION-GENETICS; SOFT SELECTIVE SWEEPS; SUB-SAHARAN AFRICA; SUBSTITUTION MATRICES; DRUG-RESISTANCE; ADAPTATION; MUTATIONS; EVOLUTION; CAMBODIA AB The current epidemic of artemisinin resistant Plasmodium falciparum in Southeast Asia is the result of a soft selective sweep involving at least 20 independent kelch13 mutations. In a large global survey, we find that kelchl3 mutations which cause resistance in Southeast Asia are present at low frequency in Africa. We show that African kelch13 mutations have originated locally, and that kelch13 shows a normal variation pattern relative to other genes in Africa, whereas in Southeast Asia there is a great excess of non-synonymous mutations, many of which cause radical amino-acid changes. Thus, kelch13 is not currently undergoing strong selection in Africa, despite a deep reservoir of variations that could potentially allow resistance to emerge rapidly. The practical implications are that public health surveillance for artemisinin resistance should not rely on kelchl3 data alone, and interventions to prevent resistance must account for local evolutionary conditions, shown by genomic epidemiology to differ greatly between geographical regions. C1 [Amato, Roberto; Miotto, Olivo; Almagro-Garcia, Jacob; Campino, Susana; Mead, Daniel; Drury, Eleanor; Kekre, Mihir; Sanders, Mandy; Giacomantonio, Rachel; Muddyman, Dawn; Malangone, Cinzia; Jyothi, Dushyanth; Pearson, Richard D.; Rayner, Julian C.; Rockett, Kirk A.; Miles, Alistair; Manske, Magnus; Stalker, Jim; Maclnnis, Bronwyn; Kwiatkowski, Dominic P.] Wellcome Trust Sanger Inst, Cambridge, England. [Amato, Roberto; Miotto, Olivo; Almagro-Garcia, Jacob; Wendler, Jason; Cornelius, Victoria J.; Giacomantonio, Rachel; Henrichs, Christa; Pearson, Richard D.; McVean, Gilean; Rockett, Kirk A.; Miles, Alistair; Vauterin, Paul; Jeffery, Ben; Kwiatkowski, Dominic P.] Wellcome Trust Ctr Human Genet, Ctr Genom & Global Hlth, Oxford, England. [Miotto, Olivo; Woodrow, Charles J.; Sinha, Ipsita; Ashley, Elizabeth; Day, Nicholas P.; Dondorp, Arjen M.; Fanello, Caterina I.; Imwong, Mallika; White, Nicholas J.] Mahidol Univ, Mahidol Oxford Trop Med Res Unit, Bangkok 10700, Thailand. [Woodrow, Charles J.; Boni, Maciej F.; Bull, Peter C.; Day, Nicholas P.; Dolecek, Christiane; Dondorp, Arjen M.; Tran Tinh Hien; Price, Ric N.; Thanh, Thuy-Nhien N.; White, Nicholas J.] Univ Oxford, Nuffield Dept Med, Ctr Trop Med & Global Hlth, Oxford, England. [Amambua-Ngwa, Alfred; Conway, David J.; Mobegi, Victor] MRC Unit, Banjul, Gambia. [Amaratunga, Chanaki; Duffy, Patrick; Fairhurst, Rick M.; Lim, Pharath] NIAID, NIH, Rockville, MD USA. [Amenga-Etego, Lucas; Tran Tinh Hien; Oduro, Abraham] Navrongo Hlth Res Ctr, Navrongo, Ghana. [Andrianaranjaka, Voahangy; Randrianarivelojosia, Milijaona] Inst Pasteur Madagascar, Malaria Res Unit, Antananarivo, Madagascar. [Apinjoh, Tobias] Univ Buea, Buea, Cameroon. [Auburn, Sarah; Marfurt, Jutta; Price, Ric N.] Menzies Sch Hlth Res, Global & Trop Hlth Div, Darwin, NT, Australia. [Auburn, Sarah; Marfurt, Jutta; Price, Ric N.] Charles Darwin Univ, Darwin, NT 0909, Australia. [Awandare, Gordon A.] Univ Ghana, Coll Basic & Appl Sci, West African Ctr Cell Biol Infect Pathogens, Legon, Ghana. [Baraka, Vito; Ishengoma, Deus] Natl Inst Med Res, Tanga Ctr, Tanga, Tanzania. [Baraka, Vito] Univ Antwerp, Dept Epidemiol, Int Hlth Unit, B-2020 Antwerp, Belgium. [Barry, Alyssa] Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Populat Hlth & Immun, Parkville, Vic 3050, Australia. [Barry, Alyssa; Mueller, Ivo] Univ Melbourne, Dept Med Biol, Carlton, Vic 3053, Australia. [Boni, Maciej F.] Univ Oxford, Ho Chi Minh City, Vietnam. [Borrmann, Steffen; Bull, Peter C.; Marsh, Kevin; Thathy, Vandana] Wellcome Trust Collaborat Res Program, Kenya Med Res Inst, Kilifi, Kenya. [Borrmann, Steffen] Univ Tubingen, Inst Trop Med, Tubingen, Germany. [Bousema, Teun; Conway, David J.; Drakeley, Chris; Mobegi, Victor; Verra, Federica] London Sch Hyg & Trop Med, London WC1, England. [Branch, Oralee] NYU, Sch Med, New York, NY USA. [Chotivanich, Kesinee; Pukrittayakamee, Sasithon] Mahidol Univ, Fac Trop Med, Bangkok, Thailand. [Craig, Alister] Univ Liverpool, Liverpool Sch Trop Med, Liverpool L3 5QA, Merseyside, England. [Djimde, Abdoulaye] Univ Bamako, Fac Med, Malaria Res & Training Ctr, Bamako, Mali. [Dolecek, Christiane; Tran Tinh Hien; Thanh, Thuy-Nhien N.] Univ Oxford, Clin Res Unit, Ho Chi Minh City, Vietnam. [Echeverry, Diego F.] Purdue Univ, Dept Entomol, W Lafayette, IN 47907 USA. [Echeverry, Diego F.] CIDEIM, Int Ctr Med Res & Training, Cali, Colombia. [Egwang, Thomas G.] Med Biotech Labs, Kampala, Uganda. [Faiz, Md. Abul] Malaria Res Grp, Dhaka, Bangladesh. [Faiz, Md. Abul] Dev Care Fdn, Dhaka, Bangladesh. [Lim, Pharath] Natl Ctr Parasitol Entomol & Malaria Control, Phnom Penh, Cambodia. [Lon, Chanthap; Saunders, David] Armed Forces Res Inst Med Sci, US Army Med Component, Dept Immunol & Med, Bangkok 10400, Thailand. [Mayxay, Mayfong; Newton, Paul N.] Lao Oxford Mahosot Hosp Wellcome Trust Res Unit, Vientiane, Lao PDR, England. [Mayxay, Mayfong] Univ Hlth Sci, Fac Postgrad Studies, Vientiane, Lao PDR, England. [Michon, Pascal] Divine Word Univ, Fac Med & Hlth Sci, Madang, Papua N Guinea. [Mokuolu, Olugbenga A.] Univ Ilorin, Dept Paediat & Child Hlth, Ilorin, Nigeria. [Montgomery, Jacqui] Penn State Univ, Dept Biol & Entomol, University Pk, PA 16802 USA. [Kyaw, Myat Phone; Ye, Htut] Minist Hlth, Dept Med Res Lower Myanmar, Yangon, Myanmar. [Nosten, Francois] Mahidol Univ, Mahido Oxford Trop Med Res Unit, Mae Sot, Thailand. [Nosten, Francois; Phyo, Aung Pyae P.] Shoklo Malaria Res Unit, Mae Sot, Thailand. [Noviyanti, Rintis] Eijkman Inst Mol Biol, Jakarta, Indonesia. [Nzila, Alexis] King Fahd Univ Petr & Minerals, Dept Biol, Dhahran, Saudi Arabia. [Ocholla, Harold] Malawi Liverpool Wellcome Trust Clin Res Programm, Lilongwe, Malawi. [Onyamboko, Marie] Univ Kinshasa, Kinshasa, Zaire. [Ouedraogo, Jean-Bosco] Direct Regionale Ouest, Inst Rech Sci Sante, Bobo Dioulasso, Burkina Faso. [Phyo, Aung Pyae P.] Shoklo Malaria Res Unit, Bangkok, Thailand. [Plowe, Christopher; Takala-Harrison, Shannon] Univ Maryland, Sch Med, Inst Global Hlth, Baltimore, MD 21201 USA. [Ringwald, Pascal] WHO, Global Malaria Programme, CH-1211 Geneva, Switzerland. [Ruiz, Lastenia] Univ Nacl Amazonia Peruana, Iquitos, Peru. [Shayo, Alex] Univ Dodoma, Dept Biotechnol & Bioinformat, Dodoma, Tanzania. [Siba, Peter] Papua New Guinea Inst Med Res, Madang, Papua N Guinea. RP Amato, R; Miotto, O; Kwiatkowski, DP (reprint author), Wellcome Trust Sanger Inst, Cambridge, England.; Amato, R; Miotto, O; Kwiatkowski, DP (reprint author), Wellcome Trust Ctr Human Genet, Ctr Genom & Global Hlth, Oxford, England.; Miotto, O (reprint author), Mahidol Univ, Mahidol Oxford Trop Med Res Unit, Bangkok 10700, Thailand. EM ra4@sanger.ac.uk; olivo@tropmedres.ac; dominic@sanger.ac.uk RI Bousema, Teun/N-3574-2014; OI Pyae Phyo, Aung/0000-0002-0383-9624; Miotto, Olivo/0000-0001-8060-6771; Mead, Daniel/0000-0001-7717-4330; Baraka, Vito /0000-0001-9694-9293; Conway, David/0000-0002-8711-3037; Craig, Alister/0000-0003-0914-6164; Jyothi, Dushyanth/0000-0002-0448-5303; Auburn, Sarah/0000-0002-4638-536X; Price, Richard/0000-0003-2000-2874; Rayner, Julian/0000-0002-9835-1014; Awandare, Gordon/0000-0002-8793-3641; Kwiatkowski, Dominic/0000-0002-5023-0176; Manske, Magnus/0000-0001-5916-0947 FU Wellcome Trust [98051, 090532/Z/09/Z, 90770, 0892375/H/09/Z]; Medical Research Council [G0600718]; Bill and Melinda Gates Foundation [OPP1040463]; National Institute of Allergy and Infectious Diseases FX Wellcome Trust WT Sanger Institute Core Funding, 98051 Roberto Amato Susana Campino Daniel Mead Eleanor Drury Mihir Kekre Mandy Sanders Victoria J Cornelius Rachel Giacomantonio Dawn Muddyman Cinzia Malangone Dushyanth Jyothi Richard D Pearson Julian C Rayner Kirk A Rockett Alistair Miles Heinrich M Manske Jim Stalker Bronwyn MacInnis Dominic P Kwiatkowski; Wellcome Trust WT Centre for Human Genetics Core Funding, 090532/Z/09/Z Roberto Amato Jacob Almagro-Garcia Victoria J Cornelius Rachel Giacomantonio Christa Henrichs Richard D Pearson Gilean McVean Kirk A Rockett Alistair Miles Paul Vauterin Ben Jeffery Dominic P Kwiatkowski; Wellcome Trust WT Stategic Award, 90770 Roberto Amato Olivo Miotto Jacob Almagro-Garcia Susana Campino Daniel Mead Eleanor Drury Mihir Kekre Lucas Amenga-Etego Tobias Apinjoh Abdoulaye Djimde Deus Ishengoma Milijaona Randrianarivelojosia Victoria J Cornelius Rachel Giacomantonio Dawn Muddyman Christa Henrichs Cinzia Malangone Dushyanth Jyothi Richard D Pearson Kirk A Rockett Alistair Miles Paul Vauterin Ben Jeffery Heinrich M Manske Jim Stalker Bronwyn MacInnis Dominic P Kwiatkowski; Medical Research Council Centre for Genomics and Global Health, G0600718 Roberto Amato Olivo Miotto Jacob Almagro-Garcia Lucas Amenga-Etego Tobias Apinjoh Abdoulaye Djimde Deus Ishengoma Victoria J Cornelius Rachel Giacomantonio Dawn Muddyman Gilean McVean Kirk A Rockett Alistair Miles Paul Vauterin Ben Jeffery Heinrich M Manske Jim Stalker Bronwyn MacInnis Dominic P Kwiatkowski; Bill and Melinda Gates Foundation Grant OPP1040463 Roberto Amato Olivo Miotto Charles J Woodrow Ipsita Sinha Elizabeth Ashley Nicholas P Day Arjen M Dondorp Mallika Imwong Nicholas J White Dominic P Kwiatkowski; Wellcome Trust WT Mahidol University Oxford Tropical Medicine Research Programme, 0892375/H/09/Z Olivo Miotto Charles J Woodrow Ipsita Sinha Elizabeth Ashley Nicholas P Day Arjen M Dondorp Caterina I Fanello Mayfong Mayxay Paul N Newton Francois Nosten Nicholas J White; National Institute of Allergy and Infectious Diseases Intramural Research Program Chanaki Amaratunga Rick M Fairhurst Pharath Lim NR 53 TC 2 Z9 3 U1 7 U2 19 PU ELIFE SCIENCES PUBLICATIONS LTD PI CAMBRIDGE PA SHERATON HOUSE, CASTLE PARK, CAMBRIDGE, CB3 0AX, ENGLAND SN 2050-084X J9 ELIFE JI eLife PD MAR 4 PY 2016 VL 5 AR e08714 DI 10.7554/eLife.08714 PG 29 WC Biology SC Life Sciences & Biomedicine - Other Topics GA DG2IH UT WOS:000371890100001 ER PT J AU Bornholdt, ZA Turner, HL Murin, CD Li, W Sok, D Souders, CA Piper, AE Goff, A Shamblin, JD Wollen, SE Sprague, TR Fusco, ML Pommert, KBJ Cavacini, LA Smith, HL Klempner, M Reimann, KA Krauland, E Gerngross, TU Wittrup, KD Saphire, EO Burton, DR Glass, PJ Ward, AB Walker, LM AF Bornholdt, Zachary A. Turner, Hannah L. Murin, Charles D. Li, Wen Sok, Devin Souders, Colby A. Piper, Ashley E. Goff, Arthur Shamblin, Joshua D. Wollen, Suzanne E. Sprague, Thomas R. Fusco, Marnie L. Pommert, Kathleen B. J. Cavacini, Lisa A. Smith, Heidi L. Klempner, Mark Reimann, Keith A. Krauland, Eric Gerngross, Tillman U. Wittrup, Karl D. Saphire, Erica Ollmann Burton, Dennis R. Glass, Pamela J. Ward, Andrew B. Walker, Laura M. TI Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak SO SCIENCE LA English DT Article ID MONOCLONAL-ANTIBODIES; NONHUMAN-PRIMATES; B-CELLS; INFECTION; REARRANGEMENTS; SELECTION; MACAQUES; COCKTAIL; DISEASE AB Antibodies targeting the Ebola virus surface glycoprotein (EBOV GP) are implicated in protection against lethal disease, but the characteristics of the human antibody response to EBOV GP remain poorly understood. We isolated and characterized 349 GP-specific monoclonal antibodies (mAbs) from the peripheral B cells of a convalescent donor who survived the 2014 EBOV Zaire outbreak. Remarkably, 77% of the mAbs neutralize live EBOV, and several mAbs exhibit unprecedented potency. Structures of selected mAbs in complex with GP reveal a site of vulnerability located in the GP stalk region proximal to the viral membrane. Neutralizing antibodies targeting this site show potent therapeutic efficacy against lethal EBOV challenge in mice. The results provide a framework for the design of new EBOV vaccine candidates and immunotherapies. C1 [Bornholdt, Zachary A.; Murin, Charles D.; Sok, Devin; Fusco, Marnie L.; Pommert, Kathleen B. J.; Saphire, Erica Ollmann; Burton, Dennis R.] Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA. [Turner, Hannah L.; Murin, Charles D.; Ward, Andrew B.] Scripps Res Inst, Dept Integrat Struct & Computat Biol, La Jolla, CA 92037 USA. [Li, Wen; Krauland, Eric; Gerngross, Tillman U.; Wittrup, Karl D.; Walker, Laura M.] Adimab, Lebanon, NH 03766 USA. [Souders, Colby A.; Cavacini, Lisa A.; Smith, Heidi L.; Klempner, Mark; Reimann, Keith A.] Univ Massachusetts, Sch Med, MassBiol, Boston, MA 02126 USA. [Piper, Ashley E.; Goff, Arthur; Shamblin, Joshua D.; Wollen, Suzanne E.; Sprague, Thomas R.; Glass, Pamela J.] US Army, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Burton, Dennis R.] MIT, Ragon Inst, Massachusetts Gen Hosp, Cambridge, MA 02142 USA. [Burton, Dennis R.] Harvard Univ, Cambridge, MA 02142 USA. RP Walker, LM (reprint author), Adimab, Lebanon, NH 03766 USA. EM laura.walker@adimab.com RI Ward, Andrew/F-9203-2014 OI Ward, Andrew/0000-0001-7153-3769 FU NIH/National Institute of Allergy and Infectious Diseases Center for Excellence in Translational Research [U19AI109762]; NSF; U.S. NIH grants [U19 AI109762, R01 AI067927]; Defense Advanced Research Projects Agency [DARPA-BAA-13-03]; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery [UM1AI100663]; [R01AI067927] FX We thank T. Boland and M. Vasquez for assistance with antibody sequence analysis, C. Williams and S. M. Eagol for assistance with figure preparation, R. Pejchal for providing helpful comments on the manuscript, and M. Haynes for assistance with flow cytometry. All of the IgGs were sequenced by Adimab's Molecular Core and produced by the High Throughput Expression group. BLI binding experiments were performed by Adimab's protein analytics group. The ZMapp cocktail mAb 2G4 was generously provided by Mapp Biopharmaceutical. The data presented in this manuscript are tabulated in the main paper and in the supplementary materials. GenBank accession numbers for the antibody variable-region gene sequences reported in this study can be found in table S7. The cryo-EM maps have been deposited to the Electron Microscopy Data Bank (accession numbers EMD-6586, EMD-6587, EMD-6588, and EMD-6589). E.O.S., Z.A.B., M.L.F., K.B.J.P., A.B.W., H.L.T., and C.D.M. acknowledge support from the NIH/National Institute of Allergy and Infectious Diseases Center for Excellence in Translational Research Grant U19AI109762, "Consortium for Immunotherapeutics Against Viral Hemorrhagic Fevers." E.O.S. was also supported by R01AI067927. C.D.M. was supported by a predoctoral fellowship from NSF. This study was supported in part by U.S. NIH grants U19 AI109762 and R01 AI067927 awarded to E.O.S. Research was funded in part by the Defense Advanced Research Projects Agency (DARPA-BAA-13-03). D.R.B. and D.S. acknowledge support from Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery Grant UM1AI100663. This is manuscript no. 29237 from The Scripps Research Institute. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army. NR 30 TC 9 Z9 9 U1 2 U2 13 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 0036-8075 EI 1095-9203 J9 SCIENCE JI Science PD MAR 4 PY 2016 VL 351 IS 6277 BP 1078 EP 1083 DI 10.1126/science.aad5788 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DF8HE UT WOS:000371597500043 PM 26912366 ER PT J AU Bunker, RJ Bunker, PL AF Bunker, Robert J. Bunker, Pamela Ligouri TI The modern state in epochal transition: The significance of irregular warfare, state deconstruction, and the rise of new warfighting entities beyond neo-medievalism SO SMALL WARS AND INSURGENCIES LA English DT Article DE space-time manipulation; proxies; irregular warfare; state deconstruction; Energy; mercenaries; new war; neo-medievalism; violent non-state actors; Westphalian states; epochal war AB This article is intended to serve as a 'think piece' which invites readers to view current perceived changes to the conduct of modern warfare in the broader historical light outlined by proponents of epochal change theory. Neo-medievalists have gone a step in this direction and posited that these changes represent the future of warfare and are evidence of a return, in a sense, to the primary tenets of political and social organization that existed in the period commonly referred to as the Middle Ages. The contention herein is that the answer gains more accuracy if one takes a much longer historical standpoint beginning with classical civilization and moving through the medieval period to our modern world. With regard to the present, this epochal warfare analysis projects that a shift from a Westphalian to post-Westphalian global system is underway. During this period of transition - as in the transition periods between epochs which have preceded it - the dominant state form undergoes a deinstitutionalization process, and war is less about traditional issues of state sovereignty, and instead increasingly over 'what the new form of social and political organization will be'. C1 [Bunker, Robert J.] US Army, War Coll, Strateg Studies Inst, Carlisle, PA USA. [Bunker, Pamela Ligouri] Small Wars Journal El Ctr, New York, NY USA. RP Bunker, RJ (reprint author), US Army, War Coll, Strateg Studies Inst, Carlisle, PA USA. EM robert.bunker@cgu.edu NR 32 TC 0 Z9 0 U1 3 U2 6 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0959-2318 EI 1743-9558 J9 SMALL WAR INSUR JI Small War Insur. PD MAR 3 PY 2016 VL 27 IS 2 SI SI BP 325 EP 344 DI 10.1080/09592318.2015.1129168 PG 20 WC International Relations SC International Relations GA DH4LI UT WOS:000372757100008 ER PT J AU Williamson, CHD Sahl, JW Smith, TJ Xie, G Foley, BT Smith, LA Fernandez, RA Lindstrom, M Korkeala, H Keim, P Foster, J Hill, K AF Williamson, Charles H. D. Sahl, Jason W. Smith, Theresa J. Xie, Gary Foley, Brian T. Smith, Leonard A. Fernandez, Rafael A. Lindstrom, Miia Korkeala, Hannu Keim, Paul Foster, Jeffrey Hill, Karen TI Comparative genomic analyses reveal broad diversity in botulinum-toxin-producing Clostridia SO BMC GENOMICS LA English DT Article DE Clostridium botulinum; Botulinum neurotoxin; Whole genome sequence; Comparative genomics ID FRAGMENT LENGTH POLYMORPHISM; FIELD GEL-ELECTROPHORESIS; NEUROTOXIN COMPLEX GENES; DNA-SEQUENCING DATA; GROUP-I; INFANT BOTULISM; E STRAINS; PHYLOGENETIC ANALYSIS; HIGH-THROUGHPUT; FOOD AB Background: Clostridium botulinum is a diverse group of bacteria characterized by the production of botulinum neurotoxin. Botulinum neurotoxins are classified into serotypes (BoNT/A-G), which are produced by six species/Groups of Clostridia, but the genetic background of the bacteria remains poorly understood. The purpose of this study was to use comparative genomics to provide insights into the genetic diversity and evolutionary history of bacteria that produce the potent botulinum neurotoxin. Results: Comparative genomic analyses of over 170 Clostridia genomes, including our draft genome assemblies for 59 newly sequenced Clostridia strains from six continents and publicly available genomic data, provided in-depth insights into the diversity and distribution of BoNT-producing bacteria. These newly sequenced strains included Group I and II strains that express BoNT/A,/B,/E, or/F as well as bivalent strains. BoNT-producing Clostridia and closely related Clostridia species were delineated with a variety of methods including 16S rRNA gene, concatenated marker genes, core genome and concatenated multi-locus sequencing typing (MLST) gene phylogenies that related whole genome sequenced strains to publicly available strains and sequence types. These analyses illustrated the phylogenetic diversity in each Group and the diversity of genomic backgrounds that express the same toxin type or subtype. Comparisons of the botulinum neurotoxin genes did not identify novel toxin types or variants. Conclusions: This study represents one of the most comprehensive analyses of whole genome sequence data for Group I and II BoNT-producing strains. Read data and draft genome assemblies generated for 59 isolates will be a resource to the research community. Core genome phylogenies proved to be a powerful tool for differentiating BoNT-producing strains and can provide a framework for the study of these bacteria. Comparative genomic analyses of Clostridia species illustrate the diversity of botulinum-neurotoxin-producing strains and the plasticity of the genomic backgrounds in which bont genes are found. C1 [Williamson, Charles H. D.; Sahl, Jason W.; Keim, Paul; Foster, Jeffrey] Univ Arizona, Ctr Microbial Genet & Genom, Flagstaff, AZ 86011 USA. [Smith, Theresa J.] US Army, Med Res Inst Infect Dis, Mol & Translat Sci Div, Ft Detrick, MD 21702 USA. [Xie, Gary; Hill, Karen] Los Alamos Natl Lab, Biosci Div, POB 1663, Los Alamos, NM 87545 USA. [Foley, Brian T.] Los Alamos Natl Lab, Div Theoret, Los Alamos, NM USA. [Smith, Leonard A.] US Army, Med Res & Mat Command, Med Countermeasures Technol, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Fernandez, Rafael A.] Univ Nacl Cuyo, Fac Ciencias Med, Dept Patol, Area Microbiol,Ctr Univ, RA-5500 Mendoza, Argentina. [Lindstrom, Miia; Korkeala, Hannu] Univ Helsinki, Dept Food Hyg & Environm Hlth, Helsinki, Finland. [Foster, Jeffrey] Univ New Hampshire, Dept Mol Cellular & Biomed Sci, Durham, NH 03824 USA. RP Keim, P; Foster, J (reprint author), Univ Arizona, Ctr Microbial Genet & Genom, Flagstaff, AZ 86011 USA.; Hill, K (reprint author), Los Alamos Natl Lab, Biosci Div, POB 1663, Los Alamos, NM 87545 USA.; Foster, J (reprint author), Univ New Hampshire, Dept Mol Cellular & Biomed Sci, Durham, NH 03824 USA. EM Paul.Keim@nau.edu; Jeff.Foster@unh.edu; khill@lanl.gov OI Foster, Jeffrey/0000-0001-8235-8564; xie, gary/0000-0002-9176-924X FU U.S. Department of Homeland Security Science and Technology [HSHQDC 10 C 00139, DHS-2010-ST-108-000019]; Arizona's Technology Research Initiative Fund; Arizona's Technology and Research Initiative Fund FX The work was supported by the U.S. Department of Homeland Security Science and Technology Directorate via awards HSHQDC 10 C 00139 and DHS-2010-ST-108-000019. CHDW was supported by funding from Arizona's Technology Research Initiative Fund. Some of the computational analyses were run on Northern Arizona University's Monsoon computing cluster, also funded by Arizona's Technology and Research Initiative Fund. The authors would like to thank Dr. C. Shone of Public Health England, Salisbury, UK for his kind gift of DNA from the Mauritius bont/A2 strain, and Dr. J. Rood of Monash University, Melbourne, Australia for providing C. botulinum strains for analyses. Opinions, interpretations, conclusions and recommendations are those of the authors and not necessarily endorsed by the U.S. Army. NR 104 TC 5 Z9 5 U1 8 U2 22 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2164 J9 BMC GENOMICS JI BMC Genomics PD MAR 3 PY 2016 VL 17 AR 180 DI 10.1186/s12864-016-2502-z PG 20 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA DF8GI UT WOS:000371595000006 PM 26939550 ER PT J AU Rice, BM Byrd, EFC AF Rice, Betsy M. Byrd, Edward F. C. TI Theoretical Study of Shocked Formic Acid: Born-Oppenheimer MD Calculations of the Shock Hugoniot and Early-Stage Chemistry SO JOURNAL OF PHYSICAL CHEMISTRY B LA English DT Article ID MOLECULAR-DYNAMICS SIMULATIONS; HIGH-PRESSURE; INITIAL DECOMPOSITION; ENERGETIC MATERIALS; BETA-HMX; RESPONSES; CURVE AB Quantum and classical molecular dynamics simulations are used to explore whether chemical reactivity of shocked formic acid occurs at pressures greater than 15 GPa, a question arising from results of different shock compression experiments. The classical molecular dynamics simulations were performed using a quantum-based nonreactive pair additive interaction potential whereas the full resolution quantum mechanical molecular dynamics simulations allow chemical reactions. Although the shock Hugoniot curve calculated using nonreactive classical MD for fon-Mc acid is in reasonable agreement with one set of experimental results, shock Hugoniot points calculated using Born Oppenheimer MD at 30 GPa are in agreement with the set of experimental data that suggests chemical reactivity at these elevated temperatures and pressures. Examination of atomic positions throughout the Born Oppenheimer MD trajectories clearly indicates extensive and complex chemical reaction, chiefly involving hydrogen-atom-transfer and intermolecular complexation. C1 [Rice, Betsy M.; Byrd, Edward F. C.] US Army, Res Lab ARL, Aberdeen, MD 21005 USA. RP Rice, BM (reprint author), US Army, Res Lab ARL, Aberdeen, MD 21005 USA. EM betsy.rice.civ@mail.mil FU DoD High Performance Computing Modernization Program Software Application Institute for Multi-Scale Reactive Modeling of Insensitive Munitions FX This work was partially supported by the DoD High Performance Computing Modernization Program Software Application Institute for Multi-Scale Reactive Modeling of Insensitive Munitions (2008-2014). NR 38 TC 0 Z9 0 U1 5 U2 12 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1520-6106 J9 J PHYS CHEM B JI J. Phys. Chem. B PD MAR 3 PY 2016 VL 120 IS 8 BP 1711 EP 1719 DI 10.1021/acs.jpcb.5b08845 PG 9 WC Chemistry, Physical SC Chemistry GA DF7UI UT WOS:000371562700034 PM 26654191 ER PT J AU Wang, XT Byrd, M Jacobs, K AF Wang, Xiaoting Byrd, Mark Jacobs, Kurt TI Minimal noise subsystems SO PHYSICAL REVIEW LETTERS LA English DT Article ID DECOHERENCE-FREE SUBSPACES; ERROR-CORRECTING CODES; QUANTUM COMPUTATION; FIDELITY; STATES; MEMORY AB A system subjected to noise contains a decoherence-free subspace or subsystem (DFS) only if the noise possesses an exact symmetry. Here we consider noise models in which a perturbation breaks a symmetry of the noise, so that if S is a DFS under a given noise process it is no longer so under the new perturbed noise process. We ask whether there is a subspace or subsystem that is more robust to the perturbed noise than S. To answer this question we develop a numerical method that allows us to search for subspaces or subsystems that are maximally robust to arbitrary noise processes. We apply this method to a number of examples, and find that a subsystem that is a DFS is often not the subsystem that experiences minimal noise when the symmetry of the noise is broken by a perturbation. We discuss which classes