FN Thomson Reuters Web of Science™
VR 1.0
PT J
AU Bohnet, JG
Sawyer, BC
Britton, JW
Wall, ML
Rey, AM
Foss-Feig, M
Bollinger, JJ
AF Bohnet, Justin G.
Sawyer, Brian C.
Britton, Joseph W.
Wall, Michael L.
Rey, Ana Maria
Foss-Feig, Michael
Bollinger, John J.
TI Quantum spin dynamics and entanglement generation with hundreds of
trapped ions
SO SCIENCE
LA English
DT Article
ID RANGE INTERACTIONS; OPTICAL LATTICE; STATES; ATOMS; PROPAGATION;
SIMULATION; NOISE
AB Quantum simulation of spin models can provide insight into problems that are difficult or impossible to study with classical computers. Trapped ions are an established platform for quantum simulation, but only systems with fewer than 20 ions have demonstrated quantum correlations. We studied quantum spin dynamics arising from an engineered, homogeneous Ising interaction in a two-dimensional array of Be-9(+) ions in a Penning trap. We verified entanglement in spin-squeezed states of up to 219 ions, directly observing 4.0 +/- 0.9 decibels of spectroscopic enhancement, and observed states with non-Gaussian statistics consistent with oversqueezed states. The good agreement with ab initio theory that includes interactions and decoherence lays the groundwork for simulations of the transverse-field Ising model with variable-range interactions, which are generally intractable with classical methods.
C1 [Bohnet, Justin G.; Sawyer, Brian C.; Britton, Joseph W.; Bollinger, John J.] NIST, Boulder, CO 80305 USA.
[Sawyer, Brian C.] Georgia Tech Res Inst, Atlanta, GA 30332 USA.
[Britton, Joseph W.; Foss-Feig, Michael] Army Res Lab, Adelphi, MD 20783 USA.
[Wall, Michael L.; Rey, Ana Maria] Univ Colorado, NIST, Joint Inst Lab Astrophys, Boulder, CO 80309 USA.
[Wall, Michael L.] Univ Colorado, Boulder, CO 80309 USA.
[Rey, Ana Maria] Univ Colorado, Dept Phys, Boulder, CO 80309 USA.
[Foss-Feig, Michael] Joint Quantum Inst, Gaithersburg, MD 20899 USA.
[Foss-Feig, Michael] NIST, Gaithersburg, MD 20899 USA.
RP Bohnet, JG; Bollinger, JJ (reprint author), NIST, Boulder, CO 80305 USA.
EM justin.bohnet@nist.gov; jjb@nist.gov
FU NSF [PHY 1521080]; JILA-NSF [PFC-1125844]; Army Research Office; Air
Force Office of Scientific Research; Multidisciplinary University
Research Initiative; National Research Council Research Associateship
Award at NIST; NIST
FX We thank D. Hume, J. Thompson, A. Keith, J. Schachenmayer, A.
Safavi-Naini, M. Gaerttner, and M. Kastner for helpful discussions.
Supported by NSF grant PHY 1521080, JILA-NSF grant PFC-1125844, the Army
Research Office, and the Air Force Office of Scientific Research and its
Multidisciplinary University Research Initiative (A.M.R.) and by a
National Research Council Research Associateship Award at NIST (J.G.B.,
M.F.-F., and M.L.W.). All authors acknowledge financial support from
NIST. This manuscript is the contribution of NIST and is not subject to
U.S. copyright.
NR 47
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U1 16
U2 28
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 0036-8075
EI 1095-9203
J9 SCIENCE
JI Science
PD JUN 10
PY 2016
VL 352
IS 6291
BP 1297
EP 1301
DI 10.1126/science.aad9958
PG 5
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DO7ON
UT WOS:000377972000035
PM 27284189
ER
PT J
AU Vijay, PV
Soti, PR
GangaRao, HVS
Lampo, RG
Clarkson, JD
AF Vijay, P. V.
Soti, Piyush R.
GangaRao, Hota V. S.
Lampo, Richard G.
Clarkson, John D.
TI Design and evaluation of an integrated FRP composite wicket gate
SO COMPOSITE STRUCTURES
LA English
DT Article
DE Cellular FRP deck; Sandwich panel; Deck stiffness; Hydraulic structure;
Wicket gate
ID PERFORMANCE
AB Hydraulic gates need to be light-weight, corrosion-resistant, maintenance-free, and durable with high endurance under fatigue loads. All of these requirements could be challenges to be met using conventional materials like steel and concrete. However, with the emergence of advanced Fiber Reinforced Polymer (FRP) composites for waterway structures, it has now been possible to achieve all of these physical and performance requirements in a cost-effective manner. Due to their lightness, excellent corrosion and wear resistance along with superior thermo-mechanical properties, FRPs have emerged as one of the best alternatives in the field of civil infrastructure. This paper covers several aspects of the design, manufacturing, testing, analysis, and field implementation of a novel integrated FRP wicket gate in Mississippi River lock and dam. The cellular FRP panel with foam core and integrated stiffening and fastening components has been analyzed to compute the bending stiffness both theoretically and experimentally and a good correlation has been obtained. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Vijay, P. V.; GangaRao, Hota V. S.] W Virginia Univ, Constructed Facil Ctr, Dept CEE, Morgantown, WV 26506 USA.
[Soti, Piyush R.] W Virginia Univ, Dept CEE, Morgantown, WV 26506 USA.
[Lampo, Richard G.] US Army Corps Engineers, Champaign, IL 61826 USA.
[Clarkson, John D.] US Army Corps Engineers, Huntington, WV 25701 USA.
RP Vijay, PV (reprint author), W Virginia Univ, Constructed Facil Ctr, Dept CEE, Morgantown, WV 26506 USA.
EM p.vijay@mail.wvu.edu
FU U.S. Army Corps of Engineers (USACE)
FX The writers gratefully acknowledge the financial support from U.S. Army
Corps of Engineers (USACE). Support from all the engineering and
supporting staff of USACE and Rock Island lock and dam site is sincerely
acknowledged.
NR 29
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U1 3
U2 16
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0263-8223
EI 1879-1085
J9 COMPOS STRUCT
JI Compos. Struct.
PD JUN 10
PY 2016
VL 145
BP 149
EP 161
DI 10.1016/j.compstruct.2016.01.093
PG 13
WC Materials Science, Composites
SC Materials Science
GA DI4PO
UT WOS:000373482000014
ER
PT J
AU Lisenkov, I
Tyberkevych, V
Levin-Pompetzki, L
Bankowski, E
Meitzler, T
Nikitov, S
Slavin, A
AF Lisenkov, Ivan
Tyberkevych, Vasyl
Levin-Pompetzki, Luke
Bankowski, Elena
Meitzler, Thomas
Nikitov, Sergey
Slavin, Andrei
TI y Interaction of Microwave Photons with Nanostructured Magnetic
Metasurfaces
SO PHYSICAL REVIEW APPLIED
LA English
DT Article
ID ELECTROMAGNETIC-FIELDS; METAMATERIALS; RESONANCES
AB We develop a theoretical formalism for the description of the interaction of microwave photons with a thin (compared to the photon wavelength) magnetic metasurface comprised of dipolarly interacting nanoscale magnetic elements. We derive a scattering matrix describing the processes of photon transmission and reflection at the metasurface boundary. As an example of the use of the developed formalism, we demonstrate that the introduction of a magnetic metasurface inside a microstrip electromagnetic waveguide quantitatively changes the dispersion relation of the fundamental waveguide mode, opening a nonpropagation frequency band gap in the waveguide spectrum. The frequency position and the width of the band gap are dependent on the waveguide thickness and can be controlled dynamically by switching the magnetic ground state of the metasurface. For sufficiently thin waveguides, the position of the band gap is shifted from the resonance absorption frequency of the metasurface. In such a case, the magnetic metasurface inside a waveguide works as an efficient reflector, as the energy absorption in the metasurface is small, and most of the electromagnetic energy inside the nonpropagation band gap is reflected.
C1 [Lisenkov, Ivan; Tyberkevych, Vasyl; Levin-Pompetzki, Luke; Slavin, Andrei] Oakland Univ, Dept Phys, 2200 North Squirrel Rd, Rochester, MI 48309 USA.
[Lisenkov, Ivan; Nikitov, Sergey] RAS, Kotelnikov Inst Radio Engn & Elect, 11-7 Mokhovaya, Moscow 125009, Moscow, Russia.
[Bankowski, Elena; Meitzler, Thomas] US Army TARDEC, Warren, MI 48397 USA.
[Nikitov, Sergey] Moscow Inst Phys & Technol, 9 Inst Skij, Dolgoprudnyi 141700, Moscow Region, Russia.
[Nikitov, Sergey] Saratov NG Chernyshevskii State Univ, 83 Astrakhanskaya, Saratov 410012, Saratov, Russia.
RP Lisenkov, I (reprint author), Oakland Univ, Dept Phys, 2200 North Squirrel Rd, Rochester, MI 48309 USA.; Lisenkov, I (reprint author), RAS, Kotelnikov Inst Radio Engn & Elect, 11-7 Mokhovaya, Moscow 125009, Moscow, Russia.
EM ivan.lisenkov@phystech.edu
RI Meitzler, Thomas/D-1065-2017
FU National Science Foundation of the USA [ECCS-1305586]; U.S. Army
[TARDEC, RDECOM]; DARPA grant "Coherent Information Transduction between
Photons, Magnons, and Electric Charge Carriers"; Center for NanoFerroic
Devices; Nanoelectronics Research Initiative; Russian Scientific
Foundation [14-19-00760]
FX This work is supported in part by Grant No. ECCS-1305586 from the
National Science Foundation of the USA, by the U.S. Army Contract No.
TARDEC, RDECOM, by the DARPA grant "Coherent Information Transduction
between Photons, Magnons, and Electric Charge Carriers," and by the
Center for NanoFerroic Devices and the Nanoelectronics Research
Initiative. I.L. and S.N. acknowledge the Russian Scientific Foundation
Grant No. 14-19-00760 for financial support.
NR 40
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Z9 0
U1 5
U2 14
PU AMER PHYSICAL SOC
PI COLLEGE PK
PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA
SN 2331-7019
J9 PHYS REV APPL
JI Phys. Rev. Appl.
PD JUN 9
PY 2016
VL 5
IS 6
AR 064005
DI 10.1103/PhysRevApplied.5.064005
PG 11
WC Physics, Applied
SC Physics
GA DO1AP
UT WOS:000377510900002
ER
PT J
AU Kaplan, D
Mills, K
Lee, J
Torrel, S
Swaminathan, V
AF Kaplan, D.
Mills, K.
Lee, J.
Torrel, S.
Swaminathan, V.
TI Excitation intensity dependent photoluminescence of annealed
two-dimensional MoS2 grown by chemical vapor deposition
SO JOURNAL OF APPLIED PHYSICS
LA English
DT Article
ID MONOLAYER MOLYBDENUM-DISULFIDE; LAYER MOS2; TRANSPORT-PROPERTIES;
EXFOLIATED MOS2; MONO LAYER; SEMICONDUCTORS; DEFECTS; SURFACES;
EXCITONS; TRIONS
AB Here, we present detailed results of Raman and photoluminescence (PL) characterization of monolayers of MoS2 grown by chemical vapor deposition (CVD) on SiO2/Si substrates after thermal annealing at 150 degrees C, 200 degrees C, and 250 degrees C in an argon atmosphere. In comparison to the as-grown monolayers, annealing in the temperature range of 150-250 degrees C brings about significant changes in the band edge luminescence. It is observed that annealing at 150 degrees C gives rise to a 100-fold increase in the PL intensity and produces a strong band at 1.852 eV attributed to a free-to-bound transition that dominates over the band edge excitonic luminescence. This band disappears for the higher annealing temperatures. The improvement in PL after the 200 degrees C anneal is reduced in comparison to that obtained after the 150 degrees C anneal; this is suggested to arise from a decrease in the non-radiative lifetime caused by the creation of sulfur di-vacancies. Annealing at 250 degrees C degrades the PL in comparison to the as-grown sample because of the onset of disorder/decomposition of the sample. It is clear that the PL features of the CVD-grown MoS2 monolayer are profoundly affected by thermal annealing in Ar atmosphere. However, further detailed studies are needed to identify, unambiguously, the role of native defects and/or adsorbed species in defining the radiative channels in annealed samples so that the beneficial effect of improvement in the optical efficiency of the MoS2 monolayers can be leveraged for various device applications.
C1 [Kaplan, D.; Swaminathan, V.] US Army RDECOM ARDEC, Fuze Precis Armaments & Technol Directorate, Picatinny Arsenal, NJ 07806 USA.
[Mills, K.] US Army RDECOM ARDEC, Energet Warheads & Mfg Technol Directorate, Picatinny Arsenal, NJ 07806 USA.
[Lee, J.] Agcy Def Dev, POB 35, Yuseong 305600, Daejeon, South Korea.
[Torrel, S.] Rutgers State Univ, Dept Mat Sci & Engn, Piscataway, NJ 08854 USA.
[Lee, J.] US Army RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA.
RP Kaplan, D (reprint author), US Army RDECOM ARDEC, Fuze Precis Armaments & Technol Directorate, Picatinny Arsenal, NJ 07806 USA.
NR 47
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Z9 2
U1 24
U2 41
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0021-8979
EI 1089-7550
J9 J APPL PHYS
JI J. Appl. Phys.
PD JUN 7
PY 2016
VL 119
IS 21
AR 214301
DI 10.1063/1.4948662
PG 9
WC Physics, Applied
SC Physics
GA DQ0WS
UT WOS:000378923100017
ER
PT J
AU Sarney, WL
Svensson, SP
Lin, Y
Donetsky, D
Shterengas, L
Kipshidze, G
Belenky, G
AF Sarney, W. L.
Svensson, S. P.
Lin, Y.
Donetsky, D.
Shterengas, L.
Kipshidze, G.
Belenky, G.
TI Extremely small bandgaps, engineered by controlled multi-scale ordering
in InAsSb
SO JOURNAL OF APPLIED PHYSICS
LA English
DT Article
ID STRAINED-LAYER SUPERLATTICES; VAPOR-PHASE EPITAXY; CELL CONFIGURATION;
INAS1-XSBX; PROPOSAL; ALLOYS; GROWTH; FILMS; GAINP
AB The relationship between the effective bandgap and the crystalline structure in ordered InAsSb material has been studied. Modulation of the As/Sb ratio was induced along the growth direction during molecular beam epitaxy, producing a strained layer superlattice. To enable the use of concentration ratios near unity in both layers in the period, the structures were grown with negligible net strain on a virtual substrate with a lattice constant considerably larger than that of GaSb. The bandgap line-up of InAsSb layers with different compositions is such that a type II superlattice is formed, which exhibits smaller bandgaps than either of the two constituents. It can also be smaller than the possible minimum direct-bandgap of the alloy. From observations of CuPt ordering in bulk layers with small amounts of strain of both signs, we postulate that strain is the main driving force for atomic ordering in InAsSb. Because the modulated structures exhibit small but opposing amounts of strain, both layers in the period exhibit ordering at the atomic scale throughout the structure. Since the strain can be controlled, the ordering can be controlled and sustained for arbitrary thick layers, unlike the situation in uniform bulk layers where the residual strain eventually leads to dislocation formation. This offers a unique way of using ordering at two different scales to engineer the band-structure. Published by AIP Publishing.
C1 [Sarney, W. L.; Svensson, S. P.] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
[Lin, Y.; Donetsky, D.; Shterengas, L.; Kipshidze, G.; Belenky, G.] SUNY Stony Brook, Dept Elect & Comp Engn, Stony Brook, NY 11794 USA.
RP Sarney, WL (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
OI LIN, YOUXI/0000-0002-9092-2302
FU U.S. National Science Foundation [DMR1160843]; U.S. Army Research Office
[W911NF-16-20053]
FX This work was supported by the U.S. National Science Foundation through
Grant No. DMR1160843 and by the U.S. Army Research Office through Award
W911NF-16-20053.
NR 24
TC 1
Z9 1
U1 5
U2 10
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0021-8979
EI 1089-7550
J9 J APPL PHYS
JI J. Appl. Phys.
PD JUN 7
PY 2016
VL 119
IS 21
AR 215704
DI 10.1063/1.4952754
PG 6
WC Physics, Applied
SC Physics
GA DQ0WS
UT WOS:000378923100051
ER
PT J
AU Kostereva, NV
Wang, Y
Fletcher, DR
Unadkat, JV
Schnider, JT
Komatsu, C
Yang, Y
Stolz, DB
Davis, MR
Plock, JA
Gorantla, VS
AF Kostereva, Nataliya V.
Wang, Yong
Fletcher, Derek R.
Unadkat, Jignesh V.
Schnider, Jonas T.
Komatsu, Chiaki
Yang, Yang
Stolz, Donna B.
Davis, Michael R.
Plock, Jan A.
Gorantla, Vijay S.
TI IGF-1 and Chondroitinase ABC Augment Nerve Regeneration after
Vascularized Composite Limb Allotransplantation
SO PLOS ONE
LA English
DT Article
ID GROWTH-FACTOR-I; MUSCLE REINNERVATION; AXONAL REGENERATION;
PROTEOGLYCANS; EXPRESSION; SYSTEM; GLYCOSAMINOGLYCANS; CELLS; FK506
AB Impaired nerve regeneration and inadequate recovery of motor and sensory function following peripheral nerve repair remain the most significant hurdles to optimal functional and quality of life outcomes in vascularized tissue allotransplantation (VCA). Neurotherapeutics such as Insulin-like Growth Factor-1 (IGF-1) and chondroitinase ABC (CH) have shown promise in augmenting or accelerating nerve regeneration in experimental models and may have potential in VCA. The aim of this study was to evaluate the efficacy of low dose IGF-1, CH or their combination (IGF-1+CH) on nerve regeneration following VCA. We used an allogeneic rat hind limb VCA model maintained on low-dose FK506 (tacrolimus) therapy to prevent rejection. Experimental animals received neurotherapeutics administered intraoperatively as multiple intraneural injections. The IGF-1 and IGF-1+CH groups received daily IGF-1 (intramuscular and intraneural injections). Histomorphometry and immunohistochemistry were used to evaluate outcomes at five weeks. Overall, compared to controls, all experimental groups showed improvements in nerve and muscle (gastrocnemius) histomorphometry. The IGF-1 group demonstrated superior distal regeneration as confirmed by Schwann cell (SC) immunohistochemistry as well as some degree of extrafascicular regeneration. IGF-1 and CH effectively promote nerve regeneration after VCA as confirmed by histomorphometric and immunohistochemical outcomes.
C1 [Kostereva, Nataliya V.; Wang, Yong; Fletcher, Derek R.; Unadkat, Jignesh V.; Schnider, Jonas T.; Komatsu, Chiaki; Yang, Yang; Plock, Jan A.; Gorantla, Vijay S.] Univ Pittsburgh, Dept Plast Surg, Thomas E Starzl Transplant Inst, Pittsburgh, PA USA.
[Kostereva, Nataliya V.; Plock, Jan A.; Gorantla, Vijay S.] Univ Pittsburgh, McGowan Inst Regenerat Med, Pittsburgh, PA USA.
[Wang, Yong] East Hosp Shanghai, Dept Trauma Surg, Shanghai, Peoples R China.
[Stolz, Donna B.] Univ Pittsburgh, Ctr Biol Imaging, Pittsburgh, PA USA.
[Davis, Michael R.] US Army, Inst Surg Res, San Antonio Mil Med Ctr, 3698 Chambers Rd, San Antonio, TX USA.
[Fletcher, Derek R.] Univ Penn, Div Plast Surg, Philadelphia, PA 19104 USA.
[Schnider, Jonas T.] Univ Hosp Bern, Inselspital, Dept Plast & Hand Surg, CH-3010 Bern, Switzerland.
[Yang, Yang] Fourth Mil Med Univ, Xijing Hosp, Dept Plast & Reconstruct Surg, Xian 710032, Xincheng, Peoples R China.
[Plock, Jan A.] Univ Zurich Hosp, Div Plast & Hand Surg, CH-8091 Zurich, Switzerland.
RP Gorantla, VS (reprint author), Univ Pittsburgh, Dept Plast Surg, Thomas E Starzl Transplant Inst, Pittsburgh, PA USA.; Gorantla, VS (reprint author), Univ Pittsburgh, McGowan Inst Regenerat Med, Pittsburgh, PA USA.
EM gorantlavs@upmc.edu
FU Department of Defense (Congressionally Directed Medical Research
Programs) [W81XWH-11-2-0215]
FX The study was supported by a generous grant by the Department of Defense
(Congressionally Directed Medical Research Programs)- Grant #
W81XWH-11-2-0215, PI: Vijay Gorantla (URL: http://cdmrp.army.mil). The
sponsors had no role in study design, data collection and analysis,
decision to publish, or preparation of the manuscript.
NR 31
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U1 1
U2 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 7
PY 2016
VL 11
IS 6
AR e0156149
DI 10.1371/journal.pone.0156149
PG 17
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DO1TC
UT WOS:000377561000008
PM 27272754
ER
PT J
AU Petrache, CM
Guo, S
Ayangeakaa, AD
Garg, U
Matta, JT
Nayak, BK
Patel, D
Carpenter, MP
Chiara, CJ
Janssens, RVF
Kondev, FG
Lauritsen, T
Seweryniak, D
Zhu, S
Ghugre, SS
Palit, R
AF Petrache, C. M.
Guo, S.
Ayangeakaa, A. D.
Garg, U.
Matta, J. T.
Nayak, B. K.
Patel, D.
Carpenter, M. P.
Chiara, C. J.
Janssens, R. V. F.
Kondev, F. G.
Lauritsen, T.
Seweryniak, D.
Zhu, S.
Ghugre, S. S.
Palit, R.
TI Triaxiality and exotic rotations at high spins in Ce-134
SO PHYSICAL REVIEW C
LA English
DT Article
ID COINCIDENCE DATA SETS; MASS REGION; BANDS; STATES; CE; COLLECTIVITY;
EXCITATIONS; ISOTOPES; ND-136; MODEL
AB High-spin states in Ce-134 have been investigated using the Cd-116(Ne-22,4n) reaction and the Gammasphere array. The level scheme has been extended to an excitation energy of similar to 30 MeV and spin similar to 54 (h) over bar. Two new dipole bands and four new sequences of quadrupole transitions were identified. Several new transitions have been added to a number of known bands. One of the strongly populated dipole bands was revised and placed differently in the level scheme, resolving a discrepancy between experiment and model calculations reported previously. Configurations are assigned to the observed bands based on cranked Nilsson-Strutinsky calculations. A coherent understanding of the various excitations, both at low and high spins, is thus obtained, supporting an interpretation in terms of coexistence of stable triaxial, highly deformed, and superdeformed shapes up to very high spins. Rotations around different axes of the triaxial nucleus, and sudden changes of the rotation axis in specific configurations, are identified, further elucidating the nature of high-spin collective excitations in the A = 130 mass region.
C1 [Petrache, C. M.; Guo, S.] Univ Paris Saclay, CNRS IN2P3, Ctr Sci Nucl & Sci Mat, Batiment 104-108, F-91405 Orsay, France.
[Ayangeakaa, A. D.; Garg, U.; Matta, J. T.; Nayak, B. K.; Patel, D.] Univ Notre Dame, Dept Phys, Notre Dame, IN 46556 USA.
[Ayangeakaa, A. D.; Carpenter, M. P.; Chiara, C. J.; Janssens, R. V. F.; Lauritsen, T.; Seweryniak, D.; Zhu, S.] Argonne Natl Lab, Div Phys, Argonne, IL 60439 USA.
[Chiara, C. J.] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA.
[Kondev, F. G.] Argonne Natl Lab, Nucl Engn Div, 9700 S Cass Ave, Argonne, IL 60439 USA.
[Ghugre, S. S.] UGC DAE Consortium Sci Res, Kolkata 700098, India.
[Palit, R.] Tata Inst Fundamental Res, Homi Bhabha Rd, Bombay 400005, Maharashtra, India.
[Palit, R.] Univ Notre Dame, Joint Inst Nucl Astrophys, Notre Dame, IN 46556 USA.
[Matta, J. T.] Oak Ridge Natl Lab, Div Phys, Oak Ridge, TN 37830 USA.
[Nayak, B. K.] Bhabha Atom Res Ctr, Div Nucl Phys, Bombay 400085, Maharashtra, India.
[Patel, D.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
[Chiara, C. J.] US Army Res Lab, Adelphi, MD 20783 USA.
RP Petrache, CM (reprint author), Univ Paris Saclay, CNRS IN2P3, Ctr Sci Nucl & Sci Mat, Batiment 104-108, F-91405 Orsay, France.
RI Palit, Rudrajyoti/F-5185-2012
FU US National Science Foundation [PHY07-58100, PHY-0822648, PHY-1068192,
PHY-1419765]; US Department of Energy, Office of Nuclear Physics
[DE-FG02-94ER40834, DE-AC02-06CH11357]
FX C.M.P. expresses his gratitude to Prof. I. Ragnarsson for providing the
CNS codes, for the training on how to use them, and for enlightening
comments on the theoretical interpretation of the results. This work has
been supported in part by the US National Science Foundation (Grants No.
PHY07-58100, No. PHY-0822648, No. PHY-1068192, and No. PHY-1419765), the
US Department of Energy, Office of Nuclear Physics, under Grant No.
DE-FG02-94ER40834 (UM), and Contract No. DE-AC02-06CH11357 (ANL). This
research used resources of ANL's ATLAS facility, which is a DOE Office
of Science User Facility.
NR 36
TC 1
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U1 3
U2 5
PU AMER PHYSICAL SOC
PI COLLEGE PK
PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA
SN 2469-9985
EI 2469-9993
J9 PHYS REV C
JI Phys. Rev. C
PD JUN 6
PY 2016
VL 93
IS 6
AR 064305
DI 10.1103/PhysRevC.93.064305
PG 18
WC Physics, Nuclear
SC Physics
GA DN8AW
UT WOS:000377302300002
ER
PT J
AU Giersing, BK
Modjarrad, K
Kaslow, DC
Okwo-Bele, JM
Moorthy, VS
AF Giersing, Birgitte K.
Modjarrad, Kayvon
Kaslow, David C.
Okwo-Bele, Jean-Marie
Moorthy, Vasee S.
TI The 2016 Vaccine Development Pipeline: A special issue from the World
Health Organization Product Development for Vaccine Advisory Committee
(PDVAC) Preface
SO VACCINE
LA English
DT Editorial Material
C1 [Giersing, Birgitte K.; Okwo-Bele, Jean-Marie; Moorthy, Vasee S.] WHO, CH-1211 Geneva, Switzerland.
[Modjarrad, Kayvon] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Kaslow, David C.] PATH, Seattle, WA USA.
RP Giersing, BK (reprint author), WHO, CH-1211 Geneva, Switzerland.
FU World Health Organization [001]
NR 0
TC 1
Z9 1
U1 0
U2 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
EI 1873-2518
J9 VACCINE
JI Vaccine
PD JUN 3
PY 2016
VL 34
IS 26
SI SI
BP 2863
EP 2864
DI 10.1016/j.vaccine.2016.04.041
PG 2
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA DP3AQ
UT WOS:000378365200001
PM 27108194
ER
PT J
AU Giersing, BK
Modjarrad, K
Kaslow, DC
Moorthy, VS
AF Giersing, Birgitte K.
Modjarrad, Kayvon
Kaslow, David C.
Moorthy, Vasee S.
CA WHO Prod Dev Vaccines Advisory Com
TI Report from the World Health Organization's Product Development for
Vaccines Advisory Committee (PDVAC) meeting, Geneva, 7-9th Sep 2015
SO VACCINE
LA English
DT Article
DE Vaccine; Candidate; Product development; PPC; LMIC
ID DEVELOPING-COUNTRIES; DIARRHEAL DISEASE; DOUBLE-BLIND; IMMUNOGENICITY;
EFFICACY; CHILDREN; SAFETY; TRIAL
AB There are more vaccines in development, against a greater number of pathogens, than ever before. A challenge with this exceptional level of activity and investment is how to select and resource the most promising approaches to have the most significant impact on public health. The WHO Product Development for Vaccines Advisory Committee (PDVAC) was established in 2014 to provide strategic advice and recommendations to WHO for vaccines in clinical development that could have a significant impact on public health in low and middle income countries. On 7-9th September 2015, PDVAC was convened for the second time, when the committee reviewed vaccine developments in 24 disease areas. This report summarises the key recommendations from that consultation. (C) 2016 World Health Organization; licensee Elsevier Ltd.
C1 [Giersing, Birgitte K.; Moorthy, Vasee S.] WHO, Initiat Vaccine Res, 20 Ave Appia, CH-1211 Geneva 27, Switzerland.
[Modjarrad, Kayvon] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA.
[Kaslow, David C.] PATH, Seattle, WA 98109 USA.
RP Moorthy, VS (reprint author), WHO, Initiat Vaccine Res, 20 Ave Appia, CH-1211 Geneva 27, Switzerland.
EM moorthyv@who.int
FU World Health Organization [001]
NR 12
TC 3
Z9 3
U1 0
U2 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
EI 1873-2518
J9 VACCINE
JI Vaccine
PD JUN 3
PY 2016
VL 34
IS 26
SI SI
BP 2865
EP 2869
DI 10.1016/j.vaccine.2016.02.078
PG 5
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA DP3AQ
UT WOS:000378365200002
PM 26993336
ER
PT J
AU Giersing, BK
Dastgheyb, SS
Modjarrad, K
Moorthy, V
AF Giersing, Birgitte K.
Dastgheyb, Sana S.
Modjarrad, Kayvon
Moorthy, Vasee
TI Status of vaccine research and development of vaccines for
Staphylococcus aureus
SO VACCINE
LA English
DT Article
DE Methicillin-resistant S. aureus (MRSA); Skin and soft tissue infections;
Multi-antigen approaches; Vaccine; Antibody
ID UNITED-STATES; S. AUREUS; INFECTIONS; DISEASE; IMMUNOGENICITY;
MORTALITY; EFFICACY; PROGRESS; PROFILE; BURDEN
AB Staphylococcus aureus is a highly versatile gram positive bacterium that is resident as an asymptomatic colonizer on the skin and in the nasopharynx of approximately 30% of individuals. Nasopharyngeal colonization is a risk for acquiring S. aureus infections, which can cause a range of clinical symptoms that are commonly associated with skin and soft-tissue infections. The emergence of S. aureus strains that are highly resistant to antimicrobials has recently become a major public health concern. In low-income countries the incidence of S. aureus disease is highest in neonates and children up to one year of age and mortality rates are estimated to be up to 50%. In the United States, S. aureus infection accounts for approximately 300,000 hospitalizations per year. A vaccine against multi-drug resistant S. aureus, therefore, is urgently needed. Two vaccine candidates have previously been evaluated in late-stage clinical trials but have not demonstrated efficacy. At present, one vaccine candidate and two monoclonal antibody are undergoing clinical evaluation in target groups at high risk for S. aureus infection. This review provides an overview of current vaccine development efforts and presents the major technical and regulatory challenges to developing a licensed S. aureus vaccine. (C) 2016 World Health Organization; licensee Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org(licensesiby/3.0/).
C1 [Giersing, Birgitte K.; Moorthy, Vasee] WHO, Initiat Vaccine Res, 20 Ave Appia, CH-1211 Geneva 27, Switzerland.
[Dastgheyb, Sana S.] Thomas Jefferson Univ, Sidney Kimmel Med Coll, Philadelphia, PA 19107 USA.
[Modjarrad, Kayvon] Walter Reed Army Inst Res, Bethesda, MD USA.
RP Giersing, BK (reprint author), WHO, Initiat Vaccine Res, 20 Ave Appia, CH-1211 Geneva 27, Switzerland.
EM giersingb@who.int
OI Dastgheyb, Sana/0000-0001-8275-1614
FU World Health Organization [001]
NR 38
TC 5
Z9 5
U1 12
U2 13
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
EI 1873-2518
J9 VACCINE
JI Vaccine
PD JUN 3
PY 2016
VL 34
IS 26
SI SI
BP 2962
EP 2966
DI 10.1016/j.vaccine.2016.03.110
PG 5
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA DP3AQ
UT WOS:000378365200020
PM 27105559
ER
PT J
AU Robb, ML
Eller, LA
Kibuuka, H
Rono, K
Maganga, L
Nitayaphan, S
Kroon, E
Sawe, FK
Sinei, S
Sriplienchan, S
Jagodzinski, LL
Malia, J
Manak, M
de Souza, MS
Tovanabutra, S
Sanders-Buell, E
Rolland, M
Dorsey-Spitz, J
Eller, MA
Milazzo, M
Li, Q
Lewandowski, A
Wu, H
Swann, E
O'Connell, RJ
Peel, S
Dawson, P
Kim, JH
Michael, NL
AF Robb, Merlin L.
Eller, Leigh A.
Kibuuka, Hannah
Rono, Kathleen
Maganga, Lucas
Nitayaphan, Sorachai
Kroon, Eugene
Sawe, Fred K.
Sinei, Samuel
Sriplienchan, Somchai
Jagodzinski, Linda L.
Malia, Jennifer
Manak, Mark
de Souza, Mark S.
Tovanabutra, Sodsai
Sanders-Buell, Eric
Rolland, Morgane
Dorsey-Spitz, Julie
Eller, Michael A.
Milazzo, Mark
Li, Qun
Lewandowski, Andrew
Wu, Hao
Swann, Edith
O'Connell, Robert J.
Peel, Sheila
Dawson, Peter
Kim, Jerome H.
Michael, Nelson L.
CA RV 217 Study Team
TI Prospective Study of Acute HIV-1 Infection in Adults in East Africa and
Thailand
SO NEW ENGLAND JOURNAL OF MEDICINE
LA English
DT Article
ID VIRUS TYPE-1 INFECTION; T-CELL-ACTIVATION; VIRAL LOAD; SET-POINT;
ANTIRETROVIRAL THERAPY; RNA LEVELS; 1ST YEAR; TRANSMISSION; DYNAMICS;
PROGRESSION
AB BACKGROUND
Acute human immunodeficiency virus type 1 (HIV-1) infection is a major contributor to transmission of HIV-1. An understanding of acute HIV-1 infection may be important in the development of treatment strategies to eradicate HIV-1 or achieve a functional cure.
METHODS
We performed twice-weekly qualitative plasma HIV-1 RNA nucleic acid testing in 2276 volunteers who were at high risk for HIV-1 infection. For participants in whom acute HIV-1 infection was detected, clinical observations, quantitative measurements of plasma HIV-1 RNA levels (to assess viremia) and HIV antibodies, and results of immuno-phenotyping of lymphocytes were obtained twice weekly.
RESULTS
Fifty of 112 volunteers with acute HIV-1 infection had two or more blood samples collected before HIV-1 antibodies were detected. The median peak viremia (6.7 log 10 copies per milliliter) occurred 13 days after the first sample showed reactivity on nucleic acid testing. Reactivity on an enzyme immunoassay occurred at a median of 14 days. The nadir of viremia (4.3 log 10 copies per milliliter) occurred at a median of 31 days and was nearly equivalent to the viral-load set point, the steady-state viremia that persists durably after resolution of acute viremia (median plasma HIV-1 RNA level, 4.4 log 10 copies per milliliter). The peak viremia and downslope were correlated with the viralload set point. Clinical manifestations of acute HIV-1 infection were most common just before and at the time of peak viremia. A median of one symptom of acute HIV-1 infection was recorded at a median of two study visits, and a median of one sign of acute HIV-1 infection was recorded at a median of three visits.
CONCLUSIONS
The viral-load set point occurred at a median of 31 days after the first detection of plasma viremia and correlated with peak viremia. Few symptoms and signs were observed during acute HIV-1 infection, and they were most common before peak viremia. (Funded by the Department of Defense and the National Institute of Allergy and Infectious Diseases.)
C1 [Robb, Merlin L.; Eller, Leigh A.; Jagodzinski, Linda L.; Malia, Jennifer; Manak, Mark; Tovanabutra, Sodsai; Sanders-Buell, Eric; Rolland, Morgane; Dorsey-Spitz, Julie; Eller, Michael A.; Milazzo, Mark; Li, Qun; Peel, Sheila; Kim, Jerome H.; Michael, Nelson L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
[Robb, Merlin L.; Eller, Leigh A.; Manak, Mark; Tovanabutra, Sodsai; Sanders-Buell, Eric; Rolland, Morgane; Dorsey-Spitz, Julie; Eller, Michael A.; Milazzo, Mark] Henry M Jackson Fdn Adv Mil Med, Rockville, MD USA.
[Swann, Edith] NIAID, Div Aids, NIH, Rockville, MD USA.
[Lewandowski, Andrew; Wu, Hao; Dawson, Peter] Emmes, Rockville, MD USA.
[Kibuuka, Hannah] Makerere Univ, Walter Reed Project, Kampala, Uganda.
[Rono, Kathleen; Sawe, Fred K.; Sinei, Samuel] Walter Reed Project, Kericho, Kenya.
[Maganga, Lucas] Mbeya Med Res Ctr, Mbeya, Tanzania.
[Nitayaphan, Sorachai; Kroon, Eugene; Sriplienchan, Somchai; de Souza, Mark S.; O'Connell, Robert J.] Armed Forces Res Inst Med Sci, Bangkok, Thailand.
[Kroon, Eugene; de Souza, Mark S.] SEARCH, Thai Red Cross AIDS Res Ctr, Bangkok, Thailand.
[Kim, Jerome H.] Int Vaccine Inst, Seoul, South Korea.
RP Robb, ML (reprint author), US Mil HIV Res Program, 6720A Rockledge Dr, Bethesda, MD 20817 USA.
EM mrobb@hivresearch.org
OI Manak, Mark /0000-0002-9217-9129
FU Department of Defense; National Institute of Allergy and Infectious
Diseases
FX Funded by the Department of Defense and the National Institute of
Allergy and Infectious Diseases.
NR 39
TC 12
Z9 12
U1 2
U2 3
PU MASSACHUSETTS MEDICAL SOC
PI WALTHAM
PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA
SN 0028-4793
EI 1533-4406
J9 NEW ENGL J MED
JI N. Engl. J. Med.
PD JUN 2
PY 2016
VL 374
IS 22
BP 2120
EP 2130
DI 10.1056/NEJMoa1508952
PG 11
WC Medicine, General & Internal
SC General & Internal Medicine
GA EB2RP
UT WOS:000387209900005
PM 27192360
ER
PT J
AU Piccinini, N
Lambert, D
West, BJ
Bologna, M
Grigolini, P
AF Piccinini, Nicola
Lambert, David
West, Bruce J.
Bologna, Mauro
Grigolini, Paolo
TI Nonergodic complexity management
SO PHYSICAL REVIEW E
LA English
DT Article
ID HUMAN COGNITION; 1/F NOISE; CRITICALITY; INFORMATION; NETWORKS;
INTERMITTENCY; AVALANCHES; EMERGENCE; BREAKDOWN; DYNAMICS
AB Linear response theory, the backbone of nonequilibrium statistical physics, has recently been extended to explain how and why nonergodic renewal processes are insensitive to simple perturbations, such as in habituation. It was established that a permanent correlation results between an external stimulus and the response of a complex system generating nonergodic renewal processes, when the stimulus is a similar nonergodic process. This is the principle of complexity management, whose proof relies on ensemble distribution functions. Herein we extend the proof to the nonergodic case using time averages and a single time series, hence making it usable in real life situations where ensemble averages cannot be performed because of the very nature of the complex systems being studied.
C1 [Piccinini, Nicola; Lambert, David; Grigolini, Paolo] Univ N Texas, Ctr Nonlinear Sci, POB 311427, Denton, TX 76203 USA.
[West, Bruce J.] US Army, Informat Sci Directorate, Res Off, Res Triangle Pk, NC 27709 USA.
[Bologna, Mauro] Univ Tarapaca, Inst Alta Invest, Casilla 6-D, Arica, Chile.
RP Piccinini, N (reprint author), Univ N Texas, Ctr Nonlinear Sci, POB 311427, Denton, TX 76203 USA.
FU Welch Foundation [B-1577]; Army Research Office [W911NF-15-1-0245]
FX N.P., D.L., and G.P. thank Welch Foundation for financial support
through Grant No. B-1577 and Army Research Office for financial support
through Grant No. W911NF-15-1-0245.
NR 53
TC 1
Z9 1
U1 3
U2 5
PU AMER PHYSICAL SOC
PI COLLEGE PK
PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA
SN 2470-0045
EI 2470-0053
J9 PHYS REV E
JI Phys. Rev. E
PD JUN 2
PY 2016
VL 93
IS 6
AR 062301
DI 10.1103/PhysRevE.93.062301
PG 7
WC Physics, Fluids & Plasmas; Physics, Mathematical
SC Physics
GA DN3ZA
UT WOS:000377001600003
PM 27415274
ER
PT J
AU Yu, AB
Zacks, JM
AF Yu, Alfred B.
Zacks, Jeffrey M.
TI How are bodies special? Effects of body features on spatial reasoning
SO QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY
LA English
DT Article
DE Perspective taking; Spatial transformations; Mental imagery
ID MENTAL ROTATION; INVERSION; TRANSFORMATIONS; PERCEPTION; FACE;
MOVEMENTS; OBJECTS; AREA
AB Embodied views of cognition argue that cognitive processes are influenced by bodily experience. This implies that when people make spatial judgments about human bodies, they bring to bear embodied knowledge that affects spatial reasoning performance. Here, we examined the specific contribution to spatial reasoning of visual features associated with the human body. We used two different tasks to elicit distinct visuospatial transformations: object-based transformations, as elicited in typical mental rotation tasks, and perspective transformations, used in tasks in which people deliberately adopt the egocentric perspective of another person. Body features facilitated performance in both tasks. This result suggests that observers are particularly sensitive to the presence of a human head and body, and that these features allow observers to quickly recognize and encode the spatial configuration of a figure. Contrary to prior reports, this facilitation was not related to the transformation component of task performance. These results suggest that body features facilitate task components other than spatial transformation, including the encoding of stimulus orientation.
C1 [Yu, Alfred B.] Army Res Lab, Aberdeen Proving Ground, MD USA.
[Yu, Alfred B.; Zacks, Jeffrey M.] Washington Univ, Dept Psychol, 1 Brookings Dr, St Louis, MO 63130 USA.
RP Zacks, JM (reprint author), Washington Univ, Dept Psychol, 1 Brookings Dr, St Louis, MO 63130 USA.
EM jzacks@wustl.edu
FU United States Department of Defense Science, Mathematics, and Research
for Transformation (SMART) scholarship; NIMH [RO1MH70674]; NIA
[R01AG031150]
FX This work was supported by a United States Department of Defense
Science, Mathematics, and Research for Transformation (SMART)
scholarship to the first author, and NIMH grant [grant number
RO1MH70674] and a NIA grant [grant number R01AG031150] to the second
author.
NR 31
TC 0
Z9 0
U1 2
U2 14
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1747-0218
EI 1747-0226
J9 Q J EXP PSYCHOL
JI Q. J. Exp. Psychol.
PD JUN 2
PY 2016
VL 69
IS 6
BP 1210
EP 1226
DI 10.1080/17470218.2015.1079225
PG 17
WC Psychology, Biological; Physiology; Psychology; Psychology, Experimental
SC Psychology; Physiology
GA DG6GR
UT WOS:000372182300014
PM 26252072
ER
PT J
AU Houston, MN
Hoch, MC
Hoch, JM
AF Houston, Megan N.
Hoch, Matthew C.
Hoch, Johanna M.
TI Health-Related Quality of Life in Athletes: A Systematic Review With
Meta-Analysis
SO JOURNAL OF ATHLETIC TRAINING
LA English
DT Review
DE patient-centered care; patient outcomes; athletic injuries
ID PHYSICAL-ACTIVITY; OUTCOMES RESEARCH; POPULATION; VALIDITY; INJURY;
SF-36; CHILDREN; CLINICIAN; BENEFITS; FITNESS
AB Context: Assessment of health-related quality of life (HRQOL) after injury is important. Differences in HRQOL between nonathletes and athletes and between injured and uninjured athletes have been demonstrated; however, the evidence has not been synthesized.
Objective: To answer the following questions: (1) Does HRQOL differ among adolescent and collegiate athletes and nonathletes? (2) Does HRQOL differ between injured adolescent and collegiate athletes or between athletes with a history of injury and uninjured athletes or those without a history of injury?
Data Sources: We systematically searched CINAHL, MEDLINE, SPORTDiscus, and PubMed. A hand search of references was also conducted.
Study Selection: Studies were included if they used generic instruments to compare HRQOL outcomes between athletes and nonathletes and between uninjured and injured athletes. Studies were excluded if they did not use a generic instrument, pertained to instrument development, or included retired athletes or athletes with a chronic disease.
Data Extraction: We assessed study quality using the modified Downs and Black Index Tool. Bias-corrected Hedges g effect sizes and 95% confidence intervals (CIs) were calculated. The Strength of Recommendation Taxonomy (SORT) was used to determine the overall strength of the recommendation. A random-effects meta-analysis was performed for all studies using the composite or total score.
Data Synthesis: Eight studies with modified Downs and Black scores ranging from 70.6% to 88.4% were included. For question 1, the overall random-effects meta-analysis was weak (effect size = 0.27, 95% confidence interval = 0.14, 0.40; P < .001). For question 2, the overall random-effects meta-analysis was moderate (effect size = 0.68, 95% confidence interval = 0.42, 0.95; P < .001).
Conclusions: Grade A evidence indicates that athletes reported better HRQOL than nonathletes and that uninjured athletes reported better HRQOL than injured athletes. However, the overall effect for question 1 was weak, suggesting that the differences between athletes and nonathletes may not be clinically meaningful. Clinicians should monitor HRQOL after injury to ensure that all dimensions of health are appropriately treated.
C1 [Houston, Megan N.] Keller Army Community Hosp, 900 Washington Rd, West Point, NY 10996 USA.
[Hoch, Matthew C.; Hoch, Johanna M.] Old Dominion Univ, Norfolk, VA USA.
RP Houston, MN (reprint author), Keller Army Community Hosp, 900 Washington Rd, West Point, NY 10996 USA.
EM megan.n.houston.ctr@mail.mil
NR 41
TC 0
Z9 0
U1 1
U2 1
PU NATL ATHLETIC TRAINERS ASSOC INC
PI DALLAS
PA 2952 STEMMONS FREEWAY, DALLAS, TX 75247 USA
SN 1062-6050
EI 1938-162X
J9 J ATHL TRAINING
JI J. Athl. Train.
PD JUN
PY 2016
VL 51
IS 6
BP 442
EP 453
DI 10.4085/1062-6050-51.7.03
PG 12
WC Sport Sciences
SC Sport Sciences
GA EI9VI
UT WOS:000392857100003
PM 27258942
ER
PT J
AU Forney, AJ
AF Forney, Andrew J.
TI Radical Rhetoric, Conservative Goals: The Democratic Society of Kentucky
and the Language of Transatlantic Radicalism in the 1790s
SO REGISTER OF THE KENTUCKY HISTORICAL SOCIETY
LA English
DT Article
C1 [Forney, Andrew J.] Christian Univ, Armys Capabil Integrat Ctr, Bengaluru, Karnataka, India.
[Forney, Andrew J.] US Mil Acad, West Point, NY 10996 USA.
RP Forney, AJ (reprint author), Christian Univ, Armys Capabil Integrat Ctr, Bengaluru, Karnataka, India.; Forney, AJ (reprint author), US Mil Acad, West Point, NY 10996 USA.
NR 63
TC 0
Z9 0
U1 0
U2 0
PU KENTUCKY HISTORICAL SOC
PI FRANKFORT
PA 100 W BROADWAY, FRANKFORT, KY 40601 USA
SN 0023-0243
EI 2161-0355
J9 REGIST KY HIST SOC
JI Regist. Ky. Hist. Soc.
PD SUM-FAL
PY 2016
VL 114
IS 3-4
BP 431
EP 460
DI 10.1353/khs.2016.0067
PG 30
WC History
SC History
GA EI0VZ
UT WOS:000392194500006
ER
PT J
AU Estrada, AX
Severt, JB
Jimenez-Rodriguez, M
AF Estrada, Armando X.
Severt, Jamie B.
Jimenez-Rodriguez, Miliani
TI Elaborating on the Conceptual Underpinnings of Resilience
SO INDUSTRIAL AND ORGANIZATIONAL PSYCHOLOGY-PERSPECTIVES ON SCIENCE AND
PRACTICE
LA English
DT Editorial Material
AB The term resilience has grown in popularity among the general public and within the scientific community. Unfortunately, the rise in popularity has advanced neither our theoretical understanding of this construct nor the methodological approaches to study this topic. Britt, Shen, Sinclair, Grossman, and Klieger (2016) highlighted important conceptual, methodological, and practical advances and shortcomings within the literature on employee resilience. However, critical conceptual issues remain unaddressed within the focal article. Specifically, in our commentary, we differentiate between resiliency and resilience, identify key dimensions of each construct, and explicate the role of adversity and context to further advance our theoretical understanding of this construct. We conclude by discussing the implications of our proposed conceptualization and refinement of resilience for theory, research, and practice.
C1 [Estrada, Armando X.] US Army Res Inst Behav & Social Sci, Foundat Sci Res Unit, Aberdeen, MD USA.
[Severt, Jamie B.] George Washington Univ, Dept Org Sci & Commun, Washington, DC 20052 USA.
[Jimenez-Rodriguez, Miliani] US Army Res Inst Behav & Social Sci, Leader Dev Res Unit, Ft Leavenworth, KS USA.
RP Estrada, AX (reprint author), US Army Res Inst Behav & Social Sci, Foundat Sci Res Unit, Aberdeen, MD USA.
EM armando.x.estrada@gmail.com
NR 12
TC 0
Z9 0
U1 0
U2 0
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1754-9426
EI 1754-9434
J9 IND ORGAN PSYCHOL-US
JI Ind. Organ. Psychol.
PD JUN
PY 2016
VL 9
IS 2
BP 497
EP 502
DI 10.1017/iop.2016.46
PG 6
WC Psychology, Applied
SC Psychology
GA DV4FM
UT WOS:000382880800042
ER
PT J
AU Fiske, LC
Homeyer, DC
Zapor, M
Hartzell, J
Warkentien, T
Weintrob, AC
Ganesan, A
Burgess, T
Snesrud, E
Waterman, P
Nielsen, L
Ressner, RA
AF Fiske, Lauren C.
Homeyer, Diane C.
Zapor, Michael
Hartzell, Joshua
Warkentien, Tyler
Weintrob, Amy C.
Ganesan, Anuradha
Burgess, Timothy
Snesrud, Erik
Waterman, Paige
Nielsen, Lindsey
Ressner, Roseanne A.
TI Isolation of Rapidly Growing Nontuberculous Mycobacteria in Wounds
Following Combat-Related Injury
SO MILITARY MEDICINE
LA English
DT Article
ID INFECTION; ABSCESSUS; SKIN; DISEASE; RESISTANCE; CHELONAE
AB Objectives: Rapidly growing nontuberculous mycobacteria (RGNTM) have yet to be described in combatrelated injuries. This study investigates the epidemiology, clinical findings, treatment, and outcomes of RGNTM infections among combat casualties wounded in Afghanistan from 2010 to 2012. Methods: Patients with RGNTM were identified from the Department of Defense Trauma Registry through the Trauma Infectious Disease Outcomes Study. Trauma history, surgical management, and clinical data were collected. Six isolates from patients requiring antimycobacterial therapy were sequenced. Results: Seventeen cases were identified. Six cases, predominantly associated with Mycobacterium abscessus, required aggressive debridement and a median of 180 days of multidrug antimycobacterial therapy that included clofazimine. M. abscessus isolates expressed the erythromycin resistance methylase (erm(41)) gene for inducible macrolide resistance, yet there were no clinical treatment failures when macrolides were utilized in combination therapy. No clonal similarity between M. abscessus isolates was found. Eleven cases had positive wound cultures, but did not require antimycobacterial therapy. The median duration of time of injury to first detection of a RGNTM was 57 days. Conclusions: This represents the first report of RGNTM infections in war-wounded patients. RGNTM should be recognized as potential pathogens in grossly infected combat wounds. Surgical debridement and multidrug antimycobacterial therapy, when clinically indicated, was associated with satisfactory clinical outcomes.
C1 [Fiske, Lauren C.; Zapor, Michael; Hartzell, Joshua; Warkentien, Tyler; Weintrob, Amy C.; Ganesan, Anuradha; Burgess, Timothy; Ressner, Roseanne A.] Walter Reed Natl Mil Med Ctr, 8901 Wisconsin Ave, Bethesda, MD 20889 USA.
[Homeyer, Diane C.] San Antonio Mil Med Ctr, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
[Hartzell, Joshua; Burgess, Timothy; Waterman, Paige; Nielsen, Lindsey; Ressner, Roseanne A.] Uniformed Serv Univ Hlth Sci, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
[Weintrob, Amy C.; Ganesan, Anuradha] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
[Snesrud, Erik; Waterman, Paige; Nielsen, Lindsey] Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
RP Fiske, LC (reprint author), Walter Reed Natl Mil Med Ctr, 8901 Wisconsin Ave, Bethesda, MD 20889 USA.
FU Infectious Disease Clinical Research Program Trauma Infectious Diseases
Outcomes Study team
FX We thank the Infectious Disease Clinical Research Program Trauma
Infectious Diseases Outcomes Study team for their support in this
project.
NR 21
TC 0
Z9 0
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD JUN
PY 2016
VL 181
IS 6
BP 530
EP 536
DI 10.7205/MILMED-D-14-00731
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA DW5LO
UT WOS:000383686900011
PM 27244062
ER
PT J
AU Escolas, HD
Ray, LN
Escolas, SM
AF Escolas, Hollie D.
Ray, Lashawnna N.
Escolas, Sandra M.
TI Personality Traits and Family Styles of Combat Medics in Training
SO MILITARY MEDICINE
LA English
DT Article
ID CIRCUMPLEX MODEL; 5-FACTOR MODEL; LIFE-COURSE; SYSTEMS
AB This descriptive study examines the relationship between four family types and five personality traits. The four family types are balanced, moderately balanced, midrange, and extreme. The five personality traits are extraversion, openness to experiences, agreeableness, emotional stability, and conscientiousness. Data were collected through anonymous questionnaires distributed to combat-naive Soldiers at the beginning of their advanced individual training. This study utilized the Family Adaptability and Cohesion Evaluation Scale(1) and the Ten-Item Personality Inventory(2) as measures. Overall the analyses found that participants classified as a balanced family type scored significantly higher on the personality traits of extraversion, agreeableness, and openness to experience than those classified in the family types of extreme, midrange, and moderately balanced. It appears that family types are associated with personality traits. This study opens doors to future research including looking at how family and personality types relate to each other in military units and personnel.
C1 [Escolas, Hollie D.] Univ Texas San Antonio, Downtown Campus,501 West Cesar E Chavez Blvd, San Antonio, TX 78207 USA.
[Escolas, Hollie D.] Oak Ridge Inst Sci & Educ, Maryland Off, 4692 Millennium Dr, Belcamp, MD 21017 USA.
[Ray, Lashawnna N.; Escolas, Sandra M.] US Army, Joint Base Lewis McChord, Med Res Directorate West, Tacoma, WA 98433 USA.
RP Escolas, HD (reprint author), Univ Texas San Antonio, Downtown Campus,501 West Cesar E Chavez Blvd, San Antonio, TX 78207 USA.; Escolas, HD (reprint author), Oak Ridge Inst Sci & Educ, Maryland Off, 4692 Millennium Dr, Belcamp, MD 21017 USA.
FU Department of Defense, Defense Medical Research and Development Program
[FY2010]; U.S. Department of Energy; U.S. Army Medical Research and
Materiel Command
FX We wish to acknowledge the contributions of Rachel Arata-Maiers. Her
initial draft provided a great starting point to this article. Funding
for this project came from a Department of Defense, Defense Medical
Research and Development Program, FY2010 Basic Research Award. This
research was supported in part by an appointment to the Student Research
participation Program at the U.S. Army Institute of Surgical Research
administered by the Oak Ridge Institute for Science and Education
through an interagency agreement between the U.S. Department of Energy
andU.S. Army Medical Research and Materiel Command.
NR 22
TC 0
Z9 0
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD JUN
PY 2016
VL 181
IS 6
BP 546
EP 552
DI 10.7205/MILMED-D-15-00165
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA DW5LO
UT WOS:000383686900013
PM 27244064
ER
PT J
AU Allen, CJ
Straker, RJ
Murray, CR
Hannay, WM
Hanna, MM
Meizoso, JP
Manning, RJ
Schulman, CI
Seery, JM
Proctor, KG
AF Allen, Casey J.
Straker, Richard J.
Murray, Clark R.
Hannay, William M.
Hanna, Mena M.
Meizoso, Jonathan P.
Manning, Ronald J.
Schulman, Carl I.
Seery, Jason M.
Proctor, Kenneth G.
TI Recent Advances in Forward Surgical Team Training at the US Army Trauma
Training Department
SO MILITARY MEDICINE
LA English
DT Article
ID MASS CASUALTY; IMPROVES; CARE
AB U.S. Army Forward Surgical Teams (FSTs) are elite, multidisciplinary units that are highly mobile, and rapidly deployable. The mission of the FST is to provide resuscitative and damage control surgery for stabilization of life-threatening injuries in austere environments. The Army Trauma Training Center began in 2001 at the University of Miami Ryder Trauma Center under the direction of COL T.E. Knuth, MC USA (Ret.), as a multimodality combination of lectures, laboratory exercises, and clinical experiences that provided the only predeployment mass casualty and clinical trauma training center for all FSTs. Each of the subsequent five directors has restructured the training based on dynamic feedback from trainees, current military needs, and on the rapid advances in combat casualty care. We have highlighted these evolutionary changes at the Army Trauma Training Center in previous reviews. Under the current director, LTC J.M. Seery, MC USA, there are new team-building exercises, mobile learning modules and simulators, and other alternative methods in the mass casualty exercise. This report summarizes the latest updates to the state of the art training since the last review.
C1 [Allen, Casey J.; Straker, Richard J.; Murray, Clark R.; Hannay, William M.; Hanna, Mena M.; Meizoso, Jonathan P.; Manning, Ronald J.; Schulman, Carl I.; Seery, Jason M.; Proctor, Kenneth G.] Univ Miami, Miller Sch Med, Dewitt Daughtry Dept Surg, Ryder Trauma Ctr,Div Trauma, 1800 NW 10th Ave, Miami, FL 33136 USA.
[Allen, Casey J.; Straker, Richard J.; Murray, Clark R.; Hannay, William M.; Hanna, Mena M.; Meizoso, Jonathan P.; Manning, Ronald J.; Schulman, Carl I.; Seery, Jason M.; Proctor, Kenneth G.] Univ Miami, Miller Sch Med, Dewitt Daughtry Dept Surg, Ryder Trauma Ctr,Div Surg Crit Care, 1800 NW 10th Ave, Miami, FL 33136 USA.
[Schulman, Carl I.; Seery, Jason M.; Proctor, Kenneth G.] Univ Miami, Miller Sch Med, US Army, Trauma Training Dept,Ryder Trauma Ctr, 1800 NW 10th Ave, Miami, FL 33136 USA.
RP Allen, CJ (reprint author), Univ Miami, Miller Sch Med, Dewitt Daughtry Dept Surg, Ryder Trauma Ctr,Div Trauma, 1800 NW 10th Ave, Miami, FL 33136 USA.; Allen, CJ (reprint author), Univ Miami, Miller Sch Med, Dewitt Daughtry Dept Surg, Ryder Trauma Ctr,Div Surg Crit Care, 1800 NW 10th Ave, Miami, FL 33136 USA.
FU Office of Naval Research [N140610670]; U.S. Army Medical Research and
Materiel Command [09078015]
FX The successful operation of the FST training at the ATTD described in
this article has literally involved hundreds of faculty, staff,
students, and volunteers. We thank them for their continued efforts for
the betterment of the program. This study was supported by the grants
no. N140610670 from the Office of Naval Research and no. 09078015 from
U.S. Army Medical Research and Materiel Command.
NR 10
TC 0
Z9 0
U1 1
U2 2
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD JUN
PY 2016
VL 181
IS 6
BP 553
EP 559
DI 10.7205/MILMED-D-15-00084
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA DW5LO
UT WOS:000383686900014
PM 27244065
ER
PT J
AU Stoddard, DR
Robinson, AB
Comer, TA
Meno, JA
Welder, MD
AF Stoddard, Douglas R.
Robinson, Andrew B.
Comer, Tracy A.
Meno, Jenifer A.
Welder, Matthew D.
TI A Surgical Business Composite Score for Army Medicine
SO MILITARY MEDICINE
LA English
DT Article
ID INDICATORS
AB Measuring surgical business performance for Army military treatment facilities is currently done through 6 business metrics developed by the Army Medical Command (MEDCOM) Surgical Services Service Line (3SL). Development of a composite score for business performance has the potential to simplify and synthesize measurement, improving focus for strategic goal setting and implementation. However, several considerations, ranging from data availability to submetric selection, must be addressed to ensure the score is accurate and representative. This article presents the methodology used in the composite score's creation and presents a metric based on return on investment and a measure of cases recaptured from private networks.
C1 [Stoddard, Douglas R.] Madigan Army Med Ctr, 9040 Jackson Ave, Tacoma, WA 98431 USA.
[Robinson, Andrew B.; Comer, Tracy A.; Meno, Jenifer A.; Welder, Matthew D.] US Army, Off Surg Gen, Med Command, 7700 Arlington Blvd, Falls Church, VA 22032 USA.
RP Stoddard, DR (reprint author), Madigan Army Med Ctr, 9040 Jackson Ave, Tacoma, WA 98431 USA.
NR 10
TC 0
Z9 0
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD JUN
PY 2016
VL 181
IS 6
BP 567
EP 571
DI 10.7205/MILMED-D-14-00701
PG 5
WC Medicine, General & Internal
SC General & Internal Medicine
GA DW5LO
UT WOS:000383686900016
PM 27244067
ER
PT J
AU Cole, RE
Clark, HL
Heileson, J
DeMay, J
Smith, MA
AF Cole, Renee E.
Clark, Heidi L.
Heileson, Jeffery
DeMay, Jordan
Smith, Martha A.
TI Normal Weight Status in Military Service Members Was Associated With
Intuitive Eating Characteristic
SO MILITARY MEDICINE
LA English
DT Article
ID BODY-MASS INDEX; PSYCHOMETRIC EVALUATION; PHYSICAL-ACTIVITY;
UNITED-STATES; OBESITY; BEHAVIORS; HEALTH; MOTIVATION; EXERCISE; ADULTS
AB The purpose of this study was to determine the relationship between individual weight status and intuitive eating or motivation for eating characteristics. Participants were predominantly white (57%), Army (91%), enlisted (72%), males (71%), with a mean age of 30 +/- 9 years and mean body mass index (BMI) of 27.0 +/- 4.2 kg/m(2). The cross-sectional, descriptive study included active duty service members (n = 295) recruited from Texas and Washington. Validated Motivation for Eating Scale (MFES) and Intuitive Eating Scale were administered and BMI (m/kg(2)) was dichotomized at <25 or = 25 kg/m(2). Descriptive, correlation, t-test, and logistic regression analysis were conducted for BMI category with demographic, lifestyle, and MFES/Intuitive Eating Scale scores (a = 0.05; 80% power). Thirty-six percent were normal BMI (22.7 +/- 1.6 kg/m(2)) and 64% were overweight/ obese BMI (29.3 +/- 3.3 kg/m(2)). Mean BMI was 27.8 +/- 4.2 kg/m(2) (males) and 24.8 +/- 3.4 kg/m(2) (females) (p < 0.001). Physical MFES type was predominant (77% normal BMI vs. 66% overweight; p = 0.001). Males ate for physical rather than emotional reasons (p = 0.014). Each 1-point increase in Reliance on Internal Hunger Satiety Score was associated with 34% lower odds of being overweight. Disparity existed between sex and intuitive eating characteristic. Increasing awareness of eating influences may improve weight-related dietary behaviors.
C1 [Cole, Renee E.] US Army, Environm Med Res Inst, 15 Kansas St, Natick, MA 01760 USA.
[Clark, Heidi L.] US Air Force, Joint Base San Antonio Lackland, 59th Med Wing,1701 Kenly Ave, San Antonio, TX 78236 USA.
[Heileson, Jeffery] Blanchfield Army Community Hosp, Nutr Care Div, 650 Joel Dr, Ft Campbell, KY 42223 USA.
[DeMay, Jordan] Moncrief Army Community Hosp, Nutr Care Div, 4500 Stuart St, Ft Jackson, SC 29207 USA.
[Smith, Martha A.] Brian Allgood Army Community Hosp, 19 Hangangno Dong, Yongsan, South Korea.
RP Cole, RE (reprint author), US Army, Environm Med Res Inst, 15 Kansas St, Natick, MA 01760 USA.
NR 44
TC 0
Z9 0
U1 2
U2 2
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD JUN
PY 2016
VL 181
IS 6
BP 589
EP 595
DI 10.7205/MILMED-D-15-00250
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA DW5LO
UT WOS:000383686900020
PM 27244071
ER
PT J
AU Hilber, DJ
AF Hilber, David J.
TI Binocular Visual Acuity and Corrective Lens Use in the United States
Army
SO MILITARY MEDICINE
LA English
DT Article
ID REFRACTIVE ERROR; IMPAIRMENT; PREVALENCE; POPULATION; BLINDNESS; EYE
AB Purpose: To assess uncorrected and corrected distance and near binocular visual acuity (VA) and the use of corrective lenses in U.S. Army Active Duty, Guard, and Reserve Soldiers. Methods: A descriptive statistical analysis of VA group data from the U.S. Army Vision Readiness Classification Screening system was performed. Data pulls from June 2012 to January 2015 were compared. Results: In January 2015, 62.3% of Soldiers had an uncorrected binocular distance VA of 20/20, 21.2% of Soldiers were worse than 20/40, and 41.4% of Soldiers wore corrective eyewear for distance vision. With correction, 92.5% had a binocular distance VA of 20/20 and 1.4% were worse than 20/40. In January 2015, 32.6% of Soldiers age > 45 had an uncorrected binocular near VA of 20/20, 28.4% of Soldiers age > 45 were worse than 20/40, and 61.9% of Soldiers age > 45 wore corrective eyewear for near vision. With correction, 74.6% had a binocular near VA of 20/20 and 3.0% were worse than 20/40. Data for both years were similar, although there were differences between individual service components. Conclusions: In comparison to the U.S. adult population, U.S. Army Soldiers have better uncorrected and corrected vision and are less likely to wear vision correction.
C1 [Hilber, David J.] US Army, Publ Hlth Command, Triserv Vis Conservat & Readiness Program, Oak Ridge Inst Sci & Educ Knowledge Management Co, 5158 Blackhawk Rd, Gunpowder, MD 21010 USA.
RP Hilber, DJ (reprint author), US Army, Publ Hlth Command, Triserv Vis Conservat & Readiness Program, Oak Ridge Inst Sci & Educ Knowledge Management Co, 5158 Blackhawk Rd, Gunpowder, MD 21010 USA.
NR 8
TC 0
Z9 0
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD JUN
PY 2016
VL 181
IS 6
BP 602
EP 608
DI 10.7205/MILMED-D-15-00261
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA DW5LO
UT WOS:000383686900022
PM 27244073
ER
PT J
AU Criman, ET
Kurata, WE
Matsumoto, KW
Aubin, HT
Campbell, CE
Pierce, LM
AF Criman, Erik T.
Kurata, Wendy E.
Matsumoto, Karen W.
Aubin, Harry T.
Campbell, Carmen E.
Pierce, Lisa M.
TI Bone Marrow-Derived Mesenchymal Stem Cells Enhance Bacterial Clearance
and Preserve Bioprosthetic Integrity in a Model of Mesh Infection
SO PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN
LA English
DT Article
ID VENTRAL HERNIA REPAIR; RANDOMIZED CONTROLLED-TRIAL; ACELLULAR DERMAL
MATRICES; TERM-FOLLOW-UP; INCISIONAL HERNIA; POLYPROPYLENE MESH;
ESCHERICHIA-COLI; SYNTHETIC MESHES; BIOLOGIC MESHES; COLONIZATION
AB Background: The reported incidence of mesh infection in contaminated operative fields is as high as 30% regardless of the material used. Recently, mesenchymal stem cells (MSCs) have been shown to possess favorable immunomodulatory properties and improve tissue incorporation when seeded onto bioprosthetics. The aim of this study was to evaluate whether seeding noncrosslinked bovine pericardium (Veritas Collagen Matrix) with allogeneic bone marrow-derived MSCs improves infection resistance in vivo after inoculation with Escherichia coli (E. coli).
Methods: Rat bone marrow-derived MSCs at passage 3 were seeded onto bovine pericardium and cultured for 7 days before implantation. Additional rats (n = 24) were implanted subcutaneously with MSC-seeded or unseeded mesh and inoculated with 7 x 10(5) colony-forming units of E. coli or saline before wound closure (group 1, unseeded mesh/saline; group 2, unseeded mesh/E. coli; group 3, MSC-seeded mesh/E. coli; 8 rats per group). Meshes were explanted at 4 weeks and underwent microbiologic and histologic analyses.
Results: MSC-seeded meshes inoculated with E. coli demonstrated superior bacterial clearance and preservation of mesh integrity compared with E. coli-inoculated unseeded meshes (87.5% versus 0% clearance; p = 0.001). Complete mesh degradation concurrent with abscess formation was observed in 100% of rats in the unseeded/E. coli group, which is in contrast to 12.5% of rats in the MSC-seeded/E. coli group. Histologic evaluation determined that remodeling characteristics of E. coli-inoculated MSC-seeded meshes were similar to those of uninfected meshes 4 weeks after implantation.
Conclusions: Augmenting a bioprosthetic material with stem cells seems to markedly enhance resistance to bacterial infection in vivo and preserve mesh integrity.
C1 [Criman, Erik T.; Aubin, Harry T.] Tripler Army Med Ctr, Dept Gen Surg, Honolulu, HI 96859 USA.
[Kurata, Wendy E.; Matsumoto, Karen W.; Campbell, Carmen E.; Pierce, Lisa M.] Tripler Army Med Ctr, Dept Clin Invest, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
RP Pierce, LM (reprint author), Tripler Army Med Ctr, Dept Clin Invest, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM lisa.m.pierce.civ@mail.mil
NR 41
TC 0
Z9 0
U1 3
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2169-7574
J9 PRS-GLOB OPEN
JI PRS-GLOB. OPEN
PD JUN
PY 2016
VL 4
IS 6
AR e751
DI 10.1097/GOX.0000000000000765
PG 8
WC Surgery
SC Surgery
GA EC7ZG
UT WOS:000388359100018
PM 27482490
ER
PT J
AU Ploumis, M
Pilalis, LE
AF Ploumis, Michail
Pilalis, Labros E.
TI A New Deal for the Middle East and North Africa
SO MEDITERRANEAN QUARTERLY-A JOURNAL OF GLOBAL ISSUES
LA English
DT Article
C1 [Ploumis, Michail] Hellen Army, Harare, Zimbabwe.
[Ploumis, Michail] Int Assistance Force Afghanistan, Kabul, Afghanistan.
[Ploumis, Michail] US Army, War Coll, Carlisle, PA 17013 USA.
[Ploumis, Michail] Univ Peloponnese, Econ, Tripoli, Libya.
[Pilalis, Labros E.] Penn Publ Util Commiss, Harrisburg, PA USA.
[Pilalis, Labros E.] Indiana Univ, Sch Law Indianapolis, Doctorate Jurisprudence, Bloomington, IN 47405 USA.
RP Ploumis, M (reprint author), Hellen Army, Harare, Zimbabwe.; Ploumis, M (reprint author), Int Assistance Force Afghanistan, Kabul, Afghanistan.; Ploumis, M (reprint author), US Army, War Coll, Carlisle, PA 17013 USA.; Ploumis, M (reprint author), Univ Peloponnese, Econ, Tripoli, Libya.
NR 30
TC 0
Z9 0
U1 1
U2 1
PU DUKE UNIV PRESS
PI DURHAM
PA 905 W MAIN ST, STE 18-B, DURHAM, NC 27701 USA
SN 1047-4552
EI 1527-1935
J9 MEDITERR Q
JI Mediterr. Q.
PD JUN
PY 2016
VL 27
IS 2
BP 89
EP 100
DI 10.1215/10474552-3618083
PG 12
WC International Relations
SC International Relations
GA DZ1PU
UT WOS:000385611100006
ER
PT J
AU Rodriguez, LC
AF Rodriguez, Ludrena C.
TI Maternal-Child Health Simulation Drills
SO JOGNN-JOURNAL OF OBSTETRIC GYNECOLOGIC AND NEONATAL NURSING
LA English
DT Meeting Abstract
DE simulation drills; maternal-child health; labor and delivery; postpartum
C1 [Rodriguez, Ludrena C.] Tripler Army Med Ctr, Mililani, HI USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0884-2175
EI 1552-6909
J9 JOGNN-J OBST GYN NEO
JI JOGNN
PD JUN
PY 2016
VL 45
IS 3
SU S
BP S16
EP S16
PG 1
WC Nursing; Obstetrics & Gynecology
SC Nursing; Obstetrics & Gynecology
GA DY3NH
UT WOS:000385000000032
ER
PT J
AU Tess, M
Kurman, M
Kweon, CB
AF Tess, Michael
Kurman, Matthew
Kweon, Chol-Bum
TI Spray Characterization and Ignition Delay Measurements of JP-8 and IPK
in a Constant-Pressure Flow Chamber
SO SAE INTERNATIONAL JOURNAL OF ENGINES
LA English
DT Article
ID FUELS; COMBUSTION; ENGINES
AB This research compares the spray development and combustion characteristics of jet propellant 8 (JP-8) and iso-paraffinic kerosene (IPK) through a range of diesel engine in-cylinder operating conditions. Non-reacting spray experiments were performed in a constant-pressure flow chamber with 99% nitrogen gas composition at constant temperature (900 K) and densities ranging from 11-56 kg/m(3). Near-simultaneous, high-speed Mie and schlieren images of the spray were acquired to measure the liquid and vapor penetration lengths of the non-reacting jet. Reacting experiments, consisting of photodiode measurements and intensified high-speed movies of OH* chemiluminescence, were performed at the same thermodynamic conditions as the non-reacting experiments, except with a 21%/79% oxygen/nitrogen ambient gas composition. Measurements of the rate of injection, issued from a single-hole axial common-rail fuel injector, showed negligible differences between the fuels. The non-reacting liquid length of IPK was approximately 20% shorter than JP-8 for the range of tested conditions, which was consistent with the average difference in volatility between the fuels. The ignition delay, determined from the photodiode record, was up to 80% longer for IPK fuel at low density conditions. Additionally, the lift-off length of IPK was measured to be approximately 50% more sensitive to ambient pressure than JP-8. These results provide fundamental information for the calibration and optimization of military diesel engines operating on conventional and alternatively sourced jet fuels.
C1 [Tess, Michael; Kurman, Matthew; Kweon, Chol-Bum] US Army, Res Lab, Adelphi, MD 20783 USA.
RP Tess, M (reprint author), US Army, Res Lab, Adelphi, MD 20783 USA.
EM michael.j.tess@mail.mil
NR 37
TC 0
Z9 0
U1 2
U2 2
PU SAE INT
PI WARRENDALE
PA 400 COMMONWEALTH DR, WARRENDALE, PA 15096 USA
SN 1946-3936
EI 1946-3944
J9 SAE INT J ENGINES
JI SAE Int. J. Engines
PD JUN
PY 2016
VL 9
IS 2
BP 899
EP 909
DI 10.4271/2016-01-0736
PG 11
WC Transportation Science & Technology
SC Transportation
GA DX9JJ
UT WOS:000384710600021
ER
PT J
AU Zabecki, DT
AF Zabecki, David T.
TI Battlefield Fulda gap
SO JOURNAL OF COLD WAR STUDIES
LA English
DT Book Review
C1 [Zabecki, David T.] US Army, Washington, DC 20319 USA.
RP Zabecki, DT (reprint author), US Army, Washington, DC 20319 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU MIT PRESS
PI CAMBRIDGE
PA ONE ROGERS ST, CAMBRIDGE, MA 02142-1209 USA
SN 1520-3972
EI 1531-3298
J9 J COLD WAR STUD
JI J. Cold War Stud.
PD SUM
PY 2016
VL 18
IS 3
BP 222
EP 225
DI 10.1162/JCWS_r_00667
PG 4
WC History; International Relations; Political Science
SC History; International Relations; Government & Law
GA DW9QJ
UT WOS:000383996400025
ER
PT J
AU Mulligan, RP
Hanson, JL
AF Mulligan, Ryan P.
Hanson, Jeffrey L.
TI Alongshore momentum transfer to the nearshore zone from energetic ocean
waves generated by passing hurricanes
SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS
LA English
DT Article
ID LONGSHORE CURRENTS; SHEAR INSTABILITIES; TROPICAL CYCLONES; DRAG
COEFFICIENT; SURF ZONE; BREAKING; BEACH; STORM; MODEL
AB Wave and current measurements from a cross-shore array of nearshore sensors in Duck, NC, are used to elucidate the balance of alongshore momentum under energetic wave conditions with wide surf zones, generated by passing hurricanes that are close to and far from to the coast. The observations indicate that a distant storm (Hurricane Bill, 2009) with large waves has low variability in directional wave characteristics resulting in alongshore currents that are driven mainly by the changes in wave energy. A storm close to the coast (Hurricane Earl, 2010), with strong local wind stress and combined sea and swell components in wave energy spectra, has high variability in wave direction and wave period that influence wave breaking and nearshore circulation as the storm passes. During both large wave events, the horizontal current shear is strong and radiation stress gradients, bottom stress, wind stress, horizontal mixing, and cross-shore advection contribute to alongshore momentum at different spatial locations across the near-shore region. Horizontal mixing during Hurricane Earl, estimated from rotational velocities, was particularly strong suggesting that intense eddies were generated by the high horizontal shear from opposing wind-driven and wave-driven currents. The results provide insight into the cross-shore distribution of the alongshore current and the connection between flows inside and outside the surf zone during major storms, indicating that the current shear and mixing at the interface between the surf zone and shallow inner shelf is strongly dependent on the distance from the storm center to the coast.
C1 [Mulligan, Ryan P.] Queens Univ, Dept Civil Engn, Kingston, ON K7L 3N6, Canada.
[Hanson, Jeffrey L.] US Army Corps Engn, Field Res Facil, Duck, NC USA.
[Hanson, Jeffrey L.] WaveForce Technol LLC, Kill Devil Hills, NC USA.
RP Mulligan, RP (reprint author), Queens Univ, Dept Civil Engn, Kingston, ON K7L 3N6, Canada.
EM mulligar@queensu.ca
FU Natural Science and Engineering Research Council of Canada (NSERC); U.S.
Army Corps of Engineers
FX This research was supported by a Natural Science and Engineering
Research Council of Canada (NSERC) Discovery Grant to the first author,
and funding for the instrumentation was provided by the U.S. Army Corps
of Engineers. The data used in this work are archived by the U.S. Army
Corps of Engineers at the Field Research Facility (FRF) in Duck, NC, and
can be accessed at http://www.frf.usace.army.mil/. We thank anonymous
reviewers for insightful comments on the original manuscript. Thanks to
Kent Hathaway and the FRF staff for maintaining the sensors, cables, and
data that provide a solid foundation for nearshore research.
NR 40
TC 0
Z9 0
U1 2
U2 2
PU AMER GEOPHYSICAL UNION
PI WASHINGTON
PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA
SN 2169-9275
EI 2169-9291
J9 J GEOPHYS RES-OCEANS
JI J. Geophys. Res.-Oceans
PD JUN
PY 2016
VL 121
IS 6
BP 4178
EP 4193
DI 10.1002/2016JC011706
PG 16
WC Oceanography
SC Oceanography
GA DW2JD
UT WOS:000383467800029
ER
PT J
AU Miller, AS
Durham, SW
Han, JJ
AF Miller, Alex S.
Durham, Susan W.
Han, Jasmine J.
TI Use of Intravenous Thrombolysis to Treat Postoperative Ischemic Stroke
After Gynecologic Surgery
SO JOURNAL OF GYNECOLOGIC SURGERY
LA English
DT Article
ID PERIOPERATIVE STROKE; INTRAARTERIAL THROMBOLYSIS; SAFETY
AB Background: Postoperative acute ischemic stroke may be associated with significant morbidity and mortality. Available treatment options have been limited because of concern about the risk for substantial postoperative bleeding. Data regarding the safety and use of intravenous (I.V.) thrombolysis in postoperative patients has been sparse. Case: A 62-year-old postmenopausal female had an acute ischemic stroke that occurred <1 hour after surgical excision of a vaginal mass. Administration of I.V. alteplase similar to 3.5 hours following the onset of this cerebrovascular accident resulted in complete resolution of symptoms. Bleeding from the surgical site was minimal. Results: To date, this patient has no permanent neurologic deficit secondary to her perioperative acute ischemic stroke. Conclusions: With close surveillance in carefully selected patients, I.V. thrombolysis may be a viable treatment option for acute ischemic stroke following low-risk gynecologic surgical procedures.
C1 [Miller, Alex S.; Durham, Susan W.; Han, Jasmine J.] Womack Army Med Ctr, Dept Obstet & Gynecol, Ft Bragg, NC USA.
RP Miller, AS (reprint author), 2817 Reilly Rd, Ft Bragg, NC 28310 USA.
EM alex.s.miller3.mil@mail.mil
NR 10
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1042-4067
EI 1557-7724
J9 J GYNECOL SURG
JI J. Gynecol. Surg.
PD JUN
PY 2016
VL 32
IS 3
BP 201
EP 203
DI 10.1089/gyn.2015.0128
PG 3
WC Obstetrics & Gynecology; Surgery
SC Obstetrics & Gynecology; Surgery
GA DU4FZ
UT WOS:000382169500012
ER
PT J
AU Wise, JE
AF Wise, Joseph E.
TI Survival of the Nicest: How Altruism Made Us Human and Why It Pays to
Get Along
SO PSYCHIATRY-INTERPERSONAL AND BIOLOGICAL PROCESSES
LA English
DT Book Review
C1 [Wise, Joseph E.] US Army, Med Corps, Ft Knox, KY USA.
[Wise, Joseph E.] Uniformed Serv Univ Hlth Sci, Walter Reed Natl Mil Med Ctr, Psychiat, Bethesda, MD USA.
RP Wise, JE (reprint author), Uniformed Serv Univ Hlth Sci, Walter Reed Natl Mil Med Ctr, Psychiat, Bethesda, MD USA.; Wise, JE (reprint author), Uniformed Serv Univ Hlth Sci, Walter Reed Natl Mil Med Ctr, 8901 Rockville Pike, Bethesda, MD 20889 USA.
EM joseph.e.wise.mil@mail.mil
NR 8
TC 0
Z9 0
U1 6
U2 6
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0033-2747
EI 1943-281X
J9 PSYCHIATRY
JI Psychiatry-Interpers. Biol. Process.
PD SUM
PY 2016
VL 79
IS 2
BP 170
EP 173
DI 10.1080/00332747.2016.1179506
PG 4
WC Psychiatry
SC Psychiatry
GA DT9UC
UT WOS:000381846800006
PM 27724832
ER
PT J
AU Boyer, NL
Forbes, DA
Chung, KK
AF Boyer, Nathan L.
Forbes, Damon A.
Chung, Kevin K.
TI Practical management of burns and inhalation injury
SO CURRENT PULMONOLOGY REPORTS
LA English
DT Article
DE Smoke inhalation injury; Bronchoscopy; Injury severity; Burns
ID RESTING ENERGY-EXPENDITURE; COMPUTED TOMOGRAPHIC SCANS;
SMOKE-INHALATION; RESUSCITATION; GUIDELINES; SEVERITY; CASUALTIES;
DIAGNOSIS; EFFICACY; SEPSIS
AB Burn injuries are often associated with profound physiologic derangements due to the nature of the underlying injuries and the overwhelming inflammatory response that ensues. In recent decades, a number of advancements have been made in the management of thermal burns. Inhalation injury frequently occurs in patients with thermal burns and can be a significant source of morbidity and mortality. Due to the intense inflammatory response that occurs after a burn injury, early aggressive volume resuscitation is necessary to minimize the risk of developing multiorgan dysfunction. Adequate sedation and analgesia, early enteral nutrition, physical rehabilitation, excision and grafting, and other supportive measures are also critically important to promoting healing and improving long-term outcomes. This review outlines a general approach to the management of patients with burn and inhalation injuries and highlights some of the recent advances in the care of these patients.
C1 [Boyer, Nathan L.; Forbes, Damon A.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA.
[Chung, Kevin K.] US Army, Inst Surg Res, 3698 Chambers Pass STE B, Ft Sam Houston, TX 78234 USA.
[Chung, Kevin K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Boyer, Nathan L.; Forbes, Damon A.] Brooke Army Med Ctr, Pulm & Crit Care Serv, Dept Med, Ft Sam Houston, TX 78234 USA.
RP Chung, KK (reprint author), US Army, Inst Surg Res, 3698 Chambers Pass STE B, Ft Sam Houston, TX 78234 USA.; Chung, KK (reprint author), Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
EM nathan.l.boyer.mil@mail.mil; damon.a.forbes.mil@mail.mil;
kevin.k.chung.mil@mail.mil
NR 36
TC 0
Z9 0
U1 2
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
EI 2199-2428
J9 CURR PULMONOL REP
JI Curr. Pulmonol. Rep.
PD JUN
PY 2016
VL 5
IS 2
BP 63
EP 69
DI 10.1007/s13665-016-0140-1
PG 7
WC Respiratory System
SC Respiratory System
GA DU9AG
UT WOS:000382508000001
ER
PT J
AU Bell, DG
McCann, ET
AF Bell, David G.
McCann, Edward T.
TI Transfusions in trauma
SO CURRENT PULMONOLOGY REPORTS
LA English
DT Article
DE Trauma; Transfusion; Resuscitation; Coagulopathy
ID BLOOD-CELL TRANSFUSIONS; ACTIVATED FACTOR-VII; HEMOSTATIC RESUSCITATION;
FLUID RESUSCITATION; HEMORRHAGIC-SHOCK; IMPROVED SURVIVAL;
CONTROLLED-TRIAL; TRANEXAMIC ACID; CLINICAL-TRIALS; DAMAGE CONTROL
AB Trauma associated with massive bleeding carries a high mortality even in the setting of early care in a trauma center. Such patients develop a significant coagulopathy soon after injury which contributes to these poor outcomes. Practices such as aggressive resuscitation with crystalloid fluids and red blood cell (RBC) transfusions appear to be associated with worse outcomes when compared to a practice of early blood product resuscitation with a ratio of plasma to platelets to RBCs approaching 1:1:1. Early therapy with tranexamic acid (TXA) appears beneficial as well, perhaps helping to prevent fibrinolysis. Viscoelastic testing offers advantages over conventional coagulation testing in the evaluation of further fibrinolysis and offers some guidance for additional targeted therapy. Many societies and organizations have released updated guidelines and recommendations that reflect these changes.
C1 [Bell, David G.; McCann, Edward T.] Brooke Army Med Ctr, Pulm Dis Serv, Dept Med, 3551 Roger Brooke Dr, San Antonio, TX 78234 USA.
RP Bell, DG (reprint author), Brooke Army Med Ctr, Pulm Dis Serv, Dept Med, 3551 Roger Brooke Dr, San Antonio, TX 78234 USA.
EM david.g.bell.mil@mail.mil; edward.t.mccann2.mil@mail.mil
NR 49
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
EI 2199-2428
J9 CURR PULMONOL REP
JI Curr. Pulmonol. Rep.
PD JUN
PY 2016
VL 5
IS 2
BP 94
EP 100
DI 10.1007/s13665-016-0141-0
PG 7
WC Respiratory System
SC Respiratory System
GA DU9AG
UT WOS:000382508000005
ER
PT J
AU Choi, Y
AF Choi, Yong
TI Comment on: Concomitant removal of gastric band and sleeve gastrectomy:
analysis of outcomes and complications from the ACS-NSQIP database
SO SURGERY FOR OBESITY AND RELATED DISEASES
LA English
DT Editorial Material
ID CONVERSION; SURGERY; BYPASS
C1 [Choi, Yong] Dwight D Eisenhower Army Med Ctr, Gen Surg Clin, Surg, Ft Gordon, GA 30905 USA.
RP Choi, Y (reprint author), Dwight D Eisenhower Army Med Ctr, Gen Surg Clin, Surg, Ft Gordon, GA 30905 USA.
NR 7
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1550-7289
EI 1878-7533
J9 SURG OBES RELAT DIS
JI Surg. Obes. Relat. Dis.
PD JUN
PY 2016
VL 12
IS 5
BP 989
EP 990
PG 2
WC Surgery
SC Surgery
GA DT9RM
UT WOS:000381840000009
PM 26975803
ER
PT J
AU Jain, A
Kuo, C
Jayakumar, P
Cameron, J
AF Jain, Abhinandan
Kuo, Calvin
Jayakumar, Paramsothy
Cameron, Jonathan
TI CONSTRAINT EMBEDDING FOR VEHICLE SUSPENSION DYNAMICS
SO ARCHIVE OF MECHANICAL ENGINEERING
LA English
DT Article
AB The goal of this research is to achieve close to real-time dynamics performance for allowing auto-pilot in-the-loop testing of unmanned ground vehicles (UGV) for urban as well as off-road scenarios. The overall vehicle dynamics performance is governed by the multibody dynamics model for the vehicle, the wheel/terrain interaction dynamics and the onboard control system. The topic of this paper is the development of computationally efficient and accurate dynamics model for ground vehicles with complex suspension dynamics. A challenge is that typical vehicle suspensions involve closed-chain loops which require expensive DAE integration techniques. In this paper, we illustrate the use the alternative constraint embedding technique to reduce the cost and improve the accuracy of the dynamics model for the vehicle.
C1 [Jain, Abhinandan; Cameron, Jonathan] CALTECH, Jet Prop Lab, 4800 Oak Grove Dr, Pasadena, CA 91016 USA.
[Kuo, Calvin] Stanford Univ, Dept Mech Engn, Palo Alto, CA 91016 USA.
[Jayakumar, Paramsothy] US Army TARDEC, 6501 E 11 Mile Rd, Warren, MI 48397 USA.
RP Jain, A (reprint author), CALTECH, Jet Prop Lab, 4800 Oak Grove Dr, Pasadena, CA 91016 USA.
EM jain@jpl.nasa.gov; calvink@stanford.edu;
paramsothy.jayakumar.civ@mail.mil; jmc@jpl.nasa.gov
NR 11
TC 0
Z9 0
U1 3
U2 3
PU DE GRUYTER OPEN LTD
PI WARSAW
PA BOGUMILA ZUGA 32A ST, 01-811 WARSAW, POLAND
SN 0004-0738
EI 2300-1895
J9 ARCH MECH ENG
JI Arch. Mech. Eng.
PD JUN
PY 2016
VL 63
IS 2
BP 193
EP 213
DI 10.1515/meceng-2016-0011
PG 21
WC Engineering, Mechanical
SC Engineering
GA DT7AC
UT WOS:000381635500002
ER
PT J
AU Park, J
Murphey, YL
Masrur, MA
AF Park, Jungme
Murphey, Yi Lu
Masrur, M. Abul
TI Intelligent Energy Management and Optimization in a Hybridized
All-Terrain Vehicle With Simple On-Off Control of the Internal
Combustion Engine
SO IEEE TRANSACTIONS ON VEHICULAR TECHNOLOGY
LA English
DT Article
DE Cognitive vehicle energy management; energy optimization; hybrid
electric vehicle (HEV); machine learning
ID ELECTRIC VEHICLES; POWER MANAGEMENT; STRATEGY; SYSTEM; TRUCK
AB This paper presents research in cognitive vehicle energy management for low-cost hybrid electric vehicle ( HEV) power systems for small vehicles, such as all-terrain vehicles ( ATVs). The power system consists of a small engine, a lead-acid battery, and an ultracapacitor. For simplicity of implementation and low hardware cost, engine control is restricted to two states, i. e., ON and OFF, and vehicle speed control is restricted to three discrete levels, namely, high, medium, and low. The authors developed advanced algorithms for modeling and optimizing vehicle energy flow, machine learning of optimal control settings generated by dynamic programmling on real-world drive cycles, and an intelligent energy controller designed for online energy control based on knowledge about the driving mission and knowledge obtained through machine learning. The intelligent vehicle energy controller cognitive intelligent power management ( CIPM) has been implemented and evaluated in a simulated vehicle model and in an ATV, i. e., Polaris Ranger EV, which was converted to an HEV. Experimental results show that the intelligent energy controller CIPM can lead to a significant improvement in fuel economy compared with the existing conventional vehicle controllers in an ATV.
C1 [Park, Jungme; Murphey, Yi Lu] Univ Michigan, Dept Elect & Comp Engn, Dearborn, MI 48128 USA.
[Masrur, M. Abul] US Army, RDECOM, TARDEC, Warren, MI 49307 USA.
RP Park, J (reprint author), Univ Michigan, Dept Elect & Comp Engn, Dearborn, MI 48128 USA.
EM jungmepark@gmail.com; yilu@umich.edu; m.a.masrur.civ@mail.mil
FU U.S. Army RDECOM-TARDEC
FX This work was supported in part by a research grant from the U.S. Army
RDECOM-TARDEC. The review of this paper was coordinated by Prof. M.
Benbouzid.
NR 27
TC 0
Z9 0
U1 8
U2 11
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0018-9545
EI 1939-9359
J9 IEEE T VEH TECHNOL
JI IEEE Trans. Veh. Technol.
PD JUN
PY 2016
VL 65
IS 6
BP 4584
EP 4596
DI 10.1109/TVT.2015.2466655
PG 13
WC Engineering, Electrical & Electronic; Telecommunications; Transportation
Science & Technology
SC Engineering; Telecommunications; Transportation
GA DR7GR
UT WOS:000380068500063
ER
PT J
AU Pasiakos, SM
Margolis, LM
Murphy, NE
McClung, HL
Martini, S
Gundersen, Y
Castellani, JW
Karl, JP
Teien, HK
Madslien, EH
Stenberg, PH
Young, AJ
Montain, SJ
McClung, JP
AF Pasiakos, Stefan M.
Margolis, Lee M.
Murphy, Nancy E.
McClung, Holy L.
Martini, Svein
Gundersen, Yngvar
Castellani, John W.
Karl, James P.
Teien, Hilde K.
Madslien, Elisabeth H.
Stenberg, Pal H.
Young, Andrew J.
Montain, Scott J.
McClung, James P.
TI Effects of exercise mode, energy, and macronutrient interventions on
inflammation during military training
SO PHYSIOLOGICAL REPORTS
LA English
DT Article
DE Endurance exercise; energy deficit; iron status; macronutrients
ID PLACEBO-CONTROLLED TRIAL; MUSCLE GLYCOGEN-CONTENT; IRON STATUS; FEMALE
SOLDIERS; HEPCIDIN LEVELS; PLASMA INTERLEUKIN-6; PHYSICAL PERFORMANCE;
CYTOKINE RESPONSES; SKELETAL-MUSCLE; SERUM HEPCIDIN
AB Load carriage (LC) exercise may exacerbate inflammation during training. Nutritional supplementation may mitigate this response by sparing endogenous carbohydrate stores, enhancing glycogen repletion, and attenuating negative energy balance. Two studies were conducted to assess inflammatory responses to acute LC and training, with or without nutritional supplementation. Study 1: 40 adults fed eucaloric diets performed 90-min of either LC (treadmill, mean +/- SD 24 +/- 3 kg LC) or cycle ergometry (CE) matched for intensity (2.2 +/- 0.1 VO2peak L min(-1)) during which combined 10 g protein/46 g carbohydrate (223 kcal) or non-nutritive (22 kcal) control drinks were consumed. Study 2: 73 Soldiers received either combat rations alone or supplemented with 1000 kcal day(-1) from 20 g protein-or 48 g carbohydrate-based bars during a 4-day, 51 km ski march (similar to 45 kg LC, energy expenditure 6155 +/- 515 kcal day(-1) and intake 2866 +/- 616 kcal day(-1)). IL-6, hepcidin, and ferritin were measured at baseline, 3-h post exercise (PE), 24-h PE, 48-h PE, and 72-h PE in study 1, and before (PRE) and after (POST) the 4-d ski march in study 2. Study 1: IL-6 was higher 3-h and 24-h post exercise (PE) for CE only (mode x time, P < 0.05), hepcidin increased 3-h PE and recovered by 48-h, and ferritin peaked 24-h and remained elevated 72-h PE (P < 0.05), regardless of mode and diet. Study 2: IL-6, hepcidin and ferritin were higher (P < 0.05) after training, regardless of group assignment. Energy expenditure (r = 0.40), intake (r = -0.26), and balance (r = -0.43) were associated (P < 0.05) with hepcidin after training. Inflammation after acute LC and CE was similar and not affected by supplemental nutrition during energy balance. The magnitude of hepcidin response was inversely related to energy balance suggesting that eating enough to balance energy expenditure might attenuate the inflammatory response to military training.
C1 [Pasiakos, Stefan M.; Margolis, Lee M.; Murphy, Nancy E.; McClung, Holy L.; Karl, James P.; Young, Andrew J.; Montain, Scott J.; McClung, James P.] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA USA.
[Martini, Svein; Gundersen, Yngvar; Teien, Hilde K.; Madslien, Elisabeth H.] Norwegian Def Res Estab, Kjeller, Norway.
[Castellani, John W.] US Army Res Inst Environm Med, Thermal Mt & Med Div, Natick, MA USA.
[Stenberg, Pal H.] Norwegian Navy, Gen Def Mat Catering & Combat Feeding Sect, Rodskiferveien, Norway.
RP Pasiakos, SM (reprint author), USARIEM, Mil Nutr Div, 15 Kansas St,Bldg 42, Natick, MA 01760 USA.
EM stefan.m.pasiakos.civ@mail.mil
RI Pasiakos, Stefan/E-6295-2014;
OI Pasiakos, Stefan/0000-0002-5378-5820; , Lee/0000-0002-0652-1304
NR 34
TC 1
Z9 1
U1 2
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2051-817X
J9 PHYSIOL REP
JI PHYSIOL. REP.
PD JUN
PY 2016
VL 4
IS 11
AR e12820
DI 10.14814/phy2.12820
PG 11
WC Physiology
SC Physiology
GA DS0AG
UT WOS:000380256900015
ER
PT J
AU Molle, A
Fabbri, F
Campi, D
Lamperti, A
Rotunno, E
Cinquanta, E
Lazzarini, L
Kaplan, D
Swaminathan, V
Bernasconi, M
Longo, M
Salviati, G
AF Molle, Alessandro
Fabbri, Filippo
Campi, Davide
Lamperti, Alessio
Rotunno, Enzo
Cinquanta, Eugenio
Lazzarini, Laura
Kaplan, Daniel
Swaminathan, Venkataraman
Bernasconi, Marco
Longo, Massimo
Salviati, Giancarlo
TI Evidence of Native Cs Impurities and Metal-Insulator Transition in MoS2
Natural Crystals
SO ADVANCED ELECTRONIC MATERIALS
LA English
DT Article
ID MOLYBDENUM-DISULFIDE; MONOLAYER MOS2; 2-DIMENSIONAL MATERIALS;
INTERCALATION COMPOUNDS; VALLEY POLARIZATION; ELECTRONICS; TRANSISTORS;
OPTOELECTRONICS; TRANSPORT; CONTACTS
AB In the realm of layered materials beyond graphene, MoS2 gains a primary role due to its semiconducting nature and n-type transport down to the 2D limit that makes it extremely appealing for electronic and optoelectronic applications. The intrinsic presence of defects causes MoS2 to undergo localization effects. In the present work, solid evidence of Cs impurities in bulky MoS2 crystals in a concentration well beyond the sensitivity threshold of independent compositional spectrometry probes is brought. Unlike conventional intercalation of alkali metals in MoS2, on the basis of the measured crystal structure and ab initio calculations, it is proposed that the incorporation of Cs is stabilized by complex where one Cs atom is associated with a double S vacancy therein resulting in an overall n-type doping of the MoS2. The field effect transistor based on this kind of Cs-doped MoS2 multilayer flakes exhibits a variable range hopping transport and a metal-insulator transition.
C1 [Molle, Alessandro; Lamperti, Alessio; Cinquanta, Eugenio; Longo, Massimo] CNR IMM, Lab MDM, Via C Olivetti 2, I-20864 Agrate Brianza, Italy.
[Fabbri, Filippo; Rotunno, Enzo; Lazzarini, Laura; Salviati, Giancarlo] IMEM CNR, Parco Area Sci 37a, I-43124 Parma, Italy.
[Campi, Davide; Bernasconi, Marco] Univ Milano Bicocca, Dipartimento Sci Mat, Via R Cozzi 55, I-20125 Milan, Italy.
[Kaplan, Daniel; Swaminathan, Venkataraman] US Army RDECOM ARDEC, Fuze Precis Armaments & Technol Directorate, Picatinny Arsenal, NJ 07806 USA.
RP Molle, A (reprint author), CNR IMM, Lab MDM, Via C Olivetti 2, I-20864 Agrate Brianza, Italy.; Salviati, G (reprint author), IMEM CNR, Parco Area Sci 37a, I-43124 Parma, Italy.; Bernasconi, M (reprint author), Univ Milano Bicocca, Dipartimento Sci Mat, Via R Cozzi 55, I-20125 Milan, Italy.
EM alessandro.molle@mdm.imm.cnr.it; marco.bernasconi@unimib.it;
giancarlo.salviati@cnr.it
RI lazzarini, laura/B-7009-2015; Longo, Massimo/G-8893-2013;
OI lazzarini, laura/0000-0001-5346-4026; Longo,
Massimo/0000-0002-6364-8184; Cinquanta, Eugenio
Luigi/0000-0002-4721-5215; Molle, Alessandro/0000-0002-3860-4120
FU U.S. Army [W911NF-14-1-0612]
FX The authors acknowledge D. Rotta for the fabrication of the
MoS2 devices. A.M., F.F, E.R., E.C., L.L., M.L., and G.S.
acknowledge funding from U.S. Army Award/Contract W911NF-14-1-0612.
NR 50
TC 1
Z9 1
U1 11
U2 17
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2199-160X
J9 ADV ELECTRON MATER
JI Adv. Electron. Mater.
PD JUN
PY 2016
VL 2
IS 6
AR 1600091
DI 10.1002/aelm.201600091
PG 9
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary;
Physics, Applied
SC Science & Technology - Other Topics; Materials Science; Physics
GA DR4ZI
UT WOS:000379912100013
ER
PT J
AU Cavender, AP
Ball, DB
AF Cavender, Anthony P.
Ball, Donald B.
TI Home Cures for Ailing Horses: A Case Study of Nineteenth-Century
Vernacular Veterinary Medicine in Tennessee
SO AGRICULTURAL HISTORY
LA English
DT Article
ID HISTORY
AB Vernacular human medicine, otherwise known as folk or popular medicine, has received considerable attention from scholars in the United States, but little research has been done on how lay people dealt with livestock ailments prior to the professionalization of veterinary medicine. Using Tennessee in the nineteenth century as a case study, this paper examines the corpus of popular knowledge on the identification and treatment of horse ailments available to lay people in printed sources, focusing primarily on newspapers and to a lesser extent on patent medicine brochures and horse care handbooks. Information on horse medicine found in the newspapers was often in the form of a letter to the editor or as an excerpt from another periodical. Collectively, newspapers served as a national clearing house for popular veterinary knowledge. An examination of the horse remedies reported in the newspapers and other printed materials shows a close correspondence between the materia medica and therapeutic modalities used for treating humans with those used for treating horses. The paper also considers folk remedies for horse ailments and folk healers known as "horse doctors," but the discussion is limited due to paucity of information available in the historical record.
C1 [Cavender, Anthony P.] East Tennessee State Univ, Anthropol, Johnson City, TN 37614 USA.
[Ball, Donald B.] US Army, Corps Engineers, Washington, DC 20310 USA.
RP Cavender, AP (reprint author), East Tennessee State Univ, Anthropol, Johnson City, TN 37614 USA.
NR 150
TC 0
Z9 0
U1 2
U2 2
PU AGRICULTURAL HISTORY SOCIETY
PI LITTLE ROCK
PA UALR, DEPT HISTORY, 2801 S UNIVERSITY AVE, LITTLE ROCK, AR 72324-1099
USA
SN 0002-1482
EI 1533-8290
J9 AGR HIST
JI Agric. Hist.
PD SUM
PY 2016
VL 90
IS 3
BP 311
EP 337
DI 10.3098/ah.2016.090.3.311
PG 27
WC Agriculture, Multidisciplinary; History; History & Philosophy Of Science
SC Agriculture; History; History & Philosophy of Science
GA DR4PP
UT WOS:000379885000002
ER
PT J
AU Roberts, D
Gebhardt, DL
Gaskill, SE
Roy, TC
Sharp, MA
AF Roberts, Delia
Gebhardt, Deborah L.
Gaskill, Steven E.
Roy, Tanja C.
Sharp, Marilyn A.
TI Current considerations related to physiological differences between the
sexes and physical employment standards
SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
LA English
DT Article; Proceedings Paper
CT 2nd International Conference on Physical Employment Standards (PES)
CY AUG 23-26, 2015
CL Canmore, CANADA
SP Univ Alberta, Fac Phys Educ & Recreat, Univ Alberta, Work Physiol Lab, Univ Alberta Conf Fund, Justice Inst British Columbia, No Alberta Inst Technol, Strathcona County Emergency Serv, UNIFOR, Appl Physiol, Nutr, & Metab, Canadian Sci Publisher, Univ, Occupat Testing Ctr, Canadian Soc Exercise Physiol, Edmonton Fire Rescue Serv, Edmonton Police Serv, Royal Canadian Mounted Police, K Div, Univ Alberta Int, Univ Alberta, Golden Bears Hockey, Univ Alberta, Golden Bears Volleyball, Univ Alberta, Pandas Hockey, Univ Alberta, Golden Bears Football, Univ Alberta, Canadian Athlet Coaching Ctr, Human Kinet Canada
DE physical employment standards; selection standards; sex differences;
job-task performance; work performance; occupational injury; physical
screening; physical selection
ID CORRECTIONAL OFFICER APPLICANTS; CRUCIATE LIGAMENT INJURY; ACUTE
MOUNTAIN-SICKNESS; FEMALE ARMY TRAINEES; RISK-FACTORS; UNITED-STATES; US
ARMY; FITNESS TEST; THERMOREGULATORY RESPONSES; MUSCULOSKELETAL INJURIES
AB The use of physical employment standards (PES) has helped ensure that workers have the physical attributes necessary to complete their jobs in a safe and efficient manner. However, PES used in the selection processes have not always reflected the critical physical requirements of the job tasks. Women generally have smaller anthropometric stature than men, less muscle mass, and therefore less strength, power, and endurance, particularly in the upper body. Nonetheless, these attributes in themselves are not valid grounds for exclusion from employment in physically demanding occupations. Selection standards based upon size or strength, irrespective of the job requirements, have resulted in the barring of capable women from physically demanding jobs, claims of gender bias, and costly litigations. To ensure all individuals are provided with equal access to employment, accurate characterization of the critical physical requirements of the job is paramount. This paper summarizes the existing research related to disparities between the sexes that contribute to sex differences in job performance in physically demanding occupations including physical and legal factors. Strategies for mitigating these differences in the setting of PES and the meeting of minimum employment standards are discussed. Where available, injury rates for women and men in physically demanding occupations are presented and the etiology considered. Finally, areas for further research are identified.
C1 [Roberts, Delia] Selkirk Coll, Sch Univ Arts & Sci, Amer Coll Sports Med FACSM, 2808 9th Ave, Castlegar, BC VIN 2Z1, Canada.
[Gebhardt, Deborah L.] Human Performance Syst Inc, 5000 Sunnyside Ave,Suite 203, Beltsville, MD 20705 USA.
[Gaskill, Steven E.] Univ Montana, Hlth & Human Performance Dept Exercise Sci, Missoula, MT 59812 USA.
[Roy, Tanja C.] US Army Publ Hlth Command, Epidemiol & Dis Surveillance, Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA.
[Sharp, Marilyn A.] US Army, Mil Performance Div, Environm Med Res Inst, 42 Gen Green Ave, Natick, MA 01760 USA.
RP Roberts, D (reprint author), Selkirk Coll, Sch Univ Arts & Sci, Amer Coll Sports Med FACSM, 2808 9th Ave, Castlegar, BC VIN 2Z1, Canada.
EM droberts@selkirk.ca
NR 99
TC 2
Z9 2
U1 4
U2 6
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 1715-5312
EI 1715-5320
J9 APPL PHYSIOL NUTR ME
JI Appl. Physiol. Nutr. Metab.
PD JUN
PY 2016
VL 41
IS 6
SU 2
BP S108
EP S120
DI 10.1139/apnm-2015-0540
PG 13
WC Nutrition & Dietetics; Physiology; Sport Sciences
SC Nutrition & Dietetics; Physiology; Sport Sciences
GA DQ8AE
UT WOS:000379430500007
PM 27277561
ER
PT J
AU Nguyen, LH
Tran, TD
AF Nguyen, Lam H.
Tran, Trac D.
TI Efficient and Robust RFI Extraction Via Sparse Recovery
SO IEEE JOURNAL OF SELECTED TOPICS IN APPLIED EARTH OBSERVATIONS AND REMOTE
SENSING
LA English
DT Article; Proceedings Paper
CT IEEE International Geoscience and Remote Sensing Symposium (IGARSS)
CY JUL 26-31, 2015
CL Milan, ITALY
SP IEEE
DE Compressed sensing (CS); interference; noise-source separation; radar;
radio-frequency interference (RFI); sparse recovery; sparsity; synthetic
aperture radar (SAR); ultra-wideband (UWB)
ID SYNTHETIC-APERTURE RADAR; WIDE-BAND RADAR; INTERFERENCE SUPPRESSION;
SIGNAL RECONSTRUCTION; MATCHING PURSUIT; SUBSPACE PURSUIT; SAR;
ALGORITHM; PROJECTIONS; SYSTEMS
AB This paper presents a simple adaptive framework for robust separation and extraction of multiple sources of radio-frequency interference (RFI) from raw ultra-wideband (UWB) radar signals in challenging bandwidth management environments. RFI sources pose critical challenges for UWB systems since 1) RFI often occupies a wide range of the radar's operating frequency spectrum; 2)RFI might have significant power; and 3) RFI signals are difficult to predict and model due to the nonstationary nature as well as the complexity of various communication devices. Our proposed framework involves an initial RFI estimation step that operates directly on already contaminated radar signals to identify RFI-dominant frequency sub-bands. This vital prior information is then taken into account to construct an adaptive RFI dictionary with various sinusoidal patterns covering the aforementioned RFI-contaminated frequency spectrum. Finally, we employ a sparsity-driven optimization strategy to separate and then extract RFI from the received radar signals. Our method can be implemented as a denoising preprocessing stage for raw radar signals prior to image formation and other follow-up tasks such as target detection and classification. Recovery results from extensive simulated data sets as well as real-world signals collected by the U.S. Army Research Laboratory (ARL) UWB synthetic aperture radar (SAR) systems illustrate the robustness and effectiveness of our proposed framework.
C1 [Nguyen, Lam H.] US Army Res Lab, RF Signal Proc & Modeling Branch, Adelphi, MD 20783 USA.
[Tran, Trac D.] Johns Hopkins Univ, Dept Elect & Comp Engn, Baltimore, MD 21218 USA.
RP Nguyen, LH (reprint author), US Army Res Lab, RF Signal Proc & Modeling Branch, Adelphi, MD 20783 USA.
EM lam.h.nguyen2.civ@mail.mil; trac@jhu.edu
NR 54
TC 0
Z9 0
U1 6
U2 6
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1939-1404
EI 2151-1535
J9 IEEE J-STARS
JI IEEE J. Sel. Top. Appl. Earth Observ. Remote Sens.
PD JUN
PY 2016
VL 9
IS 6
SI SI
BP 2104
EP 2117
DI 10.1109/JSTARS.2016.2528884
PG 14
WC Engineering, Electrical & Electronic; Geography, Physical; Remote
Sensing; Imaging Science & Photographic Technology
SC Engineering; Physical Geography; Remote Sensing; Imaging Science &
Photographic Technology
GA DR5HW
UT WOS:000379935100002
ER
PT J
AU Gurram, P
Kwon, H
Davidson, C
AF Gurram, Prudhvi
Kwon, Heesung
Davidson, Charles
TI Coalition Game Theory-Based Feature Subspace Selection for Hyperspectral
Classification
SO IEEE JOURNAL OF SELECTED TOPICS IN APPLIED EARTH OBSERVATIONS AND REMOTE
SENSING
LA English
DT Article; Proceedings Paper
CT IEEE International Geoscience and Remote Sensing Symposium (IGARSS)
CY JUL 26-31, 2015
CL Milan, ITALY
SP IEEE
DE Coalition game theory (CGT); feature selection; hyperspectral
classification; Shapely value (SV); sparse kernel learning
AB In this paper, an algorithm to randomly select feature subspaces for hyperspectral image classification using the principle of coalition game theory (CGT) is presented. The feature selection algorithms associated with nonlinear kernel-based support vector machines (SVM) are either NP-hard or greedy and hence, not very optimal. To deal with this problem, a metric based on the principles of CGT called Shapely value (SV) and a sampling approximation is used to determine the contributions of individual features toward the classification task. Feature subsets are randomly drawn from a probability distribution function (pdf) generated using normalized SVs of the individual features. These feature subsets are then used to build kernels corresponding to individual weak classifiers in the sparse kernel-based ensemble learning (SKEL) framework. By weighting the kernels optimally and sparsely, a small number of useful subsets of features are selected which improve the generalization performance of the ensemble classifier. The algorithm is applied on real hyperspectral datasets, and the results are presented in the paper.
C1 [Gurram, Prudhvi; Kwon, Heesung] US Army Res Lab, Adelphi, MD 20783 USA.
[Davidson, Charles] Sci & Technology Corp, Edgewood, MD 21040 USA.
RP Gurram, P (reprint author), US Army Res Lab, Adelphi, MD 20783 USA.
EM pkgurram@ieee.org; heesung.kwon.civ@mail.mil;
charles.e.davidson40.ctr@mail.mil
NR 19
TC 0
Z9 0
U1 6
U2 6
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1939-1404
EI 2151-1535
J9 IEEE J-STARS
JI IEEE J. Sel. Top. Appl. Earth Observ. Remote Sens.
PD JUN
PY 2016
VL 9
IS 6
SI SI
BP 2354
EP 2364
DI 10.1109/JSTARS.2016.2531984
PG 11
WC Engineering, Electrical & Electronic; Geography, Physical; Remote
Sensing; Imaging Science & Photographic Technology
SC Engineering; Physical Geography; Remote Sensing; Imaging Science &
Photographic Technology
GA DR5HW
UT WOS:000379935100022
ER
PT J
AU Sahane, D
Santare, MH
Powers, BM
Gazonas, GA
AF Sahane, Dattatraya
Santare, Michael H.
Powers, Brian M.
Gazonas, George A.
TI Computational simulations of wave propagation in microcrack-damaged
media under prestress
SO INTERNATIONAL JOURNAL OF FRACTURE
LA English
DT Article
DE Micro cracks; Damage; Waves; Numerical simulation; Prestress
ID ANISOTROPIC EFFECTIVE MODULI; BALLISTIC PERFORMANCE; CERAMIC TARGETS;
IMPACT; TILES; MODEL
AB Direct computational simulations of unidirectional wave propagation through uniaxially prestressed, microcrack-damaged media are conducted to study the interaction between the prestress and stress wave parameters. Tensile and compressive waves, tensile and compressive prestresses and various orientational distributions of microcrack damage are analyzed. The relationships among the input wave amplitude, wavelength and prestress magnitude and the output wave speed and wave attenuation are studied. The results show that wave speed and attenuation depend on the prestress and the wavelength in a complex way. In the cases of compressive waves traveling through tensile prestress and tensile waves passing through compressive prestress, the wave response depends on the ratio of the amplitude of the applied stress pulse to the magnitude of the prestress (defined as R). Specifically, the simulations show that the compressive wave speed through tensile prestressed media increases gradually with an increase in R, while the tensile wave speed in media under compressive prestress, decreases with increase in R, but the change is abrupt at a particular R value. In the cases of sufficiently small R, the wave speeds match the results of Su et al. (Eng Fract Mech 74: 1436-1455, 2007) where the cracks are always open or always closed. However, above a certain wavelength (a cut-off wavelength), the wave speed is no longer a function of wavelength and, furthermore, this cut-off wavelength varies with R.
C1 [Sahane, Dattatraya; Santare, Michael H.] Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA.
[Sahane, Dattatraya; Santare, Michael H.] Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA.
[Powers, Brian M.; Gazonas, George A.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen, MD 21005 USA.
RP Santare, MH (reprint author), Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA.; Santare, MH (reprint author), Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA.
EM santare@udel.edu
FU United States Army Research Laboratory through the Composite Materials
Technology; Center for Composite Materials at the University of Delaware
FX This research was supported by the United States Army Research
Laboratory through the Composite Materials Technology cooperative in
agreement with the Center for Composite Materials at the University of
Delaware.
NR 25
TC 0
Z9 0
U1 2
U2 2
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0376-9429
EI 1573-2673
J9 INT J FRACTURE
JI Int. J. Fract.
PD JUN
PY 2016
VL 199
IS 2
BP 185
EP 198
DI 10.1007/s10704-016-0103-0
PG 14
WC Materials Science, Multidisciplinary; Mechanics
SC Materials Science; Mechanics
GA DR6HF
UT WOS:000380002300004
ER
PT J
AU Skimmyhorn, WL
AF Skimmyhorn, William L.
TI Comparing Military and Civilian Household Finances: Descriptive Evidence
from Recent Surveys
SO JOURNAL OF CONSUMER AFFAIRS
LA English
DT Article
ID EDUCATION; LITERACY
AB Despite significant media and policy attention to the financial conditions of military and civilian households in American over the past few years, little is known about their relative standing and decision making. Using data from large national surveys, this analysis provides descriptive evidence on key differences for comparable young, low-moderate income and education military and civilian respondents. I find that military members have more types of savings accounts, more problematic credit card behaviors, and equivalent use of alternative financial services. I briefly discuss directions for future research and some policy implications.
C1 [Skimmyhorn, William L.] US Mil Acad, Dept Social Sci, Off Econ & Manpower Anal, West Point, NY 10996 USA.
RP Skimmyhorn, WL (reprint author), US Mil Acad, Dept Social Sci, Off Econ & Manpower Anal, West Point, NY 10996 USA.
EM william.skimmyhorn@usma.edu
FU FINRA Investor Education Foundation
FX This paper was prepared with financial support from the FINRA Investor
Education Foundation. The opinions provided herein are those of the
author and do not necessarily reflect the views of the Financial
Industry Regulatory Authority, the FINRA Investor Education Foundation,
the U.S. Military Academy, the Department of the Army, or the Department
of Defense.
NR 15
TC 0
Z9 0
U1 2
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-0078
EI 1745-6606
J9 J CONSUM AFF
JI J. Consum. Aff.
PD SUM
PY 2016
VL 50
IS 2
BP 471
EP 483
DI 10.1111/joca.12109
PG 13
WC Business; Economics
SC Business & Economics
GA DR7AV
UT WOS:000380053300009
ER
PT J
AU Acon-Chen, C
Koenig, JA
Smith, GR
Truitt, AR
Thomas, TP
Shih, TM
AF Acon-Chen, Cindy
Koenig, Jeffrey A.
Smith, Garrett R.
Truitt, Amber R.
Thomas, Thaddeus P.
Shih, Tsung-Ming
TI Evaluation of acetylcholine, seizure activity and neuropathology
following high-dose nerve agent exposure and delayed neuroprotective
treatment drugs in freely moving rats
SO TOXICOLOGY MECHANISMS AND METHODS
LA English
DT Article
DE Acetylcholine; adenosine receptor agonist; anticholinergics;
anticonvulsant; benzodiazepines; glutamate receptor antagonist;
microdialysis; midazolam; N6-Cyclopentyladenosine; nerve agent;
neuropathology; neuroprotectant; neurosteroids; scopolamine; soman
ID SOMAN-INDUCED SEIZURES; EXTRACELLULAR STRIATAL ACETYLCHOLINE; KAINATE
RECEPTOR ANTAGONIST; GUINEA-PIGS; ADENOSINE RECEPTORS; STATUS
EPILEPTICUS; GABA(A) RECEPTORS; IN-VIVO; ANTICONVULSANT TREATMENT;
BENZODIAZEPINE-RECEPTOR
AB Organophosphorus nerve agents such as soman (GD) inhibit acetylcholinesterase, producing an excess of acetylcholine (ACh), which results in respiratory distress, convulsions and status epilepticus that leads to neuropathology. Several drugs (topiramate, clobazam, pregnanolone, allopregnanolone, UBP 302, cyclopentyladenosine [CPA], ketamine, midazolam and scopolamine) have been identified as potential neuroprotectants that may terminate seizures and reduce brain damage. To systematically evaluate their efficacy, this study employed in vivo striatal microdialysis and liquid chromatography to respectively collect and analyze extracellular ACh in freely moving rats treated with these drugs 20min after seizure onset induced by a high dose of GD. Along with microdialysis, EEG activity was recorded and neuropathology assessed at 24h. GD induced a marked increase of ACh, which peaked at 30min post-exposure to 800% of control levels and then steadily decreased toward baseline levels. Approximately 40min after treatment, only midazolam (10mg/kg) and CPA (60mg/kg) caused a significant reduction of ACh levels, with CPA reducing ACh levels more rapidly than midazolam. Both drugs facilitated a return to baseline levels at least 55min after treatment. At 24h, only animals treated with CPA (67%), midazolam (18%) and scopolamine (27%) exhibited seizure termination. While all treatments except for topiramate reduced neuropathology, CPA, midazolam and scopolamine showed the greatest reduction in pathology. Our results suggest that delayed treatment with CPA, midazolam, or scopolamine is effective at reducing GD-induced seizure activity and neuropathology, with CPA and midazolam capable of facilitating a reduction in GD-induced ACh elevation.
C1 [Acon-Chen, Cindy; Koenig, Jeffrey A.; Smith, Garrett R.; Truitt, Amber R.; Thomas, Thaddeus P.; Shih, Tsung-Ming] US Army Med Res Inst Chem Def, Pharmacol Branch, Div Res, Aberdeen Proving Ground, MD 21010 USA.
RP Shih, TM (reprint author), US Army Med Res Inst Chem Def, 2900 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA.
EM tsungming.a.shih.civ@mail.mil
FU NIH/NIAID (IAA) [AOD14018-001-00000]; USAMRICD [A120-B.P2014-02]; U.S.
Department of Energy
FX This research was supported by an Interagency Agreement (IAA) between
NIH/NIAID (IAA #AOD14018-001-00000) and the USAMRICD (#A120-B.P2014-02)
for Chemicals Affecting the Nervous System -
Anticonvulsants/Neuroprotectants. This research was supported in part by
an appointment (Cindy Acon-Chen, Jeffrey A. Koenig, Garrett R. Smith,
and Amber R. Truitt) to the Postgraduate Research Participation Program
at the U.S. Army Medical Research Institute of Chemical Defense
administered by the Oak Ridge Institute for Science and Education
through an interagency agreement between the U.S. Department of Energy
and USAMRMC.
NR 75
TC 0
Z9 0
U1 2
U2 4
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1537-6516
EI 1537-6524
J9 TOXICOL MECH METHOD
JI Toxicol. Mech. Methods
PD JUN
PY 2016
VL 26
IS 5
BP 378
EP 388
DI 10.1080/15376516.2016.1197992
PG 11
WC Toxicology
SC Toxicology
GA DR7AT
UT WOS:000380053100010
PM 27329284
ER
PT J
AU Dougherty, CM
Xue, L
Pulskamp, J
Bedair, S
Polcawich, R
Morgan, B
Bashirullah, R
AF Dougherty, Christopher M.
Xue, Lin
Pulskamp, Jeffrey
Bedair, Sarah
Polcawich, Ronald
Morgan, Brian
Bashirullah, Rizwan
TI A 10 V Fully-Integrated Switched-Mode Step-up Piezo Drive Stage in 0.13
mu m CMOS Using Nested-Bootstrapped Switch Cells
SO IEEE JOURNAL OF SOLID-STATE CIRCUITS
LA English
DT Article
DE Arbitrary waveforms; bidirectional; boot-strapped switch; charge-pump;
dc-dc conversion; driver; fully integrated; piezo; switched-capacitor;
voltage-compliant
ID CONVERTER
AB A completely integrated 3.3 V to 10 Vpk-pk bidirectional switched-capacitor ladder converter is presented for driving the piezo actuators of a 2 mm wing micro-robotic flying insect. The 0.1-10 MHz converter, fabricated in 1.2 V/3.3 V triple-well 0.13 mu m CMOS, operates as a switched-mode amplifier with 0-3.3 V waveforms at the input and a constant 3x step-up while exhibiting symmetric drive strength for positive and negative load currents. A feedforward switching scheme that effectively bootstraps gate-drive signals for the power switches of the ladder converter has been implemented to enable output waveforms above both the supply and device voltage rating, between 0 V and similar to 10 V. Non-overlapping clock signals float with the dc-500 Hz arbitrary input waveform, or a 2x scaled replica, while keeping all transistors within safe operating conditions. A voltage compliant sub-circuit, the Nested-Bootstrapped Switch (NBS) cell, is introduced as a building block for the creation of the gate-drive signals. On-chip MIM capacitors and 3.3 V I/O MOS switches for the ladder converter were sized based on a charge-multiplier representation of the converter and the output impedance concept. Experiments show actuation of a 2 mm wing prototype, an effective 5 nF peak load, and efficiency of 77% at 800 mu W and 80% at 32 mu W.
C1 [Dougherty, Christopher M.] Texas Instruments Inc, D-85356 Freising Weihenstephan, Germany.
[Dougherty, Christopher M.; Xue, Lin; Bashirullah, Rizwan] Univ Florida, Dept Elect & Comp Engn, Gainesville, FL 32611 USA.
[Xue, Lin] Qualcomm Technol Inc, San Diego, CA 92121 USA.
[Pulskamp, Jeffrey; Bedair, Sarah; Polcawich, Ronald; Morgan, Brian] US Army Res Lab, Adelphi, MD 20783 USA.
RP Dougherty, CM (reprint author), Texas Instruments Inc, D-85356 Freising Weihenstephan, Germany.
EM chrisdoc@ufl.edu
FU U.S. Army Research Laboratory [W911NF-08-2-0035]
FX This work was supported by the U.S. Army Research Laboratory under
Agreement W911NF-08-2-0035.
NR 20
TC 0
Z9 0
U1 4
U2 4
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0018-9200
EI 1558-173X
J9 IEEE J SOLID-ST CIRC
JI IEEE J. Solid-State Circuit
PD JUN
PY 2016
VL 51
IS 6
BP 1475
EP 1486
DI 10.1109/JSSC.2016.2551221
PG 12
WC Engineering, Electrical & Electronic
SC Engineering
GA DR2QD
UT WOS:000379748100012
ER
PT J
AU Perliger, A
Koehler-Derrick, G
Pedahzur, A
AF Perliger, Arie
Koehler-Derrick, Gabriel
Pedahzur, Ami
TI The Gap Between Participation and Violence: Why We Need to Disaggregate
Terrorist 'Profiles'
SO INTERNATIONAL STUDIES QUARTERLY
LA English
DT Article
ID POLITICAL VIOLENCE; SUICIDE TERRORISM; NETWORK ANALYSIS; RECRUITMENT;
POVERTY; RADICALIZATION; EXPLORATION; CENTRALITY; EDUCATION; MEMBERS
AB For decades, practitioners and academics sought to identify a common terrorist "profile." However, the consensus in both the policy realm and academia suggests that, so far, these efforts produced only modest insights. This research note identifies and addresses a major impediment to previous studies of terrorist profiles: conceptualization. We argue that ambiguities in the definition of the term terrorist lead to an inconsistent and aggregated operationalization in the existing literature. Previous studies attempt to identify the factors correlated with a willingness to commit violence rather than the factors that correlate with the willingness to join an organization that commits violence. We test our claim by disaggregating the roles and responsibilities of members of various Islamist terrorist networks. We provide initial evidence that disaggregation presents a promising first step toward identifying specific profiles for different types of terrorists.
C1 [Perliger, Arie] US Mil Acad, Combating Terrorism Ctr, Terrorism Studies, West Point, NY 10996 USA.
[Perliger, Arie] US Mil Acad, Dept Social Sci, West Point, NY 10996 USA.
[Koehler-Derrick, Gabriel] Harvard Univ, Dept Govt, Cambridge, MA 02138 USA.
[Pedahzur, Ami] Univ Texas Austin, Govt, Austin, TX 78712 USA.
[Pedahzur, Ami] Univ Texas Austin, Israel & Diaspora Studies, Austin, TX 78712 USA.
RP Perliger, A (reprint author), US Mil Acad, Combating Terrorism Ctr, Terrorism Studies, West Point, NY 10996 USA.; Perliger, A (reprint author), US Mil Acad, Dept Social Sci, West Point, NY 10996 USA.
EM aperliger@gmail.com
NR 80
TC 1
Z9 1
U1 14
U2 16
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0020-8833
EI 1468-2478
J9 INT STUD QUART
JI Int. Stud. Q.
PD JUN
PY 2016
VL 60
IS 2
BP 220
EP 229
DI 10.1093/isq/sqv010
PG 10
WC International Relations; Political Science
SC International Relations; Government & Law
GA DR2UE
UT WOS:000379758600003
ER
PT J
AU Le Gonidec, E
Maquart, M
Duron, S
Savini, H
Cazajous, G
Vidal, PO
Chenilleau, MC
Roseau, JB
Benois, A
Dehan, C
Kugelman, J
Leparc-Goffart, I
Vedy, S
AF Le Gonidec, Erwan
Maquart, Marianne
Duron, Sandrine
Savini, Helene
Cazajous, Geraldine
Vidal, Pierre-Olivier
Chenilleau, Marie-Caroline
Roseau, Jean-Baptiste
Benois, Alain
Dehan, Celine
Kugelman, Jeffrey
Leparc-Goffart, Isabelle
Vedy, Serge
TI Clinical Survey of Dengue Virus Circulation in the Republic of Djibouti
between 2011 and 2014 Identifies Serotype 3 Epidemic and Recommends
Clinical Diagnosis Guidelines for Resource Limited Settings
SO PLOS NEGLECTED TROPICAL DISEASES
LA English
DT Article
ID SURVEILLANCE; INFECTION; AFRICA
AB Dengue virus is endemic globally, throughout tropical and sub-tropical regions. While the number of epidemics due to the four DENV serotypes is pronounced in East Africa, the total number of cases reported in Africa (16 million infections) remained at low levels compared to Asia (70 million infections). The French Armed forces Health Service provides epidemiological surveillance support in the Republic of Djibouti through the Bouffard Military hospital. Between 2011 and 2014, clinical and biological data of suspected dengue syndromes were collected at the Bouffard Military hospital and analyzed to improve Dengue clinical diagnosis and evaluate its circulation in East Africa. Examining samples from patients that presented one or more Dengue-like symptoms the study evidenced 128 Dengue cases among 354 suspected cases (36.2% of the non-malarial Dengue-like syndromes). It also demonstrated the circulation of serotypes 1 and 2 and reports the first epidemic of serotype 3 infections in Djibouti which was found in all of the hospitalized patients in this study. Based on these results we have determined that screening for Malaria and the presence of the arthralgia, gastro-intestinal symptoms and lymphopenia <1,000cell/mm(3) allows for negative predictive value and specificity of diagnosis in isolated areas superior to 80% up to day 6. This study also provides evidence for an epidemic of Dengue virus serotype 3 previously not detected in Djibouti.
C1 [Le Gonidec, Erwan; Vidal, Pierre-Olivier] Bouffard Mil Hosp, Emergency Dept, Djibouti, Djibouti.
[Maquart, Marianne; Kugelman, Jeffrey; Leparc-Goffart, Isabelle] Armed Forces Biomed Res Inst, French Natl Reference Ctr Arbovirus, Marseille, France.
[Duron, Sandrine] GSBdD Marseille Aubagne, French Armed Forces Ctr Epidemiol & Publ Hlth CES, Marseille, France.
[Savini, Helene] Laveran Mil Teaching Hosp, Dept Infect & Trop Dis, Marseille, France.
[Cazajous, Geraldine; Chenilleau, Marie-Caroline; Roseau, Jean-Baptiste] Bouffard Mil Hosp, Dept Med, Djibouti, Djibouti.
[Benois, Alain] Bouffard Mil Hosp, Dept Anesthesiol & Intens Care, Djibouti, Djibouti.
[Dehan, Celine; Vedy, Serge] Bouffard Mil Hosp, Dept Biol, Djibouti, Djibouti.
[Kugelman, Jeffrey] US Army Med Res & Mat Command, Ft Detrick, MD USA.
RP Maquart, M (reprint author), Armed Forces Biomed Res Inst, French Natl Reference Ctr Arbovirus, Marseille, France.
EM mmaquart.irba@gmail.com
NR 27
TC 0
Z9 0
U1 3
U2 4
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1935-2735
J9 PLOS NEGLECT TROP D
JI Plos Neglect. Trop. Dis.
PD JUN
PY 2016
VL 10
IS 6
AR e0004755
DI 10.1371/journal.pntd.0004755
PG 10
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA DQ6WL
UT WOS:000379346200023
PM 27322644
ER
PT J
AU McNesby, KL
Homan, BE
Benjamin, RA
Boyle, VM
Densmore, JM
Biss, MM
AF McNesby, Kevin L.
Homan, Barrie E.
Benjamin, Richard A.
Boyle, Vincent M.
Densmore, John M.
Biss, Matthew M.
TI Invited Article: Quantitative imaging of explosions with high-speed
cameras
SO REVIEW OF SCIENTIFIC INSTRUMENTS
LA English
DT Article
ID PYROMETRY; TEMPERATURE; COMBUSTION; PRESSURE; FLAMES; SOOT; AIR;
DIAGNOSTICS; FIREBALLS; EMISSION
AB The techniques presented in this paper allow for mapping of temperature, pressure, chemical species, and energy deposition during and following detonations of explosives, using high speed cameras as the main diagnostic tool. This work provides measurement in the explosive near to far-field (0-500 charge diameters) of surface temperatures, peak air-shock pressures, some chemical species signatures, shock energy deposition, and air shock formation.
C1 [McNesby, Kevin L.; Homan, Barrie E.; Benjamin, Richard A.] Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Boyle, Vincent M.] TKC Global, Aberdeen Proving Ground, MD 21005 USA.
[Densmore, John M.] Lawrence Livermore Natl Lab, Livermore, CA 94550 USA.
[Biss, Matthew M.] Los Alamos Natl Lab, Los Alamos, NM 87545 USA.
RP McNesby, KL (reprint author), Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
NR 79
TC 1
Z9 1
U1 6
U2 11
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0034-6748
EI 1089-7623
J9 REV SCI INSTRUM
JI Rev. Sci. Instrum.
PD JUN
PY 2016
VL 87
IS 5
AR 051301
DI 10.1063/1.4949520
PG 14
WC Instruments & Instrumentation; Physics, Applied
SC Instruments & Instrumentation; Physics
GA DQ4QE
UT WOS:000379187600001
PM 27250366
ER
PT J
AU Keller, CB
Rafuse, ES
AF Keller, Christian B.
Rafuse, Ethan S.
TI The Civil War Battlefield Staff Ride in the Twenty-first Century
SO CIVIL WAR HISTORY
LA English
DT Article
C1 [Keller, Christian B.] US Army, War Coll, Dept Natl Secur & Strategy, Hist, Carlisle, PA 17013 USA.
[Rafuse, Ethan S.] US Army, Command & Gen Staff Coll, Hist, Ft Leavenworth, KS USA.
RP Keller, CB (reprint author), US Army, War Coll, Dept Natl Secur & Strategy, Hist, Carlisle, PA 17013 USA.
NR 37
TC 0
Z9 0
U1 0
U2 0
PU KENT STATE UNIV PRESS
PI KENT
PA C/O JOURNALS DEPT, KENT, OH 44242 USA
SN 0009-8078
EI 1533-6271
J9 CIVIL WAR HIST
JI Civil War Hist.
PD JUN
PY 2016
VL 62
IS 2
BP 201
EP 213
PG 13
WC History
SC History
GA DQ1SI
UT WOS:000378980300006
ER
PT J
AU Ananworanich, J
Abrams, EJ
AF Ananworanich, Jintanat
Abrams, Elaine J.
TI Time to prioritise the UNAIDS 90-90-90 targets for infants
SO LANCET HIV
LA English
DT Editorial Material
ID CHILD HIV TRANSMISSION; ANTIRETROVIRAL THERAPY; INFECTED INFANTS;
DIAGNOSIS; MORTALITY; ELIMINATION; CHALLENGES
C1 [Ananworanich, Jintanat] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA.
[Ananworanich, Jintanat] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD 20817 USA.
[Abrams, Elaine J.] Columbia Univ, Int Ctr AIDS Care & Treatment Programs, Mailman Sch Publ Hlth, New York, NY USA.
[Abrams, Elaine J.] Columbia Univ, Coll Phys & Surg, New York, NY USA.
RP Ananworanich, J (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA.; Ananworanich, J (reprint author), Henry M Jackson Fdn Adv Mil Med, Bethesda, MD 20817 USA.
EM jananworanich@hivresearch.org
NR 13
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U1 0
U2 0
PU ELSEVIER INC
PI SAN DIEGO
PA 525 B STREET, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 2352-3018
J9 LANCET HIV
JI Lancet HIV
PD JUN
PY 2016
VL 3
IS 6
BP E241
EP E243
DI 10.1016/S2352-3018(16)30013-3
PG 4
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA DQ1GS
UT WOS:000378950100003
PM 27240784
ER
PT J
AU Snyder, BA
Munter, AD
Houston, MN
Hoch, JM
Hoch, MC
AF Snyder, Brice A.
Munter, Alexander D.
Houston, Megan N.
Hoch, Johanna M.
Hoch, Matthew C.
TI INTERRATER AND INTRARATER RELIABILITY OF THE SEMMES-WEINSTEIN
MONOFILAMENT 4-2-1 STEPPING ALGORITHM
SO MUSCLE & NERVE
LA English
DT Article
DE feet; light touch; Semmes Weinstein monofilament; sensation;
somatosensory
ID CHRONIC ANKLE INSTABILITY; SENSATION TESTS; INJURIES; INDIVIDUALS;
SENSITIVITY; SPORTS; OSTEOARTHRITIS; EPIDEMIOLOGY; SENSIBILITY;
THRESHOLD
AB Introduction: Semmes-Weinstein Monofilaments (SWM) are used to examine light touch sensation of the skin. Reliability of the 4-2-1 stepping algorithm approach for determining light touch detection thresholds has not been examined. The purpose of this study was to determine the interrater and intrarater reliability of the SWM 4-2-1 stepping algorithm on the plantar surface of the foot. Methods: Four raters with varying levels of SWM assessment experience tested light touch sensation over the plantar aspect of the first metatarsal head in 14 healthy adults. During the initial session, all raters performed the 4-2-1 stepping algorithm technique on each subject to determine interrater reliability. One week later, subjects were reassessed by 2 raters to determine intrarater reliability. Results: Interrater reliability ranged from moderate-to-good (ICC2,1 = 0.62-0.92). Intrarater reliability also ranged from moderate-to-good (ICC2,1 = 0.61-0.85). Conclusions The 4-2-1 stepping algorithm demonstrated acceptable interrater and intrarater reliability when measured in healthy adults.
C1 [Snyder, Brice A.; Munter, Alexander D.; Hoch, Johanna M.; Hoch, Matthew C.] Old Dominion Univ, Sch Phys Therapy & Athlet Training, Norfolk, VA 23529 USA.
[Houston, Megan N.] Keller Army Community Hosp, West Point, NY USA.
RP Hoch, MC (reprint author), Old Dominion Univ, Sch Phys Therapy & Athlet Training, Norfolk, VA 23529 USA.
EM mhoch@odu.edu
NR 33
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Z9 4
U1 1
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0148-639X
EI 1097-4598
J9 MUSCLE NERVE
JI Muscle Nerve
PD JUN
PY 2016
VL 53
IS 6
BP 918
EP 924
DI 10.1002/mus.24944
PG 7
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA DQ2HK
UT WOS:000379023200014
PM 26474392
ER
PT J
AU Just, MG
Hohmann, MG
Hoffmann, WA
AF Just, Michael G.
Hohmann, Matthew G.
Hoffmann, William A.
TI Where fire stops: vegetation structure and microclimate influence fire
spread along an ecotonal gradient
SO PLANT ECOLOGY
LA English
DT Article
DE Feedback; Fire ecology; Longleaf pine; Savanna; Streamhead pocosin;
Wetland
ID LONGLEAF PINE ECOSYSTEM; SAVANNA-FOREST TRANSITION; ECOLOGICAL
THRESHOLDS; POSITIVE FEEDBACKS; MODELS; RISK; FUEL; RESTORATION;
TEMPERATURE; CONVERSION
AB Positive feedbacks influenced by direct and indirect interactions between fire, vegetation, and microclimate can allow pyrophilic and pyrophobic ecosystems to co-occur in the same landscape, resulting in the juxtaposition of flammable and non-flammable vegetation. To quantify the drivers of these feedbacks, we combined measurements of vegetation, fuels, and microclimate with observations of fire spread along ecotonal gradients. We established 113 permanent transects (consisting of 532 plots), each traversing an ecotone between savanna and wetland in the Sandhills of North Carolina, USA. In each plot, we recorded cover of ten plant functional types. We collected surface fuels at a subset of our transects. We continuously monitored microclimate (nine meteorological variables) across 21 representative ecotones. Following prescribed fire, we measured fire spread along each transect. Vegetation structure and microclimate significantly predicted fire spread along the savanna-wetland ecotone. Fire spread was most influenced by vegetation structure, specifically C-4 grass cover, which accounted for 67 % of the variance explained by our model. We have identified the components of the fire, vegetation, and microclimate feedback that control where fires stop under current conditions, but their control should not be considered absolute. For example, when ignited in savanna, prescribed burns continued through wetland vegetation 43 % of the time. The feedback operating within these systems may be relatively weak as compared to other savanna systems. Environmental changes may alter fire spread extent, and with it ecosystem boundaries, or even ecosystem states.
C1 [Just, Michael G.; Hoffmann, William A.] N Carolina State Univ, Dept Plant & Microbial Biol, Raleigh, NC 27695 USA.
[Hohmann, Matthew G.] US Army, Corps Engineers, Engineer Res & Dev Ctr, POB 9005, Champaign, IL 61826 USA.
RP Just, MG (reprint author), N Carolina State Univ, Dept Plant & Microbial Biol, Raleigh, NC 27695 USA.
EM mjust@ncsu.edu
OI Just, Michael/0000-0003-2493-9269
FU US Army Engineer Research and Development Center [W9132T-11-2-0007];
North Carolina State University [W9132T-11-2-0007]; Southeast Climate
Science Center fellowship
FX We thank A. Ballard, S. Bell, B. Breslow, K. Fraboni, S. Goyette, R.
Sanders, M. Walz, and A. Whitehead for research assistance. We also
thank the Fort Bragg Endangered Species and Forestry branches for
logistic support. This research was supported by a cooperative agreement
between the US Army Engineer Research and Development Center and North
Carolina State University (W9132T-11-2-0007 to W.A.H.). M.G.J. received
support from a Southeast Climate Science Center fellowship.
NR 72
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U1 22
U2 29
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1385-0237
EI 1573-5052
J9 PLANT ECOL
JI Plant Ecol.
PD JUN
PY 2016
VL 217
IS 6
BP 631
EP 644
DI 10.1007/s11258-015-0545-x
PG 14
WC Plant Sciences; Ecology; Forestry
SC Plant Sciences; Environmental Sciences & Ecology; Forestry
GA DQ4IH
UT WOS:000379166900004
ER
PT J
AU Pasco, TE
Kaller, MD
Harlan, R
Kelso, WE
Rutherford, DA
Roberts, S
AF Pasco, T. E.
Kaller, M. D.
Harlan, R.
Kelso, W. E.
Rutherford, D. A.
Roberts, S.
TI Predicting Floodplain Hypoxia in the Atchafalaya River, Louisiana, USA,
a Large, Regulated Southern Floodplain River System
SO RIVER RESEARCH AND APPLICATIONS
LA English
DT Article
DE hypoxia; Atchafalaya River; flood pulse; general additive model;
floodplain
ID AQUATIC HABITAT CHARACTERISTICS; MURRAY-DARLING BASIN; FISH ASSEMBLAGES;
WATER-QUALITY; TEMPERATE FLOODPLAIN; NUTRIENT LIMITATION; COMMUNITY
STRUCTURE; APALACHICOLA RIVER; BLACKWATER EVENT; FLOW REGULATION
AB The Atchafalaya River Basin Floodway (ARBF), a regulated river/floodplain distributary of the Mississippi River, experiences an annual flood pulse that strongly influences floodplain physicochemistry. We developed several metrics to investigate the relationship between the timing and magnitude of the flood pulse and floodplain hypoxia, which in most years is a spatially extensive and temporally prolonged problem in the lower ARBF. Principal components analysis of flood metrics from 2001 to 2009 revealed contrasting flood types (early cool and late warm), but component-based general linear models were unable to predict the magnitude of hypoxia in ARBF water management areas (WMAs). Further analyses based on temperature and geographic information system-determined WMA inundation with generalized additive models (GAMs) revealed WMA-specific patterns of hypoxia, but the likelihood of hypoxia consistently increased when temperatures approached 20 degrees C and inundation rose above 20-30%. Validation with held-out data based on logistic regression indicated that the models constructed with the 2001-2009 temperature and inundation data were able to accurately predict the probabilities of hypoxia in two WMAs based on data collected from 2010 to 2013. The GAMs were an effective tool for visualizing and predicting the probability of hypoxia based on two easily generated parameters. Our analyses indicate that modification of the Atchafalaya River flood pulse could reduce the magnitude of hypoxia within the lower ARBF, subject to engineering (control structure operation) and economic (commercial fisheries production) constraints, by minimizing floodplain inundation after water temperatures reach 20 degrees C. Copyright (c) 2015 John Wiley & Sons, Ltd.
C1 [Pasco, T. E.; Kaller, M. D.; Harlan, R.; Kelso, W. E.; Rutherford, D. A.] Louisiana State Univ, Ctr Agr, Sch Renewable Nat Resources, Baton Rouge, LA 70803 USA.
[Roberts, S.] US Army Corps Engineers, New Orleans Dist, New Orleans, LA USA.
RP Pasco, TE (reprint author), Louisiana State Univ, Ctr Agr, Sch Renewable Nat Resources, Baton Rouge, LA 70803 USA.
EM tpasco1@lsu.edu
FU U.S. Army Corps of Engineers
FX The authors thank the U.S. Army Corps of Engineers for funding and Matt
Engel, Brian Heimann, Daniel Hill, Kayla Kimmel, Michael Krumrine, Jerry
Lang, Paula Tate, Tory Mason, Alex Perrett, Adam Piehler, Aaron Podey,
Rachel Walley, and Angela Williamson with their help in data collection.
Any use of trade, firm, or product names is for descriptive purposes
only and does not imply endorsement by the US Government. This
manuscript was approved for publication by the Director of the Louisiana
Agricultural Experiment Station as manuscript 2014-241-18859.
NR 68
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U1 2
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1535-1459
EI 1535-1467
J9 RIVER RES APPL
JI River Res. Appl.
PD JUN
PY 2016
VL 32
IS 5
BP 845
EP 855
DI 10.1002/rra.2903
PG 11
WC Environmental Sciences; Water Resources
SC Environmental Sciences & Ecology; Water Resources
GA DP7YQ
UT WOS:000378715500003
ER
PT J
AU Tiffan, KF
Hatten, JR
Trachtenbarg, DA
AF Tiffan, K. F.
Hatten, J. R.
Trachtenbarg, D. A.
TI Y Assessing Juvenile Salmon Rearing Habitat and Associated Predation
Risk in a Lower Snake River Reservoir
SO RIVER RESEARCH AND APPLICATIONS
LA English
DT Article
DE habitat; fall Chinook salmon; smallmouth bass; Snake River; modelling;
predation; riprap; Lower Granite Reservoir
ID FALL CHINOOK SALMON; SMALLMOUTH BASS; COLUMBIA RIVER; FISH COMMUNITIES;
MOVEMENT; CONSTRUCTION; IMPOUNDMENTS; HATCHERY; SYSTEM; REACH
AB Subyearling fall Chinook salmon (Oncorhynchustshawytscha) in the Columbia River basin exhibit a transient rearing strategy and depend on connected shoreline habitats during freshwater rearing. Impoundment has greatly reduced the amount of shallow-water rearing habitat that is exacerbated by the steep topography of reservoirs. Periodic dredging creates opportunities to strategically place spoils to increase the amount of shallow-water habitat for subyearlings while at the same time reducing the amount of unsuitable area that is often preferred by predators. We assessed the amount and spatial arrangement of subyearling rearing habitat in Lower Granite Reservoir on the Snake River to guide future habitat improvement efforts. A spatially explicit habitat assessment was conducted using physical habitat data, two-dimensional hydrodynamic modelling and a statistical habitat model in a geographic information system framework. We used field collections of subyearlings and a common predator [smallmouth bass (Micropterusdolomieu)] to draw inferences about predation risk within specific habitat types. Most of the high-probability rearing habitat was located in the upper half of the reservoir where gently sloping landforms created low lateral bed slopes and shallow-water habitats. Only 29% of shorelines were predicted to be suitable (probability >0.5) for subyearlings, and the occurrence of these shorelines decreased in a downstream direction. The remaining, less suitable areas were composed of low-probability habitats in unmodified (25%) and riprapped shorelines (46%). As expected, most subyearlings were found in high-probability habitat, while most smallmouth bass were found in low-probability locations. However, some subyearlings were found in low-probability habitats, such as riprap, where predation risk could be high. Given their transient rearing strategy and dependence on shoreline habitats, subyearlings could benefit from habitat creation efforts in the lower reservoir where high-probability habitat is generally lacking. Published 2015. This article is a U.S. Government work and is in the public domain in the USA.
C1 [Tiffan, K. F.; Hatten, J. R.] US Geol Survey, Western Fisheries Res Ctr, 5501A Cook Underwood Rd, Cook, WA 98605 USA.
[Trachtenbarg, D. A.] US Army, Corps Engineers, Walla Walla, WA USA.
RP Tiffan, KF (reprint author), US Geol Survey, Western Fisheries Res Ctr, 5501A Cook Underwood Rd, Cook, WA 98605 USA.
EM ktiffan@usgs.gov
OI Tiffan, Kenneth/0000-0002-5831-2846
FU US Army Corps of Engineers [W68SBV02850847]
FX We thank our US Geological Survey colleagues, in particular, Tom Batt,
Matt Sholtis, Scott St. John, Brad Bickford, Tobyn Rhodes and John
Erhardt, whose efforts contributed to this study. The constructive
comments of anonymous reviewers improved this manuscript. This study was
funded by the US Army Corps of Engineers under contract W68SBV02850847.
Any use of trade, firm or product names is for descriptive purposes only
and does not imply endorsement by the US government.
NR 41
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U1 3
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1535-1459
EI 1535-1467
J9 RIVER RES APPL
JI River Res. Appl.
PD JUN
PY 2016
VL 32
IS 5
BP 1030
EP 1038
DI 10.1002/rra.2934
PG 9
WC Environmental Sciences; Water Resources
SC Environmental Sciences & Ecology; Water Resources
GA DP7YQ
UT WOS:000378715500020
ER
PT J
AU Rotunno, E
Fabbri, F
Cinquanta, E
Kaplan, D
Longo, M
Lazzarini, L
Molle, A
Swaminathan, V
Salviati, G
AF Rotunno, E.
Fabbri, F.
Cinquanta, E.
Kaplan, D.
Longo, M.
Lazzarini, L.
Molle, A.
Swaminathan, V.
Salviati, G.
TI Structural, optical and compositional stability of MoS2 multi-layer
flakes under high dose electron beam irradiation
SO 2D MATERIALS
LA English
DT Article
DE molybdenum disulfide; cathodoluminescence; electron irradiation;
transmission electron microscopy; material encapsulation
ID LIGHT-EMITTING-DIODES; RADIATION-DAMAGE; MONOLAYER MOS2; GRAPHENE;
PHOTOLUMINESCENCE; MICROSCOPY
AB MoS2 multi-layer flakes, exfoliated from geological molybdenite, have been exposed to high dose electron irradiation showing clear evidence of crystal lattice and stoichiometry modifications. A massive surface sulfur depletion is induced together with the consequent formation of molybdenum nanoislands. It is found that a nanometric amorphous carbon layer, unwillingly deposited during the transmission electron microscope experiments, prevents the formation of the nanoislands. In the absence of the carbon layer, the formation of molybdenum grains proceeds both on the top and bottom surfaces of the flake. If carbon is present on both the surfaces then the formation ofMograins is completely prevented.
C1 [Rotunno, E.; Fabbri, F.; Lazzarini, L.; Salviati, G.] IMEM CNR Inst, Parco Area Sci 37-A, I-43124 Parma, Italy.
[Cinquanta, E.; Longo, M.; Molle, A.] IMM CNR, Lab MDM, Agrate Brianza, Italy.
[Kaplan, D.; Swaminathan, V.] US Army RDECOM ARDEC, Fuze Precis Armaments & Technol Directorate, Picatinny Arsenal, NJ USA.
RP Fabbri, F (reprint author), IMEM CNR Inst, Parco Area Sci 37-A, I-43124 Parma, Italy.
EM filippo.fabbri@imem.cnr.it
RI lazzarini, laura/B-7009-2015; Longo, Massimo/G-8893-2013
OI lazzarini, laura/0000-0001-5346-4026; Longo, Massimo/0000-0002-6364-8184
FU US Army [W911NF-14-1-0612]
FX The authors want to thank the economical support of US Army by means of
the contract W911NF-14-1-0612.
NR 28
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U1 17
U2 23
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 2053-1583
J9 2D MATER
JI 2D Mater.
PD JUN
PY 2016
VL 3
IS 2
AR 025024
DI 10.1088/2053-1583/3/2/025024
PG 7
WC Materials Science, Multidisciplinary
SC Materials Science
GA DP5XL
UT WOS:000378571400044
ER
PT J
AU Wang, GX
Slough, WJ
Pandey, R
Karna, SP
AF Wang, Gaoxue
Slough, William J.
Pandey, Ravindra
Karna, Shashi P.
TI Degradation of phosphorene in air: understanding at atomic level
SO 2D MATERIALS
LA English
DT Article
DE phosphorene; degradation; density functional theory; first principles
molecular dynamics
ID EXFOLIATED BLACK PHOSPHORUS; MOLECULAR-DYNAMICS; PHOTOOXIDATION;
ELECTRONICS; TRANSISTORS; DEFECTS; DENSITY; METALS; SET
AB Phosphorene is a promising two-dimensional (2D) material with a direct band gap, high carrier mobility, and anisotropic electronic properties. Phosphorene-based electronic devices, however, are found to degrade upon exposure to air. In this paper, we provide an atomic level understanding of the stability of phosphorene in terms of its interaction with O-2 and H2O. The results based on density functional theory together with first principles molecular dynamics calculations show that O-2 could the spontaneously dissociate on phosphorene at room temperature. H2O will not strongly interact with pristine phosphorene, however, an exothermic reaction could occur if phosphorene is first oxidized. The pathway of oxidation first, followed by exothermic reaction with water is the most likely route for the chemical degradation of phosphorene-based devices in air.
C1 [Wang, Gaoxue; Slough, William J.; Pandey, Ravindra] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA.
[Karna, Shashi P.] US Army Res Lab, Weap & Mat Res Directorate, ATTN RDRL WM, Aberdeen Proving Ground, MD 21005 USA.
RP Pandey, R (reprint author), Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA.
EM pandey@mtu.edu
RI Wang, Gaoxue/C-9492-2017
OI Wang, Gaoxue/0000-0003-2539-3405
FU ARL [W911NF-14-2-0088]
FX Helpful discussions with Dr V Swaminathan and S Gowtham are
acknowledged. Financial support from ARL W911NF-14-2-0088 is obtained.
RAMA and Superior, high performance computing clusters at Michigan
Technological University, were used in obtaining results presented in
this paper.
NR 34
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U1 32
U2 61
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 2053-1583
J9 2D MATER
JI 2D Mater.
PD JUN
PY 2016
VL 3
IS 2
AR 025011
DI 10.1088/2053-1583/3/2/025011
PG 7
WC Materials Science, Multidisciplinary
SC Materials Science
GA DP5XL
UT WOS:000378571400031
ER
PT J
AU Hausner, MB
Wilson, KP
Gaines, DB
Suarez, F
Scoppettone, GG
Tyler, SW
AF Hausner, Mark B.
Wilson, Kevin P.
Gaines, D. Bailey
Suarez, Francisco
Scoppettone, G. Gary
Tyler, Scott W.
TI Projecting the effects of climate change and water management on Devils
Hole pupfish (Cyprinodon diabolis) survival
SO ECOHYDROLOGY
LA English
DT Article
DE Devils Hole; climate change; conservation; computational fluid dynamics;
water management
ID AQUATIC ECOSYSTEM; NEVADENSIS; HABITAT; NEVADA; CARBON
AB Aquatic ecosystems of North American deserts are frequently very restricted in area and tend to harbour very specialized species endemic to their restricted habitats. Small changes in environmental conditions of these specialized forms may jeopardize their persistence. A notable example of endemic and specialized species that may have been influenced by slight changes in its habitat is the Devils Hole pupfish (Cyprinodon diabolis), which occurs only in a small pool ecosystem in the Mojave Desert of the Southwestern United States. In this study, we use a computational fluid dynamic (CFD) model to examine the physical effects of climate change and local groundwater management on Devils Hole and combine those results with a conceptual ecological model to consider the impacts of those changes on annual recruitment of C.diabolis. The CFD model predicts water temperatures as a response to climate and water level, and the ecological model is used to determine the timing of tipping points that may encourage or suppress the annual recruitment of C.diabolis. The combination of interdisciplinary modelling approaches offers a method to quantify and compare the suitability of habitat under a range of management and climate scenarios. Our results show that the influence of water level on peak temperatures in Devils Hole (and on the ecosystem's suitability for C.diabolis) is an order of magnitude greater than the influence of climate change. Copyright (c) 2015 John Wiley & Sons, Ltd.
C1 [Hausner, Mark B.; Tyler, Scott W.] Univ Nevada, Dept Geol Sci & Engn, MS 172, Reno, NV 89557 USA.
[Hausner, Mark B.; Suarez, Francisco] Pontificia Univ Catolica Chile, Dept Ingn Hidraul & Ambiental, Ave Vicuna Mackenna 4860, Santiago, Chile.
[Hausner, Mark B.] Desert Res Inst, Div Hydrol Sci, 755 East Flamingo Rd, Las Vegas, NV 89119 USA.
[Wilson, Kevin P.; Gaines, D. Bailey] Death Valley Natl Pk, Pahrump Field Off, 1321 So Hwy 160,Suite 1, Pahrump, NV 89048 USA.
[Gaines, D. Bailey] US Army Corps Engineers, Whitney Lake Off, 285 CR 3602, Clifton, TX 76634 USA.
[Scoppettone, G. Gary] US Geol Survey, Western Fisheries Res Ctr, Reno, NV USA.
RP Hausner, MB (reprint author), Div Hydrol Sci, 755 East Flamingo Rd, Las Vegas, NV 89119 USA.
EM mark.hausner@dri.edu
FU Sulo and Aileen Maki Endowment
FX The authors thank Sachiko Sueki and an anonymous reviewer for their
thoughtful and constructive comments on the manuscript. This research
was made possible by the Death Valley Natural History Association, the
Nevada Department of Wildlife, US National Park Service grant
J8R07090002, NSF-EAR-0929638, NSF-EAR-1128999, the Pontificia
Universidad Catolica de Chile School of Engineering, and the generosity
and support of the Sulo and Aileen Maki Endowment. We acknowledge the
World Climate Research Programme's Working Group on Coupled Modelling,
which is responsible for CMIP, and we thank the climate modelling groups
(listed in Table I of this paper) for producing and making available
their model output. For CMIP, the U.S. Department of Energy's Program
for Climate Model Diagnosis and Intercomparison provides coordinating
support and led development of software infrastructure in partnership
with the Global Organization for Earth System Science Portals. The
authors would like to dedicate this work to the memory of Dr Jim Deacon,
who was a tireless voice for the conservation of desert fishes and the
Devils Hole pupfish in particular. The views expressed in this article
are those of the authors and do not necessarily reflect any positions of
the United States government.
NR 40
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U1 16
U2 18
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1936-0584
EI 1936-0592
J9 ECOHYDROLOGY
JI Ecohydrology
PD JUN
PY 2016
VL 9
IS 4
BP 560
EP 573
DI 10.1002/eco.1656
PG 14
WC Ecology; Environmental Sciences; Water Resources
SC Environmental Sciences & Ecology; Water Resources
GA DP5PS
UT WOS:000378550200002
ER
PT J
AU Huh, J
Easley, ME
Nunley, JA
AF Huh, Jeannie
Easley, Mark E.
Nunley, James A., II
TI Characterization and Surgical Management of Achilles Tendon Sleeve
Avulsions
SO FOOT & ANKLE INTERNATIONAL
LA English
DT Article
DE Achilles rupture; sleeve avulsion; suture anchor; insertional
tendinopathy
ID TRANSCALCANEAL SUTURE TECHNIQUE; CALCANEAL TUBEROSITY; FRACTURES;
REPAIR; RUPTURE; ANATOMY; BONE; TIP
AB Background: An Achilles sleeve avulsion occurs when the tendon ruptures distally from its calcaneal insertion as a continuous sleeve. This relatively rare injury pattern may not be appreciated until the time of surgery and can be challenging to treat because, unlike a midsubstance rupture, insufficient tendon remains on the calcaneus to allow for end-to-end repair, and unlike a tuberosity avulsion fracture, any bony element avulsed with the tendon is inadequate for internal fixation. This study aimed to highlight the characteristics of Achilles sleeve avulsions and present the outcomes of operative repair using suture anchor fixation.
Methods: A retrospective analysis was conducted on 11 consecutive Achilles tendon sleeve avulsions (10 males, 1 female; mean age 44 years) that underwent operative repair between 2008 and 2014. Patient demographics, injury presentation, and operative details were reviewed. Postoperative outcomes were collected at a mean follow-up of 38.4 (range, 12-83.5) months, including the American Orthopaedic Foot & Ankle Society (AOFAS) Ankle-Hindfoot score, visual analog scale (VAS) for pain, plantarflexion strength, patient satisfaction, and complications.
Results: Eight patients (72.7%) had preexisting symptoms of insertional Achilles disease. Ten of 11 (90.9%) injuries were sustained during recreational athletic activity. An Achilles sleeve avulsion was recognized preoperatively in 7 of 11 (64%) cases, where lateral ankle radiographs demonstrated a small radiodensity several centimeters proximal to the calcaneal insertion. Intraoperatively, 90.9% of sleeve avulsions had a concomitant Haglund deformity and macroscopic evidence of insertional tendinopathy. All patients healed after suture anchor repair. The average AOFAS score was 92.8 and VAS score was 0.9. Ten patients (90.9%) were completely satisfied. One complication occurred, consisting of delayed wound healing.
Conclusions: Achilles tendon sleeve avulsions predominantly occurred in middle-aged men with preexisting insertional disease, while engaged in athletic activity. Suture anchor fixation, combined with addressing concomitant insertional pathology, was a reliable and safe technique for the operative management of Achilles tendon sleeve avulsions. The majority of patients returned to their preinjury levels of work and recreational activity.
Level of Evidence: Level IV, retrospective case series.
C1 [Huh, Jeannie] Dwight D Eisenhower Army Med Ctr, Dept Orthopaed Surg, 300 East Hosp Rd, Ft Gordon, GA 30905 USA.
[Easley, Mark E.; Nunley, James A., II] Duke Univ, Med Ctr, Dept Orthopaed Surg, Durham, NC USA.
RP Huh, J (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Orthopaed Surg, 300 East Hosp Rd, Ft Gordon, GA 30905 USA.
EM jhandyh@gmail.com
NR 31
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U1 0
U2 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1071-1007
EI 1944-7876
J9 FOOT ANKLE INT
JI Foot Ankle Int.
PD JUN
PY 2016
VL 37
IS 6
BP 596
EP 604
DI 10.1177/1071100716629778
PG 9
WC Orthopedics
SC Orthopedics
GA DP3WC
UT WOS:000378425600005
PM 26843543
ER
PT J
AU Eichinger, JK
Galvin, JW
Grassbaugh, JA
Parada, SA
Li, XN
AF Eichinger, Josef K.
Galvin, Joseph W.
Grassbaugh, Jason A.
Parada, Stephen A.
Li, Xinning
TI Glenoid Dysplasia Pathophysiology, Diagnosis, and Management
SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
LA English
DT Review
ID POSTERIOR SHOULDER INSTABILITY; BONE BLOCK PROCEDURE; HUMERAL HEAD
SUBLUXATION; GLENOHUMERAL JOINT; OSTEOARTHRITIS SECONDARY;
COMPUTED-TOMOGRAPHY; SURGICAL-TREATMENT; JERK TEST; RECURRENT;
HYPOPLASIA
C1 [Eichinger, Josef K.; Galvin, Joseph W.; Grassbaugh, Jason A.] Madigan Army Med Ctr, Tacoma, WA 98431 USA.
[Parada, Stephen A.] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA USA.
Boston Univ, Sch Med, Boston, MA 02118 USA.
[Li, Xinning] Boston Univ, Sch Med, Boston Med Ctr, Boston, MA 02118 USA.
RP Eichinger, JK (reprint author), Madigan Army Med Ctr, Tacoma, WA 98431 USA.
EM joe.eichinger@gmail.com; Joseph.w.galvin@gmail.com;
grassbaugh@gmail.com; stephen.a.parada@gmail.com; Xinning.li@gmail.com
NR 72
TC 0
Z9 0
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0021-9355
EI 1535-1386
J9 J BONE JOINT SURG AM
JI J. Bone Joint Surg.-Am. Vol.
PD JUN 1
PY 2016
VL 98
IS 11
BP 958
EP 968
DI 10.2106/JBJS.15.00916
PG 11
WC Orthopedics; Surgery
SC Orthopedics; Surgery
GA DP6ZK
UT WOS:000378648500014
PM 27252441
ER
PT J
AU Getz, TM
Montgomery, RK
Bynum, JA
Aden, JK
Pidcoke, HF
Cap, AP
AF Getz, Todd M.
Montgomery, Robbie K.
Bynum, James A.
Aden, James K.
Pidcoke, Heather F.
Cap, Andrew P.
TI Storage of platelets at 4 degrees C in platelet additive solutions
prevents aggregate formation and preserves platelet functional responses
SO TRANSFUSION
LA English
DT Article
ID COAT-DERIVED PLATELETS; FRESH WHOLE-BLOOD; 4 DEGREES-C; IN-VITRO;
APHERESIS PLATELETS; COLD; REFRIGERATION; TRANSFUSION; TEMPERATURE;
VIABILITY
AB BACKGROUNDPlatelet (PLT) storage has been limited to 5 days at room temperature due to metabolic decline and risk for bacterial contamination. Refrigeration preserves PLT metabolism and function as well as limits bacterial growth; however, cold storage of PLTs also leads to aggregate formation. We hypothesized that storage of PLT concentrates at 4 degrees C leads to glycoprotein (GP)IIb-IIIa activation and thus aggregate formation through fibrinogen binding and that this could be prevented by storing PLTs in PLT additive solution (PAS) without compromising PLT function.
STUDY DESIGN AND METHODSApheresis PLTs in plasma (AP) or apheresis PLTs in PAS were stored at 22 or 4 degrees C for up to 15 days. Measurements include PLT counts, blood gases, aggregation response, flow cytometry analysis of integrin levels, activation markers, and microparticle formation.
RESULTSStorage of AP 4 degrees C led to a gradual decline in PLT count and an increase in aggregate formation that was mediated by intracellular calcium leak and fibrinogen receptor activation. Storage of PAS at 4 degrees C prevented aggregate formation due to dilution of plasma fibrinogen. PAS stored at 4 degrees C maintained aggregation responses to multiple agonists better than 22 degrees C controls.
CONCLUSIONStorage of AP at 4 degrees C leads to low level GPIIb-IIIa activation and results in aggregate formation over time. Separating the PLTs from the plasma component and storing them in PAS at 4 degrees C resolves aggregate formation and preserves the metabolic and functional responses of these stored PLTs.
C1 [Getz, Todd M.; Montgomery, Robbie K.; Bynum, James A.; Aden, James K.; Pidcoke, Heather F.; Cap, Andrew P.] US Army, Inst Surg Res, San Antonio, TX USA.
RP Cap, AP (reprint author), US Army, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.
EM andrew.p.cap.mil@mail.mil
FU US Army Medical Research Materiel Command
FX Supported by the US Army Medical Research Materiel Command.
NR 38
TC 3
Z9 3
U1 0
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0041-1132
EI 1537-2995
J9 TRANSFUSION
JI Transfusion
PD JUN
PY 2016
VL 56
IS 6
BP 1320
EP 1328
DI 10.1111/trf.13511
PG 9
WC Hematology
SC Hematology
GA DP5QU
UT WOS:000378553200041
PM 26853912
ER
PT J
AU Kuhn, JH
Wiley, MR
Rodriguez, SE
Bao, YM
Prieto, K
da Rosa, APAT
Guzman, H
Savji, N
Ladner, JT
Tesh, RB
Wada, J
Jahrling, PB
Bente, DA
Palacios, G
AF Kuhn, Jens H.
Wiley, Michael R.
Rodriguez, Sergio E.
Bao, Yiming
Prieto, Karla
da Rosa, Amelia P. A. Travassos
Guzman, Hilda
Savji, Nazir
Ladner, Jason T.
Tesh, Robert B.
Wada, Jiro
Jahrling, Peter B.
Bente, Dennis A.
Palacios, Gustavo
TI Genomic Characterization of the Genus Nairovirus (Family Bunyaviridae)
SO VIRUSES-BASEL
LA English
DT Article
DE Bunyaviridae; bunyavirus; nairovirus; Dera Ghazi Khan virus; Erve virus;
Ganjam virus; Hughes virus; Qalyub virus; Sakhalin virus; Tunis virus;
virus classification; virus taxonomy
ID HEMORRHAGIC-FEVER-VIRUS; TICK-BORNE PHLEBOVIRUSES; HIDDEN MARKOV MODEL;
PHYLOGENETIC CHARACTERIZATION; SAKHALIN-GROUP; GENETIC-CHARACTERIZATION;
SEGMENT REASSORTMENT; ORNITHODOROS TICKS; SPECIES COMPLEX; IXODES-URIAE
AB Nairovirus, one of five bunyaviral genera, includes seven species. Genomic sequence information is limited for members of the Dera Ghazi Khan, Hughes, Qalyub, Sakhalin, and Thiafora nairovirus species. We used next-generation sequencing and historical virus-culture samples to determine 14 complete and nine coding-complete nairoviral genome sequences to further characterize these species. Previously unsequenced viruses include Abu Mina, Clo Mor, Great Saltee, Hughes, Raza, Sakhalin, Soldado, and Tillamook viruses. In addition, we present genomic sequence information on additional isolates of previously sequenced Avalon, Dugbe, Sapphire II, and Zirqa viruses. Finally, we identify Tunis virus, previously thought to be a phlebovirus, as an isolate of Abu Hammad virus. Phylogenetic analyses indicate the need for reassignment of Sapphire II virus to Dera Ghazi Khan nairovirus and reassignment of Hazara, Tofla, and Nairobi sheep disease viruses to novel species. We also propose new species for the Kasokero group (Kasokero, Leopards Hill, Yogue viruses), the Ketarah group (Gossas, Issyk-kul, Keterah/soft tick viruses) and the Burana group (Wenzhou tick virus, Huangpi tick virus 1, Tacheng tick virus 1). Our analyses emphasize the sister relationship of nairoviruses and arenaviruses, and indicate that several nairo-like viruses (Shayang spider virus 1, Xinzhou spider virus, Sanxia water strider virus 1, South Bay virus, Wuhan millipede virus 2) require establishment of novel genera in a larger nairovirus-arenavirus supergroup.
C1 [Kuhn, Jens H.; Wada, Jiro; Jahrling, Peter B.] NIAID, Integrated Res Facil Ft Detrick, Div Clin Res, NIH, Frederick, MD 21702 USA.
[Wiley, Michael R.; Prieto, Karla; Ladner, Jason T.; Palacios, Gustavo] US Army, Ctr Genome Sci, Med Res Inst Infect Dis, Frederick, MD 21702 USA.
[Rodriguez, Sergio E.; da Rosa, Amelia P. A. Travassos; Guzman, Hilda; Tesh, Robert B.; Bente, Dennis A.] Univ Texas Med Branch, Dept Microbiol & Immunol, Inst Human Infect & Immun, Galveston Natl Lab, Galveston, TX 77555 USA.
[Bao, Yiming] NIH, Informat Engn Branch, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20892 USA.
[Savji, Nazir] NYU, Sch Med, New York, NY 10016 USA.
RP Palacios, G (reprint author), US Army, Ctr Genome Sci, Med Res Inst Infect Dis, Frederick, MD 21702 USA.
EM kuhnjens@mail.nih.gov; michael.r.wiley19.ctr@mail.mil;
seerodri@utmb.edu; bao@ncbi.nlm.nih.gov; karla.prieto.ctr@mail.mil;
aptravas@utmb.edu; hguzman@utmb.edu; nazir.savji@gmail.com;
jason.t.ladner.ctr@mail.mil; rtesh@utmb.edu; wadaj@mail.nih.gov;
jahrlingp@niaid.nih.gov; dabente@utmb.edu;
gustavo.f.palacios.ctr@mail.mil
RI Palacios, Gustavo/I-7773-2015;
OI Palacios, Gustavo/0000-0001-5062-1938; Kuhn, Jens H./0000-0002-7800-6045
FU Defense Threat Reduction Agency [1881290]; United States Department of
Defense, Defense Biological Products Assurance Office; US National
Institutes of Health (NIH) [HHSN272201000040I/HHSN27200004/D04];
Intramural Research Program of the NIH, National Library of Medicine;
Battelle Memorial Institute; US National Institute of Allergy and
Infectious Diseases (NIAID) [HHSN272200700016I]
FX The content of this publication does not necessarily reflect the views
or policies of the US Department of Health and Human Services, or the
institutions and companies affiliated with the authors. This work was
supported by the Defense Threat Reduction Agency #1881290, and the
United States Department of Defense, Defense Biological Products
Assurance Office. A.P.A.T.d.R., H.G., and R.B.T. were supported by US
National Institutes of Health (NIH) contract
HHSN272201000040I/HHSN27200004/D04. Y.B. was supported by the Intramural
Research Program of the NIH, National Library of Medicine. This work was
supported in part through Battelle Memorial Institute's prime contract
with the US National Institute of Allergy and Infectious Diseases
(NIAID) under Contract No. HHSN272200700016I. A Battelle employee
involved in this work is: J.W. A subcontractor to Battelle Memorial
Institute who performed this work is: J.H.K., an employee of Tunnell
Government Services, Inc. We thank Laura Bollinger (Battelle Memorial
Institute) for editing this manuscript.
NR 128
TC 2
Z9 2
U1 2
U2 10
PU MDPI AG
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1999-4915
J9 VIRUSES-BASEL
JI Viruses-Basel
PD JUN
PY 2016
VL 8
IS 6
AR 164
DI 10.3390/v8060164
PG 27
WC Virology
SC Virology
GA DP9WM
UT WOS:000378848600016
ER
PT J
AU Amidon, WH
Roden-Tice, M
Anderson, AJ
McKeon, RE
Shuster, DL
AF Amidon, W. H.
Roden-Tice, M.
Anderson, A. J.
McKeon, R. E.
Shuster, D. L.
TI Late Cretaceous unroofing of the White Mountains, New Hampshire, USA: An
episode of passive margin rejuvenation?
SO GEOLOGY
LA English
DT Article
ID LOW-TEMPERATURE THERMOCHRONOLOGY; FISSION-TRACK ANALYSIS; NORTHERN
NEW-ENGLAND; AFRICAN RIFT SYSTEM; SOUTHERN AFRICA; ATLANTIC; STRESS;
BRAZIL; REACTIVATION; EXHUMATION
AB The growing recognition that many passive margins have experienced periods of post-rift uplift has raised new questions about the nature of the tectonic processes that drive such uplift. The eastern North America margin is of particular interest because it is a classic Atlanticstyle margin that has long been suspected of tectonic rejuvenation, yet the timing of post-rift uplift events remains elusive. To address this question we present apatite U-Th/He and fission track ages from a 1300 m vertical transect in the White Mountains of New Hampshire (USA), including a 910-m-deep bore hole. Thermal modeling suggests a period of accelerated denudation from ca. 85 to 65 Ma. This timing is broadly similar to the timing of accelerated exhumation and compression on passive margins elsewhere in the Atlantic, raising the question of whether a common mechanism, such as a change in lateral stresses, changes in mantle convection, or climate change, could be responsible.
C1 [Amidon, W. H.; Anderson, A. J.] Middlebury Coll, Dept Geol, Middlebury, VT 05753 USA.
[Roden-Tice, M.] SUNY Coll Plattsburgh, Ctr Earth & Environm Sci, Plattsburgh, NY 12901 USA.
[McKeon, R. E.] US Army, Cold Reg Res & Engn Lab, Corps Engineers, Engineer Res & Dev Ctr, Hanover, NH 03755 USA.
[Shuster, D. L.] Univ Calif Berkeley, Dept Earth & Planetary Sci, Berkeley, CA 94720 USA.
RP Amidon, WH (reprint author), Middlebury Coll, Dept Geol, Middlebury, VT 05753 USA.
NR 39
TC 0
Z9 0
U1 3
U2 3
PU GEOLOGICAL SOC AMER, INC
PI BOULDER
PA PO BOX 9140, BOULDER, CO 80301-9140 USA
SN 0091-7613
EI 1943-2682
J9 GEOLOGY
JI Geology
PD JUN
PY 2016
VL 44
IS 6
BP 415
EP 418
DI 10.1130/G37429.1
PG 4
WC Geology
SC Geology
GA DP0TW
UT WOS:000378203600006
ER
PT J
AU Knox, J
AF Knox, Jeffrey
TI Epidemiology of spinal cord injury without radiographic abnormality in
children: a nationwide perspective
SO JOURNAL OF CHILDRENS ORTHOPAEDICS
LA English
DT Article
DE Sciwora; Trauma; Spinal cord injury; Epidemiology
ID YOUNG-CHILDREN; TRAUMA
AB Purpose To characterize the epidemiology and costs associated with spinal cord injury without radiographic abnormality (SCIWORA) based on patient age.
Methods An analysis of data complied for 2012 in the Healthcare Utilization Project KID database (HCUP-KID), which represents a nationwide database of pediatric admissions, was performed. An initial search identified all children diagnosed with SCIWORA based on International Classification of Diseases, 9th edition (ICD-9) codes. Only data on patients aged <18 years were included in the analysis. The associated codes were then searched to identify the cause of injury. Pertinent epidemiologic data were collected from the database, including age, gender, and racial group. Injury level and pattern were determined from the associated ICD-9 codes, as were associated injuries. Hospital data included length of stay, in-hospital mortality, total hospital charges, and primary payer. All data were compiled and stratified based on patient age into three groups: group 1, age 0-3 years; group 2, age 4-10 years; group 3, age 11-17 years. These data were compared using Student's t test and Chi-squared analyses.
Results A total of 297 patients were identified who met the inclusion criteria. There was a slight predominance of females among the youngest patients (53 %) with a significant dominance of males in the oldest group (72 %) (p < 0.001). The most common race among the patients studied was white (50 %) followed by Hispanic (14 %), Black (12 %), Asian/Pacific Islander (4 %), and Native American (1 %). Overall, the most common cause of injury was sports injuries, which were responsible for 122/297 (41 %) injuries, followed by motor vehicle collisions (26 %). Mechanisms of injury were significantly varied based on age group, with motor vehicle collisions the most common cause in the youngest two age groups and sports injuries the most common in the oldest age group (p < 0.05). The most common location injured was the cervical spine (46 %), with the upper cervical spine most commonly injured, particularly in the younger age groups. Additional injuries were found in 158/297 (53 %) of patients, and these were more common among younger patients. Head trauma was the most common associated injury in all age groups, but the highest rate was found the youngest age groups (p < 0.0001). The average hospital stay for all patients was 13 days, with longer stays seen in younger age groups (p < 0.05). In-hospital mortality was uncommon among these patients and occurred in only 6/297 (2 %) of patients. Hospital charges were highest in the younger age groups, with an average charge of $210,772 for those in the youngest age group, decreasing to $72,178 for those in group 3 (p < 0.0005). The most common payer was public insurance/medicaid in the youngest age group and private insurance in groups 2 and 3 (p < 0.0001).
Conclusions SCIWORA is an uncommon but potentially devastating injury in children. As with many pediatric injuries, this injury is heterogeneous between children of differing ages. This analysis of a nationwide series of children with such injuries identified significant differences in injury location, causes of injury, associated injuries, and hospital charges associated with this diagnosis.
C1 [Knox, Jeffrey] Tripler Army Med Ctr, Orthoped Surg Serv MCHK DSO, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
RP Knox, J (reprint author), Tripler Army Med Ctr, Orthoped Surg Serv MCHK DSO, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM jeffrey.b.knox.mil@mail.mil
NR 17
TC 0
Z9 0
U1 1
U2 1
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1863-2521
EI 1863-2548
J9 J CHILD ORTHOP
JI J. Child. Orthop.
PD JUN
PY 2016
VL 10
IS 3
BP 255
EP 260
DI 10.1007/s11832-016-0740-x
PG 6
WC Orthopedics
SC Orthopedics
GA DP0DX
UT WOS:000378159300012
PM 27209042
ER
PT J
AU Clemens, BJ
Spangler, JJ
Robertson, PL
Galovich, GM
Banner, CR
Gunckel, SL
Ketchum, LL
Bowden, RK
Spagnoli, ST
Kent, ML
Kirk, JP
AF Clemens, Benjamin J.
Spangler, John J.
Robertson, Paul L.
Galovich, Gary M.
Banner, Craig R.
Gunckel, Stephanie L.
Ketchum, Lindsay L.
Bowden, R. Kanani
Spagnoli, Sean T.
Kent, Michael L.
Kirk, James P.
TI Persistence of Triploid Grass Carp in Devils Lake, Oregon
SO JOURNAL OF FISH AND WILDLIFE MANAGEMENT
LA English
DT Article
DE Asian carp; gonadal histology; intersex; maximum age; sterile
ID BIGHEAD CARP; ESTABLISHMENT; RESERVOIRS; PRECISION; INTERSEX; RIVER; AGE
AB Grass carp Ctenopharyngodon idella are sometimes used as a biological tool for managing aquatic vegetation in reservoirs. Sterile, triploid fish were stocked in Devils Lake, Oregon, during 1986, 1987, and 1993 to control aquatic vegetation. We present a case study for using multiple measures on the same fish to determine whether illegal stocking of fertile, diploid grass carp occurred. An investigation into the estimated age of a dead grass carp found in Devils Lake suggested that it was significantly younger than would otherwise be expected, given the only stocking events occurred during 1986, 1987, and 1993. To determine whether illegal stocking or reproduction by presumed sterile grass carp had occurred in Devils Lake, we conducted a study that balanced the needs of lethally sampling grass carp for biological measures with the socially and politically sensitive sentiment of the pro-grass carp citizenry of Devils Lake. These considerations, in combination with a low catch per-unit effort, resulted in a modest sample size for grass carp. We sampled grass carp and recorded multiple measures for each fish. Ploidy testing of blood samples indicated the grass carp were all triploid. Based on gonadal histopathology, six fish were male, two were female, and two were sex-indeterminate with severe gonadal dysgenesis. Age estimates from lapillus otoliths were consistent with fish originating from the legal stocking events in Devils Lake. The grass carp were 21-30 y old, and we were unable to find published reports of grass carp anywhere else in the world that are older. The grass carp were significantly smaller than much younger fish from other regions. The small size of these grass carp relative to their age in Devils Lake suggests food limitations that stunted growth. The dead grass carp that was the impetus for this study was aged by anatomical structures that we have since found to be unreliable. This suggests that the dead grass carp was probably in fact older and originated from the legal stockings. The use of multiple biological measurements on a modest sample size of grass carp, combined with the knowledge that no juvenile grass carp have been observed since legal stocking occurred, lead us to conclude that the grass carp in Devils Lake are sterile fish that originated from legal stocking events.
C1 [Clemens, Benjamin J.; Gunckel, Stephanie L.; Ketchum, Lindsay L.; Bowden, R. Kanani] Oregon Dept Fish & Wildlife, 28655 Highway 34, Corvallis, OR 97333 USA.
[Spangler, John J.] Oregon Dept Fish & Wildlife, 810 SW Alder St,Unit C, Newport, OR 97365 USA.
[Robertson, Paul L.] Devils Lake Water Improvement Dist, POB 974, Lincoln City, OR 97367 USA.
[Galovich, Gary M.] Oregon Dept Fish & Wildlife, 4034 Fairview Ind Dr SE, Salem, OR 97302 USA.
[Banner, Craig R.] Oregon State Univ, Oregon Dept Fish & Wildlife, Corvallis, OR 97331 USA.
[Banner, Craig R.] Oregon State Univ, Dept Microbiol, Corvallis, OR 97331 USA.
[Spagnoli, Sean T.; Kent, Michael L.] Oregon State Univ, Dept Microbiol, Corvallis, OR 97331 USA.
[Kirk, James P.] Engn Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
RP Clemens, BJ (reprint author), Oregon Dept Fish & Wildlife, 28655 Highway 34, Corvallis, OR 97333 USA.
EM Ben.Clemens@oregonstate.edu
FU Oregon Department of Fish and Wildlife's Restoration and Enhancement
funds
FX Equipment used for processing fish tissues for age estimates was
procured through a grant from the Oregon Department of Fish and
Wildlife's Restoration and Enhancement funds. Use of trade names does
not constitute endorsement. M. Terwilliger provided technical guidance
and assistance, including a separate age estimation of the dead grass
carp that was the impetus for this study. B. Hickson of the Warm Springs
Fish Health Center (U.S. Fish and Wildlife Service) conducted ploidy
testing. D. Avery assisted with collection of fish. This manuscript
benefitted from the thorough reviews of two editors and three reviewers.