of noise have this property. C1 [Wang, Xiaoting] Louisiana State Univ, Hearne Inst Theoret Phys, Baton Rouge, LA 70803 USA. [Wang, Xiaoting] MIT, Elect Res Lab, Cambridge, MA 02139 USA. [Wang, Xiaoting; Jacobs, Kurt] Univ Massachusetts, Dept Phys, Boston, MA 02125 USA. [Byrd, Mark] So Illinois Univ, Dept Phys, Carbondale, IL 62901 USA. [Byrd, Mark] So Illinois Univ, Dept Comp Sci, Carbondale, IL 62901 USA. [Jacobs, Kurt] US Army Res Lab, Computat & Informat Sci Directorate, Adelphi, MD 20783 USA. RP Wang, XT (reprint author), Louisiana State Univ, Hearne Inst Theoret Phys, Baton Rouge, LA 70803 USA.; Wang, XT (reprint author), MIT, Elect Res Lab, Cambridge, MA 02139 USA.; Wang, XT (reprint author), Univ Massachusetts, Dept Phys, Boston, MA 02125 USA. EM xiaoting@lsu.edu FU NSF [PHY-0902906, PHY-1005571, CCF-1350397]; Intelligence Advanced Research Projects Activity (IARPA) via Department of Interior National Business Center [D11PC20168] FX K. J. and X. W. were partially supported by the NSF Projects No. PHY-0902906, K. J. by No. PHY-1005571, and X. W. by No. CCF-1350397. All the authors were partially supported by the Intelligence Advanced Research Projects Activity (IARPA) via Department of Interior National Business Center Contract No. D11PC20168. NR 39 TC 0 Z9 0 U1 2 U2 4 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0031-9007 EI 1079-7114 J9 PHYS REV LETT JI Phys. Rev. Lett. PD MAR 3 PY 2016 VL 116 IS 9 AR 090404 DI 10.1103/PhysRevLett.116.090404 PG 5 WC Physics, Multidisciplinary SC Physics GA DF5VC UT WOS:000371419600002 PM 26991160 ER PT J AU Van Ombergen, A Lawson, BD Wuyts, FL AF Van Ombergen, Angelique Lawson, Ben D. Wuyts, Floris L. TI Motion sickness and sopite syndrome associated with parabolic flights: a case report SO INTERNATIONAL JOURNAL OF AUDIOLOGY LA English DT Article DE Motion sickness; sopite syndrome; parabolic flight; vestibular system ID INTRANASAL SCOPOLAMINE; SUSCEPTIBILITY; SCALE AB Objective: The purpose of this paper was to provide an extensive description of a case of sopite syndrome, a manifestation of motion sickness scarcely described in the literature.Design: The following questionnaires were used to assess sopite syndrome symptoms pre, during and post parabolic flight; Misery Scale rate, Positive and Negative Affect Scale, the Motion Sickness Assessment Questionnaire and the Epworth Sleepiness Scale.Study sample: Case report of a 35-year old female compared to a control group (n=26).Results: We describe of sopite syndrome during parabolic flight. The subject reported drowsiness and she noted mood changes such as irritation and annoyance. Furthermore, she was not able to perform her assigned task. Her symptoms escalated into extreme fatigue and the inability to stay awake. Nauseogenic symptoms improved, but soporific symptoms persisted for several hours after the motion stimulus (i.e. parabolic flight).Conclusions: This case points towards the need for controlled studies to assess the prevalence of this syndrome among the general population and select groups. Future research should focus on developing tests for personnel screening and explore treatment options. C1 [Van Ombergen, Angelique; Wuyts, Floris L.] Univ Antwerp, Res Ctr Equilibrium & Aerosp AUREA, Groenenborgerlaan 171, B-2020 Antwerp, Belgium. [Lawson, Ben D.] US Army Aeromed Res Lab, Ft Rucker, AL 36362 USA. RP Van Ombergen, A (reprint author), Univ Antwerp, Res Ctr Equilibrium & Aerosp AUREA, Groenenborgerlaan 171, B-2020 Antwerp, Belgium. EM angelique.vanombergen@uantwerp.be FU European Space Agency [ISLRA 2009-1062, LS60-3]; Belgian Science Policy (Belspo, Prodex); Research Foundation Flanders (Belgium - FWO Vlaanderen) [11U6414N, 11U6416N] FX The authors would like to thank all participants for their cooperation and the following coordinating persons: Vladimir Pletser (European Space Agency), Alexandra Jaquement (Novespace, Bordeaux, France) & Frederic Gai (Novespace, Bordeaux, France). This work was supported by the European Space Agency (ISLRA 2009-1062 and LS60-3), Belgian Science Policy (Belspo, Prodex) and the Research Foundation Flanders (Belgium - FWO Vlaanderen, grant 11U6414N and 11U6416N). Angelique Van Ombergen is a research fellow for FWO Vlaanderen. NR 31 TC 2 Z9 2 U1 2 U2 4 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1499-2027 EI 1708-8186 J9 INT J AUDIOL JI Int. J. Audiol. PD MAR 3 PY 2016 VL 55 IS 3 BP 189 EP 194 DI 10.3109/14992027.2015.1111526 PG 6 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA DE5BO UT WOS:000370646000008 PM 26624575 ER PT J AU Ndungo, E Herbert, AS Raaben, M Obernosterer, G Biswas, R Miller, EH Wirchnianski, AS Carette, JE Brummelkamp, TR Whelan, SP Dye, JM Chandran, K AF Ndungo, Esther Herbert, Andrew S. Raaben, Matthijs Obernosterer, Gregor Biswas, Rohan Miller, Emily Happy Wirchnianski, Ariel S. Carette, Jan E. Brummelkamp, Thijn R. Whelan, Sean P. Dye, John M. Chandran, Kartik TI A Single Residue in Ebola Virus Receptor NPC1 Influences Cellular Host Range in Reptiles SO MSPHERE LA English DT Article DE Ebola virus; NPC1; Niemann-Pick C1; endosomal receptor; filovirus; intracellular receptor; reptiles; viral receptor; virus-host interactions ID NIEMANN-PICK C1; HEMORRHAGIC-FEVER ARENAVIRUSES; CROSS-SPECIES TRANSMISSION; ENTRY REQUIRES; MARBURG VIRUS; GLYCOPROTEIN; INFECTION; RECOGNITION; IDENTIFICATION; CORONAVIRUS AB Filoviruses are the causative agents of an increasing number of disease outbreaks in human populations, including the current unprecedented Ebola virus disease (EVD) outbreak in western Africa. One obstacle to controlling these epidemics is our poor understanding of the host range of filoviruses and their natural reservoirs. Here, we investigated the role of the intracellular filovirus receptor, Niemann-Pick C1 (NPC1) as a molecular determinant of Ebola virus (EBOV) host range at the cellular level. Whereas human cells can be infected by EBOV, a cell line derived from a Russell's viper (Daboia russellii) (VH-2) is resistant to infection in an NPC1-dependent manner. We found that VH-2 cells are resistant to EBOV infection because the Russell's viper NPC1 ortholog bound poorly to the EBOV spike glycoprotein (GP). Analysis of panels of viper-human NPC1 chimeras and point mutants allowed us to identify a single amino acid residue in NPC1, at position 503, that bidirectionally influenced both its binding to EBOV GP and its viral receptor activity in cells. Significantly, this single residue change perturbed neither NPC1's endosomal localization nor its housekeeping role in cellular cholesterol trafficking. Together with other recent work, these findings identify sequences in NPC1 that are important for viral receptor activity by virtue of their direct interaction with EBOV GP and suggest that they may influence filovirus host range in nature. Broader surveys of NPC1 orthologs from vertebrates may delineate additional sequence polymorphisms in this gene that control susceptibility to filovirus infection. IMPORTANCE Identifying cellular factors that determine susceptibility to infection can help us understand how Ebola virus is transmitted. We asked if the EBOV receptor Niemann-Pick C1 (NPC1) could explain why reptiles are resistant to EBOV infection. We demonstrate that cells derived from the Russell's viper are not susceptible to infection because EBOV cannot bind to viper NPC1. This resistance to infection can be mapped to a single amino acid residue in viper NPC1 that renders it unable to bind to EBOV GP. The newly solved structure of EBOV GP bound to NPC1 confirms our findings, revealing that this residue dips into the GP receptor-binding pocket and is therefore critical to the binding interface. Consequently, this otherwise well-conserved residue in vertebrate species influences the ability of reptilian NPC1 proteins to bind to EBOV GP, thereby affecting viral host range in reptilian cells. C1 [Ndungo, Esther; Biswas, Rohan; Miller, Emily Happy; Chandran, Kartik] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10467 USA. [Herbert, Andrew S.; Wirchnianski, Ariel S.; Dye, John M.] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Raaben, Matthijs; Whelan, Sean P.] Harvard Med Sch, Dept Microbiol & Immunobiol, Boston, MA USA. [Raaben, Matthijs; Obernosterer, Gregor; Brummelkamp, Thijn R.] Netherlands Canc Inst, Amsterdam, Netherlands. [Carette, Jan E.] Stanford Univ, Dept Microbiol & Immunol, Sch Med, Stanford, CA 94305 USA. RP Chandran, K (reprint author), Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10467 USA.; Dye, JM (reprint author), US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. EM john.m.dye1.civ@mail.mil; kartik.chandran@einstein.yu.edu OI Ndungo, Esther/0000-0002-9975-7032 FU HHS \ National Institutes of Health (NIH) [R01 AI088027, R01 AI101436]; DOD \ Defense Threat Reduction Agency (DTRA) [CB3948] FX This work, including the efforts of Esther Ndungo, Rohan Biswas, Emily Happy Miller, and Kartik Chandran, was funded by HHS vertical bar National Institutes of Health (NIH) (R01 AI088027 and R01 AI101436). This work, including the efforts of Andrew S. Herbert, Ariel S. Wirchnianski, and John M. Dye, was funded by DOD vertical bar Defense Threat Reduction Agency (DTRA) (CB3948). NR 40 TC 1 Z9 1 U1 1 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 2379-5042 J9 MSPHERE JI mSphere PD MAR-APR PY 2016 VL 1 IS 2 AR UNSP e00007-16 DI 10.1128/mSphere.00007-16 PG 15 WC Microbiology SC Microbiology GA EI6DH UT WOS:000392584700002 ER PT J AU Mayer, C AF Mayer, Chris TI SUSTAINING INNOVATION IN THE MIDST OF SUCCESS SO JOURNAL OF LEADERSHIP STUDIES LA English DT Article AB It seems strange to claim that it is dangerous for organizations to achieve the success they seek; however, there are numerous cases of successful organizations facing decline soon after achieving success. This often occurs because these organizations fall into the trap of focusing too much on execution once they achieve success, which causes them to neglect the innovative approach that enabled achieving success in the first place. To avoid this trap, leaders must ensure that their organizations have a clearly identified and transformative purpose that guides organizational member work and inspires them to improve. The leader must also ensure that there is a well-established and understood process for improvement that facilitates learning and innovation. Finally, the leader must model, and organizational policies must reflect, the proper balance between execution and innovation. C1 [Mayer, Chris] US Mil Acad, Philosophy, West Point, NY 10996 USA. [Mayer, Chris] US Mil Acad, Strategy Policy & Assessment, West Point, NY 10996 USA. [Mayer, Chris] US Army, Arlington, VA USA. RP Mayer, C (reprint author), US Mil Acad, Philosophy, West Point, NY 10996 USA.; Mayer, C (reprint author), US Mil Acad, Strategy Policy & Assessment, West Point, NY 10996 USA. EM christopher.mayer@usma.edu NR 7 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1935-2611 EI 1935-262X J9 J LEADERSH STUD JI J. Leadersh. Stud. PD SPR PY 2016 VL 10 IS 1 BP 73 EP 75 DI 10.1002/jls.21453 PG 3 WC Management SC Business & Economics GA EB2BM UT WOS:000387161900022 ER PT J AU Fadel, TR Farrell, DF Friedersdorf, LE Griep, MH Hoover, MD Meador, MA Meyyappan, M AF Fadel, Tarek R. Farrell, Dorothy F. Friedersdorf, Lisa E. Griep, Mark H. Hoover, Mark D. Meador, Michael A. Meyyappan, M. TI Toward the Responsible Development and Commercialization of Sensor Nanotechnologies SO ACS SENSORS LA English DT Article DE nanosensors; engineered nanomaterials; commercialization; data quality; life cycle ID CARBON NANOTUBES; NANOPORE SENSORS; DNA; NANOPARTICLES; GRAPHENE; NANOMATERIALS; NANOSENSORS; TRANSISTOR; MOLECULES; SYSTEM AB Nanotechnology-enabled sensors (or nano sensors) will play an important role in enabling the progression toward ubiquitous information systems as the Internet of Things (IoT) emerges. Nanosensors offer new, miniaturized solutions in physiochemical and biological sensing that enable increased sensitivity, specificity, and multiplexing capability, all with the compelling economic drivers of low cost and high-energy efficiency. In the United States, Federal agencies participating in the National Nano technology Initiative (NNI) "Nanotechnology for Sensors and Sensors for Nanotechnology: Improving and Protecting Health, Safety, and the Environment" Nanotechnology Signature Initiative (the Sensors NSI), address both the opportunity of using nanotechnology to advance sensor development and the challenges of developing sensors to keep pace with the increasingly widespread use of engineered nanomaterials. This perspective article will introduce and provide background on the NNI signature initiative on sensors. Recent efforts by the Sensors NSI aimed at promoting the successful development and commercialization of nanosensors will be reviewed and examples of sensor nanotechnologies will be highlighted. Future directions and critical challenges for sensor development will also be discussed. C1 [Fadel, Tarek R.; Friedersdorf, Lisa E.; Meador, Michael A.] Natl Nanotechnol Coordinat Off, 4201 Wilson Blvd,Suite 405, Arlington, VA 22230 USA. [Farrell, Dorothy F.] NCI, NIH, 31 Ctr Dr,10A52, Bethesda, MD 20892 USA. [Griep, Mark H.] US Army, Res Lab, Aberdeen, MD 21005 USA. [Hoover, Mark D.] NIOSH, 1095 Willowdale Rd, Morgantown, WV 26505 USA. [Meyyappan, M.] NASA, Ames Res Ctr, Ctr Nanotechnol, Moffett Field, CA 94035 USA. RP Fadel, TR (reprint author), Natl Nanotechnol Coordinat Off, 4201 Wilson Blvd,Suite 405, Arlington, VA 22230 USA. EM TFadel@nnco.nano.gov NR 76 TC 1 Z9 1 U1 6 U2 6 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 2379-3694 J9 ACS SENSORS JI ACS Sens. PD MAR PY 2016 VL 1 IS 3 BP 207 EP 216 DI 10.1021/acssensors.5b00279 PG 10 WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology SC Chemistry; Science & Technology - Other Topics GA DY9OT UT WOS:000385464400002 PM 28261665 ER PT J AU Ahrari, EM AF Ahrari, Ehsan M. TI Is the American Century Over? SO MEDITERRANEAN QUARTERLY-A JOURNAL OF GLOBAL ISSUES LA English DT Book Review C1 [Ahrari, Ehsan M.] US Army, War Coll, Strateg Studies Inst, Carlisle, PA 17013 USA. RP Ahrari, EM (reprint author), US Army, War Coll, Strateg Studies Inst, Carlisle, PA 17013 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU DUKE UNIV PRESS PI DURHAM PA 905 W MAIN ST, STE 18-B, DURHAM, NC 27701 USA SN 1047-4552 EI 1527-1935 J9 MEDITERR Q JI Mediterr. Q. PD MAR PY 2016 VL 27 IS 1 BP 122 EP 125 DI 10.1215/10474552-3488093 PG 4 WC International Relations SC International Relations GA DZ1PT UT WOS:000385611000008 ER PT J AU Merefield, DC Beckham, J AF Merefield, David C. Beckham, Jerry TI Cardiac arrest in Antarctica-a successful outcome SO JOURNAL OF TRAVEL MEDICINE LA English DT Letter C1 [Merefield, David C.] Coral Coast Anaesthesia, Bundaberg, Qld, Australia. Tripler Army Med Ctr, Dept Emergency Med, Honolulu, HI 96859 USA. Univ Hawaii Honolulu, John A Burns Sch Med, Dept Surg, Honolulu, HI USA. RP Merefield, DC (reprint author), Coral Coast Anaesthesia, Bundaberg, Qld, Australia. NR 3 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1195-1982 EI 1708-8305 J9 J TRAVEL MED JI J. Travel Med. PD MAR PY 2016 VL 23 IS 3 AR taw015 DI 10.1093/jtm/taw015 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA DV9IV UT WOS:000383255000016 ER PT J AU Summers, SM Chin, EJ Long, BJ Grisell, RD Knight, JG Grathwohl, KW Ritter, JL Morgan, JD Salinas, J Blackbourne, LH AF Summers, Shane M. Chin, Eric J. Long, Brit J. Grisell, Ronald D. Knight, John G. Grathwohl, Kurt W. Ritter, John L. Morgan, Jeffrey D. Salinas, Jose Blackbourne, Lorne H. TI Computerized Diagnostic Assistant for the Automatic Detection of Pneumothorax on Ultrasound: A Pilot Study SO WESTERN JOURNAL OF EMERGENCY MEDICINE LA English DT Article DE Ultrasound; Pneumothorax; Automated; Diagnosis; Bedside ID BREAST ULTRASOUND; AIDED DIAGNOSIS; CLASSIFICATION; CANCER; IMAGES; SYSTEM; ULTRASONOGRAPHY; METAANALYSIS; MAMMOGRAPHY; PERFORMANCE AB Introduction: Bedside thoracic ultrasound (US) can rapidly diagnose pneumothorax (PTX) with improved accuracy over the physical examination and without the need for chest radiography (CXR); however, US is highly operator dependent. A computerized diagnostic assistant was developed by the United States Army Institute of Surgical Research to detect PTX on standard thoracic US images. This computer algorithm is designed to automatically detect sonographic signs of PTX by systematically analyzing B-mode US video clips for pleural sliding and M-mode still images for the seashore sign. This was a pilot study to estimate the diagnostic accuracy of the PTX detection computer algorithm when compared to an expert panel of US trained physicians. Methods: This was a retrospective study using archived thoracic US obtained on adult patients presenting to the emergency department (ED) between 5/23/2011 and 8/6/2014. Emergency medicine residents, fellows, attending physicians, physician assistants, and medical students performed the US examinations and stored the images in the picture archive and communications system (PACS). The PACS was queried for all ED bedside US examinations with reported positive PTX during the study period along with a random sample of negatives. The computer algorithm then interpreted the images, and we compared the results to an independent, blinded expert panel of three physicians, each with experience reviewing over 10,000 US examinations. Results: Query of the PACS system revealed 146 bedside thoracic US examinations for analysis. Thirteen examinations were indeterminate and were excluded. There were 79 true negatives, 33 true positives, 9 false negatives, and 12 false positives. The test characteristics of the algorithm when compared to the expert panel were sensitivity 79% (95 % CI [63-89]) and specificity 87% (95% CI [77-93]). For the 20 images scored as highest quality by the expert panel, the algorithm demonstrated 100% sensitivity (95% CI [56-100]) and 92% specificity (95% CI [62-100]). Conclusion: This novel computer algorithm has potential to aid clinicians with the identification of the sonographic signs of PTX in the absence of expert physician sonographers. Further refinement and training of the algorithm is still needed, along with prospective validation, before it can be utilized in clinical practice. C1 [Summers, Shane M.; Chin, Eric J.; Long, Brit J.; Knight, John G.; Morgan, Jeffrey D.] Brooke Army Med Ctr, Dept Emergency Med, 3851 Roger Brooke Dr, San Antonio, TX 78234 USA. [Ritter, John L.] Brooke Army Med Ctr, Dept Radiol, San Antonio, TX USA. [Grathwohl, Kurt W.] Brooke Army Med Ctr, Dept Pulm Crit Care, San Antonio, TX USA. [Grisell, Ronald D.; Salinas, Jose] US Army, Inst Surg Res, San Antonio, TX USA. [Blackbourne, Lorne H.] US Army, Med Dept Ctr & Sch, Ft Sam Houston, TX USA. RP Long, BJ (reprint author), Brooke Army Med Ctr, Dept Emergency Med, 3851 Roger Brooke Dr, San Antonio, TX 78234 USA. EM brit.long@yahoo.com NR 24 TC 1 Z9 1 U1 0 U2 1 PU WESTJEM PI ORANGE PA C/O SHAHRAM LOTFIPOUR, MD, MPH, 333 CITY BLVD W STE 640, RT 128-01, ORANGE, CA 92868 USA SN 1936-900X EI 1936-9018 J9 WEST J EMERG MED JI West. J. Emerg. Med. PD MAR PY 2016 VL 17 IS 4 BP 209 EP 215 DI 10.5811/westjem.2016.1.28087 PG 7 WC Emergency Medicine SC Emergency Medicine GA DV3QE UT WOS:000382837100021 PM 26973754 ER PT J AU Crocker, FH Blakeney, GA Jung, CM AF Crocker, Fiona H. Blakeney, G. Alon Jung, Carina M. TI Complete Degradation of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) by a Co-Culture of Gordonia sp. KTR9 and Methylobacterium sp. JS178 SO REMEDIATION-THE JOURNAL OF ENVIRONMENTAL CLEANUP COSTS TECHNOLOGIES & TECHNIQUES LA English DT Article ID BACTERIAL CONSORTIUM; EXPLOSIVE HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE; BIODEGRADATION; STRAIN; MINERALIZATION; METABOLITES; CATABOLISM; TOXICITY; PATHWAYS; ATRAZINE AB The presence of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) in soil and groundwater is a major contamination issue at many military facilities around the world. Gordonia sp. KTR9 metabolizes RDX as a nitrogen source for growth producing 4-nitro-2,4-diazabutanal (NDAB) as a dead-end product. Methylobacterium sp. strain JS178 degrades NDAB as a sole source of nitrogen for growth. A mixed culture of strains KTR9 and JS178 was able to completely degrade RDX. There was no difference in rate of RDX degradation by KTR9 alone or in co-culture with JS178. The first-order degradation coefficients of RDX and NDAB in the co-culture were 0.08 hr(-1) and 0.002 hr(-1), respectively. In the co-culture that initially contained RDX plus NDAB, strain JS178 degraded the NDAB that was produced by KTR9 as shown by a decrease in the molar yield of NDAB (from RDX) from 1.0 to -0.11. Co-cultures of strains KTR9 and JS178 could be used to promote complete degradation of RDX in soils or groundwater. (C) 2016 Wiley Periodicals, Inc. C1 [Crocker, Fiona H.] Engn Res & Dev Ctr Vicksburg, Environm Lab, Vicksburg, MS 39180 USA. [Blakeney, G. Alon] Bennett Aerosp Inc, Vicksburg, MS USA. [Jung, Carina M.] Engn Res & Dev Ctr Vicksburg, Vicksburg, MS USA. RP Crocker, FH (reprint author), Engn Res & Dev Ctr Vicksburg, Environm Lab, Vicksburg, MS 39180 USA. NR 23 TC 0 Z9 0 U1 3 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1051-5658 EI 1520-6831 J9 REMEDIATION JI Remediation PD SPR PY 2016 VL 26 IS 2 BP 51 EP 58 DI 10.1002/rem.21457 PG 8 WC Engineering, Environmental SC Engineering GA DQ8XZ UT WOS:000379496300004 ER PT J AU Lazarus, N Meyer, CD AF Lazarus, N. Meyer, C. D. TI Stretchable inductor with liquid magnetic core SO MATERIALS RESEARCH EXPRESS LA English DT Article DE ferrofluid; stretchable electronics; inductors; liquid metal ID FERRO-NANOFLUID; ELECTRONICS; TRANSFORMERS; FLUID AB Adding magnetic materials is a well-established method for improving performance of inductors. However, traditional magnetic cores are rigid and poorly suited for the emerging field of stretchable electronics, where highly deformable inductors are used to wirelessly couple power and data signals. In this work, stretchable inductors are demonstrated based on the use of ferrofluids, magnetic liquids based on distributed magnetic particles, to create a compliant magnetic core. Using a silicone molding technique to create multi-layer fluidic channels, a liquid metal solenoid is fabricated around a ferrofluid channel. An analytical model is developed for the effects of mechanical strain, followed by experimental verification using two different ferrofluids with different permeabilities. Adding ferrofluid was found to increase the unstrained inductance by up to 280% relative to a similar inductor with a non-magnetic silicone core, while retaining the ability to survive uniaxial strains up to 100%. C1 [Lazarus, N.; Meyer, C. D.] US Army, Sensors & Electron Devices Directorate, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RP Lazarus, N (reprint author), US Army, Sensors & Electron Devices Directorate, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM nathan.lazarus2.civ@mail.mil NR 35 TC 0 Z9 0 U1 4 U2 5 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 2053-1591 J9 MATER RES EXPRESS JI Mater. Res. Express PD MAR PY 2016 VL 3 IS 3 AR 036103 DI 10.1088/2053-1591/3/3/036103 PG 10 WC Materials Science, Multidisciplinary SC Materials Science GA DO5GH UT WOS:000377811100032 ER PT J AU Finkel, P Moyet, RP Wun-Fogle, M Restorff, J Kosior, J Staruch, M Stace, J Amin, A AF Finkel, Peter Moyet, Richard Perez Wun-Fogle, Marilyn Restorff, James Kosior, Jesse Staruch, Margo Stace, Joseph Amin, Ahmed TI Non-Resonant Magnetoelectric Energy Harvesting Utilizing Phase Transformation in Relaxor Ferroelectric Single Crystals SO ACTUATORS LA English DT Article DE energy harvesting; magnetoelectric; inter-ferroelectric phase transformation; broadband; low frequency; multi-domain ID CONVERTER AB Recent advances in phase transition transduction enabled the design of a non-resonant broadband mechanical energy harvester that is capable of delivering an energy density per cycle up to two orders of magnitude larger than resonant cantilever piezoelectric type generators. This was achieved in a [011] oriented and poled domain engineered relaxor ferroelectric single crystal, mechanically biased to a state just below the ferroelectric rhombohedral (F-R)-ferroelectric orthorhombic (F-O) phase transformation. Therefore, a small variation in an input parameter, e.g., electrical, mechanical, or thermal will generate a large output due to the significant polarization change associated with the transition. This idea was extended in the present work to design a non-resonant, multi-domain magnetoelectric composite hybrid harvester comprised of highly magnetostrictive alloy, [Fe81.4Ga18.6 (Galfenol) or TbxDy1-xFe2 (Terfenol-D)], and lead indium niobate-lead magnesium niobate-lead titanate (PIN-PMN-PT) domain engineered relaxor ferroelectric single crystal. A small magnetic field applied to the coupled device causes the magnetostrictive element to expand, and the resulting stress forces the phase change in the relaxor ferroelectric single crystal. We have demonstrated high energy conversion in this magnetoelectric device by triggering the F-R-F-O transition in the single crystal by a small ac magnetic field in a broad frequency range that is important for multi-domain hybrid energy harvesting devices. C1 [Finkel, Peter; Staruch, Margo] US Navy, Res Lab, Mat Sci & Technol Div, Washington, DC 20375 USA. [Moyet, Richard Perez] Univ Connecticut, Dept Mat Sci & Engn, Storrs, CT 06269 USA. [Moyet, Richard Perez] Univ Connecticut, Inst Mat Sci, Storrs, CT 06269 USA. [Wun-Fogle, Marilyn; Restorff, James] US Army, Ctr Surface Warfare, Survivabil Struct & Mat Dept, Carderock Div, Bethesda, MD 20817 USA. [Kosior, Jesse] Rowan Univ, Dept Phys & Astron, Glassboro, NJ 08028 USA. [Stace, Joseph; Amin, Ahmed] US Navy, Undersea Warfare Ctr, Sensors & Sonar Syst Dept, Newport, RI 02841 USA. RP Finkel, P (reprint author), US Navy, Res Lab, Mat Sci & Technol Div, Washington, DC 20375 USA. EM