NR 29
TC 0
Z9 0
U1 7
U2 7
PU U S FISH & WILDLIFE SERVICE
PI SHEPHERDSTOWN
PA NATL CONSERVATION TRAINING CENTER, CONSERVATION LIBRARY, 698
CONSERVATION WAY, SHEPHERDSTOWN, WV 25443 USA
SN 1944-687X
J9 J FISH WILDL MANAG
JI J. Fish Wildl. Manag.
PD JUN
PY 2016
VL 7
IS 1
BP 153
EP 161
DI 10.3996/042015-JFWM-044
PG 9
WC Biodiversity Conservation; Ecology
SC Biodiversity & Conservation; Environmental Sciences & Ecology
GA DO9CT
UT WOS:000378082600014
ER
PT J
AU Glick, Y
Fromzel, V
Zhang, J
Dahan, A
Ter-Gabrielyan, N
Pattnaik, RK
Dubinskii, M
AF Glick, Yaakov
Fromzel, Viktor
Zhang, Jun
Dahan, Asaf
Ter-Gabrielyan, Nikolay
Pattnaik, Radha K.
Dubinskii, Mark
TI High power, high efficiency diode pumped Raman fiber laser
SO LASER PHYSICS LETTERS
LA English
DT Article
DE fiber laser; Raman laser; nonlinear optical fiber
ID MULTIMODE FIBER; AMPLIFIER; SPECTRUM
AB We demonstrate a high power high efficiency Raman fiber laser pumped directly by a laser diode module at 976 nm. 80 Watts of CW power were obtained at a wavelength of 1020 nm with an optical-to-optical efficiency of 53%. When working quasi-CW, at a duty cycle of 30%, 85 W of peak power was produced with an efficiency of 60%. A commercial graded-index (GRIN) core fiber acts as the Raman fiber in a power oscillator configuration, which includes spectral selection to prevent generation of the 2nd Stokes. In addition, significant brightness enhancement of the pump beam is attained due to the Raman gain distribution profile in the GRIN fiber. To the best of our knowledge, this is the highest power Raman fiber laser directly pumped by laser diodes, which also exhibits a record efficiency for such a laser. In addition, it is the highest power Raman fiber laser (regardless of pumping source) demonstrated based on a GRIN fiber.
C1 [Glick, Yaakov; Fromzel, Viktor; Zhang, Jun; Ter-Gabrielyan, Nikolay; Pattnaik, Radha K.; Dubinskii, Mark] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
[Glick, Yaakov; Dahan, Asaf] Soreq Nucl Res Ctr, Div Appl Phys, IL-81800 Yavne, Israel.
RP Glick, Y (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.; Glick, Y (reprint author), Soreq Nucl Res Ctr, Div Appl Phys, IL-81800 Yavne, Israel.
EM yaakovgl@soreq.gov.il
NR 18
TC 3
Z9 3
U1 4
U2 8
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 1612-2011
EI 1612-202X
J9 LASER PHYS LETT
JI Laser Phys. Lett.
PD JUN
PY 2016
VL 13
IS 6
AR 065101
DI 10.1088/1612-2011/13/6/065101
PG 6
WC Optics; Physics, Applied
SC Optics; Physics
GA DO7PR
UT WOS:000377975000006
ER
PT J
AU Singh, J
Haines, C
AF Singh, Jogender
Haines, Chris
TI FIELD ASSISTED SINTERING TECHNOLOGY UPDATE-PART II
SO ADVANCED MATERIALS & PROCESSES
LA English
DT Article
C1 [Singh, Jogender] Penn State Univ, FASM, University Pk, PA 16801 USA.
[Haines, Chris] US Army RDECOM ARDEC, Picatinny Arsenal, NJ USA.
RP Singh, J (reprint author), Penn State Univ, Dept Mat Sci & Engn, FAST Ctr Excellence, University Pk, PA 16801 USA.
EM jxs46@psu.edu
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ASM INT
PI MATERIALS PARK
PA SUBSCRIPTIONS SPECIALIST CUSTOMER SERVICE, MATERIALS PARK, OH 44073-0002
USA
SN 0882-7958
EI 2161-9425
J9 ADV MATER PROCESS
JI Adv. Mater. Process.
PD JUN
PY 2016
VL 174
IS 6
BP 22
EP 24
PG 3
WC Materials Science, Multidisciplinary
SC Materials Science
GA DO5UL
UT WOS:000377848200007
ER
PT J
AU Taylor, S
Messenger, S
Folco, L
AF Taylor, Susan
Messenger, Scott
Folco, Luigi
TI Cosmic Dust: Finding a Needle in a Haystack
SO ELEMENTS
LA English
DT Article
DE micrometeorites; interplanetary dust particles (IDP); polar collections;
stratospheric collections
ID TRANSANTARCTIC MOUNTAINS; ACCRETION RATE; BLUE ICE; MICROMETEORITES;
SPHERULES; ANTARCTICA; COLLECTION; DEBRIS; EARTH
AB Collecting cosmic dust is a tricky business! Despite Earth's surface being showered by thousands of tons of comic dust every year, such dust is quickly lost in a sea of terrestrial particles. Finding the tiny cosmic treasures requires collecting dust from the cleanest environments where the terrestrial particle background is low. The stratosphere can be sampled via high-flying aircraft, whereas sampling cosmic dust from polar regions and the deep sea requires techniques that concentrate the particles. Collection efforts are worth it. Cosmic dust derives from every dust-producing object in the Solar System, including ancient Solar System materials, possibly even interstellar materials, of a type not found in meteorites.
C1 [Taylor, Susan] US Army, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA.
[Messenger, Scott] NASA, Lyndon B Johnson Space Ctr, ARES, Houston, TX 77058 USA.
[Folco, Luigi] Univ Pisa, Dept Sci Terra, Pisa, Italy.
RP Taylor, S (reprint author), US Army, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA.
EM Susan.Taylor@erdc.dren.mil; scott.messenger@nasa.gov;
luigi.folco@unipi.it
NR 30
TC 4
Z9 4
U1 3
U2 3
PU MINERALOGICAL SOC AMER
PI CHANTILLY
PA 3635 CONCORDE PKWY STE 500, CHANTILLY, VA 20151-1125 USA
SN 1811-5209
EI 1811-5217
J9 ELEMENTS
JI Elements
PD JUN
PY 2016
VL 12
IS 3
BP 171
EP 176
DI 10.2113/gselements.12.3.171
PG 6
WC Geochemistry & Geophysics; Mineralogy
SC Geochemistry & Geophysics; Mineralogy
GA DO5UC
UT WOS:000377847300003
ER
PT J
AU Olmo, HR
Stokes, SM
Foss, RD
AF Olmo, Heather R.
Stokes, Steven Marc
Foss, Robert D.
TI Olfactory Neuroblastoma: A Case Report
SO HEAD & NECK PATHOLOGY
LA English
DT Article
DE Olfactory neuroblastoma; Nasal cavity; Paranasal sinuses; Radiology;
Homer Wright pseudorosettes; Flexner-Wintersteiner rosettes
ID SINONASAL UNDIFFERENTIATED CARCINOMA; NEURO-BLASTOMA;
ESTHESIONEUROBLASTOMA; NEOPLASMS; FEATURES
AB A 43-year-old female presented with persistent nasal congestion with intermittent epistaxis without resolution for the preceding 5 years. Clinical examination revealed a large pink rubbery mass, medial to the middle turbinate in the right nasal cavity extending to the choana. Radiographic images demonstrated a heterogeneously enhancing lobular soft tissue mass filling the right nasal cavity, causing lateral bowing of the right medial orbital wall and extending posteriorly to the right anterior ethmoid sinus. The clinical, radiographic, histologic, and immunohistochemical features of olfactory neuroblastoma are discussed.
C1 [Olmo, Heather R.] US Army, Off Surg Gen, Dent Corps, 7700 Arlington Blvd, Falls Church, VA 22042 USA.
[Stokes, Steven Marc] Bur Med & Surg, Off Strategy Management, 7700 Arlington Blvd, Falls Church, VA 22042 USA.
[Foss, Robert D.] Joint Pathol Ctr, Head & Neck Pathol, 606 Stephen Sitter Ave, Silver Spring, MD 20910 USA.
RP Olmo, HR (reprint author), US Army, Off Surg Gen, Dent Corps, 7700 Arlington Blvd, Falls Church, VA 22042 USA.
EM heather.r.olmo.mil@mail.mil; steven.m.stokes6.mil@mail.mil;
robert.d.foss.ctr@mail.mil
NR 15
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1936-055X
EI 1936-0568
J9 HEAD NECK PATHOL
JI Head Neck Pathol.
PD JUN
PY 2016
VL 10
IS 2
BP 256
EP 260
DI 10.1007/s12105-015-0649-6
PG 5
WC Pathology
SC Pathology
GA DO6KJ
UT WOS:000377891800025
PM 26316323
ER
PT J
AU Tompkins, RP
Khan, MR
Green, R
Jones, KA
Leach, JH
AF Tompkins, R. P.
Khan, M. R.
Green, R.
Jones, K. A.
Leach, J. H.
TI IVT measurements of GaN power Schottky diodes with drift layers grown by
HVPE on HVPE GaN substrates
SO JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
LA English
DT Article
ID CURRENT-VOLTAGE CHARACTERISTICS; N-TYPE GAN; THIN-FILMS; SI
AB To date, a majority of epitaxial layers for vertical gallium nitride (GaN) power Schottky diodes have been grown by metalorganic chemical vapor deposition. In this work, we investigate the electrical properties of vertical GaN Schottky diodes with drift layers grown by hydride vapor phase epitaxy (HVPE) on moderately-doped freestanding HVPE GaN substrates. Room temperature IV data is presented for devices tested where results for diode characteristics such as the breakdown voltage, V-b, specific on-resistance, Ron-sp, ideality factor, n, and barrier height, Phi(b), are measured for devices across the 1 cm 9 1 cm sample. The smallest diodes, which are 30 mu m in diameter, show the smallest specific on-resistance, whereas the breakdown voltage (defined as the voltage corresponding to a current of 10 mA cm(-2)) is independent of device size across the wafer. IV data show an average value of 1.06 +/- 0.06 for n and 0.80 +/- 0.04 eV for Phi(b) with little variation across the wafer, suggesting a reasonable metal-semiconductor interface across the entire sample. For one of the 300 mu m devices tested, we also examine the IV properties as function of temperature from 25 to 250 degrees C in increments of 25 degrees C and extract a zero temperature Phi(b) of 0.908 eV and Richardson's constant of 4.44 A cm(-2) K-2 which is significantly less than the theoretical value of 26.9 A cm(-2) K-2
C1 [Tompkins, R. P.; Khan, M. R.; Green, R.; Jones, K. A.] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
[Leach, J. H.] Kyma Technol, 8829 Midway West Rd, Raleigh, NC 27617 USA.
RP Tompkins, RP (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM randy.tompkins.civ@mail.mil
NR 27
TC 1
Z9 1
U1 9
U2 23
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0957-4522
EI 1573-482X
J9 J MATER SCI-MATER EL
JI J. Mater. Sci.-Mater. Electron.
PD JUN
PY 2016
VL 27
IS 6
BP 6108
EP 6114
DI 10.1007/s10854-016-4536-z
PG 7
WC Engineering, Electrical & Electronic; Materials Science,
Multidisciplinary; Physics, Applied; Physics, Condensed Matter
SC Engineering; Materials Science; Physics
GA DO6MQ
UT WOS:000377898000082
ER
PT J
AU Hurtgen, BJ
Ward, CL
Garg, K
Pollot, BE
Goldman, SM
McKinley, TO
Wenke, JC
Corona, BT
AF Hurtgen, B. J.
Ward, C. L.
Garg, K.
Pollot, B. E.
Goldman, S. M.
McKinley, T. O.
Wenke, J. C.
Corona, B. T.
TI Severe muscle trauma triggers heightened and prolonged local
musculoskeletal inflammation and impairs adjacent tibia fracture healing
SO JOURNAL OF MUSCULOSKELETAL & NEURONAL INTERACTIONS
LA English
DT Article
DE Skeletal Muscle Injury; Volumetric Muscle Loss; Trauma; Musculoskeletal;
Inflammation; Innate; Adaptive; Immune Response; Composite Injury
ID SKELETAL-MUSCLE; LOSS INJURY; FASCIOCUTANEOUS TISSUE;
MUSCULAR-DYSTROPHY; BONE REGENERATION; EXTREMITY TRAUMA; IMMUNE-SYSTEM;
T-CELLS; RATS; FIBROSIS
AB Objectives: Complicated fracture healing is often associated with the severity of surrounding muscle tissue trauma. Since inflammation is a primary determinant of musculoskeletal health and regeneration, it is plausible that delayed healing and non-unions are partly caused by compounding local inflammation in response to concomitant muscle trauma. Methods and results: To investigate this possibility, a Lewis rat open fracture model [tibia osteotomy with adjacent tibialis anterior (TA) muscle volumetric muscle loss (VML) injury] was interrogated. We observed that VML injury impaired tibia healing, as indicated by diminished mechanical strength and decreased mineralized bone within the fracture callus, as well as continued presence of cartilage instead of woven bone 28 days post-injury. The VML injured muscle presented innate and adaptive immune responses that were atypical of canonical muscle injury healing. Additionally, the VML injury resulted in a perturbation of the inflammatory phase of fracture healing, as indicated by elevations of CD3(+) lymphocytes and CD68(+) macrophages in the fracture callus at 3 and 14d post-injury, respectively. Conclusions: These data indicate that heightened and sustained innate and adaptive immune responses to traumatized muscle are associated with impaired fracture healing and may be targeted for the prevention of delayed and non-union following musculoskeletal trauma.
C1 [Hurtgen, B. J.; Ward, C. L.; Garg, K.; Pollot, B. E.; Goldman, S. M.; Wenke, J. C.; Corona, B. T.] US Army Inst Surg Res, Extrem Trauma & Regenerat Med Task Area, 3698 Chambers Pass,BHT1, Ft Sam Houston, TX 78234 USA.
[McKinley, T. O.] Indiana Univ Sch Med, Dept Orthopaed Surg, Indianapolis, IN 46202 USA.
RP Corona, BT (reprint author), US Army Inst Surg Res, Extrem Trauma & Regenerat Med Task Area, 3698 Chambers Pass,BHT1, Ft Sam Houston, TX 78234 USA.
EM benjamin.t.corona.vol@mail.mil
FU Combat Casualty Care Research Program, Medical Research and Materiel
Command; Orthopaedic Trauma Association
FX This work was supported by the Combat Casualty Care Research Program,
Medical Research and Materiel Command (BTC) and the Orthopaedic Trauma
Association (BTC & TOM). This work was performed as part of a service
obligation to the NIH-LRP (BTC). BJH and CLW were post-doctoral fellows
through the National Academy of Sciences during a portion of these
studies. We thank Dr. Lisa Ji and Ms. Monica Jalomo for their technical
assistance.
NR 56
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Z9 2
U1 2
U2 4
PU JMNI
PI NAFPLION
PA 7 SPILIADOU SQ, NAFPLION, 21 100, GREECE
SN 1108-7161
J9 J MUSCULOSKEL NEURON
JI J. Musculoskelet. Neuronal Interact.
PD JUN
PY 2016
VL 16
IS 2
BP 122
EP 134
PG 13
WC Neurosciences; Physiology
SC Neurosciences & Neurology; Physiology
GA DO5IF
UT WOS:000377816100005
PM 27282456
ER
PT J
AU Ponlawat, A
Kankaew, P
Chanaimongkol, S
Pongsiri, A
Richardson, JH
Evans, BP
AF Ponlawat, Alongkot
Kankaew, Prasan
Chanaimongkol, Somporn
Pongsiri, Arissara
Richardson, Jason H.
Evans, Brian P.
TI SEMI-FIELD EVALUATION OF METOFLUTHRIN-IMPREGNATED NETS ON HOST-SEEKING
AEDES AEGYPTI AND ANOPHELES DIRUS
SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION
LA English
DT Article
DE Aedes aegypti; Anopheles dirus; metofluthrin; mosquito control; spatial
repellent
ID SPATIAL REPELLENCY; FIELD-EVALUATION; PLASTIC STRIPS; MALARIA CONTROL;
ENTOMOLOGICAL EVALUATION; PERSONAL PROTECTION; EXPERIMENTAL HUTS;
MOSQUITO NETS; PAPER STRIP; INSECTICIDE
AB The efficacy of a metofluthrin-impregnated net (MIN) known as the "Mushikonazu" on the house entry behavior of female Aedes aegypti and Anopheles dirus mosquitoes was evaluated using a semi-field 50-m tunnel setup. While the MIN is labeled for the control of chironomids and moth flies, this study determined the feasibility of using the device, given its current construction and metofluthrin formulation, as a spatial repellent against mosquitoes. Sentinel and cone bioassays were used to determine the insecticidal effect of the MIN. A spatial activity index (SAI) was calculated to evaluate responses of the mosquitoes. For the spatial repellent evaluation against Ae. aegypti, the overall mean of SAI was slightly less than 0 at wk 1 after the MIN application and then decreased for the last 4 wk showing a preference to treatment tent. For An. dirus, the mean SAI at wk 1 was positive, indicating a presumed repellent effect of the MIN against An. dirus. For the subsequent 4 wk, the SAI was negative, indicating a preference for the MIN. Results suggested that the MIN may not be a promising approach to repel Ae. aegypti and An. dirus under field conditions in Thailand. However, it remains probable that the MIN may be effective as a spatial repellent if modifications are made to the metofluthrin concentration or formulation and/or the construction of the device.
C1 [Ponlawat, Alongkot; Kankaew, Prasan; Chanaimongkol, Somporn; Pongsiri, Arissara] Armed Forces Res Inst Med Sci AFRIMS, Dept Entomol, Bangkok 10400, Thailand.
[Richardson, Jason H.] Armed Forces Pest Management Board, Silver Spring, MD 20910 USA.
[Evans, Brian P.] US Army Med Dept Ctr & Sch, Environm Hlth Branch, San Antonio, TX 78234 USA.
RP Ponlawat, A (reprint author), Armed Forces Res Inst Med Sci AFRIMS, Dept Entomol, Bangkok 10400, Thailand.
FU Military Infectious Disease Research Program-Identification and Control
of Insect Vectors of Infectious Diseases (Task Area U)
FX We acknowledge the excellent support of Siriporn Phasomkusolsil and the
Insectary staff, Department of Entomology, Armed Forces Research
Institute of Medical Sciences. We thank John P. Grieco and Nicole L.
Achee, University of Notre Dame, for guidance and suggestions on the
experimental design. Also, we thank Ethan C. Degner from Cornell
University for editorial assistance. This work was financially supported
by the Military Infectious Disease Research Program-Identification and
Control of Insect Vectors of Infectious Diseases (Task Area U). The
views expressed herein are the private views of the authors and do not
reflect the official views of the United States Army or the United
States Department of Defense.
NR 32
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Z9 1
U1 0
U2 2
PU AMER MOSQUITO CONTROL ASSOC
PI MOUNT LAUREL
PA 15000 COMMERCE PARKWAY, SUITE C, MOUNT LAUREL, NJ 08054 USA
SN 8756-971X
EI 1943-6270
J9 J AM MOSQUITO CONTR
JI J. Am. Mosq. Control Assoc.
PD JUN
PY 2016
VL 32
IS 2
BP 130
EP 138
PG 9
WC Entomology
SC Entomology
GA DO3YD
UT WOS:000377717700007
PM 27280351
ER
PT J
AU Ross, JA
Richie, DA
Park, SJ
Shires, DR
AF Ross, James A.
Richie, David A.
Park, Song J.
Shires, Dale R.
TI Parallel programming model for the Epiphany many-core coprocessor using
threaded MPI
SO MICROPROCESSORS AND MICROSYSTEMS
LA English
DT Article
DE 2D RISC array; MPI; NoC; Many-core; Adapteva Epiphany; Energy efficiency
ID PROCESSOR; PERFORMANCE; ARCHITECTURES
AB The Adapteva Epiphany many-core architecture comprises a 2D tiled mesh Network-on-Chip (NoC) of low-power RISC cores with minimal uncore functionality. It offers high computational energy efficiency for both integer and floating point calculations as well as parallel scalability. Yet despite the interesting architectural features, a compelling programming model has not been presented to date. This paper demonstrates an efficient parallel programming model for the Epiphany architecture based on the Message Passing Interface (MPI) standard. Using MPI exploits the similarities between the Epiphany architecture and a conventional parallel distributed cluster of serial cores. Our approach enables MPI codes to execute on the RISC array processor with little modification and achieve high performance. We report benchmark results for the threaded MPI implementation of four algorithms (dense matrix-matrix multiplication, N-body particle interaction, five-point 2D stencil update, and 2D FFT) and highlight the importance of fast inter-core communication for the architecture. Published by Elsevier B.V.
C1 [Ross, James A.; Park, Song J.; Shires, Dale R.] US Army, Res Lab, Aberdeen Proving Ground, MD USA.
[Richie, David A.] Brown Deer Technol, Forest Hill, MD USA.
RP Ross, JA (reprint author), US Army, Res Lab, Aberdeen Proving Ground, MD USA.
EM james.a.ross176.civ@mail.mil; drichie@browndeertechnology.com;
song.j.park.civ@mail.mil; dale.r.shires.civ@mail.mil
FU U.S. Army Research Laboratory-hosted Department of Defense
Supercomputing Resource Center
FX The authors wish to acknowledge the U.S. Army Research Laboratory-hosted
Department of Defense Supercomputing Resource Center for its support of
this work.
NR 35
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Z9 0
U1 2
U2 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0141-9331
EI 1872-9436
J9 MICROPROCESS MICROSY
JI Microprocess. Microsyst.
PD JUN
PY 2016
VL 43
SI SI
BP 95
EP 103
DI 10.1016/j.micpro.2016.02.006
PG 9
WC Computer Science, Hardware & Architecture; Computer Science, Theory &
Methods; Engineering, Electrical & Electronic
SC Computer Science; Engineering
GA DO4GT
UT WOS:000377740500009
ER
PT J
AU Obodo, UC
Epum, EA
Platts, MH
Seloff, J
Dahlson, NA
Velkovsky, SM
Paul, SR
Friedman, KL
AF Obodo, Udochukwu C.
Epum, Esther A.
Platts, Margaret H.
Seloff, Jacob
Dahlson, Nicole A.
Velkovsky, Stoycho M.
Paul, Shira R.
Friedman, Katherine L.
TI Endogenous Hot Spots of De Novo Telomere Addition in the Yeast Genome
Contain Proximal Enhancers That Bind Cdc13
SO MOLECULAR AND CELLULAR BIOLOGY
LA English
DT Article
ID SACCHAROMYCES-CEREVISIAE TELOMERES; SINGLE-STRANDED-DNA; LENGTH
REGULATION; CHROMOSOME ENDS; IN-VITRO; PROTEIN; MAINTENANCE;
RECOMBINATION; RAP1P; IDENTIFICATION
AB DNA double-strand breaks (DSBs) pose a threat to genome stability and are repaired through multiple mechanisms. Rarely, telomerase, the enzyme that maintains telomeres, acts upon a DSB in a mutagenic process termed telomere healing. The probability of telomere addition is increased at specific genomic sequences termed sites of repair-associated telomere addition (SiRTAs). By monitoring repair of an induced DSB, we show that SiRTAs on chromosomes V and IX share a bipartite structure in which a core sequence (Core) is directly targeted by telomerase, while a proximal sequence (Stim) enhances the probability of de novo telomere formation. The Stim and Core sequences are sufficient to confer a high frequency of telomere addition to an ectopic site. Cdc13, a single-stranded DNA binding protein that recruits telomerase to endogenous telomeres, is known to stimulate de novo telomere addition when artificially recruited to an induced DSB. Here we show that the ability of the Stim sequence to enhance de novo telomere addition correlates with its ability to bind Cdc13, indicating that natural sites at which telomere addition occurs at high frequency require binding by Cdc13 to a sequence 20 to 100 bp internal from the site at which telomerase acts to initiate de novo telomere addition.
C1 [Obodo, Udochukwu C.; Epum, Esther A.; Platts, Margaret H.; Seloff, Jacob; Dahlson, Nicole A.; Velkovsky, Stoycho M.; Paul, Shira R.; Friedman, Katherine L.] Vanderbilt Univ, Dept Biol Sci, 221 Kirkland Hall, Nashville, TN 37235 USA.
[Platts, Margaret H.] Duke Univ, Durham, NC USA.
[Seloff, Jacob] US Mil Acad, New York, NY USA.
[Dahlson, Nicole A.] UT Southwestern Med Ctr, Dallas, TX USA.
[Velkovsky, Stoycho M.] SUNY Stony Brook, Dept Ecol & Evolut, Stony Brook, NY 11794 USA.
[Paul, Shira R.] Uniformed Serv Univ Hlth Sci, Bethesda, MD USA.
RP Friedman, KL (reprint author), Vanderbilt Univ, Dept Biol Sci, 221 Kirkland Hall, Nashville, TN 37235 USA.
EM katherine.friedman@vanderbilt.edu
FU Vanderbilt University Discovery Grant; Vanderbilt University
International Scholar Program; National Science Foundation (NSF)
[MCB-0721595]
FX This work, including the efforts of Katherine L. Friedman, was funded by
Vanderbilt University Discovery Grant. This work, including the efforts
of Udochukwu C. Obodo, was funded by Vanderbilt University International
Scholar Program. This work, including the efforts of Katherine L.
Friedman, was funded by National Science Foundation (NSF) (MCB-0721595).
NR 51
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U1 0
U2 0
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0270-7306
EI 1098-5549
J9 MOL CELL BIOL
JI Mol. Cell. Biol.
PD JUN
PY 2016
VL 36
IS 12
BP 1750
EP 1763
DI 10.1128/MCB.00095-16
PG 14
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA DO7BS
UT WOS:000377937800003
PM 27044869
ER
PT J
AU Pusateri, A
AF Pusateri, A.
TI RESEARCH AND DEVELOPMENT CHALLENGES FOR NEXT GENERATION RESUSCITATION
SO SHOCK
LA English
DT Meeting Abstract
CT 39th Annual Conference of the Shock-Society on Shock
CY JUN 11-14, 2016
CL Austin, TX
SP Shock Soc
C1 [Pusateri, A.] US Army Med Res & Mat Command, Ft Detrick, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD JUN
PY 2016
VL 45
IS 6
SU 1
MA 4
BP 14
EP 14
PG 1
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA DO3OX
UT WOS:000377692000005
ER
PT J
AU Lewis, A
Wu, X
Darlington, D
Cap, A
Schwacha, M
AF Lewis, A.
Wu, X.
Darlington, D.
Cap, A.
Schwacha, M.
TI TOLL-LIKE RECEPTOR-MEDIATED REGULATION OF PLATELET FUNCTION
SO SHOCK
LA English
DT Meeting Abstract
CT 39th Annual Conference of the Shock-Society on Shock
CY JUN 11-14, 2016
CL Austin, TX
SP Shock Soc
C1 [Lewis, A.; Schwacha, M.] Univ Texas Hlth Sci Ctr San Antonio, Surg, San Antonio, TX 78229 USA.
[Wu, X.; Darlington, D.; Cap, A.; Schwacha, M.] US Army Inst Surg Res, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD JUN
PY 2016
VL 45
IS 6
SU 1
MA P26
BP 53
EP 53
PG 1
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA DO3OX
UT WOS:000377692000119
ER
PT J
AU Schaub, LJ
Cap, A
Macko, AR
Crossland, R
Glaser, J
Sheppard, FR
AF Schaub, L. J.
Cap, A.
Macko, A. R.
Crossland, R.
Glaser, J.
Sheppard, F. R.
TI THE DURATION OF HEMORRHAGIC SHOCK DIRECTLY CORRELATES WITH THE SEVERITY
OF TRAUMA INDUCED COAGULOPATHY (TIC) IN A RHESUS MACAQUE (NHP) MODEL OF
SEVERE HEMORRHAGIC SHOCK
SO SHOCK
LA English
DT Meeting Abstract
CT 39th Annual Conference of the Shock-Society on Shock
CY JUN 11-14, 2016
CL Austin, TX
SP Shock Soc
C1 [Cap, A.] US Army Inst Surg Res, Ft Sam Houston, TX USA.
[Schaub, L. J.; Macko, A. R.; Crossland, R.; Glaser, J.; Sheppard, F. R.] Naval Med Res Unit San Antonio, Ft Sam Houston, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD JUN
PY 2016
VL 45
IS 6
SU 1
MA P28
BP 53
EP 54
PG 2
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA DO3OX
UT WOS:000377692000121
ER
PT J
AU Dubick, MA
Prince, MD
Polykratis, IA
DeGuzman, R
Sondeen, JL
AF Dubick, M. A.
Prince, M. D.
Polykratis, I. A.
DeGuzman, R.
Sondeen, J. L.
TI INFLUENCE OF BLOOD PRODUCT INFUSION RATES ON SURVIVAL IN SWINE SUBJECTED
TO UNCONTROLLED HEMORRHAGE
SO SHOCK
LA English
DT Meeting Abstract
CT 39th Annual Conference of the Shock-Society on Shock
CY JUN 11-14, 2016
CL Austin, TX
SP Shock Soc
C1 [Dubick, M. A.; Prince, M. D.; Polykratis, I. A.; DeGuzman, R.; Sondeen, J. L.] US Army Inst Surg Res, DCR, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD JUN
PY 2016
VL 45
IS 6
SU 1
MA P30
BP 54
EP 54
PG 1
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA DO3OX
UT WOS:000377692000123
ER
PT J
AU Reddoch, K
Montgomery, R
Ramasubramanian, A
Cap, A
AF Reddoch, K.
Montgomery, R.
Ramasubramanian, A.
Cap, A.
TI PLATELET ADDITIVE SOLUTION (PAS) AND STORAGE AT 4 degrees C PROTECT
PLATELETS FROM INDUCTION OF APOPTOSIS COMPARED TO STORAGE AT ROOM
TEMPERATURE OR IN PLASMA: FEASIBILITY OF 15-DAY PLATELET STORAGE
SO SHOCK
LA English
DT Meeting Abstract
CT 39th Annual Conference of the Shock-Society on Shock
CY JUN 11-14, 2016
CL Austin, TX
SP Shock Soc
C1 [Ramasubramanian, A.] UTSA, San Antonio, TX USA.
[Reddoch, K.; Montgomery, R.; Cap, A.] US Army Inst Surg Res, Ft Sam Houston, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD JUN
PY 2016
VL 45
IS 6
SU 1
MA P34
BP 56
EP 56
PG 1
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA DO3OX
UT WOS:000377692000127
ER
PT J
AU Torres, I
Torres, LN
Valdez, C
Salgado, CL
Cap, A
Dubick, MA
AF Torres Filho, I.
Torres, L. N.
Valdez, C.
Salgado, C. L.
Cap, A.
Dubick, M. A.
TI COLD-STORED PLATELETS STUDIED IN NORMOVOLEMIC AND HEMORRHAGED RATS USING
CONFOCAL INTRAVITAL VIDEOMICROSCOPY
SO SHOCK
LA English
DT Meeting Abstract
CT 39th Annual Conference of the Shock-Society on Shock
CY JUN 11-14, 2016
CL Austin, TX
SP Shock Soc
C1 [Torres Filho, I.; Torres, L. N.; Valdez, C.; Salgado, C. L.; Cap, A.; Dubick, M. A.] US Army, Inst Surg Res, Damage Control Resuscitat, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD JUN
PY 2016
VL 45
IS 6
SU 1
MA P42
BP 59
EP 59
PG 1
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA DO3OX
UT WOS:000377692000135
ER
PT J
AU Torres, LN
Salgado, CL
Xia, H
Dubick, MA
Torres, I
AF Torres, L. N.
Salgado, C. L.
Xia, H.
Dubick, M. A.
Torres Filho, I.
TI RESUSCITATION WITH LOW VOLUME ADJUNCTS COMBINED WITH LACTATED RINGER'S
PROMOTES ENDOTHELIAL GLYCOCALYX (EG) RECOVERY IN VIVO DURING HEMORRHAGIC
SHOCK IN RATS
SO SHOCK
LA English
DT Meeting Abstract
CT 39th Annual Conference of the Shock-Society on Shock
CY JUN 11-14, 2016
CL Austin, TX
SP Shock Soc
C1 [Torres, L. N.; Salgado, C. L.; Xia, H.; Dubick, M. A.; Torres Filho, I.] US Army, Inst Surg Res, Damage Control Resuscitat, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD JUN
PY 2016
VL 45
IS 6
SU 1
MA P46
BP 60
EP 61
PG 2
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA DO3OX
UT WOS:000377692000139
ER
PT J
AU Burmeister, DM
Baker, B
McIntyre, M
Natesan, S
Christy, R
AF Burmeister, D. M.
Baker, B.
McIntyre, M.
Natesan, S.
Christy, R.
TI CHARACTERIZATION OF SYSTEMIC INFLAMMATION AND THE EFFECTS ON DISTANT
ORGANS AFTER EXTENSIVE CONTACT BURNS IN SWINE
SO SHOCK
LA English
DT Meeting Abstract
CT 39th Annual Conference of the Shock-Society on Shock
CY JUN 11-14, 2016
CL Austin, TX
SP Shock Soc
C1 [Burmeister, D. M.; Baker, B.; McIntyre, M.; Natesan, S.; Christy, R.] US Army Inst Surg Res, Damage Control Resuscitat, Ft Sam Houston, TX USA.
NR 0
TC 0
Z9 0
U1 2
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD JUN
PY 2016
VL 45
IS 6
SU 1
MA P94
BP 80
EP 81
PG 2
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA DO3OX
UT WOS:000377692000187
ER
PT J
AU Macko, AR
Cap, A
Schaub, LJ
Crossland, R
Hemond, P
Glaser, J
Sheppard, FR
AF Macko, A. R.
Cap, A.
Schaub, L. J.
Crossland, R.
Hemond, P.
Glaser, J.
Sheppard, F. R.
TI EFFECTS OF POLYTRAUMATIC INJURY WITH HEMORRHAGIC SHOCK ON COAGULATION
SYSTEM FUNCTION IN A NON-HUMAN PRIMATE (RHESUS MACAQUE) MODEL
SO SHOCK
LA English
DT Meeting Abstract
CT 39th Annual Conference of the Shock-Society on Shock
CY JUN 11-14, 2016
CL Austin, TX
SP Shock Soc
C1 [Macko, A. R.; Schaub, L. J.; Crossland, R.; Hemond, P.; Glaser, J.; Sheppard, F. R.] Naval Med Res Unit San Antonio, Ft Sam Houston, TX USA.
[Cap, A.] US Army Inst Surg Res, Ft Sam Houston, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD JUN
PY 2016
VL 45
IS 6
SU 1
MA P114
BP 89
EP 89
PG 1
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA DO3OX
UT WOS:000377692000207
ER
PT J
AU Cannon, JW
Hurst, K
Brostoff, N
Namas, R
Cotton, B
Schreiber, M
Chung, K
Chang, S
Cap, A
Vodovotz, Y
AF Cannon, J. W.
Hurst, K.
Brostoff, N.
Namas, R.
Cotton, B.
Schreiber, M.
Chung, K.
Chang, S.
Cap, A.
Vodovotz, Y.
TI TRAUMA IN SILICO: A COMPUTATIONAL MODEL OF ACUTE HEMORRHAGE,
COAGULOPATHY, AND RESUSCITATION
SO SHOCK
LA English
DT Meeting Abstract
CT 39th Annual Conference of the Shock-Society on Shock
CY JUN 11-14, 2016
CL Austin, TX
SP Shock Soc
C1 [Cannon, J. W.] Univ Penn, Surg, Philadelphia, PA 19104 USA.
[Hurst, K.; Brostoff, N.; Chang, S.] Immunetrics, Pittsburgh, PA USA.
[Namas, R.; Vodovotz, Y.] Univ Pittsburgh, Pittsburgh, PA USA.
[Chung, K.; Cap, A.] US Army Inst Surg Res, JBSA Ft Sam Houston, Ft Sam Houston, TX USA.
[Cotton, B.] Univ Texas Hlth Sci Ctr Houston, Houston, TX 77030 USA.
[Schreiber, M.] Oregon Hlth & Sci Univ, Portland, OR 97201 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD JUN
PY 2016
VL 45
IS 6
SU 1
MA P116
BP 90
EP 90
PG 1
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA DO3OX
UT WOS:000377692000209
ER
PT J
AU Martini, WZ
DeGuzman, R
Rodriguez, C
Bice, L
Polykratis, IA
Cap, A
Dubick, MA
AF Martini, W. Z.
DeGuzman, R.
Rodriguez, C.
Bice, L.
Polykratis, I. A.
Cap, A.
Dubick, M. A.
TI FIBRINOGEN CONCENTRATE STABILITY UNDER DIFFERENT TEMPERATURES AND
DURATIONS
SO SHOCK
LA English
DT Meeting Abstract
CT 39th Annual Conference of the Shock-Society on Shock
CY JUN 11-14, 2016
CL Austin, TX
SP Shock Soc
C1 [Martini, W. Z.; DeGuzman, R.; Rodriguez, C.; Bice, L.; Polykratis, I. A.; Cap, A.; Dubick, M. A.] US Army Inst Surg Res, Ft Sam Houston, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD JUN
PY 2016
VL 45
IS 6
SU 1
MA P121
BP 92
EP 92
PG 1
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA DO3OX
UT WOS:000377692000214
ER
PT J
AU Wu, X
Benov, A
Liu, B
Keesee, JD
Schwacha, MG
Cap, A
Darlington, DN
AF Wu, X.
Benov, A.
Liu, B.
Keesee, J. D.
Schwacha, M. G.
Cap, A.
Darlington, D. N.
TI RESUSCITATION WITH TRANEXAMIC ACID AND FRESH WHOLE BLOOD REDUCES THE
SEVERITY OF ACUTE LUNG INJURY AFTER POLYTRAUMA AND HEMORRHAGE IN RAT
SO SHOCK
LA English
DT Meeting Abstract
CT 39th Annual Conference of the Shock-Society on Shock
CY JUN 11-14, 2016
CL Austin, TX
SP Shock Soc
C1 [Wu, X.; Benov, A.; Liu, B.; Keesee, J. D.; Schwacha, M. G.; Cap, A.; Darlington, D. N.] US Army Inst Surg Res, San Antonio, TX USA.
[Wu, X.; Schwacha, M. G.; Cap, A.; Darlington, D. N.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.
[Benov, A.] Israel Def Forces Med Corps, Tel Hashomer, Israel.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD JUN
PY 2016
VL 45
IS 6
SU 1
MA P138
BP 99
EP 99
PG 1
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA DO3OX
UT WOS:000377692000231
ER
PT J
AU Li, Y
Sheppard, FR
Liu, B
Dubick, MA
Cancio, LC
Dallelucca, J
AF Li, Y.
Sheppard, F. R.
Liu, B.
Dubick, M. A.
Cancio, L. C.
Dallelucca, J.
TI GAMMA DELTA T LYMPHOCYTE INFILTRATION CONTRIBUTES TO HEMORRHAGIC
SHOCK-INDUCED PULMONARY INJURY IN RATS
SO SHOCK
LA English
DT Meeting Abstract
CT 39th Annual Conference of the Shock-Society on Shock
CY JUN 11-14, 2016
CL Austin, TX
SP Shock Soc
C1 [Li, Y.; Liu, B.; Dubick, M. A.; Cancio, L. C.] US Army Inst Surg Res, Task Area Multiple Organ Support Technol, Jbsa Ft Sam Houston, TX USA.
[Sheppard, F. R.] Naval Med Res Unit San Antonio, Jbsa Ft Sam Houston, TX USA.
[Dallelucca, J.] Dept Def Threat Reduct Agcy, Ft Belvoir, VA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD JUN
PY 2016
VL 45
IS 6
SU 1
MA P194
BP 119
EP 119
PG 1
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA DO3OX
UT WOS:000377692000286
ER
PT J
AU Walters, TJ
AF Walters, T. J.
TI HEMORRHAGIC SHOCK AND RESUSCITATION EXACERBATE TOURNIQUET INDUCED
ISCHEMIA REPERFUSION MUSCLE FIBER DAMAGE
SO SHOCK
LA English
DT Meeting Abstract
CT 39th Annual Conference of the Shock-Society on Shock
CY JUN 11-14, 2016
CL Austin, TX
SP Shock Soc
C1 [Walters, T. J.] US Army Inst Surg Res, Extrem Trauma & Regenerat Med, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD JUN
PY 2016
VL 45
IS 6
SU 1
MA P198
BP 120
EP 121
PG 2
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA DO3OX
UT WOS:000377692000290
ER
PT J
AU Antebi, B
McDaniel, JS
Cancio, LC
Batchinsky, AI
AF Antebi, B.
McDaniel, J. S.
Cancio, L. C.
Batchinsky, A. I.
TI QUANTITATIVE ASSESSMENT OF OPTIMAL BONE MARROW SITE FOR THE ISOLATION OF
MESENCHYMAL STEM CELLS
SO SHOCK
LA English
DT Meeting Abstract
CT 39th Annual Conference of the Shock-Society on Shock
CY JUN 11-14, 2016
CL Austin, TX
SP Shock Soc
C1 [Antebi, B.; McDaniel, J. S.; Cancio, L. C.; Batchinsky, A. I.] US Army Inst Surg Res, MOST, Jbsa Ft Sam Houston, TX USA.
[Antebi, B.; Batchinsky, A. I.] Geneva Fdn, Tacoma, WA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD JUN
PY 2016
VL 45
IS 6
SU 1
MA P237
BP 134
EP 134
PG 1
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA DO3OX
UT WOS:000377692000329
ER
PT J
AU Beely, BM
Antebi, B
Walker, KP
Cancio, LC
Batchinsky, AI
AF Beely, B. M.
Antebi, B.
Walker, K. P.
Cancio, L. C.
Batchinsky, A. I.
TI FEASIBILITY OF DELIVERING MESENCHYMAL STEM CELLS VIA AEROSOLIZATION: AN
EX VIVO STUDY
SO SHOCK
LA English
DT Meeting Abstract
CT 39th Annual Conference of the Shock-Society on Shock
CY JUN 11-14, 2016
CL Austin, TX
SP Shock Soc
C1 [Beely, B. M.; Antebi, B.; Walker, K. P.; Cancio, L. C.; Batchinsky, A. I.] US Army Inst Surg Res, Multiorgan Support Technol, San Antonio, TX USA.
[Beely, B. M.; Antebi, B.; Batchinsky, A. I.] Geneva Fdn, Tacoma, WA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD JUN
PY 2016
VL 45
IS 6
SU 1
MA P238
BP 134
EP 135
PG 2
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA DO3OX
UT WOS:000377692000330
ER
PT J
AU Ketter, P
Ainsworth, S
Arulanandam, B
Cap, A
AF Ketter, P.
Ainsworth, S.
Arulanandam, B.
Cap, A.
TI THIOREDOXIN: A MODULATOR OF MULTI-DRUG RESISTANT ACINETOBACTER BAUMANNII
SEPSIS
SO SHOCK
LA English
DT Meeting Abstract
CT 39th Annual Conference of the Shock-Society on Shock
CY JUN 11-14, 2016
CL Austin, TX
SP Shock Soc
C1 [Ketter, P.; Cap, A.] US Army Inst Surg Res, Coagulat & Blood Res, Jbsa Ft Sam Houston, TX USA.
[Ainsworth, S.; Arulanandam, B.] Univ Texas San Antonio, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD JUN
PY 2016
VL 45
IS 6
SU 1
MA P245
BP 137
EP 138
PG 2
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA DO3OX
UT WOS:000377692000337
ER
PT J
AU Torres, IP
Torres, LN
Salgado, C
Dubick, MA
AF Torres Filho, Ivo P.
Torres, Luciana N.
Salgado, Christi
Dubick, Michael A.
TI Plasma syndecan-1 and heparan sulfate correlate with microvascular
glycocalyx degradation in hemorrhaged rats after different resuscitation
fluids
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE hemorrhage; resuscitation; microcirculation; glycocalyx; syndecan;
muscle; shock
ID ISCHEMIA-REPERFUSION INJURY; ENDOTHELIAL SURFACE-LAYER; BLOOD-FLOW;
IN-VIVO; VENULAR GLYCOCALYX; THERAPEUTIC TARGET; TRAUMA PATIENTS; SHOCK;
INFLAMMATION; BARRIER
AB The endothelial glycocalyx plays an essential role in many physiological functions and is damaged after hemorrhage. Fluid resuscitation may further change the glycocalyx after an initial hemorrhage-induced degradation. Plasma levels of syndecan-1 and heparan sulfate have been used as indirect markers for glycocalyx degradation, but the extent to which these measures are representative of the events in the microcirculation is unknown. Using hemorrhage and a wide range of resuscitation fluids, we studied quantitatively the relationship between plasma biomarkers and changes in microvascular parameters, including glycocalyx thickness. Rats were bled 40% of total blood volume and resuscitated with seven different fluids (fresh whole blood, blood products, and crystalloids). Intravital microscopy was used to estimate glycocalyx thickness in >270 postcapillary venules from 58 cremaster preparations in 9 animal groups; other microvascular parameters were measured using noninvasive techniques. Systemic physiological parameters and blood chemistry were simultaneously collected. Changes in glycocalyx thickness were negatively correlated with changes in plasma levels of syndecan-1 (r = -0.937) and heparan sulfate (r = -0.864). Changes in microvascular permeability were positively correlated with changes in both plasma biomarkers (r = 0.8, P < 0.05). Syndecan-1 and heparan sulfate were also positively correlated (r = 0.7, P < 0.05). Except for diameter and permeability, changes in local microcirculatory parameters (red blood cell velocity, blood flow, and wall shear rate) did not correlate with plasma biomarkers or glycocalyx thickness changes. This work provides a quantitative framework supporting plasma syndecan-1 and heparan sulfate as valuable clinical biomarkers of glycocalyx shedding that may be useful in guiding resuscitation strategies following hemorrhage.
C1 [Torres Filho, Ivo P.; Torres, Luciana N.; Salgado, Christi; Dubick, Michael A.] US Army, Inst Surg Res, Damage Control Resuscitat, Ft Sam Houston, TX 78234 USA.
RP Torres, IP (reprint author), US Army, Inst Surg Res, 3650 Chambers Pass,BHT 2,Rm 282-1, Ft Sam Houston, TX 78234 USA.
EM ivo.p.torresfilho.civ@mail.mil
FU US Army Medical Research Materiel Command
FX This study was supported by the US Army Medical Research Materiel
Command. It was performed in part while I. P. Torres Filho and L. N.
Torres were employed by Premier Consulting & Management Services and
Cherokee Nation Businesses, respectively.
NR 67
TC 0
Z9 0
U1 3
U2 5
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD JUN 1
PY 2016
VL 310
IS 11
BP H1468
EP H1478
DI 10.1152/ajpheart.00006.2016
PG 11
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
Disease
SC Cardiovascular System & Cardiology; Physiology
GA DN9XQ
UT WOS:000377434400010
PM 27037369
ER
PT J
AU Koju, RK
Darling, KA
Kecskes, LJ
Mishin, Y
AF Koju, R. K.
Darling, K. A.
Kecskes, L. J.
Mishin, Y.
TI Zener Pinning of Grain Boundaries and Structural Stability of Immiscible
Alloys
SO JOM
LA English
DT Article
ID CU-TA ALLOYS; NANOCRYSTALLINE ALLOYS; MOLECULAR-DYNAMICS; STABILIZATION;
GROWTH; DRAG; MOTION; COPPER; SIMULATIONS; MIGRATION
AB Immiscible Cu-Ta alloys produced by mechanical alloying are currently the subject of intensive research due to their mechanical strength combined with extraordinary structural stability at high temperatures. Previous experimental and simulation studies suggested that grain boundaries (GBs) in Cu-Ta alloys are stabilized by Ta nano-clusters coherent with the Cu matrix. To better understand the stabilization effect of Ta, we performed atomistic computer simulations of GB-cluster interactions in Cu-Ta alloys with various compositions and GB velocities. The study focuses on a single plane GB driven by an applied shear stress due to the shear-coupling effect. The results of the simulations are in close quantitative agreement with the Zener model of GB pinning. This agreement and the large magnitude of the unpinning stress confirm that the structural stability of these alloys is due to the drastically decreased GB mobility rather than a reduction in GB energy. For comparison, we simulated GB motion in a random solid solution. While the latter also reduces the GB mobility, the effect is not as strong as in the presence of Ta clusters. GB motion in the random solution itself induces precipitation of Ta clusters due to short-circuit diffusion of Ta in GBs, suggesting a possible mechanism of cluster formation inside the grains.
C1 [Koju, R. K.; Mishin, Y.] George Mason Univ, Dept Phys & Astron, MSN 3F3, Fairfax, VA 22030 USA.
[Darling, K. A.; Kecskes, L. J.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Mishin, Y (reprint author), George Mason Univ, Dept Phys & Astron, MSN 3F3, Fairfax, VA 22030 USA.
EM ymishin@gmu.edu
RI Mishin, Yuri/P-2020-2015
FU U.S. Army Research Office [W911NF-15-1-0077]
FX R.KK. and Y. M. were supported by the U.S. Army Research Office under a
Contract Number W911NF-15-1-0077.
NR 39
TC 1
Z9 1
U1 6
U2 15
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1047-4838
EI 1543-1851
J9 JOM-US
JI JOM
PD JUN
PY 2016
VL 68
IS 6
BP 1596
EP 1604
DI 10.1007/s11837-016-1899-9
PG 9
WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical
Engineering; Mineralogy; Mining & Mineral Processing
SC Materials Science; Metallurgy & Metallurgical Engineering; Mineralogy;
Mining & Mineral Processing
GA DN9XI
UT WOS:000377433600014
ER
PT J
AU Coleman, SP
Hernandez-Rivera, E
Behler, KD
Synowczynski-Dunn, J
Tschopp, MA
AF Coleman, Shawn P.
Hernandez-Rivera, Efrain
Behler, Kristopher D.
Synowczynski-Dunn, Jennifer
Tschopp, Mark A.
TI Challenges of Engineering Grain Boundaries in Boron-Based Armor Ceramics
SO JOM
LA English
DT Article
ID MOLECULAR-DYNAMICS SIMULATION; SILICON-NITRIDE CERAMICS; IMPROVED
FRACTURE-TOUGHNESS; INTERGRANULAR GLASSY FILMS; REACTIVE FORCE-FIELD;
MECHANICAL-PROPERTIES; CARBIDE B4C; MICROSTRUCTURAL DESIGN; ELASTIC
PROPERTIES; NANOTUBES
AB Boron-based ceramics are appealing for lightweight applications in both vehicle and personnel protection, stemming from their combination of high hardness, high elastic modulus, and low density as compared to other ceramics and metal alloys. However, the performance of these ceramics and ceramic composites is lacking because of their inherent low fracture toughness and reduced strength under high-velocity threats. The objective of the present article is to briefly discuss both the challenges and the state of the art in experimental and computational approaches for engineering grain boundaries in boron-based armor ceramics, focusing mainly on boron carbide (B4C) and boron suboxide (B6O). The experimental challenges involve processing these ceramics at full density while trying to promote microstructure features such as intergranular films to improve toughness during shock. Many of the computational challenges for boron-based ceramics stem from their complex crystal structure which has hitherto complicated the exploration of grain boundaries and interfaces. However, bridging the gaps between experimental and computational studies at multiple scales to engineer grain boundaries in these boron-based ceramics may hold the key to maturing these material systems for lightweight defense applications.
C1 [Coleman, Shawn P.; Hernandez-Rivera, Efrain; Behler, Kristopher D.; Synowczynski-Dunn, Jennifer; Tschopp, Mark A.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Behler, Kristopher D.] TKC Global, Herndon, VA 20171 USA.
RP Coleman, SP (reprint author), US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM shawn.p.coleman8.ctr@mail.mil; mark.a.tsch-opp.civ@mail.mil
RI Tschopp, Mark/B-1594-2008
OI Tschopp, Mark/0000-0001-8471-5035
NR 99
TC 0
Z9 0
U1 9
U2 12
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1047-4838
EI 1543-1851
J9 JOM-US
JI JOM
PD JUN
PY 2016
VL 68
IS 6
BP 1605
EP 1615
DI 10.1007/s11837-016-1856-7
PG 11
WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical
Engineering; Mineralogy; Mining & Mineral Processing
SC Materials Science; Metallurgy & Metallurgical Engineering; Mineralogy;
Mining & Mineral Processing
GA DN9XI
UT WOS:000377433600015
ER
PT J
AU Anthony, SM
Rivas, SC
Colpitts, SL
Howard, ME
Stonier, SW
Schluns, KS
AF Anthony, Scott M.
Rivas, Sarai C.
Colpitts, Sara L.
Howard, Megan E.
Stonier, Spencer W.
Schluns, Kimberly S.
TI Inflammatory Signals Regulate IL-15 in Response to Lymphodepletion
SO JOURNAL OF IMMUNOLOGY
LA English
DT Article
ID CD8(+) T-CELLS; IN-VIVO; TRANS-PRESENTATION; DENDRITIC CELLS; MICROBIAL
TRANSLOCATION; SOLUBLE IL-15R-ALPHA; METASTATIC MELANOMA; IMMUNOGENIC
TUMORS; NK CELLS; EXPRESSION
AB Induction of lymphopenia has been exploited therapeutically to improve immune responses to cancer therapies and vaccinations. Whereas IL-15 has well-established roles in stimulating lymphocyte responses after lymphodepletion, the mechanisms regulating these IL-15 responses are unclear. We report that cell surface IL-15 expression is upregulated during lymphopenia induced by total body irradiation (TBI), cyclophosphamide, or Thy1 Ab-mediated T cell depletion, as well as in RAG(-/-) mice; interestingly, the cellular profile of surface IL-15 expression is distinct in each model. In contrast, soluble IL-15 (sIL-15) complexes are upregulated only after TBI or alpha Thy1 Ab. Analysis of cell-specific IL-15R alpha conditional knockout mice revealed that macrophages and dendritic cells are important sources of sIL-15 complexes after TBI but provide minimal contribution in response to Thy1 Ab treatment. Unlike with TBI, induction of sIL-15 complexes by aThy1 Ab is sustained and only partially dependent on type I IFNs. The stimulator of IFN genes pathway was discovered to be a potent inducer of sIL-15 complexes and was required for optimal production of sIL-15 complexes in response to Ab-mediated T cell depletion and TBI, suggesting products of cell death drive production of sIL-15 complexes after lymphodepletion. Lastly, we provide evidence that IL-15 induced by inflammatory signals in response to lymphodepletion drives lymphocyte responses, as memory CD8 T cells proliferated in an IL-15-dependent manner. Overall, these studies demonstrate that the form in which IL-15 is expressed, its kinetics and cellular sources, and the inflammatory signals involved are differentially dictated by the manner in which lymphopenia is induced.
C1 [Anthony, Scott M.; Stonier, Spencer W.; Schluns, Kimberly S.] Univ Texas Houston, Grad Sch Biomed Sci, Grad Program Immunol, Houston, TX 77030 USA.
[Anthony, Scott M.; Rivas, Sarai C.; Howard, Megan E.; Stonier, Spencer W.; Schluns, Kimberly S.] Univ Texas MD Anderson Canc Ctr, Dept Immunol, MC 902,POB 301429, Houston, TX 77030 USA.
[Colpitts, Sara L.] Univ Connecticut, Hlth Sci Ctr, Dept Immunol, Farmington, CT 06030 USA.
[Anthony, Scott M.] Univ Iowa, Dept Microbiol, Iowa City, IA 52242 USA.
[Colpitts, Sara L.] Dartmouth Coll, Geisel Sch Med, Dept Microbiol & Immunol, Hanover, NH 03755 USA.
[Stonier, Spencer W.] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
RP Schluns, KS (reprint author), Univ Texas MD Anderson Canc Ctr, Dept Immunol, MC 902,POB 301429, Houston, TX 77030 USA.
EM kschluns@mdanderson.org
FU National Institutes of Health Predoctoral Training Grant [CA009598];
American Cancer Society [PF-11-152-01-LIB]; Center for Inflammation and
Cancer at the MD Anderson Cancer Center; Center for Inflammation and
Cancer at the MD Anderson Bridge funding
FX This work was supported by National Institutes of Health Predoctoral
Training Grant CA009598 (to S.M.A. and S.W.S.), Postdoctoral Fellowship
PF-11-152-01-LIB from the American Cancer Society (to S.L.C.), and a
seed fund from the Center for Inflammation and Cancer at the MD Anderson
Cancer Center and MD Anderson Bridge funding (to K.S.S.).
NR 49
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PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD JUN 1
PY 2016
VL 196
IS 11
BP 4544
EP 4552
DI 10.4049/jimmunol.1600219
PG 9
WC Immunology
SC Immunology
GA DO3IU
UT WOS:000377676000014
PM 27183627
ER
PT J
AU Payne, RO
Milne, KH
Elias, SC
Edwards, NJ
Douglas, AD
Brown, RE
Silk, SE
Biswas, S
Miura, K
Roberts, R
Rampling, TW
Venkatraman, N
Hodgson, SH
Labbe, GM
Halstead, FD
Poulton, ID
Nugent, FL
de Graaf, H
Sukhtankar, P
Williams, NC
Ockenhouse, CF
Kathcart, AK
Qabar, AN
Waters, NC
Soisson, LA
Birkett, AJ
Cooke, GS
Faust, SN
Woods, C
Ivinson, K
McCarthy, JS
Diggs, CL
Vekemans, J
Long, CA
Hill, AVS
Lawrie, AM
Dutta, S
Draper, SJ
AF Payne, Ruth O.
Milne, Kathryn H.
Elias, Sean C.
Edwards, Nick J.
Douglas, Alexander D.
Brown, Rebecca E.
Silk, Sarah E.
Biswas, Sumi
Miura, Kazutoyo
Roberts, Rachel
Rampling, Thomas W.
Venkatraman, Navin
Hodgson, Susanne H.
Labbe, Genevieve M.
Halstead, Fenella D.
Poulton, Ian D.
Nugent, Fay L.
de Graaf, Hans
Sukhtankar, Priya
Williams, Nicola C.
Ockenhouse, Christian F.
Kathcart, April K.
Qabar, Aziz N.
Waters, Norman C.
Soisson, Lorraine A.
Birkett, Ashley J.
Cooke, Graham S.
Faust, Saul N.
Woods, Colleen
Ivinson, Karen
McCarthy, James S.
Diggs, Carter L.
Vekemans, Johan
Long, Carole A.
Hill, Adrian V. S.
Lawrie, Alison M.
Dutta, Sheetij
Draper, Simon J.
TI Demonstration of the Blood-Stage Plasmodium falciparum Controlled Human
Malaria Infection Model to Assess Efficacy of the P. falciparum Apical
Membrane Antigen 1 Vaccine, FMP2.1/AS01
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
DE malaria; AMA1; vaccine; blood stage; CHMI
ID PARASITE MULTIPLICATION RATES; RANDOMIZED CONTROLLED-TRIAL;
CLINICAL-TRIAL; IMMUNOGENICITY; ANTIBODY; SAFETY; SPOROZOITES;
VOLUNTEERS; CHALLENGE; PROTEIN
AB Background. Models of controlled human malaria infection (CHMI) initiated by mosquito bite have been widely used to assess efficacy of preerythrocytic vaccine candidates in small proof-of-concept phase 2a clinical trials. Efficacy testing of blood-stage malaria parasite vaccines, however, has generally relied on larger-scale phase 2b field trials in malaria-endemic populations. We report the use of a blood-stage P. falciparum CHMI model to assess blood-stage vaccine candidates, using their impact on the parasite multiplication rate (PMR) as the primary efficacy end point.
Methods. Fifteen healthy United Kingdom adult volunteers were vaccinated with FMP2.1, a protein vaccine that is based on the 3D7 clone sequence of apical membrane antigen 1 (AMA1) and formulated in Adjuvant System 01 (AS01). Twelve vaccinees and 15 infectivity controls subsequently underwent blood-stage CHMI. Parasitemia was monitored by quantitative real-time polymerase chain reaction (PCR) analysis, and PMR was modeled from these data.
Results. FMP2.1/AS01 elicited anti-AMA1 T-cell and serum antibody responses. Analysis of purified immunoglobulin G showed functional growth inhibitory activity against P. falciparum in vitro. There were no vaccine-or CHMI-related safety concerns. All volunteers developed blood-stage parasitemia, with no impact of the vaccine on PMR.
Conclusions. FMP2.1/AS01 demonstrated no efficacy after blood-stage CHMI. However, the model induced highly reproducible infection in all volunteers and will accelerate proof-of-concept testing of future blood-stage vaccine candidates.
C1 [Payne, Ruth O.; Milne, Kathryn H.; Elias, Sean C.; Edwards, Nick J.; Douglas, Alexander D.; Brown, Rebecca E.; Silk, Sarah E.; Biswas, Sumi; Rampling, Thomas W.; Venkatraman, Navin; Hodgson, Susanne H.; Labbe, Genevieve M.; Halstead, Fenella D.; Nugent, Fay L.; Hill, Adrian V. S.; Draper, Simon J.] Univ Oxford, Jenner Inst Labs, Oxford OX1 2JD, England.
[Payne, Ruth O.; Roberts, Rachel; Rampling, Thomas W.; Venkatraman, Navin; Hodgson, Susanne H.; Poulton, Ian D.; Lawrie, Alison M.] Univ Oxford, Ctr Clin Vaccinol & Trop Med, Oxford OX1 2JD, England.
[Williams, Nicola C.] Univ Oxford, Ctr Stat Med, Oxford OX1 2JD, England.
[Williams, Nicola C.] Univ Oxford, Botnar Res Ctr, Oxford OX1 2JD, England.
[de Graaf, Hans; Sukhtankar, Priya; Faust, Saul N.] Univ Hosp Southampton Natl Hlth Serv NHS Fdn Trus, Natl Inst Hlth Res NIHR Wellcome Trust Clin Res F, Southampton, Hants, England.
[de Graaf, Hans; Sukhtankar, Priya; Faust, Saul N.] Univ Southampton, Fac Med, Southampton SO9 5NH, Hants, England.
[Cooke, Graham S.] Imperial Coll Healthcare NHS Trust, NIHR Wellcome Trust Clin Res Facil, London, England.
[Miura, Kazutoyo; Long, Carole A.] NIAID, Lab Malaria & Vector Res, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
[Ockenhouse, Christian F.; Kathcart, April K.; Qabar, Aziz N.; Waters, Norman C.; Dutta, Sheetij] Walter Reed Army Inst Res, Mil Malaria Res Program, Silver Spring, MD USA.
[Ockenhouse, Christian F.; Birkett, Ashley J.; Woods, Colleen; Ivinson, Karen] PATH Malaria Vaccine Initiat, Washington, DC USA.
[Soisson, Lorraine A.; Diggs, Carter L.] US Agcy Int Dev, Washington, DC 20523 USA.
[McCarthy, James S.] QIMR Berghofer Med Res Inst, Herston, Qld, Australia.
[Vekemans, Johan] GlaxoSmithKline Vaccines, Rixensart, Belgium.
RP Payne, RO (reprint author), Churchill Hosp, CCVTM, Old Rd, Oxford OX3 7LE, England.
EM ruth.payne@ndm.ox.ac.uk
FU PATH Malaria Vaccine Initiative (MVI), through the Infectious Disease
Division, Bureau for Global Health, US Agency for International
Development [GHS-A-00-04-00016-00]; National Institute of Allergy and
Infectious Diseases, National Institutes of Health; United Kingdom
National Institute of Health Research (NIHR) infrastructure, through the
NIHR Oxford Biomedical Research Centre; United Kingdom National
Institute of Health Research (NIHR) infrastructure, through Southampton
NIHR Wellcome Trust Clinical Research Facility; United Kingdom National
Institute of Health Research (NIHR) infrastructure, through Imperial
College NIHR Wellcome Trust Clinical Research Facility; Wellcome Trust
[089455/2/09/Z, 097940/Z/11/Z]; St Catherine's College, Oxford
University; Nuffield Department of Medicine; Jenner Institute; Lister
Institute; United Kingdom Medical Research Council (MRC); Department for
International Development (DFID); EDCTP2 program; European Union (MRC)
[G1000527]
FX This work was supported by the PATH Malaria Vaccine Initiative (MVI),
through the Infectious Disease Division, Bureau for Global Health, US
Agency for International Development (under cooperative agreement
GHS-A-00-04-00016-00); by the Intramural Program of the National
Institute of Allergy and Infectious Diseases, National Institutes of
Health; by the United Kingdom National Institute of Health Research
(NIHR) infrastructure, through the NIHR Oxford Biomedical Research
Centre, the Southampton NIHR Wellcome Trust Clinical Research Facility,
and the Imperial College NIHR Wellcome Trust Clinical Research Facility;
by the Wellcome Trust (research training fellowships 089455/2/09/Z [to
A. D. D.] and 097940/Z/11/Z [to S. H. H.]); by St Catherine's College,
Oxford University (junior research fellowship to S. B.) and Nuffield
Department of Medicine leadership fellowship (to S. B.); by the Jenner
Institute (Jenner Investigator appointments to A. V. S. H. and S. J.
D.); by the Lister Institute (research prize fellowship to S. J. D.);
and, jointly, by the United Kingdom Medical Research Council (MRC) and
Department for International Development (DFID), under the MRC/DFID
Concordat agreement, and by the EDCTP2 program, supported by the
European Union (MRC career development fellowship G1000527 to S. J. D.).
NR 44
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PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1899
EI 1537-6613
J9 J INFECT DIS
JI J. Infect. Dis.
PD JUN 1
PY 2016
VL 213
IS 11
BP 1743
EP 1751
DI 10.1093/infdis/jiw039
PG 9
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA DO0BC
UT WOS:000377443400011
PM 26908756
ER
PT J
AU Troha, T
Rigler, M
Alden, D
Bryan, I
Guo, W
Kirste, R
Mita, S
Gerhold, MD
Collazo, R
Sitar, Z
Zgonik, M
AF Troha, T.
Rigler, M.
Alden, D.
Bryan, I.
Guo, W.
Kirste, R.
Mita, S.
Gerhold, M. D.
Collazo, R.
Sitar, Z.
Zgonik, M.
TI UV second harmonic generation in AlN waveguides with modal phase
matching
SO OPTICAL MATERIALS EXPRESS
LA English
DT Article
ID LASER-DIODE; THIN-FILMS; LIGHT; BLUE; AIN; GAN
AB AlN waveguides on sapphire substrates were fabricated from AlN films grown by metalorganic chemical vapor deposition. By tuning the wavelength of the pump light we demonstrated a second harmonic generation in the UV at 306, 331, and 356 nm using the d(33) coefficient and modal dispersion phase matching (MDPM). A theoretical model for MDPM with two-and three-mode interaction in planar waveguides was used to explain the results. Its essential component describes the interaction of two, possibly different, waveguide modes at the fundamental frequency that excite the third mode at doubled frequency. The experimental results were found to agree well with the theoretical model. This work confirmed the application potential of high-quality AlN films as waveguides for nonlinear processes. (C) 2016 Optical Society of America
C1 [Troha, T.; Rigler, M.; Zgonik, M.] Univ Ljubljana, Fac Math & Phys, Jadranska 19, Ljubljana 1000, Slovenia.
[Alden, D.; Bryan, I.; Guo, W.; Sitar, Z.] N Carolina State Univ, Dept Mat Sci & Engn, 1001 Capability Dr Raleigh, Raleigh, NC 27606 USA.
[Kirste, R.; Mita, S.; Collazo, R.] Adroit Mat, 2054 Kildaire Farm Rd,Suite 205, Cary, NC 27518 USA.
[Gerhold, M. D.] Engn Sci Directorate, Army Res Off, POB 12211, Res Triangle Pk, NC 27703 USA.
[Zgonik, M.] Jozef Stefan Inst, Jamova 39, Ljubljana 1000, Slovenia.
RP Troha, T (reprint author), Univ Ljubljana, Fac Math & Phys, Jadranska 19, Ljubljana 1000, Slovenia.
EM tinkara.troha@fmf.uni-lj.si
FU NSF [DMR-1108071, DMR-1312582, ECCS-1508854, DMR-1508191]; ARO
[W911NF-15-2-0068, W911NF-14-C-0008]; ARRS [N1-0021]
FX Partial financial support from NSF (DMR-1108071, DMR-1312582,
ECCS-1508854, DMR-1508191), ARO (W911NF-15-2-0068, W911NF-14-C-0008),
and ARRS (N1-0021) is greatly appreciated.
NR 22
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PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 2159-3930
J9 OPT MATER EXPRESS
JI Opt. Mater. Express
PD JUN 1
PY 2016
VL 6
IS 6
BP 2014
EP 2023
PG 10
WC Materials Science, Multidisciplinary; Optics
SC Materials Science; Optics
GA DO0ZG
UT WOS:000377507100024
ER
PT J
AU Bastian, ND
Griffin, PM
Spero, E
Fulton, LV
AF Bastian, Nathaniel D.
Griffin, Paul M.
Spero, Eric
Fulton, Lawrence V.
TI Multi-criteria logistics modeling for military humanitarian assistance
and disaster relief aerial delivery operations
SO OPTIMIZATION LETTERS
LA English
DT Article
DE Multiple criteria decision analysis; Stochastic optimization; Facility
location; Humanitarian logistics; Supply chain engineering; Aerial
delivery operations
ID OPTIMIZATION
AB Given that it is not always feasible to reach an affected area via land or sea within the first week following a natural disaster, aerial delivery provides the primary means to rapidly supply the affected population. Further, it is often the case that high density delivery of humanitarian aid supplies are taken over by non-friendly groups within the affected population. By using direct airdrop systems to deliver large quantities of individually wrapped food and water items, dispersion among the affected disaster relief population will occur more quickly. In this paper, we proffer a multiple criteria decision analysis (MCDA) framework to optimize the military humanitarian assistance/disaster relief (HA/DR) aerial delivery supply chain network. The model uses stochastic, mixed-integer, weighted goal programming to optimize network design, logistics costs, staging locations, procurement amounts, and inventory levels. The MCDA framework enables decision-makers to explore the trade-offs between military HA/DR aerial delivery supply chain efficiency and responsiveness, while optimizing across a wide range of real-world, probabilistic scenarios to account for the inherent uncertainty in the location of global humanitarian disasters as well as the amount of demand to be met.
C1 [Bastian, Nathaniel D.] Penn State Univ, Dept Ind & Mfg Engn, 355 Leonhard Bldg, University Pk, PA 16802 USA.
[Griffin, Paul M.] Georgia Inst Technol, Sch Ind & Syst Engn, 755 Ferst Dr, Atlanta, GA 30332 USA.
[Spero, Eric] US Army, Res Lab, Vehicle Appl Res Div, 4603 Flare Loop, Aberdeen, MD 21005 USA.
[Fulton, Lawrence V.] Texas Tech Univ, Rawls Coll Business Adm, 703 Flint Ave, Lubbock, TX 79410 USA.
RP Bastian, ND (reprint author), Penn State Univ, Dept Ind & Mfg Engn, 355 Leonhard Bldg, University Pk, PA 16802 USA.
EM ndbastian@psu.edu; pgriffin@gatech.edu; eric.spero.civ@mail.mil;
larry.fulton@ttu.edu
FU U.S. Army Research Laboratory; U.S. Army Natick Soldier Research
Development and Engineering Center; National Science Foundation
[DGE1255832]
FX This work is partially supported by the U.S. Army Research Laboratory
and the U.S. Army Natick Soldier Research Development and Engineering
Center. The first author was supported in part by the National Science
Foundation under Grant No. DGE1255832. Any opinions, findings, and
conclusions or recommendations expressed in this material are those of
the authors and do not necessarily reflect the views of the United
States Army, National Science Foundation, Pennsylvania State University,
Georgia Institute of Technology, or Texas Tech University.
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PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1862-4472
EI 1862-4480
J9 OPTIM LETT
JI Optim. Lett.
PD JUN
PY 2016
VL 10
IS 5
SI SI
BP 921
EP 953
DI 10.1007/s11590-015-0888-1
PG 33
WC Operations Research & Management Science; Mathematics, Applied
SC Operations Research & Management Science; Mathematics
GA DN9XV
UT WOS:000377434900004
ER
PT J
AU Paech, GM
Banks, S
Pajcin, M
Grant, C
Johnson, K
Kamimori, GH
Della Vedova, CB
AF Paech, Gemma M.
Banks, Siobhan
Pajcin, Maja
Grant, Crystal
Johnson, Kayla
Kamimori, Gary H.
Della Vedova, Chris B.
TI Caffeine administration at night during extended wakefulness effectively
mitigates performance impairment but not subjective assessments of
fatigue and sleepiness
SO PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
LA English
DT Article
DE Sleep loss; Extended wakefulness; Stimulants; Caffeine; Karolinska
Sleepiness Scale; Psychomotor vigilance task
ID NEUROBEHAVIORAL FUNCTION; COGNITIVE PERFORMANCE; MEDICAL ERRORS;
DEPRIVATION; MOOD; PSYCHOMOTOR; RESTRICTION; MODAFINIL; ALERTNESS;
VIGILANCE
AB The current study investigated the effects of repeated caffeine administration on performance and subjective reports of sleepiness and fatigue during 50 h extended wakefulness. Twenty-four, non-smokers aged 22.5 +/- 2.9 y (mean +/- SD) remained awake for two nights (50 h) in a controlled laboratory environment. During this period, 200 mg of caffeine or placebo gum was administered at 01:00, 03:00, 05:00 and 07:00 on both nights (total of 800 mg/night). Neurobehavioral performance and subjective reports were assessed throughout the wake period. Caffeine improved performance compared to placebo, but did not affect overall ratings of subjective sleepiness and fatigue. Performance and sleepiness worsened with increasing time awake for both conditions. However, caffeine slowed performance impairments such that after 50 h of wakefulness performance was better following caffeine administration compared to placebo. Caffeine also slowed the increase in subjective sleepiness and performance ratings, but only during the first night of wakefulness. After two nights of sleep deprivation, there was no difference in sleepiness ratings between the two conditions. These results demonstrate that strategic administration of caffeine effectively mitigates performance impairments associated with 50 h wakefulness but does not improve overall subjective assessments of sleepiness, fatigue and performance. Results indicate that while performance impairment is alleviated, individuals may continue to report feelings of sleepiness. Individuals who use caffeine as a countermeasure in sustained operations may feel as though caffeine is not effective despite impairments in objective performance being largely mitigated. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Paech, Gemma M.; Banks, Siobhan; Grant, Crystal] Univ S Australia, Ctr Sleep Res, Adelaide, SA 5001, Australia.
[Paech, Gemma M.] Washington State Univ, Sleep & Performance Res Ctr, Spokane, WA USA.
[Paech, Gemma M.] Washington State Univ, Elson S Floyd Coll Med, Spokane, WA USA.
[Pajcin, Maja; Della Vedova, Chris B.] Univ S Australia, Sch Pharm & Med Sci, Adelaide, SA 5001, Australia.
[Johnson, Kayla] Dept Def, Def Sci & Technol Grp, Edinburgh, Australia.
[Kamimori, Gary H.] Walter Reed Army Inst Res, Behav Biol Branch, Silver Spring, MD USA.
RP Paech, GM (reprint author), Sleep & Performance Res Ctr, POB 1495, Spokane, WA 99210 USA.
EM gemma.paech@wsu.edu
RI Banks, Siobhan/L-2149-2013;
OI Banks, Siobhan/0000-0002-7489-0929; Della Vedova,
Chris/0000-0002-2361-3729
FU Defence Science and Technology Organisation, Australian Government,
Department of Defence; US Army Medical Research and Material Command;
ONR [N00014-15-1-0019]
FX The authors thank participants and staff who helped with data
collection, in particular Katja Morsky, Charitha Sayakkarage, Megan
Dittman and Dong Jae Ryoo. We would also like to acknowledge Professor
Gary Wittert, Glen Pierce, Philip Jacques, Justin Fidock and Stephanie
Eonta. This work was supported by the Defence Science and Technology
Organisation, Australian Government, Department of Defence. This work
was also supported by the US Army Medical Research and Material Command.
This material has been reviewed by the Walter Reed Army Institute of
Research, and there is no objection to its presentation and/or
publication. The opinions or assertions contained herein are the private
views of the authors and are not to be construed as official or as
reflecting the position of the Department of the Army of the Department
of Defence. Dr Paech was supported in part by ONR grant N00014-15-1-0019
to Washington State University (PI: D.A. Grant). The authors have no
conflicts of interest to report.
NR 39
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PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0091-3057
J9 PHARMACOL BIOCHEM BE
JI Pharmacol. Biochem. Behav.
PD JUN
PY 2016
VL 145
BP 27
EP 32
DI 10.1016/j.pbb.2016.03.011
PG 6
WC Behavioral Sciences; Neurosciences; Pharmacology & Pharmacy
SC Behavioral Sciences; Neurosciences & Neurology; Pharmacology & Pharmacy
GA DN8JZ
UT WOS:000377326300005
PM 27061779
ER
PT J
AU Perliger, A
Pedahzur, A
AF Perliger, Arie
Pedahzur, Ami
TI Counter Cultures, Group Dynamics and Religious Terrorism
SO POLITICAL STUDIES
LA English
DT Article
DE counter cultures; group dynamics; religious; terrorism
ID BRANCH DAVIDIANS; IDENTITY FUSION; CENTRALITY; CONFLICT; NETWORKS;
ACTIVISM
AB Totalistic ideologies are breeding grounds for radicalization. Communities that adhere to such ideologies tend to rally when they feel threatened by powerful outsiders. Under such circumstances, community leaders become central. If they frame the situation as an existential threat to the community itself or to its most sacred values, they will accelerate the radicalization process and subsequently increase the prospects of violent actions by group members. The shift to violence takes place in the framework of close-knit social networks within the broader radicalized community. These networks consist of individuals who usually live in the same area and engage in continuous interaction among themselves. Such interactions bolster their communal commitment and develop a collective mindset that facilitates the slide of some of the individuals into violence. Those who eventually descend into terrorism usually exhibit strong identification with the community's values and extreme alienation towards the outside world. They also enjoy high levels of biographical availability. These hypotheses are tested using the case study of Jewish terrorism in Israel between 1948 and 2006.
C1 [Perliger, Arie] US Mil Acad, 607 Cullum Rd,Lincoln Hall,Rm 122, West Point, NY 10996 USA.
[Pedahzur, Ami] Univ Texas Austin, Dept Govt, Mailcode A1800, Austin, TX 78712 USA.
RP Perliger, A (reprint author), US Mil Acad, 607 Cullum Rd,Lincoln Hall,Rm 122, West Point, NY 10996 USA.
EM aperliger@gmail.com; pedahzur@austin.utexas.edu
NR 81
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U1 8
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PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0032-3217
EI 1467-9248
J9 POLIT STUD-LONDON
JI Polit. Stud.
PD JUN
PY 2016
VL 64
IS 2
BP 297
EP 314
DI 10.1111/1467-9248.12182
PG 18
WC Political Science
SC Government & Law
GA DN8RK
UT WOS:000377346900003
ER
PT J
AU Convertino, VA
Wirt, MD
Glenn, JF
Lein, BC
AF Convertino, Victor A.
Wirt, Michael D.
Glenn, John F.
Lein, Brian C.
TI THE COMPENSATORY RESERVE FOR EARLY AND ACCURATE PREDICTION OF
HEMODYNAMIC COMPROMISE: A REVIEW OF THE UNDERLYING PHYSIOLOGY
SO SHOCK
LA English
DT Review
DE Hemorrhage; lower body negative pressure; shock; trauma; vital signs
ID BODY NEGATIVE-PRESSURE; GENOME-WIDE ASSOCIATION; TRADITIONAL VITAL
SIGNS; GOAL-DIRECTED THERAPY; SHOCK INDEX; CENTRAL HYPOVOLEMIA;
BLOOD-LOSS; TRAUMA PATIENTS; CARDIAC-OUTPUT; SEPTIC SHOCK
AB Shock is deadly and unpredictable if it is not recognized and treated in early stages of hemorrhage. Unfortunately, measurements of standard vital signs that are displayed on current medical monitors fail to provide accurate or early indicators of shock because of physiological mechanisms that effectively compensate for blood loss. As a result of new insights provided by the latest research on the physiology of shock using human experimental models of controlled hemorrhage, it is now recognized that measurement of the body's reserve to compensate for reduced circulating blood volume is the single most important indicator for early and accurate assessment of shock. We have called this function the "compensatory reserve," which can be accurately assessed by real-time measurements of changes in the features of the arterial waveform. In this paper, the physiology underlying the development and evaluation of a new noninvasive technology that allows for real-time measurement of the compensatory reserve will be reviewed, with its clinical implications for earlier and more accurate prediction of shock.
C1 [Convertino, Victor A.; Wirt, Michael D.] US Army Inst Surg Res, 3698 Chambers Pass,Bldg 3611, Ft Sam Houston, TX 78234 USA.
[Glenn, John F.; Lein, Brian C.] US Army Med Res & Mat Command, Ft Detrick, MD USA.
RP Convertino, VA (reprint author), US Army Inst Surg Res, 3698 Chambers Pass,Bldg 3611, Ft Sam Houston, TX 78234 USA.
EM victor.a.convertino.civ@mail.mil
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PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD JUN
PY 2016
VL 45
IS 6
BP 580
EP 590
DI 10.1097/SHK.0000000000000559
PG 11
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA DO3OB
UT WOS:000377689800002
PM 26950588
ER
PT J
AU Desai, SB
Madhvapathy, SR
Amani, M
Kiriya, D
Hettick, M
Tosun, M
Zhou, YZ
Dubey, M
Ager, JW
Chrzan, D
Javey, A
AF Desai, Sujay B.
Madhvapathy, Surabhi R.
Amani, Matin
Kiriya, Daisuke
Hettick, Mark
Tosun, Mahmut
Zhou, Yuzhi
Dubey, Madan
Ager, Joel W., III
Chrzan, Daryl
Javey, Ali
TI Gold-Mediated Exfoliation of Ultralarge Optoelectronically-Perfect
Monolayers
SO ADVANCED MATERIALS
LA English
DT Article
ID TRANSITION-METAL DICHALCOGENIDES; FIELD-EFFECT TRANSISTORS; LARGE-AREA;
2-DIMENSIONAL MATERIALS; MOS2; GRAPHENE; LAYERS; WSE2; INTERFACE; FILMS
AB Gold-mediated exfoliation of ultralarge optoelectronically perfect monolayers with lateral dimensions up to approximate to 500 mu m is reported. Electrical, optical, and X-ray photo electron spectroscopy characterization show that the quality of the gold-exfoliated flakes is similar to that of tape-exfoliated flakes. Large-area flakes allow manufacturing of large-area monolayer transition metal dichalcogenide electronics.
C1 [Desai, Sujay B.; Madhvapathy, Surabhi R.; Amani, Matin; Kiriya, Daisuke; Hettick, Mark; Tosun, Mahmut; Javey, Ali] Univ Calif Berkeley, Elect Engn & Comp Sci, Berkeley, CA 94720 USA.
[Desai, Sujay B.; Madhvapathy, Surabhi R.; Amani, Matin; Kiriya, Daisuke; Hettick, Mark; Tosun, Mahmut; Ager, Joel W., III; Chrzan, Daryl; Javey, Ali] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Mat Sci, Berkeley, CA 94720 USA.
[Desai, Sujay B.; Amani, Matin; Kiriya, Daisuke; Hettick, Mark; Tosun, Mahmut; Javey, Ali] Univ Calif Berkeley, Berkeley Sensor & Actuator Ctr, Berkeley, CA 94720 USA.
[Zhou, Yuzhi; Ager, Joel W., III; Chrzan, Daryl] Univ Calif Berkeley, Mat Sci & Engn Dept, Berkeley, CA 94720 USA.
[Dubey, Madan] US Army, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20723 USA.
RP Javey, A (reprint author), Univ Calif Berkeley, Elect Engn & Comp Sci, Berkeley, CA 94720 USA.; Javey, A (reprint author), Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Mat Sci, Berkeley, CA 94720 USA.; Javey, A (reprint author), Univ Calif Berkeley, Berkeley Sensor & Actuator Ctr, Berkeley, CA 94720 USA.
EM ajavey@eecs.berkeley.edu
FU Electronics Materials program - Office of Science, Office of Basic
Energy Sciences, Material Sciences and Engineering Division of the U.S.
Department of Energy [DE-AC02-05CH11231]; Office of Science of the U.S.
Department of Energy [DE-SC0004993]
FX S.B.D., S.R.M., and M.A. contributed equally to this work. This work was
supported by the Electronics Materials program funded by the Director,
Office of Science, Office of Basic Energy Sciences, Material Sciences
and Engineering Division of the U.S. Department of Energy under Contract
No. DE-AC02-05CH11231. XPS measurements were performed at the Joint
Center for Artificial Photosynthesis (JCAP), a Department of Energy
(DOE) Energy Innovation Hub, supported through the Office of Science of
the U.S. Department of Energy under Award No. DE-SC0004993
NR 28
TC 2
Z9 2
U1 20
U2 42
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 0935-9648
EI 1521-4095
J9 ADV MATER
JI Adv. Mater.
PD JUN 1
PY 2016
VL 28
IS 21
BP 4053
EP 4058
DI 10.1002/adma.201506171
PG 6
WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied;
Physics, Condensed Matter
SC Chemistry; Science & Technology - Other Topics; Materials Science;
Physics
GA DN5PK
UT WOS:000377122400008
PM 27007751
ER
PT J
AU Lanier, JB
Bury, DC
Richardson, SW
AF Lanier, Jeffrey B.
Bury, David C.
Richardson, Sean W.
TI Diet and Physical Activity for Cardiovascular Disease Prevention
SO AMERICAN FAMILY PHYSICIAN
LA English
DT Article
ID FORCE RECOMMENDATION STATEMENT; LONG-CHAIN OMEGA-3-FATTY-ACIDS;
MEDITERRANEAN DIET; HEALTHFUL DIET; UNITED-STATES; SODIUM-INTAKE; FAT
DIETS; METAANALYSIS; RISK; ADULTS
AB Cardiovascular disease (CVD) is the leading cause of death in the United States. One-third of these deaths may be preventable through healthy lifestyle choices including diet and physical activity. The Mediterranean diet is associated with reduced cardiovascular mortality, whereas the Dietary Approaches to Stop Hypertension (DASH) eating plan is associated with a reduced risk of coronary artery disease. Substituting dietary saturated fat with polyunsaturated fatty acids is associated with improved cardiovascular outcomes, although exogenous supplementation with omega-3 fatty acids does not improve cardiovascular outcomes. There is an association between increased sodium intake and cardiovascular risk, but reducing dietary sodium has not consistently shown a reduction in cardiovascular risk. Physical activity recommendations for adults are at least 150 minutes of moderate-intensity aerobic activity per week, 75 minutes of vigorous-intensity aerobic activity per week, or an equivalent combination. Increases in physical activity by any level are associated with reduced cardiovascular risk. Introducing muscle-strengthening activities at least twice per week in previously inactive adults is associated with improved cardiovascular outcomes. Inactive adults without known CVD can gradually increase activity to a moderate-intensity level without consulting a physician. The U.S. Preventive Services Task Force recommends behavioral counseling to promote healthy diet and physical activity in adults at high risk of CVD. Evidence of benefit for counseling patients at average risk is less established. Copyright (C) 2016 American Academy of Family Physicians.
C1 [Lanier, Jeffrey B.] US Army, Recruiting Command, Ft Knox, KY USA.
[Bury, David C.] US Army, Hlth Clin, Camp Casey, South Korea.
[Richardson, Sean W.] Martin Army Community Hosp, Family Med Residency Program, Ft Benning, GA USA.
RP Lanier, JB (reprint author), US Army Med Recruiting Brigade, 1889 Old Ironsides Ave, Ft Knox, KY 40121 USA.
EM jeffrey.b.lanier.mil@mail.mil
NR 34
TC 1
Z9 1
U1 8
U2 14
PU AMER ACAD FAMILY PHYSICIANS
PI KANSAS CITY
PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA
SN 0002-838X
EI 1532-0650
J9 AM FAM PHYSICIAN
JI Am. Fam. Physician
PD JUN 1
PY 2016
VL 93
IS 11
BP 919
EP 924
PG 6
WC Primary Health Care; Medicine, General & Internal
SC General & Internal Medicine
GA DN1LE
UT WOS:000376826500005
PM 27281836
ER
PT J
AU Hinojosa-Laborde, C
Howard, JT
Mulligan, J
Grudic, GZ
Convertino, VA
AF Hinojosa-Laborde, Carmen
Howard, Jeffrey T.
Mulligan, Jane
Grudic, Greg Z.
Convertino, Victor A.
TI Comparison of compensatory reserve during lower-body negative pressure
and hemorrhage in nonhuman primates
SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE
PHYSIOLOGY
LA English
DT Article
DE blood loss; central hypovolemia; stroke volume; blood pressure;
compensatory mechanisms
ID COMBAT CASUALTY CARE; BLOOD-LOSS; CENTRAL HYPOVOLEMIA; CARDIAC-OUTPUT;
STROKE VOLUME; TOLERANCE; PROGRESSION; RESPONSES; HUMANS; DEATH
AB Compensatory reserve was measured in baboons (n = 13) during hemorrhage (Hem) and lower-body negative pressure (LBNP) using a machine-learning algorithm developed to estimate compensatory reserve by detecting reductions in central blood volume during LBNP. The algorithm calculates compensatory reserve index (CRI) from normovolemia (CRI = 1) to cardiovascular decompensation (CRI = 0). The hypothesis was that Hem and LBNP will elicit similar CRI values and that CRI would have higher specificity than stroke volume (SV) in predicting decompensation. Blood was removed in four steps: 6.25%, 12.5%, 18.75%, and 25% of total blood volume. Four weeks after Hem, the same animals were subjected to four levels of LBNP that was matched on the basis of their central venous pressure. Data (mean +/- 95% confidence interval) indicate that CRI decreased (P < 0.001) from baseline during Hem (0.69 +/- 0.10, 0.57 +/- 0.09, 0.36 +/- 0.10, 0.16 +/- 0.08, and 0.08 +/- 0.03) and LBNP (0.76 +/- 0.05, 0.66 +/- 0.08, 0.36 +/- 0.13, 0.23 +/- 0.11, and 0.14 +/- 0.09). CRI was not different between Hem and LBNP (P = 0.20). Linear regression analysis between Hem CRI and LBNP CRI revealed a slope of 1.03 and a correlation coefficient of 0.96. CRI exhibited greater specificity than SV in both Hem (92.3 vs. 82.1) and LBNP (94.8 vs. 83.1) and greater ROC AUC in Hem (0.94 vs. 0.84) and LBNP (0.94 vs. 0.92). These data support the hypothesis that Hem and LBNP elicited the same CRI response, suggesting that measurement of compensatory reserve is superior to SV as a predictor of cardiovascular decompensation
C1 [Hinojosa-Laborde, Carmen; Howard, Jeffrey T.; Convertino, Victor A.] US Army, Inst Surg Res, Joint Base San Antonio F, TX USA.
[Mulligan, Jane; Grudic, Greg Z.] Flashback Technol, Boulder, CO USA.
RP Hinojosa-Laborde, C (reprint author), US Army, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.
EM carmen.hinojosa-laborde.civ@mail.mil
FU U.S. Army Medical Research and Materiel Command Combat Casualty Care
Research Program; Oak Ridge Institute of Science and Education
FX This research was supported by funding from the U.S. Army Medical
Research and Materiel Command Combat Casualty Care Research Program and
in part by a postdoctoral fellowship provided by the Oak Ridge Institute
of Science and Education. We thank Gary Muniz from U.S. Army Institute
of Surgical Research; and Dr. Robert E. Shade and Dr. Cassondra Bauer
from the Texas Biomedical Research Institute for their technical
contributions to this study.
NR 29
TC 0
Z9 0
U1 1
U2 3
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6119
EI 1522-1490
J9 AM J PHYSIOL-REG I
JI Am. J. Physiol.-Regul. Integr. Comp. Physiol.
PD JUN 1
PY 2016
VL 310
IS 11
BP R1154
EP R1159
DI 10.1152/ajpregu.00304.2015
PG 6
WC Physiology
SC Physiology
GA DN4GK
UT WOS:000377021700016
PM 27030667
ER
PT J
AU Reiter, MJ
Schwope, RB
Theler, JM
AF Reiter, Michael J.
Schwope, Ryan B.
Theler, Jared M.
TI Postoperative CT of the Orbital Skeleton After Trauma: Review of Normal
Appearances and Common Complications
SO AMERICAN JOURNAL OF ROENTGENOLOGY
LA English
DT Review
DE orbital fracture; postsurgical orbit; zygomaticomaxillary complex
fracture
ID COMPUTED-TOMOGRAPHY; FLOOR FRACTURES; MAXILLOFACIAL TRAUMA; MIDFACE
FRACTURES; WALL FRACTURES; SURGEON NEEDS; RECONSTRUCTION; MANAGEMENT;
REPAIR; RADIOGRAPHS
AB OBJECTIVE. The purpose of this article is to describe both the expected and unexpected imaging features of posttraumatic defects of the orbital skeleton after surgical repair.
CONCLUSION. The goal of surgery is to restore the preinjury orbital anatomy to improve function and prevent enophthalmos. Radiologists need to be cognizant of the more frequently encountered operative procedures used for orbital fracture repair, the desired goals of treatment, and common complications. This will permit accurate interpretation of postoperative CT and provide surgeons with clinically useful results.
C1 [Reiter, Michael J.] SUNY Stony Brook, Med Ctr, Dept Radiol, HSC Level 4,Rm 120,East Loop Rd, Stony Brook, NY 11794 USA.
[Schwope, Ryan B.] Brooke Army Med Ctr, Dept Radiol, San Antonio, TX USA.
[Schwope, Ryan B.] Uniformed Serv Univ Hlth Sci, Dept Radiol, Bethesda, MD 20814 USA.
[Theler, Jared M.] Brooke Army Med Ctr, Dept Otolaryngol, San Antonio, TX USA.
RP Reiter, MJ (reprint author), SUNY Stony Brook, Med Ctr, Dept Radiol, HSC Level 4,Rm 120,East Loop Rd, Stony Brook, NY 11794 USA.
EM mikereiter13@yahoo.com
NR 45
TC 0
Z9 0
U1 2
U2 2
PU AMER ROENTGEN RAY SOC
PI RESTON
PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA
SN 0361-803X
EI 1546-3141
J9 AM J ROENTGENOL
JI Am. J. Roentgenol.
PD JUN
PY 2016
VL 206
IS 6
BP 1276
EP 1285
DI 10.2214/AJR.15.15477
PG 10
WC Radiology, Nuclear Medicine & Medical Imaging
SC Radiology, Nuclear Medicine & Medical Imaging
GA DN2XW
UT WOS:000376927300030
PM 27010378
ER
PT J
AU Garcia-Reyero, N
AF Garcia-Reyero, Natalia
TI Advancing Ecotoxicology in the US Southern States
SO BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
LA English
DT Editorial Material
C1 [Garcia-Reyero, Natalia] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA.
[Garcia-Reyero, Natalia] Mississippi State Univ, IGBB, Starkville, MS USA.
RP Garcia-Reyero, N (reprint author), US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA.; Garcia-Reyero, N (reprint author), Mississippi State Univ, IGBB, Starkville, MS USA.
EM Natalia.G.Vinas@erdc.dren.mil
NR 0
TC 1
Z9 1
U1 1
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0007-4861
EI 1432-0800
J9 B ENVIRON CONTAM TOX
JI Bull. Environ. Contam. Toxicol.
PD JUN
PY 2016
VL 96
IS 6
BP 705
EP 706
DI 10.1007/s00128-016-1824-5
PG 2
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA DN3SR
UT WOS:000376984200001
PM 27209542
ER
PT J
AU Garcia-Reyero, N
Escalon, L
Prats, E
Faria, M
Soares, AMVM
Raldua, D
AF Garcia-Reyero, Natalia
Escalon, Lynn
Prats, Eva
Faria, Melissa
Soares, Amadeu M. V. M.
Raldua, Demetrio
TI Targeted Gene Expression in Zebrafish Exposed to Chlorpyrifos-Oxon
Confirms Phenotype-Specific Mechanisms Leading to Adverse Outcomes
SO BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
LA English
DT Article
DE Zebrafish; Gene expression; Oxidative stress; Mitochondria;
Chlorpyrifos-oxon
ID OXIDATIVE STRESS; CELL-DEATH; CALCIUM; PESTICIDE; MITOCHONDRIA
AB Zebrafish models for mild, moderate, and severe acute organophosphorus poisoning were previously developed by exposing zebrafish larvae to chlopyrifos-oxon. The phenotype of these models was characterized at several levels of biological organization. Oxidative stress and mitochondrial dysfunction were found to be involved in the development of the more severe phenotype. Here we used targeted gene expression to understand the dose-responsiveness of those two pathways and their involvement on generating the different zebrafish models. As the severe phenotype is irreversible after only 3 h of exposure, we also analyzed the response of the oxidative stress pathway at 3 and 24 h. Some of the genes related to oxidative stress were already differentially expressed at 3 h. There was an increase in differentially expressed genes related to both oxidative stress and mitochondrial function from the more mild to the more severe phenotype, suggesting the involvement of these mechanisms in increasing phenotype severity. Temporal data suggest that peroxynitrite leading to lipid peroxidation might be involved in phenotype transition and irreversibility.
C1 [Garcia-Reyero, Natalia; Escalon, Lynn] US Army Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
[Garcia-Reyero, Natalia] Mississippi State Univ, Inst Genom Biocomp & Biotechnol, 2 Res Blvd, Starkville, MS 39759 USA.
[Prats, Eva] CSIC, CIC, Jordi Girona 18, ES-08034 Barcelona, Spain.
[Faria, Melissa; Soares, Amadeu M. V. M.] Univ Aveiro, Dept Biol, P-3800 Aveiro, Portugal.
[Faria, Melissa; Soares, Amadeu M. V. M.] Univ Aveiro, CESAM, P-3800 Aveiro, Portugal.
[Faria, Melissa; Raldua, Demetrio] CSIC, IDAEA, Jordi Girona 18, ES-08034 Barcelona, Spain.
RP Garcia-Reyero, N (reprint author), US Army Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.; Garcia-Reyero, N (reprint author), Mississippi State Univ, Inst Genom Biocomp & Biotechnol, 2 Res Blvd, Starkville, MS 39759 USA.
EM natalia.g.vinas@erdc.dren.mil
RI CESAM, UA/M-3762-2015; Soares, Amadeu/A-8304-2008;
OI Soares, Amadeu/0000-0003-0879-9470; Raldua, Demetrio/0000-0001-5256-1641
FU US Army ERDC-IRO [W912HZ-13-BAA-01]; Environmental Quality Research
Program; NATO SfP project [MD.SFPP 984777]; National Science Foundation
EPSCoR Grant [EPS-0903787]
FX This work was supported in part by the US Army ERDC-IRO
(W912HZ-13-BAA-01; D.R., N.G.R.) and Environmental Quality Research
Program (N.G.R.), the NATO SfP project MD.SFPP 984777 (D.R., N.G.R.),
and the National Science Foundation EPSCoR Grant EPS-0903787 (N.G.R.).
NR 21
TC 0
Z9 0
U1 4
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0007-4861
EI 1432-0800
J9 B ENVIRON CONTAM TOX
JI Bull. Environ. Contam. Toxicol.
PD JUN
PY 2016
VL 96
IS 6
BP 707
EP 713
DI 10.1007/s00128-016-1798-3
PG 7
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA DN3SR
UT WOS:000376984200002
PM 27086301
ER
PT J
AU Butler, AD
Wynter, M
Medina, VF
Bednar, AJ
AF Butler, Afrachanna D.
Wynter, Michelle
Medina, Victor F.
Bednar, Anthony J.
TI Depleted Uranium Toxicity, Accumulation, and Uptake in Cynodon dactylon
(Bermuda) and Aristida purpurea (Purple Threeawn)
SO BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
LA English
DT Article
DE Depleted uranium; Phyto-toxicity; Phytouptake; Translocation;
Bioconcentration
ID 3 GRASSES; SOIL; TRANSLOCATION; SPECIATION; GRADE
AB Yuma Proving Grounds (YPG) in western Arizona is a testing range where Depleted uranium (DU) penetrators have been historically fired. A portion of the fired DU penetrators are being managed under controlled conditions by leaving them in place. The widespread use of DU in armor-penetrating weapons has raised environmental and human health concerns. The present study is focused on the onsite management approach and on the potential interactions with plants local to YPG. A 30 day study was conducted to assess the toxicity of DU corrosion products (e.g., schoepite and meta-schoepite) in two grass species that are native to YPG, Bermuda (Cynodon dactylon) and Purple Threeawn (Aristida purpurea). In addition, the ability for plants to uptake DU was studied. The results of this study show a much lower threshold for biomass toxicity and higher plant concentrations, particularly in the roots than shoots, compared to previous studies.
C1 [Butler, Afrachanna D.; Wynter, Michelle; Medina, Victor F.; Bednar, Anthony J.] US Army Engineer Res & Dev Ctr ERDC, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS USA.
RP Butler, AD (reprint author), US Army Engineer Res & Dev Ctr ERDC, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS USA.
EM Afrachanna.D.Butler@usace.army.mil
NR 33
TC 0
Z9 0
U1 6
U2 8
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0007-4861
EI 1432-0800
J9 B ENVIRON CONTAM TOX
JI Bull. Environ. Contam. Toxicol.
PD JUN
PY 2016
VL 96
IS 6
BP 714
EP 719
DI 10.1007/s00128-016-1784-9
PG 6
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA DN3SR
UT WOS:000376984200003
PM 27016940
ER
PT J
AU Russell, AL
Martin, DP
Cuddy, MF
Bednar, AJ
AF Russell, Amber L.
Martin, David P.
Cuddy, Michael F.
Bednar, Anthony J.
TI A Rapid, Fluorescence-Based Field Screening Technique for Organic
Species in Soil and Water Matrices
SO BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
LA English
DT Article
DE Field analysis; Oil screening; Rapid detection
ID AROMATIC-HYDROCARBONS PAHS; OIL
AB Real-time detection of hydrocarbon contaminants in the environment presents analytical challenges because traditional laboratory-based techniques are cumbersome and not readily field portable. In the current work, a method for rapid and semi-quantitative detection of organic contaminants, primarily crude oil, in natural water and soil matrices has been developed. Detection limits in the parts per million and parts per billion were accomplished when using visual and digital detection methods, respectively. The extraction technique was modified from standard methodologies used for hydrocarbon analysis and provides a straight-forward separation technique that can remove interference from complex natural constituents. For water samples this method is semi-quantitative, with recoveries ranging from 70 % to 130 %, while measurements of soil samples are more qualitative due to lower extraction efficiencies related to the limitations of field-deployable procedures.
C1 [Russell, Amber L.; Martin, David P.; Cuddy, Michael F.; Bednar, Anthony J.] US Army, Environm Lab, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
RP Bednar, AJ (reprint author), US Army, Environm Lab, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM Anthony.J.Bednar@usace.army.mil
NR 16
TC 0
Z9 0
U1 1
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0007-4861
EI 1432-0800
J9 B ENVIRON CONTAM TOX
JI Bull. Environ. Contam. Toxicol.
PD JUN
PY 2016
VL 96
IS 6
BP 773
EP 778
DI 10.1007/s00128-016-1771-1
PG 6
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA DN3SR
UT WOS:000376984200013
PM 26988223
ER
PT J
AU Burgoon, LD
AF Burgoon, Lyle D.
TI A Market-Basket Approach to Predict the Acute Aquatic Toxicity of
Munitions and Energetic Materials
SO BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
LA English
DT Article
DE Computational toxicology; Quantitative structure activity relationship;
Aquatic toxicology; QSAR; Predictive toxicology; Munitions; Energetics;
Fish toxicity; Acute toxicity
AB An ongoing challenge in chemical production, including the production of insensitive munitions and energetics, is the ability to make predictions about potential environmental hazards early in the process. To address this challenge, a quantitative structure activity relationship model was developed to predict acute fathead minnow toxicity of insensitive munitions and energetic materials. Computational predictive toxicology models like this one may be used to identify and prioritize environmentally safer materials early in their development. The developed model is based on the Apriori market-basket/frequent itemset mining approach to identify probabilistic prediction rules using chemical atom-pairs and the lethality data for 57 compounds from a fathead minnow acute toxicity assay. Lethality data were discretized into four categories based on the Globally Harmonized System of Classification and Labelling of Chemicals. Apriori identified toxicophores for categories two and three. The model classified 32 of the 57 compounds correctly, with a fivefold cross-validation classification rate of 74 %. A structure-based surrogate approach classified the remaining 25 chemicals correctly at 48 %. This result is unsurprising as these 25 chemicals were fairly unique within the larger set.
C1 [Burgoon, Lyle D.] US Army, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
RP Burgoon, LD (reprint author), US Army, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM lyle.d.burgoon@usace.army.mil
OI Burgoon, Lyle/0000-0003-4977-5352
FU U.S. Army Environmental Quality/Installation Technology Research Program
FX Permission for publishing this information has been granted by the Chief
of Engineers. Thanks to Drs. Natalia Vinas and Ed Perkins for comments
on an earlier draft of this manuscript. The U.S. Army Environmental
Quality/Installation Technology Research Program funded this work as
part of the Rapid Hazard Assessment Focus Area.
NR 6
TC 0
Z9 0
U1 1
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0007-4861
EI 1432-0800
J9 B ENVIRON CONTAM TOX
JI Bull. Environ. Contam. Toxicol.
PD JUN
PY 2016
VL 96
IS 6
BP 779
EP 783
DI 10.1007/s00128-016-1800-0
PG 5
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA DN3SR
UT WOS:000376984200014
PM 27091326
ER
PT J
AU Shukla, MK
Poda, A
AF Shukla, Manoj K.
Poda, Aimee
TI Adsorption of Emerging Munitions Contaminants on Cellulose Surface: A
Combined Theoretical and Experimental Investigation
SO BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
LA English
DT Article
DE 2,4-dinitroanisole (DNAN); 1,1-diamino-2,2-dinitroethene (FOX-7);
2,4,6-trinitrotoluene (TNT); Cellulose; Adsorption; DFT level
ID QUARTZ-CRYSTAL MICROBALANCE; ENERGIES; FIBERS; FILMS; MODEL; TOOL
AB This manuscript reports results of an integrated theoretical and experimental investigation of adsorption of two emerging contaminants (DNAN and FOX-7) and legacy compound TNT on cellulose surface. Cellulose was modeled as trimeric form of the linear chain of 1 -> 4 linked of beta-D-glucopyranos in C-4(1) chair conformation. Geometries of modeled cellulose, munitions compounds and their complexes were optimized at the M06-2X functional level of Density Functional Theory using the 6-31G(d,p) basis set in gas phase and in water solution. The effect of water solution was modeled using the CPCM approach. Nature of potential energy surfaces was ascertained through harmonic vibrational frequency analysis. Interaction energies were corrected for basis set superposition error and the 6-311G(d,p) basis set was used. Molecular electrostatic potential mapping was performed to understand the reactivity of the investigated systems. It was predicted that adsorbates will be weakly adsorbed on the cellulose surface in water solution than in the gas phase.
C1 [Shukla, Manoj K.; Poda, Aimee] Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
RP Shukla, MK (reprint author), Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
EM Manoj.K.Shukla@usace.army.mil
RI Poda, Aimee/K-1905-2012
NR 18
TC 0
Z9 0
U1 7
U2 9
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0007-4861
EI 1432-0800
J9 B ENVIRON CONTAM TOX
JI Bull. Environ. Contam. Toxicol.
PD JUN
PY 2016
VL 96
IS 6
BP 784
EP 790
DI 10.1007/s00128-016-1791-x
PG 7
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA DN3SR
UT WOS:000376984200015
PM 27084096
ER
PT J
AU Medina, VF
Griggs, CS
Thomas, C
AF Medina, Victor F.
Griggs, Chris S.
Thomas, Catherine
TI Evaluation of the Destruction of the Harmful Cyanobacteria, Microcystis
aeruginosa, with a Cavitation and Superoxide Generating Water Treatment
Reactor
SO BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
LA English
DT Article
DE Cyanobacterial/harmful algal blooms (CHAB); Cyanobacteria; Microcystin;
Superoxide; Cavitation
ID HYDRODYNAMIC CAVITATION; TOXINS; LAKES; MECHANISMS; REMOVAL
AB Cyanobacterial/Harmful Algal Blooms are a major issue for lakes and reservoirs throughout the U.S.A. An effective destructive technology could be useful to protect sensitive areas, such as areas near water intakes. The study presented in this article explored the use of a reactor called the KRIA Water Treatment System. The reactor focuses on the injection of superoxide (O-2 (-)), which is generated electrochemically from the atmosphere, into the water body. In addition, the injection process generates a significant amount of cavitation. The treatment process was tested in 190-L reactors spiked with water from cyanobacterial contaminated lakes. The treatment was very effective at destroying the predominant species of cyanobacteria, Microcystis aeruginosa, organic matter, and decreasing chlorophyll concentration. Microcystin toxin concentrations were also reduced. Data suggest that cavitation alone was an effective treatment, but the addition of superoxide improved performance, particularly regarding removal of cyanobacteria and reduction of microcystin concentration.
C1 [Medina, Victor F.; Griggs, Chris S.; Thomas, Catherine] US Army, Engineer Res & Dev Ctr, CEERD EPE, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
RP Medina, VF (reprint author), US Army, Engineer Res & Dev Ctr, CEERD EPE, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM victor.f.medina@usace.army.mil
FU Premier Materials Technology, Inc. of Minneapolis, MN; Aquatic Plant
Control Research Program
FX The authors would like to acknowledge the support of Premier Materials
Technology, Inc. of Minneapolis, MN, who funded the project and the time
to prepare this paper. Mr. Keith Boulais, CEO, was our primary contact.
We also acknowledge the support by Mr. Mike Mangham of ECOUSA, who
provided information on the operation of the KRIA reactor. A follow on
project was funded by the Aquatic Plant Control Research Program, and
some supplementary data were provided via this effort.
NR 22
TC 0
Z9 0
U1 6
U2 12
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0007-4861
EI 1432-0800
J9 B ENVIRON CONTAM TOX
JI Bull. Environ. Contam. Toxicol.
PD JUN
PY 2016
VL 96
IS 6
BP 791
EP 796
DI 10.1007/s00128-016-1742-6
PG 6
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA DN3SR
UT WOS:000376984200016
PM 26846314
ER
PT J
AU Martin, S
AF Martin, Sarah
TI "Elementar, meu caro Watson": Jo Soares Reinvents the Classics
SO HISPANIA-A JOURNAL DEVOTED TO THE TEACHING OF SPANISH AND PORTUGUESE
LA English
DT Article
DE Brazil/Brasil; carnivalesque/carnavalesco; detective fiction/romance
policial; Jo Soares; mysteries/misterios; parody/parodia; Sherlock
Holmes
AB Detective fiction with its roots primarily in Europe and the United States was slow to catch on in Brazil, where national authors did not attempt more than small forays into the genre for most of the twentieth century. This was due in large part to the particularities of Brazilian society, in which law enforcement agencies, rife with corruption, perpetuated the idea that a hero detective who dedicated himself to solving a crime was very foreign. The 1960s saw more Brazilian authors writing detective fiction. A boom in detective literature took place in the 1990s when the end of the dictatorship caused a relaxation of censorship. Among these authors was Jo Soares, whose 1995 novel O xango de Baker Street not only places a classical whodunit on Brazilian soil, but also adapts an icon of the genre, Sherlock Holmes, to Brazilian society. By using the Brazilian idea of the carnivalesque, Soares inverts the typical role of Holmes and reinvents the character in a decidedly Brazilian detective novel, rather than merely modifying the British format.
C1 [Martin, Sarah] US Mil Acad, West Point, NY 10996 USA.
RP Martin, S (reprint author), US Mil Acad, West Point, NY 10996 USA.
NR 18
TC 0
Z9 0
U1 0
U2 2
PU AMER ASSOC TEACHERS SPANISH PORTUGUESE, INC
PI WALLED LAKE
PA 900 LADD RD, WALLED LAKE, MI 48390 USA
SN 0018-2133
EI 2153-6414
J9 HISPANIA-J DEV INTER
JI Hispania-J. Devoted Teach. Span. Port.
PD JUN
PY 2016
VL 99
IS 2
BP 203
EP 211
PG 9
WC Linguistics; Language & Linguistics; Literature, Romance
SC Linguistics; Literature
GA DN6AE
UT WOS:000377152200003
ER
PT J
AU Eberly, JO
Indest, KJ
Hancock, DE
Jung, CM
Crocker, FH
AF Eberly, Jed O.
Indest, Karl J.
Hancock, Dawn E.
Jung, Carina M.
Crocker, Fiona H.
TI Metagenomic analysis of denitrifying wastewater enrichment cultures able
to transform the explosive, 3-nitro-1,2,4-triazol-5-one (NTO)
SO JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
LA English
DT Article
DE NTO; Insensitive munitions; Metagenomics; Denitrification
ID NITRATE-CONTAMINATED GROUNDWATER; AUTOTROPHIC DENITRIFICATION;
HETEROTROPHIC DENITRIFICATION; BIOLOGICAL DENITRIFICATION; MICROBIAL
DIVERSITY; BATCH EXPERIMENTS; STRAIN KTR9; REMOVAL; BIODEGRADATION;
REMEDIATION
AB Removal of 3-nitro-1,2,4-triazol-5-one (NTO) was investigated in conjunction with heterotrophic and autotrophic denitrifying growth conditions by a microbial consortium from a wastewater treatment plant. Microcosms were supplemented with molasses, methanol, or thiosulfate. Cultures were passaged twice by transferring 10 % of the culture volume to fresh media on days 11 and 21. Rates of NTO removal were 18.71 +/- 0.65, 9.04 +/- 2.61, and 4.34 +/- 2.72 mg/L/day while rates of nitrate removal were 20.08 +/- 1.13, 21.58 +/- 1.20, and 24.84 +/- 1.26 mg/L/day, respectively, for molasses, methanol, or thiosulfate. Metagenomic analysis showed that Proteobacteria and Firmicutes were the major phyla in the microbial communities. In molasses supplemented cultures, the community profile at the family level changed over time with Pseudomonadaceae the most abundant (67.4 %) at day 11, Clostridiaceae (65.7 %) at day 21, and Sporolactobacillaceae (35.4 %) and Clostridiaceae (41.0 %) at day 29. Pseudomonadaceae was the dominant family in methanol and thiosulfate supplemented cultures from day 21 to 29 with 76.6 and 81.6 % relative abundance, respectively.
C1 [Eberly, Jed O.; Indest, Karl J.; Hancock, Dawn E.; Jung, Carina M.; Crocker, Fiona H.] US Army, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
RP Indest, KJ (reprint author), US Army, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
EM Karl.J.Indest@usace.army.mil
FU US Army Corps of Engineers Environmental Quality Program
FX This research was funded through the US Army Corps of Engineers
Environmental Quality Program. Views, opinions and/or findings contained
herein are those of the authors and should not be construed as an
official Department of the Army position or decision, unless so
designated by other official documentation.
NR 42
TC 0
Z9 0
U1 7
U2 11
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1367-5435
EI 1476-5535
J9 J IND MICROBIOL BIOT
JI J. Ind. Microbiol. Biotechnol.
PD JUN
PY 2016
VL 43
IS 6
BP 795
EP 805
DI 10.1007/s10295-016-1755-5
PG 11
WC Biotechnology & Applied Microbiology
SC Biotechnology & Applied Microbiology
GA DN2ZA
UT WOS:000376930500007
PM 27033535
ER
PT J
AU Jobe, O
Trinh, HV
Kim, J
Alsalmi, W
Tovanabutra, S
Ehrenberg, PK
Peachman, KK
Gao, GF
Thomas, R
Kim, JH
Michael, NL
Alving, CR
Rao, VB
Rao, M
AF Jobe, Ousman
Trinh, Hung V.
Kim, Jiae
Alsalmi, Wadad
Tovanabutra, Sodsai
Ehrenberg, Philip K.
Peachman, Kristina K.
Gao, Guofen
Thomas, Rasmi
Kim, Jerome H.
Michael, Nelson L.
Alving, Carl R.
Rao, Venigalla B.
Rao, Mangala
TI Effect of cytokines on Siglec-1 and HIV-1 entry in monocyte-derived
macrophages: the importance of HIV-1 envelope V1V2 region
SO JOURNAL OF LEUKOCYTE BIOLOGY
LA English
DT Article
ID HUMAN-IMMUNODEFICIENCY-VIRUS; COLONY-STIMULATING FACTORS; NEUTRALIZING
ANTIBODY PG9; TYPE-1; INFECTION; SIALOADHESIN; TRANSMISSION;
REPLICATION; DIFFERENTIATION; SUSCEPTIBILITY
AB Monocytes and monocyte-derived macrophages express relatively low levels of CD4. Despite this, macrophages can be effectively infected with human immunodeficiency virus type 1. Macrophages have a critical role in human immunodeficiency virus type 1 transmission; however, the mechanism or mechanisms of virus infection are poorly understood. We report that growth factors, such as granulocyte macrophage colony -stimulating factor and macrophage colony stimulating factor affect the phenotypic profile and permissiveness of macrophages to human immunodeficiency virus type 1. Human immunodeficiency virus type 1 infection of monocyte-derived macrophages derived from granulocyte macrophage and macrophage colony stimulating factors was predominantly facilitated by the sialic acid-binding immunoglobulin-like lectin-1. The number of sialic acid-binding immunoglobulin-like lectin receptors on macrophage colony -stimulating factor derived monocyte-derived macrophages was significantly greater than on granulocyte macrophage colony stimulating factor-derived monocyte-derived macrophages, and correspondingly, human immunodeficiency virus type 1 infection was greater in the macrophage colony -stimulating factor-derived monocyte-derived macrophages. Single-genome analysis and quantitative reverse transcriptase-polymerase chain reaction revealed that the differences in infectivity was not due to differences in viral fitness or in viral variants with differential infectivity but was due to reduced viral entry into the granulocyte macrophage colony -stimulating factor derived monocyte-derived macrophages. Anti-sialic acid binding immunoglobulin-like lectin, trimeric glycoprotein 145, and scaffolded V1V2 proteins were bound to sialic acid-binding immunoglobulin-like lectin and significantly reduced human immunodeficiency virus type 1 entry and infection. Furthermore, sialic acid residues present in the V1V2 region of the envelope protein mediated human immunodeficiency virus type 1 interaction with sialic acid-binding immunoglobulin-like lectin and entry into macrophage colony-stimulating factor-derived monocyte-derived macrophages. Removal of sialic acid residues or glycans from scaffolded V1V2 protein decreased human immunodeficiency virus type 1 infectivity. These results highlight the importance of sialic acids on the V1V2 region in binding to sialic acid -binding immunoglobulin-like lectin and suggest that the unusually long surface -exposed sialic acid -binding immunoglobulinlike lectin might aid in the capture and entry of human immunodeficiency virus type 1 into monocyte-derived macrophages.
C1 [Jobe, Ousman; Trinh, Hung V.; Kim, Jiae; Tovanabutra, Sodsai; Ehrenberg, Philip K.; Peachman, Kristina K.; Gao, Guofen] Walter Reed Army Inst Res, Henry M Jackson Fdn Adv Mil Med, Silver Spring, MD USA.
[Jobe, Ousman; Trinh, Hung V.; Kim, Jiae; Peachman, Kristina K.; Alving, Carl R.; Rao, Mangala] Walter Reed Army Inst Res, Lab Adjuvant & Antigen Res, Silver Spring, MD 20910 USA.
[Tovanabutra, Sodsai; Kim, Jerome H.; Michael, Nelson L.] Walter Reed Army Inst Res, Lab Mol Virol & Pathogenesis, Viral Sequencing Core, Silver Spring, MD USA.
[Ehrenberg, Philip K.; Thomas, Rasmi] Walter Reed Army Inst Res, US Mil HIV Res Program, Host Genet Sect, Silver Spring, MD USA.
[Alsalmi, Wadad; Gao, Guofen; Rao, Venigalla B.] Catholic Univ Amer, Dept Biol, Washington, DC 20064 USA.
RP Rao, M (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Lab Adjuvant & Antigen Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM mrao@hivresearch.org
FU Swiss National Science Foundation; U.S. National Institutes of Health
National Institute of Allergy and Infectious Diseases [AI102725]; Henry
M. Jackson Foundation for the Advancement of Military Medicine, Inc.
[W81XWH-11-2-0174]; U.S. Department of Defense
FX H.V.T. was partially supported by a grant from the Swiss National
Science Foundation. V.B.R. was partially supported by the U.S. National
Institutes of Health National Institute of Allergy and Infectious
Diseases (Grant AI102725). This work was supported by a cooperative
agreement (W81XWH-11-2-0174) between the Henry M. Jackson Foundation for
the Advancement of Military Medicine, Inc., and the U.S. Department of
Defense. We thank Kultida Poltavee for sequence analysis, Gustavo Kijak
and Peter Phuc Pham for their assistance with phylogenetic analysis,
Agnes-Laurence Chenine for providing the envelope-deficient HIV-1
(pSG3Delta env), and Sayali Onkar for her assistance in
generating MDMs.
NR 54
TC 1
Z9 1
U1 2
U2 3
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0741-5400
EI 1938-3673
J9 J LEUKOCYTE BIOL
JI J. Leukoc. Biol.
PD JUN
PY 2016
VL 99
IS 6
BP 1089
EP 1106
DI 10.1189/jlb.2A0815-361R
PG 18
WC Cell Biology; Hematology; Immunology
SC Cell Biology; Hematology; Immunology
GA DN2IN
UT WOS:000376887400028
PM 26667473
ER
PT J
AU Kumar, A
Hage-Hassan, J
Baskaran, M
Miller, CJ
Selegean, JP
Creech, CT
AF Kumar, A.
Hage-Hassan, J.
Baskaran, M.
Miller, C. J.
Selegean, J. P.
Creech, C. T.
TI Multiple sediment cores from reservoirs are needed to reconstruct recent
watershed changes from stable isotopes (delta C-13 and delta N-15) and
C/N ratios: case studies from the mid-western United States
SO JOURNAL OF PALEOLIMNOLOGY
LA English
DT Article
DE Pb-210 and Cs-137 chronology; Sediment dating; Stable carbon and
nitrogen isotopes; Reservoir sediment; Paleoenvironmental changes
ID ENVIRONMENTAL-CHANGES; GEOCHEMICAL RECORD; ORGANIC-MATTER;
LAKE-SEDIMENTS; EXCESS PB-210; CS-137; MICHIGAN; RATES; BE-7;
RADIONUCLIDES
AB Watershed land-use changes, including urbanization, have caused accelerated soil erosion, which in turn has increased sediment accumulation rates in most aging reservoirs in the mid-western United States (USA), thereby posing a threat to their longevity and productivity. We analyzed three sediment cores from each of two reservoirs in the mid-western USA, the Webber Dam impoundment in Michigan and Goshen Pond in Indiana. Core chronologies were established using Cs-137 and Pb-210. Concentrations of organic carbon and nitrogen and their stable isotope compositions (delta C-13 and delta N-15) were measured to investigate past land-use changes. We used three excess Pb-210-based (Pb-210(xs)) sedimentation rate models (constant Pb-210 flux and sedimentation, constant rate of supply of Pb-210 and constant initial Pb-210 concentration) to develop core chronologies and compared them to the chronology obtained from the Cs-137 peak. Validation of the excess Pb-210-based chronology with(137)Cs-based chronology requires more than one Pb-210(xs)-based-model. That is, even in one watershed, output from more than one Pb-210(xs)-based model may have to be compared with an independent time marker. We compared C/N ratios, delta C-13 and delta N-15 among three time horizons in each of the three cores from the reservoirs (corresponding to dates of 1950, 1970 and 2010). Within a reservoir, there can be large differences between cores for a given time horizon, indicating there could be spatial differences in sources of C and N and the processes that influence carbon and nitrogen isotopes. We conclude that multiple sediment cores from reservoirs should be analyzed if carbon and nitrogen isotopes in sediments are to be used for paleoenvironmental inference.
C1 [Kumar, A.; Hage-Hassan, J.; Baskaran, M.] Wayne State Univ, Dept Geol, Detroit, MI 48202 USA.
[Miller, C. J.] Wayne State Univ, Dept Civil & Environm Engn, Detroit, MI 48202 USA.
[Selegean, J. P.; Creech, C. T.] US Army, Corps Engineers, Detroit, MI 48226 USA.
RP Baskaran, M (reprint author), Wayne State Univ, Dept Geol, Detroit, MI 48202 USA.
EM Baskaran@wayne.edu
FU U.S. Army Corps of Engineers [W911XK-10-C-0011, W911XK-14-C-0023]
FX We thank Robin Heichel for help with sample preparation for stable
isotope analysis. We thank John Barkach for assisting us with the
sediment core collection. This project was funded by the U.S. Army Corps
of Engineers (W911XK-10-C-0011 and W911XK-14-C-0023). We thank the two
anonymous reviewers for their in-depth review of our manuscript. We
thank Editor Mark Brenner for a thorough editing of the manuscript.
NR 39
TC 0
Z9 0
U1 9
U2 15
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0921-2728
EI 1573-0417
J9 J PALEOLIMNOL
JI J. Paleolimn.
PD JUN
PY 2016
VL 56
IS 1
BP 15
EP 31
DI 10.1007/s10933-016-9888-0
PG 17
WC Environmental Sciences; Geosciences, Multidisciplinary; Limnology
SC Environmental Sciences & Ecology; Geology; Marine & Freshwater Biology
GA DN2KX
UT WOS:000376893600002
ER
PT J
AU Kunces, LJ
Johnson, EC
Munoz, CX
Hydren, JR
Huggins, RA
Judelson, DA
Ganio, MS
Vingren, JL
Volek, JS
Armstrong, LE
AF Kunces, Laura J.
Johnson, Evan C.
Munoz, Colleen X.
Hydren, Jay R.
Huggins, Robert A.
Judelson, Daniel A.
Ganio, Mathew S.
Vingren, Jakob L.
Volek, Jeff S.
Armstrong, Lawrence E.
TI OBSERVED DIETARY PRACTICES OF RECREATIONAL ULTRAENDURANCE CYCLISTS IN
THE HEAT
SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
LA English
DT Article
DE athletes; nutrition; macronutrients; carbohydrates
ID SUBMAXIMAL EXERCISE; PERFORMANCE; OXIDATION; ENDURANCE
AB Dietary approaches for optimizing exercise performance have been debated in the literature for years. For endurance athletes, various position stands focus on recommendations for high-carbohydrate diets to maximize performance in events. However, theories of low-carbohydrate diets and their ability to provide more fuel may prove beneficial to ultraendurance athletes. Therefore, the purpose of this research was to observe the food and fluid consumption of successful recreational ultraendurance cyclists on the day before (ED-1), Event Day, and the day after (ED+1), a 162 km endurance event in a hot environment, and subsequently compare dietary intakes to recommendations and other observed dietary practices. Twenty men (age, 48 +/- 8 years; mass, 85.1 +/- 13.4 kg; height, 178.2 +/- 7.4 cm) recorded all dietary items during ED-1, Event Day, and ED+1. Diet composition and the relationships between carbohydrate and caloric intake with finish time were examined. Results show athletes consumed a high-carbohydrate diet on ED-1 (384 g.d(-1)), Event Day (657 g.d(-1)), and ED+1 (329 g.d(-1)). However, there were no significant associations between carbohydrate (p > 0.05), or caloric intake (p > 0.05), and finish time. This study results great variation in diets of recreational endurance cyclists, although most consume within nationally recognized dietary recommendation ranges. Because there is great variation and lack of correlation with performance, these findings suggest that current high-carbohydrate dietary recommendations for general endurance athletes may not be sport specific or individualized enough for recreational ultraendurance cyclists, and that individualized dietary macronutrient composition manipulations may improve performance outcomes.
C1 [Kunces, Laura J.] EXOS, Phoenix, AZ USA.
[Johnson, Evan C.] Univ Arkansas, Fayetteville, AR 72701 USA.
[Munoz, Colleen X.; Huggins, Robert A.; Armstrong, Lawrence E.] Univ Connecticut, Storrs, CT USA.
[Hydren, Jay R.] US Army, Environm Med Res Inst, Natick, MA 01760 USA.
[Judelson, Daniel A.] Calif State Univ Fullerton, Fullerton, CA 92634 USA.
[Vingren, Jakob L.] Univ N Texas, Denton, TX 76203 USA.
[Volek, Jeff S.] Ohio State Univ, Columbus, OH 43210 USA.
RP Kunces, LJ (reprint author), EXOS, Phoenix, AZ USA.
EM LKunces@gmail.com
NR 16
TC 0
Z9 0
U1 3
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1064-8011
EI 1533-4287
J9 J STRENGTH COND RES
JI J. Strength Cond. Res.
PD JUN
PY 2016
VL 30
IS 6
BP 1607
EP 1612
PG 6
WC Sport Sciences
SC Sport Sciences
GA DN5LC
UT WOS:000377107900015
PM 26492102
ER
PT J
AU Belmont, PJ
Owens, BD
Schoenfeld, AJ
AF Belmont, Philip J.
Owens, Brett D.
Schoenfeld, Andrew J.
TI Musculoskeletal Injuries in Iraq and Afghanistan: Epidemiology and
Outcomes Following a Decade of War
SO JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
LA English
DT Review
ID OPERATION ENDURING FREEDOM; BRIGADE COMBAT TEAM; SPINAL-INJURIES;
EXTREMITY WOUNDS; ARMY; POPULATION; CASUALTIES; DISEASE
AB The combined wars in Afghanistan and Iraq represent the longest ongoing conflicts in American military history, with a combined casualty estimate of >59,000 service members. The nature of combat over the last decade has led to precipitous increases in severe orthopaedic injuries, including traumatic amputations and injuries to the spine. Nearly 75% of all injuries sustained in combat now are caused by explosive mechanisms, and fractures comprise 40% of all musculoskeletal injuries. Injuries to the axial skeleton are more frequent among personnel exposed to combat, and spinal trauma is identified in nearly 40% of those killed. Musculoskeletal injuries are expensive and generate some of the highest rates of long-term disability. Noncombat musculoskeletal injuries are endemic within deployed military service members and occur at a greater than threefold rate compared with combat musculoskeletal injuries. Service members with musculoskeletal injuries or behavioral health conditions, such as posttraumatic stress disorder, depression, and psychosis, and those occupying a low socioeconomic status, have an increased risk of inferior outcomes.
C1 [Belmont, Philip J.] William Beaumont Army Med Ctr, Dept Orthoped Surg & Rehabil, El Paso, TX 79920 USA.
[Owens, Brett D.] Keller Army Community Hosp, Dept Orthoped, West Point, NY USA.
[Schoenfeld, Andrew J.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Orthopaed Surg, Boston, MA 02115 USA.
RP Belmont, PJ (reprint author), William Beaumont Army Med Ctr, Dept Orthoped Surg & Rehabil, El Paso, TX 79920 USA.
OI Schoenfeld, Andrew/0000-0002-3691-1215
NR 32
TC 0
Z9 0
U1 1
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1067-151X
EI 1940-5480
J9 J AM ACAD ORTHOP SUR
JI J. Am. Acad. Orthop. Surg.
PD JUN
PY 2016
VL 24
IS 6
BP 341
EP 348
DI 10.5435/JAAOS-D-15-00123
PG 8
WC Orthopedics; Surgery
SC Orthopedics; Surgery
GA DN1GH
UT WOS:000376813800002
PM 27115793
ER
PT J
AU Kucera, KL
Marshall, SW
Wolf, SH
Padua, DA
Cameron, KL
Beutler, AI
AF Kucera, Kristen L.
Marshall, Stephen W.
Wolf, Susanne H.
Padua, Darin A.
Cameron, Kenneth L.
Beutler, Anthony I.
TI Association of Injury History and Incident Injury in Cadet Basic
Military Training
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Article
DE EPIDEMIOLOGY; LOWER EXTREMITY; ANKLE; KNEE; RISK FACTORS
ID EXERCISE-RELATED INJURIES; FEMALE ARMY TRAINEES; RISK-FACTORS;
MUSCULOSKELETAL INJURIES; MEDICAL SURVEILLANCE; YOUTH SOCCER;
PREVENTION; SCHOOL; PROGRAM; SPORTS
AB Purpose This study aimed to determine the association between injury history at enrollment and incident lower extremity (LE) injury during cadet basic training among first-year military cadets.
Methods Medically treated LE injuries during cadet basic training documented in the Defense Medical Surveillance System were ascertained in a prospective cohort study of three large US military academies from 2005 to 2008. Both acute injuries (International Classification of Disease, Ninth Revision, codes in the 800-900s, including fracture, dislocations, and sprains/strains) and injury-related musculoskeletal injuries (International Classification of Disease, Ninth Revision, codes in the 700s, including inflammation and pain, joint derangement, stress fracture, sprain/strain/rupture, and dislocation) were included. Risk ratio (RR) and 95% confidence interval (CI) were computed using multivariate log-binomial models stratified by gender.
Results During basic training, there were 1438 medically treated acute and 1719 musculoskeletal-related LE injuries in the 9811 cadets. The most frequent LE injuries were sprains/strains (73.6% of acute injuries) and inflammation and pain (89.6% of musculoskeletal-related injuries). The overall risk of incident LE injury was 23.2% (95% CI = 22.3%-24.0%). Cadets with a history of LE injury were at increased risk for incident LE injury. This association was identical in males (RR = 1.74, 95% CI = 1.55-1.94) and females (RR = 1.74, 95% CI = 1.52-1.99). In site-specific analyses, strong associations between injury history and incident injury were observed for hip, knee ligament, stress fracture, and ankle sprain. Injury risk was greater (P < 0.01) for females (39.1%) compared with males (18.0%). The elevated injury risk in females (RR = 2.19, 95% CI = 2.04-2.36) was independent of injury history (adjusted RR = 2.09, 95% CI = 1.95-2.24).
Conclusion Injury history upon entry to the military is associated with the incidence of LE injuries sustained during cadet basic training. Prevention programs targeted at modifiable factors in cadets with a history of LE injury should be considered.
C1 [Kucera, Kristen L.; Padua, Darin A.] Univ N Carolina, Dept Exercise & Sports Sci, 209 Fetzer Hall, Chapel Hill, NC 27599 USA.
[Marshall, Stephen W.; Wolf, Susanne H.] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA.
[Padua, Darin A.] Univ N Carolina, Sports Med Res Lab, Chapel Hill, NC USA.
[Cameron, Kenneth L.] US Mil Acad, Keller Army Hosp, John Feagin Jr Sports Med Fellowship, West Point, NY USA.
[Beutler, Anthony I.] Uniformed Serv Univ Hlth Sci, Dept Family Med, Bethesda, MD 20814 USA.
RP Kucera, KL (reprint author), Univ N Carolina, Dept Exercise & Sports Sci, 209 Fetzer Hall, Chapel Hill, NC 27599 USA.
EM kkucera@email.unc.edu
OI Cameron, Kenneth/0000-0002-6276-4482
FU National Institute of Arthritis and Musculoskeletal and Skin Diseases,
National Institutes of Health [R01-AR054061001]; American Orthopedic
Society for Sports Medicine; National Center for Injury Prevention and
Control, Centers for Disease Control and Prevention [R49/CE002479]
FX The JUMP-ACL study was funded by the National Institute of Arthritis and
Musculoskeletal and Skin Diseases, National Institutes of Health
(R01-AR054061001). Pilot work was supported by the American Orthopedic
Society for Sports Medicine. Dr. Stephen W. Marshall and the University
of North Carolina Injury Prevention Research Center are partially
supported by an award from the National Center for Injury Prevention and
Control, Centers for Disease Control and Prevention (R49/CE002479). The
views and opinions expressed are those of the authors and do not reflect
the official policy of the US Service Academies, the Department of
Defense, or the US Government. Special thanks to all the cadets who
participated in this study and to service academies that supported the
study. We would also like to acknowledge the members of the JUMP-ACL
study team. From the UNC-CH: Shrikant Bangdiwala, Ph.D.; Bing Yu, Ph.D.;
Michelle Boling, Ph.D., A.T.C.; Chuck Thigpen, Ph.D., P.T., A.T.C.;
Lindsay Strickland, Ph.D., A.T.C.; Ben Goeger, Ph.D., A.T.C.; Candice
Goerger, M.S., A.T.C.; Melanie McGrath, Ph.D., A.T.C.; David Bell,
M.Ed., Ph.D., A.T.C.; and Kevin Guskiewicz, Ph.D., A.T.C. From other
universities: William E. Garrett Ph.D., M.D. (Duke University); COL(Ret)
Dean Taylor, M.D. (Duke University); Julie Gilchrist, M.D. (Centers for
Disease Control and Prevention); and James Onate Ph.D., A.T.C. (Old
Dominion University). From the USNA: CDR Scott Pyne, M.D.; CDR David
Keblish, M.D.; CDR Sean Kelly, M.D.; and Gregg Calhoon, A.T.C. From the
USAFA: COL John Tokish, M.D.; Barbara Coley; and COL Robert Sullivan,
M.D. From the USMA: Karen Y. Peck, M.Ed., A.T.C.; COL (Ret) Thomas M.
DeBerardino, M.D.; Sally B. Mountcastle, Ph.D.; COL (Ret) Paul D.
Stoneman, P.T., Ph.D.; COL Steven J. Svoboda, M.D.; and LTC(P) Brett D.
Owens, M.D.
NR 31
TC 0
Z9 0
U1 1
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD JUN
PY 2016
VL 48
IS 6
BP 1053
EP 1061
DI 10.1249/MSS.0000000000000872
PG 9
WC Sport Sciences
SC Sport Sciences
GA DM8MO
UT WOS:000376617900010
PM 26765627
ER
PT J
AU Ishizuka, AS
Lyke, KE
DeZure, A
Berry, AA
Richie, TL
Mendoza, FH
Enama, ME
Gordon, IJ
Chang, LJ
Sarwar, UN
Zephir, KL
Holman, LA
James, ER
Billingsley, PF
Gunasekera, A
Chakravarty, S
Manoj, A
Li, ML
Ruben, AJ
Li, T
Eappen, AG
Stafford, RE
Natasha, KC
Murshedkar, T
DeCederfelt, H
Plummer, SH
Hendel, CS
Novik, L
Costner, PJM
Saunders, JG
Laurens, MB
Plowe, CV
Flynn, B
Whalen, WR
Todd, JP
Noor, J
Rao, S
Sierra-Davidson, K
Lynn, GM
Epstein, JE
Kemp, MA
Fahle, GA
Mikolajczak, SA
Fishbaugher, M
Sack, BK
Kappe, SHI
Davidson, SA
Garver, LS
Bjorkstrom, NK
Nason, MC
Graham, BS
Roederer, M
Sim, BKL
Hoffman, SL
Ledgerwood, JE
Seder, RA
AF Ishizuka, Andrew S.
Lyke, Kirsten E.
DeZure, Adam
Berry, Andrea A.
Richie, Thomas L.
Mendoza, Floreliz H.
Enama, Mary E.
Gordon, Ingelise J.
Chang, Lee-Jah
Sarwar, Uzma N.
Zephir, Kathryn L.
Holman, LaSonji A.
James, Eric R.
Billingsley, Peter F.
Gunasekera, Anusha
Chakravarty, Sumana
Manoj, Anita
Li, MingLin
Ruben, Adam J.
Li, Tao
Eappen, Abraham G.
Stafford, Richard E.
Natasha, K. C.
Murshedkar, Tooba
DeCederfelt, Hope
Plummer, Sarah H.
Hendel, Cynthia S.
Novik, Laura
Costner, Pamela J. M.
Saunders, Jamie G.
Laurens, Matthew B.
Plowe, Christopher V.
Flynn, Barbara
Whalen, William R.
Todd, J. P.
Noor, Jay
Rao, Srinivas
Sierra-Davidson, Kailan
Lynn, Geoffrey M.
Epstein, Judith E.
Kemp, Margaret A.
Fahle, Gary A.
Mikolajczak, Sebastian A.
Fishbaugher, Matthew
Sack, Brandon K.
Kappe, Stefan H. I.
Davidson, Silas A.
Garver, Lindsey S.
Bjorkstrom, Niklas K.
Nason, Martha C.
Graham, Barney S.
Roederer, Mario
Sim, B. Kim Lee
Hoffman, Stephen L.
Ledgerwood, Julie E.
Seder, Robert A.
CA VRC 312& VRC Study Teams
TI Protection against malaria at 1 year and immune correlates following
PfSPZ vaccination
SO NATURE MEDICINE
LA English
DT Article
ID DELTA-T-CELLS; NONREPLICATING SPOROZOITE VACCINE; PLASMODIUM-FALCIPARUM;
MONOCLONAL-ANTIBODIES; LIVER STAGES; IMMUNIZATION; MICE; EFFICACY;
BERGHEI; MEMORY
AB An attenuated Plasmodium falciparum (Pf) sporozoite (SPZ) vaccine, PfSPZ Vaccine, is highly protective against controlled human malaria infection (CHMI) 3 weeks after immunization, but the durability of protection is unknown. We assessed how vaccine dosage, regimen, and route of administration affected durable protection in malaria-naive adults. After four intravenous immunizations with 2.7 x 10(5) PfSPZ, 6/11 (55%) vaccinated subjects remained without parasitemia following CHMI 21 weeks after immunization. Five non-parasitemic subjects from this dosage group underwent repeat CHMI at 59 weeks, and none developed parasitemia. Although Pf-specific serum antibody levels correlated with protection up to 21-25 weeks after immunization, antibody levels waned substantially by 59 weeks. Pf-specific T cell responses also declined in blood by 59 weeks. To determine whether T cell responses in blood reflected responses in liver, we vaccinated nonhuman primates with PfSPZ Vaccine. Pf-specific interferon-g-producing CD8 T cells were present at similar to 100-fold higher frequencies in liver than in blood. Our findings suggest that PfSPZ Vaccine conferred durable protection to malaria through long-lived tissue-resident T cells and that administration of higher doses may further enhance protection.
C1 [Ishizuka, Andrew S.; DeZure, Adam; Mendoza, Floreliz H.; Enama, Mary E.; Gordon, Ingelise J.; Chang, Lee-Jah; Sarwar, Uzma N.; Zephir, Kathryn L.; Holman, LaSonji A.; Plummer, Sarah H.; Hendel, Cynthia S.; Novik, Laura; Costner, Pamela J. M.; Saunders, Jamie G.; Flynn, Barbara; Whalen, William R.; Todd, J. P.; Noor, Jay; Rao, Srinivas; Sierra-Davidson, Kailan; Lynn, Geoffrey M.; Graham, Barney S.; Roederer, Mario; Ledgerwood, Julie E.; Seder, Robert A.] NIAID, VRC, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
[Lyke, Kirsten E.; Berry, Andrea A.; Laurens, Matthew B.; Plowe, Christopher V.] Univ Maryland, Sch Med, Inst Global Hlth, Ctr Vaccine Dev, Baltimore, MD 21201 USA.
[Lyke, Kirsten E.; Berry, Andrea A.; Laurens, Matthew B.; Plowe, Christopher V.] Univ Maryland, Sch Med, Div Malaria Res, Baltimore, MD 21201 USA.
[Richie, Thomas L.; James, Eric R.; Billingsley, Peter F.; Gunasekera, Anusha; Chakravarty, Sumana; Manoj, Anita; Li, MingLin; Ruben, Adam J.; Li, Tao; Eappen, Abraham G.; Stafford, Richard E.; Natasha, K. C.; Murshedkar, Tooba; Sim, B. Kim Lee; Hoffman, Stephen L.] Sanaria Inc, Rockville, MD USA.
[Li, MingLin; Stafford, Richard E.; Natasha, K. C.; Sim, B. Kim Lee] Prot Potential LLC, Rockville, MD USA.
[DeCederfelt, Hope] NIH, Ctr Clin, Pharmaceut Dev Sect, Bethesda, MD 20892 USA.
[Epstein, Judith E.] NMRC, Malaria Dept, Silver Spring, MD USA.
[Kemp, Margaret A.; Fahle, Gary A.] NIH, Ctr Clin, Dept Lab Med, Bethesda, MD 20892 USA.
[Mikolajczak, Sebastian A.; Fishbaugher, Matthew; Sack, Brandon K.; Kappe, Stefan H. I.] Ctr Infect Dis Res, Seattle, WA USA.
[Davidson, Silas A.; Garver, Lindsey S.] Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD USA.
[Bjorkstrom, Niklas K.] Karolinska Inst, Karolinska Univ Hosp, Dept Med Huddinge, Ctr Infect Med, Stockholm, Sweden.
[Nason, Martha C.] NIAID, Biostat Res Branch, Div Clin Res, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
[Chang, Lee-Jah] Sanofi, Swiftwater, PA USA.
[Sarwar, Uzma N.] Montefiore Med Ctr, Albert Einstein Coll Med, New York, NY USA.
[Rao, Srinivas] Sanofi, Cambridge, MA USA.
RP Seder, RA (reprint author), NIAID, VRC, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
EM rseder@mail.nih.gov
RI Laurens, Matthew/E-7293-2013;
OI Laurens, Matthew/0000-0003-3874-581X; Ishizuka,
Andrew/0000-0002-3024-7536; Bjorkstrom, Niklas/0000-0002-0967-076X;
Mikolajczak, Sebastian/0000-0003-1996-9703
FU VRC, NIAID, NIH; NIAID [5R44AI055229-11, 5R44AI058499-08,
5R44AI058375-08]; Bill and Melinda Gates Foundation [24922];
[6000.RADI.F.A0309]
FX The authors thank the vaccine trials participants for their contribution
and commitment to vaccine research. We acknowledge the contributions of:
our US National Institutes of Health (NIH) Clinical Center (CC) and
National Institute of Allergy and Infectious Diseases (NIAID)
colleagues, especially J. Stein, J. Pierson, R. Eckes, P. Driscoll, L.
Ediger, and the nursing staff of the 5NW, SCSU, 5SE-S, and 5SE-N units;
our VRC colleagues, especially A. Mittelman, H. Harvey, M. Young, C.
Artis, R. Hicks, P. Darrah, and T. Abram; our Sanaria and Protein
Potential colleagues, especially Y. Abebe, J. Jackson, A. Awe, M. King,
H. Huang, A. Patil, S. Matheny, J. Overby, Y. Wen, K. Nelson, V. Pich,
M. Orozco, D. Padilla, E. Saverino, B. Jiang, L. Gao, R. Xu, E.
Fomumbod, M. Laskowski, T. T. Wai, F. Beams, R. Thompson, and A. Hoffman
for administrative, operations, and legal support, and T. Luke for
insight and inspiration; the EMMES Corporation; the NIAID Institutional
Review Board; the NIAID Office of Communications and Government
Relations; the NIH CC Department of Laboratory Medicine; the NIH CC IND
Pharmacy, and the NIH CC Patient Recruitment and Public Liaison Office.
We appreciate the expert reviews of the Safety Monitoring Committee (A.
Durbin, K. Kester, and A. Cross) and the assistance from the US Military
Malaria Vaccine Program, the Walter Reed Army Institute of Research
Entomology Branch, and the Naval Medical Research Center (NMRC),
especially A. Reyes, Y. Alcorta, G. Banania, C. Fedders, M. Dowler, T.
Savransky, D. Patel, C. Brando, K. Kobylinski, and K. Walker. This work
was supported by the intramural research program of the VRC, NIAID, NIH.
Production and characterization of the PfSPZ Vaccine were supported in
part by NIAID Small Business Innovation Research grants 5R44AI055229-11
(S. L. H.), 5R44AI058499-08 (S. L. H.), and 5R44AI058375-08 (S. L. H.).
The humanized mouse experiments reported here were funded by the Bill
and Melinda Gates Foundation (Investment ID: 24922; to S. H. I. K.). The
findings and conclusions in this report are those of the authors and do
not necessarily reflect the views of the funding agency or
collaborators. The views expressed in this article are those of the
author and do not necessarily reflect the official policy or position of
the Department of the Navy, the Department of the Army, the Department
of Defense, or the US Government. This work was supported in part by
work unit number 6000.RADI.F.A0309 to NMRC. J. E. E. and S. A. D. are
military service members, and this work was prepared as part of their
official duties. Title 17 U.S.C. $101 defines a US Government work as a
work prepared by a military service member or employee of the US
Government as part of that person's official duties.
NR 49
TC 15
Z9 15
U1 5
U2 8
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1078-8956
EI 1546-170X
J9 NAT MED
JI Nat. Med.
PD JUN
PY 2016
VL 22
IS 6
BP 614
EP +
DI 10.1038/nm.4110
PG 13
WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research &
Experimental
SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental
Medicine
GA DO0NQ
UT WOS:000377476000014
PM 27158907
ER
PT J
AU Menger, RP
Wolf, ME
Lang, RW
Smith, DR
Nanda, A
Letarte, P
Rosner, MK
AF Menger, Richard P.
Wolf, Michael E.
Lang, Richard W.
Smith, Donald R.
Nanda, Anil
Letarte, Peter
Rosner, Michael K.
TI Military Neurosurgery: A Range of Service Options
SO NEUROSURGERY
LA English
DT Article
DE Military neurosurgery; Military service; Socioeconomic analysis; United
States Air Force; United States Army; United States Navy
ID EXPERIENCE
AB The pathway to military neurosurgical practice can include a number of accession options. This article is an objective comparison of fiscal, tangible, and intangible benefits provided through different military neurosurgery career paths. Neurosurgeons may train through active duty, reserve, or civilian pathways. These modalities were evaluated on the basis of economic data during residency and the initial 3 years afterwards. When available, military base pay, basic allowance for housing and subsistence, variable special pay, board certified pay, incentive pay, multiyear special pay, reserve drill pay, civilian salary, income tax, and other tax incentives were analyzed using publically available data. Civilians had lower residency pay, higher starting salaries, increased taxes, malpractice insurance cost, and increased overhead. Active duty service saw higher residency pay, lower starting salary, tax incentives, increased benefits, and almost no associated overhead including malpractice coverage. Reserve service saw a combination of civilian benefits with supplementation of reserve drill pay in return for weekend drill and the possibility of deployment and activation. Being a neurosurgeon in the military is extremely rewarding. From a financial perspective, ignoring intangibles, this article shows most entry pathways with initially modest differences between the cumulative salaries of active duty and civilian career paths and with higher overall compensation available from the reserve service option. These pathways become increasingly discrepant over time as civilian pay greatly exceeds that of military neurosurgeons. We hope that those curious about or considering serving in the United States military benefit from our accounting and review of these comparative paths.ABBREVIATIONS:FAP, Financial Assistance ProgramNADDS, Navy Active Duty Delay for SpecialistsTMS, Training in Medical Specialties
C1 [Menger, Richard P.; Smith, Donald R.; Nanda, Anil] Louisiana State Univ Hlth Sci, Dept Neurosurg, Shreveport, LA USA.
[Wolf, Michael E.] Air Test & Evaluat Squadron Three Zero, Dept Aerosp Med, Point Mugu Nawc, CA USA.
[Menger, Richard P.; Wolf, Michael E.; Lang, Richard W.; Letarte, Peter] US Navy, Philadelphia, PA USA.
[Smith, Donald R.] US Air Force, Boulder, CO USA.
[Letarte, Peter] Loyola Univ, Med Ctr, Dept Neurol Surg, 2160 S 1st Ave, Maywood, IL 60153 USA.
[Rosner, Michael K.] Walter Reed Natl Mil Med Ctr, Neurosurg Serv, Bethesda, MD USA.
[Rosner, Michael K.] US Army, Boulder, CO USA.
RP Menger, RP (reprint author), 1501 Kings Highway, Shreveport, LA 71103 USA.
EM richard.menger@gmail.com
NR 12
TC 0
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U1 1
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-396X
J9 NEUROSURGERY
JI Neurosurgery
PD JUN
PY 2016
VL 78
IS 6
BP 765
EP 773
DI 10.1227/NEU.0000000000001084
PG 9
WC Clinical Neurology; Surgery
SC Neurosciences & Neurology; Surgery
GA DN2GO
UT WOS:000376882300016
PM 26528672
ER
PT J
AU Scerbo, MH
Kaplan, HB
Dua, A
Litwin, DB
Ambrose, CG
Moore, LJ
Murray, CK
Wade, CE
Holcomb, JB
AF Scerbo, Michelle H.
Kaplan, Heidi B.
Dua, Anahita
Litwin, Douglas B.
Ambrose, Catherine G.
Moore, Laura J.
Murray, Clinton K.
Wade, Charles E.
Holcomb, John B.
TI Beyond Blood Culture and Gram Stain Analysis: A Review of Molecular
Techniques for the Early Detection of Bacteremia in Surgical Patients
SO SURGICAL INFECTIONS
LA English
DT Review
ID REAL-TIME PCR; INADEQUATE ANTIMICROBIAL TREATMENT; PERFORMANCE
IMPROVEMENT PROGRAM; POLYMERASE-CHAIN-REACTION; FLIGHT
MASS-SPECTROMETRY; CRITICALLY-ILL PATIENTS; INTENSIVE-CARE UNITS; HUMAN
SEPTIC SHOCK; STREAM INFECTIONS; SEVERE SEPSIS
AB Background: Sepsis from bacteremia occurs in 250,000 cases annually in the United States, has a mortality rate as high as 60%, and is associated with a poorer prognosis than localized infection. Because of these high figures, empiric antibiotic administration for patients with systemic inflammatory response syndrome (SIRS) and suspected infection is the second most common indication for antibiotic administration in intensive care units (ICU)s. However, overuse of empiric antibiotics contributes to the development of opportunistic infections, antibiotic resistance, and the increase in multi-drug-resistant bacterial strains. The current method of diagnosing and ruling out bacteremia is via blood culture (BC) and Gram stain (GS) analysis.
Methods: Conventional and molecular methods for diagnosing bacteremia were reviewed and compared. The clinical implications, use, and current clinical trials of polymerase chain reaction (PCR)-based methods to detect bacterial pathogens in the blood stream were detailed.
Results: BC/GS has several disadvantages. These include: some bacteria do not grow in culture media; others do not GS appropriately; and cultures can require up to 5 d to guide or discontinue antibiotic treatment. PCR-based methods can be potentially applied to detect rapidly, accurately, and directly microbes in human blood samples.
Conclusions: Compared with the conventional BC/GS, particular advantages to molecular methods (specifically, PCR-based methods) include faster results, leading to possible improved antibiotic stewardship when bacteremia is not present.
C1 [Scerbo, Michelle H.; Moore, Laura J.; Wade, Charles E.; Holcomb, John B.] Univ Texas Hlth Sci Ctr Houston, Dept Surg, Ctr Translat Injury Res CeTIR, Houston, TX 77030 USA.
[Kaplan, Heidi B.; Litwin, Douglas B.] Univ Texas Hlth Sci Ctr Houston, Dept Microbiol & Mol Genet, Houston, TX 77030 USA.
[Ambrose, Catherine G.] Univ Texas Hlth Sci Ctr Houston, Dept Orthoped Surg, Houston, TX 77030 USA.
[Dua, Anahita] Med Coll Wisconsin, Dept Surg, 8700 W Wisconsin Ave, Milwaukee, WI 53226 USA.
[Murray, Clinton K.] Brooke Army Med Ctr, Dept Med, Infect Dis Serv, Ft Sam Houston, TX 78234 USA.
RP Scerbo, MH (reprint author), Univ Texas Hlth Sci Ctr Houston, Dept Surg, UTP 1100-26 6410 Fannin St, Houston, TX 77030 USA.
EM Michelle.l.scerbo@uth.tmc.edu
FU NIGMS NIH HHS [T32 GM008792]
NR 85
TC 1
Z9 1
U1 1
U2 4
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD JUN
PY 2016
VL 17
IS 3
BP 294
EP 302
DI 10.1089/sur.2015.099
PG 9
WC Infectious Diseases; Surgery
SC Infectious Diseases; Surgery
GA DN5MQ
UT WOS:000377113200004
PM 26918696
ER
PT J
AU Hruby, A
Bulathsinhala, L
McKinnon, CJ
Hill, OT
Montain, SJ
Young, AJ
Smith, TJ
AF Hruby, Adela
Bulathsinhala, Lakmini
McKinnon, Craig J.
Hill, Owen T.
Montain, Scott J.
Young, Andrew J.
Smith, Tracey J.
TI BMI and Lower Extremity Injury in US Army Soldiers, 2001-2011
SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE
LA English
DT Article
ID RISK-FACTORS; MUSCULOSKELETAL INJURIES; PHYSICAL-FITNESS; UNITED-STATES;
RECRUITS; OBESITY; OVERWEIGHT; INFANTRY
AB Introduction: Little data exist regarding the long-term impact of excess weight on lower extremity musculoskeletal injury/disorder (MID) in U.S. Army Soldiers. This prospective analysis examines the association between BMI of Soldiers at accession and risk of MID.
Methods: A total of 736,608 Soldiers were followed from accession into the Army, 2001-2011. Data were analyzed January through March 2015. MID was categorized as any first incident lower extremity musculoskeletal injury/disorder, and secondarily, as first incident injury/disorder at a specific site (i.e., hips, upper legs/thighs, knees, lower legs/ankles, feet/toes). Multivariable-adjusted proportional hazards models estimated associations between BMI category at accession and MID risk.
Results: During 15,678,743 person-months of follow-up, 411,413 cases of any first MID were documented (70,578 hip, 77,050 upper leg, 162,041 knee, 338,080 lower leg, and 100,935 foot injuries in secondary analyses). The overall MID rate was 2.62 per 100 person-months. Relative to Soldiers with normal BMI (18.5 to <25 kg/m(2)) at accession, those who were underweight (<18.5); overweight (25 to <30); or obese (>= 30) had 7%, 11%, and 33% higher risk of MID, respectively, after adjustment. Risks were highest in Soldiers who were obese at accession, and lowest in those with a BMI of 21-23 kg/m(2).
Conclusions: Soldier BMI at accession has important implications for MID. A BMI of 21-23 kg/m(2) in newly accessing Soldiers was associated with the lowest risk of incident MID, suggesting that accession be limited to people within this range to reduce overall incidence of MID among service personnel. Published by Elsevier Inc. on behalf of American Journal of Preventive Medicine
C1 [Hruby, Adela; Montain, Scott J.; Young, Andrew J.; Smith, Tracey J.] US Army Res Inst Environm Med, Mil Nutr Div, 15 Gen Greene Ave,Bldg 42, Natick, MA 01760 USA.
[Hruby, Adela] Harvard Univ, Dept Nutr, TH Chan Sch Publ Hlth, Boston, MA 02115 USA.
[Bulathsinhala, Lakmini; McKinnon, Craig J.; Hill, Owen T.] US Army Res Inst Environm Med, Environm Med Mil Performance Div, Natick, MA 01760 USA.
[Bulathsinhala, Lakmini; Hill, Owen T.] Ctr Intrepid, Houston, TX USA.
RP Smith, TJ (reprint author), US Army Res Inst Environm Med, Mil Nutr Div, 15 Gen Greene Ave,Bldg 42, Natick, MA 01760 USA.
EM tracey.smith10.civ@mail.mil
NR 31
TC 1
Z9 1
U1 2
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0749-3797
EI 1873-2607
J9 AM J PREV MED
JI Am. J. Prev. Med.
PD JUN
PY 2016
VL 50
IS 6
BP E163
EP E171
DI 10.1016/j.amepre.2015.10.015
PG 9
WC Public, Environmental & Occupational Health; Medicine, General &
Internal
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA DM7CD
UT WOS:000376509900001
PM 26699247
ER
PT J
AU Dimitrova, R
Silver, Z
Zsedrovits, T
Hocut, CM
Leo, LS
Di Sabatino, S
Fernando, HJS
AF Dimitrova, Reneta
Silver, Zachariah
Zsedrovits, Tamas
Hocut, Christopher M.
Leo, Laura S.
Di Sabatino, Silvana
Fernando, Harindra J. S.
TI Assessment of Planetary Boundary-Layer Schemes in the Weather Research
and Forecasting Mesoscale Model Using MATERHORN Field Data
SO BOUNDARY-LAYER METEOROLOGY
LA English
DT Article
DE Boundary-layer parametrization; Complex terrain; Stable boundary layer;
Turbulence; Weather Research and Forecasting model evaluation
ID ATMOSPHERIC SURFACE-LAYER; NONLOCAL CLOSURE-MODEL; WRF MODEL; VERTICAL
DIFFUSION; NUMERICAL-SIMULATION; SIMILARITY THEORY; PBL SCHEMES; PART I;
SENSITIVITY; TURBULENCE
AB The study was aimed at understanding the deficiencies of numerical mesoscale models by comparing predictions with a new high-resolution meteorological dataset collected during the Mountain Terrain Atmospheric Modelling and Observations (MATERHORN) Program. The simulations focussed on the stable boundary layer (SBL), the predictions of which continue to be challenging. High resolution numerical simulations (0.5-km horizontal grid size) were conducted to investigate the efficacy of six planetary boundary-layer (PBL) parametrizations available in the advanced research version of the Weather Research and Forecasting model. One of the commonly used PBL schemes was modified to include eddy diffusivities that account for enhanced momentum transport compared to heat transport in the SBL, representing internal wave dynamics. All of the tested PBL schemes, including the modified scheme, showed a positive surface temperature bias. None of the PBL schemes was found to be superior in predicting the vertical wind and temperature profiles over the lowest 500 m, however two of the schemes appeared superior in capturing the lower PBL structure. The lowest model layers appear to have a significant impact on the predictions aloft. Regions of sporadic flow interactions delineated by the MATERHORN observations were poorly predicted, given such interactions are not represented in typical PBL schemes.
C1 [Dimitrova, Reneta; Silver, Zachariah; Zsedrovits, Tamas; Hocut, Christopher M.; Leo, Laura S.; Di Sabatino, Silvana; Fernando, Harindra J. S.] Univ Notre Dame, Civil & Environm Engn & Earth Sci, Notre Dame, IN 46556 USA.
[Dimitrova, Reneta] Bulgarian Acad Sci, Dept Geophys, Natl Inst Geophys Geodesy & Geog, Atmospher Phys, BU-1113 Sofia, Bulgaria.
[Zsedrovits, Tamas] Pazmany Peter Catholic Univ, Fac Informat Technol & Bion, H-1088 Budapest, Hungary.
[Hocut, Christopher M.] US Army, Res Lab, White Sands Missile Range, NM 88022 USA.
[Di Sabatino, Silvana] Univ Bologna, Dept Phys & Astron, Bologna, Italy.
RP Dimitrova, R (reprint author), Univ Notre Dame, Civil & Environm Engn & Earth Sci, Notre Dame, IN 46556 USA.; Dimitrova, R (reprint author), Bulgarian Acad Sci, Dept Geophys, Natl Inst Geophys Geodesy & Geog, Atmospher Phys, BU-1113 Sofia, Bulgaria.
EM Reneta.Dimitrova@nd.edu
RI Leo, Laura/J-9529-2013; Zsedrovits, Tamas/D-1362-2016
OI Leo, Laura/0000-0003-4103-6862; Zsedrovits, Tamas/0000-0003-0768-1171
FU US Office of Naval Research Award, Mountain Terrain Atmospheric
Modelling and Observations (MATERHORN) Program [N00014-11-1-0709];
European Union; State of Hungary [TAMOP-4.2.1.B-11/2/KMR-2011-0002]
FX This research was funded by the US Office of Naval Research Award #
N00014-11-1-0709, Mountain Terrain Atmospheric Modelling and
Observations (MATERHORN) Program. It has also been supported by the
European Union and the State of Hungary in the framework of
TAMOP-4.2.1.B-11/2/KMR-2011-0002 Instrument. Additional support was
provided by the University of Notre Dame's Centre for Research Computing
through computational and storage resources (we specifically acknowledge
the assistance of Dodi Heryadi). Furthermore, we are thankful to Jeffrey
Massey from the University of Utah for the updated land-cover and soil
data.
NR 80
TC 1
Z9 1
U1 1
U2 4
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0006-8314
EI 1573-1472
J9 BOUND-LAY METEOROL
JI Bound.-Layer Meteor.
PD JUN
PY 2016
VL 159
IS 3
BP 589
EP 609
DI 10.1007/s10546-015-0095-8
PG 21
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA DM5TG
UT WOS:000376412400007
ER
PT J
AU Jackson, KL
Devine, JG
AF Jackson, Keith L., II
Devine, John G.
TI The Effects of Obesity on Spine Surgery: A Systematic Review of the
Literature
SO GLOBAL SPINE JOURNAL
LA English
DT Article
DE obesity; surgical site infection; lumbar spine; venous thromboembolism
ID OUTCOMES-RESEARCH-TRIAL; BODY-MASS INDEX; LOW-BACK-PAIN; INTERVERTEBRAL
DISC DEGENERATION; LUMBAR SPINE; RISK-FACTOR; COMPLICATION RATES;
HOSPITAL COSTS; TERM OUTCOMES; FUSION
AB Study Design Literature review.
Objective The aim of this literature review is to examine the effects of obesity on postoperative complications and functional outcomes after spine surgery.
Methods A review of the relevant literature examining the effects of obesity and spine surgery was conducted using PubMed, Google Scholar, and Cochrane databases.
Results Obesity contributes to disk degeneration and low back pain and potentially increases the risk of developing operative pathology. Obese patients undergoing spine surgery have a higher risk of developing postoperative complications, particularly surgical site infection and venous thromboembolism. Though functional outcomes in this population may not mirror the general population, the treatment effect associated with surgery is at least equivalent if not better in obese individuals. This reduction is primarily due to worse outcomes associated with nonoperative treatment in the obese population.
Conclusion Obese individuals represent a unique patient population with respect to nonoperative treatment, postoperative complication rates, and functional outcomes. However, given the equivalent or greater treatment effect of surgery, this comorbidity should not prohibit obese patients from undergoing operative intervention. Future investigations in this area should attempt to develop strategies to minimize complications and improve outcomes in obese individuals and also examine the role of controlled weight loss preoperatively to mitigate these risks.
C1 [Jackson, Keith L., II] Womack Army Med Ctr, Dept Orthopaed & Rehabil, 2817 Reilly Rd, Ft Bragg, NC 28310 USA.
[Devine, John G.] Georgia Regents Univ, Dept Orthopaed Surg, Augusta, GA USA.
RP Jackson, KL (reprint author), Womack Army Med Ctr, Dept Orthopaed & Rehabil, 2817 Reilly Rd, Ft Bragg, NC 28310 USA.
EM Lynn.Jackson9@gmail.com
NR 55
TC 0
Z9 0
U1 1
U2 1
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 2192-5682
EI 2192-5690
J9 GLOB SPINE J
JI Glob. Spine J.
PD JUN
PY 2016
VL 6
IS 4
BP 394
EP 400
DI 10.1055/s-0035-1570750
PG 7
WC Orthopedics
SC Orthopedics
GA DM8JW
UT WOS:000376609600014
PM 27190743
ER
PT J
AU Lesho, E
Chukwuma, U
Sparks, M
Neumann, C
Richesson, D
Clifford, R
Gierhart, S
Waterman, P
Hinkle, M
AF Lesho, Emil
Chukwuma, Uzo
Sparks, Michael
Neumann, Charlotte
Richesson, Douglas
Clifford, Robert
Gierhart, Sarah
Waterman, Paige
Hinkle, Mary
TI Anatomic, Geographic, and Taxon-Specific Relative Risks of Carbapenem
Resistance in the Health Care System of the US Department of Defense
SO JOURNAL OF CLINICAL MICROBIOLOGY
LA English
DT Article
ID ENTEROBACTERIACEAE; INFECTIONS; USAGE; ACINETOBACTER; PATHOGENS;
CARRIAGE; PROGRAM
AB Carbapenem-resistant Pseudomonas aeruginosa, Acinetobacter spp., and Enterobacteriaceae pose urgent public health threats. The differential burden, relative risks, associations with antimicrobial consumption, and temporal trends of those taxa in large, geographically diverse U.S. health systems remain under reported. Electronic records of all patients in a geographically dispersed 280-hospital managed-care system from 2005 to 2014 were reviewed. Carbapenem-resistant strains were identified based on Clinical and Laboratory Standards Institute guidelines and breakpoints. A total of 360,000 potentially carbapenem-resistant strains were identified from 14.7 million cultures (80% infecting and 20% surveillance). Isolation of bacteria overseas or isolation from the bloodstream was associated with a higher relative risks of carbapenem resistance (CR; P < 0.0001). Enterobacteriaceae were isolated 11 times more frequently than P. aeruginosa and Acinetobacter spp. However, compared to Enterobacteriaceae, the CR levels were 73-fold and 210-fold higher in P. aeruginosa and Acinetobacter spp., respectively. Significant differences in the relative risk of CR between taxa, anatomic, and geographic locations persisted after adjustment for other variables, the biggest differences occurring between taxa. Overall, CR rates increased for Enterobacteriaceae (P = 0.03) and decreased for Acinetobacter spp. and P. aeruginosa (P < 0.0001). These data provide a useful baseline for resistance trending and have implications for surveillance. Infections acquired overseas and bloodstream infections are particularly important areas for continued monitoring.
C1 [Lesho, Emil; Sparks, Michael; Clifford, Robert; Hinkle, Mary] Walter Reed Army Inst Res, Antibiot Resistance Monitoring & Res Program, Silver Spring, MD USA.
[Chukwuma, Uzo; Neumann, Charlotte; Gierhart, Sarah] Navy & Marine Corps Public Hlth Ctr, EpiData Ctr Dept, Antibiot Resistance Monitoring & Res Program, Portsmouth, VA USA.
[Richesson, Douglas] Landstuhl Reg Med Ctr, Antibiot Resistance Monitoring & Res Program, Landstuhl, Germany.
[Waterman, Paige] Armed Forces Hlth Surveillance Branch, Global Emerging Infect Surveillance Sect, Silver Spring, MD USA.
RP Lesho, E (reprint author), Walter Reed Army Inst Res, Antibiot Resistance Monitoring & Res Program, Silver Spring, MD USA.
EM emil.p.lesho.mil@mail.mil
FU U.S. Army Medical Command; Armed Forces Health Surveillance Branch
FX This work, including the efforts of Emil Lesho, was funded by U.S. Army
Medical Command. This work, including the efforts of Emil Lesho, was
funded by Armed Forces Health Surveillance Branch.
NR 22
TC 1
Z9 1
U1 0
U2 0
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0095-1137
EI 1098-660X
J9 J CLIN MICROBIOL
JI J. Clin. Microbiol.
PD JUN
PY 2016
VL 54
IS 6
BP 1546
EP 1551
DI 10.1128/JCM.00359-16
PG 6
WC Microbiology
SC Microbiology
GA DM7HM
UT WOS:000376529200021
PM 27030488
ER
PT J
AU Edwards, MJ
Edwards, KD
White, C
Shepps, C
Shackelford, S
AF Edwards, Mary J.
Edwards, Kurt D.
White, Christopher
Shepps, Craig
Shackelford, Stacy
TI Saving the Military Surgeon: Maintaining Critical Clinical Skills in a
Changing Military and Medical Environment
SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
LA English
DT Editorial Material
ID HOSPITAL VOLUME; US MILITARY; QUALITY; CARE; EXPERIENCE; OPERATIONS;
READINESS; OUTCOMES; CENTERS; CANCER
C1 [Edwards, Mary J.; Edwards, Kurt D.; White, Christopher] San Antonio Mil Med Ctr, Dept Surg, San Antonio, TX USA.
[Shackelford, Stacy] US Army, Inst Surg Res, Dept Def Joint Trauma Syst, San Antonio, TX USA.
[Shepps, Craig] Naval Med Ctr, Dept Surg, Portsmouth, VA USA.
RP Edwards, MJ (reprint author), US Army, Dept Surg, San Antonio Mil Med Ctr, 3551 Roger Brooke Dr, San Antonio, TX 78234 USA.
EM mary.j.edwards@us.army.mil
NR 31
TC 2
Z9 2
U1 1
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1072-7515
EI 1879-1190
J9 J AM COLL SURGEONS
JI J. Am. Coll. Surg.
PD JUN
PY 2016
VL 222
IS 6
BP 1258
EP 1264
DI 10.1016/j.jamcollsurg.2016.03.031
PG 7
WC Surgery
SC Surgery
GA DM7DH
UT WOS:000376514300044
PM 27185158
ER
PT J
AU Tian, H
Chin, ML
Najmaei, S
Guo, QS
Xia, FN
Wang, H
Dubey, M
AF Tian, He
Chin, Matthew L.
Najmaei, Sina
Guo, Qiushi
Xia, Fengnian
Wang, Han
Dubey, Madan
TI Optoelectronic devices based on two-dimensional transition metal
dichalcogenides
SO NANO RESEARCH
LA English
DT Review
DE transition metal dichalcogenides (TMDCs); optoelectronic device;
molybdenum disulfide (MoS2); photodetector; light-emitting diode (LED)
ID FIELD-EFFECT TRANSISTORS; SINGLE-LAYER MOS2; MONOLAYER
MOLYBDENUM-DISULFIDE; DER-WAALS HETEROSTRUCTURES; LIGHT-EMITTING-DIODES;
P-N-JUNCTIONS; BLACK PHOSPHORUS; INPLANE HETEROSTRUCTURES; PHOTOCURRENT
GENERATION; GRAPHENE PLASMONICS
AB In the past few years, two-dimensional (2D) transition metal dichalcogenide (TMDC) materials have attracted increasing attention of the research community, owing to their unique electronic and optical properties, ranging from the valley-spin coupling to the indirect-to-direct bandgap transition when scaling the materials from multi-layer to monolayer. These properties are appealing for the development of novel electronic and optoelectronic devices with important applications in the broad fields of communication, computation, and healthcare. One of the key features of the TMDC family is the indirect-to-direct bandgap transition that occurs when the material thickness decreases from multilayer to monolayer, which is favorable for many photonic applications. TMDCs have also demonstrated unprecedented flexibility and versatility for constructing a wide range of heterostructures with atomic-level control over their layer thickness that is also free of lattice mismatch issues. As a result, layered TMDCs in combination with other 2D materials have the potential for realizing novel high-performance optoelectronic devices over a broad operating spectral range. In this article, we review the recent progress in the synthesis of 2D TMDCs and optoelectronic devices research. We also discuss the challenges facing the scalable applications of the family of 2D materials and provide our perspective on the opportunities offered by these materials for future generations of nanophotonics technology.
C1 [Tian, He; Wang, Han] Univ So Calif, Ming Hsieh Dept Elect Engn, Los Angeles, CA 90089 USA.
[Chin, Matthew L.; Najmaei, Sina; Dubey, Madan] US Army Res Lab, Adelphi, MD 20783 USA.
[Guo, Qiushi; Xia, Fengnian] Yale Univ, Dept Elect Engn, New Haven, CT 06511 USA.
RP Wang, H (reprint author), Univ So Calif, Ming Hsieh Dept Elect Engn, Los Angeles, CA 90089 USA.; Dubey, M (reprint author), US Army Res Lab, Adelphi, MD 20783 USA.
EM han.wang.4@usc.edu; madan.dubey.civ@mail.mil
RI Tian, He/I-1299-2014
OI Tian, He/0000-0001-7328-2182
FU National Science Foundation [EFMA-1542815]; Army Research Laboratory;
USC Zumberge Individual Award
FX The authors acknowledge support from the National Science Foundation
(No. EFMA-1542815), Army Research Laboratory, and USC Zumberge
Individual Award.
NR 122
TC 14
Z9 14
U1 84
U2 220
PU TSINGHUA UNIV PRESS
PI BEIJING
PA TSINGHUA UNIV, RM A703, XUEYAN BLDG, BEIJING, 10084, PEOPLES R CHINA
SN 1998-0124
EI 1998-0000
J9 NANO RES
JI Nano Res.
PD JUN
PY 2016
VL 9
IS 6
BP 1543
EP 1560
DI 10.1007/s12274-016-1034-9
PG 18
WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science,
Multidisciplinary; Physics, Applied
SC Chemistry; Science & Technology - Other Topics; Materials Science;
Physics
GA DM8ZF
UT WOS:000376652300001
ER
PT J
AU Zhao, XG
Zhang, JD
Fan, KB
Duan, GW
Metcalfe, GD
Wraback, M
Zhang, X
Averitt, RD
AF Zhao, Xiaoguang
Zhang, Jingdi
Fan, Kebin
Duan, Guangwu
Metcalfe, Grace D.
Wraback, Michael
Zhang, Xin
Averitt, Richard D.
TI Nonlinear terahertz metamaterial perfect absorbers using GaAs [Invited]
SO PHOTONICS RESEARCH
LA English
DT Article
ID FIELD; IONIZATION; PULSE
AB We investigate the nonlinear response of terahertz (THz) metamaterial perfect absorbers consisting of electric split ring resonators on GaAs integrated with a polyimide spacer and gold ground plane. These perfect absorbers on bulk semi-insulating GaAs are characterized using high-field THz time-domain spectroscopy. The resonance frequency redshifts 20 GHz and the absorbance is reduced by 30% as the incident peak field is increased from 30 to 300 kV/cm. The nonlinear response arises from THz field driven interband transitions and intervalley scattering in the GaAs. To eliminate the Fresnel losses from the GaAs substrate, we design and fabricate a flexible metamaterial saturable perfect absorber. The ability to create nonlinear absorbers enables appealing applications such as optical limiting and self-focusing. (C) 2016 Chinese Laser Press
C1 [Zhao, Xiaoguang; Fan, Kebin; Duan, Guangwu; Zhang, Xin] Boston Univ, Dept Mech Engn, 110 Cummington Mall, Boston, MA 02215 USA.
[Zhang, Jingdi; Averitt, Richard D.] Univ Calif San Diego, Dept Phys, 9500 Gilman Dr, La Jolla, CA 92093 USA.
[Metcalfe, Grace D.; Wraback, Michael] Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
RP Zhang, X (reprint author), Boston Univ, Dept Mech Engn, 110 Cummington Mall, Boston, MA 02215 USA.
EM xinz@bu.edu; raveritt@ucsd.edu
RI Fan, Kebin/B-2984-2012; Zhang, Xin/B-9244-2009
OI Fan, Kebin/0000-0002-0275-0871; Zhang, Xin/0000-0002-4413-5084
FU National Science Foundation [ECCS 1309835]; DOE-Basic Energy Sciences
[DE-SC0012592]
FX This work was supported in part by the National Science Foundation under
contract ECCS 1309835, and the DOE-Basic Energy Sciences under Grant No.
DE-SC0012592. The authors would like to thank the Boston University
Photonics Center for technical support.
NR 34
TC 0
Z9 0
U1 14
U2 32
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 2327-9125
J9 PHOTONICS RES
JI Photonics Res.
PD JUN 1
PY 2016
VL 4
IS 3
BP A16
EP A21
DI 10.1364/PRJ.4.000A16
PG 6
WC Optics
SC Optics
GA DM9BJ
UT WOS:000376658500003
ER
PT J
AU Fatichi, S
Vivoni, ER
Ogden, FL
Ivanov, VY
Mirus, B
Gochis, D
Downer, CW
Camporese, M
Davison, JH
Ebel, BA
Jones, N
Kim, J
Mascaro, G
Niswonger, R
Restrepo, P
Rigon, R
Shen, C
Sulis, M
Tarboton, D
AF Fatichi, Simone
Vivoni, Enrique R.
Ogden, Fred L.
Ivanov, Valeriy Y.
Mirus, Benjamin
Gochis, David
Downer, Charles W.
Camporese, Matteo
Davison, Jason H.
Ebel, Brian A.
Jones, Norm
Kim, Jongho
Mascaro, Giuseppe
Niswonger, Richard
Restrepo, Pedro
Rigon, Riccardo
Shen, Chaopeng
Sulis, Mauro
Tarboton, David
TI An overview of current applications, challenges, and future trends in
distributed process-based models in hydrology
SO JOURNAL OF HYDROLOGY
LA English
DT Review
DE Modeling; Interdisciplinary; Watershed processes; Virtual experiments;
Change assessments; Natural and built environment
ID ATMOSPHERIC BOUNDARY-LAYER; VARIABLY SATURATED FLOW; SURFACE PROCESSES
MODEL; EARTH SYSTEM MODELS; LAND-SURFACE; CATCHMENT-SCALE;
SOIL-MOISTURE; CLIMATE-CHANGE; DATA ASSIMILATION; RESPONSE SIMULATION
AB Process-based hydrological models have a long history dating back to the 1960s. Criticized by some as over-parameterized, overly complex, and difficult to use, a more nuanced view is that these tools are necessary in many situations and, in a certain class of problems, they are the most appropriate type of hydrological model. This is especially the case in situations where knowledge of flow paths or distributed state variables and/or preservation of physical constraints is important. Examples of this include: spatiotemporal variability of soil moisture, groundwater flow and runoff generation, sediment and contaminant transport, or when feedbacks among various Earth's system processes or understanding the impacts of climate non-stationarity are of primary concern. These are situations where process-based models excel and other models are unverifiable. This article presents this pragmatic view in the context of existing literature to justify the approach where applicable and necessary. We review how improvements in data availability, computational resources and algorithms have made detailed hydrological simulations a reality. Avenues for the future of process-based hydrological models are presented suggesting their use as virtual laboratories, for design purposes, and with a powerful treatment of uncertainty. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Fatichi, Simone] ETH, Inst Environm Engn, Stefano Franscini Pl 5,HIL D 23-2, CH-8093 Zurich, Switzerland.
[Vivoni, Enrique R.] Arizona State Univ, Sch Earth & Space Explorat, Tempe, AZ USA.
[Vivoni, Enrique R.] Arizona State Univ, Sch Sustainable Engn & Built Environm, Tempe, AZ USA.
[Ogden, Fred L.] Univ Wyoming, Dept Civil & Architectural Engn, Laramie, WY 82071 USA.
[Ivanov, Valeriy Y.; Kim, Jongho] Univ Michigan, Dept Civil & Environm Engn, Ann Arbor, MI 48109 USA.
[Mirus, Benjamin] US Geol Survey, Geol Hazards Sci Ctr, Golden, CO USA.
[Gochis, David] Natl Ctr Atmospher Res, POB 3000, Boulder, CO 80307 USA.
[Downer, Charles W.] Engn Res & Dev Ctr, Hydrol Syst Branch, Coastal & Hydraul Lab, Vicksburg, MS USA.
[Camporese, Matteo] Univ Padua, Dept Civil Environm & Architectural Engn, Padua, Italy.
[Davison, Jason H.] Univ Waterloo, Dept Earth & Environm Sci, Waterloo, ON N2L 3G1, Canada.
[Ebel, Brian A.] US Geol Survey, Natl Res Program, Box 25046, Denver, CO 80225 USA.
[Jones, Norm] Brigham Young Univ, Provo, UT 84602 USA.
[Kim, Jongho] Sejong Univ, Dept Civil & Environm Engn, Seoul, South Korea.
[Mascaro, Giuseppe] Arizona State Univ, Julie Anne Wrigley Global Inst Sustainabil, Tempe, AZ USA.
[Niswonger, Richard] US Geol Survey, Natl Res Program, 345 Middlefield Rd, Menlo Pk, CA 94025 USA.
[Restrepo, Pedro] NOAA, North Cent River Forecast Ctr, Natl Weather Serv, Chanhassen, MN USA.
[Rigon, Riccardo] Univ Trento, Dipartimen Ingn Civile Ambientale & Meccan, Trento, Italy.
[Rigon, Riccardo] Univ Trento, CUDAM, Trento, Italy.
[Shen, Chaopeng] Penn State Univ, Dept Civil & Environm Engn, University Pk, PA 16802 USA.
[Sulis, Mauro] Univ Bonn, Meteorol Inst, Bonn, Germany.
[Tarboton, David] Utah State Univ, Civil & Environm Engn, Logan, UT 84322 USA.
RP Fatichi, S (reprint author), ETH, Inst Environm Engn, Stefano Franscini Pl 5,HIL D 23-2, CH-8093 Zurich, Switzerland.
EM simone.fatichi@ifu.baug.ethz.ch
RI Vivoni, Enrique/E-1202-2012; Camporese, Matteo/I-5405-2012; Mascaro,
Giuseppe/K-5504-2013; Rigon, Riccardo/B-5395-2008;
OI Vivoni, Enrique/0000-0002-2659-9459; Camporese,
Matteo/0000-0002-7505-798X; Mascaro, Giuseppe/0000-0003-4516-1206;
Rigon, Riccardo/0000-0002-7668-5806; Ebel, Brian/0000-0002-5413-3963;
Fatichi, Simone/0000-0003-1361-6659
FU Stavros Niarchos Foundation; ETH Zurich Foundation [ETH-29 14-2]; NSF
[EAR 1151443]; Deutsche Forschungsgemeinschaft (DFG) [SFB/TR32]
FX This article resulted from discussions held during the session "High
Resolution Hydrologic Modeling: Challenges and Avenues for Development"
at the American Geophysical Union Fall Meeting 2013 in San Francisco,
USA. Luke McGuire, USGS, provided a useful review of an earlier draft of
this manuscript. We thank Massimo Dotti for the references about
astrophysics. SF thanks the support of the Stavros Niarchos Foundation
and the ETH Zurich Foundation (Grant ETH-29 14-2). VI acknowledges the
support of NSF Grant EAR 1151443. MS acknowledges financial support from
SFB/TR32 (Patterns in Soil-Vegetation-Atmosphere Systems: Monitoring,
Modeling, and Data Assimilation) funded by the Deutsche
Forschungsgemeinschaft (DFG). Any use of trade, firm, or product names
is for descriptive purposes only and does not imply endorsement by the
U.S. Government.
NR 290
TC 13
Z9 13
U1 65
U2 115
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-1694
EI 1879-2707
J9 J HYDROL
JI J. Hydrol.
PD JUN
PY 2016
VL 537
BP 45
EP 60
DI 10.1016/j.jhydrol.2016.03.026
PG 16
WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources
SC Engineering; Geology; Water Resources
GA DM2XU
UT WOS:000376212200007
ER
PT J
AU Boucher, R
Kang, W
Gong, Q
AF Boucher, Randy
Kang, Wei
Gong, Qi
TI Galerkin Optimal Control
SO JOURNAL OF OPTIMIZATION THEORY AND APPLICATIONS
LA English
DT Article
DE Optimal control; Constrained optimization; Pseudospectral; Galerkin
ID FEEDBACK LINEARIZABLE SYSTEMS; FINITE-ELEMENT DISCRETIZATION;
PSEUDOSPECTRAL METHODS; CONTROL CONSTRAINTS; CONVERGENCE; EQUATIONS
AB This paper introduces a family of computational methods for solving optimal control problems that calculate optimal trajectories using Galerkin numerical techniques. An important result in the theoretical foundation of these methods is that their associated feasibility and consistency theorems are proved for problems with continuous and/or piecewise continuous controls. In this paper we demonstrate that Galerkin numerical techniques allow for the formulation of optimal control problems in a number of ways that allow for efficiency and/or improved accuracy. The family of Galerkin methods presented can solve a wide range of optimal control problems with a variety of state and control constraints. Numerical formulations using Lagrangian and Legendre test functions are derived. Finally, numerical examples demonstrate the versatile nature of various Galerkin optimal control formulations.
C1 [Boucher, Randy] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA.