peter.finkel@nrl.navy.mil; richard.perez_moyet@uconn.edu; marilyn.wun-fogle@navy.mil; james.restorff@navy.mil; kosior20@students.rowan.edu; margo.staruch@nrl.navy.mil; joseph.stace@navy.mil; ahmed.amin@navy.mil RI Staruch, Margo/M-9260-2015 OI Staruch, Margo/0000-0003-3088-2553 NR 17 TC 0 Z9 0 U1 11 U2 13 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 2076-0825 J9 ACTUATORS JI Actuators PD MAR PY 2016 VL 5 IS 1 AR 2 DI 10.3390/act5010002 PG 8 WC Instruments & Instrumentation SC Instruments & Instrumentation GA DO2KX UT WOS:000377609900002 ER PT J AU Lotufo, GR Belden, JB Fisher, JC Chen, SF Mowery, RA Chambliss, CK Rosen, G AF Lotufo, Guilherme R. Belden, Jason B. Fisher, Jonathon C. Chen, Shou-Feng Mowery, Richard A. Chambliss, C. Kevin Rosen, Gunther TI Accumulation and depuration of trinitrotoluene and related extractable and nonextractable (bound) residues in marine fish and mussels SO ENVIRONMENTAL POLLUTION LA English DT Article DE Trinitrotoluene; Bound residue; Nonextractable; Fish; Mussel ID CHROMATOGRAPHY-MASS-SPECTROMETRY; CATFISH ICTALURUS-PUNCTATUS; EARTHWORM EISENIA-ANDREI; COVALENT BINDING; MUNITIONS CONSTITUENTS; EXPLOSIVE COMPOUNDS; AQUATIC ORGANISMS; PROTEIN ADDUCTS; 2,4,6-TRINITROTOLUENE; TNT AB To determine if trinitrotoluene (TNT) forms nonextractable residues in mussels (Mytilus galloprovincialis) and fish (Cyprinodon variegatus) and to measure the relative degree of accumulation as compared to extractable TNT and its major metabolites, organisms were exposed to water fortified with C-14-TNT. After 24 h, nonextractable residues made up 75% (mussel) and 83% (fish) while TNT accounted for 2% of total radioactivity. Depuration half-lives for extractable TNT, aminodinitrotoluenes (ADNTs) and diaminonitrotoluenes (DANTs) were fast initially (<0.5 h), but slower for nonextractable residues. Nonextractable residues from organisms were identified as ADNTs and DANTs using 0.1 M HCL for solubilization followed by liquid chromatography-tandem mass spectrometry. Recovered metabolites only accounted for a small fraction of the bound residue quantified using a radiotracer likely because of low extraction or hydrolysis efficiency or alternative pathways of incorporation of radiolabel into tissue. Published by Elsevier Ltd. C1 [Lotufo, Guilherme R.] US Army Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. [Belden, Jason B.] Oklahoma State Univ, Dept Integrat Biol, Stillwater, OK 74078 USA. [Fisher, Jonathon C.] Northwestern State Univ, Dept Nat Sci, Tahlequah, OK 74464 USA. [Chen, Shou-Feng; Mowery, Richard A.; Chambliss, C. Kevin] Baylor Univ, Dept Chem, POB 97348, Waco, TX 76798 USA. [Rosen, Gunther] Space & Naval Warfare SPAWAR Syst Ctr Pacific, 53475 Strothe Rd, San Diego, CA 92152 USA. RP Lotufo, GR (reprint author), US Army Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM guilherme.lotufo@usace.army.mil NR 40 TC 0 Z9 0 U1 4 U2 6 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0269-7491 EI 1873-6424 J9 ENVIRON POLLUT JI Environ. Pollut. PD MAR PY 2016 VL 210 BP 129 EP 136 DI 10.1016/j.envpol.2015.11.049 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA DM9RO UT WOS:000376703600016 PM 26708767 ER PT J AU van Vuren, PJ Wiley, M Palacios, G Storm, N McCulloch, S Markotter, W Birkhead, M Kemp, A Paweska, JT AF van Vuren, Petrus Jansen Wiley, Michael Palacios, Gustavo Storm, Nadia McCulloch, Stewart Markotter, Wanda Birkhead, Monica Kemp, Alan Paweska, Janusz T. TI Isolation of a Novel Fusogenic Orthoreovirus from Eucampsipoda africana Bat Flies in South Africa SO VIRUSES-BASEL LA English DT Article DE bat flies; Reoviridae; Eucampsipoda africana; fusogenic orthoreovirus; Rousettus aegyptiacus; Nycteribiidae ID FRUIT BATS; VIRUS; REOVIRUS; RHABDOVIRUS; NYCTERIBIIDAE; INFECTIONS; RESERVOIRS; STREBLIDAE; SEQUENCES; DISEASE AB We report on the isolation of a novel fusogenic orthoreovirus from bat flies (Eucampsipoda africana) associated with Egyptian fruit bats (Rousettus aegyptiacus) collected in South Africa. Complete sequences of the ten dsRNA genome segments of the virus, tentatively named Mahlapitsi virus (MAHLV), were determined. Phylogenetic analysis places this virus into a distinct clade with Baboon orthoreovirus, Bush viper reovirus and the bat-associated Broome virus. All genome segments of MAHLV contain a 5' terminal sequence (5'-GGUCA) that is unique to all currently described viruses of the genus. The smallest genome segment is bicistronic encoding for a 14 kDa protein similar to p14 membrane fusion protein of Bush viper reovirus and an 18 kDa protein similar to p16 non-structural protein of Baboon orthoreovirus. This is the first report on isolation of an orthoreovirus from an arthropod host associated with bats, and phylogenetic and sequence data suggests that MAHLV constitutes a new species within the Orthoreovirus genus. C1 [van Vuren, Petrus Jansen; Storm, Nadia; Birkhead, Monica; Kemp, Alan; Paweska, Janusz T.] Natl Inst Communicable Dis, Ctr Emerging & Zoonot Dis, Natl Hlth Lab Serv, ZA-2131 Johannesburg, South Africa. [van Vuren, Petrus Jansen; Storm, Nadia; McCulloch, Stewart; Markotter, Wanda; Paweska, Janusz T.] Univ Pretoria, Fac Nat & Agr Sci, Dept Microbiol & Plant Pathol, ZA-0028 Pretoria, South Africa. [Wiley, Michael; Palacios, Gustavo] US Army, Med Res Inst Infect Dis, Ctr Genom Sci, Ft Detrick, MD 21702 USA. [Paweska, Janusz T.] Univ Witwatersrand, Fac Hlth Sci, ZA-2193 Johannesburg, South Africa. RP Paweska, JT (reprint author), Natl Inst Communicable Dis, Ctr Emerging & Zoonot Dis, Natl Hlth Lab Serv, ZA-2131 Johannesburg, South Africa.; Paweska, JT (reprint author), Univ Pretoria, Fac Nat & Agr Sci, Dept Microbiol & Plant Pathol, ZA-0028 Pretoria, South Africa.; Paweska, JT (reprint author), Univ Witwatersrand, Fac Hlth Sci, ZA-2193 Johannesburg, South Africa. EM petrusv@nicd.ac.za; michael.r.wiley19.ctr@mail.mil; gustavo.f.palacios.ctr@mail.mil; nadias@nicd.ac.za; Stewart.Mcculloch@up.ac.za; Wanda.Markotter@up.ac.za; monicab@nicd.ac.za; alank@nicd.ac.za; januszp@nicd.ac.za OI Markotter, Wanda/0000-0002-7550-0080; Palacios, Gustavo/0000-0001-5062-1938 FU CDC Global Disease Detection program [GDD 5U19 GH000571-05/96667]; South African National Research Foundation [91496, 92524]; Poliomyelitis Research Foundation, PRF [12/14]; South African National Research Foundation, Incentive Funding for Rated Researchers [85544]; NRF FX The project is jointly funded by the following grants awarded to: Janusz T. Paweska (CDC Global Disease Detection program, GDD 5U19 GH000571-05/96667), Wanda Markotter (South African National Research Foundation, Grant UID 91496 and 92524; Poliomyelitis Research Foundation, PRF Grant number 12/14) and Petrus Jansen van Vuren (South African National Research Foundation, Incentive Funding for Rated Researchers, Grant UID 85544).; The grant holders acknowledge that opinions, findings and conclusions or recommendations expressed in any publication generated by GDD and NRF-supported research are those of the authors and that the GDD and NRF accept no liability whatsoever in this regard. NR 46 TC 0 Z9 0 U1 0 U2 4 PU MDPI AG PI BASEL PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND SN 1999-4915 J9 VIRUSES-BASEL JI Viruses-Basel PD MAR PY 2016 VL 8 IS 3 AR 65 DI 10.3390/v8030065 PG 25 WC Virology SC Virology GA DI6HH UT WOS:000373599300009 ER PT J AU Sherlock, T AF Sherlock, Thomas TI Russian politics and the Soviet past: Reassessing Stalin and Stalinism under Vladimir Putin SO COMMUNIST AND POST-COMMUNIST STUDIES LA English DT Article DE Vladimir Putin; Russian nationalism; Russkii Mir; Eurasianism; Crimea; Donbas; Political identity; Soviet history; Memorialization; History textbooks; Stalinism; Stalin; Historical narratives; Grand narrative AB Evidence drawn from the intersection of historical memory and politics in Russia underline not only on-going framing battles over the Soviet past. The evidence suggests that the Kremlin is unwilling to develop and impose on society historical narratives which promote chauvinism, hypernationalism, and re-Stalinization. Although such an agenda has some support among incumbent elites and in society, it remains subordinate in terms of political influence as of early 2016. Instead, the regime is now extending support to groups in society and the political establishment which favor a critical assessment of the Soviet era, including Stalinism. This emerging criticism of the Soviet past serves a number of important goals of the leadership, including re-engagement with the West. To this end, the Kremlin recently approved new history textbooks critical of the Soviet past as well as a significant program that memorializes the victims of Soviet repressions. Yet the regime is unlikely to usher in thorough de-Stalinization which would threaten its power. Instead, the Kremlin is attempting to assemble a grand narrative that approves, as well as criticizes - in different measures - each of the regimes that existed in the 20th century (tsarist, communist, and post-communist). This incipient narrative constitutes a form of bricolage, which involves the retrieval and reassembly of diverse, often conflicting, elements to solve a problem. Here the problem is the long-standing, divisive issue of how to evaluate the history of 20th century Russia and its different regimes. The Kremlin now seeks to knit together the diverse identities of these regimes through the unifying historical thread of the Russian state. This act of bricolage also seeks to reconcile the contradictions within each regime: elements of the new narrative can be expected to condemn the inhumanity of Stalin and Stalinism while other facets will extol industrialization and the Great Patriotic War as the achievements of Russian-led Soviet society. From this perspective, neither re-Stalinization nor de-Stalinization is likely to occur in Putin's Russia. Nevertheless, if recent initiatives remain in place, critical assessments of Soviet foreign and domestic policies will become increasingly commonplace. (C) 2016 Published by Elsevier Ltd on behalf of The Regents of the University of California. C1 [Sherlock, Thomas] US Mil Acad, Dept Social Sci, West Point, NY USA. RP Sherlock, T (reprint author), US Mil Acad, Dept Social Sci, West Point, NY USA. NR 62 TC 0 Z9 0 U1 4 U2 5 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0967-067X EI 1873-6920 J9 COMMUNIS POST-COMMUN JI Communist Post-Communist Stud. PD MAR PY 2016 VL 49 IS 1 SI SI BP 45 EP 59 DI 10.1016/j.postcomstud.2016.01.001 PG 15 WC International Relations; Political Science SC International Relations; Government & Law GA DK0JJ UT WOS:000374598800005 ER PT J AU Ibrahim, SH Hirsova, P Tomita, K Bronk, SF Werneburg, NW Harrison, SA Goodfellow, VS Malhi, H Gores, GJ AF Ibrahim, Samar H. Hirsova, Petra Tomita, Kyoko Bronk, Steven F. Werneburg, Nathan W. Harrison, Stephen A. Goodfellow, Val S. Malhi, Harmeet Gores, Gregory J. TI Mixed Lineage Kinase 3 Mediates Release of C-X-C Motif Ligand 10-Bearing Chemotactic Extracellular Vesicles From Lipotoxic Hepatocytes SO HEPATOLOGY LA English DT Article ID FATTY LIVER-DISEASE; P38 MAP KINASE; NONALCOHOLIC STEATOHEPATITIS; PATHOGENESIS; ACTIVATION; APOPTOSIS; PROTEIN; CXCL10; CELLS; LYSOPHOSPHATIDYLCHOLINE AB Mixed lineage kinase 3 (MLK3) deficiency reducesmacrophage-associated inflammation in a murine model of nonalcoholic steatohepatitis (NASH). However, the mechanistic links between MLK3 activation in hepatocytes and macrophage-driven inflammation in NASH are uncharted. Herein, we report that MLK3 mediates the release of (C-X-C motif) ligand 10 (CXCL10)-laden extracellular vesicles (EVs) from lipotoxic hepatocytes, which induce macrophage chemotaxis. Primary mouse hepatocytes (PMHs) and Huh7 cells were treated with palmitate or lysophosphatidylcholine (LPC). Released EVs were isolated by differential ultracentrifugation. LPC treatment of PMH or Huh7 cells induced release of EVs, which was prevented by either genetic or pharmacological inhibition of MLK3. Mass spectrometry identified the potent chemokine, CXCL10, in the EVs, which was markedly enriched in EVs isolated from LPC-treated hepatocytes versus untreated cells. Green fluorescent protein (GFP)-tagged CXCL10 was present in vesicular structures and colocalized with the red fluorescent protein (RFP)-tagged EV marker, CD63, after LPC treatment of cotransfected Huh-7 cells. Either genetic deletion or pharmacological inhibition of MLK3 prevented CXCL10 enrichment in EVs. Treatment of mouse bonemarrow-derived macrophages with lipotoxic hepatocyte-derived EVs induced macrophage chemotaxis, an effect blocked by incubation with CXCL10-neutralizing antisera. MLK3-deficientmice fed a NASH-inducing diet had reduced concentrations of total plasma EVs and CXCL10 containing EVs compared to wild-type mice. Conclusions: During hepatocyte lipotoxicity, activated MLK3 induces the release ofCXCL10-bearing vesicles from hepatocytes, which are chemotactic for macrophages. C1 [Ibrahim, Samar H.] Mayo Clin, Div Pediat Gastroenterol, Rochester, MN 55905 USA. [Hirsova, Petra; Tomita, Kyoko; Bronk, Steven F.; Werneburg, Nathan W.; Malhi, Harmeet; Gores, Gregory J.] Mayo Clin, Div Gastroenterol & Hepatol, Rochester, MN 55905 USA. [Harrison, Stephen A.] Brooke Army Med Ctr, Houston, TX USA. [Goodfellow, Val S.] Califia Bio Inc, San Diego, CA USA. RP Gores, GJ (reprint author), Mayo Clin, Med & Physiol, 200 First St SW, Rochester, MN 55905 USA. EM gores.gregory@mayo.edu FU Center for Clinical and Translational Science (CCaTS), KL2 program [KL2TR000136-09]; Pilot and Feasibility Award; Mayo Clinic Center for Cell Signaling in Gastroenterology [P30DK084567]; National Institutes of Health (NIH) [DK97178]; NIH [DK41876]; Mayo Clinic (Rochester, MN) FX This work was supported by the Center for Clinical and Translational Science (CCaTS), KL2 program KL2TR000136-09 (to S.H.I.), a Pilot and Feasibility Award (to S.H.I.), and the optical microscopy core of the Mayo Clinic Center for Cell Signaling in Gastroenterology (P30DK084567), National Institutes of Health (NIH) DK97178 (to H.M.), NIH grant DK41876 (to G.J.G.), and the Mayo Clinic (Rochester, MN). NR 40 TC 7 Z9 7 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0270-9139 EI 1527-3350 J9 HEPATOLOGY JI Hepatology PD MAR PY 2016 VL 63 IS 3 BP 731 EP 744 DI 10.1002/hep.28252 PG 14 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA DJ8WF UT WOS:000374493200011 PM 26406121 ER PT J AU Scribner, DR AF Scribner, David R. TI Predictors of Shoot-Don't Shoot Decision-Making Performance: An Examination of Cognitive and Emotional Factors SO JOURNAL OF COGNITIVE ENGINEERING AND DECISION MAKING LA English DT Article DE marksmanship; soldier performance; decision making; workload; fratricide; individual factors; emotional factors; working memory capacity ID WORKING-MEMORY CAPACITY; INDIVIDUAL-DIFFERENCES; EXECUTIVE ATTENTION; FLUID INTELLIGENCE; SELF-REGULATION; ANXIETY; STRESS AB Soldiers are required to perform basic combat tasks, such as move, shoot, and communicate, and to make decisions under many environmental stressors, including continuous operations and information-processing tasks driven by C4ISR (Command, Control, Communications, Computers, Intelligence, Surveillance, and Reconnaissance) and other types of information systems. Knowledge requires information processing, and increased processing is usually the root cause of increased error. Friend-or-foe decision-making research has primarily focused on the types of equipment being used and task difficulty levels to examine shoot-don't shoot errors; however, newer theoretical approaches may enhance cognitive performance research and models focused on decision-making performance. Higher explanatory power and better prediction models may be created using multitheoretical individual factors derived from transactional-stress and information-processing theories. The purpose of this study was to examine multitheoretical individual factor effects of emotional and cognitive predictor variables under dual-task simulated shoot-don't shoot target scenarios. A quantitative repeated-measures approach was used with a convenience sample of 12 U.S. Army soldiers ages 18 to 34 years. C1 [Scribner, David R.] US Army, Res Lab, Aberdeen, MD USA. RP Scribner, DR (reprint author), US Army, Res Lab, Human Res & Engn Direcorate, 459 Mulberry Rd, Aberdeen Proving Ground, MD 21005 USA. EM david.r.scribner.civ@mail.mil NR 47 TC 2 Z9 2 U1 3 U2 5 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1555-3434 EI 2169-5032 J9 J Cogn Eng Decis Mak JI J. Cogn. Eng. Decis. Mak. PD MAR PY 2016 VL 10 IS 1 BP 3 EP 13 DI 10.1177/1555343415608974 PG 11 WC Psychology, Experimental SC Psychology GA DK1GT UT WOS:000374661200001 ER PT J AU Gailani, JZ Lackey, TC King, DB Bryant, D Kim, SC Shafer, DJ AF Gailani, Joseph Z. Lackey, Tahirih C. King, David B., Jr. Bryant, Duncan Kim, Sung-Chan Shafer, Deborah J. TI Predicting dredging-associated effects to coral reefs in Apra Harbor, Guam - Part 1: Sediment exposure modeling SO JOURNAL OF ENVIRONMENTAL MANAGEMENT LA English DT Article DE Dredging; Exposure; Coral; Computer modeling; Deposition; Sedimentation rate; Suspended sediment concentration ID NEW-CALEDONIA; TRANSPORT; LAGOON; BAY AB Model studies were conducted to investigate the potential coral reef sediment exposure from dredging associated with proposed development of a deepwater wharf in Apra Harbor, Guam. The Particle Tracking Model (PTM) was applied to quantify the exposure of coral reefs to material suspended by the dredging operations at two alternative sites. Key PTM features include the flexible capability of continuous multiple releases of sediment parcels, control of parcel/substrate interaction, and the ability to efficiently track vast numbers of parcels. This flexibility has facilitated simulating the combined effects of sediment released from clamshell dredging and chiseling within Apra Harbor. Because the rate of material released into the water column by some of the processes is not well understood or known a priori, the modeling approach was to bracket parameters within reasonable ranges to produce a suite of potential results from multiple model runs. Sensitivity analysis to model parameters is used to select the appropriate parameter values for bracketing. Data analysis results include mapping the time series and the maximum values of sedimentation, suspended sediment concentration, and deposition rate. Data were used to quantify various exposure processes that affect coral species in Apra Harbor. The goal of this research is to develop a robust methodology for quantifying and bracketing exposure mechanisms to coral (or other receptors) from dredging operations. These exposure values were utilized in an ecological assessment to predict effects (coral reef impacts) from various dredging scenarios. (C) 2015 Published by Elsevier Ltd. C1 [Gailani, Joseph Z.; Lackey, Tahirih C.; King, David B., Jr.; Bryant, Duncan; Kim, Sung-Chan; Shafer, Deborah J.] US Army Corps Engineers, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. [Shafer, Deborah J.] 6544 Crowfoot Rd, Trail, OR 97541 USA. RP Gailani, JZ (reprint author), US Army Corps Engineers, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM joe.Z.Gailani@usace.army.mil; DrDeborahShafer@gmail.com FU Naval Facility Engineering Command; US Army Corps of Engineers Dredging Operations and Environmental Research Program; Dredging Operations and Technical Support Program FX Partial funding for this study was provided by Naval Facility Engineering Command. Additional funding was provided by the US Army Corps of Engineers Dredging Operations and Environmental Research Program, and the Dredging Operations and Technical Support Program. Naval Facility Engineering Command was not involved in the data collection, analysis and interpretation or writing of this manuscript. Approval to publish this manuscript has been granted by Naval Facility Engineering Command. NR 26 TC 1 Z9 1 U1 2 U2 8 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0301-4797 EI 1095-8630 J9 J ENVIRON MANAGE JI J. Environ. Manage. PD MAR 1 PY 2016 VL 168 BP 16 EP 26 DI 10.1016/j.jenvman.2015.10.027 PG 11 WC Environmental Sciences SC Environmental Sciences & Ecology GA DL6EJ UT WOS:000375732100003 PM 26692413 ER PT J AU Nelson, DS McManus, J Richmond, RH King, DB Gailani, JZ Lackey, TC Bryant, D AF Nelson, Deborah Shafer McManus, John Richmond, Robert H. King, David B., Jr. Gailani, Joe Z. Lackey, Tahirih C. Bryant, Duncan TI Predicting dredging-associated effects to coral reefs in Apra Harbor, Guam - Part 2: Potential coral effects SO JOURNAL OF ENVIRONMENTAL MANAGEMENT LA English DT Article DE Dredging; Turbidity; Sedimentation rate; Deposition; Coral threshold responses; Stoplight indicators ID SEDIMENTATION; ORGANISMS; POLLUTION AB Coral reefs are in decline worldwide due to anthropogenic stressors including reductions in water and substratum quality. Dredging results in the mobilization of sediments, which can stress and kill corals via increasing turbidity, tissue damage and burial. The Particle Tracking Model (PTM) was applied to predict the potential impacts of dredging-associated sediment exposure on the coral reef ecosystems of Apra Harbor, Guam. The data were interpreted using maps of bathymetry and coral abundance and distribution in conjunction with impact parameters of suspended sediment concentration (turbidity) and sedimentation using defined coral response thresholds. The results are presented using a "stoplight" model of negligible or limited impacts to coral reefs (green), moderate stress from which some corals would be expected to recover while others would not (yellow) and severe stress resulting in mortality (red). The red conditions for sediment deposition rate and suspended sediment concentration (SSC) were defined as values exceeding 25 mg cm(-2) d(-1) over any 30 day window and >20 mg/l for any 18 days in any 90 day period over a column of water greater than 2 m, respectively. The yellow conditions were defined as values >10 mg cm(-2) d(-1) and <25 mg cm(-2) d(-1) over any 30 day period, and as 20% of 3 months' concentration exceeding 10 mg/l for the deposition and SSC, respectively. The model also incorporates the potential for cumulative effects on the assumption that even sub-lethal stress levels can ultimately lead to mortality in a multi-stressor system. This modeling approach can be applied by resource managers and regulatory agencies to support management decisions related to planning, site selection, damage reduction, and compensatory mitigation. Published by Elsevier Ltd. C1 [Nelson, Deborah Shafer; King, David B., Jr.; Gailani, Joe Z.; Lackey, Tahirih C.; Bryant, Duncan] US Army Corps Engineers, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS USA. [McManus, John] Univ Miami, 4600 Rickenbacker Causeway, Miami, FL USA. [Richmond, Robert H.] Univ Hawaii Manoa, Kewalo Marine Lab, 41 Ahui St, Honolulu, HI 96822 USA. RP Nelson, DS (reprint author), US Army Corps Engineers, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS USA. EM DrDeborahShafer@gmail.com FU Naval Facility Engineering Command; US Army Corps of Engineers Dredging Operations and Environmental Research Program; Dredging Operations and Technical Support Programs FX Partial funding for this study was provided by Naval Facility Engineering Command. Additional funding was provided by the US Army Corps of Engineers Dredging Operations and Environmental Research Program, and the Dredging Operations and Technical Support Programs. Naval Facility Engineering Command was not involved in the data collection, analysis and interpretation or writing of this manuscript. Approval to publish this manuscript has been granted by Naval Facility Engineering Command. NR 29 TC 2 Z9 2 U1 2 U2 5 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0301-4797 EI 1095-8630 J9 J ENVIRON MANAGE JI J. Environ. Manage. PD MAR 1 PY 2016 VL 168 BP 111 EP 122 DI 10.1016/j.jenvman.2015.10.025 PG 12 WC Environmental Sciences SC Environmental Sciences & Ecology GA DL6EJ UT WOS:000375732100013 PM 26704453 ER PT J AU Jacobs, K Tezak, N Mabuchi, H Balu, R AF Jacobs, Kurt Tezak, Nikolas Mabuchi, Hideo Balu, Radhakrishnan TI All-mechanical quantum noise cancellation for accelerometry: broadband with momentum measurements, narrow band without SO JOURNAL OF OPTICS LA English DT Article DE quantum metrology; optomechanics; force sensing; acelerometry; quantum nanoelectromechanics; continuous measurement ID RADIATION-PRESSURE; SQUEEZED STATES; OSCILLATOR AB We show that the ability to make direct measurements of momentum, in addition to the usual direct measurements of position, allows a simple configuration of two identical mechanical oscillators to be used for broadband back-action-free force metrology. This would eliminate the need for an optical reference oscillator in the scheme of Tsang and Caves (2010 Phys. Rev. Lett.. 105 123601), along with its associated disadvantages. We also show that if one is restricted to position measurements alone then two copies of the same two-oscillator configuration can be used for narrow-band back-action-free force metrology. C1 [Jacobs, Kurt; Balu, Radhakrishnan] US Army Res Lab, Computat & Informat Sci Directorate, Adelphi, MD 20783 USA. [Jacobs, Kurt] Univ Massachusetts, Dept Phys, Boston, MA 02125 USA. [Jacobs, Kurt] Louisiana State Univ, Hearne Inst Theoret Phys, Baton Rouge, LA 70803 USA. [Tezak, Nikolas; Mabuchi, Hideo] Stanford Univ, Edward L Ginzton Lab, Stanford, CA 94305 USA. RP Jacobs, K (reprint author), US Army Res Lab, Computat & Informat Sci Directorate, Adelphi, MD 20783 USA.; Jacobs, K (reprint author), Univ Massachusetts, Dept Phys, Boston, MA 02125 USA.; Jacobs, K (reprint author), Louisiana State Univ, Hearne Inst Theoret Phys, Baton Rouge, LA 70803 USA. EM kurt.jacobs@umb.edu NR 29 TC 0 Z9 0 U1 2 U2 4 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 2040-8978 EI 2040-8986 J9 J OPTICS-UK JI J. Opt. PD MAR PY 2016 VL 18 IS 3 AR 034002 DI 10.1088/2040-8978/18/3/034002 PG 8 WC Optics SC Optics GA DL6LF UT WOS:000375750000004 ER PT J AU Andrews, ES Turell, MJ AF Andrews, Elizabeth S. Turell, Michael J. TI EFFECT