[Kang, Wei] Naval Postgrad Sch, Dept Appl Math, Monterey, CA USA.
[Gong, Qi] Univ Calif Santa Cruz, Dept Appl Math & Stat, Santa Cruz, CA 95064 USA.
RP Kang, W (reprint author), Naval Postgrad Sch, Dept Appl Math, Monterey, CA USA.
EM randy.boucher@usma.edu; wkang@nps.edu; qigong@soe.ucsc.edu
FU Air Force Office of Scientific Research (AFOSR); Naval Research
Laboratory (NRL)
FX This work was supported in part by the Air Force Office of Scientific
Research (AFOSR) and the Naval Research Laboratory (NRL). The work and
views expressed in this paper are those of the authors and do not
reflect the official policy or position of the Department of the Army,
the Department of the Navy, the Department of Defense, or the U.S.
Government.
NR 28
TC 0
Z9 0
U1 0
U2 2
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0022-3239
EI 1573-2878
J9 J OPTIMIZ THEORY APP
JI J. Optim. Theory Appl.
PD JUN
PY 2016
VL 169
IS 3
BP 825
EP 847
DI 10.1007/s10957-016-0918-x
PG 23
WC Operations Research & Management Science; Mathematics, Applied
SC Operations Research & Management Science; Mathematics
GA DM4CS
UT WOS:000376293800007
ER
PT J
AU Morgan, AB
Yip, PW
AF Morgan, Alexander B.
Yip, Pearl W.
TI Effects of laundering on military uniform fabric flammability
SO FIRE AND MATERIALS
LA English
DT Article
DE textiles; flame spread testing; pyrolysis GC-MS; cone calorimeter;
pyrolysis combustion flow calorimetry
ID TEXTILES; CALORIMETRY
AB In this paper, the effects of laundering on the flammability of a military uniform fabric were studied. The flame retardant was incorporated into the fiber prior to fiber spinning, and its ability to maintain flame spread and flame retardancy was evaluated by multiple test methods. Vertical flame spread, cone calorimeter, and pyrolysis combustion flow calorimetry were used to determine how many of the flame retardants were removed as a function of wash cycles and if there was any measurable reduction in heat release/fire safety performance that correlated with a loss in flame retardant from washing. Fire testing showed that flame spread performance was maintained within the normal error for the measurement and heat release testing showed very little difference between samples as a function of laundering. Additional analysis via pyrolysis gas chromatography-mass spectrometry showed that while the flame retardant levels did decrease with washing, enough of the material remained embedded in the fibers so that fire performance could be maintained. The results do indicate that the flame retardant can be washed off, but because of the flame retardant being deeply embedded in the fiber, enough will remain with the fabric after 25 washes to maintain flame retardant performance. Copyright (c) 2015 John Wiley & Sons, Ltd.
C1 [Morgan, Alexander B.] Univ Dayton, Res Inst, Energy Technol & Mat Div, 300 Coll Pk, Dayton, OH 45469 USA.
[Yip, Pearl W.] US Army, Natick Soldier Res Dev & Engn Ctr, Mol Sci & Engn Team, Natick, MA 01760 USA.
RP Morgan, AB (reprint author), Univ Dayton, Res Inst, Energy Technol & Mat Div, 300 Coll Pk, Dayton, OH 45469 USA.
EM alexander.morgan@udri.udayton.edu
FU US Army [W6QK ACC-14-P-0043]
FX The authors would like to thank Wayne Muller and Margaret Auerbach of
NSRDEC for their guidance and assistance in the Vertical Flame Test
measurements. Special thanks also go to Celia Powell of NSRDEC for
sharing her materials, expertise, and experimental data. The authors
also wish to thank Mary Galaska, Becki Glagola, and Kathy Schenck of
UDRI for their assistance with PCFC and cone calorimeter testing.
Funding for this work was provided under US Army contract number W6QK
ACC-14-P-0043.
NR 17
TC 0
Z9 0
U1 6
U2 10
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0308-0501
EI 1099-1018
J9 FIRE MATER
JI Fire Mater.
PD JUN
PY 2016
VL 40
IS 4
BP 599
EP 611
DI 10.1002/fam.2313
PG 13
WC Materials Science, Multidisciplinary
SC Materials Science
GA DJ8WM
UT WOS:000374494100007
ER
PT J
AU Kessens, CC
Desai, JP
AF Kessens, Chad C.
Desai, Jaydev P.
TI Versatile Passive Grasping for Manipulation
SO IEEE-ASME TRANSACTIONS ON MECHATRONICS
LA English
DT Article
DE Grasping; manipulation; shape memory alloy; suction; unknown object
ID ACTUATOR; DRIVEN; ROBOT; HAND
AB As a robot's tasks become increasingly diverse, an end-effector's ability to grasp the widest possible range of object shapes and sizes will be paramount. In previous work, we demonstrated the potential of our patented self-sealing suction cup technology to expand upon the traditional grasping techniques. In this paper, we improve upon the original design by making it smaller and more robust, develop a new compact, SMA-actuated three-finger hand utilizing these cups, and introduce a release system. We then characterize the cup performance showing a self-seal quality, leak rate, object seal and reseal quality, life cycle performance, normal force-displacement response, and shear force response. Finally, we characterize the hand performance showing a range of motion, force, and grasp and release of several objects using the new three-finger hand attached to a PA-10 robot manipulator.
C1 [Kessens, Chad C.; Desai, Jaydev P.] Univ Maryland, Dept Mech Engn, Robot Automat & Med Syst Lab, College Pk, MD 20740 USA.
[Kessens, Chad C.] US Army, Res Lab, Adelphi, MD 20783 USA.
RP Kessens, CC; Desai, JP (reprint author), Univ Maryland, Dept Mech Engn, Robot Automat & Med Syst Lab, College Pk, MD 20740 USA.; Kessens, CC (reprint author), US Army, Res Lab, Adelphi, MD 20783 USA.
EM ckessens@umd.edu; jaydev@umd.edu
NR 30
TC 0
Z9 0
U1 4
U2 4
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1083-4435
EI 1941-014X
J9 IEEE-ASME T MECH
JI IEEE-ASME Trans. Mechatron.
PD JUN
PY 2016
VL 21
IS 3
BP 1293
EP 1302
DI 10.1109/TMECH.2016.2520306
PG 10
WC Automation & Control Systems; Engineering, Manufacturing; Engineering,
Electrical & Electronic; Engineering, Mechanical
SC Automation & Control Systems; Engineering
GA DL4MC
UT WOS:000375609900010
ER
PT J
AU Habtour, E
Cole, DP
Stanton, SC
Sridharan, R
Dasgupta, A
AF Habtour, Ed
Cole, Daniel P.
Stanton, Samuel C.
Sridharan, Raman
Dasgupta, Abhijit
TI Damage precursor detection for structures subjected to rotational base
vibration
SO INTERNATIONAL JOURNAL OF NON-LINEAR MECHANICS
LA English
DT Article
DE Damage precursor; fatigue; nonlinear vibration; damage detection;
gyroscopic
ID CANTILEVER BEAM; TORSIONAL DYNAMICS; FLEXIBLE BEAMS; MODULUS;
NANOINDENTATION; HARVESTERS; BEHAVIOR; HARDNESS; MOTION; STEEL
AB This paper presents a nonlinear dynamic methodology for monitoring precursors of fatigue damage in metallic structures under variable rotational base excitation. The methodology accounts for important nonlinearities due to the complex loading generated by variable rotation and structural degradation. The sources of the nonlinearities include: structural stiffening due to gyroscopic motion and high-response amplitude at the fundamental mode, softening due to inertial forces and gyroscopic loads, and localized microscopic material damage and micro-plasticity. The loading intensity and number of vibration cycles increase the influence of these effects. The change in the dynamic response due to fatigue damage accumulation is experimentally investigated by exciting a cantilever beam at variable rotational base motions. The observed fatigue evolution in the material microstructure at regions of large stresses (and the resulting progressive structural softening) is tracked by quantifying the growth in the tip response, the change in the fundamental natural frequency of the beam and the skewedness of the stepped-sine response curve. Previous understanding of the structural dynamic behavior is necessary to ascertain the damage precursor location and evolution. Nanoindentation studies near the beam clamped boundary are conducted to confirm the gradual progression in the local mechanical properties as a function of loading cycles, and microstructural studies are conducted to obtain qualitative preliminary insights into the microstructure evolution. This study demonstrates that careful monitoring of the nonlinearities in the structural dynamic response can be a sensitive parameter for detection of damage precursors. Published by Elsevier Ltd.
C1 [Habtour, Ed; Cole, Daniel P.] Vehicle Technol Directorate, US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Stanton, Samuel C.] US Army Res Off, Mech Sci, Aberdeen Proving Ground, MD 21005 USA.
[Sridharan, Raman; Dasgupta, Abhijit] Univ Maryland, Ctr Adv Life Cycle Engn, College Pk, MD 20742 USA.
RP Habtour, E (reprint author), Vehicle Technol Directorate, US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM ed.m.habtour.civ@mail.mil
OI Habtour, Ed/0000-0002-9083-9285
FU Center for Advanced Life Cycle Engineering (CALCE) at the University of
Maryland; U.S. Army Research Laboratory (ARL); University of Maryland
under ARL Open-Campus Initiative
FX This research effort was funded by the sponsors of the Center for
Advanced Life Cycle Engineering (CALCE) at the University of Maryland
and was further supported by a Collaborative Research and Development
Agreement (CRADA) between the U.S. Army Research Laboratory (ARL) and
the University of Maryland under ARL Open-Campus Initiative.
NR 54
TC 1
Z9 1
U1 2
U2 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0020-7462
EI 1878-5638
J9 INT J NONLIN MECH
JI Int. J. Non-Linear Mech.
PD JUN
PY 2016
VL 82
BP 49
EP 58
DI 10.1016/j.ijnonlinmec.2016.02.009
PG 10
WC Mechanics
SC Mechanics
GA DL7KF
UT WOS:000375818900006
ER
PT J
AU Kasantikul, T
Visessripong, A
Chatrungreungkul, S
Lombardini, ED
Sirimanapong, W
AF Kasantikul, T.
Visessripong, A.
Chatrungreungkul, S.
Lombardini, E. D.
Sirimanapong, W.
TI Suspected thymic lymphoma with invasion of the gills in a gold crossback
arowana (Scleropages formosus)
SO JOURNAL OF FISH DISEASES
LA English
DT Article
DE crossback arowana; neoplasm; Scleropages formosus; thymic lymphoma
ID MEDAKA ORYZIAS-LATIPES; LYMPHOBLASTIC LYMPHOMA; CHANNEL CATFISH;
LYMPHOSARCOMA; TROUT; FISH
C1 [Kasantikul, T.; Chatrungreungkul, S.] Mahidol Univ, Fac Vet Sci, Ctr Vet Diag, Salaya, Nakhon Pathom, Thailand.
[Visessripong, A.; Sirimanapong, W.] Mahidol Univ, Fac Vet Sci, Dept Clin Sci & Publ Hlth, 999 Phutthamonthon Sai 4 Rd, Salaya 73170, Nakhon Pathom, Thailand.
[Lombardini, E. D.] Armed Forces Res Inst Med Sci, Dept Vet Med, Div Comparat Pathol, Bangkok 10400, Thailand.
[Lombardini, E. D.] Armed Forces Res Inst Med Sci, Dept Vet Med, Div Vet Med Res, Bangkok 10400, Thailand.
RP Sirimanapong, W (reprint author), Mahidol Univ, Fac Vet Sci, Dept Clin Sci & Publ Hlth, 999 Phutthamonthon Sai 4 Rd, Salaya 73170, Nakhon Pathom, Thailand.
EM wanna.sir@mahidol.ac.th
NR 21
TC 0
Z9 0
U1 0
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0140-7775
EI 1365-2761
J9 J FISH DIS
JI J. Fish Dis.
PD JUN
PY 2016
VL 39
IS 6
BP 783
EP 786
DI 10.1111/jfd.12424
PG 4
WC Fisheries; Marine & Freshwater Biology; Veterinary Sciences
SC Fisheries; Marine & Freshwater Biology; Veterinary Sciences
GA DL6XO
UT WOS:000375783600016
PM 26596259
ER
PT J
AU Oliveira, AS
Schlink, BR
Hairston, WD
Konig, P
Ferris, DP
AF Oliveira, Anderson S.
Schlink, Bryan R.
Hairston, W. David
Koenig, Peter
Ferris, Daniel P.
TI Induction and separation of motion artifacts in EEG data using a mobile
phantom head device
SO JOURNAL OF NEURAL ENGINEERING
LA English
DT Article
DE EEG; motion artifacts; ICA; signal-to-noise ratio; phantom head;
walking; locomotion
ID VISUAL-EVOKED RESPONSES; HUMAN SKULL PHANTOM; SOURCE LOCALIZATION;
TREADMILL WALKING; BRAIN; ELECTROENCEPHALOGRAM; ACCELERATIONS; DYNAMICS;
HUMANS
AB Objective. Electroencephalography (EEG) can assess brain activity during whole-body motion in humans but head motion can induce artifacts that obfuscate electrocortical signals. Definitive solutions for removing motion artifact from EEG have yet to be found, so creating methods to assess signal processing routines for removing motion artifact are needed. We present a novel method for investigating the influence of head motion on EEG recordings as well as for assessing the efficacy of signal processing approaches intended to remove motion artifact. Approach. We used a phantom head device to mimic electrical properties of the human head with three controlled dipolar sources of electrical activity embedded in the phantom. We induced sinusoidal vertical motions on the phantom head using a custom-built platform and recorded EEG signals with three different acquisition systems while the head was both stationary and in varied motion conditions. Main results. Recordings showed up to 80% reductions in signal-to-noise ratio (SNR) and up to 3600% increases in the power spectrum as a function of motion amplitude and frequency. Independent component analysis (ICA) successfully isolated the three dipolar sources across all conditions and systems. There was a high correlation (r >. 0.85) and marginal increase in the independent components' (ICs) power spectrum (similar to 15%) when comparing stationary and motion parameters. The SNR of the IC activation was 400%-700% higher in comparison to the channel data SNR, attenuating the effects of motion on SNR. Significance. Our results suggest that the phantom head and motion platform can be used to assess motion artifact removal algorithms and compare different EEG systems for motion artifact sensitivity. In addition, ICA is effective in isolating target electrocortical events and marginally improving SNR in relation to stationary recordings.
C1 [Oliveira, Anderson S.; Schlink, Bryan R.; Ferris, Daniel P.] Univ Michigan, Sch Kinesiol, Human Neuromech Lab, Ann Arbor, MI 48109 USA.
[Hairston, W. David] US Army Res Lab, Aberdeen Proving Ground, MD USA.
[Koenig, Peter] Univ Osnabruck, Osnabruck, Germany.
[Koenig, Peter] Univ Med Ctr Hamburg Eppendorf, Hamburg, Germany.
RP Oliveira, AS (reprint author), Univ Michigan, Sch Kinesiol, Human Neuromech Lab, Ann Arbor, MI 48109 USA.
EM oliveira_dkbr@hotmail.com
OI Oliveira, Anderson/0000-0003-2186-8100
FU Cognition and Neuroergonomics Collaborative Technology Alliance [ARL
W911NF-10-2-0022]
FX Research supported by the Cognition and Neuroergonomics Collaborative
Technology Alliance ARL W911NF-10-2-0022.
NR 31
TC 0
Z9 0
U1 2
U2 3
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 1741-2560
EI 1741-2552
J9 J NEURAL ENG
JI J. Neural Eng.
PD JUN
PY 2016
VL 13
IS 3
AR 036014
DI 10.1088/1741-2560/13/3/036014
PG 14
WC Engineering, Biomedical; Neurosciences
SC Engineering; Neurosciences & Neurology
GA DL5TZ
UT WOS:000375701200018
PM 27137818
ER
PT J
AU Esposito, ER
Whitehead, JMA
Wilken, JM
AF Esposito, Elizabeth Russell
Whitehead, Jennifer M. Aldridge
Wilken, Jason M.
TI Step-to-step transition work during level and inclined walking using
passive and powered ankle-foot prostheses
SO PROSTHETICS AND ORTHOTICS INTERNATIONAL
LA English
DT Article
DE Energetics; transtibial; hill; biomechanics
ID BELOW-KNEE AMPUTEES; MECHANICAL WORK; TRANSTIBIAL AMPUTATION; ENERGETIC
CONSEQUENCES; BIOMECHANICAL ANALYSIS; DOWNHILL WALKING; GAIT; FEET;
AMBULATION; EXPENDITURE
AB Background: Individuals with leg amputations who use passive prostheses have greater metabolic demands than non-amputees likely due to limited net positive work compared to a biological ankle. New powered ankle-foot prostheses can perform net positive mechanical work to aid push-off capabilities, which may reduce metabolic demands.
Objectives: Compare step-to-step transition work and metabolic demand during level and inclined walking using passive and powered ankle-foot prostheses.
Study Design: Repeated measures.
Methods: Six individuals with transtibial amputation and six able-bodied controls walked at a standardized speed across level ground and up a 5 degrees incline. Calculated measures included mechanical work during step-to-step transitions from the trailing prosthetic to leading intact limb, steady state metabolic rate, and ankle joint kinetics and kinematics.
Results: The powered prosthesis generated 63% greater trailing limb step-to-step transition work than the passive during level walking only (p=0.004). Metabolic rate was lower with the powered prosthesis during level (p=0.006) but not inclined walking (p=0.281). The powered prosthesis increased ankle power compared to the passive, to the extent that power was normalized to controls during inclined walking and greater than controls during level walking.
Conclusion: The powered prosthesis improved ankle power, metabolic rate, and step-to-step transition work on level ground, with few negative consequences on inclines. These results may be used to guide the development and use of actively powered prosthetic devices in high-functioning individuals.
Clinical relevance Overall, powered devices offer biomechanical and metabolic benefits over passive energy storage and return designs on level ground and perform as well as a passive model on inclines. The lower metabolic demand when using the powered device may delay fatigue for individuals with transtibial amputation when walking over level ground.
C1 [Esposito, Elizabeth Russell; Whitehead, Jennifer M. Aldridge; Wilken, Jason M.] Brooke Army Med Ctr, Ctr Intrepid, 3551 Roger Brooke Dr, Houston, TX 78234 USA.
RP Esposito, ER (reprint author), Brooke Army Med Ctr, Ctr Intrepid, 3551 Roger Brooke Dr, Houston, TX 78234 USA.
EM erussell.kin@gmail.com
FU Center for Rehabilitation Sciences Research (CRSR), Department of
Physical Medicine and Rehabilitation, Uniformed Services University of
Health Sciences, Bethesda, MD; US Army Telemedicine & Advanced
Technology Research Center (TATRC)
FX Support was provided by the Center for Rehabilitation Sciences Research
(CRSR), Department of Physical Medicine and Rehabilitation, Uniformed
Services University of Health Sciences, Bethesda, MD, and US Army
Telemedicine & Advanced Technology Research Center (TATRC).
NR 34
TC 2
Z9 2
U1 5
U2 11
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0309-3646
EI 1746-1553
J9 PROSTHET ORTHOT INT
JI Prosthet. Orthot. Int.
PD JUN
PY 2016
VL 40
IS 3
BP 311
EP 319
DI 10.1177/0309364614564021
PG 9
WC Orthopedics; Rehabilitation
SC Orthopedics; Rehabilitation
GA DL5TD
UT WOS:000375698900003
ER
PT J
AU Khamkanya, A
Cho, BR
Goethals, PL
AF Khamkanya, Anintaya
Cho, Byung Rae
Goethals, Paul L.
TI Integrating Customer Perception into Process Capability Measures
SO QUALITY AND RELIABILITY ENGINEERING INTERNATIONAL
LA English
DT Article
DE process capability; customer-perceived capability indices; truncated
normal distribution; Johnson transformation
ID NORMAL-DISTRIBUTIONS; NONNORMAL DATA; INDEXES; OPTIMIZATION
AB Process capability indices provide a measure of the output of an in-control process that conforms to a set of specification limits. These measures, which assume that process output is approximately normally distributed, are intended for measuring process capability for manufacturing systems. When the performance of a system results in a product that fails to fall within a given specification range, however, the product is typically scrapped or reworked, and the actual distribution that the customer perceives after inspection is truncated. In this paper, the concept of a truncated measure for three types of quality characteristics is introduced as the key to linking customer perception to process capability. Subsequently, a set of customer-perceived process capability indices is presented as an extension of traditional manufacturer-based counterparts. Finally, data transformation-based process capability indices are also discussed. A comparative study and numerical example reveal considerable differences among the traditional and proposed process capability indices. It is believed that the proposed process capability index for various quality characteristics may more aptly lead to process improvement by facilitating a better understanding of the integrated effects found in engineering design problems. Copyright (c) 2015 John Wiley & Sons, Ltd.
C1 [Khamkanya, Anintaya; Cho, Byung Rae] Clemson Univ, Dept Ind Engn, Clemson, SC USA.
[Goethals, Paul L.] US Mil Acad, West Point, NY 10996 USA.
RP Goethals, PL (reprint author), US Mil Acad, West Point, NY 10996 USA.
EM paul.goethals@yahoo.com
NR 36
TC 0
Z9 0
U1 1
U2 6
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0748-8017
EI 1099-1638
J9 QUAL RELIAB ENG INT
JI Qual. Reliab. Eng. Int.
PD JUN
PY 2016
VL 32
IS 4
BP 1331
EP 1345
DI 10.1002/qre.1833
PG 15
WC Engineering, Multidisciplinary; Engineering, Industrial; Operations
Research & Management Science
SC Engineering; Operations Research & Management Science
GA DK1OB
UT WOS:000374681200006
ER
PT J
AU Beck, R
Zhan, SG
Liu, HX
Tong, S
Yang, B
Xu, M
Ye, ZX
Huang, Y
Shu, S
Wu, QS
Wang, SJ
Berling, K
Murray, A
Emery, E
Reif, M
Harwood, J
Young, J
Nietch, C
Macke, D
Martin, M
Stillings, G
Stump, R
Su, HB
AF Beck, Richard
Zhan, Shengan
Liu, Hongxing
Tong, Susanna
Yang, Bo
Xu, Min
Ye, Zhaoxia
Huang, Yan
Shu, Song
Wu, Qiusheng
Wang, Shujie
Berling, Kevin
Murray, Andrew
Emery, Erich
Reif, Molly
Harwood, Joseph
Young, Jade
Nietch, Christopher
Macke, Dana
Martin, Mark
Stillings, Garrett
Stump, Richard
Su, Haibin
TI Comparison of satellite reflectance algorithms for estimating
chlorophyll-a in a temperate reservoir using coincident hyperspectral
aircraft imagery and dense coincident surface observations
SO REMOTE SENSING OF ENVIRONMENT
LA English
DT Article
DE Chlorophyll-a; Algal bloom; Harmful algal bloom; Algorithm; Satellite;
Hyperspectral; Multispectral
ID TURBID PRODUCTIVE WATERS; REMOTE-SENSING METHODS; THEMATIC MAPPER DATA;
SPECTRAL REFLECTANCE; ALGAL CHLOROPHYLL; INLAND WATERS; OCEAN COLOR; 700
NM; QUALITY; LAKE
AB We compared 10 established and 2 new satellite reflectance algorithms for estimating chlorophyll-a (Chl-a) in a temperate reservoir in southwest Ohio using coincident hyperspectral aircraft imagery and dense coincident surface observations collected within 1 h of image acquisition to develop simple proxies for algal blooms in water bodies sensitive to algal blooms (especially toxic or harmful algal blooms (HABs)) and to facilitate portability between multispectral satellite imagers for regional algal bloom monitoring. All algorithms were compared with narrow band hyperspectral aircraft images. These images were subsequently upscaled spectrally and spatially to simulate 5 current and near future satellite imaging systems. Established and new Chl-a algorithms were then applied to the synthetic satellite images and compared to coincident surface observations of Chl-a collected from 44 sites within 1 h of aircraft acquisition of the imagery. We found several promising algorithm/satellite imager combinations for routine Chl-a estimation in smaller inland water bodies with operational and near-future satellite systems. The CI, MCI, FLH, NDCI, 2BDA and 3 BDA Chl-a algorithms worked well with CASI imagery. The NDCI, 2BDA, and 3BDA Chl-a algorithms worked well with simulated WorldView-2 and 3, Sentinel-2, and MERIS-like imagery. NDCI was the most widely applicable Chl-a algorithm with good performance for CASI, WorldView 2 and 3, Sentinel-2 and MERIS-like imagery and limited performance with MODIS imagery. A new fluorescence line height "greenness" algorithm yielded the best Chl-a estimates with simulated Landsat-8 imagery. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Beck, Richard; Zhan, Shengan; Liu, Hongxing; Tong, Susanna; Yang, Bo; Xu, Min; Ye, Zhaoxia; Huang, Yan; Shu, Song; Wu, Qiusheng; Wang, Shujie; Berling, Kevin; Murray, Andrew] Univ Cincinnati, Dept Geog, Cincinnati, OH 45221 USA.
[Emery, Erich] US Army, Corps Engineers, Great Lakes & Ohio River Div, Cincinnati, OH 45202 USA.
[Reif, Molly; Harwood, Joseph] US Army, Corps Engineers, Erdc, JALBTCX, Kiln, MS 39556 USA.
[Young, Jade] US Army, Corps Engineers, Water Qual, Louisville, KY 40202 USA.
[Nietch, Christopher; Macke, Dana] US EPA, Cincinnati, OH 45268 USA.
[Martin, Mark; Stillings, Garrett; Stump, Richard] Kentucky Dept Environm Protect, Div Water, Frankfort, KY 40601 USA.
NOAA, Natl Ocean Serv, Silver Spring, MD USA.
[Su, Haibin] Texas A&M Kingsville, Dept Phys & Geosci, Kingsville, TX 78363 USA.
RP Beck, R (reprint author), Univ Cincinnati, Dept Geog, Cincinnati, OH 45221 USA.
EM richard.beck@uc.edu; zhansn@mail.uc.edu; hongxing.liu@uc.edu;
susana.tong@uc.edu; yangb2@mail.uc.edu; xum4@mail.uc.edu;
yeza@ucmail.uc.edu; huang2y2@ucmail.uc.edu; shusg@mail.uc.edu;
wuqe@mail.uc.edu; wang2sj@mail.uc.edu; berlinkj@mail.uc.edu;
murraya2@mail.uc.edu; erich.b.emery@usace.army.mil;
molly.k.reif@usace.army.mil; joseph.h.harwood@usace.army.mil;
jade.l.young@usace.army.mil; nietch.christopher@epa.gov;
macke.dana@epa.gov; mark.martin@ky.gov; garrett.stillings@ky.gov;
richard.stumpf@noaa.gov; haibin.su@tamuk.edu
OI Su, Haibin/0000-0002-3645-2047; Zhan, Shengan/0000-0002-9303-1249; Wu,
Qiusheng/0000-0001-5437-4073; Tong, Susanna /0000-0003-0308-5890
FU U.S. Army Corps of Engineers
FX This study was funded by the U.S. Army Corps of Engineers. The U.S.
Environmental Protection Agency and the Kentucky Department of
Environmental Protection, Division of Water provided valuable in-kind
services. Any use of trade, product, or firm names is for descriptive
purposes only and does not imply endorsement by the U.S. Government.
This article expresses only the personal views of the U.S. Army Corps of
Engineers employees listed as authors and does not necessarily reflect
the official positions of the Corps or of the Department of the Army.
NR 78
TC 0
Z9 0
U1 13
U2 24
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0034-4257
EI 1879-0704
J9 REMOTE SENS ENVIRON
JI Remote Sens. Environ.
PD JUN 1
PY 2016
VL 178
BP 15
EP 30
DI 10.1016/j.rse.2016.03.002
PG 16
WC Environmental Sciences; Remote Sensing; Imaging Science & Photographic
Technology
SC Environmental Sciences & Ecology; Remote Sensing; Imaging Science &
Photographic Technology
GA DL3BC
UT WOS:000375508200002
ER
PT J
AU Tier, D
AF Tier, David
TI What mix of brigade combat teams should the US Army Field?
SO SMALL WARS AND INSURGENCIES
LA English
DT Article
DE National defense; US Army; force structure; brigade combat teams (BCTs)
AB During the past decade of war, the US Army has employed its forces in roles they were not intended to fulfill. The Army could have been better prepared if it had fielded a better mixture of forces. Instead of focusing on specific threats that narrowly specify which conflicts the Army will best be prepared for, the Army should maintain a broad range of capabilities that can meet a variety of circumstances. Accordingly, the Army should seek a force structure that exhibits a 3:1:1 ratio of Infantry, Armor, and Stryker brigade combat teams (BCTs) based on the possible range of conditions that US forces could face.
C1 [Tier, David] US Army, Washington, DC USA.
RP Tier, D (reprint author), US Army, Washington, DC USA.
EM davidtier@yahoo.com
NR 6
TC 0
Z9 0
U1 1
U2 1
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 0959-2318
EI 1743-9558
J9 SMALL WAR INSUR
JI Small War Insur.
PD JUN
PY 2016
VL 27
IS 3
SI SI
BP 538
EP 549
DI 10.1080/09592318.2016.1151661
PG 12
WC International Relations
SC International Relations
GA DK4OU
UT WOS:000374898800009
ER
PT J
AU Wesley, MJ
Cheung, KF
AF Wesley, Matthew J.
Cheung, Kwok Fai
TI Modeling of wave overtopping on vertical structures with the HLLS
Riemann solver
SO COASTAL ENGINEERING
LA English
DT Article
DE Bottom discontinuities; Finite volume; Riemann solver; Shock-capturing;
Vertical breakwater; Wave overtopping
ID SHALLOW-WATER EQUATIONS; SOURCE TERMS; WAF METHOD; RUN-UP; TOPOGRAPHY;
SIMULATION; INUNDATION; SCHEMES; FLOWS
AB Depth-integrated wave models are commonly used in coastal engineering design and studies of near-shore processes, but the results might be unstable or questionable when overtopping of vertical structures is involved. The FILLS Riemann solver presented by Murillo and Garcia-Navarro (2012, Journal of Computational Physics) can account for shallow-water flow across a bottom step. We implement this solver in a second-order MUSCL-Hancock scheme and explore its use to describe overtopping of vertical structures through a nonlinear shallow-water model in one dimension. A series of numerical tests based on the Riemann problem assesses the characteristic approximation of the flow resulting from two-dimensional processes at the step. The model gives good agreement with simulations from OpenFOAM (an open-source computational fluid dynamics code) for rarefaction and surge and qualitative description for reflection at the step and shock waves generated by free fall of water. A laboratory experiment was conducted in a 9.14 m long flume to provide validation data for solitary wave overtopping of a vertical structure. Consistent with the numerical tests, the model produces slightly larger reflected waves from the structure and underestimates the amplitude and speed of the downstream waves generated by overtopping. Despite its simplicity, the HLLS solver performs reasonably well in approximating the overall processes and produces stable and efficient numerical results for practical application. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Wesley, Matthew J.; Cheung, Kwok Fai] Univ Hawaii Manoa, Dept Ocean & Resources Engn, Honolulu, HI 96822 USA.
[Wesley, Matthew J.] US Army Corps Engineers, Coastal Engn Sect, 915 Wilshire Blvd,Ste 930, Los Angeles, CA 90017 USA.
RP Cheung, KF (reprint author), Univ Hawaii Manoa, Dept Ocean & Resources Engn, Honolulu, HI 96822 USA.
EM Matthew.Wesley@usace.army.mil; cheung@hawaii.edu
FU Office of Naval Research [N00014-12-1-0721]; National Tsunami Hazard
Mitigation Program through Hawaii Emergency Management Agency
[NA14NWS4670042]
FX The study was funded by the Office of Naval Research under Grant No.
N00014-12-1-0721. Additional support was provided by the National
Tsunami Hazard Mitigation Program under Grant No. NA14NWS4670042 through
Hawaii Emergency Management Agency. We would like to thank the
Department of Civil and Environmental Engineering, University of Hawaii
for the use of the hydraulic laboratory and the two anonymous reviewers
for their constructive criticisms. SOEST Contribution No. 9581.
NR 32
TC 0
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U1 6
U2 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-3839
EI 1872-7379
J9 COAST ENG
JI Coast. Eng.
PD JUN
PY 2016
VL 112
BP 28
EP 43
DI 10.1016/j.coastaleng.2016.02.002
PG 16
WC Engineering, Civil; Engineering, Ocean
SC Engineering
GA DL3AO
UT WOS:000375506800004
ER
PT J
AU Mckay, SK
Freeman, MC
Covich, AP
AF McKay, S. Kyle
Freeman, Mary C.
Covich, Alan P.
TI Application of Effective Discharge Analysis to Environmental Flow
Decision-Making
SO ENVIRONMENTAL MANAGEMENT
LA English
DT Article
DE Flow regime; Functional-equivalent discharge; Hierarchical linear
models; Water management; Trait-based models
ID FRESH-WATER; HYDROLOGIC ALTERATION; FISH ASSEMBLAGES; ECOLOGICAL
CONSEQUENCES; RIVER SYSTEMS; STREAMS; REGIMES; VARIABILITY; ECOSYSTEMS;
DYNAMICS
AB Well-informed river management decisions rely on an explicit statement of objectives, repeatable analyses, and a transparent system for assessing trade-offs. These components may then be applied to compare alternative operational regimes for water resource infrastructure (e.g., diversions, locks, and dams). Intra- and inter-annual hydrologic variability further complicates these already complex environmental flow decisions. Effective discharge analysis (developed in studies of geomorphology) is a powerful tool for integrating temporal variability of flow magnitude and associated ecological consequences. Here, we adapt the effectiveness framework to include multiple elements of the natural flow regime (i.e., timing, duration, and rate-of-change) as well as two flow variables. We demonstrate this analytical approach using a case study of environmental flow management based on long-term (60 years) daily discharge records in the Middle Oconee River near Athens, GA, USA. Specifically, we apply an existing model for estimating young-of-year fish recruitment based on flow-dependent metrics to an effective discharge analysis that incorporates hydrologic variability and multiple focal taxa. We then compare three alternative methods of environmental flow provision. Percentage-based withdrawal schemes outcompete other environmental flow methods across all levels of water withdrawal and ecological outcomes.
C1 [McKay, S. Kyle] US Army, Engn Res & Dev Ctr, Environm Lab, Athens, GA USA.
[Freeman, Mary C.] US Geol Survey, Patuxent Wildlife Res Ctr, Athens, GA USA.
[Covich, Alan P.] Univ Georgia, Odum Sch Ecol, Athens, GA 30602 USA.
RP Mckay, SK (reprint author), US Army, Engn Res & Dev Ctr, Environm Lab, Athens, GA USA.
EM kyle.mckay@usace.army.mil
FU U.S. Army Corps of Engineers
FX The U.S. Army Corps of Engineers funded this research through the
Ecosystem Management and Restoration Research Program
(http://www.el.erdc.usace.army.mil/emrrp/) and the long-term training
program. The opinions reflected here are those of the authors and do not
necessarily reflect those of the agency. Any use of trade, product, or
firm names is for descriptive purposes only and does not imply
endorsement by the U.S. Government. Rhett Jackson, John Schramski, and
three anonymous referees reviewed a prior version of this document, and
their constructive feedback is appreciated.
NR 75
TC 0
Z9 0
U1 6
U2 23
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-152X
EI 1432-1009
J9 ENVIRON MANAGE
JI Environ. Manage.
PD JUN
PY 2016
VL 57
IS 6
BP 1153
EP 1165
DI 10.1007/s00267-016-0684-4
PG 13
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA DK3QG
UT WOS:000374831700002
PM 26961419
ER
PT J
AU Royzar, C
Gillespie, TW
Kawelo, K
AF Royzar, Corey
Gillespie, Thomas W.
Kawelo, Kapua
TI Landscape to site variations in species distribution models for
endangered plants
SO FOREST ECOLOGY AND MANAGEMENT
LA English
DT Article
DE Species distribution model; Dry forest; Endangered species; Restoration;
Hawaii; Oceanic island
ID DRY FOREST RESTORATION; NEW-SOUTH-WALES; CLIMATE-CHANGE; FINE-SCALE;
HABITAT SUITABILITY; SPATIAL SCALES; RARE PLANTS; LAND-COVER;
PREDICTION; PATTERNS
AB Present global plant extinction rates are 100-1000 times greater than pre-human levels and this is especially true on oceanic islands. There is a great need to model the distributions of endangered plants for reintroduction on oceanic islands, however, there are still questions concerning what is the most appropriate spatial scale and which environmental metrics should be included in order to guide restoration efforts. We examine the impact of spatial scale (1 km, 250 m, 10 m), environmental metrics (climate, topography, soils), and species overlap for 11 rare and endangered species in the dry forest of Oahu, Hawaii, which is one of the world's most endangered ecosystems, and contains some of the highest resolution data on species locations and environmental metrics for an oceanic island. At all spatial scales, the species distribution models reliably differentiated between occupied habitat and background for all 11 species (AUC >= 0.92). The relative importance of the environmental metrics did not vary across spatial scales with soil great group contributing most to the models followed by elevation, and mean precipitation of the driest quarter. The percent of the total island area with niche overlap for two or more species did not show any pattern with grain size, however, the 10 m model contained the largest areas of niche overlap for two or more species. There were 1292 10 m pixels on Oahu where models predict niche overlap for eight endangered species, however, only 1.2% of the total area is currently in protected areas. Results suggests that species distribution models are useful for predicting habitat suitability at all scales (1 km, 250 m,10 m), environmental metrics do not change across scales but high resolution data on soils, topography, and precipitation are needed, and 10 m resolution data are the best for informing restoration decisions for the endangered species on Hawaii and other oceanic islands. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Royzar, Corey; Gillespie, Thomas W.] Univ Calif Los Angeles, Dept Geog, Los Angeles, CA 90095 USA.
[Kawelo, Kapua] US Army, Environm Div Directorate Publ Works, Garrison, HI USA.
RP Royzar, C (reprint author), Univ Calif Los Angeles, Dept Geog, Los Angeles, CA 90095 USA.
EM c.rovzar@ucla.edu; tg@geog.ucla.edu; kapua.kawelo@us.army.mil
FU UCLA Department of Geography; Garden Club of America; National Geography
Society
FX This research was funded by the UCLA Department of Geography, Garden
Club of America, and National Geography Society. We thank M. Keir for
field assistance. We also thank T. Giambelluca for providing climate
data and an anonymous reviewer for comments on an earlier draft.
NR 102
TC 0
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U1 16
U2 33
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-1127
EI 1872-7042
J9 FOREST ECOL MANAG
JI For. Ecol. Manage.
PD JUN 1
PY 2016
VL 369
BP 20
EP 28
DI 10.1016/j.foreco.2016.03.030
PG 9
WC Forestry
SC Forestry
GA DK8ID
UT WOS:000375169500003
ER
PT J
AU Galloway, KM
Greathouse, DG
AF Galloway, Kathleen M.
Greathouse, David G.
TI Carpal Tunnel Syndrome in an Adolescent With Obesity
SO PEDIATRIC PHYSICAL THERAPY
LA English
DT Article
DE obesity; female; adolescent; carpal tunnel; human; median nerve; wrist
ID BODY-MASS INDEX; RISK-FACTORS; POPULATION; CHILDHOOD; CHILDREN;
COMPLICATIONS; ASSOCIATIONS; PREVALENCE; THERAPY; DISEASE
AB Purpose: Carpal tunnel syndrome (CTS) is typically found in adults and may be associated with a variety of metabolic conditions including obesity. Obesity is a growing problem among today's youth, and adult diseases often associated with obesity are now being found in a younger population. This case study describes a young adolescent girl with obesity and CTS. Summary of Key Points: A history and examination were completed before electrophysiologic testing, and the patient had no evidence of any contributory pathology. Statement of Conclusions: There was electrophysiologic evidence of bilateral median nerve compromise at the wrist. The patient's diagnosis of CTS may be obesity related. Recommendations for Clinical Practice: Management of patients with obesity and CTS should also include education about weight management in addition to traditional interventions. This may be even more important for a child or adolescent with obesity and CTS.
C1 [Galloway, Kathleen M.] Belmont Univ, Sch Phys Therapy, Nashville, TN USA.
[Galloway, Kathleen M.] Blanchfield Army Community Hosp, Neurol Clin, Ft Campbell, KY USA.
[Greathouse, David G.] Texas Phys Therapy Specialists, Clin Elect Serv, New Braunfels, TX USA.
[Greathouse, David G.] US Army Baylor Univ, Doctoral Program Phys Therapy, Ft Sam Houston, TX USA.
RP Galloway, KM (reprint author), 245 Cherokee Rd, Nashville, TN 37205 USA.
EM Kathy.galloway@belmont.edu
NR 36
TC 0
Z9 0
U1 3
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0898-5669
EI 1538-005X
J9 PEDIATR PHYS THER
JI Pediatr. Phys. Ther.
PD SUM
PY 2016
VL 28
IS 2
BP 248
EP 252
DI 10.1097/PEP.0000000000000236
PG 5
WC Pediatrics; Rehabilitation
SC Pediatrics; Rehabilitation
GA DI5JT
UT WOS:000373535400027
PM 26963876
ER
PT J
AU Hu, X
Compton, JR
Leary, DH
Olson, MA
Lee, MS
Cheung, J
Ye, W
Ferrer, M
Southall, N
Jadhav, A
Morazzani, EM
Glass, PJ
Marugan, J
Legler, PM
AF Hu, Xin
Compton, Jaimee R.
Leary, Dagmar H.
Olson, Mark A.
Lee, Michael S.
Cheung, Jonah
Ye, Wenjuan
Ferrer, Mark
Southall, Noel
Jadhav, Ajit
Morazzani, Elaine M.
Glass, Pamela J.
Marugan, Juan
Legler, Patricia M.
TI Kinetic, Mutational, and Structural Studies of the Venezuelan Equine
Encephalitis Virus Nonstructural Protein 2 Cysteine Protease
SO BIOCHEMISTRY
LA English
DT Article
ID PAPAIN-LIKE PROTEASE; CRYSTAL-STRUCTURE; SINDBIS-VIRUS; CATHEPSIN-B;
NONCYTOPATHIC REPLICATION; RECOMBINANT PROTEINS; ESCHERICHIA-COLI;
TRANSITION-STATE; MAMMALIAN-CELLS; NSP2 PROTEASE
AB The Venezuelan equine encephalitis virus (VEEV) nonstructural protein 2 (nsP2) cysteine protease (EC 3.4.22.-) is essential for viral replication and is involved in the cytopathic effects (CPE) of the virus. The VEEV nsP2 protease is a member of MEROPS Clan CN and characteristically contains a papain-like protease linked to an S-adenosyl-L-methionine-dependent RNA methyltransferase (SAM MTase) domain. The protease contains an alternative active site motif, (475)NVCWAK(480), which differs from papain's (CGS(25)CWAFS), and the enzyme lacks a transition state-stabilizing residue homologous to GIn-19 in papain. To understand the roles of conserved residues in catalysis, we determined the structure of the free enzyme and the first structure of an inhibitor-bound alphaviral protease. The peptide-like E64d inhibitor was found to bind beneath a beta-hairpin at the interface of the SAM MTase and protease domains. His-546 adopted a conformation that differed from that found in the free enzyme; one or both of the conformers may assist in leaving group departure of either the amine or Cys thiolate during the catalytic cycle. Interestingly, E64c (200 mu M), the carboxylic acid form of the E64d ester, did not inhibit the nsP2 protease. To identify key residues involved in substrate binding, a number of mutants were analyzed. Mutation of the motif residue, N475A, led to a 24 fold reduction in k(cat)/K-m, and the conformation of this residue did not change after inhibition. N475 forms a hydrogen bond with R662 in the SAM MTase domain, and the R662A and R662K mutations both led to 16-fold decreases in k(cat)/K-m. N475 forms the base of the P1 binding site and likely orients the substrate for nucleophilic attack or plays a role in product release. An Asn homologous to N475 is similarly found in coronaviral papain-like proteases (PLpro) of the Severe Acute Respiratory Syndrome (SARS) virus and Middle East Respiratory Syndrome (MERS) virus. Mutation of another motif residue, K480A, led to a 9-fold decrease in k(cat) and k(cat)/K-m. K480 likely enhances the nucleophilicity of the Cys. Consistent with our substrate-bound models, the SAM MTase domain K706A mutation increased K-m 4.5-fold to 500 mu M. Within the beta-hairpin, the N545A mutation slightly but not significantly increased k(cat) and K-m. The structures and identified active site residues may facilitate the discovery of protease inhibitors with antiviral activity.
C1 [Hu, Xin; Ye, Wenjuan; Ferrer, Mark; Southall, Noel; Jadhav, Ajit; Marugan, Juan] NIH, Chem Genom Ctr, Natl Ctr Adv Translat Sci, Rockville, MD 20850 USA.
[Compton, Jaimee R.] Nova Res Inc, Alexandria, VA 22308 USA.
[Cheung, Jonah] New York Struct Biol Ctr, New York, NY 10027 USA.
[Olson, Mark A.; Lee, Michael S.; Morazzani, Elaine M.; Glass, Pamela J.] US Army, Med Res Inst Infect Dis, Frederick, MD 21702 USA.
[Legler, Patricia M.] US Navy, Res Lab, Ctr Biomol Sci & Engn, Washington, DC 20375 USA.
RP Legler, PM (reprint author), US Navy, Res Lab, Ctr Biomol Sci & Engn, Washington, DC 20375 USA.
EM patricialegler@nrl.navy.mil
FU DTRA [CB-SEED-SEED09-2-0061, CBCall4-CBM-05-2-0019]
FX This work was supported by DTRA Projects CB-SEED-SEED09-2-0061 and
CBCall4-CBM-05-2-0019.
NR 75
TC 1
Z9 1
U1 0
U2 3
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0006-2960
J9 BIOCHEMISTRY-US
JI Biochemistry
PD MAY 31
PY 2016
VL 55
IS 21
BP 3007
EP 3019
DI 10.1021/acs.biochem.5b00992
PG 13
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA DN5ZT
UT WOS:000377151100011
PM 27030368
ER
PT J
AU Vurgaftman, I
Belenky, G
Lin, Y
Donetsky, D
Shterengas, L
Kipshidze, G
Sarney, WL
Svensson, SP
AF Vurgaftman, I.
Belenky, G.
Lin, Y.
Donetsky, D.
Shterengas, L.
Kipshidze, G.
Sarney, W. L.
Svensson, S. P.
TI Interband absorption strength in long-wave infrared type-II
superlattices with small and large superlattice periods compared to bulk
materials
SO APPLIED PHYSICS LETTERS
LA English
DT Article
ID STRAINED-LAYER SUPERLATTICES; THIN-FILMS; PHOTODIODES; ALLOYS
AB The absorption spectra for the antimonide-based type-II superlattices (SLs) for detection in the long-wave infrared (LWIR) are calculated and compared to the measured data for SLs and bulk materials with the same energy gap (HgCdTe and InAsSb). We include the results for the metamorphic InAsSbx/InAsSby SLs with small periods as well as the more conventional strain-balanced InAs/Ga(In)Sb and InAs/InAsSb SLs on GaSb substrates. The absorption strength in small-period metamorphic SLs is similar to the bulk materials, while the SLs with an average lattice constant matched to GaSb have significantly lower absorption. This is because the electron-hole overlap in the strain-balanced type-II LWIR SLs occurs primarily in the hole well, which constitutes a relatively small fraction of the total thickness. Published by AIP Publishing.
C1 [Vurgaftman, I.] Naval Res Lab, Code 5613, Washington, DC 20375 USA.
[Belenky, G.; Lin, Y.; Donetsky, D.; Shterengas, L.; Kipshidze, G.] SUNY Stony Brook, Stony Brook, NY 11794 USA.
[Sarney, W. L.; Svensson, S. P.] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
RP Belenky, G (reprint author), SUNY Stony Brook, Stony Brook, NY 11794 USA.
EM gregory.belenky@stonybrook.edu
OI LIN, YOUXI/0000-0002-9092-2302
FU U.S. Army Research Office [W911NF-16-2-0053]; U.S. National Science
Foundation [DMR1160843]
FX This work was supported by U.S. Army Research Office through Grant No.
W911NF-16-2-0053 and by U.S. National Science Foundation through Grant
No. DMR1160843. We acknowledge the valuable suggestions of Dr. Jerry
Meyer, Dr. Serge Luryi, and Dr. Sergey Suchalkin.
NR 21
TC 2
Z9 2
U1 16
U2 26
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0003-6951
EI 1077-3118
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD MAY 30
PY 2016
VL 108
IS 22
AR 222101
DI 10.1063/1.4953035
PG 5
WC Physics, Applied
SC Physics
GA DP3XE
UT WOS:000378428400020
ER
PT J
AU Lai, CW
Schwab, M
Hill, SC
Santarpia, J
Pan, YL
AF Lai, Chih Wei
Schwab, Mark
Hill, Steven C.
Santarpia, Joshua
Pan, Yong-Le
TI Raman scattering and red fluorescence in the photochemical
transformation of dry tryptophan particles
SO OPTICS EXPRESS
LA English
DT Article
ID AROMATIC-AMINO-ACIDS; EXCITED-STATE CHEMISTRY; AIRBORNE BIOLOGICAL
PARTICLES; PROTEIN SECONDARY STRUCTURE; EXCITATION PROFILES;
SIDE-CHAINS; TYROSINE; SPECTROSCOPY; PEPTIDES; SPECTRA
AB Tryptophan is a fluorescent amino acid common in proteins. Its absorption is largest for wavelengths lambda less than or similar to 290 nm and its fluorescence emissions peak around 300-350 nm, depending upon the local environment. Here we report the observation of red fluorescence near 600 nm emerging from 488-nm continuous-wave (CW) laser photoexcitation of dry tryptophan (Trp) particles. With an excitation intensity below 0.5 kW/cm(2), dry Trp particles yield distinctive Raman scattering peaks in the presence of relatively weak and spectrally broad emissions with lambda similar to 500-700 nm, allowing estimation of particle temperature at low excitation intensities. When the photoexcitation intensity is increased to 1 kW/cm(2) or more for a few minutes, fluorescence intensity dramatically increases by more than two orders of magnitude. The fluorescence continues to increase in intensity and gradually shift to the red when photoexcitation intensity and the duration of exposure are increased. The resulting products absorb at visible wavelengths and generate red fluorescence with lambda similar to 650-800 nm with 633-nm CW laser excitation. We attribute the emergence of orange and red fluorescence in the Trp products to a photochemical transformation that is instigated by weak optical transitions to triplet states in Trp with 488-nm excitation and which may be expedited by a photothermal effect. (C) 2016 Optical Society of America
C1 [Lai, Chih Wei; Schwab, Mark; Hill, Steven C.; Pan, Yong-Le] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
[Lai, Chih Wei] Michigan State Univ, Dept Phys & Astron, E Lansing, MI 48824 USA.
[Santarpia, Joshua] Sandia Natl Labs, Albuquerque, NM 87123 USA.
RP Lai, CW (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.; Lai, CW (reprint author), Michigan State Univ, Dept Phys & Astron, E Lansing, MI 48824 USA.
EM cwlai@msu.edu
RI Lai, Chih Wei/E-4945-2010
OI Lai, Chih Wei/0000-0003-3571-4671
FU Defense Threat Reduction Agency (DTRA) [HDTRS1518237, HDTRA1619734];
U.S. Army Research Laboratory (ARL) mission funds; National Science
Foundation (NSF) under NSF grant [DMR-0955944]; Army Research Laboratory
[W911NF-12-2-0019]
FX We thank Shouwen Hu for technical support. This work was supported by
the Defense Threat Reduction Agency (DTRA) under HDTRS1518237 and
HDTRA1619734 as well as the U.S. Army Research Laboratory (ARL) mission
funds. Research conducted by C.W.L. was partly sponsored by the National
Science Foundation (NSF) under the NSF grant DMR-0955944. Research was
sponsored by the Army Research Laboratory and was accomplished under
Cooperative Agreement Number W911NF-12-2-0019. The views and conclusions
contained in this document are those of the authors and should not be
interpreted as representing the official policies, either expressed or
implied, of the Army Research Laboratory or the U.S. Government. The
U.S. Government is authorized to reproduce and distribute reprints for
Government purposes notwithstanding any copyright notation herein.
NR 46
TC 0
Z9 0
U1 6
U2 12
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 1094-4087
J9 OPT EXPRESS
JI Opt. Express
PD MAY 30
PY 2016
VL 24
IS 11
BP 1654
EP 1667
DI 10.1364/OE.24.011654
PG 14
WC Optics
SC Optics
GA DO0KM
UT WOS:000377467800033
PM 27410091
ER
PT J
AU Ivashchenko, VI
Turchi, PEA
Veprek, S
Shevchenko, VI
Leszczynski, J
Gorb, L
Hill, F
AF Ivashchenko, V. I.
Turchi, P. E. A.
Veprek, S.
Shevchenko, V. I.
Leszczynski, Jerzy
Gorb, Leonid
Hill, Frances
TI First-principles study of crystalline and amorphous AlMgB14-based
materials
SO JOURNAL OF APPLIED PHYSICS
LA English
DT Article
ID 1ST PRINCIPLES; THIN-FILMS; BORON; BORIDES; DIFFRACTION
AB We report first-principles investigations of crystalline and amorphous boron and M1(x)M2(y)X(z)B(14-z) (M1, M2 = Al, Mg, Li, Na, Y; X = Ti, C, Si) phases (so-called "BAM" materials). Phase stability is analyzed in terms of formation energy and dynamical stability. The atomic configurations as well as the electronic and phonon density states of these phases are compared. Amorphous boron consists of distorted icosahedra, icosahedron fragments, and dioctahedra, connected by an amorphous network. The presence of metal atoms in amorphous BAM materials precludes the formation of icosahedra. For all the amorphous structures considered here, the Fermi level is located in the mobility gap independent of the number of valence electrons. The intra-icosahedral vibrations are localized in the range of 800 cm(-1), whereas the inter-icosahedral vibrations appear at higher wavenumbers. The amorphization leads to an enhancement of the vibrations in the range of 1100-1250 cm(-1). The mechanical properties of BAM materials are investigated at equilibrium and under shear and tensile strain. The anisotropy of the ideal shear and tensile strengths is explained in terms of a layered structure of the B-12 units. The strength of amorphous BAM materials is lower than that of the crystalline counterparts because of the partial fragmentation of the boron icosahedra in amorphous structures. The strength enhancement found experimentally for amorphous boron-based films is very likely related to an increase in film density, and the presence of oxygen impurities. For crystalline BAM materials, the icosahedra are preserved during elongation upon tension as well as upon shear in the (010)[100] slip system. Published by AIP Publishing.
C1 [Ivashchenko, V. I.; Shevchenko, V. I.] Natl Acad Sci Ukraine, Inst Problems Mat Sci, Krzhyzhanosky Str 3, UA-03142 Kiev, Ukraine.
[Turchi, P. E. A.] Lawrence Livermore Natl Lab, L-352,POB 808, Livermore, CA 94551 USA.
[Veprek, S.] Tech Univ Munich, Dept Chem, Lichtenbergstr 4, D-85747 Garching, Germany.
[Leszczynski, Jerzy; Gorb, Leonid] Jackson State Univ, Dept Chem & Biochem, Interdisciplinary Ctr Nanotox, Jackson, MS 39217 USA.
[Gorb, Leonid] Badger Tech Serv LLC, Vicksburg, MS 39180 USA.
[Hill, Frances] US Army, Erdc, Vicksburg, MS 39180 USA.
RP Shevchenko, VI (reprint author), Natl Acad Sci Ukraine, Inst Problems Mat Sci, Krzhyzhanosky Str 3, UA-03142 Kiev, Ukraine.
EM shev@materials.kiev.ua
RI Veprek, Stan/C-1248-2008
OI Veprek, Stan/0000-0002-6016-3093
FU STCU [5964]; U.S. Department of Energy by the Lawrence Livermore
National Laboratory [DE-AC52-07NA27344]; Company SHM s.r.o. (Czech
Republic)
FX This work was supported by the STCU Contract No. 5964. The work of P.T.
was performed under the auspices of the U.S. Department of Energy by the
Lawrence Livermore National Laboratory under Contract No.
DE-AC52-07NA27344. The authors are grateful to the directorate of the
Summer Institute at Jackson State University for the opportunity to
perform large-scale calculations. S.V. thanks the Company SHM s.r.o.
(Czech Republic) for financial support. We also thank Dr. M.G.J.
Veprek-Heijman for critical reading of the manuscript and many useful
comments.
NR 48
TC 1
Z9 1
U1 4
U2 15
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0021-8979
EI 1089-7550
J9 J APPL PHYS
JI J. Appl. Phys.
PD MAY 28
PY 2016
VL 119
IS 20
AR 205105
DI 10.1063/1.4952391
PG 13
WC Physics, Applied
SC Physics
GA DO3YM
UT WOS:000377718700037
ER
PT J
AU Chaudhury, S
Ockenhouse, CF
Regules, JA
Dutta, S
Wallqvist, A
Jongert, E
Waters, NC
Lemiale, F
Bergmann-Leitner, E
AF Chaudhury, Sidhartha
Ockenhouse, Christian F.
Regules, Jason A.
Dutta, Sheetij
Wallqvist, Anders
Jongert, Erik
Waters, Norman C.
Lemiale, Franck
Bergmann-Leitner, Elke
TI The biological function of antibodies induced by the RTS,S/AS01 malaria
vaccine candidate is determined by their fine specificity
SO MALARIA JOURNAL
LA English
DT Article
DE Malaria; Antibody; Phagocytosis; Epitope; Protection
ID FALCIPARUM CIRCUMSPOROZOITE PROTEIN; C-TERMINAL FRAGMENT;
PLASMODIUM-BERGHEI; IMMUNE-RESPONSE; LEISHMANIA PARASITES; PROTECTIVE
RESPONSE; NAIVE ADULTS; DOUBLE-BLIND; EFFICACY; CELL
AB Background: Recent vaccine studies have shown that the magnitude of an antibody response is often insufficient to explain efficacy, suggesting that characteristics regarding the quality of the antibody response, such as its fine specificity and functional activity, may play a major role in protection. Previous studies of the lead malaria vaccine candidate, RTS,S, have shown that circumsporozoite protein (CSP)-specific antibodies and CD4(+) T cell responses are associated with protection, however the role of fine specificity and biological function of CSP-specific antibodies remains to be elucidated. Here, the relationship between fine specificity, opsonization-dependent phagocytic activity and protection in RTS, S-induced antibodies is explored.
Methods: A new method for measuring the phagocytic activity mediated by CSP-specific antibodies in THP-1 cells is presented and applied to samples from a recently completed phase 2 RTS,S/AS01 clinical trial. The fine specificity of the antibody response was assessed using ELISA against three antigen constructs of CSP: the central repeat region, the C-terminal domain and the full-length protein. A multi-parameter analysis of phagocytic activity and fine-specificity data was carried out to identify potential correlates of protection in RTS, S.
Results: Results from the newly developed assay revealed that serum samples from RTS, S recipients displayed a wide range of robust and repeatable phagocytic activity. Phagocytic activity was correlated with full-length CSP and C-terminal specific antibody titres, but not to repeat region antibody titres, suggesting that phagocytic activity is primarily driven by C-terminal antibodies. Although no significant difference in overall phagocytic activity was observed with respect to protection, phagocytic activity expressed as 'opsonization index', a relative measure that normalizes phagocytic activity with CS antibody titres, was found to be significantly lower in protected subjects than non-protected subjects.
Conclusions: Opsonization index was identified as a surrogate marker of protection induced by the RTS,S/AS01 vaccine and determined how antibody fine specificity is linked to opsonization activity. These findings suggest that the role of opsonization in protection in the RTS, S vaccine may be more complex than previously thought, and demonstrate how integrating multiple immune measures can provide insight into underlying mechanisms of immunity and protection.
C1 [Chaudhury, Sidhartha; Wallqvist, Anders] US Army Med Res & Mat Command, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA.
[Ockenhouse, Christian F.; Lemiale, Franck] PATH Malaria Vaccine Initiat, Washington, DC USA.
[Regules, Jason A.] US Army, Dept Clin Res, Med Res Inst Infect Dis, Ft Detrick, MD USA.
[Dutta, Sheetij; Waters, Norman C.; Bergmann-Leitner, Elke] Walter Reed Army Inst Res, Malaria Vaccine Branch, US Mil Malaria Res Program, 503 Robert Grant Ave,3W53, Silver Spring, MD 20910 USA.
[Jongert, Erik] GSK Vaccine, Rixensart, Belgium.
RP Bergmann-Leitner, E (reprint author), Walter Reed Army Inst Res, Malaria Vaccine Branch, US Mil Malaria Res Program, 503 Robert Grant Ave,3W53, Silver Spring, MD 20910 USA.
EM elke.s.bergmannleitner.civ@mail.mil
FU PATH Malaria Vaccine Initiative
FX We would like to thank Ms. Tanisha Robinson and Ms. Lisa Dlugosz for
technical assistance and Dominique Wauters (GSK Vaccines) for his input
into the scope of work. The opinions and assertions contained herein are
the private views of the authors and are not to be construed as official
or as reflecting the views of the US Army or the US Department of
Defense. This paper has been approved for public release with unlimited
distribution. Funding for this study was provided by PATH Malaria
Vaccine Initiative.
NR 35
TC 0
Z9 0
U1 7
U2 10
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2875
J9 MALARIA J
JI Malar. J.
PD MAY 28
PY 2016
VL 15
AR 301
DI 10.1186/s12936-016-1348-9
PG 12
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA DN6JN
UT WOS:000377180200004
PM 27245446
ER
PT J
AU Dodds, SG
Livi, CB
Parihar, M
Hsu, HK
Benavides, AD
Morris, J
Javors, M
Strong, R
Christy, B
Hasty, P
Sharp, ZD
AF Dodds, Sherry G.
Livi, Carolina B.
Parihar, Manish
Hsu, Hang-Kai
Benavides, Adriana D.
Morris, Jay
Javors, Martin
Strong, Randy
Christy, Barbara
Hasty, Paul
Sharp, Zelton Dave
TI Adaptations to chronic rapamycin in mice
SO PATHOBIOLOGY OF AGING AND AGE-RELATED DISEASES
LA English
DT Article
DE mTORC1; rapamycin; translation; ribosome biogenesis
ID EXTENDS LIFE-SPAN; GENETICALLY HETEROGENEOUS MICE; INITIATION-FACTOR 4E;
EIF4E/4E-BP RATIO; MAMMALIAN TARGET; MTOR; INHIBITION; CANCER; EIF4E;
PHOSPHORYLATION
AB Rapamycin inhibits mechanistic (or mammalian) target of rapamycin (mTOR) that promotes protein production in cells by facilitating ribosome biogenesis (RiBi) and eIF4E-mediated 5'cap mRNA translation. Chronic treatment with encapsulated rapamycin (eRapa) extended health and life span for wild-type and cancer-prone mice. Yet, the long-term consequences of chronic eRapa treatment are not known at the organ level. Here, we report our observations of chronic eRapa treatment on mTORC1 signaling and RiBi in mouse colon and visceral adipose. As expected, chronic eRapa treatment decreased detection of phosphorylated mTORC1/S6K substrate, ribosomal protein (rpS6) in colon and fat. However, in colon, contrary to expectations, there was an upregulation of 18S rRNA and some ribosomal protein genes (RPGs) suggesting increased RiBi. Among RPGs, eRapa increases rpl22l1 mRNA but not its paralog rpl22. Furthermore, there was an increase in the cap-binding protein, eIF4E relative to its repressor 4E-BP1 suggesting increased translation. By comparison, in fat, there was a decrease in the level of 18S rRNA (opposite to colon), while overall mRNAs encoding ribosomal protein genes appeared to increase, including rpl22, but not rpl22l1 (opposite to colon). In fat, there was a decrease in eIF4E relative to actin (opposite to colon) but also an increase in the eIF4E/4E-BP1 ratio likely due to reductions in 4E-BP1 at our lower eRapa dose (similar to colon). Thus, in contrast to predictions of decreased protein production seen in cell-based studies, we provide evidence that colon from chronically treated mice exhibited an adaptive 'pseudo-anabolic' state, which is only partially present in fat, which might relate to differing tissue levels of rapamycin, cell-type-specific responses, and/or strain differences.
C1 [Dodds, Sherry G.; Livi, Carolina B.; Parihar, Manish; Hsu, Hang-Kai; Morris, Jay; Christy, Barbara; Hasty, Paul; Sharp, Zelton Dave] Univ Texas Hlth Sci Ctr San Antonio, Inst Biotechnol, Dept Mol Med, San Antonio, TX 78229 USA.
[Livi, Carolina B.] Agilent Technol, Santa Clara, CA USA.
[Hsu, Hang-Kai] City Hope Natl Med Ctr, KCRB 2018, 1500 E Duarte Rd, Duarte, CA 91010 USA.
[Benavides, Adriana D.] Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol & Immunol, San Antonio, TX 78229 USA.
[Benavides, Adriana D.] Childrens Hosp Philadelphia, Infect Dis Res Div, Philadelphia, PA 19104 USA.
[Javors, Martin] Univ Texas Hlth Sci Ctr San Antonio, Dept Psychiat, San Antonio, TX 78229 USA.
[Javors, Martin; Strong, Randy] Univ Texas Hlth Sci Ctr San Antonio, Dept Pharmacol, San Antonio, TX 78229 USA.
[Strong, Randy; Hasty, Paul; Sharp, Zelton Dave] Univ Texas Hlth Sci Ctr San Antonio, Barshop Inst Longev & Aging Studies, San Antonio, TX 78229 USA.
[Strong, Randy] South Texas Vet Hlth Care Syst, Geriatr Res Educ & Clin Ctr, San Antonio, TX USA.
[Christy, Barbara] US Army Inst Surg Res, Coagulat & Blood Res Grp, JBSA Ft Sam Houston, TX USA.
[Hasty, Paul; Sharp, Zelton Dave] Canc Therapy & Res Ctr S Texas, 4450 Med Dr, San Antonio, TX 78229 USA.
RP Hasty, P; Sharp, ZD (reprint author), Dept Mol Med, 15355 Lambda Dr, San Antonio, TX 78245 USA.
EM hastye@uthscsa.edu; sharp@uthscsa.edu
FU NCI NIH HHS [R01 CA193835]; NIA NIH HHS [P30 AG013319, U01 AG022307]
NR 59
TC 2
Z9 2
U1 1
U2 1
PU CO-ACTION PUBLISHING
PI JARFALLA
PA RIPVAGEN 7, JARFALLA, SE-175 64, SWEDEN
EI 2001-0001
J9 PATHOBIOL AGING AGE
JI Pathobiol. Aging Age-relat. Dis.
PD MAY 27
PY 2016
VL 6
AR 31688
DI 10.3402/pba.v6.31688
PG 11
WC Pathology
SC Pathology
GA DT4ET
UT WOS:000381433600001
PM 27237224
ER
PT J
AU Su, J
Felton, M
Lei, LQ
McCormick, MP
Delgado, R
Pe, AS
AF Su, Jia
Felton, Melvin
Lei, Liqiao
McCormick, M. Patrick
Delgado, Ruben
Pe, Alexandra St.
TI Lidar remote sensing of cloud formation caused by low-level jets
SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES
LA English
DT Article
ID SOUTHERN GREAT-PLAINS; BOUNDARY-LAYER; JOHNSTOWN FLOOD; CLIMATOLOGY;
SITE
AB In May 2014, the East Hampton Roads Aerosol Flux campaign was conducted at Hampton University to examine small-scale aerosol transport using aerosol, Raman, and Doppler lidars and rawindsonde launches. We present the results of analyses performed on these high-resolution planetary boundary layer and lower atmospheric measurements, with a focus on the low-level jets (LLJs) that form in this region during spring and summer. We present a detailed case study of a LLJ lasting from evening of 20 May to morning of 21 May using vertical profiles of aerosol backscatter, wind speed and direction, water vapor mixing ratio, temperature, and turbulence structure. We show with higher resolution than in previous studies that enhanced nighttime turbulence triggered by LLJs can cause the aerosol and water vapor content of the boundary layer to be transported vertically and form a well-mixed region containing the cloud condensation nuclei that are necessary for cloud formation.
C1 [Su, Jia; Lei, Liqiao; McCormick, M. Patrick] Hampton Univ, Dept Atmospher & Planetary Sci, Ctr Atmospher Sci, Hampton, VA 23668 USA.
[Felton, Melvin] US Army Res Lab, Adelphi, MD 20783 USA.
[Delgado, Ruben; Pe, Alexandra St.] Univ Maryland Baltimore Cty, Joint Ctr Earth Syst Technol, Baltimore, MD 21228 USA.
RP Felton, M (reprint author), US Army Res Lab, Adelphi, MD 20783 USA.
EM melvin.a.felton.civ@mail.mil
RI Delgado, Ruben/F-9753-2016
OI Delgado, Ruben/0000-0002-7133-2462
FU Partnership in Research and Transition cooperative agreement - U.S. Army
Research Office [551150-211150]
FX This research was supported by the Partnership in Research and
Transition cooperative agreement funded by the U.S. Army Research
Office, award 551150-211150. The paper data are from this link
(http://sol.hamptonu.edu/hu-lidar/hu-lidar-data-products/).
NR 28
TC 0
Z9 0
U1 4
U2 4
PU AMER GEOPHYSICAL UNION
PI WASHINGTON
PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA
SN 2169-897X
EI 2169-8996
J9 J GEOPHYS RES-ATMOS
JI J. Geophys. Res.-Atmos.
PD MAY 27
PY 2016
VL 121
IS 10
BP 5904
EP 5911
DI 10.1002/2015JD024590
PG 8
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA DT6YB
UT WOS:000381629900047
ER
PT J
AU Gupta, P
Sharma, A
Spurgers, KB
Bakken, RR
Eccleston, LT
Cohen, JW
Honnold, SP
Glass, PJ
Maheshwari, RK
AF Gupta, Paridhi
Sharma, Anuj
Spurgers, Kevin B.
Bakken, Russell R.
Eccleston, Lori T.
Cohen, Jeffrey W.
Honnold, Shelley P.
Glass, Pamela J.
Maheshwari, Radha K.
TI 1,5-Iodonaphthyl azide-inactivated V3526 protects against aerosol
challenge with virulent venezuelan equine encephalitis virus
SO VACCINE
LA English
DT Article
DE Venezuelan equine encephalitis; Vaccine; Inactivated; Iodonaphthyl
azide; Aerosol challenge; Protection
ID STRUCTURAL INTEGRITY; NONHUMAN-PRIMATES; PRESERVATION; VACCINES;
INFECTION; RESPONSES; ANTIBODY; VEEV
AB Venezuelan equine encephalitis virus (VEEV) is a New World alphavirus. VEEV is highly infectious in aerosolized form and has been identified as a bio-terrorism agent. There is no licensed vaccine for prophylaxis against VEEV. The current IND vaccine is poorly immunogenic and does not protect against an aerosol challenge with virulent VEEV. We have previously shown that VEEV inactivated by 1,5-iodonaphthyl azide (INA) protects against footpad challenge with virulent VEEV. In this study, we inactivated an attenuated strain of VEEV, V3526, with INA and evaluated its protective efficacy against aerosol challenge with wild type VEEV. We demonstrated that among three routes of immunization, intramuscular immunization with INA-inactivate V3526 (INA-iV3526) provided complete protection against aerosol challenge with virulent VEEV. Our data suggests that INA-iV3526 can be explored further for development as an effective vaccine candidate against aerosol challenge of virulent VEEV. (C) 2016 Published by Elsevier Ltd.
C1 [Gupta, Paridhi; Sharma, Anuj; Maheshwari, Radha K.] Uniformed Serv Univ Hlth Sci, Dept Pathol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
[Spurgers, Kevin B.; Bakken, Russell R.; Eccleston, Lori T.; Cohen, Jeffrey W.; Honnold, Shelley P.; Glass, Pamela J.] US Army, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA.
RP Sharma, A (reprint author), 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
EM anuj.sharma.ctr@usuhs.edu
FU Defense Threat Reduction Agency
FX This work was supported by a grant from Defense Threat Reduction Agency.
The opinions expressed herein are of those of the author(s) and are not
necessarily representative of those of the Uniformed Services University
of the Health Sciences (USUHS), USAMRIID, the Department of Defense
(DoD); or, the United States Army, Navy, or Air Force.
NR 20
TC 0
Z9 0
U1 1
U2 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
EI 1873-2518
J9 VACCINE
JI Vaccine
PD MAY 27
PY 2016
VL 34
IS 25
BP 2762
EP 2765
DI 10.1016/j.vaccine.2016.04.049
PG 4
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA DN8GQ
UT WOS:000377317600002
PM 27129427
ER
PT J
AU Ben Salem, H
Damarla, T
Sudusinghe, K
Stechele, W
Bhattacharyya, SS
AF Ben Salem, Haifa
Damarla, Thyagaraju
Sudusinghe, Kishan
Stechele, Walter
Bhattacharyya, Shuvra S.
TI Adaptive tracking of people and vehicles using mobile platforms
SO EURASIP JOURNAL ON ADVANCES IN SIGNAL PROCESSING
LA English
DT Article
DE Acoustic sensors; Dataflow graphs; DDDAS; Mobile platforms; Signal
processing systems; Target tracking
ID CLASSIFICATION
AB Tracking algorithms have important applications in detection of humans and vehicles for border security and other areas. For large-scale deployment of such algorithms, it is critical to provide methods for their cost- and energy-efficient realization. To this end, commodity mobile devices have significant potential for use as prototyping and testing platforms due to their low cost, widespread availability, and integration of advanced communications, sensing, and processing features. Prototypes developed on mobile platforms can be tested, fine-tuned, and demonstrated in the field and then provide reference implementations for application-specific disposable sensor node implementations that are targeted for deployment. In this paper, we develop a novel, adaptive tracking system that is optimized for energy-efficient, real-time operation on off-the-shelf mobile platforms. Our tracking system applies principles of dynamic data-driven application systems (DDDAS) to periodically monitor system operating characteristics and apply these measurements to dynamically adapt the specific classifier configurations that the system employs. Our resulting adaptive approach enables powerful optimization of trade-offs among energy consumption, real-time performance, and tracking accuracy based on time-varying changes in operational characteristics. Through experiments employing an Android-based tablet platform, we demonstrate the efficiency of our proposed tracking system design for multimode detection of human and vehicle targets.
C1 [Ben Salem, Haifa; Sudusinghe, Kishan; Bhattacharyya, Shuvra S.] Univ Maryland, College Pk, MD 20742 USA.
[Damarla, Thyagaraju] US Army Res Lab, Army Res Lab, Adelphi, MD USA.
[Stechele, Walter] Tech Univ Munich, Inst Integrated Syst, D-80290 Munich, Germany.
[Bhattacharyya, Shuvra S.] Tampere Univ Technol, FIN-33101 Tampere, Finland.
RP Ben Salem, H (reprint author), Univ Maryland, College Pk, MD 20742 USA.
EM haifa.ben-salem@tum.de
NR 25
TC 0
Z9 0
U1 5
U2 9
PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 1687-6180
J9 EURASIP J ADV SIG PR
JI EURASIP J. Adv. Signal Process.
PD MAY 26
PY 2016
AR 65
DI 10.1186/s13634-016-0356-9
PG 12
WC Engineering, Electrical & Electronic
SC Engineering
GA DN3YG
UT WOS:000376999600001
ER
PT J
AU Neupane, MR
Garrett, GA
Rudin, S
Andzelm, JW
AF Neupane, M. R.
Garrett, G. A.
Rudin, S.
Andzelm, J. W.
TI Phase dependent structural and electronic properties of lanthanum
orthophosphate (LaPO4)
SO JOURNAL OF PHYSICS-CONDENSED MATTER
LA English
DT Article
DE lanthanum; rare-earth; hybrid functionals; PBE; energy gap
ID BRILLOUIN-ZONE INTEGRATIONS; RARE-EARTH ORTHOPHOSPHATES; INITIO
MOLECULAR-DYNAMICS; TOTAL-ENERGY CALCULATIONS; WAVE BASIS-SET;
OPTICAL-PROPERTIES; EFFECTIVE-MASS; DOPED LAPO4; NANOCRYSTALS; NANORODS
AB We study the phase-dependent structural and electronic properties of bulk LaPO4, using density functional theory (DFT). The applicability of conventional semi-local and hybrid functionals in predicting structural and electronic properties of monoclinic and hexagonal LaPO4 is evaluated by comparing results to available experimental data. The monoclinic LaPO4 was found to be more stable than the hexagonal phase in ambient conditions with a small energy difference, suggesting a possibility of a phase transition. Both the phases in the bulk form are found to be diamagnetic with indirect energy gaps. These results are consistent with available experimental results. In the monoclinic phase, the hybrid functionals predict indirect band gap at about 8 eV. Furthermore, the calculated indirect-direct transition energy offset (Delta E) in the hexagonal phase was three times lower than the monoclinic phase. Our calculations based on hybrid functionals also reveal that the states near the conduction band edge in the hexagonal LaPO4 are strongly hybridized between La and PO4 states. By analyzing the band dispersion around the band edges, we show that the hexagonal phase has lighter electron effective mass, as compared to the monoclinic phase. With a larger energy gap, smaller Delta E, and smaller electron effective mass, the hexagonal LaPO4 might be a promising candidate material as an n-type transparent oxide.
C1 [Neupane, M. R.; Andzelm, J. W.] US Army Res Lab, RDRL WMM G, 4600 Aberdeen Proving Ground, Aberdeen, MD 21005 USA.
[Garrett, G. A.; Rudin, S.] US Army Res Lab, RDRL SEE M, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
RP Neupane, MR; Andzelm, JW (reprint author), US Army Res Lab, RDRL WMM G, 4600 Aberdeen Proving Ground, Aberdeen, MD 21005 USA.
EM mahesh.neupane.ctr@mail.mil; jan.w.andzelm.civ@mail.mil
FU DOD High Performance Computing Modernization Program at the U.S. Air
Force Research Laboratory; U.S. Army Engineer Research and Development
Center DoD Supercomputing Resource Centers
FX We acknowledge helpful discussions with Dr Tanya L Chantawansri and Dr
Krista Limmer. MRN was supported by an appointment to the Postgraduate
Research Participation Program at the U.S. Army Research Laboratory
administered by the Oak Ridge Institute for Science and Education
through an interagency agreement between the U.S. Department of Energy
and USARL. This work was supported by grants of computer time from the
DOD High Performance Computing Modernization Program at the U.S. Air
Force Research Laboratory and U.S. Army Engineer Research and
Development Center DoD Supercomputing Resource Centers.
NR 60
TC 1
Z9 1
U1 6
U2 8
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0953-8984
EI 1361-648X
J9 J PHYS-CONDENS MAT
JI J. Phys.-Condes. Matter
PD MAY 25
PY 2016
VL 28
IS 20
AR 205501
DI 10.1088/0953-8984/28/20/205501
PG 10
WC Physics, Condensed Matter
SC Physics
GA DM5RZ
UT WOS:000376409000005
PM 27114454
ER
PT J
AU Rao, P
Hromadka, TV
AF Rao, Prasada
Hromadka, Theodore V., II
TI Numerical modeling of rapidly varying flows using HEC-RAS and WSPG
models
SO SPRINGERPLUS
LA English
DT Article
DE Open channel; Roughness; Hydraulic jump; Froude number
ID HYDRAULIC JUMP; SIMULATION; EQUATIONS; SCHEMES
AB The performance of two popular hydraulic models (HEC-RAS and WSPG) for modeling hydraulic jump in an open channel is investigated. The numerical solutions are compared with a new experimental data set obtained for varying channel bottom slopes and flow rates. Both the models satisfactorily predict the flow depths and location of the jump. The end results indicate that the numerical models output is sensitive to the value of chosen roughness coefficient. For this application, WSPG model is easier to implement with few input variables.
C1 [Rao, Prasada] Calif State Univ Fullerton, Dept Civil & Environm Engn, Fullerton, CA 92831 USA.
[Hromadka, Theodore V., II] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA.
RP Rao, P (reprint author), Calif State Univ Fullerton, Dept Civil & Environm Engn, Fullerton, CA 92831 USA.
EM prasad@fullerton.edu
NR 13
TC 0
Z9 0
U1 2
U2 4
PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 2193-1801
J9 SPRINGERPLUS
JI SpringerPlus
PD MAY 20
PY 2016
VL 5
AR 662
DI 10.1186/s40064-016-2199-0
PG 7
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DO2JM
UT WOS:000377606000001
PM 27350903
ER
PT J
AU Clifford, R
Sparks, M
Hosford, E
Ong, A
Richesson, D
Fraser, S
Kwak, Y
Miller, S
Julius, M
McGann, P
Lesho, E
AF Clifford, Robert
Sparks, Michael
Hosford, Eve
Ong, Ana
Richesson, Douglas
Fraser, Susan
Kwak, Yoon
Miller, Sonia
Julius, Michael
McGann, Patrick
Lesho, Emil
TI Correlating Cleaning Thoroughness with Effectiveness and Briefly
Intervening to Affect Cleaning Outcomes: How Clean Is Cleaned?
SO PLOS ONE
LA English
DT Article
ID RESISTANT STAPHYLOCOCCUS-AUREUS; DISINFECTION TISSUE DISPENSERS;
COMPARING SURFACE DISINFECTION; CARE-ASSOCIATED INFECTIONS;
EVIDENCE-BASED DESIGN; HOSPITAL ROOM; CLINICAL-PRACTICE; OVERWEIGHT;
PARADIGM; PITFALLS
AB Objectives
The most efficient approach to monitoring and improving cleaning outcomes remains unresolved. We sought to extend the findings of a previous study by determining whether cleaning thoroughness (dye removal) correlates with cleaning efficacy (absence of molecular or cultivable biomaterial) and whether one brief educational intervention improves cleaning outcomes.
Design
Before-after trial.
Setting
Newly built community hospital.
Intervention
90 minute training refresher with surface-specific performance results.
Methods
Dye removal, measured by fluorescence, and biomaterial removal and acquisition, measured with culture and culture-independent PCR-based assays, were clandestinely assessed for eight consecutive months. At this midpoint, results were presented to the cleaning staff (intervention) and assessments continued for another eight consecutive months.
Results
1273 surfaces were sampled before and after terminal room cleaning. In the short-term, dye removal increased from 40.3% to 50.0% (not significant). For the entire study period, dye removal also improved but not significantly. After the intervention, the number of rooms testing positive for specific pathogenic species by culturing decreased from 55.6% to 36.6% (not significant), and those testing positive by PCR fell from 80.6% to 53.7%(P = 0.016). For nonspecific biomaterial on surfaces: a) removal of cultivable Gram-negatives (GN) trended toward improvement (P = 0.056); b) removal of any cultivable growth was unchanged but acquisition (detection of biomaterial on post-cleaned surfaces that were contaminant-free before cleaning) worsened (P = 0.017); c) removal of PCR-based detection of bacterial DNA improved (P = 0.046), but acquisition worsened (P = 0.003); d) cleaning thoroughness and efficacy were not correlated.
Conclusion
At this facility, a minor intervention or minimally more aggressive cleaning may reduce pathogen-specific contamination, but not without unintended consequences.
C1 [Clifford, Robert; Sparks, Michael; Hosford, Eve; Ong, Ana; Richesson, Douglas; Kwak, Yoon; Julius, Michael; McGann, Patrick; Lesho, Emil] Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD USA.
[Fraser, Susan; Miller, Sonia] Ft Belvoir Community Hosp, Dept Infect Dis & Infect Control, Ft Belvoir, VA USA.
RP Lesho, E (reprint author), Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD USA.
EM carolinelesho@yahoo.com
FU U.S. Army Medical Command; Department of Defense Global Emerging
Infection Surveillance and Response System
FX This work was funded by the U.S. Army Medical Command and the Department
of Defense Global Emerging Infection Surveillance and Response System.
The funders had no role in study design, data collection and analysis,
decision to publish, or preparation of the manuscript.
NR 27
TC 0
Z9 0
U1 2
U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 19
PY 2016
VL 11
IS 5
AR e0155779
DI 10.1371/journal.pone.0155779
PG 12
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DM4BR
UT WOS:000376291100100
PM 27196635
ER
PT J
AU Lesho, E
Clifford, R
Onmus-Leone, F
Appalla, L
Snesrud, E
Kwak, Y
Ong, A
Maybank, R
Waterman, P
Rohrbeck, P
Julius, M
Roth, A
Martinez, J
Nielsen, L
Steele, E
McGann, P
Hinkle, M
AF Lesho, Emil
Clifford, Robert
Onmus-Leone, Fatma
Appalla, Lakshmi
Snesrud, Erik
Kwak, Yoon
Ong, Ana
Maybank, Rosslyn
Waterman, Paige
Rohrbeck, Patricia
Julius, Michael
Roth, Amanda
Martinez, Joshua
Nielsen, Lindsey
Steele, Eric
McGann, Patrick
Hinkle, Mary
TI The Challenges of Implementing Next Generation Sequencing Across a Large
Healthcare System, and the Molecular Epidemiology and Antibiotic
Susceptibilities of Carbapenemase-Producing Bacteria in the Healthcare
System of the US Department of Defense
SO PLOS ONE
LA English
DT Article
ID ANTIMICROBIAL RESISTANCE; GENOME; QUALITY; PROGRAM; TIME
AB Methods
All phenotypically carbapenem resistant bacteria underwent CarbaNP (R) testing and PCR, followed by NGS. Commercial (Newbler and Geneious), on-line (ResFinder), and opensource software (Btrim, FLASh, Bowtie2, an Samtools) were used for assembly, SNP detection and clustering. Laboratory capacity, throughput, and response time were assessed.
Results
From 2009 through 2015, 27,000 multidrug-resistant Gram-negative isolates were submitted. 225 contained carbapenemase-encoding genes (most commonly bla(KPC), bla(NDM), and bla(OXA23)). These were found in 15 species from 146 inpatients in 19 facilities. Genetically related CPB were found in more than one hospital. Other clusters or outbreaks were not clonal and involved genetically related plasmids, while some involved several unrelated plasmids. Relatedness depended on the clustering algorithm used. Transmission patterns of plasmids and other mobile genetic elements could not be determined without ultra-long read, single-molecule real-time sequencing. 80% of carbapenem-resistant phenotypes retained susceptibility to aminoglycosides, and 70% retained susceptibility to fluoroquinolones. However, among the CPB-confirmed genotypes, fewer than 25% retained susceptibility to aminoglycosides or fluoroquinolones.
Conclusion
Although NGS is increasingly acclaimed to revolutionize clinical practice, resource-constrained environments, large or geographically dispersed healthcare networks, and military or government-funded public health laboratories are likely to encounter constraints and challenges as they implement NGS across their health systems. These include lack of standardized definitions and quality control metrics, limitations of short-read sequencing, insufficient bandwidth, and the current limited availability of very expensive and scarcely available sequencing platforms. Possible solutions and mitigations are also proposed.
C1 [Lesho, Emil; Clifford, Robert; Onmus-Leone, Fatma; Appalla, Lakshmi; Snesrud, Erik; Kwak, Yoon; Ong, Ana; Maybank, Rosslyn; Julius, Michael; Roth, Amanda; Martinez, Joshua; McGann, Patrick; Hinkle, Mary] Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Antimicrobial Resistance Monitoring & Res ARMoR P, Silver Spring, MD USA.
[Waterman, Paige] Armed Forces Hlth Surveillance Sect, Global Emerging Infect Dis Surveillance & Respons, Silver Spring, MD USA.
[Rohrbeck, Patricia] Armed Forces Hlth Surveillance Ctr, Epidemiol & Anal Sect, Silver Spring, MD USA.
[Nielsen, Lindsey; Steele, Eric] San Antonio Mil Med Ctr, Dept Lab Med, San Antonio, TX USA.
RP Lesho, E (reprint author), Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Antimicrobial Resistance Monitoring & Res ARMoR P, Silver Spring, MD USA.
EM carolinelesho@yahoo.com
FU Global Emerging Infection Surveillance System, Armed Forces Health
Surveillance Center; U.S. Army Medical Command
FX This work was supported by the Global Emerging Infection Surveillance
System, Armed Forces Health Surveillance Center and the U.S. Army
Medical Command. The funders had no role in study design, data
collection and analysis, decision to publish, or preparation of the
manuscript.
NR 21
TC 0
Z9 0
U1 3
U2 6
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 19
PY 2016
VL 11
IS 5
AR e0155770
DI 10.1371/journal.pone.0155770
PG 12
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DM4BR
UT WOS:000376291100098
PM 27196272
ER
PT J
AU Joachim, A
Bauer, A
Joseph, S
Geldmacher, C
Munseri, PJ
Aboud, S
Missanga, M
Mann, P
Wahren, B
Ferrari, G
Polonis, VR
Robb, ML
Weber, J
Tatoud, R
Maboko, L
Hoelscher, M
Lyamuya, EF
Biberfeld, G
Sandstrom, E
Kroidl, A
Bakari, M
Nilsson, C
McCormack, S
AF Joachim, Agricola
Bauer, Asli
Joseph, Sarah
Geldmacher, Christof
Munseri, Patricia J.
Aboud, Said
Missanga, Marco
Mann, Philipp
Wahren, Britta
Ferrari, Guido
Polonis, Victoria R.
Robb, Merlin L.
Weber, Jonathan
Tatoud, Roger
Maboko, Leonard
Hoelscher, Michael
Lyamuya, Eligius F.
Biberfeld, Gunnel
Sandstrom, Eric
Kroidl, Arne
Bakari, Muhammad
Nilsson, Charlotta
McCormack, Sheena
TI Boosting with Subtype C CN54rgp140 Protein Adjuvanted with
Glucopyranosyl Lipid Adjuvant after Priming with HIV-DNA and HIV-MVA Is
Safe and Enhances Immune Responses: A Phase I Trial
SO PLOS ONE
LA English
DT Article
ID VACCINIA VIRUS ANKARA; EFFICACY TRIAL; DOUBLE-BLIND; HEALTHY-ADULTS;
VACCINATION; BROAD; IMMUNOGENICITY; INFECTION; TANZANIA; THAILAND
AB Background
A vaccine against HIV is widely considered the most effective and sustainable way of reducing new infections. We evaluated the safety and impact of boosting with subtype C CN54rgp140 envelope protein adjuvanted in glucopyranosyl lipid adjuvant (GLA-AF) in Tanzanian volunteers previously given three immunizations with HIV-DNA followed by two immunizations with recombinant modified vaccinia virus Ankara (HIV-MVA).
Methods
Forty volunteers (35 vaccinees and five placebo recipients) were given two CN54rgp140/GLA-AF immunizations 30-71 weeks after the last HIV-MVA vaccination. These immunizations were delivered intramuscularly four weeks apart.
Results
The vaccine was safe and well tolerated except for one episode of asymptomatic hypoglycaemia that was classified as severe adverse event. Two weeks after the second HIV-MVA vaccination 34 (97%) of the 35 previously vaccinated developed Env-specific binding antibodies, and 79% and 84% displayed IFN-gamma ELISpot responses to Gag and Env, respectively. Binding antibodies to subtype C Env (included in HIV-DNA and protein boost), subtype B Env (included only in HIV-DNA) and CRF01_AE Env (included only in HIV-MVA) were significantly boosted by the CN54rgp140/GLA-AF immunizations. Functional antibodies detected using an infectious molecular clone virus/peripheral blood mononuclear cell neutralization assay, a pseudovirus/TZM-bl neutralization assay or by assays for antibody-dependent cellular cytotoxicity (ADCC) were not significantly boosted. In contrast, T-cell proliferative responses to subtype B MN antigen and IFN-gamma ELISpot responses to Env peptides were significantly enhanced. Four volunteers not primed with HIV-DNA and HIV-MVA before the CN54rgp140/ GLA-AF immunizations mounted an antibody response, while cell-mediated responses were rare. After the two Env subtype C protein immunizations, a trend towards higher median subtype C Env binding antibody titers was found in vaccinees who had received HIV-DNA and HIV-MVA prior to the two Env protein immunizations as compared to unprimed vaccinees (p = 0.07).
Conclusion
We report excellent tolerability, enhanced binding antibody responses and Env-specific cell-mediated immune responses but no ADCC antibody increase after two immunizations with a subtype C rgp140 protein adjuvanted in GLA-AF in healthy volunteers previously immunized with HIV-DNA and HIV-MVA.
C1 [Joachim, Agricola; Aboud, Said; Lyamuya, Eligius F.] Muhimbili Univ Hlth & Allied Sci, Dept Microbiol & Immunol, Dar Es Salaam, Tanzania.
[Joachim, Agricola; Wahren, Britta; Biberfeld, Gunnel; Nilsson, Charlotta] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden.
[Bauer, Asli; Missanga, Marco; Mann, Philipp; Maboko, Leonard; Hoelscher, Michael; Kroidl, Arne] Natl Inst Med Res Mbeya, Med Res Ctr, Mbeya, Tanzania.
[Bauer, Asli; Geldmacher, Christof; Hoelscher, Michael; Kroidl, Arne] Univ Munich LMU, Med Ctr, Dept Infect Dis & Trop Med, Munich, Germany.
[Joseph, Sarah; McCormack, Sheena] UCL, MRC, Clin Trials Unit, London, England.
[Geldmacher, Christof; Hoelscher, Michael; Kroidl, Arne] German Ctr Infect Res DZIF, Partner Site Munich, Munich, Germany.
[Munseri, Patricia J.; Bakari, Muhammad] Muhimbili Univ Hlth & Allied Sci, Dept Internal Med, Dar Es Salaam, Tanzania.
[Ferrari, Guido] Duke Univ, Med Ctr, Dept Surg & Mol Genet & Microbiol, Durham, NC USA.
[Polonis, Victoria R.; Robb, Merlin L.] Walter Reed Army Inst Res, Mil HIV Res Program, Silver Spring, MD USA.
[Robb, Merlin L.] Henry M Jackson Fdn Adv Mil Med, Mil HIV Res Program, Bethesda, MD USA.
[Weber, Jonathan; Tatoud, Roger] Univ London Imperial Coll Sci Technol & Med, London, England.
[Sandstrom, Eric] Soder Sjukhuset, Karolinska Insitutet, Venhalsan, S-10064 Stockholm, Sweden.
[Nilsson, Charlotta] Publ Hlth Agcy Sweden, Solna, Sweden.
[Nilsson, Charlotta] Karolinska Inst Huddinge, Dept Lab Med, Stockholm, Sweden.
[Mann, Philipp] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, 1124 Columbia St, Seattle, WA 98104 USA.
[Tatoud, Roger] Chelsea & Westminster NHS Fdn Trust, St Stephens Ctr, Int AIDS Vaccine Initiat IAVI, London, England.
RP Joachim, A (reprint author), Muhimbili Univ Hlth & Allied Sci, Dept Microbiol & Immunol, Dar Es Salaam, Tanzania.; Joachim, A (reprint author), Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden.
EM agricola.joachim@ki.se
RI Hoelscher, Michael/D-3436-2012
FU European and Developing Countries Clinical Trials Partnership (EDCTP)
[CT.2006.33111.007, CT.2006.33111.001]; German Ministry of Education and
Research (BMBF) [01KA0802]; Swedish International Development
Cooperation Agency (Sida); Swedish Embassy in Tanzania; CAVD [1032144];
Duke University Center for AIDS Research (CFAR) Grant [P30 AI64518]; US
Military HIV Research program, Walter Reed Army Institute of Research
(WRAIR); UKHVC - Wellcome Trust [083844/Z/07/Z]; Public Health Agency of
Sweden; MUHAS; Regional HIV/AIDS Team for Africa at the Embassy of
Sweden in Lusaka - Sweden [2150012801]; Regional HIV/AIDS Team for
Africa at the Embassy of Sweden in Lusaka - Norway [2150012801]
FX The Swedish Institute for Communicable Disease Control (currently the
Public Health Agency of Sweden) and MUHAS sponsored the trial. Financial
support for the trial was received from the European and Developing
Countries Clinical Trials Partnership (EDCTP) for two grants (Grant ID
CT.2006.33111.007 and CT.2006.33111.001), the German Ministry of
Education and Research (BMBF, Grant ID: 01KA0802), the Swedish
International Development Cooperation Agency (Sida), the Swedish Embassy
in Tanzania and the Regional HIV/AIDS Team for Africa at the Embassy of
Sweden in Lusaka jointly funded by Sweden and Norway (Sida contribution
no. 2150012801). This study was partially supported by a technology
transfer through the CAVD (Grant ID: 1032144) and Duke University Center
for AIDS Research (CFAR) Grant (P30 AI64518), the US Military HIV
Research program, Walter Reed Army Institute of Research (WRAIR) and
through the UKHVC funded by the Wellcome Trust (Grant award no.
083844/Z/07/Z). The funders had no role in study design, data collection
and analysis, decision to publish, or preparation of the manuscript.
NR 30
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PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 18
PY 2016
VL 11
IS 5
AR e0155702
DI 10.1371/journal.pone.0155702
PG 18
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DM3ZU
UT WOS:000376286100083
PM 27192151
ER
PT J
AU Graves, SF
Kouriba, B
Diarra, I
Daou, M
Niangaly, A
Coulibaly, D
Keita, Y
Laurens, MB
Berry, AA
Vekemans, J
Ballou, WR
Lanar, DE
Dutta, S
Heppner, DG
Soisson, L
Diggs, CL
Thera, MA
Doumbo, OK
Plowe, CV
Sztein, MB
Lyke, KE
AF Graves, Shawna F.
Kouriba, Bourema
Diarra, Issa
Daou, Modibo
Niangaly, Amadou
Coulibaly, Drissa
Keita, Yamoussa
Laurens, Matthew B.
Berry, Andrea A.
Vekemans, Johan
Ballou, W. Ripley
Lanar, David E.
Dutta, Sheetij
Heppner, D. Gray
Soisson, Lorraine
Diggs, Carter L.
Thera, Mahamadou A.
Doumbo, Ogobara K.
Plowe, Christopher V.
Sztein, Marcelo B.
Lyke, Kirsten E.
TI Strain-specific Plasmodium falciparum multifunctional CD4(+) T cell
cytokine expression in Malian children immunized with the FMP2.1/AS02(A)
vaccine candidate
SO VACCINE
LA English
DT Article
DE Malaria; Pediatric; T cell; Multifunctional; AMA1; FMP2.1/AS02(A)
ID APICAL MEMBRANE ANTIGEN-1; BLOOD-STAGE MALARIA; MEDIATED-IMMUNITY;
PROTECTIVE IMMUNITY; GENETIC DIVERSITY; SURFACE-ANTIGEN; INFECTION;
ADULTS; IMMUNOGENICITY; EFFICACY
AB Based on Plasmodium falciparum (Pf) apical membrane antigen 1 (AMA1) from strain 3D7, the malaria vaccine candidate FMP2.1/AS02(A) showed strain-specific efficacy in a Phase 2 clinical trial in 400 Malian children randomized to 3 doses of the AMA1 vaccine candidate or control rabies vaccine on days 0, 30 and 60. A subset of 10 Pf(-) (i.e., no clinical malaria episodes) AMA1 recipients, 11 Pf(+) (clinical malaria episodes with parasites with 3D7 or Fab9-type AMA1 cluster 1 loop [c1L]) AMA1 recipients, and 10 controls were randomly chosen for analysis. Peripheral blood mononuclear cells (PBMCs) isolated on days 0, 90 and 150 were stimulated with full-length 3D7 AMA1 and c1L from strains 3D7 (c3D7) and Fab9 (cFab9). Production of IFN-gamma, TNF-alpha, IL-2, and/or IL-17A was analyzed by flow cytometry. Among AMA1 recipients, 18/21 evaluable samples stimulated with AMA1 demonstrated increased IFN-gamma, TNF-alpha, and IL-2 derived from CD4(+) T cells by day 150 compared to 0/10 in the control group (p < 0.0001). Among AMA1 vaccines, CD4(+) cells expressing both TNF-alpha and IL-2 were increased in Pf(-) children compared to Pf(+) children. When PBMCs were stimulated with c3D7 and cFab9 separately, 4/18 AMA1 recipients with an AMA1-specific CD4(+) response had a significant response to one or both c1L. This suggests that recognition of the AMA1 antigen is not dependent upon c1L alone. In summary, AMA1-specific T cell responses were notably increased in children immunized with an AMA1-based vaccine candidate. The role of CD4(+)TNF-alpha IL-2(+)-expressing T cells in vaccine-induced strain-specific protection against clinical malaria requires further exploration. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Graves, Shawna F.; Laurens, Matthew B.; Berry, Andrea A.; Plowe, Christopher V.; Sztein, Marcelo B.; Lyke, Kirsten E.] Univ Maryland, Sch Med, Ctr Vaccine Dev, 685 W Baltimore St,HSF 1 Room 480, Baltimore, MD 21201 USA.
[Kouriba, Bourema; Diarra, Issa; Daou, Modibo; Niangaly, Amadou; Coulibaly, Drissa; Keita, Yamoussa; Thera, Mahamadou A.; Doumbo, Ogobara K.] Univ Sci Techn & Technol, Malaria Res & Training Ctr, Bamako, Mali.
[Laurens, Matthew B.; Berry, Andrea A.; Plowe, Christopher V.] Univ Maryland, Howard Hughes Med Inst, Baltimore, MD 21201 USA.
[Vekemans, Johan; Ballou, W. Ripley] GlaxoSmithKline Vaccines, Rixensart, Belgium.
[Lanar, David E.; Dutta, Sheetij; Heppner, D. Gray] Walter Reed Army Inst Res, Mil Malaria Res Program, Silver Spring, MD USA.
[Soisson, Lorraine; Diggs, Carter L.] US Agcy Int Dev, Malaria Vaccine Dev Program, Washington, DC 20523 USA.
RP Lyke, KE (reprint author), Univ Maryland, Sch Med, Ctr Vaccine Dev, 685 W Baltimore St,HSF 1 Room 480, Baltimore, MD 21201 USA.
EM klyke@medicine.umaryland.edu
RI Laurens, Matthew/E-7293-2013
OI Laurens, Matthew/0000-0003-3874-581X
FU National Institute of Allergy and Infectious Diseases [N01AI85346,
U19AI065683]; Fogarty International Center, National Institutes of
Health [D43TW001589]; United States Department of Defense
[W81XWH-06-1-0427]; United States Agency for International Development;
United States Agency for International Development, Washington, D.C.;
Military Infectious Diseases Research Program, Fort Detrick, MD;
International Collaboration on Infectious Diseases Research
[U01AI065683-06]; Howard Hughes Medical Institute
FX We would like to thank the people of Bandiagara, Mali for their
participation and support of this vaccine study. The Walter Reed Army
Institute of Research (WRAIR) kindly provided the purified recombinant
AMA1-derived protein FMP2.1 used for cellular stimulation and formed the
basis of the FMP2.1/AS02A vaccine candidate for this study.
Additionally, we would like to thank GlaxoSmithKline Vaccines for
providing the AS02A adjuvant. The conduct of the trial was
supported by a contract N01AI85346 and a cooperative agreement
U19AI065683 from the National Institute of Allergy and Infectious
Diseases, grant D43TW001589 from the Fogarty International Center,
National Institutes of Health and contract W81XWH-06-1-0427 from the
United States Department of Defense and the United States Agency for
International Development. Vaccine production was supported by the
United States Agency for International Development, Washington, D.C. and
by the Military Infectious Diseases Research Program, Fort Detrick, MD.
The immunologic assays and SG were funded by contract U01AI065683-06
from the International Collaboration on Infectious Diseases Research.
CVP and MBL are supported by the Howard Hughes Medical Institute. This
abstract was presented in part to the American Society of Tropical
Medicine and Hygiene, Washington, D.C., November 2013, abstract #1443.
NR 42
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PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
EI 1873-2518
J9 VACCINE
JI Vaccine
PD MAY 17
PY 2016
VL 34
IS 23
BP 2546
EP 2555
DI 10.1016/j.vaccine.2016.04.019
PG 10
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA DM9SC
UT WOS:000376705000004
PM 27087149
ER
PT J
AU Howell, KA
Qiu, XG
Brannan, JM
Bryan, C
Davidson, E
Holtsberg, FW
Wec, AZ
Shulenin, S
Biggins, JE
Douglas, R
Enterlein, SG
Turner, HL
Pallesen, J
Murin, CD
He, SH
Kroeker, A
Vu, H
Herbert, AS
Fusco, ML
Nyakatura, EK
Lai, JR
Keck, ZY
Foung, SKH
Saphire, EO
Zeitlin, L
Ward, AB
Chandran, K
Doranz, BJ
Kobinger, GP
Dye, JM
Aman, MJ
AF Howell, Katie A.
Qiu, Xiangguo
Brannan, Jennifer M.
Bryan, Christopher
Davidson, Edgar
Holtsberg, Frederick W.
Wec, Anna Z.
Shulenin, Sergey
Biggins, Julia E.
Douglas, Robin
Enterlein, Sven G.
Turner, Hannah L.
Pallesen, Jesper
Murin, Charles D.
He, Shihua
Kroeker, Andrea
Vu, Hong
Herbert, Andrew S.
Fusco, Marnie L.
Nyakatura, Elisabeth K.
Lai, Jonathan R.
Keck, Zhen-Yong
Foung, Steven K. H.
Saphire, Erica Ollmann
Zeitlin, Larry
Ward, Andrew B.
Chandran, Kartik
Doranz, Benjamin J.
Kobinger, Gary P.
Dye, John M.
Aman, M. Javad
TI Antibody Treatment of Ebola and Sudan Virus Infection via a Uniquely
Exposed Epitope within the Glycoprotein Receptor-Binding Site
SO CELL REPORTS
LA English
DT Article
ID NIEMANN-PICK C1; MONOCLONAL-ANTIBODIES; NONHUMAN-PRIMATES; MOLECULAR
CHARACTERIZATION; NEUTRALIZING ANTIBODY; FILOVIRUS ENTRY; MARBURG VIRUS;
GUINEA-PIG; DISEASE; PROPHYLAXIS
AB Previous efforts to identify cross-neutralizing antibodies to the receptor-binding site (RBS) of ebolavirus glycoproteins have been unsuccessful, largely because the RBS is occluded on the viral surface. We report a monoclonal antibody (FVM04) that targets a uniquely exposed epitope within the RBS; cross-neutralizes Ebola (EBOV), Sudan (SUDV), and, to a lesser extent, Bundibugyo viruses; and shows protection against EBOV and SUDV in mice and guinea pigs. The antibody cocktail ZMapp (TM) is remarkably effective against EBOV (Zaire) but does not cross-neutralize other ebolaviruses. By replacing one of the ZMapp (TM) components with FVM04, we retained the anti-EBOV efficacy while extending the breadth of protection to SUDV, thereby generating a cross-protective antibody cocktail. In addition, we report several mutations at the base of the ebolavirus glycoprotein that enhance the binding of FVM04 and other cross-reactive antibodies. These findings have important implications for pan-ebolavirus vaccine development and defining broadly protective antibody cocktails.
C1 [Howell, Katie A.; Holtsberg, Frederick W.; Shulenin, Sergey; Biggins, Julia E.; Douglas, Robin; Enterlein, Sven G.; Vu, Hong; Aman, M. Javad] Integrated BioTherapeut Inc, Gaithersburg, MD 20878 USA.
[Qiu, Xiangguo; He, Shihua; Kroeker, Andrea; Kobinger, Gary P.] Publ Hlth Agcy Canada, Natl Microbiol Lab, Special Pathogens Program, Winnipeg, MB R3E 3R2, Canada.
[Qiu, Xiangguo; He, Shihua; Kroeker, Andrea; Kobinger, Gary P.] Univ Manitoba, Dept Med Microbiol, Winnipeg, MB R3E 0J9, Canada.
[Qiu, Xiangguo; He, Shihua; Kroeker, Andrea; Kobinger, Gary P.] Univ Manitoba, Dept Immunol, Winnipeg, MB R3E 0J9, Canada.
[Brannan, Jennifer M.; Herbert, Andrew S.; Dye, John M.] US Army Med Res Inst Infect Dis, Frederick, MD 21702 USA.
[Bryan, Christopher; Davidson, Edgar; Doranz, Benjamin J.] Integral Mol, Philadelphia, PA 19104 USA.
[Turner, Hannah L.; Pallesen, Jesper; Murin, Charles D.; Ward, Andrew B.] Scripps Res Inst, Dept Integrat Struct & Computat Biol, La Jolla, CA 92037 USA.
[Murin, Charles D.; Fusco, Marnie L.; Saphire, Erica Ollmann] Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA.
[Saphire, Erica Ollmann] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA.
[Wec, Anna Z.; Chandran, Kartik] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA.
[Nyakatura, Elisabeth K.; Lai, Jonathan R.] Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA.
[Keck, Zhen-Yong; Foung, Steven K. H.] Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA.
[Zeitlin, Larry] Mapp Biopharmaceut, San Diego, CA 92121 USA.
RP Aman, MJ (reprint author), Integrated BioTherapeut Inc, Gaithersburg, MD 20878 USA.
EM javad@integratedbiotherapeutics.com
RI Ward, Andrew/F-9203-2014
OI Ward, Andrew/0000-0001-7153-3769
FU U.S. Defense Threat Reduction Agency (DTRA) [HDTRA1-13-C-0015]; NIH [U19
AI109762, HHSN272201400058C, U19AI109762]; Public Health Agency of
Canada (PHAC); National Science Foundation; DAAD (Deutscher Akademischer
Austauschdienst [German Academic Exchange Service]) fellowship
FX This work was supported by a contract (HDTRA1-13-C-0015) from the U.S.
Defense Threat Reduction Agency (DTRA) to M.J.A., grant U19 AI109762
from the NIH to E.O.S., and NIH contract HHSN272201400058C to B.J.D.
J.R.L. acknowledges funding from the NIH (U19AI109762). This work was
also partially supported by the Public Health Agency of Canada (PHAC).
We thank Andrew McNeal and Rachel Fong for valuable technical
assistance. C.D.M. is supported by a pre-doctoral fellowship from the
National Science Foundation. E.K.N. was supported by a DAAD (Deutscher
Akademischer Austauschdienst [German Academic Exchange Service])
fellowship. Opinions, interpretations, conclusions, and recommendations
are those of the authors and are not necessarily endorsed by the U.S.
Army. M.J.A. is a shareholder of Integrated Biotherapeutics. S.G.E.,
F.W.H., H.V., R.D., and S.S. own stock options in Integrated
Biotherapeutics.
NR 52
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U2 19
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 2211-1247
J9 CELL REP
JI Cell Reports
PD MAY 17
PY 2016
VL 15
IS 7
BP 1514
EP 1526
DI 10.1016/j.celrep.2016.04.026
PG 13
WC Cell Biology
SC Cell Biology
GA DM2GO
UT WOS:000376165300015
PM 27160900
ER
PT J
AU Jin, XN
Potter, B
Luong, TL
Nelson, J
Vuong, C
Potter, C
Xie, LS
Zhang, J
Zhang, P
Sousa, J
Li, QG
Pybus, BS
Kreishman-Deitrick, M
Hickman, M
Smith, PL
Paris, R
Reichard, G
Marcsisin, SR
AF Jin, Xiannu
Potter, Brittney
Luong, Thu-lan
Nelson, Jennifer
Chau Vuong
Potter, Corttney
Xie, Lisa
Zhang, Jing
Zhang, Ping
Sousa, Jason
Li, Qigui
Pybus, Brandon S.
Kreishman-Deitrick, Mara
Hickman, Mark
Smith, Philip L.
Paris, Robert
Reichard, Gregory
Marcsisin, Sean R.
TI Pre-clinical evaluation of CYP 2D6 dependent drug-drug interactions
between primaquine and SSRI/SNRI antidepressants
SO MALARIA JOURNAL
LA English
DT Article
DE Primaquine; Antimalarial; Drug metabolism; Pharmacokinetics; CYP 2D6;
Relapsing malaria; Drug-drug interactions
ID SEROTONIN REUPTAKE INHIBITORS; ADULT THAI SUBJECTS; VIVAX MALARIA;
PLASMA-CONCENTRATIONS; IN-VITRO; METABOLISM; PHARMACOKINETICS;
VENLAFAXINE; FLUOXETINE; RESISTANCE
AB Background: The liver-stage anti-malarial activity of primaquine and other 8-aminoquinoline molecules has been linked to bio-activation through CYP 2D6 metabolism. Factors such as CYP 2D6 poor metabolizer status and/or co-administration of drugs that inhibit/interact with CYP 2D6 could alter the pharmacological properties of primaquine.
Methods: In the present study, the inhibitory potential of the selective serotonin reuptake inhibitor (SSRI) and serotonin norepinephrine reuptake inhibitor (SNRI) classes of antidepressants for CYP 2D6-mediated primaquine metabolism was assessed using in vitro drug metabolism and in vivo pharmacological assays.
Results: The SSRI/SNRI classes of drug displayed a range of inhibitory activities on CYP 2D6-mediated metabolism of primaquine in vitro (IC50 1-94 mu M). Fluoxetine and paroxetine were the most potent inhibitors (IC50 similar to 1 mu M) of CYP 2D6-mediated primaquine metabolism, while desvenlafaxine was the least potent (IC50 similar to 94 mu M). The most potent CYP 2D6 inhibitor, fluoxetine, was chosen to investigate the potential pharmacological consequences of co-administration with primaquine in vivo. The pharmacokinetics of a CYP 2D6-dependent primaquine metabolite were altered upon co-administration with fluoxetine. Additionally, in a mouse malaria model, co-administration of fluoxetine with primaquine reduced primaquine anti-malarial efficacy.
Conclusions: These results are the first from controlled pre-clinical experiments that indicate that primaquine pharmacological properties can be modulated upon co-incubation/administration with drugs that are known to interact with CYP 2D6. These results highlight the potential for CYP 2D6-mediated drug-drug interactions with primaquine and indicate that the SSRI/SNRI antidepressants could be used as probe molecules to address the primaquine-CYP 2D6 DDI link in clinical studies. Additionally, CYP 2D6-mediated drug-drug interactions can be considered when examining the possible causes of human primaquine therapy failures.
C1 [Jin, Xiannu; Potter, Brittney; Luong, Thu-lan; Nelson, Jennifer; Chau Vuong; Potter, Corttney; Xie, Lisa; Zhang, Jing; Zhang, Ping; Sousa, Jason; Li, Qigui; Pybus, Brandon S.; Kreishman-Deitrick, Mara; Hickman, Mark; Smith, Philip L.; Paris, Robert; Reichard, Gregory; Marcsisin, Sean R.] Walter Reed Army Inst Res, Mil Malaria Res Program, Expt Therapeut Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
RP Marcsisin, SR (reprint author), Walter Reed Army Inst Res, Mil Malaria Res Program, Expt Therapeut Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM sean.r.marcsisin.mil@mail.mil
FU Military Infectious Diseases Research Program (MIDRP) project
[Q0302_12_WR_CS]
FX This work was supported by the Military Infectious Diseases Research
Program (MIDRP) project # Q0302_12_WR_CS. We would like to thank Dr.
Larry Walker, Dr. Babu Tekwani, Dr. Jim McChesney, and Dr. David Jollow
for their scientific guidance and suggestions. This material has been
NR 36
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U1 2
U2 2
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2875
J9 MALARIA J
JI Malar. J.
PD MAY 17
PY 2016
VL 15
AR 280
DI 10.1186/s12936-016-1329-z
PG 10
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA DM0XC
UT WOS:000376068200002
PM 27188854
ER
PT J
AU Anquillare, EL
Miller, OD
Hsu, CW
DeLacy, BG
Joannopoulos, JD
Johnson, SG
Soljacic, M
AF Anquillare, E. L.
Miller, O. D.
Hsu, C. W.
DeLacy, B. G.
Joannopoulos, J. D.
Johnson, S. G.
Soljacic, M.
TI Efficient, designable, and broad-bandwidth optical extinction via
aspect-ratio-tailored silver nanodisks
SO OPTICS EXPRESS
LA English
DT Article
ID GOLD NANOPARTICLES; PLASMON RESPONSE; LIGHT-ABSORPTION; SOLAR-CELLS;
SHAPE; NANOSTRUCTURES; OPTIMIZATION; RULES
AB Subwavelength resonators, ranging from single atoms to metallic nanoparticles, typically exhibit a narrow-bandwidth response to optical excitations. We computationally design and experimentally synthesize tailored distributions of silver nanodisks to extinguish light over broad and varied frequency windows. We show that metallic nanodisks are 2-10x more efficient in absorbing and scattering light than common structures, and can approach fundamental limits to broadband scattering for subwavelength particles. We measure broadband extinction per volume that closely approaches theoretical predictions over three representative visible-range wavelength windows, confirming the high efficiency of nanodisks and demonstrating the collective power of computational design and experimental precision for developing new photonics technologies. (C) 2016 Optical Society of America
C1 [Anquillare, E. L.; Hsu, C. W.; Joannopoulos, J. D.; Soljacic, M.] MIT, Dept Phys, Cambridge, MA 02139 USA.
[Miller, O. D.; Johnson, S. G.] MIT, Dept Math, Cambridge, MA 02139 USA.
[Hsu, C. W.] Yale Univ, Dept Appl Phys, New Haven, CT 06520 USA.
[DeLacy, B. G.] US Army, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA.
RP Anquillare, EL (reprint author), MIT, Dept Phys, Cambridge, MA 02139 USA.
EM eanquill@mit.edu
RI Hsu, Chia Wei/G-5486-2011
OI Hsu, Chia Wei/0000-0002-9609-7155
FU U. S. Army Research Laboratory; U. S. Army Research Office through the
Institute for Soldier Nanotechnologies [W911NF-13-D-0001]; MRSEC Program
National Science Foundation (NSF) [DMR-1419807]; MIT Deshpande Center
for Technological Innovation
FX We thank Yong Zhang & Tim McClure for instrumentation assistance. This
work was supported by the U. S. Army Research Laboratory and the U. S.
Army Research Office through the Institute for Soldier Nanotechnologies
under contract number W911NF-13-D-0001). It was also supported in part
by MRSEC Program of the National Science Foundation (NSF) under contract
DMR-1419807 and the MIT Deshpande Center for Technological Innovation.
NR 51
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U1 1
U2 1
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 1094-4087
J9 OPT EXPRESS
JI Opt. Express
PD MAY 16
PY 2016
VL 24
IS 10
AR 261563
DI 10.1364/OE.24.010806
PG 11
WC Optics
SC Optics
GA DM5IE
UT WOS:000376380700082
PM 27409901
ER
PT J
AU Goupil, BA
McNulty, MA
Martin, MJ
McCracken, MK
Christofferson, RC
Mores, CN
AF Goupil, Brad A.
McNulty, Margaret A.
Martin, Matthew J.
McCracken, Michael K.
Christofferson, Rebecca C.
Mores, Christopher N.
TI Novel Lesions of Bones and Joints Associated with Chikungunya Virus
Infection in Two Mouse Models of Disease: New Insights into Disease
Pathogenesis
SO PLOS ONE
LA English
DT Article
ID RHEUMATOID-ARTHRITIS; INBRED STRAINS; INFLAMMATORY DISEASE; CARTILAGE
REPAIR; MARROW NECROSIS; REUNION ISLAND; MICE; ARTHRALGIA;
MICROSTRUCTURE; MANIFESTATIONS
AB Chikungunya virus is an arbovirus spread predominantly by Aedes aegypti and Ae. albopictus mosquitoes, and causes debilitating arthralgia and arthritis. While these are common manifestations during acute infection and it has been suggested they can recur in patients chronically, gaps in knowledge regarding the pathogenesis still exist. Two established mouse models were utilized (adult IRF 3/7(-/-) (-/-) and wild-type C57BL/6J mice) to evaluate disease manifestations in bones and joints at various timepoints. Novel lesions in C57BL/6J mice consisted of periostitis (91%) and foci of cartilage of necrosis (50% of mice at 21 DPI). Additionally, at 21 DPI, 50% and 75% of mice exhibited periosteal bone proliferation affecting the metatarsal bones, apparent via histology and mu CT, respectively. mu CT analysis did not reveal any alterations in trabecular bone volume measurements in C57BL/6J mice. Novel lesions demonstrated in IRF 3/7(-/-) (-/-) mice at 5 DPI included focal regions of cartilage necrosis (20%), periosteal necrosis (66%), and multifocal ischemic bone marrow necrosis (100%). Contralateral feet in 100% of mice of both strains had similar, though milder lesions. Additionally, comparison of control IRF 3/7(-/-) (-/-) and wild-type C57BL/6J mice demonstrated differences in cortical bone. These experiments demonstrate novel manifestations of disease similar to those occurring in humans, adding insight into disease pathogenesis, and representing new potential targets for therapeutic interventions. Additionally, results demonstrate the utility of mu CT in studies of bone and joint pathology and illustrate differences in bone dynamics between mouse strains.
C1 [Goupil, Brad A.; McCracken, Michael K.; Christofferson, Rebecca C.; Mores, Christopher N.] Louisiana State Univ, Sch Vet Med, Dept Pathobiol Sci, Skip Bertman Dr, Baton Rouge, LA 70803 USA.
[McNulty, Margaret A.; Martin, Matthew J.] Louisiana State Univ, Sch Vet Med, Dept Comparat Biomed Sci, Skip Bertman Dr, Baton Rouge, LA 70803 USA.
[McCracken, Michael K.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD USA.
RP Goupil, BA (reprint author), Louisiana State Univ, Sch Vet Med, Dept Pathobiol Sci, Skip Bertman Dr, Baton Rouge, LA 70803 USA.
EM bgoupi1@lsu.edu
FU National Institutes of Health Centers of Biomedical Research Excellence
(COBRE) Phase III Award [1P30GM110760-01]; T32 training grant
[5T32OD011124-09]; Louisiana Board of Regents Traditional Enhancement
Grant LEQSF [(2013-14)-ENH-TR-06]
FX This work is supported by the National Institutes of Health Centers of
Biomedical Research Excellence (COBRE) Phase III Award 1P30GM110760-01
to CNM and T32 training grant 5T32OD011124-09 to BAG, and a Louisiana
Board of Regents Traditional Enhancement Grant LEQSF (2013-14)-ENH-TR-06
to MAM. The funders had no role in study design, data collection and
analysis, decision to publish, or preparation of the manuscript.
NR 62
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U1 1
U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 16
PY 2016
VL 11
IS 5
AR e0155243
DI 10.1371/journal.pone.0155243
PG 21
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DM3XH
UT WOS:000376279500030
PM 27182740
ER
PT J
AU Matters, DA
Lerch, AG
Hurst, AM
Szentmiklosi, L
Carroll, JJ
Detwiler, B
Revay, Z
McClory, JW
McHale, SR
Firestone, RB
Sleaford, BW
Krticka, M
Belgya, T
AF Matters, D. A.
Lerch, A. G.
Hurst, A. M.
Szentmiklosi, L.
Carroll, J. J.
Detwiler, B.
Revay, Zs.
McClory, J. W.
McHale, S. R.
Firestone, R. B.
Sleaford, B. W.
Krticka, M.
Belgya, T.
TI Investigation of Re-186 via radiative thermal-neutron capture on Re-185
SO PHYSICAL REVIEW C
LA English
DT Article
ID GAMMA ACTIVATION-ANALYSIS; BUDAPEST RESEARCH REACTOR; CROSS-SECTIONS;
NUCLEAR-DATA; RESONANCES; STRENGTH; STANDARDIZATION; WIDTHS; PGAA
AB Partial gamma-ray production cross sections and the total radiative thermal-neutron capture cross section for the Re-185(n,gamma) Re-186 reaction were measured using the Prompt Gamma Activation Analysis facility at the Budapest Research Reactor with an enriched Re-185 target. The Re-186 cross sections were standardized using well-known Cl-35(n,gamma) Cl-36 cross sections from irradiation of a stoichiometric (ReCl3)-Re-nat target. The resulting cross sections for transitions feeding the Re-186 ground state from low-lying levels below a cutoff energy of E-c = 746 keV were combined with a modeled probability of ground-state feeding from levels above E-c to arrive at a total cross section of sigma(0) = 111(6) b for radiative thermal-neutron capture on Re-185. A comparison of modeled discrete-level populations with measured transition intensities led to proposed revisions for seven tentative spin-parity assignments in the adopted level scheme for Re-186. Additionally, 102 primary gamma rays were measured, including 50 previously unknown. A neutron-separation energy of S-n = 6179.59(5) keV was determined from a global least-squares fit of the measured gamma-ray energies to the known Re-186 decay scheme. The total capture cross section and separation energy results are comparable to earlier measurements of these values.
C1 [Matters, D. A.; McClory, J. W.] US Air Force, Inst Technol, Wright Patterson AFB, OH 45433 USA.
[Lerch, A. G.; McHale, S. R.] Def Threat Reduct Agcy, Ft Belvoir, VA 22060 USA.
[Hurst, A. M.; Firestone, R. B.] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA.
[Hurst, A. M.] Univ Calif Berkeley, Dept Nucl Engn, Berkeley, CA 94720 USA.
[Szentmiklosi, L.; Belgya, T.] Hungarian Acad Sci, Ctr Energy Res, H-1525 Budapest, Hungary.
[Carroll, J. J.] US Army Res Lab, Adelphi, MD 20783 USA.
[Detwiler, B.] Youngstown State Univ, Youngstown, OH 44555 USA.
[Revay, Zs.] Tech Univ Munich, Heinz Maier Leibnitz Zentrum MLZ 7, Garching, Germany.
[Sleaford, B. W.] Lawrence Livermore Natl Lab, Livermore, CA 94550 USA.
[Krticka, M.] Charles Univ Prague, Fac Math & Phys, CZ-18000 Prague, Czech Republic.
RP Matters, DA (reprint author), US Air Force, Inst Technol, Wright Patterson AFB, OH 45433 USA.
EM david.a.matters.mil@mail.mil
RI Szentmiklosi, Laszlo/F-5362-2015
OI Szentmiklosi, Laszlo/0000-0001-7747-8545
FU Defense Threat Reduction Agency Grant [HDTRA1-08-1-0014]; University of
California - Office of Science, Office of Basic Energy Sciences, of the
US Department of Energy at the Lawrence Berkeley National Laboratory
[DE-AC02-05CH11231]; Office of Science, Office of Basic Energy Sciences,
of the US Department of Energy at Lawrence Livermore National Laboratory
[DE-AC52-07NA27344]; Domestic Nuclear Detection Office of the Department
of Homeland Security; NAP VENEUS08 grant [OMFB-00184/2006]; Czech
Science Foundation [13-07117S]
FX This work was initiated under Defense Threat Reduction Agency Grant No.
HDTRA1-08-1-0014 (YSU). Later work was performed under the auspices of
the University of California, supported by the Director, Office of
Science, Office of Basic Energy Sciences, of the US Department of Energy
at the Lawrence Berkeley National Laboratory under Contract No.
DE-AC02-05CH11231, and at Lawrence Livermore National Laboratory under
Contract No. DE-AC52-07NA27344. Additional funding was provided by the
Domestic Nuclear Detection Office of the Department of Homeland
Security. Access to the Budapest PGAA facility was financially supported
by the NAP VENEUS08 grant under Contract No. OMFB-00184/2006. This work
was also supported by the Czech Science Foundation under Grant No.
13-07117S. The authors gratefully acknowledge the support of the
operations staff at the Budapest Research Reactor. D.M. thanks Dr. C.J.
Chiara for help reviewing the manuscript.
NR 70
TC 0
Z9 0
U1 8
U2 13
PU AMER PHYSICAL SOC
PI COLLEGE PK
PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA
SN 2469-9985
EI 2469-9993
J9 PHYS REV C
JI Phys. Rev. C
PD MAY 16
PY 2016
VL 93
IS 5
AR 054319
DI 10.1103/PhysRevC.93.054319
PG 19
WC Physics, Nuclear
SC Physics
GA DM3NN
UT WOS:000376253300001
ER
PT J
AU Rouhani, S
Yori, PP
Olortegui, MP
Salas, MS
Trigoso, DR
Mondal, D
Bodhidatta, L
Platts-Mills, J
Samie, A
Kabir, F
Lima, A
Babji, S
Mason, CJ
Kalam, A
Bessong, P
Ahmed, T
Mduma, E
Bhutta, ZA
Lima, I
Ramdass, R
Lang, D
George, A
Zaidi, AKM
Kang, G
Houpt, E
Kosek, MN
AF Rouhani, Saba
Yori, Pablo Penataro
Olortegui, Maribel Paredes
Salas, Mery Siguas
Trigoso, Dixner Rengifo
Mondal, Dinesh
Bodhidatta, Ladaporn
Platts-Mills, James
Samie, Amidou
Kabir, Furqan
Lima, Aldo
Babji, Sudhir
Mason, Carl J.
Kalam, Adil
Bessong, Pascal
Ahmed, Tahmeed
Mduma, Estomih
Bhutta, Zulfiqar A.
Lima, Ila
Ramdass, Rakhi
Lang, Dennis
George, Ajila
Zaidi, Anita K. M.
Kang, Gagandeep
Houpt, Eric
Kosek, Margaret N.
CA Etiology Risk Factors Interactions
TI Norovirus Infection and Acquired Immunity in 8 Countries: Results From
the MAL-ED Study
SO CLINICAL INFECTIOUS DISEASES
LA English
DT Article
DE norovirus; diarrhea; immunity
ID BIRTH COHORT; GASTROENTERITIS; METAANALYSIS; COMMUNITY; CHILDREN
AB Background. Norovirus is an important cause of childhood diarrhea. We present data from a longitudinal, multicountry study describing norovirus epidemiology during the first 2 years of life.
Methods. A birth cohort of 1457 children across 8 countries contributed 7077 diarrheal stools for norovirus testing. A subset of 199 children contributed additional asymptomatic samples (2307) and diarrheal stools (770), which were used to derive incidence rates and evaluate evidence for acquired immunity.
Results. Across sites, 89% of children experienced at least 1 norovirus infection before 24 months, and 22.7% of all diarrheal stools were norovirus positive. Severity of norovirus-positive diarrhea was comparable to other enteropathogens, with the exception of rotavirus. Incidence of genogroup II (GII) infection was higher than genogroup I and peaked at 6-11 months across sites. Undernutrition was a risk factor for symptomatic norovirus infection, with an increase in 1 standard deviation of length-for-age z score associated with a 17% reduction (odds ratio, 0.83 [95% confidence interval, .72-.97]; P = .011) in the odds of experiencing diarrhea when norovirus was present, after accounting for genogroup, rotavirus vaccine, and age. Evidence of acquired immunity was observed among GII infections only: Children with prior GII infection were found to have a 27% reduction in the hazard of subsequent infection (hazard ratio, 0.727; P = .010).
Conclusions. The high prevalence of norovirus across 8 sites in highly variable epidemiologic settings and demonstration of protective immunity for GII infections provide support for investment in vaccine development.
C1 [Rouhani, Saba; Kosek, Margaret N.] Johns Hopkins Sch Publ Hlth, Baltimore, MD USA.
[Yori, Pablo Penataro] Johns Hopkins Univ, Baltimore, MD USA.
[Olortegui, Maribel Paredes; Salas, Mery Siguas; Trigoso, Dixner Rengifo] AB PRISMA, Iquitos, Peru.
[Mondal, Dinesh; Ahmed, Tahmeed] Icddr B, Dhaka, Bangladesh.
[Bodhidatta, Ladaporn; Mason, Carl J.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
[Platts-Mills, James; Houpt, Eric] Univ Virginia, Charlottesville, VA USA.
[Samie, Amidou] Univ Venda, Thohoyandou, South Africa.
[Kabir, Furqan; Kalam, Adil; Bessong, Pascal; Bhutta, Zulfiqar A.; Zaidi, Anita K. M.] Aga Khan Univ, Naushahro Feroze, Pakistan.
[Lima, Aldo; Lima, Ila] Univ Fed Ceara, Fortaleza, Ceara, Brazil.
[Babji, Sudhir; Ramdass, Rakhi; George, Ajila; Kang, Gagandeep] Christian Med Coll & Hosp, Vellore, Tamil Nadu, India.
[Mduma, Estomih] Haydom Lutheran Hosp, Haydom, Tanzania.
[Lang, Dennis] Fdn Natl Inst Hlth, Bethesda, MD USA.
RP Kosek, MN (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Rm E5608,615 N Wolfe St, Baltimore, MD 21205 USA.
EM mkosek@jhu.edu
RI Strand, Tor/D-9836-2016
OI Strand, Tor/0000-0002-4038-151X
NR 15
TC 2
Z9 2
U1 1
U2 1
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1058-4838
EI 1537-6591
J9 CLIN INFECT DIS
JI Clin. Infect. Dis.
PD MAY 15
PY 2016
VL 62
IS 10
BP 1210
EP 1220
DI 10.1093/cid/ciw072
PG 11
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA DP3YM
UT WOS:000378432100004
PM 27013692
ER
PT J
AU Stefan, CP
Koehler, JW
Minogue, TD
AF Stefan, Christopher P.
Koehler, Jeffrey W.
Minogue, Timothy D.
TI Targeted next-generation sequencing for the detection of ciprofloxacin
resistance markers using molecular inversion probes
SO SCIENTIFIC REPORTS
LA English
DT Article
ID POLYMERASE-CHAIN-REACTION; INFECTIOUS-DISEASES; YERSINIA-PESTIS;
CLINICAL MICROBIOLOGY; ANTIBIOTIC-RESISTANCE; BACILLUS-ANTHRACIS;
BIOTHREAT AGENTS; HIGH-THROUGHPUT; AMPLIFICATION; DNA
AB Antibiotic resistance (AR) is an epidemic of increasing magnitude requiring rapid identification and profiling for appropriate and timely therapeutic measures and containment strategies. In this context, ciprofloxacin is part of the first-line of countermeasures against numerous high consequence bacteria. Significant resistance can occur via single nucleotide polymorphisms (SNP) and deletions within ciprofloxacin targeted genes. Ideally, use of ciprofloxacin would be prefaced with AR determination to avoid overuse or misuse of the antibiotic. Here, we describe the development and evaluation of a panel of 44 single-stranded molecular inversion probes (MIPs) coupled to next-generation sequencing (NGS) for the detection of genetic variants known to confer ciprofloxacin resistance in Bacillus anthracis, Yersinia pestis, and Francisella tularensis. Sequencing results demonstrate MIPs capture and amplify targeted regions of interest at significant levels of coverage. Depending on the genetic variant, limits of detection (LOD) for high-throughput pooled sequencing ranged from approximately 300-1800 input genome copies. LODs increased 10-fold in the presence of contaminating human genome DNA. In addition, we show that MIPs can be used as an enrichment step with high resolution melt (HRM) real-time PCR which is a sensitive assay with a rapid time-to-answer. Overall, this technology is a multiplexable upfront enrichment applicable with multiple downstream molecular assays for the detection of targeted genetic regions.
C1 [Stefan, Christopher P.; Koehler, Jeffrey W.; Minogue, Timothy D.] US Army, Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA.
RP Minogue, TD (reprint author), US Army, Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA.
EM timothy.d.minogue.civ@mail.mil
OI Koehler, Jeffrey/0000-0003-3225-6599
FU Defense Threat Reduction Agency (DTRA)
FX This work was supported by the Defense Threat Reduction Agency (DTRA).
The opinions, interpretations, conclusions, and recommendations
contained herein are those of the authors and are not necessarily
endorsed by the US Army.
NR 45
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Z9 1
U1 4
U2 10
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAY 13
PY 2016
VL 6
AR 25904
DI 10.1038/srep25904
PG 12
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DL6SP
UT WOS:000375769700001
PM 27174456
ER
PT J
AU Newburgh, GA
Dubinskii, M
AF Newburgh, G. A.
Dubinskii, M.
TI High power eye-safe Er3+:YVO4 laser diode-pumped at 976 nm
SO ELECTRONICS LETTERS
LA English
DT Article
DE erbium; yttrium compounds; semiconductor lasers; optical pumping;
diffraction gratings; slabs; laser cavity resonators; light
polarisation; YVO4:Er3+; size 10 mm; wavelength 970 nm to 980 nm;
wavelength 1603 nm; quasicontinuous wave regime; -polarisation;
sigma-polarisation; laser cavity axis; c-axis; slab; near diffraction
limited beam quality; single crystal; laser diode-pumping; high power
eye-safe laser
ID 1.6 MU-M; CRYSTALS; RANGE
AB The performance of an eye-safe laser based on a Er-doped orthovanadate (Er:YVO4) single crystal, diode-pumped at 976 nm (I-4(15/2) I-4(11/2) transition) and operating at 1603 nm (I-4(13/2) I-4(15/2) transition) with near diffraction limited beam quality is reported. A 10 mm long Er3+:YVO4 slab, cut with its c-axis perpendicular to the laser cavity axis, was pumped in sigma-polarisation and lased in -polarisation. The laser operated in a quasi-continuous wave regime with nearly 9 W output power, and with a slope efficiency of about 39% with respect to absorbed power. This is believed to be the highest efficiency and highest power achieved from an Er3+:YVO4 laser pumped in the 970-980 nm absorption band.
C1 [Newburgh, G. A.; Dubinskii, M.] US Army, Res Lab, Adelphi Lab Ctr, Sensors & Elect Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
RP Newburgh, GA (reprint author), US Army, Res Lab, Adelphi Lab Ctr, Sensors & Elect Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM george.a.newburgh.civ@mail.mil
NR 13
TC 0
Z9 0
U1 12
U2 13
PU INST ENGINEERING TECHNOLOGY-IET
PI HERTFORD
PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD SG1 2AY, ENGLAND
SN 0013-5194
EI 1350-911X
J9 ELECTRON LETT
JI Electron. Lett.
PD MAY 12
PY 2016
VL 52
IS 10
DI 10.1049/el.2016.0252
PG 2
WC Engineering, Electrical & Electronic
SC Engineering
GA DM1VW
UT WOS:000376136000043
ER
PT J
AU Ayangeakaa, AD
Garg, U
Petrache, CM
Guo, S
Zhao, PW
Matta, JT
Nayak, BK
Patel, D
Janssens, RVF
Carpenter, MP
Chiara, CJ
Kondev, FG
Lauritsen, T
Seweryniak, D
Zhu, S
Ghugre, SS
Palit, R
AF Ayangeakaa, A. D.
Garg, U.
Petrache, C. M.
Guo, S.
Zhao, P. W.
Matta, J. T.
Nayak, B. K.
Patel, D.
Janssens, R. V. F.
Carpenter, M. P.
Chiara, C. J.
Kondev, F. G.
Lauritsen, T.
Seweryniak, D.
Zhu, S.
Ghugre, S. S.
Palit, R.
TI In-beam spectroscopy of medium- and high-spin states in Ce-133
SO PHYSICAL REVIEW C
LA English
DT Article
ID COINCIDENCE DATA SETS; ROTATIONAL BANDS; LIFETIME MEASUREMENTS; MAGNETIC
ROTATION; COLLECTIVITY
AB Medium and high-spin states in Ce-133 were investigated using the Cd-116(Ne-22, 5n) reaction and the Gammasphere array. The level scheme was extended up to an excitation energy of similar to 22.8 MeV and spin 93/2 (h) over bar. Eleven bands of quadrupole transitions and two new dipole bands are identified. The connections to low-lying states of the previously known, high-spin triaxial bands were firmly established, thus fixing the excitation energy and, in many cases, the spin parity of the levels. Based on comparisons with cranked Nilsson-Strutinsky calculations and tilted axis cranking covariant density functional theory, it is shown that all observed bands are characterized by pronounced triaxiality. Competing multiquasiparticle configurations are found to contribute to a rich variety of collective phenomena in this nucleus.
C1 [Ayangeakaa, A. D.; Garg, U.; Matta, J. T.; Nayak, B. K.; Patel, D.] Univ Notre Dame, Dept Phys, Notre Dame, IN 46556 USA.
[Petrache, C. M.; Guo, S.] Univ Paris Saclay, CNRS, IN2P3, Ctr Sci Nucl & Sci Mat, Bat 104-108, F-91405 Orsay, France.
[Ayangeakaa, A. D.; Zhao, P. W.; Janssens, R. V. F.; Carpenter, M. P.; Chiara, C. J.; Lauritsen, T.; Seweryniak, D.; Zhu, S.] Argonne Natl Lab, Div Phys, Argonne, IL 60439 USA.
[Chiara, C. J.] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA.
[Kondev, F. G.] Argonne Natl Lab, Nucl Engn Div, 9700 S Cass Ave, Argonne, IL 60439 USA.
[Ghugre, S. S.] UGC DAE Consortium Sci Res, Kolkata 700098, India.
[Palit, R.] Tata Inst Fundamental Res, Homi Bhabha Rd, Bombay 400005, Maharashtra, India.
[Palit, R.] Univ Notre Dame, Joint Inst Nucl Astrophys, Notre Dame, IN 46556 USA.
[Matta, J. T.] Oak Ridge Natl Lab, Div Phys, Oak Ridge, TN 37830 USA.
[Nayak, B. K.] Bhabha Atom Res Ctr, Div Nucl Phys, Bombay 400085, Maharashtra, India.
[Patel, D.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
[Chiara, C. J.] US Army Res Lab, Adelphi, MD 20783 USA.
RP Ayangeakaa, AD (reprint author), Univ Notre Dame, Dept Phys, Notre Dame, IN 46556 USA.; Ayangeakaa, AD (reprint author), Argonne Natl Lab, Div Phys, Argonne, IL 60439 USA.
RI Zhao, Pengwei/F-9107-2010; Palit, Rudrajyoti/F-5185-2012
OI Zhao, Pengwei/0000-0001-8243-2381;
FU U.S. National Science Foundation [PHY07-58100, PHY-0822648, PHY-1068192,
PHY-1419765]; U.S. Department of Energy, Office of Nuclear Physics
[DE-FG02-94ER40834, DE-AC02-06CH11357]
FX C.M.P. expresses his gratitude to Prof. I. Ragnarsson for providing the
CNS codes, for the training on how to use them, and for enlightening
comments on the theoretical interpretation of the results. This work was
supported in part by the U.S. National Science Foundation Grants No.
PHY07-58100, No. PHY-0822648, No. PHY-1068192, and No. PHY-1419765, and
the U.S. Department of Energy, Office of Nuclear Physics, under Grant
No. DE-FG02-94ER40834 (UM) and Contract No. DE-AC02-06CH11357 (ANL).
This research used resources of ANL's ATLAS facility, which is a DOE
Office of Science User Facility.
NR 30
TC 2
Z9 2
U1 2
U2 3
PU AMER PHYSICAL SOC
PI COLLEGE PK
PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA
SN 2469-9985
EI 2469-9993
J9 PHYS REV C
JI Phys. Rev. C
PD MAY 12
PY 2016
VL 93
IS 5
AR 054317
DI 10.1103/PhysRevC.93.054317
PG 19
WC Physics, Nuclear
SC Physics
GA DL9YN
UT WOS:000375999500002
ER
PT J
AU Tenan, MS
AF Tenan, Matthew S.
TI A Statistical Method and Tool to Account for Indirect Calorimetry
Differential Measurement Error in a Single-Subject Analysis
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE exercise testing; VO2; indirect calorimetry; research methods; cost of
transport
ID VARIABILITY; INFERENCE; SYSTEMS
AB Indirect calorimetry and oxygen consumption (VO2) are accepted tools in human physiology research. It has been shown that indirect calorimetry systems exhibit differential measurement error, where the error of a device is systematically different depending on the volume of gas flow. Moreover, systems commonly report multiple decimal places of precision, giving the clinician a false sense of device accuracy. The purpose of this manuscript is to demonstrate the use of a novel statistical tool which models the reliability of two specific indirect calorimetry systems, Douglas bag and Parvomedics 2400 TrueOne, as univariate normal distributions and implements the distribution overlapping coefficient to determine the likelihood that two VO2 measures are the same. A command line implementation of the tool is available for the R programming language as well as a web-based graphical user interface (GUI). This tool is valuable for clinicians performing a single-subject analysis as well as researchers interested in determining if their observed differences exceed the error of the device.
C1 [Tenan, Matthew S.] US Army Res Lab, Human Res & Engn Directorate, Integrated Capabil Enhancement Branch, Aberdeen, MD USA.
RP Tenan, MS (reprint author), US Army Res Lab, Human Res & Engn Directorate, Integrated Capabil Enhancement Branch, Aberdeen, MD USA.
EM matthew.s.tenan.civ@mail.mil
NR 19
TC 0
Z9 0
U1 2
U2 2
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015,
SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD MAY 11
PY 2016
VL 7
AR 172
DI 10.3389/fphys.2016.00172
PG 6
WC Physiology
SC Physiology
GA DL3SH
UT WOS:000375553100001
PM 27242546
ER
PT J
AU Norberg, SA
Johnsen, E
Kushner, MJ
AF Norberg, Seth A.
Johnsen, Eric
Kushner, Mark J.
TI Helium atmospheric pressure plasma jets interacting with wet cells:
delivery of electric fields
SO JOURNAL OF PHYSICS D-APPLIED PHYSICS
LA English
DT Article
DE plasma medicine; plasma liquid interactions; atmospheric pressure
plasma; plasma jets; electroporation; electric fields and cells;
modeling
ID DOMAIN DIELECTRIC-SPECTROSCOPY; CANCER-CELLS; PULSES; ELECTROPORATION;
TISSUES; DEATH
AB The use of atmospheric pressure plasma jets (APPJs) in plasma medicine have produced encouraging results in wound treatment, surface sterilization, deactivation of bacteria, and treatment of cancer cells. It is known that many of the reactive oxygen and nitrogen species produced by the APPJ are critical to these processes. Other key components to treatment include the ion and photon fluxes, and the electric fields produced in cells by the ionization wave of the APPJ striking in the vicinity of the cells. These relationships are often complicated by the cells being covered by a thin liquid layer-wet cells. In this paper, results from a computational investigation of the interaction of APPJs with tissue beneath a liquid layer are discussed. The emphasis of this study is the delivery of electric fields by an APPJ sustained in He/O-2 = 99.8/0.2 flowing into humid air to cells lying beneath water with thickness of 200 mu m. The water layer represents the biological fluid typically covering tissue during treatment. Three voltages were analyzed-two that produce a plasma effluent that touches the surface of the water layer and one that does not touch. The effect of the liquid layer thickness, 50 mu m to 1 mm, was also examined. Comparisons were made of the predicted intracellular electric fields to those thresholds used in the field of bioelectronics.
C1 [Norberg, Seth A.; Johnsen, Eric] Univ Michigan, Dept Mech Engn, 2350 Hayward St, Ann Arbor, MI 48109 USA.
[Kushner, Mark J.] Univ Michigan, Dept Elect Engn & Comp Sci, 1301 Beal Ave, Ann Arbor, MI 48109 USA.
[Norberg, Seth A.] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA.
RP Kushner, MJ (reprint author), Univ Michigan, Dept Elect Engn & Comp Sci, 1301 Beal Ave, Ann Arbor, MI 48109 USA.
EM norbergs@umich.edu; ejohnsen@umich.edu; mjkush@umich.edu
FU Department of Energy Office of Fusion Energy Science [DE-SC0001319];
National Science Foundation [CHE-1124724]
FX This work was supported by the Department of Energy Office of Fusion
Energy Science (DE-SC0001319) and the National Science Foundation
(CHE-1124724).
NR 46
TC 1
Z9 1
U1 7
U2 23
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0022-3727
EI 1361-6463
J9 J PHYS D APPL PHYS
JI J. Phys. D-Appl. Phys.
PD MAY 11
PY 2016
VL 49
IS 18
AR 185201
DI 10.1088/0022-3727/49/18/185201
PG 16
WC Physics, Applied
SC Physics
GA DK9MU
UT WOS:000375255300015
ER
PT J
AU Veysset, D
Hsieh, AJ
Kooi, S
Maznev, AA
Masser, KA
Nelson, KA
AF Veysset, David
Hsieh, Alex J.
Kooi, Steven
Maznev, Alexei A.
Masser, Kevin A.
Nelson, Keith A.
TI Dynamics of supersonic microparticle impact on elastomers revealed by
real-time multi-frame imaging
SO SCIENTIFIC REPORTS
LA English
DT Article
ID POLY(URETHANE UREA) ELASTOMERS; STRESS-STRAIN BEHAVIOR; SOLID PARTICLE
IMPACT; MECHANICAL-PROPERTIES; UNFILLED ELASTOMERS; MOLECULAR-DYNAMICS;
RATE DEFORMATION; EROSION; POLYURETHANE; MICROSTRUCTURE
AB Understanding high-velocity microparticle impact is essential for many fields, from space exploration to medicine and biology. Investigations of microscale impact have hitherto been limited to postmortem analysis of impacted specimens, which does not provide direct information on the impact dynamics. Here we report real-time multi-frame imaging studies of the impact of 7 mu m diameter glass spheres traveling at 700-900 m/s on elastomer polymers. With a poly(urethane urea) (PUU) sample, we observe a hyperelastic impact phenomenon not seen on the macroscale: a microsphere undergoes a full conformal penetration into the specimen followed by a rebound which leaves the specimen unscathed. The results challenge the established interpretation of the behaviour of elastomers under high-velocity impact.
C1 [Veysset, David; Hsieh, Alex J.; Kooi, Steven; Maznev, Alexei A.; Nelson, Keith A.] MIT, Inst Soldier Nanotechnol, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
[Veysset, David; Maznev, Alexei A.; Nelson, Keith A.] MIT, Dept Chem, Cambridge, MA 02139 USA.
[Hsieh, Alex J.; Masser, Kevin A.] US Army, Res Lab, RDRL WMM G, Aberdeen Proving Ground, MD 21005 USA.
RP Veysset, D (reprint author), MIT, Inst Soldier Nanotechnol, 77 Massachusetts Ave, Cambridge, MA 02139 USA.; Veysset, D (reprint author), MIT, Dept Chem, Cambridge, MA 02139 USA.
EM dveysset@mit.edu
RI Veysset, David/Q-5566-2016
OI Veysset, David/0000-0003-4473-1983
FU U.S. Army through the Institute for Soldier Nanotechnologies; U.S. Army
Research Office [W911NF-13-D-0001]; Office of Naval Research DURIP Grant
[N00014-13-1-0676]
FX This work was supported by the U.S. Army through the Institute for
Soldier Nanotechnologies. Funding was provided by the U.S. Army Research
Office, under Grant W911NF-13-D-0001. Support was also provided through
Office of Naval Research DURIP Grant No. N00014-13-1-0676.
NR 36
TC 0
Z9 0
U1 2
U2 7
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAY 9
PY 2016
VL 6
AR 25577
DI 10.1038/srep25577
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DL2AP
UT WOS:000375435100001
PM 27156501
ER
PT J
AU Wang, YS
Hocut, CM
Hoch, SW
Creegan, E
Fernando, HJS
Whiteman, CD
Felton, M
Huynh, G
AF Wang, Yansen
Hocut, Christopher M.
Hoch, Sebastian W.
Creegan, Edward
Fernando, Harindra J. S.
Whiteman, C. David
Felton, Melvin
Huynh, Giap
TI Triple Doppler wind lidar observations during the mountain terrain
atmospheric modeling and observations field campaign
SO JOURNAL OF APPLIED REMOTE SENSING
LA English
DT Article
DE triple Doppler wind lidar observation; atmospheric turbulence
measurement; atmospheric boundary layer; Doppler lidar and sonic
anemometer comparison
ID BOUNDARY-LAYER; SONIC ANEMOMETER; COMPLEX TERRAIN; SINGLE-DOPPLER;
TURBULENCE; DISPERSION; RETRIEVAL; CASES-99; ENERGY
AB Coordinated triple Doppler wind lidars (DWLs) were employed during the Mountain Terrain Atmospheric Modeling and Observations (MATERHORN) program field campaign to observe turbulent winds in the mountain terrain atmospheric boundary layer (ABL). The feasibility of observing large turbulent eddies was investigated by pointing three DWL at an intersecting probe volume adjoining a sonic anemometer mounted on the top of a meteorological tower. The time series and spectra of the sonic anemometer measurement were compared with the lidars. The lidar radial velocities closely followed those of the sonic anemometer, both in time and in the low frequency spectral domain, suggesting that the DWL technique is suitable for observing large turbulent eddies in the ABL. In addition, coordinated scanning triple DWL were used to directly measure the three-dimensional wind vectors, thus circumventing the assumptions required in using single or dual lidar deployments for full velocity measurements. The scanning triple lidar results were in satisfactory agreement with data from tower-based sonic anemometers. Notwithstanding, because of the difficulty of obtaining temporal and spatial synchronizations of the three lidars, the data were scant since a large amount of data had to be rejected in postprocessing. This difficulty is surmountable in the future by employing a robust control system for coordinated scanning. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
C1 [Wang, Yansen; Felton, Melvin; Huynh, Giap] US Army, Res Lab, Adelphi, MD 20783 USA.
[Hocut, Christopher M.; Creegan, Edward] US Army, Res Lab, White Sands Missile Range, NM 88002 USA.
[Hocut, Christopher M.; Fernando, Harindra J. S.] Univ Notre Dame, Dept Civil & Environm Engn & Earth Sci, Notre Dame, IN 46556 USA.
[Hoch, Sebastian W.; Whiteman, C. David] Univ Utah, Dept Atmospher Sci, Salt Lake City, UT 84112 USA.
RP Wang, YS (reprint author), US Army, Res Lab, Adelphi, MD 20783 USA.
EM yansen.wang.civ@mail.mil
FU Office of Naval Research Award [N00014-11-1-0709]; mountain terrain
atmospheric modeling and observations (MATERHORN) program; Air Force
Weather Agency
FX This overall research program was funded by Office of Naval Research
Award Grant No. N00014-11-1-0709 and mountain terrain atmospheric
modeling and observations (MATERHORN) program. The ARL part of this
research was in part supported by the Air Force Weather Agency as an
addendum to DOD MATERHORN funding. We thank colleagues from Dugway
Proving Ground, University of Norte Dame, and University of Utah for
their help and support during the field campaigns.
NR 40
TC 1
Z9 1
U1 1
U2 3
PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA
SN 1931-3195
J9 J APPL REMOTE SENS
JI J. Appl. Remote Sens.
PD MAY 5
PY 2016
VL 10
AR 026015
DI 10.1117/1.JRS.10.026015
PG 14
WC Environmental Sciences; Remote Sensing; Imaging Science & Photographic
Technology
SC Environmental Sciences & Ecology; Remote Sensing; Imaging Science &
Photographic Technology
GA DL5FV
UT WOS:000375663600001
ER
PT J
AU Borstad, GM
Batyrev, IG
Ciezak-Jenkins, JA
AF Borstad, Gustav M.
Batyrev, Iskander G.
Ciezak-Jenkins, Jennifer A.
TI Cyanoacetohydrazide under Pressure: Chemical Changes in a
Hydrogen-Bonded Material
SO JOURNAL OF PHYSICAL CHEMISTRY A
LA English
DT Article
ID ENERGETIC MATERIAL; RAMAN-SCATTERING; POLAR MOLECULE; NITROGEN;
CARBOHYDRAZIDE; ACETONITRILE; CRYSTALS; TRANSFORMATION; DIFFRACTION;
TRANSITION
AB Cyanoacetohydrazide (CAH, C3H5N3O) has been studied under pressure using diamond anvil cell techniques. CAH was characterized using Raman spectroscopy to 30 GPa and synchrotron X-ray diffraction to 45 GPa. The Raman spectra of CAH show reasonable qualitative agreement with first-principle calculations. The X-ray data reveal that CAH maintains its monoclinic structure to approximately 22 GPa with a density change of 12% over this range. Near 22 GPa, the Raman modes and most of the X-ray diffraction peaks disappear. These pressure-induced changes are irreversible upon the release of pressure, and the transformed sample can be recovered to ambient pressure. The recovered sample is photosensitive and shows reaction even at low laser powers of 10 mW at 532 nm. The paper concludes with observations of the roles of hydrogen bonding, molecular configurations, and the behavior of the cyano group in the pressure-induced changes in CAH.
C1 [Borstad, Gustav M.; Batyrev, Iskander G.; Ciezak-Jenkins, Jennifer A.] US Army Res Lab, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA.
RP Ciezak-Jenkins, JA (reprint author), US Army Res Lab, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA.
EM Jennifer.a.ciezak-jenkins.civ@mail.mil
FU Office of Science, Office of Basic Energy Sciences of the U.S.
Department of Energy [DE-AC02-05CH11231]
FX During this project, coauthor G.M.B. was supported in part by an
appointment to the Postdoctoral Research Program at the US Army Research
Laboratory administered by the Oak Ridge Associated Universities.
Portions of this work were performed at the Advanced Light Source, which
is supported by the Director, Office of Science, Office of Basic Energy
Sciences, of the U.S. Department of Energy under Contract No.
DE-AC02-05CH11231. Finally, we also acknowledge the insightful
contributions of two anonymous reviewers.
NR 43
TC 0
Z9 0
U1 7
U2 13
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1089-5639
J9 J PHYS CHEM A
JI J. Phys. Chem. A
PD MAY 5
PY 2016
VL 120
IS 17
BP 2712
EP 2719
DI 10.1021/acqs.jpca.5b11954
PG 8
WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical
SC Chemistry; Physics
GA DL4TX
UT WOS:000375631500012
PM 27104289
ER
PT J
AU Sirk, TW
Karim, M
Lenhart, JL
Andzelm, JW
Khare, R
AF Sirk, Timothy W.
Karim, Mir
Lenhart, Joseph L.
Andzelm, Jan W.
Khare, Rajesh
TI Bi-modal polymer networks: Viscoelasticity and mechanics from molecular
dynamics simulation
SO POLYMER
LA English
DT Article
DE Molecular dynamics; Mixed network; Viscoelasticity; Epoxy; High
strain-rate
ID CROSS-LINKED EPOXY; EFFICIENT GENERATION; AM1-BCC MODEL; FORCE-FIELD;
DEFORMATION
AB The high strain-rate rheological and mechanical properties of bi-modal epoxy polymer networks were characterized using molecular dynamics simulation. The complex Young's modulus was found by applying a cyclic sinusoidal strain over a wide range of temperatures spanning the glass transition. The non-linear stress response was studied in the glass transition region using uni-axial deformation. We discuss special considerations in computing viscoelastic properties at the high strain-rates available to molecular dynamics. As in experimental studies, the complex modulus is shown to be a function of the network composition and strain rate. However, the high strain-rate simulations performed here predict the existence of broad peaks in the temperature-dependent loss modulus and slow relaxation of the storage modulus. In general, it is observed that network compositions with larger amounts of short, stiff 4,4'-methylenebis(cyclohexylamine) (MCA) cross-linkers lead to an increase in the mechanical glass transition temperature as well as the breadth of the glass transition compared to longer, more flexible poly(oxypropylene) diamine (POP) cross-linkers. When the networks of any composition were deformed beyond the linear region, the stress response displayed a plateau that was associated with the extension of network chains. Published by Elsevier Ltd.
C1 [Sirk, Timothy W.; Lenhart, Joseph L.; Andzelm, Jan W.] US Army Res Lab, Macromol Sci & Technol Branch, Aberdeen Proving Ground, MD USA.
[Karim, Mir; Khare, Rajesh] Texas Tech Univ, Dept Chem Engn, Box 43121, Lubbock, TX 79409 USA.
RP Sirk, TW (reprint author), US Army Res Lab, Macromol Sci & Technol Branch, Aberdeen Proving Ground, MD USA.; Khare, R (reprint author), Texas Tech Univ, Dept Chem Engn, Box 43121, Lubbock, TX 79409 USA.
EM tim.sirk@us.army.mil; rajesh.khare@ttu.edu
RI Khare, Rajesh/J-2079-2014
OI Khare, Rajesh/0000-0002-8859-766X
FU U.S. Army/Battelle Memorial Institute [US0010000287704]
FX The work of MK and RK was supported by U.S. Army/Battelle Memorial
Institute contract number US0010000287704.
NR 29
TC 4
Z9 4
U1 8
U2 31
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0032-3861
EI 1873-2291
J9 POLYMER
JI Polymer
PD MAY 4
PY 2016
VL 90
BP 178
EP 186
DI 10.1016/j.polymer.2016.03.024
PG 9
WC Polymer Science
SC Polymer Science
GA DI2CR
UT WOS:000373303800019
ER
PT J
AU Yost, EE
Stanek, J
DeWoskin, RS
Burgoon, LD
AF Yost, Erin E.
Stanek, John
DeWoskin, Robert S.
Burgoon, Lyle D.
TI Overview of Chronic Oral Toxicity Values for Chemicals Present in
Hydraulic Fracturing Fluids, Flowback, and Produced Waters
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID NATURAL-GAS OPERATIONS; SHALE; PENNSYLVANIA; IMPACTS
AB Concerns have been raised about potential public health effects that may arise if hydraulic fracturing related chemicals were to impact drinking water resources. This study presents an overview of the chronic oral toxicity values-specifically, chronic oral reference values (RfVs) for noncancer effects, and oral slope factors (OSFs) for cancer-that are available for a list of 1173 chemicals that the United States (U.S.) Environmental Protection Agency (EPA) identified as being associated with hydraulic fracturing, including 1076 chemicals used in hydraulic fracturing fluids and 134 chemicals detected in flowback or produced waters from hydraulically fractured wells. The EPA compiled RfVs and OSFs using six governmental and intergovernmental data sources. Ninety (8%) of the 1076 chemicals reported in hydraulic fracturing fluids and 83 (62%) of the 134 chemicals reported in flowback/produced water had a chronic oral RfV or OSF available from one or more of the six sources. Furthermore, of the 36 chemicals reported in hydraulic fracturing fluids in at least 10% of wells nationwide (identified from EPA's analysis of the FracFocus Chemical Disclosure Registry 1.0), 8 chemicals (22%) had an available chronic oral RfV. The lack of chronic oral RfVs and OSFs for the majority of these chemicals highlights the significant knowledge gap that exists to assess the potential human health hazards associated with hydraulic fracturing.
C1 [Yost, Erin E.] US EPA, Oak Ridge Inst Sci & Educ ORISE Res Participat, Natl Ctr Environm Assessment, Res Triangle Pk, Res Triangle Pk, NC 27711 USA.
[Yost, Erin E.; Stanek, John; DeWoskin, Robert S.; Burgoon, Lyle D.] US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Res Triangle Pk, Res Triangle Pk, NC 27711 USA.
[DeWoskin, Robert S.] etioLogic LLC, Durham, NC 27712 USA.
[Burgoon, Lyle D.] US Army Engineer Res & Dev Ctr, Environm Lab, Res Triangle Pk, Res Triangle Pk, NC 27711 USA.
RP Burgoon, LD (reprint author), US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Res Triangle Pk, Res Triangle Pk, NC 27711 USA.
EM Lyle.D.Burgoon@usace.army.mil
OI Burgoon, Lyle/0000-0003-4977-5352
NR 37
TC 6
Z9 6
U1 16
U2 40
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD MAY 3
PY 2016
VL 50
IS 9
BP 4788
EP 4797
DI 10.1021/acs.est.5b04645
PG 10
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA DL3GE
UT WOS:000375521400023
PM 27050380
ER
PT J
AU Knorr, DB
Tran, NT
Gaskell, KJ
Orlicki, JA
Woicik, JC
Jaye, C
Fischer, DA
Lenhart, JL
AF Knorr, Daniel B., Jr.
Tran, Ngon T.
Gaskell, Karen J.
Orlicki, Joshua A.
Woicik, Joseph C.
Jaye, Cherno
Fischer, Daniel A.
Lenhart, Joseph L.
TI Synthesis and Characterization of
Aminopropyltriethoxysilane-Polydopamine Coatings
SO LANGMUIR
LA English
DT Article
ID RAY PHOTOELECTRON-SPECTROSCOPY; GAMMA-AMINOPROPYLTRIETHOXYSILANE;
MULTIFUNCTIONAL COATINGS; AQUEOUS-SOLUTION; CROSS-LINKING; THIN-FILMS;
DOPAMINE; SURFACES; CATECHOL; SILICON
AB Polydopamine coatings are of interest due to the fact that they can promote adhesion to a broad range of materials and can enable a variety of applications. However, the polydopamine-substrate interaction is often noncovalent. To broaden the potential applications of polydopamine, we show the incorporation of 3-aminopropyltriethoxysilane (APTES), a traditional coupling agent capable of covalent bonding to a broad range of organic and inorganic surfaces, into polydopamine coatings. High energy X-ray photoelectron spectroscopy (HE-XPS), conventional XPS, near-edge X-ray absorption fine structure (NEXAFS), Fourier transform infrared-attenuated total reflectance (FTIR-ATR), and ellipsometry measurements were used to investigate changes in coating chemistry and thickness, which suggest covalent incorporation of APTES into polydopamine. These coatings can be deposited either in Tris buffer or by using an aqueous APTES solution as a buffer without Tris. APTES dopamine hydrochloride deposition from solutions with molar ratios between 0:1 and 10:1 allowed us to control the coating composition across a broad range.
C1 [Knorr, Daniel B., Jr.; Tran, Ngon T.; Orlicki, Joshua A.; Lenhart, Joseph L.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Gaskell, Karen J.] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA.
[Woicik, Joseph C.; Jaye, Cherno; Fischer, Daniel A.] Natl Inst Stand & Technol, Mat Measurement Lab, Gaithersburg, MD 20899 USA.
RP Knorr, DB; Lenhart, JL (reprint author), US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM daniel.knorr.civ@mail.mil; joseph.l.lenhart.civ@mail.mil
FU U.S. Army Research Laboratory
FX Funding for this work was provided by the U.S. Army Research Laboratory.
NR 69
TC 3
Z9 3
U1 14
U2 44
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0743-7463
J9 LANGMUIR
JI Langmuir
PD MAY 3
PY 2016
VL 32
IS 17
BP 4370
EP 4381
DI 10.1021/acs.langmuir.6b00531
PG 12
WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science,
Multidisciplinary
SC Chemistry; Materials Science
GA DL3FY
UT WOS:000375520800027
PM 27055091
ER
PT J
AU Nath-Chowdhury, M
Sangaralingam, M
Bastien, P
Ravel, C
Pratlong, F
Mendez, J
Libman, M
Ndao, M
AF Nath-Chowdhury, Milli
Sangaralingam, Mugundhine
Bastien, Patrick
Ravel, Christophe
Pratlong, Francine
Mendez, Juan
Libman, Michael
Ndao, Momar
TI Real-time PCR using FRET technology for Old World cutaneous
leishmaniasis species differentiation
SO PARASITES & VECTORS
LA English
DT Article
DE qPCR; Real-time PCR; Leishmania; Cutaneous; Diagnosis; FRET; Melting
curve
ID POLYMERASE-CHAIN-REACTION; MELTING-CURVE ANALYSIS; CYSTEINE
PROTEINASE-B; MAJOR-LIKE; IDENTIFICATION; ASSAY; DIAGNOSIS;
AMPLIFICATION; INFECTION; TRAVELERS
AB Background: Recently, there has been a re-emergence of cutaneous leishmaniasis in endemic countries and an increase in imported cases in non-endemic countries by travelers, workers, expatriates, immigrants, and military force personnel. Old World cutaneous leishmaniasis is caused primarily by Leishmania major, L. tropica and L. aethiopica. Despite their low sensitivity, diagnosis traditionally includes microscopic and histopathological examinations, and in vitro cultivation. Several conventional PCR techniques have been developed for species identification, which are time-consuming and labour-intensive. Real-time PCR using SYBR green dye, although provides rapid detection, may generate false positive signals. Therefore, a rapid and easy method such as a FRET-based real-time PCR would improve not only the turn-around time of diagnosing Old World cutaneous Leishmania species but will also increase its specificity and sensitivity.
Methods: A FRET-based real-time PCR assay which amplifies the cathepsin L-like cysteine protease B gene encoding a major Leishmania antigen was developed to differentiate L. major, L. tropica, and L. aethiopica in one single step using one set of primers and probes. Assay performance was tested on cutaneous and visceral strains of Leishmania parasite cultures and isolates of other protozoan parasites as well as human biopsy specimen.
Results: The assay readily differentiates between the three Old World cutaneous leishmaniasis species based on their melting curve characteristics. A single Tm at 55.2 +/- 0.5 degrees C for L. aethiopica strains was distinguished from a single Tm at 57.4 +/- 0.2 degrees C for L. major strains. A double curve with melting peaks at 66.6 +/- 0.1 degrees C and 48.1 +/- 0.5 degrees C or 55.8 +/- 0.6 degrees C was observed for all L. tropica strains. The assay was further tested on biopsy specimens, which showed 100 % agreement with results obtained from isoenzyme electrophoresis and Sanger sequencing.
Conclusion: Currently, there are no published data on real-time PCR using FRET technology to differentiate between Old World cutaneous Leishmania species. In summary, our assay based on specific hybridization addresses the limitations of previous PCR technology and provides a single step, reliable method of species identification and rapid diagnostic applications.
C1 [Nath-Chowdhury, Milli; Sangaralingam, Mugundhine; Libman, Michael; Ndao, Momar] McGill Univ, Ctr Hlth, Res Inst, Natl Reference Ctr Parasitol, Montreal, PQ, Canada.
[Bastien, Patrick; Ravel, Christophe; Pratlong, Francine] Ctr Hosp Reg Univ Montpellier, Ctr Natl Reference Leishmanioses, Dept Parasitol Mycol, Montpellier, France.
[Bastien, Patrick; Ravel, Christophe; Pratlong, Francine] Univ Montpellier I, Fac Med, CNRS, UMR 5290,IRD 224,UM1 & 2,MIVEGEC, Montpellier, France.
[Mendez, Juan] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA.
[Libman, Michael; Ndao, Momar] McGill Univ, JD MacLean Ctr Trop Dis, Montreal, PQ, Canada.
RP Ndao, M (reprint author), McGill Univ, Ctr Hlth, Res Inst, Natl Reference Ctr Parasitol, Montreal, PQ, Canada.; Ndao, M (reprint author), McGill Univ, JD MacLean Ctr Trop Dis, Montreal, PQ, Canada.
EM momar.ndao@mcgill.ca
FU Public Health Agency of Canada/National Microbiology Laboratory [MOA
4500299739]; Foundation of the Montreal General Hospital; Research
Institute of the McGill University Health Centre
FX The National Reference Centre for Parasitology is supported by Public
Health Agency of Canada/National Microbiology Laboratory grant MOA
4500299739, the Foundation of the Montreal General Hospital and the
Research Institute of the McGill University Health Centre.
NR 52
TC 0
Z9 0
U1 5
U2 7
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1756-3305
J9 PARASITE VECTOR
JI Parasites Vectors
PD MAY 3
PY 2016
VL 9
AR 255
DI 10.1186/s13071-016-1531-4
PG 11
WC Parasitology
SC Parasitology
GA DL7QD
UT WOS:000375834300001
PM 27141967
ER
PT J
AU Narayan, S
Beck, MW
Reguero, BG
Losada, IJ
van Wesenbeeck, B
Pontee, N
Sanchirico, JN
Ingram, JC
Lange, GM
Burks-Copes, KA
AF Narayan, Siddharth
Beck, Michael W.
Reguero, Borja G.
Losada, Inigo J.
van Wesenbeeck, Bregje
Pontee, Nigel
Sanchirico, James N.
Ingram, Jane Carter
Lange, Glenn-Marie
Burks-Copes, Kelly A.
TI The Effectiveness, Costs and Coastal Protection Benefits of Natural and
Nature-Based Defences
SO PLOS ONE
LA English
DT Article
ID SEA-LEVEL RISE; CLIMATE-CHANGE; MANGROVE FOREST; SALT MARSHES;
VEGETATION; REDUCTION; SERVICES; VARIABILITY; ADAPTATION; ECOSYSTEMS
AB There is great interest in the restoration and conservation of coastal habitats for protection from flooding and erosion. This is evidenced by the growing number of analyses and reviews of the effectiveness of habitats as natural defences and increasing funding worldwide for nature-based defences-i.e. restoration projects aimed at coastal protection; yet, there is no synthetic information on what kinds of projects are effective and cost effective for this purpose. This paper addresses two issues critical for designing restoration projects for coastal protection: (i) a synthesis of the costs and benefits of projects designed for coastal protection (nature-based defences) and (ii) analyses of the effectiveness of coastal habitats (natural defences) in reducing wave heights and the biophysical parameters that influence this effectiveness. We (i) analyse data from sixty-nine field measurements in coastal habitats globally and examine measures of effectiveness of mangroves, salt-marshes, coral reefs and seagrass/kelp beds for wave height reduction; (ii) synthesise the costs and coastal protection benefits of fifty-two nature-based defence projects and; (iii) estimate the benefits of each restoration project by combining information on restoration costs with data from nearby field measurements. The analyses of field measurements show that coastal habitats have significant potential for reducing wave heights that varies by habitat and site. In general, coral reefs and salt-marshes have the highest overall potential. Habitat effectiveness is influenced by: a) the ratios of wave height-to-water depth and habitat width-to-wavelength in coral reefs; and b) the ratio of vegetation height-to-water depth in salt-marshes. The comparison of costs of nature-based defence projects and engineering structures show that salt-marshes and mangroves can be two to five times cheaper than a submerged breakwater for wave heights up to half a metre and, within their limits, become more cost effective at greater depths. Nature-based defence projects also report benefits ranging from reductions in storm damage to reductions in coastal structure costs.
C1 [Narayan, Siddharth] Univ Calif Santa Barbara, NCEAS, Santa Barbara, CA 93106 USA.
[Beck, Michael W.] Univ Calif Santa Cruz, Nat Conservancy, Santa Cruz, CA 95064 USA.
[Reguero, Borja G.] UC Santa Cruz, Nat Conservancy, Dept Ocean Sci, Santa Cruz, CA USA.
[Losada, Inigo J.] Univ Cantabria, ETSI Caminos Canales & Puertos, Inst Hidraul Ambiental, E-39005 Santander, Spain.
[van Wesenbeeck, Bregje] Delft Univ Technol, Deltares, Unit Marine & Coastal Syst, Delft, Netherlands.
[Pontee, Nigel] Univ Southampton, HILL CH2M, Coastal Planning & Engn, Swindon, Wilts, England.
[Sanchirico, James N.] Univ Calif Davis, Dept Environm Sci & Policy, Davis, CA 95616 USA.
[Ingram, Jane Carter] Columbia Univ, Wildlife Conservat Soc, New York, NY USA.
[Lange, Glenn-Marie] World Bank, Environm & Nat Resources Global Practice, 1818 H St NW, Washington, DC 20433 USA.
[Burks-Copes, Kelly A.] US Army, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS USA.
RP Narayan, S (reprint author), Univ Calif Santa Barbara, NCEAS, Santa Barbara, CA 93106 USA.
EM sid.narayan@gmail.com
FU Nature Conservancy; Wildlife Conservation Society; National Center for
Ecological Analysis and Synthesis (NCEAS); Lyda Hill Foundation; Pew
Fellowship in Marine Conservation; World Bank WAVES program
FX This research was primarily supported by the by SNAP: Science for Nature
and People, a collaboration of The Nature Conservancy, the Wildlife
Conservation Society and the National Center for Ecological Analysis and
Synthesis (NCEAS). The assistance and support of Dr. Filippo Ferrario,
Laval University, Quebec, is also gratefully acknowledged. We also
gratefully acknowledge support from the Lyda Hill Foundation, a Pew
Fellowship in Marine Conservation to MWB, and the World Bank WAVES
program.
NR 64
TC 1
Z9 1
U1 26
U2 51
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 2
PY 2016
VL 11
IS 5
AR e0154735
DI 10.1371/journal.pone.0154735
PG 17
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DL5KB
UT WOS:000375674800044
PM 27135247
ER
PT J
AU Tritsch, A
Airel, P
Schwake, J
Gancayco, J
AF Tritsch, Adam
Airel, Peter
Schwake, Jonothan
Gancayco, John
TI Does Topical Lidocaine Reduce The Amount of Intravenous Conscious
Sedation Required To Complete Diagnostic Upper Endoscopy and Shorten
Recovery Time? A Double Blinded, Randomized, Placebo Controlled Study
SO GASTROINTESTINAL ENDOSCOPY
LA English
DT Meeting Abstract
C1 [Tritsch, Adam; Airel, Peter; Schwake, Jonothan; Gancayco, John] Brooke Army Med Ctr, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0016-5107
EI 1097-6779
J9 GASTROINTEST ENDOSC
JI Gastrointest. Endosc.
PD MAY
PY 2016
VL 83
IS 5
SU S
MA Mo1004
BP AB422
EP AB423
PG 2
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA EI5HF
UT WOS:000392524200221
ER
PT J
AU Hack, DC
AF Hack, Dallas C.
TI Military Medicine: The Future and Beyond
SO MILITARY MEDICINE
LA English
DT Editorial Material
C1 [Hack, Dallas C.] US Army, Med Res & Mat Command, Res & Technol Headquarters, 810 Schreider St, Frederick, MD 21702 USA.
RP Hack, DC (reprint author), US Army, Med Res & Mat Command, Res & Technol Headquarters, 810 Schreider St, Frederick, MD 21702 USA.
NR 0
TC 0
Z9 0
U1 2
U2 2
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAY
PY 2016
VL 181
IS 5
SU S
BP 1
EP 1
DI 10.7205/MILMED-D-15-00519
PG 1
WC Medicine, General & Internal
SC General & Internal Medicine
GA DW5LJ
UT WOS:000383686400001
PM 27168544
ER
PT J
AU Doll, BA
AF Doll, Bruce A.
TI Pushing Boundaries
SO MILITARY MEDICINE
LA English
DT Editorial Material
C1 [Doll, Bruce A.] US Army, Med Res & Mat Command, 810 Schreider St, Frederick, MD 21702 USA.
RP Doll, BA (reprint author), US Army, Med Res & Mat Command, 810 Schreider St, Frederick, MD 21702 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAY
PY 2016
VL 181
IS 5
SU S
BP 2
EP 4
DI 10.7205/MILMED-D-15-00520
PG 3
WC Medicine, General & Internal
SC General & Internal Medicine
GA DW5LJ
UT WOS:000383686400002
PM 27168545
ER
PT J
AU Hatzfeld, JJ
Khalili, RA
Hendrickson, TL
Reilly, PA
AF Hatzfeld, Jennifer J.
Khalili, Ramin A.
Hendrickson, Teresa L.
Reilly, Patricia A.
TI Publishing Military Medical Research: Appreciating the Process
SO MILITARY MEDICINE
LA English
DT Editorial Material
C1 [Hatzfeld, Jennifer J.; Khalili, Ramin A.; Hendrickson, Teresa L.] Combat Casualty Care Res Program, Joint Program Comm 6, 722 Doughten St, Frederick, MD 21702 USA.
[Reilly, Patricia A.] US Army, Med Res & Mat Command, Off Principal Assistant Acquisit, 810 Schreider St, Frederick, MD 21702 USA.
RP Hatzfeld, JJ (reprint author), Combat Casualty Care Res Program, Joint Program Comm 6, 722 Doughten St, Frederick, MD 21702 USA.
NR 2
TC 0
Z9 0
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAY
PY 2016
VL 181
IS 5
SU S
BP 5
EP 6
DI 10.7205/MILMED-D-15-00517
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA DW5LJ
UT WOS:000383686400003
PM 27168546
ER
PT J
AU Larres, DT
Carr, W
Gonzales, EG
Hawley, JS
AF Larres, David T.
Carr, Walter
Gonzales, Elizandro G.
Hawley, Jason S.
TI The Natural History of Acute Recovery of Blast-Induced Mild Traumatic
Brain Injury: A Case Series During War
SO MILITARY MEDICINE
LA English
DT Article; Proceedings Paper
CT Military Health System Research Symposium
CY AUG 17-21, 2014
CL Fort Lauderdale, FL
ID ACUTE CONCUSSION; EXPLOSIVE BLAST; TBI; NEUROTRAUMA; MANAGEMENT;
EXPOSURE; UTILITY; MATTER; MODEL
AB Traumatic brain injury (TBI) secondary to blast exposure is a common injury in the Global War on Terrorism, but little is known about the acute effects, recovery, pathophysiology, and neuropathology of blast-induced mild TBI (mTBI) in humans in a battlefield environment. Moreover, there is ongoing debate whether blast-induced mTBI is a different injury with a unique pathophysiology compared with mTBI from blunt trauma. In the case series reported here from Craig Joint Theater Hospital at Bagram Airfield, Afghanistan, 15 military service members with acute concussion/mTBI associated with blast exposure were evaluated within the first 24 hours after concussion and on days 2, 3, 5, and 7 with a Graded Symptom Checklist and a balance assessment, the Balance Error Scoring System. These data suggest that the recovery in blast-induced mTBI follows the pattern of recovery in sports-related concussion reported in The National Collegiate Athletic Association Concussion Study. In this retrospective case series, we provide the first description of the natural history of acute recovery in blast-induced mTBI, and we suspect, given our experience treating military service members, that further observations of the natural history of recovery in blast-induced mTBI will continue to mirror the natural history of recovery in sports concussion.
C1 [Larres, David T.] Tripler Army Med Ctr, Occupat Therapy Clin, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
[Carr, Walter] Walter Reed Army Inst Res, Dept Behav Biol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
[Gonzales, Elizandro G.] Guthrie Army Hlth Clin, Occupat Therapy, 11050 Mt Belvedere Blvd, Ft Drum, NY 13602 USA.
[Hawley, Jason S.] Walter Reed Natl Mil Med Ctr, Dept Neurol, 8901 Rockville Pike, Bethesda, MD 20889 USA.
RP Larres, DT (reprint author), Tripler Army Med Ctr, Occupat Therapy Clin, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
NR 36
TC 0
Z9 0
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAY
PY 2016
VL 181
IS 5
SU S
BP 23
EP 27
DI 10.7205/MILMED-D-15-00152
PG 5
WC Medicine, General & Internal
SC General & Internal Medicine
GA DW5LJ
UT WOS:000383686400006
PM 27168549
ER
PT J
AU Carr, W
Stone, JR
Walilko, T
Young, LA
Snook, TL
Paggi, ME
Tsao, JW
Jankosky, CJ
Parish, RV
Ahlers, ST
AF Carr, Walter
Stone, James R.
Walilko, Tim
Young, Lee Ann
Snook, Tianlu Li
Paggi, Michelle E.
Tsao, Jack W.
Jankosky, Christopher J.
Parish, Robert V.
Ahlers, Stephen T.
TI Repeated Low-Level Blast Exposure: A Descriptive Human Subjects Study
SO MILITARY MEDICINE
LA English
DT Article; Proceedings Paper
CT Military Health System Research Symposium
CY AUG 17-21, 2014
CL Fort Lauderdale, FL
ID TRAUMATIC BRAIN-INJURY; NEUROPSYCHOLOGICAL ASSESSMENT METRICS;
FUNCTIONAL MRI; MILD; PERFORMANCE; CONCUSSION; SAMPLE
AB The relationship between repeated exposure to blast overpressure and neurological function was examined in the context of breacher training at the U.S. Marine Corps Weapons Training Battalion Dynamic Entry School. During this training, Students are taught to apply explosive charges to achieve rapid ingress into secured buildings. For this study, both Students and Instructors participated in neurobehavioral testing, blood toxin screening, vestibular/auditory testing, and neuroimaging. Volunteers wore instrumentation during training to allow correlation of human response measurements and blast overpressure exposure. The key findings of this study were from high-memory demand tasks and were limited to the Instructors. Specific tests showing blast-related mean differences were California Verbal Learning Test II, Automated Neuropsychological Assessment Metrics subtests (Match-to-Sample, Code Substitution Delayed), and Delayed Matching-to-Sample 10-second delay condition. Importantly, apparent deficits were paralleled with functional magnetic resonance imaging using the n-back task. The findings of this study are suggestive, but not conclusive, owing to small sample size and effect. The observed changes yield descriptive evidence for potential neurological alterations in the subset of individuals with occupational history of repetitive blast exposure. This is the first study to integrate subject instrumentation for measurement of individual blast pressure exposure, neurocognitive testing, and neuroimaging.
C1 [Carr, Walter] Walter Reed Army Inst Res, Dept Behav Biol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
[Stone, James R.; Snook, Tianlu Li] Univ Virginia Hlth Syst, 480 Ray C Hunt Dr,Room 281,Box 801339, Charlottesville, VA 22903 USA.
[Walilko, Tim] Appl Res Associates Inc, 7921 Shaffer Pkwy, Littleton, CO 80127 USA.
[Young, Lee Ann] Appl Res Associates Inc, 950 Isom Rd, San Antonio, TX 78216 USA.
[Paggi, Michelle E.] Weill Cornell Med Coll, 21 Bloomingdale Rd, White Plains, NY 10605 USA.
[Tsao, Jack W.] US Navy, Bur Med & Surg, Traumat Brain Injury Programs, 2300 East St Northwest, Washington, DC 20372 USA.
[Jankosky, Christopher J.] Uniformed Serv Univ Hlth Sci, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
[Parish, Robert V.] MEDCOM Irwin Army Community Hosp, 600 Caisson Hill Rd, Ft Riley, KS 66442 USA.
[Ahlers, Stephen T.] US Navy, Med Res Ctr, Operat & Undersea Med, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
RP Carr, W (reprint author), Walter Reed Army Inst Res, Dept Behav Biol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
NR 20
TC 1
Z9 1
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAY
PY 2016
VL 181
IS 5
SU S
BP 28
EP 39
DI 10.7205/MILMED-D-15-00137
PG 12
WC Medicine, General & Internal
SC General & Internal Medicine
GA DW5LJ
UT WOS:000383686400007
PM 27168550
ER
PT J
AU Martini, WZ
Rodriguez, CM
Deguzman, R
Guerra, JB
Martin, AK
Pusateri, AE
Cap, AP
Dubick, MA
AF Martini, Wenjun Z.
Rodriguez, Cassandra M.
Deguzman, Rodolfo
Guerra, Jessica B.
Martin, Angela K.
Pusateri, Anthony E.
Cap, Andrew P.
Dubick, Michael A.
TI Dose Responses of Ibuprofen In Vitro on Platelet Aggregation and
Coagulation in Human and Pig Blood Samples
SO MILITARY MEDICINE
LA English
DT Article; Proceedings Paper
CT Military Health System Research Symposium
CY AUG 17-21, 2014
CL Fort Lauderdale, FL
ID LACTATED RINGERS; OVERDOSE; PLASMA; HEMORRHAGE; MODEL; RESUSCITATION;
INHIBITION; SURVIVAL; EFFICACY; INJURY
AB Introduction: Ibuprofen is commonly used by warfighters in the deployed environment. This study investigated its dose effects on in vitro coagulation in human and pig blood. Methods: Blood samples were collected from 6 normal volunteers and 6 healthy pigs and processed to make platelet-adjusted samples (100 x 10(3)/mu L, common transfusion trigger in trauma). Ibuprofen was added to the samples at concentrations of 0 mu g/mL (control), the concentration from the highest recommended oral dose (163 mu g/mL, 1x), and 2x, 4x, 8x, 10x, 12x, 16x, and 20x. Platelet aggregation by Chrono-Log aggregometer and coagulation by rotational thrombelastogram (Rotem) were assessed at 15 minutes after the addition of ibuprofen. Results: A robust inhibition of ibuprofen on arachidonic acid-induced platelet aggregation was observed at all doses tested in human or pig blood. Collagen-stimulated platelet aggregation was inhibited starting at 1x in human blood and 4x in pig blood. Rotem measurements were similarly compromised in pig and human blood starting at 16x, except clot formation time was prolonged at 1x in human blood (all p < 0.05). Conclusion: Ibuprofen inhibited platelet aggregation at recommended doses, and compromised coagulation at higher doses. Human blood was more sensitive to ibuprofen inhibition. Further effort is needed to investigate ibuprofen dose responses on coagulation in vivo.