OF HOLDING CONDITIONS ON THE DETECTION OF CHIKUNGUNYA AND VENEZUELAN EQUINE ENCEPHALITIS VIRUSES IN MOSQUITO POOLS SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article DE Arbovirus; reverse transcriptase-quantitative polymerase chain reaction; stability; temperature ID POLYMERASE-CHAIN-REACTION; AEDES-AEGYPTI DIPTERA; VIRAL-RNA; JAPANESE ENCEPHALITIS; PERSISTENCE; AUSTRALIA; STORAGE AB Emerging and re-emerging arboviruses continue to be a threat to global public health, and viral surveillance of mosquito populations is critical for mosquito control operations. Due to the tropical climate of many of the affected areas, it may be difficult to maintain a cold chain as the samples travel from collection sites to laboratories for testing. We determined how suboptimal holding temperatures affected the ability to detect viruses in pools of mosquitoes. Adult female Aedes albopictus and Ae. taeniorhynchus individuals were inoculated with chikungunya virus or Venezuelan equine encephalitis virus suspensions, respectively, and placed at 26 degrees C for 8 days. One infected mosquito was then added to a vial of 24 negative mosquitoes and held at -80 degrees C, -20 degrees C, 4 degrees C, 22 degrees C, or 35 degrees C for up to 14 days. Mosquito pools were analyzed for both infectious virus by plaque assay and for viral ribonucleic acid (RNA) with reverse transcriptase quantitative polymerase chain reaction (RT-qPCR). At higher temperatures, the amount of infectious virus decreased rapidly, but viruses in samples held at 4 degrees C or lower remained relatively stable. In contrast, viral RNA was detectable from pools held at all temperatures and holding times by RT-qPCR. Cycle threshold (Ct) values increased as temperatures and holding times increased. These findings suggest that if viral RNA detection is the goal of surveillance efforts, then mosquito pools do not require storage at 4 degrees C. This enhances the feasibility of field-based arbovirus surveillance programs in which maintaining a cold chain may not be a possibility. C1 [Andrews, Elizabeth S.; Turell, Michael J.] US Army, Med Res Inst Infect Dis, Div Virol, 1425 Porter St, Ft Detrick, MD 21702 USA. RP Andrews, ES (reprint author), US Army, Med Res Inst Infect Dis, Div Virol, 1425 Porter St, Ft Detrick, MD 21702 USA. NR 15 TC 0 Z9 0 U1 0 U2 0 PU AMER MOSQUITO CONTROL ASSOC PI MOUNT LAUREL PA 15000 COMMERCE PARKWAY, SUITE C, MOUNT LAUREL, NJ 08054 USA SN 8756-971X EI 1943-6270 J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD MAR PY 2016 VL 32 IS 1 BP 51 EP 54 PG 4 WC Entomology SC Entomology GA DJ9CA UT WOS:000374510400006 PM 27105216 ER PT J AU Jahnke, JP Cornejo, JA Sumner, JJ Schuler, AJ Atanassov, P Ista, LK AF Jahnke, Justin P. Cornejo, Jose A. Sumner, James J. Schuler, Andrew J. Atanassov, Plamen Ista, Linnea K. TI Conjugated gold nanoparticles as a tool for probing the bacterial cell envelope: The case of Shewanella oneidensis MR-1 SO BIOINTERPHASES LA English DT Article ID SELF-ASSEMBLED MONOLAYERS; OLIGO(ETHYLENE GLYCOL); SURFACE-PROPERTIES; ESCHERICHIA-COLI; OUTER-MEMBRANE; ATTACHMENT; BIOFILMS; ADHESION; PROTEINS; RESISTANCE AB The bacterial cell envelope forms the interface between the interior of the cell and the outer world and is, thus, the means of communication with the environment. In particular, the outer cell surface mediates the adhesion of bacteria to the surface, the first step in biofilm formation. While a number of ligand-based interactions are known for the attachment process in commensal organisms and, as a result, opportunistic pathogens, the process of nonspecific attachment is thought to be mediated by colloidal, physiochemical, interactions. It is becoming clear, however, that colloidal models ignore the heterogeneity of the bacterial surface, and that the so-called nonspecific attachment may be mediated by specific regions of the cell surface, whether or not the relevant interaction is ligand-mediate. The authors introduce surface functionalized gold nanoparticles to probe the surface chemistry of Shewanella oneidensis MR-1 as it relates to surface attachment to x-substituted alkanethiolates self-assembled monolayers (SAMs). A linear relationship between the attachment of S. oneidensis to SAM modified planar substrates and the number of similarly modified nanoparticles attached to the bacterial surfaces was demonstrated. In addition, the authors demonstrate that carboxylic acid-terminated nanoparticles attach preferentially to the subpolar region of the S. oneidensis and obliteration of that binding preference corresponds in loss of attachment to carboxylic acid terminated SAMs. Moreover, this region corresponds to suspected functional regions of the S. oneidensis surface. Because this method can be employed over large numbers of cells, this method is expected to be generally applicable for understanding cell surface organization across populations. (C) 2016 Author(s). C1 [Jahnke, Justin P.; Sumner, James J.] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. [Cornejo, Jose A.; Atanassov, Plamen; Ista, Linnea K.] Univ New Mexico, Ctr Biomed Engn, Ctr Microengn Mat, Dept Biol Engn, Albuquerque, NM 87131 USA. [Schuler, Andrew J.] Univ New Mexico, Dept Civil Engn, Albuquerque, NM 87131 USA. RP Ista, LK (reprint author), Univ New Mexico, Ctr Biomed Engn, Ctr Microengn Mat, Dept Biol Engn, Albuquerque, NM 87131 USA. EM lkista@unm.edu FU Army Research Office [W911NF1210208]; Defense Threat Reduction Agency [HDTRA-1-11-1-0004]; U.S. Army Research Laboratory Postdoctoral Fellowship Program FX Shewanella oneidensis MR-1 and mutant strains used in this work was the kind gift of M. Y. Naggar at USC. The authors thank Christian J. Sund of the U.S. Army Research Laboratory for helpful discussions. This work was supported by grants from the Army Research Office (Grant No. W911NF1210208) and the Defense Threat Reduction Agency (Grant No. HDTRA-1-11-1-0004). J.P.J. acknowledges support from the U.S. Army Research Laboratory Postdoctoral Fellowship Program administered by the Oak Ridge Associated Universities. NR 51 TC 0 Z9 0 U1 6 U2 15 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 1934-8630 EI 1559-4106 J9 BIOINTERPHASES JI Biointerphases PD MAR PY 2016 VL 11 IS 1 AR 011003 DI 10.1116/1.4939244 PG 7 WC Biophysics; Materials Science, Biomaterials SC Biophysics; Materials Science GA DK5TB UT WOS:000374982200003 PM 26746161 ER PT J AU Diefenderfer, HL Johnson, GE Thom, RM Buenau, KE Weitkamp, LA Woodley, CM Borde, AB Kropp, RK AF Diefenderfer, Heida L. Johnson, Gary E. Thom, Ronald M. Buenau, Kate E. Weitkamp, Laurie A. Woodley, Christa M. Borde, Amy B. Kropp, Roy K. TI Evidence-based evaluation of the cumulative effects of ecosystem restoration SO ECOSPHERE LA English DT Article DE causal criteria; critical thinking; cumulative effects; evidence-based medicine; fisheries; floodplain food web; habitat connectivity; hydropower mitigation; large-scale ecosystem restoration; salmon recovery; sustainability science; systematic review; tidal wetlands ID JUVENILE CHINOOK SALMON; LOWER COLUMBIA RIVER; RESTORED ESTUARINE WETLAND; DIEL FEEDING CHRONOLOGY; ONCORHYNCHUS-KISUTCH; COHO SALMON; FOOD WEBS; SEASONAL FLOODPLAIN; ADAPTIVE MANAGEMENT; GASTRIC EVACUATION AB This study adapts and applies the evidence-based approach for causal inference, a medical standard, to the restoration and sustainable management of large-scale aquatic ecosystems. Despite long-term investments in restoring aquatic ecosystems, it has proven difficult to adequately synthesize and evaluate program outcomes, and no standard method has been adopted. Complex linkages between restorative actions and ecosystem responses at a landscape scale make evaluations problematic and most programs focus on monitoring and analysis. Herein, we demonstrate a new transdisciplinary approach integrating techniques from evidence-based medicine, critical thinking, and cumulative effects assessment. Tiered hypotheses about the effects of landscape-scale restorative actions are identified using an ecosystem conceptual model. The systematic literature review, a health sciences standard since the 1960s, becomes just one of seven lines of evidence assessed collectively, using critical thinking strategies, causal criteria, and cumulative effects categories. As a demonstration, we analyzed data from 166 locations on the Columbia River and estuary representing 12 indicators of habitat and fish response to floodplain restoration actions intended to benefit culturally and economically important, threatened and endangered salmon. Synthesis of the lines of evidence demonstrated that hydrologic reconnection promoted macrodetritis export, prey availability, and juvenile fish access and feeding. Upon evaluation, the evidence was sufficient to infer cross-boundary, indirect, compounding, and delayed cumulative effects, and suggestive of nonlinear, landscape-scale, and spatial density effects. Therefore, on the basis of causal inferences regarding food-web functions, we concluded that the restoration program is having a cumulative beneficial effect on juvenile salmon. The lines of evidence developed are transferable to other ecosystems: modeling of cumulative net ecosystem improvement, physical modeling of ecosystem controlling factors, meta-analysis of restoration action effectiveness, analysis of data on target species, research on critical ecological uncertainties, evidence-based review of the literature, and change analysis on the landscape setting. As with medicine, the science of ecological restoration needs scientific approaches to management decisions, particularly because the consequences affect species extinctions and the availability of ecosystem services. This evidence-based approach will enable restoration in complex coastal, riverine, and tidal-fluvial ecosystems like the lower Columbia River to be evaluated when data have accumulated without sufficient synthesis. C1 [Diefenderfer, Heida L.; Johnson, Gary E.; Thom, Ronald M.; Buenau, Kate E.; Woodley, Christa M.; Borde, Amy B.; Kropp, Roy K.] Pacific NW Natl Lab, Marine Sci Lab, 1529 West Sequim Bay Rd, Sequim, WA 98382 USA. [Weitkamp, Laurie A.] NOAA, NW Fisheries Sci Ctr, Newport, OR 97365 USA. [Woodley, Christa M.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Diefenderfer, HL (reprint author), Pacific NW Natl Lab, Marine Sci Lab, 1529 West Sequim Bay Rd, Sequim, WA 98382 USA. EM heida.diefenderfer@pnnl.gov OI Buenau, Kate/0000-0003-2156-7260 FU U.S. Army Corps of Engineers, Portland District; NOAA Fisheries; Northwest Fisheries Science Center; U.S. Army Corps of Engineers, Walla Walla District FX We appreciate the financial support of the U.S. Army Corps of Engineers, Portland District. We are grateful to biologists B Ebberts, C Studebaker, and C Roegner for their leadership. Data collection by L Weitkamp was funded by the NOAA Fisheries, Northwest Fisheries Science Center and collection by C Woodley was funded by U.S. Army Corps of Engineers, Portland District and Walla Walla District. We thank A Cameron, A Coleman, V Cullinan, E Dawley, B Ebberts, M Hudson, J Johnson, L Johnson, K MacNeale, K Marcoe, R McNatt, D Putman, M Russell, N Sather, J Skalski, K Sobocinski, and A Uber for their contributions and others for help in the field and laboratory. HLD thanks B. Brehm, D. Qualley, and P. Steinberger for guidance on critical reasoning and judgment. NR 136 TC 3 Z9 3 U1 25 U2 50 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2150-8925 J9 ECOSPHERE JI Ecosphere PD MAR PY 2016 VL 7 IS 3 AR e01242 DI 10.1002/ecs2.1242 PG 33 WC Ecology SC Environmental Sciences & Ecology GA DK4OB UT WOS:000374896800014 ER PT J AU Welton, MD AF Welton, Mark D. TI Doubt in Islamic Law: A History of Legal Maxims, Interpretation, and Islamic Criminal Law SO MIDDLE EAST JOURNAL LA English DT Book Review C1 [Welton, Mark D.] US Mil Acad, West Point, NY 10996 USA. RP Welton, MD (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU MIDDLE EAST INST PI WASHINGTON PA 1761 N ST NW, CIRCULATION DEPT, WASHINGTON, DC 20036-2882 USA SN 0026-3141 EI 1940-3461 J9 MIDDLE EAST J JI Middle East J. PD SPR PY 2016 VL 70 IS 2 BP 343 EP 344 PG 2 WC Area Studies SC Area Studies GA DK9FQ UT WOS:000375236600017 ER PT J AU Fegyveresi, JM Alley, RB Fitzpatrick, JJ Cuffey, KM McConnell, JR Voigt, DE Spencer, MK Stevens, NT AF Fegyveresi, John M. Alley, Richard B. Fitzpatrick, Joan J. Cuffey, Kurt M. McConnell, Joseph R. Voigt, Donald E. Spencer, Matthew K. Stevens, Nathan T. TI Five millennia of surface temperatures and ice core bubble characteristics from the WAIS Divide deep core, West Antarctica SO PALEOCEANOGRAPHY LA English DT Article DE ice cores; bubble number density; ice core bubbles; holocene climate; paleoclimate reconstruction; bubble characteristics ID LOCALLY WEIGHTED REGRESSION; AIR BUBBLES; PHYSICAL-PROPERTIES; SHEET SURFACE; MELT LAYERS; SIPLE DOME; POLAR ICE; FIRN; NUMBER; DENSIFICATION AB Bubble number densities from the West Antarctic Ice Sheet (WAIS) Divide deep core in West Antarctica record relatively stable temperatures