C1 [Martini, Wenjun Z.; Rodriguez, Cassandra M.; Deguzman, Rodolfo; Guerra, Jessica B.; Cap, Andrew P.; Dubick, Michael A.] US Army Inst Surg Res, 3698 Chambers Pass, San Antonio, TX 78234 USA.
[Martin, Angela K.] Rice Univ, 6100 Main St, Houston, TX 77005 USA.
[Pusateri, Anthony E.] US Army Med Res & Mat Command, 810 Schreider St 100, Frederick, MD 21702 USA.
RP Martini, WZ (reprint author), US Army Inst Surg Res, 3698 Chambers Pass, San Antonio, TX 78234 USA.
NR 29
TC 0
Z9 0
U1 2
U2 2
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAY
PY 2016
VL 181
IS 5
SU S
BP 111
EP 116
DI 10.7205/MILMED-D-15-00381
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA DW5LJ
UT WOS:000383686400017
PM 27168560
ER
PT J
AU Barnard, E
Mora, AG
Bebarta, VS
AF Barnard, Ed
Mora, Alejandra G.
Bebarta, Vikhyat S.
TI Preflight Variables Are Associated With Increased Ventilator Days and
30-Day Mortality in Trauma Casualties Evacuated by Critical Care Air
Transport Teams: An Exploratory Retrospective Study
SO MILITARY MEDICINE
LA English
DT Article; Proceedings Paper
CT Military Health System Research Symposium
CY AUG 17-21, 2014
CL Fort Lauderdale, FL
ID BRAIN-INJURY; SYSTEM; AFGHANISTAN; OPERATIONS; DEATH; IRAQ
AB Background: There are no tools to predict outcomes in the U.S. Air Force Critical Care Air Transport Team (CCATT) trauma patients. The objective of this study was to identify associations between preflight variables and outcomes that could assist planning of ongoing critical care. Methods: This Institutional Review Board approved retrospective study included all patients evacuated from Afghanistan by CCATT between 2007 and 2011. Preflight variables were assessed for associations and examined in logistic regression models. Ventilator time over 72 hours, and 30-day mortality were the primary and secondary outcomes respectively. Results: 1,308 trauma patients (24 years, 98% male) were included; 72% blast. Injury severity score (odds ratio [OR] = 1.04 [1.03-1.06]), preflight packed red blood cell units transfused (OR = 1.05 [1.04-1.07]), and preflight intubated status (OR = 11.9 [8.53-16.89]) were independently associated with increased ventilator days; a composite produced an area under the curve of 0.85 with 86% sensitivity and 56% specificity. Injury severity score (OR = 1.06 [1.03-1.09]), prothrombin time (OR = 2.13 [1.18-4.47]), preflight intubated status (OR = 9.2 [1.88-166.11]), and whole blood (OR = 3.18 [1.38-7.04]) were associated with 30-day mortality; a composite produced an area under the curve of 0.84 with 71% sensitivity and 57% specificity. Conclusion: In our large CCATT study a number of preflight variables were associated with outcomes, which may assist in the future planning of critical care services.
C1 [Barnard, Ed; Mora, Alejandra G.; Bebarta, Vikhyat S.] US Army Inst Surg Res, Air Force En Route Care Res Ctr, 59th Med Wing,3698 Chambers Pass Rd,Bldg 3611, San Antonio, TX 78234 USA.
[Barnard, Ed] Inst Naval Med, Crescent Rd, Alverstoke P012 2DL, Hants, England.
RP Barnard, E (reprint author), US Army Inst Surg Res, Air Force En Route Care Res Ctr, 59th Med Wing,3698 Chambers Pass Rd,Bldg 3611, San Antonio, TX 78234 USA.; Barnard, E (reprint author), Inst Naval Med, Crescent Rd, Alverstoke P012 2DL, Hants, England.
RI bebarta, vikhyat/K-3476-2015
NR 28
TC 0
Z9 0
U1 2
U2 2
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAY
PY 2016
VL 181
IS 5
SU S
BP 132
EP 137
DI 10.7205/MILMED-D-15-00134
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA DW5LJ
UT WOS:000383686400020
PM 27168563
ER
PT J
AU Mora, AG
Ganem, VJ
Ervin, AT
Maddry, JK
Bebarta, VS
AF Mora, Alejandra G.
Ganem, Victoria J.
Ervin, Alicia T.
Maddry, Joseph K.
Bebarta, Vikhyat S.
TI En Route Use of Analgesics in Nonintubated, Critically Ill Patients
Transported by US Air Force Critical Care Air Transport Teams
SO MILITARY MEDICINE
LA English
DT Article; Proceedings Paper
CT Military Health System Research Symposium
CY AUG 17-21, 2014
CL Fort Lauderdale, FL
ID POSTTRAUMATIC-STRESS-DISORDER; AEROMEDICAL EVACUATION; SERVICE MEMBERS;
PAIN; KETAMINE; IRAQ; OPERATIONS; MORPHINE; OUTCOMES; INJURY
AB Introduction: U.S. Critical Care Air Transport Teams (CCATTs) evacuate critically ill patients with acute pain in the combat setting. Limited data have been reported on analgesic administration en route, and no study has reported analgesic use by CCATTs. Our objective was to describe analgesics used by CCATTs for nonintubated, critically ill patients during evacuation from a combat setting. Methods: We conducted an institutional review board-approved, retrospective review of CCATT records. We included nonintubated, critically ill patients who were administered analgesics in flight and were evacuated out of theater (2007-2012). Demographics, injury description, analgesics and anesthetics, and predefined clinical adverse events were recorded. Data were presented as mean +/- standard deviation or percentage (%). Results: Of 1,128 records, we analyzed 381 subjects with the following characteristics: age 26 +/- 7.0 years; 98% male; and 97% trauma (70% blast, 17% penetrating, 11% blunt, and 3% burn). The injury severity score was 19 +/- 9. Fifty-one percent received morphine, 39% hydromorphone, 15% fentanyl, and 5% ketamine. Routes of delivery were 63% patient-controlled analgesia (PCA), 32% bolus intravenous (IV) administration, 24% epidural delivery, 21% continuous IV infusions, and 9% oral opioids. Patients that were administered local anesthetics (nerve block or epidural delivery) with IV opioids received a lower total dose of opioids than those who received opioids alone. No differences were associated between analgesics and frequency of complications in flight or postflight. Conclusion: About half of nonintubated, critically ill subjects evacuated out of combat by CCATT received morphine and more than half had a PCA. In our study, ketamine was not frequently used and pain scores were rarely recorded. However, we detected an opioid-sparing effect associated with local anesthetics (regional nerve blocks and epidural delivery).
C1 [Mora, Alejandra G.; Ganem, Victoria J.; Ervin, Alicia T.; Maddry, Joseph K.; Bebarta, Vikhyat S.] US Army, Air Force Route Care Res Ctr, Inst Surg Res, 59th MDW,3698 Chambers Pass Rd,Bldg 3611, Ft Sam Houston, TX 78234 USA.
[Maddry, Joseph K.; Bebarta, Vikhyat S.] San Antonio Mil Med Ctr, Dept Emergency Med, Brooke Army Med Ctr, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
RP Mora, AG (reprint author), US Army, Air Force Route Care Res Ctr, Inst Surg Res, 59th MDW,3698 Chambers Pass Rd,Bldg 3611, Ft Sam Houston, TX 78234 USA.
RI bebarta, vikhyat/K-3476-2015
NR 23
TC 0
Z9 0
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAY
PY 2016
VL 181
IS 5
SU S
BP 145
EP 151
DI 10.7205/MILMED-D-15-00194
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA DW5LJ
UT WOS:000383686400022
PM 27168565
ER
PT J
AU Nemeth, C
Anders, S
Strouse, R
Grome, A
Crandall, B
Pamplin, J
Salinas, J
Mann-Salinas, E
AF Nemeth, Christopher
Anders, Shilo
Strouse, Robert
Grome, Anna
Crandall, Beth
Pamplin, Jeremy
Salinas, Jose
Mann-Salinas, Elizabeth
TI Developing a Cognitive and Communications Tool for Burn Intensive Care
Unit Clinicians
SO MILITARY MEDICINE
LA English
DT Article; Proceedings Paper
CT Military Health System Research Symposium
CY AUG 17-21, 2014
CL Fort Lauderdale, FL
AB Background: Burn Intensive Care Unit (BICU) work is necessarily complex and depends on clinician actions, resources, and variable patient responses to interventions. Clinicians use large volumes of data that are condensed in time, but separated across resources, to care for patients. Correctly designed health information technology ( IT) systems may help clinicians to treat these patients more efficiently, accurately, and reliably. We report on a 3-year project to design and develop an ecologically valid IT system for use in a military BICU. Methods: We use a mixed methods Cognitive Systems Engineering approach for research and development. Observations, interviews, artifact analysis, survey, and thematic analysis methods were used to reveal underlying factors that mold the work environment and affect clinician decisions that may affect patient outcomes. Participatory design and prototyping methods have been used to develop solutions. Results: We developed 39 requirements for the IT system and used them to create three use cases to help developers better understand how the system might support clinician work to develop interface prototypes. We also incorporated data mining functions that offer the potential to aid clinicians by recognizing patterns recognition of clinically significant events, such as incipient sepsis. The gaps between information sources and accurate, reliable, and efficient clinical decision that we have identified will enable us to create scenarios to evaluate prototype systems with BICU clinicians, to develop increasingly improved designs, and to measure outcomes. Conclusion: The link from data to analyses, requirements, prototypes, and their evaluation ensures that the solution will reflect and support work in the BICU as it actually occurs, improving staff efficiency and patient care quality.
C1 [Nemeth, Christopher; Anders, Shilo; Strouse, Robert; Grome, Anna; Crandall, Beth] Appl Res Associates Inc, Cognit Solut Div, 1750 Commerce Ctr Blvd Dr North, Fairborn, OH 23542 USA.
[Pamplin, Jeremy; Salinas, Jose; Mann-Salinas, Elizabeth] US Army Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.
RP Nemeth, C (reprint author), Appl Res Associates Inc, Cognit Solut Div, 1750 Commerce Ctr Blvd Dr North, Fairborn, OH 23542 USA.
NR 18
TC 0
Z9 0
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAY
PY 2016
VL 181
IS 5
SU S
BP 205
EP 213
DI 10.7205/MILMED-D-15-00173
PG 9
WC Medicine, General & Internal
SC General & Internal Medicine
GA DW5LJ
UT WOS:000383686400031
PM 27168574
ER
PT J
AU Drignei, D
Mourelatos, Z
Kosova, E
Hu, J
Reed, M
Rupp, J
Gruber, R
Scherer, R
AF Drignei, Dorin
Mourelatos, Zissimos
Kosova, Ervisa
Hu, Jingwen
Reed, Matthew
Rupp, Jonathan
Gruber, Rebekah
Scherer, Risa
TI Uncertainty Assessment in Restraint System Optimization for Occupants of
Tactical Vehicles
SO SAE INTERNATIONAL JOURNAL OF MATERIALS AND MANUFACTURING
LA English
DT Article
AB We have recently obtained experimental data and used them to develop computational models to quantify occupant impact responses and injury risks for military vehicles during frontal crashes. The number of experimental tests and model runs are however, relatively small due to their high cost. While this is true across the auto industry, it is particularly critical for the Army and other government agencies operating under tight budget constraints. In this study we investigate through statistical simulations how the injury risk varies if a large number of experimental tests were conducted. We show that the injury risk distribution is skewed to the right implying that, although most physical tests result in a small injury risk, there are occasional physical tests for which the injury risk is extremely large. We compute the probabilities of such events and use them to identify optimum design conditions to minimize such probabilities. We also show that the results are robust to various assumptions that the statistical simulations use.
C1 [Drignei, Dorin; Mourelatos, Zissimos; Kosova, Ervisa] Oakland Univ, Rochester, MI 48063 USA.
[Hu, Jingwen; Reed, Matthew] Univ Michigan, Ann Arbor, MI 48109 USA.
[Rupp, Jonathan] Transportat Res Inst, Ann Arbor, MI USA.
[Gruber, Rebekah] US Army, TARDEC, Warren, MI USA.
[Scherer, Risa] US Army, Washington, DC 20310 USA.
RP Drignei, D (reprint author), Oakland Univ, Dept Math & Stat, Rochester, MI 48063 USA.; Mourelatos, Z (reprint author), Oakland Univ, Dept Mech Engn, Rochester, MI 48063 USA.
EM drignei@oakland.edu; mourelat@oakland.edu
NR 10
TC 0
Z9 0
U1 0
U2 0
PU SAE INT
PI WARRENDALE
PA 400 COMMONWEALTH DR, WARRENDALE, PA 15096 USA
SN 1946-3979
EI 1946-3987
J9 SAE INT J MATER MANU
JI SAE Int. J. Mater. Manuf.
PD MAY
PY 2016
VL 9
IS 2
BP 436
EP 443
DI 10.4271/2016-01-0316
PG 8
WC Transportation Science & Technology
SC Transportation
GA EA2TS
UT WOS:000386448300027
ER
PT J
AU Petty, AA
Hutchings, JK
Richter-Menge, JA
Tschudi, MA
AF Petty, Alek A.
Hutchings, Jennifer K.
Richter-Menge, Jacqueline A.
Tschudi, Mark A.
TI Sea ice circulation around the Beaufort Gyre: The changing role of wind
forcing and the sea ice state
SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS
LA English
DT Article
ID ARCTIC-OCEAN; ERA-INTERIM; SNOW DEPTH; MODEL; IMPACT; DRAG; SIMULATIONS;
VARIABILITY; CURRENTS; MOTION
AB Sea ice drift estimates from feature tracking of satellite passive microwave data are used to investigate seasonal trends and variability in the ice circulation around the Beaufort Gyre, over the multidecadal period 1980-2013. Our results suggest an amplified response of the Beaufort Gyre ice circulation to wind forcing, especially during the late 2000s. We find increasing anticyclonic ice drift across all seasons, with the strongest trend in autumn, associated with increased ice export out of the southern Beaufort Sea (into the Chukchi Sea). A flux gate analysis highlights consistency across a suite of drift products. Despite these seasonal anticyclonic ice drift trends, a significant anticyclonic wind trend occurs in summer only, driven, in-part, by anomalously anticyclonic winds in 2007. Across all seasons, the ice drift curl is more anticyclonic than predicted from a linear relationship to the wind curl in the 2000s, compared to the 1980s/1990s. The strength of this anticyclonic ice drift curl amplification is strongest in autumn and appears to have increased since the 1980s (up to 2010). In spring and summer, the ice drift curl amplification occurs mainly between 2007 and 2010. These results suggest nonlinear ice interaction feedbacks (e.g., a weaker, more mobile sea ice pack), enhanced atmospheric drag, and/or an increased role of the ocean. The results also show a weakening of the anticyclonic wind and ice circulation since 2010.
C1 [Petty, Alek A.] Univ Maryland, Earth Syst Sci Interdisciplinary Ctr, College Pk, MD 20742 USA.
[Petty, Alek A.] NASA, Goddard Space Flight Ctr, Cryospher Sci Lab, Greenbelt, MD 20771 USA.
[Hutchings, Jennifer K.] Oregon State Univ, Coll Earth Ocean & Atmosphere, Corvallis, OR 97331 USA.
[Richter-Menge, Jacqueline A.] Cold Reg Res & Engn Lab, Hanover, NH USA.
[Tschudi, Mark A.] Univ Colorado, Colorado Ctr Astrodynam Res, Boulder, CO 80309 USA.
RP Petty, AA (reprint author), Univ Maryland, Earth Syst Sci Interdisciplinary Ctr, College Pk, MD 20742 USA.; Petty, AA (reprint author), NASA, Goddard Space Flight Ctr, Cryospher Sci Lab, Greenbelt, MD 20771 USA.
EM alek.a.petty@nasa.gov
FU NASA [NNX13AK36G]; NOAA Ocean Remote Sensing Program
FX This work is supported by NASA grant NNX13AK36G and the NOAA Ocean
Remote Sensing Program. The NCEP-R2 data were provided by the NOAA/ESRL
PSD
(http://www.esrl.noaa.gov/psd/data/gridded/data.ncep.reanalysis2.html),
the ERA-I data were provided by the ECMWF
(http://apps.ecmwf.int/datasets/data/interim_full_daily/), and the
JRA-55 data were provided by the NCEP Research Data Archive (RDA)
(http://rda.ucar.edu/datasets/ds628.0). The Polar Pathfinder sea ice
drift data were provided by the NSIDC
(http://nsidc.org/data/nsidc-0116). All CERSAT/IFREMER data sets were
obtained from the CERSAT website
(ftp://ftp.ifremer.fr/ifremer/cersat/products/gridded/psi-drift/). The
passive microwave NASA Team and Bootstrap concentration data were
provided by the NSIDC (http://nsidc.org/data/nsidc-0051 and
http://nsidc.org/data/nsidc-0079, respectively). The ice draft mooring
data were obtained from the Beaufort Gyre Exploration Project website
(http://www.whoi.edu/page.do?pid=66559). PIOMAS ice thickness data were
obtained from
http://psc.apl.uw.edu/research/projects/arctic-sea-ice-volume-anomaly/da
ta/. We thank the Editor (Andrey Proshutinsky), three anonymous
reviewers, and Miles McPhee for instructive comments that greatly
strengthened this manuscript. We would also like to thank the organizers
and participants of the 2014 Forum for Arctic Ocean Modeling and
Observational Synthesis (FAMOS) workshop for the useful and inspiring
discussions regarding this work. We also thank Sinead Farrell for her
assistance with earlier versions of this manuscript. All processed
datasets used in this study have been archived at
http://dx.doi.org/10.5281/zenodo.48464, while the data processing
scripts used to create the data/figures are available at
https://www.github.com/akpetty/bgdrift2016.git. The primary author may
be contacted for any further data requests.
NR 74
TC 2
Z9 2
U1 5
U2 5
PU AMER GEOPHYSICAL UNION
PI WASHINGTON
PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA
SN 2169-9275
EI 2169-9291
J9 J GEOPHYS RES-OCEANS
JI J. Geophys. Res.-Oceans
PD MAY
PY 2016
VL 121
IS 5
BP 3278
EP 3296
DI 10.1002/2015JC010903
PG 19
WC Oceanography
SC Oceanography
GA DW2IQ
UT WOS:000383466500027
ER
PT J
AU Mullen, GL
Panario, D
Thomson, D
AF Mullen, G. L.
Panario, D.
Thomson, D.
TI Fast and Simple Modular Interpolation Using Factorial Representation
SO AMERICAN MATHEMATICAL MONTHLY
LA English
DT Article
ID POLYNOMIAL FUNCTIONS; Z(M); Z(N)
AB We study a representation for polynomial functions over finite rings. This factorial representation is particularly useful for fast interpolation, and we show that it is computationally preferable to the Lagrange Interpolation Formula (LIF) and to Newton interpolation over finite fields and rings. Moreover, over arbitrary finite rings the calculation of the factorial representation aborts naturally when a given mapping does not arise as a polynomial function.
C1 [Mullen, G. L.] Penn State Univ, Dept Math, University Pk, PA 16802 USA.
[Panario, D.] Carleton Univ, Sch Math & Stat, 1125 Colonel Dr, Ottawa, ON K1S 5B6, Canada.
[Thomson, D.] US Mil Acad, Army Cyber Inst, 2101 New South Post Rd,Spellman Hall, West Point, NY 10996 USA.
RP Mullen, GL (reprint author), Penn State Univ, Dept Math, University Pk, PA 16802 USA.
EM mullen@math.psu.edu; daniel@math.carleton.ca; David.Thomson@usma.edu
NR 11
TC 0
Z9 0
U1 0
U2 0
PU MATHEMATICAL ASSOC AMER
PI WASHINGTON
PA 1529 18TH STREET NW, WASHINGTON, DC 20036 USA
SN 0002-9890
EI 1930-0972
J9 AM MATH MON
JI Am. Math. Mon.
PD MAY
PY 2016
VL 123
IS 5
BP 471
EP 480
DI 10.4169/amer.math.monthly.123.5.471
PG 10
WC Mathematics
SC Mathematics
GA DT8PX
UT WOS:000381754700006
ER
PT J
AU Bazzill, JD
Cooper, CL
Fan, YC
Bavari, S
Moon, JJ
AF Bazzill, Joseph D.
Cooper, Christopher L.
Fan, Yuchen
Bavari, Sina
Moon, James J.
TI Lipid nanoparticles incorporated with Ebola glycoprotein for induction
of humoral immunity against Ebola infection.
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Association-of-Immunologists (AAI)
CY MAY 13-17, 2016
CL Seattle, WA
SP Amer Assoc Immunologists
C1 [Bazzill, Joseph D.; Fan, Yuchen; Moon, James J.] Univ Michigan, Ann Arbor, MI 48109 USA.
[Cooper, Christopher L.; Bavari, Sina] US Army Med Res Inst Infect Dis, Ft Detrick, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD MAY 1
PY 2016
VL 196
SU 1
PG 2
WC Immunology
SC Immunology
GA DS0LX
UT WOS:000380288302377
ER
PT J
AU Stonier, SW
James, RM
Josleyn, NM
Bakken, RR
Dye, JM
AF Stonier, Spencer W.
James, Rebekah M.
Josleyn, Nicole M.
Bakken, Russell R.
Dye, John M.
TI Immune correlates for VEEV replicon vaccine protection against
Ebolavirus
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Association-of-Immunologists (AAI)
CY MAY 13-17, 2016
CL Seattle, WA
SP Amer Assoc Immunologists
C1 [Stonier, Spencer W.; James, Rebekah M.; Josleyn, Nicole M.; Bakken, Russell R.; Dye, John M.] US Army Med Res Inst Infect Dis, Ft Detrick, MD USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD MAY 1
PY 2016
VL 196
SU 1
MA 146.8
PG 2
WC Immunology
SC Immunology
GA DS0LX
UT WOS:000380288301139
ER
PT J
AU Castellani, JW
Zambraski, EJ
Sawka, MN
Urso, ML
AF Castellani, John W.
Zambraski, Edward J.
Sawka, Michael N.
Urso, Maria L.
TI Does high muscle temperature accentuate skeletal muscle injury from
eccentric exercise?
SO PHYSIOLOGICAL REPORTS
LA English
DT Article
DE Cytokines; eccentric exercise; heat-shock proteins; interleukins;
maximal voluntary contraction
ID HEAT-SHOCK PROTEINS; INFLAMMATORY MEDIATORS; DAMAGE; HUMANS;
ACCLIMATION; ADAPTATION; METABOLISM; STRESS; INTERLEUKIN-6; PERFORMANCE
AB Hyperthermia is suspected of accentuating skeletal muscle injury from novel exercise, but this has not been well studied. This study examined if high muscle temperatures alters skeletal muscle injury induced by eccentric exercise (ECC). Eight volunteers (age, 22.5 +/- 4.1 year; height, 169.5 +/- 10.8 cm; body mass, 76.2 +/- 12.6 kg), serving as their own control, and who were not heat acclimatized, completed two elbow flexor ECC trials; in one trial the biceps were heated >40 degrees C (HEAT) and in the other trial there was no heating (NON). HEAT was applied with shortwave diathermy (100 W) for 15 min immediately before the first ECC bout and for 2 min in between each bout. Individuals were followed for 10 days after each ECC session, with a 6-week washout period between arms. The maximal voluntary isometric contraction decreased by 41 +/- 17% and 46 +/- 20% in the NON and HEAT trials, respectively. Bicep circumference increased by 0.07 +/- 0.08 mm (4%, P = 0.04) and relaxed range of motion decreased by 11.5 +/- 8.2 degrees (30%, P < 0.001) in both trials. Serum creatine kinase peaked 72-h following ECC (NON: 6289 +/- 10407; HEAT: 5486 +/- 6229 IU L-1, 38-fold increase, P < 0.01) as did serum myoglobin (NON: 362 +/- 483; HEAT: 355 +/- 373 mu g L-1, 13-fold increase, P < 0.03). Plasma HSP 70 was higher (P < 0.02) in HEAT after 120-h of recovery. There were no differences between treatments for plasma HSP27 and interleukins 1 beta, 6, and 10. The results indicate that >40 degrees C muscle temperature does not alter skeletal muscle injury or functional impairments induced by novel ECC.
C1 [Castellani, John W.; Zambraski, Edward J.; Sawka, Michael N.; Urso, Maria L.] US Army Res Inst Environm Med, Natick, MA USA.
RP Castellani, JW (reprint author), US Army Res Inst Environm Med, Thermal & Mt Med Div, 10 Gen Greene Ave,Bldg 42, Natick, MA 01760 USA.
EM john.w.castellani.civ@mail.mil
NR 40
TC 1
Z9 1
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2051-817X
J9 PHYSIOL REP
JI PHYSIOL. REP.
PD MAY
PY 2016
VL 4
IS 9
AR e12777
DI 10.14814/phy2.12777
PG 11
WC Physiology
SC Physiology
GA DR9VQ
UT WOS:000380244600002
ER
PT J
AU Jacobs, K
Wu, RB
Wang, XT
Ashhab, S
Chen, QM
Rabitz, H
AF Jacobs, Kurt
Wu, Rebing
Wang, Xiaoting
Ashhab, Sahel
Chen, Qi-Ming
Rabitz, Herschel
TI Fast quantum communication in linear networks
SO EPL
LA English
DT Article
ID EVOLUTION
AB Here we consider the speed at which quantum information can be transferred between the nodes of a linear network. Because such nodes are linear oscillators, this speed is also important in the cooling and state preparation of mechanical oscillators, as well as in frequency conversion. We show that if there is no restriction on the size of the linear coupling between two oscillators, then there exist control protocols that will swap their respective states with high fidelity within a time much shorter than a single oscillation period. Standard gradient search methods fail to find these fast protocols. We were able to do so by augmenting standard search methods with a path-tracing technique, demonstrating that this technique has remarkable power to solve time-optimal control problems, as well as confirming the highly challenging nature of these problems. As a further demonstration of the power of path tracing, first introduced by Moore Tibbets et al. (Phys. Rev. A, 86 (2012) 062309), we apply it to the generation of entanglement in a linear network. Copyright (C) EPLA, 2016
C1 [Jacobs, Kurt] US Army, Res Lab, Computat & Informat Sci Directorate, Adelphi, MD 20783 USA.
[Jacobs, Kurt] Univ Massachusetts, Dept Phys, Boston, MA 02125 USA.
[Jacobs, Kurt; Wang, Xiaoting] Louisiana State Univ, Hearne Inst Theoret Phys, Baton Rouge, LA 70803 USA.
[Wu, Rebing; Chen, Qi-Ming] Tsinghua Univ, Dept Automat, Beijing 100084, Peoples R China.
[Wu, Rebing; Chen, Qi-Ming] Ctr Quantum Informat Sci & Technol TNList, Beijing 100084, Peoples R China.
[Ashhab, Sahel] Hamad Bin Khalifa Univ, Qatar Environm & Energy Res Inst, Qatar Fdn, Doha, Qatar.
[Rabitz, Herschel] Princeton Univ, Dept Chem, Princeton, NJ 08544 USA.
RP Jacobs, K (reprint author), US Army, Res Lab, Computat & Informat Sci Directorate, Adelphi, MD 20783 USA.; Jacobs, K (reprint author), Univ Massachusetts, Dept Phys, Boston, MA 02125 USA.; Jacobs, K (reprint author), Louisiana State Univ, Hearne Inst Theoret Phys, Baton Rouge, LA 70803 USA.
RI Wu, Rebing/A-3647-2013
OI Wu, Rebing/0000-0003-3545-8700
FU NSF [PHY-1005571, PHY-1212413, CCF-1350397]; ARO MURI
[W911NF-11-1-0268,]; NSFC [60904034, 61374091, 61134008]
FX In the early part of this work KJ was partially supported by the NSF
Project Nos. PHY-1005571 and PHY-1212413. KJ and HR were partially
supported by the ARO MURI grant W911NF-11-1-0268, and RBW by the NSFC
Grant Nos. 60904034, 61374091, and 61134008. XW acknowledges support
from the NSF Project No. CCF-1350397.
NR 34
TC 0
Z9 0
U1 7
U2 7
PU EPL ASSOCIATION, EUROPEAN PHYSICAL SOCIETY
PI MULHOUSE
PA 6 RUE DES FRERES LUMIERE, MULHOUSE, 68200, FRANCE
SN 0295-5075
EI 1286-4854
J9 EPL-EUROPHYS LETT
JI EPL
PD MAY
PY 2016
VL 114
IS 4
AR 40007
DI 10.1209/0295-5075/114/40007
PG 6
WC Physics, Multidisciplinary
SC Physics
GA DQ9IR
UT WOS:000379524100007
ER
PT J
AU Malvasi, S
Gloyeske, B
Johnson, M
Miller, T
AF Malvasi, Steven
Gloyeske, Brian
Johnson, Matthew
Miller, Timothy
TI Multi-Ligamentous Knee Injury in Sports Involving Concomitant Anterior
Cruciate Ligament and Patellar Tendon Disruption: A Review of Case
Reports
SO INTERNATIONAL JOURNAL OF ATHLETIC THERAPY & TRAINING
LA English
DT Review
DE patellar tendon; anterior cruciate ligament; repair
ID SIMULTANEOUS RUPTURE
AB Background: Injury to the anterior cruciate ligament (ACL) is one of the most common orthopedic injuries in the United States, while injury to the patellar tendon (PT) is less common. A combined rupture to the ACL and PT is consequentially uncommon and increases the difficulty of a correct initial diagnosis. The purpose of this paper is to critically appraise the current peer-reviewed literature regarding multi-ligamentous knee injuries (MLKI) in sport. Methods: A systematic review was undertaken to identify all relevant peer-reviewed articles regarding MLKI from March 1980 to January 2015. All articles pertaining to simultaneous rupture of the ACL and PT were included for review. Results: A total of 27 cases presented in 15 articles were used. Findings suggest that the combination of a palpable gap over the PT, a positive Lachman test, inability to complete terminal knee extension, and a superior position of the patella are clinical examination markers for a possible MLKI involving the ACL and PT. Conclusion: Simultaneous rupture to the ACL and PT is incredibly rare within the sport population, making diagnosis and treatment of such injury challenging. A thorough examination of the extensor mechanism of the knee is important in making the proper diagnosis.
C1 [Malvasi, Steven] Keller Army Community Hosp, Dept Orthoped Surg, West Point, NY 10996 USA.
[Gloyeske, Brian] St Lukes Univ Hlth Network, Dept Sports Med, Bethlehem, PA USA.
[Johnson, Matthew; Miller, Timothy] St Lukes Univ Hlth Network, Dept Phys Therapy, Bethlehem, PA USA.
RP Malvasi, S (reprint author), Keller Army Community Hosp, Dept Orthoped Surg, West Point, NY 10996 USA.
NR 19
TC 0
Z9 0
U1 1
U2 1
PU HUMAN KINETICS PUBL INC
PI CHAMPAIGN
PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA
SN 2157-7277
EI 2157-7285
J9 INT J ATHL THER TRAI
JI Int. J. Athl. Ther. Train.
PD MAY
PY 2016
VL 21
IS 3
BP 24
EP 27
DI 10.1123/ijatt.2015-0049
PG 4
WC Sport Sciences
SC Sport Sciences
GA DQ5AC
UT WOS:000379215700005
ER
PT J
AU Drost, RJ
Moore, TJ
Brodsky, M
AF Drost, Robert J.
Moore, Terrence J.
Brodsky, Michael
TI Switching Networks for Pairwise-Entanglement Distribution
SO JOURNAL OF OPTICAL COMMUNICATIONS AND NETWORKING
LA English
DT Article
DE Optical fiber networks; Optical switching networks; Quantum
entanglement; Quantum networks
ID PHOTON-PAIRS; QUANTUM; FIBER
AB Quantum networks have the potential to enhance the utility of quantum protocols (for, e.g., cryptography, communication, computation, etc.) by enabling the interoperation of multiple quantum systems. In this paper, we address the distribution of entanglement to the neighbors of a central entanglement source node equipped with a number of sources of entangled photon pairs. A switching network can be an effective component connecting the central node to its neighbors, thus enabling the reconfigurable routing of generated photons. We consider optimal (in terms of insertion loss and the number of component switches) photonic switching networks designed to satisfy the particular requirements of entanglement distribution. We begin by developing a rigorous framework for the study of such entanglement-distribution switching networks. Next, we devise and apply search strategies to design optimal switching networks applicable to entanglement source nodes with 10 or fewer neighbors. Scalable switching networks are then considered for an arbitrarily large number of neighbors, resulting in asymptotically optimal switching fabrics. For all designs, we address efficient routing algorithms for determining a switching-network state that provides the entanglement distribution desired of the switching network at a given time. The combination of optimal switching-network structures and associated efficient routing algorithms addresses a key component of entanglement distribution, thus advancing the state of the art of quantum networks toward practical implementation.
C1 [Drost, Robert J.; Moore, Terrence J.; Brodsky, Michael] US Army Res Lab, Adelphi, MD 20783 USA.
RP Drost, RJ (reprint author), US Army Res Lab, Adelphi, MD 20783 USA.
EM robert.j.drost6.civ@mail.mil
NR 26
TC 1
Z9 1
U1 0
U2 0
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 1943-0620
EI 1943-0639
J9 J OPT COMMUN NETW
JI J. Opt. Commun. Netw.
PD MAY
PY 2016
VL 8
IS 5
BP 331
EP 342
DI 10.1364/JOCN.8.000331
PG 12
WC Computer Science, Hardware & Architecture; Computer Science, Information
Systems; Optics; Telecommunications
SC Computer Science; Optics; Telecommunications
GA DP5LQ
UT WOS:000378539200006
ER
PT J
AU Wallen, BM
Smits, KM
Sakaki, T
Howington, SE
Deepagoda, TKKC
AF Wallen, Benjamin M.
Smits, Kathleen M.
Sakaki, Toshihiro
Howington, Stacy E.
Deepagoda, Chamindu T. K. K.
TI Thermal Conductivity of Binary Sand Mixtures Evaluated through Full
Water Content Range
SO SOIL SCIENCE SOCIETY OF AMERICA JOURNAL
LA English
DT Article
ID DUAL-POROSITY MODEL; HEAT-PULSE METHOD; REDUCED AIR-PRESSURE; HYDRAULIC
CONDUCTIVITY; SEDIMENT MIXTURES; ERROR ANALYSIS; POROUS-MEDIA;
WIDE-RANGE; SOIL; TEMPERATURE
AB A soil's grain-size distribution affects its physical and hydraulic properties; however, little is known about its effect on soil thermal properties. To better understand how grain-size distribution affects soil thermal properties, specifically the effective thermal conductivity, a set of laboratory experiments was performed using binary mixtures of two uniform sands tightly packed with seven different mixing fractions over the full range of saturation. For each binary mixture, the effective thermal conductivity, lambda, capillary pressure, h(c), and volumetric water content, theta, were measured. Results demonstrated that the lambda-theta relationship exhibited distinct characteristics based on the percentage of fine-and coarse-grained sands. We further compared measured lambda-theta properties with independent estimates from two semi-empirical models (Campbell Model and Lu and Dong Model) to evaluate the models' applicability in relation to physically based parameters associated with changes in soil mixing (e.g., porosity and grain size). Both models were able to fit experimental data but to varying degrees based on the number of physically based parameters used. In general, model improvements are needed to capture the lambda-theta relationship solely on physically based parameters.
C1 [Wallen, Benjamin M.; Smits, Kathleen M.; Sakaki, Toshihiro] Colorado Sch Mines, Dept Civil & Environm Engn, Ctr Expt Study Subsurface Environm Proc CESEP, Golden, CO 80401 USA.
[Howington, Stacy E.] US Army, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Deepagoda, Chamindu T. K. K.] Univ Peradeniya, Dept Civil Engn, Peradeniya 20400, Sri Lanka.
RP Wallen, BM (reprint author), Colorado Sch Mines, Dept Civil & Environm Engn, Ctr Expt Study Subsurface Environm Proc CESEP, Golden, CO 80401 USA.
EM benwallen@earthlink.net
FU U. S. Army Research Office Award [W911NF-04-1-0169]; Engineering
Research and Development Center (ERDC); National Science Foundation
[CMMI-1230544, EAR-1447533]
FX This research was funded by the U. S. Army Research Office Award
W911NF-04-1-0169, the Engineering Research and Development Center
(ERDC), and the National Science Foundation (CMMI-1230544 and
EAR-1447533). The authors thank John Peters from ERDC for conversations
that improved this research and L. Scott Baggett and William J. Massman
from the USDA Forest Service whose careful review and comments
significantly improved the manuscript. For access to experimental data,
the reader is referred to Kathleen Smits (ksmits@mines.edu) at the
Colorado School of Mines.
NR 76
TC 0
Z9 0
U1 9
U2 10
PU SOIL SCI SOC AMER
PI MADISON
PA 677 SOUTH SEGOE ROAD, MADISON, WI 53711 USA
SN 0361-5995
EI 1435-0661
J9 SOIL SCI SOC AM J
JI Soil Sci. Soc. Am. J.
PD MAY-JUN
PY 2016
VL 80
IS 3
BP 592
EP 603
DI 10.2136/sssaj2015.11.0408
PG 12
WC Soil Science
SC Agriculture
GA DP9WP
UT WOS:000378848900006
ER
PT J
AU Moore, NLT
Altman, DE
Gauchan, S
Genovese, RF
AF Moore, Nicole L. T.
Altman, Daniel E.
Gauchan, Sangeeta
Genovese, Raymond F.
TI Adulthood stress responses in rats are variably altered as a factor of
adolescent stress exposure
SO STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
LA English
DT Article
DE Adolescence; adulthood; behavior; development; modulation; predator
exposure; stress; underwater trauma
ID DORSOLATERAL PERIAQUEDUCTAL GRAY; PREDATOR ODOR EXPOSURE;
POSTTRAUMATIC-STRESS; CALORIE RESTRICTION; GENE-EXPRESSION;
BEHAVIORAL-INHIBITION; DEFENSIVE BEHAVIORS; CHILDHOOD ADVERSITY; LIVE
PREDATOR; FEMALE RATS
AB Stress exposure during development may influence adulthood stress response severity. The present study investigates persisting effects of two adolescent stressors upon adulthood response to predator exposure (PE). Rats were exposed to underwater trauma (UWT) or PE during adolescence, then to PE after reaching adulthood. Rats were then exposed to predator odor (PO) to test responses to predator cues alone. Behavioral and neuroendocrine assessments were conducted to determine acute effects of each stress experience. Adolescent stress altered behavioral response to adulthood PE. Acoustic startle response was blunted. Bidirectional changes in plus maze exploration were revealed as a factor of adolescent stress type. Neuroendocrine response magnitude did not predict severity of adolescent or adult stress response, suggesting that different adolescent stress events may differentially alter developmental outcomes regardless of acute behavioral or neuroendocrine response. We report that exposure to two different stressors in adolescence may differentially affect stress response outcomes in adulthood. Acute response to an adolescent stressor may not be consistent across all stressors or all dependent measures, and may not predict alterations in developmental outcomes pertaining to adulthood stress exposure. Further studies are needed to characterize factors underlying long-term effects of a developmental stressor.
C1 [Moore, Nicole L. T.; Altman, Daniel E.; Gauchan, Sangeeta; Genovese, Raymond F.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Mil Psychiat Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
RP Moore, NLT (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Mil Psychiat Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM nicole.l.moore46.mil@mail.mil
FU Military Operational Medicine Research Program, US Army Medical Research
and Materiel Command
FX This study was supported by the Military Operational Medicine Research
Program, US Army Medical Research and Materiel Command. The funding
organization had no role in the writing of this article or decision to
submit for publication.
NR 61
TC 0
Z9 0
U1 3
U2 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1025-3890
EI 1607-8888
J9 STRESS
JI Stress
PD MAY
PY 2016
VL 19
IS 3
BP 295
EP 302
DI 10.1080/10253890.2016.1191465
PG 8
WC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences
SC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences &
Neurology
GA DQ0WI
UT WOS:000378922100004
PM 27295201
ER
PT J
AU Strode, MA
Sherman, W
Mangieri, CW
Bland, CM
Sparks, PJ
Faler, BJ
Prasad, BM
Choi, YU
AF Strode, Matthew A.
Sherman, William
Mangieri, Chris W.
Bland, Christopher M.
Sparks, Preston J.
Faler, Byron J.
Prasad, Balakrishna M.
Choi, Yong U.
TI Randomized trial of OFIRMEV versus placebo for pain management after
laparoscopic sleeve gastrectomy
SO SURGERY FOR OBESITY AND RELATED DISEASES
LA English
DT Article
DE Bariatric; Sleeve; Ofirmev; Pain
ID NONSTEROIDAL ANTIINFLAMMATORY DRUGS; POSTOPERATIVE PAIN; INTRAVENOUS
PARACETAMOL; DOUBLE-BLIND; SURGERY; ACETAMINOPHEN
AB Background: OFIRMEV is an intravenous form of acetaminophen approved by the Food and Drug Administration for use as an antipyretic and treatment of mild to moderate pain alone or in conjunction with opioid medications. Intravenous APAP use in postsurgical pain management has been reported to decrease opioid usage, time to rescue dose, and subjective pain.
Objectives: We used a placebo-controlled, randomized double-blind study to test the efficacy of OFIRMEV in decreasing opioid use and subjective pain after laparoscopic sleeve gastrectomy.
Setting: U.S. military training hospital.
Methods: Thirty-four patients who met criteria were enrolled and randomly assigned to 2 separate limbs of the study. The OFIRMEV and placebo groups had similar mean age ranges (48 11 and 50 +/- 11 yr) and a female/male ratio of 5:1 and 6:1, respectively. The patients received an intraoperative dose and then postoperative administration of intravenous OFIRMEV 1 g or placebo every 6 hours for 24 hours in addition to fentanyl via patient-controlled analgesia. Subjective pain scores, the total amount of fentanyl used, time to rescue of first narcotic dose, and total postanesthesia care unit (PACU) narcotic use were measured during the first 24 hours after surgery.
Results: Subjective pain score was significantly decreased compared with baseline at 12, 16, and 20 hours after surgery in OFIRMEV-treated patients but not in the placebo group. However, total narcotic use, time to rescue of first narcotic dose, and total PACU narcotic dose were not statistically different between the 2 groups.
Conclusion: Intravenous OFIRMEV use caused a modest but statistically significant decrease in subjective pain without affecting narcotic use after laparoscopic sleeve gastrectomy. (Surg Obes Relat Dis 2015;0:000-00.) (C) 2015 American Society for Metabolic and Bariatric Surgery. All rights reserved. (Surg Obes Relat Dis 2016;12:772-777.) Published by Elsevier Inc. on behalf of American Society for Metabolic and Bariatric Surgery.
C1 [Strode, Matthew A.; Sherman, William; Mangieri, Chris W.; Bland, Christopher M.; Sparks, Preston J.; Faler, Byron J.; Choi, Yong U.] Eisenhower Army Med Ctr, Dept Surg, Ft Gordon, GA USA.
[Prasad, Balakrishna M.] Eisenhower Army Med Ctr, Dept Clin Invest, Ft Gordon, GA USA.
RP Strode, MA (reprint author), 2437 River Birch Dr, Evans, GA 30809 USA.
EM Matthewallenstrode@gmail.com
NR 16
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1550-7289
EI 1878-7533
J9 SURG OBES RELAT DIS
JI Surg. Obes. Relat. Dis.
PD MAY
PY 2016
VL 12
IS 4
BP 772
EP 777
DI 10.1016/j.soard.2015.08.512
PG 6
WC Surgery
SC Surgery
GA DP3AO
UT WOS:000378365000006
PM 26525369
ER
PT J
AU Choi, Y
AF Choi, Yong
TI Comment on: Anastomotic techniques in open Roux-en-Y gastric bypass:
primary open surgery and converted procedures
SO SURGERY FOR OBESITY AND RELATED DISEASES
LA English
DT Editorial Material
ID GASTROJEJUNAL ANASTOMOSIS
C1 [Choi, Yong] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA.
RP Choi, Y (reprint author), Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA.
NR 4
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1550-7289
EI 1878-7533
J9 SURG OBES RELAT DIS
JI Surg. Obes. Relat. Dis.
PD MAY
PY 2016
VL 12
IS 4
BP 789
EP 789
PG 1
WC Surgery
SC Surgery
GA DP3AO
UT WOS:000378365000010
PM 26898672
ER
PT J
AU Hutchinson, D
Mathews, J
Sullivan, JT
Akey, A
Aziz, MJ
Buonassisi, T
Persans, P
Warrender, JM
AF Hutchinson, David
Mathews, Jay
Sullivan, Joseph T.
Akey, Austin
Aziz, Michael J.
Buonassisi, Tonio
Persans, Peter
Warrender, Jeffrey M.
TI Effect of layer thickness on device response of silicon heavily
supersaturated with sulfur
SO AIP ADVANCES
LA English
DT Article
ID ABSORPTION; BAND
AB We report on a simple experiment in which the thickness of a hyperdoped silicon layer, supersaturated with sulfur by ion implantation followed by pulsed laser melting and rapid solidification, is systematically varied at constant average sulfur concentration, by varying the implantation energy, dose, and laser fluence. Contacts are deposited and the external quantum efficiency (EQE) is measured for visible wavelengths. We posit that the sulfur layer primarily absorbs light but contributes negligible photocurrent, and we seek to support this by analyzing the EQE data for the different layer thicknesses in two interlocking ways. In the first, we use the measured concentration depth profiles to obtain the approximate layer thicknesses, and, for each wavelength, fit the EQE vs. layer thickness curve to obtain the absorption coefficient of hyperdoped silicon for that wavelength. Comparison to literature values for the hyperdoped silicon absorption coefficients [S.H. Pan et al. Applied Physics Letters 98, 121913 (2011)] shows good agreement. Next, we essentially run this process in reverse; we fit with Beer's law the curves of EQE vs. hyperdoped silicon absorption coefficient for those wavelengths that are primarily absorbed in the hyperdoped silicon layer, and find that the layer thicknesses obtained from the fit are in good agreement with the original values obtained from the depth profiles. We conclude that the data support our interpretation of the hyperdoped silicon layer as providing negligible photocurrent at high S concentrations. This work validates the absorption data of Pan et al. [Applied Physics Letters 98, 121913 (2011)], and is consistent with reports of short mobility-lifetime products in hyperdoped layers. It suggests that for optoelectronic devices containing hyperdoped layers, the most important contribution to the above band gap photoresponse may be due to photons absorbed below the hyperdoped layer. (C) 2016 Author(s).
C1 [Hutchinson, David; Persans, Peter] Rensselaer Polytech Inst, Dept Phys Appl Phys & Astron, Troy, NY 12180 USA.
[Hutchinson, David] US Mil Acad, Dept Phys & Nucl Engn, West Point, NY 10996 USA.
[Mathews, Jay; Warrender, Jeffrey M.] US Army ARDEC, Benet Labs, Watervliet, NY 12189 USA.
[Mathews, Jay] Univ Dayton, Dept Phys, Dayton, OH 45469 USA.
[Sullivan, Joseph T.; Akey, Austin; Buonassisi, Tonio] MIT, Sch Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
[Akey, Austin; Aziz, Michael J.] Harvard Univ, John A Paulson Sch Engn & Appl Sci, Cambridge, MA 02138 USA.
RP Warrender, JM (reprint author), US Army ARDEC, Benet Labs, Watervliet, NY 12189 USA.
EM jwarrend@post.harvard.edu
OI Mathews, Jay/0000-0001-5769-5382; Warrender, Jeffrey/0000-0001-6932-8344
FU Army Research Laboratory's Institute for Soldier Nanotechnology
FX We gratefully acknowledge Michael Magaletta for data collection, Daniel
Recht for technical assistance, and Harry Efstathiadis and Girish
Malladi of SUNY Polytechnic Institute(NY) for Rutherford backscattering
spectrometry data. This work was partially supported by funding through
the Army Research Laboratory's Institute for Soldier Nanotechnology.
NR 18
TC 1
Z9 1
U1 6
U2 13
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 2158-3226
J9 AIP ADV
JI AIP Adv.
PD MAY
PY 2016
VL 6
IS 5
AR 055307
DI 10.1063/1.4948986
PG 7
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary;
Physics, Applied
SC Science & Technology - Other Topics; Materials Science; Physics
GA DO7KX
UT WOS:000377962500078
ER
PT J
AU Mangieri, CW
Strode, MA
Sherman, WE
Pierotti, ML
Faler, BJ
Choi, YU
AF Mangieri, Christopher W.
Strode, Matthew A.
Sherman, William E.
Pierotti, Matthew L.
Faler, Byron J.
Choi, Yong U.
TI Institutional Improvement in Weight Loss after Laparoscopic Sleeve
Gastrectomy
SO AMERICAN SURGEON
LA English
DT Article
ID Y GASTRIC BYPASS; BARIATRIC SURGERY; LEARNING-CURVE; GUIDELINES;
EXPERIENCE; BEHAVIOR; SUCCESS; PATIENT; OBESITY; IMPACT
AB Laparoscopic sleeve gastrectomy (LSG) is a recent addition to the bariatric surgery armamentarium. It has been demonstrated to be an efficacious stand-alone bariatric procedure in regard to weight loss. This study evaluates the progress of our initial experience with LSG. Retrospective review of prospective data from 2008 to 2010. Compared data between our first operative year of experience with LSG (2008) and our third year of experience (2010). Data compared for up to three years postoperatively. End points were percentage of excess body weight loss (% EWL) and percentage of excess body mass index loss (% EBL). Institutional improvement in % EWL and % EBL rates as our collective experience increased with LSG. Mean increase in % EWL of 14 per cent and mean increase of % EBL of 22 per cent. In our first year performing LSG the institutional weight loss was < 50 per cent EWL, which is often cited as a benchmark level for "success" after bariatric surgery. By our third year of experience with LSG we achieved an institutional weight loss >50 per cent EWL. Institutional improvement in weight loss results with LSG as the collective experience increased. Several factors could have contributed to this observation to include a surgical mentorship program and the institution of formal nutritional education. This study demonstrates that institutional experience is a significant factor in weight loss results with LSG.
C1 [Mangieri, Christopher W.; Strode, Matthew A.; Sherman, William E.; Pierotti, Matthew L.; Faler, Byron J.; Choi, Yong U.] Dwight D Eisenhower Army Med Ctr, Dept Gen Surg, 300 East Hosp Rd, Ft Gordon, GA 30905 USA.
RP Mangieri, CW (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Gen Surg, 300 East Hosp Rd, Ft Gordon, GA 30905 USA.
EM christopher.w.mangieri.mil@mail.mil
NR 34
TC 0
Z9 0
U1 1
U2 1
PU SOUTHEASTERN SURGICAL CONGRESS
PI CUMMING
PA 115 SAMARITAN DR, #200, CUMMING, GA 30040-2354 USA
SN 0003-1348
EI 1555-9823
J9 AM SURGEON
JI Am. Surg.
PD MAY
PY 2016
VL 82
IS 5
BP 448
EP 455
PG 8
WC Surgery
SC Surgery
GA DO5WS
UT WOS:000377854200021
PM 27215727
ER
PT J
AU Kauvar, DS
Osborne, CL
AF Kauvar, David S.
Osborne, Candice L.
TI Discharge Destination after Elective Femoropopliteal Bypass in Patients
without Critical Ischemia
SO AMERICAN SURGEON
LA English
DT Article
ID PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; PERIOPERATIVE
MYOCARDIAL-INFARCTION; CRITICAL LIMB ISCHEMIA; LOWER-EXTREMITY BYPASS;
TERM MORTALITY-RATES; INTERMITTENT CLAUDICATION; ARTERIAL-DISEASE;
OUTCOME EVENTS; INCREASED RISK; EXERCISE
AB Femoropopliteal bypass (FPB) remains a widely accepted treatment option for symptomatic leg ischemia, even in patients without features of critical limb ischemia (CLI). These patients are revascularized to improve symptoms of exertional limb pain and the goal of such treatment is to increase their ability to ambulate within the community. Therefore, the anticipated initial discharge disposition for a patient without CLI undergoing FPB is back to their home. This study examined the disposition at initial discharge of such patients. Data from the 2012 National Surgical Quality Improvement Program registry was queried for all elective FPB performed in patients without CLI. Analysis was limited to patients surviving to initial discharge who were living independently at home before surgery. Initial disposition was defined as to HOME or to a FACILITY (either rehabilitation or skilled nursing); these constituting the study groups. Univariate analysis and multivariable logistic regression were performed to identify patient risk factors for failure to discharge to home. In-hospital and postoperative events were also recorded and compared. Significance was defined at P <= 0.05. In National Surgical Quality Improvement Program 2012, 1060 cases of elective FPB in patients without CLI were found. The mean +/- SD age of the population was 65 +/- 9 years; 359 (34%) of patients were female; 198 (19%) had a reported race other than white; and most (893, 84%) had hypertension. 60 (6%) patients failed to discharge to home (26 to rehabilitation, 34 to skilled nursing). On univariate analysis, age (FACILITY 68 +/- 11 years vs HOME 65 +/- 9 years, P = 0.009), female gender (55% vs 37%, P < 0.001), nonwhite race (30% vs 18%, P = 0.007), and a history of diabetes (48% vs 33%, P = 0.01), dialysis (5% vs 1.3%, P = 0.02) congestive heart failure (5% vs 1.1%, P = 0.01), or a stroke (cerebrovascular accident, 5% vs 2.6%, P = 0.01) were found to predict failure to discharge to home. On multivariate analysis, female gender [odds ratio (OR) = 2.4, 95% confidence interval = 1.4-4.1, P = 0.002], and a history of congestive heart failure (OR 5 4.7, 1.2-18, 0.03] or cerebrovascular accident (OR 5 3.4, 1.9-9.4, 0.02) independently predicted failure to discharge to home. FACILITY patients had higher rates of infectious complications (8.3% vs 1.4%, P < 0.001), myocardial infarction (3.3% vs 0.8%, P = 0.05), operative transfusion (22% vs 5.8%, P < 0.001), and unplanned reoperation (17% vs 2.4%, P < 0.001) during their initial hospitalization. Elective FPB results in a low but not negligible failure of initial return to the community in patients without CLI. Female gender and serious comorbidities predict initial discharge to a facility, which is associated with a complicated hospital course. Careful patient selection is important to achieve good outcomes in this population and furthermore study into the specific preoperative functional and socioeconomic factors predicting failure of early return to the community is warranted.
C1 [Kauvar, David S.] Dwight D Eisenhower Army Med Ctr, Vasc Surg Serv, Ft Gordon, GA USA.
[Kauvar, David S.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Osborne, Candice L.] Univ Texas Med Branch, Dept Rehabil Sci, Galveston, TX 77555 USA.
RP Kauvar, DS (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Surg, 300 Hosp Dr, Ft Gordon, GA 30905 USA.
EM davekauvar@gmail.com
NR 19
TC 0
Z9 0
U1 0
U2 0
PU SOUTHEASTERN SURGICAL CONGRESS
PI CUMMING
PA 115 SAMARITAN DR, #200, CUMMING, GA 30040-2354 USA
SN 0003-1348
EI 1555-9823
J9 AM SURGEON
JI Am. Surg.
PD MAY
PY 2016
VL 82
IS 5
BP 462
EP 467
PG 6
WC Surgery
SC Surgery
GA DO5WS
UT WOS:000377854200023
PM 27215729
ER
PT J
AU Hart, CR
Reznicek, NJ
Wilson, DK
Pettit, CL
Nykaza, ET
AF Hart, Carl R.
Reznicek, Nathan J.
Wilson, D. Keith
Pettit, Chris L.
Nykaza, Edward T.
TI Comparisons between physics-based, engineering, and statistical learning
models for outdoor sound propagation
SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
LA English
DT Article
ID ATMOSPHERIC SURFACE-LAYER; FEEDFORWARD NETWORKS; TRANSMISSION LOSS;
HARMONOISE; IMPEDANCE; PREDICTION; GRADIENTS; TUTORIAL; BARRIER
AB Many outdoor sound propagation models exist, ranging from highly complex physics-based simulations to simplified engineering calculations, and more recently, highly flexible statistical learning methods. Several engineering and statistical learning models are evaluated by using a particular physics-based model, namely, a Crank-Nicholson parabolic equation (CNPE), as a benchmark. Narrowband transmission loss values predicted with the CNPE, based upon a simulated data set of meteorological, boundary, and source conditions, act as simulated observations. In the simulated data set sound propagation conditions span from downward refracting to upward refracting, for acoustically hard and soft boundaries, and low frequencies. Engineering models used in the comparisons include the ISO 9613-2 method, Harmonoise, and Nord2000 propagation models. Statistical learning methods used in the comparisons include bagged decision tree regression, random forest regression, boosting regression, and artificial neural network models. Computed skill scores are relative to sound propagation in a homogeneous atmosphere over a rigid ground. Overall skill scores for the engineering noise models are 0.6%, -7.1%, and 83.8% for the ISO 9613-2, Harmonoise, and Nord2000 models, respectively. Overall skill scores for the statistical learning models are 99.5%, 99.5%, 99.6%, and 99.6% for bagged decision tree, random forest, boosting, and artificial neural network regression models, respectively.
C1 [Hart, Carl R.; Reznicek, Nathan J.; Wilson, D. Keith] US Army Cold Reg Res & Engn Lab, Engn Res & Dev Ctr, Hanover, NH 03755 USA.
[Pettit, Chris L.] US Naval Acad, Dept Aerosp Engn, Annapolis, MD 21402 USA.
[Nykaza, Edward T.] US Army Construct Engn Res Lab, Engn Res & Dev Ctr, Champaign, IL 61826 USA.
RP Hart, CR (reprint author), US Army Cold Reg Res & Engn Lab, Engn Res & Dev Ctr, Hanover, NH 03755 USA.
EM carl.r.hart@usace.army.mil
RI Wilson, D. Keith/A-4687-2012
OI Wilson, D. Keith/0000-0002-8020-6871
FU U.S. Department of Energy; ERDC-CRREL
FX We thank Dirk van Maercke (CSTB) for providing version 2.022 of the
Harmonoise point-to-point propagation algorithm. We also thank the
anonymous reviewers and associate editor for their valuable feedback.
This research was supported in part by an appointment (CRH) to the
Student Research Participation Program at the U.S. Army Engineer
Research and Development Center-Cold Regions Research and Engineering
Laboratory (ERDC-CRREL) administered by the Oak Ridge Institute for
Science and Education through an interagency agreement between the U.S.
Department of Energy and ERDC-CRREL. Permission to publish was granted
by Director, ERDC-CRREL.
NR 51
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U1 4
U2 5
PU ACOUSTICAL SOC AMER AMER INST PHYSICS
PI MELVILLE
PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA
SN 0001-4966
EI 1520-8524
J9 J ACOUST SOC AM
JI J. Acoust. Soc. Am.
PD MAY
PY 2016
VL 139
IS 5
BP 2640
EP 2655
DI 10.1121/1.4948757
PG 16
WC Acoustics; Audiology & Speech-Language Pathology
SC Acoustics; Audiology & Speech-Language Pathology
GA DO3XF
UT WOS:000377715100047
PM 27250158
ER
PT J
AU Zollner, G
Sattabongkot, J
Vaughan, JA
Kankaew, P
Robert, LL
Thimasarn, K
Sithiprasasna, R
Coleman, RE
AF Zollner, Gabriela
Sattabongkot, Jetsumon
Vaughan, Jefferson A.
Kankaew, Prasan
Robert, Leon L.
Thimasarn, Krongthong
Sithiprasasna, Ratana
Coleman, Russell E.
TI LONGITUDINAL EVALUATION OF MALARIA EPIDEMIOLOGY IN AN ISOLATED VILLAGE
IN WESTERN THAILAND: I. STUDY SITE AND ADULT ANOPHELINE BIONOMICS
SO SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH
LA English
DT Article
DE malaria epidemiology; anopheline bionomics; western Thailand
ID FALCIPARUM/VIVAX ENDEMIC AREA; LINKED-IMMUNOSORBENT-ASSAY;
PLASMODIUM-VIVAX; ASYMPTOMATIC MALARIA; BARBIROSTRIS COMPLEX; SEASONAL
ABUNDANCE; DIPTERA-CULICIDAE; SOUTHERN THAILAND; DIRUS MOSQUITOS; BITING
ACTIVITY
AB This is the first in a series of papers describing the epidemiology of malaria in an isolated village in western Thailand. The study site was the village of Kong Mong Tha, located in Sangkhla Bun District, Kanchanaburi Province, Thailand. In this paper we present an overview of the study site and results from our adult anopheline mosquito surveillance conducted over 56 consecutive months from June 1999 until January 2004. The collection site, indoor/outdoor location, parity, biting activity and Plasmodium falciparum (Pf) and P. vivax (Pv) infection rates were used to calculate seasonal entomological inoculation rates for the predominant four Anopheles species. A total of 21,566 anophelines representing 28 distinct species and 2 groups that were not identified to species were collected using human bait, with almost 95% of the collection consisting of Anopheles minimus, An. maculatus, An. sawadwongporni and An. barbirostris/campestris. Mosquitoes generally peaked during the wet season, were collected throughout the night, and were collected most often outside (ca. 75%) versus inside (ca. 25%) of houses. Approximately 50% of collected mosquitoes were parous. Overall Plasmodium infection rates were 0.27%, with a total of 16 and 42 pools of Pf- and Pv-positive mosquitoes, respectively. Annual EIRs were 2.3 times higher for Pv than for Pf, resulting in approximately 5.5 and 2.6 infective bites per person per year, respectively. The results suggest An. minimus and An. maculatus are the primary and secondary vectors of Pf and Pv transmission in Kong Mong Tha, while An. sawadwongporni and An. barbirostris/campestris also appear to play a role based on the presence of circumsporozoite protein (CSP) in the head/thorax of the specimens tested.
C1 [Zollner, Gabriela; Sattabongkot, Jetsumon; Kankaew, Prasan; Sithiprasasna, Ratana; Coleman, Russell E.] US Army Med Component, Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok, Thailand.
[Vaughan, Jefferson A.] Univ N Dakota, Dept Biol, Grand Forks, ND 58202 USA.
[Robert, Leon L.] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA.
[Thimasarn, Krongthong] Minist Publ Hlth, Dept Communicable Dis Control, Malaria Div, Nonthaburi, Thailand.
RP Coleman, RE (reprint author), Joint Project Management Off, 1564 Freedman Dr, Ft Detrick, MD 21702 USA.
EM Russell.coleman@us.army.mil
FU NIH grant [AI48813]; Military Infectious Diseases Research Program of
the US Army Medical Research and Materiel Command; Fort Detrick,
Maryland; National Research Council Associateship Award at AFRIMS
FX The willing assistance of the villagers in Kong Mong Tha is greatly
appreciated. We are grateful to Ampornpan Kengluecha, Chalermpol
Kumpitak, Chukree Kiattibut, Nantavadee Suwanabun, Patcharee Khongtak,
Somporn Chanaimongkol, Somsak Tiangtrong and Suda Ratanawong for
providing technical assistance and expertise in the field and
laboratory. Funding for this project was provided by the NIH grant
AI48813 and by the Military Infectious Diseases Research Program of the
US Army Medical Research and Materiel Command, Fort Detrick, Maryland.
The work was performed while G Zollner held a National Research Council
Associateship Award at AFRIMS.
NR 66
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Z9 0
U1 2
U2 3
PU SOUTHEAST ASIAN MINISTERS EDUC ORGANIZATION
PI BANGKOK
PA SEAMEO-TROPMED, 420-6 RAJVITHI RD,, BANGKOK 10400, THAILAND
SN 0125-1562
J9 SE ASIAN J TROP MED
JI Southeast Asian J. Trop. Med. Public Health
PD MAY
PY 2016
VL 47
IS 3
BP 341
EP 365
PG 25
WC Public, Environmental & Occupational Health; Infectious Diseases;
Tropical Medicine
SC Public, Environmental & Occupational Health; Infectious Diseases;
Tropical Medicine
GA DO8DI
UT WOS:000378012400001
PM 27405117
ER
PT J
AU Hoekman, D
Springer, YP
Barker, CM
Barrera, R
Blackmore, MS
Bradshaw, WE
Foley, DH
Ginsberg, HS
Hayden, MH
Holzapfel, CM
Juliano, SA
Kramer, LD
LaDeau, SL
Livdahl, TP
Moore, CG
Nasci, RS
Reisen, WK
Savage, HM
AF Hoekman, D.
Springer, Y. P.
Barker, C. M.
Barrera, R.
Blackmore, M. S.
Bradshaw, W. E.
Foley, D. H.
Ginsberg, H. S.
Hayden, M. H.
Holzapfel, C. M.
Juliano, S. A.
Kramer, L. D.
LaDeau, S. L.
Livdahl, T. P.
Moore, C. G.
Nasci, R. S.
Reisen, W. K.
Savage, H. M.
TI Design for mosquito abundance, diversity, and phenology sampling within
the National Ecological Observatory Network
SO ECOSPHERE
LA English
DT Article
DE abundance; climate; Culicidae; diversity; global change; long-term
monitoring; mosquito; phenology; Special Feature: NEON Design
ID WEST-NILE-VIRUS; AEDES-ALBOPICTUS; BORNE DISEASES; KERN COUNTY; CLIMATE;
TRAPS; SURVEILLANCE; ENVIRONMENT; CALIFORNIA; CATCHES
AB The National Ecological Observatory Network (NEON) intends to monitor mosquito populations across its broad geographical range of sites because of their prevalence in food webs, sensitivity to abiotic factors, and relevance for human health. We describe the design of mosquito population sampling in the context of NEON's long-term continental scale monitoring program, emphasizing the sampling design schedule, priorities, and collection methods. Freely available NEON data and associated field and laboratory samples, will increase our understanding of how mosquito abundance, demography, diversity, and phenology are responding to land use and climate change.
C1 [Hoekman, D.; Springer, Y. P.] Natl Ecol Observ Network NEON Inc, 1685 38th St Suite 100, Boulder, CO 80301 USA.
[Springer, Y. P.; Nasci, R. S.; Savage, H. M.] US Ctr Dis Control & Prevent, Div Vector Borne Dis, 3156 Rampart Rd, Ft Collins, CO 80521 USA.
[Barker, C. M.; Reisen, W. K.] Univ Calif Davis, Sch Vet Med, Ctr Vectorborne Dis, Davis, CA 95616 USA.
[Barker, C. M.; Reisen, W. K.] Univ Calif Davis, Sch Vet Med, Dept Pathol Microbiol & Immunol, Davis, CA 95616 USA.
[Barrera, R.] US Ctr Dis Control & Prevent, Div Vector Borne Dis, 1324 Calle Canada, San Juan, PR 00969 USA.
[Blackmore, M. S.] Valdosta State Univ, Dept Biol, Valdosta, GA 31698 USA.
[Bradshaw, W. E.; Holzapfel, C. M.] Univ Oregon, Inst Ecol & Evolut, Eugene, OR 97403 USA.
[Foley, D. H.] Walter Reed Army Inst Res, Walter Reed Biosystemat Unit, Div Entomol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
[Ginsberg, H. S.] Univ Rhode Isl, US Geol Survey, Patuxent Wildlife Res Ctr, Coastal Field Stn,PSE, Woodward Hall, Kingston, RI 02881 USA.
[Hayden, M. H.] Natl Ctr Atmospher Res, POB 3000, Boulder, CO 80307 USA.
[Juliano, S. A.] Illinois State Univ, Sch Biol Sci, Normal, IL 61790 USA.
[Kramer, L. D.] New York State Dept Hlth, Arbovirus Lab, Wadsworth Ctr, Slingerlands, NY 12159 USA.
[Kramer, L. D.] SUNY Albany, Sch Publ Hlth, Albany, NY 12201 USA.
[LaDeau, S. L.] Cary Inst Ecosyst Studies, 2801 Sharon Turnpike, Millbrook, NY 12545 USA.
[Livdahl, T. P.] Clark Univ, Dept Biol, Worcester, MA 01610 USA.
[Moore, C. G.] Colorado State Univ, Dept Microbiol Immunol & Pathol, 1690 Campus Delivery, Ft Collins, CO 80523 USA.
[Hoekman, D.] Southern Nazarene Univ, Dept Biol, 6729 NW 39th Expressway, Bethany, OK 73008 USA.
[Nasci, R. S.] North Shore Mosquito Abatement Dist, 117 Northfield Rd, Northfield, IL 60093 USA.
RP Hoekman, D (reprint author), Natl Ecol Observ Network NEON Inc, 1685 38th St Suite 100, Boulder, CO 80301 USA.; Hoekman, D (reprint author), Southern Nazarene Univ, Dept Biol, 6729 NW 39th Expressway, Bethany, OK 73008 USA.
EM dhoekman@snu.edu
OI Foley, Desmond/0000-0001-7525-4601
FU National Science Foundation [EF-1029808]
FX The National Ecological Observatory Network is a project sponsored by
the National Science Foundation and managed under cooperative agreement
by NEON Inc. This material is based upon work supported by the National
Science Foundation under Cooperative Service Agreement EF-1029808. Any
opinions, findings, conclusions or recommendations expressed here are
those of the authors and do not necessarily reflect the views of NEON
Inc., the NSF, the United States Centers for Disease Control and
Prevention, the United States Geological Survey, the United States
Department of the Army, or the United States Department of Defense. Use
of trade or product names does not imply endorsement by the U.S.
Government. The authors acknowledge K.K. Blevins and C.M. Gibson for
contributions to early drafts of the design as well as members of the
terrestrial observation system group at NEON for formal and informal
input during the iteration process. Comments from two anonymous
reviewers improved the manuscript and we are grateful to Dr. E.-L.S.
Hinckley for coordinating its review.
NR 46
TC 0
Z9 0
U1 11
U2 18
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2150-8925
J9 ECOSPHERE
JI Ecosphere
PD MAY
PY 2016
VL 7
IS 5
AR e01320
DI 10.1002/ecs2.1320
PG 13
WC Ecology
SC Environmental Sciences & Ecology
GA DN6VS
UT WOS:000377215200029
ER
PT J
AU Springer, YP
Hoekman, D
Johnson, PTJ
Duffy, PA
Hufft, RA
Barnett, DT
Allan, BF
Amman, BR
Barker, CM
Barrera, R
Beard, CB
Beati, L
Begon, M
Blackmore, MS
Bradshaw, WE
Brisson, D
Calisher, CH
Childs, JE
Diuk-Wasser, MA
Douglass, RJ
Eisen, RJ
Foley, DH
Foley, JE
Gaff, HD
Gardner, SL
Ginsberg, HS
Glass, GE
Hamer, SA
Hayden, MH
Hjelle, B
Holzapfel, CM
Juliano, SA
Kramer, LD
Kuenzi, AJ
LaDeau, SL
Livdahl, TP
Mills, JN
Moore, CG
Morand, S
Nasci, RS
Ogden, NH
Ostfeld, RS
Parmenter, RR
Piesman, J
Reisen, WK
Savage, HM
Sonenshine, DE
Swei, A
Yabsley, MJ
AF Springer, Yuri P.
Hoekman, David
Johnson, Pieter T. J.
Duffy, Paul A.
Hufft, Rebecca A.
Barnett, David T.
Allan, Brian F.
Amman, Brian R.
Barker, Christopher M.
Barrera, Roberto
Beard, Charles B.
Beati, Lorenza
Begon, Mike
Blackmore, Mark S.
Bradshaw, William E.
Brisson, Dustin
Calisher, Charles H.
Childs, James E.
Diuk-Wasser, Maria A.
Douglass, Richard J.
Eisen, Rebecca J.
Foley, Desmond H.
Foley, Janet E.
Gaff, Holly D.
Gardner, Scott L.
Ginsberg, Howard S.
Glass, Gregory E.
Hamer, Sarah A.
Hayden, Mary H.
Hjelle, Brian
Holzapfel, Christina M.
Juliano, Steven A.
Kramer, Laura D.
Kuenzi, Amy J.
LaDeau, Shannon L.
Livdahl, Todd P.
Mills, James N.
Moore, Chester G.
Morand, Serge
Nasci, Roger S.
Ogden, Nicholas H.
Ostfeld, Richard S.
Parmenter, Robert R.
Piesman, Joseph
Reisen, William K.
Savage, Harry M.
Sonenshine, Daniel E.
Swei, Andrea
Yabsley, Michael J.
TI Tick-, mosquito-, and rodent-borne parasite sampling designs for the
National Ecological Observatory Network
SO ECOSPHERE
LA English
DT Article
DE infectious disease; mosquito; National Ecological Observatory Network;
NEON design; parasite; pathogen; reservoir; rodent; sampling design;
Special Feature: NEON Design; tick; vector; zoonoses
ID WEST-NILE-VIRUS; SIN-NOMBRE-VIRUS; HANTAVIRUS PULMONARY SYNDROME;
EMERGING INFECTIOUS-DISEASES; IXODES-SCAPULARIS ACARI; SOUTHWESTERN
UNITED-STATES; AMBLYOMMA-AMERICANUM ACARI; FIELD-COLLECTED MOSQUITOS;
LAND-USE CHANGE; CLIMATE-CHANGE
AB Parasites and pathogens are increasingly recognized as significant drivers of ecological and evolutionary change in natural ecosystems. Concurrently, transmission of infectious agents among human, livestock, and wildlife populations represents a growing threat to veterinary and human health. In light of these trends and the scarcity of long-term time series data on infection rates among vectors and reservoirs, the National Ecological Observatory Network (NEON) will collect measurements and samples of a suite of tick-, mosquito-, and rodent-borne parasites through a continental-scale surveillance program. Here, we describe the sampling designs for these efforts, highlighting sampling priorities, field and analytical methods, and the data as well as archived samples to be made available to the research community. Insights generated by this sampling will advance current understanding of and ability to predict changes in infection and disease dynamics in novel, interdisciplinary, and collaborative ways.
C1 [Springer, Yuri P.; Hoekman, David; Barnett, David T.] Natl Ecological Observ Network NEON Inc, 1685 38th St Suite 100, Boulder, CO 80301 USA.
[Springer, Yuri P.; Beard, Charles B.; Eisen, Rebecca J.; Nasci, Roger S.; Piesman, Joseph; Savage, Harry M.] US Ctr Dis Control & Prevent, Div Vector Borne Dis, 3150 Rampart Rd, Ft Collins, CO 80521 USA.
[Hoekman, David] Southern Nazarene Univ, Dept Biol, 6729 NW 29th Expy, Bethany, OK 73008 USA.
[Johnson, Pieter T. J.] Univ Colorado, Dept Ecol & Evolutionary Biol, Ramaley N122, Boulder, CO 80309 USA.
[Duffy, Paul A.] Neptune & Co Inc, 1435 Garrison St Suite 100, Lakewood, CO 80215 USA.
[Hufft, Rebecca A.] Denver Bot Gardens, 909 York St, Denver, CO 80206 USA.
[Allan, Brian F.] Univ Illinois, Dept Entomol, Urbana, IL 61801 USA.
[Amman, Brian R.] Natl Ctr Emerging & Zoonot Infect Dis, Div High Consequence Pathogens & Pathol, Viral Special Pathogens Branch, US Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
[Barker, Christopher M.; Reisen, William K.] Univ Calif Davis, Sch Vet Med, Ctr Vectorborne Dis, Davis, CA 95616 USA.
[Barker, Christopher M.; Reisen, William K.] Univ Calif Davis, Sch Vet Med, Dept Pathol Microbiol & Immunol, Davis, CA 95616 USA.
[Barrera, Roberto] US Ctr Dis Control & Prevent, Div Vector Borne Dis, 1324 Calle Canada, San Juan, PR 00969 USA.
[Beati, Lorenza] Georgia So Coll, Inst Arthropodol & Parasitol, Georgia Ave,Bldg 204,POB 8056, Statesboro, GA 30460 USA.
[Begon, Mike] Univ Liverpool, IIB, Liverpool L69 7ZB, Merseyside, England.
[Blackmore, Mark S.] Valdosta State Univ, Dept Biol, Valdosta, GA 31698 USA.
[Bradshaw, William E.; Holzapfel, Christina M.] Univ Oregon, Inst Ecol & Evolut, Eugene, OR 97403 USA.
[Brisson, Dustin] Univ Penn, Dept Biol, Evolut & Ecol Dis Syst Lab, 209 Leidy Labs, 433 S Univ Ave, Philadelphia, PA 19104 USA.
[Calisher, Charles H.] Colorado State Univ, Arthropod Borne & Infect Dis Lab, Dept Microbiol Immunol & Pathol, Coll Vet Med & Biomed Sci, 3195 Rampart Rd,Foothills Campus, Ft Collins, CO 80523 USA.
[Childs, James E.] Yale Univ, Sch Publ Hlth, Dept Epidemiol & Microbiol, New Haven, CT 06520 USA.
[Diuk-Wasser, Maria A.] Columbia Univ, Dept Ecol Evolut & Environm Biol, 1200 Amsterdam Ave, New York, NY 10027 USA.
[Douglass, Richard J.; Kuenzi, Amy J.] Montana Tech Univ, Dept Biol Sci, Butte, MT 59701 USA.
[Foley, Desmond H.] Walter Reed Army Inst Res, Div Entomol, Walter Reed Biosystemat Unit, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
[Foley, Janet E.] Univ Calif Davis, Sch Vet Med, Dept Med & Epidemiol, Davis, CA 95616 USA.
[Gaff, Holly D.; Sonenshine, Daniel E.] Old Dominion Univ, Dept Biol Sci, Norfolk, VA 23529 USA.
[Gardner, Scott L.] Univ Nebraska, State Museum, Harold W Manter Lab Parasitol, Lincoln, NE 68588 USA.
[Ginsberg, Howard S.] Univ Rhode Isl, PSE, Patuxent Wildlife Res Ctr, US Geol Survey,Coastal Field Stn, Woodward Hall, Kingston, RI 02881 USA.
[Glass, Gregory E.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA.
[Hamer, Sarah A.] Texas A&M Univ, Dept Vet Integrat Biosci, College Stn, TX 77843 USA.
[Hayden, Mary H.] Natl Ctr Atmospher Res, POB 3000, Boulder, CO 80307 USA.
[Hjelle, Brian] Univ New Mexico HSC, Dept Pathol, Albuquerque, NM 87131 USA.
[Hjelle, Brian] Univ New Mexico HSC, Dept Biol, Albuquerque, NM 87131 USA.
[Hjelle, Brian] Univ New Mexico HSC, Dept Mol Genet & Microbiol, Albuquerque, NM 87131 USA.
[Juliano, Steven A.] Illinois State Univ, Sch Biol Sci, Normal, IL 61790 USA.
[Kramer, Laura D.] New York State Dept Hlth Slingerlands, Arbovirus Labs Wadsworth Ctr, New York, NY 12159 USA.
[Kramer, Laura D.] SUNY Albany, Sch Publ Hlth, Albany, NY 12201 USA.
[LaDeau, Shannon L.; Ostfeld, Richard S.] Cary Inst Ecosyst Studies, 2801 Sharon Turnpike, Millbrook, NY 12545 USA.
[Livdahl, Todd P.] Clark Univ, Dept Biol, Worcester, MA 01610 USA.
[Mills, James N.] Emory Univ, Populat Biol Ecol & Evolut Program, 1335 Springdale Rd, Atlanta, GA 30306 USA.
[Moore, Chester G.] Colorado State Univ, Dept Microbiol Immunol & Pathol, 1690 Campus Delivery, Ft Collins, CO 80523 USA.
[Morand, Serge] Ctr Infectiol Christophe Merieux Laos, CNRS CIRAD AGIRs, Viangchan, Laos.
[Ogden, Nicholas H.] Publ Hlth Agcy Canada, 3200 Sicotte, St Hyacinthe, PQ J2S 7C6, Canada.
[Parmenter, Robert R.] Valles Caldera Natl Preserve, POB 359, Jemez Springs, NM 87025 USA.
[Swei, Andrea] San Francisco State Univ, Dept Biol, San Francisco, CA 94132 USA.
[Yabsley, Michael J.] Univ Georgia, Coll Vet Med, Dept Populat Hlth, Warnell Sch Forestry & Nat Resources, Athens, GA 30605 USA.
[Yabsley, Michael J.] Univ Georgia, Southeastern Cooperat Wildlife Dis Study, Athens, GA 30605 USA.
[Springer, Yuri P.] Venice Bike Fix, 1101 Ocean Front Walk, Venice, CA 90291 USA.
RP Springer, YP (reprint author), Natl Ecological Observ Network NEON Inc, 1685 38th St Suite 100, Boulder, CO 80301 USA.
EM yurispringer@gmail.com
OI Foley, Desmond/0000-0001-7525-4601
FU National Science Foundation; RRA grant [DBI-0752017]
FX The NEON is a project sponsored by the National Science Foundation. At
the time this paper was written, the project was managed under
cooperative agreement by NEON, Inc. The material presented in this paper
is based on work supported by the National Science Foundation under
Cooperative Service Agreement and RRA grant DBI-0752017. Any opinions,
findings, conclusions or recommendations expressed here are those of the
authors and do not necessarily reflect the views of NEON, Inc., the
National Science Foundation, the U.S. Centers for Disease Control and
Prevention, the U.S. Department of the Army, or the U.S. Department of
Defense. Similarly, changes to the designs proposed herein during
implementation by NEON, Inc. do not necessarily reflect the scientific
recommendations of the authors. This article and the designs presented
within it were developed and written when Y.P. Springer and D. Hoekman
were employed as the disease and insect ecologists, respectively, at
NEON, Inc. The authors gratefully acknowledge C.M. Gibson and V.J.
McKenzie for their contributions to early versions of these designs, and
E.L.S. Hinckley and S.V. Ollinger for publication support. We also thank
scientists and technicians of the NEON terrestrial observation systems
team for their collaborative efforts to create the larger NEON
terrestrial sampling plan of which these designs are a part. W. Barnett
assisted with the writing of the power analysis code. Comments from J.R.
Sauer, S.R. Campbell, S.C. Elmendorf, E.L.S. Hinckley, K.E. Levan, and
two anonymous reviewers improved the manuscript. Any use of trade, firm,
or product names is for descriptive purposes only and does not imply
endorsement by the U.S. Government. NEON working group members are as
follows: Tick and tick-borne parasite technical working group: B. F.
Allan, C. B. Beard, L. B. Dustin Brisson, M. A. Diuk-Wasser, R. J.
Eisen, H. D. Gaff, S. A. Hamer, N. H. Ogden, R. S. Ostfeld, J. Piesman,
D. E. Sonenshine, A. Swei, and M. J. Yabsley; Mosquito and
mosquito-borne parasite technical working group: C. M. Barker, R.
Barrera, M. S. Blackmore, W. E. Bradshaw, D. H. Foley, H. S. Ginsberg,
M. H. Hayden, C. M. Holzapfel, S. A. Juliano, L. D. Kramer, S. L.
LaDeau, T. P. Livdahl, C. G. Moore, R. S. Nasci, W. K. Reisen, and H. M.
Savage; Rodent-borne parasite technical working group: M. Begon, C. H.
Calisher, J. E. Childs, R. J. Douglass, J. E. Foley, S. L. Gardner, G.
E. Glass, B. Hjelle, A. J. Kuenzi, J. N. Mills, S. Morand, and R. R.
Parmenter.
NR 242
TC 1
Z9 1
U1 12
U2 17
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2150-8925
J9 ECOSPHERE
JI Ecosphere
PD MAY
PY 2016
VL 7
IS 5
AR e01271
DI 10.1002/ecs2.1271
PG 40
WC Ecology
SC Environmental Sciences & Ecology
GA DN6VS
UT WOS:000377215200011
ER
PT J
AU Dunn, JC
Kusnezov, N
Orr, JD
Pallis, M
Mitchell, JS
AF Dunn, John C.
Kusnezov, Nicholas
Orr, Justin D.
Pallis, Mark
Mitchell, Justin S.
TI The Boxer's Fracture: Splint Immobilization Is Not Necessary
SO ORTHOPEDICS
LA English
DT Article
ID 5TH METACARPAL; SUBCAPITAL FRACTURES; FINGER METACARPAL; NECK;
REPOSITION; HAND; 4TH
AB Fractures of the fifth metacarpal neck, or boxer's fractures, are common, particularly among young men. Because of the high frequency of this injury, there is a considerable range of treatment options. The purpose of this systematic review was to determine whether reduction and splint or cast immobilization is necessary for fractures of the fifth metacarpal neck. The authors conducted a systematic review of all published studies that randomized these fractures to cast immobilization vs treatment with soft wrap without reduction. Cast immobilization is not superior to soft wrap without reduction in most cases. The study found that reduction and cast immobilization is not necessary for boxer's fractures.
C1 [Dunn, John C.; Kusnezov, Nicholas; Orr, Justin D.; Pallis, Mark; Mitchell, Justin S.] William Beaumont Army Med Ctr, Dept Orthopaed Surg, 5005 N Piedras, Ft Bliss, TX 79920 USA.
RP Dunn, JC (reprint author), William Beaumont Army Med Ctr, Dept Orthopaed Surg, 5005 N Piedras, Ft Bliss, TX 79920 USA.
EM dunnjohnc@gmail.com
NR 29
TC 1
Z9 1
U1 1
U2 1
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 0147-7447
EI 1938-2367
J9 ORTHOPEDICS
JI Orthopedics
PD MAY-JUN
PY 2016
VL 39
IS 3
BP 188
EP 192
DI 10.3928/01477447-20160315-05
PG 5
WC Orthopedics
SC Orthopedics
GA DO1DR
UT WOS:000377519200042
PM 27018606
ER
PT J
AU Waterman, BR
Martin, KD
Cameron, KL
Owens, BD
Belmont, PJ
AF Waterman, Brian R.
Martin, Kevin D.
Cameron, Kenneth L.
Owens, Brett D.
Belmont, Philip J., Jr.
TI Simulation Training Improves Surgical Proficiency and Safety During
Diagnostic Shoulder Arthroscopy Performed by Residents
SO ORTHOPEDICS
LA English
DT Article
ID SKILLS; SURGERY; TRIAL
AB Although virtual reality simulators have established construct validity, no studies have proven transfer of skills from a simulator to improved in vivo surgical skill. The current authors hypothesized that simulation training would improve residents' basic arthroscopic performance and safety. Twenty-two orthopedic surgery trainees were randomized into simulation or standard practice groups. At baseline testing, all of the participants performed simulator-based testing and a supervised, in vivo diagnostic shoulder arthroscopy with video recording. The simulation group subsequently received 1 hour of total instruction during a 3-month period, and the standard practice group received no simulator training. After intervention, both groups were reevaluated with simulator testing and a second recorded diagnostic shoulder arthroscopy. Two blinded, independent experts evaluated arthroscopic performance using the anatomic checklist, Arthroscopic Surgery Skill Evaluation Tool (ASSET) score, and total elapsed time. All outcome measures were compared within and between groups. After intervention, mean time required by the simulation group to complete the simulator task (30.64 seconds) was 8 +/- 1.2 seconds faster than the time required by the control group (38.64 seconds; P=. 001). Probe distance (51.65 mm) was improved by 41.2 +/- 6.08 mm compared with the control (92.83 mm; P=. 001). When comparing ASSET safety scores, the simulation group was competent (3.29) and significantly better than the control group (3.00; P=. 005) during final arthroscopic testing. This study establishes transfer validity for an arthroscopic shoulder simulator model. Simulator training for residents in training can decrease surgical times, improve basic surgical skills, and confer greater patient safety during shoulder arthroscopy.
C1 [Waterman, Brian R.; Martin, Kevin D.; Belmont, Philip J., Jr.] William Beaumont Army Med Ctr, Dept Orthopaed Surg & Rehabil, El Paso, TX 79920 USA.
[Cameron, Kenneth L.; Owens, Brett D.] US Mil Acad, Keller Army Hosp, 900 Washington Rd, West Point, NY 10996 USA.
RP Owens, BD (reprint author), US Mil Acad, Keller Army Hosp, 900 Washington Rd, West Point, NY 10996 USA.
EM owensbrett@gmail.com
FU Mitek; US Army Central Simulation Committee
FX Drs Waterman, Martin, Cameron, and Belmont have no relevant financial
relationships to disclose. Dr Owens is a paid consultant for Mitek.; The
authors thank the US Army Central Simulation Committee for support with
this investigation.
NR 19
TC 1
Z9 1
U1 2
U2 2
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 0147-7447
EI 1938-2367
J9 ORTHOPEDICS
JI Orthopedics
PD MAY-JUN
PY 2016
VL 39
IS 3
BP E479
EP E485
DI 10.3928/01477447-20160427-02
PG 7
WC Orthopedics
SC Orthopedics
GA DO1DR
UT WOS:000377519200013
PM 27135460
ER
PT J
AU Sobarzo, A
Stonier, SW
Herbert, AS
Ochayon, DE
Kuehne, AI
Eskira, Y
Fedida-Metula, S
Tali, N
Lewis, EC
Egesa, M
Cose, S
Lutwama, JJ
Yavelsky, V
Dye, JM
Lobel, L
AF Sobarzo, Ariel
Stonier, Spencer W.
Herbert, Andrew S.
Ochayon, David E.
Kuehne, Ana I.
Eskira, Yael
Fedida-Metula, Shlomit
Tali, Neta
Lewis, Eli C.
Egesa, Moses
Cose, Stephen
Lutwama, Julius Julian
Yavelsky, Victoria
Dye, John M.
Lobel, Leslie
TI Correspondence of Neutralizing Humoral Immunity and CD4 T Cell Responses
in Long Recovered Sudan Virus Survivors
SO VIRUSES-BASEL
LA English
DT Article
DE Ebola survivors; memory immunity; neutralizing antibodies; cellular
immunity
ID EBOLA-VIRUS; INFLAMMATORY RESPONSES; CHEMOKINE RECEPTORS; INFECTION;
DISEASE; PERSISTENCE; OUTBREAKS; HUMANS; UGANDA; GULU
AB Robust humoral and cellular immunity are critical for survival in humans during an ebolavirus infection. However, the interplay between these two arms of immunity is poorly understood. To address this, we examined residual immune responses in survivors of the Sudan virus (SUDV) outbreak in Gulu, Uganda (2000-2001). Cytokine and chemokine expression levels in SUDV stimulated whole blood cultures were assessed by multiplex ELISA and flow cytometry. Antibody and corresponding neutralization titers were also determined. Flow cytometry and multiplex ELISA results demonstrated significantly higher levels of cytokine and chemokine responses in survivors with serological neutralizing activity. This correspondence was not detected in survivors with serum reactivity to SUDV but without neutralization activity. This previously undefined relationship between memory CD4 T cell responses and serological neutralizing capacity in SUDV survivors is key for understanding long lasting immunity in survivors of filovirus infections.
C1 [Sobarzo, Ariel; Eskira, Yael; Fedida-Metula, Shlomit; Tali, Neta; Yavelsky, Victoria; Lobel, Leslie] Ben Gurion Univ Negev, Dept Microbiol Immunol & Genet, Fac Hlth Sci, IL-84105 Beer Sheva, Israel.
[Stonier, Spencer W.; Herbert, Andrew S.; Kuehne, Ana I.; Dye, John M.] US Army Med Res Inst Infect Dis, Div Virol, 1425 Porter St, Frederick, MD 21701 USA.
[Ochayon, David E.; Lewis, Eli C.] Ben Gurion Univ Negev, Dept Clin Biochem & Pharmacol, Fac Hlth Sci, IL-84105 Beer Sheva, Israel.
[Egesa, Moses; Cose, Stephen] MRC, Uganda Virus Res Inst, Uganda Res Unit AIDS, POB 49, Entebbe, Uganda.
[Egesa, Moses] Makerere Univ, Dept Med Microbiol, Sch Biomed Sci, Coll Hlth Sci, POB 7072, Kampala, Uganda.
[Cose, Stephen] London Sch Hyg & Trop Med, Keppel St, London WC1E 7HT, England.
[Lutwama, Julius Julian] Emerging & Reemerging Infect Uganda Virus Res In, Dept Arbovirol, POB 49, Entebbe, Uganda.
RP Yavelsky, V; Lobel, L (reprint author), Ben Gurion Univ Negev, Dept Microbiol Immunol & Genet, Fac Hlth Sci, IL-84105 Beer Sheva, Israel.; Dye, JM (reprint author), US Army Med Res Inst Infect Dis, Div Virol, 1425 Porter St, Frederick, MD 21701 USA.; Lutwama, JJ (reprint author), Emerging & Reemerging Infect Uganda Virus Res In, Dept Arbovirol, POB 49, Entebbe, Uganda.
EM tautau.ariel@gmail.com; spencer.w.stonier2.ctr@mail.mil;
anderw.s.herbert.ctr@mail.mil; davidochayon@gmail.com; aikuehne@aol.com;
askiray@gmail.com; fedida.metula@gmail.com; netatali20@gmail.com;
lewis@bgu.ac.il; m.c.egesa@gmail.com; stephen.cose@lshtm.ac.uk;
jjlutwama03@yahoo.com; yavelsky@bgu.ac.il; john.m.dye1.civ@mail.mil;
leslie.lobel@gmail.com
OI Egesa, Moses/0000-0001-5136-868X; Cose, Stephen/0000-0002-5156-037X
FU Defense Threat Reduction Agency [CB3948]
FX The authors would like to acknowledge Alison Elliott and Pietro Pala for
their assistance with flow cytometry experiments at the Medical Research
Council/Uganda Virus Research Institute, Uganda Research Unit on AIDS in
Entebbe, Uganda. This work was supported by the Defense Threat Reduction
Agency (CB3948).
NR 28
TC 0
Z9 0
U1 5
U2 6
PU MDPI AG
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1999-4915
J9 VIRUSES-BASEL
JI Viruses-Basel
PD MAY
PY 2016
VL 8
IS 5
AR 133
DI 10.3390/v8050133
PG 12
WC Virology
SC Virology
GA DN9VU
UT WOS:000377429600016
ER
PT J
AU Sliozberg, YR
Chantawansri, TL
AF Sliozberg, Yelena R.
Chantawansri, Tanya L.
TI Mechanism resulting in chemical imbalance due to cellular damage
associated with mechanoporation: A molecular dynamics study
SO CHEMICAL PHYSICS LETTERS
LA English
DT Article
ID TRAUMATIC BRAIN-INJURY; PLASMA-MEMBRANE DISRUPTIONS; LIPID-BILAYERS;
PORE FORMATION; FORCE-FIELD; STRAIN-RATE; IN-VITRO; SIMULATIONS;
CALCIUM; DEPENDENCE
AB To elucidate the mechanism of ion transport through a transmembrane pore, all-atom molecular dynamics simulations were employed. A model membrane where a pore connects the intra- and extra-cellular compartment was considered. Pores with radii of 1.5 nm or less exhibited resealing over the course of 135 ns simulations, and ionic disturbance is minimal. Ion transport through a larger pore (2 nm radius) leads to a substantial change in the intra- and extra-cellular ionic concentrations. The influx of Na+ and Cl- ions down their concentration gradients is greater than the efflux of K+ leading to an osmotic influx of water. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Chantawansri, Tanya L.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Sliozberg, Yelena R.] TXC Global Inc, Aberdeen Proving Ground, MD 21005 USA.
RP Sliozberg, YR (reprint author), 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21009 USA.
EM yelena.r.sliozberg.ctr@mail.mil
FU U.S. Army Research Laboratory [W911-QX-14-C0016]
FX The authors would like to thank Drs. R.M. Elder, T. Piehler, J. Vettel,
and P. Franaszczuk for useful discussion. Calculations were performed
using the DOD Supercomputing Resource Center located at the Air Force
and Navy Laboratories. The research reported in this document was
performed in connection with contract/instrument W911-QX-14-C0016 with
the U.S. Army Research Laboratory. The views and conclusions contained
in this document are those of TKC Global Inc. and the U.S. Army Research
Laboratory. Citation of manufacturer's or trade names does not
constitute an official endorsement or approval of the use thereof. The
U.S. Government is authorized to reproduce and distribute reprints for
Government purposes notwithstanding any copyright notation hereon.
NR 41
TC 0
Z9 0
U1 5
U2 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0009-2614
EI 1873-4448
J9 CHEM PHYS LETT
JI Chem. Phys. Lett.
PD MAY
PY 2016
VL 651
BP 39
EP 45
DI 10.1016/j.cplett.2016.03.018
PG 7
WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical
SC Chemistry; Physics
GA DN6RK
UT WOS:000377203300008
ER
PT J
AU Kragh, JF
Dubick, MA
Aden, JK
McKeague, AL
Rasmussen, TE
Baer, DG
Blackbourne, LH
AF Kragh, John F., Jr.
Dubick, Michael A.
Aden, James K., III
McKeague, Anne L.
Rasmussen, Todd E.
Baer, David G.
Blackbourne, Lorne H.
TI US Military Experience From 2001 to 2010 With Extremity Fasciotomy in
War Surgery
SO MILITARY MEDICINE
LA English
DT Article
ID INJURY
AB Introduction: After trauma, compartment syndrome of the extremities is a common, disabling, and-if managed suboptimally-lethal problem. Its treatment by surgical fasciotomy continues to be useful but controversial. The purpose of this survey is to measure survival and fasciotomy in a large trauma system to characterize trends and to determine if fasciotomy is associated with improved survival. Methods: We retrospectively surveyed data from a military trauma registry for U.S. casualties from 2001 to 2010. Casualties had extremity injury or extremity fasciotomy. We associated survival and fasciotomy. Results: Of 17,166 casualties in the total study, 19% (3,313) had fasciotomy and 2.8% (481) had compartment syndrome. Annual fasciotomy rates started at 0% (2001) and rose to 26% (2010). For all casualties, the survival rate initially was high (100%) but decreased steadily until its nadir (96.4%) in 2005. Thereafter, it increased to make a V-shaped trend with reversal occurring after fielding two interventions within the trauma system specifically for casualties at risk for fasciotomy-tourniquet use and a fasciotomy education program. Conclusions: Over a decade of war, the survival rate of extremity injured casualties was associated with two trauma system interventions-tourniquet usage and a fasciotomy education program. The current example of measuring implementation of initiatives may be useful as a model for future attempted improvements in health care.
C1 [Kragh, John F., Jr.; Dubick, Michael A.; Aden, James K., III; Baer, David G.] US Army, Inst Surg Res, JBSA, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.
[McKeague, Anne L.] Z Med Corp, 4 Fairfield Blvd, Wallingford, CT 06492 USA.
[Rasmussen, Todd E.] US Army, Med Res & Mat Command, Ft Detrick, MD 21702 USA.
[Blackbourne, Lorne H.] San Antonio Mil Med Ctr, JBSA, Dept Surg, Ft Sam Houston, TX 78234 USA.
RP Kragh, JF (reprint author), US Army, Inst Surg Res, JBSA, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.
FU USAISR; Defense Health Program [201105]
FX We acknowledge the DoD Trauma Registry's staff including Susan A. West,
BSN, and Janet S. Schadee for providing data for this survey. Ralph W.
Sweet, RN, MHS, Research Nurse, USAISR, helped in data analysis and
survey management. Otilia Sanchez aided in manuscript preparation. This
project was funded with internal USAISR funds and the Defense Health
Program (Proposal 201105: Operational system management and postmarket
surveillance of hemorrhage control devices used in medical care of U.S.
servicepersons in the current war).
NR 14
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Z9 0
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAY
PY 2016
VL 181
IS 5
BP 463
EP 468
DI 10.7205/MILMED-D-15-00058
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA DN5MZ
UT WOS:000377114400013
PM 27136654
ER
PT J
AU Pugh, MJ
Jaramillo, CA
Leung, KW
Faverio, P
Fleming, N
Mortensen, E
Amuan, ME
Wang, CP
Eapen, B
Restrepo, M
Morris, MJ
AF Pugh, Mary Jo
Jaramillo, Carlos A.
Leung, Kar-wei
Faverio, Paola
Fleming, Nicholas
Mortensen, Eric
Amuan, Megan E.
Wang, Chen-Pin
Eapen, Blessen
Restrepo, Marcos
Morris, Michael J.
TI Increasing Prevalence of Chronic Lung Disease in Veterans of the Wars in
Iraq and Afghanistan
SO MILITARY MEDICINE
LA English
DT Article
ID US MILITARY PERSONNEL; OPERATION ENDURING FREEDOM; RESPIRATORY SYMPTOMS;
PARTICULATE MATTER; SOUTHWEST ASIA; DEPLOYMENT; HEALTH; SOLDIERS;
INJURY; PNEUMONIA
AB Research from the wars in Afghanistan and Iraq have focused on traumatic brain injury (TBI) and mental health conditions; however, it is becoming clear that other health concerns, such as respiratory illnesses, warrant further scientific inquiry. Early reports from theater and postdeployment health assessments suggested an association with deployment-related exposures (e.g., sand, burn pits, chemical, etc.) and new-onset respiratory symptoms. We used data from Veterans Affairs medical encounters between fiscal years 2003 and 2011 to identify trends in chronic obstructive pulmonary disease, asthma, and interstitial lung disease in veterans. We used data from Veterans Affairs and Department of Defense sources to identify sociodemographic (age, sex, race), military (e.g., service branch, multiple deployments) and clinical characteristics (TBI, smoking) of individuals with and without chronic lung diseases. Generalized estimating equations found significant increases over time for chronic obstructive pulmonary disease and asthma in both unadjusted and adjusted analyses. Trends for interstitial lung disease were significant only in adjusted analyses. Age, smoking, and TBI were also significantly associated with chronic lung diseases; however, multiple deployments were not associated. Research is needed to identify which characteristics of deployment-related exposures are linked with chronic lung disease.
C1 [Pugh, Mary Jo; Jaramillo, Carlos A.; Eapen, Blessen; Restrepo, Marcos] South Texas Vet Hlth Care Syst, 7400 Merton Minter Blvd, San Antonio, TX 78229 USA.
[Pugh, Mary Jo; Jaramillo, Carlos A.; Leung, Kar-wei; Fleming, Nicholas; Wang, Chen-Pin; Eapen, Blessen; Restrepo, Marcos] Univ Texas Hlth Sci Ctr San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA.
[Faverio, Paola] Univ Milano Bicocca, AO San Gerardo, Clin Pneumol, Dept Hlth Sci, Via Pergolesi 22, Monza, Italy.
[Mortensen, Eric] North Texas Vet Hlth Care Syst, 4500 South Lancaster Rd, Dallas, TX 75216 USA.
[Amuan, Megan E.] Edith Nourse Rogers VA Med Ctr, 200 Springs Rd, Bedford, MA 01730 USA.
[Morris, Michael J.] Uniformed Serv Univ Hlth Sci, Brooke Army Med Ctr, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
RP Pugh, MJ (reprint author), South Texas Vet Hlth Care Syst, 7400 Merton Minter Blvd, San Antonio, TX 78229 USA.; Pugh, MJ (reprint author), Univ Texas Hlth Sci Ctr San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA.
OI Pugh, Mary Jo/0000-0003-4196-7763; Mortensen, Eric/0000-0002-3880-5563
FU VA Health Services Research and Development Service [DHI 09-237]
FX Data were obtained with the assistance of the VA Office of Environmental
Epidemiology for the Operation Enduring Freedom/Operation Iraqi Freedom
Roster file. This study was funded by the VA Health Services Research
and Development Service (DHI 09-237). The content, of this article is
solely the responsibility of the authors and does not necessarily
reflect the official views of the Veterans' Health Administration or the
Department of Defense. The funding organizations had no role in the
design and conduct of die study; the collection, management, analysis,
and interpretation of the data; or the preparation, review, or approval
of the manuscript. This retrospective data study received approval
including a waiver of informed consent and Health Insurance Portability
and Accountability Act authorization by the institutional review boards
of the University of Texas Health Science Center San Antonio and the
Edith Nourse Rogers Memorial VA Hospital.
NR 27
TC 0
Z9 0
U1 1
U2 2
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAY
PY 2016
VL 181
IS 5
BP 476
EP 481
DI 10.7205/MILMED-D-15-00035
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA DN5MZ
UT WOS:000377114400015
PM 27136656
ER
PT J
AU Fulton, LV
Fabich, RA
Bhatta, J
Fletcher, B
Leininger, K
Lienesch, K
Rodriguez, TA
Coyner, JL
Johnson, AD
O'Sullivan, J
AF Fulton, Lawrence V.
Fabich, Robert A., Jr.
Bhatta, Jeevan
Fletcher, Brandon
Leininger, Kirby
Lienesch, Kevin
Rodriguez, Thais A.
Coyner, Jennifer L.
Johnson, Arthur D.
O'Sullivan, Joseph
TI Comparison of Resuscitative Protocols for Bupropion Overdose Using Lipid
Emulsion in a Swine Model
SO MILITARY MEDICINE
LA English
DT Article
ID INFUSION; BUPIVACAINE; PROLONGATION; TOXICITY
AB Aims: The aim of this study was to investigate the effects of different treatment combinations on bupropion recovery as well as time to return of spontaneous circulation. Methods:We conducted an eight group, randomized, experiment to evaluate combinations of epinephrine, vasopressin, and lipids on the restoration of cardiac function in Yorkshire pigs. After tracking the animals' baseline vitals for 10 minutes, we injected the animals with bupropion (35 mg/kg) and initiated a randomized protocol 2 minutes after cardiac arrest. Results: Results demonstrated that animal survival given treatment combinations including epinephrine were statistically superior to any other group (p < 0.001, Fishers' exact test). The odds of survival with use of epinephrine vs. other options were 22:1 (5.47, 88.43). Further, all animals receiving only lipids died. Cox survival analysis with bootstrapped parameter estimates provided evidence that the rapidity of cardiac recovery was maximized with a combination of epinephrine and lipids (p < 0.05). Conclusions: Lipids may require an additional chemical catalyst in order to be effective in cardiac recovery. Epinephrine and lipids combined shortened recovery time for surviving animals.
C1 [Fulton, Lawrence V.] Texas Tech, 703 Flint Ave, Lubbock, TX 79409 USA.
[Fulton, Lawrence V.] Texas Tech Univ Hlth Sci Syst, 703 Flint Ave, Lubbock, TX 79409 USA.
[Fabich, Robert A., Jr.; Bhatta, Jeevan; Fletcher, Brandon; Leininger, Kirby; Lienesch, Kevin; Rodriguez, Thais A.; Coyner, Jennifer L.; Johnson, Arthur D.; O'Sullivan, Joseph] US Army, Grad Program Anesthesia Nursing, Dunlap Hall,3490 Forage Ave, Ft Sam Houston, TX 78234 USA.
US Dept Def, Anim Lab, Ft Sam Houston, TX USA.
RP Fulton, LV (reprint author), Texas Tech, 703 Flint Ave, Lubbock, TX 79409 USA.; Fulton, LV (reprint author), Texas Tech Univ Hlth Sci Syst, 703 Flint Ave, Lubbock, TX 79409 USA.
FU Tri-Service Nursing Research Program
FX This research was funded under a grant from the Tri-Service Nursing
Research Program.
NR 20
TC 0
Z9 0
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAY
PY 2016
VL 181
IS 5
BP 482
EP 487
DI 10.7205/MILMED-D-15-00218
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA DN5MZ
UT WOS:000377114400016
PM 27136657
ER
PT J
AU Campagna, JDA
Bowsher, B
AF Campagna, John D. A.
Bowsher, Barbara
TI Prevalence of Body Dysmorphic Disorder and Muscle Dysmorphia Among
Entry-Level Military Personnel
SO MILITARY MEDICINE
LA English
DT Article
ID ENHANCING MEDICAL TREATMENTS; DIETARY-SUPPLEMENTS; ANOREXIA-NERVOSA;
EATING-DISORDERS; IMAGE; WEIGHTLIFTERS; COMORBIDITY; SOLDIERS; MEN;
SYMPTOMATOLOGY
AB Objective: To determine the prevalence of body dysmorphic disorder (BDD) and muscle dysmorphia (MD) in enlisted U.S. military personnel; and secondarily, to determine supplement use and relationship with BDD and MD. Methods: A survey of advanced individual training of tri-service personnel at Fort Sam Houston, Texas, was performed combining the dysmorphia concern questionnaire, the MD symptom questionnaire, a supplement questionnaire, and demographic factors. Results: Of the 1,320 service members approached, 1,150 (87.1%) completed the survey. The majority of participants were male, 62.8% (n = 722) and Army soldiers 59.0% (n = 679). The prevalence rate of BDD was 13.0% in males and 21.7% in females. The prevalence of MD was 12.7% in males and 4.2% in females. There was a strong correlation between having BDD and using supplements to get thinner (odds ratio 5.1; 95% confidence interval 3.4-7.8; p < 0.001) and MD to get more muscular (odds ratio 5.4; 95% confidence interval 3.5- 8.3; p < 0.001). Conclusions: Our study shows a higher than expected prevalence rate of BDD and MD in service members. This indicates a need for increased awareness of dysmorphias in mental health providers, primary care providers, and commanders and justifies further military specific BDD and MD research.
C1 [Campagna, John D. A.] Womack Army Med Ctr, Dept Pediat, 2817 Reilly Rd, Ft Bragg, NC 28310 USA.
[Bowsher, Barbara] San Antonio Mil Med Ctr, Dept Pediat, Adolescent Med, MCHK PE,Joint Base San Antonio, 3100 Schofield Rd,Bldg 119, Ft Sam Houston, TX 78234 USA.
RP Campagna, JDA (reprint author), Womack Army Med Ctr, Dept Pediat, 2817 Reilly Rd, Ft Bragg, NC 28310 USA.
NR 56
TC 0
Z9 0
U1 9
U2 11
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAY
PY 2016
VL 181
IS 5
BP 494
EP 501
DI 10.7205/MILMED-D-15-00118
PG 8
WC Medicine, General & Internal
SC General & Internal Medicine
GA DN5MZ
UT WOS:000377114400018
PM 27136659
ER
PT J
AU Dozier, J
Bair, EH
Davis, RE
AF Dozier, Jeff
Bair, Edward H.
Davis, Robert E.
TI Estimating the spatial distribution of snow water equivalent in the
world's mountains
SO WILEY INTERDISCIPLINARY REVIEWS-WATER
LA English
DT Review
ID SIR-C/X-SAR; COLORADO RIVER-BASIN; PASSIVE MICROWAVE; ALBEDO PRODUCT;
UNITED-STATES; COVER; DEPTH; MODEL; MODIS; PRECIPITATION
AB Estimating the spatial distribution of snow water equivalent (SWE) in mountainous terrain is currently the most important unsolved problem in snow hydrology. Several methods can estimate the amount of snow throughout a mountain range: (1) Spatial interpolation from surface sensors constrained by remotely sensed snow extent provides a consistent answer, with uncertainty related to extrapolation to unrepresented locations. (2) The remotely sensed date of disappearance of snow is combined with a melt calculation to reconstruct the SWE back to the last significant snowfall. (3) Passive microwave sensors offer real-time global SWE estimates but suffer from several problems like subpixel variability in the mountains. (4) A numerical model combined with assimilated surface observations produces SWE at 1-km resolution at continental scales, but depends heavily on a surface network. (5) New methods continue to be explored, for example, airborne LiDAR altimetry provides direct measurements of snow depth, which are combined with modelled snow density to estimate SWE. While the problem is aggressively addressed, the right answer remains elusive. Good characterization of the snow is necessary to make informed choices about water resources and adaptation to climate change and variability. (C) 2016 Wiley Periodicals, Inc.
C1 [Dozier, Jeff] Univ Calif Santa Barbara, Bren Sch Environm Sci & Management, Santa Barbara, CA 93106 USA.
[Bair, Edward H.] Univ Calif Santa Barbara, Earth Res Inst, Santa Barbara, CA 93106 USA.
[Davis, Robert E.] US Army, Cold Reg Res & Engn Lab, Hanover, NH USA.
RP Dozier, J (reprint author), Univ Calif Santa Barbara, Bren Sch Environm Sci & Management, Santa Barbara, CA 93106 USA.
EM dozier@ucsb.edu
OI Dozier, Jeff/0000-0001-8542-431X
NR 82
TC 2
Z9 2
U1 6
U2 11
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2049-1948
J9 WIRES-WATER
JI Wiley Interdiscip. Rev.-Water
PD MAY-JUN
PY 2016
VL 3
IS 3
BP 461
EP 474
DI 10.1002/wat2.1140
PG 14
WC Water Resources
SC Water Resources
GA DN5QT
UT WOS:000377125900009
ER
PT J
AU Fan, XL
Zhu, YJ
Luo, C
Suo, LM
Lin, Y
Gao, T
Xu, K
Wang, CS
AF Fan, Xiulin
Zhu, Yujie
Luo, Chao
Suo, Liumin
Lin, Yan
Gao, Tao
Xu, Kang
Wang, Chunsheng
TI Pomegranate-Structured Conversion-Reaction Cathode with a Built-in Li
Source for High-Energy Li-Ion Batteries
SO ACS NANO
LA English
DT Article
DE conversion-reaction cathode materials; prelithiation; transition metal
fluorides; FeF3
ID FLUORIDE THIN-FILMS; IRON FLUORIDE; ELECTRODE MATERIALS; LITHIUM
BATTERIES; METAL FLUORIDES; REACTION-MECHANISMS; ANODE MATERIAL; CARBON
MATRIX; NI-C; NANOCOMPOSITE
AB Transition metal fluorides (such as FeF3 or CoF2) promise significantly higher theoretical capacities (>571 mAh g(-1)) than the cathode materials currently used in Li-ion batteries. However, their practical application faces major challenges that include poor electrochemical reversibility induced by the repeated bondbreaking and formation and the accompanied volume changes and the difficulty of building an internal Li source within the material so that a full Li-ion cell could be assembled at a discharged state without inducing further technical risk and cost issues. In this work, we effectively addressed these challenges by designing and synthesizing, via an aerosolspray pyrolysis technique, a pomegranate structured nanocomposite FeM/LiF/C (M = Co, Ni), in which 2-3 mn carbon-coated FeM nanoparticles (similar to 10 nm in diameter) and LiF nanoparticles (similar to 20 nm) are uniformly embedded in a porous carbon sphere matrix (100-1000 nm). This uniquely architectured nanocomposite was made possible by the extremely short pyrolysis time (similar to 1 s) and carbon coating in a high-temperature furnace, which prevented the overgrowth of FeM and LiF in the primordial droplet that serves as the carbon source. The presence of Ni or Co in FeM/LiF/C effectively suppresses the formation of Fe3C and further reduces the metallic particle size. The pomegranate architecture ensures the intimate contact among FeM, LiF, and C, thus significantly enhancing the conversion-reaction kinetics, while the nanopores inside the pomegranate-like carbon matrix, left by solvent evaporation during the pyrolysis, effectively accommodate the volume change of FeM/LiF during charge/discharge. Thus, the FeM/LiF/C nanocomposite shows a high specific capacity of >300 mAh g(-1) for more than 100 charge/discharge cycles, which is one of the best performances among all of the prelithiated metal fluoride cathodes ever reported. The pomegranate-structured FeM/LiF/C with its built-in Li source provides an inspiration to the practical application of conversion-reaction-type chemistries as next-generation cathode materials for high-energy density Li-ion batteries.
C1 [Fan, Xiulin; Zhu, Yujie; Luo, Chao; Suo, Liumin; Lin, Yan; Gao, Tao; Wang, Chunsheng] Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA.
[Xu, Kang] US Army Res Lab, Electrochem Branch, Power & Energy Div, Sensor & Electron Devices Directorate, Adelphi, MD 20783 USA.
RP Wang, CS (reprint author), Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA.; Xu, K (reprint author), US Army Res Lab, Electrochem Branch, Power & Energy Div, Sensor & Electron Devices Directorate, Adelphi, MD 20783 USA.
EM conrad.k.xu.civ@mail.mil; cswang@umd.edu
RI Wang, Chunsheng/H-5767-2011
OI Wang, Chunsheng/0000-0002-8626-6381
FU Army Research Lab [W911NF1420031]; Maryland NanoCenter and its NispLab
FX This work was supported by the Army Research Lab under Award Number
W911NF1420031. The authors gratefully acknowledge the support of the
Maryland NanoCenter and its NispLab. The highly pure fluorinated
solvents were provided by Drs. Ron Hendershot and Joe Sundstrom of
Daikin America.
NR 62
TC 3
Z9 3
U1 30
U2 85
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1936-0851
EI 1936-086X
J9 ACS NANO
JI ACS Nano
PD MAY
PY 2016
VL 10
IS 5
BP 5567
EP 5577
DI 10.1021/acsnano.6b02309
PG 11
WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
Nanotechnology; Materials Science, Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA DN1KQ
UT WOS:000376825100076
PM 27163232
ER
PT J
AU Wu, J
Jiang, Q
Chen, SM
Tang, MC
Mazur, YI
Maidaniuk, Y
Benamara, M
Semtsiv, MP
Masselink, WT
Sablon, KA
Salamo, GJ
Liu, HY
AF Wu, Jiang
Jiang, Qi
Chen, Siming
Tang, Mingchu
Mazur, Yuriy I.
Maidaniuk, Yurii
Benamara, Mourad
Semtsiv, Mykhaylo P.
Masselink, W. Ted
Sablon, Kimberly A.
Salamo, Gregory J.
Liu, Huiyun
TI Monolithically Integrated InAs/GaAs Quantum Dot Mid-Infrared
Photodetectors on Silicon Substrates
SO ACS PHOTONICS
LA English
DT Article
DE quantum dots; infrared photodetectors; silicon; molecular beam epitaxy
ID INFRARED PHOTODETECTORS; ENERGY RELAXATION; GE SUBSTRATE; LASERS;
EPITAXY; HGCDTE
AB High-performance, multispectral, and large-format infrared focal plane arrays are the long-demanded third-generation infrared technique for hyperspectral imaging, infrared spectroscopy, and target identification. A promising solution is to monolithically integrate infrared photodetectors on a silicon platform, which offers not only low-cost but high-resolution focal plane arrays by taking advantage of the well-established Si-based readout integrated circuits. Here, we report the first InAs/GaAs quantum dot (QD) infrared photodetectors monolithically integrated on silicon substrates by molecular beam epitaxy. The III-V photodetectors are directly grown on silicon substrates by using a GaAs buffer, which reduces the threading dislocation density to similar to 10(6) cm(-2). The high-quality QDs grown on Si substrates have led to long photocarrier relaxation time and low dark current density. Mid-infrared photodetection up to similar to 8 mu m is also achieved at 80 K. This work demonstrates that photodetectors can directly be integrated with silicon readout circuitry for realizing large-format focal plane arrays as well as mid-infrared photonics in silicon.
C1 [Wu, Jiang; Jiang, Qi; Chen, Siming; Tang, Mingchu; Liu, Huiyun] UCL, Dept Elect & Elect Engn, London WC1E 7JE, England.
[Mazur, Yuriy I.; Maidaniuk, Yurii; Benamara, Mourad; Salamo, Gregory J.] Univ Arkansas, Inst Nanosci & Engn, Fayetteville, AR 72701 USA.
[Semtsiv, Mykhaylo P.; Masselink, W. Ted] Humboldt Univ, Dept Phys, Newtonstr 15, D-12489 Berlin, Germany.
[Sablon, Kimberly A.] US Army, Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
RP Wu, J (reprint author), UCL, Dept Elect & Elect Engn, London WC1E 7JE, England.
EM jiang.wu@ucl.ac.uk
RI Liu, Huiyun/H-5439-2011
FU National Science Foundation of the U.S. (EPSCoR) [OIA-1457888]; Royal
Society
FX The authors acknowledge the support of the National Science Foundation
of the U.S. (EPSCoR Grant No. OIA-1457888). H.L. would like to thank The
Royal Society for funding his University Research Fellowship.
NR 32
TC 0
Z9 0
U1 8
U2 27
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 2330-4022
J9 ACS PHOTONICS
JI ACS Photonics
PD MAY
PY 2016
VL 3
IS 5
BP 749
EP 753
DI 10.1021/acsphotonics.6b00076
PG 5
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary;
Optics; Physics, Applied; Physics, Condensed Matter
SC Science & Technology - Other Topics; Materials Science; Optics; Physics
GA DM4RF
UT WOS:000376333700004
ER
PT J
AU Brouillette, C
Smith, W
Shende, C
Gladding, Z
Farquharson, S
Morris, RE
Cramer, JA
Schmitigal, J
AF Brouillette, Carl
Smith, Wayne
Shende, Chetan
Gladding, Zack
Farquharson, Stuart
Morris, Robert E.
Cramer, Jeffrey A.
Schmitigal, Joel
TI Analysis of Twenty-Two Performance Properties of Diesel, Gasoline, and
Jet Fuels Using a Field-Portable Near-Infrared (NIR) Analyzer
SO APPLIED SPECTROSCOPY
LA English
DT Article
DE Fuel analysis; fuel properties; fuel analyzer; near-infrared
spectroscopy; NIR
ID PARTIAL LEAST-SQUARES; FT-IR; RAMAN-SPECTROSCOPY; PETROLEUM FUELS;
OCTANE NUMBERS
AB The change in custody of fuel shipments at depots, pipelines, and ports could benefit from an analyzer that could rapidly verify that properties are within specifications. To meet this need, the design requirements for a fuel analyzer based on near-infrared (NIR) spectroscopy, such as spectral region and resolution, were examined. It was found that the 1000 to 1600nm region, containing the second CH overtone and combination vibrational modes of hydrocarbons, provided the best near-infrared to fuel property correlations when path length was taken into account, whereas 4cm(-1) resolution provided only a modest improvement compared to 16cm(-1) resolution when four or more latent variables were used. Based on these results, a field-portable near-infrared fuel analyzer was built that employed an incandescent light source, sample compartment optics to hold 2mL glass sample vials with approximate to 1cm path length, a transmission grating, and a 256 channel InGaAs detector that measured the above stated wavelength range with 5-6nm (approximate to 32cm(-1)) resolution. The analyzer produced high signal-to-noise ratio (SNR) spectra of samples in 5s. Twenty-two property correlation models were developed for diesel, gasoline, and jet fuels with root mean squared error of correlation - cross-validated values that compared favorably to corresponding ASTM reproducibility values. The standard deviations of predicted properties for repeat measurements at 4, 24, and 38? were often better than ASTM documented repeatability values. The analyzer and diesel property models were tested by measuring seven diesel samples at a local ASTM certification laboratory. The standard deviations between the analyzer determined values and the ASTM measured values for these samples were generally better than the model root mean squared error of correlationcross-validated values for each property.
C1 [Brouillette, Carl; Smith, Wayne; Shende, Chetan; Gladding, Zack; Farquharson, Stuart] Real Time Analyzers Inc, 362 Ind Pk Rd,8, Middletown, CT USA.
[Morris, Robert E.; Cramer, Jeffrey A.] Naval Res Lab, Washington, DC 20375 USA.
[Schmitigal, Joel] US Army, TARDEC, Warren, MI USA.
RP Farquharson, S (reprint author), Real Time Analyzers Inc, 362 Ind Pk Rd,8, Middletown, CT USA.
EM stu@rta.biz
FU US Army SBIR program [W56HZV-13-C-0296]; US Army; US Navy and Defense
Logistics Agency [W56HZV-14-C-0106]
FX Real-Time Analyzers, Inc. is grateful for the support provided by the US
Army SBIR program (grant number W56HZV-13-C-0296) and the US Army in
conjunction with the US Navy and Defense Logistics Agency (grant number
W56HZV-14-C-0106) in developing the portable fuel analyzer.
NR 16
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U1 7
U2 7
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-7028
EI 1943-3530
J9 APPL SPECTROSC
JI Appl. Spectrosc.
PD MAY
PY 2016
VL 70
IS 5
SI SI
BP 746
EP 755
DI 10.1177/0003702816638279
PG 10
WC Instruments & Instrumentation; Spectroscopy
SC Instruments & Instrumentation; Spectroscopy
GA DM3XU
UT WOS:000376280800003
PM 27006025
ER
PT J
AU Sugiharto, VA
Murphy, JR
Turell, MJ
Olsen, CH
Stewart, VA
Colacicco-Mayhugh, MG
Grieco, JP
Achee, NL
AF Sugiharto, Victor A.
Murphy, Jittawadee R.
Turell, Michael J.
Olsen, Cara H.
Stewart, V. Ann
Colacicco-Mayhugh, Michelle G.
Grieco, John P.
Achee, Nicole L.
TI Dengue Virus-1 Infection Did Not Alter the Behavioral Response of Aedes
aegypti (Diptera: Culicidae) to DEET
SO JOURNAL OF MEDICAL ENTOMOLOGY
LA English
DT Article
DE Aedes aegypti; DEET; behavior; dengue
ID INSECT REPELLENT DEET; LA-CROSSE VIRUS; FEEDING-BEHAVIOR; SINDBIS VIRUS;
MOSQUITOS; ALBOPICTUS; SYSTEM; REPLICATION; TRISERIATUS; RECEPTORS
AB No licensed vaccine or antiviral drug against dengue virus (DENV) is available; therefore, most of the effort to prevent this disease is focused on reducing vector-host interactions. One of the most widely accepted methods of blocking vector-human contact is to use insect repellents to interfere with mosquito host-seeking behavior. Some arboviruses can replicate in the nervous system of the vector, raising the concern that arboviral infection may alter the insect behavioral response toward chemical stimuli. Three different Aedes aegypti (L.) mosquito cohorts: DENV-1-injected, diluent-injected, and uninjected were subjected to behavioral tests using a high-throughput screening system with 2.5% DEET and 0.14% DEET on 1, 4, 7, 10, 14, and 17 d postinjection. All test cohorts exhibited significant contact irritant or escape responses when they were exposed to 2.5% or 0.14% DEET. However, we found no biologically relevant irritancy response change in DENV-1-infected Ae. aegypti mosquitoes when they were exposed to DEET. Further studies evaluating the effects of other arboviral infections on insect repellents activity are necessary in order to provide better recommendation on the prevention of vector-borne disease transmission.
C1 [Sugiharto, Victor A.; Murphy, Jittawadee R.; Olsen, Cara H.; Stewart, V. Ann; Grieco, John P.; Achee, Nicole L.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biostat, Bethesda, MD 20814 USA.
[Turell, Michael J.] US Army, Med Res Inst Infect Dis, Div Virol, Dept Vector Assessment, Ft Detrick, MD 21702 USA.
[Colacicco-Mayhugh, Michelle G.; Grieco, John P.] Med Countermeasure Syst, Ft Detrick, MD 21702 USA.
[Achee, Nicole L.] Univ Notre Dame, Eck Inst Global Hlth, Dept Biol Sci, Galvin Life Sci Ctr 239, Notre Dame, IN 46556 USA.
RP Sugiharto, VA (reprint author), Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biostat, Bethesda, MD 20814 USA.
EM victor.sugiharto@usuhs.edu; jittawadee.murphy@usuhs.edu;
mturell@erols.com; cara.olsen@usuhs.edu; ann.stewart@usuhs.edu;
michelle.g.colaciccomayhugh.mil@mail.mil; jgrieco@nd.edu; nachee@nd.edu
FU Uniformed Services University of the Health Sciences [R08701,
T0872211113]
FX We would like to thank our colleagues at the Entomology and the Viral
Diseases Branches at the Walter Reed Army Institute of Research (WRAIR),
Silver Spring, MD, especially E. Rowton, J. Richardson, S. Davidson, and
T. Rowland for the use of the WRAIR containment facility, providing Ae.
aegypti mosquito populations, and the DENV-1 stock. We would also like
to thank K. Chauhan of USDA for providing neat-grade DEET and W. Ching
and C. Chao of Naval Medical Research Center for their generosity in
lending their Applied Biosystem 7500 Fast RealTime PCR Machine. This
study was supported by the Uniformed Services University of the Health
Sciences grants R08701 and T0872211113.
NR 36
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PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-2585
EI 1938-2928
J9 J MED ENTOMOL
JI J. Med. Entomol.
PD MAY
PY 2016
VL 53
IS 3
BP 687
EP 691
DI 10.1093/jme/tjw030
PG 5
WC Entomology; Veterinary Sciences
SC Entomology; Veterinary Sciences
GA DM6II
UT WOS:000376454800029
PM 27026163
ER
PT J
AU Obenauer, PJ
Rueda, LM
El-Hossary, SS
Watany, N
Stoops, CA
Fakoli, LS
Bolay, FK
Diclaro, JW
AF Obenauer, P. J.
Rueda, L. M.
El-Hossary, S. S.
Watany, N.
Stoops, C. A.
Fakoli, L. S.
Bolay, F. K.
Diclaro, J. W., II
TI New Records and Updated Checklist of Phlebotomine Sand Flies (Diptera:
Psychodidae) From Liberia
SO JOURNAL OF MEDICAL ENTOMOLOGY
LA English
DT Article
DE Leishmaniasis; Phlebotomus; Sergentomyia; West Africa
ID SANDFLIES; LEISHMANIASIS; BIOLOGY; COMPLEX; GHANA
AB Phlebotomine sand flies from three counties in Liberia were collected from January 2011 to July 2013. In total, 3,118 sand flies were collected: 18 species were identified, 13 of which represented new records for Liberia. An updated taxonomic checklist is provided with a brief note on sand fly biology, and the disease vector potential for species is discussed.
C1 [Obenauer, P. J.] US Navy, 1600 Clifton Rd,649,Bldg 23,Off 9-117, Atlanta, GA 30329 USA.
[Obenauer, P. J.] Ctr Dis Control & Prevent, Marine Corps Publ Hlth Ctr Det, 1600 Clifton Rd,649,Bldg 23,Off 9-117, Atlanta, GA 30329 USA.
[Rueda, L. M.; El-Hossary, S. S.; Watany, N.] Walter Reed Army Inst Res, Walter Reed Biosystemat Unit, Entomol Branch, Silver Spring, MD USA.
[Rueda, L. M.; El-Hossary, S. S.; Watany, N.] Adjacent Abbassa Fever Hosp, Imtidad Ramses St, Abbassa 11517, Egypt.
[Diclaro, J. W., II] US Navy, Med Res Unit 3, Cairo, Egypt.
[Stoops, C. A.] US Navy, Med Res Unit Lima Peru 6, 3230 Lima Pl, Washington, DC 20521 USA.
[Fakoli, L. S.; Bolay, F. K.] Liberian Inst Biomed Res, POB 31, Monrovia, Liberia.
RP Obenauer, PJ (reprint author), US Navy, 1600 Clifton Rd,649,Bldg 23,Off 9-117, Atlanta, GA 30329 USA.; Obenauer, PJ (reprint author), Ctr Dis Control & Prevent, Marine Corps Publ Hlth Ctr Det, 1600 Clifton Rd,649,Bldg 23,Off 9-117, Atlanta, GA 30329 USA.
EM Yry3@cdc.gov; ruedapol@si.edu; shabaanelhossary57@yahoo.com;
Noha.Watany.eg@med.navy.mil; craig.a.stoops.mil@mail.mil;
lawfako2008@yahoo.com; bolayf@lr.afro.who.int; DiclaroJW@state.gov
FU Department of Defense's Global Emerging Infections System (GEIS)
[C0436-11-N3, C0549-12-N3]
FX We thank Maria Badra for her assistance with logistical support of all
personnel and materials pertaining to this study, and El-Shaimaa Nour
El-Din, Rania Kaldas, Emad Fawaz, and Mahmoud Abdel-Dayem for their help
in processing, identifying, and testing sand fly specimens. We thank the
U.S. Navy Entomology Center of Excellence (NECE) staff for their
assistance with collecting sand flies. We are grateful to the support
staff of the Liberian Institute for Biomedical Research (LIBR),
Monrovia, Liberia, for assisting and executing this study. A special
thanks to Graham White and Seth Irish for providing a critical review of
this manuscript. The views expressed in this article are those of the
authors and do not necessarily reflect the official policy or position
of the Department of the Navy, the Department of the Army, and the
Department of Defense, nor the U.S. Government. This work was funded by
the Department of Defense's Global Emerging Infections System (GEIS)
unit work numbers C0436-11-N3 and C0549-12-N3. This work was prepared as
part of our official duties. Title 17 U.S.C. 105 provides that
"Copyright protection under this title is not available for any work of
the United States Government." Title 17 U.S.C. 101 defines a U.S.
Government work as a work prepared by a military service member or
employee of the U.S. Government as part of that person's official
duties. Furthermore, this research was performed under a Memorandum of
Understanding between the Walter Reed Army Institute of Research and the
Smithsonian Institution, with institutional support provided by both
organizations.
NR 22
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U1 0
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PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-2585
EI 1938-2928
J9 J MED ENTOMOL
JI J. Med. Entomol.
PD MAY
PY 2016
VL 53
IS 3
BP 717
EP 720
DI 10.1093/jme/tjv255
PG 4
WC Entomology; Veterinary Sciences
SC Entomology; Veterinary Sciences
GA DM6II
UT WOS:000376454800036
PM 26810730
ER
PT J
AU Davis, FC
Neta, M
Kim, MJ
Moran, JM
Whalen, PJ
AF Davis, F. Caroline
Neta, Maital
Kim, M. Justin
Moran, Joseph M.
Whalen, Paul J.
TI Interpreting ambiguous social cues in unpredictable contexts
SO SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
LA English
DT Article
DE amygdala; emotion; facial expression; Unpredictability
ID HUMAN AMYGDALA RESPONSES; FACIAL EXPRESSIONS; TEMPORAL UNPREDICTABILITY;
INDIVIDUAL-DIFFERENCES; SURPRISED FACES; STATE ANXIETY; FEAR; FMRI;
ACTIVATION; PICTURES
AB Unpredictable environments can be anxiety-provoking and elicit exaggerated emotional responses to aversive stimuli. Even neutral stimuli, when presented in an unpredictable fashion, prime anxiety-like behavior and elicit heightened amygdala activity. The amygdala plays a key role in initiating responses to biologically relevant information, such as facial expressions of emotion. While some expressions clearly signal negative (anger) or positive (happy) events, other expressions (e.g. surprise) are more ambiguous in that they can predict either valence, depending on the context. Here, we sought to determine whether unpredictable presentations of ambiguous facial expressions would bias participants to interpret them more negatively. We used functional magnetic resonance imaging and facial electromyography (EMG) to characterize responses to predictable vs unpredictable presentations of surprised faces. We observed moderate but sustained increases in amygdala reactivity to predictable presentations of surprised faces, and relatively increased amygdala responses to unpredictable faces that then habituated, similar to previously observed responses to clearly negative (e.g. fearful) faces. We also observed decreased corrugator EMG responses to predictable surprised face presentations, similar to happy faces, and increased responses to unpredictable surprised face presentations, similar to angry faces. Taken together, these data suggest that unpredictability biases people to interpret ambiguous social cues negatively.
C1 [Davis, F. Caroline; Moran, Joseph M.] US Army, NSRDEC, Cognit Sci, Natick, MA USA.
[Neta, Maital] Univ Nebraska, Ctr Brain Biol & Behav, Lincoln, NE USA.
[Kim, M. Justin; Whalen, Paul J.] Dartmouth Coll, Dept Psychol & Brain Sci, Hanover, NH 03755 USA.
[Moran, Joseph M.] Harvard Univ, Dept Psychol, 33 Kirkland St, Cambridge, MA 02138 USA.
RP Davis, FC (reprint author), NSRDEC, 10 Kansas St, Natick, MA 01760 USA.
EM f.c.davis4.civ@mail.mil
FU National Institutes of Mental Health of the National Institutes of
Health [P50MH069315, R01MH080716, F31MH090672]
FX This research was supported by the National Institutes of Mental Health
of the National Institutes of Health under award numbers P50MH069315,
R01MH080716 and F31MH090672. The content of the reported research is
solely the responsibility of the authors and does not necessarily
represent the official views of the National Institutes of Health.
NR 52
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U2 11
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1749-5016
EI 1749-5024
J9 SOC COGN AFFECT NEUR
JI Soc. Cogn. Affect. Neurosci.
PD MAY
PY 2016
VL 11
IS 5
BP 775
EP 782
DI 10.1093/scan/nsw003
PG 8
WC Neurosciences; Psychology; Psychology, Experimental
SC Neurosciences & Neurology; Psychology
GA DM9AH
UT WOS:000376655100009
PM 26926605
ER
PT J
AU Brown, CJ
Ward, J
Mirecki, J
AF Brown, Christopher J.
Ward, James
Mirecki, June
TI A Revised Brackish Water Aquifer Storage and Recovery (ASR) Site
Selection Index for Water Resources Management
SO WATER RESOURCES MANAGEMENT
LA English
DT Article
DE ASR; Performance factors; Recovery efficiency; Brackish water; Site
selection; Dimensionless numbers; Upper Floridan Aquifer
ID SALINE AQUIFERS; FRESH-WATER; OPERATION; QUALITY
AB The performance of a brackish water aquifer storage and recovery (ASR) system is controlled by complex interactions among many variables. Some of these variables can be combined into dimensionless parameters to investigate the physical behavior and performance of an ASR well. Previous research has demonstrated that six dimensionless numbers are most useful for prediction of general performance of planned ASR projects. This paper first summarizes the critical literature and outlines the six dimensionless parameters and their various variable components. Then the new index is developed using the three best parameters. The three dimensionless parameters (RI, R-ASR and D) are normalized, scaled from 0 to 1, and combined through averaging to create a revised "Brackish Water ASR Site Selection Index" or I-ASR. The newly revised index builds upon previous work but also adds new variables important to site selection planning. In order to provide further validity to the index, it is validated against 29 ASR projects in Florida, USA. Finally, the use of the index is demonstrated for the Upper Floridan Aquifer in South Florida, USA. The demonstrated use of the new index illustrates how it can be useful for future ASR planning.
C1 [Brown, Christopher J.] Univ N Florida, Sch Engn, Bldg 50,Room 2100, Jacksonville, FL 32224 USA.
[Ward, James] Univ S Australia, SA Water Ctr Water Management & Reuse, GPO Box 2471, Adelaide, SA 5001, Australia.
[Mirecki, June] US Army, Corps Engineers, Geotech Branch, 701 San Marco Blvd, Jacksonville, FL 32207 USA.
RP Brown, CJ (reprint author), Univ N Florida, Sch Engn, Bldg 50,Room 2100, Jacksonville, FL 32224 USA.
EM christopher.j.brown@unf.edu; James.Ward@unisa.edu.au;
June.E.Mirecki@usace.army.mil
NR 47
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U1 4
U2 5
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0920-4741
EI 1573-1650
J9 WATER RESOUR MANAG
JI Water Resour. Manag.
PD MAY
PY 2016
VL 30
IS 7
BP 2465
EP 2481
DI 10.1007/s11269-016-1297-7
PG 17
WC Engineering, Civil; Water Resources
SC Engineering; Water Resources
GA DK0HO
UT WOS:000374593700022
ER
PT J
AU Goetz, AE
Pascual, LMM
Dunford, DG
Ogawa, KA
Knorr, DB
Boydston, AJ
AF Goetz, Adam E.
Pascual, Laura M. M.
Dunford, Damian G.
Ogawa, Kelli A.
Knorr, Daniel B., Jr.
Boydston, Andrew J.
TI Expanded Functionality of Polymers Prepared Using Metal-Free
Ring-Opening Metathesis Polymerization
SO ACS MACRO LETTERS
LA English
DT Article
ID LIVING RADICAL POLYMERIZATION; LIGHT PHOTOREDOX CATALYSIS;
VISIBLE-LIGHT; ELECTRON-TRANSFER; ENOL ETHERS; TETRAHYDROFURAN; POLARITY
AB Photoredox-mediated metal-free ring-opening metathesis polymerization (MF-ROMP) is an alternative to traditional metal-mediated ROMP that avoids the use of transition metal initiators while also enabling temporal control over the polymerization. Herein, we explore the effect of various additives on the success of the polymerization in order to optimize reaction protocols and identify new functionalized monomers that can be utilized in MF-ROMP. The use of protected alcohol monomers allows for homo- and copolymers to be prepared that contain functionality beyond simple alkyl groups. Several other functional groups are also tolerated to varying degrees and offer insight into future directions for expansion of monomer scope.
C1 [Goetz, Adam E.; Pascual, Laura M. M.; Dunford, Damian G.; Ogawa, Kelli A.; Boydston, Andrew J.] Univ Washington, Dept Chem, Seattle, WA 98195 USA.
[Knorr, Daniel B., Jr.] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
RP Boydston, AJ (reprint author), Univ Washington, Dept Chem, Seattle, WA 98195 USA.
EM ajb1515@uw.edu
FU Army Research Office [W911NF-15-1-0139]; Washington Research Foundation;
Department of Defense; Army Research Office
FX We gratefully acknowledge financial support from the Army Research
Office (Grant No. W911NF-15-1-0139) and the Washington Research
Foundation. LMMP thanks the Department of Defense and Army Research
Office for a National Defense Science and Engineering Graduate
Fellowship.
NR 29
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U1 9
U2 22
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 2161-1653
J9 ACS MACRO LETT
JI ACS Macro Lett.
PD MAY
PY 2016
VL 5
IS 5
BP 579
EP 582
DI 10.1021/acsmacrolett.6b00131
PG 4
WC Polymer Science
SC Polymer Science
GA DM3DA
UT WOS:000376225800006
ER
PT J
AU Horton, JM
Wiles, GC
Lawson, DE
Appleton, SN
Wilch, J
Wiesenberg, N
AF Horton, Jennifer M.
Wiles, Gregory C.
Lawson, Daniel E.
Appleton, Sarah N.
Wilch, Joseph
Wiesenberg, Nicholas
TI Tree ring-dated glacial history for the first millennium CE, Casement
Glacier and Adams Inlet, Glacier Bay, Alaska, USA
SO ARCTIC ANTARCTIC AND ALPINE RESEARCH
LA English
DT Article
ID SOUTHEAST ALASKA; TEMPERATURE VARIABILITY; NATIONAL-PARK; MUIR INLET;
FLUCTUATIONS; AGE; ADVANCE; AD; PRESERVE; UPLIFT
AB Calendar dating of tree-ring series from 16 logs sampled near the margin of Casement Glacier combined with tree-ring dates on 36 detrital logs from Adams Inlet, Glacier Bay National Park and Preserve, Alaska, show killing of trees by ice and lake sediments from the mid-sixth through mid-seventh centuries C.E. The dates from the land-terminating Casement Glacier show ice advance into a forest between 560 and 570 C.E. within a few kilometers of the 2011 retreating margin.Advance of the tidewater glacier in Muir Inlet blocked offAdams Inlet forming Lake Adams between 540 and 640 C.E. This glacier and lake history for Glacier Bay is consistent with other land-terminating ice expansions across the Gulf of Alaska that similarly show advance centered on 600 C.E., as well as other proxy records from lakes all suggesting cooling during this interval. The cooling closely follows a series of eruptions in the mid to late sixth century, which may have contributed to the cooling. Radiocarbon ages in Adams Inlet suggest that Lake Adams persisted through 880 cal. yr C.E. and drained by 1170 cal. yr C.E. Ice retreat and this lake drainage are broadly coincident with Medieval warming recognized along the Gulf of Alaska in dendroclimatic reconstructions. Shortly after this retreat, Little Ice Age readvance occurred with Casement Glacier coalescing with glaciers in Adams Inlet and the West Arm, subsequently filling all of Glacier Bay to its Holocene maximum by 1750 C.E.
C1 [Horton, Jennifer M.; Wiles, Gregory C.; Appleton, Sarah N.; Wilch, Joseph; Wiesenberg, Nicholas] Coll Wooster, Dept Geol, 1189 Beall Ave, Wooster, OH 44691 USA.
[Lawson, Daniel E.] CRREL, 72 Lyme Rd, Hanover, NH 03755 USA.
[Lawson, Daniel E.] Dartmouth Coll, 72 Lyme Rd, Hanover, NH 03755 USA.
RP Wiles, GC (reprint author), Coll Wooster, Dept Geol, 1189 Beall Ave, Wooster, OH 44691 USA.
EM gwiles@wooster.edu
FU National Science Foundation [ATM-0902799, AGS-1502186]
FX This work was supported by the National Science Foundation under grants
ATM-0902799, ATM-0902799, and AGS-1502186. We appreciate the logistical
support provided by the National Park Service at Glacier Bay National
Park and Preserve and its ongoing collaboration in curating the Glacier
Bay collection of interstadial wood. We would also like to thank three
anonymous reviewers for their careful critique and advice.
NR 40
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U1 5
U2 5
PU INST ARCTIC ALPINE RES
PI BOULDER
PA UNIV COLORADO, BOULDER, CO 80309 USA
SN 1523-0430
EI 1938-4246
J9 ARCT ANTARCT ALP RES
JI Arct. Antarct. Alp. Res.
PD MAY
PY 2016
VL 48
IS 2
BP 253
EP 261
DI 10.1657/AAAR0015-038
PG 9
WC Environmental Sciences; Geography, Physical
SC Environmental Sciences & Ecology; Physical Geography
GA DM3DJ
UT WOS:000376226700003
ER
PT J
AU Tati, S
Rager, S
Ko, BJ
Cao, GH
Swami, A
La Porta, T
AF Tati, Srikar
Rager, Scott
Ko, Bong Jun
Cao, Guohong
Swami, Ananthram
La Porta, Thomas
TI netCSI: A Generic Fault Diagnosis Algorithm for Large-Scale Failures in
Computer Networks
SO IEEE TRANSACTIONS ON DEPENDABLE AND SECURE COMPUTING
LA English
DT Article
DE Fault diagnosis; large-scale network failures; incomplete information;
clustered failures
ID TOMOGRAPHY
AB We present a framework and a set of algorithms for determining faults in networks when large scale outages occur. The design principles of our algorithm, netCSI, are motivated by the fact that failures are geographically clustered in such cases. We address the challenge of determining faults with incomplete symptom information due to a limited number of reporting nodes. netCSI consists of two parts: a hypotheses generation algorithm, and a ranking algorithm. When constructing the hypothesis list of potential causes, we make novel use of positive and negative symptoms to improve the precision of the results. In addition, we propose pruning and thresholding along with a dynamic threshold value selector, to reduce the complexity of our algorithm. The ranking algorithm is based on conditional failure probability models that account for the geographic correlation of the network objects in clustered failures. We evaluate the performance of netCSI for networks with both random and realistic topologies. We compare the performance of netCSI with an existing fault diagnosis algorithm, MAX-COVERAGE, and demonstrate an average gain of 128 percent in accuracy for realistic topologies.
C1 [Tati, Srikar; Rager, Scott; Cao, Guohong; La Porta, Thomas] Penn State Univ, University Pk, PA 16802 USA.
[Ko, Bong Jun] IBM TJ Watson Res Ctr, Cambridge, MA USA.
[Swami, Ananthram] Army Res Lab, Adelphi, MD 20783 USA.
RP Tati, S; Rager, S; Cao, GH; La Porta, T (reprint author), Penn State Univ, University Pk, PA 16802 USA.; Ko, BJ (reprint author), IBM TJ Watson Res Ctr, Cambridge, MA USA.; Swami, A (reprint author), Army Res Lab, Adelphi, MD 20783 USA.
EM tati@cse.psu.edu; str5004@cse.psu.edu; bongjun_ko@us.ibm.com;
gcao@cse.psu.edu; aswami@arl.army.mil; tlp@cse.psu.edu
FU US Army Research Laboratory; U.K. Ministry of Defence
[W911NF-06-3-0001]; Defense Threat Reduction Agency (DTRA)
FX This research was sponsored by the US Army Research Laboratory and the
U.K. Ministry of Defence and was accomplished under Agreement Number
W911NF-06-3-0001. The views and conclusions contained in this document
are those of the author(s) and should not be interpreted as representing
the official policies, either expressed or implied, of the US Army
Research Laboratory, the US Government, the U.K. Ministry of Defense or
the U.K. Government. The US and U.K. Governments are authorized to
reproduce and distribute reprints for Government purposes
notwithstanding any copyright notation hereon. In addition to ITA, this
research had been sponsored by Defense Threat Reduction Agency (DTRA).
NR 25
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PU IEEE COMPUTER SOC
PI LOS ALAMITOS
PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA
SN 1545-5971
EI 1941-0018
J9 IEEE T DEPEND SECURE
JI IEEE Trans. Dependable Secur. Comput.
PD MAY-JUN
PY 2016
VL 13
IS 3
BP 355
EP 368
DI 10.1109/TDSC.2014.2369051
PG 14
WC Computer Science, Hardware & Architecture; Computer Science, Information
Systems; Computer Science, Software Engineering
SC Computer Science
GA DM1EL
UT WOS:000376088100004
ER
PT J
AU Kotwal, RS
Champion, HR
Gross, KR
AF Kotwal, Russ S.
Champion, Howard R.
Gross, Kirby R.
TI A Military-Specific Injury Scoring System to Aid in Understanding the
Golden Hour Reply
SO JAMA SURGERY
LA English
DT Letter
ID COMBAT INJURY
C1 [Kotwal, Russ S.; Gross, Kirby R.] Joint Base San Antonio Ft Sam Houston, US Army Inst Surg Res, Joint Trauma Syst, Trauma Care Delivery, Ft Sam Houston, TX 78234 USA.
[Kotwal, Russ S.; Champion, Howard R.; Gross, Kirby R.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Kotwal, Russ S.] Texas A&M Hlth Sci Ctr, Coll Med, College Stn, TX USA.
RP Kotwal, RS (reprint author), Joint Base San Antonio Ft Sam Houston, US Army Inst Surg Res, Joint Trauma Syst, Trauma Care Delivery, Ft Sam Houston, TX 78234 USA.
EM russ.kotwal@us.army.mil
NR 4
TC 0
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U1 0
U2 0
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-6254
EI 2168-6262
J9 JAMA SURG
JI JAMA Surg.
PD MAY
PY 2016
VL 151
IS 5
BP 491
EP 492
DI 10.1001/jamasurg.2015.4895
PG 5
WC Surgery
SC Surgery
GA DM0CY
UT WOS:000376011600030
PM 26763674
ER
PT J
AU Hanson, JA
Lin, YH
Dretsch, MN
Strandjord, SE
Haub, MD
Hibbeln, JR
AF Hanson, Jennifer A.
Lin, Yu-Hong
Dretsch, Michael N.
Strandjord, Sarah E.
Haub, Mark D.
Hibbeln, Joseph R.
TI Whole food, functional food, and supplement sources of omega-3 fatty
acids and omega-3 HUFA scores among US soldiers
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Omega-3 fatty acids; Functional food; Food frequency questionnaire;
Docosahexaenoic acid; Eicosapentaenoic acid; Military personnel
ID POLYUNSATURATED FATTY-ACIDS; CORONARY-HEART-DISEASE; BODY-MASS INDEX;
FREQUENCY QUESTIONNAIRE; FISH CONSUMPTION; DEPRESSIVE SYMPTOMS;
COGNITIVE DECLINE; N-3; VALIDATION; ADULTS
AB A questionnaire to measure consumption of contemporary sources of omega-3 fatty acids including (i) seafood, (ii) poultry and eggs, (iii) omega-3 functional foods, and (iv) dietary supplements was completed by U.S. soldiers (N = 191). Omega-3 highly unsaturated fatty acid (HUFA) scores were higher (p < 0.01) among those who (i) took an omega-3 supplement, (ii) consumed sushi, (iii) consumed omega-3 functional foods, (iv) consumed beef less than twice per week, and (v) ate seafood at least twice a week. Omega-3 HUFA was positively correlated with EPA + DHA intake (beta = 0.39; p < 0.01) and age (beta = 0.14; p = 0.03) and negatively correlated with beef intake (beta = -0.13; p = 0.05) and smoking (beta = -0.12; p = 0.08). Intake of contemporary foods rich in omega-3s were associated with higher biomarker values while smoking and beef intake were associated with lower values. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Hanson, Jennifer A.; Haub, Mark D.] Kansas State Univ, Dept Food Nutr Dietet & Hlth, 212 Justin Hall, Manhattan, KS 66506 USA.
[Lin, Yu-Hong; Strandjord, Sarah E.; Hibbeln, Joseph R.] NIAAA, Sect Nutr Neurosci, Lab Membrane Biochem & Biophys, NIH, 5625 Fishers Lane,Rm 3N-07,MSC 9410, Bethesda, MD 20892 USA.
[Dretsch, Michael N.] US Army Aeromed Res Lab, Ft Rucker, AL USA.
[Dretsch, Michael N.] HQ TRADOC, Cognit Dominance Team, Human Dimens Div, Capabil Dev Directorate, Ft Eustis, VA 23604 USA.
[Strandjord, Sarah E.] Case Western Reserve Univ, Cleveland Clin, Lerner Coll Med, 9500 Euclid Ave NA21, Cleveland, OH USA.
RP Hanson, JA (reprint author), Kansas State Univ, Dept Food Nutr Dietet & Hlth, 212 Justin Hall, Manhattan, KS 66506 USA.
EM jhanson2@ksu.edu
OI Hanson, Jennifer /0000-0003-0437-6489
FU Academy of Nutrition and Dietetics Foundation; Intramural Research
Program of the National Institute on Alcohol Abuse and Alcoholism, NIH;
Kansas State University Research Foundation Fellowship Award
FX This project was partially funded by the Herbert D. and Nylda Gemple
Research Award from the Academy of Nutrition and Dietetics Foundation,
the Intramural Research Program of the National Institute on Alcohol
Abuse and Alcoholism, NIH and the Kansas State University Research
Foundation Fellowship Award.
NR 46
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U1 9
U2 19
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1756-4646
J9 J FUNCT FOODS
JI J. Funct. Food.
PD MAY
PY 2016
VL 23
BP 167
EP 176
DI 10.1016/j.jff.2016.02.017
PG 10
WC Food Science & Technology
SC Food Science & Technology
GA DM1ZK
UT WOS:000376145200016
ER
PT J
AU Kilianski, A
Nuzzo, JB
Modjarrad, K
AF Kilianski, Andy
Nuzzo, Jennifer B.
Modjarrad, Kayvon
TI Gain-of-Function Research and the Relevance to Clinical Practice
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Review
DE gain of function; potential pandemic pathogens; coronavirus; influenza;
science policy; health policy
ID EBOLA-VIRUS; MOUSE MODEL; DISEASE; TRANSMISSION; INHIBITORS; FERRETS;
RISKS; MICE; H7N9
AB The ongoing moratorium on gain-of-function (GOF) research with highly pathogenic avian influenza virus, severe acute respiratory syndrome coronavirus, and Middle East respiratory syndrome coronavirus has drawn attention to the current debate on these research practices and the potential benefits and risks they present. While much of the discussion has been steered by members of the microbiology and policy communities, additional input from medical practitioners will be highly valuable toward developing a broadly inclusive policy that considers the relative value and harm of GOF research. This review attempts to serve as a primer on the topic for the clinical community by providing a historical context for GOF research, summarizing concerns about its risks, and surveying the medical products that it has yielded.
C1 [Kilianski, Andy] Edgewood Chem Biol Ctr, BioSci Div, BioDefense Branch, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA.
[Nuzzo, Jennifer B.] Univ Pittsburgh, Med Ctr, Ctr Hlth Secur, Baltimore, MD USA.
[Modjarrad, Kayvon] US Mil HIV Res Program, Walter Reed Army Inst Res, Silver Spring, MD USA.
RP Kilianski, A (reprint author), Edgewood Chem Biol Ctr, BioSci Div, BioDefense Branch, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA.
EM andrew.kilianski.ctr@mail.mil
FU National Academy of Sciences; DTRA (National Research Council)
FX This work was supported by the National Academy of Sciences (to A. K.)
and the DTRA (National Research Council fellowship to A. K.).
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PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1899
EI 1537-6613
J9 J INFECT DIS
JI J. Infect. Dis.
PD MAY 1
PY 2016
VL 213
IS 9
BP 1364
EP 1369
DI 10.1093/infdis/jiv473
PG 6
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA DM4DM
UT WOS:000376295800003
PM 26416657
ER
PT J
AU Wang, YC
Wu, XM
Chen, J
Amin, R
Lu, M
Bhayana, B
Zhao, J
Murray, CK
Hamblin, MR
Hooper, DC
Dai, TH
AF Wang, Yucheng
Wu, Ximing
Chen, Jia
Amin, Rehab
Lu, Min
Bhayana, Brijesh
Zhao, Jie
Murray, Clinton K.
Hamblin, Michael R.
Hooper, David C.
Dai, Tianhong
TI Antimicrobial Blue Light Inactivation of Gram-Negative Pathogens in
Biofilms: In Vitro and In Vivo Studies
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
DE antimicrobial blue light; biofilm; Pseudomonas aeruginosa; Acinetobacter
baumannii; endogenous porphyrins; burn wound; mouse model;
bioluminescence imaging; HPLC; TUNEL assay
ID ACINETOBACTER-BAUMANNII INFECTION; RESISTANT STAPHYLOCOCCUS-AUREUS;
PSEUDOMONAS-AERUGINOSA BIOFILMS; WOUND INFECTIONS;
PROPIONIBACTERIUM-ACNES; ANTIBIOTIC TOLERANCE; HELICOBACTER-PYLORI;
OXYGEN LIMITATION; BACTERIA; MODEL
AB Background. Biofilms affect >80% bacterial infections in human and are usually difficult to eradicate because of their inherent drug resistance.
Methods. We investigated the effectiveness of antimicrobial blue light (aBL) (wavelength, 415 nm) for inactivatingAcinetobacter baumannii orPseudomonas aeruginosa biofilms in 96-well microplates or infected mouse burn wounds.
Results. In vitro, in 96-well microplates, exposure of 24-hour-old and 72-hour-oldA. baumannii biofilms to 432 J/cm(2) aBL resulted in inactivation of 3.59 log(10) and 3.18 log(10) colony-forming units (CFU), respectively. ForP. aeruginosa biofilms, similar levels of inactivation-3.02 log(10) and 3.12 log(10) CFU, respectively-were achieved. In mouse burn wounds infected with 5 x 10(6) CFU ofA. baumannii, approximately 360 J/cm(2) and 540 J/cm(2) aBL was required to inactivate 3 log(10) CFU in biofilms when delivered 24 and 48 hours, respectively, after bacterial inoculation. High-performance liquid chromatography analysis revealed the presence of endogenous porphyrins in bothA. baumannii andP. aeruginosa. TUNEL assay detected no apoptotic cells in aBL-irradiated mouse skin at up to 24 hours after aBL exposure (540 J/cm(2)).
Conclusions. aBL has antimicrobial activity in biofilms ofA. baumannii andP. aeruginosa and is a potential therapeutic approach for biofilm-related infections.
C1 [Wang, Yucheng] Chinese Peoples Liberat Army Gen Hosp, Dept Laser Med, Beijing 100853, Peoples R China.
[Wang, Yucheng] Nankai Univ, Coll Med, Tianjin 300071, Peoples R China.
[Chen, Jia] Shanghai Dermatol Hosp, Shanghai, Peoples R China.
[Wang, Yucheng; Wu, Ximing; Chen, Jia; Amin, Rehab; Lu, Min; Bhayana, Brijesh; Zhao, Jie; Hamblin, Michael R.; Dai, Tianhong] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Wellman Ctr Photomed, BAR 404B,55 Fruit St, Boston, MA 02114 USA.
[Hooper, David C.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Div Infect Dis, BAR 404B,55 Fruit St, Boston, MA 02114 USA.
[Hamblin, Michael R.] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA.
[Murray, Clinton K.] Brooke Army Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA.
RP Dai, TH (reprint author), Harvard Univ, Massachusetts Gen Hosp, Sch Med, Wellman Ctr Photomed, BAR 404B,55 Fruit St, Boston, MA 02114 USA.
EM tdai@mgh.harvard.edu
FU Center for Integration of Medicine and Innovative Technology under US
Army Medical Research Acquisition Activity [14-1894]; National
Institutes of Health [1R21AI109172]; American Society for Laser Medicine
and Surgery [BS.S02.15]
FX This work was supported by the Center for Integration of Medicine and
Innovative Technology, under a US Army Medical Research Acquisition
Activity Cooperative Agreement (award 14-1894 to T. D.); the National
Institutes of Health (1R21AI109172 to T. D.); and the American Society
for Laser Medicine and Surgery (student research grant BS.S02.15 to Y.
W.).
NR 45
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PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1899
EI 1537-6613
J9 J INFECT DIS
JI J. Infect. Dis.
PD MAY 1
PY 2016
VL 213
IS 9
BP 1380
EP 1387
DI 10.1093/infdis/jiw070
PG 8
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA DM4DM
UT WOS:000376295800005
PM 26908743
ER
PT J
AU Clapham, HE
Rodriguez-Barraquer, I
Azman, AS
Althouse, BM
Salje, H
Gibbons, RV
Rothman, AL
Jarman, RG
Nisalak, A
Thaisomboonsuk, B
Kalayanarooj, S
Nimmannitya, S
Vaughn, DW
Green, S
Yoon, IK
Cummings, DAT
AF Clapham, Hannah E.
Rodriguez-Barraquer, Isabel
Azman, Andrew S.
Althouse, Benjamin M.
Salje, Henrik
Gibbons, Robert V.
Rothman, Alan L.
Jarman, Richard G.
Nisalak, Ananda
Thaisomboonsuk, Butsaya
Kalayanarooj, Siripen
Nimmannitya, Suchitra
Vaughn, David W.
Green, Sharone
Yoon, In-Kyu
Cummings, Derek A. T.
TI Dengue Virus (DENV) Neutralizing Antibody Kinetics in Children After
Symptomatic Primary and Postprimary DENV Infection
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
DE dengue; neutralizing antibody; longitudinal antibody kinetics; vaccine
ID TIME-INTERVAL; DISEASE; THAILAND; TRANSMISSION; PROTECTION; SEVERITY;
ILLNESS; BURDEN; COHORT
AB The immune response to dengue virus (DENV) infection is complex and not fully understood. Using longitudinal data from 181 children with dengue in Thailand who were followed for up to 3 years, we describe neutralizing antibody kinetics following symptomatic DENV infection. We observed that antibody titers varied by serotype, homotypic vs heterotypic responses, and primary versus postprimary infections. The rates of change in antibody titers over time varied between primary and postprimary responses. For primary infections, titers increased from convalescence to 6 months. By comparing homotypic and heterotypic antibody titers, we saw an increase in type specificity from convalescence to 6 months for primary DENV3 infections but not primary DENV1 infections. In postprimary cases, there was a decrease in titers from convalescence up until 6 months after infection. Beginning 1 year after both primary and postprimary infections, there was evidence of increasing antibody titers, with greater increases in children with lower titers, suggesting that antibody titers were boosted due to infection and that higher levels of neutralizing antibody may be more likely to confer a sterilizing immune response. These findings may help to model virus transmission dynamics and provide baseline data to support the development of vaccines and therapeutics.
C1 [Clapham, Hannah E.; Rodriguez-Barraquer, Isabel; Azman, Andrew S.; Salje, Henrik; Cummings, Derek A. T.] Johns Hopkins Univ Bloomberg Sch Publ Hlth, Dept Epidemiol, 615 N Wolfe St, Baltimore, MD 21224 USA.
[Althouse, Benjamin M.] Inst Dis Modeling, Bellevue, WA USA.
[Althouse, Benjamin M.] Santa Fe Inst, Las Cruces, NM USA.
[Althouse, Benjamin M.] New Mexico State Univ, Las Cruces, NM 88003 USA.
[Gibbons, Robert V.] US Army, Inst Surg Res, San Antonio, TX USA.
[Rothman, Alan L.] Univ Rhode Isl, 825 Chalkstone Ave, Providence, RI 02908 USA.
[Cummings, Derek A. T.] Univ Florida, Dept Biol, Gainesville, FL USA.
[Cummings, Derek A. T.] Univ Florida, Emerging Pathogens Inst, Gainesville, FL USA.
[Green, Sharone] Univ Massachusetts, Sch Med, Div Infect Dis & Immunol, Worcester, MA USA.
[Jarman, Richard G.; Nisalak, Ananda; Thaisomboonsuk, Butsaya; Vaughn, David W.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand.
[Kalayanarooj, Siripen; Nimmannitya, Suchitra] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand.
[Clapham, Hannah E.; Yoon, In-Kyu] Int Vaccine Inst, Dengue Vaccine Initiat, Seoul, South Korea.
RP Clapham, HE (reprint author), Johns Hopkins Univ Bloomberg Sch Publ Hlth, 615 N Wolfe St, Baltimore, MD 21224 USA.
EM hannah.e.clapham@gmail.com
OI Azman, Andrew/0000-0001-8662-9077; Salje, Henrik/0000-0003-3626-4254
FU National Institutes of Health [P01 AI034533, R01 AI102939]; US Army
Medical Research and Materiel Command
FX This work was supported by the National Institutes of Health (grant P01
AI034533; grant R01 AI102939 to D. A. T. C.) and the US Army Medical
Research and Materiel Command.
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PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1899
EI 1537-6613
J9 J INFECT DIS
JI J. Infect. Dis.
PD MAY 1
PY 2016
VL 213
IS 9
BP 1428
EP 1435
DI 10.1093/infdis/jiv759
PG 8
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA DM4DM
UT WOS:000376295800010
PM 26704615
ER
PT J
AU Lin, JT
Ubalee, R
Lon, C
Balasubramanian, S
Kuntawunginn, W
Rahman, R
Saingam, P
Heng, TK
Vy, D
San, S
Nuom, S
Burkly, H
Chanarat, N
Ponsa, C
Levitz, L
Parobek, C
Chuor, CM
Somethy, S
Spring, M
Lanteri, C
Gosi, P
Meshnick, SR
Saunders, DL
AF Lin, Jessica T.
Ubalee, Ratawan
Lon, Chanthap
Balasubramanian, Sujata
Kuntawunginn, Worachet
Rahman, Rifat
Saingam, Piyaporn
Thay Kheang Heng
Dav Vy
San, Savoeun
Nuom, Sarath
Burkly, Hana
Chanarat, Nitima
Ponsa, Chanudom
Levitz, Lauren
Parobek, Christian
Chuor, Char Meng
Somethy, Sok
Spring, Michele
Lanteri, Charlotte
Gosi, Panita
Meshnick, Steven R.
Saunders, David L.
TI Microscopic Plasmodium falciparum Gametocytemia and Infectivity to
Mosquitoes in Cambodia
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
DE gametocyte; membrane feeding; infectious reservoir; malaria
transmission; Plasmodium falciparum; submicroscopic; Anopheles dirus
ID MALARIA INFECTIONS; TRANSMISSION; RELEVANCE
AB Although gametocytes are essential for malaria transmission, in Africa many falciparum-infected persons without smear-detectable gametocytes still infect mosquitoes. To see whether the same is true in Southeast Asia, we determined the infectiousness of 119 falciparum-infected Cambodian adults to Anopheles dirus mosquitoes by membrane feeding. Just 5.9% of subjects infected mosquitoes. The 8.4% of patients with smear-detectable gametocytes were >20 times more likely to infect mosquitoes than those without and were the source of 96% of all mosquito infections. In low-transmission settings, targeting transmission-blocking interventions to those with microscopic gametocytemia may have an outsized effect on malaria control and elimination.
C1 [Lin, Jessica T.; Balasubramanian, Sujata; Rahman, Rifat] Univ N Carolina, Sch Med, Div Infect Dis, 130 Mason Farm Rd,Ste 2115,CB 7030, Chapel Hill, NC 27599 USA.
[Levitz, Lauren; Meshnick, Steven R.] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, 130 Mason Farm Rd,Ste 2115,CB 7030, Chapel Hill, NC 27599 USA.
[Parobek, Christian] Univ N Carolina, Curriculum Genet & Mol Biol, 130 Mason Farm Rd,Ste 2115,CB 7030, Chapel Hill, NC 27599 USA.
[Ubalee, Ratawan; Ponsa, Chanudom] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand.
[Kuntawunginn, Worachet; Saingam, Piyaporn; Burkly, Hana; Chanarat, Nitima; Spring, Michele; Lanteri, Charlotte; Gosi, Panita; Saunders, David L.] Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand.
[Lon, Chanthap; Nuom, Sarath] Armed Forces Res Inst Med Sci, Phnom Penh, Cambodia.
[Thay Kheang Heng; Chuor, Char Meng] Natl Malaria Ctr, Phnom Penh, Cambodia.
[Dav Vy; Somethy, Sok] Royal Cambodian Armed Forces, Phnom Penh, Cambodia.
[San, Savoeun] Battambang Referral Hosp, Battambang, Cambodia.
RP Lin, JT (reprint author), Univ N Carolina, Div Infect Dis, 130 Mason Farm Rd,Ste 2115,CB 7030, Chapel Hill, NC 27599 USA.
EM jessica_lin@med.unc.edu
FU Armed Forces Health Surveillance Center/Global Emerging Infections
Surveillance and Response System; Military Infectious Disease Research
Program; National Institute of Allergy and Infectious Diseases [K08
AI110651]; American Society of Tropical Medicine and Hygiene; Burroughs
Wellcome Fund
FX This work was supported by the Armed Forces Health Surveillance
Center/Global Emerging Infections Surveillance and Response System,
Military Infectious Disease Research Program, National Institute of
Allergy and Infectious Diseases (K08 AI110651 to J. T. L.), American
Society of Tropical Medicine and Hygiene (postdoctoral fellowship in
tropical infectious diseases to J. T. L. and Benjamin Kean travel
fellowship to Christian Parobek), and Burroughs Wellcome Fund
(aforementioned fellowship to J. T. L.).
NR 15
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PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1899
EI 1537-6613
J9 J INFECT DIS
JI J. Infect. Dis.
PD MAY 1
PY 2016
VL 213
IS 9
BP 1491
EP 1494
DI 10.1093/infdis/jiv599
PG 4
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA DM4DM
UT WOS:000376295800019
PM 26667316
ER
PT J
AU Lin, JT
Meshnick, SR
Saunders, DL
Lon, C
AF Lin, Jessica T.
Meshnick, Steven R.
Saunders, David L.
Lon, Chanthap
TI Infectivity of Microscopic and Submicroscopic Malaria Parasite
Infections in Areas of Low Malaria Endemicity Reply
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Letter
ID RESERVOIR; THAILAND
C1 [Lin, Jessica T.] Univ N Carolina, Sch Med, Div Infect Dis, 130 Mason Farm Rd,Ste 2115,CB 7030, Chapel Hill, NC 27599 USA.
[Meshnick, Steven R.] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, 130 Mason Farm Rd,Ste 2115,CB 7030, Chapel Hill, NC 27599 USA.
[Saunders, David L.] Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand.
[Lon, Chanthap] Armed Forces Res Inst Med Sci, Phnom Penh, Cambodia.
RP Lin, JT (reprint author), Univ N Carolina, Div Infect Dis, 130 Mason Farm Rd,Ste 2115,CB 7030, Chapel Hill, NC 27599 USA.
EM jessica_lin@med.unc.edu
FU NIAID NIH HHS [K08 AI110651]
NR 5
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PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1899
EI 1537-6613
J9 J INFECT DIS
JI J. Infect. Dis.
PD MAY 1
PY 2016
VL 213
IS 9
BP 1517
EP 1517
DI 10.1093/infdis/jiw045
PG 1
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA DM4DM
UT WOS:000376295800023
PM 26908729
ER
PT J
AU Ensley, TR
Hu, HH
Reichert, M
Ferdinandus, MR
Peceli, D
Hales, JM
Perry, JW
Li, ZA
Jang, SH
Jen, AKY
Marder, SR
Hagan, DJ
Van Stryland, EW
AF Ensley, Trenton R.
Hu, Honghua
Reichert, Matthew
Ferdinandus, Manuel R.
Peceli, Davorin
Hales, Joel M.
Perry, Joseph W.
Li, Zhong'an
Jang, Sei-hum
Jen, Alex K. -Y.
Marder, Seth R.
Hagan, David J.
Van Stryland, Eric W.
TI Quasi-three-level model applied to measured spectra of nonlinear
absorption and refraction in organic molecules (vol 33, pg 780, 2016)
SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICS
LA English
DT Correction
C1 [Ensley, Trenton R.; Hu, Honghua; Reichert, Matthew; Ferdinandus, Manuel R.; Peceli, Davorin; Hagan, David J.; Van Stryland, Eric W.] Univ Cent Florida, Coll Opt & Photon, CREOL, Orlando, FL 32816 USA.
[Ensley, Trenton R.] US Army, Res Lab, Adelphi, MD 20783 USA.
[Ferdinandus, Manuel R.] Air Force Inst Technol, Dept Engn Phys, Dayton, OH 45433 USA.
[Hales, Joel M.; Perry, Joseph W.; Marder, Seth R.] Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA.
[Perry, Joseph W.; Li, Zhong'an; Marder, Seth R.] Georgia Inst Technol, Ctr Organ Photon & Elect, Atlanta, GA 30332 USA.
[Li, Zhong'an; Jang, Sei-hum; Jen, Alex K. -Y.] Univ Washington, Dept Mat Sci & Engn, Seattle, WA 98195 USA.
[Hagan, David J.; Van Stryland, Eric W.] Univ Cent Florida, Dept Phys, Orlando, FL 32816 USA.
RP Van Stryland, EW (reprint author), Univ Cent Florida, Coll Opt & Photon, CREOL, Orlando, FL 32816 USA.; Van Stryland, EW (reprint author), Univ Cent Florida, Dept Phys, Orlando, FL 32816 USA.
EM ewvs@creol.ucf.edu
RI Hagan, David/H-2204-2011; Reichert, Matthew/N-1191-2015
OI Hagan, David/0000-0003-2713-1767; Reichert, Matthew/0000-0003-1701-9376
NR 1
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U1 2
U2 4
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 0740-3224
EI 1520-8540
J9 J OPT SOC AM B
JI J. Opt. Soc. Am. B-Opt. Phys.
PD MAY 1
PY 2016
VL 33
IS 5
BP 1007
EP 1007
DI 10.1364/JOSAB.33.001007
PG 1
WC Optics
SC Optics
GA DM3JR
UT WOS:000376243200026
ER
PT J
AU Tassev, VL
Vangala, SR
Peterson, RD
Kimani, MM
Snure, M
Stites, RW
Guha, S
Slagle, JE
Ensley, TR
Syed, AA
Markov, IV
AF Tassev, Vladimir L.
Vangala, Shivashankar R.
Peterson, Rita D.
Kimani, Martin M.
Snure, Michael
Stites, Ronald W.
Guha, Shekhar
Slagle, Jonathan E.
Ensley, Trenton R.
Syed, Akbar A.
Markov, Ivan V.
TI Heteroepitaxial growth of OPGaP on OPGaAs for frequency conversion in
the IR and THz
SO OPTICAL MATERIALS EXPRESS
LA English
DT Article
ID GAP; GAAS; SUPERLATTICES; ABSORPTION; FILMS
AB For the first time thick orientation-patterned GaP (OPGaP) was repeatedly grown heteroepitaxially on OPGaAs templates as a quasi-phase matched medium for frequency conversion in the mid and longwave IR, and THz regions. The OP templates were fabricated by wafer-bonding and in a MBE-assisted polarity inversion process. Standard low-pressure hydride vapor phase epitaxy (LP-HVPE) was used for one-step growth of up to 400 mu m thick device quality OPGaP with excellent domain fidelity. The presented results can be viewed as the missing link between a well-developed technique for preparation of OP templates, using one robust nonlinear optical material (GaAs), and the subsequent thick epitaxial growth on them of another material (GaP). The reason for these efforts is that the second material has some indisputable advantages in point of view of thermal and optical properties but the preparation of native templates encounters challenges, which makes it difficult to obtain high quality homoepitaxial growth at an affordable price. Successful heteroepitaxial growth at such a relatively high lattice mismatch (- 3.6%) in a close to equilibrium growth process such as HVPE is noteworthy, especially when previously reported attempts, for example, growth of OPZnSe on OPGaAs templates at about 10 times smaller lattice mismatch (+ 0.3%) have produced only limited results. Combining the advantages of the two most promising nonlinear materials, GaAs and GaP, is a solution that will accelerate the development of high power, tunable laser sources for the IR and THz region, which are in great demand on the market. (C) 2016 Optical Society of America.
C1 [Tassev, Vladimir L.; Vangala, Shivashankar R.; Peterson, Rita D.; Kimani, Martin M.; Snure, Michael; Stites, Ronald W.; Guha, Shekhar; Slagle, Jonathan E.] US Air Force, Res Lab, Wright Patterson AFB, OH 45433 USA.
[Vangala, Shivashankar R.] SURVICE Eng Co, Dayton, OH 45431 USA.
[Kimani, Martin M.] WYLE, Aerosp Grp, 909 W Inyokern Rd Suite C, Ridgecrest, CA 93555 USA.
[Ensley, Trenton R.; Syed, Akbar A.] Univ Cent Florida, Coll Opt & Photon, CREOL, Orlando, FL 32816 USA.
[Ensley, Trenton R.] US Army, Res Lab, Adelphi, MD 20783 USA.
[Markov, Ivan V.] Bulgarian Acad Sci, Inst Phys Chem, Sofia, Bulgaria.
RP Tassev, VL (reprint author), US Air Force, Res Lab, Wright Patterson AFB, OH 45433 USA.
EM vladimir.tassev@wpafb.af.mil
FU Air Force Office for Scientific Research [13RY09COR]
FX This research was supported by the Air Force Office for Scientific
Research under funding 13RY09COR. The authors are very thankful to Prof.
Eric Van Stryland and Prof. David Hagan from UCF for the part of the
optical measurements conducted at CREOL.
NR 45
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PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 2159-3930
J9 OPT MATER EXPRESS
JI Opt. Mater. Express
PD MAY 1
PY 2016
VL 6
IS 5
BP 1724
EP 1737
DI 10.1364/OME.6.001724
PG 14
WC Materials Science, Multidisciplinary; Optics
SC Materials Science; Optics
GA DM3JF
UT WOS:000376242000033
ER
PT J
AU Marcsisin, SR
Reichard, G
Pybus, BS
AF Marcsisin, Sean R.
Reichard, Gregory
Pybus, Brandon S.
TI Primaquine pharmacology in the context of CYP 2D6 pharmacogenomics:
Current state of the art
SO PHARMACOLOGY & THERAPEUTICS
LA English
DT Review
DE Primaquine; CYP 2D6; 8-Aminoquinoline; Pharmacogenomics; Hepatic
metabolism; Plasmodium vivax
ID ANTIMALARIAL-DRUG PRIMAQUINE; PLASMODIUM-VIVAX MALARIA; INDUCED
HEMOLYTIC-ANEMIA; ADULT THAI SUBJECTS; INFECTION IN-VITRO;
CYTOCHROME-P450 2D6; PHARMACOKINETIC INTERACTIONS;
PYRONARIDINE-ARTESUNATE; GENETIC POLYMORPHISMS; HUMAN-ERYTHROCYTES
AB Primaquine is the only antimalarial drug available to clinicians for the treatment of relapsing forms of malaria. Primaquine development and usage dates back to the 1940s and has been administered to millions of individuals to treat and eliminate malaria infections. Primaquine therapy is not without disadvantages, however, as it can cause life threatening hemolysis in humans with glucose-6-phosphate dehydrogenase (G6PD) deficiency. In addition, the efficacy of primaquine against relapsing malaria was recently linked to CYP 2D6 mediated activation to an active metabolite, the structure of which has escaped definitive identification for over 75 years. CYP 2D6 is highly polymorphic among various human populations adding further complexity to a comprehensive understanding of primaquine pharmacology. This review aims to discuss primaquine pharmacology in the context of state of the art understanding of CYP 2D6 mediated 8-aminoquinoline metabolic activation, and shed light on the current knowledge gaps of 8-aminoquinoline mechanistic understanding against relapsing malaria. Published by Elsevier Inc. This is an open access article under the CC.BY-NC-ND license.
C1 [Marcsisin, Sean R.; Reichard, Gregory] Walter Reed Army Inst Res, Expt Therapeut Branch, Mil Malaria Res Program, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
[Pybus, Brandon S.] Dwight D Eisenhower Army Med Ctr, Dept Pathol, Ft Gordon, GA 30905 USA.
RP Marcsisin, SR (reprint author), Walter Reed Army Inst Res, Expt Therapeut Branch, Mil Malaria Res Program, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM sean.r.marcsisin.mil@mail.mil
FU Military Infectious Disease Research Program (MIDRP)
FX This work was supported in part by the Military Infectious Disease
Research Program (MIDRP). https://midrp.amedd.army.mil/,
NR 79
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U2 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0163-7258
J9 PHARMACOL THERAPEUT
JI Pharmacol. Ther.
PD MAY
PY 2016
VL 161
BP 1
EP 10
DI 10.1016/j.pharmthera.2016.03.011
PG 10
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA DL8IV
UT WOS:000375886600001
PM 27016470
ER
PT J
AU Waterman, BR
Rensing, N
Cameron, KL
Owens, BD
Pallis, M
AF Waterman, Brian R.
Rensing, Nicholas
Cameron, Kenneth L.
Owens, Brett D.
Pallis, Mark
TI Survivorship of Meniscal Allograft Transplantation in an Athletic
Patient Population
SO AMERICAN JOURNAL OF SPORTS MEDICINE
LA English
DT Article
DE meniscus; allograft transplantation; tear; extrusion
ID SHOULDER ARTHROPLASTY; CLINICAL-OUTCOMES; FOLLOW-UP; KNEE; SURGEON;
RECONSTRUCTION; SURVIVAL; VOLUME; RATES
AB Background:There are limited data evaluating the clinical outcomes of meniscal allograft transplantation (MAT) in physically active cohorts.
Purpose: To determine the survivorship, complication rates, and functional outcomes of MAT in an active military population.
Study Design: Case series; Level of evidence, 4.
Methods: All military patients undergoing MAT between 2007 and 2013 were identified from the Military Health System. Previous/concomitant procedures, perioperative complications, reoperation rate, revision, and initiation of medical discharge for persistent knee disability were recorded. Univariate analysis was performed to identify associations between patient-based and surgical variables on selected endpoints.
Results: A total of 230 MATs (227 patients; 228 knees) were identified; the mean patient age was 27.2 years (range, 18-46 years), and the cohort was predominately male (89%). Approximately half (51%) of the patients had undergone prior, nonmeniscal knee procedures. Medial MATs were performed in 160 (69%) cases, and isolated MATs were most common (60%). A total of 51 complications occurred in 46 (21.1%) patients, including a secondary tear or extrusion (9%). At a mean clinical follow-up of 2.14 years, 10 (4.4%) patients required secondary meniscal debridement, while 1 (0.4%) patient required revision MAT and 2 (0.9%) patients underwent total knee arthroplasty. After MAT, 50 (22%) patients underwent knee-related military discharge at a mean of 2.49 years postoperatively. Tobacco use (P = .028) was associated with significantly increased risk of failure, and operation by fellowship-trained surgeons trended toward significance as a protective factor (P = .078). Furthermore, high-volume surgeons (1 MAT/year; range, 9-35) had significantly reduced rates of failure (P = .046).
Conclusion: While reporting low reoperation and revision rates, this investigation indicates that 22% of patients with MAT were unable to return to military duty due to persistent knee limitations at short-term follow-up. Increased surgical experience may decrease rates of failure after MAT. Careful patient selection and referral to subspecialty-trained, higher-volume surgeons should be considered to optimize clinical outcomes after MAT.
C1 [Waterman, Brian R.; Rensing, Nicholas; Cameron, Kenneth L.; Owens, Brett D.; Pallis, Mark] William Beaumont Army Med Ctr, El Paso, TX 79920 USA.
[Waterman, Brian R.; Rensing, Nicholas; Pallis, Mark] William Beaumont Army Med Ctr, Dept Orthopaed Surg & Rehabil, El Paso, TX 79920 USA.
[Cameron, Kenneth L.; Owens, Brett D.] US Mil Acad, Keller Army Hosp, John A Feagin Jr Sports Med Fellowship, West Point, NY 10996 USA.
RP Owens, BD (reprint author), Brown Univ, Alpert Med Sch, Dept Orthopaed Surg, 100 Butler Dr, Providence, RI 02906 USA.
EM owensbrett@gmail.com
FU Mitek; Musculoskeletal Transplant Foundation
FX One or more of the authors has declared the following potential conflict
of interest or source of funding: B.D.O. is a paid consultant for Mitek
and the Musculoskeletal Transplant Foundation. M.P. owns stock or stock
options in Johnson & Johnson.
NR 28
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U1 0
U2 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0363-5465
EI 1552-3365
J9 AM J SPORT MED
JI Am. J. Sports Med.
PD MAY
PY 2016
VL 44
IS 5
BP 1237
EP 1242
DI 10.1177/0363546515626184
PG 6
WC Orthopedics; Sport Sciences
SC Orthopedics; Sport Sciences
GA DL4JD
UT WOS:000375599600020
PM 26888878
ER
PT J
AU Files, BT
Lawhern, VJ
Ries, AJ
Marathe, AR
AF Files, Benjamin T.
Lawhern, Vernon J.
Ries, Anthony J.
Marathe, Amar R.
TI A Permutation Test for Unbalanced Paired Comparisons of Global Field
Power
SO BRAIN TOPOGRAPHY
LA English
DT Article
DE Statistical test; Oddball paradigm; Data imbalance;
Electroencephalography
ID EVENT-RELATED POTENTIALS; MASS UNIVARIATE ANALYSIS; FALSE DISCOVERY
RATE; MISMATCH NEGATIVITY; BRAIN; DIFFERENCE; AVERAGE; TRIALS; WAVE
AB Global field power is a valuable summary of multi-channel electroencephalography data. However, global field power is biased by the noise typical of electroencephalography experiments, so comparisons of global field power on data with unequal noise are invalid. Here, we demonstrate the relationship between the number of trials that contribute to a global field power measure and the expected value of that global field power measure. We also introduce a statistical testing procedure that can be used for multi-subject, repeated-measures (also called within-subjects) comparisons of global field power when the number of trials per condition is unequal across conditions. Simulations demonstrate the effect of unequal trial numbers on global field power comparisons and show the validity of the proposed test in contrast to conventional approaches. Finally, the proposed test and two alternative tests are applied to data collected in a rapid serial visual presentation target detection experiment. The results show that the proposed test finds global field power differences in the classical P3 range; the other tests find differences in that range but also at other times including at times before stimulus onset. These results are interpreted as showing that the proposed test is valid and sensitive to real within-subject differences in global field power in multi-subject unbalanced data.
C1 [Files, Benjamin T.; Lawhern, Vernon J.; Ries, Anthony J.; Marathe, Amar R.] US Army, Res Lab, Aberdeen Proving Ground, MD USA.
RP Files, BT (reprint author), US Army, Res Lab, Aberdeen Proving Ground, MD USA.
EM benjamin.t.files.civ@mail.mil
FU U.S. Army Research Laboratory under a Director's Strategic Research
Initiative; Office of the Secretary of Defense ARPI program [MIPR
DWAM31168]
FX This project was supported by The U.S. Army Research Laboratory under a
Director's Strategic Research Initiative entitled "Heterogeneous Systems
for Information Variable Environments (HIVE)," an appointment to the
U.S. Army Research Laboratory Postdoctoral Fellowship program
administered by the Oak Ridge Associated Universities through a
cooperative agreement with the U.S. Army Research Laboratory and the
Office of the Secretary of Defense ARPI program MIPR DWAM31168. The
views and conclusions contained in this document are those of the
authors and should not be interpreted as representing the official
policies, either expressed or implied, of the Army Research Laboratory
or U.S. Government. The U.S. Government is authorized to reproduce and
distribute reprints for Government purposes notwithstanding any
copyright notation herein.