during the middle Holocene followed by late Holocene cooling. We measured bubble number density, shape, size, and arrangement on new samples of the main WAIS Divide deep core WDC06A from similar to 580m to similar to 1600 depth. The bubble size, shape, and arrangement data confirm that the samples satisfy the requirements for temperature reconstructions. A small correction for cracks formed after core recovery allows extension of earlier work through the brittle ice zone, and a site-specific calibration reduces uncertainties. Using an independently constructed accumulation rate history and a steady state bubble number density model, we determined a temperature reconstruction that agrees closely with other independent estimates, showing a stable middle Holocene, followed by a cooling of similar to 1.25 degrees C in the late Holocene. Over the last similar to 5 millennia, accumulation has been higher during warmer times by similar to 12%degrees C-1, somewhat stronger than for thermodynamic control alone, suggesting dynamic processes. C1 [Fegyveresi, John M.; Alley, Richard B.; Voigt, Donald E.; Stevens, Nathan T.] Penn State Univ, Dept Geosci, University Pk, PA 16802 USA. [Fegyveresi, John M.; Alley, Richard B.; Voigt, Donald E.; Stevens, Nathan T.] Penn State Univ, Earth & Environm Syst Inst, University Pk, PA 16802 USA. [Fegyveresi, John M.] Cold Reg Res & Engn Lab, Terr & Cryospher Sci Branch, Hanover, NH USA. [Fitzpatrick, Joan J.] US Geol Survey, Geosci & Environm Change Sci Ctr, Box 25046, Denver, CO 80225 USA. [Cuffey, Kurt M.] Univ Calif Berkeley, Dept Earth & Planetary Sci, Berkeley, CA 94720 USA. [McConnell, Joseph R.] Univ Nevada, Desert Res Inst, Div Hydrol Sci, Reno, NV 89506 USA. [Spencer, Matthew K.] Lake Super State Univ, Sch Phys Sci, Sault Ste Marie, ON, Canada. RP Fegyveresi, JM (reprint author), Penn State Univ, Dept Geosci, University Pk, PA 16802 USA.; Fegyveresi, JM (reprint author), Penn State Univ, Earth & Environm Syst Inst, University Pk, PA 16802 USA.; Fegyveresi, JM (reprint author), Cold Reg Res & Engn Lab, Terr & Cryospher Sci Branch, Hanover, NH USA. EM john.m.fegyveresi@usace.army.mil FU U.S. Geological Survey Climate and Land Use Change Research and Development Program; U.S. National Science Foundation Division of Polar Programs [0539578, 1043528, 1043313, 0539232, 0537661, 0839093, 1142166] FX We acknowledge the following funding sources for support of this work: U.S. Geological Survey Climate and Land Use Change Research and Development Program, and the U.S. National Science Foundation Division of Polar Programs grants 0539578, 1043528, 1043313, 0539232, 0537661, 0839093, and 1142166. We also acknowledge the staff of the U.S. National Ice Core Laboratory in Denver, Colorado, E. Cravens, the WAIS Divide Science Coordination Office at the University of New Hampshire, and the Ice Drilling Design and Operations group at the University of Wisconsin, whose phenomenal success in designing and operating the new Deep Ice Sheet Coring (DISC) drill has reinvigorated U.S. deep ice coring efforts. We thank numerous colleagues in the WAIS Divide project, especially C. Buizert, G. Clow, and E. Steig. We also acknowledge L. Layman, O. Maselli, D. Pasteris, and M. Sigl at the Desert Research Institute of Reno, Nevada, for their assistance with chemical analyses of ice samples. Lastly, we thank our three reviewers, whose thoughtful suggestions and questions served to clarify and improve this manuscript. Data policy: All data presented here are available via download from NSIDC (http://nsidc.org) or from the WAIS Divide data portal (http://waisdivide.unh.edu). NR 58 TC 1 Z9 1 U1 6 U2 6 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0883-8305 EI 1944-9186 J9 PALEOCEANOGRAPHY JI Paleoceanography PD MAR PY 2016 VL 31 IS 3 BP 416 EP 433 DI 10.1002/2015PA002851 PG 18 WC Geosciences, Multidisciplinary; Oceanography; Paleontology SC Geology; Oceanography; Paleontology GA DJ6SU UT WOS:000374344000005 ER PT J AU Clark, MP Schaefli, B Schymanski, SJ Samaniego, L Luce, CH Jackson, BM Freer, JE Arnold, JR Moore, RD Istanbulluoglu, E Ceola, S AF Clark, Martyn P. Schaefli, Bettina Schymanski, Stanislaus J. Samaniego, Luis Luce, Charles H. Jackson, Bethanna M. Freer, Jim E. Arnold, Jeffrey R. Moore, R. Dan Istanbulluoglu, Erkan Ceola, Serena TI Improving the theoretical underpinnings of process-based hydrologic models SO WATER RESOURCES RESEARCH LA English DT Editorial Material DE hydrologic theory; multiple hypotheses; model evaluation; uncertainty ID DYNAMIC TOPMODEL; WATERSHED THERMODYNAMICS; ALTERNATIVE BLUEPRINT; ENVIRONMENTAL-MODELS; UNIFYING FRAMEWORK; FORESTED CATCHMENT; STORAGE DYNAMICS; RUNOFF PROCESSES; MULTIPLE SCALES; STATE VARIABLES AB In this Commentary, we argue that it is possible to improve the physical realism of hydrologic models by making better use of existing hydrologic theory. We address the following questions: (1) what are some key elements of current hydrologic theory; (2) how can those elements best be incorporated where they may be missing in current models; and (3) how can we evaluate competing hydrologic theories across scales and locations? We propose that hydrologic science would benefit from a model-based community synthesis effort to reframe, integrate, and evaluate different explanations of hydrologic behavior, and provide a controlled avenue to find where understanding falls short. C1 [Clark, Martyn P.] Natl Ctr Atmospher Res, Res Applicat Lab, POB 3000, Boulder, CO 80307 USA. [Schaefli, Bettina] Ecole Polytech Fed Lausanne, Sch Architecture Civil & Environm Engn, Lausanne, Switzerland. [Schaefli, Bettina] Univ Lausanne, Fac Geosci & Environm, CH-1015 Lausanne, Switzerland. [Schymanski, Stanislaus J.] Swiss Fed Inst Technol, Dept Environm Syst Sci, Zurich, Switzerland. [Samaniego, Luis] UFZ Helmholtz Ctr Environm Res, CHS, Leipzig, Germany. [Luce, Charles H.] USDA, Forest Serv, Res & Dev, Boise, ID USA. [Jackson, Bethanna M.] Victoria Univ Wellington, Sch Geog Environm & Earth Sci, Wellington, New Zealand. [Freer, Jim E.] Univ Bristol, Sch Geog Sci, Bristol, Avon, England. [Arnold, Jeffrey R.] US Army Corps Engineers, IWR JISAO, Seattle, WA USA. [Moore, R. Dan] Univ British Columbia, Dept Geog, Vancouver, BC, Canada. [Istanbulluoglu, Erkan] Univ Washington, Coll Engn, Dept Civil & Environm Engn, Seattle, WA 98195 USA. [Ceola, Serena] Univ Bologna, DICAM, Bologna, Italy. RP Clark, MP (reprint author), Natl Ctr Atmospher Res, Res Applicat Lab, POB 3000, Boulder, CO 80307 USA. EM mclark@ucar.edu RI Freer, Jim/C-7335-2009; Samaniego, Luis/G-8651-2011; Schymanski, Stanislaus/A-5303-2012; Schaefli, Bettina/B-2069-2010; Luce, Charles/A-9267-2008 OI Samaniego, Luis/0000-0002-8449-4428; Schymanski, Stanislaus/0000-0002-0950-2942; Schaefli, Bettina/0000-0003-1140-6244; Luce, Charles/0000-0002-6938-9662 NR 144 TC 4 Z9 4 U1 6 U2 9 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0043-1397 EI 1944-7973 J9 WATER RESOUR RES JI Water Resour. Res. PD MAR PY 2016 VL 52 IS 3 BP 2350 EP 2365 DI 10.1002/2015WR017910 PG 16 WC Environmental Sciences; Limnology; Water Resources SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA DK1WR UT WOS:000374706300043 ER PT J AU Carlsson, AH Fletcher, JL Rose, LF Medina, JL Leung, KP Chan, RK AF Carlsson, A. H. Fletcher, J. L. Rose, L. F. Medina, J. L. Leung, K. P. Chan, R. K. TI HYPERTROPHIC-LIKE SCAR FORMATION FOLLOWING PARTIAL THICKNESS BURN OR SKIN LOSS: A PORCINE MODEL SO WOUND REPAIR AND REGENERATION LA English DT Meeting Abstract C1 [Carlsson, A. H.; Fletcher, J. L.; Rose, L. F.; Medina, J. L.; Leung, K. P.; Chan, R. K.] US Army Inst Surg Res, Dent & Craniofacial Trauma Res & Tissue Regenerat, Jbsa Ft Sam Houston, TX USA. [Carlsson, A. H.; Fletcher, J. L.; Rose, L. F.; Chan, R. K.] US Army Inst Surg Res, Qual Skin Collaborat Adv Reconstruct & Regenerat, Jbsa Ft Sam Houston, TX USA. [Chan, R. K.] US Army Inst Surg Res, Clin Div, Jbsa Ft Sam Houston, TX USA. [Chan, R. K.] US Army Inst Surg Res, Burn Ctr, Jbsa Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1067-1927 EI 1524-475X J9 WOUND REPAIR REGEN JI Wound Repair Regen. PD MAR-APR PY 2016 VL 24 IS 2 BP A4 EP A5 PG 2 WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery GA DK8DP UT WOS:000375157700018 ER PT J AU Chen, L Zhou, J Zhao, Y Fine, D Nagaraja, S Mitrophanov, AY Reifman, J DiPietro, LA AF Chen, L. Zhou, J. Zhao, Y. Fine, D. Nagaraja, S. Mitrophanov, A. Y. Reifman, J. DiPietro, L. A. TI COLLAGEN SYNTHESIS AND DEPOSITION IN SKIN WOUNDS OF MAC-1 DEFICIENT MICE SO WOUND REPAIR AND REGENERATION LA English DT Meeting Abstract C1 [Chen, L.; Zhou, J.; Zhao, Y.; Fine, D.; DiPietro, L. A.] Univ Illinois, Ctr Wound Healing & Tissue Regenerat Periodont, Chicago, IL USA. [Nagaraja, S.; Mitrophanov, A. Y.; Reifman, J.] US Army Med Res & Mat Command, Dept Def, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1067-1927 EI 1524-475X J9 WOUND REPAIR REGEN JI Wound Repair Regen. PD MAR-APR PY 2016 VL 24 IS 2 BP A5 EP A5 PG 1 WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery GA DK8DP UT WOS:000375157700021 ER PT J AU Hall, CL Wells, AR Leung, KP AF Hall, C. L. Wells, A. R. Leung, K. P. TI PIRFENIDONE MODULATES THE TGF-beta 1-INDUCED PROFIBROTIC PHENOTYPE IN HUMAN DERMAL FIBROBLASTS SO WOUND REPAIR AND REGENERATION LA English DT Meeting Abstract C1 [Hall, C. L.; Wells, A. R.; Leung, K. P.] US Army, Dent & Craniofacial Trauma Res & Tissue Regenerat, Inst Surg Res, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1067-1927 EI 1524-475X J9 WOUND REPAIR REGEN JI Wound Repair Regen. PD MAR-APR PY 2016 VL 24 IS 2 BP A10 EP A10 PG 1 WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery GA DK8DP UT WOS:000375157700044 ER PT J AU Karna, S Tsute, C D'Arpa, P Liwu, Q Ping, C Fourcaudot, AB Kazuyoshi, Y Jeffrey, N Abercrombie, JJ Tao, Y Leung, KP AF Karna, S. Tsute, C. D'Arpa, P. Liwu, Q. Ping, C. Fourcaudot, A. B. Kazuyoshi, Y. Jeffrey, N. Abercrombie, J. J. Tao, Y. Leung, K. P. TI HOST GENOMIC RESPONSES TO PSEUDOMONAS AERUGINOSA WOUND INFECTIONS SO WOUND REPAIR AND REGENERATION LA English DT Meeting Abstract C1 [Karna, S.; Liwu, Q.; Ping, C.; Fourcaudot, A. B.; Kazuyoshi, Y.; Jeffrey, N.; Abercrombie, J. J.; Tao, Y.; Leung, K. P.] US Army, Inst Surg Reasearch Dent & Craniofacial Trauma Re, Jbsa Ft Sam Houston, TX USA. [Tsute, C.] Forsyth Inst, Cambridge, MA USA. [D'Arpa, P.] US Army, Syst & Integrat Biol Program, Ctr Environm Hlth Res, Frederick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1067-1927 EI 1524-475X J9 WOUND REPAIR REGEN JI Wound Repair Regen. PD MAR-APR PY 2016 VL 24 IS 2 BP A14 EP A15 PG 2 WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery GA DK8DP UT WOS:000375157700062 ER PT J AU Medina, JL Carlsson, AH Fourcaudot, AB Leung, KP AF Medina, J. L. Carlsson, A. H. Fourcaudot, A. B. Leung, K. P. TI SCALD MODEL OF PARTIAL THICKNESS BURNS IN C57BL/6 MICE SO WOUND REPAIR AND REGENERATION LA English DT Meeting Abstract C1 [Medina, J. L.; Carlsson, A. H.; Fourcaudot, A. B.; Leung, K. P.] US Army, Inst Surg Res, Dent & Craniofacial Trauma Res & Tissue Regenerat, Ft Sam Houston, TX 78234 USA. [Carlsson, A. H.] US Army, Inst Surg Res, Qual Skin Collaborat Adv Reconstruct & Regenerat, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1067-1927 EI 1524-475X J9 WOUND REPAIR REGEN JI Wound Repair Regen. PD MAR-APR PY 2016 VL 24 IS 2 BP A18 EP A18 PG 1 WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery GA DK8DP UT WOS:000375157700077 ER PT J AU Nagaraja, S Chen, L Zhou, J Zhao, Y Fine, D DiPietro, A Reifman, J Mitrophanov, AY AF Nagaraja, S. Chen, L. Zhou, J. Zhao, Y. Fine, D. DiPietro, A. Reifman, J. Mitrophanov, A. Y. TI MECHANISTIC DRIVERS AND MOLECULAR INDICATORS OF DELAYED INFLAMMATION RESOLUTION IN TRAUMATIC WOUNDS SO WOUND REPAIR AND REGENERATION LA English DT Meeting Abstract C1 [Nagaraja, S.; Reifman, J.; Mitrophanov, A. Y.] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, DoD Biotechnol High Performance Comp Software App, Frederick, MD USA. [Chen, L.; Zhou, J.; Zhao, Y.; Fine, D.; DiPietro, A.] Univ Illinois, Coll Dent, Ctr Wound Healing & Tissue Regenerat, Chicago, IL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1067-1927 EI 1524-475X J9 WOUND REPAIR REGEN JI Wound Repair Regen. PD MAR-APR PY 2016 VL 24 IS 2 BP A19 EP A19 PG 1 WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery GA DK8DP UT WOS:000375157700081 ER PT J AU Olekson, MA Savage, PB Leung, KP AF Olekson, M. A. Savage, P. B. Leung, K. P. TI ANTI-BIOFILM PEPTIDES AND PEPTIDE-MIMICS STIMULATE WOUND HEALING PROCESSES IN VITRO SO WOUND REPAIR AND REGENERATION LA English DT Meeting Abstract C1 [Olekson, M. A.; Leung, K. P.] US Army Inst Surg Res, Dent & Craniofacial Trauma Res & Tissue Regenerat, Ft Sam Houston, TX USA. [Savage, P. B.] Brigham Young Univ, Dept Chem & Biochem, Provo, UT 84602 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1067-1927 EI 1524-475X J9 WOUND REPAIR REGEN JI Wound Repair Regen. PD MAR-APR PY 2016 VL 24 IS 2 BP A19 EP A20 PG 2 WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery GA DK8DP UT WOS:000375157700085 ER EF