NR 35
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U2 5
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0896-0267
EI 1573-6792
J9 BRAIN TOPOGR
JI Brain Topogr.
PD MAY
PY 2016
VL 29
IS 3
BP 345
EP 357
DI 10.1007/s10548-016-0477-3
PG 13
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA DL7DH
UT WOS:000375799600001
PM 26936593
ER
PT J
AU Beard, JD
Engel, LS
Richardson, DB
Gammon, MD
Baird, C
Umbach, DM
Allen, KD
Stanwyck, CL
Keller, J
Sandler, DP
Schmidt, S
Kamel, F
AF Beard, John D.
Engel, Lawrence S.
Richardson, David B.
Gammon, Marilie D.
Baird, Coleen
Umbach, David M.
Allen, Kelli D.
Stanwyck, Catherine L.
Keller, Jean
Sandler, Dale P.
Schmidt, Silke
Kamel, Freya
TI Military service, deployments, and exposures in relation to amyotrophic
lateral sclerosis etiology
SO ENVIRONMENT INTERNATIONAL
LA English
DT Article
DE Amyotrophic lateral sclerosis; Case-control; Deployment; Etiology;
Military
ID MARGINAL STRUCTURAL MODELS; GULF-WAR VETERANS; MOTOR-NEURON DISEASE;
MILLENNIUM COHORT; NATIONAL REGISTRY; OCCUPATIONAL-EXPOSURE; ANTHRAX
VACCINATION; PESTICIDE EXPOSURE; VIETNAM VETERANS; TRAUMATIC EVENTS
AB Background: Factors underlying a possible excess of amyotrophic lateral sclerosis (ALS) among military veterans remain unidentified. Limitations of previous studies on this topic include reliance on ALS mortality as a surrogate for ALS incidence, low statistical power, and sparse information on military-related factors. Objectives: We evaluated associations between military-related factors and ALS using data from a case-control study of U.S. military veterans.
Methods: From 2005 to 2010, we identified medical record-confirmed ALS cases via the National Registry of Veterans with ALS and controls via the Veterans Benefits Administration's Beneficiary Identification and Records Locator System database. In total, we enrolled 621 cases and 958 frequency-matched controls in the Genes and Environmental Exposures in Veterans with Amyotrophic Lateral Sclerosis study. We collected information on military service and deployments and 39 related exposures. We used unconditional logistic regression models to estimate odds ratios (ORs) and 95% confidence intervals (CIs). We used inverse probability weighting to adjust for potential bias from confounding, missing covariate data, and selection arising from a case group that disproportionately included long-term survivors and a control group that may or may not differ from U.S. military veterans at large.
Results: The odds of ALS did not differ for veterans of the Air Force, Army, Marines, and Navy. We found higher odds of ALS for veterans whose longest deployment was World War II or the Korean War and a positive trend with total years of all deployments (OR = 1.27; 95% CI: 1.06, 1.52). ALS was positively associated with exposure to herbicides for military purposes, nasopharyngeal radium, personal pesticides, exhaust from heaters or generators, high-intensity radar waves, contaminated food, explosions within one mile, herbicides in the field, mixing and application of burning agents, burning agents in the field, and Agent Orange in the field, with ORs between 1.50 and 7.75.
Conclusions: Although our results need confirmation, they are potentially important given the large number of U.S. military veterans, and they provide clues to potential factors underlying the apparent increase of ALS in veteran populations. Published by Elsevier Ltd
C1 [Beard, John D.; Engel, Lawrence S.; Richardson, David B.; Gammon, Marilie D.] Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA.
[Beard, John D.; Sandler, Dale P.; Kamel, Freya] NIEHS, Epidemiol Branch, 111 TW Alexander Dr,A3-05, Res Triangle Pk, NC 27709 USA.
[Baird, Coleen] US Army Publ Hlth Command, Environm Med Program, Aberdeen Proving Ground, MD USA.
[Umbach, David M.] NIEHS, Biostat & Computat Biol Branch, 111 TW Alexander Dr,A3-05, Res Triangle Pk, NC 27709 USA.
[Allen, Kelli D.; Stanwyck, Catherine L.] Durham VA Med Ctr, Durham, NC USA.
[Allen, Kelli D.] Univ N Carolina, Dept Med, Chapel Hill, NC USA.
[Allen, Kelli D.] Univ N Carolina, Thurston Arthrit Res Ctr, Chapel Hill, NC USA.
[Stanwyck, Catherine L.; Schmidt, Silke] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA.
[Keller, Jean] Westat Corp, Durham, NC USA.
RP Kamel, F (reprint author), NIEHS, Epidemiol Branch, 111 TW Alexander Dr,A3-05, Res Triangle Pk, NC 27709 USA.
EM kamel@niehs.nih.gov
OI Engel, Lawrence/0000-0001-9268-4830; Kamel, Freya/0000-0001-5052-6615;
Sandler, Dale/0000-0002-6776-0018
FU Intramural Research Program of the NIH; National Institute of
Environmental Health Sciences (NIEHS) [Z01 ES049005]; NIEHS [R01
ES13244, T32ES007018]; ALS Association [ALSA 1230]; CDC; National
Institute for Occupational Safety and Health [T42OH00867302]; U.S.
Department of Veterans Affairs (CSP) [500A]
FX This work was supported by the Intramural Research Program of the NIH,
National Institute of Environmental Health Sciences (NIEHS; Z01
ES049005), grants from the NIEHS (R01 ES13244) and the ALS Association
(ALSA 1230), and training grants from the NIEHS (T32ES007018) and the
CDC, National Institute for Occupational Safety and Health
(T42OH00867302). The National Registry of Veterans with ALS was
supported by the U.S. Department of Veterans Affairs (CSP #500A).
NR 59
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U1 2
U2 12
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0160-4120
EI 1873-6750
J9 ENVIRON INT
JI Environ. Int.
PD MAY
PY 2016
VL 91
BP 104
EP 115
DI 10.1016/j.envint.2016.02.014
PG 12
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA DL4TQ
UT WOS:000375630500011
PM 26923711
ER
PT J
AU van Harmelen, T
Zondervan-van den Beuken, EK
Brouwer, DH
Kuijpers, E
Fransman, W
Buist, HB
Ligthart, TN
Hincapie, I
Hischier, R
Linkov, I
Nowack, B
Studer, J
Hilty, L
Som, C
AF van Harmelen, Toon
Zondervan-van den Beuken, Esther K.
Brouwer, Derk H.
Kuijpers, Eelco
Fransman, Wouter
Buist, Harrie B.
Ligthart, Tom N.
Hincapie, Ingrid
Hischier, Roland
Linkov, Igor
Nowack, Bernd
Studer, Jennifer
Hilty, Lorenz
Som, Claudia
TI LICARA nanoSCAN - A tool for the self-assessment of benefits and risks
of nanoproducts
SO ENVIRONMENT INTERNATIONAL
LA English
DT Article
DE Risk assessment; Benefit assessment; Nanoproducts; Decision-making tool;
Sustainable nanotechnology; Life Cycle Assessment
ID NANOMATERIALS
AB The fast penetration of nanoproducts on the market under conditions of significant uncertainty of their environmental properties and risks to humans creates a need for companies to assess sustainability of their products. Evaluation of the potential benefits and risks to build a coherent story for communication with clients, authorities, consumers, and other stakeholders is getting to be increasingly important, but SMEs often lack the knowledge and expertise to assess risks and communicate them appropriately. This paper introduces LICARA nanoSCAN, a modular web based tool that supports SMEs in assessing benefits and risks associated with new or existing nanoproducts. This tool is unique because it is scanning both the benefits and risks over the nanoproducts life cycle in comparison to a reference product with a similar functionality in order to enable the development of sustainable and competitive nanoproducts. SMEs can use data and expert judgment to answer mainly qualitative and semi-quantitative questions as a part of tool application. Risks to public, workers and consumers are assessed, while the benefits are evaluated for economic, environmental and societal opportunities associated with the product use. The tool provides an easy way to visualize results as well as to identify gaps, missing data and associated uncertainties. The LICARA nanoSCAN has been positively evaluated by several companies and was tested in a number of case studies. The tool helps to develop a consistent and comprehensive argument on the weaknesses and strengths of a nanoproduct that may be valuable for the communication with authorities, clients and among stakeholders in the value chain. LICARA nanoSCAN identifies areas for more detailed assessments, product design improvement or application of risk mitigation measures. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [van Harmelen, Toon; Ligthart, Tom N.] TNO, Climate Air & Sustainabil, POB 80015, NL-3508 TA Utrecht, Netherlands.
[Zondervan-van den Beuken, Esther K.; Brouwer, Derk H.; Kuijpers, Eelco; Fransman, Wouter; Buist, Harrie B.] TNO, Risk Anal Prod Dev, POB 360, NL-3700 AJ Zeist, Netherlands.
[Hincapie, Ingrid; Hischier, Roland; Nowack, Bernd; Hilty, Lorenz; Som, Claudia] Swiss Fed Labs Mat Sci & Technol, Empa, Technol & Soc Lab, Lerchenfeldstr 5, CH-9014 St Gallen, Switzerland.
[Linkov, Igor] US Army Engineer Res & Dev Ctr, 696 Virginia Rd, Concord, MA 01742 USA.
[Studer, Jennifer; Hilty, Lorenz] Univ Zurich, Dept Informat, Informat & Sustainabil Res Grp, Binzmuhlestr 14, CH-8050 Zurich, Switzerland.
[Brouwer, Derk H.] Univ Witwatersrand, Sch Publ Hlth, 27 St Andrews Rd, ZA-2193 Johannesburg, South Africa.
[Linkov, Igor] Carnegie Mellon Univ, Pittsburgh, PA 15213 USA.
RP Zondervan-van den Beuken, EK (reprint author), TNO, Risk Anal Prod Dev, POB 360, NL-3700 AJ Zeist, Netherlands.
EM esther.zondervan@tno.nl
OI Hischier, Roland/0000-0002-1084-7665; Nowack, Bernd/0000-0002-5676-112X
FU European Union Seventh Framework Programme (FP7) [315494]
FX The research leading to these results received funding from the European
Union Seventh Framework Programme (FP7/2007-2013) under grant agreement
no. 315494 (LICARA).
NR 37
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U1 4
U2 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0160-4120
EI 1873-6750
J9 ENVIRON INT
JI Environ. Int.
PD MAY
PY 2016
VL 91
BP 150
EP 160
DI 10.1016/j.envint.2016.02.021
PG 11
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA DL4TQ
UT WOS:000375630500015
PM 26949868
ER
PT J
AU Whitman, GM
Wang, Q
Spector, P
Schwering, FK
AF Whitman, Gerald M.
Wang, Qi
Spector, Paul
Schwering, Felix K.
TI Gaussian Beam Scattering From a Deterministic Rough Metal Surface
SO IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION
LA English
DT Article
DE Correction current (CC) method; Gaussian beam scattering; rough surface
scattering
ID INHOMOGENEOUS MULTILAYERED STRUCTURES; ELECTROMAGNETIC WAVE-PROPAGATION;
TE-POLARIZATION; APPROXIMATION; THICKNESS
AB A full-wave theory of plane wave scattering from rough surfaces called the correction current (CC) method was recently developed. This paper extends the CC method to the more general case of beam wave scattering. Gaussian beams are assumed incident upon a deterministic metal rough surface. Scatter patterns based on the CC method are calculated and compared to scatter patterns determined by the method of moments solution of an electric field integral equation formulation of the scatter problem. It was shown that good agreement between these two solution methods is obtained for scatter surfaces for which the CC method is shown to satisfy conservation of power and an accuracy criterion.
C1 [Whitman, Gerald M.; Wang, Qi] New Jersey Inst Technol, Dept Elect & Comp Engn, Newark, NJ 07102 USA.
[Wang, Qi] Ohio State Univ, Dept Elect & Comp Engn, Columbus, OH 43210 USA.
[Spector, Paul] New Jersey Inst Technol, Dept Elect Engn, Newark, NJ 07102 USA.
[Schwering, Felix K.] US Army, CERDEC, Ft Monmouth, NJ 07703 USA.
RP Whitman, GM; Wang, Q (reprint author), New Jersey Inst Technol, Dept Elect & Comp Engn, Newark, NJ 07102 USA.; Wang, Q (reprint author), Ohio State Univ, Dept Elect & Comp Engn, Columbus, OH 43210 USA.
EM whitman@njit.edu; wang.3726@osu.edu
NR 13
TC 0
Z9 0
U1 2
U2 3
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0018-926X
EI 1558-2221
J9 IEEE T ANTENN PROPAG
JI IEEE Trans. Antennas Propag.
PD MAY
PY 2016
VL 64
IS 5
BP 1868
EP 1876
DI 10.1109/TAP.2016.2537383
PG 9
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA DL4HX
UT WOS:000375596100030
ER
PT J
AU Yamashita, H
Jayakumar, P
Sugiyama, H
AF Yamashita, Hiroki
Jayakumar, Paramsothy
Sugiyama, Hiroyuki
TI Physics-Based Flexible Tire Model Integrated With LuGre Tire Friction
for Transient Braking and Cornering Analysis
SO JOURNAL OF COMPUTATIONAL AND NONLINEAR DYNAMICS
LA English
DT Article
ID ABSOLUTE NODAL COORDINATE; 4-NODE SHELL ELEMENT; OPTIMAL SOLID SHELLS;
NONLINEAR ANALYSES; MULTILAYER COMPOSITES; TYRE MODEL; FORMULATION;
PLATE
AB In transient vehicle maneuvers, structural tire deformation due to the large load transfer causes abrupt change in normal contact pressure and slip distribution over the contact patch, and it has a dominant effect on characterizing the transient braking and cornering forces including the history-dependent friction-induced hysteresis effect. To account for the dynamic coupling of structural tire deformations and the transient tire friction behavior, a physics-based flexible tire model is developed using the laminated composite shell element based on the absolute nodal coordinate formulation and the distributed parameter LuGre tire friction model. In particular, a numerical procedure to integrate the distributed parameter LuGre tire friction model into the finite-element based spatial flexible tire model is proposed. To this end, the spatially discretized form of the LuGre tire friction model is derived and integrated into the finite-element tire model such that change in the normal contact pressure and slip distributions over the contact patch predicted by the deformable tire model enters into the spatially discretized LuGre tire friction model to predict the transient shear contact stress distribution. By doing so, the structural tire deformation and the LuGre tire friction force model are dynamically coupled in the final form of the equations, and these equations are integrated simultaneously forward in time at every time step. The tire model developed is experimentally validated and several numerical examples for hard braking and cornering simulation are presented to demonstrate capabilities of the physics-based flexible tire model developed in this study.
C1 [Yamashita, Hiroki] Univ Iowa, Dept Mech & Ind Engn, Seamans Ctr 2312, Iowa City, IA 52242 USA.
[Jayakumar, Paramsothy] US Army TARDEC, 6501 E 11 Mile Rd, Warren, MI 48397 USA.
[Sugiyama, Hiroyuki] Univ Iowa, Dept Mech & Ind Engn, Seamans Ctr 2416C, Iowa City, IA 52242 USA.
RP Sugiyama, H (reprint author), Univ Iowa, Dept Mech & Ind Engn, Seamans Ctr 2416C, Iowa City, IA 52242 USA.
EM hiroyuki-sugiyama@uiowa.edu
FU Automotive Research Center (ARC) [W56HZV-04-2-0001]; U.S. Army Tank
Automotive Research, Development and Engineering Center (TARDEC);
Yokohama Rubber Co., Ltd.
FX This research was supported by the Automotive Research Center (ARC) in
accordance with Cooperative Agreement No. W56HZV-04-2-0001 U.S. Army
Tank Automotive Research, Development and Engineering Center (TARDEC),
and Yokohama Rubber Co., Ltd. This material is declared a work of the
U.S. Government and is not subject to copyright protection in the United
States. Approved for public release; distribution is unlimited.
NR 49
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U1 6
U2 10
PU ASME
PI NEW YORK
PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA
SN 1555-1423
EI 1555-1415
J9 J COMPUT NONLIN DYN
JI J. Comput. Nonlinear Dyn.
PD MAY
PY 2016
VL 11
IS 3
AR 031017
DI 10.1115/1.4032855
PG 17
WC Engineering, Mechanical; Mechanics
SC Engineering; Mechanics
GA DJ2NF
UT WOS:000374040900017
ER
PT J
AU Abdullatif, J
Certal, V
Zaghi, S
Song, SA
Chang, ET
Gillespie, MB
Camacho, M
AF Abdullatif, Jose
Certal, Victor
Zaghi, Soroush
Song, Sungjin A.
Chang, Edward T.
Gillespie, M. Boyd
Camacho, Macario
TI Maxillary expansion and maxillomandibular expansion for adult OSA: A
systematic review and meta-analysis
SO JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
LA English
DT Review
DE Maxillary expansion; Maxillomandibular expansion; Sleep apnoea
syndromes; Systematic review; Meta-analysis
ID OBSTRUCTIVE SLEEP-APNEA
AB Objective: This study sought to systematically review the international literature for articles evaluating maxillary expansion and maxillomandibular expansion as treatments for obstructive sleep apnea (OSA) in adults and to perform a meta-analysis.
Data sources: Nine databases (including MEDLINE/PubMed).
Review methods: Searches were performed through January 8, 2016. The PRISMA statement was followed.
Results: Eight adult studies (39 patients) reported polysomnography and/or sleepiness outcomes. Six studies reported outcomes for maxillary expansion (36 patients), and the apnea-hypopnea index (AHI) decreased from a mean (M) +/- standard deviation (SD) of 24.3 +/- 27.5 [95% CI 153, 33.3] to 9.9 +/- 13.7 [95% CI 5.4, 14.4] events/hr (relative reduction: 593%). Maxillary expansion improved lowest oxygen saturation (LSAT) from a M +/- SD of 84.3 +/- 8.1% [95% CI 81.7, 87.0] to 86.9 +/- 5.6% [95% CI 85.1, 88.7]. Maxillomandibular expansion was reported in two studies (3 patients) and AHI decreased from a M +/- SD of 47.53 +/- 29.81 [95% CI -26.5 to 121.5] to 10.7 +/- 3.2 [95% CI 2.8, 18.6] events/hr (relative reduction: 77.5%). Maxillomandibular expansion improved LSAT from a M SD of 76.7 +/- 14.5% [95% CI 40.7, 112.7] to 89.3 +/- 3.1 [95% CI 81.6, 97].
Conclusion: The current literature demonstrates that maxillary expansion can improve and maxillomandibular expansion can possibly improve AHI and LSAT in adults; however, given the paucity of studies, these remain open for additional research efforts. (C) 2016 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.
C1 [Abdullatif, Jose] Hosp Bernardino Rivadavia, Dept Otorhinolaryngol, Buenos Aires, DF, Argentina.
[Certal, Victor] Hosp CUF, Sleep Med Ctr, Dept Otorhinolaryngol, Oporto, Portugal.
[Certal, Victor] Univ Porto, CINTESIS Ctr Res Hlth Technol & Informat Syst, Rua Campo Alegre 823, P-4100 Oporto, Portugal.
[Zaghi, Soroush] Stanford Hosp & Clin, Div Sleep Surg, Dept Otolaryngol Head & Neck Surg, Stanford, CA 95304 USA.
[Song, Sungjin A.; Chang, Edward T.] Tripler Army Med Ctr, Otolaryngol Head & Neck Surg, Honolulu, HI 96859 USA.
[Gillespie, M. Boyd] Med Univ S Carolina, Dept Otolaryngol Head & Neck Surg, Charleston, SC 29425 USA.
[Camacho, Macario] Tripler Army Med Ctr, Div Sleep Surg & Med, Otolaryngol Head & Neck Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
[Camacho, Macario] Stanford Hosp & Clin, Sleep Med Div, Dept Psychiat & Behav Sci, Stanford, CA 95304 USA.
RP Camacho, M (reprint author), Tripler Army Med Ctr, Div Sleep Surg & Med, Otolaryngol Head & Neck Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA.; Camacho, M (reprint author), Stanford Hosp & Clin, Sleep Med Div, Dept Psychiat & Behav Sci, Stanford, CA 95304 USA.
EM drcamachoent@yahoo.com
RI FMUP, CINTESIS/C-6631-2014
OI FMUP, CINTESIS/0000-0001-7248-2086
NR 23
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Z9 0
U1 3
U2 3
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 1010-5182
EI 1878-4119
J9 J CRANIO MAXILL SURG
JI J. Cranio-MaxilloFac. Surg.
PD MAY
PY 2016
VL 44
IS 5
BP 574
EP 578
DI 10.1016/j.jcms.2016.02.001
PG 5
WC Dentistry, Oral Surgery & Medicine; Surgery
SC Dentistry, Oral Surgery & Medicine; Surgery
GA DL6GS
UT WOS:000375738300007
PM 26948172
ER
PT J
AU Armstrong, MJ
Beris, AN
Rogers, SA
Wagner, NJ
AF Armstrong, Matthew J.
Beris, Antony N.
Rogers, Simon A.
Wagner, Norman J.
TI Dynamic shear rheology of a thixotropic suspension: Comparison of an
improved structure-based model with large amplitude oscillatory shear
experiments
SO JOURNAL OF RHEOLOGY
LA English
DT Article
ID YIELD-STRESS FLUIDS; MICELLAR-SOLUTIONS; HUMAN-BLOOD; VISCOSITY;
BEHAVIOR; FLOW; DISPERSIONS; LAOS; SYSTEMS; GEL
AB Rheological measurements on a model thixotropic suspension by Dullaert and Mewis [J. Non-Newtonian Fluid Mech. 139(1-2), 21-30 (2006); Rheol. Acta 45, 23-32 (2005)] are extended to include large amplitude oscillatory shear (LAOS) flow, shear flow reversal, and a novel unidirectional LAOS flow to provide an extended rheological data set for testing constitutive models. We use this extended data set to test a new structure-based model developed by improving the Delaware thixotropic model [A. Mujumdar et al., J. Non-Newtonian Fluid Mech. 102,157-178 (2002); A. J. Apostolidis et al., J. Rheol. 59, 275-298 (2015)]. Model parameters are determined from steady, small amplitude oscillatory, and step shear rate tests. Holding those parameters fixed, model predictions are compared to LAOS experiments. Similar comparisons are made for three contemporary models from the literature. Two of these models use a scalar internal structural parameter and include the modified Jeffreys model proposed by de Souza Mendes and Thompson [Rheol. Acta 52, 673-694 (2013)]. The third model is based on fluidity additivity [F. Bautista et al., J. Non-Newtonian Fluid Mech. 80, 93-113 (1999)]. A common weakness in all models is shown to be the use of scalar order parameters that cannot account for the reversal of flow directionality inherent in LAOS flow. This is further illustrated by comparison with flow reversal and unidirectional LAOS experiments. (C) 2016 The Society of Rheology.
C1 [Armstrong, Matthew J.; Beris, Antony N.; Rogers, Simon A.; Wagner, Norman J.] Univ Delaware, Dept Chem & Biomol Engn, Newark, DE 19716 USA.
[Armstrong, Matthew J.] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA.
[Rogers, Simon A.] Univ Illinois, Dept Chem & Biomol Engn, Champaign, IL 61801 USA.
RP Wagner, NJ (reprint author), Univ Delaware, Dept Chem & Biomol Engn, Newark, DE 19716 USA.
EM wagnemj@udel.edu
RI Wagner, Norman/B-6558-2012; Rogers, Simon/E-4215-2013
OI Wagner, Norman/0000-0001-9565-619X; Rogers, Simon/0000-0002-3432-5044
FU National Science Foundation [CBET 312146]; U.S. Army; Department of
Chemistry and Life Science, United States Military Academy
FX The authors acknowledge the support of the National Science Foundation
through Grant No. CBET 312146, the funding assistance from the U.S.
Army, and the Department of Chemistry and Life Science, United States
Military Academy. Paulo de Souza Mendes (PUC, Brazil) is gratefully
acknowledged for significant assistance with the UA models fitting and
for helpful suggestions throughout this work. The authors gratefully
acknowledge the contributions of Jan Mewis (KU Leuven, emeritus) for
help with the model system used in this work, as well as for many
helpful suggestions and guidance throughout this work. The views
expressed herein are those of the authors and do not reflect the
position of the United States Military Academy, the Department of the
Army, or the Department of Defense.
NR 60
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U1 10
U2 24
PU JOURNAL RHEOLOGY AMER INST PHYSICS
PI MELVILLE
PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA
SN 0148-6055
J9 J RHEOL
JI J. Rheol.
PD MAY-JUN
PY 2016
VL 60
IS 3
BP 433
EP 450
DI 10.1122/1.4943986
PG 18
WC Mechanics
SC Mechanics
GA DL8IZ
UT WOS:000375887000007
ER
PT J
AU Chaitaveep, N
Utachee, P
Chuenchitra, T
Karasavvan, N
Takeda, N
Kameoka, M
AF Chaitaveep, Nithinart
Utachee, Piraporn
Chuenchitra, Thippawan
Karasavvan, Nicos
Takeda, Naokazu
Kameoka, Masanori
TI Neutralization breadth and potency of serum derived from recently human
immunodeficiency virus type 1-infected Thai individuals
SO MICROBES AND INFECTION
LA English
DT Article
DE Recent HIV-1 infection; Neutralization; CRF01_AE; Thailand
ID HIV TYPE-1; FUSION INHIBITOR; ENV CLONES; ANTIBODIES; INFECTION;
SEROCONVERSION; PLASMA; ESCAPE; CELLS; ASSAY
AB Neutralizing antibody responses play important roles in controlling several viral infections including human immunodeficiency virus type 1 (HIV-1). Potent and broad neutralizing antibody responses have been reported in some HIV-1-infected individuals; therefore, elucidating the mechanisms underlying neutralizing antibody responses will provide important information for the development of anti-HIV-1 vaccines. We herein performed a comparative study on the neutralization breadth and potency of serum samples collected from Thai individuals recently and chronically infected with HIV-1. Neutralization tests using a series of envelope glycoproteins (Env)-recombinant viruses revealed that although several serum samples derived from recently infected individuals did not show any HIV-1-specific neutralizing activity, the remaining serum samples exhibited neutralizing activity not only for recombinant viruses with CRF01_AE Env, but also for viruses with subtypes B and C Env. Furthermore, some serum samples derived from recently infected individuals showed the neutralization potency. Our results may provide a deeper insight into the characteristics of neutralizing antibody responses that develop during the course of HIV-1 infection among individuals in Thailand. (C) 2016 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
C1 [Chaitaveep, Nithinart; Chuenchitra, Thippawan; Karasavvan, Nicos] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
[Utachee, Piraporn; Takeda, Naokazu] Thailand Japan Res Collaborat Ctr Emerging & Reem, Nonthaburi, Thailand.
[Takeda, Naokazu; Kameoka, Masanori] Osaka Univ, Microbial Dis Res Inst, Osaka, Japan.
[Kameoka, Masanori] Kobe Univ, Grad Sch Hlth Sci, Dept Int Hlth, Kobe, Hyogo, Japan.
RP Kameoka, M (reprint author), Kobe Univ, Grad Sch Hlth Sci, Dept Int Hlth, Suma Ku, 7-10-2 Tomogaoka, Kobe, Hyogo 6540142, Japan.
EM mkameoka@port.kobe-u.ac.jp
OI Kameoka, Masanori/0000-0001-5525-9915
FU Government Lottery Office of Thailand; Research Institute for Microbial
Diseases, Osaka University; program of the Japan Initiative for Global
Research Network on Infectious Diseases (J-GRID) by the Japan Agency for
Medical Research and Development (AMED)
FX We are grateful to the staff of the Armed Forces Research Institute of
Medical Sciences (AFRIMS), especially Dr. Sathit Pichyangkul and Mr.
Kosol Yongvanichit, for their valuable help with this study. This work
was supported in part by a research grant by the Government Lottery
Office of Thailand; a collaborative research grant by the Research
Institute for Microbial Diseases, Osaka University; and the program of
the Japan Initiative for Global Research Network on Infectious Diseases
(J-GRID) by the Japan Agency for Medical Research and Development
(AMED). The opinions or assertions presented in this study are the
private views of the authors and are not to be construed as reflecting
the official positions of the Royal Thai Army. The HIV-1 env genes,
pREJO4541.67, QH0692.42, ZM249M.PL1 and ZM53M.PB12, and cell lines,
U87.CD4.CXCR4 and U87.CD4.CCR5, were obtained through the AIDS Research
and Reference Reagent Program, Division of AIDS, NIAID, NIH. This
manuscript was proofread by Medical English Service (Kyoto, Japan).
NR 37
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Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1286-4579
EI 1769-714X
J9 MICROBES INFECT
JI Microbes Infect.
PD MAY
PY 2016
VL 18
IS 5
BP 346
EP 353
DI 10.1016/j.micinf.2015.12.009
PG 8
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA DL3XY
UT WOS:000375568200007
PM 26774333
ER
PT J
AU Mallick, LM
Mitchell, MM
Millikan-Bell, A
Gallaway, MS
AF Mallick, Lindsay M.
Mitchell, Mary M.
Millikan-Bell, Amy
Gallaway, M. Shayne
TI Small Unit Leader Perceptions of Managing Soldier Behavioral Health and
Associated Factors
SO MILITARY PSYCHOLOGY
LA English
DT Article
DE behavioral health; leadership; military; squad leaders
ID TRANSFORMATIONAL LEADERSHIP; COMBAT DEPLOYMENT; WORK ENGAGEMENT; SOCIAL
COHESION; SELF-STIGMA; CARE; BARRIERS; ATTITUDES; RESILIENCE; MILITARY
AB This investigation explored squad leaders' perceptions of their roles managing subordinate soldiers' behavioral health (BH) needs. The data were obtained through an anonymous survey of 458 squad leaders (i.e., small unit leaders who oversee 4-10 soldiers). More than 80% of squad leaders perceived management of soldier BH needs before, during, and after treatment as their responsibility, and felt comfortable and capable of executing these roles. Latent class analysis was used to determine groups of "most active," "moderately active," and "least active" leaders. Multinomial logistic regression was used to compare the least and most active classes. The most active leaders were more likely to report high BH knowledge, dedication to a common purpose, and low levels of "associative" stigma. These results should inform leader management of soldier BH. Future research should examine active leader characteristics and whether evidence-based training can increase support for preventing and managing BH issues.
C1 [Mallick, Lindsay M.; Mitchell, Mary M.; Millikan-Bell, Amy; Gallaway, M. Shayne] US Army Publ Hlth Command, BSHOP, US Army Inst Publ Hlth, Aberdeen Proving Ground, MD 21010 USA.
RP Gallaway, MS (reprint author), US Army Publ Hlth Command, APG EA, 5158 Blackhawk Rd, Aberdeen, MD 21010 USA.
EM michael.gallaway@cdc.hhs.gov
NR 56
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Z9 0
U1 4
U2 4
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0899-5605
EI 1532-7876
J9 MIL PSYCHOL
JI Milit. Psychol.
PD MAY
PY 2016
VL 28
IS 3
BP 147
EP 161
DI 10.1037/mil0000101
PG 15
WC Psychology, Multidisciplinary
SC Psychology
GA DL6ZL
UT WOS:000375788500003
ER
PT J
AU Justin, GA
Chang, ET
Camacho, M
Brietzke, SE
AF Justin, Grant A.
Chang, Edward T.
Camacho, Macario
Brietzke, Scott E.
TI Transoral Robotic Surgery for Obstructive Sleep Apnea: A Systematic
Review and Meta-Analysis
SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY
LA English
DT Review
DE obstructive sleep apnea; transoral robotic surgery; TORS;
sleep-disordered breathing; base of tongue
ID HYPOPNEA SYNDROME; MIDLINE GLOSSECTOMY; TONGUE BASE; APNEA/HYPOPNEA
SYNDROME; LINGUAL TONSILLECTOMY; CLINICAL-EXPERIENCE; TORS;
UVULOPALATOPHARYNGOPLASTY; COMPLICATIONS; FEASIBILITY
AB Objective To perform a systematic review of the international biomedical literature evaluating the effectiveness, complications, and safety of transoral robotic surgery (TORS) for the treatment of obstructive sleep apnea (OSA).
Data Sources PubMed/MEDLINE, Embase, and EMB Reviews databases were searched up to November 27, 2015.
Review Methods Two authors systematically and independently searched for articles on TORS for the treatment of OSA in adults that reported either outcomes for the apnea-hypopnea index (AHI), lowest oxygen saturation percentage (LSAT) or changes in the Epworth Sleepiness Scale (ESS), and/or rates and types of complications associated with the operation.
Results In total, 181 records were identified and 16 articles met inclusion criteria. Transoral robotic surgery was almost always combined with other sleep surgery procedures. The summary estimate of the decrease in AHI using TORS as part of a multilevel surgical approach was 24.0 (95% confidence interval [CI], 22.1-25.8; P < .001, I-2 = 99%). The summary estimate of a decrease in ESS score was 7.2 (95% CI, 6.6-7.7; P < .001, I-2 = 99%) and of the overall surgical success (defined as AHI <20 and 50% reduction) was 48.2% (95% CI, 38.8%-57.7%; P < .001, I-2 = 99%). Three large studies reported on their total complication rates with an average of 22.3% (range, 20.5%-24.7%).
Conclusions The initial results for the use of TORS as part of a multilevel surgical approach for OSA are promising for select patients. However, the cost and morbidity may be greater than with other techniques offsetting its advantages in visualization and precision. More prospective studies are needed to determine the optimal role of this tool.
C1 [Justin, Grant A.] Uniformed Serv Univ Hlth Sci, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
[Chang, Edward T.; Camacho, Macario] Tripler Army Med Ctr, Dept Otolaryngol Head & Neck Surg, Honolulu, HI 96859 USA.
[Brietzke, Scott E.] Walter Reed Natl Mil Med Ctr, Dept Otolaryngol Head & Neck Surg, Bethesda, MD USA.
RP Justin, GA (reprint author), Uniformed Serv Univ Hlth Sci, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
EM grant.a.justin@gmail.com
NR 39
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U1 3
U2 4
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0194-5998
EI 1097-6817
J9 OTOLARYNG HEAD NECK
JI Otolaryngol. Head Neck Surg.
PD MAY
PY 2016
VL 154
IS 5
BP 835
EP 846
DI 10.1177/0194599816630962
PG 12
WC Otorhinolaryngology; Surgery
SC Otorhinolaryngology; Surgery
GA DL4HB
UT WOS:000375593800011
PM 26932967
ER
PT J
AU Hudspeth, M
Chen, WN
Zheng, J
AF Hudspeth, Matthew
Chen, Weinong
Zheng, James
TI Why the Smith theory over-predicts instant rupture velocities during
fiber transverse impact
SO TEXTILE RESEARCH JOURNAL
LA English
DT Article
DE fiber transverse impact; yarn; Kevlar (R); rupture velocity
ID FRAGMENT-SIMULATING PROJECTILES; NYLON BALLISTIC PANELS; SINGLE FIBERS;
CUT RESISTANCE; PENETRATION; FAILURE; YARNS; CLOTH
AB The effect of multi-axial loading on single Kevlar (R) KM2 fibers is explored with an emphasis on correlating the results to fiber/yarn transverse impact. A 0.30 caliber fragment simulation projectile (FSP) is slightly modified to act as a transverse loading indenter. Fiber failure angles are forced between similar to 0 degrees and 50 degrees in efforts to deduce the deleterious effect caused by such angles. Said angles are also enforced in order to create the geometry that would be produced at an impact velocity causing immediate fiber/yarn rupture in transverse impact experiments. The effect of fiber angle around the FSP indenter is experimentally studied along with an analysis of the specific angle causing immediate fiber failure. It is shown that there exists a demonstrative reduction in fiber longitudinal failure strain of KM2 filaments due to this multi-axial stress state, thereby questioning the recurrent assumption that fiber performance within a body armor system is dominated by failure in pure tension.
C1 [Hudspeth, Matthew; Chen, Weinong] Purdue Univ, Sch Aeronaut & Astronaut, W Lafayette, IN 47907 USA.
[Chen, Weinong] Purdue Univ, Sch Mat Engn, W Lafayette, IN 47907 USA.
[Zheng, James] US Army, Program Execut Off Soldier, Ft Belvoir, VA USA.
RP Chen, WN (reprint author), Purdue Univ, Sch Aeronaut & Astronaut, W Lafayette, IN 47907 USA.
EM wchen@purdue.edu
FU US Army Program Executive Office - Soldiers; Purdue University
FX This research was supported through a corporative agreement between US
Army Program Executive Office - Soldiers and Purdue University.
NR 39
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U1 2
U2 3
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0040-5175
EI 1746-7748
J9 TEXT RES J
JI Text. Res. J.
PD MAY
PY 2016
VL 86
IS 7
BP 727
EP 738
DI 10.1177/0040517515586158
PG 12
WC Materials Science, Textiles
SC Materials Science
GA DL6AS
UT WOS:000375719900006
ER
PT J
AU Skimmyhorn, W
AF Skimmyhorn, William
TI Assessing Financial Education: Evidence from Boot Camp
SO AMERICAN ECONOMIC JOURNAL-ECONOMIC POLICY
LA English
DT Article
ID INFORMATION; DECISIONS; LITERACY; OUTCOMES
AB This study estimates the effects of Personal Financial Management Course attendance and enrollment assistance using a natural experiment in the US Army. New enlistees' course attendance reduces the probability of having credit account balances, average balances, delinquencies, and adverse legal actions in the first year after the course, but it has no effects on accounts in the second year or credit scores in either year. The course and its enrollment assistance substantially increase retirement savings rates and average monthly contributions, with effects that persist through at least two years. The course has no significant effects on military labor market outcomes.
C1 [Skimmyhorn, William] US Mil Acad, Dept Social Sci, Off Econ & Manpower Anal, 607 Cullum Rd, West Point, NY 10996 USA.
RP Skimmyhorn, W (reprint author), US Mil Acad, Dept Social Sci, Off Econ & Manpower Anal, 607 Cullum Rd, West Point, NY 10996 USA.
EM william.skimmyhorn@usma.edu
NR 23
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Z9 3
U1 3
U2 7
PU AMER ECONOMIC ASSOC
PI NASHVILLE
PA 2014 BROADWAY, STE 305, NASHVILLE, TN 37203 USA
SN 1945-7731
EI 1945-774X
J9 AM ECON J-ECON POLIC
JI Am. Econ. J.-Econ. Policy
PD MAY
PY 2016
VL 8
IS 2
BP 322
EP 343
DI 10.1257/pol.20140283
PG 22
WC Economics
SC Business & Economics
GA DL2GZ
UT WOS:000375453000010
ER
PT J
AU Seehusen, DA
Egitto, EA
AF Seehusen, Dean A.
Egitto, Elizabeth A.
TI AntiViral Therapy for Bell Palsy
SO AMERICAN FAMILY PHYSICIAN
LA English
DT Article
ID STEROIDS
C1 [Seehusen, Dean A.; Egitto, Elizabeth A.] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA USA.
RP Seehusen, DA (reprint author), Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA USA.
NR 6
TC 0
Z9 0
U1 1
U2 1
PU AMER ACAD FAMILY PHYSICIANS
PI KANSAS CITY
PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA
SN 0002-838X
EI 1532-0650
J9 AM FAM PHYSICIAN
JI Am. Fam. Physician
PD MAY 1
PY 2016
VL 93
IS 9
BP 742
EP 743
PG 2
WC Primary Health Care; Medicine, General & Internal
SC General & Internal Medicine
GA DL1BW
UT WOS:000375368000004
PM 27175950
ER
PT J
AU Lazarus, N
Bedair, SS
AF Lazarus, N.
Bedair, S. S.
TI Improved power transfer to wearable systems through stretchable magnetic
composites
SO APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
LA English
DT Article
ID ELECTRONICS; INDUCTORS; DESIGN
AB The use of wireless power transfer is common in stretchable electronics since physical wiring can be easily destroyed as the system is stretched. This work presents the first demonstration of improved inductive power coupling to a stretchable system through the addition of a thin layer of ferroelastomeric material. A ferroelastomer, an elastomeric polymer loaded with magnetic particulates, has a permeability greater than one while retaining the ability to survive significant mechanical strains. A recently developed ferroelastomer composite based on sendust platelets within a soft silicone elastomer was incorporated into liquid metal stretchable inductors based on the liquid metal galinstan in fluidic channels. For a single-turn inductor, the maximum power transfer efficiency rises from 71 % with no backplane, to 81 % for a rigid ferrite backplane on the transmitter side alone, to 86 % with a ferroelastomer backplane on the receiver side as well. The coupling between a commercial wireless power transmitter coil with ferrite backplane to a five-turn liquid metal inductor was also investigated, finding an improvement in power transfer efficiency from 81 % with only a rigid backplane to 90 % with the addition of the ferroelastomer backplane. Both the single and multi-turn inductors were demonstrated surviving up to 50 % uniaxial applied strain.
C1 [Lazarus, N.; Bedair, S. S.] US Army, Res Lab, Sensors & Elect Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
RP Lazarus, N (reprint author), US Army, Res Lab, Sensors & Elect Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM nathan.lazarus2.civ@mail.mil
NR 22
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Z9 0
U1 5
U2 9
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0947-8396
EI 1432-0630
J9 APPL PHYS A-MATER
JI Appl. Phys. A-Mater. Sci. Process.
PD MAY
PY 2016
VL 122
IS 5
AR 543
DI 10.1007/s00339-016-0067-y
PG 7
WC Materials Science, Multidisciplinary; Physics, Applied
SC Materials Science; Physics
GA DL2EJ
UT WOS:000375445700056
ER
PT J
AU Jones, A
AF Jones, Alvin
TI Repeatable Battery for the Assessment of Neuropsychological Status:
Effort Index Cutoff Scores for Psychometrically Defined Malingering
Groups in a Military Sample
SO ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
LA English
DT Article
DE RBANS; Effort Index; Performance validity testing; Malingering; military
ID SYMPTOM VALIDITY TEST; TRAUMATIC BRAIN-INJURY; HENRY-HEILBRONNER INDEX;
RESPONSE BIAS SCALE; FAKE BAD SCALE; CLASSIFICATION ACCURACY;
NEUROCOGNITIVE DYSFUNCTION; DISABILITY CLAIMANTS; LIKELIHOOD RATIOS;
TEST-PERFORMANCE
AB Objective. This research examined cutoff scores for the Effort Index (EI), an embedded measure of performance validity, for the Repeatable Battery for the Assessment of Neuropsychological Status. EI cutoffs were explored for an active-duty military sample composed mostly of patients with traumatic brain injury.
Method. Four psychometrically defined malingering groups including a definite malingering, probable to definite malingering, probable malingering, and a combined group were formed based on the number of validity tests failed.
Results. Excellent specificities (0.97 or greater) were found for all cutoffs examined (EI >= 1 to EI >= 3). Excellent sensitivities (0.80 to 0.89) were also found for the definite malingering group. Sensitivities were 0.49 or below for the other groups. Positive and negative predictive values and likelihood ratios indicated that the cutoffs for EI were much stronger for ruling-in than ruling-out malingering. Analyses indicated the validity tests used to form the malingering groups were uncorrelated, which serves to enhance the validity of the formation of the malingering groups.
Conclusions. Cutoffs were similar to other research using samples composed predominantly of head-injured individuals.
C1 [Jones, Alvin] Womack Army Med Ctr, Ft Bragg, NC USA.
RP Jones, A (reprint author), Dept Behav Hlth, 2817 Riley Rd,Bldg 4-2817, Ft Bragg, NC 28310 USA.
EM alrobj@googlemail.com
NR 70
TC 0
Z9 0
U1 2
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0887-6177
EI 1873-5843
J9 ARCH CLIN NEUROPSYCH
JI Arch. Clin. Neuropsychol.
PD MAY
PY 2016
VL 31
IS 3
BP 273
EP 283
DI 10.1093/arclin/acw006
PG 11
WC Psychology, Clinical; Psychology
SC Psychology
GA DL1WX
UT WOS:000375424900008
PM 26972457
ER
PT J
AU Ratziu, V
Harrison, SA
Francque, S
Bedossa, P
Lehert, P
Serfaty, L
Romero-Gomez, M
Boursier, J
Abdelmalek, M
Caldwell, S
Drenth, JPH
Anstee, QM
Hum, D
Hanf, R
Roudot, A
Megnien, S
Staels, B
Sanyal, A
AF Ratziu, Vlad
Harrison, Stephen A.
Francque, Sven
Bedossa, Pierre
Lehert, Philippe
Serfaty, Lawrence
Romero-Gomez, Manuel
Boursier, Jerome
Abdelmalek, Manal
Caldwell, Steve
Drenth, Joost P. H.
Anstee, Quentin M.
Hum, Dean
Hanf, Remy
Roudot, Alice
Megnien, Sophie
Staels, Bart
Sanyal, Arun
CA GOLDEN-505 Investigator Study Grp
TI Elafibranor, an Agonist of the Peroxisome Proliferator-Activated
Receptor-alpha and -delta, Induces Resolution of Nonalcoholic
Steatohepatitis Without Fibrosis Worsening
SO GASTROENTEROLOGY
LA English
DT Article
DE PPARA; PPARD; NAFLD; fatty liver
ID FATTY LIVER-DISEASE; PLACEBO-CONTROLLED TRIAL; CLINICAL-OUTCOMES;
FOLLOW-UP; VITAMIN-E; PIOGLITAZONE; METABOLISM; MORTALITY; THERAPY;
GFT505
AB BACKGROUND & AIMS: Elafibranor is an agonist of the peroxisome proliferator-activated receptor-alpha and peroxisome proliferator-activated receptor-delta. Elafibranor improves insulin sensitivity, glucose homeostasis, and lipid metabolism and reduces inflammation. We assessed the safety and efficacy of elafibranor in an international, randomized, double-blind placebo-controlled trial of patients with nonalcoholic steatohepatitis (NASH). METHODS: Patients with NASH without cirrhosis were randomly assigned to groups given elafibranor 80 mg (n = 93), elafibranor 120 mg (n = 91), or placebo (n = 92) each day for 52 weeks at sites in Europe and the United States. Clinical and laboratory evaluations were performed every 2 months during this 1-year period. Liver biopsies were then collected and patients were assessed 3 months later. The primary outcome was resolution of NASH without fibrosis worsening, using protocol-defined and modified definitions. Data from the groups given the different doses of elafibranor were compared with those from the placebo group using step-down logistic regression, adjusting for baseline nonalcoholic fatty liver disease activity score. RESULTS: In intention-to-treat analysis, there was no significant difference between the elafibranor and placebo groups in the protocol-defined primary outcome. However, NASH resolved without fibrosis worsening in a higher proportion of patients in the 120-mg elafibranor group vs the placebo group (19% vs 12%; odds ratio = 2.31; 95% confidence interval: 1.02-5.24; P = .045), based on a post-hoc analysis for the modified definition. In post-hoc analyses of patients with nonalcoholic fatty liver disease activity score >= 4 (n = 234), elafibranor 120 mg resolved NASH in larger proportions of patients than placebo based on the protocol definition (20% vs 11%; odds ratio = 3.16; 95% confidence interval: 1.22-8.13; P = .018) and the modified definitions (19% vs 9%; odds ratio = 3.52; 95% confidence interval: 1.32-9.40; P = .013). Patients with NASH resolution after receiving elafibranor 120 mg had reduced liver fibrosis stages compared with those without NASH resolution (mean reduction of 0.65 +/- 0.61 in responders for the primary outcome vs an increase of 0.10 +/- 0.98 in nonresponders; P < .001). Liver enzymes, lipids, glucose profiles, and markers of systemic inflammation were significantly reduced in the elafibranor 120-mg group vs the placebo group. Elafibranor was well tolerated and did not cause weight gain or cardiac events, but did produce a mild, reversible increase in serum creatinine (effect size vs placebo: increase of 4.31 +/- 1.19 mmol/L; P < .001). CONCLUSIONS: A post-hoc analysis of data from trial of patients with NASH showed that elafibranor (120 mg/d for 1 year) resolved NASH without fibrosis worsening, based on a modified definition, in the intention-to-treat analysis and in patients with moderate or severe NASH. However, the predefined end point was not met in the intention to treat population. Elafibranor was well tolerated and improved patients' cardiometabolic risk profile. ClinicalTrials.gov number: NCT01694849.
C1 [Ratziu, Vlad] Univ Paris 06, Hosp Pitie Salpetriere, 47-83 Bd Hop, F-75013 Paris, France.
[Ratziu, Vlad] INSERM, Inst Cardiometab & Nutr, UMRS 938, Paris, France.
[Harrison, Stephen A.] Brooke Army Med Ctr, Dept Med Gastroenterol & Hepatol Serv, Ft Sam Houston, TX 78234 USA.
[Francque, Sven] Univ Antwerp, Univ Antwerp Hosp, Dept Gastroenterol & Hepatol, B-2020 Antwerp, Belgium.
[Bedossa, Pierre] Univ Paris Denis Diderot, Hop Beaujon, Dept Pathol, Paris, France.
[Lehert, Philippe] Univ Melbourne, Dept Psychiat, Melbourne, Vic, Australia.
[Lehert, Philippe] Univ Louvain UCL, Fac Econ, Louvain, Belgium.
[Serfaty, Lawrence] Univ Paris 06, Hop St Antoine, Paris, France.
[Romero-Gomez, Manuel] Hosp Univ Valme, Unit Clin Management Digest Dis, Seville, Spain.
[Romero-Gomez, Manuel] Hosp Univ Valme, CIBERehd, Seville, Spain.
[Boursier, Jerome] Univ Hosp, Hepatol Dept, Angers, France.
[Boursier, Jerome] LUNAM Univ, Angers, France.
[Abdelmalek, Manal] Duke Univ, Durham, NC USA.
[Caldwell, Steve] Univ Virginia, Div Gastroenterol & Hepatol, Charlottesville, VA USA.
[Drenth, Joost P. H.] Radboud Univ Nijmegen, Med Ctr, Dept Gastroenterol & Hepatol, NL-6525 ED Nijmegen, Netherlands.
[Anstee, Quentin M.] Newcastle Univ, Fac Med Sci, Inst Cellular Med, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.
[Hum, Dean; Hanf, Remy; Roudot, Alice; Megnien, Sophie] Genfit SA, Loos, France.
[Staels, Bart] Univ Lille, INSERM, UMR1011, Inst Pasteur Lille,European Genom Inst Diabet, Lille, France.
[Sanyal, Arun] Virginia Commonwealth Univ, Richmond, VA USA.
RP Ratziu, V (reprint author), Univ Paris 06, Hosp Pitie Salpetriere, 47-83 Bd Hop, F-75013 Paris, France.
EM vlad.ratziu@upmc.fr
RI Staels, Bart/N-9497-2016; Francque, Sven/E-4526-2017
OI Staels, Bart/0000-0002-3784-1503; Francque, Sven/0000-0002-7527-4714
NR 36
TC 33
Z9 33
U1 11
U2 15
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0016-5085
EI 1528-0012
J9 GASTROENTEROLOGY
JI Gastroenterology
PD MAY
PY 2016
VL 150
IS 5
BP 1147
EP +
DI 10.1053/j.gastro.2016.01.038
PG 18
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA DJ8QM
UT WOS:000374477200029
PM 26874076
ER
PT J
AU Bauer, CMC
Greer, DM
Kram, JJF
Kamelle, SA
AF Bauer, Callie M. Cox
Greer, Danielle M.
Kram, Jessica J. F.
Kamelle, Scott A.
TI Tumor diameter as a predictor of lymphatic dissemination in endometrioid
endometrial cancer
SO GYNECOLOGIC ONCOLOGY
LA English
DT Article
DE Endometrial cancer; Endometrioid; Lymphatic dissemination; Myometrial
invasion; Nodal metastatic disease; Tumor cell grade; Tumor diameter
ID GYNECOLOGIC-ONCOLOGY-GROUP; NODAL METASTASIS; RISK; LYMPHADENECTOMY;
CARCINOMA; CLASSIFICATION; HYSTERECTOMY; INVASION; TRIAL; SIZE
AB Objectives. To assess the utility of tumor diameter (TD) for predicting lymphatic dissemination (LD) and determining need for lymphadenectomy following diagnosis of endometrioid endometrial cancer.
Methods. Patients diagnosed with stage I-III endometrioid endometrial cancer during 2003-2013 who underwent complete lymphadenectomy during hysterectomy were studied. Intraoperative predictors of LD included TD, grade, myometrial invasion (MI), age, body mass index, and race/ethnicity. Candidate logistic regression models of LD were evaluated for model fit and predictive power.
Results. Of 737 cancer patients, 68 (9.2%) were node-positive. Single-variable models with only continuous TD (c-statistic 0.77, 95% CI 0.71-0.83) and dichotomous TD with 50-mm cut-off (TD50; c-statistic 0.73, 95% CI 0.67-0.78) were significantly more predictive than with the standard 20-mm cut-off (c-statistic 0.56, 95% CI 0.53-0.59). Overall, the most important LD predictors were TD50 and MI3rds (three-category form). The best candidate model (c-statistic 0.84, 95% CI 0.80-0.88) suggested odds of LD were five times greater for TD >50 mm than <= 50 mm (OR 4.91, 95% CI 2.73-8.82) and six and ten times greater for MI >33% to <= 66% (OR, 5.70; 95% CI, 2.25-14.5) and >66% (OR 10.2, 95% CI 4.11-25.4), respectively, than <= 33%. Best-model false-negative (0%) and positive (57.2%) rates demonstrated marked improvement over traditional risk-stratification false-negative (1.5%) and positive (762%) rates (c-statistic 0.77, 95% CI 0.72-0.82).
Conclusions. Tumor diameter is an important predictor of LD. Our risk model, containing modified forms of MI and TD, yielded a lower false-negative rate and can significantly decrease the number of lymphadenectomies performed on low-risk women. Published by Elsevier Inc.
C1 [Bauer, Callie M. Cox] Aurora Hlth Care, Aurora Sinai Med Ctr, Dept Obstet & Gynecol, Milwaukee, WI USA.
[Greer, Danielle M.; Kram, Jessica J. F.] Aurora Hlth Care, Aurora Sinai Med Ctr, Ctr Urban Populat, Aurora UW Med Grp, Milwaukee, WI USA.
[Kamelle, Scott A.] Aurora Hlth Care, Aurora St Lukes Med Ctr, Dept Oncol, Milwaukee, WI USA.
RP Bauer, CMC (reprint author), Brooke Army Med Ctr, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM callie.cox.bauer@gmail.com
OI Cox Bauer, Callie /0000-0002-9302-0881; Kram,
Jessica/0000-0001-9831-7353
NR 25
TC 1
Z9 1
U1 0
U2 0
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0090-8258
EI 1095-6859
J9 GYNECOL ONCOL
JI Gynecol. Oncol.
PD MAY
PY 2016
VL 141
IS 2
BP 199
EP 205
DI 10.1016/j.ygyno.2016.02.017
PG 7
WC Oncology; Obstetrics & Gynecology
SC Oncology; Obstetrics & Gynecology
GA DL0YJ
UT WOS:000375358200004
ER
PT J
AU Olwenyi, OA
Naluyima, P
Cham, F
Quinn, TC
Serwadda, D
Sewankambo, NK
Gray, RH
Sandberg, JK
Michael, NL
Wabwire-Mangen, F
Robb, ML
Eller, MA
AF Olwenyi, Omalla A.
Naluyima, Prossy
Cham, Fatim
Quinn, Thomas C.
Serwadda, David
Sewankambo, Nelson K.
Gray, Ronald H.
Sandberg, Johan K.
Michael, Nelson L.
Wabwire-Mangen, Fred
Robb, Merlin L.
Eller, Michael A.
TI Differential Associations of Interleukin 6 and Intestinal Fatty
Acid-Binding Protein With Progressive Untreated HIV-1 Infection in
Rakai, Uganda
SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
LA English
DT Article
DE HIV-1; AIDS; immune activation; inflammation; IL-6; IFABP
ID C-REACTIVE PROTEIN; IMMUNODEFICIENCY-VIRUS TYPE-1; T-CELL DEPLETION;
SYSTEMIC IMMUNE ACTIVATION; DISEASE PROGRESSION; MICROBIAL
TRANSLOCATION; GASTROINTESTINAL-TRACT; VIRAL LOAD; ANTIRETROVIRAL
THERAPY; PREDICT MORTALITY
AB The significance of HIV-associated immune activation and microbial translocation in Sub-Saharan African population remains poorly defined. We assessed biomarkers of inflammation, microbial translocation, and cellular activation and found most factors elevated in Ugandan HIV-1 seroconverters compared with community-matched controls. In contrast to previous findings in Western cohorts, C-reactive protein, neopterin, and intestinal fatty acid binding protein were not elevated. Higher T-cell activation and IL-6 were associated with faster disease progression. Surprisingly, intestinal fatty acid binding protein, indicative of enterocyte turnover, was higher in slow than in fast progressors. These data suggest differential relationships among biomarkers of intestinal barrier integrity and innate immune activation between developed countries and Sub-Saharan Africa.
C1 [Olwenyi, Omalla A.; Naluyima, Prossy; Cham, Fatim; Wabwire-Mangen, Fred] Makerere Univ Walter Reed Project, Kampala, Uganda.
[Naluyima, Prossy; Sandberg, Johan K.] Karolinska Univ, Huddinge Hosp, Karolinska Inst, Ctr Infect Med,Dept Med, Stockholm, Sweden.
[Cham, Fatim] Henry M Jackson Fdn Adv of Mil Med, Bethesda, MD USA.
[Quinn, Thomas C.] NIAID, Immunoregulat Lab, Div Intramural Res, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
[Quinn, Thomas C.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA.
[Serwadda, David; Wabwire-Mangen, Fred] Makerere Univ, Coll Hlth Sci, Sch Publ Hlth, Kampala, Uganda.
[Serwadda, David; Sewankambo, Nelson K.] Uganda Virus Res Inst, Rakai Hlth Sci Program, Entebbe, Uganda.
[Sewankambo, Nelson K.] Makerere Univ, Coll Hlth Sci, Fac Med, Kampala, Uganda.
[Gray, Ronald H.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA.
[Michael, Nelson L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
RP Eller, MA (reprint author), Walter Reed Army Inst, HJF, US Mil HIV Res Program MHRP, 503 Robert Grant Ave,1N11, Silver Spring, MD 20910 USA.
EM meller@hivresearch.org
FU Henry M. Jackson Foundation for the Advancement of Military Medicine,
Inc. [W81XWH-11-2-0174]; U.S. Army Medical Research and Materiel Command
[W81XWH-11-2-0174]
FX Supported by a cooperative agreement (W81XWH-11-2-0174) between the
Henry M. Jackson Foundation for the Advancement of Military Medicine,
Inc., and the U.S. Army Medical Research and Materiel Command.
NR 46
TC 0
Z9 0
U1 2
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1525-4135
EI 1077-9450
J9 JAIDS-J ACQ IMM DEF
JI JAIDS
PD MAY 1
PY 2016
VL 72
IS 1
BP 15
EP 20
PG 6
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA DK6WY
UT WOS:000375067600012
PM 26630672
ER
PT J
AU Yehuda, R
Hoge, CW
AF Yehuda, Rachel
Hoge, Charles W.
TI The Meaning of Evidence-Based Treatments for Veterans With Posttraumatic
Stress Disorder
SO JAMA PSYCHIATRY
LA English
DT Editorial Material
ID PTSD
C1 [Yehuda, Rachel] James J Peters Vet Affairs Med Ctr, Dept Psychiat, 130 W Kingsbridge Rd, Bronx, NY 10468 USA.
[Yehuda, Rachel] Icahn Sch Med Mt Sinai, New York, NY 10029 USA.
[Hoge, Charles W.] Walter Reed Army Inst Res, Silver Spring, MD USA.
RP Yehuda, R (reprint author), James J Peters Vet Affairs Med Ctr, Dept Psychiat, 130 W Kingsbridge Rd, Bronx, NY 10468 USA.
EM rachel.yehuda@mssm.edu
NR 7
TC 5
Z9 5
U1 0
U2 0
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-622X
EI 2168-6238
J9 JAMA PSYCHIAT
JI JAMA Psychiatry
PD MAY
PY 2016
VL 73
IS 5
BP 433
EP 434
DI 10.1001/jamapsychiatry.2015.2878
PG 2
WC Psychiatry
SC Psychiatry
GA DL2KD
UT WOS:000375462600002
PM 26886229
ER
PT J
AU O'Brien, CP
Jenness, GR
Dong, H
Vlachos, DG
Lee, IC
AF O'Brien, Casey P.
Jenness, Glen R.
Dong, Hong
Vlachos, Dionisios G.
Lee, Ivan C.
TI Deactivation of Pt/Al2O3 during propane oxidation at low temperatures:
Kinetic regimes and platinum oxide formation
SO JOURNAL OF CATALYSIS
LA English
DT Article
DE Kinetic regimes; Oxidation; Platinum oxide; Infrared spectroscopy
ID PHASE OXYGEN-ATOMS; IN-SITU OXIDATION; CO OXIDATION; CHEMISORBED OXYGEN;
CARBON-MONOXIDE; CATALYTIC-OXIDATION; SUBSURFACE OXYGEN; RATE
OSCILLATIONS; DEEP OXIDATION; PARTICLE-SIZE
AB The kinetics of propane oxidation over Pt/Al2O3 are investigated in this work as a function of O-2/C3H8 ratio in the 150-300 degrees C temperature range. At high O-2/C3H8 ratios, the platinum nanoparticles are saturated with oxygen and the reaction rate is zero-order with respect to the oxygen partial pressures in this regime. As the oxygen coverage decreases with decreasing O-2/C3H8 ratio, the reaction rate increases and the reaction order changes from zero-order to negative-order in the oxygen partial pressure. The reaction rate is controlled to a large extent by the oxygen coverage on the platinum nanoparticles. However, at lower temperatures and higher oxygen pressures there is a slow deactivation of the catalyst that cannot be explained by a slow change in the oxygen coverage. Diffuse reflectance infrared Fourier-transform spectroscopy (DRIFTS) of adsorbed CO was performed to track the evolution of the nanoparticle structure over the course of the propane oxidation reaction and to determine whether the slow deactivation was caused by reconstruction of the platinum nanoparticles. We found that the platinum nanoparticles are significantly reconstructed during the course of the reaction, including the formation of a platinum oxide (PtO) which has a characteristic CO-DRIFTS band at 2123 cm(-1). The extent of PtO formation decreases with increasing temperature and, as a result, deactivation of the catalyst is less severe at higher temperatures. Unexpectedly, increasing the oxygen partial pressure resulted in less PtO formation. We believe that a different platinum oxide phase (e.g. PtO2 or Pt3O4) is formed at higher oxygen pressures, which is reduced to metallic platinum during CO exposure at 25 degrees C, and therefore is not detectable by CO DRIFTS. These results are unique because they show how the nanoparticle structure evolves over many hours of propane oxidation, and how the temperature and oxygen pressure influence the reconstruction of the nanoparticles, which has implications for a wide range of reactions not limited to propane oxidation. Published by Elsevier Inc.
C1 [O'Brien, Casey P.; Dong, Hong; Lee, Ivan C.] US Army Res Lab, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
[Jenness, Glen R.; Vlachos, Dionisios G.] Univ Delaware, Catalysis Ctr Energy Innovat, Dept Chem & Biomol Engn, Newark, DE 19716 USA.
[Jenness, Glen R.; Vlachos, Dionisios G.] Univ Delaware, Ctr Catalyt Sci & Technol, Newark, DE 19716 USA.
RP Lee, IC (reprint author), US Army Res Lab, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM ivan.c.lee2.civ@mail.mil
OI Vlachos, Dionisios/0000-0002-6795-8403
FU U.S. Army Research Laboratory [W911NF-12-2-0019, W911NF-10-0047];
Catalysis Center for Energy Innovation, an Energy Frontier Research
Center - U.S. Dept. of Energy, Office of Science, Office of Basic Energy
Sciences [DE-SC0001004]
FX Research was sponsored by the U.S. Army Research Laboratory and was
accomplished under Cooperative Agreement Numbers W911NF-12-2-0019 and
W911NF-10-0047. The views and conclusions contained in this document are
those of the authors and should not be interpreted as representing the
official policies, either expressed or implied, of the Army Research
Laboratory or the U.S. Government. The U.S. Government is authorized to
reproduce and distribute reprints for Government purposes
notwithstanding any copyright notation herein. The DFT calculations were
conducted at UD and were supported as part of the Catalysis Center for
Energy Innovation, an Energy Frontier Research Center funded by the U.S.
Dept. of Energy, Office of Science, Office of Basic Energy Sciences
under Award Number DE-SC0001004.
NR 60
TC 0
Z9 0
U1 14
U2 42
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0021-9517
EI 1090-2694
J9 J CATAL
JI J. Catal.
PD MAY
PY 2016
VL 337
BP 122
EP 132
DI 10.1016/j.jcat.2016.02.012
PG 11
WC Chemistry, Physical; Engineering, Chemical
SC Chemistry; Engineering
GA DK4WG
UT WOS:000374920400014
ER
PT J
AU Wu, YQ
Lu, Z
Emdadi, L
Oh, SC
Wang, J
Lei, Y
Chen, HY
Tran, DT
Lee, IC
Liu, DX
AF Wu, Yiqing
Lu, Zheng
Emdadi, Laleh
Oh, Su Cheun
Wang, Jing
Lei, Yu
Chen, Huiyong
Tran, Dat T.
Lee, Ivan C.
Liu, Dongxia
TI Tuning external surface of unit-cell thick pillared MFI and MWW zeolites
by atomic layer deposition and its consequences on acid-catalyzed
reactions
SO JOURNAL OF CATALYSIS
LA English
DT Article
DE Unit-cell thick zeolite; Hierarchical zeolite; Acidity Atomic layer
deposition (ALD); Bronsted acid sites; Methane aromatization
ID MOLECULAR-SIEVE; INTERCALATION CHEMISTRY; SPATIAL-DISTRIBUTION; LAMELLAR
ZEOLITE; DIMETHYL ETHER; SITES; NANOSHEETS; PRECURSOR; BEHAVIOR;
ALUMINUM
AB The pillared MWW (PMWW or MCM-36) and pillared MFI (PMFI) zeolites are 2-dimensional (2D) catalytically active materials made by pillaring of layered MCM-22(P) and multilamellar MFI precursors, respectively. The single- or near single-unit-cell thick 2D microporous layers in PMWW and PMFI expose comparable number of external surface acid sites (i.e., acid sites enclosed in mesopores between zeolitic layers) to those in micropores, which become important or dominant contributor to the catalytic properties. Although the acidity and catalytic activities of PMWW and PMFI have been studied, modification of their external surfaces and its implications on catalytic reactions are not available. In the present study, we report the tailoring of external surfaces of PMWW and PMFI zeolites by atomic layer deposition (ALD) of silicon (ALD-Si) and aluminum (ALD-Al), respectively. The textural, acidic and catalytic properties of the ALD modified pillared zeolites were investigated using a variety of characterization methods. ALD-Al and ALD-Si modifications kept micropore almost intact, but resulted in significant reduction in mesopore volume and considerable changes in external surface composition and acidity. The catalytic tests showed that intrinsic catalytic behavior of Bronsted acid sites in ALD modified pillared zeolites was similar to their parent counterparts. In diffusion constrained parallel reactions, ALD of Al- or Si-species altered catalyst selectivity. In addition, ALD of Si-species on PMFI zeolite deactivated surface active sites, which resulted in improved catalytic activity in direct methane aromatization reactions under optimal ALD cycles. The study exemplified for the first time that ALD is an effective tool for tuning the surface properties of 2D unit-cell thick zeolites. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Wu, Yiqing; Emdadi, Laleh; Oh, Su Cheun; Liu, Dongxia] Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA.
[Lu, Zheng; Lei, Yu] Univ Alabama, Dept Chem & Mat Engn, Huntsville, AL 35899 USA.
[Wang, Jing; Chen, Huiyong] NW Univ Xian, Sch Chem Engn, Xian 710069, Shaanxi, Peoples R China.
[Tran, Dat T.; Lee, Ivan C.] US Army Res Lab, RDRL SED E, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
RP Liu, DX (reprint author), Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA.
EM liud@umd.edu
FU American Chemical Society Petroleum Research Fund (ACS-PRF)
[52089-DNI5]; National Science Foundation [NSF-CBET 1264599, 1351384];
Maryland NanoCenter and its NispLab; NSF as a MRSEC Shared Experimental
Facility; University of Maryland Energy Research Center (UMERC)
FX The authors gratefully acknowledge financial support from the American
Chemical Society Petroleum Research Fund (ACS-PRF, 52089-DNI5) and
National Science Foundation (NSF-CBET 1264599 and 1351384). We
acknowledge the support of Maryland NanoCenter and its NispLab. The
NispLab is supported in part by the NSF as a MRSEC Shared Experimental
Facility. Yiqing Wu thanks for the Hulka Energy Research Fellowship from
University of Maryland Energy Research Center (UMERC) to support his
research.
NR 66
TC 3
Z9 3
U1 31
U2 63
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0021-9517
EI 1090-2694
J9 J CATAL
JI J. Catal.
PD MAY
PY 2016
VL 337
BP 177
EP 187
DI 10.1016/j.jcat.2016.01.031
PG 11
WC Chemistry, Physical; Engineering, Chemical
SC Chemistry; Engineering
GA DK4WG
UT WOS:000374920400020
ER
PT J
AU Stromdahl, EY
Nadolny, RM
Gibbons, JA
Auckland, LD
Vince, MA
Elkins, CE
Murphy, MP
Hickling, GJ
Eshoo, MW
Carolan, HE
Crowder, CD
Pilgard, MA
Hamer, SA
AF Stromdahl, Ellen Y.
Nadolny, Robyn M.
Gibbons, Jennifer A.
Auckland, Lisa D.
Vince, Mary A.
Elkins, Chad E.
Murphy, Michael P.
Hickling, Graham J.
Eshoo, Mark W.
Carolan, Heather E.
Crowder, Chris D.
Pilgard, Mark A.
Hamer, Sarah A.
TI Borrelia burgdorferi Not Confirmed in Human-Biting Amblyomma americanum
Ticks from the Southeastern United States (vol 53, pg 1698, 2015)
SO JOURNAL OF CLINICAL MICROBIOLOGY
LA English
DT Correction
C1 [Stromdahl, Ellen Y.; Nadolny, Robyn M.; Vince, Mary A.; Elkins, Chad E.; Murphy, Michael P.] US Army Publ Hlth Command, Aberdeen Proving Ground, MD USA.
[Nadolny, Robyn M.] Old Dominion Univ, Dept Biol Sci, Norfolk, VA 23529 USA.
[Gibbons, Jennifer A.] US Army Edgewood Chem & Biol Ctr, Aberdeen Proving Ground, MD USA.
[Gibbons, Jennifer A.] Sci & Technol Corp, Hampton, VA 23666 USA.
[Auckland, Lisa D.; Hamer, Sarah A.] Texas A&M Univ, Dept Vet Integrat Biosci, College Stn, TX USA.
[Hickling, Graham J.] Univ Tennessee, Inst Agr, Ctr Wildlife Hlth, Knoxville, TN 37901 USA.
[Eshoo, Mark W.; Carolan, Heather E.; Crowder, Chris D.] Ibis Biosci, Carlsbad, CA USA.
[Pilgard, Mark A.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO USA.
RP Stromdahl, EY (reprint author), US Army Publ Hlth Command, Aberdeen Proving Ground, MD USA.
NR 1
TC 0
Z9 0
U1 3
U2 3
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0095-1137
EI 1098-660X
J9 J CLIN MICROBIOL
JI J. Clin. Microbiol.
PD MAY
PY 2016
VL 54
IS 5
BP 1406
EP 1406
DI 10.1128/JCM.00527-16
PG 1
WC Microbiology
SC Microbiology
GA DK5JH
UT WOS:000374955700042
PM 27114565
ER
PT J
AU Gulgec, NS
Ergan, S
Akinci, B
Kelly, CJ
AF Gulgec, Nur Sila
Ergan, Semiha
Akinci, Burcu
Kelly, Christopher J.
TI Integrated Information Repository for Risk Assessment of Embankment
Dams: Requirements Identification for Evaluating the Risk of Internal
Erosion
SO JOURNAL OF COMPUTING IN CIVIL ENGINEERING
LA English
DT Article
DE Risk assessment; Internal erosion; Information requirement; Dams;
Information modeling
ID MODEL
AB Dams are continuing to age and deteriorate that affect the service life of the dams in the U.S. Risk assessment is required to understand the behavior of dams and to prioritize the remedial actions and maintenance, and yet it is quite challenging to do risk assessment since it requires extensive current and historical data from in situ instrumentation on dams and detailed design, construction, and operation information. Currently, the required data for risk assessment resides in various paper-based and digital documents that hinder the capabilities of risk assessors to gather, analyze, and visualize the data flexibly from various engineering perspectives such as geotechnical, hydrologic, geologic, and structural. As a result, getting a holistic view of a dam's current condition and its behavior over time becomes a time and resource intensive task. There is a need for an integrated shared knowledge repository for dams to streamline the risk assessment process. The research described in this paper provides requirements for developing such a shared knowledge repository for risk assessment of embankment dams that would support the information needs of various engineering domains and the means and methods for integrated assessment, visualization, and data analytics to understand the risk of internal erosion. (C) 2015 American Society of Civil Engineers.
C1 [Gulgec, Nur Sila] Lehigh Univ, Dept Civil & Environm Engn, 13 East Packer Ave, Bethlehem, PA 18015 USA.
[Ergan, Semiha] NYU, Dept Civil & Urban Engn, MetroTech Ctr 6, Polytech Sch Engn, Brooklyn, NY 11201 USA.
[Akinci, Burcu] Carnegie Mellon Univ, Dept Civil & Environm Engn, 5000 Forbes Ave, Pittsburgh, PA 15213 USA.
[Kelly, Christopher J.] US Army Corps Engineers, Risk Management Ctr, 1000 Liberty Ave, Pittsburgh, PA 15222 USA.
RP Gulgec, NS (reprint author), Lehigh Univ, Dept Civil & Environm Engn, 13 East Packer Ave, Bethlehem, PA 18015 USA.
EM nsg214@lehigh.edu; semiha@nyu.edu; bakinci@cmu.edu;
christopher.j.kelly2@usace.army.mil
NR 23
TC 0
Z9 0
U1 6
U2 7
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0887-3801
EI 1943-5487
J9 J COMPUT CIVIL ENG
JI J. Comput. Civil. Eng.
PD MAY
PY 2016
VL 30
IS 3
AR 04015038
DI 10.1061/(ASCE)CP.1943-5487.0000509
PG 12
WC Computer Science, Interdisciplinary Applications; Engineering, Civil
SC Computer Science; Engineering
GA DK4DU
UT WOS:000374868100012
ER
PT J
AU Cerco, CF
AF Cerco, Carl F.
TI Conowingo Reservoir Sedimentation and Chesapeake Bay: State of the
Science
SO JOURNAL OF ENVIRONMENTAL QUALITY
LA English
DT Article
ID RIVER; MANAGEMENT; USA
AB The Conowingo Reservoir is situated on the Susquehanna River, immediately upstream of Chesapeake Bay, the largest estuary in the United States. Sedimentation in the reservoir provides an unintended benefit to the bay by preventing sediments, organic matter, and nutrients from entering the bay. The sediment storage capacity of the reservoir is nearly exhausted, however, and the resulting increase in loading of sediments and associated materials is a potential threat to Chesapeake Bay water quality. In response to this threat, the Lower Susquehanna River Watershed Assessment was conducted. The assessment indicates the reservoir is in a state of "dynamic equilibrium" in which sediment loads from the upstream watershed to the reservoir are balanced by sediments leaving the reservoir. Increased sediment loads are not a threat to bay water quality. Increased loads of associated organic matter and nutrients are, however, detrimental. Bottom-water dissolved oxygen declines of 0.1 to 0.2 g m(-3) are projected as a result of organic matter oxidation and enhanced eutrophication. The decline is small relative to normal variations but results in violations of standards enforced in a recently enacted total maximum daily load. Enhanced reductions in nutrient loads from the watershed are recommended to offset the decline in water quality caused by diminished retention in the reservoir. The assessment exposed several knowledge gaps that require additional investigation, including the potential for increased loading at flows below the threshold for reservoir scour and the nature and reactivity of organic matter and nutrients scoured from the reservoir bottom.
C1 [Cerco, Carl F.] US Army, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
RP Cerco, CF (reprint author), US Army, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM carl.f.cerco@usace.army.mil
NR 37
TC 0
Z9 0
U1 4
U2 11
PU AMER SOC AGRONOMY
PI MADISON
PA 677 S SEGOE RD, MADISON, WI 53711 USA
SN 0047-2425
EI 1537-2537
J9 J ENVIRON QUAL
JI J. Environ. Qual.
PD MAY-JUN
PY 2016
VL 45
IS 3
BP 882
EP 886
DI 10.2134/jeq2015.05.0230
PG 5
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA DK8EJ
UT WOS:000375159700016
PM 27136154
ER
PT J
AU Linker, LC
Batiuk, RA
Cerco, CF
Shenk, GW
Tian, R
Wang, P
Yactayo, G
AF Linker, Lewis C.
Batiuk, Richard A.
Cerco, Carl F.
Shenk, Gary W.
Tian, Richard
Wang, Ping
Yactayo, Guido
TI Influence of Reservoir Infill on Coastal Deep Water Hypoxia
SO JOURNAL OF ENVIRONMENTAL QUALITY
LA English
DT Article
ID CHESAPEAKE BAY; SEDIMENT LOAD; EUTROPHICATION; MODEL; TRENDS; BASIN
AB Ecological restoration of the Chesapeake through the Chesapeake Bay total maximum daily load (TMDL) requires the reduction of nitrogen, phosphorus, and sediment loads in the Chesapeake watershed because of the tidal water quality impairments and damage to living resources they cause. Within the Chesapeake watershed, the Conowingo Reservoir has been filling in with sediment for almost a century and is now in a state of near-full capacity called dynamic equilibrium. The development of the Chesapeake TMDL in 2010 was with the assumption that the Conowingo Reservoir was still effectively trapping sediment and nutrients. This is now known not to be the case. In a TMDL, pollutant loads beyond the TMDL allocation, which are brought about by growth or other conditions, must be offset. Using the analysis tools of the Chesapeake TMDL for assessing the degree of water quality standard attainment, the estimated nutrient and sediment loads from a simulated dynamic equilibrium infill condition of the Conowingo Reservoir were determined. The influence on Chesapeake water quality by a large storm and scour event of January 1996 on the Susquehanna River was estimated, and the same storm and scour events were also evaluated in the more critical living resource period of June. An analysis was also made on the estimated influence of more moderate high flow events. The infill of the Conowingo reservoir had estimated impairments of water quality, primarily on deep-water and deep-channel dissolved oxygen, because of increased discharge and transport of organic and particulate inorganic nutrients from the Conowingo Reservoir.
C1 [Linker, Lewis C.; Batiuk, Richard A.; Shenk, Gary W.] US EPA, Chesapeake Bay Program Off, 410 Severn Ave,Suite 109, Annapolis, MD 21403 USA.
[Cerco, Carl F.] US Army, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
[Tian, Richard; Yactayo, Guido] Univ Maryland, Ctr Environm Sci, Chesapeake Bay Program Off, 410 Severn Ave,Suite 109, Annapolis, MD 21403 USA.
[Wang, Ping] Virginia Inst Marine Sci, Chesapeake Bay Off, 410 Severn Ave, Annapolis, MD 21403 USA.
RP Linker, LC (reprint author), US EPA, Chesapeake Bay Program Off, 410 Severn Ave,Suite 109, Annapolis, MD 21403 USA.
EM LLinker@chesapeakebay.net
NR 38
TC 2
Z9 2
U1 3
U2 10
PU AMER SOC AGRONOMY
PI MADISON
PA 677 S SEGOE RD, MADISON, WI 53711 USA
SN 0047-2425
EI 1537-2537
J9 J ENVIRON QUAL
JI J. Environ. Qual.
PD MAY-JUN
PY 2016
VL 45
IS 3
BP 887
EP 893
DI 10.2134/jeq2014.11.0461
PG 7
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA DK8EJ
UT WOS:000375159700017
PM 27136155
ER
PT J
AU Cerco, CF
Noel, MR
AF Cerco, Carl F.
Noel, Mark R.
TI Impact of Reservoir Sediment Scour on Water Quality in a Downstream
Estuary
SO JOURNAL OF ENVIRONMENTAL QUALITY
LA English
DT Article
ID CHESAPEAKE BAY; MODEL; SIMULATION; TRANSPORT; BUDGET; RECORD; USA; CD;
PB
AB The Conowingo Reservoir is situated at the lower terminus of the Susquehanna River watershed, immediately above Chesapeake Bay. Since construction, the reservoir has been filling with sediment to the point where storage capacity is nearly exhausted. The potential for release of accumulated sediments, organic matter, and nutrients, especially through the action of storm scour, causes concern for water quality in Chesapeake Bay. We used hydrodynamic and eutrophication models to examine the effects of watershed loads and scour loads on bay water quality under total maximum daily load conditions. Results indicate that increased suspended solids loads are not a threat to bay water quality. For most conditions, solids scoured from the reservoir settle out before the season during which light attenuation is critical. The organic matter and nutrients associated with the solids are, however, detrimental. This material settles to the estuary bottom and is mineralized in bed sediments. Carbon diagenesis spurs oxygen consumption in bottom sediments and in the water column via release of chemical oxygen demand. The nutrients are recycled to the water column and stimulate algal production. As a result of a scour event, bottom-water dissolved oxygen declines up to 0.2 g m(-3), although the decline is 0.1 g m(-3) or less when averaged over the summer season. Surface chlorophyll increases 0.1 to 0.3 mg m(-3) during the summer growing season.
C1 [Cerco, Carl F.; Noel, Mark R.] US Army, Environm Lab, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
RP Cerco, CF (reprint author), US Army, Environm Lab, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM carl.f.cerco@usace.army.mil
NR 39
TC 2
Z9 2
U1 9
U2 17
PU AMER SOC AGRONOMY
PI MADISON
PA 677 S SEGOE RD, MADISON, WI 53711 USA
SN 0047-2425
EI 1537-2537
J9 J ENVIRON QUAL
JI J. Environ. Qual.
PD MAY-JUN
PY 2016
VL 45
IS 3
BP 894
EP 905
DI 10.2134/jeq2014.10.0425
PG 12
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA DK8EJ
UT WOS:000375159700018
PM 27136156
ER
PT J
AU Hamele, M
Stockmann, C
Cirulis, M
Riva-Cambrin, J
Metzger, R
Bennett, TD
Bratton, SL
AF Hamele, Mitchell
Stockmann, Chris
Cirulis, Meghan
Riva-Cambrin, Jay
Metzger, Ryan
Bennett, Tellen D.
Bratton, Susan L.
TI Ventilator-Associated Pneumonia in Pediatric Traumatic Brain Injury
SO JOURNAL OF NEUROTRAUMA
LA English
DT Article
DE pediatric; pneumonia; traumatic brain injury
ID INTENSIVE-CARE-UNIT; RISK-FACTORS; NOSOCOMIAL PNEUMONIA; ACQUIRED
PNEUMONIA; CLINICAL-TRIAL; SAUDI-ARABIA; CHILDREN; HYPOTHERMIA;
SURVEILLANCE; INFECTION
AB Ventilator-associated pneumonia (VAP) is a common occurrence among intubated pediatric traumatic brain injury (TBI) patients. However, little is known about the epidemiology, risk factors, and microbiology of VAP in pediatric TBI. We reviewed a cohort of 119 pediatric moderate-to-severe TBI patients and identified 42 with VAP by positive protected bronchial brush specimens. Location of intubation, severity of injury, and antibiotic administration within 2 days after injury were not associated with VAP. Most treatments for elevated intracranial pressure were associated with increased risk of VAP; however, in a multi-variable analysis barbiturate coma (hazard ratio [HR], 3.2; 95% confidence interval [CI] 1.4-7.3), neuromuscular blockade (NMBA; HR, 3.4; 95% CI 1.6-7.3), and use of a cooling blanket for euthermia (HR 2.4; 95% CI 1.1-5.5) remained independently associated with VAP. Most VAP (55%) occurred prior to hospital Day 4 and only 7% developed VAP after Day 7. Methicillin-sensitive Staphylococcus aureus (34%), Haemophilus influenzae (22%), and Streptococcus pneumoniae (15%) were the most common organisms, comprising 71% of isolated pathogens (36% of infections were polymicrobial). Patients with VAP had significantly longer intensive care unit and hospital stays, as well as increased risk of chronic care needs after discharge, but not mortality. VAP is a common occurrence in pediatric TBI patients, and early empiric therapy for patients requiring barbiturate infusion, NMBA, or use of a cooling blanket could mitigate morbidity.
C1 [Hamele, Mitchell; Stockmann, Chris; Cirulis, Meghan; Bratton, Susan L.] Univ Utah, Sch Med, Dept Pediat, Salt Lake City, UT USA.
[Riva-Cambrin, Jay] Univ Utah, Sch Med, Dept Neurosurg, Salt Lake City, UT USA.
[Metzger, Ryan] Univ Utah, Sch Med, Div Pediat Surg, Salt Lake City, UT USA.
[Bennett, Tellen D.] Univ Colorado, Sch Med, Pediat Crit Care, Aurora, CO USA.
RP Hamele, M (reprint author), Univ Utah, Dept Pediat, US Army Med Corps, 295 Chipeta Way,POB 581289, Salt Lake City, UT 84158 USA.
EM mitchell.hamele@hsc.utah.edu
OI Bennett, Tellen/0000-0003-1483-4236
FU NICHD NIH HHS [K23 HD074620]
NR 34
TC 1
Z9 1
U1 2
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD MAY 1
PY 2016
VL 33
IS 9
BP 832
EP 839
DI 10.1089/neu.2015.4004
PG 8
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA DK7SA
UT WOS:000375124800005
PM 26203702
ER
PT J
AU Camacho, M
Dunn, B
Torre, C
Sasaki, J
Gonzales, R
Liu, SYC
Chan, DK
Certal, V
Cable, BB
AF Camacho, Macario
Dunn, Brandyn
Torre, Carlos
Sasaki, Jodie
Gonzales, Raymond
Liu, Stanley Yung-Chuan
Chan, Dylan K.
Certal, Victor
Cable, Benjamin B.
TI Supraglottoplasty for laryngomalacia with obstructive sleep apnea: A
systematic review and meta-analysis
SO LARYNGOSCOPE
LA English
DT Review
DE Obstructive sleep apnea; supraglottoplasty; laryngomalacia; systematic
review; meta-analysis
ID SURGICAL-TREATMENT; ASSISTED SUPRAGLOTTOPLASTY; APNEA/HYPOPNEA SYNDROME;
OCCULT LARYNGOMALACIA; RISK-FACTORS; FOLLOW-UP; OUTCOMES; CHILDREN;
INFANTS; ENDOSCOPY
AB Objectives/HypothesisTo determine if apnea-hypopnea index (AHI) and lowest oxygen saturation (LSAT) improve following isolated supraglottoplasty for laryngomalacia with obstructive sleep apnea (OSA) in children.
Study DesignSystematic review and meta-analysis.
MethodsNine databases, including PubMed/MEDLINE, were searched through September 30, 2015.
ResultsA total of 517 studies were screened; 57 were reviewed; and 13 met criteria. One hundred thirty-eight patients were included (age range: 1 month-12.6 years). Sixty-four patients had sleep exclusive laryngomalacia, and in these patients: 1) AHI decreased from a mean (M) standard deviation (SD) of 14.0 +/- 16.5 (95% confidence interval [CI] 10.0, 18.0) to 3.3 +/- 4.0 (95% CI 2.4, 4.4) events/hour (relative reduction: 76.4% [95% CI 53.6, 106.4]); 2) LSAT improved from a M +/- SD of 84.8 +/- 8.4% (95% CI 82.8, 86.8) to 87.6 +/- 4.4% (95% CI 86.6, 88.8); 3) standardized mean differences (SMD) demonstrated a small effect for LSAT and a large effect for AHI; and 4) cure (AHI < 1 event/hour) was 10.5% (19 patients with individual data). Seventy-four patients had congenital laryngomalacia, and in these patients: 1) AHI decreased from a M +/- SD of 20.4 +/- 23.9 (95% CI 12.8, 28.0) to 4.0 +/- 4.5 (95% CI 2.6, 5.4) events/hour (relative reduction: 80.4% [95% CI 46.6, 107.4]); 2) LSAT improved from a M +/- SD of 74.5 +/- 11.9% (95% CI 70.9, 78.1) to 88.4 +/- 6.6% (95% CI 86.4, 90.4); 3) SMD demonstrated a large effect for both AHI and LSAT; and 4) cure was 26.5% (38 patients with individual data).
ConclusionSupraglottoplasty has improved AHI and LSAT in children with OSA and either sleep exclusive laryngomalacia or congenital laryngomalacia; however, the majority of them are not cured. Laryngoscope, 126:1246-1255, 2016
C1 [Camacho, Macario; Cable, Benjamin B.] Tripler Army Med Ctr, Div Sleep Surg & Med, Otolaryngol Head & Neck Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
[Dunn, Brandyn; Sasaki, Jodie] Univ Hawaii, John A Burns Sch Med, Honolulu, HI 96822 USA.
[Camacho, Macario] Stanford Hosp & Clin, Sleep Med Div, Dept Psychiat & Behav Sci, San Francisco, CA USA.
[Torre, Carlos; Liu, Stanley Yung-Chuan] Stanford Hosp & Clin, Sleep Med Div, Dept Otolaryngol Head & Neck Surg, San Francisco, CA USA.
[Chan, Dylan K.] Univ Calif San Francisco, Div Pediat Otolaryngol, Dept Otolaryngol Head & Neck Surg, San Francisco, CA 94143 USA.
[Gonzales, Raymond] Uniformed Serv Univ Hlth Sci, Sch Med, Bethesda, MD 20814 USA.
[Certal, Victor] Univ Porto, Sleep Med Ctr, Dept Otorhinolaryngol, Hosp CUF, Rua Campo Alegre 823, P-4100 Oporto, Portugal.
[Certal, Victor] Univ Porto, CINTESIS Ctr Res Hlth Technol & Informat Syst, Rua Campo Alegre 823, P-4100 Oporto, Portugal.
RP Camacho, M (reprint author), Tripler Army Med Ctr, Div Sleep Surg & Med, Otolaryngol Head & Neck Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM drcamachoent@yahoo.com
RI FMUP, CINTESIS/C-6631-2014;
OI FMUP, CINTESIS/0000-0001-7248-2086; Camacho, Macario/0000-0001-9200-9085
NR 67
TC 5
Z9 5
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0023-852X
EI 1531-4995
J9 LARYNGOSCOPE
JI Laryngoscope
PD MAY
PY 2016
VL 126
IS 5
BP 1246
EP 1255
DI 10.1002/lary.25827
PG 10
WC Medicine, Research & Experimental; Otorhinolaryngology
SC Research & Experimental Medicine; Otorhinolaryngology
GA DK2UH
UT WOS:000374769400046
PM 26691675
ER
PT J
AU Burgess, E
AF Burgess, Edwin
TI Douglas MacArthur: American Warrior
SO LIBRARY JOURNAL
LA English
DT Book Review
C1 [Burgess, Edwin] US Army Combined Arms Res Lib, Ft Leavenworth, KS USA.
RP Burgess, E (reprint author), US Army Combined Arms Res Lib, Ft Leavenworth, KS USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU REED BUSINESS INFORMATION
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA
SN 0363-0277
J9 LIBR J
JI Libr. J.
PD MAY 1
PY 2016
VL 141
IS 8
BP 85
EP 86
PG 2
WC Information Science & Library Science
SC Information Science & Library Science
GA DK9IM
UT WOS:000375244100162
ER
PT J
AU Cesur, R
Sabia, JJ
AF Cesur, Resul
Sabia, Joseph J.
TI WHEN WAR COMES HOME: THE EFFECT OF COMBAT SERVICE ON DOMESTIC VIOLENCE
SO REVIEW OF ECONOMICS AND STATISTICS
LA English
DT Article
ID INTIMATE PARTNER VIOLENCE; POSTTRAUMATIC-STRESS-DISORDER;
SOCIAL-SECURITY DATA; MILITARY SERVICE; MENTAL-HEALTH; VIETNAM-ERA;
FAMILY VIOLENCE; DRAFT LOTTERY; CHILD-ABUSE; US ARMY
AB This study is the first to estimate the effect of war service in the Global War on Terrorism on domestic violence. We exploit a natural experiment in overseas deployment assignment among active-duty servicemen by relying on theoretical and empirical evidence that, conditional on military rank and occupation, deployment assignments are orthogonal to the propensity for violence. Our results show that assignment to combat substantially increases the probability of intimate partner violence and child abuse. Descriptive evidence suggests that the effects may be explained in part by the stress- and substance use-related consequences of war.
C1 [Cesur, Resul] Univ Connecticut, Mansfield, PA USA.
[Sabia, Joseph J.] Univ New Hampshire, Durham, NH 03824 USA.
[Sabia, Joseph J.] US Mil Acad, Washington, DC USA.
RP Cesur, R (reprint author), Univ Connecticut, Mansfield, PA USA.
FU National Institute of Child Health and Human Development [P01-HD31921]
FX This research uses data from Add Health, a program project designed by
J. Richard Udry, Peter S. Bearman, and Kathleen Mullan Harris, and
funded by a grant P01-HD31921 from the National Institute of Child
Health and Human Development, with cooperative funding from seventeen
other agencies.
NR 87
TC 0
Z9 0
U1 6
U2 17
PU MIT PRESS
PI CAMBRIDGE
PA ONE ROGERS ST, CAMBRIDGE, MA 02142-1209 USA
SN 0034-6535
EI 1530-9142
J9 REV ECON STAT
JI Rev. Econ. Stat.
PD MAY
PY 2016
VL 98
IS 2
BP 209
EP 225
DI 10.1162/REST_a_00541
PG 17
WC Economics; Social Sciences, Mathematical Methods
SC Business & Economics; Mathematical Methods In Social Sciences
GA DK3UF
UT WOS:000374842200001
ER
PT J
AU Seelig, AD
Jacobson, IG
Donoho, CJ
Trone, DW
Crum-Cianflone, NF
Balkin, TJ
AF Seelig, Amber D.
Jacobson, Isabel G.
Donoho, Carrie J.
Trone, Daniel W.
Crum-Cianflone, Nancy F.
Balkin, Thomas J.
TI Sleep and Health Resilience Metrics in a Large Military Cohort
SO SLEEP
LA English
DT Article
DE cohort; military; resilience; sleep
ID MILLENNIUM COHORT; US MILITARY; MENTAL-HEALTH; CARE UTILIZATION;
RISK-FACTORS; PRIME-MD; DEPRIVATION; PREVALENCE; DEPLOYMENT; PERSONNEL
AB Study Objectives: Examine the relationship between self-reported sleep parameters and indicators of resilience in a US military population (n = 55,021).
Methods: Longitudinal analyses (2001-2008) were conducted using subjective data collected from Millennium Cohort Study questionnaires and objective data from military records that included demographics, military health, and deployment information. Subjective sleep duration and insomnia symptoms were collected on the study questionnaire. Resilience metrics included lost work days, self-rated health, deployment, frequency and duration of health care utilization, and early discharge from the military. Generalized estimating equations and survival analyses were adjusted for demographic, military, behavioral, and health covariates in all models.
Results: The presence of insomnia symptoms was significantly associated with lower self-rated health, more lost work days, lower odds of deployment, higher odds of early discharge from military service early, and more health care utilization. Those self-reporting < 6 h (short sleepers) or > 8 h (long sleepers) of sleep per night had similar findings, except for the deployment outcome in which those with the shortest sleep were more likely to deploy.
Conclusions: Poor sleep is a detriment to service members' health and readiness. Leadership should redouble efforts to emphasize the importance of healthy sleep among military service members, and future research should focus on the efficacy of interventions to promote healthy sleep and resilience in this population.
C1 [Seelig, Amber D.; Jacobson, Isabel G.; Donoho, Carrie J.; Trone, Daniel W.; Crum-Cianflone, Nancy F.] Naval Hlth Res Ctr, San Diego, CA USA.
[Donoho, Carrie J.] Uniformed Serv Univ Hlth Sci, Dept Psychiat, Bethesda, MD 20814 USA.
[Crum-Cianflone, Nancy F.] Naval Med Ctr San Diego, San Diego, CA USA.
[Balkin, Thomas J.] Walter Reed Army Inst Res, Behav Biol Branch, Silver Spring, MD USA.
RP Jacobson, IG (reprint author), Naval Hlth Res Ctr, Deployment Hlth Res Dept, 140 Sylvester Rd, San Diego, CA 92106 USA.
EM Isabel.G.Jacobson.ctr@mail.mil
FU Military Operational Medicine Research Program of the US Army Medical
Research and Materiel Command, Fort Detrick, Maryland; Bureau of
Medicine and Surgery [60002]
FX This was not an industry supported study. The Millennium Cohort Study is
funded through the Military Operational Medicine Research Program of the
US Army Medical Research and Materiel Command, Fort Detrick, Maryland,
and the Bureau of Medicine and Surgery, under Work Unit No. 60002. The
views expressed in this article are those of the authors and do not
reflect the official policy or position of the Department of the Navy,
Department of the Army, Department of Defense, Department of Veterans
Affairs, or the US Government. Approved for public release; distribution
is unlimited. US Government Work (17 USC 105). Not copyrighted in the
US. This research has been conducted in compliance with all applicable
federal regulations governing the protection of human subjects in
research (Protocol NHRC. 2000.0007). The authors have indicated no
financial conflicts of interest.
NR 52
TC 1
Z9 1
U1 1
U2 3
PU AMER ACAD SLEEP MEDICINE
PI WESTCHESTER
PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA
SN 0161-8105
EI 1550-9109
J9 SLEEP
JI Sleep
PD MAY 1
PY 2016
VL 39
IS 5
BP 1111
EP 1120
AR PII sp-00323-15
DI 10.5665/sleep.5766
PG 10
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA DK8PE
UT WOS:000375188400019
PM 26951391
ER
PT J
AU Smith, JM
Bryant, MA
Wamsley, TV
AF Smith, Jane McKee
Bryant, Mary Anderson
Wamsley, Ty V.
TI Wetland buffers: numerical modeling of wave dissipation by vegetation
SO EARTH SURFACE PROCESSES AND LANDFORMS
LA English
DT Article
DE wetlands; wave dissipation; coastal storms; vegetation; nature-based
ID REDUCING STORM-SURGE; SALT-MARSH VEGETATION; ENERGY-DISSIPATION;
CLIMATE-CHANGE; ATTENUATION; MANGROVES; IMPACT; FIELD
AB The resiliency of coastal communities is imperative because these areas experience risk of damage from coastal storms as well as increasing population pressures and development. The severity of this hazard is compounded by sea level rise and a potential increase in storm intensities due to climate change. The ability of coastal communities to plan for, resist, and quickly and completely recover from severe coastal storm events and flooding is of critical importance. There is a growing interest in applying complementary and redundant approaches to reduce the flood risk of these vulnerable communities, such as incorporating natural and nature-based features into the project planning process. However, accounting for the benefits of these nature-based features in coastal design is still challenging. One of the natural features generally acknowledged to offer coastal protection benefits is wetlands. Using laboratory experiments of artificial vegetation as a foundation, the bounds of wave dissipation by vegetation are explored analytically and the effectiveness of wave dissipation by vegetation over large scales is investigated using the spectral wave model STWAVE. Wave heights modeled using a vegetation dissipation formulation are compared to those modeled with the current practice of representing vegetation using bottom friction, particularly the Manning formulation. The vegetation dissipation formulation reduced more wave energy than the Manning bottom friction formulation for submerged wetlands. Because the Manning formulation does not integrate vegetation properties, to achieve consistent results would require varying the Manning n coefficient to account for the spatial and temporal variation in form drag induced by the plants due to changes in plant density, diameter, and degree of plant submergence. Thus, a re-evaluation of existing methods for assessing wave dissipation by vegetation is recommended for wider application of vegetation dissipation formulations in numerical models. Such models are critical for evaluating coastal resiliency of communities protected by wetland features. Published 2016. This article is a U.S. Government work and is in the public domain in the USA.
C1 [Smith, Jane McKee; Bryant, Mary Anderson; Wamsley, Ty V.] US Army, Engn Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS USA.
RP Bryant, MA (reprint author), 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM Mary.Bryant@usace.army.mil
NR 41
TC 3
Z9 3
U1 10
U2 28
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0197-9337
EI 1096-9837
J9 EARTH SURF PROC LAND
JI Earth Surf. Process. Landf.
PD MAY
PY 2016
VL 41
IS 6
BP 847
EP 854
DI 10.1002/esp.3904
PG 8
WC Geography, Physical; Geosciences, Multidisciplinary
SC Physical Geography; Geology
GA DK1TP
UT WOS:000374697500009
ER
PT J
AU Ketter, P
Yu, JJ
Cap, AP
Forsthuber, T
Arulanandam, B
AF Ketter, Patrick
Yu, Jieh-Juen
Cap, Andrew P.
Forsthuber, Thomas
Arulanandam, Bernard
TI Pentraxin 3: an immune modulator of infection and useful marker for
disease severity assessment in sepsis
SO EXPERT REVIEW OF CLINICAL IMMUNOLOGY
LA English
DT Article
DE Pentraxin 3; PTX3; sepsis; coagulopathy; inflammation; pattern
recognition receptor; diagnostic markers; regulation
ID PATTERN-RECOGNITION RECEPTOR; C-REACTIVE PROTEIN; ACUTE
MYOCARDIAL-INFARCTION; TISSUE FACTOR EXPRESSION; ACUTE-PHASE PROTEINS;
SERUM AMYLOID-P; ASPERGILLUS-FUMIGATUS; DENDRITIC CELLS; INNATE
IMMUNITY; COMPLEMENT ACTIVATION
AB The acute phase protein pentraxin 3 (PTX3) is a pattern recognition receptor involved in regulation of the host immune response. This relatively newly discovered member of the pentraxin superfamily elicits both immunostimulatory and immunoregulatory functions preventing autoimmune pathology and orchestrated clearance of pathogens through opsonization of damage- and pathogen-associated molecular patterns (DAMP/PAMP). Thus, PTX3 has been described as a possible evolutionary precursor to immunoglobulins. While shown to provide protection against specific bacterial and fungal pathogens, persistent elevation of PTX3 levels following initial onset of infection appear to predict poor patient outcome and may contribute to disease sequelae such as tissue damage and coagulopathy. Measurement of PTX3 following onset of sepsis may improve patient risk assessment and thus be useful in guiding subsequent therapeutic interventions including steroidal anti-inflammatory and altered antibiotic therapies. In this review, we summarize the role of PTX3 in inflammatory syndromes and its utility as a marker of sepsis disease severity.
C1 [Ketter, Patrick; Cap, Andrew P.] US Army, Inst Surg Res, JBSA, Blood & Coagulat Program, Ft Sam Houston, TX USA.
[Yu, Jieh-Juen; Forsthuber, Thomas; Arulanandam, Bernard] Univ Texas San Antonio, Dept Biol, One UTSA Circle, San Antonio, TX 78249 USA.
RP Arulanandam, B (reprint author), Univ Texas San Antonio, One UTSA Circle, San Antonio, TX 78249 USA.
EM bernard.arulanandam@utsa.edu
FU U.S. Army Medical Research and Material Command; Army Research Office of
the Department of Defense [W911NF-11-1-0136]; U.S. Department of
Homeland Security [DHS 2014-ST-062-000058]; Alvarez Graduate Research
Education Excellence Fund
FX This research was partially funded by the U.S. Army Medical Research and
Material Command, the Army Research Office of the Department of Defense
[Contract Number: W911NF-11-1-0136], the U.S. Department of Homeland
Security [DHS 2014-ST-062-000058], and the Alvarez Graduate Research
Education Excellence Fund. The authors have no other relevant
affiliations or financial involvement with any organization or entity
with a financial interest in or financial conflict with the subject
matter or materials discussed in the manuscript apart from those
disclosed.
NR 92
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U1 4
U2 6
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1744-666X
EI 1744-8409
J9 EXPERT REV CLIN IMMU
JI Expert Rev. Clin. Immunol.
PD MAY
PY 2016
VL 12
IS 5
BP 501
EP 507
DI 10.1586/1744666X.2016.1166957
PG 7
WC Immunology
SC Immunology
GA DK1SJ
UT WOS:000374694100004
PM 26982005
ER
PT J
AU Gemeinhardt, TR
Gosch, NJC
Morris, DM
Miller, ML
Welker, TL
Bonneau, JL
AF Gemeinhardt, T. R.
Gosch, N. J. C.
Morris, D. M.
Miller, M. L.
Welker, T. L.
Bonneau, J. L.
TI Is Shallow Water a Suitable Surrogate for Assessing Efforts to Address
Pallid Sturgeon Population Declines?
SO RIVER RESEARCH AND APPLICATIONS
LA English
DT Article
DE shallow water; habitat restoration; pallid sturgeon; Missouri River
ID LOWER MISSOURI RIVER; SHOVELNOSE STURGEON; HABITAT USE; AGE-0 STURGEON;
FISHES; FLOW; FOOD; DISPERSAL; MONTANA; EXAMPLE
AB It is hypothesized that slow, shallow water habitats benefit larval pallid sturgeon Scaphirhynchus albus; however, testing this hypothesis is difficult, given the low number of larval pallid sturgeon present in large rivers. In contrast, relatively large numbers of age-0 shovelnose sturgeon Scaphirhynchus platorynchus have been sampled, providing a potentially useful baseline to assess the importance of slow, shallow water to age-0 sturgeon of both species (hereafter age-0 sturgeon) in the lower Missouri River. Thus, we investigated the potential relationships between the prevalence of shallow water <1.5m and the age-0 sturgeon catch rates at multiple scales. Age-0 sturgeon were usually sampled in water >1.5m, and catch rates were usually highest in the upper half [i.e. river kilometre (RKM) 400 to 800] of the lower Missouri River study area, whereas the availability of water <1.5m was usually highest in the lower half (i.e. RKM 0 to 400). Similarly, there was no relationship between age-0 sturgeon mean catch-per-unit effort and ha/km of water <1.5m at any studied scale. Our results may suggest that shallow water, as currently defined, may not be a suitable surrogate for assessing efforts to address pallid sturgeon population declines. However, it is still unknown if lack of appropriate habitat is currently limiting pallid sturgeon. Published 2015. This article is a U.S. Government work and is in the public domain in the USA. River Research and Applications published by John Wiley & Sons Ltd.
C1 [Gemeinhardt, T. R.; Gosch, N. J. C.; Morris, D. M.; Miller, M. L.] US Army Corps Engineers, Kansas City, MO USA.
[Welker, T. L.; Bonneau, J. L.] US Army Corps Engineers, Yankton, SD USA.
RP Gemeinhardt, TR (reprint author), US Army Corps Engineers, Kansas City, MO USA.
EM todd.r.gemeinhardt@usace.army.mil
FU USACE, Kansas City, and Omaha Districts
FX Funding was provided by the USACE, Kansas City, and Omaha Districts. We
thank the Nebraska Game and Parks Commission, Missouri Department of
Conservation, and USFWS for the PSPAP data access. Jason Farmer and
Chance Bitner provided valuable comments on an earlier draft of this
manuscript. Reference to trade names does not imply endorsement by the
US government. All product names and trademarks cited are the property
of their respective owners. The findings of this report are not to be
construed as an official Department of Army position unless so
designated by other authorized documents.
NR 48
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U1 4
U2 6
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1535-1459
EI 1535-1467
J9 RIVER RES APPL
JI River Res. Appl.
PD MAY
PY 2016
VL 32
IS 4
BP 734
EP 743
DI 10.1002/rra.2889
PG 10
WC Environmental Sciences; Water Resources
SC Environmental Sciences & Ecology; Water Resources
GA DK1WE
UT WOS:000374704900019
ER
PT J
AU Tripp, S
Killgore, KJ
Garvey, JE
AF Tripp, S.
Killgore, K. Jack
Garvey, J. E.
TI Fish Movements and Passage Through a Water Control Structure: River
Stage and Floodplain Connectivity
SO RIVER RESEARCH AND APPLICATIONS
LA English
DT Article
DE fish passage; floodplain connectivity; water control structure; river
stage
ID UPPER MISSISSIPPI RIVER; ASSEMBLAGES; CALIFORNIA; HABITATS
AB The St. John's Bayou water control structure near New Madrid, MO, connects the main Mississippi River to two large backwater areas called the New Madrid Floodway and St. John's Bayou. While this area has been altered, the New Madrid Floodway and St. John's Bayou account for the only substantial portion of the historic Mississippi River floodplain that remains and provides the only critical connection between backwater/floodplain habitat and the river. Fish passage was evaluated during April-December 2010 using ultrasonic telemetry. Stationary receivers were placed strategically at five locations above and below the structure in St. John's Bayou, in the floodway and the outlet to the Mississippi River. A total of 100 individuals representing 14 species were tagged. Total number of detections during an 8-month period was 1264717. Fifteen individuals representing five species moved into the Mississippi and Ohio rivers; seven individuals returned to St. John's Bayou. Thirteen of the 14 species moved upstream through the structure. Of the 85 individuals that stayed in the bayou, 29 fish passed through the structure for a total of 92 passage events. The downstream:upstream passage was roughly 50:50. Passage was correlated with river rise, with frequency of passage being higher in spring, but passage occurred each month during the study. Copyright (c) 2015 John Wiley & Sons, Ltd.
C1 [Tripp, S.] Missouri Dept Conservat, Big Rivers & Wetlands Field Stn, 3815 East Jackson Blvd, Jackson, MO 63755 USA.
[Killgore, K. Jack] US Army Corps Engineers, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS USA.
[Garvey, J. E.] So Illinois Univ, Dept Zool, Ctr Ecol, Ctr Fisheries Aquaculture & Aquat Sci, Carbondale, IL 62901 USA.
RP Tripp, S (reprint author), Missouri Dept Conservat, Big Rivers & Wetlands Field Stn, 3815 East Jackson Blvd, Jackson, MO 63755 USA.
EM sara.tripp@mdc.mo.gov
FU Ecosystem Management and Restoration Research Program at the Engineer
Research and Development Center
FX Funding was provided by the Memphis District, Mr Danny Ward, Project
Manager, and the Ecosystem Management and Restoration Research Program
at the Engineer Research and Development Center. Field assistance was
provided by ERDC-EL Fish Ecology Team (Jan Hoover, Steven George,
Bradley Lewis, Todd Slack, Jay Collins and Neil Douglas) and the
Missouri Department of Conservation.
NR 19
TC 0
Z9 0
U1 5
U2 9
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1535-1459
EI 1535-1467
J9 RIVER RES APPL
JI River Res. Appl.
PD MAY
PY 2016
VL 32
IS 4
BP 812
EP 819
DI 10.1002/rra.2901
PG 8
WC Environmental Sciences; Water Resources
SC Environmental Sciences & Ecology; Water Resources
GA DK1WE
UT WOS:000374704900027
ER
PT J
AU Uhl, ER
Camilletti, CR
Scullin, MH
Wood, JM
AF Uhl, Elizabeth R.
Camilletti, Catherine R.
Scullin, Matthew H.
Wood, James M.
TI Under Pressure: Individual Differences in Children's Suggestibility in
Response to Intense Social Influence
SO SOCIAL DEVELOPMENT
LA English
DT Article
DE suggestibility; social understanding; children; individual differences
ID INTERROGATIVE SUGGESTIBILITY; MEMORY; MIND; SUGGESTIONS
AB Prior research on the relation between children's suggestibility and verbal skills has yielded mixed results. This study examined children's suggestibility in a high social pressure context in conjunction with individual differences in verbal ability and social understanding. Sixty-nine children were read a story by a classroom visitor. One week later children were asked suggestive questions about the visit and pressured to respond yes'. One week after the first interview, children were re-asked the same questions, this time with no pressure. Children's suggestibility in response to social pressure was found to be significantly and negatively correlated with receptive vocabulary knowledge, but not with social understanding, the ability to understand and interpret social interactions. In addition, suggestibility scores exhibited a distinctly bimodal distribution, with many children acquiescing to all pressured suggestions, many children acquiescing to no suggestions, and few children falling between these two extremes.
C1 [Uhl, Elizabeth R.; Camilletti, Catherine R.; Scullin, Matthew H.; Wood, James M.] Univ Texas El Paso, El Paso, TX 79968 USA.
RP Uhl, ER (reprint author), US Army Res Inst, POB 52086, Ft Benning, GA 31995 USA.
EM elizabeth.r.uhl.civ@mail.mil
NR 23
TC 0
Z9 0
U1 4
U2 6
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0961-205X
EI 1467-9507
J9 SOC DEV
JI Soc. Dev.
PD MAY
PY 2016
VL 25
IS 2
BP 422
EP 434
DI 10.1111/sode.12156
PG 13
WC Psychology, Developmental
SC Psychology
GA DJ5PA
UT WOS:000374260300012
ER
PT J
AU Butkus, MA
Riegner, DE
Olind, J
AF Butkus, Michael A.
Riegner, Dawn E.
Olind, Johannes
TI Immobilization of lead by phosphate amended Polonite
SO CHEMOSPHERE
LA English
DT Article
DE Stabilization; Lead oxide; Pb4O(PO4)(2); Pozzolanic reaction products;
LDI-TOF
ID WASTE-WATER TREATMENT; X-RAY-ABSORPTION; SHOOTING-RANGE SOILS;
MASS-SPECTROMETRY; METAL REMOVAL; FILTER MEDIA; PHOSPHORUS;
HYDROXYAPATITES; ORTHOPHOSPHATES; SPECTROSCOPY
AB Polonite is an alkaline material that is used to remove nutrients from domestic wastewater and it has been evaluated as a fertilizer. Stabilization of Pb by Polonite and Polonite amended with orthophosphate, PO4, (Polonite-P) was studied. Octacalcium phosphate (Ca8H2(PO4)(6)center dot 5H(2)O) was a primary species of PO4 formed on the surface of Polonite-P. Lead was found to be associated with pozzolanic reaction products in Pb treated Polonite and Pb treated Polonite-P samples. Formation of Pb oxides, as precipitates or surface complexes, were substantial constituents of Pb treated Polonite. Dissolution of Ca8H2(PO4)(6).5H(2)O followed by formation of Pb4O(PO4)(2) was a probable mechanism of Pb removal by Polonite-P. Polonite-P could be a suitable replacement for current PO4 sources as a Pb stabilization agent. Finally, LDI-TOF was an effective technique for evaluating forms of Pb on Polonite and Polonite-P. Published by Elsevier Ltd.
C1 [Butkus, Michael A.; Olind, Johannes] US Mil Acad, Dept Geog & Environm Engn, Environm Engn Program, West Point, NY 10996 USA.
[Riegner, Dawn E.] US Mil Acad, Dept Chem & Life Sci, Chem Program, West Point, NY 10996 USA.
RP Butkus, MA (reprint author), US Mil Acad, Dept Geog & Environm Engn, Environm Engn Program, West Point, NY 10996 USA.
EM Michael.Butkus@usma.edu
FU U.S. Army Research Laboratory
FX The technical assistance of Mr. Anand Shetty, Mr. Mark Lennox, and Ms.
Taylor Pearce, Department of Geography and Environmental Engineering,
United States Military Academy is greatly appreciated. The technical
assistance of Christina Tricomi, Department of Chemistry and Life
Science, United States Military Academy is greatly appreciated. This
project was supported by a grant from the U.S. Army Research Laboratory.
Although the research presented in this paper has been undertaken by
personnel employed by US Military Academy, it does not necessarily
reflect the views of the Academy or the US Army.
NR 39
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U1 9
U2 18
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0045-6535
EI 1879-1298
J9 CHEMOSPHERE
JI Chemosphere
PD MAY
PY 2016
VL 151
BP 310
EP 317
DI 10.1016/j.chemosphere.2016.02.066
PG 8
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA DJ2YK
UT WOS:000374071000038
PM 26950021
ER
PT J
AU Schaefer, KE
Chen, JYC
Szalma, JL
Hancock, PA
AF Schaefer, Kristin E.
Chen, Jessie Y. C.
Szalma, James L.
Hancock, P. A.
TI A Meta-Analysis of Factors Influencing the Development of Trust in
Automation: Implications for Understanding Autonomy in Future Systems
SO HUMAN FACTORS
LA English
DT Review
DE human-automation interaction; human-robot interaction; meta-analysis;
trust
ID ADAPTIVE CRUISE CONTROL; HUMAN-FACTORS ISSUES; COLLISION WARNING
SYSTEMS; AIR-TRAFFIC MANAGEMENT; DRIVER TRUST; INDIVIDUAL-DIFFERENCES;
IMPERFECT AUTOMATION; SELF-CONFIDENCE; PERFORMANCE CONSEQUENCES; HUMAN
INTERVENTION
AB Objective: We used meta-analysis to assess research concerning human trust in automation to understand the foundation upon which future autonomous systems can be built.
Background: Trust is increasingly important in the growing need for synergistic human-machine teaming. Thus, we expand on our previous meta-analytic foundation in the field of human-robot interaction to include all of automation interaction.
Method: We used meta-analysis to assess trust in automation. Thirty studies provided 164 pairwise effect sizes, and 16 studies provided 63 correlational effect sizes.
Results: The overall effect size of all factors on trust development was (g) over bar = +0.48, and the correlational effect was = +0.34, each of which represented medium effects. Moderator effects were observed for the human-related ((g) over bar = +0.49;
(r) over bar = +0.16) and automation-related ((g) over bar = +0.53;
(r) over bar = +0.41) factors. Moderator effects specific to environmental factors proved insufficient in number to calculate at this time.
Conclusion: Findings provide a quantitative representation of factors influencing the development of trust in automation as well as identify additional areas of needed empirical research.
Application: This work has important implications to the enhancement of current and future human-automation interaction, especially in high-risk or extreme performance environments.
C1 [Schaefer, Kristin E.] US Army Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD USA.
[Chen, Jessie Y. C.] US Army Res Lab, Human Res & Engn Directorate, Orlando, FL USA.
[Szalma, James L.; Hancock, P. A.] Univ Cent Florida, Dept Psychol, Orlando, FL 32816 USA.
[Hancock, P. A.] Univ Cent Florida, Inst Simulat & Training, Orlando, FL 32816 USA.
RP Schaefer, KE (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD USA.
EM kristin.e.schaefer2.ctr@mail.mil
FU U.S. Army Research Laboratory [W911NF-10-2-0016, W911-NF-12-2-0019]
FX This research was sponsored by the U.S. Army Research Laboratory and was
accomplished under Cooperative Agreement Nos. W911NF-10-2-0016 and
W911-NF-12-2-0019. The views and conclusions contained in this document
are those of the authors and should not be interpreted as representing
the official policies, either expressed or implied, of the Army Research
Laboratory or the U.S. government. The U.S. government is authorized to
reproduce and distribute reprints for government purposes
notwithstanding any copyright notation herein. The authors would also
like to acknowledge the various research assistants and support staff
from the University of Central Florida who were associated with the
generation and submission of the document. We also acknowledge Susan
Hill, Donald Headley, and John F. Lockett III, U.S. Army Research
Laboratory, for their internal technical reviews and support as well as
our external technical reviewers.
NR 159
TC 3
Z9 3
U1 14
U2 29
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0018-7208
EI 1547-8181
J9 HUM FACTORS
JI Hum. Factors
PD MAY
PY 2016
VL 58
IS 3
BP 377
EP 400
DI 10.1177/0018720816634228
PG 24
WC Behavioral Sciences; Engineering, Industrial; Ergonomics; Psychology,
Applied; Psychology
SC Behavioral Sciences; Engineering; Psychology
GA DJ1HW
UT WOS:000373954900001
PM 27005902
ER
PT J
AU Mercado, JE
Rupp, MA
Chen, JYC
Barnes, MJ
Barber, D
Procci, K
AF Mercado, Joseph E.
Rupp, Michael A.
Chen, Jessie Y. C.
Barnes, Michael J.
Barber, Daniel
Procci, Katelyn
TI Intelligent Agent Transparency in Human-Agent Teaming for Multi-UxV
Management
SO HUMAN FACTORS
LA English
DT Article
DE intelligent agent transparency; human-agent teaming; multi-UxV
management
ID COMBAT IDENTIFICATION SYSTEM; SUPERVISORY CONTROL; WORKING-MEMORY;
EYE-MOVEMENTS; AUTOMATION; PERFORMANCE; RELIANCE; TRUST; ATTENTION;
AWARENESS
AB Objective: We investigated the effects of level of agent transparency on operator performance, trust, and workload in a context of human-agent teaming for multirobot management.
Background: Participants played the role of a heterogeneous unmanned vehicle (UxV) operator and were instructed to complete various missions by giving orders to UxVs through a computer interface. An intelligent agent (IA) assisted the participant by recommending two plansa top recommendation and a secondary recommendationfor every mission.
Method: A within-subjects design with three levels of agent transparency was employed in the present experiment. There were eight missions in each of three experimental blocks, grouped by level of transparency. During each experimental block, the IA was incorrect three out of eight times due to external information (e.g., commander's intent and intelligence). Operator performance, trust, workload, and usability data were collected.
Results: Results indicate that operator performance, trust, and perceived usability increased as a function of transparency level. Subjective and objective workload data indicate that participants' workload did not increase as a function of transparency. Furthermore, response time did not increase as a function of transparency.
Conclusion: Unlike previous research, which showed that increased transparency resulted in increased performance and trust calibration at the cost of greater workload and longer response time, our results support the benefits of transparency for performance effectiveness without additional costs.
Application: The current results will facilitate the implementation of IAs in military settings and will provide useful data to the design of heterogeneous UxV teams.
C1 [Mercado, Joseph E.] US Army Res Lab, Human Res & Engn Directorate, 340 Hulse Rd, Pensacola, FL 32508 USA.
[Rupp, Michael A.] Univ Cent Florida, Orlando, FL 32816 USA.
[Chen, Jessie Y. C.] US Army Res Lab, Human Res & Engn Directorate, Field Element, Orlando, FL 32508 USA.
[Barnes, Michael J.] US Army Res Lab, Orlando, FL 32508 USA.
[Barber, Daniel] Univ Cent Florida, Inst Simulat & Training, Orlando, FL 32816 USA.
[Procci, Katelyn] Univ Cent Florida, Orlando, FL 32816 USA.
RP Mercado, JE (reprint author), US Army Res Lab, Human Res & Engn Directorate, 340 Hulse Rd, Pensacola, FL 32508 USA.
EM joseph.mercado@med.navy.mil
FU Department of Defense Autonomy Research Pilot Initiative, under the
Intelligent Multi-UxV Planner With Adaptive Collaborative/Control
Technologies (IMPACT) project
FX This research was supported by the Department of Defense Autonomy
Research Pilot Initiative, under the Intelligent Multi-UxV Planner With
Adaptive Collaborative/Control Technologies (IMPACT) project. We wish to
thank Isacc Yi, Erica Valiente, Shan Lakhmani, and Jonathan Harris for
their contribution to this project. We would also like to thank Gloria
Calhoun and Mark Draper for their input.
NR 47
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U1 4
U2 10
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0018-7208
EI 1547-8181
J9 HUM FACTORS
JI Hum. Factors
PD MAY
PY 2016
VL 58
IS 3
BP 401
EP 415
DI 10.1177/0018720815621206
PG 15
WC Behavioral Sciences; Engineering, Industrial; Ergonomics; Psychology,
Applied; Psychology
SC Behavioral Sciences; Engineering; Psychology
GA DJ1HW
UT WOS:000373954900002
PM 26867556
ER
PT J
AU Dao, M
Nguyen, NH
Nasrabadi, NM
Tran, TD
AF Dao, Minh
Nguyen, Nam H.
Nasrabadi, Nasser M.
Tran, Trac D.
TI Collaborative Multi-Sensor Classification Via Sparsity-Based
Representation
SO IEEE TRANSACTIONS ON SIGNAL PROCESSING
LA English
DT Article
DE Multisensor; joint-sparse representation; groupsparse representation;
low-rank; kernel; classification
ID HYPERSPECTRAL IMAGE CLASSIFICATION; FACE RECOGNITION; DATA FUSION;
RECOVERY; REGRESSION; ALGORITHM
AB In this paper, we propose a general collaborative sparse representation framework for multi-sensor classification, which takes into account the correlations as well as complementary information between heterogeneous sensors simultaneously while considering joint sparsity within each sensor's observations. We also robustify our models to deal with the presence of sparse noise and low-rank interference signals. Specifically, we demonstrate that incorporating the noise or interference signal as a low-rank component in our models is essential in a multi-sensor classification problem when multiple co-located sources/sensors simultaneously record the same physical event. We further extend our frameworks to kernelized models which rely on sparsely representing a test sample in terms of all the training samples in a feature space induced by a kernel function. A fast and efficient algorithm based on alternative direction method is proposed where its convergence to an optimal solution is guaranteed. Extensive experiments are conducted on several real multi-sensor data sets and results are compared with the conventional classifiers to verify the effectiveness of the proposed methods.
C1 [Dao, Minh; Tran, Trac D.] Johns Hopkins Univ, Dept Elect & Comp Engn, Baltimore, MD 21218 USA.
[Nguyen, Nam H.] MIT, Dept Math, Cambridge, MA 02139 USA.
[Nasrabadi, Nasser M.] US Army Res Lab, Adelphi, MD 20783 USA.
RP Dao, M; Tran, TD (reprint author), Johns Hopkins Univ, Dept Elect & Comp Engn, Baltimore, MD 21218 USA.; Nguyen, NH (reprint author), MIT, Dept Math, Cambridge, MA 02139 USA.; Nasrabadi, NM (reprint author), US Army Res Lab, Adelphi, MD 20783 USA.
EM minh.dao@jhu.edu; namnguyen@math.mit.edu;
nasser.m.nasrabadi.civ@mail.mil; trac@jhu.edu
FU National Science Foundation [CCF-1117545, CCF-1422995]; Army Research
Office [60219-MA]; Office of Naval Research [N00014-12-1-0765]; Army
Research Laboratory SOAR Program
FX This work was supported in part by the National Science Foundation under
Grants CCF-1117545 and CCF-1422995, by the Army Research Office under
Grant 60219-MA, by the Office of Naval Research under Grant
N00014-12-1-0765, and by the Army Research Laboratory SOAR Program.
NR 47
TC 0
Z9 0
U1 7
U2 16
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1053-587X
EI 1941-0476
J9 IEEE T SIGNAL PROCES
JI IEEE Trans. Signal Process.
PD MAY 1
PY 2016
VL 64
IS 9
BP 2400
EP 2415
DI 10.1109/TSP.2016.2521605
PG 16
WC Engineering, Electrical & Electronic
SC Engineering
GA DJ1FA
UT WOS:000373947500018
ER
PT J
AU Jeong, HS
Layher, H
Cao, L
Vandergriff, T
Dominguez, AR
AF Jeong, Haneol S.
Layher, Heather
Cao, Lauren
Vandergriff, Travis
Dominguez, Arturo R.
TI Pyoderma gangrenosum (PG) associated with levamisole-adulterated
cocaine: Clinical, serologic, and histopathologic findings in a cohort
of patients
SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
LA English
DT Article
DE cocaine; dermatosis; immunologic markers; levamisole; pyoderma
gangrenosum
AB Background: Recently, isolated reports of pyoderma gangrenosum (PG) secondary to levamisole-contaminated cocaine have been described, with similar serologic findings to the vasculopathic presentation.
Objective: We sought to describe clinical, histopathological, and serologic findings in 8 patients with PG associated with levamisole-contaminated cocaine.
Methods: Eight consecutive patients presenting with this disease spanning the period from 2011 to 2015 were included for the cohort. Observed variables included: lesion distribution, morphology, serologic titers, and histopathologic evaluation for vasculitis and vasculopathy.
Results: All patients reported cocaine exposure prior to the onset of lesions resembling PG. Lesions appeared primarily on the upper (6 of 8 patients) and lower (all 8 patients) extremities. Most patients demonstrated elevated titers for p-ANCA and antiphospholipid antibodies, and a diffuse dermal infiltrate dominated by neutrophils was seen in all biopsy specimens. Lesions improved or remained stable with conservative management or short courses of steroids, and recurrence was only noted on re-exposure to adulterated cocaine.
Limitations: The study is limited by sample size.
Conclusions: PG may occur after exposure to levamisole-adulterated cocaine. Clinical and histopathological findings resemble those seen in conventional forms of PG, whereas serologic findings mirror those seen in other levamisole-associated vasculopathic or vasculitic eruptions. Cocaine avoidance represents a cornerstone of management in these patients.
C1 [Jeong, Haneol S.; Cao, Lauren; Vandergriff, Travis; Dominguez, Arturo R.] Univ Texas SW Med Ctr Dallas, Dept Dermatol, 5323 Harry Hines Blvd, Dallas, TX 75390 USA.
[Layher, Heather] Brooke Army Med Ctr, San Antonio Uniformed Serv Hlth Educ Consortium, Dermatol Residency Program, San Antonio, TX USA.
RP Dominguez, AR (reprint author), Univ Texas SW Med Ctr Dallas, Dept Dermatol, 5323 Harry Hines Blvd, Dallas, TX 75390 USA.
EM arturo.dominguez@utsouthwestern.edu
OI Dominguez, Arturo/0000-0001-8488-3194; Vandergriff,
Travis/0000-0001-6577-3838
NR 16
TC 0
Z9 0
U1 0
U2 1
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0190-9622
J9 J AM ACAD DERMATOL
JI J. Am. Acad. Dermatol.
PD MAY
PY 2016
VL 74
IS 5
BP 892
EP 898
DI 10.1016/j.jaad.2015.11.040
PG 7
WC Dermatology
SC Dermatology
GA DJ3PF
UT WOS:000374117100021
PM 26785804
ER
PT J
AU Zhao, BB
Duan, WY
Demirbilek, Z
Ertekin, RC
Webster, WC
AF Zhao, B. B.
Duan, W. Y.
Demirbilek, Z.
Ertekin, R. C.
Webster, W. C.
TI A comparative study between the IGN-2 equations and the fully nonlinear,
weakly dispersive Boussinesq equations
SO COASTAL ENGINEERING
LA English
DT Article
DE Irrotational Green-Naghdi equations; IGN-2 equations; Boussinesq
equations; Steady water waves; Nonlinear and weakly dispersive waves
ID GREEN-NAGHDI EQUATIONS; WATER-WAVES; SHALLOW; MODEL; DIFFRACTION; DEPTH
AB This work focuses on the comparison between the fully nonlinear, and weakly dispersive Boussinesq equations and the irrotational Green-Naghdi Level 2 (IGN-2) equations for incompressible and inviscid fluid and irrotational flow resulting from waves in finite water depth. We provide in this paper for the first time a comprehensive comparison of the GN/IGN and Boussinesq wave theories for strongly nonlinear and weakly dispersive waves. The Boussinesq approach results in many different theories depending on the different orders of approximation of nonlinearity and dispersion used in the corresponding perturbation series. The fully nonlinear, weakly dispersive Boussinesq equations have been widely used in problems involving coastal regions and harbors because it is more efficient than fully nonlinear, strongly dispersive Boussinesq equations. A competing theory is the strongly nonlinear IGN-2 wave theory. Since both sets of equations have comparable complexity, it is appropriate to compare the results of these equations with known numerically exact solutions to determine the advantages of each approach. In this study, we use the same iterative algorithm to obtain the steady solutions of the IGN-2 and Boussinesq equations for periodic waves. The steady solutions of the IGN-2 and Boussinesq equations are studied for four different wavelengths that cover a range of applicability of the theories. We show in this study that the Boussinesq equations give more accurate results for the velocity distribution at the wave-crest transection. The IGN-2 equations give more accurate results for the velocity distribution at the wave-trough transection. Moreover, it is shown that the IGN-2 equations give more accurate results on the wave speed and wave profile, and that they can treat accurately waves higher than the ones that the Boussinesq equations can treat. The calculations show that both of these sets of equations are very good for strongly nonlinear wave simulations and the limitations of each are different. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Zhao, B. B.; Duan, W. Y.; Ertekin, R. C.] Harbin Engn Univ, Coll Shipbldg Engn, Harbin 150001, Peoples R China.
[Demirbilek, Z.] US Army, Coastal & Hydraul Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Ertekin, R. C.] Univ Hawaii, Dept Ocean & Resources Engn, Honolulu, HI 96822 USA.
[Webster, W. C.] Univ Calif Berkeley, Civil & Environm Engn, Berkeley, CA 94720 USA.
RP Duan, WY (reprint author), Harbin Engn Univ, Coll Shipbldg Engn, Harbin 150001, Peoples R China.
EM duanwenyangheu@hotmail.com
FU National Natural Science Foundation of China [11572093, 51490671];
International Science and Technology Cooperation Project - National
Ministry of Science and Technology of China [2012DFA70420]; Special Fund
for Basic Scientific Research of Central Colleges (Harbin Engineering
University); High-Tech Ship Research Projects - Ministry of Industry and
Information Technology (MIIT) of P.R. China
FX The first and second authors' (BBZ and WYD) work is supported by the
National Natural Science Foundation of China (No. 11572093, 51490671),
International Science and Technology Cooperation Project sponsored by
National Ministry of Science and Technology of China (No. 2012DFA70420),
the Special Fund for Basic Scientific Research of Central Colleges
(Harbin Engineering University) and High-Tech Ship Research Projects
sponsored by the Ministry of Industry and Information Technology (MIIT)
of P.R. China.
NR 24
TC 0
Z9 0
U1 1
U2 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-3839
EI 1872-7379
J9 COAST ENG
JI Coast. Eng.
PD MAY
PY 2016
VL 111
BP 60
EP 69
DI 10.1016/j.coastaleng.2016.01.011
PG 10
WC Engineering, Civil; Engineering, Ocean
SC Engineering
GA DI5MZ
UT WOS:000373544600006
ER
PT J
AU Roth, MJ
Chen, JS
Slawson, TR
Danielson, KT
AF Roth, Michael J.
Chen, Jiun-Shyan
Slawson, Thomas R.
Danielson, Kent T.
TI Stable and flux-conserved meshfree formulation to model shocks
SO COMPUTATIONAL MECHANICS
LA English
DT Article
DE Meshfree; Shock; Gibbs phenomenon; Riemann-enriched stabilized
conforming nodal integration; Smoothed flux divergence
ID KERNEL PARTICLE METHODS; ESSENTIALLY NONOSCILLATORY SCHEMES; CONFORMING
NODAL INTEGRATION; REPRODUCING KERNEL; DIFFERENCE SCHEME; EULER
EQUATIONS; LAWS; ADAPTIVITY
AB Accurate shock modeling requires that two critical issues be addressed: (1) correct representation of the essential shock physics, and (2) control of Gibbs phenomenon oscillation at the discontinuity. In this work a stable (oscillation limiting) and flux-conserved formulation under the reproducing kernel particle method is developed for shock modeling. A smoothed flux divergence is constructed under the framework of stabilized conforming nodal integration, which is locally-enriched with a Riemann solution to satisfy the entropy production constraints. This Riemann-enriched flux divergence is embedded into the reproducing kernel formulation through a velocity correction that also provides oscillation control at the shock. The correction is constrained to the shock region by an automatic shock detection algorithm that is constructed using the intrinsic spectral decomposition feature of the reproducing kernel approximation. Several numerical examples are provided to verify accuracy of the proposed formulation.
C1 [Roth, Michael J.; Slawson, Thomas R.; Danielson, Kent T.] US Army Engineer Res & Dev Ctr, Vicksburg, MS USA.
[Chen, Jiun-Shyan] Univ Calif San Diego, Dept Struct Engn, San Diego, CA 92103 USA.
RP Chen, JS (reprint author), Univ Calif San Diego, Dept Struct Engn, San Diego, CA 92103 USA.
EM js-chen@ucsd.edu
NR 44
TC 0
Z9 0
U1 1
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0178-7675
EI 1432-0924
J9 COMPUT MECH
JI Comput. Mech.
PD MAY
PY 2016
VL 57
IS 5
BP 773
EP 792
DI 10.1007/s00466-016-1260-8
PG 20
WC Mathematics, Interdisciplinary Applications; Mechanics
SC Mathematics; Mechanics
GA DI7HH
UT WOS:000373669600005
ER
PT J
AU Burroughs, JE
Thomasson, JA
Marsella, R
Greiner, EC
Allan, SA
AF Burroughs, Jennifer E.
Thomasson, J. Alex
Marsella, Rosanna
Greiner, Ellis C.
Allan, Sandra A.
TI Ticks associated with domestic dogs and cats in Florida, USA
SO EXPERIMENTAL AND APPLIED ACAROLOGY
LA English
DT Article
DE Ticks; Dog; Cat; Rhipicephalus; Amblyomma; Ixodes; Florida
ID WHITE-TAILED DEER; CYTAUXZOON-FELIS; INFECTIOUS-DISEASES; BORNE
PATHOGENS; UNITED-STATES; IXODID TICKS; FERAL CATS; PREVALENCE; ACARI;
SEROPREVALENCE
AB Voluntary collections of ticks from domestic dogs and cats by veterinary practitioners across Florida, USA, were conducted over a 10 month period. Of the 1337 ticks submitted, five species of ixodid ticks were identified and included Rhipicephalus sanguineus, Amblyomma americanum, A. maculatum, Dermacentor variabilis, and Ixodes scapularis. Most ticks were collected from dogs (98.4 %) with the most predominant species being R. sanguineus (94.3 %). Of the ticks collected from cats (1.6 %), A. americanum were the most common (74 %). Only R. sanguineus were collected throughout the state, with the other species collected only in central and north Florida. The tick species collected from dogs and cats represent a risk to these domestic species as well as associated humans for a range of tick-borne diseases in Florida.
C1 [Burroughs, Jennifer E.; Greiner, Ellis C.] Univ Florida, Coll Vet Med, Dept Infect Dis & Pathol, Gainesville, FL 32607 USA.
[Thomasson, J. Alex] Merial Ltd, Field Vet Serv, Duluth, GA 30096 USA.
[Marsella, Rosanna] Univ Florida, Coll Vet Med, Dept Small Anim Clin Sci, Gainesville, FL 32607 USA.
[Allan, Sandra A.] USDA ARS, Ctr Med Agr & Vet Entomol, Gainesville, FL 32608 USA.
[Burroughs, Jennifer E.] US Army, Med Command, Carlisle, PA 17013 USA.
RP Allan, SA (reprint author), USDA ARS, Ctr Med Agr & Vet Entomol, Gainesville, FL 32608 USA.
EM sandy.allan@ars.usda.gov
NR 50
TC 1
Z9 1
U1 10
U2 21
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0168-8162
EI 1572-9702
J9 EXP APPL ACAROL
JI Exp. Appl. Acarol.
PD MAY
PY 2016
VL 69
IS 1
BP 87
EP 95
DI 10.1007/s10493-016-0019-4
PG 9
WC Entomology
SC Entomology
GA DI9YJ
UT WOS:000373858300008
PM 26888081
ER
PT J
AU Milanoi, S
Ongus, JR
Gachara, G
Coldren, R
Bulimo, W
AF Milanoi, Sylvia
Ongus, Juliette R.
Gachara, George
Coldren, Rodney
Bulimo, Wallace
TI Serotype and genetic diversity of human rhinovirus strains that
circulated in Kenya in 2008
SO INFLUENZA AND OTHER RESPIRATORY VIRUSES
LA English
DT Article
DE Diversity; genetic; Kenya; rhinovirus; serotype
ID RESPIRATORY-INFECTION; CHILDREN; PNEUMONIA; ILLNESSES; GENOTYPE; IMPACT;
JAPAN
AB BackgroundHuman rhinoviruses (HRVs) are a well-established cause of the common cold and recent studies indicated that they may be associated with severe acute respiratory illnesses (SARIs) like pneumonia, asthma, and bronchiolitis. Despite global studies on the genetic diversity of the virus, the serotype diversity of these viruses across diverse geographic regions in Kenya has not been characterized.
ObjectivesThis study sought to characterize the serotype diversity of HRV strains that circulated in Kenya in 2008.
MethodsA total of 517 archived nasopharyngeal samples collected in a previous respiratory virus surveillance program across Kenya in 2008 were selected. Participants enrolled were outpatients who presented with influenza-like (ILI) symptoms. Real-time RT-PCR was employed for preliminary HRV detection. HRV-positive samples were amplified using RT-PCR and thereafter the nucleotide sequences of the amplicons were determined followed by phylogenetic analysis.
ResultsTwenty-five percent of the samples tested positive for HRV. Phylogenetic analysis revealed that the Kenyan HRVs clustered into three main species comprising HRV-A (54%), HRV-B (12%), and HRV-C (35%). Overall, 20 different serotypes were identified. Intrastrain sequence homology among the Kenyan strains ranged from 58% to 100% at the nucleotide level and 55% to 100% at the amino acid level.
ConclusionThese results show that a wide range of HRV serotypes with different levels of nucleotide variation were present in Kenya. Furthermore, our data show that HRVs contributed substantially to influenza-like illness in Kenya in 2008.
C1 [Milanoi, Sylvia; Ongus, Juliette R.] JKUAT, Coll Hlth Sci COHES, Nairobi, Kenya.
[Gachara, George] Kenyatta Univ, Dept Med Lab Sci, Nairobi, Kenya.
[Coldren, Rodney; Bulimo, Wallace] US Med Res Directorate Kenya, DEID, Nairobi, Kenya.
[Coldren, Rodney; Bulimo, Wallace] Walter Reed Army Inst Res, Special Field Act, Silver Spring, MD USA.
[Bulimo, Wallace] Univ Nairobi, Dept Biochem, Nairobi, Kenya.
RP Bulimo, W (reprint author), POB 606-00621, Nairobi, Kenya.
EM Wallace.Bulimo@usamru-k.org
RI Bulimo, Wallace/B-1982-2014
OI Bulimo, Wallace/0000-0001-8475-0586
FU US Armed Forces Health Surveillance Center, Division of GEIS Operations
FX The authors thank the clinicians who collected the samples and the
patients from whom the samples were collected. Ms. Rachel Achilla is
acknowledged for laboratory management, Mr. Benjamin Opot and Mr.
Silvanos Opanda for nucleotide sequencing and analysis, respectively,
and Ms. Finnley Osuna and Meshack Wadegu for technical support and for
support of the director, KEMRI. Funding for this study was provided by
the US Armed Forces Health Surveillance Center, Division of GEIS
Operations. Disclaimer: The views expressed in this work are those of
the authors and do not represent those of the US Army Medical Research
Directorate-Kenya, Walter Reed Army Institute of Research, the US Army
Medical Department, the US Department of the Army, or US Department of
Defense.
NR 32
TC 0
Z9 0
U1 0
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1750-2640
EI 1750-2659
J9 INFLUENZA OTHER RESP
JI Influenza Other Respir. Viruses
PD MAY
PY 2016
VL 10
IS 3
BP 185
EP 191
DI 10.1111/irv.12373
PG 7
WC Infectious Diseases; Virology
SC Infectious Diseases; Virology
GA DI4SZ
UT WOS:000373490900006
PM 26822469
ER
PT J
AU Bravo, L
Wijeyakulasuriya, S
Pomraning, E
Senecal, PK
Kweon, CB
AF Bravo, Luis
Wijeyakulasuriya, Sameera
Pomraning, Eric
Senecal, Peter K.
Kweon, Chol-Bum
TI Large Eddy Simulation of High Reynolds Number Nonreacting and Reacting
JP-8 Sprays in a Constant Pressure Flow Vessel With a Detailed Chemistry
Approach
SO JOURNAL OF ENERGY RESOURCES TECHNOLOGY-TRANSACTIONS OF THE ASME
LA English
DT Article
ID IGNITION; MODEL; FUEL
AB In military propulsion applications, the characterization of internal combustion engines operating with jet fuel is vital to understand engine performance, combustion phasing, and emissions when JP-8 is fully substituted for diesel fuel. In this work, high-resolution large eddy simulation (LES) simulations have been performed in-order to provide a comprehensive analysis of the detailed mixture formation process in engine sprays for nozzle configurations of interest to the Army. The first phase examines the behavior of a non-reacting evaporating spray, and demonstrates the accuracy in predicting liquid and vapor transient penetration profiles using a multirealization statistical grid-converged approach. The study was conducted using a suite of single-orifice injectors ranging from 40 to 147 mu m at a rail pressure of 1000 bar and chamber conditions at 900K and 60 bar. The next phase models the nonpremixed combustion behavior of reacting sprays and investigates the submodel ability to predict auto-ignition and lift-off length (LOL) dynamics. The model is constructed using a Kelvin Helmholtz-Rayleigh Taylor (KH-RT) spray atomization framework coupled to an LES approach. The liquid physical properties are defined using a JP-8 mixture containing 80% n-decane and 20% trimethylbenzene (TMB), while the gas phase utilizes the Aachen kinetic mechanism (Hummer, et al., 2007, "Experimental and Kinetic Modeling Study of Combustion of JP-8, Its Surrogates, and Reference Components in Laminar Non Premixed Flows,"Proc. Combust. Inst., 31, pp. 393-400 and Honnet, et al., 2009, "A Surrogate Fuel for Kerosene," Proc. Combust. Inst., 32, pp. 485-492) and a detailed chemistry combustion approach. The results are in good agreement with the spray combustion measurements from the Army Research Laboratory (ARL), constant pressure flow (CPF) facility, and provide a robust computational framework for further JP-8 studies of spray combustion.
C1 [Bravo, Luis] US Army, Res Lab, Mem ASME, Vehicle Technol Directorate, 4603 Flare Loop Dr, Aberdeen Proving Ground, MD 21005 USA.
[Wijeyakulasuriya, Sameera; Pomraning, Eric; Senecal, Peter K.] Convergent Sci Inc, Mem ASME, 6400 Enterprise Ln, Madison, WI 53719 USA.
[Kweon, Chol-Bum] US Army, Res Lab, Vehicle Technol Directorate, 4603 Flare Loop Dr, Aberdeen Proving Ground, MD 21005 USA.
RP Bravo, L (reprint author), US Army, Res Lab, Mem ASME, Vehicle Technol Directorate, 4603 Flare Loop Dr, Aberdeen Proving Ground, MD 21005 USA.
EM luis.g.bravo2.civ@mail.mil; sameera.wijeyakulasuriya@convergecfd.com;
pomraning@convergecfd.com; senecal@convergecfd.com;
chol-bum.m.kweon2.civ@mail.mil
FU DoD High Performance Computing Modernization Program (HPCMP) FRONTIER
Award
FX This work was supported in part by resources from the DoD High
Performance Computing Modernization Program (HPCMP) FRONTIER Award. The
Army project is titled "Petascale High Fidelity Simulation of
Atomization and Spray/Wall Interactions at Diesel Engine Conditions."
NR 32
TC 0
Z9 0
U1 3
U2 8
PU ASME
PI NEW YORK
PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA
SN 0195-0738
J9 J ENERG RESOUR-ASME
JI J. Energy Resour. Technol.-Trans. ASME
PD MAY
PY 2016
VL 138
IS 3
AR 032207
DI 10.1115/1.4032901
PG 12
WC Energy & Fuels
SC Energy & Fuels
GA DI7UO
UT WOS:000373707700013
ER
PT J
AU Scenna, R
Gupta, AK
AF Scenna, Richard
Gupta, Ashwani K.
TI Preheats Effects on JP8 Reforming Under Volume Distributed Reaction
Conditions
SO JOURNAL OF ENERGY RESOURCES TECHNOLOGY-TRANSACTIONS OF THE ASME
LA English
DT Article
ID SOOT FORMATION; COMBUSTION; FUELS
AB Conventional noncatalytic fuel reforming provides low efficiency, large amounts of char and tar and limited control on chemical composition of the syngas produced. The distributed reaction regime can be used to assist noncatalytic reforming. In this paper, volume distributed reaction technique is used to enhance reformate quality as compared to conventional noncatalytic reforming. This work examines the intermediate regimes between volume distributed reaction and conventional flame to reform JP8 with focus on the chemical and mixing time scales. Chemical time scales were controlled with air preheat temperatures while the mixing time scales were kept constant. Progressive shift toward distributed reaction regime resulted in higher quality reformate with increased amounts of hydrogen and carbon monoxide in the syngas, but with reduced acetylene concentrations and soot formation. Visible soot formation was observed on reactor walls only under the flamelets in eddies regime. Higher hydrogen and carbon monoxide without any catalyst for JP8 reformation offers significant advantages on cost-effective plant operation, reliability, and high yields of syngas. Air preheats of 600, 630, and 660 degrees C showed a distributed reaction regime wherein the Damkohler number was below the Damkohler criterion, and this condition provided high H-2 and CO yields and no soot. At temperature of 690 degrees C, laminar flame thickness approximated the integral length scale (at the interface of distributed and traditional reforming flame) showed minor soot formation. At even higher temperature of 750 degrees C, conventional reforming occurred with increased soot observed.
C1 [Scenna, Richard] US Army, CERDEC CPI, Aberdeen Proving Ground, MD USA.
[Gupta, Ashwani K.] Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA.
RP Gupta, AK (reprint author), Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA.
EM akgupta@umd.edu
FU United States Army's Research Development Engineering Command
Independent Laboratory Innovative Research program
FX The authors acknowledge the support of United States Army's Research
Development Engineering Command Independent Laboratory Innovative
Research program. The authors also gratefully acknowledge the help and
support provided by Reaction Design for the Chemkin code used here. This
material is declared a work of the U.S. Government and is not subject to
copyright protection in the United States. Approved for public release;
distribution is unlimited.
NR 28
TC 0
Z9 0
U1 0
U2 0
PU ASME
PI NEW YORK
PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA
SN 0195-0738
J9 J ENERG RESOUR-ASME
JI J. Energy Resour. Technol.-Trans. ASME
PD MAY
PY 2016
VL 138
IS 3
AR 032202
DI 10.1115/1.4032140
PG 6
WC Energy & Fuels
SC Energy & Fuels
GA DI7UO
UT WOS:000373707700008
ER
PT J
AU Cordero, ZC
Carpenter, RR
Schuh, CA
Schuster, BE
AF Cordero, Zachary C.
Carpenter, Ryan R.
Schuh, Christopher A.
Schuster, Brian E.
TI Sub-scale ballistic testing of an ultrafine grained tungsten alloy into
concrete targets
SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING
LA English
DT Article
DE Ultrafine grained; Tungsten; Rigid body penetration; Concrete;
Penetrator materials
ID SPHERICAL CAVITY-EXPANSION; NOSE STEEL PROJECTILES; PENETRATION DEPTH;
DECELERATION; RODS
AB Ultrafine grained tungsten-based alloys are promising kinetic energy penetrator materials because of their high strengths and densities, making them ideal for penetration into concrete and geomaterials. However, there are difficulties in evaluating their ballistic performance using traditional testing techniques because ultrafine grain sizes are challenging to achieve in bulk parts. In this letter, we performed sub-scale ballistic experiments where ultrafine tungsten alloy cores were fired into concrete targets using small caliber projectile assemblies. The results suggest that sub-scale testing may be used as a screening tool for advanced kinetic energy penetrator materials that are more easily prepared in smaller geometries. Published by Elsevier Ltd.
C1 [Cordero, Zachary C.; Schuh, Christopher A.] MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA.
[Carpenter, Ryan R.] US Army, Armament Res Dev Engn Ctr, Picatinny Arsenal, NJ 07806 USA.
[Schuster, Brian E.] Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
RP Schuster, BE (reprint author), Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
EM brian.e.schuster.civ@mail.mil
FU U.S. Army Research Office through the Institute for Solider
Nanotechnologies at MIT [W911NF-14-1-0539]; US Defense Threat Reduction
Agency [HDTRA1-11-1-0062]; U.S. Department of Defense through the NDSEG
fellowship program
FX This work was supported by the U.S. Army Research Office under grant
W911NF-14-1-0539 and through the Institute for Solider Nanotechnologies
at MIT, and the US Defense Threat Reduction Agency under Grant No.
HDTRA1-11-1-0062. ZCC also acknowledges support from the U.S. Department
of Defense through the NDSEG fellowship program. The authors thank Dr.
Deepak Kapoor of the Picatinny Arsenal and Steven Livers formerly of
Boise State University for their assistance in preparing the ultrafine
grain tungsten rounds; Dr. Lee Magness of the Army Research Laboratory
for advising on the small-caliber testing geometry; and Prof. Emily
Huskins for performing high strain rate compression tests on the
ultrafine grain tungsten material.
NR 19
TC 0
Z9 0
U1 8
U2 17
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0734-743X
EI 1879-3509
J9 INT J IMPACT ENG
JI Int. J. Impact Eng.
PD MAY
PY 2016
VL 91
BP 1
EP 5
DI 10.1016/j.ijimpeng.2015.11.013
PG 5
WC Engineering, Mechanical; Mechanics
SC Engineering; Mechanics
GA DH3LY
UT WOS:000372689700001
ER
PT J
AU Sutcliffe, S
Nevin, RL
Pakpahan, R
Elliott, DJ
Langston, ME
De Marzo, AM
Gaydos, CA
Isaacs, WB
Nelson, WG
Sokoll, LJ
Walsh, PC
Zenilman, JM
Cersovsky, SB
Platz, EA
AF Sutcliffe, Siobhan
Nevin, Remington L.
Pakpahan, Ratna
Elliott, Debra J.
Langston, Marvin E.
De Marzo, Angelo M.
Gaydos, Charlotte A.
Isaacs, William B.
Nelson, William G.
Sokoll, Lori J.
Walsh, Patrick C.
Zenilman, Jonathan M.
Cersovsky, Steven B.
Platz, Elizabeth A.
TI Infectious mononucleosis, other infections and prostate-specific antigen
concentration as a marker of prostate involvement during infection
SO INTERNATIONAL JOURNAL OF CANCER
LA English
DT Article
DE infectious mononucleosis; infection; prostate-specific antigen; prostate
cancer; epidemiology
ID SEXUALLY-TRANSMITTED INFECTIONS; EPSTEIN-BARR-VIRUS; PSA CONCENTRATIONS;
LIVER-DISEASE; CANCER; SERUM; HEPATITIS; RISK; HYPERPLASIA; EXPRESSION
AB Although Epstein-Barr virus has been detected in prostate tissue, no associations have been observed with prostate cancer in the few studies conducted to date. One possible reason for these null findings may be use of cumulative exposure measures that do not inform the timing of infection, i.e., childhood versus adolescence/early adulthood when infection is more likely to manifest as infectious mononucleosis (IM). We sought to determine the influence of young adult-onset IM on the prostate by measuring prostate-specific antigen (PSA) as a marker of prostate inflammation/damage among U.S. military members. We defined IM cases as men diagnosed with IM from 1998 to 2003 (n=55) and controls as men without an IM diagnosis (n=255). We selected two archived serum specimens for each participant, the first collected after diagnosis for cases and one randomly selected from 1998 to 2003 for controls (index), as well as the preceding specimen (preindex). PSA was measured in each specimen. To explore the specificity of our findings for prostate as opposed to systemic inflammation, we performed a post hoc comparison of other infectious disease cases without genitourinary involvement (n=90) and controls (n=220). We found that IM cases were more likely to have a large PSA rise than controls (20 ng/mL: 19.7% versus 8.8%, p=0.027; 40% rise: 25.7% versus 9.4%, p=0.0021), as were other infectious disease cases (25.7% versus 14.0%, p=0.020; 27.7% versus 18.0%, p=0.092). These findings suggest that, in addition to rising because of prostate infection, PSA may also rise because of systemic inflammation, which could have implications for PSA interpretation in older men.
What's new? The discovery of Epstein-Barr virus (EBV) in neoplastic prostate tissue raises questions about the relevance of EBV infection in prostate cancer development. EBV is the major cause of infectious mononucleosis (IM), symptoms of which are most apparent in adolescents and young adults. This study of U.S. military members shows that young-adult (ages 18-25) onset IM is associated with a rise in prostate-specific antigen (PSA) levels during or following infection. Other systemic infections (e.g., influenza) were also linked to increases in PSA. The findings could have implications for the interpretation of PSA screening results.
C1 [Sutcliffe, Siobhan; Pakpahan, Ratna] Washington Univ, Sch Med, Dept Surg, Div Publ Hlth Sci, St Louis, MO 63110 USA.
[Sutcliffe, Siobhan] Washington Univ, Sch Med, Dept Surg, Alvin J Siteman Canc Ctr, St Louis, MO 63110 USA.
[Nevin, Remington L.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mental Hlth, Baltimore, MD USA.
[Elliott, Debra J.; De Marzo, Angelo M.; Nelson, William G.; Sokoll, Lori J.] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA.
[Langston, Marvin E.] Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Div Epidemiol & Biostat, Tucson, AZ USA.
[De Marzo, Angelo M.; Isaacs, William B.; Nelson, William G.; Sokoll, Lori J.; Walsh, Patrick C.; Platz, Elizabeth A.] Johns Hopkins Univ, Sch Med, Dept Urol, Baltimore, MD 21205 USA.
[De Marzo, Angelo M.; Isaacs, William B.; Nelson, William G.; Sokoll, Lori J.; Walsh, Patrick C.; Platz, Elizabeth A.] Johns Hopkins Univ, Sch Med, James Buchanan Brady Urol Inst, Baltimore, MD USA.
[De Marzo, Angelo M.; Isaacs, William B.; Nelson, William G.; Sokoll, Lori J.; Platz, Elizabeth A.] Sidney Kimmel Comprehens Canc Ctr Johns Hopkins, Baltimore, MD USA.
[Gaydos, Charlotte A.; Zenilman, Jonathan M.] Johns Hopkins Univ, Sch Med, Dept Med, Div Infect Dis, Baltimore, MD 21205 USA.
[Nelson, William G.] Johns Hopkins Univ, Sch Med, Dept Pharmacol, Baltimore, MD 21205 USA.
[Cersovsky, Steven B.] US Army, Publ Hlth Command Provis, Aberdeen, MD USA.
[Platz, Elizabeth A.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
RP Sutcliffe, S (reprint author), Washington Univ, Sch Med, Div Publ Hlth Sci, 600 S Taylor Ave,2nd Floor,Rm 208S,Box 8100, St Louis, MO 63110 USA.; Sutcliffe, S (reprint author), Washington Univ, Sch Med, Alvin J Siteman Canc Ctr, 600 S Taylor Ave,2nd Floor,Rm 208S,Box 8100, St Louis, MO 63110 USA.
EM sutcliffes@wudosis.wustl.edu
OI Nevin, Remington/0000-0002-0534-1889; Langston,
Marvin/0000-0002-4777-2425
FU Fund for Research and Progress in Urology, Johns Hopkins University
School of Medicine; Barnes-Jewish Hospital Foundation; Patrick C. Walsh
Prostate Cancer Research Fund; National Cancer Institute [P30 CA006973]
FX Grant sponsors: Fund for Research and Progress in Urology, Johns Hopkins
University School of Medicine; Barnes-Jewish Hospital Foundation;
Patrick C. Walsh Prostate Cancer Research Fund; Grant sponsor: National
Cancer Institute; Grant number: P30 CA006973
NR 49
TC 0
Z9 0
U1 0
U2 13
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0020-7136
EI 1097-0215
J9 INT J CANCER
JI Int. J. Cancer
PD MAY 1
PY 2016
VL 138
IS 9
BP 2221
EP 2230
DI 10.1002/ijc.29966
PG 10
WC Oncology
SC Oncology
GA DF2GY
UT WOS:000371161800017
PM 26678984
ER
PT J
AU Haynes, R
Cline, J
Shonkwiler, B
Armanios, E
AF Haynes, Robert
Cline, Julia
Shonkwiler, Brian
Armanios, Erian
TI On plane stress and plane strain in classical lamination theory
SO COMPOSITES SCIENCE AND TECHNOLOGY
LA English
DT Article
DE Mechanical properties; Elastic properties; Laminate theory
ID COMPOSITE-MATERIALS
AB Classical Lamination Theory combines the specially orthotropic nature of unidirectional composite plies with the assumptions of Kirchhoff plate theory to arrive at the in-plane properties of the laminate. Traditionally, the derivation assumes a plane stress state in each lamina prior to performing the rotational transformation from the lamina coordinates to the laminate coordinates, resulting in an incomplete formulation of the out-of-plane properties. In this work the rotational transformation of each lamina is performed prior to applying the plane stress or strain simplifications, resulting in an accurate formulation of the out-of-plane properties. Both plane stress and plane strain are considered. To illustrate the new formulation's ability to accurately predict out-of-plane properties, an optimization is performed to find laminates that exhibit the extrema of the out-of-plane Poisson's ratios. Verification of nearly optimal laminates with finite element analysis and experimental testing demonstrates improved accuracy of the new formulation. Published by Elsevier Ltd.
C1 [Haynes, Robert] US Army Res Lab, 4603 Flare Loop, Aberdeen Proving Ground, MD 21005 USA.
[Cline, Julia; Shonkwiler, Brian; Armanios, Erian] Univ Texas Arlington, Mech & Aerosp Engn, Box 19018, Arlington, TX 76079 USA.
RP Haynes, R (reprint author), US Army Res Lab, 4603 Flare Loop, Aberdeen Proving Ground, MD 21005 USA.
EM robert.a.haynes43.civ@mail.mil; julia.cline@uta.edu; shonkwil@uta.edu;
armanios@uta.edu
NR 23
TC 1
Z9 1
U1 2
U2 4
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0266-3538
EI 1879-1050
J9 COMPOS SCI TECHNOL
JI Compos. Sci. Technol.
PD APR 28
PY 2016
VL 127
BP 20
EP 27
DI 10.1016/j.compscitech.2016.02.010
PG 8
WC Materials Science, Composites
SC Materials Science
GA DK1XV
UT WOS:000374709700003
ER
PT J
AU Edmonds, J
Lindquist, HDA
Sabol, J
Martinez, K
Shadomy, S
Cymet, T
Emanuel, P
AF Edmonds, Jason
Lindquist, H. D. Alan
Sabol, Jonathan
Martinez, Kenneth
Shadomy, Sean
Cymet, Tyler
Emanuel, Peter
TI Multigeneration Cross-Contamination of Mail with Bacillus anthracis
Spores
SO PLOS ONE
LA English
DT Article
ID BIOTERRORISM-RELATED ANTHRAX; FATAL INHALATIONAL ANTHRAX; UNITED-STATES;
OUTBREAK; CONNECTICUT; WASHINGTON; DC
AB The release of biological agents, including those which could be used in biowarfare or bioterrorism in large urban areas, has been a concern for governments for nearly three decades. Previous incidents from Sverdlosk and the postal anthrax attack of 2001 have raised questions on the mechanism of spread of Bacillus anthracis spores as an aerosol or contaminant. Prior studies have demonstrated that Bacillus atrophaeus is easily transferred through simulated mail handing, but no reports have demonstrated this ability with Bacillus anthracis spores, which have morphological differences that may affect adhesion properties between spore and formite. In this study, equipment developed to simulate interactions across three generations of envelopes subjected to tumbling and mixing was used to evaluate the potential for cross-contamination of B. anthracis spores in simulated mail handling. In these experiments, we found that the potential for cross-contamination through letter tumbling from one generation to the next varied between generations while the presence of a fluidizer had no statistical impact on the transfer of material. Likewise, the presence or absence of a fluidizer had no statistically significant impact on cross-contamination levels or reaerosolization from letter opening.
C1 [Edmonds, Jason; Sabol, Jonathan; Emanuel, Peter] US Army, Dept Def, Edgewood Chem Biol Ctr, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA.
[Lindquist, H. D. Alan] US EPA, Off Res & Dev, Natl Homeland Secur Res Ctr, 26 West Martin Luther King Dr, Cincinnati, OH 45268 USA.
[Martinez, Kenneth] HWC Inc, 1100 New York Ave NW, Washington, DC 20005 USA.
[Shadomy, Sean] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, 1600 Clifton Rd,MS A-30, Atlanta, GA 30333 USA.
[Cymet, Tyler] Amer Assoc Coll Osteopath Med, Med Educ, Chevy Chase, MD 20815 USA.
RP Edmonds, J (reprint author), US Army, Dept Def, Edgewood Chem Biol Ctr, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA.
EM jason.m.edmonds2.civ@mail.mil
FU Combatting Terrorism Technical Support Working Group, Caution; Hassett
Willis; Department of Defense; Edgewood Chemical Biological Center;
Department of Health and Human Services Centers for Disease Control and
Prevention; National Institutes for Occupational Safety and Health;
Department of Justice; Federal Bureau of Investigations; U.S.
Environmental Protection Agency through its Office of Research and
Development
FX This program was partially funded by the Technical Support Working
Group, now the Combatting Terrorism Technical Support Working Group,
Caution (http://www.cttso.gov/). The funders had no role in study
design, data collection and analysis, decision to publish, or
preparation of the manuscript. Hassett Willis provided support in the
form of salaries for authors (KM), but did not have any additional role
in the study design, data collection and analysis, decision to publish,
or preparation of the manuscript. The Department of Defense, Edgewood
Chemical Biological Center, Department of Health and Human Services
Centers for Disease Control and Prevention, National Institutes for
Occupational Safety and Health, Department of Justice, Federal Bureau of
Investigations, and the U.S. Environmental Protection Agency through its
Office of Research and Development partially funded and collaborated in
the research described here. This manuscript has been subject to Agency
review and but does not necessarily reflect the views of the Agencies
listed above. The specific roles of these authors are articulated in the
author contributions section.; The Department of Defense, Edgewood
Chemical Biological Center, Department of Health and Human Services
Centers for Disease Control and Prevention, National Institutes for
Occupational Safety and Health, Department of Justice, Federal Bureau of
Investigations, and the U.S. Environmental Protection Agency through its
Office of Research and Development partially funded and collaborated in
the research described here. This manuscript has been subject to Agency
review and but does not necessarily reflect the views of the Agencies
listed above. No official endorsement should be inferred. Mention or use
of trade names does not constitute endorsement of recommendation for
use.
NR 25
TC 0
Z9 0
U1 3
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 28
PY 2016
VL 11
IS 4
AR e0152225
DI 10.1371/journal.pone.0152225
PG 13
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DK8XE
UT WOS:000375211700004
PM 27123934
ER
PT J
AU Agnandji, ST
Huttner, A
Zinser, ME
Njuguna, P
Dahlke, C
Fernandes, JF
Yerly, S
Dayer, JA
Kraehling, V
Kasonta, R
Adegnika, AA
Altfeld, M
Auderset, F
Bache, EB
Biedenkopf, N
Borregaard, S
Brosnahan, JS
Burrow, R
Combescure, C
Desmeules, J
Eickmann, M
Fehling, SK
Finckh, A
Goncalves, AR
Grobusch, MP
Hooper, J
Jambrecina, A
Kabwende, AL
Kaya, G
Kimani, D
Lell, B
Lemaitre, B
Lohse, AW
Massinga-Loembe, M
Matthey, A
Mordmuller, B
Nolting, A
Ogwang, C
Ramharter, M
Schmidt-Chanasit, J
Schmiedel, S
Silvera, P
Stahl, FR
Staines, HM
Strecker, T
Stubbe, HC
Tsofa, B
Zaki, S
Fast, P
Moorthy, V
Kaiser, L
Krishna, S
Becker, S
Kieny, MP
Bejon, P
Kremsner, PG
Addo, MM
Siegrist, CA
AF Agnandji, S. T.
Huttner, A.
Zinser, M. E.
Njuguna, P.
Dahlke, C.
Fernandes, J. F.
Yerly, S.
Dayer, J. -A.
Kraehling, V.
Kasonta, R.
Adegnika, A. A.
Altfeld, M.
Auderset, F.
Bache, E. B.
Biedenkopf, N.
Borregaard, S.
Brosnahan, J. S.
Burrow, R.
Combescure, C.
Desmeules, J.
Eickmann, M.
Fehling, S. K.
Finckh, A.
Goncalves, A. R.
Grobusch, M. P.
Hooper, J.
Jambrecina, A.
Kabwende, A. L.
Kaya, G.
Kimani, D.
Lell, B.
Lemaitre, B.
Lohse, A. W.
Massinga-Loembe, M.
Matthey, A.
Mordmueller, B.
Nolting, A.
Ogwang, C.
Ramharter, M.
Schmidt-Chanasit, J.
Schmiedel, S.
Silvera, P.
Stahl, F. R.
Staines, H. M.
Strecker, T.
Stubbe, H. C.
Tsofa, B.
Zaki, S.
Fast, P.
Moorthy, V.
Kaiser, L.
Krishna, S.
Becker, S.
Kieny, M. -P.
Bejon, P.
Kremsner, P. G.
Addo, M. M.
Siegrist, C. -A.
TI Phase 1 Trials of rVSV Ebola Vaccine in Africa and Europe
SO NEW ENGLAND JOURNAL OF MEDICINE
LA English
DT Article
ID VESICULAR STOMATITIS-VIRUS; PROTECTS NONHUMAN-PRIMATES; MARBURG VIRUS;
INFECTION; IMMUNITY; VSV
AB BACKGROUND
The replication-competent recombinant vesicular stomatitis virus (rVSV)-based vaccine expressing a Zaire ebolavirus (ZEBOV) glycoprotein was selected for rapid safety and immunogenicity testing before its use in West Africa.
METHODS
We performed three open-label, dose-escalation phase 1 trials and one randomized, double-blind, controlled phase 1 trial to assess the safety, side-effect profile, and immunogenicity of rVSV-ZEBOV at various doses in 158 healthy adults in Europe and Africa. All participants were injected with doses of vaccine ranging from 300,000 to 50 million plaque-forming units (PFU) or placebo.
RESULTS
No serious vaccine-related adverse events were reported. Mild-to-moderate early-onset reactogenicity was frequent but transient (median, 1 day). Fever was observed in up to 30% of vaccinees. Vaccine viremia was detected within 3 days in 123 of the 130 participants (95%) receiving 3 million PFU or more; rVSV was not detected in saliva or urine. In the second week after injection, arthritis affecting one to four joints developed in 11 of 51 participants (22%) in Geneva, with pain lasting a median of 8 days (interquartile range, 4 to 87); 2 self-limited cases occurred in 60 participants (3%) in Hamburg, Germany, and Kilifi, Kenya. The virus was identified in one synovial-fluid aspirate and in skin vesicles of 2 other vaccinees, showing peripheral viral replication in the second week after immunization. ZEBOV-glycoprotein-specific antibody responses were detected in all the participants, with similar glycoprotein-binding antibody titers but significantly higher neutralizing antibody titers at higher doses. Glyco-protein-binding antibody titers were sustained through 180 days in all participants.
CONCLUSIONS
In these studies, rVSV-ZEBOV was reactogenic but immunogenic after a single dose and warrants further evaluation for safety and efficacy.
C1 [Siegrist, C. -A.] Univ Hosp Geneva, Ctr Vaccinol, 1 Rue Michel Servet, CH-1211 Geneva 4, Switzerland.
[Agnandji, S. T.; Fernandes, J. F.; Adegnika, A. A.; Bache, E. B.; Brosnahan, J. S.; Grobusch, M. P.; Kabwende, A. L.; Lell, B.; Massinga-Loembe, M.; Mordmueller, B.; Ramharter, M.; Krishna, S.; Kremsner, P. G.] Ctr Rech Med Lambarene, Lambarene, Gabon.
[Agnandji, S. T.; Fernandes, J. F.; Adegnika, A. A.; Bache, E. B.; Brosnahan, J. S.; Grobusch, M. P.; Kabwende, A. L.; Lell, B.; Massinga-Loembe, M.; Mordmueller, B.; Ramharter, M.; Krishna, S.; Kremsner, P. G.] Univ Klinikum Tubinen, Inst Tropenmed, Tubingen, Germany.
[Agnandji, S. T.; Fernandes, J. F.; Adegnika, A. A.; Bache, E. B.; Brosnahan, J. S.; Grobusch, M. P.; Kabwende, A. L.; Lell, B.; Massinga-Loembe, M.; Mordmueller, B.; Ramharter, M.; Krishna, S.; Kremsner, P. G.] German Ctr Infect Res, Tubingen, Germany.
[Zinser, M. E.; Dahlke, C.; Kasonta, R.; Lohse, A. W.; Nolting, A.; Schmiedel, S.; Stubbe, H. C.; Addo, M. M.] Univ Med Ctr Hamburg Eppendorf, Dept Med 1, Hamburg, Germany.
[Stahl, F. R.] Inst Clin Chem & Lab Med, Hamburg, Germany.
[Dahlke, C.; Nolting, A.; Schmidt-Chanasit, J.; Stubbe, H. C.; Addo, M. M.] German Ctr Infect Res, Partner Site Standort Hamburg lUBECK Borstel, Hamburg, Germany.
[Altfeld, M.] Leibniz Inst Expt Virol, Heinrich Pette Inst, Hamburg, Germany.
[Borregaard, S.; Jambrecina, A.] Clin Trial Ctr North, Hamburg, Germany.
[Schmidt-Chanasit, J.] WHO, Collaborating Ctr Arbovirus & Hemorrhag Fever Ref, Natl Reference Ctr Trop Infect Dis, Bernhard Nocht Inst Trop Med, Hamburg, Germany.
[Kraehling, V.; Biedenkopf, N.; Eickmann, M.; Fehling, S. K.; Strecker, T.; Becker, S.] Univ Marburg, Inst Virol, Partner Site Giessen Marburg Langen, D-35032 Marburg, Germany.
[Kraehling, V.; Biedenkopf, N.; Eickmann, M.; Fehling, S. K.; Strecker, T.; Becker, S.] German Ctr Infect Res DZIF, Partner Site Giessen Marburg Langen, Marburg, Germany.
[Kasonta, R.] Paul Ehrlich Inst, Div Vet Med, Langen, Germany.
[Huttner, A.] Univ Hosp Geneva, Infect Control Program, CH-1211 Geneva 4, Switzerland.
[Huttner, A.; Dayer, J. -A.; Kaiser, L.] Univ Hosp Geneva, Div Infect Dis, CH-1211 Geneva 4, Switzerland.
[Combescure, C.] Univ Hosp Geneva, Div Clin Epidemiol, CH-1211 Geneva 4, Switzerland.
[Finckh, A.] Univ Hosp Geneva, Div Rheumatol, CH-1211 Geneva 4, Switzerland.
[Kaya, G.] Univ Hosp Geneva, Div Dermatol, CH-1211 Geneva 4, Switzerland.
[Desmeules, J.; Matthey, A.] Univ Hosp Geneva, Clin Res Ctr, CH-1211 Geneva 4, Switzerland.
[Yerly, S.; Goncalves, A. R.; Kaiser, L.] Univ Hosp Geneva, Fac Med, CH-1211 Geneva 4, Switzerland.
[Yerly, S.; Goncalves, A. R.; Kaiser, L.] Univ Hosp Geneva, Virol Lab, CH-1211 Geneva 4, Switzerland.
[Auderset, F.; Lemaitre, B.; Siegrist, C. -A.] WHO, Collaborat Ctr Vaccinol, Fac Med, Geneva, Switzerland.
[Fast, P.; Moorthy, V.; Kieny, M. -P.] WHO, Geneva, Switzerland.
[Njuguna, P.; Kimani, D.; Ogwang, C.; Tsofa, B.; Bejon, P.] Ctr Geog Med Res, Kenya Med Res Inst, Wellcome Trust Res Program, Kilifi, Kenya.
[Adegnika, A. A.] Leiden Univ, Dept Parasitol, Med Ctr, Leiden, Netherlands.
[Grobusch, M. P.] Univ Amsterdam, Acad Med Ctr, Ctr Trop Med & Travel Med, Dept Infect Dis,Div Internal Med, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
[Burrow, R.; Staines, H. M.; Krishna, S.] Univ London, Inst Infect & Immun, London WC1E 7HU, England.
[Hooper, J.; Silvera, P.] US Army, Dept Mol Virol, Med Res Inst Infect, Frederick, MD USA.
[Hooper, J.; Silvera, P.] US Army, Div Translat Sci, Med Res Inst Infect, Frederick, MD USA.
[Ramharter, M.] Med Univ Vienna, Dept Med 1, Div Infect Dis & Trop Med, Vienna, Austria.
[Zaki, S.] Ctr Dis Control & Prevent, Infect Dis Pathol Branch, Atlanta, GA USA.
[Fast, P.] Int AIDS Vaccine Initiat, New York, NY USA.
RP Addo, MM (reprint author), Univ Med Ctr Hamburg Eppendorf, Dept Med 1, Div Trop Med, Martinistr 52, D-20246 Hamburg, Germany.; Siegrist, CA (reprint author), Univ Hosp Geneva, Ctr Vaccinol, 1 Rue Michel Servet, CH-1211 Geneva 4, Switzerland.; Siegrist, CA (reprint author), Ctr Med Univ Geneva, Fac Med, 1 Rue Michel Servet, CH-1211 Geneva 4, Switzerland.
EM m.addo@uke.de; claire-anne.siegrist@unige.ch
RI Staines, Henry/B-6281-2009; Ramharter, Michael/C-5273-2013
OI Staines, Henry/0000-0001-5890-3040; Ramharter,
Michael/0000-0002-9259-1885
FU Wellcome Trust
FX Funded by the Wellcome Trust and others; ClinicalTrials.gov numbers,
NCT02283099, NCT02287480, and NCT02296983; Pan African Clinical Trials
Registry number, PACTR201411000919191.
NR 32
TC 61
Z9 62
U1 21
U2 44
PU MASSACHUSETTS MEDICAL SOC
PI WALTHAM
PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA
SN 0028-4793
EI 1533-4406
J9 NEW ENGL J MED
JI N. Engl. J. Med.
PD APR 28
PY 2016
VL 374
IS 17
BP 1647
EP 1660
DI 10.1056/NEJMoa1502924
PG 14
WC Medicine, General & Internal
SC General & Internal Medicine
GA DK3UR
UT WOS:000374843400008
PM 25830326
ER
PT J
AU Timmerwilke, J
Liou, SH
Cheng, SF
Edelstein, AS
AF Timmerwilke, John
Liou, Sy-Hwang
Cheng, Shu Fan
Edelstein, Alan S.
TI Rewriting magnetic phase change memory by laser heating
SO JOURNAL OF PHYSICS D-APPLIED PHYSICS
LA English
DT Article
DE memory; phase change; magnetic
ID THIN-FILMS; CRYSTALLIZATION
AB Magnetic phase change memory (MAG PCM) consists of bits with different magnetic permeability values. The bits are read by measuring their effect on a magnetic probe field. Previously low permeability crystalline bits had been written in high permeability amorphous films of Metglas via laser heating. Here data is presented showing that by applying short laser pulses with the appropriate power to previously crystallized regions they can first be vitrified and then again crystallized. Thus, MAG PCM is rewriteable. Technical issues in processing the bits are discussed and results on thermal modeling are presented.
C1 [Timmerwilke, John; Edelstein, Alan S.] US Army Res Lab, Adelphi, MD 20783 USA.
[Liou, Sy-Hwang] Univ Nebraska, Dept Phys & Astron, Lincoln, NE 68588 USA.
[Cheng, Shu Fan] Naval Res Lab, Washington, DC 20375 USA.
RP Timmerwilke, J (reprint author), US Army Res Lab, Adelphi, MD 20783 USA.
NR 17
TC 0
Z9 0
U1 4
U2 9
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0022-3727
EI 1361-6463
J9 J PHYS D APPL PHYS
JI J. Phys. D-Appl. Phys.
PD APR 27
PY 2016
VL 49
IS 16
AR 165005
DI 10.1088/0022-3727/49/16/165005
PG 6
WC Physics, Applied
SC Physics
GA DI6PV
UT WOS:000373622900006
ER
PT J
AU Govindarajan, V
Rakesh, V
Reifman, J
Mitrophanov, AY
AF Govindarajan, Vijay
Rakesh, Vineet
Reifman, Jaques
Mitrophanov, Alexander Y.
TI Computational Study of Thrombus Formation and Clotting Factor Effects
under Venous Flow Conditions
SO BIOPHYSICAL JOURNAL
LA English
DT Article
ID PROTHROMBIN COMPLEX CONCENTRATE; SURFACE-MEDIATED CONTROL;
BLOOD-COAGULATION; PLATELET DEPOSITION; TISSUE FACTOR; FIBRINOGEN
CONCENTRATE; IN-VIVO; HYDRAULIC PERMEABILITY; INTRALUMINAL THROMBUS;
MULTISCALE MODEL
AB A comprehensive understanding of thrombus formation as a physicochemical process that has evolved to protect the integrity of the human vasculature is critical to our ability to predict and control pathological states caused by a malfunctioning blood coagulation system. Despite numerous investigations, the spatial and temporal details of thrombus growth as a multicomponent process are not fully understood. Here, we used computational modeling to investigate the temporal changes in the spatial distributions of the key enzymatic (i.e., thrombin) and structural (i.e., platelets and fibrin) components within a growing thrombus. Moreover, we investigated the interplay between clot structure and its mechanical properties, such as hydraulic resistance to flow. Our model relied on the coupling of computational fluid dynamics and biochemical kinetics, and was validated using flow-chamber data from a previous experimental study. The model allowed us to identify the distinct patterns characterizing the spatial distributions of thrombin, platelets, and fibrin accumulating within a thrombus. Our modeling results suggested that under the simulated conditions, thrombin kinetics was determined predominantly by prothrombinase. Furthermore, our simulations showed that thrombus resistance imparted by fibrin was similar to 30-fold higher than that imparted by platelets. Yet, thrombus-mediated bloodflow occlusion was driven primarily by the platelet deposition process, because the height of the platelet accumulation domain was approximately twice that of the fibrin accumulation domain. Fibrinogen supplementation in normal blood resulted in a nonlinear increase in thrombus resistance, and for a supplemented fibrinogen level of 48%, the thrombus resistance increased by similar to 2.7-fold. Finally, our model predicted that restoring the normal levels of clotting factors II, IX, and X while simultaneously restoring fibrinogen (to 88% of its normal level) in diluted blood can restore fibrin generation to similar to 78% of its normal level and hence improve clot formation under dilution.
C1 [Govindarajan, Vijay; Rakesh, Vineet; Reifman, Jaques; Mitrophanov, Alexander Y.] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Biotechnol High Performance Comp Software Applica, Dept Def, Ft Detrick, MD USA.
RP Reifman, J (reprint author), US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Biotechnol High Performance Comp Software Applica, Dept Def, Ft Detrick, MD USA.
EM jaques.reifman.civ@mail.mil
FU U.S. Army Network Science Initiative, U.S. Army Medical Research and
Materiel Command, Fort Detrick, MD
FX This work was supported by the U.S. Army Network Science Initiative,
U.S. Army Medical Research and Materiel Command, Fort Detrick, MD.
High-performance computing resources were made available by the U.S.
Department of Defense High Performance Computing Modernization Program.
NR 97
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U1 2
U2 5
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0006-3495
EI 1542-0086
J9 BIOPHYS J
JI Biophys. J.
PD APR 26
PY 2016
VL 110
IS 8
BP 1869
EP 1885
DI 10.1016/j.bpj.2016.03.010
PG 17
WC Biophysics
SC Biophysics
GA DK4AV
UT WOS:000374859600020
PM 27119646
ER
PT J
AU Wang, YW
Im, JS
Soares, JW
Steeves, DM
Whitten, JE
AF Wang, Yiwen
Im, Jisun
Soares, Jason W.
Steeves, Diane M.
Whitten, James E.
TI Thiol Adsorption on and Reduction of Copper Oxide Particles and Surfaces
SO LANGMUIR
LA English
DT Article
ID SELF-ASSEMBLED MONOLAYERS; SENSITIZED SOLAR-CELLS; METAL-OXIDES;
ELECTRONIC-PROPERTIES; CORROSION INHIBITION; OXIDATION; CU2O;
ALKANETHIOLS; CU(111); OXYGEN
AB The adsorption of 1-dodecanethiol at room temperature and at 75 degrees C on submicron cuprous and cupric oxide particles suspended in ethanol has been investigated by X-ray photoelectron spectroscopy (XPS), Raman spectroscopy, and transmission electron microscopy. Thiol adsorption occurs in all cases via Cu-S bond formation, with partial dissolution of CuO at 75 degrees C and formation of a copper thiolate complex replacement layer. Regardless of temperature, the surface of the CuO particles is essentially completely reduced to either Cu2O or metallic copper, as evidenced by loss of the characteristic Cu2+ XPS features of dried powder samples. Companion ultrahigh-vacuum studies have been performed by dosing clean, oxygen-dosed, and ozone-treated single crystal Cu(111) with methanethiol (MT) gas at room temperature. In the latter case, the surface corresponds to CuO/Cu(111). XPS confirms MT adsorption in all cases, with an S 2p peak binding energy of 162.9 +/- 0.1 eV, consistent with methanethiolate adsorption. Heating of MT-covered Cu(111) and oxygen-dosed Cu(111) leads to decomposition/desorption of the MT by 100 degrees C and formation of copper sulfide with an S 2p binding energy of 161.8 eV. Dosing CuO/Cu(111) with 50-200 L of MT leads to only partial reduction/removal of the CuO surface layers prior to methanethiolate adsorption. This is confirmed by ultraviolet photoelectron spectroscopy (UPS), which measures the occupied states near the Fermi level. For both the colloidal CuO and single crystal CuO/Cu(111) studies, the reduction of the Cu2+ surface is believed to occur by formation and desorption of the corresponding dithiol prior to thiolate adsorption.
C1 [Wang, Yiwen; Im, Jisun; Whitten, James E.] Univ Massachusetts, Dept Chem, Lowell, MA 01854 USA.
[Soares, Jason W.; Steeves, Diane M.] US Army, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA.
RP Whitten, JE (reprint author), Univ Massachusetts, Dept Chem, Lowell, MA 01854 USA.
EM James_Whitten@uml.edu
FU U.S. Army Natick Soldier Research, Development, and Engineering Center
[W911QY-13-2-003]
FX The authors acknowledge the assistance of Dr. Peng Wang at Bruker Optics
in obtaining the Raman spectra. This work is supported by U.S. Army
Natick Soldier Research, Development, and Engineering Center, under
Cooperative Agreement #W911QY-13-2-003. The authors also acknowledge an
equipment donation of the ozone generator from MKS, Inc.
NR 38
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U2 36
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0743-7463
J9 LANGMUIR
JI Langmuir
PD APR 26
PY 2016
VL 32
IS 16
BP 3848
EP 3857
DI 10.1021/acs.langmuir.6b00651
PG 10
WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science,
Multidisciplinary
SC Chemistry; Materials Science
GA DK9IE
UT WOS:000375243300006
PM 27036074
ER
PT J
AU Torrisi, SB
Britton, JW
Bohnet, JG
Bollinger, JJ
AF Torrisi, Steven B.
Britton, Joseph W.
Bohnet, Justin G.
Bollinger, John J.
TI Perpendicular laser cooling with a rotating-wall potential in a Penning
trap
SO PHYSICAL REVIEW A
LA English
DT Article
ID NONNEUTRAL PLASMAS; ION PLASMAS; CRYSTALS
AB We investigate the impact of a rotating-wall potential on perpendicular laser cooling in a Penning ion trap. By including energy exchange with the rotating wall, we extend previous Doppler laser-cooling theory and show that low perpendicular temperatures are more readily achieved with a rotating wall than without. Detailed numerical studies determine optimal operating parameters for producing low-temperature, stable two-dimensional crystals, important for quantum information processing experiments employing Penning traps.
C1 [Torrisi, Steven B.; Britton, Joseph W.; Bohnet, Justin G.; Bollinger, John J.] NIST, Boulder, CO 80305 USA.
[Torrisi, Steven B.] Univ Rochester, Dept Phys & Astron, Rochester, NY 14627 USA.
[Britton, Joseph W.] US Army Res Lab, Adelphi, MD 20783 USA.
RP Torrisi, SB (reprint author), NIST, Boulder, CO 80305 USA.; Torrisi, SB (reprint author), Univ Rochester, Dept Phys & Astron, Rochester, NY 14627 USA.
FU Summer Undergraduate Research Fellowship through NIST; NIST NRC
postdoctoral fellowship
FX We acknowledge useful discussions with D. H. E. Dubin, R. C. Thompson,
A. Keith, and D. Meiser. We thank K. Gilmore and R. Fox for their
comments on the manuscript. S.B.T. was supported by Summer Undergraduate
Research Fellowship funding through NIST. J.G.B. was supported by a NIST
NRC postdoctoral fellowship. This manuscript is a contribution of NIST
and not subject to U.S. copyright.
NR 25
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Z9 1
U1 4
U2 4
PU AMER PHYSICAL SOC
PI COLLEGE PK
PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA
SN 2469-9926
EI 2469-9934
J9 PHYS REV A
JI Phys. Rev. A
PD APR 26
PY 2016
VL 93
IS 4
AR 043421
DI 10.1103/PhysRevA.93.043421
PG 8
WC Optics; Physics, Atomic, Molecular & Chemical
SC Optics; Physics
GA DK4ZJ
UT WOS:000374928600012
ER
PT J
AU Ingersoll, T
Cole, S
Madren-Whalley, J
Booker, L
Dorsey, R
Li, A
Salem, H
AF Ingersoll, Thomas
Cole, Stephanie
Madren-Whalley, Janna
Booker, Lamont
Dorsey, Russell
Li, Albert
Salem, Harry
TI Generalized Additive Mixed-Models for Pharmacology Using Integrated
Discrete Multiple Organ Co-Culture
SO PLOS ONE
LA English
DT Article
ID CYTOTOXIC METABOLITES; LINEAR-MODELS; CYCLOPHOSPHAMIDE; INSECTICIDES;
HEPATOCYTES; MOUSE
AB Integrated Discrete Multiple Organ Co-culture (IDMOC) is emerging as an in-vitro alternative to in-vivo animal models for pharmacology studies. IDMOC allows dose-response relationships to be investigated at the tissue and organoid levels, yet, these relationships often exhibit responses that are far more complex than the binary responses often measured in whole animals. To accommodate departure from binary endpoints, IDMOC requires an expansion of analytic techniques beyond simple linear probit and logistic models familiar in toxicology. IDMOC dose-responses may be measured at continuous scales, exhibit significant non-linearity such as local maxima or minima, and may include non-independent measures. Generalized additive mixed-modeling (GAMM) provides an alternative description of dose-response that relaxes assumptions of independence and linearity. We compared GAMMs to traditional linear models for describing dose-response in IDMOC pharmacology studies.
C1 [Ingersoll, Thomas] Def Threat Reduct Agcy, Joint CBRN Ctr Excellence, Aberdeen Proving Ground, MD USA.
[Cole, Stephanie; Madren-Whalley, Janna; Dorsey, Russell; Salem, Harry] US Army Res Dev & Engn Command, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA.
[Booker, Lamont] US FDA, Silver Spring, MD USA.
[Li, Albert] In Vitro ADMET Labs, Columbia, MD USA.
RP Ingersoll, T (reprint author), Def Threat Reduct Agcy, Joint CBRN Ctr Excellence, Aberdeen Proving Ground, MD USA.
EM thomas.e.ingersoll.civ@mail.mil
FU ADMET Laboratories; Defense Threat Reduction Agency; US Army Research,
Development, and Engineering Command; National Research Council,
Research Associate Program
FX The authors received no specific funding for this work, other than
support in the form of authors' salaries. One co-author (AL) is employed
by a commercial company: ADMET Laboratories. This does not alter the
authors' adherence to PLOS ONE policies on sharing data and materials.
ADMET Laboratories provided support in the form of salary for co-author
AL, but did not have any additional role in the study design, data
collection and analysis, decision to publish, or preparation of the
manuscript. The specific roles of these authors are articulated in the
'author contributions' section.; The authors would like to thank the
Defense Threat Reduction Agency, the US Army Research, Development, and
Engineering Command, and the National Research Council, Research
Associate Program for sponsoring this research.
NR 27
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U1 2
U2 6
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 25
PY 2016
VL 11
IS 4
AR e0152985
DI 10.1371/journal.pone.0152985
PG 12
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DK5OX
UT WOS:000374970600008
PM 27110941
ER
PT J
AU DeMar, J
Sharrow, K
Hill, M
Berman, J
Oliver, T
Long, J
AF DeMar, James
Sharrow, Keith
Hill, Miya
Berman, Jonathan
Oliver, Thomas
Long, Joseph
TI Effects of Primary Blast Overpressure on Retina and Optic Tract in Rats
SO FRONTIERS IN NEUROLOGY
LA English
DT Article
DE blast; neurotrauma; retina; optic tract; rat
ID TRAUMATIC BRAIN-INJURY; INDUCED OCULAR TRAUMA; MOUSE MODEL; AFGHANISTAN
WARS; DEGENERATION; TBI; DAMAGE; EYE; PATHOPHYSIOLOGY; MECHANISMS
AB Blast has been the leading cause of injury, particularly traumatic brain injury and visual system injury, in combat operations in Iraq and Afghanistan. We determined the effect of shock tube-generated primary blast on retinal electrophysiology and on retinal and brain optic tract histopathology in a rat model. The amplitude of a- and b-waves on the electroretinogram (ERG) for both right and left eyes were measured prior to a battlefield simulation Friedlander-type blast wave and on 1, 7, and 14 days thereafter. Histopathologic findings of the right and left retina and the right and left optic tracts (2.8 mm postoptic chiasm) were evaluated 14 days after the blast. For two experiments in which the right eye was oriented to the blast, the amplitude of ERG a- and b-waves at 7 days post blast on the right side but not on the left side was diminished compared to that of sham animals (P = 0.005-0.01) Histopathologic injury scores at 14 days post blast for the right retina but not the left retina were higher than for sham animals (P = 0.01), and histopathologic injury scores at 14 days for both optic tracts were markedly higher than for shams (P < 0.0001). Exposure of one eye to a blast wave, comparable to that causing human injury, produced injury to the retina as determined by ERG and histopathology, and to both postchiasmatic optic tracts as determined by histopathology. This model may be useful for analyzing the effect of therapeutic interventions on retinal damage due to primary blast waves.
C1 [DeMar, James; Hill, Miya; Long, Joseph] Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA.
[Sharrow, Keith] Med Countermeasures Syst, Frederick, MD USA.
[Berman, Jonathan] Walter Reed Army Inst Res, Dept Clin Pharmacol, Silver Spring, MD USA.
[Oliver, Thomas] Uniformed Serv Univ Hlth Sci, Clin Res Unit, Bethesda, MD 20814 USA.
RP DeMar, J (reprint author), Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA.
EM james.c.demar.ctr@mail.mil
FU USAMRMC/TATRC Vision Research Program [W81XWH-12-2-0082]
FX This work was supported in part by a USAMRMC/TATRC Vision Research
Program grant award, #: W81XWH-12-2-0082.
NR 32
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U1 7
U2 7
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015,
SWITZERLAND
SN 1664-2295
J9 FRONT NEUROL
JI Front. Neurol.
PD APR 25
PY 2016
VL 7
AR 59
DI 10.3389/fneur.2016.00059
PG 12
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA DK0WV
UT WOS:000374633800001
PM 27199884
ER
PT J
AU Dye, JM
Wu, H
Hooper, JW
Khurana, S
Kuehne, AI
Coyle, EM
Ortiz, RA
Fuentes, S
Herbert, AS
Golding, H
Bakken, RA
Brannan, JM
Kwilas, SA
Sullivan, EJ
Luke, TC
Smith, G
Glenn, G
Li, WF
Ye, L
Yang, CL
Compans, RW
Tripp, RA
Jiao, JA
AF Dye, John M.
Wu, Hua
Hooper, Jay W.
Khurana, Surender
Kuehne, Ana I.
Coyle, Elizabeth M.
Ortiz, Ramon A.
Fuentes, Sandra
Herbert, Andrew S.
Golding, Hana
Bakken, Russell A.
Brannan, Jennifer M.
Kwilas, Steve A.
Sullivan, Eddie J.
Luke, Thomas C.
Smith, Gale
Glenn, Gregory
Li, Wenfang
Ye, Ling
Yang, Chinglai
Compans, Richard W.
Tripp, Ralph A.
Jiao, Jin-an
TI Production of Potent Fully Human Polyclonal Antibodies against Ebola
Zaire Virus in Transchromosomal Cattle
SO SCIENTIFIC REPORTS
LA English
DT Article
ID HEMORRHAGIC-FEVER; NONHUMAN-PRIMATES; INFECTION; PROPHYLAXIS;
PROTECTION; DISEASE; ZMAPP
AB Polyclonal antibodies, derived from humans or hyperimmunized animals, have been used prophylactically or therapeutically as countermeasures for a variety of infectious diseases. SAB Biotherapeutics has successfully developed a transchromosomic (Tc) bovine platform technology that can produce fully human immunoglobulins rapidly, and in substantial quantities, against a variety of disease targets. In this study, two Tc bovines expressing high levels of fully human IgG were hyperimmunized with a recombinant glycoprotein (GP) vaccine consisting of the 2014 Ebola virus (EBOV) Makona isolate. Serum collected from these hyperimmunized Tc bovines contained high titers of human IgG against EBOV GP as determined by GP specific ELISA, surface plasmon resonance (SPR), and virus neutralization assays. Fully human polyclonal antibodies against EBOV were purified and evaluated in a mouse challenge model using mouse adapted Ebola virus (maEBOV). Intraperitoneal administration of the purified anti-EBOV IgG (100 mg/kg) to BALB/c mice one day after lethal challenge with maEBOV resulted in 90% protection; whereas 100% of the control animals succumbed. The results show that hyperimmunization of Tc bovines with EBOV GP can elicit protective and potent neutralizing fully human IgG antibodies rapidly and in commercially viable quantities.
C1 [Dye, John M.; Kuehne, Ana I.; Ortiz, Ramon A.; Herbert, Andrew S.; Bakken, Russell A.; Brannan, Jennifer M.; Kwilas, Steve A.] US Army Med Res Inst Infect Dis, Virol Div, Ft Detrick, MD USA.
[Wu, Hua; Sullivan, Eddie J.; Jiao, Jin-an] SAB Biotherapeut, Sioux Falls, SD USA.
[Khurana, Surender; Coyle, Elizabeth M.; Fuentes, Sandra; Golding, Hana] US FDA, Div Viral Prod, CBER, Silver Spring, MD USA.
[Luke, Thomas C.] Henry Jackson Fdn, Viral & Rickettsial Dis Dept, Navy Med Res Ctr, Silver Spring, MD USA.
[Smith, Gale; Glenn, Gregory] Novavax Inc, Gaithersburg, MD USA.
[Li, Wenfang; Ye, Ling; Yang, Chinglai; Compans, Richard W.] Emory Univ, Dept Microbiol & Immunol, Atlanta, GA 30322 USA.
[Li, Wenfang; Ye, Ling; Yang, Chinglai; Compans, Richard W.] Emory Univ, Emory Vaccine Ctr, Atlanta, GA 30322 USA.
[Tripp, Ralph A.] Univ Georgia, Athens, GA 30602 USA.
RP Jiao, JA (reprint author), SAB Biotherapeut, Sioux Falls, SD USA.
EM jjiao@sabbiotherapeutics.com
OI Hooper, Jay/0000-0002-4475-0415
FU SAB Biotherapeutics, Inc; Novavax, Inc.; Viral and Rickettsial Diseases
Department of the Naval Medical Research Center (VRDD, NMRC); Henry
Jackson Foundation for the Advancement of Military Medicine; US Navy
[Omnibus III DO-0005]
FX This work was funded in part by SAB Biotherapeutics, Inc and Novavax,
Inc. Financial interest in this work is currently owned by SAB
Biotherapeutics, Inc, and Novavax, Inc. who did have a role in the
decision to publish as well as the preparation of the manuscript. While
it is considered beneficial to the interests of SAB Biotherapeutics, Inc
and Novavax, Inc. to publish this work, this consideration played no
role in the study design, data collection and analysis and preparation
of the manuscript. This project was supported in part by the Viral and
Rickettsial Diseases Department of the Naval Medical Research Center
(VRDD, NMRC) and The Henry Jackson Foundation for the Advancement of
Military Medicine contract with the US Navy (Contract # Omnibus III
DO-0005). The views expressed in this article are those of the authors
and do not necessarily reflect the official policy or position of the
Department of the U.S. Army or Navy, or Department of Defense. Some of
the authors are employees of the U.S. Government, and this work was
prepared as part of their official duties.
NR 32
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U1 3
U2 5
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD APR 25
PY 2016
VL 6
AR 24897
DI 10.1038/srep24897
PG 9
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DK1EM
UT WOS:000374655300001
PM 27109916
ER
PT J
AU Ananworanich, J
Melvin, D
Amador, JTR
Childs, T
Medin, G
Boscolo, V
Compagnucci, A
Kanjanavanit, S
Montero, S
Gibb, DM
AF Ananworanich, Jintanat
Melvin, Diane
Amador, Jose T. R.
Childs, Tristan
Medin, Gabriela
Boscolo, Valentina
Compagnucci, Alexandra
Kanjanavanit, Suparat
Montero, Samuel
Gibb, Diana M.
CA PENTA 11 Study Grp
TI Neurocognition and quality of life after reinitiating antiretroviral
therapy in children randomized to planned treatment interruption
SO AIDS
LA English
DT Article
DE antiretroviral therapy; neurodevelopment; treatment interruption; HIV;
quality of life; neurocognition; children
ID HIV-INFECTED CHILDREN; PERINATALLY ACQUIRED HIV; NEURODEVELOPMENTAL
OUTCOMES; YOUNG-CHILDREN; ADOLESCENCE; CHILDHOOD; INFANTS; REMISSION;
SEVERITY; PREDICT
AB Objective:
Understanding the effects of antiretroviral treatment (ART) interruption on neurocognition and quality of life (QoL) are important for managing unplanned interruptions and planned interruptions in HIV cure research.
Design:
Children previously randomized to continuous (continuous ART, n = 41) vs. planned treatment interruption (PTI, n = 47) in the Pediatric European Network for Treatment of AIDS (PENTA) 11 study were enrolled. At study end, PTI children resumed ART. At 1 and 2 years following study end, children were assessed by the coding, symbol search and digit span subtests of Wechsler Intelligence Scale for Children (6-16 years old) or Wechsler Adult Intelligence Scale (>= 17 years old) and by Pediatrics QoL questionnaires for physical and psychological QoL. Transformed scaled scores for neurocognition and mean standardized scores for QoL were compared between arms by t-test and Mann-Whitney U test, respectively. Scores indicating clinical concern were compared (<7 for neurocognition and <70 for QoL tests).
Results:
Characteristics were similar between arms with a median age of 12.6 years, CD4(+) of 830 cells/mu l and HIV RNA of 1.7 log(10)copies/ml. The median cumulative ART exposure was 9.6 in continuous ART vs. 7.7 years in PTI (P = 0.02). PTI children had a median of 12 months off ART and had resumed ART for 25.2 months at time of first assessment. Neurocognitive scores were similar between arms for all tests. Physical and psychological QoL scores were no different. About 40% had low neurocognitive and QoL scores indicating clinical concern.
Conclusion:
No differences in information processing speed, sustained attention, short-term memory and QoL functioning were observed between children previously randomized to continuous ART vs. PTI in the PENTA 11 trial.
C1 [Ananworanich, Jintanat] Thai Red Cross AIDS Res Ctr, HIV Netherlands Australia Thailand Res Collaborat, Bangkok, Thailand.
[Melvin, Diane] Imperial Coll Healthcare NHS Trust, London, England.
[Amador, Jose T. R.; Medin, Gabriela] Hosp Clin San Carlos, Madrid, Spain.
[Childs, Tristan; Montero, Samuel; Gibb, Diana M.] UCL, Inst Clin Trials & Methodol, MRC Clin Trials Unit, London, England.
[Boscolo, Valentina] Univ Padua, Pediat Clin, Padua, Italy.
[Compagnucci, Alexandra] Inserm ANRS, SC10 US19, Villejuif, France.
[Kanjanavanit, Suparat] Nakornping Hosp, Chiang Mai, Thailand.
RP Ananworanich, J (reprint author), Henry M Jackson Fdn Adv Mil Med, Walter Reed Army Inst Res, US Mil HIV Res Program, Bethesda, MD USA.
EM jananworanich@hivresearch.org
OI Nunez Cuadros, Esmeralda/0000-0003-1938-1678
FU European Commission/European Union [260694, LSHP-CT-2006018865,
QLK2-CT-2000-00150]; PENTA Foundation
FX Sources of support: PENTA is a coordinated action of the European
Commission/European Union, supported by the seventh framework programme
(FP7/2007-2013) under the Eurocoord grant agreement number 260694, the
sixth framework contract number LSHP-CT-2006018865, the fifth framework
programme contract number QLK2-CT-2000-00150, and by the PENTA
Foundation.
NR 31
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U1 3
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0269-9370
EI 1473-5571
J9 AIDS
JI Aids
PD APR 24
PY 2016
VL 30
IS 7
BP 1075
EP 1081
DI 10.1097/QAD.0000000000001011
PG 7
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA DI1BA
UT WOS:000373229800002
PM 26730569
ER
PT J
AU Sliozberg, YR
Kroger, M
Chantawansri, TL
AF Sliozberg, Yelena R.
Kroger, Martin
Chantawansri, Tanya L.
TI Fast equilibration protocol for million atom systems of highly entangled
linear polyethylene chains
SO JOURNAL OF CHEMICAL PHYSICS
LA English
DT Article
ID MONTE-CARLO-SIMULATION; MOLECULAR-DYNAMICS SIMULATIONS; POLYMER MELTS;
SEMICRYSTALLINE POLYETHYLENE; MECHANICAL-PROPERTIES; DEFORMATION;
ALGORITHM; NANOFIBERS; LENGTH; MODEL
AB Equilibrated systems of entangled polymer melts cannot be produced using direct brute force equilibration due to the slow reptation dynamics exhibited by high molecular weight chains. Instead, these dense systems are produced using computational techniques such as Monte Carlo-Molecular Dynamics hybrid algorithms, though the use of soft potentials has also shown promise mainly for coarse-grained polymeric systems. Through the use of soft-potentials, the melt can be equilibrated via molecular dynamics at intermediate and long length scales prior to switching to a Lennard-Jones potential. We will outline two different equilibration protocols, which use various degrees of information to produce the starting configurations. In one protocol, we use only the equilibrium bond angle, bond length, and target density during the construction of the simulation cell, where the information is obtained from available experimental data and extracted from the force field without performing any prior simulation. In the second protocol, we moreover utilize the equilibrium radial distribution function and dihedral angle distribution. This information can be obtained from experimental data or from a simulation of short unentangled chains. Both methods can be used to prepare equilibrated and highly entangled systems, but the second protocol is much more computationally efficient. These systems can be strictly monodisperse or optionally polydisperse depending on the starting chain distribution. Our protocols, which utilize a soft-core harmonic potential, will be applied for the first time to equilibrate a million particle system of polyethylene chains consisting of 1000 united atoms at various temperatures. Calculations of structural and entanglement properties demonstrate that this method can be used as an alternative towards the generation of entangled equilibrium structures. Published by AIP Publishing.
C1 [Sliozberg, Yelena R.; Chantawansri, Tanya L.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Sliozberg, Yelena R.] TKC Global Inc, Aberdeen Proving Ground, MD 21005 USA.
[Kroger, Martin] ETH, Dept Mat, Polymer Phys, Leopold Ruzicka Weg 4, CH-8093 Zurich, Switzerland.
RP Sliozberg, YR (reprint author), US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA.; Sliozberg, YR (reprint author), TKC Global Inc, Aberdeen Proving Ground, MD 21005 USA.
RI Kroger, Martin/C-1946-2008
OI Kroger, Martin/0000-0003-1402-6714
FU U.S. Army Research Laboratory [W911-QX-14-C0016]; Swiss National Science
Foundation [SNF 200021_156106]
FX The authors would like to thank Professors Jay Schieber, Mark Robbins,
Mr. Thomas O'Connor, and Dr. Jan Andzelm and Dr. Robert Elder for useful
discussion. Calculations were performed using the DOD Supercomputing
Resource Center located at the Air Force and Navy Laboratories. The
research reported in this document was performed in connection with
Contract/Instrument No. W911-QX-14-C0016 with the U.S. Army Research
Laboratory. The views and conclusions contained in this document are
those of TKC Global, Inc. and the U.S. Army Research Laboratory.
Citation of manufacturer's or trade names does not constitute an
official endorsement or approval of the use thereof. The U.S. Government
is authorized to reproduce and distribute reprints for Government
purposes notwithstanding any copyright notation hereon. M.K. would like
to acknowledge support by the Swiss National Science Foundation through
Grant No. SNF 200021_156106.
NR 51
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U1 3
U2 10
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0021-9606
EI 1089-7690
J9 J CHEM PHYS
JI J. Chem. Phys.
PD APR 21
PY 2016
VL 144
IS 15
AR 154901
DI 10.1063/1.4946802
PG 12
WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical
SC Chemistry; Physics
GA DL6YM
UT WOS:000375786000038
PM 27389234
ER
PT J
AU Duy, J
Koehler, JW
Honko, AN
Schoepp, RJ
Wauquier, N
Gonzalez, JP
Pitt, ML
Mucker, EM
Johnson, JC
O'Hearn, A
Bangura, J
Coomber, M
Minogue, TD
AF Duy, Janice
Koehler, Jeffrey W.
Honko, Anna N.
Schoepp, Randal J.
Wauquier, Nadia
Gonzalez, Jean-Paul
Pitt, M. Louise
Mucker, Eric M.
Johnson, Joshua C.
O'Hearn, Aileen
Bangura, James
Coomber, Moinya
Minogue, Timothy D.
TI Circulating microRNA profiles of Ebola virus infection
SO SCIENTIFIC REPORTS
LA English
DT Article
ID ZAIRE EBOLAVIRUS; SIERRA-LEONE; DISEASE; CLASSIFICATION; EXPRESSION;
SUPPORT; CANCER; TIME; GLYCOPROTEIN; TRANSMISSION
AB Early detection of Ebola virus (EBOV) infection is essential to halting transmission and adjudicating appropriate treatment. However, current methods rely on viral identification, and this approach can misdiagnose presymptomatic and asymptomatic individuals. In contrast, disease-driven alterations in the host transcriptome can be exploited for pathogen-specific diagnostic biomarkers. Here, we present for the first time EBOV-induced changes in circulating miRNA populations of nonhuman primates (NHPs) and humans. We retrospectively profiled longitudinally-collected plasma samples from rhesus macaques challenged via intramuscular and aerosol routes and found 36 miRNAs differentially present in both groups. Comparison of miRNA abundances to viral loads uncovered 15 highly correlated miRNAs common to EBOV-infected NHPs and humans. As proof of principle, we developed an eight-miRNA classifier that correctly categorized infection status in 64/74 (86%) human and NHP samples. The classifier identified acute infections in 27/29 (93.1%) samples and in 6/12 (50%) presymptomatic NHPs. These findings showed applicability of NHP-derived miRNAs to a human cohort, and with additional research the resulting classifiers could impact the current capability to diagnose presymptomatic and asymptomatic EBOV infections.
C1 [Duy, Janice; Koehler, Jeffrey W.; Schoepp, Randal J.; O'Hearn, Aileen; Minogue, Timothy D.] US Army, Med Res Inst Infect Dis, Diagnost Syst Div, Frederick, MD USA.
[Honko, Anna N.; Pitt, M. Louise; Mucker, Eric M.; Johnson, Joshua C.] US Army, Med Res Inst Infect Dis, Div Virol, Frederick, MD 21701 USA.
[Wauquier, Nadia; Bangura, James; Coomber, Moinya] Metabiota, Kenema, Sierra Leone.
[Gonzalez, Jean-Paul] Metabiota, Washington, DC USA.
[Honko, Anna N.; Johnson, Joshua C.] NIAID, Integrated Res Facil, NIH, Frederick, MD USA.
RP Minogue, TD (reprint author), US Army, Med Res Inst Infect Dis, Diagnost Syst Div, Frederick, MD USA.
EM timothy.d.minogue.civ@mail.mil
OI Honko, Anna/0000-0001-9165-148X; Koehler, Jeffrey/0000-0003-3225-6599
FU Defense Threat Reduction Agency award [CB3630]
FX The authors would like to thank the members of the Virology Division,
Pathology Division and the Center for Aerobiological Sciences at
USAMRIID for study support. Specifically, we would like to thank the
following for their assistance: Heather Esham, Joshua Shamblin, Ginger
Donnelly, Nancy Twenhafel, Dave Dyer and Steve Orr. We would also like
to thank Dr. Christopher Stefan for his assistance. Funding for this
work was provided through Defense Threat Reduction Agency award #CB3630
( awarded to Timothy D. Minogue and Jeffrey W. Koehler). The funders had
no role in study design, data collection and interpretation, or the
decision to submit the work for publication.
NR 69
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PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD APR 21
PY 2016
VL 6
AR 24496
DI 10.1038/srep24496
PG 13
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DJ8SR
UT WOS:000374483800001
PM 27098369
ER
PT J
AU Kiziltas, A
Nazari, B
Kiziltas, EE
Gardner, DJ
Han, Y
Rushing, TS
AF Kiziltas, Alper
Nazari, Behzad
Kiziltas, Esra Erbas
Gardner, Douglas J.
Han, Yousoo
Rushing, Todd S.
TI Method to reinforce polylactic acid with cellulose nanofibers via a
polyhydroxybutyrate carrier system
SO CARBOHYDRATE POLYMERS
LA English
DT Article
DE Cellulose nanofibers (CNF); Polylactic acid (PLA); Rheology;
Polyhydroxybutyrate (PHB); Morphology
ID NYLON 6 COMPOSITES; SURFACE-MODIFICATION; BIODEGRADABLE POLYMERS;
MECHANICAL-PROPERTIES; PHYSICAL-PROPERTIES; PLA COMPOSITES;
NANOCOMPOSITES; BLENDS; NANOWHISKERS; DISPERSION
AB The elastic moduli of PLA reinforced with 5 and 10 wt.% CNF with the carrier, at a frequency (co) of 0.07, were 67% and 415% higher, respectively, than that of neat PLA. The shear viscosity at a shear rate of 0.01 (eta(0.01)) for PLA + 10 wt.% CNF was 32% higher than that of the neat PLA matrix. The eta(0.01) of PLA reinforced with 5 wt.% CNF and the PHB carrier was similar to neat PLA. The tensile and flexural moduli of elasticity of the nanocomposites continuously increased with increased CNF loading. The results of the mechanical property measurements are in accordance with the rheological data. The CNF appeared to be better dispersed (less-aggregated nanofibers) in the PLA reinforced with 5 wt.% CNF and the PHB carrier. Possible applications for the composites studied in this research are packaging materials, construction materials, and auto parts for interior applications. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Kiziltas, Alper; Gardner, Douglas J.; Han, Yousoo] Univ Maine, Adv Struct & Composites Ctr AEWC, Orono, ME 04469 USA.
[Kiziltas, Alper] Univ Bartin, Fac Forestry, Dept Forest Ind Engn, TR-74100 Bartin, Turkey.
[Nazari, Behzad] Univ Maine, Dept Chem Engn, Orono, ME 04469 USA.
[Kiziltas, Esra Erbas] Sci & Technol Res Council Turkey TUBITAK, TR-06100 Ankara, Turkey.
[Rushing, Todd S.] US Army Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
RP Kiziltas, A (reprint author), Univ Maine, Adv Struct & Composites Ctr AEWC, Orono, ME 04469 USA.
EM kiziltasalper@gmail.com
FU U.S. Army Engineer Research and Development Center project
[912HZ-07-2-0013]; Maine Agricultural and Forest Experiment Station
(MAFES) project [ME09615-08MS]
FX Funding was provided by the U.S. Army Engineer Research and Development
Center project 912HZ-07-2-0013 and the Maine Agricultural and Forest
Experiment Station (MAFES) project ME09615-08MS.
NR 51
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U2 57
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0144-8617
EI 1879-1344
J9 CARBOHYD POLYM
JI Carbohydr. Polym.
PD APR 20
PY 2016
VL 140
BP 393
EP 399
DI 10.1016/j.carbpol.2015.12.059
PG 7
WC Chemistry, Applied; Chemistry, Organic; Polymer Science
SC Chemistry; Polymer Science
GA DD5JA
UT WOS:000369958300047
PM 26876866
ER
PT J
AU Fasinu, PS
Avula, B
Tekwani, BL
Nanayakkara, NPD
Wang, YH
Herath, HMTB
McChesney, JD
Reichard, GA
Marcsisin, SR
Elsohly, MA
Khan, SI
Khan, IA
Walker, LA
AF Fasinu, Pius S.
Avula, Bharathi
Tekwani, Babu L.
Nanayakkara, N. P. Dhammika
Wang, Yan-Hong
Herath, H. M. T. Bandara
McChesney, James D.
Reichard, Gregory A.
Marcsisin, Sean R.
Elsohly, Mahmoud A.
Khan, Shabana I.
Khan, Ikhlas A.
Walker, Larry A.
TI Differential kinetic profiles and metabolism of primaquine enantiomers
by human hepatocytes
SO MALARIA JOURNAL
LA English
DT Article
DE Enantioselectivity; Hepatocytes; Malaria; Metabolism; Primaquine
enantiomers; Primaquine metabolites
ID ANTIMALARIAL-DRUG PRIMAQUINE; HUMAN-ERYTHROCYTES; VIVAX MALARIA;
IN-VITRO; CYP 2D6; PHARMACOKINETICS; IDENTIFICATION
AB Background: The clinical utility of primaquine (PQ), used as a racemic mixture of two enantiomers, is limited due to metabolism-linked hemolytic toxicity in individuals with genetic deficiency in glucose-6-phosphate dehydrogenase. The current study investigated differential metabolism of PQ enantiomers in light of the suggestions that toxicity and efficacy might be largely enantioselective.
Methods: Stable isotope C-13-labelled primaquine and its two enantiomers (+)-PQ, (-)-PQ were separately incubated with cryopreserved human hepatocytes. Time-tracked substrate depletion and metabolite production were monitored via UHPLC-MS/MS.
Results: The initial half-life of 217 and 65 min; elimination rate constants (lambda) of 0.19 and 0.64 h(-1); intrinsic clearance (Cl-int) of 2.55 and 8.49 (mu L/min)/million cells, which when up-scaled yielded Cl-int of 6.49 and 21.6 (mL/min)/kg body mass was obtained respectively for (+)-and (-)-PQ. The extrapolation of in vitro intrinsic clearance to in vivo human hepatic blood clearance, performed using the well-stirred liver model, showed that the rate of hepatic clearance of (+)-PQ was only 45 % that of (-)-PQ. Two major primary routes of metabolism were observed-oxidative deamination of the terminal amine and hydroxylations on the quinoline moiety of PQ. The major deaminated metabolite, carboxyprimaquine (CPQ) was preferentially generated from the (-)-PQ. Other deaminated metabolites including PQ terminal alcohol (m/z 261), a cyclized side chain derivative from the aldehyde (m/z 241), cyclized carboxylic acid derivative (m/z 257), a quinone-imine product of hydroxylated CPQ (m/z 289), CPQ glucuronide (m/z 451) and the glucuronide of PQ alcohol (m/z 437) were all preferentially generated from the (-)-PQ. The major quinoline oxidation product (m/z 274) was preferentially generated from (+)-PQ. In addition to the products of the two metabolic pathways, two other major metabolites were observed: a prominent glycosylated conjugate of PQ on the terminal amine (m/z 422), peaking by 30 min and preferentially generated by (+)-PQ; and the carbamoyl glucuronide of PQ (m/z 480) exclusively generated from (+)-PQ.
Conclusion: Metabolism of PQ showed enantioselectivity. These findings may provide important information in establishing clinical differences in PQ enantiomers.
C1 [Fasinu, Pius S.; Avula, Bharathi; Tekwani, Babu L.; Nanayakkara, N. P. Dhammika; Wang, Yan-Hong; Herath, H. M. T. Bandara; Elsohly, Mahmoud A.; Khan, Shabana I.; Khan, Ikhlas A.; Walker, Larry A.] Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 USA.
[Tekwani, Babu L.; Khan, Shabana I.; Khan, Ikhlas A.; Walker, Larry A.] Univ Mississippi, Sch Pharm, Dept BioMol Sci, University, MS 38677 USA.
[Elsohly, Mahmoud A.] Univ Mississippi, Sch Pharm, Dept Pharmaceut Sci, University, MS 38677 USA.
[Elsohly, Mahmoud A.] Univ Mississippi, Sch Pharm, Dept Drug Delivery, University, MS 38677 USA.
[Elsohly, Mahmoud A.] ElSohly Labs Inc, 5 Ind Pk Dr, Oxford, MS 38655 USA.
[McChesney, James D.] Ironstone Separat Inc, Oxford, MS 38627 USA.
[Reichard, Gregory A.; Marcsisin, Sean R.] Walter Reed Army Inst Res, Mil Malaria Res Program, Expt Therapeut Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
RP Walker, LA (reprint author), Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 USA.
EM lwalker@olemiss.edu
FU Bill and Melinda Gates Foundation [OPP53288]; US Army Medical Research
and Materiel Command [W81XWH-10-2-0059, W81XWH-13-2-0026]
FX This study was supported by the Bill and Melinda Gates Foundation Phase
I Grand Challenge Explorations Award (OPP53288) and the US Army Medical
Research and Materiel Command Awards Nos. W81XWH-10-2-0059 and
W81XWH-13-2-0026 to the University of Mississippi. The authors thank Dr.
David Jollow, Medical University of South Carolina, for his continuing
input and advice and help in data interpretations.
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PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2875
J9 MALARIA J
JI Malar. J.
PD APR 19
PY 2016
VL 15
AR 224
DI 10.1186/s12936-016-1270-1
PG 12
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA DJ9EZ
UT WOS:000374518100001
PM 27093859
ER
PT J
AU Zeitlin, L
Geisbert, JB
Deer, DJ
Fenton, KA
Bohorov, O
Bohorova, N
Goodman, C
Kim, D
Hiatt, A
Pauly, MH
Velasco, J
Whaley, KJ
Altmann, F
Gruber, C
Steinkellner, H
Honko, AN
Kuehne, AI
Aman, MJ
Sahandi, S
Enterlein, S
Zhan, XG
Enria, D
Geisbert, TW
AF Zeitlin, Larry
Geisbert, Joan B.
Deer, Daniel J.
Fenton, Karla A.
Bohorov, Ognian
Bohorova, Natasha
Goodman, Charles
Kim, Do
Hiatt, Andrew
Pauly, Michael H.
Velasco, Jesus
Whaley, Kevin J.
Altmann, Friedrich
Gruber, Clemens
Steinkellner, Herta
Honko, Anna N.
Kuehne, Ana I.
Aman, M. Javad
Sahandi, Sara
Enterlein, Sven
Zhan, Xiaoguo
Enria, Delia
Geisbert, Thomas W.
TI Monoclonal antibody therapy for Junin virus infection
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE Junin; therapy; immunotherapy; hemorrhagic fever
ID ARGENTINE HEMORRHAGIC-FEVER; GUINEA-PIGS; IMMUNE PLASMA; EFFICACY;
DISEASE; IGG; ENCEPHALITIS; PATHOGENESIS; EXPRESSION; MODEL
AB Countermeasures against potential biothreat agents remain important to US Homeland Security, and many of these pharmaceuticals could have dual use in the improvement of global public health. Junin virus, the causative agent of Argentine hemorrhagic fever (AHF), is an arenavirus identified as a category A high-priority agent. There are no Food and Drug Administration (FDA) approved drugs available for preventing or treating AHF, and the current treatment option is limited to administration of immune plasma. Whereas immune plasma demonstrates the feasibility of passive immunotherapy, it is limited in quantity, variable in quality, and poses safety risks such as transmission of transfusion-borne diseases. In an effort to develop a monoclonal antibody (mAb)-based alternative to plasma, three previously described neutralizing murine mAbs were expressed as mouse-human chimeric antibodies and evaluated in the guinea pig model of AHF. These mAbs provided 100% protection against lethal challenge when administered 2 d after infection (dpi), and one of them(J199) was capable of providing 100% protection when treatment was initiated 6 dpi and 92% protection when initiated 7 dpi. The efficacy of J199 is superior to that previously described for all other evaluated drugs, and its high potency suggests that mAbs like J199 offer an economical alternative to immune plasma and an effective dual use (bioterrorism/public health) therapeutic.
C1 [Zeitlin, Larry; Bohorov, Ognian; Bohorova, Natasha; Goodman, Charles; Kim, Do; Hiatt, Andrew; Pauly, Michael H.; Velasco, Jesus; Whaley, Kevin J.] Mapp Biopharmaceut Inc, San Diego, CA 92121 USA.
[Geisbert, Joan B.; Deer, Daniel J.; Fenton, Karla A.; Geisbert, Thomas W.] Univ Texas Med Branch, Galveston Natl Lab, Galveston, TX 77555 USA.
[Geisbert, Joan B.; Deer, Daniel J.; Fenton, Karla A.; Geisbert, Thomas W.] Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA.
[Altmann, Friedrich; Gruber, Clemens] Univ Nat Resources & Appl Life Sci, Dept Chem, A-1190 Vienna, Austria.
[Steinkellner, Herta] Univ Nat Resources & Appl Life Sci, Dept Appl Genet & Cell Biol, A-1190 Vienna, Austria.
[Honko, Anna N.; Kuehne, Ana I.] US Army Med Res Inst Infect Dis, Virol Div, Frederick, MD 21702 USA.
[Aman, M. Javad; Sahandi, Sara; Enterlein, Sven; Zhan, Xiaoguo] Integrated BioTherapeut Inc, Gaithersburg, MD 20878 USA.
[Enria, Delia] Inst Nacl Enfermedades Virales Humanas, Buenos Aires, DF, Argentina.
[Honko, Anna N.] NIAID, Integrated Res Facil, Frederick, MD 21702 USA.
RP Zeitlin, L (reprint author), Mapp Biopharmaceut Inc, San Diego, CA 92121 USA.; Geisbert, TW (reprint author), Univ Texas Med Branch, Galveston Natl Lab, Galveston, TX 77555 USA.; Geisbert, TW (reprint author), Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA.
EM larry.zeitlin@mappbio.com; twgeisbe@UTMB.EDU
RI Steinkellner, Herta/N-4267-2016;
OI Steinkellner, Herta/0000-0003-4823-1505; Honko, Anna/0000-0001-9165-148X
FU National Institute of Allergy and Infectious Disease [AI111391]
FX We thank Drs. Yuri Gleba and Victor Klimyuk (Icon Genetics) for access
to the magnICON expression technology and Natalie Dobias and the
Research Histopathology Core at UTMB for optimization of the
immunohistochemistry protocol. This publication was made possible by
National Institute of Allergy and Infectious Disease Grant AI111391.
NR 33
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U1 2
U2 6
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD APR 19
PY 2016
VL 113
IS 16
BP 4458
EP 4463
DI 10.1073/pnas.1600996113
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DJ7LV
UT WOS:000374393800062
PM 27044104
ER
PT J
AU Perea, J
Libbey, B
AF Perea, James
Libbey, Brad
TI Development of a heterodyne speckle imager to measure 3 degrees of
vibrational freedom
SO OPTICS EXPRESS
LA English
DT Article
ID VIBROMETRY
AB A laboratory system has demonstrated the measurement of three degrees of vibrational freedom simultaneously through heterodyne speckle imaging. The random interference pattern generated by the illumination of a rough surface with coherent light can be exploited to extract information about the surface motion. The optical speckle pattern is heterodyne mixed with a coherent reference. The recorded optical data is then processed to extract three dimensions of surface motion. Axial velocity is measured by demodulating the received time-varying intensity of high amplitude pixels. Tilt, a gradient of surface displacement, is calculated by measuring speckle translation following extraction of the speckle pattern from the mixed signal. This paper discusses the laboratory sensor concept, signal processing, and experimental results compared with numeric simulations. (C) 2016 Optical Society of America
C1 [Perea, James; Libbey, Brad] US Army, RDECOM CERDEC Night Vis & Elect Sensors Directora, Ft Belvoir, VA 22060 USA.
RP Perea, J (reprint author), US Army, RDECOM CERDEC Night Vis & Elect Sensors Directora, Ft Belvoir, VA 22060 USA.
EM info@nvl.army.mil
NR 24
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U1 1
U2 1
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 1094-4087
J9 OPT EXPRESS
JI Opt. Express
PD APR 18
PY 2016
VL 24
IS 8
BP 8253
EP 8265
DI 10.1364/OE.24.008253
PG 13
WC Optics
SC Optics
GA DJ7KM
UT WOS:000374390300038
PM 27137264
ER
PT J
AU Burgess, E
AF Burgess, Edwin
TI Red Platoon: A True Story of American Valor
SO LIBRARY JOURNAL
LA English
DT Book Review
C1 [Burgess, Edwin] US Army, Combined Arms Res Lib, Ft Leavenworth, KS USA.
RP Burgess, E (reprint author), US Army, Combined Arms Res Lib, Ft Leavenworth, KS USA.
NR 1
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U1 0
U2 0
PU REED BUSINESS INFORMATION
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA
SN 0363-0277
J9 LIBR J
JI Libr. J.
PD APR 15
PY 2016
VL 141
IS 7
BP 101
EP 101
PG 1
WC Information Science & Library Science
SC Information Science & Library Science
GA DJ8BM
UT WOS:000374437100179
ER
PT J
AU Lesho, EP
AF Lesho, Emil P.
TI How Next-Generation Sequencing Might Not Transform Infectious Disease
Practice
SO CLINICAL INFECTIOUS DISEASES
LA English
DT Letter
C1 [Lesho, Emil P.] Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD USA.
RP Lesho, EP (reprint author), WRAIR, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM carolinelesho@yahoo.com
NR 1
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U1 0
U2 0
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1058-4838
EI 1537-6591
J9 CLIN INFECT DIS
JI Clin. Infect. Dis.
PD APR 15
PY 2016
VL 62
IS 8
BP 1052
EP U137
DI 10.1093/cid/ciw008
PG 2
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA DK7EU
UT WOS:000375088500024
PM 26908790
ER
PT J
AU Audet, GN
Dineen, SM
Quinn, CM
Leon, LR
AF Audet, Gerald N.
Dineen, Shauna M.
Quinn, Carrie M.
Leon, Lisa R.
TI Altered hypothalamic inflammatory gene expression correlates with heat
stroke severity in a conscious rodent model
SO BRAIN RESEARCH
LA English
DT Article
DE Heat stroke; Hypothalamus; Hyperthermia; Central nervous system;
Cytokines
ID TUMOR-NECROSIS-FACTOR; SYSTEMIC INFLAMMATION; BRAIN INJURY; HEATSTROKE;
MICE; RECEPTORS; CYTOKINES; STRESS; HYPOTHERMIA; CHEMOKINES
AB It has been suggested that heat-induced hypothalamic damage mediates core temperature (T-c) disturbances during heat stroke (HS) recovery; this is significant as hypothermia and/or fever have been linked to severity and overall pathological insult. However, to date there has been a lack of histological evidence in support of these claims. We hypothesized that local hypothalamic cytokines and/or chemokines, known regulators of T-c are mediating the elevation in T-c during HS recovery even in the absence of histological damage. In experiment 1, the hypothalamus of Fischer 344 rats was examined for 84 cytokine/chemokine genes (real-time PCR) at multiple time points (T-c,T-max, 1, 3, and 10 days) during mild HS recovery. In experiment 2, the hypothalamus of three different HS severities (MILD, moderate [MOD], and severe [SEV]) in rats were examined for the same genes as experiment 1 as well as six oxidative damage markers, at a single intermediate time point (1 day). Systemic cytokines were also analyzed in experiment 2 across the three severities. There were significant alterations in 25 cytokines/chemokines expression at T-c,T-max, but little or no changes in expression at longer time points in experiment 1. In experiment 2 there were significant changes in gene expression in SEV rats only, with MILD and MOD rats showing baseline expression at 1 day, despite an absence of systemic cytokine expression in any severity. There was also no change in any oxidative marker of damage at 1 day, regardless of severity. In conclusion, we show only limited changes during long term recovery from HS, but demonstrate differences in hypothalamic gene expression patterns that may be driving HS pathology and morbidity. These findings contribute to our overall understanding of HS pathology in the CNS, as well as providing avenues for future pharmacological intervention. Published by Elsevier B.V.
C1 [Audet, Gerald N.; Dineen, Shauna M.; Quinn, Carrie M.; Leon, Lisa R.] US Army, Environm Med Res Inst, Thermal & Mt Med Div, Kansas St,Bldg 42, Natick, MA 01760 USA.
RP Audet, GN (reprint author), US Army, Environm Med Res Inst, Thermal & Mt Med Div, Kansas St,Bldg 42, Natick, MA 01760 USA.
EM Gerald.n.audet.ctr@mail.mil
FU U.S. Department of Energy; USAMRMC
FX This research was supported in part by an appointment to the
Postgraduate Research Participation Program at the U.S. Army Medical
Research Institute of Environmental Medicine administered by the Oak
Ridge Institute for Science and Education through an interagency
agreement between the U.S. Department of Energy and USAMRMC
NR 41
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PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0006-8993
EI 1872-6240
J9 BRAIN RES
JI Brain Res.
PD APR 15
PY 2016
VL 1637
BP 81
EP 90
DI 10.1016/j.brainres.2016.01.048
PG 10
WC Neurosciences
SC Neurosciences & Neurology
GA DK0NY
UT WOS:000374610700008
PM 26876741
ER
PT J
AU Onal, H
Woodford, P
Tweddale, SA
Westervelt, JD
Chen, MY
Dissanayake, STM
Pitois, G
AF Oenal, Hayri
Woodford, Philip
Tweddale, Scott A.
Westervelt, James D.
Chen, Mengye
Dissanayake, Sahan T. M.
Pitois, Gauthier
TI A dynamic simulation/optimization model for scheduling restoration of
degraded military training lands
SO JOURNAL OF ENVIRONMENTAL MANAGEMENT
LA English
DT Article
DE Military training; Land damages; Rehabilitation; Simulation;
Optimization
ID FORT RILEY; DISTURBANCE; IMPACTS
AB Intensive use of military vehicles on Department of Defense training installations causes deterioration in ground surface quality. Degraded lands restrict the scheduled training activities and jeopardize personnel and equipment safety. We present a simulation-optimization approach and develop a discrete dynamic optimization model to determine an optimum land restoration for a given training schedule and availability of financial resources to minimize the adverse effects of training on military lands. The model considers weather forecasts, scheduled maneuver exercises, and unique qualities and importance of the maneuver areas. An application of this approach to Fort Riley, Kansas, shows that: i) starting with natural conditions, the total amount of training damages would increase almost linearly and exceed a quarter of the training area and 228 gullies would be formed (mostly in the intensive training areas) if no restoration is carried out over 10 years; ii) assuming an initial state that resembles the present conditions, sustaining the landscape requires an annual restoration budget of $957 thousand; iii) targeting a uniform distribution of maneuver damages would increase the total damages and adversely affect the overall landscape quality, therefore a selective restoration strategy may be preferred; and iv) a proactive restoration strategy would be optimal where land degradations are repaired before they turn into more severe damages that are more expensive to repair and may pose a higher training risk. The last finding can be used as a rule-of-thumb for land restoration efforts in other installations with similar characteristics. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Oenal, Hayri; Chen, Mengye; Dissanayake, Sahan T. M.; Pitois, Gauthier] Univ Illinois, Dept Agr & Consumer Econ, 1301 W Gregory Dr, Urbana, IL 61822 USA.
[Woodford, Philip] Woodford & Woodford Inc, 2822 Tatarrax Dr, Manhattan, KS 66502 USA.
[Tweddale, Scott A.; Westervelt, James D.] US Army, Corps Engineers, ERDC CERL, POB 9005, Champaign, IL 61822 USA.
RP Onal, H (reprint author), Univ Illinois, Dept Agr & Consumer Econ, 1301 W Gregory Dr, Urbana, IL 61822 USA.
EM h-onal@illinois.edu
OI Onal, Hayri/0000-0002-0307-1731; Dissanayake, Sahan/0000-0002-4342-5979
FU US Army Engineer and Development Center; Construction Engineering
Research Laboratory (CERL) [W9132T-10-2-0016]; USDA National Institute
of Food and Agriculture, Hatch Project [ILLU 05-0361]
FX This study is partially supported by the US Army Engineer and
Development Center and Construction Engineering Research Laboratory
(CERL Agreement W9132T-10-2-0016 and the USDA National Institute of Food
and Agriculture, Hatch Project No. ILLU 05-0361.
NR 21
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U1 3
U2 7
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0301-4797
EI 1095-8630
J9 J ENVIRON MANAGE
JI J. Environ. Manage.
PD APR 15
PY 2016
VL 171
BP 144
EP 157
DI 10.1016/j.jenvman.2016.02.005
PG 14
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA DH3IO
UT WOS:000372680900017
PM 26895721
ER
PT J
AU Wilson, DT
Barnes, BC
Wu, DT
Sum, AK
AF Wilson, Daniel T.
Barnes, Brian C.
Wu, David T.
Sum, Amadeu K.
TI Molecular dynamics simulations of the formation of ethane clathrate
hydrates
SO FLUID PHASE EQUILIBRIA
LA English
DT Article
DE Molecular simulation; Hydrates; Ethane; Nucleation; Formation
ID NUCLEATION
AB This study details molecular dynamics simulations for the formation of ethane clathrate hydrates. Ethane hydrate nucleation shares with methane hydrate nucleation the formation of coordinated guest clusters in water, resulting in structures such as guest-saturated pentagonal and hexagonal faces. Ethane hydrate also forms structure I, which consists of two 5(12) and six 5(12)6(2) cages in its unit cell. Observations from the simulations reveal differences between methane and ethane in the nucleation process, including the types and occupancies of cages. While the formation of occupied 5(12) cages dominates methane hydrate nucleation, nucleation of ethane hydrates predominately exhibits the 4(1)5(10)6(2) cage as both the first and most common early cage type. These 4(1)5(10)6(2) cages do not occur in the crystal structure, and due to their oblong shape, restrict the orientation of the coordinated guest ethane molecule. The initial kinetically favored 4(1)5(10)6(2) cages are observed to undergo transformation into different cage types, such as the thermodynamically favored 5(12)6(2) cage. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Wilson, Daniel T.; Barnes, Brian C.; Sum, Amadeu K.] Colorado Sch Mines, Dept Chem & Biol Engn, 1500 Illinois St, Golden, CO 80401 USA.
[Barnes, Brian C.] US Army, Res Lab, RDRL WML B, Energet Mat Sci Branch, Aberdeen Proving Ground, MD 21005 USA.
[Wu, David T.] Colorado Sch Mines, Dept Chem, 1500 Illinois St, Golden, CO 80401 USA.
RP Sum, AK (reprint author), Colorado Sch Mines, Dept Chem & Biol Engn, 1500 Illinois St, Golden, CO 80401 USA.; Wu, DT (reprint author), Colorado Sch Mines, Dept Chem, 1500 Illinois St, Golden, CO 80401 USA.
EM dwu@mines.edu; asum@mines.edu
RI Sum, Amadeu/B-1103-2009
OI Sum, Amadeu/0000-0003-1903-4537
FU U.S. National Science Foundation [CHE-1125235]; CSM Hydrate Consortium;
BP; Champion Technologies; Chevron; ConocoPhillips; ENI; ExxonMobil;
Halliburton; Instituto Mexicano del Petroleo; Multi-Chem; Nalco;
Petrobras; Schlumberger; Shell; SPT Group; Statoil; Total; NSF; National
Renewable Energy Laboratory
FX We acknowledge Dr. Parag Adhanghale for the initial work on this
project. This work was partially funded by the U.S. National Science
Foundation (CHE-1125235) and the CSM Hydrate Consortium (current and
past members: BP, Champion Technologies, Chevron, ConocoPhillips, ENI,
ExxonMobil, Halliburton, Instituto Mexicano del Petroleo, Multi-Chem,
Nalco, Petrobras, Schlumberger, Shell, SPT Group, Statoil, and Total).
The simulations were performed on HPC facilities at the Golden Energy
Computing Organization at the Colorado School of Mines using resources
acquired with financial assistance from the NSF and the National
Renewable Energy Laboratory.
NR 16
TC 1
Z9 1
U1 4
U2 23
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-3812
EI 1879-0224
J9 FLUID PHASE EQUILIBR
JI Fluid Phase Equilib.
PD APR 15
PY 2016
VL 413
SI SI
BP 229
EP 234
DI 10.1016/j.fluid.2015.12.001
PG 6
WC Thermodynamics; Chemistry, Physical; Engineering, Chemical
SC Thermodynamics; Chemistry; Engineering
GA DF7RA
UT WOS:000371554100032
ER
PT J
AU Robinson, JA
Varanasi, C
Voevodin, AA
Li, LJ
Robinson, JT
Lou, J
AF Robinson, Joshua A.
Varanasi, Chakrapani
Voevodin, Andrey A.
Li, Lain-Jong
Robinson, Jeremy T.
Lou, Jun
TI TWO-DIMENSIONAL HETEROSTRUCTURE MATERIALS
SO JOURNAL OF MATERIALS RESEARCH
LA English
DT Editorial Material
C1 [Robinson, Joshua A.] Penn State Univ, University Pk, PA 16802 USA.
[Varanasi, Chakrapani] US Army, Res Off, Washington, DC USA.
[Voevodin, Andrey A.] US Air Force, Res Lab, Wright Patterson AFB, OH USA.
[Li, Lain-Jong] King Abdullah Univ Sci & Technol, Thuwal, Saudi Arabia.
[Robinson, Jeremy T.] Naval Res Lab, Washington, DC 20375 USA.
[Lou, Jun] Rice Univ, Houston, TX 77251 USA.
RP Robinson, JA (reprint author), Penn State Univ, University Pk, PA 16802 USA.
RI Li, Lain-Jong/D-5244-2011
OI Li, Lain-Jong/0000-0002-4059-7783
NR 0
TC 0
Z9 0
U1 5
U2 17
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0884-2914
EI 2044-5326
J9 J MATER RES
JI J. Mater. Res.
PD APR 14
PY 2016
VL 31
IS 7
BP 823
EP 823
DI 10.1557/jmr.2016.108
PG 1
WC Materials Science, Multidisciplinary
SC Materials Science
GA DM2LN
UT WOS:000376178400001
ER
PT J
AU Bleckmann, M
Eichhorst, M
Schuch, M
Kreuzer, W
Hammond, VH
Spiller, C
Meyer, LW
Herzig, N
AF Bleckmann, M.
Eichhorst, M.
Schuch, M.
Kreuzer, W.
Hammond, V. H.
Spiller, C.
Meyer, L. W.
Herzig, N.
TI The influence of selected ECAP-processing routes on the material
properties of Magnesium Elektron 675
SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES
MICROSTRUCTURE AND PROCESSING
LA English
DT Article
DE Magnesium alloys; Equal channel angular pressing; Mechanical
characterization; EBSD
ID CHANNEL ANGULAR EXTRUSION; MECHANICAL-PROPERTIES; MG ALLOY;
CRYSTALLOGRAPHIC TEXTURE; MICROSTRUCTURE; BEHAVIOR; ANISOTROPY;
DUCTILITY; EVOLUTION; STRENGTH
AB Due to the continued interest in reducing weight in both automobile and aerospace structures, interest has grown in magnesium based alloys as a possible materials solution. Despite this interest, these alloys have not been widely utilized due to their relatively poor mechanical properties in comparison to other material systems. However, recent research has clearly indicated that improved mechanical properties can be achieved in these alloys through the use of severe plastic deformation processing methods. In this report, we examine the influence of equal channel angular pressing on the mechanical response of Elektron 675, a Mg-Gd-Y alloy. Results indicate that an appreciable increase in total elongation and absorbed energy can be obtained depending on the selected processing route. However, these improvements in elongation are somewhat offset by a slight reduction in tensile strength. The observed mechanical response is explained through microstructural analysis as well as texture measurements. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Bleckmann, M.; Schuch, M.; Kreuzer, W.; Hammond, V. H.] Wehrwissensch Inst Werk & Betriebsstoffe WIWeB, Inst Weg 1, D-85435 Erding, Germany.
[Eichhorst, M.; Spiller, C.; Meyer, L. W.; Herzig, N.] Nordmetall GmbH, Mat & Impact Engn, Hauptstr fte 16, D-09221 Adorf Erzgebirge, Germany.
[Hammond, V. H.] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD USA.
RP Bleckmann, M (reprint author), Wehrwissensch Inst Werk & Betriebsstoffe WIWeB, Inst Weg 1, D-85435 Erding, Germany.
EM MatthiasBleckmann@bundeswehr.org
FU Office of the Deputy Assistant Secretary for Defense Exports and
Cooperation (DASA (DEC))
FX In addition, one of the authors (VHH) would like to acknowledge funding
received from the Office of the Deputy Assistant Secretary for Defense
Exports and Cooperation (DASA (DE&C)) that enabled his appointment to
WIWeB as part of the U.S. Department of Defense Engineer and Scientist
Exchange Program.
NR 36
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U1 6
U2 14
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0921-5093
EI 1873-4936
J9 MAT SCI ENG A-STRUCT
JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process.
PD APR 13
PY 2016
VL 660
BP 108
EP 117
DI 10.1016/j.msea.2016.02.059
PG 10
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary;
Metallurgy & Metallurgical Engineering
SC Science & Technology - Other Topics; Materials Science; Metallurgy &
Metallurgical Engineering
GA DJ3BH
UT WOS:000374079300015
ER
PT J
AU Mitchell, GA
Wasylkiwskyj, W
AF Mitchell, Gregory A.
Wasylkiwskyj, Wasyl
TI Theoretical anisotropic transverse resonance technique for the design of
low-profile wideband antennas
SO IET MICROWAVES ANTENNAS & PROPAGATION
LA English
DT Article
AB The authors derive an anisotropic transverse resonance technique enabling the design of a low profile, wideband radiating rectangular cavity. They calculate a tapered geometry that preserves an effective half wavelength resonance within a cavity partially loaded with an anisotropic medium. This design results in an antenna profile of lambda(o)/24, with 1.4 octaves of bandwidth, and a realised gain of 3.3-7.2 dB from 210 to 505 MHz. Using an adaption of a coaxial line to waveguide transition, which utilises two flat rectangular probes as a two-port matching network, as well as an external 180 degrees hybrid coupler as a phase splitter, they achieve a voltage standing wave ratio of better than 2:1 across the whole band.
C1 [Mitchell, Gregory A.] US Army Res Lab, RF & Elect Directorate, Adelphi, MD USA.
[Mitchell, Gregory A.; Wasylkiwskyj, Wasyl] George Washington Univ, Dept Elect Engn, Washington, DC USA.
RP Mitchell, GA (reprint author), US Army Res Lab, RF & Elect Directorate, Adelphi, MD USA.; Mitchell, GA (reprint author), George Washington Univ, Dept Elect Engn, Washington, DC USA.
EM gregory.a.mitchell1.civ@mail.mil
NR 11
TC 0
Z9 0
U1 4
U2 4
PU INST ENGINEERING TECHNOLOGY-IET
PI HERTFORD
PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD SG1 2AY, ENGLAND
SN 1751-8725
EI 1751-8733
J9 IET MICROW ANTENNA P
JI IET Microw. Antennas Propag.
PD APR 13
PY 2016
VL 10
IS 5
BP 487
EP 493
DI 10.1049/iet-map.2015.0470
PG 7
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA DJ0IM
UT WOS:000373885700003
ER
PT J
AU Wingard, LA
Johnson, EC
Sabatini, JJ
AF Wingard, Leah A.
Johnson, Eric C.
Sabatini, Jesse J.
TI Efficient method for the cycloaminomethylation of glycoluril
SO TETRAHEDRON LETTERS
LA English
DT Article
DE Synthesis; Cycloaminomethylation; Glycoluril
AB The efficient method for the cycloaminomethylation of glycoluril to yield 2,6-ditert-butylhexahydro-1H,5H-2,3a,4a,6,7a,8a-hexaazacyclopenta[def]fluorene-4,8-dione is described. The material is synthesized employing water as the solvent, and is isolated by filtration. This is an improvement over the previous reported synthetic method, which relied on the use of samarium trichloride catalysis, as well as silica gel column chromatographic purification to obtain the target product. Published by Elsevier Ltd.
C1 [Sabatini, Jesse J.] US Army Res Lab, Energet Technol Branch, Aberdeen Proving Ground, MD 21005 USA.
[Wingard, Leah A.] Oak Ridge Associated Univ, Belcamp, MD 21017 USA.
[Johnson, Eric C.] TKC Global, 13873 Pk Ctr Rd, Herndon, VA 20171 USA.
RP Sabatini, JJ (reprint author), US Army Res Lab, Energet Technol Branch, Aberdeen Proving Ground, MD 21005 USA.
EM jesse.j.sabatini.civ@mail.mil
FU Army Research Laboratory [W911NF-12-2-0019]
FX Research was sponsored by the Army Research Laboratory was accomplished
in part under Cooperative Agreement Number W911NF-12-2-0019. The views
and conclusions contained in this document are those of the authors and
should not be interpreted as representing official policies, either
expressed or implied, of the Army Research Laboratory or the U.S.
Government. The U.S. Government is authorized to reproduce and
distribute reprints for Government purposes notwithstanding any
copyright notation herein.
NR 11
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U1 0
U2 4
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0040-4039
J9 TETRAHEDRON LETT
JI Tetrahedron Lett.
PD APR 13
PY 2016
VL 57
IS 15
BP 1681
EP 1682
DI 10.1016/j.tetlet.2016.03.013
PG 2
WC Chemistry, Organic
SC Chemistry
GA DI5QB
UT WOS:000373552600011
ER
PT J
AU Gonwong, S
Chuenchitra, T
Khantapura, P
Islam, D
Mason, CJ
AF Gonwong, Siriphan
Chuenchitra, Thippawan
Khantapura, Patchariya
Islam, Dilara
Mason, Carl J.
TI Measles susceptibility in young Thai men suggests need for young adult
measles vaccination: a cross sectional study
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Measles; Seroprevalence; Thailand; Young adult; Disease susceptibility;
Vaccination
ID ANTIBODY; SEROPREVALENCE; PREVALENCE
AB Background: Measles remains a major public health concern in Thailand despite the introduction of vaccination since 1984. Similar to other countries, Thailand has experienced numerous measles outbreaks including adult communities such as university student dormitories, prisons, refugee camps, and military recruit camps. These outbreaks raise questions on the seroprotective antibody level in Thai adults.
Methods: To better understand measles susceptibility in young Thai adults, a retrospective measles seroprevalence study on repository serum specimens obtained with informed consent from young Thai men entering the Royal Thai Army (RTA) during 2007-2008 was conducted. A total of 7760 stratified randomized samples were chosen by residence province. Measles IgG titer was measured using a commercial IgG quantitative ELISA kit following the manufacturer's instructions. An antibody level >= 250 International Units per Liter (IU/L) was interpreted as seropositive.
Results: The overall measles seroprevalence was 78.5 % (95 % Confidence Interval: 77.6-79.4 %) with geometric mean titer of 738 IU/L (95 % Confidence Interval: 716-760 IU/L). The measles seroprevalence by province ranged from 59.6 % to 93.1 %. A trend of decreasing seroprevalence in the younger cohorts despite increasing immunization coverage was found. Lower seroprevalence than vaccination coverage was observed in the youngest age group.
Conclusions: To achieve long term measles control and elimination, an integrated two doses vaccination strategy has been implemented in children in Thailand. This nationwide measles seroprevalence study in young adult RTA recruits found a measles seroprevalence lower than WHO's recommendation for measles outbreak prevention and elimination. These results raise concerns for measles control in Thailand. Supplementary immunization in young adults is essential especially in high-risk and densely populated communities to establish herd immunity for outbreak prevention and elimination.
C1 [Gonwong, Siriphan; Khantapura, Patchariya; Islam, Dilara; Mason, Carl J.] Armed Forces Res Inst Med Sci, Dept Enter Dis, 315-6 Rajvithi Rd, Bangkok 10400, Thailand.
[Chuenchitra, Thippawan] Armed Forces Res Inst Med Sci, Div Res, 315-6 Rajvithi Rd, Bangkok 10400, Thailand.
RP Gonwong, S (reprint author), Armed Forces Res Inst Med Sci, Dept Enter Dis, 315-6 Rajvithi Rd, Bangkok 10400, Thailand.
EM siriphang@afrims.org
OI MASON, CARL/0000-0002-3676-2811
FU Armed Forces Health Surveillance Center-Global Emerging Infections
Surveillance and Response System
FX This work was supported by the Armed Forces Health Surveillance
Center-Global Emerging Infections Surveillance and Response System.
NR 24
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U1 0
U2 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD APR 11
PY 2016
VL 16
AR 309
DI 10.1186/s12889-016-2987-z
PG 6
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA DI7WB
UT WOS:000373711600007
PM 27067256
ER
PT J
AU Huber, BR
Meabon, JS
Hoffer, ZS
Zhang, J
Hoekstra, JG
Pagulayan, KF
McMillan, PJ
Mayer, CL
Banks, WA
Kraemer, BC
Raskind, MA
McGavern, DB
Peskind, ER
Cook, DG
AF Huber, B. R.
Meabon, J. S.
Hoffer, Z. S.
Zhang, J.
Hoekstra, J. G.
Pagulayan, K. F.
McMillan, P. J.
Mayer, C. L.
Banks, W. A.
Kraemer, B. C.
Raskind, M. A.
McGavern, D. B.
Peskind, E. R.
Cook, D. G.
TI BLAST EXPOSURE CAUSES DYNAMIC MICROGLIAL/MACROPHAGE RESPONSES AND
MICRODOMAINS OF BRAIN MICROVESSEL DYSFUNCTION
SO NEUROSCIENCE
LA English
DT Article
DE blood-brain barrier; two-photon microscopy; neuropathology; microglia;
macrophages
ID CHRONIC TRAUMATIC ENCEPHALOPATHY; IN-VIVO; MICROGLIAL ACTIVATION;
WHITE-MATTER; MOUSE MODEL; INJURY; BLOOD; BARRIER; CORTEX; IMPACT
AB Exposure to blast overpressure (BOP) is associated with behavioral, cognitive, and neuroimaging abnormalities. We investigated the dynamic responses of cortical vasculature and its relation to microglia/macrophage activation in mice using intravital two-photon microscopy following mild blast exposure. We found that blast caused vascular dysfunction evidenced by microdomains of aberrant vascular permeability. Microglial/macrophage activation was specifically associated with these restricted microdomains, as evidenced by rapid microglial process retraction, increased ameboid morphology, and escape of blood-borne Q-dot tracers that were internalized in microglial/macrophage cell bodies and phagosome-like compartments. Microdomains of cortical vascular disruption and microglial/macrophage activation were also associated with aberrant tight junction morphology that was more prominent after repetitive (3 x) blast exposure. Repetitive, but not single, BOPs also caused TNF alpha elevation two weeks post-blast. In addition, following a single BOP we found that aberrantly phosphorylated tau rapidly accumulated in perivascular domains, but cleared within four hours, suggesting it was removed from the perivascular area, degraded, and/or dephosphorylated. Taken together these findings argue that mild blast exposure causes an evolving CNS insult that is initiated by discrete disturbances of vascular function, thereby setting the stage for more protracted and more widespread neuro-inflammatory responses. Published by Elsevier Ltd. on behalf of IBRO.
C1 [Huber, B. R.] Boston Univ, VA Jamaica Plain, Dept Neurol, Sch Med, Jamaica Plain, MA USA.
[Meabon, J. S.; Pagulayan, K. F.; McMillan, P. J.; Mayer, C. L.; Raskind, M. A.; Peskind, E. R.] VA Puget Sound Healthcare Syst, Northwest Network Mental Illness Res Educ & Clin, Seattle, WA USA.
[Meabon, J. S.; Pagulayan, K. F.; McMillan, P. J.; Mayer, C. L.; Raskind, M. A.; Peskind, E. R.] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98108 USA.
[Hoffer, Z. S.] US Army, Madigan Army Med Ctr, Joint Base Lewis Mcchord, WA USA.
[Zhang, J.; Hoekstra, J. G.] Univ Washington, Sch Med, Dept Pathol, Seattle, WA 98108 USA.
[Banks, W. A.; Kraemer, B. C.; Cook, D. G.] Vet Affairs Puget Sound Hlth Care Syst, GRECC, Seattle, WA USA.
[Banks, W. A.; Kraemer, B. C.; Cook, D. G.] Univ Washington, Dept Med, Div Gerontol & Geriatr Med, Seattle, WA 98108 USA.
[McGavern, D. B.] NINDS, NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA.
[Cook, D. G.] Univ Washington, Sch Med, Dept Pharmacol, Seattle, WA 98108 USA.
RP Cook, DG (reprint author), Univ Washington, VA Puget Sound Hlth Care Syst, Dept Med, 1660 South Columbian Way, Seattle, WA 98108 USA.
EM dgcook@u.washington.edu
OI Hoekstra, Jake/0000-0001-6597-5878
FU Department of Veterans Affairs Office of Research and Development
Medical Research Service; VA Rehabilitation Research and Development
Service; University of Washington Royalty Research Fund [R01AG046619];
Northwest Network Mental Illness Research, Education and Clinical
Center; Office of Academic Affiliations, Advanced Fellowship Program in
Mental Illness Research and Treatment, Department of Veterans Affairs;
NIH [T32 AG000258]; VA CSR&D Career Development Award [IK2 CX00516]
FX This work was supported by the Department of Veterans Affairs Office of
Research and Development Medical Research Service (D.G.C., B.C.K.), VA
Rehabilitation Research and Development Service (E.R.P.), University of
Washington Royalty Research Fund (D.G.C.); R01AG046619 (W.A.B.);
Northwest Network Mental Illness Research, Education and Clinical Center
(E.R.P., B.R.H., J.S.M., K.F.P., P.J.M., C.L.M.), Office of Academic
Affiliations, Advanced Fellowship Program in Mental Illness Research and
Treatment, Department of Veterans Affairs (B.R.H.); NIH T32 AG000258
(J.S.M.), VA CSR&D Career Development Award Program #IK2 CX00516
(K.F.P.). We thank Dr. Gerard Schellenberg (Univ. Pennsylvania) for
providing Tau knock-out samples.
NR 41
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U1 2
U2 15
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4522
EI 1873-7544
J9 NEUROSCIENCE
JI Neuroscience
PD APR 5
PY 2016
VL 319
BP 206
EP 220
DI 10.1016/j.neuroscience.2016.01.022
PG 15
WC Neurosciences
SC Neurosciences & Neurology
GA DD9RD
UT WOS:000370262400019
PM 26777891
ER
PT J
AU Singamaneni, SR
Punugupati, S
Prater, JT
Narayan, J
AF Singamaneni, Srinivasa Rao
Punugupati, Sandhyarani
Prater, John T.
Narayan, Jagdish
TI Diamagnetism to ferromagnetism in Sr-substituted epitaxial BaTiO3 thin
films
SO APPLIED PHYSICS LETTERS
LA English
DT Article
ID LAALO3/SRTIO3 INTERFACE; SUPERCONDUCTIVITY; COEXISTENCE; DEPOSITION;
GROWTH; LAYER
AB We report on the ferromagnetic-like behavior in otherwise diamagnetic BaTiO3 (BTO) thin films upon doping with non-magnetic element Sr having the composition Ba0.4Sr0.6TiO3 (BST). The epitaxial integration of BST (similar to 800 nm) thick films on Si (100) substrate was achieved using MgO (40 nm) and TiN (20 nm) as buffer layers to prepare BST/MgO/TiN/Si (100) heterostructure by pulsed laser deposition. The c-axis oriented and cube-on-cube epitaxial BST is formed on Si (100) as evidenced by the in-plane and out-of-plane X-ray diffraction. All the deposited films are relaxed through domain matching epitaxy paradigm as observed from X-ray diffraction pattern and A(1)TO(3) mode (at 521.27 cm(-1)) of Raman spectra. As-deposited BST thin films reveal ferromagnetic-like properties, which persist up to 400 K. The magnetization decreases two-fold upon oxygen annealing. In contrast, as-deposited un-doped BTO films show diamagnetism. Electron spin resonance measurements reveal no evidence of external magnetic impurities. XRD and X-ray photoelectron spectroscopy spectra show significant changes influenced by Sr doping in BTO. The ferromagnetic-like behavior in BST could be due to the trapped electron donors from oxygen vacancies resulting from Sr-doping. (C) 2016 AIP Publishing LLC.
C1 [Singamaneni, Srinivasa Rao; Prater, John T.] US Army, Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA.
[Singamaneni, Srinivasa Rao; Punugupati, Sandhyarani; Prater, John T.; Narayan, Jagdish] N Carolina State Univ, Dept Mat Sci & Engn, Box 7907, Raleigh, NC 27695 USA.
RP Singamaneni, SR (reprint author), US Army, Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA.; Singamaneni, SR (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Box 7907, Raleigh, NC 27695 USA.
EM ssingam@ncsu.edu
FU National Academy of Science (NAS), USA; Army Research Office
[W911NF-04-D-0003]; State of North Carolina; National Science Foundation
FX S.R.S. acknowledges National Academy of Science (NAS), USA, for awarding
the NRC postdoctoral research associate fellowship. The authors are
pleased to acknowledge the support of the Army Research Office under
Grant No. W911NF-04-D-0003. We thank Dr. L. Cao and Dr. Alex Smirnov for
their help in Raman and ESR measurements, respectively. Also, the
authors acknowledge the use of the Analytical Instrumentation Facility
(AIF) at North Carolina State University, which is supported by the
State of North Carolina and the National Science Foundation.
NR 37
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U1 19
U2 36
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0003-6951
EI 1077-3118
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD APR 4
PY 2016
VL 108
IS 14
AR 142407
DI 10.1063/1.4945683
PG 5
WC Physics, Applied
SC Physics
GA DJ5EX
UT WOS:000374230700032
ER
PT J
AU Shen, TC
Drost, RJ
Sadler, BM
Rzasa, JR
Davis, CC
AF Shen, Thomas C.
Drost, Robert J.
Sadler, Brian M.
Rzasa, John R.
Davis, Christopher C.
TI Omnidirectional beacon-localization using a catadioptric system
SO OPTICS EXPRESS
LA English
DT Article
ID VISIBLE-LIGHT COMMUNICATION; OPTICAL COMMUNICATION; OBSTACLE DETECTION;
TRACKING; NAVIGATION; ERROR; ROBOT; LINK; ACQUISITION; VARIABLES
AB We present a catadioptric beacon localization system that can provide mobile network nodes with omnidirectional situational awareness of neighboring nodes. In this system, a receiver composed of a hyperboloidal mirror and camera is used to estimate the azimuth, elevation, and range of an LED beacon. We provide a general framework for understanding the propagation of error in the angle-of-arrival estimation and then present an experimental realization of such a system. The situational awareness provided by the proposed system can enable the alignment of communication nodes in an optical wireless network, which may be particularly useful in addressing RF-denied environments. (C) 2016 Optical Society of America
C1 [Shen, Thomas C.; Rzasa, John R.; Davis, Christopher C.] Univ Maryland, Elect & Comp Engn Dept, College Pk, MD 20742 USA.
[Drost, Robert J.; Sadler, Brian M.] US Army Res Lab, Adelphi, MD 20783 USA.
RP Shen, TC (reprint author), Univ Maryland, Elect & Comp Engn Dept, College Pk, MD 20742 USA.
EM tshen@umd.edu
FU U.S. Army Research Office (ARO) [W911NF-13-1-0003]
FX Research at the University of Maryland was supported by U.S. Army
Research Office (ARO) under grant number W911NF-13-1-0003.
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U1 0
U2 9
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 1094-4087
J9 OPT EXPRESS
JI Opt. Express
PD APR 4
PY 2016
VL 24
IS 7
BP 6931
EP 6944
DI 10.1364/OE.24.006931
PG 14
WC Optics
SC Optics
GA DI4KP
UT WOS:000373469100011
PM 27136988
ER
PT J
AU Kim, Y
Wellum, G
Mello, K
Strawhecker, KE
Thoms, R
Giaya, A
Wyslouzil, BE
AF Kim, Yoojeong
Wellum, Glyn
Mello, Kerrianne
Strawhecker, Kenneth E.
Thoms, Richard
Giaya, Arjan
Wyslouzil, Barbara E.
TI Effects of relative humidity and particle and surface properties on
particle resuspension rates
SO AEROSOL SCIENCE AND TECHNOLOGY
LA English
DT Article
DE Nicole Riemer
ID WIND-TUNNEL EXPERIMENTS; ATOMIC-FORCE MICROSCOPE; TURBULENT AIR-FLOW;
INDOOR SURFACES; MICROPARTICLE DETACHMENT; CAPILLARY CONDENSATION;
ADHESION FORCES; HIGH-RESOLUTION; DEPOSITION; MODELS
AB Wind tunnel experiments examined the coupled effects of relative humidity (RH) and surface and particle properties on aerodynamically induced resuspension. Hydrophilic glass spheres and hydrophobic polyethylene spheres similar to 20 mu m in diameter, with nanoscale surface features, were resuspended from hydrophilic glass, hydrophobic chemical agent resistant coating (CARC), and gold surfaces. Roughness of the glass and gold surfaces was on the nanoscale, whereas CARC surfaces had microscale roughness. Different particle-surface combinations yielded van der Waals interactions that varied by a factor of 4, but these differences had a relatively minor effect on resuspension. Wind tunnel RH was varied between 7% and 78%. Overall, RH affected the resuspension of hydrophilic particles on hydrophilic surfaces most strongly and that of hydrophobic particles on hydrophobic surfaces the least. For each particle-surface combination there was a threshold RH value below which resuspension rates were essentially constant and in good agreement with a dimensionless model of particle resuspension.
Copyright (c) 2016 American Association for Aerosol Research
C1 [Kim, Yoojeong; Wellum, Glyn; Mello, Kerrianne; Giaya, Arjan] Triton Syst Inc, 200 Turnpike Rd, Chelmsford, MA 01824 USA.
[Strawhecker, Kenneth E.] Army Res Lab, Aberdeen Proving Ground, MD USA.
[Thoms, Richard] CFD Res Corp, Huntsville, AL USA.
[Wyslouzil, Barbara E.] Ohio State Univ, William G Lowrie Dept Chem & Biomol Engn, Columbus, OH 43210 USA.
[Wyslouzil, Barbara E.] Ohio State Univ, Dept Chem & Biochem, Columbus, OH 43210 USA.
RP Kim, Y (reprint author), Triton Syst Inc, 200 Turnpike Rd, Chelmsford, MA 01824 USA.
EM ykim@tritonsys.com
OI Wyslouzil, Barbara/0000-0001-9763-5990
FU Defense Threat Reduction Agency [HDTRA1-10-C-0069]
FX Support for this work was provided by the Defense Threat Reduction
Agency under contract HDTRA1-10-C-0069. The views expressed herein are
those of the authors and not necessarily those of the Department of
Defense, the Defense Threat Reduction Agency, or any other agency or
component of the US Government.
NR 62
TC 1
Z9 1
U1 5
U2 17
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0278-6826
EI 1521-7388
J9 AEROSOL SCI TECH
JI Aerosol Sci. Technol.
PD APR 2
PY 2016
VL 50
IS 4
BP 339
EP 352
DI 10.1080/02786826.2016.1152350
PG 14
WC Engineering, Chemical; Engineering, Mechanical; Environmental Sciences;
Meteorology & Atmospheric Sciences
SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric
Sciences
GA DI1VV
UT WOS:000373285600004
ER
PT J
AU Campbell, DJ
Campbell, KM
AF Campbell, Donald J.
Campbell, Kathleen M.
TI Police/military convergence in the USA as organisational mimicry
SO POLICING & SOCIETY
LA English
DT Article
DE police/military convergence; organisational mimicry
ID GARRISON STATE; UNITED-STATES; POLICE; MILITARY; SOLDIERS; ATTITUDES;
AMERICA; ARMY; AGE
AB This paper examines the developing convergence between the police and the military, two institutions American society has traditionally separated to safeguard civil liberty. The analysis results in three main conclusions. First, when viewed in a broader sociopolitical context, the current convergence is less singular than it appears, with such overlaps occurring periodically in the past. Second, organisational mimicry offers a conceptual framework for understanding the current convergence. Third, the convergence remains a significant political development, requiring further organisational and social assessment. The paper concludes with a brief discussion of a potential alternative to the convergence.
C1 [Campbell, Donald J.; Campbell, Kathleen M.] US Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA.
RP Campbell, DJ (reprint author), US Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA.
EM LD6829@usma.edu
NR 65
TC 0
Z9 0
U1 2
U2 8
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1043-9463
EI 1477-2728
J9 POLIC SOC
JI Polic. Soc.
PD APR 2
PY 2016
VL 26
IS 3
BP 332
EP 353
DI 10.1080/10439463.2014.942852
PG 22
WC Criminology & Penology
SC Criminology & Penology
GA DI0QI
UT WOS:000373201600005
ER
PT J
AU Njamkepo, E
Fawal, N
Tran-Dien, A
Hawkey, J
Strockbine, N
Jenkins, C
Talukder, KA
Bercion, R
Kuleshov, K
Kolinska, R
Russell, JE
Kaftyreva, L
Accou-Demartin, M
Karas, A
Vandenberg, O
Mather, AE
Mason, CJ
Page, AJ
Ramamurthy, T
Bizet, C
Gamian, A
Carle, I
Sow, AG
Bouchier, C
Wester, AL
Lejay-Collin, M
Fonkoua, MC
Le Hello, S
Blaser, MJ
Jernberg, C
Ruckly, C
Merens, A
Page, AL
Aslett, M
Roggentin, P
Fruth, A
Denamur, E
Venkatesan, M
Bercovier, H
Bodhidatta, L
Chiou, CS
Clermont, D
Colonna, B
Egorova, S
Pazhani, GP
Ezernitchi, AV
Guigon, G
Harris, SR
Izumiya, H
Korzeniowska-Kowal, A
Lutynska, A
Gouali, M
Grimont, F
Langendorf, C
Marejkova, M
Peterson, LAM
Perez-Perez, G
Ngandjio, A
Podkolzin, A
Souche, E
Makarova, M
Shipulin, GA
Ye, CY
Zemlickova, H
Herpay, M
Grimont, PAD
Parkhill, J
Sansonetti, P
Holt, KE
Brisse, S
Thomson, NR
Weill, FX
AF Njamkepo, Elisabeth
Fawal, Nizar
Tran-Dien, Alicia
Hawkey, Jane
Strockbine, Nancy
Jenkins, Claire
Talukder, Kaisar A.
Bercion, Raymond
Kuleshov, Konstantin
Kolinska, Renata
Russell, Julie E.
Kaftyreva, Lidia
Accou-Demartin, Marie
Karas, Andreas
Vandenberg, Olivier
Mather, Alison E.
Mason, Carl J.
Page, Andrew J.
Ramamurthy, Thandavarayan
Bizet, Chantal
Gamian, Andrzej
Carle, Isabelle
Sow, Amy Gassama
Bouchier, Christiane
Wester, Astrid Louise
Lejay-Collin, Monique
Fonkoua, Marie-Christine
Le Hello, Simon
Blaser, Martin J.
Jernberg, Cecilia
Ruckly, Corinne
Merens, Audrey
Page, Anne-Laure
Aslett, Martin
Roggentin, Peter
Fruth, Angelika
Denamur, Erick
Venkatesan, Malabi
Bercovier, Herve
Bodhidatta, Ladaporn
Chiou, Chien-Shun
Clermont, Dominique
Colonna, Bianca
Egorova, Svetlana
Pazhani, Gururaja P.
Ezernitchi, Analia V.
Guigon, Ghislaine
Harris, Simon R.
Izumiya, Hidemasa
Korzeniowska-Kowal, Agnieszka
Lutynska, Anna
Gouali, Malika
Grimont, Francine
Langendorf, Celine
Marejkova, Monika
Peterson, Lorea A. M.
Perez-Perez, Guillermo
Ngandjio, Antoinette
Podkolzin, Alexander
Souche, Erika
Makarova, Mariia
Shipulin, German A.
Ye, Changyun
Zemlickova, Helena
Herpay, Mria
Grimont, Patrick A. D.
Parkhill, Julian
Sansonetti, Philippe
Holt, Kathryn E.
Brisse, Sylvain
Thomson, Nicholas R.
Weill, Francois-Xavier
TI Global phylogeography and evolutionary history of Shigella dysenteriae
type 1
SO NATURE MICROBIOLOGY
LA English
DT Article
ID ESCHERICHIA-COLI; MOLECULAR EPIDEMIOLOGY; PHYLOGENETIC ANALYSIS;
PATHOGENICITY ISLAND; INTERACTIVE TREE; RESISTANCE GENES; PLASMIDS;
SALMONELLA; ANNOTATION; SEQUENCES
AB Together with plague, smallpox and typhus, epidemics of dysentery have been a major scourge of human populations for centuries(1). A previous genomic study concluded that Shigella dysenteriae type 1 (Sd1), the epidemic dysentery bacillus, emerged and spread worldwide after the First World War, with no clear pattern of transmission(2). This is not consistent with the massive cyclic dysentery epidemics reported in Europe during the eighteenth and nineteenth centuries(1,3,4) and the first isolation of Sd1 in Japan in 1897(5). Here, we report a whole-genome analysis of 331 Sd1 isolates from around the world, collected between 1915 and 2011, providing us with unprecedented insight into the historical spread of this pathogen. We show here that Sd1 has existed since at least the eighteenth century and that it swept the globe at the end of the nineteenth century, diversifying into distinct lineages associated with the First World War, Second World War and various conflicts or natural disasters across Africa, Asia and Central America. We also provide a unique historical perspective on the evolution of antibiotic resistance over a 100-year period, beginning decades before the antibiotic era, and identify a prevalent multiple antibiotic-resistant lineage in South Asia that was transmitted in several waves to Africa, where it caused severe outbreaks of disease.
C1 [Njamkepo, Elisabeth; Fawal, Nizar; Tran-Dien, Alicia; Accou-Demartin, Marie; Carle, Isabelle; Lejay-Collin, Monique; Le Hello, Simon; Ruckly, Corinne; Gouali, Malika; Grimont, Francine; Grimont, Patrick A. D.; Weill, Francois-Xavier] Inst Pasteur, Unite Bacteries Pathogenes Enter, F-75724 Paris 15, France.
[Hawkey, Jane; Holt, Kathryn E.] Univ Melbourne, Ctr Syst Genom, Parkville, Vic 3010, Australia.
[Hawkey, Jane; Holt, Kathryn E.] Univ Melbourne, Mol Sci & Biotechnol Inst Bio21, Dept Biochem & Mol Biol, Parkville, Vic 3010, Australia.
[Hawkey, Jane] Univ Melbourne, Sch Agr & Vet Sci, Parkville, Vic 3010, Australia.
[Strockbine, Nancy] Ctr Dis Control & Prevent, Escherichia & Shigella Reference Unit, Atlanta, GA 30333 USA.
[Jenkins, Claire] Publ Hlth England, Gastrointestinal Bacteria Reference Unit, Colindale NW9 5HT, England.
[Talukder, Kaisar A.] Icddr B, Enter & Food Microbiol Lab, Dhaka 1212, Bangladesh.
[Bercion, Raymond] Inst Pasteur, BP 923, Bangui, Cent Afr Republ.
[Bercion, Raymond; Sow, Amy Gassama] Inst Pasteur, BP 220, Dakar, Senegal.
[Kuleshov, Konstantin; Podkolzin, Alexander; Shipulin, German A.] Cent Res Inst Epidemiol, Fed Budget Inst Sci, Moscow 111123, Russia.
[Kolinska, Renata; Zemlickova, Helena] Natl Inst Publ Hlth, CNCTC, Prague 10, Czech Republic.
[Russell, Julie E.] Publ Hlth England, Natl Collect Type Cultures, Porton Down SP4 0JG, England.
[Kaftyreva, Lidia; Egorova, Svetlana; Makarova, Mariia] Pasteur Inst St Petersburg, St Petersburg 197101, Russia.
[Karas, Andreas] Univ KwaZulu Natal, Dept Med Microbiol, ZA-4041 Durban, South Africa.
[Vandenberg, Olivier] Brussels Univ Hosp Lab, Dept Microbiol, LHUB ULB, B-1000 Brussels, Belgium.
[Vandenberg, Olivier] Univ Libre Bruxelles, Sch Publ Hlth, Environm Hlth Res Ctr, B-1070 Brussels, Belgium.
[Mather, Alison E.; Page, Andrew J.; Aslett, Martin; Harris, Simon R.; Parkhill, Julian; Thomson, Nicholas R.; Weill, Francois-Xavier] Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England.
[Mather, Alison E.] Univ Cambridge, Dept Vet Med, Cambridge CB3 0ES, England.
[Mason, Carl J.; Bodhidatta, Ladaporn] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
[Ramamurthy, Thandavarayan; Pazhani, Gururaja P.] NICED, Kolkata 700010, West Bengal, India.
[Bizet, Chantal; Clermont, Dominique] Inst Pasteur, CIP, F-75724 Paris 15, France.
[Gamian, Andrzej; Korzeniowska-Kowal, Agnieszka] Inst Immunol & Expt Therapy, Polish Collect Microorganisms, PL-53114 Wroclaw, Poland.
[Bouchier, Christiane] Inst Pasteur, Plate Forme Genom PF1, F-75724 Paris 15, France.
[Wester, Astrid Louise] Norwegian Inst Publ Hlth, Dept Foodborne Infect, N-0403 Oslo, Norway.
[Fonkoua, Marie-Christine; Ngandjio, Antoinette] Ctr Pasteur Cameroun, BP 1274, Yaounde, Cameroon.
[Blaser, Martin J.; Perez-Perez, Guillermo] NYU, Langone Med Ctr, Dept Med, New York, NY 10016 USA.
[Blaser, Martin J.; Perez-Perez, Guillermo] NYU, Langone Med Ctr, Dept Microbiol, New York, NY 10016 USA.
[Jernberg, Cecilia] Publ Hlth Agcy Sweden, S-17182 Solna, Sweden.
[Merens, Audrey] Begin Mil Hosp, Dept Biol, F-94160 St Mande, France.
[Merens, Audrey] Begin Mil Hosp, Infect Control Unit, F-94160 St Mande, France.
[Page, Anne-Laure; Langendorf, Celine] Epicentre, F-75011 Paris, France.
[Roggentin, Peter] Inst Hyg & Umwelt, D-20539 Hamburg, Germany.
[Fruth, Angelika] Robert Koch Inst, Div Enteropathogen Bacteria & Legionella, D-38855 Wernigerode, Germany.
[Denamur, Erick] Univ Paris Diderot, Sorbonne Paris Cite, INSERM, IAME,UMR 1137, F-75018 Paris, France.
[Venkatesan, Malabi] Walter Reed Army Inst Res, Bacterial Dis Branch, Silver Spring, MD 20910 USA.
[Bercovier, Herve] Hebrew Univ Jerusalem, Fac Med, IL-91120 Jerusalem, Israel.
[Chiou, Chien-Shun] Ctr Dis Control, Ctr Res & Diagnost, Taichung 40855, Taiwan.
[Colonna, Bianca] Sapienza Univ Roma, Dipartimento Biol & Biotecnol C Darwin, Inst Pasteur Fdn Cenci Bolognetti, I-00185 Rome, Italy.
[Ezernitchi, Analia V.] Minist Hlth, Cent Labs, IL-91342 Jerusalem, Israel.
[Guigon, Ghislaine; Brisse, Sylvain] Inst Pasteur, Genotyping Pathogens & Publ Hlth Platform, F-75724 Paris 15, France.
[Izumiya, Hidemasa] Natl Inst Infect Dis, Dept Bacteriol 1, Tokyo 1628640, Japan.
[Lutynska, Anna] Natl Inst Hyg, Natl Publ Hlth Inst, Dept Sera & Vaccines Evaluat, PL-00791 Warsaw, Poland.
[Marejkova, Monika] Natl Inst Publ Hlth, Natl Reference Lab E Coli and Shigella, Prague 10, Czech Republic.
[Peterson, Lorea A. M.] Publ Hlth Agcy Canada, Natl Microbiol Lab, Winnipeg, MB R3E 3R2, Canada.
[Souche, Erika] Inst Pasteur, Bioinformat Platform, F-75724 Paris 15, France.
[Ye, Changyun] China CDC, Natl Inst Communicable Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Beijing 102206, Peoples R China.
[Zemlickova, Helena] Charles Univ Prague, Dept Clin Microbiol, Fac Med, Hradec Kralove 50005, Czech Republic.
[Zemlickova, Helena] Charles Univ Prague, Univ Hosp, Hradec Kralove 50005, Czech Republic.
[Herpay, Mria] Natl Ctr Epidemiol, Hungarian Natl Collect Med Bacteria, H-1097 Budapest, Hungary.
[Sansonetti, Philippe] Inst Pasteur, Unite Pathogenie Microbienne Mol, F-75724 Paris 15, France.
[Brisse, Sylvain] Inst Pasteur, Microbial Evolutionary Genom Unit, F-75724 Paris 15, France.
[Brisse, Sylvain] CNRS, UMR 3525, F-75015 Paris, France.
[Thomson, Nicholas R.] London Sch Hyg & Trop Med, London WC1E 7HT, England.
EM fxweill@pasteur.fr
OI Hawkey, Jane/0000-0001-9661-5293; Grimont, Patrick/0000-0002-6264-136X;
Perez Perez, Guillermo /0000-0002-0131-5798; Korzeniowska-Kowal,
Agnieszka/0000-0001-7569-8018
FU Institut Pasteur; Institut Pasteur International Network; Institut de
Veille Sanitaire; French government's Investissement d'Avenir programme,
Laboratoire d'Excellence 'Integrative Biology of Emerging Infectious
Diseases' [ANR-10-LABX-62-IBEID]; Fondation 'Le Roch-Les Mousquetaires';
Canetti family through the Georges, Jacques et Elias Canetti Award;
Wellcome Trust [098051]; NHMRC of Australia [1061409]; Victorian Life
Sciences Computation Initiative (VLSCI) [VR0082]; Indian Council of
Medical Research, New Delhi, India
FX This study was supported by the Institut Pasteur and the Institut
Pasteur International Network, the Institut de Veille Sanitaire, the
French government's Investissement d'Avenir programme, Laboratoire
d'Excellence 'Integrative Biology of Emerging Infectious Diseases'
(grant no. ANR-10-LABX-62-IBEID), the Fondation 'Le Roch-Les
Mousquetaires', the Canetti family through the Georges, Jacques et Elias
Canetti Award 2013, the Wellcome Trust through grant 098051 to the
Sanger Institute, the NHMRC of Australia (grant 1061409 to K.E.H), the
Victorian Life Sciences Computation Initiative (VLSCI) (grant VR0082)
and the Indian Council of Medical Research, New Delhi, India. The
authors thank A. Dautry-Versat, A.P. Pugsley, C. Brechot and J. Savall
fur their support; T. Hieu, C. Soto, E. Bourreterre and B. Faye for
technical assistance; Z. Szabo, D. Tremblay for providing isolates; L.R.
Hiltzik, N. Baldwin and C. Mackenzie for their searches of the archives;
M. Toucas, H. d'Hauteville, E. Aldova, S. Formal, and A.T. Maurelli for
information about isolates; D. Nedelec for discussion, I. Gut, M. Gut,
L. Ma, D. Harris, K. Oliver and the sequencing teams at the Institut
Pasteur and Wellcome Trust Sanger Institute for sequencing the samples.
The views expressed in this publication are those of the authors and do
not reflect the views of the US Department of the Army or Department of
Defense. The funders had no role in study design, data collection and
analysis, decision to publish, or preparation of the manuscript.
NR 63
TC 3
Z9 3
U1 10
U2 10
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2058-5276
J9 NAT MICROBIOL
JI NAT. MICROBIOL
PD APR
PY 2016
VL 1
IS 4
AR UNSP 16027
DI 10.1038/NMICROBIOL.2016.27
PG 9
WC Microbiology
SC Microbiology
GA DW4HY
UT WOS:000383605000006
PM 27572446
ER
PT J
AU Barbato, RA
Foley, KL
LeWinter, A
Finnegan, D
Vecherin, S
Anderson, JE
Yamamoto, K
Borden, C
Fahy, E
Calandra, N
Reynolds, CM
AF Barbato, Robyn A.
Foley, Karen L.
LeWinter, Adam
Finnegan, David
Vecherin, Sergey
Anderson, John E.
Yamamoto, Kenneth
Borden, Christian
Fahy, Ethan
Calandra, Nathan
Reynolds, Charles M.
TI The Attenuation of Retroreflective Signatures on Surface Soils
SO PHOTOGRAMMETRIC ENGINEERING AND REMOTE SENSING
LA English
DT Article
ID LIDAR; BIODEGRADATION; CALIBRATION
AB Soil parameters such as water potential, temperature, organic matter (OM), and particle size distribution influence biological activity and collectively define the state of soils, yet these properties are typically described through time-intensive, ground-based sampling efforts. To improve our understanding of soils through stand-off sensing techniques, Light Detection and Ranging was used to monitor the signature of retroreflective beads embedded in polymeric agents on four soils. Our goal was to generate probability density functions (PDFs) for stochastic predictions of the persistence of this signature through time. Our findings showed that the PDFs of the reflected signal between target and background soils became nearly indistinguishable after five months and that OM, nitrogen content, cation exchange capacity, and pH related to signature decline. This approach, while developed using polymer-bound retroreflectors, will serve as a framework where a signature-emitter is left in or on soil and differentially influenced by terrain, weather, and soil processes.
C1 [Barbato, Robyn A.; Foley, Karen L.; LeWinter, Adam; Finnegan, David; Vecherin, Sergey; Yamamoto, Kenneth; Reynolds, Charles M.] US Army, ERDC Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA.
[Anderson, John E.] US Army, ERDC Geospatial Res Lab, 1000 W Cary St,VCU Acad Campus, Richmond, VA 23284 USA.
[Borden, Christian; Fahy, Ethan; Calandra, Nathan] Atmospher & Environm Res, 131 Hartwell Ave, Lexington, MA 02421 USA.
RP Barbato, RA (reprint author), US Army, ERDC Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA.
EM Robyn.A.Barbato@erdc.dren.mil
FU US Army Engineer Research and Development Center, Applied Research
Program Office
FX Three anonymous reviewers contributed greatly to the improvement of the
manuscript. This work was funded through the US Army Engineer Research
and Development Center, Applied Research Program Office. Permission for
publishing this information has been granted by the Chief of Engineers.
NR 33
TC 1
Z9 1
U1 2
U2 2
PU AMER SOC PHOTOGRAMMETRY
PI BETHESDA
PA 5410 GROSVENOR LANE SUITE 210, BETHESDA, MD 20814-2160 USA
SN 0099-1112
EI 2374-8079
J9 PHOTOGRAMM ENG REM S
JI Photogramm. Eng. Remote Sens.
PD APR
PY 2016
VL 82
IS 4
BP 283
EP 289
DI 10.14358/PERS.82.4.283
PG 7
WC Geography, Physical; Geosciences, Multidisciplinary; Remote Sensing;
Imaging Science & Photographic Technology
SC Physical Geography; Geology; Remote Sensing; Imaging Science &
Photographic Technology
GA DX0LZ
UT WOS:000384055000009
ER
PT J
AU Manning, T
Field, R
Klingaman, K
Fair, M
Bolognini, J
Crownover, R
Adam, CP
Panchal, V
Rozumov, E
Grau, H
Matter, P
Beachy, M
Holt, C
Sopok, S
AF Manning, Thelma
Field, Richard
Klingaman, Kenneth
Fair, Michael
Bolognini, John
Crownover, Robin
Adam, Carlton P.
Panchal, Viral
Rozumov, Eugene
Grau, Henry
Matter, Paul
Beachy, Michael
Holt, Christopher
Sopok, Samuel
TI Innovative boron nitride-doped propellants
SO DEFENCE TECHNOLOGY
LA English
DT Article
DE Nano-boron nitride; Additive; Lubricant; Gun barrel; Wear and erosion;
Gun propellant
ID BEHAVIOR; STEELS
AB The U.S. military has a need for more powerful propellants with balanced/stoichiometric amounts of fuel and oxidants. However, balanced and more powerful propellants lead to accelerated gun barrel erosion and markedly shortened useful barrel life. Boron nitride (BN) is an interesting potential additive for propellants that could reduce gun wear effects in advanced propellants (US patent pending 2015-026P). Hexagonal boron nitride is a good lubricant that can provide wear resistance and lower flame temperatures for gun barrels. Further, boron can dope steel, which drastically improves its strength and wear resistance, and can block the formation of softer carbides. A scalable synthesis method for producing boron nitride nano-particles that can be readily dispersed into propellants has been developed. Even dispersion of the nano-particles in a double-base propellant has been demonstrated using a solvent-based processing approach. Stability of a composite propellant with the BN additive was verified. In this paper, results from propellant testing of boron nitride nano-composite propellants are presented, including closed bomb and wear and erosion testing. Detailed characterization of the erosion tester substrates before and after firing was obtained by electron microscopy, inductively coupled plasma and x-ray photoelectron spectroscopy. This promising boron nitride additive shows the ability to improve gun wear and erosion resistance without any destabilizing effects to the propellant. Potential applications could include less erosive propellants in propellant ammunition for large, medium and small diameter fire arms. Production and hosting by Elsevier B.V. on behalf of China Ordnance Society.
C1 [Manning, Thelma; Field, Richard; Klingaman, Kenneth; Fair, Michael; Bolognini, John; Crownover, Robin; Adam, Carlton P.; Panchal, Viral; Rozumov, Eugene; Grau, Henry] US Army RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA.
[Matter, Paul; Beachy, Michael; Holt, Christopher] PH Matter LLC, Columbus, OH USA.
[Sopok, Samuel] Benet Lab, Watervliet, NY USA.
RP Manning, T (reprint author), US Army RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA.
EM thelma.g.manning.civ@mail.mil
NR 13
TC 1
Z9 1
U1 4
U2 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 2214-9147
J9 DEF TECHNOL
JI Def. Technol.
PD APR
PY 2016
VL 12
IS 2
BP 69
EP 80
DI 10.1016/j.dt.2015.10.001
PG 12
WC Engineering, Multidisciplinary
SC Engineering
GA DV8NG
UT WOS:000383193100003
ER
PT J
AU Malbec, LM
Eagle, WE
Musculus, MPB
Schihl, P
AF Malbec, Louis-Marie
Eagle, W. Ethan
Musculus, Mark P. B.
Schihl, Peter
TI Influence of Injection Duration and Ambient Temperature on the Ignition
Delay in a 2.34L Optical Diesel Engine
SO SAE INTERNATIONAL JOURNAL OF ENGINES
LA English
DT Article
ID NON-PREMIXED FLAMES; HIGH-PRESSURE; AUTOIGNITION CHARACTERISTICS;
NUMERICAL SIMULATIONS; NOZZLE GEOMETRY; TURBULENT JETS; MOMENTUM FLUX;
LIFT-OFF; COMBUSTION; FUEL
AB Non-conventional operating conditions and fuels in diesel engines can produce longer ignition delays compared to conventional diesel combustion. If those extended delays are longer than the injection duration, the ignition and combustion progress can be significantly influenced by the transient following the end of injection (EOI), and especially by the modification of the mixture field. The objective of this paper is to assess how those long ignition delays, obtained by injecting at low in-cylinder temperatures (e.g., 760-800K), are affected by EOI. Two multi-hole diesel fuel injectors with either six 0.20mm orifices or seven 0.14mm orifices have been used in a 2.34L single-cylinder optical diesel engine. We consider a range of ambient top dead center (TDC) temperatures at the start of injection from 760-1000K as well as a range of injection durations from 0.5ms to 3.1ms. Ignition delays are computed through the analysis of both cylinder pressure and chemiluminescence imaging. A simplified one-dimensional (1-d) model of the diesel jet, able to match the behavior of a transient injection and entrainment processes, is used to estimate the ensemble-averaged mixture fraction fields during the injection event and at the ignition kernel locations.
At TDC temperatures of 850K or higher, the injection duration is longer than ignition delay, and thus EOI has no effect on ignition delay. At TDC temperatures of 800K or lower, for short injection durations (<1.3ms), ignition occurs after EOI and ignition delay decreases with decreasing injection duration is observed. In addition, the 1-d spray model predicts a decrease of the mixture fraction at ignition kernels with decreasing ignition delay. This is in contrast to the expected trend of increasing kinetic time with decreasing mixture fraction for well-mixed reactors. This suggests that mixture fraction alone is not the first-order parameter influencing the timing and position of ignition sites. The history of the ignition kernel(s) and/or of the scalar dissipation may also need to be considered.
C1 [Malbec, Louis-Marie] IFP Energies Nouvelles, Rueil Malmaison, France.
[Eagle, W. Ethan; Musculus, Mark P. B.] Sandia Natl Labs, Livermore, CA 94550 USA.
[Schihl, Peter] US Army, TARDEC, Warren, MI USA.
RP Malbec, LM (reprint author), IFP Energies Nouvelles, Rueil Malmaison, France.
NR 59
TC 0
Z9 0
U1 2
U2 2
PU SAE INT
PI WARRENDALE
PA 400 COMMONWEALTH DR, WARRENDALE, PA 15096 USA
SN 1946-3936
EI 1946-3944
J9 SAE INT J ENGINES
JI SAE Int. J. Engines
PD APR
PY 2016
VL 9
IS 1
BP 47
EP 70
DI 10.4271/2015-01-1830
PG 24
WC Transportation Science & Technology
SC Transportation
GA DU4NH
UT WOS:000382189300005
ER
PT J
AU Johnson, ZA
Ryan, PM
Anderson, CD
AF Johnson, Zackary A.
Ryan, Paul M.
Anderson, Claude D.
TI Arthroscopic Stabilization for Chronic Latent Syndesmotic Instability
SO ARTHROSCOPY TECHNIQUES
LA English
DT Article
ID DISTAL TIBIOFIBULAR SYNDESMOSIS
AB Subtle syndesmotic instability not evident on radiography can result in chronic ankle pain. The diagnosis is uncommon, and arthroscopic evaluation remains the gold standard for diagnosis. Definitive surgical management can be performed at the time of diagnosis. Patients with 2 to 4 mm of diastasis of the syndesmosis or translation can be treated with debridement alone, and patients with 4 mm or more of diastasis or translation can be treated with arthroscopic debridement and reduction followed by percutaneous stabilization. Percutaneous stabilization is accomplished by a TightRope technique, which involves passing 1 or 2 suture buttons through all 4 cortices of the distal tibia and fibula. This technique is used in lieu of the traditional syndesmotic screw, which requires a subsequent operation for removal.
C1 [Johnson, Zackary A.; Ryan, Paul M.; Anderson, Claude D.] Tripler Army Med Ctr, Honolulu, HI 96859 USA.
RP Johnson, ZA (reprint author), 44-150 Kou Pl,5, Kaneohe, HI 96744 USA.
EM ZackJ83@gmail.com
OI Anderson, Christopher/0000-0002-0053-2002
NR 8
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 2212-6287
J9 ARTHROSC TEC
JI Arthrosc. Tec.
PD APR
PY 2016
VL 5
IS 2
BP E263
EP E268
DI 10.1016/j.eats.2015.12.006
PG 6
WC Orthopedics
SC Orthopedics
GA DU5EO
UT WOS:000382235200009
PM 27354945
ER
PT J
AU Blackley, DJ
Wiley, MR
Ladner, JT
Fallah, M
Lo, T
Gilbert, ML
Gregory, C
D'ambrozio, J
Coulter, S
Mate, S
Balogun, Z
Kugelman, J
Nwachukwu, W
Prieto, K
Yeiah, A
Amegashie, F
Kearney, B
Wisniewski, M
Saindon, J
Schroth, G
Fakoli, L
Diclaro, JW
Kuhn, JH
Hensley, LE
Jahrling, PB
Stroher, U
Nichol, ST
Massaquoi, M
Kateh, F
Clement, P
Gasasira, A
Bolay, F
Monroe, SS
Rambaut, A
Sanchez-Lockhart, M
Laney, AS
Nyenswah, T
Christie, A
Palacios, G
AF Blackley, David J.
Wiley, Michael R.
Ladner, Jason T.
Fallah, Mosoka
Lo, Terrence
Gilbert, Merle L.
Gregory, Christopher
D'ambrozio, Jonathan
Coulter, Stewart
Mate, Suzanne
Balogun, Zephaniah
Kugelman, Jeffrey
Nwachukwu, William
Prieto, Karla
Yeiah, Adolphus
Amegashie, Fred
Kearney, Brian
Wisniewski, Meagan
Saindon, John
Schroth, Gary
Fakoli, Lawrence
Diclaro, Joseph W., II
Kuhn, Jens H.
Hensley, Lisa E.
Jahrling, Peter B.
Stroher, Ute
Nichol, Stuart T.
Massaquoi, Moses
Kateh, Francis
Clement, Peter
Gasasira, Alex
Bolay, Fatorma
Monroe, Stephan S.
Rambaut, Andrew
Sanchez-Lockhart, Mariano
Laney, A. Scott
Nyenswah, Tolbert
Christie, Athalia
Palacios, Gustavo
TI Reduced evolutionary rate in reemerged Ebola virus transmission chains
SO SCIENCE ADVANCES
LA English
DT Article
ID LIBERIA; SURVEILLANCE; OUTBREAK; SPREAD
AB On 29 June 2015, Liberia's respite from Ebola virus disease (EVD) was interrupted for the second time by a renewed outbreak ("flare-up") of seven confirmed cases. We demonstrate that, similar to the March 2015 flare-up associated with sexual transmission, this new flare-up was a reemergence of a Liberian transmission chain originating from a persistently infected source rather than a reintroduction from a reservoir or a neighboring country with active transmission. Although distinct, Ebola virus (EBOV) genomes from both flare-ups exhibit significantly low genetic divergence, indicating a reduced rate of EBOV evolution during persistent infection. Using this rate of change as a signature, we identified two additional EVD clusters that possibly arose from persistently infected sources. These findings highlight the risk of EVD flare-ups even after an outbreak is declared over.
C1 [Blackley, David J.; Lo, Terrence; Gregory, Christopher; Coulter, Stewart; Balogun, Zephaniah; Nwachukwu, William; Saindon, John; Stroher, Ute; Monroe, Stephan S.; Laney, A. Scott; Christie, Athalia] Ctr Dis Control & Prevent, Atlanta, GA 30329 USA.
[Wiley, Michael R.; Ladner, Jason T.; Gilbert, Merle L.; D'ambrozio, Jonathan; Mate, Suzanne; Kugelman, Jeffrey; Prieto, Karla; Kearney, Brian; Wisniewski, Meagan; Sanchez-Lockhart, Mariano; Palacios, Gustavo] US Army, Med Res Inst Infect Dis, Frederick, MD 21702 USA.
[Fallah, Mosoka; Yeiah, Adolphus; Amegashie, Fred; Massaquoi, Moses; Kateh, Francis; Nyenswah, Tolbert] Minist Hlth, Monrovia, Liberia.
[Schroth, Gary] Illumina Inc, San Diego, CA 92122 USA.
[Fakoli, Lawrence; Bolay, Fatorma] Liberian Inst Biomed Res, Charlesville, Liberia.
[Diclaro, Joseph W., II] US Navy, Naval Med Res Unit 3, Cairo, Egypt.
[Kuhn, Jens H.; Hensley, Lisa E.; Jahrling, Peter B.; Nichol, Stuart T.] NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD 21702 USA.
[Clement, Peter; Gasasira, Alex] WHO, CH-1211 Geneva 27, Switzerland.
[Rambaut, Andrew] Univ Edinburgh, Inst Evolutionary Biol, Edinburgh EH9 3FL, Midlothian, Scotland.
[Rambaut, Andrew] NIH, Fogarty Int Ctr, Bldg 10, Bethesda, MD 20892 USA.
[Rambaut, Andrew] Univ Edinburgh, Ctr Immunol Infect & Evolut, Edinburgh EH9 3FL, Midlothian, Scotland.
RP Christie, A (reprint author), Ctr Dis Control & Prevent, Atlanta, GA 30329 USA.; Palacios, G (reprint author), US Army, Med Res Inst Infect Dis, Frederick, MD 21702 USA.; Nyenswah, T (reprint author), Minist Hlth, Monrovia, Liberia.
EM tgnyenswah74@yahoo.com; akc9@cdc.gov; gustavo.f.palacios.ctr@mail.mil
RI Palacios, Gustavo/I-7773-2015
OI Palacios, Gustavo/0000-0001-5062-1938
FU NIAID NIH HHS [HHSN272200700016I]; PHS HHS [HHSN272200700016I]
NR 25
TC 7
Z9 7
U1 1
U2 3
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 2375-2548
J9 SCI ADV
JI Sci. Adv.
PD APR
PY 2016
VL 2
IS 4
AR e1600378
DI 10.1126/sciadv.1600378
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DR7IB
UT WOS:000380072100053
PM 27386513
ER
PT J
AU Giuntini, D
Raethel, J
Herrmann, M
Michaelis, A
Haines, CD
Olevsky, EA
AF Giuntini, Diletta
Raethel, Jan
Herrmann, Mathias
Michaelis, Alexander
Haines, Christopher D.
Olevsky, Eugene A.
TI Spark plasma sintering novel tooling design: temperature uniformization
during consolidation of silicon nitride powder
SO JOURNAL OF THE CERAMIC SOCIETY OF JAPAN
LA English
DT Article
DE Spark plasma sintering; Field-assisted sintering techniques; Tooling;
Finite-element modeling; Silicon nitride
ID STRESS DISTRIBUTIONS; FUNDAMENTAL-ASPECTS; ELECTRIC-FIELD; CERAMICS;
OPTIMIZATION; SCALABILITY; COMPOSITES; MECHANISMS; SIMULATION; EVOLUTION
AB Spark Plasma Sintering (SPS) of silicon nitride is affected by temperature non-uniformities within the powder compact, resulting in density and microstructure inhomogeneities. A double-pyrometer experimental setup reveals a temperature disparity of 100-200 degrees C between the overheated outer surface of the die and the bottom of the upper punch, as a consequence of the electric current concentration through the die's wall characterizing the SPS of non-conductive powders utilizing conventional SPS tooling. A novel tooling design, consisting in the tailored drilling of axial cylindrical or ring-shaped holes within the punch, is individuated and optimized through a campaign of fully-coupled thermal, electrical and mechanical finite element simulations. The analysis of the numerical results, experimentally assessed, allows for a comprehensive understanding of the phenomena underlying radial temperature distributions in SPS and leads to the development of a technological solution for the uniformization of temperature distribution. (C) 2016 The Ceramic Society of Japan. All rights reserved.
C1 [Giuntini, Diletta; Olevsky, Eugene A.] San Diego State Univ, 5500 Campanile Dr, San Diego, CA 92182 USA.
[Raethel, Jan; Herrmann, Mathias; Michaelis, Alexander] Fraunhofer Inst Ceram Technol & Syst IKTS, Winterbergstr 28, D-01277 Dresden, Germany.
[Haines, Christopher D.] US Army ARDEC, Picatinny Arsenal, NJ 07806 USA.
RP Giuntini, D (reprint author), San Diego State Univ, 5500 Campanile Dr, San Diego, CA 92182 USA.
EM dgiuntini@mail.sdsu.edu
RI Michaelis, Alexander/R-9240-2016;
OI Michaelis, Alexander/0000-0002-5987-1252; Herrmann,
Mathias/0000-0003-3264-8672
FU US ARDEC, Picatinny Arsenal [W15QKN-14-C-0068]; US Department of Energy,
Materials Sciences Division [DE-SC0008581]
FX The support of US ARDEC, Picatinny Arsenal (Contract Award
#W15QKN-14-C-0068) is gratefully appreciated. The support of the US
Department of Energy, Materials Sciences Division, under Award No.
DE-SC0008581 is gratefully acknowledged.
NR 57
TC 1
Z9 1
U1 1
U2 2
PU CERAMIC SOC JAPAN-NIPPON SERAMIKKUSU KYOKAI
PI TOKYO
PA 22-17, HYAKUNIN-CHO 2-CHOME, SHINJUKU-KU, TOKYO, 169-0073, JAPAN
SN 1882-0743
EI 1348-6535
J9 J CERAM SOC JPN
JI J. Ceram. Soc. Jpn.
PD APR
PY 2016
VL 124
IS 4
BP 403
EP 414
DI 10.2109/jcersj2.15213
PG 12
WC Materials Science, Ceramics
SC Materials Science
GA DR0PT
UT WOS:000379610100021
ER
PT J
AU Andrews, NA
Latremoliere, A
Basbaum, AI
Mogil, JS
Porreca, F
Rice, ASC
Woolf, CJ
Currie, GL
Dworkin, RH
Eisenach, JC
Evans, S
Gewandter, JS
Gover, TD
Handwerker, H
Huang, W
Iyengar, S
Jensen, MP
Kennedy, JD
Lee, N
Levine, J
Lidster, K
Machin, I
McDermott, MP
McMahon, SB
Price, TJ
Ross, SE
Scherrer, G
Seal, RP
Sena, ES
Silva, E
Stone, L
Svensson, CI
Turk, DC
Whiteside, G
AF Andrews, Nick A.
Latremoliere, Alban
Basbaum, Allan I.
Mogil, Jeffrey S.
Porreca, Frank
Rice, Andrew S. C.
Woolf, Clifford J.
Currie, Gillian L.
Dworkin, Robert H.
Eisenach, James C.
Evans, Scott
Gewandter, Jennifer S.
Gover, Tony D.
Handwerker, Hermann
Huang, Wenlong
Iyengar, Smriti
Jensen, Mark P.
Kennedy, Jeffrey D.
Lee, Nancy
Levine, Jon
Lidster, Katie
Machin, Ian
McDermott, Michael P.
McMahon, Stephen B.
Price, Theodore J.
Ross, Sarah E.
Scherrer, Gregory
Seal, Rebecca P.
Sena, Emily S.
Silva, Elizabeth
Stone, Laura
Svensson, Camilla I.
Turk, Dennis C.
Whiteside, Garth
TI Ensuring transparency and minimization of methodologic bias in
preclinical pain research: PPRECISE considerations
SO PAIN
LA English
DT Article
DE Transparent reporting; Consensus; Bias; Internal validity
ID CLINICAL-TRIALS; ANIMAL-MODELS; MULTIPLICITY; STANDARDS; DRUGS; CALL
AB There is growing concern about lack of scientific rigor and transparent reporting across many preclinical fields of biological research. Poor experimental design and lack of transparent reporting can result in conscious or unconscious experimental bias, producing results that are not replicable. The Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) public-private partnership with the U.S. Food and Drug Administration sponsored a consensus meeting of the Preclinical Pain Research Consortium for Investigating Safety and Efficacy (PPRECISE) Working Group. International participants from universities, funding agencies, government agencies, industry, and a patient advocacy organization attended. Reduction of publication bias, increasing the ability of others to faithfully repeat experimental methods, and increased transparency of data reporting were specifically discussed. Parameters deemed essential to increase confidence in the published literature were clear, specific reporting of an a priori hypothesis and definition of primary outcome measure. Power calculations and whether measurement of minimal meaningful effect size to determine these should be a core component of the preclinical research effort provoked considerable discussion, with many but not all agreeing. Greater transparency of reporting should be driven by scientists, journal editors, reviewers, and grant funders. The conduct of high-quality science that is fully reported should not preclude novelty and innovation in preclinical pain research, and indeed, any efforts that curtail such innovation would be misguided. We believe that to achieve the goal of finding effective new treatments for patients with pain, the pain field needs to deal with these challenging issues.
C1 [Andrews, Nick A.; Latremoliere, Alban; Woolf, Clifford J.] Harvard Univ, Sch Med, Boston Childrens Hosp, Dept Neurobiol, 3 Blackfan Circle, Boston, MA 02115 USA.
[Basbaum, Allan I.] Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA.
[Mogil, Jeffrey S.] McGill Univ, Dept Psychol, Montreal, PQ, Canada.
[Mogil, Jeffrey S.] McGill Univ, Alan Edwards Ctr Res Pain, Montreal, PQ, Canada.
[Porreca, Frank] Univ Arizona, Coll Med, Dept Pharmacol, Tucson, AZ 85724 USA.
[Rice, Andrew S. C.] Univ London Imperial Coll Sci Technol & Med, Dept Surg & Canc, Pain Res, London, England.
[Currie, Gillian L.; Sena, Emily S.] Univ Edinburgh, Ctr Clin Brain Sci, Edinburgh, Midlothian, Scotland.
[Dworkin, Robert H.; Gewandter, Jennifer S.] Univ Rochester, Dept Anesthesiol, Rochester, NY USA.
[Dworkin, Robert H.; McDermott, Michael P.] Univ Rochester, Dept Neurol, Rochester, NY USA.
[Dworkin, Robert H.] Univ Rochester, Dept Psychiat, Rochester, NY USA.
[Eisenach, James C.] Wake Forest Sch Med, Dept Anesthesiol, Winston Salem, NC USA.
[Evans, Scott] Harvard Univ, Dept Biostat, 3 Blackfan Circle, Boston, MA 02115 USA.
[Gover, Tony D.] US Army Med Res & Mat Command, Clin & Rehabilitat Med Res Program, Ft Detrick, MD USA.
[Handwerker, Hermann] Univ Erlangen Nurnberg, Dept Physiol & Pathophysiol, Erlangen, Germany.
[Huang, Wenlong] Univ Aberdeen, Inst Med Sci, Aberdeen, Scotland.
[Iyengar, Smriti] Eli Lilly & Co, Indianapolis, IN 46285 USA.
[Jensen, Mark P.] Univ Washington, Dept Rehabil Med, Seattle, WA 98195 USA.
[Kennedy, Jeffrey D.] Eli Lilly & Co, Neurosci Discovery Res, Indianapolis, IN 46285 USA.
[Lee, Nancy] Wellcome Trust Res Labs, Policy Dept, London, England.
[Levine, Jon] Univ Calif San Francisco, Dept Med, San Francisco, CA USA.
[Levine, Jon] Univ Calif San Francisco, Dept Oral Surg, San Francisco, CA USA.
[Lidster, Katie] Natl Ctr Replacement Refinement & Reduct Anim Res, London, England.
[McDermott, Michael P.] Univ Rochester, Dept Biostat & Computat Biol, Rochester, NY USA.
[McMahon, Stephen B.] Kings Coll London, Neurorestorat Grp, London, England.
[Price, Theodore J.] Univ Texas Dallas, Sch Behav & Brain Sci, Dallas, TX 75230 USA.
[Ross, Sarah E.] Univ Pittsburgh, Dept Neurobiol, Pittsburgh, PA USA.
[Scherrer, Gregory] Stanford Univ, Sch Med, Dept Anesthesiol Perioperat & Pain Med, Palo Alto, CA 94304 USA.
[Seal, Rebecca P.] Univ Calif San Francisco, Off Career & Profess Dev, San Francisco, CA 94143 USA.
[Silva, Elizabeth] McGill Univ, Fac Dent, Montreal, PQ, Canada.
[Stone, Laura] McGill Univ, Alan Edwards Ctr Res Pain, Montreal, PQ, Canada.
[Svensson, Camilla I.] Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.
[Turk, Dennis C.] Univ Washington, Dept Anesthesiol & Pain Med, Seattle, WA 98195 USA.
[Whiteside, Garth] Purdue Pharma, Discovery Res, Cranbury, NJ USA.
RP Andrews, NA (reprint author), Harvard Univ, Sch Med, Boston Childrens Hosp, Kirby Neurobiol Ctr, 3 Blackfan Circle, Boston, MA 02115 USA.
EM Nick.andrews@childrens.harvard.edu
RI Huang, Wenlong/P-2025-2016;
OI Silva, Elizabeth/0000-0002-0684-9473; Sena, Emily S/0000-0002-3282-8502;
Scherrer, Gregory/0000-0002-1983-5126
FU Analgesic; Addiction Clinical Trial Translations, Innovations,
Opportunities, and Networks (ACTTION); Anesthetic; Food and Drug
Administration (FDA); ACTTION; FDA
FX The findings, conclusions, and recommendations in this article are
solely those of the authors, none of whom have financial conflicts of
interest specifically related to the issues discussed in this article.
At the time of the consensus meeting on which this article is based, 3
authors were employed by pharmaceutical companies and others had
received consulting fees or honoraria from one or more pharmaceutical or
device companies. Authors of this article who were not employed by
industry or government at the time of the consensus meeting received
travel stipends, hotel accommodations, and meals during the meeting from
the Analgesic, Anesthetic, and Addiction Clinical Trial Translations,
Innovations, Opportunities, and Networks (ACTTION) public-private
partnership. No official endorsement by the Food and Drug Administration
(FDA) or the pharmaceutical and device companies that have provided
unrestricted grants to support the activities of ACTTION should be
inferred. Financial support for this project was provided by ACTTION,
which has received research contracts, grants, or other revenue from the
FDA, multiple pharmaceutical and device companies, and other sources.
NR 19
TC 2
Z9 2
U1 1
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0304-3959
EI 1872-6623
J9 PAIN
JI Pain
PD APR
PY 2016
VL 157
IS 4
BP 901
EP 909
DI 10.1097/j.pain.0000000000000458
PG 9
WC Anesthesiology; Clinical Neurology; Neurosciences
SC Anesthesiology; Neurosciences & Neurology
GA DP1PJ
UT WOS:000378261600017
PM 26683237
ER
PT J
AU Paech, GM
Della Vedova, C
Pajcin, M
Grant, C
Kamimori, G
Banks, S
AF Paech, Gemma M.
Della Vedova, Chris
Pajcin, Maja
Grant, Crystal
Kamimori, Gary
Banks, Siobhan
TI Caffeine has minimal effects on daytime recovery sleep following severe
sleep deprivation
SO SLEEP AND BIOLOGICAL RHYTHMS
LA English
DT Article
DE Total sleep deprivation; Sleep structure; Fatigue countermeasures;
Stimulants; Daytime recovery
ID PERFORMANCE; ALERTNESS; HUMANS; METABOLISM; ADENOSINE; BIOAVAILABILITY;
HOMEOSTASIS; MODAFINIL; COFFEE; BRAIN
AB Caffeine has been shown to minimise the effects of sleep loss on performance and alertness. However, caffeine may also have negative repercussions for recovery sleep, particularly during the daytime. The current study investigated the impact of high caffeine consumption on daytime recovery sleep following 50 h wakefulness. Twenty-four healthy participants were randomly assigned to either a caffeine (n = 12, aged 22.5 +/- 3.3 years) or placebo condition (n = 12, aged 22.5 +/- 2.5 years). All participants were scheduled to one baseline sleep (22:00-08:00 h) and two nights (50 h) of wakefulness followed by a daytime recovery sleep (10:00-19:00 h). Each night at 01:00, 03:00, 05:00 and 07:00 h during the wake period participants were given 200 mg of caffeine or placebo gum. Caffeine reduced the amount of SWS within the first NREM-REM sleep cycles compared to placebo. However, there were no differences between the caffeine and placebo conditions with relation to the overall amount of SWS, REM sleep, stage 2 sleep, and sleep initiation and consolidation during the recovery sleep. Results suggest that caffeine can be used as a fatigue countermeasure in industries where work hours extend to 50 h without significantly disrupting recovery sleep, even during the daytime. Results may also have implications for workers working extended shifts who use caffeine to help reduce fatigue during the commute home.
C1 [Paech, Gemma M.; Banks, Siobhan] Univ S Australia, Ctr Sleep Res, Adelaide, SA 5001, Australia.
[Paech, Gemma M.; Grant, Crystal] Washington State Univ, Sleep & Performance Res Ctr, POB 1495, Spokane, WA 99210 USA.
[Della Vedova, Chris; Pajcin, Maja] Univ S Australia, Sch Pharm & Med Sci, Adelaide, SA 5001, Australia.
[Kamimori, Gary] Walter Reed Army Inst Res, Behav Biol Branch, Silver Spring, MD USA.
RP Paech, GM (reprint author), Univ S Australia, Ctr Sleep Res, Adelaide, SA 5001, Australia.; Paech, GM (reprint author), Washington State Univ, Sleep & Performance Res Ctr, POB 1495, Spokane, WA 99210 USA.
EM gemma.paech@wsu.edu
RI Della Vedova, Chris/F-4583-2013; Banks, Siobhan/L-2149-2013
OI Della Vedova, Chris/0000-0002-2361-3729; Banks,
Siobhan/0000-0002-7489-0929
FU Defence Science and Technology Organisation, Australian Government,
Department of Defence; US Army Medical Research and Material Command
FX The authors thank participants and staff who helped with data
collection, in particular Katja Morsky, Charitha Sayakkarage, Megan
Dittman and Dong Jae Ryoo for taking biological samples throughout the
study. We would also like to thank Kayla Johnson, Glen Pierce, Philip
Jacques, Justin Fidock and Stephanie Eonta. This work was supported by
the Defence Science and Technology Organisation, Australian Government,
Department of Defence. This work was also supported by the US Army
Medical Research and Material Command. This material has been reviewed
by the Walter Reed Army Institute of Research, and there is no objection
to its presentation and/or publication. The opinions or assertions
contained herein are the private views of the authors and are not to be
construed as official or as reflecting the position of the Department of
the Army of the Department of Defence.
NR 39
TC 0
Z9 0
U1 12
U2 12
PU SPRINGER LONDON LTD
PI LONDON
PA 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND
SN 1446-9235
EI 1479-8425
J9 SLEEP BIOL RHYTHMS
JI Sleep Biol. Rhythms
PD APR
PY 2016
VL 14
IS 2
BP 149
EP 156
DI 10.1007/s41105-015-0031-9
PG 8
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA DP0AO
UT WOS:000378150200005
ER
PT J
AU Goldman, SB
Wolff, A
Root, L
AF Goldman, Sarah B.
Wolff, Aviva
Root, Leon
TI Special Issue: Wrist
SO JOURNAL OF HAND THERAPY
LA English
DT Editorial Material
C1 [Goldman, Sarah B.] US Army, Off Surgeon Gen, Oklahoma City, OK USA.
[Wolff, Aviva; Root, Leon] Hosp Special Surg, Mot Anal Lab, New York, NY USA.
RP Goldman, SB (reprint author), Off Surgeon Gen, 7700 Arlington Blvd, Falls Church, VA 22042 USA.
EM sarah.b.goldman.mil@mail.mil
NR 0
TC 0
Z9 0
U1 0
U2 0
PU HANLEY & BELFUS-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0894-1130
EI 1545-004X
J9 J HAND THER
JI J. Hand Ther.
PD APR-JUN
PY 2016
VL 29
IS 2
BP 95
EP 95
DI 10.1016/j.jht.2016.04.004
PG 1
WC Orthopedics; Rehabilitation; Surgery
SC Orthopedics; Rehabilitation; Surgery
GA DO8GG
UT WOS:000378020600001
PM 27264895
ER
PT J
AU Smith, AN
Jankowski, NR
Boteler, LM
AF Smith, Andrew N.
Jankowski, Nicholas R.
Boteler, Lauren M.
TI Measurement of High-Performance Thermal Interfaces Using a Reduced Scale
Steady-State Tester and Infrared Microscopy
SO JOURNAL OF HEAT TRANSFER-TRANSACTIONS OF THE ASME
LA English
DT Article
DE thermal interface resistance; thermal interface materials; contact
resistance; infrared microscopy; heat transfer
ID CARBON NANOTUBE ARRAYS; NANOCOMPOSITES
AB Thermal interface materials (TIMs) have reached values approaching the measurement uncertainty of standard ASTM D5470 based testers of approximately +/- 1 x 10(-6) m(2) K/W. This paper presents a miniature ASTM/type steady-state tester that was developed to address the resolution limits of standard testers by reducing the heat meter bar thickness and using infrared (IR) thermography to measure the temperature gradient along the heat meter bar. Thermal interfacial resistance measurements on the order of 1 x 10(-6) m(2) K/W with an order of magnitude improvement in the uncertainty of +/- 1 x 10(-7) m(2) K/W are demonstrated. These measurements were made on several TIMs with a thermal resistance as low as 1.14 x 10(-6) m(2) K/W.
C1 [Smith, Andrew N.] US Naval Acad, Annapolis, MD 21402 USA.
[Jankowski, Nicholas R.; Boteler, Lauren M.] US Army Res Lab, Adelphi, MD 20783 USA.
RP Smith, AN (reprint author), US Naval Acad, Annapolis, MD 21402 USA.
EM ansmith@usna.edu; nicholas.r.jankowski.civ@mail.mil;
lauren.m.boteler.civ@mail.mil
NR 23
TC 2
Z9 2
U1 1
U2 1
PU ASME
PI NEW YORK
PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA
SN 0022-1481
EI 1528-8943
J9 J HEAT TRANS-T ASME
JI J. Heat Transf.-Trans. ASME
PD APR
PY 2016
VL 138
IS 4
AR 041301
DI 10.1115/1.4032172
PG 7
WC Thermodynamics; Engineering, Mechanical
SC Thermodynamics; Engineering
GA DO8XB
UT WOS:000378067700001
ER
PT J
AU Ladner, JT
Kuhn, JH
Palacios, G
AF Ladner, J. T.
Kuhn, J. H.
Palacios, G.
TI Standard finishing categories for high-throughput sequencing of viral
genomes
SO REVUE SCIENTIFIQUE ET TECHNIQUE-OFFICE INTERNATIONAL DES EPIZOOTIES
LA English
DT Article
DE Data curation; Genome assembly; High-throughput sequencing; Medical
countermeasure development; Molecular epidemiology; Population genomics;
Virus
ID EBOLA-VIRUS; DIVERSITY; EVOLUTION; DISCOVERY; VARIANTS; SURVEILLANCE;
CORONAVIRUS; POPULATION; EMERGENCE; EPIDEMIC
AB Viral genome sequencing has become the cornerstone of almost all aspects of virology. In particular, high-throughput, next-generation viral genome sequencing has become an integral part of molecular epidemiological investigations into outbreaks of viral disease, such as the recent outbreaks of Middle Eastern respiratory syndrome, Ebola virus disease and Zika virus infection. Multiple institutes have acquired the expertise and necessary infrastructure to perform such investigations, as evidenced by the accumulation of thousands of novel viral sequences over progressively shorter time periods. The authors recently proposed a nomenclature comprised of five high-throughput sequencing standard categories to describe the quality of determined viral genome sequences. These five categories (standard draft, high quality, coding complete, complete and finished) cover all levels of viral genome finishing and can be applied to sequences determined by any technology platform or assembly technique.
C1 [Ladner, J. T.; Palacios, G.] US Army, Med Res Inst Infect Dis, Ctr Genome Sci, Frederick, MD 21702 USA.
[Kuhn, J. H.] NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD USA.
RP Palacios, G (reprint author), US Army, Med Res Inst Infect Dis, Ctr Genome Sci, Frederick, MD 21702 USA.
EM gustavo.f.palacios.ctr@mail.mil
RI Palacios, Gustavo/I-7773-2015
OI Palacios, Gustavo/0000-0001-5062-1938
FU Defense Threat Reduction Agency [1881290]; Battelle Memorial Institute's
prime contract; US National Institute of Allergy and Infectious Diseases
[HHSN272200700016I]
FX This work was partly funded by Defense Threat Reduction Agency Project
No. 1881290 and by Battelle Memorial Institute's prime contract with the
US National Institute of Allergy and Infectious Diseases under Contract
No. HHSN272200700016I. A subcontractor who performed this work is JHK,
an employee of Tunnell Government Services. The authors thank Laura
Bollinger for editing this manuscript.
NR 42
TC 1
Z9 1
U1 42
U2 46
PU OFFICE INT EPIZOOTIES
PI PARIS
PA 12 RUE DE PRONY, 75017 PARIS, FRANCE
SN 0253-1933
J9 REV SCI TECH OIE
JI Rev. Sci. Tech. Off. Int. Epizoot.
PD APR
PY 2016
VL 35
IS 1
BP 43
EP 52
DI 10.20506/rst.35.1.2416
PG 10
WC Veterinary Sciences
SC Veterinary Sciences
GA DO8EA
UT WOS:000378014200004
PM 27217167
ER
PT J
AU McFall, BC
Fritz, HM
AF McFall, Brian C.
Fritz, Hermann M.
TI Physical modelling of tsunamis generated by three-dimensional deformable
granular landslides on planar and conical island slopes
SO PROCEEDINGS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING
SCIENCES
LA English
DT Article
DE landslide; tsunami; physical model; wave generation
ID IMPULSE WAVES; UNDERWATER LANDSLIDES; NUMERICAL SIMULATIONS; SUBAERIAL
LANDSLIDES; CIRCULAR ISLAND; WESTERN NORWAY; SOLITARY WAVES;
WATER-WAVES; SLIDE; SUBMARINE
AB Tsunamis generated by landslides and volcanic island collapses account for some of the most catastrophic events recorded, yet critically important field data related to the landslide motion and tsunami evolution remain lacking. Landslide-generated tsunami source and propagation scenarios are physically modelled in a three-dimensional tsunami wave basin. A unique pneumatic landslide tsunami generator was deployed to simulate landslides with varying geometry and kinematics. The landslides were generated on a planar hill slope and divergent convex conical hill slope to study lateral hill slope effects on the wave characteristics. The leading wave crest amplitude generated on a planar hill slope is larger on average than the leading wave crest generated on a convex conical hill slope, whereas the leading wave trough and second wave crest amplitudes are smaller. Between 1% and 24% of the landslide kinetic energy is transferred into the wave train. Cobble landslides transfer on average 43% more kinetic energy into the wave train than corresponding gravel landslides. Predictive equations for the offshore propagating wave amplitudes, periods, celerities and lengths generated by landslides on planar and divergent convex conical hill slopes are derived, which allow an initial rapid tsunami hazard assessment.
C1 [McFall, Brian C.] US Army Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
[McFall, Brian C.; Fritz, Hermann M.] Georgia Inst Technol, Sch Civil & Environm Engn, Atlanta, GA 30332 USA.
RP McFall, BC (reprint author), US Army Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.; McFall, BC (reprint author), Georgia Inst Technol, Sch Civil & Environm Engn, Atlanta, GA 30332 USA.
EM brian.c.mcfall@usace.army.mil
RI Fritz, Hermann/H-5618-2013
OI Fritz, Hermann/0000-0002-6798-5401
FU National Science Foundation (NSF), Division of Civil, Mechanical and
Manufacturing Innovation awards [CMMI-0421090, CMMI-0936603,
CMMI-0402490, CMMI-0927178]; US Department of Defense through Science,
Mathematics and Research for Transformation fellowship
FX This work was supported by the National Science Foundation (NSF),
Division of Civil, Mechanical and Manufacturing Innovation awards:
CMMI-0421090, CMMI-0936603, CMMI-0402490 and CMMI-0927178, and the US
Department of Defense through the Science, Mathematics and Research for
Transformation fellowship.
NR 88
TC 3
Z9 3
U1 2
U2 7
PU ROYAL SOC
PI LONDON
PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND
SN 1364-5021
EI 1471-2946
J9 P ROY SOC A-MATH PHY
JI Proc. R. Soc. A-Math. Phys. Eng. Sci.
PD APR 1
PY 2016
VL 472
IS 2188
AR 20160052
DI 10.1098/rspa.2016.0052
PG 24
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DO3ZI
UT WOS:000377720900019
PM 27274697
ER
PT J
AU Summers-Stay, D
Voss, C
Cassidy, T
AF Summers-Stay, Douglas
Voss, Clare
Cassidy, Taylor
TI Using a distributional semantic vector space with a knowledge base for
reasoning in uncertain conditions
SO BIOLOGICALLY INSPIRED COGNITIVE ARCHITECTURES
LA English
DT Article
DE Semantic vector space; Knowledge base; Analogy
ID ANALOGY; BRAIN
AB The inherent inflexibility and incompleteness of commonsense knowledge bases (KB) has limited their usefulness. We describe a system called Displacer for performing KB queries extended with the analogical capabilities of the word2vec distributional semantic vector space (DSVS). This allows the system to answer queries with information which was not contained in the original KB in any form. By performing analogous queries on semantically related terms and mapping their answers back into the context of the original query using displacement vectors, we are able to give approximate answers to many questions which, if posed to the KB atone, would return no results.
We also show how the hand-curated knowledge in a KB can be used to increase the accuracy of a DSVS in solving analogy problems. In these ways, a KB and a DSVS can make up for each other's weaknesses. Published by Elsevier B.V.
C1 [Summers-Stay, Douglas; Voss, Clare; Cassidy, Taylor] US Army Res Lab, Adelphi, MD 20783 USA.
RP Summers-Stay, D (reprint author), US Army Res Lab, Adelphi, MD 20783 USA.
EM douglas.a.summers-stay.civ@mail.mil
NR 20
TC 0
Z9 0
U1 2
U2 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 2212-683X
EI 2212-6848
J9 BIOL INSPIR COGN ARC
JI Biol. Inspired Cogn. Archit.
PD APR
PY 2016
VL 16
BP 34
EP 44
DI 10.1016/j.bica.2016.03.002
PG 11
WC Computer Science, Artificial Intelligence; Neurosciences
SC Computer Science; Neurosciences & Neurology
GA DN1OK
UT WOS:000376835100004
ER
PT J
AU Cheruiyot, AC
Auschwitz, JM
Lee, PJ
Yeda, RA
Okello, CO
Leed, SE
Talwar, M
Murthy, T
Gaona, HW
Hickman, MR
Akala, HM
Kamau, E
Johnson, JD
AF Cheruiyot, Agnes C.
Auschwitz, Jennifer M.
Lee, Patricia J.
Yeda, Redemptah A.
Okello, Charles O.
Leed, Susan E.
Talwar, Mayank
Murthy, Tushar
Gaona, Heather W.
Hickman, Mark R.
Akala, Hoseah M.
Kamau, Edwin
Johnson, Jacob D.
TI Assessment of the Worldwide Antimalarial Resistance Network Standardized
Procedure for In Vitro Malaria Drug Sensitivity Testing Using SYBR Green
Assay for Field Samples with Various Initial Parasitemia Levels
SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
LA English
DT Article
ID LINKED-IMMUNOSORBENT-ASSAY; PLASMODIUM-FALCIPARUM; SUSCEPTIBILITY;
CAMBODIA; VALIDATION; EFFICACY; VACCINE
AB The malaria SYBR green assay, which is used to profile in vitro drug susceptibility of Plasmodium falciparum, is a reliable drug screening and surveillance tool. Malaria field surveillance efforts provide isolates with various low levels of parasitemia. To be advantageous, malaria drug sensitivity assays should perform reproducibly among various starting parasitemia levels rather than at one fixed initial value. We examined the SYBR green assay standardized procedure developed by the Worldwide Antimalarial Resistance Network (WWARN) for its sensitivity and ability to accurately determine the drug concentration that inhibits parasite growth by 50% (IC50) in samples with a range of initial parasitemia levels. The initial sensitivity determination of the WWARN procedure yielded a detection limit of 0.019% parasitemia. P. falciparum laboratory strains and field isolates with various levels of initial parasitemia were then subjected to a range of doses of common antimalarials. The IC(50)s were comparable for laboratory strains with between 0.0375% and 0.6% parasitemia and for field isolates with between 0.075% and 0.6% parasitemia for all drugs tested. Furthermore, assay quality (Z') analysis indicated that the WWARN procedure displays high robustness, allowing for drug testing of malaria field samples within the derived range of initial parasitemia. The use of the WWARN procedure should allow for the inclusion of more malaria field samples in malaria drug sensitivity screens that would have otherwise been excluded due to low initial parasitemia levels.
C1 [Cheruiyot, Agnes C.; Yeda, Redemptah A.; Okello, Charles O.; Akala, Hoseah M.; Kamau, Edwin; Johnson, Jacob D.] Kenya Med Res Inst KEMRI Walter Reed Project, US Army Med Res Directorate Kenya USAMRD K, Dept Emerging Infect Dis, Global Emerging Infect Surveillance & Response Sy, Kisumu, Kenya.
[Auschwitz, Jennifer M.; Lee, Patricia J.; Leed, Susan E.; Talwar, Mayank; Murthy, Tushar; Gaona, Heather W.; Hickman, Mark R.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA.
RP Johnson, JD (reprint author), Kenya Med Res Inst KEMRI Walter Reed Project, US Army Med Res Directorate Kenya USAMRD K, Dept Emerging Infect Dis, Global Emerging Infect Surveillance & Response Sy, Kisumu, Kenya.
EM jacob.d.johnson.mil@mail.mil
FU AFHSC-GEIS [C0651_12_KY]
FX AFHSC-GEIS provided funding to Agnes C. Cheruiyot, Redemptah A. Yeda,
Charles O. Okello, Hoseah M. Akala, Edwin Kamau, and Jacob D. Johnson
under grant number C0651_12_KY.
NR 27
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0066-4804
EI 1098-6596
J9 ANTIMICROB AGENTS CH
JI Antimicrob. Agents Chemother.
PD APR
PY 2016
VL 60
IS 4
BP 2417
EP 2424
DI 10.1128/AAC.00527-15
PG 8
WC Microbiology; Pharmacology & Pharmacy
SC Microbiology; Pharmacology & Pharmacy
GA DM6XL
UT WOS:000376496100054
PM 26856829
ER
PT J
AU Tenan, MS
AF Tenan, Matthew S.
TI Quantifying Emergency Department Visits From Sport and Recreation: Focus
on the Lower Extremity and Knee, 1997-2009
SO JOURNAL OF ATHLETIC TRAINING
LA English
DT Article
DE female athletes; general sports trauma; epidemiology; injury
surveillance
ID MEDICAL-CARE SURVEY; GENDER-DIFFERENCES; UNITED-STATES; INJURIES;
EPIDEMIOLOGY; BASKETBALL; FEMALE
AB Context: Few authors have reported nationally representative data on the number of sport and recreation (SR) injuries resulting in emergency department (ED) visitation. The existing studies have only provided 1 or 2 years of data and are not longitudinal in nature.
Objective: To use a novel algorithmic approach to determine if ED visitation is due to SR, resulting in a substantially larger longitudinal dataset.
Design: Descriptive epidemiology study.
Setting: Hospital.
Patients or Other Participants: The National Hospital Ambulatory Medical Care Survey, a stratified random-sample survey of US hospital EDs was combined for years 1997-2009. There were 15 699 unweighted patient visits determined to be from SR.
Main Outcome Measure(s): A custom algorithm classified SR visits based on the International Classification of Diseases, Ninth Revision, Clinical Modification E-code and pattern recognition of narrative text. Sport and recreation visits were assessed by age and categorized according to broad injury classifications. Additional quantification was performed on SR visits for lower extremity and knee-specific injuries. Sample weights were applied to provide national annual estimates.
Results: Annually, 4 243 000 ED visits resulted from SR. The largest classification of injury from SR was sprains and strains (896 000/y). Males had substantially more SR-related ED visits than females (2 929 000/y versus 1 314 000/y). For patients 10-49 years old, 1 093 000 lower extremity and 169 000 knee-specific injury visits annually were from SR. For both injury types, males had a higher rate of ED visitation; however, females had 25% and 39% greater odds of visitation for lower extremity and knee-specific injury, respectively.
Conclusions: The burden on the health system of ED visits from SR was substantial. Males presented in the ED at a higher rate for SR injury, though females had a higher proportion of lower extremity and knee-specific injury ED visitations from SR. This longitudinal analysis of population-level data provides the information to target research on specific subpopulations to mitigate SR injury.
C1 [Tenan, Matthew S.] US Army Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA.
RP Tenan, MS (reprint author), US Army Res Lab, Human Res & Engn Directorate, RDRL HRS B, Aberdeen Proving Ground, MD 21005 USA.
EM matthew.s.tenan.civ@mail.mil
NR 22
TC 0
Z9 0
U1 1
U2 3
PU NATL ATHLETIC TRAINERS ASSOC INC
PI DALLAS
PA 2952 STEMMONS FREEWAY, DALLAS, TX 75247 USA
SN 1062-6050
EI 1938-162X
J9 J ATHL TRAINING
JI J. Athl. Train.
PD APR
PY 2016
VL 51
IS 4
BP 309
EP 316
DI 10.4085/1062-6050-51.4.12
PG 8
WC Sport Sciences
SC Sport Sciences
GA DM6DQ
UT WOS:000376441000005
PM 27075528
ER
PT J
AU Kenefick, RW
Cheuvront, SN
AF Kenefick, Robert W.
Cheuvront, Samuel N.
TI Physiological adjustments to hypohydration: Impact on thermoregulation
SO AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
LA English
DT Review
DE Hypohydration; Dehydration; Fluid deficit; Thermoregulation
ID EXERCISE-HEAT STRESS; BODY-TEMPERATURE; BLOOD-VOLUME; AIR-FLOW;
CUTANEOUS VASODILATION; DEHYDRATION ASSESSMENT; CARDIOVASCULAR DRIFT;
EVAPORATIVE RATES; HYDRATION LEVEL; ELECTRIC FANS
AB Sufficient body water is required to sustain thermoregulatory function, thus losses in total body water (TBW) can challenge the thermoregulatory system. A TBW deficit >= 2% body mass (hypohydration) is recognized as the threshold when thermoregulatory function becomes measurably altered. Hypohydration may occur from voluntary fluid restriction, insufficient fluid availability, or thermoregulatory sweating. The secretion and evaporation of sweat important avenues of body heat loss, and if the water lost is not replaced, hypohydration will decrease plasma volume and increase plasma osmotic pressure (hyperosmotic hypovolemia). Both osmotic and/or volume stressors delay the onset and/or reduce the sensitivity of sweating and blood flow responses. The magnitude of hypohydration, environmental heat stress, the population and circumstances of interest will determine the degree, significance and outcome of these thermoregulatory alterations and their contribution to physiological stress. Published by Elsevier B.V.
C1 [Kenefick, Robert W.; Cheuvront, Samuel N.] US Army Res Inst Environm Med, Natick, MA 01760 USA.
RP Kenefick, RW (reprint author), US Army Res Inst Environm Med, Thermal & Mt Med Div, Kansas St, Natick, MA 01760 USA.
EM Robert.W.Kenefick.civ@mail.mil
NR 73
TC 1
Z9 1
U1 5
U2 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1566-0702
EI 1872-7484
J9 AUTON NEUROSCI-BASIC
JI Auton. Neurosci-Basic Clin.
PD APR
PY 2016
VL 196
SI SI
BP 47
EP 51
DI 10.1016/j.autneu.2016.02.003
PG 5
WC Neurosciences
SC Neurosciences & Neurology
GA DM0QJ
UT WOS:000376050600006
PM 26944095
ER
PT J
AU Castellani, JW
Young, AJ
AF Castellani, John W.
Young, Andrew J.
TI Human physiological responses to cold exposure: Acute responses and
acclimatization to prolonged exposure
SO AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
LA English
DT Review
DE Habituation, hypothermia; Insulative acclimatization; Shivering;
Temperature regulation; Vasoconstriction
ID AGED HUMAN SKIN; BROWN ADIPOSE-TISSUE; INDUCED CUTANEOUS
VASOCONSTRICTION; HUMAN THERMOREGULATORY RESPONSES; BASAL
METABOLIC-RATES; KOREAN WOMEN DIVERS; WATER IMMERSION; BLOOD-FLOW;
PHYSICAL-FITNESS; BODY-TEMPERATURE
AB Cold exposure in humans causes specific acute and chronic physiological responses. This paper will review both the acute and long-term physiological responses and external factors that impact these physiological responses. Acute physiological responses to cold exposure include cutaneous vasoconstriction and shivering thermogenesis which, respectively, decrease heat loss and increase metabolic heat production. Vasoconstriction is elicited through reflex and local cooling. In combination, vasoconstriction and shivering operate to maintain thermal balance when the body is losing heat. Factors (anthropometry, sex, race, fitness, thermoregulatory fatigue) that influence the acute physiological responses to cold exposure are also reviewed. The physiological responses to chronic cold exposure, also known as cold acclimation/acclimatization, are also presented. Three primary patterns of cold acclimatization have been observed, a) habituation, b) metabolic adjustment, and c) insulative adjustment. Habituation is characterized by physiological adjustments in which the response is attenuated compared to an unacclimatized state. Metabolic acclimatization is characterized by an increased thermogenesis, whereas insulative acclimatization is characterized by enhancing the mechanisms that conserve body heat. The pattern of acclimatization is dependent on changes in skin and core temperature and the exposure duration. Published by Elsevier B.V.
C1 [Castellani, John W.; Young, Andrew J.] US Army Res Inst Environm Med, Natick, MA 01760 USA.
RP Castellani, JW (reprint author), US Army Res Inst Environm Med, Thermal & Mt Med Div, 10 Gen Greene Ave, Natick, MA 01760 USA.
EM john.w.castellani.civ@mail.mil
NR 131
TC 2
Z9 2
U1 26
U2 38
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1566-0702
EI 1872-7484
J9 AUTON NEUROSCI-BASIC
JI Auton. Neurosci-Basic Clin.
PD APR
PY 2016
VL 196
SI SI
BP 63
EP 74
DI 10.1016/j.autneu.2016.02.009
PG 12
WC Neurosciences
SC Neurosciences & Neurology
GA DM0QJ
UT WOS:000376050600008
PM 26924539
ER
PT J
AU Pichugin, A
Steers, N
De la Vega, P
Zarling, S
Chalom, I
Krzych, U
AF Pichugin, Alexander
Steers, Nick
De la Vega, Patricia
Zarling, Stasya
Chalom, Isaac
Krzych, Urszula
TI TAP-mediated processing of exoerythrocytic antigens is essential for
protection induced with radiation-attenuated Plasmodium sporozoites
SO EUROPEAN JOURNAL OF IMMUNOLOGY
LA English
DT Article
DE Antigen presenting cells; CD8(+) T cells; Liver; Plasmodium; Transporter
associated with antigen processing (TAP)
ID CD8(+) T-CELLS; CLASS-I MOLECULES; MALARIA LIVER STAGES;
CIRCUMSPOROZOITE PROTEIN; CROSS-PRESENTATION; INFECTED HEPATOCYTES;
DENDRITIC CELLS; IRRADIATED SPOROZOITES; BERGHEI SPOROZOITES; PROTRACTED
PROTECTION
AB MHC class I dependent CD8(+) T cells are essential for protection induced by radiationattenuated Plasmodium sporozoites (RAS) inmurine malaria models. Apart from the mechanism of activation of CD8(+) T cells specific for the circumsporozoite protein, the major sporozoite antigen (Ag), CD8(+) T cells specific for other exoerythrocytic Ags that have been shown to mediate protection have not been thoroughly investigated. Specifically, mechanisms of processing and presentation of exoerythrocytic Ags, which includes liver stage (LS) Ags, remain poorly understood. We hypothesize that as exogenous proteins, LS Ags are processed by mechanisms involving either the TAP-dependent phagosomal-to- cytosol or TAP-independent vacuolar pathway of cross-presentation. We used TAP-deficient mice to investigate whether LS Ag mediated induction of naive CD8(+) T cells and their recall during sporozoite challenge occur by the TAP-dependent or TAP-independent pathways. On the basis of functional attributes, CD8(+) T cells were activated via the TAP-independent pathway during immunizations with Plasmodium berghei RAS; however, IFN-gamma(+) CD8(+) T cells previously induced by P. berghei RAS in TAP-deficient mice failed to be recalled against sporozoite challenge and the mice became parasitemic. On the basis of these observations, we propose that TAP-associated Ag processing is indispensable for sterile protection induced with P. berghei RAS.
C1 [Pichugin, Alexander; Steers, Nick; De la Vega, Patricia; Zarling, Stasya; Chalom, Isaac; Krzych, Urszula] Walter Reed Army Inst Res, Malaria Vaccine Branch, Dept Cellular Immunol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
RP Krzych, U (reprint author), Walter Reed Army Inst Res, Malaria Vaccine Branch, Dept Cellular Immunol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM Urszula.Krzych1.civ@mail.mil
OI Pichugin, Alexander/0000-0002-2577-7284
FU NIH [AI46438]; US Army Materiel Command
FX The authors would like to express their thanks to the members of the
Krzych lab for assistance with the experiments and helpful discussions.
We are grateful to Dr. Sofia Casares for critical reading of the
manuscript. This research was supported in part by a NIH grant AI46438
(UK) and the US Army Materiel Command. The views of the authors do not
purport to reflect the position of the Department of the Army or the
Department of Defense.
NR 65
TC 2
Z9 2
U1 0
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-2980
EI 1521-4141
J9 EUR J IMMUNOL
JI Eur. J. Immunol.
PD APR
PY 2016
VL 46
IS 4
BP 885
EP 896
DI 10.1002/eji.201545748
PG 12
WC Immunology
SC Immunology
GA DJ9SH
UT WOS:000374552700011
PM 26703789
ER
PT J
AU Holmquist, TJ
Bradley, J
Dwivedi, A
Casem, D
AF Holmquist, T. J.
Bradley, J.
Dwivedi, A.
Casem, D.
TI The response of polymethyl methacrylate (PMMA) subjected to large
strains, high strain rates, high pressures, a range in temperatures, and
variations in the intermediate principal stress
SO EUROPEAN PHYSICAL JOURNAL-SPECIAL TOPICS
LA English
DT Article
ID GLASSY-POLYMERS; BEHAVIOR; DEFORMATION; FRACTURE
AB This article presents the response of polymethyl methacrylate (PMMA) subjected to large strains, high strain rates, high pressures, a range in temperatures, and variations in the intermediate principal stress. Laboratory data from the literature, and new test data provided here, are used in the evaluation. The new data include uniaxial stress compression tests (at various strain rates and temperatures) and uniaxial stress tension tests (at low strain rates and ambient temperatures). The compression tests include experiments at I double dagger epsilon = 13,000 s(-1), significantly extending the range of known strain rate data. The observed behavior of PMMA includes the following: it is brittle in compression at high rates, and brittle in tension at all rates; strength is dependent on the pressure, strain, strain rate, temperature, and the intermediate principal stress; the shear modulus increases as the pressure increases; and it is highly compressible. Also presented are novel, high velocity impact tests (using high-speed imaging) that provide insight into the initiation and evolution of damage. Lastly, computational constitutive models for pressure, strength, and failure are presented that provide responses that are in good agreement with the laboratory data. The models are used to compute several ballistic impact events for which experimental data are available.
C1 [Holmquist, T. J.] Southwest Res Inst, Minneapolis, MN 55416 USA.
[Bradley, J.; Dwivedi, A.; Casem, D.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Holmquist, TJ (reprint author), Southwest Res Inst, Minneapolis, MN 55416 USA.
EM timothy.holmquist@swri.org
FU [W911QX-10-C-0040]
FX This work was performed for the U.S. Army Research Laboratory (ARL),
Aberdeen Proving Ground, MD under contract No. W911QX-10-C-0040. The
authors would like to thank D. Kleponis, E. Horwath, P. Patel, B. Scott
and B. Vonk for their helpful discussions and support throughout this
effort.
NR 23
TC 0
Z9 0
U1 5
U2 5
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1951-6355
EI 1951-6401
J9 EUR PHYS J-SPEC TOP
JI Eur. Phys. J.-Spec. Top.
PD APR
PY 2016
VL 225
IS 2
BP 343
EP 354
DI 10.1140/epjst/e2016-02636-5
PG 12
WC Physics, Multidisciplinary
SC Physics
GA DK0DX
UT WOS:000374583900011
ER
PT J
AU Fansiri, T
Pongsiri, A
Klungthong, C
Ponlawat, A
Thaisomboonsuk, B
Jarman, RG
Scott, TW
Lambrechts, L
AF Fansiri, Thanyalak
Pongsiri, Arissara
Klungthong, Chonticha
Ponlawat, Alongkot
Thaisomboonsuk, Butsaya
Jarman, Richard G.
Scott, Thomas W.
Lambrechts, Louis
TI No evidence for local adaptation of dengue viruses to mosquito vector
populations in Thailand
SO EVOLUTIONARY APPLICATIONS
LA English
DT Article
DE Aedes aegypti; dengue virus; genotype x genotype interactions; local
adaptation; population structure
ID AEDES-AEGYPTI POPULATIONS; KAMPHAENG-PHET; ORAL-SUSCEPTIBILITY; GLOBAL
DISTRIBUTION; CLADE REPLACEMENT; GENETIC-STRUCTURE; TRANSMISSION;
INFECTION; STRAINS; MEXICO
AB Despite their epidemiological importance, the evolutionary forces that shape the spatial structure of dengue virus genetic diversity are not fully understood. Fine-scale genetic structure of mosquito vector populations and evidence for genotype x genotype interactions between dengue viruses and their mosquito vectors are consistent with the hypothesis that the geographical distribution of dengue virus genetic diversity may reflect viral adaptation to local mosquito populations. To test this hypothesis, we measured vector competence in all sympatric and allopatric combinations of 14 low-passage dengue virus isolates and two wild-type populations of Aedes aegypti mosquitoes sampled in Bangkok and Kamphaeng Phet, two sites located about 300km apart in Thailand. Despite significant genotype x genotype interactions, we found no evidence for superior vector competence in sympatric versus allopatric vector-virus combinations. Viral phylogenetic analysis revealed no geographical clustering of the 14 isolates, suggesting that high levels of viral migration (gene flow) in Thailand may counteract spatially heterogeneous natural selection. We conclude that it is unlikely that vector-mediated selection is a major driver of dengue virus adaptive evolution at the regional scale that we examined. Dengue virus local adaptation to mosquito vector populations could happen, however, in places or times that we did not test, or at a different geographical scale.
C1 [Fansiri, Thanyalak; Pongsiri, Arissara; Ponlawat, Alongkot] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand.
[Klungthong, Chonticha; Thaisomboonsuk, Butsaya; Jarman, Richard G.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand.
[Scott, Thomas W.] Univ Calif Davis, Dept Entomol & Nematol, Davis, CA 95616 USA.
[Scott, Thomas W.] NIH, Fogarty Int Ctr, Bldg 10, Bethesda, MD 20892 USA.
[Lambrechts, Louis] Inst Pasteur, Dept Genomes & Genet, Insect Virus Interact Grp, 28 Rue Docteur Roux, F-75724 Paris 15, France.
[Lambrechts, Louis] Ctr Natl Rech Sci, Unite Rech Associee, Paris, France.
[Jarman, Richard G.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD USA.
RP Lambrechts, L (reprint author), Inst Pasteur, Dept Genomes & Genet, Insect Virus Interact Grp, 28 Rue Docteur Roux, F-75724 Paris 15, France.
EM louis.lambrechts@pasteur.fr
RI Lambrechts, Louis/A-2057-2010
OI Lambrechts, Louis/0000-0001-5958-2138
FU United States National Institutes of Health [R01-GM083224]; United
States Military Infectious Diseases Research Program; French Agence
Nationale de la Recherche [ANR-09-RPDOC-007-01]; French Government's
Investissement d'Avenir program, Laboratoire d'Excellence Integrative
Biology of Emerging Infectious Diseases [ANR-10-LABX-62-IBEID]; City of
Paris Emergence(s) program in Biomedical Research; Research and Policy
for Infectious Disease Dynamics program of the Science and Technology
Directorate, Department of Homeland Security; Fogarty International
Center, United States National Institutes of Health; United States
National Institutes of Health and Human Services [P01-AI098670]
FX We acknowledge the invaluable contributions of the clinical, laboratory,
and entomological personnel of AFRIMS and Kamphaeng Phet AFRIMS Virology
Research Unit (KAVRU). We are grateful to Robert Gibbons, Stefan
Fernandez, Timothy Endy, Anthony Schuster, and three anonymous reviewers
for their insights. The opinions or assertions contained herein are the
private views of the authors and are not to be construed as reflecting
the official views of the United States Army, Royal Thai Army, or the
United States Department of Defense. This study was primarily supported
by grant R01-GM083224 from the United States National Institutes of
Health and by the United States Military Infectious Diseases Research
Program. L.L. received funding from the French Agence Nationale de la
Recherche (grant ANR-09-RPDOC-007-01), the French Government's
Investissement d'Avenir program, Laboratoire d'Excellence Integrative
Biology of Emerging Infectious Diseases (grant ANR-10-LABX-62-IBEID),
and the City of Paris Emergence(s) program in Biomedical Research.
T.W.S. received support from the Research and Policy for Infectious
Disease Dynamics program of the Science and Technology Directorate,
Department of Homeland Security, and Fogarty International Center,
United States National Institutes of Health. L.L. and T.W.S. received
support from the United States National Institutes of Health and Human
Services (grant P01-AI098670). The funders had no role in study design,
data collection and analysis, decision to publish, or preparation of the
manuscript.
NR 47
TC 2
Z9 2
U1 1
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1752-4571
J9 EVOL APPL
JI Evol. Appl.
PD APR
PY 2016
VL 9
IS 4
BP 608
EP 618
DI 10.1111/eva.12360
PG 11
WC Evolutionary Biology
SC Evolutionary Biology
GA DJ9SM
UT WOS:000374553200007
PM 27099625
ER
PT J
AU Ernst, M
Habtour, E
Dasgupta, A
AF Ernst, Matthew
Habtour, Ed
Dasgupta, Abhijit
TI Examining Steinberg's Octave Rule Applicability for Electronic Systems
Exposed to Multiaxial Vibration
SO IEEE TRANSACTIONS ON COMPONENTS PACKAGING AND MANUFACTURING TECHNOLOGY
LA English
DT Article
DE Amplification; fatigue; multiaxial vibration; nonlinear; random;
reliability
ID PREDICTION; FATIGUE
AB This paper explores the role of nonlinear dynamical phenomena in calculating the stress amplitude in large electronic components exposed to biaxial vibration loading. Nonlinear analytical studies are presented where a component exposed to combined axial and transverse vibratory base excitation is idealized using a nonlinear structural beam element with a tip mass. Harmonic and random base vibration excitation studies are conducted. The results provided in this paper confirm that Steinberg's Octave rule may not be applicable for electronic components exposed to high amplitude multiaxial vibrations. In fact, components exposed to biaxial vibration are highly dependent on the phase angle between the orthogonal axes and the frequency ratio between the axial and transverse excitation frequencies. At critical frequency ratios, undesirable constructive and destructive stress amplification phenomena may appear if the system is exposed to a harsh multidirectional vibration environment.
C1 [Ernst, Matthew] US Air Force, Lifecycle Management Ctr, Wright Patterson AFB, OH 45433 USA.
[Habtour, Ed] US Army, Res Lab, Adelphi, MD 21005 USA.
[Dasgupta, Abhijit] Univ Maryland, Dept Mech Engn, Ctr Adv Life Cycle Engn, College Pk, MD 20742 USA.
RP Ernst, M (reprint author), US Air Force, Lifecycle Management Ctr, Wright Patterson AFB, OH 45433 USA.; Habtour, E (reprint author), US Army, Res Lab, Adelphi, MD 21005 USA.; Dasgupta, A (reprint author), Univ Maryland, Dept Mech Engn, Ctr Adv Life Cycle Engn, College Pk, MD 20742 USA.
EM ernstm@gmail.com; ed.m.habtour.civ@mail.mil; dasgupta@umd.edu
FU CALCE Consortium; TEAM Inc.; Data Physics Inc.
FX This work was supported in part by CALCE Consortium, in part by TEAM
Inc., and in part by Data Physics Inc.
NR 21
TC 0
Z9 0
U1 3
U2 3
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 2156-3950
EI 2156-3985
J9 IEEE T COMP PACK MAN
JI IEEE Trans. Compon. Pack. Manuf. Technol.
PD APR
PY 2016
VL 6
IS 4
BP 561
EP 568
DI 10.1109/TCPMT.2016.2519447
PG 8
WC Engineering, Manufacturing; Engineering, Electrical & Electronic;
Materials Science, Multidisciplinary
SC Engineering; Materials Science
GA DJ9RV
UT WOS:000374551500008
ER
PT J
AU Perotti, LP
Cummings, LD
Mercado, J
AF Perotti, Laurence P.
Cummings, Latiba D.
Mercado, Janyna
TI Behavioral Treatment of Pseudobulbar Affect: A Case Report
SO PERSPECTIVES IN PSYCHIATRIC CARE
LA English
DT Article
ID MULTIPLE-SCLEROSIS; DEXTROMETHORPHAN/QUINIDINE; MANAGEMENT
AB PURPOSE: To determine if it is possible to successfully treat pseudobulbar affect (PBA) using a behavioral approach.
DESIGN AND METHODS: Two experiments were conducted, each a double reversal design with the same single subject in both. The first experiment tested the hypothesis that the rate of PBA could be controlled by manipulation of its consequences. The second experiment tested the hypothesis that use of a self-control procedure would control the rate of PBA.
FINDINGS: Rate of PBA could not be controlled by consequence manipulation, but rate of PBA could be controlled through use of a self-control procedure.
PRACTICE IMPLICATIONS: Pending confirmatory research, behavioral interventions utilizing self-control procedures should be considered in patients with PBA.
C1 [Perotti, Laurence P.] Brooke Army Med Ctr, Multidisciplinary Clin, Dept Behav Med, San Antonio, TX USA.
[Cummings, Latiba D.] Brooke Army Med Ctr, Dept Orthoped, Brain Injury Rehabil Serv, San Antonio, TX USA.
[Mercado, Janyna] Brooke Army Med Ctr, Dept Behav Med, Neuropsychol Serv, San Antonio, TX USA.
RP Perotti, LP (reprint author), Brooke Army Med Ctr, Multidisciplinary Clin, Dept Behav Med, San Antonio, TX USA.
EM Laurence.p.perotti.civ@mail.mil
NR 20
TC 1
Z9 1
U1 0
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0031-5990
EI 1744-6163
J9 PERSPECT PSYCHIATR C
JI Perspect. Psychiatr. Care
PD APR
PY 2016
VL 52
IS 2
BP 82
EP 87
DI 10.1111/ppc.12159
PG 6
WC Nursing; Psychiatry
SC Nursing; Psychiatry
GA DK1GW
UT WOS:000374661500002
PM 27091117
ER
PT J
AU Chung, RB
Rodak, LE
Enck, RW
Sampath, AV
Wraback, M
Reed, ML
AF Chung, Roy B.
Rodak, Lee E.
Enck, Ryan W.
Sampath, Anand V.
Wraback, Michael
Reed, Meredith L.
TI Growth and impurity characterization of AlN on (0001) sapphire grown by
spatially pulsed MOCVD
SO PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE
LA English
DT Article; Proceedings Paper
CT Compound Semiconductor Week (CSW)
CY JUN 28-JUL 02, 2015
CL Santa Barbara, CA
DE AlN; impurity; MOCVD; pre-reaction; spatially pulsed growth
ID CHEMICAL-VAPOR-DEPOSITION; MOVPE
AB The reduction of undesirable gas phase reaction between trimethylaluminum and NH3 was achieved by spatially separating the precursors using N-2 purge line during AlN growth by metal organic chemical vapor deposition (MOCVD). Under this condition, it was shown that the growth pressure has a strong impact on the surface morphology independent of pre-reaction. For 0.8-mu m-thick AlN grown on (0001) sapphire substrates, increasing pressure from 200 to 500Torr drastically increased a root-mean-squared surface (r.m.s.) roughness from 0.48 to 33nm. This morphological change was previously attributed to the pre-reaction. Less pre-reaction also allowed us to investigate the pressure dependence of impurity (carbon and oxygen) incorporation in AlN as the growth rate was no longer affected by the pressure. Unlike GaN, the carbon level almost doubled with increasing pressure from 200 to 500Torr. By optimizing the surface morphology (r.m.s. roughness from 33 to 0.62nm) at 500Torr, the carbon concentration in AlN decreased from 5x10(18) to 7x10(17)cm(-3). Although there was no improvement in the structural quality, this uniquely designed MOCVD could further improve the material quality of AlN by reducing the impurity level. (C) 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
C1 [Chung, Roy B.; Rodak, Lee E.; Enck, Ryan W.; Sampath, Anand V.; Wraback, Michael; Reed, Meredith L.] US Army, Res Lab, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
RP Chung, RB (reprint author), US Army, Res Lab, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM roy.chung2.ctr@mail.mil
NR 18
TC 0
Z9 0
U1 9
U2 10
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 1862-6300
EI 1862-6319
J9 PHYS STATUS SOLIDI A
JI Phys. Status Solidi A-Appl. Mat.
PD APR
PY 2016
VL 213
IS 4
BP 851
EP 855
DI 10.1002/pssa.201532571
PG 5
WC Materials Science, Multidisciplinary; Physics, Applied; Physics,
Condensed Matter
SC Materials Science; Physics
GA DJ9VC
UT WOS:000374560100002
ER
PT J
AU Bjerkvig, CK
Strandenes, G
Eliassen, HS
Spinella, PC
Fosse, TK
Cap, AP
Ward, KR
AF Bjerkvig, Christopher K.
Strandenes, Geir
Eliassen, Hakon S.
Spinella, Philip C.
Fosse, Theodor K.
Cap, Andrew P.
Ward, Kevin R.
TI "Blood failure" time to view blood as an organ: how oxygen debt
contributes to blood failure and its implications for remote damage
control resuscitation
SO TRANSFUSION
LA English
DT Review
ID RANDOMIZED CONTROLLED-TRIAL; WHOLE-BLOOD; HEMORRHAGIC-SHOCK; TRAUMA
PATIENTS; TRANSFUSION; CELLS; MORTALITY; LACTATE; COAGULOPATHY;
PREDICTORS
AB Hemorrhagic shock is both a local and systemic disorder. In the context of systemic effects, blood loss may lead to levels of reduced oxygen delivery (DO2) sufficient to cause tissue ischemia. Similar to other physiologic debts such as sleep, it is not possible to incur a significant oxygen debt and suffer no consequences for lack of timely repayment. While the linkage between oxygen debt and traditional organ failure (renal, hepatic, lung, and circulation) has been long recognized, we should consider failure in two additional linked and very dynamic organ systems, the endothelium and blood. These systems are very sensitive to oxygen debt and at risk for failing, having further implications on all other organ systems. The degree of damage to the endothelium is largely modulated by the degree of oxygen debt. Thus hypoperfusion is believed to begin a cascade of events leading to acute traumatic coagulopathy (ATC). This combination of oxygen debt driven endothelial damage and ATC might be considered collectively as blood failure due to the highly connected networks between these drivers. This article presents the implications of oxygen debt for remote damage control resuscitation strategies, such as permissive hypotension and hemostatic resuscitation. We review the impact of whole blood resuscitation and red blood cell efficacy in mitigation of oxygen debt. At last, this article recognizes the need for simple and durable, lightweight equipment that can detect the adequacy of tissue DO2 and thus patient needs for resuscitative care. Point-of-care lactate measuring may be a predictive tool for identifying high-risk trauma patients and occult shock because it provides information beyond that of vital signs and mechanism of injury as it may help predict the level of oxygen debt accumulation and need for resuscitation. Serial measurements may also be valuable as a tool in guiding resuscitative efforts.
C1 [Bjerkvig, Christopher K.; Strandenes, Geir; Fosse, Theodor K.] Haukeland Hosp, Norwegian Naval Special Operat Command, N-5021 Bergen, Norway.
[Bjerkvig, Christopher K.; Fosse, Theodor K.] Haukeland Hosp, Dept Anesthesia & Intens Care, N-5021 Bergen, Norway.
[Strandenes, Geir; Eliassen, Hakon S.] Haukeland Hosp, Dept Immunol & Transfus Med, N-5021 Bergen, Norway.
[Spinella, Philip C.] Washington Univ, Div Pediat Crit Care, Dept Pediat, St Louis, MO USA.
[Spinella, Philip C.] US Army, Coagulat & Blood Res, Inst Surg Res, Jbsa Ft Sam Houston, TX USA.
[Ward, Kevin R.] Univ Michigan, Michigan Ctr Integrat Res Crit Care, Dept Emergency Med, Ann Arbor, MI 48109 USA.
[Cap, Andrew P.] US Army, Blood Res Program, Inst Surg Res, Ft Sam Houston, TX USA.
RP Ward, KR (reprint author), Michigan Ctr Integrat Res Crit Care, NCRC Bldg 10 Off A103,2800 Plymouth Rd, Ann Arbor, MI 48109 USA.
EM keward@umich.edu
NR 43
TC 2
Z9 2
U1 1
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0041-1132
EI 1537-2995
J9 TRANSFUSION
JI Transfusion
PD APR
PY 2016
VL 56
SU 2
SI SI
BP S182
EP S189
DI 10.1111/trf.13500
PG 8
WC Hematology
SC Hematology
GA DK1ZK
UT WOS:000374714200011
PM 27100755
ER
PT J
AU Doughty, H
Thompson, P
Cap, AP
Spinella, PC
Glassberg, E
Eliassen, HS
De Pasquale, M
Strandenes, G
AF Doughty, Heidi
Thompson, Patrick
Cap, Andrew P.
Spinella, Philip C.
Glassberg, Elon
Eliassen, Hakon Skogrand
De Pasquale, Marc
Strandenes, Geir
TI A proposed field emergency donor panel questionnaire and triage tool
SO TRANSFUSION
LA English
DT Article
ID WHOLE-BLOOD; TRANSFUSION; MANAGEMENT; GUIDELINE
AB BACKGROUND: The provision of transfusion support to isolated military or civilian projects may require the use of an emergency donor panel (EDP) for immediate warm fresh whole blood (WFWB). The aim of this short discussion article is to raise and resolve some of the practical aspects for the nonspecialist faced with the emergency collection of WFWB whole blood in the austere medical environment (AME).
METHODS AND RESULTS: A proposed field EDP questionnaire and triage tool (QTT) is presented. It is designed for the hostile, remote, or austere environment that falls outside normal regulated supply of cold-stored blood products or removed from trained blood collection personnel, where collection may fall to an isolated medical provider. The tool has been drafted based on review of existing guidelines and consultation with practitioners. It serves as a point of reference for local guidelines and has yet to be validated.
CONCLUSIONS: The use of the EDP is associated with risk; however, it remains the simplest method of providing rapid transfusion support. The best way to manage the risk is to brief and prescreen blood donors before deployment. An abbreviated donor QTT can be an aide to decision making at the time of donation. The tool should be tailored to requirements and underpinned by policy and training.
C1 [Doughty, Heidi] NHS Blood & Transplant, Birmingham B15 2SG, W Midlands, England.
[Doughty, Heidi] Queen Elizabeth Hosp, RCDM, Ctr Def Pathol, Birmingham B15 2TH, W Midlands, England.
[Thompson, Patrick] UK Paramed, THOR Network, Monmouth, Ireland.
[Cap, Andrew P.] JBSA FT, US Army Inst Surg Res, Sam Houston, TX USA.
[Glassberg, Elon] Israel Def Forces Med Corps, Ramat Gan, Israel.
[Eliassen, Hakon Skogrand] Washington Univ, Dept Pediat, Div Crit Care, St Louis, MO 63130 USA.
[Eliassen, Hakon Skogrand; Strandenes, Geir] Haukeland Hosp, Norwegian Naval Special Operat Commando, N-5021 Bergen, Norway.
[Eliassen, Hakon Skogrand; Strandenes, Geir] Haukeland Hosp, Dept Immunol & Transfus Med, N-5021 Bergen, Norway.
[De Pasquale, Marc] Independent Paramed US, THOR Network, Portland, OR USA.
RP Doughty, H (reprint author), NHS Blood & Transplant, Birmingham B15 2SG, W Midlands, England.
EM heidi.doughty@nhsbt.nhs.uk
NR 21
TC 0
Z9 0
U1 3
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0041-1132
EI 1537-2995
J9 TRANSFUSION
JI Transfusion
PD APR
PY 2016
VL 56
SU 2
SI SI
BP S119
EP S127
DI 10.1111/trf.13487
PG 9
WC Hematology
SC Hematology
GA DK1ZK
UT WOS:000374714200004
PM 27100748
ER
PT J
AU Pusateri, AE
Given, MB
Schreiber, MA
Spinella, PC
Pati, S
Kozar, RA
Khan, A
Dacorta, JA
Kupferer, KR
Prat, N
Pidcoke, HF
Macdonald, VW
Malloy, WW
Sailliol, A
Cap, AP
AF Pusateri, Anthony E.
Given, Michael B.
Schreiber, Martin A.
Spinella, Philip C.
Pati, Shibani
Kozar, Rosemary A.
Khan, Abdul
Dacorta, Joseph A.
Kupferer, Kevin R.
Prat, Nicolas
Pidcoke, Heather F.
Macdonald, Victor W.
Malloy, Wilbur W.
Sailliol, Anne
Cap, Andrew P.
TI Dried plasma: state of the science and recent developments
SO TRANSFUSION
LA English
DT Review
ID FRESH-FROZEN PLASMA; RED-BLOOD-CELLS; TRAUMA-ASSOCIATED COAGULOPATHY;
DAMAGE CONTROL RESUSCITATION; HEMORRHAGIC-SHOCK; LYOPHILIZED PLASMA;
ENDOTHELIAL GLYCOCALYX; VASCULAR-PERMEABILITY; MASSIVE TRANSFUSION;
BRAIN-INJURY
AB The early transfusion of plasma is important to ensure optimal survival of patients with traumatic hemorrhage. In military and remote or austere civilian settings, it may be impossible to move patients to hospital facilities within the first few hours of injury. A dried plasma product with reduced logistical requirements is needed to enable plasma transfusion where medically needed, instead of only where freezers and other equipment are available. First developed in the 1930s, pooled lyophilized plasma was widely used by British and American forces in WWII and the Korean War. Historical dried plasma products solved the logistical problem but were abandoned because of disease transmission. Modern methods to improve blood safety have made it possible to produce safe and effective dried plasma. Dried plasma products are available in France, Germany, South Africa, and a limited number of other countries. However, no product is available in the US. Promising products are in development that employ different methods of drying, pathogen reduction, pooling, packaging, and other approaches. Although challenges exist, the in vitro and in vivo data suggest that these products have great potential to be safe and effective. The history, state of the science, and recent developments in dried plasma are reviewed.
C1 [Pusateri, Anthony E.] US Army, Med Res & Mat Command, 504 Scott St,Bldg 722, Ft Detrick, MD 21702 USA.
[Given, Michael B.] Off Naval Res, Arlington, VA 22217 USA.
[Schreiber, Martin A.] Oregon Hlth & Sci Univ, Portland, OR 97201 USA.
[Spinella, Philip C.] Washington Univ, St Louis, MO 63130 USA.
[Pati, Shibani] Blood Syst Res Inst, San Francisco, CA USA.
[Kozar, Rosemary A.] Univ Maryland, Sch Med, Baltimore, MD 21201 USA.
[Khan, Abdul] Velico Med Inc, Beverly, MA USA.
[Dacorta, Joseph A.] Entegrion Inc, Res Triangle Pk, NC USA.
[Kupferer, Kevin R.] Air Force Med Support Agcy, Falls Church, VA USA.
[Prat, Nicolas] French Armed Forces Inst Biomed Res IRBA Bretigny, Marseille, France.
[Pidcoke, Heather F.; Cap, Andrew P.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Macdonald, Victor W.] US Army, Med Res & Mat Command, Med Mat Dev Act, 504 Scott St,Bldg 722, Ft Detrick, MD 21702 USA.
[Malloy, Wilbur W.] US Army, Med Res & Mat Command, Congressionally Directed Med Res Programs, 504 Scott St,Bldg 722, Ft Detrick, MD 21702 USA.
[Sailliol, Anne] Ctr Transfus Sanguine Armees, Clamart, France.
RP Pusateri, AE (reprint author), US Army, Med Res & Mat Command, Combat Casualty Care Res Program, 504 Scott St,Bldg 722, Ft Detrick, MD 21702 USA.
EM anthony.e.pusateri.civ@mail.mil
RI PRAT, Nicolas/R-4213-2016
NR 68
TC 2
Z9 2
U1 2
U2 6
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0041-1132
EI 1537-2995
J9 TRANSFUSION
JI Transfusion
PD APR
PY 2016
VL 56
SU 2
SI SI
BP S128
EP S139
DI 10.1111/trf.13580
PG 12
WC Hematology
SC Hematology
GA DK1ZK
UT WOS:000374714200005
PM 27100749
ER
PT J
AU Spinella, PC
Pidcoke, HF
Strandenes, G
Hervig, T
Fisher, A
Jenkins, D
Yazer, M
Stubbs, J
Murdock, A
Sailliol, A
Ness, PM
Cap, AP
AF Spinella, Philip C.
Pidcoke, Heather F.
Strandenes, Geir
Hervig, Tor
Fisher, Andrew
Jenkins, Donald
Yazer, Mark
Stubbs, James
Murdock, Alan
Sailliol, Anne
Ness, Paul M.
Cap, Andrew P.
TI Whole blood for hemostatic resuscitation of major bleeding
SO TRANSFUSION
LA English
DT Review
ID DAMAGE CONTROL RESUSCITATION; VERSUS-HOST-DISEASE; FRESH-FROZEN PLASMA;
IN-VITRO; FLUID RESUSCITATION; PLATELET-AGGREGATION;
EXTRACELLULAR-MATRIX; TRAUMA RESUSCITATION; TRANSFUSION POLICIES;
APHERESIS PLATELETS
AB Recent combat experience reignited interest in transfusing whole blood (WB) for patients with life-threatening bleeding. US Army data indicate that WB transfusion is associated with improved or comparable survival compared to resuscitation with blood components. These data complement randomized controlled trials that indicate that platelet (PLT)-containing blood products stored at 4 degrees C have superior hemostatic function, based on reduced bleeding and improved functional measures of hemostasis, compared to PLT-containing blood products at 22 degrees C. WB is rarely available in civilian hospitals and as a result is rarely transfused for patients with hemorrhagic shock. Recent developments suggest that impediments to WB availability can be overcome, specifically the misconceptions that WB must be ABO specific, that WB cannot be leukoreduced and maintain PLTs, and finally that cold storage causes loss of PLT function. Data indicate that the use of low anti-A and anti-B titer group O WB is safe as a universal donor, WB can be leukoreduced with PLT-sparing filters, and WB stored at 4 degrees C retains PLT function during 15 days of storage. The understanding that these perceived barriers are not insurmountable will improve the availability of WB and facilitate its use. In addition, there are logistic and economic advantages of WB-based resuscitation compared to component therapy for hemorrhagic shock. The use of low-titer group O WB stored for up to 15 days at 4 degrees C merits further study to compare its efficacy and safety with current resuscitation approaches for all patients with life-threatening bleeding.
C1 [Spinella, Philip C.] Washington Univ, Dept Pediat, Div Crit Care, St Louis, MO 63110 USA.
[Spinella, Philip C.; Pidcoke, Heather F.; Cap, Andrew P.] US Army, Inst Surg Res, Jbsa Ft Sam Houston, TX USA.
[Strandenes, Geir] Norwegian Naval Special Operat Commando, Bergen, Norway.
[Strandenes, Geir; Hervig, Tor] Haukeland Hosp, Dept Immunol & Transfus Med, N-5021 Bergen, Norway.
[Fisher, Andrew] 75th Ranger Regiment, Ft Benning, GA USA.
[Jenkins, Donald] Mayo Clin, Dept Surg, Coll Med, Med Director,Trauma Ctr, Rochester, MN USA.
[Stubbs, James] Mayo Clin, Dept Lab Med & Pathol, Div Transfus Med, Rochester, MN USA.
[Yazer, Mark] Univ Pittsburgh, Dept Pathol, Pittsburgh, PA USA.
[Yazer, Mark] Inst Transfus Med, Pittsburgh, PA USA.
[Murdock, Alan] Univ Pittsburgh, Dept Surg, Pittsburgh, PA USA.
[Murdock, Alan] Allegheny Gen Hosp, Div Trauma, Pittsburgh, PA 15212 USA.
[Sailliol, Anne] French Mil Blood Transfus Ctr, Clamart, France.
[Ness, Paul M.] Johns Hopkins Med Inst, Transfus Med Div, Dept Pathol, Baltimore, MD 21205 USA.
RP Spinella, PC (reprint author), Washington Univ, Dept Pediat, Div Crit Care, St Louis, MO 63110 USA.
EM Spinella_P@kids.wustl.edu
RI Fisher, Andrew/M-8683-2015
OI Fisher, Andrew/0000-0003-1994-7774
NR 77
TC 3
Z9 3
U1 2
U2 6
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0041-1132
EI 1537-2995
J9 TRANSFUSION
JI Transfusion
PD APR
PY 2016
VL 56
SU 2
SI SI
BP S190
EP S202
DI 10.1111/trf.13491
PG 13
WC Hematology
SC Hematology
GA DK1ZK
UT WOS:000374714200012
PM 27100756
ER
PT J
AU Woolley, T
Badloe, J
Bohonek, M
Taylor, AL
Heier, HE
Doughty, H
AF Woolley, Tom
Badloe, John
Bohonek, Milos
Taylor, Audra L.
Heier, Hans Erik
Doughty, Heidi
TI NATO Blood Panel perspectives on changes to military prehospital
resuscitation policies: current and future practice
SO TRANSFUSION
LA English
DT Article
ID FRESH WHOLE-BLOOD; COMBAT CASUALTIES; IMPROVED SURVIVAL; TRANEXAMIC
ACID; TRAUMA PATIENTS; TRANSFUSION; AFGHANISTAN; PLASMA; PLATELETS;
TRIAL
AB The North Atlantic Treaty Organization (NATO) Blood Panel exists to promote interoperability of transfusion practice between NATO partners. However, it has served as an important forum for the development of prehospital transfusion and transfusion in the austere environment. There are synergies with the trauma hemostasis and oxygen research community especially in the areas of innovation and research. Four presentations are summarized together with a review of some scientific principles. The past decade has already seen significant changes in early transfusion support. Sometimes practice has preceded the evidence and has stretched regulatory and logistic constraints. Ethical and philosophical issues are also important and require us to question should we and not just could we. The challenge for the combined communities is to continue to optimize transfusion support underpinned by evidence-based excellence.
C1 [Woolley, Tom] Royal Ctr Def Med, Dept Mil Anaesthesia & Crit Care, Birmingham, W Midlands, England.
[Badloe, John] SBB ASCP, Netherlands Mil Blood Bank, Consultant Transfus Med, Amsterdam, Netherlands.
[Bohonek, Milos] Army Czech Republ, Mil Med Serv, Main Consultant Hematol & Blood Transfus, Prague, Czech Republic.
[Taylor, Audra L.] US Army, Blood Program, Jbsa Ft Sam Houston, TX USA.
[Heier, Hans Erik] Norwegian Mil Med Serv, Oslo, Norway.
[Doughty, Heidi] NHS Blood & Transplant, Birmingham, W Midlands, England.
[Doughty, Heidi] Queen Elizabeth Hosp, Ctr Def Pathol, RCDM, Birmingham B15 2TH, W Midlands, England.
RP Woolley, T (reprint author), RCDM, ICT Ctr, Birmingham Res Pk, Birmingham B15 2SQ, W Midlands, England.
EM t.woolley@nhs.net
NR 26
TC 0
Z9 0
U1 1
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0041-1132
EI 1537-2995
J9 TRANSFUSION
JI Transfusion
PD APR
PY 2016
VL 56
SU 2
SI SI
BP S217
EP S223
DI 10.1111/trf.13489
PG 7
WC Hematology
SC Hematology
GA DK1ZK
UT WOS:000374714200015
PM 27100759
ER
PT J
AU Hoge, CW
Ivany, CG
Brusher, EA
Brown, MD
Shero, JC
Adler, AB
Warner, CH
Orman, DT
AF Hoge, Charles W.
Ivany, Christopher G.
Brusher, Edward A.
Brown, Millard D., III
Shero, John C.
Adler, Amy B.
Warner, Christopher H.
Orman, David T.
TI Transformation of Mental Health Care for US Soldiers and Families During
the Iraq and Afghanistan Wars: Where Science and Politics Intersect
SO AMERICAN JOURNAL OF PSYCHIATRY
LA English
DT Review
ID POSTTRAUMATIC-STRESS-DISORDER; TRAUMATIC BRAIN-INJURY; MILITARY
PERSONNEL; COMBAT DEPLOYMENT; FUNCTIONAL IMPAIRMENT; PTSD CHECKLIST;
SYMPTOMS; PREVALENCE; RANDOMIZATION; POPULATION
AB The cumulative strain of 14 years of war on service members, veterans, and their families, together with continuing global threats and the unique stresses of military service, are likely to be felt for years to come. Scientific as well as political factors have influenced how the military has addressed the mental health needs resulting from these wars. Two important differences between mental health care delivered during the Iraq and Afghanistan wars and previous wars are the degree to which research has directly informed care and the consolidated management of services. The U.S. Army Medical Command implemented programmatic changes to ensure delivery of high-quality standardized mental health services, including centralized workload management; consolidation of psychiatry, psychology, psychiatric nursing, and social work services under integrated behavioral health departments; creation of satellite mental health clinics embedded within brigade work areas; incorporation of mental health providers into primary care; routine mental health screening throughout soldiers' careers; standardization of clinical outcome measures; and improved services for family members. This transformation has been accompanied by reduction in psychiatric hospitalizations and improved continuity of care. Challenges remain, however, including continued underutilization of services by those most in need, problems with treatment of substance use disorders, overuse of opioid medications, concerns with the structure of care for chronic post-deployment (including postconcussion) symptoms, and ongoing questions concerning the causes of historically high suicide rates, efficacy of resilience training initiatives, and research priorities. It is critical to ensure that remaining gaps are addressed and that knowledge gained during these wars is retained and further evolved.
C1 [Hoge, Charles W.] Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Silver Spring, MD USA.
Off Army Surg Gen, Behav Hlth Div, Falls Church, VA USA.
US Army Med Command Headquarters, Behav Hlth Div, Ft Sam Houston, TX USA.
Extrem Trauma & Amputat Ctr Excellence, Dept Def & Vet Affairs, Ft Sam Houston, TX USA.
61st Multifunct Med Battal, Ft Hood, TX USA.
RP Hoge, CW (reprint author), Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Silver Spring, MD USA.
EM charles.w.hoge.civ@mail.mil
NR 66
TC 4
Z9 4
U1 4
U2 14
PU AMER PSYCHIATRIC PUBLISHING, INC
PI ARLINGTON
PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA
SN 0002-953X
EI 1535-7228
J9 AM J PSYCHIAT
JI Am. J. Psychiat.
PD APR
PY 2016
VL 173
IS 4
BP 334
EP 343
DI 10.1176/appi.ajp.2015.15040553
PG 10
WC Psychiatry
SC Psychiatry
GA DK9ZH
UT WOS:000375290400009
PM 26552941
ER
PT J
AU Johnson, KA
Dalzell, BJ
Donahue, M
Gourevitch, J
Johnson, DL
Karlovits, GS
Keeler, B
Smith, JT
AF Johnson, Kris A.
Dalzell, Brent J.
Donahue, Marie
Gourevitch, Jesse
Johnson, Dennis L.
Karlovits, Greg S.
Keeler, Bonnie
Smith, Jason T.
TI Conservation Reserve Program (CRP) lands provide ecosystem service
benefits that exceed land rental payment costs
SO ECOSYSTEM SERVICES
LA English
DT Article
DE Agriculture; Conservation reserve program; Ecosystem services;
Cost-benefit analysis; Water quality; Valuation
ID PRAIRIE POTHOLE REGION; WILLINGNESS-TO-PAY; WATER-QUALITY;
DRINKING-WATER; NITROGEN-CYCLE; UNITED-STATES; NITRATE; VALUATION;
EMISSIONS; OPPORTUNITIES
AB Global demand for commodities prompted the expansion of row crop agriculture in the Upper Midwest, USA with unknown consequences for multiple ecosystem services. The Conservation Reserve Program (CRP) was designed to protect these services by paying farmers to retire environmentally sensitive land. Here we assessed whether the benefits provided by CRP's targeted retirement of agricultural land are equal to or greater in value than the cost of rental payments to farmers. We quantified the benefits of CRP lands for reducing flood damages, improving water quality and air-quality, and contributing to green-house gas mitigation in the Indian Creek watershed in Iowa. We found that for all assessed scenarios of CRP implementation, the ecosystem service benefits provided by CRP lands exceed the cost of payments to farmers. Expanding CRP implementation under one of three potential scenarios would require an average per-acre payment of $1311 over the life of a 10-year contract but would generate benefits with a net present value of between $1710 and $6401. This analysis suggests that investment in CRP in Indian Creek, and likely in other watersheds in the Upper Midwest, is justified based upon the value of public and private benefits provided by CRP lands. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Johnson, Kris A.] Nature Conservancy, 1101 West River Pkwy,Suite 200, Minneapolis, MN 55415 USA.
[Dalzell, Brent J.] Univ Minnesota, Dept Soil Water & Climate, St Paul, MN 55108 USA.
[Donahue, Marie; Gourevitch, Jesse; Keeler, Bonnie] Univ Minnesota, Inst Environm, St Paul, MN 55108 USA.
[Johnson, Dennis L.] US Army Corps Engineers, Econ & Environm Anal Branch, Mississippi Valley Div, Rock Isl, IL USA.
[Karlovits, Greg S.] US Army Corps Engineers, Mississippi Valley Div, Rock Isl, IL USA.
[Smith, Jason T.] US Army Corps Engineers, Reg Planning & Environm Div, Mississippi Valley Div, Rock Isl, IL USA.
RP Johnson, KA (reprint author), Nature Conservancy, 1101 West River Pkwy,Suite 200, Minneapolis, MN 55415 USA.
EM kjohnson@tnc.org
FU USDA [F14AP00712]; The Nature Conservancy; US Fish and Wildlife Service
Landscape Conservation Cooperatives program
FX We would like to acknowledge the USDA (Grant no. F14AP00712)-Farm
Service Agency for sharing baseline information about CRP lands in
Indian Creek. We also thank USGS for sharing an initial SWAT model for
the Cedar Basin and the Iowa Soybean Association for providing data to
assist with hydrologic model calibration and validation. In addition, we
thank Elise De-Buysser for assistance with literature reviews, Lance Le
of the University of Iowa IIHR for sharing precipitation data and the IA
Department of Natural Resources GIS Library and the Linn County GIS
Office for sharing GIS data. J Fargione, P Kareiva, and M Miller
provided helpful reviews on earlier drafts of this manuscript. This
research was made possible by the McKnight Foundation's generous support
of The Nature Conservancy and additional support was provided by a grant
from the US Fish and Wildlife Service Landscape Conservation
Cooperatives program.
NR 81
TC 0
Z9 0
U1 11
U2 22
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 2212-0416
J9 ECOSYST SERV
JI Ecosyst. Serv.
PD APR
PY 2016
VL 18
BP 175
EP 185
DI 10.1016/j.ecoser.2016.03.004
PG 11
WC Ecology; Environmental Sciences; Environmental Studies
SC Environmental Sciences & Ecology
GA DK8XV
UT WOS:000375213800016
ER
PT J
AU Tolisano, AM
Klem, C
Lustik, MB
Sniezek, JC
Golden, JB
AF Tolisano, Anthony M.
Klem, Christopher
Lustik, Michael B.
Sniezek, Joseph C.
Golden, J. Blake
TI Effect of a second primary thyroid carcinoma on patients with head and
neck squamous cell carcinoma
SO HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND
NECK
LA English
DT Article
DE thyroid cancer; second primary malignancy; head and neck squamous cell
carcinoma; Surveillance, Epidemiology, and End Results (SEER); survival
ID LUNG-CANCER
AB Background. The purpose of this study was to characterize the timing, histology, and behavior of second primary thyroid carcinoma (SPTC) developing after a diagnosis of head and neck squamous cell carcinoma (HNSCC).
Methods. We conducted a retrospective review of the Surveillance, Epidemiology, and End Results (SEER) 9 database.
Results. Patients with HNSCC who develop SPTC die 1.6 times sooner than those without SPTC. This effect is only seen if SPTC presents >6 months after diagnosis of HNSCC. Models were adjusted for age, sex, year of diagnosis, and location of HNSCC. There was no effect of prior radiation therapy on either mortality rates or time to development of thyroid cancer in patients with SPTC. The type of thyroid carcinoma that developed was similar between cohorts.
Conclusion. The development of SPTC in patients with HNSCC results in decreased overall length of survival. (c) 2015 Wiley Periodicals, Inc.
C1 [Tolisano, Anthony M.; Klem, Christopher; Golden, J. Blake] Tripler Army Med Ctr, Dept Otolaryngol, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
[Lustik, Michael B.] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA.
[Sniezek, Joseph C.] Swedish Canc Inst, Div Head & Neck Surg, Seattle, WA USA.
RP Tolisano, AM (reprint author), Tripler Army Med Ctr, Dept Otolaryngol, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM anthony.tolisano@gmail.com
NR 14
TC 0
Z9 0
U1 1
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1043-3074
EI 1097-0347
J9 HEAD NECK-J SCI SPEC
JI Head Neck-J. Sci. Spec. Head Neck
PD APR
PY 2016
VL 38
SU 1
BP E890
EP E894
DI 10.1002/hed.24121
PG 5
WC Otorhinolaryngology; Surgery
SC Otorhinolaryngology; Surgery
GA DK7OU
UT WOS:000375116400108
PM 25965105
ER
PT J
AU DeGregorio, BA
Weatherhead, PJ
Sperry, JH
AF DeGregorio, Brett A.
Weatherhead, Patrick J.
Sperry, Jinelle H.
TI ECOLOGY AND PREDATION BEHAVIOR OF CORN SNAKES (PANTHEROPHIS GUTTATUS) ON
AVIAN NESTS
SO HERPETOLOGICAL CONSERVATION AND BIOLOGY
LA English
DT Article
DE activity patterns; behavior; Black Racers; Corn Snakes; edge effects;
nest predation; Ratsnakes
ID GOLDEN-CHEEKED WARBLER; SONGBIRD NESTS; VIDEO IDENTIFICATION;
SEASONAL-VARIATION; RAT SNAKE; HABITAT; BIRDS; LOCATION; PATTERNS;
SURVIVAL
AB Relatively little is known about the ecology of free-ranging Corn Snakes (Pantherophis guttatus), although they have been implicated as regionally important avian nest predators. We used nest camera data from 97 snake predation events, 25% of which were attributable to Corn Snakes, to assess how the ecology and behavior of nest predation by Corn Snakes compares to that of sympatric snakes that predate nests. Unlike Ratsnakes (P. alleghaniensis) and Racers (Coluber constrictor), Corn Snakes more frequently preyed on nests located away from forest edges. Nest predation by Corn Snakes, like that by Ratsnakes and Racers, increased over the nesting season. Of the four snake species documented preying on nests at our site, Corn Snakes were the only exclusively nocturnal nest predator, arriving at nests between 2024 and 0220. Corn Snakes were nearly five times more likely to prey on nestlings than eggs, suggesting that they may locate nests visually during the day. On four occasions Corn Snakes arrived at nests shortly after or while other snakes preyed on nestlings, indicating that Corn Snakes may use cues provided by other snakes to locate prey. Unlike other snake species, Corn Snakes never struck at adult birds on the nest and often actually pushed sleeping adults off the nest or pushed under them to access nestlings. Although Corn Snakes do not appear to present nesting birds with unique challenges for avoiding predation, Corn Snakes do present researchers with intriguing questions about their foraging behavior.
C1 [DeGregorio, Brett A.; Weatherhead, Patrick J.; Sperry, Jinelle H.] Univ Illinois, Dept Nat Resources & Environm Sci, 1102 S Goodwin Dr, Urbana, IL 61801 USA.
[DeGregorio, Brett A.; Sperry, Jinelle H.] US Army Corps Engineers, ERDC CERL, 2902 Newmark Dr, Champaign, IL 61821 USA.
RP DeGregorio, BA (reprint author), Univ Illinois, Dept Nat Resources & Environm Sci, 1102 S Goodwin Dr, Urbana, IL 61801 USA.
EM badegregorio@gmail.com
FU Construction Engineering Research Laboratory of the Engineer Research
Development Center; Tim Hayden
FX Funding was provided by the Construction Engineering Research Laboratory
of the Engineer Research Development Center. We thank Tim Hayden for
arranging funding. Special thanks to the Savannah River Ecology Lab for
hosting us, particularly Tracey Tuberville and Brian Metts. We thank all
of our technicians including Eric Nordberg, Mary Mack Gray, Ashley
Smith, Patrick Barnhart, Patrick Roberts, Phil Vogrinc, Emily Williams,
Mae Cowgill, Sara Wendt, Clay Noss, and Andrew Cronin. We thank Scott
Chiavacci for assistance with nest cameras and Kirk Stodola for his
statistical assistance. We also thank Dr. Jason Norman and the Hammond
Hills Animal Hospital for transmitter surgeries. Animals were collected
under SC Department of Natural Resources permits # G-11-03 and 23-2012A.
Animal procedures conformed to permits approved by the Universities of
Illinois (IACUC # 11054) and Georgia (AUP # A2011 04-007-Y2-A0).
NR 31
TC 0
Z9 0
U1 11
U2 14
PU HERPETOLOGICAL CONSERVATION & BIOLOGY
PI CORVALLIS
PA C/O R BRUCE BURY, USGS FOREST & RANGELAND, CORVALLIS, OR 00000 USA
SN 2151-0733
EI 1931-7603
J9 HERPETOL CONSERV BIO
JI Herpetol. Conserv. Biol.
PD APR
PY 2016
VL 11
IS 1
BP 150
EP 159
PG 10
WC Zoology
SC Zoology
GA DK9LL
UT WOS:000375251800017
ER
PT J
AU Hong, HX
Shen, J
Ng, HW
Sakkiah, S
Ye, H
Ge, WG
Gong, P
Xiao, WM
Tong, WD
AF Hong, Huixiao
Shen, Jie
Ng, Hui Wen
Sakkiah, Sugunadevi
Ye, Hao
Ge, Weigong
Gong, Ping
Xiao, Wenming
Tong, Weida
TI A Rat alpha-Fetoprotein Binding Activity Prediction Model to Facilitate
Assessment of the Endocrine Disruption Potential of Environmental
Chemicals
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE model; prediction; alpha-fetoprotein; endocrine; disruption; binding;
assessment
ID ANDROGEN RECEPTOR ANTAGONISTS; HUMAN-IMMUNODEFICIENCY-VIRUS; HIV-1
INTEGRASE INHIBITORS; ESTROGEN-RECEPTOR; STRUCTURE ELUCIDATION; DECISION
FOREST; EXPERT-SYSTEM; MOLECULAR DOCKING; CYTOCHROME-P450 CYP3A4;
4-POINT PHARMACOPHORE
AB Endocrine disruptors such as polychlorinated biphenyls (PCBs), diethylstilbestrol (DES) and dichlorodiphenyltrichloroethane (DDT) are agents that interfere with the endocrine system and cause adverse health effects. Huge public health concern about endocrine disruptors has arisen. One of the mechanisms of endocrine disruption is through binding of endocrine disruptors with the hormone receptors in the target cells. Entrance of endocrine disruptors into target cells is the precondition of endocrine disruption. The binding capability of a chemical with proteins in the blood affects its entrance into the target cells and, thus, is very informative for the assessment of potential endocrine disruption of chemicals. alpha-fetoprotein is one of the major serum proteins that binds to a variety of chemicals such as estrogens. To better facilitate assessment of endocrine disruption of environmental chemicals, we developed a model for -fetoprotein binding activity prediction using the novel pattern recognition method (Decision Forest) and the molecular descriptors calculated from two-dimensional structures by Mold(2) software. The predictive capability of the model has been evaluated through internal validation using 125 training chemicals (average balanced accuracy of 69%) and external validations using 22 chemicals (balanced accuracy of 71%). Prediction confidence analysis revealed the model performed much better at high prediction confidence. Our results indicate that the model is useful (when predictions are in high confidence) in endocrine disruption risk assessment of environmental chemicals though improvement by increasing number of training chemicals is needed.
C1 [Hong, Huixiao; Shen, Jie; Ng, Hui Wen; Sakkiah, Sugunadevi; Ye, Hao; Ge, Weigong; Xiao, Wenming; Tong, Weida] US FDA, Natl Ctr Toxicol Res, Div Bioinformat & Biostat, Jefferson, AR 72079 USA.
[Gong, Ping] US Army, Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
RP Hong, HX (reprint author), US FDA, Natl Ctr Toxicol Res, Div Bioinformat & Biostat, Jefferson, AR 72079 USA.
EM Huixiao.Hong@fda.hhs.gov; jieeshen@gmail.com; Huiwen.Ng@fda.hhs.gov;
Suguna.Sakkiah@fda.hhs.gov; haoye.ecust@gmail.com;
weigong.ge@fda.hhs.gov; Ping.Gong@usace.army.mil;
Wenming.Xiao@fda.hhs.gov; Weida.Tong@fda.hhs.gov
OI Sakkiah, Suguna Devi/0000-0002-8337-9348
NR 81
TC 2
Z9 2
U1 5
U2 11
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD APR
PY 2016
VL 13
IS 4
AR 372
DI 10.3390/ijerph13040372
PG 18
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA DK9DR
UT WOS:000375231300020
PM 27023588
ER
PT J
AU Fellin, RE
Seay, JF
Gregorczyk, KN
Hasselquist, L
AF Fellin, Rebecca E.
Seay, Joseph F.
Gregorczyk, Karen N.
Hasselquist, Leif
TI Spatiotemporal Parameters are not Substantially Influenced by Load
Carriage or Inclination During Treadmill and Overground Walking
SO JOURNAL OF HUMAN KINETICS
LA English
DT Article
DE gait; uphill; downhill; external load
ID GAIT; BIOMECHANICS; SURFACES; SLOPE
AB Influences of load carriage and inclination on spatiotemporal parameters were examined during treadmill and overground walking. Ten soldiers walked on a treadmill and overground with three load conditions (00 kg, 20 kg, 40 kg) during level, uphill (6% grade) and downhill (-6% grade) inclinations at self-selected speed, which was constant across conditions. Mean values and standard deviations for double support percentage, stride length and a step rate were compared across conditions. Double support percentage increased with load and inclination change from uphill to level walking, with a 0.4% stance greater increase at the 20 kg condition compared to 00 kg. As inclination changed from uphill to downhill, the step rate increased more overground (4.3 +/- 3.5 steps/min) than during treadmill walking (1.7 +/- 2.3 steps/min). For the 40 kg condition, the standard deviations were larger than the 00 kg condition for both the step rate and double support percentage. There was no change between modes for step rate standard deviation. For overground compared to treadmill walking, standard deviation for stride length and double support percentage increased and decreased, respectively. Changes in the load of up to 40 kg, inclination of 6% grade away from the level (i.e., uphill or downhill) and mode (treadmill and overground) produced small, yet statistically significant changes in spatiotemporal parameters. Variability, as assessed by standard deviation, was not systematically lower during treadmill walking compared to overground walking. Due to the small magnitude of changes, treadmill walking appears to replicate the spatiotemporal parameters of overground walking.
C1 [Fellin, Rebecca E.; Seay, Joseph F.] US Army, Environm Med Res Inst, Mil Performance Div, 10 Gen Greene Ave,Bldg 42, Natick, MA 01760 USA.
[Gregorczyk, Karen N.; Hasselquist, Leif] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA USA.
RP Fellin, RE (reprint author), US Army, Environm Med Res Inst, Mil Performance Div, 10 Gen Greene Ave,Bldg 42, Natick, MA 01760 USA.
EM rebecca.e.fellin.civ@mail.mil
FU United States Army Research Institute of Environmental Medicine
FX The authors thank Shane Sauer for data processing assistance as well as
Carolyn K. Bensel and Jeffrey M. Schiffman for study design and
implementation assistance. The authors are all employees of the
Department of Defense in the United States Government. Research was
supported in part by an appointment (R.E.F.) to the Postgraduate
Research Participation Program funded by the United States Army Research
Institute of Environmental Medicine & administered by the Oak Ridge
Institute for Science and Engineering. Funding sources had no role in
the study design; in the collection, analysis and interpretation of
data; in the writing of the report; and in the decision to submit the
article for publication. Some of the results were published in the
abstract form at the Annual Meeting of the American Society of
Biomechanics in 2012.
NR 20
TC 0
Z9 0
U1 2
U2 2
PU DE GRUYTER OPEN LTD
PI WARSAW
PA BOGUMILA ZUGA 32A ST, 01-811 WARSAW, POLAND
SN 1640-5544
EI 1899-7562
J9 J HUM KINET
JI J. Hum. Kinet.
PD APR
PY 2016
VL 50
IS 1
BP 27
EP 35
DI 10.1515/hukin-2015-0138
PG 9
WC Sport Sciences
SC Sport Sciences
GA DK5TI
UT WOS:000374983000003
PM 28149338
ER
PT J
AU Golden, JW
Maes, P
Kwilas, SA
Ballantyne, J
Hooper, JW
AF Golden, Joseph W.
Maes, Piet
Kwilas, Steven A.
Ballantyne, John
Hooper, Jay W.
TI Glycoprotein-Specific Antibodies Produced by DNA Vaccination Protect
Guinea Pigs from Lethal Argentine and Venezuelan Hemorrhagic Fever
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID LYMPHOCYTIC CHORIOMENINGITIS VIRUS; PULMONARY SYNDROME HPS; JUNIN VIRUS;
MONOCLONAL-ANTIBODIES; LASSA-VIRUS; NEUTRALIZING ANTIBODY; ENVELOPE
GLYCOPROTEIN; NONHUMAN-PRIMATES; CROSS-REACTIVITY; IMMUNE PLASMA
AB Several members of the Arenaviridae can cause acute febrile diseases in humans, often resulting in lethality. The use of convalescent-phase human plasma is an effective treatment in humans infected with arenaviruses, particularly species found in South America. Despite this, little work has focused on developing potent and defined immunotherapeutics against arenaviruses. In the present study, we produced arenavirus neutralizing antibodies by DNA vaccination of rabbits with plasmids encoding the full-length glycoprotein precursors of Junin virus (JUNV), Machupo virus (MACV), and Guanarito virus (GTOV). Geometric mean neutralizing antibody titers, as measured by the 50% plaque reduction neutralization test (PRNT50), exceeded 5,000 against homologous viruses. Antisera against each targeted virus exhibited limited cross-species binding and, to a lesser extent, cross-neutralization. Anti-JUNV glycoprotein rabbit antiserum protected Hartley guinea pigs from lethal intraperitoneal infection with JUNV strain Romero when the antiserum was administered 2 days after challenge and provided some protection (similar to 30%) when administered 4 days after challenge. Treatment starting on day 6 did not protect animals. We further formulated an IgG antibody cocktail by combining anti-JUNV, -MACV, and -GTOV antibodies produced in DNA-vaccinated rabbits. This cocktail protected 100% of guinea pigs against JUNV and GTOV lethal disease. We then expanded on this cocktail approach by simultaneously vaccinating rabbits with a combination of plasmids encoding glycoproteins from JUNV, MACV, GTOV, and Sabia virus (SABV). Sera collected from rabbits vaccinated with the combination vaccine neutralized all four targets. These findings support the concept of using a DNA vaccine approach to generate a potent pan-arenavirus immunotherapeutic.
C1 [Golden, Joseph W.; Kwilas, Steven A.; Hooper, Jay W.] US Army, Med Res Inst Infect Dis, Dept Mol Virol, Div Virol, Ft Detrick, MD 21702 USA.
[Maes, Piet] Katholieke Univ Leuven, Rega Inst Med Res, Dept Microbiol & Immunol, Lab Clin & Epidemiol Virol, Leuven, Belgium.
[Ballantyne, John] Aldevron LLC, Fargo, ND USA.
RP Hooper, JW (reprint author), US Army, Med Res Inst Infect Dis, Dept Mol Virol, Div Virol, Ft Detrick, MD 21702 USA.
EM jay.w.hooper.civ@mail.mil
OI Hooper, Jay/0000-0002-4475-0415
FU Joint Program Executive Office for Chemical and Biological Defense,
Chemical Biological Medical Systems [W9113M-08-1-0008]; Military
Infectious Disease Research Program; Army for Acquisition, Logistics,
and Technology
FX The Joint Program Executive Office for Chemical and Biological Defense,
Chemical Biological Medical Systems, provided funding to John Ballantyne
under grant number W9113M-08-1-0008. The Military Infectious Disease
Research Program provided a Program Area T grant to Joseph W. Golden,
Piet Maes, Steven A. Kwilas, and Jay W. Hooper. The Assistant Secretary
of the Army for Acquisition, Logistics, and Technology provided an
In-House Laboratory Independent Research grant to Joseph W. Golden. The
funders had no role in study design, data collection and interpretation,
or the decision to submit the work for publication.
NR 61
TC 1
Z9 1
U1 2
U2 3
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0022-538X
EI 1098-5514
J9 J VIROL
JI J. Virol.
PD APR
PY 2016
VL 90
IS 7
BP 3515
EP 3529
DI 10.1128/JVI.02969-15
PG 15
WC Virology
SC Virology
GA DK7QQ
UT WOS:000375121200021
PM 26792737
ER
PT J
AU Eller, MA
Goonetilleke, N
Tassaneetrithep, B
Eller, LA
Costanzo, MC
Johnson, S
Betts, MR
Krebs, SJ
Slike, BM
Nitayaphan, S
Rono, K
Tovanabutra, S
Maganga, L
Kibuuka, H
Jagodzinski, L
Peel, S
Rolland, M
Marovich, MA
Kim, JH
Michael, NL
Robb, ML
Streeck, H
AF Eller, Michael A.
Goonetilleke, Nilu
Tassaneetrithep, Boonrat
Eller, Leigh Anne
Costanzo, Margaret C.
Johnson, Susan
Betts, Michael R.
Krebs, Shelly J.
Slike, Bonnie M.
Nitayaphan, Sorachai
Rono, Kathleen
Tovanabutra, Sodsai
Maganga, Lucas
Kibuuka, Hannah
Jagodzinski, Linda
Peel, Sheila
Rolland, Morgane
Marovich, Mary A.
Kim, Jerome H.
Michael, Nelson L.
Robb, Merlin L.
Streeck, Hendrik
TI Expansion of Inefficient HIV-Specific CD8 T Cells during Acute Infection
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID HUMAN-IMMUNODEFICIENCY-VIRUS; CHRONIC VIRAL-INFECTION; ANTIRETROVIRAL
THERAPY; TYPE-1 INFECTION; DISEASE PROGRESSION; CD27 EXPRESSION; SIV
INFECTION; HEPATITIS-B; RESPONSES; VIREMIA
AB Attrition within the CD4(+) T cell compartment, high viremia, and a cytokine storm characterize the early days after HIV infection. When the first emerging HIV-specific CD8(+) T cell responses gain control over viral replication it is incomplete, and clearance of HIV infection is not achieved even in the rare cases of individuals who spontaneously control viral replication to nearly immeasurably low levels. Thus, despite their partial ability to control viremia, HIV-specific CD8(+) T cell responses are insufficient to clear HIV infection. Studying individuals in the first few days of acute HIV infection, we detected the emergence of a unique population of CD38(+) CD27- CD8(+) T cells characterized by the low expression of the CD8 receptor (CD8(dim)). Interestingly, while high frequencies of HIV-specific CD8(+) T cell responses occur within the CD38(+) CD27(-) CD8(dim) T cell population, the minority populations of CD8(bright) T cells are significantly more effective in inhibiting HIV replication. Furthermore, the frequency of CD8(dim) T cells directly correlates with viral load and clinical predictors of more rapid disease progression. We found that a canonical burst of proliferative cytokines coincides with the emergence of CD8(dim) T cells, and the size of this population inversely correlates with the acute loss of CD4(+) T cells. These data indicate, for the first time, that early CD4(+) T cell loss coincides with the expansion of a functionally impaired HIV-specific CD8(dim) T cell population less efficient in controlling HIV viremia.
IMPORTANCE
A distinct population of activated CD8(+) T cells appears during acute HIV infection with diminished capacity to inhibit HIV replication and is predictive of viral set point, offering the first immunologic evidence of CD8(+) T cell dysfunction during acute infection.
C1 [Eller, Michael A.; Eller, Leigh Anne; Costanzo, Margaret C.; Johnson, Susan; Krebs, Shelly J.; Slike, Bonnie M.; Tovanabutra, Sodsai; Jagodzinski, Linda; Peel, Sheila; Rolland, Morgane; Marovich, Mary A.; Kim, Jerome H.; Michael, Nelson L.; Robb, Merlin L.; Streeck, Hendrik] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
[Eller, Michael A.; Eller, Leigh Anne; Costanzo, Margaret C.; Johnson, Susan; Krebs, Shelly J.; Slike, Bonnie M.; Tovanabutra, Sodsai; Rolland, Morgane; Robb, Merlin L.; Streeck, Hendrik] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
[Goonetilleke, Nilu] Univ N Carolina, Dept Immunol & Microbiol, Chapel Hill, NC USA.
[Tassaneetrithep, Boonrat] Mahidol Univ, Siriraj Hosp, Fac Med, Off Res & Dev, Bangkok 10700, Thailand.
[Betts, Michael R.] Univ Penn, Dept Microbiol, Perelman Sch Med, Philadelphia, PA 19104 USA.
[Nitayaphan, Sorachai] USAMC AFRIMS, Dept Retrovirol, Bangkok, Thailand.
[Rono, Kathleen] Walter Reed Project Kenya, Kericho, Kenya.
[Maganga, Lucas] Walter Reed Program Tanzania, Mbeya, Tanzania.
[Kibuuka, Hannah] Makerere Univ, Walter Reed Project, Kampala, Uganda.
[Streeck, Hendrik] Univ Duisburg Essen, Univ Hosp Essen, Inst HIV Res, Essen, Germany.
[Kim, Jerome H.] Int Vaccine Inst, Seoul, South Korea.
[Marovich, Mary A.] NIAID, 9000 Rockville Pike, Bethesda, MD 20892 USA.
RP Streeck, H (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.; Streeck, H (reprint author), Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.; Streeck, H (reprint author), Univ Duisburg Essen, Univ Hosp Essen, Inst HIV Res, Essen, Germany.
EM Hendrik.streeck@uk-essen.de
FU Henry M. Jackson Foundation for the Advancement of Military Medicine,
Inc. [W81XWH-11-2-0174]; U.S. Department of Defense (DoD)
[W81XWH-11-2-0174]
FX This work was supported by a cooperative agreement (W81XWH-11-2-0174)
between the Henry M. Jackson Foundation for the Advancement of Military
Medicine, Inc., and the U.S. Department of Defense (DoD).
NR 38
TC 3
Z9 3
U1 1
U2 1
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0022-538X
EI 1098-5514
J9 J VIROL
JI J. Virol.
PD APR
PY 2016
VL 90
IS 8
BP 4005
EP 4016
DI 10.1128/JVI.02785-15
PG 12
WC Virology
SC Virology
GA DK7RQ
UT WOS:000375123800019
PM 26842474
ER
PT J
AU Zander, NE
Gillan, M
Sweetser, D
AF Zander, Nicole E.
Gillan, Margaret
Sweetser, Daniel
TI Recycled PET Nanofibers for Water Filtration Applications
SO MATERIALS
LA English
DT Article
DE electrospinning; nanofibers; recycled PET; water filtration;
antimicrobial
ID MEMBRANES; COMPOSITE; SCAFFOLDS; OSMOSIS
AB Water shortage is an immediate and serious threat to our world population. Inexpensive and scalable methods to clean freshwater and wastewater are in high demand. Nanofiber filtration membranes represent a next generation nonwoven filter media due to their unique properties. Polyethlyene terephthalate (PET) is often used in the packaging of water and other commonly used materials, leading to a large amount of plastic waste often with limited incentive for recycling (few value-added uses). Here, we present work in the generation of nanofiber liquid filtration membranes from PET plastic bottles and demonstrate their use in microfiltration. PET nanofiber membranes were formed via solution electrospinning with fiber diameters as low as ca. 100 nm. Filtration efficiency was tested with latex beads with sizes ranging from 30 to 2000 nm. Greater than 99% of the beads as small as 500 nm were removed using gravity filtration. To reduce biofouling, the mats were functionalized with quaternary ammonium and biguanide biocides. The biguanide functionalized mats achieved 6 log reduction for both gram negative and gram positive bacteria.
C1 [Zander, Nicole E.; Gillan, Margaret; Sweetser, Daniel] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, Aberdeen, MD 21005 USA.
RP Zander, NE (reprint author), US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, Aberdeen, MD 21005 USA.
EM nicole.e.zander.civ@mail.mil; margaret.gillan2.ctr@mail.mil;
sweetser@udel.edu
NR 26
TC 1
Z9 1
U1 22
U2 44
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 1996-1944
J9 MATERIALS
JI Materials
PD APR
PY 2016
VL 9
IS 4
AR 247
DI 10.3390/ma9040247
PG 10
WC Materials Science, Multidisciplinary
SC Materials Science
GA DK8EB
UT WOS:000375158900033
ER
PT J
AU Treangen, TJ
Schoeler, G
Phillippy, AM
Bergman, NH
Turell, MJ
AF Treangen, Todd J.
Schoeler, George
Phillippy, Adam M.
Bergman, Nicholas H.
Turell, Michael J.
TI Identification and Genomic Analysis of a Novel Group C Orthobunyavirus
Isolated from a Mosquito Captured near Iquitos, Peru
SO PLOS NEGLECTED TROPICAL DISEASES
LA English
DT Article
ID AEDES-ALBOPICTUS; DIPTERA-CULICIDAE; UNITED-STATES; SINGLE-CELL; VIRUS;
SEQUENCES; ALIGNMENT; VALLEY; BUNYAVIRUSES; TRANSMISSION
AB Group C orthobunyaviruses are single-stranded RNA viruses found in both South and North America. Until very recently, and despite their status as important vector-borne human pathogens, no Group C whole genome sequences containing all three segments were available in public databases. Here we report a Group C orthobunyavirus, named El Huayo virus, isolated from a pool of Culex portesi mosquitoes captured near Iquitos, Peru. Although initial metagenomic analysis yielded only a handful of reads belonging to the genus Orthobunyavirus, single contig assemblies were generated for L, M, and S segments totaling over 200,000 reads (similar to 0.5% of sample). Given the moderately high viremia in hamsters (>10(7) plaque-forming units/ml) and the propensity for Cx. portesi to feed on rodents, it is possible that El Huayo virus is maintained in nature in a Culex portesi/rodent cycle. El Huayo virus was found to be most similar to Peruvian Caraparu virus isolates and constitutes a novel sub-clade within Group C.
C1 [Treangen, Todd J.; Phillippy, Adam M.; Bergman, Nicholas H.] Natl Biodef Anal & Countermeasures Ctr, Frederick, MD USA.
[Schoeler, George] US Naval Med Res Unit 6, Dept Entomol, Callao, Peru.
[Turell, Michael J.] US Army, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA.
[Schoeler, George] Bur Med & Surg, Falls Church, VA USA.
[Phillippy, Adam M.] NHGRI, Genome Informat Sect, Computat & Stat Genom Branch, NIH, Bethesda, MD 20892 USA.
RP Treangen, TJ (reprint author), Natl Biodef Anal & Countermeasures Ctr, Frederick, MD USA.
EM treangent@nbacc.net
FU Department of Homeland Security (DHS) Science and Technology Directorate
(ST) [HSHQDC-07-C-00020]; Federally Funded Research and Development
Center
FX This work was funded under Agreement No. HSHQDC-07-C-00020 awarded by
the Department of Homeland Security (DHS) Science and Technology
Directorate (S&T) for the management and operation of the National
Biodefense Analysis and Countermeasures Center (NBACC), a Federally
Funded Research and Development Center. The funders had no role in study
design, data collection and analysis, decision to publish, or
preparation of the manuscript.
NR 50
TC 0
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U1 0
U2 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1935-2735
J9 PLOS NEGLECT TROP D
JI Plos Neglect. Trop. Dis.
PD APR
PY 2016
VL 10
IS 4
AR e0004440
DI 10.1371/journal.pntd.0004440
PG 13
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA DL1FC
UT WOS:000375376700007
PM 27074162
ER
PT J
AU Blasch, K
Kolivosky, J
Hill, B
AF Blasch, Kyle
Kolivosky, John
Hill, Barry
TI Occupational exposures among personnel working near combined burn pit
and incinerator operations at Bagram Airfield, Afghanistan
SO INHALATION TOXICOLOGY
LA English
DT Article
DE Burn pit; incinerator; inhalation exposurePAHparticulate matter
ID RESPIRATORY SYMPTOMS; MILITARY PERSONNEL; DEPLOYED SETTINGS; HEALTH;
IRAQ; EMISSIONS; VETERANS; ILLNESS; INJURY; IMPACT
AB Occupational air samples were collected at Bagram Airfield Afghanistan for security forces (SF) stationed at the perimeter of the solid waste disposal facility that included a burn pit, air curtain destructors, and solid waste and medical waste incinerators. The objective of the investigation was to quantify inhalation exposures of workers near the disposal facility. Occupational air sample analytes included total particulates not otherwise specified (PNOS), respirable PNOS, acrolein and polyaromatic hydrocarbons (PAH). Exposures were measured for four SF job specialties. Thirty 12-hour shifts were monitored from November 2011 to March 2012. The geometric means for respirable particulate matter and PAH for all job specialties were below the 12-hour adjusted American Conference of Governmental Industrial Hygienists threshold limit value time weighted averages (TLV-TWA). The geometric mean of the respirable particulate matter 12-hour TWAs for the four job specialties ranged from 0.116 to 0.134 mg/m(3). One measurement collected at the tower (3.1 mg/m(3)) position exceeded the TLV-TWA. Naphthalene and pyrene were the only PAHs detected in multiple samples of the 18 PAHs analyzed. The geometric mean concentration for naphthalene was 9.39E-4 mg/m(3) and the maximum concentration was 0.0051 mg/m(3). The geometric mean of acrolein for the four job specialties ranged from 0.021 to 0.047 mg/m(3). There were four exceedances of the Occupational Safety and Health Administration 8-hour permissible exposure limit-time weighted average (PEL-TWA), respectively, ranging from 0.13 to 0.32 mg/m(3).
C1 [Blasch, Kyle] USAF, 230 Collins Rd, Boise, ID 83702 USA.
[Kolivosky, John] US Army, Inst Publ Hlth, Aberdeen Proving Ground, MD USA.
[Hill, Barry] US Air Force Sch Aerosp Med, Wright Patterson AFB, OH USA.
RP Blasch, K (reprint author), USAF, 230 Collins Rd, Boise, ID 83702 USA.
EM kblasch@usgs.gov
FU U.S. Department of Defense
FX Funding for this investigation was provided by the U.S. Department of
Defense.
NR 30
TC 1
Z9 1
U1 5
U2 6
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0895-8378
EI 1091-7691
J9 INHAL TOXICOL
JI Inhal. Toxicol.
PD APR
PY 2016
VL 28
IS 5
BP 216
EP 225
DI 10.3109/08958378.2016.1145768
PG 10
WC Toxicology
SC Toxicology
GA DK0VX
UT WOS:000374631400002
PM 27092584
ER
PT J
AU Herzig, MC
Cap, AP
AF Herzig, Maryanne C.
Cap, Andrew P.
TI Challenges in translating mesenchymal stem cell therapies for trauma and
critical care
SO TRANSFUSION
LA English
DT Editorial Material
ID DAMAGE CONTROL RESUSCITATION; STROMAL CELLS; CLINICAL-APPLICATIONS;
ADIPOSE-TISSUE; INJURY; ADULT; TUMORIGENICITY; MSC; REGENERATION;
TRANSFUSION
C1 [Herzig, Maryanne C.; Cap, Andrew P.] US Army, Coagulat & Blood Res Program, Inst Surg Res, JBSA Ft Sam Houston, San Antonio, TX USA.
RP Cap, AP (reprint author), US Army, Med Corps, Chicago, IL USA.; Cap, AP (reprint author), US Army, Blood Res, Inst Surg Res, Chicago, IL USA.; Cap, AP (reprint author), Uniformed Serv Univ Hlth Sci, Med, Bethesda, MD USA.; Cap, AP (reprint author), San Antonio Mil Med Ctr, 3650 Chambers Pass, Jbsa Ft Sam Houston, TX 78234 USA.
EM andrew.p.cap.mil@mail.mil
NR 75
TC 0
Z9 0
U1 1
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0041-1132
EI 1537-2995
J9 TRANSFUSION
JI Transfusion
PD APR
PY 2016
VL 56
IS 4
BP 20S
EP 25S
DI 10.1111/trf.13566
PG 6
WC Hematology
SC Hematology
GA DJ6ST
UT WOS:000374343900007
PM 27079318
ER
PT J
AU Dye, JM
Warfield, KL
Wells, JB
Unfer, RC
Shulenin, S
Vu, H
Nichols, DK
Aman, MJ
Bavari, S
AF Dye, John M.
Warfield, Kelly L.
Wells, Jay B.
Unfer, Robert C.
Shulenin, Sergey
Vu, Hong
Nichols, Donald K.
Aman, M. Javad
Bavari, Sina
TI Virus-Like Particle Vaccination Protects Nonhuman Primates from Lethal
Aerosol Exposure with Marburgvirus (VLP Vaccination Protects Macaques
against Aerosol Challenges)
SO VIRUSES-BASEL
LA English
DT Article
DE Marburg virus; virus-like particle; vaccine; macaque; aerosol; adjuvant
ID EBOLA-VIRUS; GUINEA-PIGS; HEMORRHAGIC-FEVER; INFECTION; VACCINES;
OUTBREAK; IMMUNOGENICITY; NUCLEOPROTEIN; GLYCOPROTEIN; IMMUNIZATION
AB Marburg virus (MARV) was the first filovirus to be identified following an outbreak of viral hemorrhagic fever disease in Marburg, Germany in 1967. Due to several factors inherent to filoviruses, they are considered a potential bioweapon that could be disseminated via an aerosol route. Previous studies demonstrated that MARV virus-like particles (VLPs) containing the glycoprotein (GP), matrix protein VP40 and nucleoprotein (NP) generated using a baculovirus/insect cell expression system could protect macaques from subcutaneous (SQ) challenge with multiple species of marburgviruses. In the current study, the protective efficacy of the MARV VLPs in conjunction with two different adjuvants: QS-21, a saponin derivative, and poly I:C against homologous aerosol challenge was assessed in cynomolgus macaques. Antibody responses against the GP antigen were equivalent in all groups receiving MARV VLPs irrespective of the adjuvant; adjuvant only-vaccinated macaques did not demonstrate appreciable antibody responses. All macaques were subsequently challenged with lethal doses of MARV via aerosol or SQ as a positive control. All MARV VLP-vaccinated macaques survived either aerosol or SQ challenge while animals administered adjuvant only exhibited clinical signs and lesions consistent withMARV disease and were euthanized after meeting the predetermined criteria. Therefore, MARV VLPs induce IgG antibodies recognizing MARV GP and VP40 and protect cynomolgus macaques from an otherwise lethal aerosol exposure with MARV.
C1 [Dye, John M.; Wells, Jay B.; Nichols, Donald K.; Bavari, Sina] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
[Warfield, Kelly L.; Unfer, Robert C.; Shulenin, Sergey; Vu, Hong; Aman, M. Javad] Integrated Biotherapeut Inc, Gaithersburg, MD 20878 USA.
RP Dye, JM (reprint author), US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.; Warfield, KL (reprint author), Integrated Biotherapeut Inc, Gaithersburg, MD 20878 USA.
EM john.m.dye1.civ@mail.mil; warfieldk@ebsi.com; jay.b.wells.ctr@mail.mil;
Robert.unfer@nih.gov; sergey@integratedbiotherapeutics.com;
hong@integratedbiotherapeutics.com; donald.k.nichols.civ@mail.mil;
javad@integratedbiotherapeutics.com; sina.bavari.civ@mail.mil
FU Defense Threat Reduction Agency JSTO-CBD
FX The research described herein was sponsored by the Defense Threat
Reduction Agency JSTO-CBD. The authors thank Sean VanTongeren, Kelly
Stuthman, Dave Dyer, Kathy Kuehl, Atefeh Rezaie, Clare Davis, and Shawn
Conley for excellent technical assistance, Erica Ollman Saphire and
Marnie Fusco for provision of the GP expression construct, Daniel Levey,
Charlotte Kensil, and Steve Monks of Agneus, Inc. for provision of QS-21
adjuvant and A. Salazar of Oncovir for provision of polyI:C adjuvant.
Opinions, conclusions, interpretations, and recommendations are those of
the authors and are not necessarily endorsed by the U.S. Army. The
mention of trade names or commercial products does not constitute
endorsement or recommendation for use by the Department of the Army or
the Department of Defense.
NR 53
TC 0
Z9 0
U1 2
U2 4
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 1999-4915
J9 VIRUSES-BASEL
JI Viruses-Basel
PD APR
PY 2016
VL 8
IS 4
AR 94
DI 10.3390/v8040094
PG 15
WC Virology
SC Virology
GA DK8DQ
UT WOS:000375157800008
PM 27070636
ER
PT J
AU Ewers, EC
Pratt, WD
Twenhafel, NA
Shamblin, J
Donnelly, G
Esham, H
Wlazlowski, C
Johnson, JC
Botto, M
Hensley, LE
Goff, AJ
AF Ewers, Evan C.
Pratt, William D.
Twenhafel, Nancy A.
Shamblin, Joshua
Donnelly, Ginger
Esham, Heather
Wlazlowski, Carly
Johnson, Joshua C.
Botto, Miriam
Hensley, Lisa E.
Goff, Arthur J.
TI Natural History of Aerosol Exposure with Marburg Virus in Rhesus
Macaques
SO VIRUSES-BASEL
LA English
DT Article
DE filovirus; nonhuman primate; Marburg virus; aerosol; telemetry; animal
model
ID EBOLA HEMORRHAGIC-FEVER; CYNOMOLGUS MACAQUES; INFECTED PATIENTS; ANGOLA
INFECTION; ZAIRE-EBOLAVIRUS; DISEASE; PATHOGENESIS; APOPTOSIS;
COAGULATION; RESPONSES
AB Marburg virus causes severe and often lethal viral disease in humans, and there are currently no Food and Drug Administration (FDA) approved medical countermeasures. The sporadic occurrence of Marburg outbreaks does not allow for evaluation of countermeasures in humans, so therapeutic and vaccine candidates can only be approved through the FDA animal rule-a mechanism requiring well-characterized animal models in which efficacy would be evaluated. Here, we describe a natural history study where rhesus macaques were surgically implanted with telemetry devices and central venous catheters prior to aerosol exposure with Marburg-Angola virus, enabling continuous physiologic monitoring and blood sampling without anesthesia. After a three to four day incubation period, all animals developed fever, viremia, and lymphopenia before developing tachycardia, tachypnea, elevated liver enzymes, decreased liver function, azotemia, elevated D-dimer levels and elevated pro-inflammatory cytokines suggesting a systemic inflammatory response with organ failure. The final, terminal period began with the onset of sustained hypotension, dehydration progressed with signs of major organ hypoperfusion (hyperlactatemia, acute kidney injury, hypothermia), and ended with euthanasia or death. The most significant pathologic findings were marked infection of the respiratory lymphoid tissue with destruction of the tracheobronchial and mediastinal lymph nodes, and severe diffuse infection in the liver, and splenitis.
C1 [Ewers, Evan C.; Twenhafel, Nancy A.; Goff, Arthur J.] Tripler Army Med Ctr, Dept Med, Honolulu, HI 96859 USA.
[Pratt, William D.; Twenhafel, Nancy A.; Shamblin, Joshua; Donnelly, Ginger; Esham, Heather; Wlazlowski, Carly; Botto, Miriam; Goff, Arthur J.] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
[Johnson, Joshua C.; Hensley, Lisa E.] NIAID, Integrated Res Facil, NIH, Frederick, MD 21702 USA.
RP Pratt, WD (reprint author), US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
EM evan.c.ewers.mil@mail.mil; william.d.pratt4.ctr@mail.mil;
nancy.a.twenhafel.mil@mail.mil; joshua.d.shamblin1.civ@mail.mil;
ginger.c.donnelly.ctr@mail.mil; heather.l.esham.civ@mail.mil;
carly.b.wlazlowski.ctr@mail.mil; joshua.johnson@nih.gov;
miriam.a.botto.civ@mail.mil; lisa.hensley@nih.gov;
arthur.j.goff.civ@mail.mil
OI Johnson, Joshua/0000-0002-5677-3841; Ewers, Evan/0000-0002-1384-9973
FU Defense Threat Reduction Agency
FX Financial contributions for this work were provided by the Defense
Threat Reduction Agency. The authors acknowledge the contributions of
Shannan Hall-Ursone for implant and catheter surgery of the animals, and
David O'Brien and Wendy Giles for technical expertise with these
studies.
NR 40
TC 0
Z9 0
U1 2
U2 3
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 1999-4915
J9 VIRUSES-BASEL
JI Viruses-Basel
PD APR
PY 2016
VL 8
IS 4
AR 87
DI 10.3390/v8040087
PG 16
WC Virology
SC Virology
GA DK8DQ
UT WOS:000375157800001
PM 27043611
ER
PT J
AU Shurtleff, AC
Bloomfield, HA
Mort, S
Orr, SA
Audet, B
Whitaker, T
Richards, MJ
Bavari, S
AF Shurtleff, Amy C.
Bloomfield, Holly A.
Mort, Shannon
Orr, Steven A.
Audet, Brian
Whitaker, Thomas
Richards, Michelle J.
Bavari, Sina
TI Validation of the Filovirus Plaque Assay for Use in Preclinical Studies
SO VIRUSES-BASEL
LA English
DT Article
DE plaque assay; filovirus; Ebola; ebolavirus; Marburgvirus; Marburg virus;
Vero E6 cells; GLP compliant; validation; animal rule
ID EBOLA-VIRUS; NONHUMAN-PRIMATES; MARBURG-VIRUS; CYNOMOLGUS MACAQUES;
INFECTIONS; VARIANTS; CULTURE; GUINEA
AB A plaque assay for quantitating filoviruses in virus stocks, prepared viral challenge inocula and samples from research animals has recently been fully characterized and standardized for use across multiple institutions performing Biosafety Level 4 (BSL-4) studies. After standardization studies were completed, Good Laboratory Practices (GLP)-compliant plaque assay method validation studies to demonstrate suitability for reliable and reproducible measurement of the Marburg Virus Angola (MARV) variant and Ebola Virus Kikwit (EBOV) variant commenced at the United States Army Medical Research Institute of Infectious Diseases (USAMRIID). The validation parameters tested included accuracy, precision, linearity, robustness, stability of the virus stocks and system suitability. The MARV and EBOV assays were confirmed to be accurate to +/- 0.5 log(10) PFU/mL. Repeatability precision, intermediate precision and reproducibility precision were sufficient to return viral titers with a coefficient of variation (%CV) of <= 30%, deemed acceptable variation for a cell-based bioassay. Intraclass correlation statistical techniques for the evaluation of the assay's precision when the same plaques were quantitated by two analysts returned values passing the acceptance criteria, indicating high agreement between analysts. The assay was shown to be accurate and specific when run on Nonhuman Primates (NHP) serum and plasma samples diluted in plaque assay medium, with negligible matrix effects. Virus stocks demonstrated stability for freeze-thaw cycles typical of normal usage during assay retests. The results demonstrated that the EBOV and MARV plaque assays are accurate, precise and robust for filovirus titration in samples associated with the performance of GLP animal model studies.
C1 [Shurtleff, Amy C.; Bavari, Sina] US Army, Med Res Inst Infect Dis, Mol & Translat Sci Div, 1425 Porter St, Frederick, MD 21702 USA.
[Bloomfield, Holly A.] US Army, Med Res Inst Infect Dis, Ctr Aerobiol Studies, 1425 Porter St, Frederick, MD 21702 USA.
[Mort, Shannon; Orr, Steven A.] US Army, Med Res Inst Infect Dis, Nonclin Dev Div, 1425 Porter St, Frederick, MD 21702 USA.
[Audet, Brian; Whitaker, Thomas; Richards, Michelle J.] US Army, Med Res Inst Infect Dis, Cell Culture Lab, Div Virol, 1425 Porter St, Frederick, MD 21702 USA.
RP Shurtleff, AC (reprint author), US Army, Med Res Inst Infect Dis, Mol & Translat Sci Div, 1425 Porter St, Frederick, MD 21702 USA.
EM amy.c.shurtleff.ctr@mail.mil; holly.a.bloomfield.civ@mail.mil;
shannon.m.mort.ctr@mail.mil; sorr@southernresearch.org;
brian.e.audet.civ@mail.mil; thomas.j.whitaker26.ctr@mail.mil;
michelle.j.richards.civ@mail.mil; sina.bavari.civ@mail.mil
FU USAMRIID
FX The opinions, interpretations, conclusions and recommendations in the
manuscript are those of the authors and are not necessarily endorsed by
the U.S. Army. The authors would like to thank Stephanie Valdez,
Deepmala Yadav, Prashant Yadav, Joseph Burns, Kristine Farrar and
Lucinda Leaman of the USAMRIID Cell Culture Laboratory, as well as Susan
Newcomb and Maureen Baran for quality control of the data. The authors
would also like to thank Dennis Taylor for project management and
coordination support of this research, as well Donna Hering, Han Seung,
Susan Godfrey and Carolyn Mentzer of USAMRIID Quality Assurance and
Regulatory Compliance Office (QARCO) for their role in the quality
assurance on this GLP study. We would also like to thank Steven J. Kern,
Biostatistician, for guidance and ICC analyses, and John C. Trefry and
Anna N. Honko for their scientific input at the early stages of the
work. This work was supported by USAMRIID institutional funds for GLP
assay validation.
NR 29
TC 0
Z9 0
U1 1
U2 1
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 1999-4915
J9 VIRUSES-BASEL
JI Viruses-Basel
PD APR
PY 2016
VL 8
IS 4
AR 113
DI 10.3390/v8040113
PG 20
WC Virology
SC Virology
GA DK8DQ
UT WOS:000375157800025
PM 27110807
ER
PT J
AU Moody, ML
Palomino, N
Weyl, PSR
Coetzee, JA
Newman, RM
Harms, NE
Liu, X
Thum, RA
AF Moody, Michael L.
Palomino, Nayell
Weyl, Philip S. R.
Coetzee, Julie A.
Newman, Raymond M.
Harms, Nathan E.
Liu, Xing
Thum, Ryan A.
TI Unraveling the biogeographic origins of the Eurasian watermilfoil
(Myriophyllum spicatum) invasion in North America
SO AMERICAN JOURNAL OF BOTANY
LA English
DT Article
DE aquatic plant; biocontrol; Eurasian watermilfoil; hybrid; invasion
pathway; invasive plant; Myriophyllum sibiricum; Myriophyllum spicatum;
phylogeography
ID BIOLOGICAL-CONTROL; PHYLOGENETIC INFERENCE; MULTIPLE INTRODUCTIONS;
EUHRYCHIOPSIS-LECONTEI; MAXIMUM-LIKELIHOOD; PLANT INVASIONS; EXOTIC
PLANT; SOUTH-AFRICA; HYBRIDIZATION; HALORAGACEAE
AB PREMISE OF THE STUDY: Using phylogeographic analyses to determine the geographic origins of biological invaders is important for identifying environmental adaptations and genetic composition in their native range as well as biocontrol agents among indigenous herbivores. Eurasian watermilfoil (Myriophyllum spicatum) and its hybrid with northern watermilfoil (M. sibiricum) are found throughout the contiguous United States and southern Canada, forming one of the most economically costly aquatic plant invasions in North America, yet the geographic origin of the invasion remains unknown. The objectives of our study included determining the geographic origin of Eurasian watermilfoil in North America as well as the maternal lineage of the hybrids.
METHODS: DNA sequence data from a cpDNA intron and the nrDNA ITS region were compiled for accessions from 110 populations of Eurasian watermilfoil and hybrids from North America and the native range (including Europe, Asia, and Africa). Datasets were analyzed using statistical parsimony and Bayesian phylogenetics to assess the geographic origin of the invasion.
KEY RESULTS: The two Eurasian watermilfoil cpDNA haplotypes in North America are also found from China and Korea, but not elsewhere in the native range. These haplotypes did not overlap and were limited in native geographic range. The ovule parent for hybrids can come from either parental lineage, and multiple haplotypes from both parental species were found.
CONCLUSIONS: The geographic origin of this prolific aquatic plant invasion of North America is in Asia. This provides critical information to better understand the invasion pathway and inform management into the future.
C1 [Moody, Michael L.; Palomino, Nayell] Univ Texas El Paso, Dept Biol Sci, El Paso, TX 79968 USA.
[Weyl, Philip S. R.; Coetzee, Julie A.] Rhodes Univ, Dept Zool & Entomol, ZA-6140 Grahamstown, South Africa.
[Newman, Raymond M.] Univ Minnesota, Dept Fisheries Wildlife & Conservat Biol, St Paul, MN 55108 USA.
[Harms, Nathan E.] US Army, Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS USA.
[Liu, Xing] Wuhan Univ, Coll Life Sci, Lab Plant Systemat & Evolutionary Biol, Wuhan 430072, Hubei, Peoples R China.
[Thum, Ryan A.] Montana State Univ, Dept Plant Sci & Plant Pathol, Bozeman, MT 59717 USA.
RP Moody, ML (reprint author), Univ Texas El Paso, Dept Biol Sci, El Paso, TX 79968 USA.
EM mlmoody@utep.edu
OI Weyl, Philip/0000-0002-0121-7266
FU Working for Water Program of the Natural Resource Management Programmes
(Department of Environmental Affairs), South Africa; University of
Minnesota CFANS faculty development award; University of Texas at El
Paso URI and COURI programs; Aquatic Plant Control Research Program of
the U.S. Army Corps of Engineers
FX We thank S. Arshid, R. Capers, S. Compton, A. Gander, P. Grillas, I.
Gunn, B. Hellquist, L. Henderson, D. Impson, S. Jeong, C. Lambertini, R.
Mangan, R. Monge, S. Park, J. Parsons, T. Riis, R. Sforza, K. Steffen,
and X. Xu for providing plant specimens to make this study possible.
Assistance with molecular data was provided by C. Anderson, M. Jeffers,
S. Parks, J. Pashnick, A. Pyman, and D. Wcisel. We thank two anonymous
reviewers for comments that improved the manuscript. The Working for
Water Program of the Natural Resource Management Programmes (Department
of Environmental Affairs), South Africa; University of Minnesota CFANS
faculty development award; University of Texas at El Paso URI and COURI
programs; and the Aquatic Plant Control Research Program of the U.S.
Army Corps of Engineers are thanked for their financial support of this
project.
NR 54
TC 0
Z9 0
U1 16
U2 27
PU BOTANICAL SOC AMER INC
PI ST LOUIS
PA PO BOX 299, ST LOUIS, MO 63166-0299 USA
SN 0002-9122
EI 1537-2197
J9 AM J BOT
JI Am. J. Bot.
PD APR
PY 2016
VL 103
IS 4
BP 709
EP 718
DI 10.3732/ajb.1500476
PG 10
WC Plant Sciences
SC Plant Sciences
GA DJ3ZA
UT WOS:000374144000014
PM 27033316
ER
PT J
AU Nichols, RA
Niagro, FD
Borke, JL
Cuenin, MF
AF Nichols, Richard A., Jr.
Niagro, Frank D.
Borke, James L.
Cuenin, Michael F.
TI Mechanical Stretching of Mouse Calvarial Osteoblasts In Vitro Models
Changes in MMP-2 and MMP-9 Expression at the Bone-Implant Interface
SO JOURNAL OF ORAL IMPLANTOLOGY
LA English
DT Article
DE bone; osteoblast; cyclic mechanical stretch; RT-PCR; zymography;
metalloproteinase; MMP; TIMP
ID MATRIX METALLOPROTEINASES; COLLAGENASE; INVITRO; STRAIN; CELLS
AB Bone to mechanical loading elicits a biological response that has clinical significance for several areas in dental medicine, including orthodontic tooth movement, tempromandibular joint disease, and endosseous dental implant osseointegration. Human orthopedic studies of failed hip implant sites have identified increased mRNA expression of several collagen-degrading matrix metalloproteinases (MMPs), while in vitro experiments have shown increases in MMP secretion after exposure to inflammatory mediators. This investigation evaluates the effects of mechanical deformation on in vitro osteoblasts by assessing changes in MMP gene expression and enzyme activity. We seeded mouse neonatal calvarial osteoblasts onto flexible 6-well plates and subjected to continuous cyclic mechanical stretching. The expression and activity of mRNA for several MMPs (2, 3, 9, and 10) was assessed. When subjected to mechanical stress in culture, only mRNA specific for MMP-9 was significantly increased compared to nonstretched controls (P < .005). Measurement of MMP activity by gelatin zymography demonstrated that none of the MMPs showed increased activity with stretching; however, MMP-2 activity decreased. Our results suggest that in response to stretch, MMP-2 responds rapidly by inhibiting conversion of a MMP-2 to the active form, while a slower up-regulation of MMP-9 may play a role in the long-term remodeling of extracellular matrix in response to continuous mechanical loading. This study suggests that the regulation of metalloproteinases at both the mRNA and protein level are important in the response of bone to mechanical stress.
C1 [Nichols, Richard A., Jr.] US Army Periodont Residency Program, Dent Act, Ft Gordon, GA USA.
[Niagro, Frank D.] Dwight D Eisenhower Army Med Ctr, Clin Invest Div, Ft Gordon, GA USA.
[Borke, James L.] Western Univ Hlth Sci, Coll Dent Med, Pomona, CA USA.
[Cuenin, Michael F.] Carolina Ctr Restorat Dent, Mt Pleasant, SC USA.
RP Borke, JL (reprint author), Western Univ Hlth Sci, Coll Dent Med, Pomona, CA USA.
EM jborke@westernu.edu
NR 26
TC 0
Z9 0
U1 2
U2 4
PU ALLEN PRESS INC
PI LAWRENCE
PA 810 E 10TH ST, LAWRENCE, KS 66044 USA
SN 0160-6972
EI 1548-1336
J9 J ORAL IMPLANTOL
JI J. Oral Implant.
PD APR
PY 2016
VL 42
IS 2
BP 138
EP 144
DI 10.1563/aaid-joi-D-14-00199
PG 7
WC Dentistry, Oral Surgery & Medicine
SC Dentistry, Oral Surgery & Medicine
GA DJ4TZ
UT WOS:000374202200004
PM 25961753
ER
PT J
AU Connelly, BC
Steenbergen, EH
Smith, HE
Elhamri, S
Mitchel, WC
Mou, S
Metcalfe, GD
Brown, GJ
Wraback, M
AF Connelly, Blair C.
Steenbergen, Elizabeth H.
Smith, Howard E.
Elhamri, Said
Mitchel, William C.
Mou, Shin
Metcalfe, Grace D.
Brown, Gail J.
Wraback, Michael
TI Dependence of minority carrier lifetime of Be-doped InAs/InAsSb type-II
infrared superlattices on temperature and doping density
SO PHYSICA STATUS SOLIDI B-BASIC SOLID STATE PHYSICS
LA English
DT Article; Proceedings Paper
CT Compound Semiconductor Week (CSW) / 42nd International Symposium on
Compound Semiconductors (ISCS) / 27th International Conferences on
Indium Phos-phide and Related Materials (IPRM)
CY JUN 28-JUL 02, 2015
CL Santa Barbara, CA
DE beryllium doping; InAs; minority-carrier lifetime; time-resolved
photoluminescence; type-II superlattices
AB We investigate the minority carrier lifetime of Be-doped InAs/InAsSb type-II superlattices as a function of doping density and temperature using time-resolved photoluminescence (TRPL) to determine if switching the superlattice type from the typical n-type residual carrier concentration to p-type may improve device performance by improving the lifetime-mobility product. The introduction of the Be dopant to the superlattice reduces the carrier lifetime, first by a factor of approximate to 3 for doping densities near or below the n-type residual carrier concentration, then by an order of magnitude for samples doped well above the residual carrier concentration. Further, the higher-doped p-type samples demonstrate two distinct TRPL decay regimes and two peaks in the PL spectra, suggesting the formation of an additional acceptor-related recombination pathway leading to the observed shorter carrier lifetime.
C1 [Connelly, Blair C.; Metcalfe, Grace D.; Wraback, Michael] US Army, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA.
[Steenbergen, Elizabeth H.; Mitchel, William C.; Mou, Shin; Brown, Gail J.] US Air Force, Res Lab, Mat & Mfg Directorate, Wright Patterson AFB, OH 45433 USA.
[Smith, Howard E.] Univ Dayton, Res Inst, Dayton, OH 45469 USA.
[Elhamri, Said] Univ Dayton, Dept Phys, Dayton, OH 45469 USA.
RP Connelly, BC (reprint author), US Army, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA.
EM blair.connelly.civ@mail.mil; elizabeth.steenbergen.1@us.af.mil
NR 17
TC 0
Z9 0
U1 7
U2 15
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 0370-1972
EI 1521-3951
J9 PHYS STATUS SOLIDI B
JI Phys. Status Solidi B-Basic Solid State Phys.
PD APR
PY 2016
VL 253
IS 4
BP 630
EP 634
DI 10.1002/pssb.201552497
PG 5
WC Physics, Condensed Matter
SC Physics
GA DJ3YL
UT WOS:000374142500005
ER
PT J
AU Karabiyik, M
Ahmadivand, A
Sinha, R
Al-Amin, C
Vabbina, PK
Kaya, S
Rupper, G
Rudin, S
Shur, M
Pala, N
AF Karabiyik, Mustafa
Ahmadivand, Arash
Sinha, Raju
Al-Amin, Chowdhury
Vabbina, Phani Kiran
Kaya, Serkan
Rupper, Greg
Rudin, Sergey
Shur, Michael
Pala, Nezih
TI Plasmonic properties of asymmetric dual grating gate plasmonic crystals
SO PHYSICA STATUS SOLIDI B-BASIC SOLID STATE PHYSICS
LA English
DT Article; Proceedings Paper
CT Compound Semiconductor Week (CSW) / 42nd International Symposium on
Compound Semiconductors (ISCS) / 27th International Conferences on
Indium Phos-phide and Related Materials (IPRM)
CY JUN 28-JUL 02, 2015
CL Santa Barbara, CA
DE plasmonic crystals; THz oscillations; two-dimensional electron gas
ID ELECTRON-MOBILITY TRANSISTORS; FIELD-EFFECT TRANSISTOR; TERAHERTZ
RADIATION; FLUID; WAVES; MODES
AB We report on numerical study of dispersion properties and frequency dependent absorption characteristics of asymmetric dual grating gate terahertz (THz) plasmonic crystals. The study shows that the dispersion relations of plasmons in a two-dimensional electron gas (2DEG) capped with asymmetric dual grating gates have energy band gaps in the Brillion zones. Depending on the wave vector, the plasmons can have symmetrical, anti-symmetrical, and asymmetrical charge distributions that are different from the ones for uniform gratings case. Plasmons in the studied plasmonic crystal exhibit both tightly confined/weakly coupled behavior and propagating/strongly coupled behavior depending on the plasmonic modes. The responsivity of the plasmonic detector based on asymmetric dual grating gate does not monotonically decrease with the frequency, which is in contrast to the responsivity of uniform grating THz detectors. The cross-section of an asymmetric dual grating gate terahertz plasmonic device under THz illumination is represented, where excited plasmons are shown in red.
C1 [Karabiyik, Mustafa; Ahmadivand, Arash; Sinha, Raju; Al-Amin, Chowdhury; Vabbina, Phani Kiran; Kaya, Serkan; Pala, Nezih] Florida Int Univ, Dept Elect & Comp Engn, Miami, FL 33172 USA.
[Rupper, Greg; Rudin, Sergey] US Army Res Lab, Adelphi, MD 20783 USA.
[Shur, Michael] Rensselaer Polytech Inst, Troy, NY 12180 USA.
RP Karabiyik, M (reprint author), Florida Int Univ, Dept Elect & Comp Engn, Miami, FL 33172 USA.
EM mustafakarabiyik@gmail.com
FU Army Research Laboratory (ARL) Multiscale Multidisciplinary Modeling of
Electronic Materials (MSME) Collaborative Research Alliance (CRA)
[W911NF-12-2-0023]; Army Research Office [W911NF-12-1-0071]
FX This work is supported by Army Research Laboratory (ARL) Multiscale
Multidisciplinary Modeling of Electronic Materials (MSME) Collaborative
Research Alliance (CRA) (Grant No. W911NF-12-2-0023) and Army Research
Office (Grant No. W911NF-12-1-0071).
NR 18
TC 0
Z9 0
U1 2
U2 3
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 0370-1972
EI 1521-3951
J9 PHYS STATUS SOLIDI B
JI Phys. Status Solidi B-Basic Solid State Phys.
PD APR
PY 2016
VL 253
IS 4
BP 671
EP 675
DI 10.1002/pssb.201552609
PG 5
WC Physics, Condensed Matter
SC Physics
GA DJ3YL
UT WOS:000374142500013
ER
PT J
AU Delaney, HM
Lucero, PF
Maves, RC
Lawler, JV
Maddry, JK
Biever, KA
Womble, SG
Coffman, RV
Murray, CK
AF Delaney, Heather M.
Lucero, Pedro F.
Maves, Ryan C.
Lawler, James V.
Maddry, Joseph K.
Biever, Kimberlie A.
Womble, Shannon G.
Coffman, Robert V.
Murray, Clinton K.
TI Ebola Virus Disease Simulation Case Series Patient With Ebola Virus
Disease in the Prodromal Phase of Illness (Scenario 1), the "Wet"
Gastrointestinal Phase of Illness (Scenario 2), and the Late, Critically
Ill Phase of Disease (Scenario 3)
SO SIMULATION IN HEALTHCARE-JOURNAL OF THE SOCIETY FOR SIMULATION IN
HEALTHCARE
LA English
DT Article
DE Ebola virus disease; Highly infectious diseases; Disaster preparedness;
Simulation; Crisis team training
ID AFRICA
AB Introduction: As part of an international response to the Ebola virus disease (EVD) outbreak, the US Department of Defense has deployed thousands of personnel to help train and augment international health care workers. The transmission risk of this deadly virus to health care workers has been extreme, demonstrating the importance of safe practices while caring for these patients. Medical simulation training is well recognized as an integral component for disease outbreak preparedness. Therefore, the US Government created a program of instruction that outlines a formalized EVD training program, using high-fidelity simulation, which projects both an understanding of the disease and its transmission risks.
Methods: Two 5-day training courses were established to provide training to the 65-member Department of Defense Ebola Response Team, which would be activated during a stateside Ebola outbreak. This training consisted of Ebola-specific protocols, personal protective equipment familiarization, and scenario-based certification for physicians, nurses, and public health trainers. Simulation was used to replicate the work environment inside an Ebola treatment unit.
Results: Three comprehensive clinical scenarios covering a wide spectrum of EVD presentations were designed around details of published cases to provide the most realistic and relevant EVD training available. The authors conducted 10 iterations of the 3 EVD clinical scenarios totaling more than 1100 hours of simulation training.
Conclusions: Quality practical exercises to include specialized task performance and collective teamwork training relied heavily on dedicated facilities and realistic medical simulation resulting in valuable lessons learned. In future iterations, these characteristics would be imperative to a successful training course.
C1 [Delaney, Heather M.; Lucero, Pedro F.; Maves, Ryan C.; Lawler, James V.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Delaney, Heather M.; Lucero, Pedro F.; Maddry, Joseph K.; Biever, Kimberlie A.; Womble, Shannon G.; Coffman, Robert V.; Murray, Clinton K.] Brooke Army Med Ctr, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
[Maves, Ryan C.] Naval Med Ctr San Diego, San Diego, CA USA.
[Lawler, James V.] Naval Med Res Ctr, Dept Clin Res, Frederick, MD USA.
RP Delaney, HM (reprint author), Brooke Army Med Ctr, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM heather.m.delaney.mil@mail.mil
FU Brooke Army Medical Center Command; Army North
FX The authors would like to sincerely thank all members of the Brooke Army
Medical Center Simulation Team for working tirelessly to carry out these
simulations. Also, they would like to thank key members of the critical
care nursing leadership for their support during this training. They
would like to thank Army North and the Brooke Army Medical Center
Command for their support and expertise during this training.
NR 15
TC 0
Z9 0
U1 2
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1559-2332
EI 1559-713X
J9 SIMUL HEALTHC
JI Simul. Healthc.
PD APR
PY 2016
VL 11
IS 2
BP 106
EP 116
DI 10.1097/SIH.0000000000000115
PG 11
WC Health Care Sciences & Services
SC Health Care Sciences & Services
GA DJ5VG
UT WOS:000374277600008
PM 27043096
ER
PT J
AU DeGregorio, BA
Weatherhead, PJ
Ward, MP
Sperry, JH
AF DeGregorio, Brett A.
Weatherhead, Patrick J.
Ward, Michael P.
Sperry, Jinelle H.
TI Do seasonal patterns of rat snake (Pantherophis obsoletus) and black
racer (Coluber constrictor) activity predict avian nest predation?
SO ECOLOGY AND EVOLUTION
LA English
DT Article
DE Activity patterns; automated radiotelemetry; nest cameras; nest
survival; northern cardinal; predator-prey
ID SONGBIRD NESTS; FOREST FRAGMENTATION; GRASSLAND BIRDS; HOME RANGES; OLD
FIELDS; HABITAT; MOVEMENTS; SURVIVAL; THERMOREGULATION; LANDSCAPE
AB Avian nest success often varies seasonally and because predation is the primary cause of nest failure, seasonal variation in predator activity has been hypothesized to explain seasonal variation in nest success. Despite the fact that nest predator communities are often diverse, recent evidence from studies of snakes that are nest predators has lent some support to the link between snake activity and nest predation. However, the strength of the relationship has varied among studies. Explaining this variation is difficult, because none of these studies directly identified nest predators, the link between predator activity and nest survival was inferred. To address this knowledge gap, we examined seasonal variation in daily survival rates of 463 bird nests (of 17 bird species) and used cameras to document predator identity at 137 nests. We simultaneously quantified seasonal activity patterns of two local snake species (N=30 individuals) using manual (2136 snake locations) and automated (89,165 movements detected) radiotelemetry. Rat snakes (Pantherophis obsoletus), the dominant snake predator at the site (similar to 28% of observed nest predations), were most active in late May and early June, a pattern reported elsewhere for this species. When analyzing all monitored nests, we found no link between nest predation and seasonal activity of rat snakes. When analyzing only nests with known predator identities (filmed nests), however, we found that rat snakes were more likely to prey on nests during periods when they were moving the greatest distances. Similarly, analyses of all monitored nests indicated that nest survival was not linked to racer activity patterns, but racer-specific predation (N=17 nests) of filmed nests was higher when racers were moving the greatest distances. Our results suggest that the activity of predators may be associated with higher predation rates by those predators, but that those effects can be difficult to detect when nest predator communities are diverse and predator identities are not known. Additionally, our results suggest that hand-tracking of snakes provides a reliable indicator of predator activity that may be more indicative of foraging behavior than movement frequency provided by automated telemetry systems.
C1 [DeGregorio, Brett A.; Weatherhead, Patrick J.; Ward, Michael P.; Sperry, Jinelle H.] Univ Illinois, Dept Nat Resources & Environm Sci, 1102 S Goodwin Ave, Champaign, IL 61801 USA.
[DeGregorio, Brett A.; Sperry, Jinelle H.] Engn Res & Dev Ctr, Champaign, IL USA.
RP DeGregorio, BA (reprint author), Univ Illinois, Dept Nat Resources & Environm Sci, 1102 S Goodwin Ave, Champaign, IL 61801 USA.
EM badegregorio@gmail.com
FU ERDC-CERL
FX Funding was provided by ERDC-CERL and was arranged by Tim Hayden.
NR 44
TC 0
Z9 0
U1 8
U2 16
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2045-7758
J9 ECOL EVOL
JI Ecol. Evol.
PD APR
PY 2016
VL 6
IS 7
BP 2034
EP 2043
DI 10.1002/ece3.1992
PG 10
WC Ecology; Evolutionary Biology
SC Environmental Sciences & Ecology; Evolutionary Biology
GA DJ2RE
UT WOS:000374052000012
PM 27099708
ER
PT J
AU Green, R
Lelis, A
Habersat, D
AF Green, Ron
Lelis, Aivars
Habersat, Daniel
TI Threshold-voltage bias-temperature instability in commercially-available
SiC MOSFETs
SO JAPANESE JOURNAL OF APPLIED PHYSICS
LA English
DT Article; Proceedings Paper
CT International Conference on Solid State Devices and Materials (SSDM)
CY SEP 27-30, 2015
CL Sapporo, JAPAN
SP Japan Soc Appl Phys
ID RELIABILITY; MECHANISMS; STABILITY; DEVICES; DMOSFET
AB This work reports on three important aspects of threshold-voltage instability in SiC power MOSFETs: (1) the threshold-voltage bias-temperature instability observed in commercial devices from two leading manufacturers, (2) a summary of the basic mechanisms driving this instability, and (3) the need for an improved test method for evaluating these devices. Even under significant overstress conditions, no negative threshold-voltage shift was observed in the most-recent-vintage commercial devices from one of the manufacturers during a -15V, 175 degrees C negative-bias temperature stress lasting 120 h. (C) 2016 The Japan Society of Applied Physics
C1 [Green, Ron; Lelis, Aivars; Habersat, Daniel] US Army Res Lab, Adelphi, MD 20783 USA.
RP Lelis, A (reprint author), US Army Res Lab, Adelphi, MD 20783 USA.
EM aivars.j.lelis.civ@mail.mil
NR 35
TC 1
Z9 1
U1 3
U2 5
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0021-4922
EI 1347-4065
J9 JPN J APPL PHYS
JI Jpn. J. Appl. Phys.
PD APR
PY 2016
VL 55
IS 4
SI SI
AR 04EA03
DI 10.7567/JJAP.55.04EA03
PG 7
WC Physics, Applied
SC Physics
GA DJ0YD
UT WOS:000373929400004
ER
PT J
AU Starks, TA
Miller, ML
Long, JM
AF Starks, T. A.
Miller, M. L.
Long, J. M.
TI Early life history of three pelagic-spawning minnows Macrhybopsis spp.
in the lower Missouri River
SO JOURNAL OF FISH BIOLOGY
LA English
DT Article
DE broadcast spawners; daily age; daily growth; diet; hatch date; otolith
ID LOWER YELLOWSTONE RIVERS; SICKLEFIN CHUB; GRAPHICAL ANALYSIS; FEEDING
STRATEGY; PALLID STURGEON; BRAIN PATTERNS; FISHES; HABITAT;
FRAGMENTATION; OTOLITHS
AB Life-history characteristics of age-0 sturgeon chub Macrhybopsis gelida, shoal chub Macrhybopsis hyostoma and sicklefin chub Macrhybopsis meeki were compared using several methods. All Macrhybopsis species consumed mostly midge pupae, but M. meeki had the most general diet (Levins' index, B = 022) compared with M. hyostoma (B = 002) and M. gelida (B = 009). Morisita's diet overlap index among species pairs ranged from 062 to 097 and was highest between M. hyostoma and M. gelida. Daily ages estimated from lapilli otoliths for each species ranged from 15 to 43 days for M. gelida, 19 to 44 for M. hyostoma and from 16 to 64 days for M. meeki. Mean growth rates ranged from 079 mm day(-1) for M. meeki to 139 mm day(-1) for M. gelida. Mortality estimates indicated high daily survivorship rates for M. meeki (0985), but could not be estimated for the other two species. Hatch date histograms were congruent with the belief that M. hyostoma and M. gelida spawn periodically from June to September. Macrhybopsis meeki, however, appeared to respond to a specific spawning cue as hatch dates were unimodal with a peak in July. These results fill a gap in current knowledge of these imperilled species that can be used to guide management decisions. (C) 2016 The Fisheries Society of the British Isles
C1 [Starks, T. A.] Oklahoma State Univ, Dept Nat Resources Ecol & Management, 008 Agr Hall, Stillwater, OK 74078 USA.
[Miller, M. L.] US Army, Corps Engineers, Habitat & Assessment Monitoring Program, 601 E 12th St, Kansas City, MO 64106 USA.
[Long, J. M.] Oklahoma State Univ, US Geol Survey, Dept Nat Resources Ecol & Management, Oklahoma Cooperat Fish & Wildlife Res Unit, 007 Agr Hall, Stillwater, OK 74078 USA.
RP Starks, TA (reprint author), Oklahoma State Univ, Dept Nat Resources Ecol & Management, 008 Agr Hall, Stillwater, OK 74078 USA.
EM tstarks1990@gmail.com
FU U.S. Army Corps of Engineers; U.S. Geological Survey [G12AC20430];
Oklahoma State University; Oklahoma Department of Wildlife Conservation;
U.S. Geological Survey; U.S. Fish and Wildlife Service; Wildlife
Management Institute
FX Financial support for this publication was provided by the U.S. Army
Corps of Engineers and the U.S. Geological Survey through Cooperative
Agreement G12AC20430. This study was performed under the auspices of a
protocol approved by the U.S. Army Corps of Engineers. T. Grabowski
provided constructive comments that improved the paper. The Oklahoma
Cooperative Fish and Wildlife Research Unit is supported by Oklahoma
State University, Oklahoma Department of Wildlife Conservation, U.S.
Geological Survey, U.S. Fish and Wildlife Service and Wildlife
Management Institute. Any use of trade, firm, or product names is for
descriptive purposes only and does not imply endorsement by the U.S.
Government.
NR 51
TC 0
Z9 0
U1 7
U2 14
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-1112
EI 1095-8649
J9 J FISH BIOL
JI J. Fish Biol.
PD APR
PY 2016
VL 88
IS 4
BP 1335
EP 1349
DI 10.1111/jfb.12892
PG 15
WC Fisheries; Marine & Freshwater Biology
SC Fisheries; Marine & Freshwater Biology
GA DJ2BO
UT WOS:000374008900004
PM 26887788
ER
PT J
AU Kiesling, EC
AF Kiesling, Eugenia C.
TI Deciphering Sun Tzu: How to Read the Art of War
SO JOURNAL OF MILITARY HISTORY
LA English
DT Book Review
C1 [Kiesling, Eugenia C.] US Mil Acad, West Point, NY 10996 USA.
RP Kiesling, EC (reprint author), US Mil Acad, West Point, NY 10996 USA.
NR 1
TC 0
Z9 0
U1 3
U2 3
PU SOC MILITARY HISTORY
PI LEXINGTON
PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA
24450-1600 USA
SN 0899-3718
EI 1543-7795
J9 J MILITARY HIST
JI J. Mil. Hist.
PD APR
PY 2016
VL 80
IS 2
BP 516
EP 517
PG 2
WC History
SC History
GA DI8KZ
UT WOS:000373751200010
ER
PT J
AU Kim, Y
Jo, H
Allen, JL
Choe, H
Wolfenstine, J
Sakamotok, J
AF Kim, Yunsung
Jo, Hyungyung
Allen, Jan L.
Choe, Heeman
Wolfenstine, Jeff
Sakamotok, Jeff
TI The Effect of Relative Density on the Mechanical Properties of
Hot-Pressed Cubic Li7La3Zr2O12
SO JOURNAL OF THE AMERICAN CERAMIC SOCIETY
LA English
DT Article
ID CRACK DEFLECTION PROCESSES; LI-ION CONDUCTORS; SOLID-ELECTROLYTE;
GRAIN-SIZE; FRACTURE-TOUGHNESS; AL; CONDUCTIVITY; CERAMICS; BATTERIES;
MICROSTRUCTURE
AB The effect of relative density on the hardness and fracture toughness of Al-substituted cubic garnet Li6.19Al0.27La3Zr2O12 (LLZO) was investigated. Polycrystalline LLZO was made using solid-state synthesis and hot-pressing. The relative density was controlled by varying the densification time at fixed temperature (1050 degrees C) and pressure (62 MPa). After hot-pressing, the average grain size varied from approximately 2.7-3.7 m for the 85% and 98% relative density samples, respectively. Examination of fracture surfaces revealed a transition from inter- to intragranular fracture as the relative density increased. The Vickers hardness increased with relative density up to 96%, above which the hardness was constant. At 98% relative density, the Vickers hardness was equal to the hardness measured by nanoindentation 9.1 GPa, which is estimated as the single-crystal hardness value. An inverse correlation between relative density and fracture toughness was observed. The fracture toughness increased linearly from 0.97 to 2.37 MPam for the 98% and 85% relative density samples, respectively. It is suggested that crack deflection along grain boundaries can explain the increase in fracture toughness with decreasing relative density. It was also observed that the total ionic conductivity increased from 0.0094 to 0.34 mS/cm for the 85%-98% relative density samples, respectively. The results of this study suggest that the microstructure of LLZO must be optimized to maximize mechanical integrity and ionic conductivity.
C1 [Kim, Yunsung] Michigan State Univ, Dept Chem Engn & Mat Sci, E Lansing, MI 48824 USA.
[Jo, Hyungyung; Choe, Heeman] Kookmin Univ, Dept Adv Mat Engn, Seoul 136702, South Korea.
[Allen, Jan L.; Wolfenstine, Jeff] RDRL SED C, Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
[Sakamotok, Jeff] Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA.
RP Kim, Y (reprint author), Michigan State Univ, Dept Chem Engn & Mat Sci, E Lansing, MI 48824 USA.
EM kimyuns1@msu.edu
RI Choe, Heeman/J-4053-2013
OI Choe, Heeman/0000-0002-5908-577X
FU Advanced Research Projects Agency-Energy [DE-AR0000399]; U.S. Army
Research Laboratory (ARL); DOE [DE-EE-00006821]; National Research
Foundation (NRF) of Korea [NRF-2014R1A2A1A11052513,
NRF-2012K1A3A1A12054894]
FX JS and YK acknowledge the support of Advanced Research Projects
Agency-Energy (DE-AR0000399); JW and JLA acknowledge the support of the
U.S. Army Research Laboratory (ARL). In addition, JW acknowledge the
support of DOE under contract DE-EE-00006821; HC also acknowledges the
support of the National Research Foundation (NRF) of Korea
(NRF-2014R1A2A1A11052513; NRF-2012K1A3A1A12054894).
NR 51
TC 3
Z9 3
U1 26
U2 62
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0002-7820
EI 1551-2916
J9 J AM CERAM SOC
JI J. Am. Ceram. Soc.
PD APR
PY 2016
VL 99
IS 4
BP 1367
EP 1374
DI 10.1111/jace.14084
PG 8
WC Materials Science, Ceramics
SC Materials Science
GA DJ0ZC
UT WOS:000373931900040
ER
PT J
AU Satapathy, S
Ahart, M
Dandekar, D
Hemley, RJ
Schuster, B
Khoma, P
AF Satapathy, Sikhanda
Ahart, Muhtar
Dandekar, Dattatraya
Hemley, Russell J.
Schuster, Brian
Khoma, Petro
TI Single-Crystal Elastic Properties of Aluminum Oxynitride (AlON) from
Brillouin Scattering
SO JOURNAL OF THE AMERICAN CERAMIC SOCIETY
LA English
DT Article
ID HIGH-PRESSURE; SPINEL; ALGORITHM; MODULI; CELL
AB The Brillouin light scattering technique was used to determine experimentally the three independent elastic constants of cubic aluminum oxynitride at the ambient condition. They are C11=334.8GPa,C12=164.4GPa, and C44=178.6+/- 1.1GPa. Its bulk modulus is 221.2 GPa. The magnitude of Zener anisotropic ratio is 2.1 similar to other spinels. The anisotropic nature of the material is shown by a large variation in the Young's modulus and Poisson's ratio with crystallographic directions. The material was found to be auxetic in certain orientations.
C1 [Satapathy, Sikhanda; Dandekar, Dattatraya; Schuster, Brian; Khoma, Petro] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Ahart, Muhtar; Hemley, Russell J.] Carnegie Inst Sci, Geophys Lab, 5251 Broad Branch Rd NW, Washington, DC 20015 USA.
RP Satapathy, S (reprint author), US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM sikhanda.s.satapathy.civ@mail.mil
FU EFree, an Energy Frontier Research Center - US Department of Energy,
Office of Science, Basic Energy Science [DE-SC-0001057]; US Department
of Energy/National Nuclear Security Administration [DE-NA-00006]
FX This research was partially supported by EFree, an Energy Frontier
Research Center funded by US Department of Energy, Office of Science,
Basic Energy Science under award DE-SC-0001057 (salary support for M.
A.) and the facilities used at Carnegie were supported by the US
Department of Energy/National Nuclear Security Administration
(DE-NA-00006, CDAC.)
NR 24
TC 0
Z9 0
U1 3
U2 13
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0002-7820
EI 1551-2916
J9 J AM CERAM SOC
JI J. Am. Ceram. Soc.
PD APR
PY 2016
VL 99
IS 4
BP 1383
EP 1389
DI 10.1111/jace.14065
PG 7
WC Materials Science, Ceramics
SC Materials Science
GA DJ0ZC
UT WOS:000373931900042
ER
PT J
AU Ensley, TR
Hu, HH
Reichert, M
Ferdinandus, MR
Peceli, D
Hales, JM
Perry, JW
Li, ZA
Jang, SH
Jen, AKY
Marder, SR
Hagan, DJ
Van Stryland, EW
AF Ensley, Trenton R.
Hu, Honghua
Reichert, Matthew
Ferdinandus, Manuel R.
Peceli, Davorin
Hales, Joel M.
Perry, Joseph W.
Li, Zhong'an
Jang, Sei-Hum
Jen, Alex K. -Y.
Marder, Seth R.
Hagan, David J.
Van Stryland, Eric W.
TI Quasi-three-level model applied to measured spectra of nonlinear
absorption and refraction in organic molecules
SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICS
LA English
DT Article
ID SIGNAL-PROCESSING APPLICATIONS; BOND-LENGTH ALTERNATION; OPTICAL-DATA
STORAGE; 2-PHOTON ABSORPTION; POLYMETHINE DYES; 1ST HYPERPOLARIZABILITY;
PERTURBATION THEORY; SOLID-STATE; CHROMOPHORES; DESIGN
AB Materials with a large nonlinear refractive index (n(2)) and relatively small linear and nonlinear absorption losses, namely, two-photon absorption (2PA, of coefficient alpha(2)), have long been sought after for applications such as alloptical switching (AOS). Here we experimentally determine the linear and 2PA properties of several organic molecules, which we approximate as centrosymmetric, and use a simplified essential-state model (quasi-three-level model) to predict the dispersion of n(2). We then compare these predictions with experimental measurements of n(2) and find good agreement. Here "quasi"-three-level means using a single one-photon allowed intermediate state and multiple (here two) two-photon allowed states. This also allows predictions of the figure-of-merit (FOM), defined as the ratio of nonlinear refractive phase shift to the 2PA fractional loss, that determines the viability for such molecules to be used in device applications. The model predicts that the optimized wavelength range for a large FOM lies near the short wavelength linear absorption edge for cyanine-like dyes where the magnitude of n2 is quite large. However, 2PA bands lying close to the linear absorption edge in certain classes of molecules can greatly reduce this FOM. We identify two molecules having a large FOM for AOS. We note that the FOM is often defined as the ratio of real to imaginary parts of the third-order susceptibility (chi((3))) with multiple processes leading to both components. As explained later in this paper, such definitions require care to only include the 2PA contribution to the imaginary part of chi((3)) in regions of transparency. (C) 2016 Optical Society of America
C1 [Ensley, Trenton R.; Hu, Honghua; Reichert, Matthew; Ferdinandus, Manuel R.; Peceli, Davorin; Hagan, David J.; Van Stryland, Eric W.] Univ Cent Florida, Coll Opt & Photon, CREOL, Orlando, FL 32816 USA.
[Ensley, Trenton R.] US Army Res Lab, Adelphi, MD 20783 USA.
[Ferdinandus, Manuel R.] Air Force Inst Technol, Dept Engn Phys, Dayton, OH 45433 USA.
[Hales, Joel M.; Perry, Joseph W.; Marder, Seth R.] Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA.
[Hales, Joel M.; Perry, Joseph W.; Marder, Seth R.] Georgia Inst Technol, Ctr Organ Photon & Elect, Atlanta, GA 30332 USA.
[Li, Zhong'an; Jang, Sei-Hum; Jen, Alex K. -Y.] Univ Washington, Dept Mat Sci & Engn, Seattle, WA 98195 USA.
[Hagan, David J.; Van Stryland, Eric W.] Univ Cent Florida, Dept Phys, Orlando, FL 32816 USA.
RP Van Stryland, EW (reprint author), Univ Cent Florida, Coll Opt & Photon, CREOL, Orlando, FL 32816 USA.; Van Stryland, EW (reprint author), Univ Cent Florida, Dept Phys, Orlando, FL 32816 USA.
EM ewvs@creol.ucf.edu
RI Hagan, David/H-2204-2011; Reichert, Matthew/N-1191-2015
OI Hagan, David/0000-0003-2713-1767; Reichert, Matthew/0000-0003-1701-9376
FU National Science Foundation (NSF) (ECS) [1202471, MRI 1229563]; Air
Force Office of Scientific Research (AFOSR) MURI [FA9550-10-1-0558]
FX National Science Foundation (NSF) (ECS#1202471, MRI 1229563); Air Force
Office of Scientific Research (AFOSR) MURI (FA9550-10-1-0558).
NR 59
TC 4
Z9 4
U1 7
U2 13
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 0740-3224
EI 1520-8540
J9 J OPT SOC AM B
JI J. Opt. Soc. Am. B-Opt. Phys.
PD APR 1
PY 2016
VL 33
IS 4
BP 780
EP 796
DI 10.1364/JOSAB.33.000780
PG 17
WC Optics
SC Optics
GA DJ3LH
UT WOS:000374106200037
ER
PT J
AU Villazanakretzer, DL
Napolitano, PG
Cummings, KF
Magann, EF
AF Villazanakretzer, Diana L.
Napolitano, Peter G.
Cummings, Kelly F.
Magann, Everett F.
TI Fish Parasites: A Growing Concern During Pregnancy
SO OBSTETRICAL & GYNECOLOGICAL SURVEY
LA English
DT Article
ID INFECTIONS; DISEASE; NEMATODA; TAPEWORM; SALMON; IMPACT
AB Intestinal parasitic worms affect more than 2 billion people worldwide according to the World Health Organization. Fish-borne parasitic infections are becoming more common with the increasing popularity of sushi, sashimi, Carpaccio, tartare, gefilte, and ceviche. The ingestion of these parasites can cause serve anemia, malabsorption, severe abdominal pain, nausea, vomiting, strong allergic reactions, and gastric ulcers. Knowledge about fish parasites and pregnancy is limited.
A literature search on PubMed and Web of Science used the search terms "fish parasites" OR "diphyllobothrium" OR "anisakiasis" OR "pseudoterranova" OR ("food borne parasites" AND "fish") AND "pregnancy" OR "maternal" OR "fetus" OR "fetal" OR "newborn" OR "neonatal" OR "childbirth." No limit was put on the number of years searched.
There were 281 publications identified. The abstracts of all of these publications were read. After exclusion of the articles that were not relevant to pregnancy, pregnancy outcome, and fish parasites, there were 24 articles that became the basis of this review. The pathophysiology, altered maternal immunity related to the infection, limited information about fish-borne parasitic infections and pregnancy, and treatments are discussed.
The main impact of a fish-borne parasitic infection on pregnant women is anemia and altered immunity, which may increase the risk of a maternal infection. The primary fetal effects include intrauterine growth restriction and preterm delivery.
Target Audience
Obstetricians and gynecologists, family physicians.
Learning Objectives
After completing this activity, the learner should be better able to recognize the global impact of intestinal parasitic worm infections; identify the 3 fish-borne parasites that affect humans; understand the immunologic response of a pregnant patient to an invading parasite; summarize the current treatment for the fish parasites.
C1 [Villazanakretzer, Diana L.; Napolitano, Peter G.] US Army Med Corps, Madigan Army Med Ctr, Dept Obstet, Joint Base Lewis McChord, WA USA.
[Villazanakretzer, Diana L.; Napolitano, Peter G.] US Army Med Corps, Madigan Army Med Ctr, Dept Gynecol, Joint Base Lewis McChord, WA USA.
[Cummings, Kelly F.; Magann, Everett F.] Univ Arkansas Med Sci, Little Rock, AR 72205 USA.
[Magann, Everett F.] Univ Arkansas Med Sci, MFM Div, Little Rock, AR 72205 USA.
RP Magann, EF (reprint author), Univ Arkansas Med Sci, Dept Obstet & Gynecol, 4301 W Markham St,Slot 518, Little Rock, AR 72205 USA.
EM efmagann@uams.edu
NR 22
TC 0
Z9 0
U1 3
U2 16
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0029-7828
EI 1533-9866
J9 OBSTET GYNECOL SURV
JI Obstet. Gynecol. Surv.
PD APR
PY 2016
VL 71
IS 4
BP 253
EP 259
DI 10.1097/OGX.0000000000000303
PG 7
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA DJ0XE
UT WOS:000373926900003
PM 27065071
ER
PT J
AU Capasso, R
Rosa, T
Tsou, DYA
Nekhendzy, V
Drover, D
Collins, J
Zaghi, S
Camacho, M
AF Capasso, Robson
Rosa, Talita
Tsou, David Yung-An
Nekhendzy, Vladimir
Drover, David
Collins, Jeremy
Zaghi, Soroush
Camacho, Macario
TI Variable Findings for Drug-Induced Sleep Endoscopy in Obstructive Sleep
Apnea with Propofol versus Dexmedetomidine
SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY
LA English
DT Article
DE propofol; dexmedetomidine; sleep endoscopy; obstructive sleep apnea;
VOTE classification
ID INDUCED SEDATION ENDOSCOPY; UPPER AIRWAY MORPHOLOGY; INCREASING DEPTH;
MULLER MANEUVER; ANESTHESIA; MIDAZOLAM; VOLUNTEERS; MANAGEMENT;
CHILDREN; EFFICACY
AB Objective To compare VOTE classification findings (velum, oropharyngeal-lateral walls, tongue base, and epiglottis) for drug-induced sleep endoscopy (DISE) among patients with obstructive sleep apnea (OSA) using 2 sedation protocols.
Study Design Case series with chart review.
Setting Single tertiary institution.
Subjects Patients with OSA who underwent DISE.
Methods A total of 216 patients underwent DISE between November 23, 2011, and May 1, 2015. DISE findings based on VOTE classification were compared between patients receiving the propofol- and dexmedetomidine-based sedation protocols.
Results Patients with OSA (N = 216; age, 44.3 11.7 years; body mass index, 27.9 +/- 4.8 kg/m(2)) underwent DISE with intravenous administration of propofol (n = 52) or dexmedetomidine (n = 164). There were no statistically significant differences between the 2 groups in baseline apnea-hypopnea index, oxygen desaturation index, Mallampati score, tonsil size, Epworth Sleepiness Scale score, peripheral oxygen saturation nadir, age, sex, or body mass index. Patients in the propofol group had a significantly increased likelihood of demonstrating complete tongue base obstruction (75%, 39 of 52) versus partial or no obstruction (25%, 13 of 52) in the anterior-posterior dimension, as compared with the dexmedetomidine group (complete obstruction: 42.7%, 70 of 164; partial or no obstruction: 57.3%, 94 of 164; odds ratio: 4.0; 95% confidence interval: 2.0-8.1; P = .0001). Obstruction of other airway subsites was not significantly different.
Conclusion Use of propofol versus dexmedetomidine to induce sedation may have a significant effect on the pattern of upper airway obstruction observed during DISE. Randomized prospective studies are indicated to confirm these initial findings.
C1 [Capasso, Robson; Rosa, Talita; Tsou, David Yung-An; Zaghi, Soroush] Stanford Univ, Dept Otolaryngol Head & Neck Surg, Div Sleep Surg, Stanford, CA 94305 USA.
[Tsou, David Yung-An] China Med Univ Hosp, Dept Otolaryngol, Taichung, Taiwan.
[Nekhendzy, Vladimir; Drover, David; Collins, Jeremy] Stanford Univ, Dept Anesthesiol, Stanford, CA 94305 USA.
[Camacho, Macario] Tripler Army Med Ctr, Div Sleep Surg & Med, Dept Otolaryngol, Oahu, HI USA.
[Camacho, Macario] Stanford Univ, Dept Otolaryngol, Div Sleep Med, Redwood City, CA USA.
RP Capasso, R (reprint author), Stanford Univ, Dept Otolaryngol Head & Neck Surg, Sch Med, 801 Welch Rd, Palo Alto, CA 94305 USA.
EM rcapasso@ohns.stanford.edu
NR 46
TC 5
Z9 5
U1 1
U2 20
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0194-5998
EI 1097-6817
J9 OTOLARYNG HEAD NECK
JI Otolaryngol. Head Neck Surg.
PD APR
PY 2016
VL 154
IS 4
BP 765
EP 770
DI 10.1177/0194599815625972
PG 6
WC Otorhinolaryngology; Surgery
SC Otorhinolaryngology; Surgery
GA DJ2FL
UT WOS:000374019100029
PM 26814208
ER
PT J
AU Shaw, AP
Brusnahan, JS
Poret, JC
Morris, LA
AF Shaw, Anthony P.
Brusnahan, Jason S.
Poret, Jay C.
Morris, Lauren A.
TI Thermodynamic Modeling of Pyrotechnic Smoke Compositions
SO ACS SUSTAINABLE CHEMISTRY & ENGINEERING
LA English
DT Article
DE Smoke; Obscurants; Pyrotechnics; Thermodynamics; Modeling
ID BORON PHOSPHIDE; PHOSPHORUS; MUNITIONS
AB Some of the most effective visible obscurants for military applications are toxic or incendiary or present serious logistical complications. Sustainable alternatives are needed to mitigate the risks of human exposure and environmental contamination. The FactSage 6.4 software package was used to model the thermodynamics of pyrotechnic smoke compositions based on boron carbide, hexachloroethane, and phosphorus. The computational results are shown to be relevant in light of prior experimental observations. Boron phosphide is proposed as a benign source of phosphorus for next-generation pyrotechnic smoke compositions. The thermodynamics of the BP-KNO3 system have been studied computationally. The results indicate that certain stoichiometries should produce elemental phosphorus upon combustion. The properties of the BP-KNO3 system are examined considering the functional requirements of smoke munitions.
C1 [Shaw, Anthony P.; Poret, Jay C.; Morris, Lauren A.] US Army RDECOM ARDEC, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07806 USA.
[Brusnahan, Jason S.] Def Sci & Technol Grp, Edinburgh, SA 5111, Australia.
RP Shaw, AP (reprint author), US Army RDECOM ARDEC, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07806 USA.
EM anthony.p.shaw.civ@mail.mil
FU U.S. Army
FX Zhaohua Luan, Christopher D. Haines, Rajendra K. Sadangi, and Jared D.
Moretti are thanked for useful discussions. The U.S. Army is thanked for
funding this work.
NR 46
TC 2
Z9 2
U1 5
U2 12
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 2168-0485
J9 ACS SUSTAIN CHEM ENG
JI ACS Sustain. Chem. Eng.
PD APR
PY 2016
VL 4
IS 4
BP 2309
EP 2315
DI 10.1021/acssuschemeng.5b01762
PG 7
WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY;
Engineering, Chemical
SC Chemistry; Science & Technology - Other Topics; Engineering
GA DI5QV
UT WOS:000373554600050
ER
PT J
AU Wampler, DA
Pineda, C
Polk, J
Kidd, E
Leboeuf, D
Flores, M
Shown, M
Kharod, C
Stewart, RM
Cooley, C
AF Wampler, David A.
Pineda, Chloe
Polk, Joan
Kidd, Emily
Leboeuf, Dale
Flores, Marti
Shown, Mike
Kharod, Chetan
Stewart, Ronald M.
Cooley, Craig
TI The long spine board does not reduce lateral motion during transport-a
randomized healthy volunteer crossover trial
SO AMERICAN JOURNAL OF EMERGENCY MEDICINE
LA English
DT Article
ID IMMOBILIZATION; INJURIES; PAIN
AB Objective: For thirty years, emergency medical services agencies have emphasized limiting spinal motion during transport of the trauma patient to the emergency department. The long spine board (LSB) has been the mainstay of spinal motion restriction practices, despite the paucity of data to support its use. The purpose of this study was to determine reduction in lateral motion afforded by the LSB in comparison to the stretcher mattress alone.
Methods: This was a randomized controlled crossover trial where healthy volunteer subjects were randomly assigned to either LSB or stretcher mattress only. All subjects were fitted with a rigid cervical collar, secured to the assigned device (including foam head blocks), and driven on a closed course with prescribed turns at a low speed (<20 mph). Upon completion, the subjects were then secured to the other device and the course was repeated. Each subject was fitted with 3 graduated-paper disks (head, chest, hip). Lasers were affixed to a scaffold attached to the stretcher bridging over the patient and aimed at the center of the concentric graduations on the disks. During transport, the degree of lateral movement was recorded during each turn. Significance was determined by t test.
Results: In both groups, the head demonstrated the least motion with 0.46 +/- 0.4-cm mattress and 0.97 +/- 0.7-cm LSB (P <= .0001). The chest and hip had lateral movement with chest 1.22 +/- 0.9-cm mattress and 2.22 +/- 1.4-cm LSB (P <= .0001), and the hip 1.20 +/- 0.9-cm mattress and 1.88 +/- 1.2-cm LSB (P <= .0001), respectively. In addition, lateral movement had a significant direct correlation with body mass index.
Conclusion: The stretcher mattress significantly reduced lateral movement during transport. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Wampler, David A.; Pineda, Chloe; Polk, Joan; Kidd, Emily; Stewart, Ronald M.; Cooley, Craig] Univ Texas Hlth Sci Ctr San Antonio, 4201 Med Dr,Suite 120, San Antonio, TX 78229 USA.
[Leboeuf, Dale] US Army, Houston, TX USA.
[Flores, Marti] San Antonio Fire Dept, San Antonio, TX USA.
[Shown, Mike] City Schertz Emergency Med Serv, Schertz, TX USA.
[Kharod, Chetan] Mil EMS & Disaster Med Fellowship, Houston, TX USA.
RP Wampler, DA (reprint author), Univ Texas Hlth Sci Ctr San Antonio, 4201 Med Dr,Suite 120, San Antonio, TX 78229 USA.
EM wamplerd@uthscsa.edu
OI Kharod, Chetan/0000-0003-4352-8887
FU San Antonio Fire Department; SAFD Office of the Medical Director;
University of Texas Health Science Center at San Antonio Department of
Emergency Health Sciences
FX This work was also supported, in part, by the San Antonio Fire
Department and the SAFD Office of the Medical Director, along with
University of Texas Health Science Center at San Antonio Department of
Emergency Health Sciences internal funding. The Southwest Texas Regional
Advisory Council's Research Committee also contributed intellectual
effort in the design of this protocol.
NR 16
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U1 3
U2 4
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0735-6757
EI 1532-8171
J9 AM J EMERG MED
JI Am. J. Emerg. Med.
PD APR
PY 2016
VL 34
IS 4
BP 717
EP 721
DI 10.1016/j.ajem.2015.12.078
PG 5
WC Emergency Medicine
SC Emergency Medicine
GA DI4TI
UT WOS:000373491800007
PM 26827233
ER
PT J
AU Sharp, NJ
Molineux, IJ
Page, MA
Schofield, DA
AF Sharp, Natasha J.
Molineux, Ian J.
Page, Martin A.
Schofield, David A.
TI Rapid Detection of Viable Bacillus anthracis Spores in Environmental
Samples by Using Engineered Reporter Phages
SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY
LA English
DT Article
ID DECONTAMINATION; BACTERIOPHAGE; SUBTILIS; SOIL; DNA; IDENTIFICATION;
POLYMERASE; INFECTION; PROMOTER; PCR
AB Bacillus anthracis, the causative agent of anthrax, was utilized as a bioterrorism agent in 2001 when spores were distributed via the U.S. postal system. In responding to this event, the Federal Bureau of Investigation used traditional bacterial culture viability assays to ascertain the extent of contamination of the postal facilities within 24 to 48 h of environmental sample acquisition. Here, we describe a low-complexity, second-generation reporter phage assay for the rapid detection of viable B. anthracis spores in environmental samples. The assay uses an engineered B. anthracis reporter phage (W beta::luxAB-2) which transduces bioluminescence to infected cells. To facilitate low-level environmental detection and maximize the signal response, expression of luxAB in an earlier version of the reporter phage (W beta::luxAB-1) was optimized. These alterations prolonged signal kinetics, increased light output, and improved assay sensitivity. Using W beta::luxAB-2, detection of B. anthracis spores was 1 CFU in 8 h from pure cultures and as low as 10 CFU/g in sterile soil but increased to 105 CFU/g in unprocessed soil due to an unstable signal and the presence of competing bacteria. Inclusion of semiselective medium, mediated by a phage-expressed antibiotic resistance gene, maintained signal stability and enabled the detection of 104 CFU/g in 6 h. The assay does not require spore extraction and relies on the phage infecting germinating cells directly in the soil sample. This reporter phage displays promise for the rapid detection of low levels of spores on clean surfaces and also in grossly contaminated environmental samples from complex matrices such as soils.
C1 [Sharp, Natasha J.; Schofield, David A.] Guild BioSci, Charleston, SC USA.
[Molineux, Ian J.] Univ Texas Austin, Inst Cellular & Mol Biol, Mol Biosci, Austin, TX 78712 USA.
[Page, Martin A.] US Army Corps Engineersn, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL USA.
RP Schofield, DA (reprint author), Guild BioSci, Charleston, SC USA.
EM dschofield@guildbiosciences.com
FU Defense Threat Reduction Agency [BA11PHM148]; United States Army
Engineer Research and Development Center [W9132T-12-C-0017]; HHS | NIH |
National Institute of Allergy and Infectious Diseases (NIAID)
[R01AI111535]
FX Defense Threat Reduction Agency provided funding to the United States
Army Engineer Research and Development Center under grant number
BA11PHM148. United States Army Engineer Research and Development Center
provided funding to David A. Schofield under grant number
W9132T-12-C-0017. HHS | NIH | National Institute of Allergy and
Infectious Diseases (NIAID) provided funding to David A. Schofield under
grant number R01AI111535.
NR 46
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Z9 0
U1 9
U2 14
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0099-2240
EI 1098-5336
J9 APPL ENVIRON MICROB
JI Appl. Environ. Microbiol.
PD APR
PY 2016
VL 82
IS 8
BP 2380
EP 2387
DI 10.1128/AEM.03772-15
PG 8
WC Biotechnology & Applied Microbiology; Microbiology
SC Biotechnology & Applied Microbiology; Microbiology
GA DI2RB
UT WOS:000373343300016
PM 26873316
ER
PT J
AU Quinn, CP
Sabourin, CL
Schiffer, JM
Niemuth, NA
Semenova, VA
Li, H
Rudge, TL
Brys, AM
Mittler, RS
Ibegbu, CC
Wrammert, J
Ahmed, R
Parker, SD
Babcock, J
Keitel, W
Poland, GA
Keyserling, HL
El Sahly, H
Jacobson, RM
Marano, N
Plikaytis, BD
Wright, JG
AF Quinn, Conrad P.
Sabourin, Carol L.
Schiffer, Jarad M.
Niemuth, Nancy A.
Semenova, Vera A.
Li, Han
Rudge, Thomas L.
Brys, April M.
Mittler, Robert S.
Ibegbu, Chris C.
Wrammert, Jens
Ahmed, Rafi
Parker, Scott D.
Babcock, Janiine
Keitel, Wendy
Poland, Gregory A.
Keyserling, Harry L.
El Sahly, Hana
Jacobson, Robert M.
Marano, Nina
Plikaytis, Brian D.
Wright, Jennifer G.
TI Humoral and Cell-Mediated Immune Responses to Alternate Booster
Schedules of Anthrax Vaccine Adsorbed in Humans
SO CLINICAL AND VACCINE IMMUNOLOGY
LA English
DT Article
ID LETHAL TOXIN NEUTRALIZATION; INHALATION ANTHRAX; PROTECTIVE ANTIGEN;
INTRAMUSCULAR INJECTION; INCUBATION PERIOD; ANTIBODY-RESPONSE;
RANDOMIZED-TRIAL; RHESUS MACAQUES; SAFETY; MEMORY
AB Protective antigen (PA)-specific antibody and cell-mediated immune (CMI) responses to annual and alternate booster schedules of anthrax vaccine adsorbed (AVA; BioThrax) were characterized in humans over 43 months. Study participants received 1 of 6 vaccination schedules: a 3-dose intramuscular (IM) priming series (0, 1, and 6 months) with a single booster at 42 months (4IM); 3-dose IM priming with boosters at 18 and 42 months (5-IM); 3-dose IM priming with boosters at 12, 18, 30, and 42 months (7-IM); the 1970 licensed priming series of 6 doses (0, 0.5, 1, 6, 12, and 18 months) and two annual boosters (30 and 42 months) administered either subcutaneously (SQ) (8-SQ) or IM (8-IM); or saline placebo control at all eight time points. Antibody response profiles included serum anti-PA IgG levels, subclass distributions, avidity, and lethal toxin neutralization activity (TNA). CMI profiles included frequencies of gamma interferon (IFN-gamma)- and interleukin 4 (IL-4)-secreting cells and memory B cells (MBCs), lymphocyte stimulation indices (SI), and induction of IFN-gamma, IL-2, IL-4, IL-6, IL-1 beta, and tumor necrosis factor alpha (TNF-alpha) mRNA. All active schedules elicited high-avidity PA-specific IgG, TNA, MBCs, and T cell responses with a mixed Th1-Th2 profile and Th2 dominance. Anti-PA IgG and TNA were highly correlated (e.g., month 7, r(2) = 0.86, P < 0.0001, log(10) transformed) and declined in the absence of boosters. Boosters administered IM generated the highest antibody responses. Increasing time intervals between boosters generated antibody responses that were faster than and superior to those obtained with the final month 42 vaccination. CMI responses to the 3-dose IM priming remained elevated up to 43 months.
C1 [Quinn, Conrad P.; Schiffer, Jarad M.; Semenova, Vera A.; Li, Han; Marano, Nina; Plikaytis, Brian D.; Wright, Jennifer G.] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Sabourin, Carol L.; Niemuth, Nancy A.; Rudge, Thomas L.; Brys, April M.] Battelle Mem Inst, Columbus, OH USA.
[Mittler, Robert S.; Ibegbu, Chris C.; Wrammert, Jens; Ahmed, Rafi] Emory Univ, Emory Vaccine Ctr, Atlanta, GA 30322 USA.
[Mittler, Robert S.; Ibegbu, Chris C.] Emory Univ, Yerkes Natl Primate Ctr, Atlanta, GA 30322 USA.
[Parker, Scott D.] Univ Alabama Birmingham, Birmingham, AL USA.
[Babcock, Janiine] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Keitel, Wendy; El Sahly, Hana] Baylor Coll Med, Houston, TX 77030 USA.
[Poland, Gregory A.; Jacobson, Robert M.] Mayo Clin, Rochester, MN USA.
[Keyserling, Harry L.] Emory Univ, Sch Med, Atlanta, GA USA.
RP Quinn, CP (reprint author), Ctr Dis Control & Prevent, Atlanta, GA USA.
EM cquinn@cdc.gov
FU HHS \ Centers for Disease Control and Prevention (CDC)
FX HHS vertical bar Centers for Disease Control and Prevention (CDC)
provided funding to Conrad P. Quinn, Carol Sabourin, Jarad M. Schiffer,
Nancy Niemuth, Vera Semenova, Han Li, Thomas L. Rudge, April Brys,
Robert S. Mittler, Chris Ibegbu, Jens Wrammert, Rafi Ahmed, Scott D.
Parker, Janiine Babcock, Wendy Keitel, Gregory A. Poland, Harry
Keyserling, Hana El Sahly, Robert M. Jacobson, Nina Marano, Brian D.
Plikaytis, and Jennifer Wright.
NR 36
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U1 4
U2 7
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 1556-6811
EI 1556-679X
J9 CLIN VACCINE IMMUNOL
JI Clin. Vaccine Immunol.
PD APR
PY 2016
VL 23
IS 4
BP 326
EP 338
DI 10.1128/CVI.00696-15
PG 13
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA DI4SY
UT WOS:000373490800009
PM 26865594
ER
PT J
AU Huh, J
Glisson, RR
Matsumoto, T
Easley, ME
AF Huh, Jeannie
Glisson, Richard R.
Matsumoto, Takumi
Easley, Mark E.
TI Biomechanical Comparison of Intramedullary Screw Versus Low-Profile
Plate Fixation of a Jones Fracture
SO FOOT & ANKLE INTERNATIONAL
LA English
DT Article
DE Jones fracture; intramedullary screw; fifth metatarsal; plate fixation
ID 5TH METATARSAL; 5TH-METATARSAL BASE; PROXIMAL 5TH-METATARSAL;
STRESS-FRACTURE; MANAGEMENT; STRAINS; DISTAL
AB Background: Intramedullary screw fixation of fifth metatarsal Jones fractures often produces satisfactory results, however, nonunion and refracture rates are not negligible. The low-profile hook plate is an alternative fixation method that has been promoted to offer improved rotational control at the fracture site, but this remains to be proven. The purpose of this study was to document biomechanical performance differences between this type of plate and a contemporary solid, dual-pitch intramedullary screw in a cadaveric Jones fracture model.
Methods: Simulated Jones fractures were created in 8 matched pairs of fresh-frozen cadaveric fifth metatarsals. One bone from each pair was stabilized using an intramedullary TriMed Jones Screw and the other using a TriMed Jones Fracture Plate (TriMed, Inc, Santa Clarita, CA). Controlled bending and torsional loads were applied. Bending stiffness and fracture site angulation, as well as torsional stiffness, peak torque, and fracture site rotation were quantified and compared.
Results: Intramedullary screw fixation demonstrated greater bending stiffness and less fracture site angulation than plate fixation during plantar-to-dorsal and lateral-to-medial bending. Torsional stiffness of screw-fixed metatarsals exceeded that of plate-fixed bones at initial loading; however, as rotation progressed, the plate resisted torque better than the screw. No difference in peak torque was demonstrable between fixation methods, but it was reached earlier in specimens fixed with screws and later in those fixed with plates as rotation progressed.
Conclusion: In this cadaveric Jones fracture model, intramedullary screw fixation demonstrated bending stiffness and resistance to early torsional loading that was superior to that offered by plate fixation.
Clinical Relevance: Although low-profile hook plates offer an alternative for fixation of fifth metatarsal Jones fractures, intramedullary screw fixation may provide better resistance to bending and initiation of fracture site rotation. The influence of these mechanical characteristics on fracture healing is unknown, and further clinical investigation is warranted.
C1 [Huh, Jeannie] Dwight D Eisenhower Army Med Ctr, Dept Orthopaed Surg, 300 East Hosp Rd, Ft Gordon, GA 30905 USA.
[Glisson, Richard R.; Easley, Mark E.] Duke Univ, Med Ctr, Dept Orthopaed Surg, Durham, NC USA.
[Matsumoto, Takumi] Univ Tokyo, Tokyo, Japan.
RP Huh, J (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Orthopaed Surg, 300 East Hosp Rd, Ft Gordon, GA 30905 USA.
EM jhandyh@gmail.com
FU TriMed (TriMed, Inc, Santa Clarita, CA)
FX The author(s) disclosed receipt of the following financial support for
the research, authorship, and/or publication of this article: This study
was funded by a research grant from TriMed (TriMed, Inc, Santa Clarita,
CA).
NR 22
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U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1071-1007
EI 1944-7876
J9 FOOT ANKLE INT
JI Foot Ankle Int.
PD APR
PY 2016
VL 37
IS 4
BP 411
EP 418
DI 10.1177/1071100715619678
PG 8
WC Orthopedics
SC Orthopedics
GA DI7GY
UT WOS:000373668700010
PM 26637274
ER
PT J
AU Wu, CC
Aubry, S
Arsenlis, A
Chung, PW
AF Wu, Chi-Chin
Aubry, Sylvie
Arsenlis, Athanasios
Chung, Peter W.
TI Binary dislocation junction formation and strength in hexagonal
close-packed crystals
SO INTERNATIONAL JOURNAL OF PLASTICITY
LA English
DT Article
DE Dislocations; Dynamics; Elastic material; Analytic functions
ID FCC METALS; FOREST INTERACTIONS; SINGLE-CRYSTALS; PRISMATIC SLIP;
MECHANISMS; DYNAMICS; PLASTICITY; SIMULATIONS; MODEL; STRESS
AB This work examines binary dislocation interactions, junction formation and junction strengths in hexagonal close-packed (hcp) crystals. Through a line-tension model and dislocation dynamics (DD) simulations, the interaction and dissociation of different sets of binary junctions are investigated involving one dislocation on the (01 (1) over bar0) prismatic plane and a second dislocation on one of the following planes: (0001) basal, (1 (1) over bar 00) prismatic, (1 (1) over bar 01) primary pyramidal, or ((2) over bar 112) secondary pyramidal. Varying pairs of Burgers vectors are chosen from among the common types: the basal type : 1/3 <11<(2)over bar>0 >, prismatic type :<0001>, and pyramidal type : 1/3 <11<(23)over bar> >. For binary interaction due to dislocation intersection, both the analytical results and DD-simulations indicate a relationship between symmetry of interaction maps and the relative magnitude of the Burgers vectors that constitute the junction. Using analytical formulae, a simple regressive model is also developed to represent the junction yield surface. The equation is treated as a degenerated super elliptical equation to quantify the aspect ratio and tilting angle. The results provide analytical insights on binary dislocation interactions that may occur in general hcp metals. (c) 2015 Elsevier Ltd. All rights reserved.
C1 [Wu, Chi-Chin] US Army Res Lab, Energet Mat Sci Branch, Lethal Div, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
[Aubry, Sylvie; Arsenlis, Athanasios] Lawrence Livermore Natl Lab, Div Mat Sci, POB 808,L-367, Livermore, CA 94551 USA.
[Chung, Peter W.] Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA.
[Chung, Peter W.] US Army Res Lab, Computat Sci Div, Computat & Informat Sci Directorate, Adelphi, MD 20783 USA.
RP Wu, CC (reprint author), US Army Res Lab, Energet Mat Sci Branch, Lethal Div, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
EM chi-chin.wu.ctr@mail.mil
OI Wu, Chi-Chin/0000-0002-6036-3271
FU Secure Mission Solutions, Inc. [N65235-06-D8847]; Oak Ridge Institute
for Science and Education Program in Maryland [ORISE-1120-1120-99]; U.S.
Department of Energy by Lawrence Livermore National Laboratory
[DE-AC52-07NA27344]; Computational Sciences Division of ARL; Army
Research Office [W911NF1410330]; Department of Mechanical Engineering,
University of Maryland at College Park
FX The corresponding author Chi-Chin Wu would like to acknowledge the
support from the Secure Mission Solutions, Inc. (N65235-06-D8847) and
Oak Ridge Institute for Science and Education Program in Maryland
(ORISE-1120-1120-99). The simulations in this article by authors Wu and
Chung were performed at the Computational and Information Sciences
Directorate (CISD) of US Army Research Laboratory (ARL) using the
computing resources provided by ARL High Performance Supercomputing
Resource Center (DSRC). The efforts of binary interaction maps by
authors Aubry and Arsenlis were performed under the auspices of the U.S.
Department of Energy by Lawrence Livermore National Laboratory under
contract No. DE-AC52-07NA27344. Author Chung would also like to
acknowledge partial support from the Computational Sciences Division of
ARL, the Army Research Office (W911NF1410330) and the Department of
Mechanical Engineering, University of Maryland at College Park.
NR 48
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U1 2
U2 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0749-6419
EI 1879-2154
J9 INT J PLASTICITY
JI Int. J. Plast.
PD APR
PY 2016
VL 79
BP 176
EP 195
DI 10.1016/j.ijplas.2015.12.003
PG 20
WC Engineering, Mechanical; Materials Science, Multidisciplinary; Mechanics
SC Engineering; Materials Science; Mechanics
GA DI5PK
UT WOS:000373550900007
ER
PT J
AU Zhu, JT
Ogden, FL
Lai, WC
Chen, XF
Talbot, CA
AF Zhu, Jianting
Ogden, Fred L.
Lai, Wencong
Chen, Xiangfeng
Talbot, Cary A.
TI An explicit approach to capture diffusive effects in finite
water-content method for solving vadose zone flow
SO JOURNAL OF HYDROLOGY
LA English
DT Article
DE Vadose zone flow; Finite water-content method; Water content bin;
Diffusivity; Explicit method
ID 1D RICHARDS EQUATION; POROUS-MEDIA; SOILS; INFILTRATION; DYNAMICS
AB Vadose zone flow problems are usually solved from the Richards equation. Solution to the Richards equation is generally challenging because the hydraulic conductivity and diffusivity in the equation are strongly non-linear functions of water content. The finite water-content method was proposed as an alternative general solution method of the vadose zone flow problem for infiltration, falling slugs, and vadose zone response to water table dynamics based on discretizing the water content domain into numerous bins instead of the traditional spatial discretization. In this study, we develop an improved approach to the original finite water-content method (referred to as TO method hereinafter) that better simulates diffusive effects but retains the robustness of the TO method. The approach treats advection and diffusion separately and considers diffusion on a bin by bin basis. After discretizing into water content bins, we treat the conductivity and diffusivity in individual bins as water content dependent constant evaluated at given water content corresponding to each bin. For each bin, we can solve the flow equations analytically since the hydraulic conductivity and diffusivity can be treated as a constant. We then develop solutions for each bin to determine the diffusive water amounts at each time step. The water amount ahead of the convective front for each bin is redistributed among water content bins to account for diffusive effects. The application of developed solution is straightforward only involving algebraic manipulations at each time step. The method can mainly improve water content profiles, but has no significant difference for the total infiltration rate and cumulative infiltration compared to the TO method. Although the method separately deals with advection and diffusion, it can account for the coupling effects of advection and diffusion reasonably well. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Zhu, Jianting; Ogden, Fred L.; Lai, Wencong; Chen, Xiangfeng] Univ Wyoming, Dept Civil & Architectural Engn, Laramie, WY 82071 USA.
[Lai, Wencong] Clemson Univ, Clemson, SC 29634 USA.
[Talbot, Cary A.] US Army, Corps Engineers, Engn Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA.
RP Zhu, JT (reprint author), Univ Wyoming, Dept Civil & Architectural Engn, Laramie, WY 82071 USA.
EM jzhu5@uwyo.edu
FU EPSCoR program [1135483]; NSF [EAR-1360384]; Smithsonian Tropical
Research Institute; Wyoming Center for Environmental Hydrology and
Geophysics (WyCEHG) EPSCoR Research Infrastructure Improvement (RII)
Track-1 project - NSF; University of Wyoming [1100-21266-2015]; U.S.
National Science Foundation (NSF)
FX This work was partly funded by the U.S. National Science Foundation
(NSF), EPSCoR program through cooperative agreement 1135483
Collaborative Research: CI-WATER, Cyberinfrastructure to Advance High
Performance Water Resource Modeling, NSF EAR-1360384 WSC-Category 2
Collaborative Research: Planning and Land Management in a Tropical
Ecosystem: Complexities of Land-use and Hydrology Coupling in the Panama
Canal Watershed, and the Smithsonian Tropical Research Institute, the
Wyoming Center for Environmental Hydrology and Geophysics (WyCEHG)
EPSCoR Research Infrastructure Improvement (RII) Track-1 project, funded
by NSF, and the Faculty Grant-In-Aid program at the University of
Wyoming (1100-21266-2015).
NR 21
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Z9 0
U1 2
U2 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-1694
EI 1879-2707
J9 J HYDROL
JI J. Hydrol.
PD APR
PY 2016
VL 535
BP 270
EP 281
DI 10.1016/j.jhydrol.2016.01.078
PG 12
WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources
SC Engineering; Geology; Water Resources
GA DI3TN
UT WOS:000373421500023
ER
PT J
AU Cheppudira, B
Christy, R
Clifford, J
AF Cheppudira, B.
Christy, R.
Clifford, J.
TI Antinociceptive effects of pluronic lecithin organo (PLO) opioid gels in
rats with thermal injury
SO JOURNAL OF PAIN
LA English
DT Meeting Abstract
C1 [Cheppudira, B.; Christy, R.; Clifford, J.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 1526-5900
J9 J PAIN
JI J. Pain
PD APR
PY 2016
VL 17
IS 4
SU 1
MA 358
BP S64
EP S65
PG 2
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA DI5EZ
UT WOS:000373523000257
PM 28162596
ER
PT J
AU Crossland, RF
Mitchell, A
Macko, AR
Aden, JK
Campbell, JE
Sheppard, FR
AF Crossland, Randy F.
Mitchell, Alex
Macko, Antoni R.
Aden, James K.
Campbell, James E.
Sheppard, Forest R.
TI Rapid assessment of shock in a nonhuman primate model of uncontrolled
hemorrhage: Association of traditional and nontraditional vital signs to
mortality risk
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article
DE Nonhuman primate; rhesus macaque; hemorrhagic shock; tissue oxygen
saturation; end-tidal carbon dioxide
ID TIDAL CARBON-DIOXIDE; NEAR-INFRARED SPECTROSCOPY; TISSUE
OXYGEN-SATURATION; CRITICALLY-ILL PATIENTS; TOTAL BLOOD-VOLUME; TRAUMA
PATIENTS; CARDIAC-OUTPUT; MICROCIRCULATORY ALTERATIONS; COMBAT CASUALTY;
RESUSCITATION
AB BACKGROUND Heart rate (HR), systolic blood pressure (SBP) and mean arterial pressure (MAP) are traditionally used to guide patient triage and resuscitation; however, they correlate poorly to shock severity. Therefore, improved acute diagnostic capabilities are needed. Here, we correlated acute alterations in tissue oxygen saturation (StO(2)) and end-tidal carbon dioxide (ETco(2)) to mortality in a rhesus macaque model of uncontrolled hemorrhage.
METHODS Uncontrolled hemorrhage was induced in anesthetized rhesus macaques by a laparoscopic 60% left-lobe hepatectomy (T = 0 minute). StO(2), ETco(2), HR, as well as invasive SBP and MAP were continuously monitored through T = 480 minutes. At T = 120 minutes, bleeding was surgically controlled, and blood loss was quantified. Data analyses compared nonsurvivors (expired before T = 480 minutes, n = 5) with survivors (survived to T = 480 minutes, n = 11) using repeated-measures analysis of variance with Bonferroni correction. All p < 0.05 was considered statistically significant. Results were reported as mean SEM.
RESULTS Baseline values were equivalent between groups for each parameter. In nonsurvivors versus survivors at T = 5 minutes, StO(2) (55% +/- 10% vs. 78% +/- 3%, p = 0.02) and ETco(2) (15 +/- 2 vs. 25 +/- 2 mm Hg, p = 0.0005) were lower, while MAP (18 +/- 1 vs. 23 +/- 2 mm Hg, p = 0.2), SBP (26 +/- 2 vs. 34 +/- 3 mm Hg, p = 0.4), and HR (104 +/- 13 vs. 105 +/- 6 beats/min, p = 0.3) were similar. Association of values over T = 5-30 minutes to mortality demonstrated StO(2) and ETco(2) equivalency with a significant group effect (p 0.009 for each parameter; R-2 = 0.92 and R-2 = 0.90, respectively). MAP and SBP associated with mortality later into the shock period (p < 0.04 for each parameter; R-2 = 0.91 and R-2 = 0.89, respectively), while HR yielded the lowest association (p = 0.8, R-2 = 0.83).
CONCLUSION Acute alterations in StO(2) and ETco(2) strongly associated with mortality and preceded those of traditional vital signs. The continuous, noninvasive aspects of Food and Drug Administration-approved StO(2) and ETco(2) monitoring devices provide logistical benefits over other methodologies and thus warrant further investigation.
C1 [Crossland, Randy F.; Mitchell, Alex; Macko, Antoni R.; Aden, James K.; Sheppard, Forest R.] JBSA Ft Sam Houston, Naval Med Res Unit San Antonio, San Antonio, TX USA.
[Aden, James K.] JBSA Ft Sam Houston, US Army, Inst Surg Res, San Antonio, TX USA.
RP Sheppard, FR (reprint author), JBSA Ft Sam Houston, Naval Med Res Unit San Antonio, Dept Expeditionary & Trauma Med, 3650 Chambers Pass,Bldg 3160, San Antonio, TX 78234 USA.
EM forest.r.sheppard.mil@mail.mil
FU Department of Defense through BUMED Advanced Medical Development
[G1017]; Office of Naval Research [G1018, G1318]
FX This work was funded by the Department of Defense through BUMED Advanced
Medical Development (Work Unit Number: G1017) and Office of Naval
Research (Work Unit Numbers: G1018 and G1318).
NR 50
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U1 3
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2163-0755
EI 2163-0763
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD APR
PY 2016
VL 80
IS 4
BP 610
EP 616
DI 10.1097/TA.0000000000000963
PG 7
WC Critical Care Medicine; Surgery
SC General & Internal Medicine; Surgery
GA DI1ED
UT WOS:000373237900012
PM 26808041
ER
PT J
AU Macko, AR
Crossland, RF
Cap, AP
Fryer, DM
Mitchell, TA
Pusateri, AE
Sheppard, FR
AF Macko, Antoni R.
Crossland, Randy F.
Cap, Andrew P.
Fryer, Darren M.
Mitchell, Thomas A.
Pusateri, Anthony E.
Sheppard, Forest R.
TI Control of severe intra-abdominal hemorrhage with an infusible
platelet-derived hemostatic agent in a nonhuman primate (rhesus macaque)
model
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article
DE NHP; xenogeneic; shock; infusible hemostatic; PDHA
ID REHYDRATED LYOPHILIZED PLATELETS; VON-WILLEBRAND-FACTOR; COMBAT CASUALTY
CARE; TOTAL BLOOD-VOLUME; DRIED PLATELETS; BLEEDING-TIME; TRAUMA;
XENOTRANSPLANTATION; ACTIVATION
AB BACKGROUND Hemorrhage remains the leading cause of potentially survivable trauma mortality. Recent reports indicate that injuries sustained in noncompressible anatomic locations (i.e., truncal and junctional) account for 86.5% of hemorrhage-related deaths. Infusible human platelet-derived hemostatic agents (hPDHAs) represent a promising strategy to reduce blood loss from noncompressible injuries. Here, we evaluate the hemostatic efficacy of a lyophilized hPDHA in a rhesus macaque model of severe, uncontrolled hemorrhage.
METHODS Hemorrhage was induced via laparoscopic 60% left-lobe hepatectomy in anesthetized rhesus macaques (T = 0 minute). Treatment infusion began with an 11-mL bolus (T = 5-6 minutes) of either 5% albumin solution (control; n = 8) or hPDHA (1.2 x 10(10) platelet equivalents, n = 8), followed by 2.8-mL/min 0.9% normal saline at T = 6-20 minutes. Resuscitation continued with normal saline (0.22 mL/kg/min) to a total volume of 20 mL/kg at T = 120 minutes, at which time surgical hemostasis was achieved and percent blood loss quantified. Animals were monitored until T = 480 minutes and then euthanized, and necropsy was performed with emphasis on intravascular and end-organ thrombi. Data are expressed as mean SEM; significance, p < 0.05.
RESULTS Both groups exhibited a approximate to 70% decrease in mean arterial pressure (MAP) from T = 0-5 minutes. Percent blood loss was 44.2 +/- 3.9% in hPDHA animals, and 44.3 +/- 3.3% in controls. Survival rates were 4 of 8 for hPDHA animals and 7 of 8 for controls. Regardless of treatment, percent blood loss was greater (p < 0.02) in nonsurviving animals (55 +/- 2%, n = 5) compared with surviving animals (42% +/- 3%, n = 11). No pathologic intravascular thrombi were observed in either group.
CONCLUSION The isolated administration of hPDHA did not significantly reduce blood loss; however, thrombocytopenia was not present in the model, and clinically, platelets would be administered in combination with plasma. Mortality was not statistically different between groups (p = 0.14) but was related to blood loss. Future studies should consider the use of hPDHA in combination with additional therapeutics (e.g., factors) and a model that incorporates thrombocytopenia or platelet dysfunction.
C1 [Macko, Antoni R.; Crossland, Randy F.; Fryer, Darren M.; Sheppard, Forest R.] JBSA Ft Sam Houston, Naval Med Res Unit San Antonio, San Antonio, TX USA.
[Cap, Andrew P.] JBSA Ft Sam Houston, US Army, Inst Surg Res, San Antonio, TX USA.
[Mitchell, Thomas A.] JBSA Ft Sam Houston San Antonio, San Antonio Mil Med Ctr, San Antonio, TX USA.
[Pusateri, Anthony E.] US Army, Med Res & Mat Command, Ft Detrick, MD USA.
RP Sheppard, FR (reprint author), JBSA Ft Sam Houston, Dept Expeditionary & Trauma Med, Naval Med Res Unit San Antonio, 3650 Chambers Pass,Bldg 3160, Ft Sam Houston, TX 78234 USA.
EM forest.r.sheppard.mil@mail.mil
FU Office of Naval Research [G1318]
FX This work was supported by the Office of Naval Research work unit number
G1318.
NR 28
TC 0
Z9 0
U1 3
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2163-0755
EI 2163-0763
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD APR
PY 2016
VL 80
IS 4
BP 617
EP 624
DI 10.1097/TA.0000000000000964
PG 8
WC Critical Care Medicine; Surgery
SC General & Internal Medicine; Surgery
GA DI1ED
UT WOS:000373237900013
PM 26808038
ER
PT J
AU Ciminera, P
Superior, MJ
Bullman, T
AF Ciminera, Paul
Superior, Michael J.
Bullman, Tim
TI Findings From the Department of Veterans Affairs Qarmat Ali Medical
Surveillance Program
SO MILITARY MEDICINE
LA English
DT Article
ID LUNG-CANCER MORTALITY; HEXAVALENT CHROMIUM; EXPOSURE; WORKERS; SMOKERS
AB Objective: To review the Veterans Affairs (VA) medical surveillance program for Veterans with potential hexavalent chromium (CrVI) exposure that occurred during 2003. Methods: Retrospective review of medical records of the 124 Veterans that participated in standardized, in-person clinical evaluations for possible CrVI exposure during the incident in question. The evaluations were reviewed to define population level effects. In addition, a mortality analysis was conducted for the 808 unique personal identifiers available to Veterans Health Administration. Results: Mean reported number of days exposed was 21 (median 10). A history of respiratory (n = 78) and skin (n = 38) symptoms were reported during the period of exposure. No abnormalities that were specific to chromium exposure (e.g., nasal septum perforation) were found. Eight deaths occurred between 2005 and 2012. Conclusions: The lack of severe nasal abnormalities in the VA evaluations supports a time-limited peak exposure. However, the overall low participation rate (15%) severely compromises any ability to generalize to the entire potentially exposed population. Regardless, since the actual level of exposure to CrVI will never be known with certainty, the VA will continue to monitor these Veterans with periodic evaluations to identify and manage any pathologic findings that might be associated with past CrVI exposure.
C1 [Ciminera, Paul; Bullman, Tim] Vet Hlth Adm, Post Deployment Hlth Off Publ Hlth, 810 Vermont Ave NW, Washington, DC 20420 USA.
[Superior, Michael J.] Reynolds Army Community Hosp, Dept Prevent Med, 4301 Wilson St, Ft Sill, OK 73503 USA.
RP Ciminera, P (reprint author), Vet Hlth Adm, Post Deployment Hlth Off Publ Hlth, 810 Vermont Ave NW, Washington, DC 20420 USA.
NR 14
TC 0
Z9 0
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD APR
PY 2016
VL 181
IS 4
BP 307
EP 310
DI 10.7205/MILMED-D-15-00278
PG 4
WC Medicine, General & Internal
SC General & Internal Medicine
GA DI3NO
UT WOS:000373405600005
PM 27046175
ER
PT J
AU Wickwire, EM
Williams, SG
Roth, T
Capaldi, VF
Jaffe, M
Moline, M
Motamedi, GK
Morgan, GW
Mysliwiec, V
Germain, A
Pazdan, RM
Ferziger, R
Balkin, TJ
MacDonald, ME
Macek, TA
Yochelson, MR
Scharf, SM
Lettieri, CJ
AF Wickwire, Emerson M.
Williams, Scott G.
Roth, Thomas
Capaldi, Vincent F.
Jaffe, Michael
Moline, Margaret
Motamedi, Gholam K.
Morgan, Gregory W.
Mysliwiec, Vincent
Germain, Anne
Pazdan, Renee M.
Ferziger, Reuven
Balkin, Thomas J.
MacDonald, Margaret E.
Macek, Thomas A.
Yochelson, Michael R.
Scharf, Steven M.
Lettieri, Christopher J.
TI Sleep, Sleep Disorders, and Mild Traumatic Brain Injury. What We Know
and What We Need to Know: Findings from a National Working Group
SO NEUROTHERAPEUTICS
LA English
DT Article
DE Sleep; Sleep disorders; Traumatic brain injury; Concussion; Insomnia;
Sleep apnea
ID RANDOMIZED CONTROLLED-TRIAL; COGNITIVE-BEHAVIORAL THERAPY; EXCESSIVE
DAYTIME SLEEPINESS; MINOR HEAD-INJURY; WAKE DISTURBANCES;
CEREBRAL-ISCHEMIA; QUALITY INDEX; REM-SLEEP; CLINICAL-SIGNIFICANCE;
MILITARY VETERANS
AB Disturbed sleep is one of the most common complaints following traumatic brain injury (TBI) and worsens morbidity and long-term sequelae. Further, sleep and TBI share neurophysiologic underpinnings with direct relevance to recovery from TBI. As such, disturbed sleep and clinical sleep disorders represent modifiable treatment targets to improve outcomes in TBI. This paper presents key findings from a national working group on sleep and TBI, with a specific focus on the testing and development of sleep-related therapeutic interventions for mild TBI (mTBI). First, mTBI and sleep physiology are briefly reviewed. Next, essential empirical and clinical questions and knowledge gaps are addressed. Finally, actionable recommendations are offered to guide active and efficient collaboration between academic, industry, and governmental stakeholders.
C1 [Wickwire, Emerson M.] Univ Maryland, Sch Med, Dept Psychiat, Baltimore, MD 21201 USA.
[Wickwire, Emerson M.; Scharf, Steven M.] Univ Maryland, Sch Med, Dept Med, Sleep Disorders Ctr,Div Pulm & Crit Care, Baltimore, MD 21201 USA.
[Williams, Scott G.] Walter Reed Natl Mil Med Ctr, Dept Med, Bethesda, MD USA.
[Williams, Scott G.; Mysliwiec, Vincent; Lettieri, Christopher J.] Uniformed Serv Univ Hlth Sci, Dept Med, Room A3060, Bethesda, MD 20814 USA.
[Roth, Thomas] Henry Ford Hosp, Sleep Disorders & Res Ctr, Detroit, MI 48202 USA.
[Capaldi, Vincent F.; Balkin, Thomas J.] Ctr Mil Psychiat & Neurosci Res, Walter Reed Army Inst Res, Dept Behav Biol, Silver Spring, MD USA.
[Jaffe, Michael] Univ Florida, Dept Neurol, Gainesville, FL USA.
[Jaffe, Michael] Univ Florida Trauma, Concuss & Sports Program, Gainesville, FL USA.
[Jaffe, Michael] UF Hlth Sleep Disorders Ctr, Gainesville, FL USA.
[Moline, Margaret] Eisai Inc, Woodcliff Lake, NJ USA.
[Motamedi, Gholam K.] Georgetown Univ Hosp, Dept Neurol, Washington, DC 20007 USA.
[Morgan, Gregory W.] Natl Intrepid Ctr Excellence, Sleep Disorders Ctr, Bethesda, MD USA.
[Mysliwiec, Vincent] San Antonio Mil Med Ctr, Dept Sleep Med, San Antonio, TX USA.
[Germain, Anne] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USA.
[Pazdan, Renee M.] US PHS, Ft Carson, CO USA.
[Ferziger, Reuven] Merck & Co Inc, Kenilworth, NJ USA.
[MacDonald, Margaret E.] Evans Army Community Hosp, Def & Vet Brain Injury Ctr, Gen Dynam Hlth Solut, Ft Carson, CO USA.
[Macek, Thomas A.] Takeda Dev Ctr Amer, CNS, Dept Clin Sci, Deerfield, IL USA.
[Yochelson, Michael R.] Medstar Natl Rehabil Network, Washington, DC USA.
[Yochelson, Michael R.] Georgetown Univ, Sch Med, Dept Neurol, Washington, DC USA.
[Yochelson, Michael R.] Georgetown Univ, Sch Med, Dept Rehabil Med, Washington, DC USA.
RP Wickwire, EM (reprint author), Univ Maryland, Sch Med, Dept Psychiat, Baltimore, MD 21201 USA.; Wickwire, EM (reprint author), Univ Maryland, Sch Med, Dept Med, Sleep Disorders Ctr,Div Pulm & Crit Care, Baltimore, MD 21201 USA.
EM ewickwire@medicine.umaryland.edu
NR 136
TC 2
Z9 2
U1 10
U2 17
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1933-7213
EI 1878-7479
J9 NEUROTHERAPEUTICS
JI Neurotherapeutics
PD APR
PY 2016
VL 13
IS 2
BP 403
EP 417
DI 10.1007/s13311-016-0429-3
PG 15
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA DI6WY
UT WOS:000373642100013
PM 27002812
ER
PT J
AU Herzog, MM
Driban, JB
Cattano, NM
Cameron, KL
Tourville, TW
Marshall, SW
Pietrosimone, B
AF Herzog, M. M.
Driban, J. B.
Cattano, N. M.
Cameron, K. L.
Tourville, T. W.
Marshall, S. W.
Pietrosimone, B.
TI RISK OF DEVELOPING KNEE OSTEOARTHRITIS OVER TWENTY-FOUR MONTHS IN
PARTICIPANTS THAT DECREASE WALKING SPEED DURING A TWELVE MONTH PERIOD:
AN ANALYSIS OF THE OSTEOARTHRITIS INITIATIVE
SO OSTEOARTHRITIS AND CARTILAGE
LA English
DT Meeting Abstract
CT World Congress of the Osteoarthritis-Research-Society-International
(OARSI) on Osteoarthritis
CY MAR 31-APR 03, 2016
CL Amsterdam, NETHERLANDS
SP Osteoarthritis Res Soc Int
C1 [Herzog, M. M.; Marshall, S. W.; Pietrosimone, B.] Univ N Carolina, Chapel Hill, NC USA.
[Driban, J. B.] Tufts Med Ctr, Boston, MA USA.
[Cattano, N. M.] West Chester Univ Penn, W Chester, PA USA.
[Cameron, K. L.] Keller Army Hosp, West Point, NY USA.
[Tourville, T. W.] Univ Vermont, Burlington, VT USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1063-4584
EI 1522-9653
J9 OSTEOARTHR CARTILAGE
JI Osteoarthritis Cartilage
PD APR
PY 2016
VL 24
SU S
MA 147
BP S94
EP S95
PG 2
WC Orthopedics; Rheumatology
SC Orthopedics; Rheumatology
GA DI5KW
UT WOS:000373538800177
ER
PT J
AU Rhon, D
Hando, B
Deyle, G
AF Rhon, D.
Hando, B.
Deyle, G.
TI USE OF PHYSICAL THERAPY AND CORTICOSTEROID INJECTIONS IN THE MANAGEMENT
OF KNEE OSTEOARTHRITIS IN THE US MILITARY HEALTH SYSTEM
SO OSTEOARTHRITIS AND CARTILAGE
LA English
DT Meeting Abstract
CT World Congress of the Osteoarthritis-Research-Society-International
(OARSI) on Osteoarthritis
CY MAR 31-APR 03, 2016
CL Amsterdam, NETHERLANDS
SP Osteoarthritis Res Soc Int
C1 [Rhon, D.; Deyle, G.] Brooke Army Med Ctr, San Antonio, TX USA.
[Hando, B.] Natl Def Univ, Washington, DC USA.
NR 0
TC 0
Z9 0
U1 3
U2 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1063-4584
EI 1522-9653
J9 OSTEOARTHR CARTILAGE
JI Osteoarthritis Cartilage
PD APR
PY 2016
VL 24
SU S
MA 400
BP S233
EP S234
PG 2
WC Orthopedics; Rheumatology
SC Orthopedics; Rheumatology
GA DI5KW
UT WOS:000373538800430
ER
PT J
AU Zubko, E
Videen, G
Hines, DC
Shkuratov, Y
AF Zubko, Evgenij
Videen, Gorden
Hines, Dean C.
Shkuratov, Yuriy
TI The positive-polarization of cometary comae
SO PLANETARY AND SPACE SCIENCE
LA English
DT Article
DE Polarization; Comets; Modeling
ID DISCRETE-DIPOLE APPROXIMATION; O1 HALE-BOPP; POLARIMETRIC OBSERVATIONS;
IMAGING POLARIMETRY; OPTICAL POLARIMETRY; LIGHT-SCATTERING; INFRARED
OBSERVATIONS; PHASE ANGLES; B2 HYAKUTAKE; HALLEY DUST
AB We examine the dispersion of the degree of linear polarization Pin comets at phase angle similar to 90 degrees where the maximum amplitude of positive polarization P-max, occurs. The range of polarization observed in comets is from 7% up to more than 30%, and this cannot be explained through depolarization by gaseous emissions. Instead, we suggest that the observed dispersion of P results from different properties in cometary dust. We simulate the spectral polarimetric observations of comets using model agglomerated debris particles. The vast majority of observations can be reproduced with a mixture of weakly absorbing and highly absorbing agglomerated debris particles, which obey the same power-law size distribution. Within this extremely simple approach, polarization at side-scattering angles in a given comet is governed by the relative abundance of weakly and strongly absorbing particles. We find that in comets with the highest polarization, the weakly absorbing particles appear in proportions of only 14-23% by volume; whereas, in comets with the lowest polarization P-max, their abundance is much greater, 82-95%. We conclude that the polarization at side-scattering angles unambiguously measures the relative abundance of Mg-rich silicates and refractory organics or amorphous carbon in comets. We put forth a hypothesis that low P-max could be an indicator for presence of a well-developed refractory surface layer covering cometary nucleus. 2015 Elsevier Ltd. All rights reserved.
C1 [Zubko, Evgenij; Shkuratov, Yuriy] Kharkov Natl Univ, Inst Astron, 35 Sumskaya St, UA-61022 Kharkov, Ukraine.
[Videen, Gorden; Hines, Dean C.] Space Sci Inst, 4750 Walnut St,Suite 205, Boulder, CO 80301 USA.
[Videen, Gorden] INTA, Ctra Ajalvir Km 4, Madrid 28850, Spain.
[Videen, Gorden] Univ Cantabria, Dept Fis Aplicada, Grp Opt, Fac Ciencias, Avda Los Castros S-N, E-39005 Santander, Spain.
[Videen, Gorden] US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
[Hines, Dean C.] Space Telescope Sci Inst, 3700 San Martin Dr, Baltimore, MD 21218 USA.
RP Zubko, E (reprint author), Kharkov Natl Univ, Inst Astron, 35 Sumskaya St, UA-61022 Kharkov, Ukraine.
EM evgenij.s.zubko@gmail.com
OI Zubko, Evgenij/0000-0001-9994-923X
FU NASA through Space Telescope Science Institute [GO 13199, 13474]; NASA
[NAS5-26555]
FX This work was partially supported by NASA through a Grant (GO 13199 and
13474) provided from the Space Telescope Science Institute, which is
operated by the Association of Universities for Research in Astronomy,
Inc., under NASA contract NAS5-26555. The authors thank Dr. Olexandra
Ivanova (Main Astronomical Observatory of NAS of Ukraine) for valuable
comments on this work, and two anonymous referees for their constructive
reviews.
NR 73
TC 1
Z9 1
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0032-0633
J9 PLANET SPACE SCI
JI Planet Space Sci.
PD APR
PY 2016
VL 123
SI SI
BP 63
EP 76
DI 10.1016/j.pss.2015.09.020
PG 14
WC Astronomy & Astrophysics
SC Astronomy & Astrophysics
GA DI3QZ
UT WOS:000373414900008
ER
PT J
AU House, JM
AF House, Jonathan M.
TI Intercept 1961: The Birth of Soviet Missile Defense.
SO RUSSIAN REVIEW
LA English
DT Book Review
C1 [House, Jonathan M.] US Army Command & Gen Staff Coll, Leavenworth, KS 66027 USA.
RP House, JM (reprint author), US Army Command & Gen Staff Coll, Leavenworth, KS 66027 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0036-0341
EI 1467-9434
J9 RUSS REV
JI Russ. Rev.
PD APR
PY 2016
VL 75
IS 2
BP 333
EP 334
PG 2
WC History
SC History
GA DI6LL
UT WOS:000373610300032
ER
PT J
AU Marsh, C
AF Marsh, Christopher
TI The Two Pluralisms Under the Third Rome
SO SOCIETY
LA English
DT Article
DE Russia; Forced secularization; Desecularization; Russian Orthodox
Christianity; Peter Berger
AB This article applies Berger's new paradigm for religion in a pluralist age to the case of Russia, a society that underwent 70 years forced secularization and yet today displays great religious diversity. The analysis rests upon two major assumptions. The first is that of "multiple secularities," meaning that societies that arrive at secularity may arrive there from very different points of departure and by following very different secularization paths, and the particular paths taken are of considerable consequence. Second is the assumption that Russia's history of forced secularization continues to have profound implications on all aspects of the sacred and the secular in Russia today. This is explored in the areas of church-state relations; religious belief; religion and national identity; and the implications of these on what Berger calls "formulas for peace." Throughout the analysis, Berger's theory proves quite valuable and offers several useful lenses through which to view the relationship between the sacred and the secular in today's Russia.
C1 [Marsh, Christopher] US Army, Sch Adv Mil Studies, 201 Reynolds Ave, Ft Leavenworth, KS 66027 USA.
RP Marsh, C (reprint author), US Army, Sch Adv Mil Studies, 201 Reynolds Ave, Ft Leavenworth, KS 66027 USA.
EM christopher.marsh5@us.army.mil
NR 18
TC 0
Z9 0
U1 3
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0147-2011
EI 1936-4725
J9 SOCIETY
JI Society
PD APR
PY 2016
VL 53
IS 2
BP 123
EP 130
DI 10.1007/s12115-016-9987-6
PG 8
WC Social Sciences, Interdisciplinary; Sociology
SC Social Sciences - Other Topics; Sociology
GA DI1CS
UT WOS:000373234200003
ER
PT J
AU Thomas, DM
Branch, KR
Cury, RC
AF Thomas, Dustin M.
Branch, Kelley R.
Cury, Ricardo C.
TI PROMISE of Coronary CT Angiography: Precise and Accurate Diagnosis and
Prognosis in Coronary Artery Disease
SO SOUTHERN MEDICAL JOURNAL
LA English
DT Review
DE Scottish Computed Tomography of the Heart Trial; coronary computed
tomography angiography; coronary artery disease; Prospective Multicenter
Imaging Study for Evaluation of Chest Pain
ID COMPUTED TOMOGRAPHIC ANGIOGRAPHY; INTERNATIONAL MULTICENTER REGISTRY;
AMERICAN-HEART-ASSOCIATION; ALL-CAUSE MORTALITY; CARDIOVASCULAR
ANGIOGRAPHY; MYOCARDIAL-INFARCTION; THORACIC SURGEONS;
CLINICAL-OUTCOMES; MEDICAL THERAPY; TASK-FORCE
AB Coronary computed tomography angiography (CCTA) is a rapidly growing and powerful diagnostic test that offers a great deal of precision with respect to diagnosing coronary artery disease (CAD). Guideline statements for patients with stable ischemic heart disease have recommended CCTA for only a limited portion of intermediate-risk patients who have relative or absolute contraindications for exercise or vasodilator stress testing. The publication of two large, prospective randomized clinical trials, the Prospective Multicenter Imaging Study for Evaluation of Chest Pain and the Scottish Computed Tomography of the Heart Trial are likely to expand these indications. These new data from large trials, in addition to other studies, show that CCTA is highly sensitive for the detection of CAD, identifies high-risk patients for cardiac events based on extent or plaque morphology of CAD that would not be identified by other noninvasive means, and provides significantly greater diagnostic certainty for proper treatment, including referral for invasive coronary angiography with revascularization more appropriately. Superior diagnostic accuracy and prognostic data with CCTA, when compared with other functional stress tests, may result in a reduction in unnecessary downstream testing and cost savings. In addition, newer CCTA applications hold the promise of providing a complete evaluation of a patient's coronary anatomy as well as a per-vessel ischemic evaluation. This review focuses on the interval knowledge obtained from newer data on CCTA in patients with stable ischemic heart disease, primarily focusing on the contributions of the Prospective Multicenter Imaging Study for Evaluation of Chest Pain and the Scottish Computed Tomography of the Heart Trial.
C1 [Thomas, Dustin M.] Brooke Army Med Ctr, Div Cardiol, 3551 Roger Brooke Dr, San Antonio, TX 78234 USA.
Univ Washington, Div Cardiol, Seattle, WA 98195 USA.
Baptist Hlth South Florida, Miami Cardiac & Vasc Inst, Miami, FL USA.
RP Thomas, DM (reprint author), Brooke Army Med Ctr, Div Cardiol, 3551 Roger Brooke Dr, San Antonio, TX 78234 USA.
EM dustin.m.thomas4.mil@mail.mil
NR 42
TC 0
Z9 0
U1 1
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0038-4348
EI 1541-8243
J9 SOUTH MED J
JI South.Med.J.
PD APR
PY 2016
VL 109
IS 4
BP 242
EP 247
DI 10.14423/SMJ.0000000000000436
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA DI1UT
UT WOS:000373282400011
PM 27043808
ER
PT J
AU Walsh, DV
Robinson, J
Jurek, GM
Capo-Aponte, JE
Riggs, DW
Temme, LA
AF Walsh, David V.
Robinson, James
Jurek, Gina M.
Capo-Aponte, Jose E.
Riggs, Daniel W.
Temme, Leonard A.
TI A Performance Comparison of Color Vision Tests for Military Screening
SO AEROSPACE MEDICINE AND HUMAN PERFORMANCE
LA English
DT Article
DE military; aviation
ID FARNSWORTH LANTERN TEST; QUANTIFICATION
AB BACKGROUND: Current color vision (CV) tests used for aviation screening in the U.S. Army only provide pass-fail results, and previous studies have shown variable sensitivity and specificity. The purpose of this study was to evaluate seven CV tests to determine an optimal CV test screener that potentially could be implemented by the U.S. Army.
METHODS: There were 133 subjects [65 Color Vision Deficits (CVD), 68 Color Vision Normal (CVN)] who performed all of the tests in one setting. CVD and CVN determination was initially assessed with the Oculus anomaloscope. Each test was administered monocularly and according to the test protocol.The main outcome measures were test sensitivity, specificity, and administration time (automated tests).
RESULTS: Three of the four Pseudoisochromatic Plate (PIP) tests had a sensitivity/specificity > 0.90 OD/OS, whereas the FALANT tests had a sensitivity/specificity > 0.80 OD/OS. The Cone Contrast Test (CCT) demonstrated sensitivity/specificity > 0.90 OD/OS, whereas the Color Assessment and Diagnosis (CAD) test demonstrated sensitivity/specificity > 0.85 OD/OS. Comparison with the anomaloscope ("gold standard") revealed no significant difference of sensitivity and specificity OD/OS with the CCT, Dvorine PIP, and PIPC tests. Finally, the CCT administration time was significantly faster than the CAD test.
DISCUSSION: The current U.S. Army CV screening tests demonstrated good sensitivity and specificity, as did the automated tests. In addition, some current PIP tests (Dvorine, PIPC), and the CCT performed no worse statistically than the anomaloscope with regard to sensitivity/specificity. The CCT letter presentation is randomized and results would not be confounded by potential memorization, or fading, of book plates.
C1 [Walsh, David V.] US Army, Vis Protect & Performance Div, Aeromed Res Lab, 6901 Farrel Rd, Ft Rucker, AL 36362 USA.
Carl R Darnall Army Med Ctr, Optometry Clin, Ft Hood, TX USA.
Womack Army Med Ctr, Dept Optometry, Ft Bragg, NC USA.
RP Walsh, DV (reprint author), US Army, Vis Protect & Performance Div, Aeromed Res Lab, 6901 Farrel Rd, Ft Rucker, AL 36362 USA.
EM david.v.walsh.mil@mail.mil
FU Postgraduate Research Participation Program at the U. S. Army
Aeromedical Research Laboratory
FX This research was sponsored in part by the Postgraduate Research
Participation Program at the U. S. Army Aeromedical Research Laboratory
administered by the Oak Ridge Institute of Science and Education through
an interagency agreement with the U.S. Department of Energy and USAMRMC.
NR 18
TC 0
Z9 0
U1 0
U2 0
PU AEROSPACE MEDICAL ASSOC
PI ALEXANDRIA
PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA
SN 2375-6314
EI 2375-6322
J9 AEROSP MED HUM PERF
JI Aerosp. Med.Hum. Perform.
PD APR
PY 2016
VL 87
IS 4
BP 382
EP 387
DI 10.3357/AMHP.4391.2016
PG 6
WC Biophysics; Public, Environmental & Occupational Health; Medicine,
Research & Experimental
SC Biophysics; Public, Environmental & Occupational Health; Research &
Experimental Medicine
GA DH4RA
UT WOS:000372771900005
PM 27026122
ER
PT J
AU Eastwood, G
Loaiza, JR
Pongsiri, MJ
Sanjur, OI
Pecor, JE
Auguste, AJ
Kramer, LD
AF Eastwood, Gillian
Loaiza, Jose R.
Pongsiri, Montira J.
Sanjur, Oris I.
Pecor, James E.
Auguste, Albert J.
Kramer, Laura D.
TI Enzootic Arbovirus Surveillance in Forest Habitat and Phylogenetic
Characterization of Novel Isolates of Gamboa Virus in Panama
SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Article
ID VENEZUELAN EQUINE ENCEPHALITIS; AEDEOMYIA-SQUAMIPENNIS; YELLOW-FEVER;
MOSQUITOS DIPTERA; CULICIDAE; AMERICA; IDENTIFICATION; BUNYAVIRUSES;
TRANSMISSION; DIVERSITY
AB Landscape changes occurring in Panama, a country whose geographic location and climate have historically supported arbovirus transmission, prompted the hypothesis that arbovirus prevalence increases with degradation of tropical forest habitats. Investigations at four variably degraded sites revealed a diverse array of potential mosquito vectors, several of which are known vectors of arbovirus pathogens. Overall, 675 pools consisting of 25,787 mosquitoes and representing 29 species from nine genera (collected at ground and canopy height across all habitats) were screened for cytopathic viruses on Vero cells. We detected four isolates of Gamboa virus (family: Bunyaviridae; genus: Ortho-bunyavirus) from pools of Aedeomyia squamipennis captured at canopy level in November 2012. Phylogenetic characterization of complete genome sequences shows the new isolates to be closely related to each other with strong evidence of reassortment among the M segment of Panamanian Gamboa isolates and several other viruses of this group. At the site yielding viruses, Soberania National Park in central Panama, 18 mosquito species were identified, and the predominant taxa included A. squamipennis, Coquillettidia nigricans, and Mansonia titillans.
C1 [Eastwood, Gillian; Kramer, Laura D.] New York State Dept Hlth, Wadsworth Ctr, Slingerlands, NY USA.
[Loaiza, Jose R.] Inst Invest Cient & Serv Alta Tecnol INDICASAT, Ciudad Del Saber, Panama.
[Pongsiri, Montira J.] US EPA, Washington, DC 20460 USA.
Smithsonian Trop Res Inst, Panama City, Panama.
Walter Reed Biosystemat Unit, Suitland, MD USA.
[Auguste, Albert J.] Univ Texas Med Branch, Dept Pathol, Keiller Bldg, Galveston, TX 77555 USA.
[Sanjur, Oris I.] Smithsonian Trop Res Inst, Mol Biol & Evolut Labs, Ancon, Panama.
[Pecor, James E.] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Dept Entomol, Washington, DC 20307 USA.
RP Eastwood, G (reprint author), Univ Texas Med Branch, Dept Pathol, Keiller Bldg, Galveston, TX 77555 USA.
EM gieastwo@utmb.edu; jloaiza@indicasat.org.pa; pongsiri.montira@epa.gov;
sanjuro@si.edu; pecorj@si.edu; ajlaugus@utmb.edu;
laura.kramer@health.ny.gov
FU Robert E. Shope International Fellowship Award - American Society of
Tropical Medicine and Hygiene; James W. McLaughlin Endowment fund;
National Research Investigator Board (SNI) of the Secretariat for
Science, Technology and Innovation of Panama (SENACYT); U.S.
Environmental Protection Agency [DW33-92296801-0]
FX Funding for this project was provided via the Robert E. Shope
International Fellowship Award granted by the American Society of
Tropical Medicine and Hygiene to Gillian Eastwood in 2012. Gillian
Eastwood and Albert J. Auguste are also funded by the James W.
McLaughlin Endowment fund. Jose R. Loaiza is funded by the National
Research Investigator Board (SNI) of the Secretariat for Science,
Technology and Innovation of Panama (SENACYT). The U.S. Environmental
Protection Agency project "Mosquito Species Diversity and Landscape
Change DW33-92296801-0" awarded to Montira Pongsiri covered the costs of
mosquito sampling at Las Pavas, Achiote, and Barro Colorado Island, and
some of the laboratory supplies and reagents used at NYSDOH.
NR 45
TC 0
Z9 0
U1 3
U2 3
PU AMER SOC TROP MED & HYGIENE
PI MCLEAN
PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA
SN 0002-9637
EI 1476-1645
J9 AM J TROP MED HYG
JI Am. J. Trop. Med. Hyg.
PD APR
PY 2016
VL 94
IS 4
BP 786
EP 793
DI 10.4269/ajtmh.15-0445
PG 8
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA DI1FQ
UT WOS:000373242400015
PM 26834200
ER
PT J
AU Larson, GJ
Menzies, J
Lawson, DE
Evenson, EB
Hopkins, NR
AF Larson, Grahame J.
Menzies, John
Lawson, Daniel E.
Evenson, Edward B.
Hopkins, Nathan R.
TI Macro- and micro-sedimentology of a modern melt-out till - Matanuska
Glacier, Alaska, USA
SO BOREAS
LA English
DT Article
ID LAURENTIDE ICE-SHEET; RICH BASAL ICE; FREEZE-ON MECHANISM; SUBGLACIAL
TILL; DEPOSITIONAL PROCESSES; SOUTHEAST ICELAND; CENTRAL POLAND; END
MORAINES; DEFORMATION; SEDIMENTATION
AB The macro- and micro-sedimentology of a supraglacial melt-out till forming at the Matanuska Glacier was examined in relationship to the properties of the stratified basal zone ice and debris from which it is originating. In situ melting of the basal ice has produced a laminated to bedded diamicton consisting mainly of silt. Macroscopic properties include: discontinuous laminae and beds; lenses of sand, silt aggregates and open-work gravel; deformed and elongate clasts of clay; widely dispersed pebbles and cobbles, those that are prolate usually with their long axes subparallel to parallel to the bedding. Evidence for deformation is absent except for localized bending of beds over or under rock clasts. Microscopic properties are a unique element of this work and include: discontinuous lineations; silt to granule size laminae; prolate coarse sand and rock fragments commonly with their long axis subparallel to bedding; subangular to subrounded irregular shaped clay clasts often appearing as bands; sorted and unsorted silt to granule size horizons, sometimes disrupted by pore-water pathways. Limited deformation occurs around rock clasts and thicker parts of lamina. This study shows that insitu melting of debris-rich basal ice can produce a laminated and bedded diamicton that inherits and thereby preserves stratified basal ice properties. Production and preservation of supraglacial melt-out till require insitu melting of a stagnant, debris-rich basal ice source with a low relief surface that becomes buried by a thick, stable, insulating cover of ice-marginal sediment. Also required are a slow melt rate and adequate drainage to minimize pore-water pressures in the till and overlying sediment cover to maintain stability and uninterrupted deposition. Many modern and ancient hummocky moraines down glacier of subglacial overdeepenings probably meet these process criteria and their common occurrence suggests that both modern and pre-modern supraglacial melt-out tills may be more common than previously thought.
C1 [Larson, Grahame J.] Michigan State Univ, Dept Geol Sci, E Lansing, MI 48823 USA.
[Menzies, John] Brock Univ, Dept Earth Sci, St Catharines, ON L2S 3A1, Canada.
[Lawson, Daniel E.] ERDC Cold Reg Res & Engn Lab, Hanover, NH 03755 USA.
[Evenson, Edward B.; Hopkins, Nathan R.] Lehigh Univ, Dept Earth & Environm Sci, Bethlehem, PA 18015 USA.
RP Larson, GJ (reprint author), Michigan State Univ, Dept Geol Sci, E Lansing, MI 48823 USA.
EM larsong@msu.edu
FU NSF [OPP 9530757]
FX The authors wish to thank Bill Stevenson of Glacier Park Resort for his
years of logistical support and service as our pilot. The authors also
wish to thank Marty Ouellette for the production of thin sections and
Mike Lozon for his excellent draughtsmanship. The fieldwork was
supported by NSF Grant OPP 9530757 to Evenson, Larson and Lawson. We
thank Jonathan Lee of the British Geological Survey and an anonymous
reviewer for their comments and criticism that led to improvements in
our manuscript.
NR 108
TC 0
Z9 0
U1 3
U2 7
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0300-9483
EI 1502-3885
J9 BOREAS
JI Boreas
PD APR
PY 2016
VL 45
IS 2
BP 235
EP 251
DI 10.1111/bor.12149
PG 17
WC Geography, Physical; Geosciences, Multidisciplinary
SC Physical Geography; Geology
GA DH7ZJ
UT WOS:000373012500004
ER
PT J
AU Piccirillo, AL
Packnett, ER
Cowan, DN
Boivin, MR
AF Piccirillo, Amanda L.
Packnett, Elizabeth R.
Cowan, David N.
Boivin, Michael R.
TI Risk factors for disability discharge in enlisted active duty Army
soldiers
SO DISABILITY AND HEALTH JOURNAL
LA English
DT Article
DE Disability evaluation; Military personnel; Army personnel; Screening
ID US ARMY; MARINE CORPS; TEMPORAL TRENDS; UNITED-STATES; U.S. ARMY;
RETIREMENT; MILITARY; ADULTS; EPIDEMIOLOGY; PERSONNEL
AB Background: The rate of permanent disability retirement in U.S. Army soldiers and the prevalence of combat-related disabilities have significantly increased over time. Prior research on risk factors associated with disability retirement included soldiers retired prior to conflicts in Iraq and Afghanistan.
Objective: To identify risk factors for disability discharge among soldiers enlisted in the U.S. Army during military operations in Iraq and Afghanistan.
Methods: In this case-control study, cases included active duty soldiers evaluated for disability discharge. Controls, randomly selected from soldiers with no history of disability evaluation, were matched to cases based on enlistment year and sex. Conditional logistic regression models calculated odds of disability discharge. Attributable fractions estimated burden of disability for specific pre-existing condition categories. Poisson regression models compared risk of disability discharge related to common disability types by deployment and combat status.
Results: Characteristics at military enlistment with increased odds of disability discharge included a pre-existing condition, increased age or body mass index, white race, and being divorced. Musculoskeletal conditions and overweight contributed the largest proportion of disabilities. Deployment was protective against disability discharge or receiving a musculoskeletal-related disability, but significantly increased the risk of disability related to a psychiatric or neurological condition.
Conclusions: Soldiers with a pre-existing condition at enlistment, particularly a musculoskeletal condition, had increased odds of disability discharge. Risk of disability was dependent on condition category when stratified by deployment and combat status. Additional research examining conditions during pre-disability hospitalizations could provide insight on specific conditions that commonly lead to disability discharge. (c) 2016 Elsevier Inc. All rights reserved.
C1 [Piccirillo, Amanda L.; Packnett, Elizabeth R.; Cowan, David N.; Boivin, Michael R.] Walter Reed Army Inst Res, Prevent Med Branch, Dept Epidemiol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
[Piccirillo, Amanda L.; Packnett, Elizabeth R.; Cowan, David N.] ManTech Int Corp, ManTech Hlth, 13755 Sunrise Valley Dr,Suite 500, Herndon, VA 20171 USA.
RP Boivin, MR (reprint author), Walter Reed Army Inst Res, Prevent Med Branch, Dept Epidemiol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM michael.r.boivin2.mil@mail.mil
FU Defense Health Program
FX This study was supported by funds provided by the Defense Health
Program. This funding source had no additional involvement in any stage
of this study.
NR 23
TC 0
Z9 0
U1 1
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1936-6574
EI 1876-7583
J9 DISABIL HEALTH J
JI Disabil. Health J.
PD APR
PY 2016
VL 9
IS 2
BP 324
EP 331
DI 10.1016/j.dhjo.2015.11.005
PG 8
WC Health Care Sciences & Services; Health Policy & Services; Public,
Environmental & Occupational Health; Rehabilitation
SC Health Care Sciences & Services; Public, Environmental & Occupational
Health; Rehabilitation
GA DH3WT
UT WOS:000372718200022
PM 26905973
ER
PT J
AU Dar, RA
Giri, L
Karna, SP
Srivastava, AK
AF Dar, Riyaz A.
Giri, Lily
Karna, Shashi P.
Srivastava, Ashwini K.
TI Performance of palladium nanoparticle-graphene composite as an efficient
electrode material for electrochemical double layer capacitors
SO ELECTROCHIMICA ACTA
LA English
DT Article
DE Graphene; Palladium nanoparticles; Supercapacitors; Energy density
ID ENERGY-STORAGE PROPERTIES; GRAPHITE OXIDE; SUPERCAPACITOR ELECTRODES;
NANOSTRUCTURED MATERIALS; RAMAN-SPECTROSCOPY; FACILE SYNTHESIS; CARBON
MATERIALS; NANOSHEETS; REDUCTION; SHEETS
AB Palladium nanoparticle-graphene nanosheet composite (PdNP-GN) is demonstrated as an efficient electrode material in energy storage applications in supercapacitors. Palladium nanoparticle (PdNP) decorated graphene nanosheet (GN) composite was synthesized via a chemical approach in a single step by the simultaneous reduction of graphene oxide (GO) and palladium chloride from the aqueous phase using ascorbic acid as reducing agent. The materials were characterized by scanning and high resolution transmission electron microscopy, Raman, X-ray diffraction and energy dispersive X-ray spectroscopy which demonstrate that the metal nanoparticles have been uniformly deposited on the surface of graphene nanosheets. The synthesized material has been analyzed by cyclic voltammetry, electrochemical impedance spectrometry and chronopotentiometry using 1 M KCl as the supporting electrolyte for its application in electrochemical double layer supercapacitors. PdNPs-GN composite showed improved electron transfer kinetics and superior capacitive performance with large specific capacitance of 637 F g (1), excellent cyclic performance and maximum energy and power densities of 56 Wh kg (1) and 1166 W kg (1), respectively at a current density of 1.25 A g (1). This highlights the importance of the synergetic effects of electrochemically efficient Pd nanoparticles and graphene for energy storage applications in supercapacitors. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Dar, Riyaz A.; Srivastava, Ashwini K.] Univ Bombay, Dept Chem, Bombay 400098, Maharashtra, India.
[Giri, Lily; Karna, Shashi P.] US Army Res Lab, Weap & Mat Res Lab, RDRL WM, Aberdeen Proving Ground, MD 21005 USA.
[Dar, Riyaz A.] Maharashtra Coll Arts Sci & Commerce, Dept Chem, Bombay 400008, Maharashtra, India.
RP Srivastava, AK (reprint author), Univ Bombay, Dept Chem, Bombay 400098, Maharashtra, India.
EM aksrivastava@chem.mu.ac.in
FU University Grants Commission, New Delhi, India; Research Participation
Program at the U.S. Army Research Laboratory (US ARL)
FX The authors are thankful to University Grants Commission, New Delhi,
India for financial assistance under its Dr. D. S. Kothari Post
doctorate fellowship scheme (RAD). This research by one of us (L. G.)
was supported in part by an appointment to the Research Participation
Program at the U.S. Army Research Laboratory (US ARL) administered by
the Oak Ridge Institute for Science and Education through an interagency
agreement between the U.S. Department of Energy and US ARL.
NR 62
TC 3
Z9 3
U1 17
U2 45
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0013-4686
EI 1873-3859
J9 ELECTROCHIM ACTA
JI Electrochim. Acta
PD APR 1
PY 2016
VL 196
BP 547
EP 557
DI 10.1016/j.electacta.2016.02.197
PG 11
WC Electrochemistry
SC Electrochemistry
GA DH6CA
UT WOS:000372877400059
ER
PT J
AU Dos Santos, RF
Shah, S
Boedihardjo, A
Chen, F
Lu, CT
Butler, P
Ramakrishnan, N
AF Dos Santos, Raimundo F., Jr.
Shah, Sumit
Boedihardjo, Arnold
Chen, Feng
Lu, Chang-Tien
Butler, Patrick
Ramakrishnan, Naren
TI A framework for intelligence analysis using spatio-temporal storytelling
SO GEOINFORMATICA
LA English
DT Article
DE Spatial-temporal systems; Entity relationship modeling; Social media
networks; Spatial and physical reasoning; Semantic networks
AB Social media have ushered in alternative modalities to propagate news and developments rapidly. Just as traditional IR matured to modeling storylines from search results, we are now at a point to study how stories organize and evolve in additional mediums such as Twitter, a new frontier for intelligence analysis. This study takes as input news articles as well as social media feeds and extracts and connects entities into interesting storylines not explicitly stated in the underlying data. First, it proposes a novel method of spatio-temporal analysis on induced concept graphs that models storylines propagating through spatial regions in a time sequence. Second, it describes a method to control search space complexity by providing regions of exploration. And third, it describes ConceptRank as a ranking strategy that differentiates strongly-typed connections from weakly-bound ones. Extensive experiments on the Boston Marathon Bombings of April 15, 2013 as well as socio-political and medical events in Latin America, the Middle East, and the United States demonstrate storytelling's high application potential, showcasing its use in event summarization and association analysis that identifies events before they hit the newswire.
C1 S Army Corps Engn Geospatial Res Lab, Alexandria, VA USA.
Virginia Tech Comp Sci Dept, Falls Church, VA 22043 USA.
State Univ New York SUNY, Albany, NY USA.
[Dos Santos, Raimundo F., Jr.; Boedihardjo, Arnold] US Army, Corps Engineers Geospatial Res Lab, Alexandria, VA USA.
[Shah, Sumit; Lu, Chang-Tien; Butler, Patrick; Ramakrishnan, Naren] Virginia Tech, Dept Comp Sci, 7054 Haycock Rd, Falls Church, VA 22043 USA.
[Chen, Feng] SUNY Albany, Albany, NY 12222 USA.
RP Dos Santos, RF (reprint author), US Army, Corps Engineers Geospatial Res Lab, Alexandria, VA USA.
EM rdossant@vt.edu; sshah@vt.edu; arnold.p.boedihardjo@usace.army.mil;
fchen5@albany.edu; ctlu@vt.edu; pabutler@vt.edu; naren@vt.edu
OI Dos Santos, Ray/0000-0001-6495-803X
NR 29
TC 0
Z9 0
U1 3
U2 13
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1384-6175
EI 1573-7624
J9 GEOINFORMATICA
JI Geoinformatica
PD APR
PY 2016
VL 20
IS 2
BP 285
EP 326
DI 10.1007/s10707-015-0236-8
PG 42
WC Computer Science, Information Systems; Geography, Physical
SC Computer Science; Physical Geography
GA DH9YR
UT WOS:000373152400006
ER
PT J
AU Song, SA
Tolisano, AM
Cable, BB
Camacho, M
AF Song, Sungjin A.
Tolisano, Anthony M.
Cable, Benjamin B.
Camacho, Macario
TI Neurocognitive outcomes after pediatric adenotonsillectomy for
obstructive sleep apnea: A systematic review and meta-analysis
SO INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
LA English
DT Review
DE Tonsillectomy; Adenotonsillectomy; Neurocognitive; Systematic review;
Meta-analysis
ID QUALITY-OF-LIFE; CLINICAL-PRACTICE GUIDELINE; CHILDREN; BEHAVIOR;
TONSILLECTOMY; COGNITION; IMPACT; ADENOIDECTOMY; PERFORMANCE; DEFICITS
AB Objective: To provide an up-to-date systematic review and critical appraisal of prospectively performed studies evaluating neurocognitive function in children treated with adenotonsillectomy.
Data sources: PubMed/MEDLINE, Scopus, Web of Science, and the Cochrane Library.
Review methods: Searches were performed from inception through September 2, 2015.
Results: Nineteen prospective studies (898 adenotonsillectomy patients) met criteria and reported neurocognitive outcomes. The average age of children was 6.6 +/- 2.3 years (range 2.5-14 years) and 51.1% were male. Pre- and post-operative data utilizing the Neuropsychological Developmental Assessment score demonstrated an increase from a means + standard deviations of 101.5 +/- 14.7 [95% CI 100.0, 103.0] to 108.8 +/- 13.4 [95% CI 107.4, 110.2], p-value <0.0001 (375 children, three studies). Pre- and post-operative data utilizing the Stanford-Binet Intelligence Scales (IQ) demonstrated an increase in IQ scores from a means standard deviations of 97.1 +/- 13.8 [95% CI 91.6, 95.4] to 100.7 +/- 11.1 [95% CI 100.4,103.4], p-value <0.0001 (254 children, three studies). The mean pre- and post-adenotonsillectomy apnea-hypopnea index (AHI) decreased from 8.0 to 1.8 (274 children, six studies).
Conclusions: This meta-analysis found an improvement in neurocognitive function and IQafter pediatric adenotonsillectomy, especially in pre-school aged children. However, this must be interpreted with caution as only three studies were performed in pre-school aged children. The decreased effectiveness in older children suggests possibly a threshold age when neurocognitive deficits become irreversible. Published by Elsevier Ireland Ltd.
C1 [Song, Sungjin A.; Tolisano, Anthony M.; Cable, Benjamin B.; Camacho, Macario] Tripler Army Med Ctr, Dept Otolaryngol Head & Neck Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
[Camacho, Macario] Stanford Hosp & Clin, Dept Psychiat & Behav Sci, Sleep Med Div, Stanford, CA USA.
RP Song, SA (reprint author), Tripler Army Med Ctr, Dept Otolaryngol Head & Neck Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM Sungjin.a.song.mil@mail.mil
NR 36
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Z9 1
U1 1
U2 1
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0165-5876
EI 1872-8464
J9 INT J PEDIATR OTORHI
JI Int. J. Pediatr. Otorhinolaryngol.
PD APR
PY 2016
VL 83
IS 4
BP 205
EP 210
DI 10.1016/j.ijporl.2016.02.011
PG 6
WC Otorhinolaryngology; Pediatrics
SC Otorhinolaryngology; Pediatrics
GA DH6ZX
UT WOS:000372941700037
PM 26968078
ER
PT J
AU Bastian, ND
Boguchwal, L
Langhans, Z
Evans, D
AF Bastian, Nathaniel D.
Boguchwal, Louis
Langhans, Zachary
Evans, Daniel
TI A multi-criteria, network analytic approach to war game participant
selection
SO JOURNAL OF DEFENSE MODELING AND SIMULATION-APPLICATIONS METHODOLOGY
TECHNOLOGY-JDMS
LA English
DT Article
DE Multiple criteria decision analysis; network analytics; team selection;
structural equivalence; war game
ID KNOWLEDGE ACQUISITION
AB A critical component of the military war game planning process is selecting who should participate, as these participants heavily influence war game outcomes. These outcomes directly impact both strategic and operational decision-making and defense planning, shaping both future defense policy and budget. In this paper, we propose a novel team selection algorithm and decision-support tool combining methods from multiple criteria decision analysis and network analytics to select and visualize a group of war game participants. This method accounts for the diverse requirements of the decision-maker. The results are not only applicable to war games, but also to any team selection domain, such as employee hiring and college admissions.
C1 [Bastian, Nathaniel D.] Penn State Univ, Dept Ind & Mfg Engn, University Pk, PA 16802 USA.
[Bastian, Nathaniel D.; Boguchwal, Louis; Langhans, Zachary; Evans, Daniel] US Mil Acad, Dept Math Sci, Network Sci Ctr, West Point, NY USA.
RP Bastian, ND (reprint author), Penn State Univ, 355 Leonhard Bldg, University Pk, PA 16802 USA.
EM ndbastian@psu.edu
NR 15
TC 0
Z9 0
U1 0
U2 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1548-5129
EI 1557-380X
J9 J DEF MODEL SIMUL-AP
JI J. Def. Model. Simul.-Appl. Methodol. Technol.-JDMS
PD APR
PY 2016
VL 13
IS 2
BP 183
EP 194
DI 10.1177/1548512915586883
PG 12
WC Engineering, Multidisciplinary
SC Engineering
GA DI3GP
UT WOS:000373387200005
ER
PT J
AU Reed, GS
Petty, MD
Jones, NJ
Morris, AW
Ballenger, JP
Delugach, HS
AF Reed, Gregory S.
Petty, Mikel D.
Jones, Nicholaos J.
Morris, Anthony W.
Ballenger, John P.
Delugach, Harry S.
TI A principles-based model of ethical considerations in military decision
making
SO JOURNAL OF DEFENSE MODELING AND SIMULATION-APPLICATIONS METHODOLOGY
TECHNOLOGY-JDMS
LA English
DT Article
DE Human behavior modeling; decision analysis; machine ethics; modeling and
simulation
ID LINEAR-MODELS; EVIL
AB When comparing alternative courses of action, modern military decision makers often must consider both the military effectiveness and the ethical consequences of the available alternatives. The basis, design, calibration, and performance of a principles-based computational model of ethical considerations in military decision making are reported in this article. The relative ethical violation (REV) model comparatively evaluates alternative military actions based upon the degree to which they violate contextually relevant ethical principles. It is based on a set of specific ethical principles deemed by philosophers and ethicists to be relevant to military courses of action. A survey of expert and non-expert human decision makers regarding the relative ethical violation of alternative actions for a set of specially designed calibration scenarios was conducted to collect data that was used to calibrate the REV model. Perhaps unsurprisingly, the survey showed that people, even experts, disagreed greatly amongst themselves regarding the scenarios' ethical considerations. Despite this disagreement, two significant results emerged. First, after calibration the REV model performed very well in terms of replicating the ethical assessments of human experts for the calibration scenarios. The REV model outperformed an earlier model that was based on tangible consequences rather than ethical principles, that earlier model performed comparably to human experts, the experts outperformed human non-experts, and the non-experts outperformed random selection of actions. All of these performance comparisons were measured quantitatively and confirmed with suitable statistical tests. Second, although humans tended to value some principles over others, none of the ethical principles involvedeven the principle of not harming civilianscompletely overshadowed all of the other principles.
C1 [Reed, Gregory S.; Petty, Mikel D.; Jones, Nicholaos J.; Ballenger, John P.; Delugach, Harry S.] Univ Alabama, Shelby Ctr 142,301 Sparkman Dr, Huntsville, AL 35899 USA.
[Morris, Anthony W.] Army Res Lab, AMCOM Field Element, Redstone Arsenal, AL USA.
RP Reed, GS (reprint author), Univ Alabama, Shelby Ctr 142,301 Sparkman Dr, Huntsville, AL 35899 USA.
EM gregory.reed@uah.edu
OI Jones, Nicholaos/0000-0003-4928-5089
NR 31
TC 0
Z9 0
U1 2
U2 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1548-5129
EI 1557-380X
J9 J DEF MODEL SIMUL-AP
JI J. Def. Model. Simul.-Appl. Methodol. Technol.-JDMS
PD APR
PY 2016
VL 13
IS 2
BP 195
EP 211
DI 10.1177/1548512915581213
PG 17
WC Engineering, Multidisciplinary
SC Engineering
GA DI3GP
UT WOS:000373387200006
ER
PT J
AU Cassenti, DN
AF Cassenti, Daniel N.
TI A robotics operator manager role for military application
SO JOURNAL OF DEFENSE MODELING AND SIMULATION-APPLICATIONS METHODOLOGY
TECHNOLOGY-JDMS
LA English
DT Article
DE Robotics; network science; cognitive modeling; decision making
AB Due to the increasing use of robots in US military operations, a new role may help to manage and coordinate multiple robotic assets, especially when considering the high mental workload requirements for robot control. The role of a robotics operator manager (ROM) was formed to study a path forward in solving this problem. An experiment with human test participants acting as ROMs showed that the ROM role as constructed is a workable solution to the robot management problems and also showed that time limits and bandwidth limitation affected engineered explosive detection performance, assessments of trust, and ratings of mental workload. Some of these results and others showing preferences for image stimuli and ground robots were simulated in an Adaptive Control of Thought-Rational model of the ROM experiment. The experimental and model results reveal that the ROM is not just a workable solution to the robot coordination problem, but that it may also be a preferred solution. I conclude with notes on how to field the role with personnel of specific skill sets.
C1 [Cassenti, Daniel N.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Cassenti, DN (reprint author), US Army, Res Lab, RDRL HRS E, Aberdeen Proving Ground, MD 21005 USA.
EM daniel.n.cassenti.civ@mail.mil
NR 19
TC 0
Z9 0
U1 3
U2 5
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1548-5129
EI 1557-380X
J9 J DEF MODEL SIMUL-AP
JI J. Def. Model. Simul.-Appl. Methodol. Technol.-JDMS
PD APR
PY 2016
VL 13
IS 2
BP 227
EP 237
DI 10.1177/1548512916630178
PG 11
WC Engineering, Multidisciplinary
SC Engineering
GA DI3GP
UT WOS:000373387200008
ER
PT J
AU Britt, TW
Crane, M
Hodson, SE
Adler, AB
AF Britt, Thomas W.
Crane, Monique
Hodson, Stephanie E.
Adler, Amy B.
TI Effective and Ineffective Coping Strategies in a Low-Autonomy Work
Environment
SO JOURNAL OF OCCUPATIONAL HEALTH PSYCHOLOGY
LA English
DT Article
DE stressors; coping; mental health; low job control; acceptance
ID COVARIANCE STRUCTURE-ANALYSIS; ADULT INTIMATE-RELATIONSHIPS;
MENTAL-HEALTH PROBLEMS; THEORETICAL PERSPECTIVE; JOB-SATISFACTION; TEST
STATISTICS; SELF-REPORT; STRESS; PERFORMANCE; SUPPORT
AB The authors examined the effectiveness of different coping strategies in buffering the negative effects of uncontrollable stressors and predicting mental health symptoms in a low-autonomy work environment using a longitudinal design. Soldiers in training indicated the extent to which they engaged in various coping strategies to deal with stressors related to the training environment at 4 different points in time. Factor analyses of soldiers in 2 different countries (i.e., United States and Australia) yielded 5 coping dimensions: active coping, acceptance of demands, seeking social support, humor, and denial/selfcriticism. Among U.S. soldiers in basic training, acceptance of demands and denial/self-criticism interacted with the magnitude of basic-training stressors to predict mental health symptoms (depression and anxiety) at 3 different points during training while controlling for symptoms at the immediate prior time period. Acceptance buffered soldiers from the negative effects of the stressors, whereas denial/self-criticism exacerbated the effects of the stressors. The results of LGC models also indicated that the slopes of acceptance and active coping were negatively related to the slope of mental health symptoms across training, whereas the slope for denial/self-criticism was positively related to the slope of symptoms. Active coping was less predictive of functioning in the face of stressors and in the prediction of symptoms over time. The results demonstrated that in a low-autonomy occupational setting, acceptance coping was more effective in facilitating good mental health outcomes compared with other coping strategies considered important in prior research (e.g., active coping).
C1 [Britt, Thomas W.] Clemson Univ, Dept Psychol, Clemson, SC 29634 USA.
[Crane, Monique] Macquarie Univ, Dept Psychol, N Ryde, NSW 2109, Australia.
[Hodson, Stephanie E.] Australian Dept Def, Directorate Operat & Strateg Mental Hlth, Canberra, ACT, Australia.
[Adler, Amy B.] Walter Reed Army Inst Res, US Army, Med Res Unit Europe, Heidelberg, Germany.
[Hodson, Stephanie E.] Dept Vet Affairs, Canberra, ACT, Australia.
RP Britt, TW (reprint author), Clemson Univ, Dept Psychol, Clemson, SC 29634 USA.
EM twbritt@clemson.edu
FU Research Triangle Institute (RTI)
FX We thank Michael Wood, Michael Rinehart, Michael Hagan, Tracy Johnson,
Victor Martinez, Rachel Eckford, Angela Salvi, Steven Terry, Julie
Merrill, Louis Csoka, Tom Powers, Sonya Cable, Stephanie Muraca, and the
Research Triangle Institute (RTI) for their research support in the
United States; and David Morton, Stephanie Hodson, and Andrew Cohn for
their research support in the Australian Defence Force. The views
expressed in this article are those of the authors and do not
necessarily represent the official policy or position of the U.S. Army
Medical Command or the Australian Defence Force.
NR 72
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U1 12
U2 20
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 1076-8998
EI 1939-1307
J9 J OCCUP HEALTH PSYCH
JI J. Occup. Health Psychol.
PD APR
PY 2016
VL 21
IS 2
BP 154
EP 168
DI 10.1037/a0039898
PG 15
WC Public, Environmental & Occupational Health; Psychology, Applied
SC Public, Environmental & Occupational Health; Psychology
GA DI0XM
UT WOS:000373220600003
PM 26641486
ER
PT J
AU Guevara, C
Pirgousis, P
Steinberg, B
AF Guevara, Carlo
Pirgousis, Phillip
Steinberg, Barry
TI Maxillofacial Gunshot Injuries: A Comparison of Civilian and Military
Data
SO JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
LA English
DT Article
ID WOUNDS; MANAGEMENT; FACE
AB Purpose: To compare military with civilian gunshot wounds (GSWs) in the maxillofacial region in order to establish differences in presentation, morbidity, and surgical management.
Materials and Methods: A cross-sectional study design was used. The University of Florida at Jacksonville oral and maxillofacial surgery operating room census and hospital trauma registry were both reviewed to identify maxillofacial GSW cases from 2005 through 2011. Military GSW data (2005 through 2011) were obtained from the US Department of Defense (DOD). The predictor variables were civilian versus military GSW events. The outcome variables of interest included the region of the face involved, race, gender, death during admission, hospital length of stay, and number of days in the intensive care unit (ICU). Descriptive statistics were computed.
Results: The sample was divided into military maxillofacial GSWs (n = 412) and civilian maxillofacial GSWs (n = 287 treated of 2,478 presented). A significant difference was measured between study groups regarding the region of the face involved (P = .0451), gender (P <= .0001), and race (P <= .0001). No significant relationship was measured regarding deaths during admission (P = .6510) for either study group. No standard deviation values for hospital length of stay or number of ICU days were provided by the DOD. The mean hospital length of stay for the military group was within the 95% confidence interval of the civilian group findings (6.0-7.6). The mean number of ICU days for the military group was not within the civilian group's 95% confidence interval (1.9-2.9).
Conclusions: These data showed important differences in anatomic location, gender, and race distribution of maxillofacial GSWs between military and civilian populations. Limited analysis of hospital length of stay and number of ICU days might indicate no meaningful difference in hospital length of stay, although there was a statistical difference in the number of ICU days between the 2 populations. Future research comparing surgical strategies in these 2 environments could assist maxillofacial surgeons in providing optimal care to their patients. (C) 2016 American Association of Oral and Maxillofacial Surgeons
C1 [Guevara, Carlo; Steinberg, Barry] Univ Florida Hosp, Dept Oral & Maxillofacial Surg, Jacksonville, FL USA.
[Pirgousis, Phillip] Univ Florida Hosp, Div Head & Neck Surg, Dept Oral & Maxillofacial Surg, Jacksonville, FL USA.
[Steinberg, Barry] US Army Reserve, Joint Special Operat Med Training Ctr, Jacksonville, FL USA.
RP Guevara, C (reprint author), 9745 Touchton Rd,Apartment 725, Jacksonville, FL 32246 USA.
EM carlo.guevara@jax.ufl.edu
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U2 2
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0278-2391
EI 1531-5053
J9 J ORAL MAXIL SURG
JI J. Oral Maxillofac. Surg.
PD APR
PY 2016
VL 74
IS 4
AR 795.e1
DI 10.1016/j.joms.2015.11.007
PG 7
WC Dentistry, Oral Surgery & Medicine
SC Dentistry, Oral Surgery & Medicine
GA DH9BI
UT WOS:000373090400019
PM 26687155
ER
PT J
AU Wong, MR
Reggio, MJ
Morocho, FR
Holloway, MM
Garcia-Blanco, JC
Jenkins, C
Johnson, AD
AF Wong, Marc R.
Reggio, Matt J.
Morocho, Freddy R.
Holloway, Monica M.
Garcia-Blanco, Jose C.
Jenkins, Constance
Johnson, Arthur D.
TI Effects of intraosseous epinephrine in a cardiac arrest swine model
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE Epinephrine; Intraosseous; Intravenous; Pharmacokinetics;
Cardiopulmonary resuscitation; Return of spontaneous circulation
ID AMERICAN-HEART-ASSOCIATION; EMERGENCY CARDIOVASCULAR CARE; RANDOMIZED
CONTROLLED-TRIAL; CARDIOPULMONARY-RESUSCITATION;
VENTRICULAR-FIBRILLATION; CHEST COMPRESSIONS; PERFUSION-PRESSURE;
VASCULAR ACCESS; GUIDELINES
AB Background: Interruptions in cardiopulmonary resuscitation (CPR) to obtain vascular access reduces blood flow to vital organs. Tibial intraosseous (TIO) access may be a faster alternative to intravenous (IV) access for delivery of vasoactive medications. The purpose of this study was to examine the differences in pharmacokinetics and pharmacodynamics of TIO- and IV-delivered epinephrine.
Materials and methods: A prospective, between subjects, experimental design comparing C-max, T-max, return of spontaneous circulation (ROSC), and time to ROSC. Adult male swine were divided into three equal groups (n = 7) all received CPR and defibrillation: the second group received IV epinephrine and the third group received tibial intraosseous epinephrine. Swine were placed in cardiac arrest for 2 min before CPR was initiated. After 2 min of CPR, epinephrine was delivered by IV or TIO, and serial blood samples were collected over 4 min.
Results: There were no significant differences between IV versus TIO epinephrine in achieving ROSC, time to ROSC, and C-max. A one-way analysis of variance demonstrated a significant difference between the IV and TIO groups in T-max (P = 0.025). A Fisher exact test demonstrated a significant difference between IV epinephrine versus CPR/Defib only (P = 0.035) and TIO epinephrine versus CPR/Defib only (P = 0.010) in achieving ROSC. A multivariate analysis of variance showed significant differences in IV versus intraosseous epinephrine concentration at specific time intervals: 60 (P = 0.023), 90 (P = 0.001), and 120 (P < 0.000) sec.
Conclusions: In the context of ROSC, epinephrine delivered via TIO route is a clinically relevant alternative to IV administration. When IV access cannot be immediately obtained in cardiac arrest patients, TIO access should be considered. Published by Elsevier Inc.
C1 [Wong, Marc R.; Reggio, Matt J.; Morocho, Freddy R.; Holloway, Monica M.; Jenkins, Constance; Johnson, Arthur D.] US Army Med Dept Ctr & Sch, Hlth Readiness Ctr Excellence, Grad Sch US Army Grad Program Nursing Anesthesia, JBSA FSH, San Antonio, TX USA.
[Garcia-Blanco, Jose C.] Texas Tech Univ, Hlth Sci Ctr El Paso, Dept Internal Med, El Paso, TX USA.
RP Johnson, AD (reprint author), US Army Grad Program Nursing Anesthesia, JBSA FSH, Dunlap Hall,BLDG 1394,Rm 118, Ft Sam Houston, TX 78234 USA.
EM arthurjohnso@gmail.com
FU TriService Nursing Research Program, Bethesda, MD [HU0001-11-1-TS08]
FX Research funding for this study (grant number: HU0001-11-1-TS08) was
provided by TriService Nursing Research Program, Bethesda, MD. The
opinions expressed are those of the authors and are not necessarily
representative of those of the US Army Graduate Program in Anesthesia
Nursing, the United States Army, or the Department of Defense. The
authors have no proprietary or commercial interest in any product
mentioned in the article.
NR 29
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PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD APR
PY 2016
VL 201
IS 2
BP 327
EP 333
DI 10.1016/j.jss.2015.11.015
PG 7
WC Surgery
SC Surgery
GA DH8VS
UT WOS:000373075600013
PM 27020815
ER
PT J
AU Torres, I
Nguyen, NM
Jivani, R
Terner, J
Romfh, P
Vakhshoori, D
Ward, KR
AF Torres Filho, Ivo
Nguyen, Nguyen M.
Jivani, Rizwan
Terner, James
Romfh, Padraic
Vakhshoori, Daryoosh
Ward, Kevin R.
TI Oxygen saturation monitoring using resonance Raman spectroscopy
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE Oxygen saturation; Raman spectroscopy; Shock; Hemorrhage; Tissue
oxygenation
ID NEAR-INFRARED SPECTROSCOPY; OPTICAL-PATH LENGTH; TISSUE OXYGENATION;
HEMORRHAGIC-SHOCK; MICROCIRCULATION; HEMOGLOBIN; HYPOXIA; IMAGES; VEIN
AB Background: The knowledge of hemoglobin oxygen saturation (SO2) and tissue oxygenation is critical to identify the presence of shock and therapeutic options. The resonance vibrational enhancement of hemoglobin allows measurement of oxy- and deoxy species of hemoglobin and resonance Raman spectroscopy (RRS-StO(2)) has been successfully used to measure aggregate microvascular oxygenation. We tested the hypothesis that noninvasive oxygen saturation measured by RRS-StO(2) could serve as surrogate of systemic central venous SO2.
Methods: In anesthetized rats, measurements of RRS-StO(2) made in oral mucosa, skin, muscle, and liver were compared with measurements of central venous SO2 using traditional multi-wavelength oximetry. Various oxygenation levels were obtained using a stepwise hemorrhage while over 100 paired blood samples and Raman-based measurements were performed. The relationships between RRS-StO(2) and clinically important systemic blood parameters were also evaluated. RRS-StO(2) measurements were made in 3-mm diameter tissue areas using a microvascular oximeter and a handheld probe.
Results: Significant correlations were found between venous SO2 and RRS-StO(2) measurements made in the oral mucosa (r = 0.913, P < 0.001), skin (r = 0.499, P < 0.01), and liver (r = 0.611, P < 0.05). The mean difference between sublingual RRS-StO(2) and blood sample SO2 values was 5.4 +/- 1.6%. Sublingual RRS-StO(2) also correlated with lactate (r = 0.909, P < 0.01), potassium (r = 0.757, P < 0.01), and pH (r = 0.703, P < 0.05).
Conclusions: Raman-based oxygen saturation is a promising technique for the noninvasive evaluation of oxygenation in skin, thin tissues, and solid organs. Under certain conditions, sublingual RRS-StO(2) measurements correlate with central venous SO2. Published by Elsevier Inc.
C1 [Torres Filho, Ivo; Nguyen, Nguyen M.; Jivani, Rizwan] Virginia Commonwealth Univ, Dept Anesthesiol, Richmond, VA USA.
[Torres Filho, Ivo; Nguyen, Nguyen M.; Jivani, Rizwan; Terner, James] Virginia Commonwealth Univ, Reanimat Engn Sci Ctr, Richmond, VA USA.
[Torres Filho, Ivo] Virginia Commonwealth Univ, Dept Emergency Med, Richmond, VA USA.
[Torres Filho, Ivo] US Army Inst Surg Res, Damage Control Resuscitat, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.
[Terner, James] Virginia Commonwealth Univ, Dept Chem, Box 2006, Richmond, VA 23284 USA.
[Romfh, Padraic; Vakhshoori, Daryoosh] Pendar Med, Cambridge, MA USA.
[Ward, Kevin R.] Univ Michigan, Dept Emergency Med, Ann Arbor, MI 48109 USA.
[Ward, Kevin R.] Univ Michigan, Michigan Ctr Integrat Res Crit Care, Ann Arbor, MI 48109 USA.
RP Torres, I (reprint author), US Army Inst Surg Res, Damage Control Resuscitat, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.
EM ivo.p.torresfilho.civ@mail.mil
NR 29
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U1 4
U2 8
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD APR
PY 2016
VL 201
IS 2
BP 425
EP 431
DI 10.1016/j.jss.2015.12.001
PG 7
WC Surgery
SC Surgery
GA DH8VS
UT WOS:000373075600026
ER
PT J
AU Robinson, JD
Vahedifard, F
Rais-Rohani, M
Mason, GL
Priddy, JD
AF Robinson, Joe D.
Vahedifard, Farshid
Rais-Rohani, Masoud
Mason, George L.
Priddy, Jody D.
TI Multi-objective traction optimization of vehicles in loose dry sand
using the generalized reduced gradient method
SO JOURNAL OF TERRAMECHANICS
LA English
DT Article
DE Mobility; Vehicle terrain interface (VTI) model; Drawbar pull (DBP)
coefficient; Work optimum coefficient (WOC); Multi-objective
optimization
ID TRACKED VEHICLE
AB A work optimization strategy is combined with algorithms within the vehicle-terrain interface (VTI) model to maximize the traction of a four-wheel vehicle operating on loose dry sand. The optimization model distributes traction among the steered and non-steered wheels with the work optimum coefficient (WOC) of each wheel treated as an independent design objective. Drawbar pull (DBP), motion resistance (MR), longitudinal traction coefficient (LTC), lateral force coefficient (LFC), tire deflection, and wheel slip are key parameters that appear in the VTI model for traction performance analysis. The analysis includes wheels of different diameters, widths, heights, and inflation pressures, under variable wheel slips. A multi-objective optimization problem is formulated over a thirteen-dimensional search space bounded by eight design constraints. The generalized reduced gradient method is used to predict optimal values of the design variables as well as ground and traction parameters such as DBP, MR, LTC, and LFC for maximum slope climbing efficiency. The WOCs are maximized for lateral slip angles between 0 degrees and 24 degrees to find a set of Pareto optimal solutions over a wide range of weight factors. A method to apply the optimization results for predicting vehicle performance and traction control on dry sand is presented and discussed. (C) 2016 ISTVS. Published by Elsevier Ltd. All rights reserved.
C1 [Robinson, Joe D.; Vahedifard, Farshid] Mississippi State Univ, Dept Civil & Environm Engn, Mississippi State, MS 39762 USA.
[Robinson, Joe D.; Vahedifard, Farshid; Rais-Rohani, Masoud; Mason, George L.] Mississippi State Univ, Ctr Adv Vehicular Syst, Mississippi State, MS 39762 USA.
[Rais-Rohani, Masoud] Mississippi State Univ, Dept Aerosp Engn, Mississippi State, MS 39762 USA.
[Priddy, Jody D.] US Army, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
RP Vahedifard, F (reprint author), Mississippi State Univ, Dept Civil & Environm Engn, Mississippi State, MS 39762 USA.; Vahedifard, F (reprint author), Mississippi State Univ, Ctr Adv Vehicular Syst, Mississippi State, MS 39762 USA.
EM jdr418@msstate.edu; farshid@cee.msstate.edu; masoud@ae.msstate.edu;
George.1.Mason.PE@engineer.com; Jody.D.Priddy@erdc.dren.mil
FU U.S. Government [W15QKN-13-9-0001]
FX This paper is based upon work sponsored by the U.S. Government under
Other Transaction number W15QKN-13-9-0001 between the Consortium for
Energy, Environment and Demilitarization, and the Government. The U.S.
Government is authorized to reproduce and distribute reprints for
Governmental purposes notwithstanding any copyright notation thereon.
The views and conclusions contained herein are those of the authors and
should not be interpreted as necessarily representing the official
policies or endorsements, either expressed or implied, of the U.S.
Government. This paper is based on the work conducted under Task 12:
Mobility Modeling for Soils. Roger King, Director of the Center for
Advanced Vehicular Systems (CAVS) at Mississippi State University, was
principal investigator for W15QKN-13-9-0001 and Farshid Vahedifard was
the lead for Task 12.
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U2 9
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-4898
EI 1879-1204
J9 J TERRAMECHANICS
JI J. Terramech.
PD APR
PY 2016
VL 64
BP 46
EP 57
DI 10.1016/j.jterra.2015.12.005
PG 12
WC Engineering, Environmental
SC Engineering
GA DH3IM
UT WOS:000372680700005
ER
PT J
AU Karl, JP
Smith, TJ
Wilson, MA
Bukhari, AS
Pasiakos, SM
McClung, HL
McClung, JP
Lieberman, HR
AF Karl, J. Philip
Smith, Tracey J.
Wilson, Marques A.
Bukhari, Asma S.
Pasiakos, Stefan M.
McClung, Holly L.
McClung, James P.
Lieberman, Harris R.
TI Altered metabolic homeostasis is associated with appetite regulation
during and following 48-h of severe energy deprivation in adults
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE Energy density; Satiety; Substrate oxidation; Weight loss; Starvation
ID DEHYDROEPIANDROSTERONE-SULFATE LEVELS; OBESE ZUCKER RATS; FOOD-INTAKE;
PHYSICAL PERFORMANCE; BODY-COMPOSITION; HYPOTHALAMIC NEUROTRANSMITTERS;
CARDIOVASCULAR-DISEASE; CONTROLLED-TRIAL; WEIGHT-LOSS; DHEA-S
AB Background. Military personnel frequently endure intermittent periods of severe energy deficit which can compromise health and performance. Physiologic factors contributing to underconsumption, and the subsequent drive to overeat, are not fully characterized. This study aimed to identify associations between appetite, metabolic homeostasis and endocrine responses during and following severe, short-term energy deprivation.
Methods. Twenty-three young adults (17 M/6 F, 21 +/- 3 years, BMI 25 +/- 3 kg/m(2)) participated in a randomized, controlled, crossover trial. During separate 48-h periods, participants increased habitual energy expenditure by 1647 +/- 345 kcal/d (mean +/- SD) through prescribed exercise at 40-65% VO2peak, and consumed provided isovolumetric diets designed to maintain energy balance at the elevated energy expenditure (EB; 36 +/- 93 kcal/d energy deficit) or to produce a severe energy deficit (ED; 3681 +/- 716 kcal/d energy deficit). Appetite, markers of metabolic homeostasis and endocrine mediators of appetite and substrate availability were periodically measured. Ad libitum energy intake was measured over 36 h following both experimental periods.
Results. Appetite increased during ED and was greater than during EB despite maintenance of diet volume (P = 0.004). Ad libitum energy intake was 907 kcal/36 h [95% CI: 321, 1493 kcal/36 h, P = 0.004] higher following ED compared to following EB. Serum beta-hydroxybutyrate, free fatty acids, branched-chain amino acids, dehydroepiandrosterone-sulfate (DHEA-S) and cortisol concentrations were higher (P < 0.001 for all), whereas whole-body protein balance was more negative (P < 0.001), and serum glucose, insulin, and leptin concentrations were lower (P < 0.001 for all) during ED relative to during EB. Cortisol concentrations, but not any other hormone or metabolic substrate, were inversely associated with satiety during EB (R-2 = 0.23, P = 0.04). In contrast, serum glucose and DHEA-S concentrations were inversely associated with satiety during ED (R-2 = 0.68, P < 0.001). No associations between physiologic variables measured during EB and ad libitum energy intake following EB were observed. However, serum leptin and net protein balance measured during ED were inversely associated with ad libitum energy intake following ED (R-2 = 0.48, P = 0.01).
Conclusion. These findings suggest that changes in metabolic homeostasis during energy deprivation modulate appetite independent of reductions in diet volume. Following energy deprivation, physiologic signals of adipose and lean tissue loss may drive restoration of energy balance. Clinical trials registration: www.clinicaltrials.gov #NCT01603550. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Karl, J. Philip; Smith, Tracey J.; Wilson, Marques A.; Bukhari, Asma S.; Pasiakos, Stefan M.; McClung, Holly L.; McClung, James P.; Lieberman, Harris R.] US Army Res Inst Environm Med, Mil Nutr Div, 10 Gen Greene Ave,Bldg 42, Natick, MA 01760 USA.
RP Karl, JP (reprint author), US Army Res Inst Environm Med, 10 Gen Greene Ave,Bldg 42, Natick, MA 01760 USA.
EM james.p.karl.civ@mail.mil
RI Pasiakos, Stefan/E-6295-2014
OI Pasiakos, Stefan/0000-0002-5378-5820
FU US Army Medical Research and Materiel Command
FX This study is funded by US Army Medical Research and Materiel Command.
The study sponsor had no role in the study design, in data collection,
analysis or interpretation, in writing the report, or in the decision to
submit the report for publication.
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PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD APR
PY 2016
VL 65
IS 4
BP 416
EP 427
DI 10.1016/j.metabol.2015.11.001
PG 12
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA DH3EU
UT WOS:000372671100004
PM 26975533
ER
PT J
AU Tenan, MS
Hackney, AC
Griffin, L
AF Tenan, Matthew S.
Hackney, Anthony C.
Griffin, Lisa
TI ENTRAINMENT OF VASTUS MEDIALIS COMPLEX ACTIVITY DIFFERS BETWEEN GENDERS
SO MUSCLE & NERVE
LA English
DT Article
DE gender differences; knee; menstrual cycle; motor unit; quadriceps;
vastus medialis oblique
ID PATELLOFEMORAL PAIN SYNDROME; MOTOR UNIT DISCHARGES; OBLIQUE MUSCLE;
PHYSIOLOGICAL TREMOR; QUADRICEPS MUSCLES; MENSTRUAL-CYCLE;
SYNCHRONIZATION; MODULATION; INCREASES; MECHANISM
AB Introduction: That the vastus medialis oblique (VMO) is a functional unit of the vastus medialis (VM) is disputed. Delayed VMO activation predicts patellofemoral pain, which has higher rates in women. Methods: Single MUs and surface electromyogram (EMG) were collected from the VMO and VM of 9 men and 9 women. Men were tested once; women were tested during 5 menstrual phases. Coherence was assessed for motor unit (MU) firings within and between the VM and VMO using multilevel logistic models to determine statistical significance. Results: Compared with women, men have 741% (MU pairs) and 256% (MU-EMG pairs) greater odds of common drive (0-5 HZ) coherent oscillations. MU pairs from the VMO and the dual VM/VMO complex have 228% and 212% greater odds of coherent oscillations in the beta band (15-35 HZ) compared with VM pairs. Conclusions: The VM and VMO are neurologically different muscles; control of the VM complex is sexually dimorphic.
C1 [Tenan, Matthew S.; Griffin, Lisa] Univ Texas Austin, Dept Kinesiol & Hlth Educ, Austin, TX 78712 USA.
[Tenan, Matthew S.] US Army, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD USA.
[Hackney, Anthony C.] Univ N Carolina, Sch Publ Hlth, Dept Nutr, Dept Exercise & Sport Sci, Chapel Hill, NC 21005 USA.
RP Tenan, MS (reprint author), Univ Texas Austin, Dept Kinesiol & Hlth Educ, Austin, TX 78712 USA.; Tenan, MS (reprint author), US Army, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD USA.
EM matthew.s.tenan.civ@mail.mil
NR 35
TC 0
Z9 0
U1 2
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0148-639X
EI 1097-4598
J9 MUSCLE NERVE
JI Muscle Nerve
PD APR
PY 2016
VL 53
IS 4
BP 633
EP 640
DI 10.1002/mus.24897
PG 8
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA DI2SG
UT WOS:000373348300020
PM 26348648
ER
PT J
AU Soonwera, M
Phasomkusolsil, S
AF Soonwera, Mayura
Phasomkusolsil, Siriporn
TI Effect of Cymbopogon citratus (lemongrass) and Syzygium aromaticum
(clove) oils on the morphology and mortality of Aedes aegypti and
Anopheles dirus larvae
SO PARASITOLOGY RESEARCH
LA English
DT Article
DE Aedes aegypti; Anopheles dirus; Cymbopogon citratus; Syzygium
aromaticum; Larvicide; Morphological aberrations
ID CULEX-QUINQUEFASCIATUS SAY; CHEMICAL-COMPOSITION; MOSQUITO LARVAE;
OVIPOSITION-DETERRENT; LARVICIDAL ACTIVITY; PLANT-EXTRACTS; CULICIDAE;
DIPTERA; REPELLENCY; THAILAND
AB Cymbopogon citratus (lemongrass) and Syzygium aromaticum (clove) oils were evaluated to determine mortality rates, morphological aberrations, and persistence when used against third and fourth larval instars of Aedes aegypti and Anopheles dirus. The oils were evaluated at 1, 5, and 10 % concentrations in mixtures with soybean oil. Persistence of higher concentrations was measured over a period of 10 days. For Ae. aegypti, both plant oils caused various morphological aberrations to include deformed larvae, incomplete eclosion, white pupae, deformed pupae, dead normal pupae, and incomplete pupal eclosion. All of these aberrations led to larval mortality. In Ae. aegypti larvae, there were no significant differences in mortality at days 1, 5, and 10 or between third and fourth larval instar exposure. In An. dirus, morphological aberrations were rare and S. aromaticum oil was more effective in causing mortality among all larval stages. Both oils were equally effective at producing mortality on days 1, 5, and 10. Both oils had slightly increased LT50 rates from day 1 to day 10. In conclusion, both lemongrass and clove oils have significant effects on the immature stages of Ae. aegypti and An. dirus and could potentially be developed for use as larvicides.
C1 [Soonwera, Mayura] King Mongkuts Inst Technol Ladkrabang, Deparment Plant Prod Technol, Fac Agr Technol, Bangkok 10520, Thailand.
[Phasomkusolsil, Siriporn] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand.
RP Phasomkusolsil, S (reprint author), Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand.
EM siripornp@afrims.org
NR 41
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U1 4
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0932-0113
EI 1432-1955
J9 PARASITOL RES
JI Parasitol. Res.
PD APR
PY 2016
VL 115
IS 4
BP 1691
EP 1703
DI 10.1007/s00436-016-4910-z
PG 13
WC Parasitology
SC Parasitology
GA DH6NL
UT WOS:000372907300036
PM 26796022
ER
PT J
AU Solmeyer, N
Li, X
Quraishi, Q
AF Solmeyer, Neal
Li, Xiao
Quraishi, Qudsia
TI High teleportation rates using cold-atom-ensemble-based quantum
repeaters with Rydberg blockade
SO PHYSICAL REVIEW A
LA English
DT Article
ID SINGLE PHOTONS; LINEAR OPTICS; MEMORY; COMMUNICATION; STATE; QUBITS;
PAIRS
AB We present a simplified version of a repeater protocol in a cold neutral-atom ensemble with Rydberg excitations optimized for two-node entanglement generation and describe a protocol for quantum teleportation. Our proposal draws from previous proposals [B. Zhao et al., Phys. Rev. A 81, 052329 (2010); Y. Han et al., ibid. 81, 052311 (2010)] that described efficient and robust protocols for long-distance entanglement with many nodes. Using realistic experimental values, we predict an entanglement generation rate of similar to 25 Hz and a teleportation rate of similar to 5Hz. Our predicted rates match the current state-of-the-art experiments for entanglement generation and teleportation between quantum memories. With improved efficiencies we predict entanglement generation and teleportation rates of similar to 7.8 and similar to 3.6 kHz, respectively, representing a two-order-of-magnitude improvement over the currently realized values. Cold-atom ensembles with Rydberg excitations are promising candidates for repeater nodes because collective effects in the ensemble can be used to deterministically generate a long-lived ground-state memory which may be efficiently mapped onto a directionally emitted single photon.
C1 [Solmeyer, Neal; Quraishi, Qudsia] Army Res Lab, Quantum Sci Grp, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
[Li, Xiao] Univ Maryland, Joint Quantum Inst, College Pk, MD 20742 USA.
[Li, Xiao] Univ Maryland, Dept Phys, College Pk, MD 20742 USA.
RP Solmeyer, N (reprint author), Army Res Lab, Quantum Sci Grp, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
FU Oak Ridge Associated Universities (ORAU) postdoctoral fellowship; Army
Research Laboratory [W911NF-14-2-0101]
FX We would like to thank S. Rolston and A. Gorshkov for helpful
discussions. N.S. acknolwedges support through an Oak Ridge Associated
Universities (ORAU) postdoctoral fellowship. This research was supported
by the Army Research Laboratory under Contract #W911NF-14-2-0101. The
views and conclusions contained in this document are those of the
authors and should not be interpreted as representing the official
policies, either expressed or implied, of the Army Research Laboratory
or the U.S. Government. The U.S. Government is authorized to reproduce
and distribute reprints for Government purposes notwithstanding any
copyright notation herein.
NR 60
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Z9 0
U1 7
U2 12
PU AMER PHYSICAL SOC
PI COLLEGE PK
PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA
SN 2469-9926
EI 2469-9934
J9 PHYS REV A
JI Phys. Rev. A
PD APR 1
PY 2016
VL 93
IS 4
AR 042301
DI 10.1103/PhysRevA.93.042301
PG 14
WC Optics; Physics, Atomic, Molecular & Chemical
SC Optics; Physics
GA DI0SC
UT WOS:000373206300003
ER
PT J
AU Busby, RR
Rodriguez, G
Gebhart, DL
Yannarell, AC
AF Busby, Ryan R.
Rodriguez, Giselle
Gebhart, Dick L.
Yannarell, Anthony C.
TI Native Lespedeza species harbor greater non-rhizobial bacterial
diversity in root nodules compared to the coexisting invader, L-cuneata
SO PLANT AND SOIL
LA English
DT Article
DE Lespedeza; Nodule bacteria; Legume; Plant invasion; Microbial diversity
ID EXOTIC PLANT INVASION; ENDOPHYTIC BACTERIA; SOIL BIOTA; GASTROINTESTINAL
NEMATODES; SERICEA-LESPEDEZA; BACILLUS STRAINS; NORTH-AMERICA; LEGUME;
GROWTH; MUTUALISMS
AB Background and Aims Lespedeza cuneata is a non-native invasive legume that alters the soil bacterial community, associates promiscuously with rhizobia, and benefits more from rhizobial interactions compared to coexisting native Lespedeza in North America. We tested the hypothesis that native congeners differ in their nodule bacteria associations compared to L. cuneata.
Methods Plots with high L. cuneata invasion, low L. cuneata invasion with native Lespedeza species present, and uninvaded plots where native Lespedeza species existed without L. cuneata were sampled. Nodules were collected from all Lespedeza species present, and Chamaecrista fasciculata, a common native annual legume. Bacterial DNA from nodules was isolated and sequenced.
Results Nodule bacterial composition differed significantly between hosts. L. cuneata nodules contained high frequencies of rhizobial DNA and low bacterial diversity, while native Lespedeza nodules contained lower rhizobial frequencies and higher non-rhizobial bacterial diversity. Specific non-rhizobial bacterial groups exhibited strong associations with native legumes and uninvaded sites.
Conclusions Significant differences exist in the nodule bacterial composition between native legumes and an introduced congener. The mechanism(s) and ecological importance of these differences remain unknown. These differences in bacterial associations could influence not only the competitive ability of the invader, but recovery of invaded sites as well.
C1 [Busby, Ryan R.; Rodriguez, Giselle; Gebhart, Dick L.] US Army, Engn Res & Dev Ctr, 2902 Newmark Dr, Champaign, IL 61822 USA.
[Yannarell, Anthony C.] Univ Illinois, Dept Nat Resources & Environm Sci, 1102 S Goodwin Ave, Urbana, IL 61801 USA.
RP Busby, RR (reprint author), US Army, Engn Res & Dev Ctr, 2902 Newmark Dr, Champaign, IL 61822 USA.
EM ryan.r.busby@usace.army.mil
FU United States Army Direct Funded Research Program [A896]
FX This research was funded by the United States Army A896 Direct Funded
Research Program.
NR 54
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Z9 0
U1 9
U2 17
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0032-079X
EI 1573-5036
J9 PLANT SOIL
JI Plant Soil
PD APR
PY 2016
VL 401
IS 1-2
BP 427
EP 436
DI 10.1007/s11104-015-2763-3
PG 10
WC Agronomy; Plant Sciences; Soil Science
SC Agriculture; Plant Sciences
GA DH7CC
UT WOS:000372947800030
ER
PT J
AU Simmons, M
Sun, PF
Putnak, R
AF Simmons, Monika
Sun, Peifang
Putnak, Robert
TI Recombinant Dengue 2 Virus NS3 Helicase Protein Enhances Antibody and
T-Cell Response of Purified Inactivated Vaccine
SO PLOS ONE
LA English
DT Article
ID WEST-NILE-VIRUS; IMMUNOLOGICAL-PROPERTIES; NONSTRUCTURAL PROTEINS;
STRUCTURAL PROTEINS; HEMORRHAGIC-FEVER; RHESUS MACAQUES; MICE;
ENCEPHALITIS; PROTECTION; IMMUNIZATION
AB Dengue virus purified inactivated vaccines (PIV) are highly immunogenic and protective over the short term, but may be poor at inducing cell-mediated immune responses and long-term protection. The dengue nonstructural protein 3 (NS3) is considered the main target for T-cell responses during viral infection. The amino (N)-terminal protease and the carboxy (C)-terminal helicase domains of DENV-2 NS3 were expressed in E.coli and analyzed for their immune-potentiating capacity. Mice were immunized with DENV-2 PIV with and without recombinant NS3 protease or NS3 helicase proteins, and NS3 proteins alone on days 0, 14 and 28. The NS3 helicase but not the NS3 protease was effective in inducing T-cell responses quantified by IFN-gamma ELISPOT. In addition, markedly increased total IgG antibody titer against virus antigen was seen in mice immunized with the PIV/NS3 helicase combination in the ELISA, as well as increased neutralizing antibody titer measured by the plaque reduction neutralization test. These results indicate the potential immunogenic properties of the NS3 helicase protein and its use in a dengue vaccine formulation.
C1 [Simmons, Monika; Sun, Peifang] Naval Med Res Ctr, Viral & Rickettsial Dis Dept, Silver Spring, MD USA.
[Putnak, Robert] Walter Reed Army Inst Res, Div Viral Dis, Silver Spring, MD USA.
RP Simmons, M (reprint author), Naval Med Res Ctr, Viral & Rickettsial Dis Dept, Silver Spring, MD USA.
EM monika.simmons.civ@mail.mil
FU Military Infectious Disease Research Program (MIDRP), U.S. Army Medical
Research and Materiel Command, Fort Detrick, MD [A1325]
FX This work was funded by a grant from the Military Infectious Disease
Research Program (MIDRP), U.S. Army Medical Research and Materiel
Command, Fort Detrick, MD, work unit number A1325. The funders had no
role in study design, data collection and analysis, decision to publish,
or preparation of the manuscript.
NR 48
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U1 1
U2 4
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 1
PY 2016
VL 11
IS 4
AR e0152811
DI 10.1371/journal.pone.0152811
PG 16
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DI0QF
UT WOS:000373201200044
PM 27035715
ER
PT J
AU Spain, E
Groysberg, B
AF Spain, Everett
Groysberg, Boris
TI MAKING EXIT INTERVIEWS COUNT
SO HARVARD BUSINESS REVIEW
LA English
DT Article
C1 [Spain, Everett] US Mil Acad, Dept Behav Sci & Leadership, W Point, WA 10996 USA.
[Groysberg, Boris] Harvard Univ, Sch Business, Business Adm, Cambridge, MA 02138 USA.
RP Spain, E (reprint author), US Mil Acad, Dept Behav Sci & Leadership, W Point, WA 10996 USA.
NR 0
TC 0
Z9 0
U1 1
U2 5
PU HARVARD BUSINESS SCHOOL PUBLISHING CORPORATION
PI WATERTOWN
PA 300 NORTH BEACON STREET, WATERTOWN, MA 02472 USA
SN 0017-8012
J9 HARVARD BUS REV
JI Harv. Bus. Rev.
PD APR
PY 2016
VL 94
IS 4
BP 88
EP 95
PG 8
WC Business; Management
SC Business & Economics
GA DH5VH
UT WOS:000372859900013
ER
PT J
AU Black, SR
Howard, JT
Chin, PC
Starr, AJ
AF Black, Sheena R.
Howard, Jeffrey T.
Chin, Paul C.
Starr, Adam J.
TI Toward a More Robust Prediction of Pulmonary Embolism in Trauma
Patients: A Risk Assessment Model Based on 38,000 Patients
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE deep venous thrombosis; pulmonary embolism; trauma; venous
thromboembolism
ID MOLECULAR-WEIGHT HEPARIN; DEEP VENOUS THROMBOSIS; VENA-CAVA FILTERS;
MEDICAL PATIENTS; MAJOR TRAUMA; THROMBOEMBOLISM PROPHYLAXIS; 1602
EPISODES; DATA-BANK; INJURY; PREVENTION
AB Objectives:
Pulmonary embolism (PE) is a rare but sometimes fatal complication of trauma. Risk stratification models identify patients at increased risk of PE; however, they are often complex and difficult to use. This research aims to develop a model, based on a large sample of trauma patients, which can be easily and quickly used at the time of admission to predict PE.
Methods:
This study used trauma registry data from 38,597 trauma patients. Of these, 239 (0.619%) developed a PE. We targeted demographic and injury data, prehospital information, and data on treatments and events during hospitalization. A multivariate binary logistic regression model was developed to predict the odds of developing a PE during hospitalization. The model was developed using a 50% randomly selected development subsample and then tested for accuracy using the remaining 50% validation sample.
Results:
We found 7 statistically significant predictors of PE, including (1) age [odds ratio (OR) = 1.01; 95% CI, 1.00-1.02; P = 0.05], (2) obesity (OR = 2.54; 95% CI, 1.29-4.99; P < 0.01), (3) injury from motorcycle accident (OR = 2.01; 95% CI, 1.25-3.22; P < 0.01), (4) arrival by helicopter (OR = 2.91; 95% CI, 1.16-7.27; P = 0.02), (5) emergency department admission pulse rate (OR = 1.01; 95% CI, 1.0-1.02; P = 0.06), (6) admission to intensive care unit (OR = 5.03; 95% CI, 3.12-8.12; P < 0.01), and (7) injury location, including thorax (OR = 1.57; 95% CI, 1.04-2.37; P = 0.03), abdomen (OR = 1.56; 95% CI, 1.04-2.33; P = 0.03), and lower extremity injuries (OR = 2.85; 95% CI, 3.12-8.12; P < 0.01). Our model was able to discriminate between predicted and actual PE events with a receiver operating characteristic area under the curve of 0.87. By identifying the top 25% high-risk patients, we were able to predict 80%-84% of pulmonary emboli.
Conclusions:
This knowledge allows us to focus stronger thromboprophylactic efforts on patients at highest risk. This model can be used to rapidly identify trauma patients at high risk for PE.
Level of Evidence:
Prognostic Level II. See Instructions for Authors for a complete description of levels of evidence.
C1 [Black, Sheena R.; Chin, Paul C.; Starr, Adam J.] Univ Texas SW Med Ctr Dallas, Dept Orthopaed Surg, 5323 Harry Hines Blvd, Dallas, TX 75390 USA.
[Howard, Jeffrey T.] US Army Inst Surg Res, Epidemiol & Biostat, San Antonio, TX USA.
RP Black, SR (reprint author), Univ Texas SW Med Ctr Dallas, Dept Orthopaed Surg, 5323 Harry Hines Blvd, Dallas, TX 75390 USA.
EM sheena.r.black@gmail.com
FU Starrframe, LLC; Smith & Nephew Surgical Approaches for Internal
Fixation (SAIF) course
FX A. J. Starr receives royalty payments from Starrframe, LLC and is a paid
speaker for the Smith & Nephew Surgical Approaches for Internal Fixation
(SAIF) course. The remaining authors report no conflict of interest.
NR 52
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U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD APR
PY 2016
VL 30
IS 4
BP 200
EP 207
DI 10.1097/BOT.0000000000000484
PG 8
WC Orthopedics; Sport Sciences
SC Orthopedics; Sport Sciences
GA DG8QG
UT WOS:000372348100010
PM 26562582
ER
PT J
AU Fink, DS
Gallaway, MS
Tamburrino, MB
Liberzon, I
Chan, P
Cohen, GH
Sampson, L
Shirley, E
Goto, T
D'Arcangelo, N
Fine, T
Reed, PL
Calabrese, JR
Galea, S
AF Fink, David S.
Gallaway, M. Shayne
Tamburrino, Marijo B.
Liberzon, Israel
Chan, Philip
Cohen, Gregory H.
Sampson, Laura
Shirley, Edwin
Goto, Toyomi
D'Arcangelo, Nicole
Fine, Thomas
Reed, Philip L.
Calabrese, Joseph R.
Galea, Sandro
TI Onset of Alcohol Use Disorders and Comorbid Psychiatric Disorders in a
Military Cohort: Are there Critical Periods for Prevention of Alcohol
Use Disorders?
SO PREVENTION SCIENCE
LA English
DT Article
DE Prevention; Alcohol-related disorders; Mental disorder; Age of onset;
Military personnel
ID NATIONAL EPIDEMIOLOGIC SURVEY; SUBSTANCE USE DISORDERS; SELF-REPORTED
AGE; POSTTRAUMATIC-STRESS-DISORDER; MAJOR DEPRESSIVE DISORDER;
MENTAL-HEALTH; ANXIETY DISORDERS; GUARD SOLDIERS; CHILDHOOD ADVERSITIES;
OF-ONSET
AB Alcohol use disorders (AUD) are commonly comorbid with anxiety and mood disorders; however, a strategy for AUD prevention remains unclear in the presence of three competing etiological models that each recommends different high-risk groups. Therefore, the investigation of the three hypotheses in a characteristically unique cohort is critical to identifying pervasive characteristics of AUD that can inform a universal prevention strategy. The current study evaluated the temporality and onset of comorbid AUD and psychiatric disorders in a representative sample of 528 Ohio Army National Guard soldiers using structured clinical interviews from 2009 to 2012. We examined temporality both statistically and graphically to identify patterns that could inform prevention. General estimating equations with dichotomous predictor variables were used to estimate odds ratios between comorbid psychiatric disorders and AUDs. An annualized rate of 13.5 % persons per year was diagnosed with any AUD between 2010 and 2012. About an equal proportion of participants with comorbid psychiatric disorders and AUD initiated the psychiatric disorder prior to the AUD and half initiated the psychiatric disorder after the AUD. Regardless of onset, however, the majority (80 %) AUD initiated during a short interval between the ages of 16 and 23. Focused primary prevention during this narrow age range (16-23 years) may have the greatest potential to reduce population mental health burden of AUD, irrespective of the sequencing of comorbid psychiatric disorder.
C1 [Fink, David S.; Cohen, Gregory H.] Mailman Sch Publ Hlth, Dept Epidemiol, 722 W 168th St,Room 1513, New York, NY 10032 USA.
[Gallaway, M. Shayne] US Army Garrison Ansbach, US Army, Subst Abuse Program, Ansbach, Germany.
[Tamburrino, Marijo B.; Fine, Thomas] Univ Toledo, Dept Psychiat, 2801 W Bancroft St, Toledo, OH 43606 USA.
[Liberzon, Israel] Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA.
[Chan, Philip; Shirley, Edwin; Goto, Toyomi; D'Arcangelo, Nicole; Calabrese, Joseph R.] Case Western Reserve Univ, Univ Hosp, Case Med Ctr, Dept Psychiat, Cleveland, OH 44106 USA.
[Sampson, Laura; Galea, Sandro] Boston Univ, Sch Publ Hlth, Boston, MA 02215 USA.
[Reed, Philip L.] Michigan State Univ, Biomed Res & Informat Ctr, Ann Arbor, MI USA.
RP Fink, DS (reprint author), Mailman Sch Publ Hlth, Dept Epidemiol, 722 W 168th St,Room 1513, New York, NY 10032 USA.
EM dsf2130@columbia.edu
OI Liberzon, Israel/0000-0002-4990-556X; Fink, David/0000-0003-1531-1525
FU Office of the Assistant Secretary of Defense for Health Affairs through
the Joint Warfighter Medical Research Program [W81XWH-15-1-0080,
W81XWH-07-1-0409, W81XWH-10-1-0579]; US Army Medical Research
Acquisition Activity, Chandler Street, Fort Detrick MD; National
Institute on Drug Abuse [T32DA031099]
FX This work was supported by the Office of the Assistant Secretary of
Defense for Health Affairs through the Joint Warfighter Medical Research
Program under Award No. W81XWH-15-1-0080, W81XWH-07-1-0409, and
W81XWH-10-1-0579 [DSF, MTB, IL, PC, GHC, LS, ES, TG, ND, TF, PLR, JRC,
SG]. The US Army Medical Research Acquisition Activity, 820 Chandler
Street, Fort Detrick MD 21702-5014 is the awarding and administering
acquisition office. Opinions, interpretations, conclusions, and
recommendations are those of the author and are not necessarily endorsed
by the Department of Defense. This report was supported by National
Institute on Drug Abuse grant T32DA031099 [DSF]. The informatics support
for this research was provided by the Michigan State University Clinical
and Translational Sciences Institute, through its Biomedical Research
Informatics Core.
NR 46
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U1 2
U2 4
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1389-4986
EI 1573-6695
J9 PREV SCI
JI Prev. Sci.
PD APR
PY 2016
VL 17
IS 3
BP 347
EP 356
DI 10.1007/s11121-015-0624-1
PG 10
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA DG7LT
UT WOS:000372266500007
PM 26687202
ER
PT J
AU Merbah, M
Onkar, S
Grivel, JC
Vanpouille, C
Biancotto, A
Bonar, L
Sanders-Buell, E
Kijak, G
Michael, N
Robb, M
Kim, JH
Tovanabutra, S
Chenine, AL
AF Merbah, Melanie
Onkar, Sayali
Grivel, Jean-Charles
Vanpouille, Christophe
Biancotto, Angelique
Bonar, Lydia
Sanders-Buell, Eric
Kijak, Gustavo
Michael, Nelson
Robb, Merlin
Kim, Jerome H.
Tovanabutra, Sodsai
Chenine, Agnes-Laurence
TI Standardization of a cytometric p24-capture bead-assay for the detection
of main HIV-1 subtypes
SO JOURNAL OF VIROLOGICAL METHODS
LA English
DT Article
DE HIV-1; p24; Detection; Multi-subtype; Multiplex assay
ID CELLS; REPLICATION; SUPPRESSION; INFECTION; PROTEIN; P24
AB The prevailing method to assess HIV-1 replication and infectivity is to measure the production of p24 Gag protein by enzyme-linked immunosorbent assay (ELISA). Since fluorescent bead-based technologies offer a broader dynamic range and higher sensitivity, this study describes a p24 capture Luminex assay capable of detecting HIV-1 subtypes A-D, circulating recombinant forms (CRF) CRF01_AE and CRF02_AG, which together are responsible for over 90% of HIV-1 infections worldwide. The success of the assay lies in the identification and selection of a cross-reactive capture antibody (clone 183-H12-5C). Fifty-six isolates that belonged to six HIV-1 subtypes and CRFs were successfully detected with p-values below 0.021; limits of detection ranging from 3.7 to 3 x 104 pg/ml. The intra- and inter-assay variation gave coefficient of variations below 6 and 14%, respectively.
The 183-bead Luminex assay also displayed higher sensitivity of 91% and 98% compared to commercial p24 ELISA and a previously described Luminex assay. The p24 concentrations measured by the 183 bead Luminex assay showed a significant correlation (R=0.92, p < 0.0001) with the data obtained from quantitative real time PCR.
This newly developed p24 assay leverages the advantages of the Luminex platform, which include smaller sample volume and simultaneous detection of up to 500 analytes in a single sample, and delivers a valuable tool for the field. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Merbah, Melanie; Onkar, Sayali; Bonar, Lydia; Sanders-Buell, Eric; Kijak, Gustavo; Michael, Nelson; Robb, Merlin; Kim, Jerome H.; Tovanabutra, Sodsai; Chenine, Agnes-Laurence] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA.
[Merbah, Melanie; Onkar, Sayali; Bonar, Lydia; Sanders-Buell, Eric; Kijak, Gustavo; Robb, Merlin; Tovanabutra, Sodsai; Chenine, Agnes-Laurence] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
[Grivel, Jean-Charles; Vanpouille, Christophe] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Phys Biol, NIH, Bethesda, MD USA.
[Biancotto, Angelique] NIH, Ctr Human Immunol Autoimmun & Inflammat, Bldg 10, Bethesda, MD 20892 USA.
RP Merbah, M (reprint author), Walter Reed Army Inst Res, MHRP, 503 Robert Grant Ave,Room 2N11, Silver Spring, MD 20910 USA.; Merbah, M (reprint author), Walter Reed Army Inst Res, Henry M Jackson Fdn Adv Mil Med HJF, 503 Robert Grant Ave,Room 2N11, Silver Spring, MD 20910 USA.
EM mmerbah@hivresearch.org; sonkar@hivresearch.org; jgrivel@sidra.org;
vanpouic@mail.nih.gov; biancoa@nhlbi.nih.gov; lbonar@hivresearch.org;
esanders-buell@hivresearch.org; gkijak@hivresearch.org;
nmichael@hivresearch.org; mrobb@hivresearch.org; jerome.kim@ivi.int;
stovanabutra@hivresearch.org; achenine@hivresearch.org
OI Merbah, Melanie/0000-0002-5641-8612
FU Henry M. Jackson Foundation for the Advancement of Military Medicine,
Inc. [W81XWH-11-2-0174]; U.S. Department of Defense (DoD)
[W81XWH-11-2-0174]
FX This work was supported by a cooperative agreement (W81XWH-11-2-0174)
between the Henry M. Jackson Foundation for the Advancement of Military
Medicine, Inc., and the U.S. Department of Defense (DoD). The views
expressed are those of the authors and should not be construed to
represent the positions of the United States Departments of the Army,
Defense, or Health and Human Services.
NR 24
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Z9 0
U1 1
U2 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-0934
EI 1879-0984
J9 J VIROL METHODS
JI J. Virol. Methods
PD APR
PY 2016
VL 230
BP 45
EP 52
DI 10.1016/j.jviromet.2016.01.009
PG 8
WC Biochemical Research Methods; Biotechnology & Applied Microbiology;
Virology
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
Virology
GA DG3DS
UT WOS:000371950300008
PM 26808359
ER
PT J
AU Ender, MG
Rohall, DE
Matthews, MD
AF Ender, Morten G.
Rohall, David E.
Matthews, Michael D.
TI Cadet and Civilian Undergraduate Attitudes toward Transgender People: A
Research Note
SO ARMED FORCES & SOCIETY
LA English
DT Article
DE transgender; military; undergraduates; attitudes; cadets; military
academy
ID MILITARY; GENDER; AFFILIATION
AB We explore American military academy, Reserve Officers' Training Corps (ROTC) and civilian undergraduate attitudes toward transgender people in general, in the workplace, and in the military. Earlier this decade, the US military experienced both the repeals of the Don't Ask, Don't Tell policy and the exclusion of women from combat, yet transgender people are prohibited from serving openly in the military. This study explores tolerance toward perceived gender nonconformity by military affiliation, race/ethnicity, sex, religious affiliation, and political leaning. Most members of our sample, regardless of military affiliation, do not report that having a transgender person in the workplace would impact their job. At first glance, military academy and ROTC cadets are least tolerant of transgender people in the military and in society more generally. Further analyses shows that the impact of military affiliation is reduced substantially by controlling for background characteristics, especially political ideology and religious affiliation.
C1 [Ender, Morten G.; Matthews, Michael D.] US Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA.
[Rohall, David E.] Missouri State Univ, Dept Sociol & Anthropol, Springfield, MO USA.
RP Ender, MG (reprint author), US Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA.
EM morten.ender@usma.edu
FU Palm Center; Faculty Development Research Grant through the United
States Military Academy
FX The authors disclosed the receipt of the following financial support for
the research, authorship and/or publication of this article: Partial
funding for this project was received from the Palm Center and a Faculty
Development Research Grant through the United States Military Academy.
NR 16
TC 0
Z9 0
U1 2
U2 6
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0095-327X
EI 1556-0848
J9 ARMED FORCES SOC
JI Armed Forces Soc.
PD APR
PY 2016
VL 42
IS 2
BP 427
EP 435
DI 10.1177/0095327X15575278
PG 9
WC Political Science; Sociology
SC Government & Law; Sociology
GA DF4GZ
UT WOS:000371307300009
ER
PT J
AU Tweedell, AJ
Ryan, ED
Scharville, MJ
Rosenberg, JG
Sobolewski, EJ
Kleinberg, CR
AF Tweedell, Andrew J.
Ryan, Eric D.
Scharville, Michael J.
Rosenberg, Joseph G.
Sobolewski, Eric J.
Kleinberg, Craig R.
TI The influence of ultrasound measurement techniques on the age-related
differences in Achilles tendon size
SO EXPERIMENTAL GERONTOLOGY
LA English
DT Article
DE Cross-sectional area; Thickness; Aging; Reliability
ID CROSS-SECTIONAL AREA; TEST-RETEST RELIABILITY; IN-VIVO; PATELLAR TENDON;
DOMINANCE; STRESS; ANKLE
AB Achilles tendon (AT) properties change with age, however the extent to which aging influences the size of the AT may be influenced by the measurement technique. The purpose of this study was to 1) examine the age-related differences in AT size using measures of cross-sectional area (CSA) and thickness, and 2) to determine the test-retest reliability and minimum difference (MD) values of these measures. The size of the AT was examined in 19 young (19.79 +/- 2.3 years) and 18 older (69.4 +/- 3.1 years) healthy men on two separate occasions using an ultrasonography. The CSA and thickness of the AT were determined by separate transverse and longitudinal scans on the right leg at the same distance from the medial malleolus, respectively. Prior to and after accounting for body mass, AT CSA was larger (P <= 0.01) in the older men (64.49 +/- 13.87 mm(2)) when compared to the younger men (44.12 +/- 16.04 mm(2)), however there were no differences in AT thickness between age groups (P = 0.96). In addition, there was no systematic error (P > 0.05) between testing days, and the intraclass correlation coefficients, standard error of measurement (expressed as a % of the mean), and MD values for CSA and thickness ranged from 0.80-0.98, 5.46-8.68%, and 5.65-7.94 mm(2) and 0.51-0.86 mm, respectively between both groups. These findings suggest that the reliability of the CSA and thickness measurements were similar, however, CSA was a more sensitive measure to detect the age-related changes of AT size. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Tweedell, Andrew J.; Ryan, Eric D.; Kleinberg, Craig R.] Univ N Carolina, Dept Exercise & Sport Sci, Neuromuscular Res Lab, Chapel Hill, NC USA.
[Tweedell, Andrew J.] Army Res Lab, Aberdeen, MD USA.
[Ryan, Eric D.] Univ N Carolina, Allied Hlth Sci, Chapel Hill, NC USA.
[Scharville, Michael J.] Quintiles Inc, Durham, NC USA.
[Rosenberg, Joseph G.] Valencell Inc, Raleigh, NC USA.
[Sobolewski, Eric J.] Texas Tech Univ, Dept Kinesiol & Sport Management, Human Performance Lab, Lubbock, TX 79409 USA.
RP Ryan, ED (reprint author), Univ N Carolina, Dept Exercise & Sports Sci, 209 Fetzer Hall,CB 8700, Chapel Hill, NC 27599 USA.; Ryan, ED (reprint author), Univ N Carolina, Allied Hlth Sci, 209 Fetzer Hall,CB 8700, Chapel Hill, NC 27599 USA.
EM edryan@email.unc.edu
NR 16
TC 2
Z9 2
U1 0
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0531-5565
EI 1873-6815
J9 EXP GERONTOL
JI Exp. Gerontol.
PD APR
PY 2016
VL 76
BP 68
EP 71
DI 10.1016/j.exger.2016.01.015
PG 4
WC Geriatrics & Gerontology
SC Geriatrics & Gerontology
GA DF4XQ
UT WOS:000371355200009
PM 26827613
ER
PT J
AU Sviatenko, LK
Gorb, L
Shukla, MK
Seiter, JM
Leszczynska, D
Leszczynski, J
AF Sviatenko, Liudmyla K.
Gorb, Leonid
Shukla, Manoj K.
Seiter, Jennifer M.
Leszczynska, Danuta
Leszczynski, Jerzy
TI Adsorption of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane
(CL-20) on a soil organic matter. A DFT M05 computational study
SO CHEMOSPHERE
LA English
DT Article
DE Leonardite humic acid; Adsorption; AIM method; Redox potential; CL-20
ID ELECTRON-DENSITIES; ENVIRONMENTAL FATE; EXPLOSIVE CL-20; HYDROGEN-BONDS;
MECHANISMS; REDUCTION; ACCURACY
AB Adsorption of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20) by soil organic matter considering the Leonardite Humic Acid (LHA) model at the M05/tzvp level of Density Functional Theory. (DFT) applying cluster approximation has been investigated. Different orientations of CL-20 toward LHA surface were examined. It was found that deprotonation of LHA is required to obtain stable complexes with CL-20. Hydrogen bonds between CL-20 and deprotonated LHA were analyzed applying the atoms in molecules (AIM) theory. An attachment or removal of an electron with respect to the complex does not have significant effect on mutual orientation of the adsorbent in complexes. It was shown that adsorbed CL-20 does not undergo redox transformation and, therefore, adsorption on soil organic matter may be responsible for decrease of the degradation rate of CL-20 in soil. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Sviatenko, Liudmyla K.; Leszczynski, Jerzy] Jackson State Univ, Dept Chem & Biochem, Interdisciplinary Ctr Nanotox, 1325 JR Lynch St,POB 17910, Jackson, MS 39217 USA.
[Sviatenko, Liudmyla K.] Oles Honchar Dnipropetrovsk Natl Univ, Dept Organ Chem, UA-49000 Dnepropetrovsk, Ukraine.
[Gorb, Leonid] HX5 LLC, Vicksburg, MS 39180 USA.
[Shukla, Manoj K.; Seiter, Jennifer M.] Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
[Leszczynska, Danuta] Jackson State Univ, Dept Civil & Environm Engn, Interdisciplinary Ctr Nanotox, Jackson, MS 39217 USA.
RP Leszczynski, J (reprint author), Jackson State Univ, Dept Chem & Biochem, Interdisciplinary Ctr Nanotox, 1325 JR Lynch St,POB 17910, Jackson, MS 39217 USA.
EM jerzy@icnanotox.org
OI Shukla, Manoj /0000-0002-7560-1172
FU ERDC [W912HZ-13-P-0037]; National Science Foundation [OCI-1053575];
XSEDE award [DMR110088]
FX We (DL and JL) thank ERDC for financial support (grant number is
W912HZ-13-P-0037). The computation time was provided by the Extreme
Science and Engineering Discovery Environment (XSEDE) by National
Science Foundation Grant Number OCI-1053575 and XSEDE award allocation
Number DMR110088 and by the Mississippi Center for Supercomputer
Research.
NR 32
TC 1
Z9 1
U1 6
U2 23
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0045-6535
EI 1879-1298
J9 CHEMOSPHERE
JI Chemosphere
PD APR
PY 2016
VL 148
BP 294
EP 299
DI 10.1016/j.chemosphere.2016.01.011
PG 6
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA DF1KX
UT WOS:000371099700036
PM 26814703
ER
PT J
AU Golius, A
Gorb, L
Scott, AM
Hill, FC
Shukla, M
Goins, AB
Johnson, DR
Leszczynski, J
AF Golius, Anastasiia
Gorb, Leonid
Scott, Andrea Michalkova
Hill, Frances C.
Shukla, Manoj
Goins, A. Benjamin
Johnson, David R.
Leszczynski, Jerzy
TI Experimental and computational study of membrane affinity for selected
energetic compounds
SO CHEMOSPHERE
LA English
DT Article
DE Partition coefficient; Artificial bilayer lipid membranes; Energetic
compounds; Theoretical study
ID MOLECULAR-DYNAMICS SIMULATIONS; WATER PARTITION-COEFFICIENTS;
LIPID-BILAYERS; POLYCHLORINATED-BIPHENYLS; ORGANIC-CHEMICALS;
PREDICTION; BASES; ACIDS; ACCUMULATE; SURFACE
AB The affinity of various energetic compounds for a biological membrane was investigated using experimental and computational techniques. We measured octanol-water (log(K-ow)) and liposome-water (log(K-lipw)) partition coefficients for the following chemicals: trinitrotoluene (TNT), 2,4-dinitrotoluene (2,4-DNT), 2,6-dinitrotoluene (2,6-DNT), 2,4-dinitroanisole (DNAN), 2methoxy-5-nitrophenol (2M5NP), 2,4,6-trinitrobenzene (TNB), and 2,4-dinitrophenol (2,4-DNP). In order to determine log(Klipw) experimentally, we used artificial solid supported lipid liposomes produced under trade mark TRANSIL. Log(K-ow) value were predicted with several program packages including the COSMOthermX software. Log(K-lipw) were estimated with COSMOmic as implemented in the COSMOthermX program package. In order to verify accuracy of our experimentally obtained results, we performed basic statistical analysis of data taken from the literature. We concluded that compounds considered in this study possess a moderate ability to penetrate into membranes. Comparison of both coefficients has shown that in general, the log(K-ow) values are slightly smaller than log(K-lipw). (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Golius, Anastasiia; Leszczynski, Jerzy] Jackson State Univ, Dept Chem & Biochem, Jackson, MS 39217 USA.
[Gorb, Leonid] HX5 LLC, Vicksburg, MS USA.
[Scott, Andrea Michalkova; Hill, Frances C.; Shukla, Manoj] US Army Engineer Res & Dev Ctr, Vicksburg, MS USA.
[Goins, A. Benjamin] iMedDo Inc, POB 137103, Ft Worth, TX 76136 USA.
[Johnson, David R.] Conostoga Rovers & Associates, Dallas, TX USA.
RP Leszczynski, J (reprint author), Jackson State Univ, Dept Chem & Biochem, Interdisciplinary Ctr Nanotox, 1400 JR Lynch St,POB 17910, Jackson, MS 39217 USA.
EM jerzy@icnanotox.org
FU NSF CREST Interdisciplinary Nanotoxicity Center NSF-CREST - Grant
[HRD-0833178]; Extreme Science and Engineering Discovery Environment
(XSEDE) by National Science Foundation [OCI-1053575]; XSEDE award
[DMR110088]; Environmental Quality Technology Program of the United
States Army Corps of Engineers by the U.S. Army ERDC
FX The authors thank the support of the NSF CREST Interdisciplinary
Nanotoxicity Center NSF-CREST - Grant # HRD-0833178; This research was
supported in part by the Extreme Science and Engineering Discovery
Environment (XSEDE) by National Science Foundation grant number
OCI-1053575 and XSEDE award allocation number DMR110088. The authors are
grateful to the Mississippi Center for Supercomputing Research (MCSR)
for providing state-of-the-art high performance computing facilities and
excellent services for supporting this research.; The use of trade,
product, or firm names in this report is for descriptive purposes only
and does not imply endorsement by the U.S. Government. Results in this
study were funded and obtained from research conducted under the
Environmental Quality Technology Program of the United States Army Corps
of Engineers by the U.S. Army ERDC. Permission was granted by the Chief
of Engineers to publish this information. The findings of this report
are not to be construed as an official Department of the Army position
unless so designated by other authorized documents.
NR 51
TC 0
Z9 0
U1 2
U2 15
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0045-6535
EI 1879-1298
J9 CHEMOSPHERE
JI Chemosphere
PD APR
PY 2016
VL 148
BP 322
EP 327
DI 10.1016/j.chemosphere.2016.01.010
PG 6
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA DF1KX
UT WOS:000371099700040
PM 26820779
ER
PT J
AU Walker, RW
Ashton, NK
Brown, RS
Liss, SA
Colotelo, AH
Beirao, BV
Townsend, RL
Deng, ZD
Eppard, MB
AF Walker, Ricardo W.
Ashton, Neil K.
Brown, Richard S.
Liss, Stephanie A.
Colotelo, Alison H.
Beirao, Bernardo V.
Townsend, Richard L.
Deng, Z. Daniel
Eppard, M. Brad
TI Effects of a novel acoustic transmitter on swimming performance and
predator avoidance of juvenile Chinook Salmon: Determination of a size
threshold
SO FISHERIES RESEARCH
LA English
DT Article
DE Behavior; Dam passage; Juvenile Salmon Acoustic Telemetry System;
Migration; Telemetry
ID EXTERNALLY ATTACHED TRANSMITTERS; RADIO TRANSMITTERS; MAXIMUM TAG; COHO
SALMON; GROWTH; IMPLANTATION; SURVIVAL; TROUT; PHYSIOLOGY; RETENTION
AB The miniaturization of acoustic transmitters enables researchers to tag smaller fish for telemetry studies, thus representing a greater proportion of the population of interest. Fish having a smaller transmitter burden (e.g., the weight of the transmitter relative to the weight of the fish) may also have fewer potential adverse transmitter effects. The development of an injectable acoustic transmitter has led to research that determined the least invasive and quickest method of implantation. Following that research, the objectives of this study were to determine the effects of transmitter implantation on swimming performance and predator avoidance, and to find a minimum size threshold of fish that can be tagged without adversely affecting those responses. To assess critical swimming speed (U-crit; an index of prolonged swimming performance) and predator avoidance for juvenile Chinook Salmon (Oncorhynchus tshawytscha), fish were split into three treatments: (1) implantation with a dummy injectable acoustic transmitter (IAT treatment), (2) implantation with a dummy injectable acoustic transmitter and passive integrated transponder tag (IAT + PIT treatment), and (3) an untagged control. IAT treatment fish had lower U-crit values than untagged controls among individuals below 79 mm fork length (transmitter burden 3.4-4.0%). U-crit values for the IAT + PIT treatment were not significantly different from untagged controls and no size threshold was found. There was no significant difference in predator avoidance between fish implanted with the IAT or IAT + PIT compared to untagged controls. These guidelines could provide researchers and managers with a powerful tool to examine behavior and survival of small salmonids. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Walker, Ricardo W.; Ashton, Neil K.; Brown, Richard S.; Liss, Stephanie A.; Colotelo, Alison H.] Pacific NW Natl Lab, Ecol Grp, Richland, WA 99352 USA.
[Beirao, Bernardo V.] Univ Fed Sao Joao del Rei, Ouro Branco, MG, Brazil.
[Townsend, Richard L.] Univ Washington, Sch Aquat & Fishery Sci, Columbia Basin Res, Seattle, WA 98101 USA.
[Deng, Z. Daniel] Pacific NW Natl Lab, Hydrol Grp, Richland, WA 99352 USA.
[Eppard, M. Brad] US Army Corps Engineers, Portland, OR 97208 USA.
RP Liss, SA (reprint author), Pacific NW Natl Lab, Ecol Grp, Richland, WA 99352 USA.
EM stephanie.liss@pnnl.gov
RI Deng, Daniel/A-9536-2011
OI Deng, Daniel/0000-0002-8300-8766
FU Army Corps of Engineers, Portland District
FX We would like to the thank the Army Corps of Engineers, Portland
District, for providing the funding for this research. We would also
like to thank the Washington Department of Fish and Wildlife Leavenworth
and Priest Rapids Hatcheries for providing the salmon used in this
study. We also thank John Skalski from the University of Washington for
statistical advice and Thomas Hancock from Portland State University for
providing assistance with the swimming chambers. We appreciate the
assistance from the following PNNL staff Zach Booth, Nikki Fuller, David
Geist, Jill Janak, Brian Jeide, Bryan Jones, Ki Won Jung, Tim Linley,
Jun Lu, Jayson Martinez, Brett Pflugrath, Jason Reynolds, and John
Stephenson.
NR 30
TC 4
Z9 4
U1 4
U2 24
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-7836
EI 1872-6763
J9 FISH RES
JI Fish Res.
PD APR
PY 2016
VL 176
BP 48
EP 54
DI 10.1016/j.fishres.2015.12.007
PG 7
WC Fisheries
SC Fisheries
GA DE0HZ
UT WOS:000370307000006
ER
PT J
AU Bernstock, JD
Budinich, CS
Cohen, LG
Awosika, OO
AF Bernstock, Joshua D.
Budinich, Craig S.
Cohen, Leonardo G.
Awosika, Oluwole O.
TI Recrudescence of Focal stroke symptoms during pain Management with
Hydromorphone
SO FRONTIERS IN NEUROLOGY
LA English
DT Article
DE stroke; pain management; opioids; plasticity; recrudescence of symptoms
ID NEUROLOGICAL DEFICITS; MIDAZOLAM CHALLENGE; OPIOID RECEPTORS; NALOXONE;
RECOVERY; REVERSAL; MEMORY
AB Patients who have recovered from a prior stroke may experience a reemergence of their original stroke syndrome secondary to metabolic derangements, sedation, infection, and/or fatigue. Critically, the molecular/cellular mechanisms mediating symptom recurrence after exposure to analgesic agents remain unknown. Accordingly, herein, we report a unique case of a patient with hydromorphone-induced recrudescence 30 years after her initial stroke event(s) and in so doing propose a putative mechanism related to post-infarction functional neuroplasticity.
C1 [Bernstock, Joshua D.] NINDS, Stroke Sect, NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA.
[Budinich, Craig S.] Dwight D Eisenhower Army Med Ctr, Dept Anesthesiol, Ft Gordon, GA USA.
[Cohen, Leonardo G.; Awosika, Oluwole O.] NINDS, Human Cort Physiol & Stroke Neurorehabil Sect, NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA.
RP Awosika, OO (reprint author), NINDS, Human Cort Physiol & Stroke Neurorehabil Sect, NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA.
EM awosikaoo@ninds.nih.gov
FU Intramural Research Program of the National Institute of Neurological
Disorders and Stroke, National Institutes of Health (NINDS/NIH)
FX The authors disclosed receipt of the following financial support for the
research, authorship, and/or publication of this article: this work was
supported by the Intramural Research Program of the National Institute
of Neurological Disorders and Stroke, National Institutes of Health
(NINDS/NIH).
NR 18
TC 0
Z9 0
U1 1
U2 2
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015,
SWITZERLAND
SN 1664-2295
J9 FRONT NEUROL
JI Front. Neurol.
PD MAR 31
PY 2016
VL 7
AR 50
DI 10.3389/fneur.2016.00050
PG 3
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA DI0IH
UT WOS:000373178400001
PM 27064505
ER
PT J
AU Stefan, CP
Chase, K
Coyne, S
Kulesh, DA
Minogue, TD
Koehler, JW
AF Stefan, Christopher P.
Chase, Kitty
Coyne, Susan
Kulesh, David A.
Minogue, Timothy D.
Koehler, Jeffrey W.
TI Development of real-time reverse transcriptase qPCR assays for the
detection of Punta Toro virus and Pichinde virus
SO VIROLOGY JOURNAL
LA English
DT Article
DE Real-time RT-qPCR; Pichinde virus; Punta Toro virus; Bunyaviruses;
Arenaviruses
ID RIFT-VALLEY FEVER; SAUDI-ARABIA; LASSA FEVER; GUINEA-PIGS; INFECTION;
HAMSTERS; DISEASE; PHLEBOVIRUS; RIBAVIRIN; MODEL
AB Background: Research with high biocontainment pathogens such as Rift Valley fever virus (RVFV) and Lassa virus (LASV) is expensive, potentially hazardous, and limited to select institutions. Surrogate pathogens such as Punta Toro virus (PTV) for RVFV infection and Pichinde virus (PICV) for LASV infection allow research to be performed under more permissive BSL-2 conditions. Although used as infection models, PTV and PICV have no standard real-time RT-qPCR assays to detect and quantify pathogenesis. PTV is also a human pathogen, making a standardized detection assay essential for biosurveillance. Here, we developed and characterized two real-time RT-qPCR assays for PICV and PTV by optimizing assay conditions and measuring the limit of detection (LOD) and performance in multiple clinical matrices.
Methods: Total nucleic acid from virus-infected Vero E6 cells was used to optimize TaqMan-minor groove binder (MGB) real-time RT-qPCR assays. A 10-fold dilution series of nucleic acid was used to perform analytical experiments with 60 replicates used to confirm assay LODs. Serum and whole blood spiked with 10-fold dilutions of PTV and PICV virus were assessed as matrices in a mock clinical context. The Cq, or cycle at which the fluoresce of each sample first crosses a threshold line, was determined using the second derivative method using Roche LightCycler 480 software version 1.5.1. Digital droplet PCR (ddPCR) was utilized to quantitatively determine RNA target counts/mu l for PTV and PICV.
Results: Optimized PTV and PICV assays had LODs of 1000 PFU/ml and 100 PFU/ml, respectively, and this LOD was confirmed in 60/60 (PTV) and 58/60 (PICV) positive replicates. Preliminary mock clinical LODs remained consistent in serum and whole blood for PTV and PICV at 1000 PFU/ml and 100 PFU/ml. An exclusivity panel showed no cross reaction with near neighbors.
Conclusions: PTV and PICV Taq-man MGB based real-time RT-qPCR assays developed here showed relevant sensitivity and reproducibility in samples extracted from a variety of clinical matrices. These assays will be useful as a standard by researchers for future experiments utilizing PTV and PICV as infection models, offering the ability to track infection and viral replication kinetics during research studies.
C1 [Stefan, Christopher P.; Chase, Kitty; Coyne, Susan; Kulesh, David A.; Minogue, Timothy D.; Koehler, Jeffrey W.] US Army, Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA.
RP Koehler, JW (reprint author), US Army, Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA.
EM jeff.w.koehler.ctr@mail.mil
OI Koehler, Jeffrey/0000-0003-3225-6599
FU Defense Threat Reduction Agency (DTRA) [11467651]
FX This work was supported by the Defense Threat Reduction Agency (DTRA)
11467651. The opinions, interpretations, conclusions, and
recommendations contained herein are those of the authors and are not
necessarily endorsed by the U.S. Army. The authors would also like to
thank Cindy Rossi and the UCC for supplying some of the viruses used in
the studies
NR 29
TC 2
Z9 2
U1 1
U2 5
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1743-422X
J9 VIROL J
JI Virol. J.
PD MAR 31
PY 2016
VL 13
AR 54
DI 10.1186/s12985-016-0509-3
PG 6
WC Virology
SC Virology
GA DI1OK
UT WOS:000373265200001
PM 27029488
ER
PT J
AU Subramanian, V
Semenzin, E
Hristozov, D
Zabeo, A
Malsch, I
McAlea, E
Murphy, F
Mullins, M
van Harmelen, T
Ligthart, T
Linkov, I
Marcomini, A
AF Subramanian, Vrishali
Semenzin, Elena
Hristozov, Danail
Zabeo, Alex
Malsch, Ineke
McAlea, Eamonn
Murphy, Finbarr
Mullins, Martin
van Harmelen, Toon
Ligthart, Tom
Linkov, Igor
Marcomini, Antonio
TI Sustainable nanotechnology decision support system: bridging risk
management, sustainable innovation and risk governance
SO JOURNAL OF NANOPARTICLE RESEARCH
LA English
DT Article
DE Decision support system; Sustainable nanotechnology; Risk governance;
Risk management; Engineered nanomaterials
ID LIFE-CYCLE ASSESSMENT; ENGINEERED NANOMATERIALS
AB The significant uncertainties associated with the (eco)toxicological risks of engineered nanomaterials pose challenges to the development of nanoenabled products toward greatest possible societal benefit. This paper argues for the use of risk governance approaches to manage nanotechnology risks and sustainability, and considers the links between these concepts. Further, seven risk assessment and management criteria relevant to risk governance are defined: (a) life cycle thinking, (b) triple bottom line, (c) inclusion of stakeholders, (d) risk management, (e) benefitrisk assessment, (f) consideration of uncertainty, and (g) adaptive response. These criteria are used to compare five well-developed nanotechnology frameworks: International Risk Governance Council framework, Comprehensive Environmental Assessment, Streaming Life Cycle Risk Assessment, Certifiable Nanospecific Risk Management and Monitoring System and LICARA NanoSCAN. A Sustainable Nanotechnology Decision Support System (SUNDS) is proposed to better address current nanotechnology risk assessment and management needs, and makes. Stakeholder needs were solicited for further SUNDS enhancement through a stakeholder workshop that included representatives from regulatory, industry and insurance sectors. Workshop participants expressed the need for the wider adoption of sustainability assessment methods and tools for designing greener nanomaterials.
C1 [Subramanian, Vrishali; Semenzin, Elena; Hristozov, Danail; Zabeo, Alex; Linkov, Igor; Marcomini, Antonio] Univ Ca Foscari Venice, Dept Environm Sci Informat & Stat, Venice, Italy.
[Malsch, Ineke] Malsch TechnoValuat, Utrecht, Netherlands.
[McAlea, Eamonn; Murphy, Finbarr; Mullins, Martin] Univ Limerick, Kemmy Business Sch, Limerick, Ireland.
[van Harmelen, Toon; Ligthart, Tom] TNO, Utrecht, Netherlands.
[Linkov, Igor] US Army Engineer Res & Dev Ctr, Concord, MA USA.
RP Marcomini, A (reprint author), Univ Ca Foscari Venice, Dept Environm Sci Informat & Stat, Venice, Italy.
EM vrishali.subramanian@unive.it; marcom@unive.it
RI Murphy, Finbarr/B-5254-2015; Zabeo, Alex/D-6715-2014;
OI Murphy, Finbarr/0000-0002-7463-7923; Zabeo, Alex/0000-0001-7162-5364;
Hristozov, Danail/0000-0002-2386-7366
FU European Union Seventh Framework Programme under ECGA [604305]
FX This study was funded in part by the European Union Seventh Framework
Programme [FP7/2007-2013] under ECGA No. 604305 "SUN''. This publication
reflects the views only of the authors, and the European Commission and
other sponsors cannot be held responsible for any use, which may be made
of the information contained therein.
NR 63
TC 3
Z9 3
U1 11
U2 23
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1388-0764
EI 1572-896X
J9 J NANOPART RES
JI J. Nanopart. Res.
PD MAR 30
PY 2016
VL 18
IS 4
AR UNSP 89
DI 10.1007/s11051-016-3375-4
PG 13
WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials
Science, Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA DI2ZK
UT WOS:000373367700001
ER
PT J
AU Timmermans, A
Melendrez, MC
Se, Y
Chuang, I
Samon, N
Uthaimongkol, N
Klungthong, C
Manasatienkij, W
Thaisomboonsuk, B
Tyner, SD
Rith, S
Horm, VS
Jarman, RG
Bethell, D
Chanarat, N
Pavlin, J
Wongstitwilairoong, T
Saingam, P
El, BS
Fukuda, MM
Touch, S
Sovann, L
Fernandez, S
Buchy, P
Chanthap, L
Saunders, D
AF Timmermans, Ans
Melendrez, Melanie C.
Se, Youry
Chuang, Ilin
Samon, Nou
Uthaimongkol, Nichapat
Klungthong, Chonticha
Manasatienkij, Wudtichai
Thaisomboonsuk, Butsaya
Tyner, Stuart D.
Rith, Sareth
Horm, Viseth Srey
Jarman, Richard G.
Bethell, Delia
Chanarat, Nitima
Pavlin, Julie
Wongstitwilairoong, Tippa
Saingam, Piyaporn
El, But Sam
Fukuda, Mark M.
Touch, Sok
Sovann, Ly
Fernandez, Stefan
Buchy, Philippe
Chanthap, Lon
Saunders, David
TI Human Sentinel Surveillance of Influenza and Other Respiratory Viral
Pathogens in Border Areas of Western Cambodia
SO PLOS ONE
LA English
DT Article
ID MOUTH-DISEASE OUTBREAK; A VIRUS; PHYLOGENETIC ANALYSIS; ANTIGENIC
VARIATION; CLINICAL SPECIMENS; SEQUENCE ALIGNMENT; EVOLUTION; CHILDREN;
HEMAGGLUTININ; DATAMONKEY
AB Little is known about circulation of influenza and other respiratory viruses in remote populations along the Thai-Cambodia border in western Cambodia. We screened 586 outpatients (median age 5, range 1-77) presenting with influenza-like-illness (ILI) at 4 sentinel sites in western Cambodia between May 2010 and December 2012. Real-time reverse transcriptase (rRT) PCR for influenza was performed on combined nasal and throat specimens followed by viral culture, antigenic analysis, antiviral susceptibility testing and full genome sequencing for phylogenetic analysis. ILI-specimens negative for influenza were cultured, followed by rRT-PCR for enterovirus and rhinovirus (EV/RV) and EV71. Influenza was found in 168 cases (29%) and occurred almost exclusively in the rainy season from June to November. Isolated influenza strains had close antigenic and phylogenetic relationships, matching vaccine and circulating strains found elsewhere in Cambodia. Influenza vaccination coverage was low (<20%). Western Cambodian H1N1(2009) isolate genomes were more closely related to 10 earlier Cambodia isolates (94.4% genome conservation) than to 13 Thai isolates (75.9% genome conservation), despite sharing the majority of the amino acid changes with the Thai references. Most genes showed signatures of purifying selection. Viral culture detected only adenovirus (5.7%) and parainfluenza virus (3.8%), while non-polio enteroviruses (10.3%) were detected among 164 culture-negative samples including coxsackievirus A4, A6, A8, A9, A12, B3, B4 and echovirus E6 and E9 using nested RT-PCR methods. A single specimen of EV71 was found. Despite proximity to Thailand, influenza epidemiology of these western Cambodian isolates followed patterns observed elsewhere in Cambodia, continuing to support current vaccine and treatment recommendations from the Cambodian National Influenza Center. Amino acid mutations at non-epitope sites, particularly hemagglutinin genes, require further investigation in light of an increasingly important role of permissive mutations in influenza virus evolution. Further research about the burden of adenovirus and non-polio enteroviruses as etiologic agents in acute respiratory infections in Cambodia is also needed.
C1 [Timmermans, Ans; Chuang, Ilin; Tyner, Stuart D.; Bethell, Delia; Fukuda, Mark M.; Fernandez, Stefan; Saunders, David] US Armed Forces Res Inst Med Sci, Dept Immunol, Bangkok, Thailand.
[Melendrez, Melanie C.; Jarman, Richard G.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD USA.
[Se, Youry; Samon, Nou; El, But Sam] Armed Forces Res Inst Med Sci, Dept Immunol, Battambang, Cambodia.
[Uthaimongkol, Nichapat; Klungthong, Chonticha; Manasatienkij, Wudtichai; Thaisomboonsuk, Butsaya; Chanarat, Nitima; Wongstitwilairoong, Tippa; Saingam, Piyaporn] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand.
[Rith, Sareth; Horm, Viseth Srey; Buchy, Philippe] Inst Pasteur Cambodge, Dept Virol, Phnom Penh, Cambodia.
[Pavlin, Julie] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD USA.
[Touch, Sok; Sovann, Ly] Minist Hlth, Dept Communicable Dis Control, Phnom Penh, Cambodia.
[Chanthap, Lon] Armed Forces Res Inst Med Sci, Dept Immunol, Phnom Penh, Cambodia.
[Timmermans, Ans] Maastricht Univ, Fac Hlth Med & Life Sci, NL-6200 MD Maastricht, Netherlands.
[Tyner, Stuart D.] US Army Inst Surg Res, Houston, TX USA.
[Pavlin, Julie] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Henry M Jackson Fdn Adv Mil Med Inc, Bethesda, MD USA.
[Buchy, Philippe] GSK Vaccines, R&D, Singapore, Singapore.
RP Melendrez, MC (reprint author), Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD USA.
EM mmelendrez@gmail.com
OI Melendrez, Melanie/0000-0002-4811-4467
FU Armed Forces Health Surveillance Center's Global Emerging Infections and
Response System
FX Funding was provided by The Armed Forces Health Surveillance Center's
Global Emerging Infections and Response System. The funder had no role
in study design, data collection and analysis, decision to publish, or
preparation of the manuscript.
NR 53
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U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 30
PY 2016
VL 11
IS 3
AR e0152529
DI 10.1371/journal.pone.0152529
PG 23
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DH9LB
UT WOS:000373116500051
PM 27028323
ER
PT J
AU Mendoza, PA
Clark, MP
Mizukami, N
Gutmann, ED
Arnold, JR
Brekke, LD
Rajagopalan, B
AF Mendoza, Pablo A.
Clark, Martyn P.
Mizukami, Naoki
Gutmann, Ethan D.
Arnold, Jeffrey R.
Brekke, Levi D.
Rajagopalan, Balaji
TI How do hydrologic modeling decisions affect the portrayal of climate
change impacts?
SO HYDROLOGICAL PROCESSES
LA English
DT Article
DE climate change; hydrologic modelling; subjectivity; uncertainty
ID WESTERN UNITED-STATES; COLORADO RIVER-BASIN; METEOROLOGICAL FORCING
DATA; ASSIMILATION SYSTEM NLDAS; NORTH-AMERICAN CLIMATE; RAINFALL-RUNOFF
MODELS; SELF-ORGANIZING MAPS; CATCHMENT CLASSIFICATION; ASSESSING
UNCERTAINTIES; WINTER PRECIPITATION
AB End users face a range of subjective decisions when evaluating climate change impacts on hydrology, but the importance of these decisions is rarely assessed. In this paper, we evaluate the implications of hydrologic modelling choices on projected changes in the annual water balance, monthly simulated processes, and signature measures (i.e. metrics that quantify characteristics of the hydrologic catchment response) under a future climate scenario. To this end, we compare hydrologic changes computed with four different model structures - whose parameters have been obtained using a common calibration strategy - with hydrologic changes computed with a single model structure and parameter sets from multiple options for different calibration decisions (objective function, local optima, and calibration forcing dataset). Results show that both model structure selection and the parameter estimation strategy affect the direction and magnitude of projected changes in the annual water balance, and that the relative effects of these decisions are basin dependent. The analysis of monthly changes illustrates that parameter estimation strategies can provide similar or larger uncertainties in simulations of some hydrologic processes when compared with uncertainties coming from model choice. We found that the relative effects of modelling decisions on projected changes in catchment behaviour depend on the signature measure analysed. Furthermore, parameter sets with similar performance, but located in different regions of the parameter space, provide very different projections for future catchment behaviour. More generally, the results obtained in this study prompt the need to incorporate parametric uncertainty in multi-model frameworks to avoid an over-confident portrayal of climate change impacts. Copyright (c) 2015 John Wiley & Sons, Ltd.
C1 [Mendoza, Pablo A.; Rajagopalan, Balaji] Univ Colorado, Dept Civil Environm & Architectural Engn, Boulder, CO 80309 USA.
[Mendoza, Pablo A.; Rajagopalan, Balaji] Univ Colorado, Cooperat Inst Res Environm Sci, Boulder, CO 80309 USA.
[Mendoza, Pablo A.; Clark, Martyn P.; Mizukami, Naoki; Gutmann, Ethan D.] Natl Ctr Atmospher Res, Hydrometeorol Applicat Program, POB 3000, Boulder, CO 80307 USA.
[Arnold, Jeffrey R.] US Army, Corps Engn, Climate Preparedness & Resilience Programs, Seattle, WA USA.
[Brekke, Levi D.] Bur Reclamat, Denver, CO USA.
RP Mendoza, PA (reprint author), Natl Ctr Atmospher Res, Res Applicat Lab, POB 3000, Boulder, CO 80307 USA.
EM pmendoza@ucar.edu
RI Gutmann, Ethan/I-5728-2012
OI Gutmann, Ethan/0000-0003-4077-3430
FU U.S. Army Corps of Engineers; Bureau of Reclamation; Cooperative
Institute for Research and Environmental Sciences (CIRES); National
Science Foundation
FX We thank Oldrich Rakovec and Mary Hill for their feedback in the
implementation of DELSA, and Kyoko Ikeda for her help with WRF datasets.
We are also grateful to Marketa Elsner, Andy Newman, Michael Barlage,
Roland Viger, Adam Carheden, and Tor Mohling for their feedback and
assistance for setting up the models. This work was supported through a
contract with the U.S. Army Corps of Engineers, through a cooperative
agreement with the Bureau of Reclamation, and through a graduate
fellowship from the Cooperative Institute for Research and Environmental
Sciences (CIRES). The National Center for Atmospheric Research is
sponsored by the National Science Foundation. Finally, we thank two
anonymous reviewers for their highly constructive comments, which
contributed considerably to improve this manuscript.
NR 137
TC 3
Z9 3
U1 7
U2 20
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0885-6087
EI 1099-1085
J9 HYDROL PROCESS
JI Hydrol. Process.
PD MAR 30
PY 2016
VL 30
IS 7
BP 1071
EP 1095
DI 10.1002/hyp.10684
PG 25
WC Water Resources
SC Water Resources
GA DH8CR
UT WOS:000373021600005
ER
PT J
AU Varady, MJ
Pearl, TP
Stevenson, SM
Mantooth, BA
AF Varady, Mark J.
Pearl, Thomas P.
Stevenson, Shawn M.
Mantooth, Brent A.
TI Decontamination of VX from Silicone: Characterization of Multicomponent
Diffusion Effects
SO INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
LA English
DT Article
ID CHEMICAL WARFARE AGENTS; MODELING SORPTION; MASS-TRANSFER; DEGRADATION;
MIXTURES; SYSTEMS; PERVAPORATION; COEFFICIENTS; FORMULATION; SEPARATION
AB A continuum model of the transport and reaction processes occurring during decontamination of the chemical warfare agent (CWA) [2-(diisopropylamino)ethyl]-O-ethyl methylphosphonothioate (VX) absorbed in a-silicone elastomer using solutions of sodium hydroxide in water, methanol, and mixtures thereof is presented. This model is based on the Maxwell-Stefan formulation of multicomponent diffusion along with the Flory-Huggins model of thermodynamic equilibrium in the polymer. It was found that, as methanol from the decontaminant absorbs into the silicone, the diffusivity of VX increases, accelerating its flux from the polymer phase to the decontaminant liquid phase. This composition dependence of the diffusivity was accurately described by the Vignes equation. Although the decontamination kinetics were slower for the methanol-based decontaminant in a well-stirred liquid-phase reactor, the overall performance was superior compared to the aqueous-based decontaminant due to the enhanced extraction rate from the polymer. These findings highlight the need to consider extraction dynamics on equal footing with reaction kinetics when formulating decontaminants intended for use on absorbing polymer materials.
C1 [Varady, Mark J.; Pearl, Thomas P.] OptiMetrics Inc, DCS Co, 100 Walter Ward Blvd,Suite 100, Abingdon, MD 21009 USA.
[Stevenson, Shawn M.; Mantooth, Brent A.] US Army, Edgewood Chem Biol Ctr, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA.
RP Mantooth, BA (reprint author), US Army, Edgewood Chem Biol Ctr, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA.
EM brent.a.mantooth.civ@mail.mil
FU Defense Threat Reduction Agency (DTRA) [CB3062]
FX The authors thank Jerry Glasow, Eric Lowenstein, and Michael Roberts at
the Defense Threat Reduction Agency (DTRA) for funding this work under
program CB3062. The authors thank Janlyn Eikenberg, Janet Fouse,
Stefanie Smallwood, Nicholas Sapienza, and Amanda Schenning for their
support in performing the experiments and Michael Chesebrough for
performing the chromatography analysis. The contributions from M.J.V.
and T.P.P. were performed under contract at the Edgewood Chemical
Biological Center.
NR 44
TC 1
Z9 1
U1 6
U2 17
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0888-5885
J9 IND ENG CHEM RES
JI Ind. Eng. Chem. Res.
PD MAR 23
PY 2016
VL 55
IS 11
BP 3139
EP 3149
DI 10.1021/acs.iecr.5b04826
PG 11
WC Engineering, Chemical
SC Engineering
GA DH5TK
UT WOS:000372854600023
ER
PT J
AU Farmer, A
Wang, X
Ganesan, A
Deiss, RG
Agan, BK
O'Bryan, TA
Akers, K
Okulicz, JF
AF Farmer, Aaron
Wang, Xun
Ganesan, Anuradha
Deiss, Robert G.
Agan, Brian K.
O'Bryan, Thomas A.
Akers, Kevin
Okulicz, Jason F.
TI Factors associated with HIV viral load "blips" and the relationship
between self-reported adherence and efavirenz blood levels on blip
occurrence: a case-control study
SO AIDS RESEARCH AND THERAPY
LA English
DT Article
DE Self-reported adherence; Human immunodeficiency virus; Blips
ID ACTIVE ANTIRETROVIRAL THERAPY; SINGLE-TABLET REGIMEN; TRANSIENT VIREMIA;
INFECTED PATIENTS; CLINICAL-SIGNIFICANCE; INTERMITTENT VIREMIA;
DRUG-RESISTANCE; NATURAL-HISTORY; HAART; SUPPRESSION
AB Background: The uncertain etiology of HIV viral load (VL) blips may lead to increased use of clinical resources. We evaluated the association of self-reported adherence (SRA) and antiretroviral (ART) drug levels on blip occurrence in US Military HIV Natural History Study (NHS) participants who initiated the single-tablet regimen efavirenz/emtricitabine/tenofovir disoproxil fumarate (EFV/FTC/TDF).
Methods: ART-naive NHS participants started on EFV/FTC/TDF between 2006 and 2013 who achieved VL suppression (<50 copies/mL) within 12 months and had available SRA and stored plasma samples were included. Participants with viral blips were compared with those who maintained VL suppression without blips. Untimed EFV plasma levels were evaluated on consecutive blip and non-blip dates by high performance liquid chromatography, with a level >= 1 mcg/mL considered therapeutic. SRA was categorized as >= 85 or <85 %. Descriptive statistics were performed for baseline characteristics and univariate and multivariate Cox proportional hazard models were used to assess the relationship between covariates and blip occurrence.
Results: A total of 772 individuals met inclusion criteria, including 99 (13 %) blip and 673 (87 %) control participants. African-American was the predominant ethnicity and the mean age was 29 years for both groups. SRA >= 85 % was associated with therapeutic EFV levels at both blip and non-blip time points (P = 0.0026); however no association was observed between blips and SRA or EFV levels among cases. On univariate analysis of cases versus controls, blips were associated with higher mean pre-treatment VL (HR 1.45, 95 % CI 1.11-1.89) and pre-treatment CD4 count <350 cells/mu L (68.1 vs 49.7 %). Multivariate analysis also showed that blips were associated with a higher mean VL (HR 1.42, 95 % CI 1.08-1.88; P = 0.0123) and lower CD4 count at ART initiation, with CD4 >= 500 cells/mu L having a protective effect (HR 0.45, 95 % CI 0.22-0.95; P = 0.0365). No association was observed for demographic characteristics or SRA.
Conclusion: Blips are commonly encountered in the clinical management of HIV-infected patients. Although blip occurrence was not associated with SRA or EFV blood levels in our study, blips were associated with HIV-related factors of pre-ART high VL and low CD4 count. Additional studies are needed to determine the etiology of blips in HIV-infected patients.
C1 [Farmer, Aaron; O'Bryan, Thomas A.; Akers, Kevin; Okulicz, Jason F.] San Antonio Mil Med Ctr, Infect Dis Serv, 3551 Roger Brooke Dr, Ft Sam Houston, TX USA.
[Wang, Xun; Ganesan, Anuradha; Deiss, Robert G.; Agan, Brian K.; O'Bryan, Thomas A.; Okulicz, Jason F.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biostat, Infect Dis Clin Res Program, Bethesda, MD 20814 USA.
[Ganesan, Anuradha] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA.
[Deiss, Robert G.] Naval Med Ctr San Diego, Div Infect Dis, San Diego, CA USA.
[Akers, Kevin] US Army Inst Surg Res, Ft Sam Houston, TX USA.
[Wang, Xun; Ganesan, Anuradha; Deiss, Robert G.; Agan, Brian K.; O'Bryan, Thomas A.] Henry M Jackson Fdn Adv Mil Med Inc, Bethesda, MD USA.
RP Okulicz, JF (reprint author), San Antonio Mil Med Ctr, Infect Dis Serv, 3551 Roger Brooke Dr, Ft Sam Houston, TX USA.; Okulicz, JF (reprint author), Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biostat, Infect Dis Clin Res Program, Bethesda, MD 20814 USA.
EM Jason.f.okulicz.mil@mail.mil
OI Agan, Brian/0000-0002-5114-1669
FU Infectious Disease Clinical Research Program (IDCRP), a Department of
Defense (DoD) program through the Uniformed Services University of the
Health Sciences [IDCRP-000-03]; National Institute of Allergy and
Infectious Diseases, National Institutes of Health (NIH) [Y1-AI-5072]
FX The content of this publication is the sole responsibility of the
authors and does not necessarily reflect the views or policies of the
NIH or the Department of Health and Human Services, the DoD or the
Departments of the Army, Navy or Air Force. Mention of trade names,
commercial products, or organizations does not imply endorsement by the
US Government. Support for this work (IDCRP-000-03) was provided by the
Infectious Disease Clinical Research Program (IDCRP), a Department of
Defense (DoD) program executed through the Uniformed Services University
of the Health Sciences. This project has been funded in whole, or in
part, with federal funds from the National Institute of Allergy and
Infectious Diseases, National Institutes of Health (NIH), under
Inter-Agency Agreement Y1-AI-5072.
NR 35
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U1 2
U2 3
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1742-6405
J9 AIDS RES THER
JI Aids Res. Ther.
PD MAR 22
PY 2016
VL 13
AR 16
DI 10.1186/s12981-016-0100-4
PG 8
WC Infectious Diseases
SC Infectious Diseases
GA DH2CF
UT WOS:000372591100001
PM 27905999
ER
PT J
AU Hammamieh, R
Muhie, S
Borschel, R
Gautam, A
Miller, SA
Chakraborty, N
Jett, M
AF Hammamieh, Rasha
Muhie, Seid
Borschel, Richard
Gautam, Aarti
Miller, Stacy-Ann
Chakraborty, Nabarun
Jett, Marti
TI Temporal Progression of Pneumonic Plague in Blood of Nonhuman Primate: A
Transcriptomic Analysis
SO PLOS ONE
LA English
DT Article
ID YERSINIA-PESTIS CO92; TOLL-LIKE RECEPTORS; MOUSE MODEL; KAPPA-B;
BIOLOGICAL AGENTS; IMMUNE-RESPONSE; INNATE IMMUNITY; BUBONIC PLAGUE;
INFECTION; EXPRESSION
AB Early identification of impending illness during widespread exposure to a pathogenic agent offers a potential means to initiate treatment during a timeframe when it would be most likely to be effective and has the potential to identify novel therapeutic strategies. The latter could be critical, especially as antibiotic resistance is becoming widespread. In order to examine pre-symptomatic illness, African green monkeys were challenged intranasally with aerosolized Yersinia pestis strain CO92 and blood samples were collected in short intervals from 45 m till 42 h post-exposure. Presenting one of the first genomic investigations of a NHP model challenged by pneumonic plague, whole genome analysis was annotated in silico and validated by qPCR assay. Transcriptomic profiles of blood showed early perturbation with the number of differentially expressed genes increasing until 24 h. By then, Y. pestis had paralyzed the host defense, as suggested by the functional analyses. Early activation of the apoptotic networks possibly facilitated the pathogen to overwhelm the defense mechanisms, despite the activation of the pro-inflammatory mechanism, toll-like receptors and microtubules at the port-of-entry. The overexpressed transcripts encoding an early pro-inflammatory response particularly manifested in active lymphocytes and ubiquitin networks were a potential deviation from the rodent models, which needs further verification. In summary, the present study recognized a pattern of Y. pestis pathogenesis potentially more applicable to the human system. Independent validation using the complementary omics approach with comprehensive evaluation of the organs, such as lungs which showed early bacterial infection, is essential.
C1 [Hammamieh, Rasha; Muhie, Seid; Gautam, Aarti; Miller, Stacy-Ann; Chakraborty, Nabarun; Jett, Marti] US Army Ctr Environm Hlth Res, Ft Detrick, MD 21702 USA.
[Muhie, Seid] NCI, Adv Biomed Ctr, Fredrick Natl Lab Canc Res, Frederick, MD 21702 USA.
[Borschel, Richard] Walter Reed Army Med Ctr, Silver Spring, MD 20910 USA.
[Gautam, Aarti; Miller, Stacy-Ann; Chakraborty, Nabarun] Geneva Fdn, Ft Detrick, MD 21702 USA.
RP Hammamieh, R (reprint author), US Army Ctr Environm Hlth Res, Ft Detrick, MD 21702 USA.
EM Rasha.Hammamieh1.civ@mail.mil
FU Defense Threat Reduction Agency [TMTI0029_09_WR_T]
FX This work was supported by Defense Threat Reduction Agency, Funding #:
TMTI0029_09_WR_T received by: MJ and RH.
NR 59
TC 1
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U1 3
U2 6
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 22
PY 2016
VL 11
IS 3
AR e0151788
DI 10.1371/journal.pone.0151788
PG 21
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DH3OX
UT WOS:000372697400043
PM 27003632
ER
PT J
AU Sellers, MS
Lisal, M
Brennan, JK
AF Sellers, Michael S.
Lisal, Martin
Brennan, John K.
TI Free-energy calculations using classical molecular simulation:
application to the determination of the melting point and chemical
potential of a flexible RDX model
SO PHYSICAL CHEMISTRY CHEMICAL PHYSICS
LA English
DT Article
ID SOLID-LIQUID COEXISTENCE; ATOMISTIC SIMULATION; DYNAMICS SIMULATIONS;
COMPUTER-SIMULATION; PHASE COEXISTENCE; FLUID MIXTURES; IONIC LIQUIDS;
HARD-SPHERES; FORCE-FIELD; INTEGRATION
AB We present an extension of various free-energy methodologies to determine the chemical potential of the solid and liquid phases of a fully-flexible molecule using classical simulation. The methods are applied to the Smith-Bharadwaj atomistic potential representation of cyclotrimethylene trinitramine (RDX), a well-studied energetic material, to accurately determine the solid and liquid phase Gibbs free energies, and the melting point (T-m). We outline an efficient technique to find the absolute chemical potential and melting point of a fully-flexible molecule using one set of simulations to compute the solid absolute chemical potential and one set of simulations to compute the solid-liquid free energy difference. With this combination, only a handful of simulations are needed, whereby the absolute quantities of the chemical potentials are obtained, for use in other property calculations, such as the characterization of crystal polymorphs or the determination of the entropy. Using the LAMMPS molecular simulator, the Frenkel and Ladd and pseudo-supercritical path techniques are adapted to generate 3rd order fits of the solid and liquid chemical potentials. Results yield the thermodynamic melting point T-m = 488.75 K at 1.0 atm. We also validate these calculations and compare this melting point to one obtained from a typical superheated simulation technique.
C1 [Sellers, Michael S.; Brennan, John K.] US Army, Res Lab, Weap & Mat Res Directorate, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA.
[Lisal, Martin] ASCR, Lab Chem & Phys Aerosols, Inst Chem Proc Fundamentals, Vvi, Rozvojova 135-1, Prague 16502 6, Suchdol, Czech Republic.
[Lisal, Martin] Univ JE Purkyne, Dept Phys, Fac Sci, Ceske Mladeze 8, Usti Nad Labem 40096, Czech Republic.
RP Brennan, JK (reprint author), US Army, Res Lab, Weap & Mat Res Directorate, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA.
EM john.k.brennan.civ@mail.mil
RI Lisal, Martin/A-8176-2011
OI Lisal, Martin/0000-0001-8005-7143
FU ARL [W911NF-10-2-0039]; Czech Science Foundation [13-02938S]; U.S. Army
Research Laboratory
FX The authors are grateful to Brian C. Barnes, Joshua D. Moore, Sergey
Izvekov, James P. Larentzos, and Betsy M. Rice (U.S. Army Research
Laboratory) for insightful discussions. The authors also acknowledge the
computational resources and PETTT software support from the Department
of Defense High Performance Computing Modernization Program (HPCMP). ML
acknowledges sponsorship by the ARL under Cooperative Agreement
W911NF-10-2-0039, and the Czech Science Foundation under project:
13-02938S. MSS acknowledges funding through a contract appointment at
the U.S. Army Research Laboratory, administered by the Oak Ridge
Institute for Science and Education through an interagency agreement
between the U.S. Department of Energy and U.S. Army Research Laboratory.
NR 47
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Z9 0
U1 8
U2 26
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 1463-9076
EI 1463-9084
J9 PHYS CHEM CHEM PHYS
JI Phys. Chem. Chem. Phys.
PD MAR 21
PY 2016
VL 18
IS 11
BP 7841
EP 7850
DI 10.1039/c5cp06164d
PG 10
WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical
SC Chemistry; Physics
GA DG6XP
UT WOS:000372229700028
PM 26661376
ER
PT J
AU Lum, JS
Salinas, SS
Filocamo, SF
AF Lum, June S.
Salinas, Stephen S.
Filocamo, Shaun F.
TI Multifunctional coatings created using an antimicrobial polymer as a
platform for titania precipitation on cotton
SO JOURNAL OF APPLIED POLYMER SCIENCE
LA English
DT Article
DE biomaterials; coatings; textiles
ID DIISOPROPYL FLUOROPHOSPHATASE; LOLIGO-VULGARIS; FABRICS; MECHANISM;
NANOCOMPOSITES; ENCAPSULATION; PERFORMANCE; TEXTILES; BINDING; PROTEIN
AB Titania precipitation on cotton has been achieved using a commercially available antimicrobial polymer, Reputex 20. The cotton swatches precipitated with titania retain antimicrobial activity, and we have also shown the ability to encapsulate diisopropyl-fluorophosphatase (DFPase), an enzyme capable of breaking down organofluorophosphates. Cotton swatches are easily prepared and precipitation occurs at room temperature in aqueous solutions at neutral pH. Both the antimicrobial properties of Reputex 20 and the hydrolytic activity of the DFPase enzyme are retained after titania precipitation, generating a cotton material exhibiting multifunctional properties. (C) 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43199.
C1 [Lum, June S.; Salinas, Stephen S.; Filocamo, Shaun F.] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA.
[Salinas, Stephen S.] MIT, Cambridge, MA 02139 USA.
RP Filocamo, SF (reprint author), US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA.
EM shaun.f.filocamo.civ@mail.mil
FU United States Army
FX This work was supported by the United States Army. This research was
supported in part by an appointment of J.S.L. to the Postgraduate
Research Participation Program at the U.S. Army Natick Soldier Research,
Development and Engineering Center administered by the Oak Ridge
Institute for Science and Education through an interagency agreement
between the U.S. Department of Energy and NSRDEC. The authors would like
to thank David Ziegler for assistance with the SEM and XRD facilities at
NSRDEC. Robert E. Stote II is acknowledged for helpful discussions
regarding antimicrobial activity. Robert Guarino from Lonza is
gratefully acknowledged for the generous donation of Reputex 20
solution.
NR 40
TC 0
Z9 0
U1 6
U2 20
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-8995
EI 1097-4628
J9 J APPL POLYM SCI
JI J. Appl. Polym. Sci.
PD MAR 20
PY 2016
VL 133
IS 12
AR 43199
DI 10.1002/APP.43199
PG 12
WC Polymer Science
SC Polymer Science
GA DA6KP
UT WOS:000367913500012
ER
PT J
AU Corti, D
Misasi, J
Mulangu, S
Stanley, DA
Kanekiyo, M
Wollen, S
Ploquin, A
Doria-Rose, NA
Staupe, RP
Bailey, M
Shi, W
Choe, M
Marcus, H
Thompson, EA
Cagigi, A
Silacci, C
Fernandez-Rodriguez, B
Perez, L
Sallusto, F
Vanzetta, F
Agatic, G
Cameroni, E
Kisalu, N
Gordon, I
Ledgerwood, JE
Mascola, JR
Graham, BS
Muyembe-Tamfun, JJ
Trefry, JC
Lanzavecchia, A
Sullivan, NJ
AF Corti, Davide
Misasi, John
Mulangu, Sabue
Stanley, Daphne A.
Kanekiyo, Masaru
Wollen, Suzanne
Ploquin, Aurelie
Doria-Rose, Nicole A.
Staupe, Ryan P.
Bailey, Michael
Shi, Wei
Choe, Misook
Marcus, Hadar
Thompson, Emily A.
Cagigi, Alberto
Silacci, Chiara
Fernandez-Rodriguez, Blanca
Perez, Laurent
Sallusto, Federica
Vanzetta, Fabrizia
Agatic, Gloria
Cameroni, Elisabetta
Kisalu, Neville
Gordon, Ingelise
Ledgerwood, Julie E.
Mascola, John R.
Graham, Barney S.
Muyembe-Tamfun, Jean-Jacques
Trefry, John C.
Lanzavecchia, Antonio
Sullivan, Nancy J.
TI Protective monotherapy against lethal Ebola virus infection by a
potently neutralizing antibody
SO SCIENCE
LA English
DT Article
ID MONOCLONAL-ANTIBODIES; OUTBREAK; MONKEYS; DISEASE; ZAIRE
AB Ebola virus disease in humans is highly lethal, with case fatality rates ranging from 25 to 90%. There is no licensed treatment or vaccine against the virus, underscoring the need for efficacious countermeasures. We ascertained that a human survivor of the 1995 Kikwit Ebola virus disease outbreak maintained circulating antibodies against the Ebola virus surface glycoprotein for more than a decade after infection. From this survivor we isolated monoclonal antibodies (mAbs) that neutralize recent and previous outbreak variants of Ebola virus and mediate antibody-dependent cell-mediated cytotoxicity in vitro. Strikingly, monotherapy with mAb114 protected macaques when given as late as 5 days after challenge. Treatment with a single human mAb suggests that a simplified therapeutic strategy for human Ebola infection may be possible.
C1 [Corti, Davide; Silacci, Chiara; Fernandez-Rodriguez, Blanca; Perez, Laurent; Sallusto, Federica; Lanzavecchia, Antonio] Univ Svizzera Italiana, Inst Res Biomed, CH-6500 Bellinzona, Switzerland.
[Corti, Davide; Vanzetta, Fabrizia; Agatic, Gloria; Cameroni, Elisabetta] Humabs BioMed SA, CH-6500 Bellinzona, Switzerland.
[Misasi, John; Mulangu, Sabue; Stanley, Daphne A.; Kanekiyo, Masaru; Ploquin, Aurelie; Doria-Rose, Nicole A.; Staupe, Ryan P.; Bailey, Michael; Shi, Wei; Choe, Misook; Marcus, Hadar; Thompson, Emily A.; Cagigi, Alberto; Kisalu, Neville; Gordon, Ingelise; Ledgerwood, Julie E.; Mascola, John R.; Graham, Barney S.; Sullivan, Nancy J.] NIAID, Vaccine Res Ctr, 9000 Rockville Pike, Bethesda, MD 20892 USA.
[Wollen, Suzanne; Trefry, John C.] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
[Kisalu, Neville; Muyembe-Tamfun, Jean-Jacques] Natl Lab Publ Hlth, Natl Inst Biomed Res, BP 1197, Kinshasa, DEM REP CONGO.
[Lanzavecchia, Antonio] ETH, Inst Microbiol, CH-8093 Zurich, Switzerland.
RP Sullivan, NJ (reprint author), NIAID, Vaccine Res Ctr, 9000 Rockville Pike, Bethesda, MD 20892 USA.
EM njsull@mail.nih.gov
RI Cagigi, Alberto/K-4824-2016
OI Cagigi, Alberto/0000-0002-3567-9514
FU Intramural Research Program of the Vaccine Research Center, National
Institute of Allergy and Infectious Diseases
FX We thank M. Cichanowski for graphics, B. Hartman for manuscript
preparation, A. Tislerics and J. McLellan for critical reading of the
manuscript, A. R. Townsend for providing EBOV-GP expressing MDCK-SIAT
cells, and the study volunteers for the donation of blood for these
investigations. The data reported in this manuscript are tabulated in
the main paper and in the supplementary materials. Antibody sequences
have been deposited in GenBank with accession numbers KU594601,
KU594602, KU594603, and KU594604. Supported by the Intramural Research
Program of the Vaccine Research Center, National Institute of Allergy
and Infectious Diseases. N.J.S., S.M., B.S.G., J.E.L, D.A.S., J.-J.M.-T
J.C.T., D.C., and A.L. are listed as inventors on patent applications
related to anti-Ebola virus antibodies and their use. Opinions,
interpretations, conclusions, and recommendations are those of the
authors and are not necessarily endorsed by the U.S. Department of
Defense or the U.S. Department of the Army.
NR 19
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U1 12
U2 30
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 0036-8075
EI 1095-9203
J9 SCIENCE
JI Science
PD MAR 18
PY 2016
VL 351
IS 6279
BP 1339
EP 1342
DI 10.1126/science.aad5224
PG 4
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DG9JD
UT WOS:000372397700047
PM 26917593
ER
PT J
AU Bucher, B
Zhu, S
Wu, CY
Janssens, RVF
Cline, D
Hayes, AB
Albers, M
Ayangeakaa, AD
Butler, PA
Campbell, CM
Carpenter, MP
Chiara, CJ
Clark, JA
Crawford, HL
Cromaz, M
David, HM
Dickerson, C
Gregor, ET
Harker, J
Hoffman, CR
Kay, BP
Kondev, FG
Korichi, A
Lauritsen, T
Macchiavelli, AO
Pardo, RC
Richard, A
Riley, MA
Savard, G
Scheck, M
Seweryniak, D
Smith, MK
Vondrasek, R
Wiens, A
AF Bucher, B.
Zhu, S.
Wu, C. Y.
Janssens, R. V. F.
Cline, D.
Hayes, A. B.
Albers, M.
Ayangeakaa, A. D.
Butler, P. A.
Campbell, C. M.
Carpenter, M. P.
Chiara, C. J.
Clark, J. A.
Crawford, H. L.
Cromaz, M.
David, H. M.
Dickerson, C.
Gregor, E. T.
Harker, J.
Hoffman, C. R.
Kay, B. P.
Kondev, F. G.
Korichi, A.
Lauritsen, T.
Macchiavelli, A. O.
Pardo, R. C.
Richard, A.
Riley, M. A.
Savard, G.
Scheck, M.
Seweryniak, D.
Smith, M. K.
Vondrasek, R.
Wiens, A.
TI Direct Evidence of Octupole Deformation in Neutron-Rich Ba-144
SO PHYSICAL REVIEW LETTERS
LA English
DT Article
ID GROUND-STATE; BARIUM ISOTOPES; RADIOACTIVE BEAMS; DEFORMED-NUCLEI;
PARITY; ENERGY
AB The neutron-rich nucleus Ba-144 (t(1/2) = 11.5 s) is expected to exhibit some of the strongest octupole correlations among nuclei with mass numbers A less than 200. Until now, indirect evidence for such strong correlations has been inferred from observations such as enhanced E1 transitions and interleaving positive- and negative-parity levels in the ground-state band. In this experiment, the octupole strength was measured directly by sub-barrier, multistep Coulomb excitation of a post-accelerated 650-MeV Ba-144 beam on a 1.0-mg/cm(2) Pb-208 target. The measured value of the matrix element, < 3(1)(-)parallel to M(E3)parallel to 0(1)(+)> = 0.65((+17)(-23)) eb(3/2,) corresponds to a reduced Bd(E3) transition probability of 48((+25)(-34)) W.u. This result represents an unambiguous determination of the octupole collectivity, is larger than any available theoretical prediction, and is consistent with octupole deformation.
C1 [Bucher, B.; Wu, C. Y.] Lawrence Livermore Natl Lab, Livermore, CA 94550 USA.
[Zhu, S.; Janssens, R. V. F.; Albers, M.; Ayangeakaa, A. D.; Carpenter, M. P.; Chiara, C. J.; Clark, J. A.; David, H. M.; Dickerson, C.; Harker, J.; Hoffman, C. R.; Kay, B. P.; Kondev, F. G.; Korichi, A.; Lauritsen, T.; Pardo, R. C.; Savard, G.; Seweryniak, D.; Vondrasek, R.] Argonne Natl Lab, 9700 S Cass Ave, Argonne, IL 60439 USA.
[Cline, D.; Hayes, A. B.] Univ Rochester, 601 Elmwood Ave, Rochester, NY 14627 USA.
[Butler, P. A.] Univ Liverpool, Liverpool L69 7ZE, Merseyside, England.
[Campbell, C. M.; Crawford, H. L.; Cromaz, M.; Macchiavelli, A. O.; Wiens, A.] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA.
[Chiara, C. J.; Harker, J.] Univ Maryland, College Pk, MD 20742 USA.
[Crawford, H. L.; Richard, A.] Ohio Univ, Athens, OH 45701 USA.
[Gregor, E. T.; Scheck, M.] Univ West Scotland, Paisley PA1 2BE, Renfrew, Scotland.
[Gregor, E. T.; Scheck, M.] SUPA, Glasgow G12 8QQ, Lanark, Scotland.
[Korichi, A.] IN2P3 CNRS, CSNSM, Batiment 104-108, F-91405 Orsay, France.
[Riley, M. A.] Florida State Univ, Tallahassee, FL 32306 USA.
[Smith, M. K.] Univ Notre Dame, Notre Dame, IN 46556 USA.
[Chiara, C. J.] US Army Res Lab, Adelphi, MD 20783 USA.
[David, H. M.] GSI Helmholtzzentrum Schwerionenforsch, D-64291 Darmstadt, Germany.
RP Bucher, B (reprint author), Lawrence Livermore Natl Lab, Livermore, CA 94550 USA.
EM bucher3@llnl.gov
RI Hoffman, Calem/H-4325-2016; Kay, Benjamin/F-3291-2011
OI Hoffman, Calem/0000-0001-7141-9827; Kay, Benjamin/0000-0002-7438-0208
FU U.S. Department of Energy, Office of Science, Office of Nuclear Physics
[DE-AC02-06CH11357, DE-AC02-05CH11231, DE-AC52-07NA27344]; DOE
[DE-FG02-94ER40834]; National Science Foundation [PHY-01401574,
PHY-1068192]; STFC (UK) [ST/L005808/1]
FX This work was funded by the U.S. Department of Energy, Office of
Science, Office of Nuclear Physics, under Contract No. DE-AC02-06CH11357
(ANL), No. DE-AC02-05CH11231 (LBNL, GRETINA), No. DE-AC52-07NA27344
(LLNL), DOE Grant No. DE-FG02-94ER40834 (UM), and the National Science
Foundation Grant No. PHY-01401574 (FSU) and PHY-1068192 (ND). M. S. and
E. T. G. were supported by STFC (UK) Grant No. ST/L005808/1. This
research used resources of ANL's ATLAS facility, which is a DOE Office
of Science User Facility.
NR 29
TC 11
Z9 11
U1 2
U2 8
PU AMER PHYSICAL SOC
PI COLLEGE PK
PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA
SN 0031-9007
EI 1079-7114
J9 PHYS REV LETT
JI Phys. Rev. Lett.
PD MAR 17
PY 2016
VL 116
IS 11
AR 112503
DI 10.1103/PhysRevLett.116.112503
PG 5
WC Physics, Multidisciplinary
SC Physics
GA DG9VU
UT WOS:000372432700004
PM 27035298
ER
PT J
AU Warren, TK
Jordan, R
Lo, MK
Ray, AS
Mackman, RL
Soloveva, V
Siegel, D
Perron, M
Bannister, R
Hui, HC
Larson, N
Strickley, R
Wells, J
Stuthman, KS
Van Tongeren, SA
Garza, NL
Donnelly, G
Shurtleff, AC
Retterer, CJ
Gharaibeh, D
Zamani, R
Kenny, T
Eaton, BP
Grimes, E
Welch, LS
Gomba, L
Wilhelmsen, CL
Nichols, DK
Nuss, JE
Nagle, ER
Kugelman, JR
Palacios, G
Doerffler, E
Neville, S
Carra, E
Clarke, MO
Zhang, LJ
Lew, W
Ross, B
Wang, Q
Chun, K
Wolfe, L
Babusis, D
Park, Y
Stray, KM
Trancheva, I
Feng, JY
Barauskas, O
Xu, YL
Wong, P
Braun, MR
Flint, M
McMullan, LK
Chen, SS
Fearns, R
Swaminathan, S
Mayers, DL
Spiropoulou, CF
Lee, WA
Nichol, ST
Cihlar, T
Bavari, S
AF Warren, Travis K.
Jordan, Robert
Lo, Michael K.
Ray, Adrian S.
Mackman, Richard L.
Soloveva, Veronica
Siegel, Dustin
Perron, Michel
Bannister, Roy
Hui, Hon C.
Larson, Nate
Strickley, Robert
Wells, Jay
Stuthman, Kelly S.
Van Tongeren, Sean A.
Garza, Nicole L.
Donnelly, Ginger
Shurtleff, Amy C.
Retterer, Cary J.
Gharaibeh, Dima
Zamani, Rouzbeh
Kenny, Tara
Eaton, Brett P.
Grimes, Elizabeth
Welch, Lisa S.
Gomba, Laura
Wilhelmsen, Catherine L.
Nichols, Donald K.
Nuss, Jonathan E.
Nagle, Elyse R.
Kugelman, Jeffrey R.
Palacios, Gustavo
Doerffler, Edward
Neville, Sean
Carra, Ernest
Clarke, Michael O.
Zhang, Lijun
Lew, Willard
Ross, Bruce
Wang, Queenie
Chun, Kwon
Wolfe, Lydia
Babusis, Darius
Park, Yeojin
Stray, Kirsten M.
Trancheva, Iva
Feng, Joy Y.
Barauskas, Ona
Xu, Yili
Wong, Pamela
Braun, Molly R.
Flint, Mike
McMullan, Laura K.
Chen, Shan-Shan
Fearns, Rachel
Swaminathan, Swami
Mayers, Douglas L.
Spiropoulou, Christina F.
Lee, William A.
Nichol, Stuart T.
Cihlar, Tomas
Bavari, Sina
TI Therapeutic efficacy of the small molecule GS-5734 against Ebola virus
in rhesus monkeys
SO NATURE
LA English
DT Article
ID INFECTED NONHUMAN-PRIMATES; ANTIVIRAL ACTIVITY; T-705 FAVIPIRAVIR;
HIGH-THROUGHPUT; POLYMERASE; INHIBITOR; MODEL; PROTECTION; MACAQUES;
PROMOTER
AB The most recent Ebola virus outbreak in West Africa, which was unprecedented in the number of cases and fatalities, geographic distribution, and number of nations affected, highlights the need for safe, effective, and readily available antiviral agents for treatment and prevention of acute Ebola virus (EBOV) disease (EVD) or sequelae(1). No antiviral therapeutics have yet received regulatory approval or demonstrated clinical efficacy. Here we report the discovery of a novel small molecule GS-5734, a monophosphoramidate prodrug of an adenosine analogue, with antiviral activity against EBOV. GS-5734 exhibits antiviral activity against multiple variants of EBOV and other filoviruses in cell-based assays. The pharmacologically active nucleoside triphosphate (NTP) is efficiently formed in multiple human cell types incubated with GS-5734 in vitro, and the NTP acts as an alternative substrate and RNA-chain terminator in primer-extension assays using a surrogate respiratory syncytial virus RNA polymerase. Intravenous administration of GS-5734 to nonhuman primates resulted in persistent NTP levels in peripheral blood mononuclear cells (half-life, 14 h) and distribution to sanctuary sites for viral replication including testes, eyes, and brain. In a rhesus monkey model of EVD, once-daily intravenous administration of 10 mg kg(-1) GS-5734 for 12 days resulted in profound suppression of EBOV replication and protected 100% of EBOV-infected animals against lethal disease, ameliorating clinical disease signs and pathophysiological markers, even when treatments were initiated three days after virus exposure when systemic viral RNA was detected in two out of six treated animals. These results show the first substantive post-exposure protection by a small-molecule antiviral compound against EBOV in nonhuman primates. The broad-spectrum antiviral activity of GS-5734 in vitro against other pathogenic RNA viruses, including filoviruses, arenaviruses, and coronaviruses, suggests the potential for wider medical use. GS-5734 is amenable to large-scale manufacturing, and clinical studies investigating the drug safety and pharmacokinetics are ongoing.
C1 [Warren, Travis K.; Soloveva, Veronica; Wells, Jay; Stuthman, Kelly S.; Van Tongeren, Sean A.; Garza, Nicole L.; Donnelly, Ginger; Shurtleff, Amy C.; Retterer, Cary J.; Gharaibeh, Dima; Zamani, Rouzbeh; Kenny, Tara; Eaton, Brett P.; Grimes, Elizabeth; Welch, Lisa S.; Gomba, Laura; Wilhelmsen, Catherine L.; Nichols, Donald K.; Nuss, Jonathan E.; Nagle, Elyse R.; Kugelman, Jeffrey R.; Palacios, Gustavo; Mayers, Douglas L.; Bavari, Sina] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
[Warren, Travis K.; Soloveva, Veronica; Gomba, Laura; Nuss, Jonathan E.; Bavari, Sina] US Army, Med Res Inst Infect Dis, Therapeut Dev Ctr, Ft Detrick, MD 21702 USA.
[Jordan, Robert; Ray, Adrian S.; Mackman, Richard L.; Siegel, Dustin; Perron, Michel; Bannister, Roy; Hui, Hon C.; Larson, Nate; Strickley, Robert; Doerffler, Edward; Neville, Sean; Carra, Ernest; Clarke, Michael O.; Zhang, Lijun; Lew, Willard; Ross, Bruce; Wang, Queenie; Chun, Kwon; Wolfe, Lydia; Babusis, Darius; Park, Yeojin; Stray, Kirsten M.; Trancheva, Iva; Feng, Joy Y.; Barauskas, Ona; Xu, Yili; Wong, Pamela; Chen, Shan-Shan; Swaminathan, Swami; Lee, William A.; Cihlar, Tomas] Gilead Sci Inc, 353 Lakeside Dr, Foster City, CA 94404 USA.
[Lo, Michael K.; Flint, Mike; McMullan, Laura K.; Spiropoulou, Christina F.; Nichol, Stuart T.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
[Braun, Molly R.; Fearns, Rachel] Boston Univ, Sch Med, Boston, MA 02118 USA.
[Welch, Lisa S.] LOKET Consulting, Clarksburg, MD 20871 USA.
[Mayers, Douglas L.] Cocrystal Pharma, Tucker, GA 30084 USA.
RP Bavari, S (reprint author), US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.; Bavari, S (reprint author), US Army, Med Res Inst Infect Dis, Therapeut Dev Ctr, Ft Detrick, MD 21702 USA.; Cihlar, T (reprint author), Gilead Sci Inc, 353 Lakeside Dr, Foster City, CA 94404 USA.
EM tomas.cihlar@gilead.com; sina.bavari.civ@mail.mil
OI Palacios, Gustavo/0000-0001-5062-1938
FU Joint Science and Technology Office for Chemical and Biological Defense
(JSTO-CBD) of the Defense Threat Reduction Agency (DTRA) [CB10218]; NIH
[R01AI113321]
FX T. Bocan, A. Duplantier, R. Panchal, and C. Kane provided scientific
input. B. Norquist assisted with manuscript preparation. C. Cooper
provided scientific input with human macrophage cultures for
high-content image assessments. S. Tritsch and G. Gomba assisted with
GS-5734 dose preparations for efficacy studies. C. Rice provided animal
husbandry support services. X. Wei, W. Garner, and L. Zhong provided
additional support for statistical analyses. K. Wang, K. Brendza, T.
Alfredson, and L. Serafini assisted with analytical methods; S. Bondy
and R. Seemayer procured key raw materials; L. Heumann, R. Polniaszeck,
E. Rueden, A. Chtchemelinine, K. Brak, and B. Hoang contributed to
synthesis; and Y. Zherebina helped with chiral separations. G. Lee
supported the RSV antiviral assay, and G. Stepan, S. Ahmadyar, and H. Yu
conducted part of the cytotoxicity testing. J. Knox contributed to
polymerase modelling. A. L. Rheingold performed the X-ray
crystallographic analysis (Supplementary Information). Studies at
USAMRIID were in part supported by The Joint Science and Technology
Office for Chemical and Biological Defense (JSTO-CBD) of the Defense
Threat Reduction Agency (DTRA) under plan #CB10218. Work in the Fearns
laboratory was supported by NIH R01AI113321. Opinions, interpretations,
conclusions, and recommendations are those of the authors and are not
necessarily endorsed by the US Army or the Centers for Disease Control
and Prevention, US Department of Health and Human Services.
NR 37
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U1 10
U2 29
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0028-0836
EI 1476-4687
J9 NATURE
JI Nature
PD MAR 17
PY 2016
VL 531
IS 7594
BP 381
EP +
DI 10.1038/nature17180
PG 19
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DG4TA
UT WOS:000372064300055
PM 26934220
ER
PT J
AU Owolabi, G
Peterson, A
Habtour, E
Riddick, J
Coatney, M
Olasumboye, A
Bolling, D
AF Owolabi, Gbadebo
Peterson, Alex
Habtour, Ed
Riddick, Jaret
Coatney, Michael
Olasumboye, Adewale
Bolling, Denzell
TI Dynamic response of acrylonitrile butadiene styrene under impact loading
SO INTERNATIONAL JOURNAL OF MECHANICAL AND MATERIALS ENGINEERING
LA English
DT Article
DE Additive manufacturing; Acrylonitrile butadiene styrene; High strain
rates; Dynamic response
ID HIGH-STRAIN RATE; PLASTIC-DEFORMATION; TI-6AL-4V ALLOY; BEHAVIOR; RATES;
POLYMERS; FAILURE; DESIGN
AB Background: The goal of the study is to understand the potential energy absorption benefits ofcomponents fabricated using fused deposition modeling additive manufacturing under high strain rateloading.
Methods: Tensile tests were conducted on 3-D printed acrylonitrile butadiene styrene (ABS) at differentstrain rates, according to the ASTM D638 standard, to assess its strain rate sensitivity under quasi-staticloads. The tensile test was also necessary to determine the mechanical properties necessary to characterizethe dynamic response of the ABS at high strain rates. The ABS specimens were subjected to high strainrate deformation through the use of the split Hopkinson pressure bar.
Results: During compression, a new phenomenon described as a multistage collapse in which the samplesundergo multiple stages of contraction and expansion was observed as the impact load was applied. Thismultistage deformation behavior may be attributable to the ring formed around layers in the specimen dueto the manner of fabrication which potentially absorbed and released the energy, thus acting as a multistage spring. As the velocity of impact increases, it is observed that the ABS capability for energy absorption decreased to where there was only one stage of compression equivalent to the initial stage.
Conclusion: The multistage collapse of the 3-D printed ABS specimen indicates a potential for a novel energy absorption mechanism to be exploited at lower strain rates. Future work in the area should include more studies about printing orientation, as well as investigating the impact of the presence of the outer cylindrical ring on the overall dynamic response.
C1 [Owolabi, Gbadebo; Peterson, Alex; Olasumboye, Adewale; Bolling, Denzell] Howard Univ, Dept Mech Engn, Washington, DC 20059 USA.
[Habtour, Ed; Riddick, Jaret; Coatney, Michael] US Army, Res Lab, Vehicle Technol Directorate, Aberdeen, MD USA.
RP Owolabi, G (reprint author), Howard Univ, Dept Mech Engn, Washington, DC 20059 USA.
EM gbadebo.owolabi@howard.edu
NR 19
TC 1
Z9 1
U1 2
U2 4
PU SPRINGER SINGAPORE PTE LTD
PI SINGAPORE
PA #04-01 CENCON I, 1 TANNERY RD, SINGAPORE 347719, SINGAPORE
SN 1823-0334
EI 2198-2791
J9 INT J MECH MATER ENG
JI Int. J. Mech. Mater. Eng.
PD MAR 16
PY 2016
VL 11
AR 3
DI 10.1186/s40712-016-0056-0
PG 8
WC Materials Science, Multidisciplinary
SC Materials Science
GA DO7QV
UT WOS:000377978200001
ER
PT J
AU Goldschmidt, EA
Boulier, T
Brown, RC
Koller, SB
Young, JT
Gorshkov, AV
Rolston, SL
Porto, JV
AF Goldschmidt, E. A.
Boulier, T.
Brown, R. C.
Koller, S. B.
Young, J. T.
Gorshkov, A. V.
Rolston, S. L.
Porto, J. V.
TI Anomalous Broadening in Driven Dissipative Rydberg Systems
SO PHYSICAL REVIEW LETTERS
LA English
DT Article
ID ATOMS
AB We observe interaction-induced broadening of the two-photon 5s-18s transition in Rb-87 atoms trapped in a 3D optical lattice. The measured linewidth increases by nearly 2 orders of magnitude with increasing atomic density and excitation strength, with corresponding suppression of resonant scattering and enhancement of off-resonant scattering. We attribute the increased linewidth to resonant dipole-dipole interactions of 18s atoms with blackbody induced population in nearby np states. Over a range of initial atomic densities and excitation strengths, the transition width is described by a single function of the steady-state density of Rydberg atoms, and the observed resonant excitation rate corresponds to that of a two-level system with the measured, rather than natural, linewidth. The broadening mechanism observed here is likely to have negative implications for many proposals with coherently interacting Rydberg atoms.
C1 [Goldschmidt, E. A.] US Army Res Lab, Adelphi, MD 20783 USA.
[Boulier, T.; Brown, R. C.; Koller, S. B.; Young, J. T.; Gorshkov, A. V.; Rolston, S. L.; Porto, J. V.] NIST, Joint Quantum Inst, Gaithersburg, MD 20899 USA.
[Boulier, T.; Brown, R. C.; Koller, S. B.; Young, J. T.; Gorshkov, A. V.; Rolston, S. L.; Porto, J. V.] Univ Maryland, Gaithersburg, MD 20899 USA.
[Gorshkov, A. V.] NIST, Joint Ctr Quantum Informat & Comp Sci, College Pk, MD 20742 USA.
[Gorshkov, A. V.] Univ Maryland, College Pk, MD 20742 USA.
[Brown, R. C.] NIST, Boulder, CO 80305 USA.
[Koller, S. B.] Phys Tech Bundesanstalt, D-38116 Braunschweig, Germany.
RP Porto, JV (reprint author), NIST, Joint Quantum Inst, Gaithersburg, MD 20899 USA.; Porto, JV (reprint author), Univ Maryland, Gaithersburg, MD 20899 USA.
EM porto@umd.edu
RI Brown, Roger/A-9630-2009; Gorshkov, Alexey/A-9848-2008; rolston,
steven/L-5175-2013;
OI Brown, Roger/0000-0002-8228-4283; Gorshkov, Alexey/0000-0003-0509-3421;
rolston, steven/0000-0003-1671-4190; Goldschmidt,
Elizabeth/0000-0002-6553-9731
FU NSF PIF; AFOSR; ARO; ARL-CDQI; NSF PFC at JQI
FX The authors thank T. C. Killian, F. B. Dunning, A. Browaeys, M.
Foss-Feig, A. Hu, R. M. Wilson, and Z. X. Gong for helpful discussions.
This work was partially supported by NSF PIF, AFOSR, ARO, ARL-CDQI, and
NSF PFC at JQI.
NR 40
TC 15
Z9 15
U1 1
U2 5
PU AMER PHYSICAL SOC
PI COLLEGE PK
PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA
SN 0031-9007
EI 1079-7114
J9 PHYS REV LETT
JI Phys. Rev. Lett.
PD MAR 16
PY 2016
VL 116
IS 11
AR 113001
DI 10.1103/PhysRevLett.116.113001
PG 5
WC Physics, Multidisciplinary
SC Physics
GA DG9VQ
UT WOS:000372432300002
PM 27035299
ER
PT J
AU Sviatenko, LK
Gorb, L
Hill, FC
Leszczynska, D
Leszczynski, J
AF Sviatenko, Liudmyla K.
Gorb, Leonid
Hill, Frances C.
Leszczynska, Danuta
Leszczynski, Jerzy
TI Structure and Electrochemical Properties for Complexes of Nitrocompounds
with Inorganic Ions: A Theoretical Approach
SO JOURNAL OF COMPUTATIONAL CHEMISTRY
LA English
DT Article
DE redox potential; DFT method; nitrocompounds; solvation energy; AIM
theory
ID 2,4,6-TRINITROTOLUENE TNT; ELECTRON-DENSITIES; ACTIVATED CARBON;
HYDROGEN-BONDS; CHARGE-DENSITY; FREE-ENERGIES; OXIDATION; DEGRADATION;
REDUCTION; WATER
AB Reduction and oxidation (redox) reactions are widely used for removal of nitrocompounds from contaminated soil and water. Structures and redox properties for complexes of nitrocompounds, such as 2,4,6-trinitrotoluene (TNT), 2,4-dinitrotoluene (DNT), 2,4-dinitroanisole (DNAN), and 5-nitro-2,4-dihydro-3H-1,2,4-triazol-3-one (NTO), with common inorganic ions (Na+, Cl-, NO3-) were investigated at the SMD(Pauling)/PCM(Pauling)/MPWB1K/TZVP level of theory. Atoms in molecules (AIM) theory was applied to analyze the topological properties of the bond critical points involved in the interactions between the nitrocompounds and the ions. Topological analyses show that intermolecular interactions of the types O(N)center dot center dot center dot Na+, C-H center dot center dot center dot Cl- (ONO2-), and C center dot center dot center dot Cl- (ONO2-) may be discussed as noncovalent closed-shell interactions, while NH center dot center dot center dot Cl- (ONO2-) hydrogen bonds are partially covalent in nature. Complexation causes significant decrease of redox activity of the nitrocompounds. Analysis of the reduction potentials of the complexes obtained through application of the Pourbaix diagram of an iron/water system revealed that sodium complexes of NTO might be reduced by metallic iron. (C) 2016 Wiley Periodicals, Inc.
C1 [Sviatenko, Liudmyla K.] Jackson State Univ, Dept Chem & Biochem, Interdisciplinary Nanotox Ctr, Jackson, MS 39217 USA.
[Sviatenko, Liudmyla K.] Oles Honchar Dnipropetrovsk Natl Univ, Dept Organ Chem, UA-49010 Dnepropetrovsk, Ukraine.
[Gorb, Leonid] HX5 LLC, Vicksburg, MS 39180 USA.
[Hill, Frances C.] US Army, Erdc, Vicksburg, MS 39180 USA.
[Leszczynska, Danuta] Jackson State Univ, Interdisciplinary Nanotox Ctr, Dept Civil & Environm Engn, Jackson, MS 39217 USA.
[Leszczynski, Jerzy] Jackson State Univ, Interdisciplinary Nanotox Ctr, Dept Chem & Biochem, Jackson, MS 39217 USA.
RP Leszczynski, J (reprint author), Jackson State Univ, Interdisciplinary Nanotox Ctr, Dept Chem & Biochem, Jackson, MS 39217 USA.
EM jerzy@icnanotox.org
FU ERDC [W912HZ-13-P-0037]; National Science Foundation [OCI-1053575];
XSEDE [DMR110088]; Mississippi Center for Supercomputer Research
FX Contract grant sponsor: ERDC; Contract grant number: W912HZ-13-P-0037;
Contract grant sponsor: National Science Foundation; Contract grant
number: OCI-1053575; Contract grant sponsor: XSEDE; Contract grant
number: DMR110088; Contract grant sponsor: Mississippi Center for
Supercomputer Research
NR 37
TC 0
Z9 0
U1 3
U2 6
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0192-8651
EI 1096-987X
J9 J COMPUT CHEM
JI J. Comput. Chem.
PD MAR 15
PY 2016
VL 37
IS 13
BP 1206
EP 1213
DI 10.1002/jcc.24310
PG 8
WC Chemistry, Multidisciplinary
SC Chemistry
GA DK1WY
UT WOS:000374707000006
PM 26813584
ER
PT J
AU Kohrt, HE
Tumeh, PC
Benson, D
Bhardwaj, N
Brody, J
Formenti, S
Fox, BA
Galon, J
June, CH
Kalos, M
Kirsch, I
Kleen, T
Kroemer, G
Lanier, L
Levy, R
Lyerly, HK
Maecker, H
Marabelle, A
Melenhorst, J
Miller, J
Melero, I
Odunsi, K
Palucka, K
Peoples, G
Ribas, A
Robins, H
Robinson, W
Serafini, T
Sondel, P
Vivier, E
Weber, J
Wolchok, J
Zitvogel, L
Disis, ML
Cheever, MA
AF Kohrt, Holbrook E.
Tumeh, Paul C.
Benson, Don
Bhardwaj, Nina
Brody, Joshua
Formenti, Silvia
Fox, Bernard A.
Galon, Jerome
June, Carl H.
Kalos, Michael
Kirsch, Ilan
Kleen, Thomas
Kroemer, Guido
Lanier, Lewis
Levy, Ron
Lyerly, H. Kim
Maecker, Holden
Marabelle, Aurelien
Melenhorst, Jos
Miller, Jeffrey
Melero, Ignacio
Odunsi, Kunle
Palucka, Karolina
Peoples, George
Ribas, Antoni
Robins, Harlan
Robinson, William
Serafini, Tito
Sondel, Paul
Vivier, Eric
Weber, Jeff
Wolchok, Jedd
Zitvogel, Laurence
Disis, Mary L.
Cheever, Martin A.
CA CITN
TI Immunodynamics: a cancer immunotherapy trials network review of immune
monitoring in immuno-oncology clinical trials
SO JOURNAL FOR IMMUNOTHERAPY OF CANCER
LA English
DT Review
DE Immunotherapy; Biomarker; Clinical trial
ID NATURAL-KILLER-CELLS; C-RECEPTOR POLYMORPHISMS; IN-SITU VACCINATION;
T-CELLS; ANTI-PD-L1 ANTIBODY; BREAST-CANCER; RECOGNITION EFFICIENCY;
NIVOLUMAB ANTI-PD-1; METASTATIC MELANOMA; FOLLICULAR LYMPHOMA
AB The efficacy of PD-1/PD-L1 targeted therapies in addition to anti-CTLA-4 solidifies immunotherapy as a modality to add to the anticancer arsenal. Despite raising the bar of clinical efficacy, immunologically targeted agents raise new challenges to conventional drug development paradigms by highlighting the limited relevance of assessing standard pharmacokinetics (PK) and pharmacodynamics (PD). Specifically, systemic and intratumoral immune effects have not consistently correlated with standard relationships between systemic dose, toxicity, and efficacy for cytotoxic therapies. Hence, PK and PD paradigms remain inadequate to guide the selection of doses and schedules, both starting and recommended Phase 2 for immunotherapies. The promise of harnessing the immune response against cancer must also be considered in light of unique and potentially serious toxicities. Refining immune endpoints to better inform clinical trial design represents a high priority challenge. The Cancer Immunotherapy Trials Network investigators review the immunodynamic effects of specific classes of immunotherapeutic agents to focus immune assessment modalities and sites, both systemic and importantly intratumoral, which are critical to the success of the rapidly growing field of immuno-oncology.
C1 [Kohrt, Holbrook E.] Stanford Univ, Med Ctr, Stanford Canc Inst, Div Oncol, 269 Campus Dr,CCSR 1105, Stanford, CA 94305 USA.
[Tumeh, Paul C.] Univ Calif Los Angeles, Dept Med, Div Dermatol, Los Angeles, CA 90024 USA.
[Benson, Don] Ohio State Univ, Div Hematol Oncol, Columbus, OH 43210 USA.
[Bhardwaj, Nina] Mt Sinai Hosp, Med Hematol & Med Oncol, New York, NY 10029 USA.
[Brody, Joshua] Mt Sinai Hosp, Ruttenberg Treatment Ctr, Med Hematol & Med Oncol, New York, NY 10029 USA.
[Formenti, Silvia] New York Weill Cornell Med Ctr, Dept Radiat Oncol, New York, NY USA.
[Fox, Bernard A.] OHSU Canc Inst, Lab Mol & Tumor Immunol, SOM Mol Microbiol & Immunol Dept, Portland, OR USA.
[Galon, Jerome] INSERM, Integrat Canc Immunol Team, Cordeliers Res Ctr, Paris, France.
[June, Carl H.] Univ Penn, Perelman Sch Med, Pathol & Lab Med, Philadelphia, PA 19104 USA.
[Kalos, Michael] Eli Lilly & Co, Canc Immunobiol, New York, NY USA.
[Kirsch, Ilan] Adapt Biotechnol Corp, Translat Med, Seattle, WA USA.
[Kleen, Thomas] Epiontis GmbH, Immune Monitoring, Berlin, Germany.
[Kroemer, Guido] Univ Paris 05, Fac Med, Paris, France.
[Lanier, Lewis] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA.
[Levy, Ron] Stanford Sch Med, Div Oncol, Stanford, CA USA.
[Lyerly, H. Kim] Duke Univ, Sch Med, Durham, NC USA.
[Maecker, Holden] Stanford Canc Inst, Human Immune Monitoring Ctr Shared Resource, Stanford, CA USA.
[Marabelle, Aurelien] Leon Berard Canc Ctr, Lyon, France.
[Melenhorst, Jos] Smilow Ctr Translat Res, Prod Dev & Correlat Sci, Philadelphia, PA USA.
[Miller, Jeffrey] Univ Minnesota, Div Hematol Expt Therapeut, Oncol & Transplantat, Minneapolis, MN USA.
[Melero, Ignacio] Univ Navarra, Ctr Invest Med Aplicada, E-31080 Pamplona, Spain.
[Odunsi, Kunle] Roswell Pk Canc Inst, Ctr Immunotherapy, Buffalo, NY 14263 USA.
[Palucka, Karolina] Baylor Inst Immunol Res, Dallas, TX USA.
[Peoples, George] Brooke Army Med Ctr, Canc Vaccine Dev Program, Houston, TX USA.
[Ribas, Antoni] Univ Calif Los Angeles, Tumor Immunol Program Area Jonsson Comprehens Ctr, Los Angeles, CA USA.
[Robins, Harlan] Adapt Biotechnol, Seattle, WA USA.
[Robinson, William] Stanford Univ, Sch Med, Dept Med, Div Immunol & Rheumatol, Stanford, CA 94305 USA.
[Serafini, Tito] Atreca Inc, Redwood City, CA USA.
[Sondel, Paul] Univ Wisconsin, Cellular & Mol Pathol Grad Program, Madison, WI USA.
[Vivier, Eric] Ctr Immunol Marseille Luminy, Marseille, France.
[Weber, Jeff] Univ S Florida, H Lee Moffitt Canc Ctr, Tampa, FL 33682 USA.
[Wolchok, Jedd] Mem Sloan Kettering Canc Ctr, Immunol Program, 1275 York Ave, New York, NY 10021 USA.
[Zitvogel, Laurence] Inst GrustaveRoussy, Inst Natl Sante & Rech Med, Villejuif, France.
[Disis, Mary L.] Univ Washington, Tumor Vaccine Grp, Seattle, WA 98195 USA.
[Cheever, Martin A.] Fred Hutchinson Canc Res Ctr, 1100 Eastlake Ave N,E3-300,POB 19024, Seattle, WA 98109 USA.
RP Cheever, MA (reprint author), Fred Hutchinson Canc Res Ctr, 1100 Eastlake Ave N,E3-300,POB 19024, Seattle, WA 98109 USA.
EM mcheever@fredhutch.org
OI MELERO BERMEJO, IGNACIO/0000-0002-1360-348X
FU NCI NIH HHS [P30 CA124435, R35 CA197078, P30 CA008748, P50 CA159981]
NR 124
TC 7
Z9 8
U1 9
U2 19
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 2051-1426
J9 J IMMUNOTHER CANCER
JI J. Immunother. Cancer
PD MAR 15
PY 2016
VL 4
AR 15
DI 10.1186/s40425-016-0118-0
PG 16
WC Oncology
SC Oncology
GA DH1LI
UT WOS:000372545100004
PM 26981245
ER
PT J
AU Leon, LR
AF Leon, Lisa R.
TI Common mechanisms for the adaptive responses to exercise and heat stress
SO JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Editorial Material
ID ENDOTOXEMIA
C1 [Leon, Lisa R.] US Army, Environm Med Res Inst, Thermal & Mt Med Div, Kansas St,Bldg 42, Natick, MA 01760 USA.
RP Leon, LR (reprint author), US Army, Environm Med Res Inst, Thermal & Mt Med Div, Kansas St,Bldg 42, Natick, MA 01760 USA.
EM lisa.r.leon.civ@mail.mil
NR 13
TC 0
Z9 0
U1 2
U2 4
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 8750-7587
EI 1522-1601
J9 J APPL PHYSIOL
JI J. Appl. Physiol.
PD MAR 15
PY 2016
VL 120
IS 6
BP 662
EP 663
DI 10.1152/japplphysiol.00113.2016
PG 2
WC Physiology; Sport Sciences
SC Physiology; Sport Sciences
GA DG4RU
UT WOS:000372061000016
PM 26869706
ER
PT J
AU Tecson, KM
Silver, MA
Brune, SD
Cauthen, C
Kwan, MD
Schussler, JM
Vasudevan, A
Watts, JA
McCullough, PA
AF Tecson, Kristen M.
Silver, Marc A.
Brune, Sonja D.
Cauthen, Clay
Kwan, Michael D.
Schussler, Jeffrey M.
Vasudevan, Anupama
Watts, James A.
McCullough, Peter A.
TI Impact of Enhanced External Counterpulsation on Heart Failure
Rehospitalization in Patients With Ischemic Cardiomyopathy
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Article
ID ASSOCIATION; DISEASE; UPDATE
AB Heart failure (HF) affects millions of Americans and causes financial burdens because of the need for rehospitalization. For this reason, health care systems and patients alike are seeking methods to decrease readmissions. We assessed the potential for reducing readmissions of patients with postacute care HF through an educational program combined with enhanced external counterpulsation (EECP). We examined 99 patients with HF who were referred to EECP centers and received heart failure education and EECP treatment within 90 days of hospital discharge from March 2013 to January 2015. We compared observed and predicted 90-day readmission rates and examined results of 6-minute walk tests, Duke Activity Status Index, New York Heart Association classification, and Canadian Cardiovascular Society classification before and after EECP. Patients were treated with EECP at a median augmentation pressure of 280 mm Hg (quartile 1 = 240, quartile 3 = 280), achieved as early as the first treatment. Augmentation ratios varied from 0.4 to 1.9, with a median of 1.0 (quartile 1 = 0.8, quartile 3 = 1.2). Only 6 patients (6.1%) had unplanned readmissions compared to the predicted 34%, p <0.0001. The average increase in distance walked was 52 m (18.4%), and the median increase in Duke Activity Status Index was 9.95 points (100%), p values <0.0001. New York Heart Association and Canadian Cardiovascular Society classes improved in 61% and 60% of the patients, respectively. In conclusion, patients with HF who received education and EECP within 90 days of discharge had significantly lower readmission rates than predicted, and improved functional status, walk distance, and symptoms. (c) 2016 Elsevier Inc. All rights reserved.
C1 [Tecson, Kristen M.; Vasudevan, Anupama; McCullough, Peter A.] Baylor Univ, Med Ctr, Baylor Heart & Vasc Inst, Dallas, TX USA.
[Silver, Marc A.] Advocate Christ Med Ctr, Dept Med, Oak Lawn, IL USA.
[Brune, Sonja D.] UT Med, UT Med Cardiol, San Antonio, TX USA.
[Cauthen, Clay] Seton Heart Inst, Dell Med Sch, Austin, TX USA.
[Kwan, Michael D.] MHS Hlth, Adv Heart Failure & Cardiac Transplant Program, San Antonio, TX USA.
[Schussler, Jeffrey M.; McCullough, Peter A.] Baylor Univ, Med Ctr, Div Cardiol, Dallas, TX USA.
[Watts, James A.] Brooke Army Med Ctr, Div Cardiol, San Antonio, TX USA.
[McCullough, Peter A.] Baylor Jack & Jane Hamilton Heart & Vasc Hosp, Div Cardiol, Dallas, TX USA.
[McCullough, Peter A.] Heart Hosp Baylor Plano, Div Cardiol, Plano, TX USA.
RP McCullough, PA (reprint author), Baylor Univ, Med Ctr, Baylor Heart & Vasc Inst, Dallas, TX USA.; McCullough, PA (reprint author), Baylor Univ, Med Ctr, Div Cardiol, Dallas, TX USA.; McCullough, PA (reprint author), Baylor Jack & Jane Hamilton Heart & Vasc Hosp, Div Cardiol, Dallas, TX USA.; McCullough, PA (reprint author), Heart Hosp Baylor Plano, Div Cardiol, Plano, TX USA.
EM peteramccullough@gmail.com
OI Watts, James/0000-0003-1118-838X
FU Baylor Foundation; Legacy (Trinity) Heart Care
FX This work was funded by the Baylor Foundation and Legacy (Trinity) Heart
Care.
NR 17
TC 0
Z9 0
U1 3
U2 3
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9149
EI 1879-1913
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD MAR 15
PY 2016
VL 117
IS 6
BP 901
EP 905
DI 10.1016/j.amjcard.2015.12.024
PG 5
WC Cardiac & Cardiovascular Systems
SC Cardiovascular System & Cardiology
GA DG5RH
UT WOS:000372135800004
PM 26813739
ER
PT J
AU Rasmussen, TE
Crowder, AT
AF Rasmussen, Todd E.
Crowder, Alicia T.
TI Synergy in Science and Resources
SO JOURNAL OF NEUROTRAUMA
LA English
DT Editorial Material
C1 [Rasmussen, Todd E.; Crowder, Alicia T.] US Army, Med Res & Mat Command, United States Combat Casualty Care Res Program, Ft Detrick, MD USA.
[Rasmussen, Todd E.] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, Bethesda, MD 20814 USA.
RP Rasmussen, TE (reprint author), United States Combat Casualty Care Res Program, 504 Scott St, Ft Detrick, MD 21702 USA.
EM todd.e.rasmussen.mil@mail.mil
NR 2
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD MAR 15
PY 2016
VL 33
IS 6
BP 511
EP 512
DI 10.1089/neu.2016.29007.ter
PG 2
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA DG6HN
UT WOS:000372184800001
PM 26982882
ER
PT J
AU Kochanek, PM
Bramlett, HM
Dixon, CE
Shear, DA
Dietrich, WD
Schmid, KE
Mondello, S
Wang, KKW
Hayes, RL
Povlishock, JT
Tortella, FC
AF Kochanek, Patrick M.
Bramlett, Helen M.
Dixon, C. Edward
Shear, Deborah A.
Dietrich, W. Dalton
Schmid, Kara E.
Mondello, Stefania
Wang, Kevin K. W.
Hayes, Ronald L.
Povlishock, John T.
Tortella, Frank C.
TI Approach to Modeling, Therapy Evaluation, Drug Selection, and Biomarker
Assessments for a Multicenter Pre-Clinical Drug Screening Consortium for
Acute Therapies in Severe Traumatic Brain Injury: Operation Brain Trauma
Therapy
SO JOURNAL OF NEUROTRAUMA
LA English
DT Article
DE therapy; rat; penetrating ballistic-like brain injury; biomarker;
micropig; controlled cortical impact; fluid percussion; neuroprotection
ID CONTROLLED CORTICAL IMPACT; TIME-DEPENDENT CHANGES; SEVERE HEAD-INJURY;
HEMORRHAGIC-SHOCK; RAT MODEL; CEREBROSPINAL-FLUID; CONTROLLED-TRIAL;
MICE; DAMAGE; AMANTADINE
AB Traumatic brain injury (TBI) was the signature injury in both the Iraq and Afghan wars and the magnitude of its importance in the civilian setting is finally being recognized. Given the scope of the problem, new therapies are needed across the continuum of care. Few therapies have been shown to be successful. In severe TBI, current guidelines-based acute therapies are focused on the reduction of intracranial hypertension and optimization of cerebral perfusion. One factor considered important to the failure of drug development and translation in TBI relates to the recognition that TBI is extremely heterogeneous and presents with multiple phenotypes even within the category of severe injury. To address this possibility and attempt to bring the most promising therapies to clinical trials, we developed Operation Brain Trauma Therapy (OBTT), a multicenter, pre-clinical drug screening consortium for acute therapies in severe TBI. OBTT was developed to include a spectrum of established TBI models at experienced centers and assess the effect of promising therapies on both conventional outcomes and serum biomarker levels. In this review, we outline the approach to TBI modeling, evaluation of therapies, drug selection, and biomarker assessments for OBTT, and provide a framework for reports in this issue on the first five therapies evaluated by the consortium.
C1 [Kochanek, Patrick M.] Univ Pittsburgh, Sch Med, Safar Ctr Resuscitat Res, Dept Crit Care Med, 3434 Fifth Ave, Pittsburgh, PA 15260 USA.
[Bramlett, Helen M.] Univ Miami, Miller Sch Med, Dept Neurol Surg, Miami Project Cure Paralysis, Miami, FL 33136 USA.
[Bramlett, Helen M.] Vet Affairs Med Ctr, Bruce W Carter Dept, Miami, FL 33125 USA.
[Dixon, C. Edward] Univ Pittsburgh, Sch Med, Brain Trauma Res Ctr, Dept Neurol Surg, Pittsburgh, PA 15260 USA.
[Shear, Deborah A.] Walter Reed Army Inst Res, Ctr Excellence Psychiat & Neurosci, Brain Trauma Neuroprotect & Neurorestorat Branch, In Vivo Neuroprotect Labs, Silver Spring, MD USA.
[Dietrich, W. Dalton] Univ Miami, Miller Sch Med, Dept Neurol Surg, Miami Project Cure Paralysis, Miami, FL 33136 USA.
[Dietrich, W. Dalton] Univ Miami, Miller Sch Med, Dept Neurol, Miami, FL 33136 USA.
[Dietrich, W. Dalton] Univ Miami, Miller Sch Med, Dept Cell Biol, Miami, FL 33136 USA.
[Schmid, Kara E.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect & Neurorestorat Dept, Silver Spring, MD USA.
[Mondello, Stefania] Univ Messina, Dept Neurosci, Messina, Italy.
[Wang, Kevin K. W.] Univ Florida, Dept Psychiat & Neurosci, Ctr Neuroprote & Biomarkers Res, Gainesville, FL USA.
[Hayes, Ronald L.] Banyan Biomarkers Inc, Ctr Neuroprote & Biomarkers, Ctr Innovat Res, Alachua, FL USA.
[Povlishock, John T.] Virginia Commonwealth Univ, Dept Anat & Neurobiol, Richmond, VA USA.
[Tortella, Frank C.] Walter Reed Army Inst Res, Dept Appl Neurobiol, Silver Spring, MD USA.
[Tortella, Frank C.] Walter Reed Army Inst Res, Combat Casualty Care Res Program Brain Trauma & N, Silver Spring, MD USA.
RP Kochanek, PM (reprint author), Univ Pittsburgh, Sch Med, Safar Ctr Resuscitat Res, Dept Crit Care Med, 3434 Fifth Ave, Pittsburgh, PA 15260 USA.
EM kochanekpm@ccm.upmc.edu
NR 67
TC 10
Z9 10
U1 6
U2 11
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD MAR 15
PY 2016
VL 33
IS 6
BP 513
EP 522
DI 10.1089/neu.2015.4113
PG 10
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA DG6HN
UT WOS:000372184800002
PM 26439468
ER
PT J
AU Shear, DA
Dixon, CE
Bramlett, HM
Mondello, S
Dietrich, WD
Deng-Bryant, Y
Schmid, KE
Wang, KKW
Hayes, RL
Povlishock, JT
Kochanek, PM
Tortella, FC
AF Shear, Deborah A.
Dixon, C. Edward
Bramlett, Helen M.
Mondello, Stefania
Dietrich, W. Dalton
Deng-Bryant, Ying
Schmid, Kara E.
Wang, Kevin K. W.
Hayes, Ronald L.
Povlishock, John T.
Kochanek, Patrick M.
Tortella, Frank C.
TI Nicotinamide Treatment in Traumatic Brain Injury: Operation Brain Trauma
Therapy
SO JOURNAL OF NEUROTRAUMA
LA English
DT Article
DE therapy; fluid percussion; rat; biomarker; vitamin B; neuroprotection;
penetrating ballistic-like brain injury; controlled cortical impact
ID FOCAL CEREBRAL-ISCHEMIA; IMPROVES FUNCTIONAL RECOVERY; CORTICAL
CONTUSION INJURY; FLUID PERCUSSION INJURY; INFARCT VOLUME; WISTAR RATS;
HYPOTHERMIA THERAPY; DELAYED TREATMENT; MODEL; PRECURSOR
AB Nicotinamide (vitamin B-3) was the first drug selected for cross-model testing by the Operation Brain Trauma Therapy (OBTT) consortium based on a compelling record of positive results in pre-clinical models of traumatic brain injury (TBI). Adult male Sprague-Dawley rats were exposed to either moderate fluid percussion injury (FPI), controlled cortical impact injury (CCI), or penetrating ballistic-like brain injury (PBBI). Nicotinamide (50 or 500 mg/kg) was delivered intravenously at 15 min and 24 h after injury with subsequent behavioral, biomarker, and histopathological outcome assessments. There was an intermediate effect on balance beam performance with the high (500 mg/kg) dose in the CCI model, but no significant therapeutic benefit was detected on any other motor task across the OBTT TBI models. There was an intermediate benefit on working memory with the high dose in the FPI model. A negative effect of the low (50 mg/kg) dose, however, was observed on cognitive outcome in the CCI model, and no cognitive improvement was observed in the PBBI model. Lesion volume analysis showed no treatment effects after either FPI or PBBI, but the high dose of nicotinamide resulted in significant tissue sparing in the CCI model. Biomarker assessments included measurements of glial fibrillary acidic protein (GFAP) and ubiquitin carboxyl-terminal hydrolase-1 (UCH-L1) in blood at 4 or 24 h after injury. Negative effects (both doses) were detected on biomarker levels of GFAP after FPI and on biomarker levels of UCH-L1 after PBBI. The high dose of nicotinamide, however, reduced GFAP levels after both PBBI and CCI. Overall, our results showed a surprising lack of benefit from the low dose nicotinamide. In contrast, and partly in keeping with the literature, some benefit was achieved with the high dose. The marginal benefits achieved with nicotinamide, however, which appeared sporadically across the TBI models, has reduced enthusiasm for further investigation by the OBTT Consortium.
C1 [Shear, Deborah A.; Deng-Bryant, Ying; Schmid, Kara E.; Tortella, Frank C.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect Neurorestorat, Silver Spring, MD USA.
[Dixon, C. Edward] Univ Pittsburgh, Sch Med, Brain Trauma Res Ctr, Dept Neurol Surg, Pittsburgh, PA 15260 USA.
[Bramlett, Helen M.; Dietrich, W. Dalton] Univ Miami, Miller Sch Med, Miami Project Cure Paralysis, Dept Neurol Surg, Miami, FL 33136 USA.
[Bramlett, Helen M.] Vet Affairs Med Ctr, Bruce W Carter Dept, Miami, FL 33125 USA.
[Mondello, Stefania] Univ Messina, Dept Neurosci, Messina, Italy.
[Wang, Kevin K. W.] Univ Florida, Dept Psychiat & Neurosci, Ctr Neuroprote & Biomarkers Res, Gainesville, FL USA.
[Hayes, Ronald L.] Banyan Biomarkers Inc, Ctr Neuroprote & Biomarkers Res, Ctr Innovat Res, Alachua, FL USA.
[Povlishock, John T.] Virginia Commonwealth Univ, Dept Anat & Neurobiol, Richmond, VA USA.
[Kochanek, Patrick M.] Univ Pittsburgh, Sch Med, Safar Ctr Resuscitat Res, Dept Crit Care Med, 3434 Fifth Ave, Pittsburgh, PA 15260 USA.
RP Kochanek, PM (reprint author), Univ Pittsburgh, Sch Med, Safar Ctr Resuscitat Res, Dept Crit Care Med, 3434 Fifth Ave, Pittsburgh, PA 15260 USA.
EM kochanekpm@ccm.upmc.edu
NR 42
TC 7
Z9 8
U1 2
U2 6
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD MAR 15
PY 2016
VL 33
IS 6
BP 523
EP 537
DI 10.1089/neu.2015.4115
PG 15
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA DG6HN
UT WOS:000372184800003
PM 26670792
ER
PT J
AU Bramlett, HM
Dietrich, WD
Dixon, CE
Shear, DA
Schmid, KE
Mondello, S
Wang, KKW
Hayes, RL
Povlishock, JT
Tortella, FC
Kochanek, PM
AF Bramlett, Helen M.
Dietrich, W. Dalton
Dixon, C. Edward
Shear, Deborah A.
Schmid, Kara E.
Mondello, Stefania
Wang, Kevin K. W.
Hayes, Ronald L.
Povlishock, John T.
Tortella, Frank C.
Kochanek, Patrick M.
TI Erythropoietin Treatment in Traumatic Brain Injury: Operation Brain
Trauma Therapy
SO JOURNAL OF NEUROTRAUMA
LA English
DT Article
DE penetrating ballistic-like brain injury; fluid percussion; biomarker;
neuroprotection; rat; controlled cortical impact; therapy
ID RECOMBINANT-HUMAN-ERYTHROPOIETIN; NRF2 SIGNALING PATHWAY; CORTICAL
IMPACT INJURY; FUNCTIONAL RECOVERY; MIMETIC PEPTIDE; RAT-BRAIN; MODEL;
MICE; GENE; TISSUE
AB Experimental studies targeting traumatic brain injury (TBI) have reported that erythropoietin (EPO) is an endogenous neuroprotectant in multiple models. In addition to its neuroprotective effects, it has also been shown to enhance reparative processes including angiogenesis and neurogenesis. Based on compelling pre-clinical data, EPO was tested by the Operation Brain Trauma Therapy (OBTT) consortium to evaluate therapeutic potential in multiple TBI models along with biomarker assessments. Based on the pre-clinical TBI literature, two doses of EPO (5000 and 10,000 IU/kg) were tested given at 15 min after moderate fluid percussion brain injury (FPI), controlled cortical impact (CCI), or penetrating ballistic-like brain injury (PBBI) with subsequent behavioral, histopathological, and biomarker outcome assessments. There was a significant benefit on beam walk with the 5000 IU dose in CCI, but no benefit on any other motor task across models in OBTT. Also, no benefit of EPO treatment across the three TBI models was noted using the Morris water maze to assess cognitive deficits. Lesion volume analysis showed no treatment effects after either FPI or CCI; however, with the 5000 IU/kg dose of EPO, a paradoxical increase in lesion volume and percent hemispheric tissue loss was seen after PBBI. Biomarker assessments included measurements of glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase-L1 (UCH-L1) in blood at 4 or 24 h after injury. No treatment effects were seen on biomarker levels after FPI, whereas treatment at either dose exacerbated the increase in GFAP at 24 h in PBBI but attenuated 24-4 h delta UCH-L1 levels at high dose in CCI. Our data indicate a surprising lack of efficacy of EPO across three established TBI models in terms of behavioral, histopathological, and biomarker assessments. Although we cannot rule out the possibility that other doses or more prolonged treatment could show different effects, the lack of efficacy of EPO reduced enthusiasm for its further investigation in OBTT.
C1 [Bramlett, Helen M.; Dietrich, W. Dalton] Univ Miami, Miller Sch Med, Dept Neurol Surg, Miami Project Cure Paralysis, Miami, FL 33136 USA.
[Bramlett, Helen M.] Vet Affairs Med Ctr, Bruce W Carter Dept, Miami, FL 33125 USA.
[Dixon, C. Edward] Univ Pittsburgh, Sch Med, Brain Trauma Res Ctr, Dept Neurol Surg, Pittsburgh, PA 15260 USA.
[Shear, Deborah A.; Schmid, Kara E.; Tortella, Frank C.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect Neurorestorat, Silver Spring, MD USA.
[Mondello, Stefania] Univ Messina, Dept Neurosci, Messina, Italy.
[Wang, Kevin K. W.] Univ Florida, Dept Psychiat & Neurosci, Ctr Neuroprote & Biomarkers Res, Gainesville, FL USA.
[Hayes, Ronald L.] Banyan Biomarkers Inc, Ctr Neuroprote & Biomarkers Res, Ctr Innovat Res, Alachua, FL USA.
[Povlishock, John T.] Virginia Commonwealth Univ, Dept Anat & Neurobiol, Richmond, VA USA.
[Kochanek, Patrick M.] Univ Pittsburgh, Sch Med, Safar Ctr Resuscitat Res, Dept Crit Care Med, 3434 Fifth Ave, Pittsburgh, PA 15260 USA.
RP Kochanek, PM (reprint author), Univ Pittsburgh, Sch Med, Safar Ctr Resuscitat Res, Dept Crit Care Med, 3434 Fifth Ave, Pittsburgh, PA 15260 USA.
EM kochanekpm@ccm.upmc.edu
NR 48
TC 5
Z9 5
U1 2
U2 3
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD MAR 15
PY 2016
VL 33
IS 6
BP 538
EP 552
DI 10.1089/neu.2015.4116
PG 15
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA DG6HN
UT WOS:000372184800004
PM 26670694
ER
PT J
AU Dixon, CE
Bramlett, HM
Dietrich, WD
Shear, DA
Yan, HQ
Deng-Bryant, Y
Mondello, S
Wang, KKW
Hayes, RL
Empey, PE
Povlishock, JT
Tortella, FC
Kochanek, PM
AF Dixon, C. Edward
Bramlett, Helen M.
Dietrich, W. Dalton
Shear, Deborah A.
Yan, Hong Q.
Deng-Bryant, Ying
Mondello, Stefania
Wang, Kevin K. W.
Hayes, Ronald L.
Empey, Philip E.
Povlishock, John T.
Tortella, Frank C.
Kochanek, Patrick M.
TI Cyclosporine Treatment in Traumatic Brain Injury: Operation Brain Trauma
Therapy
SO JOURNAL OF NEUROTRAUMA
LA English
DT Article
DE therapy; rat; biomarker; fluid percussion; calcineurin; neuroprotection;
controlled cortical impact; penetrating ballistic-like brain injury;
phosphatase
ID MITOCHONDRIAL PERMEABILITY TRANSITION; HYPOTHERMIA THERAPY;
DOSE-RESPONSE; AXONAL INJURY; RATS; DAMAGE; MODEL; NIM811; MOTOR
AB Operation Brain Trauma Therapy (OBTT) is a consortium of investigators using multiple pre-clinical models of traumatic brain injury (TBI) to bring acute therapies to clinical trials. To screen therapies, we used three rat models (parasagittal fluid percussion injury [FPI], controlled cortical impact [CCI], and penetrating ballistic-like brain injury [PBBI]). We report results of the third therapy (cyclosporin-A; cyclosporine; [CsA]) tested by OBTT. At each site, rats were randomized to treatment with an identical regimen (TBI + vehicle, TBI + CsA [10 mg/kg], or TBI + CsA [20 mg/kg] given intravenously at 15 min and 24 h after injury, and sham). We assessed motor and Morris water maze (MWM) tasks over 3 weeks after TBI and lesion volume and hemispheric tissue loss at 21 days. In FPI, CsA (10 mg/kg) produced histological protection, but 20 mg/kg worsened working memory. In CCI, CsA (20 mg/kg) impaired MWM performance; surprisingly, neither dose showed benefit on any outcome. After PBBI, neither dose produced benefit on any outcome, and mortality was increased (20 mg/kg) partly caused by the solvent vehicle. In OBTT, CsA produced complex effects with histological protection at the lowest dose in the least severe model (FPI), but only deleterious effects as model severity increased (CCI and PBBI). Biomarker assessments included measurements of glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase-L1 (UCH-L1) in blood at 4 or 24 h after injury. No positive treatment effects were seen on biomarker levels in any of the models, whereas significant increases in 24 h UCH-L1 levels were seen with CsA (20 mg/kg) after CCI and 24 h GFAP levels in both CsA treated groups in the PBBI model. Lack of behavioral protection in any model, indicators of toxicity, and a narrow therapeutic index reduce enthusiasm for clinical translation.
C1 [Dixon, C. Edward; Yan, Hong Q.] Univ Pittsburgh, Sch Med, Brain Trauma Res Ctr, Dept Neurol Surg, Pittsburgh, PA 15260 USA.
[Bramlett, Helen M.; Dietrich, W. Dalton] Univ Miami, Miller Sch Med, Miami Project Cure Paralysis, Dept Neurol Surg, Miami, FL 33136 USA.
[Bramlett, Helen M.] Vet Affairs Med Ctr, Bruce W Carter Dept, Miami, FL 33125 USA.
[Shear, Deborah A.; Deng-Bryant, Ying; Tortella, Frank C.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect Neurorestorat, Silver Spring, MD USA.
[Mondello, Stefania] Univ Messina, Dept Neurosci, Messina, Italy.
[Wang, Kevin K. W.] Univ Florida, Dept Psychiat & Neurosci, Ctr Neuroprote & Biomarkers Res, Gainesville, FL USA.
[Hayes, Ronald L.] Banyan Biomarkers Inc, Ctr Neuroprote & Biomarkers Res, Ctr Innovat Res, Alachua, FL USA.
[Empey, Philip E.] Univ Pittsburgh, Sch Pharm, Ctr Pharmaceut Sci, Pittsburgh, PA 15260 USA.
[Povlishock, John T.] Virginia Commonwealth Univ, Dept Anat & Neurobiol, Richmond, VA USA.
[Kochanek, Patrick M.] Univ Pittsburgh, Sch Med, Safar Ctr Resuscitat Res, Dept Crit Care Med, 3434 Fifth Ave, Pittsburgh, PA 15260 USA.
RP Kochanek, PM (reprint author), Univ Pittsburgh, Sch Med, Safar Ctr Resuscitat Res, Dept Crit Care Med, 3434 Fifth Ave, Pittsburgh, PA 15260 USA.
EM kochanekpm@ccm.upmc.edu
NR 38
TC 4
Z9 5
U1 1
U2 7
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD MAR 15
PY 2016
VL 33
IS 6
BP 553
EP 566
DI 10.1089/neu.2015.4122
PG 14
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA DG6HN
UT WOS:000372184800005
PM 26671075
ER
PT J
AU Mountney, A
Bramlett, HM
Dixon, CE
Mondello, S
Dietrich, WD
Wang, KKW
Caudle, K
Empey, PE
Poloyac, SM
Hayes, RL
Povlishock, JT
Tortella, FC
Kochanek, PM
Shear, DA
AF Mountney, Andrea
Bramlett, Helen M.
Dixon, C. Edward
Mondello, Stefania
Dietrich, W. Dalton
Wang, Kevin K. W.
Caudle, Krista
Empey, Philip E.
Poloyac, Samuel M.
Hayes, Ronald L.
Povlishock, John T.
Tortella, Frank C.
Kochanek, Patrick M.
Shear, Deborah A.
TI Simvastatin Treatment in Traumatic Brain Injury: Operation Brain Trauma
Therapy
SO JOURNAL OF NEUROTRAUMA
LA English
DT Article
DE penetrating ballistic-like brain injury; therapy; micropig; biomarker;
controlled cortical impact; neuroprotection; statin; fluid percussion;
rat
ID EXPERIMENTAL INTRACEREBRAL HEMORRHAGE; ANEURYSMAL SUBARACHNOID
HEMORRHAGE; COA REDUCTASE INHIBITOR; COMBINATION THERAPY; COGNITIVE
DEFICITS; NEURONAL SURVIVAL; GENE-EXPRESSION; RAT; STATINS; MODEL
AB Simvastatin, the fourth drug selected for testing by Operation Brain Trauma Therapy (OBTT), is a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor used clinically to reduce serum cholesterol. In addition, simvastatin has demonstrated potent antineuroinflammatory and brain edema reducing effects and has shown promise in promoting functional recovery in pre-clinical models of traumatic brain injury (TBI). The purpose of this study was to assess the potential neuroprotective effects of oral administration of simvastatin on neurobehavioral, biomarker, and histopathological outcome measures compared across three pre-clinical TBI animal models. Adult male Sprague-Dawley rats were exposed to either moderate fluid percussion injury (FPI), controlled cortical impact injury (CCI), or penetrating ballistic-like brain injury (PBBI). Simvastatin (1 or 5 mg/kg) was delivered via oral gavage at 3 h post-injury and continued once daily out to 14 days post-injury. Results indicated an intermediate beneficial effect of simvastatin on motor performance on the gridwalk (FPI), balance beam (CCI), and rotarod tasks (PBBI). No significant therapeutic benefit was detected, however, on cognitive outcome across the OBTT TBI models. In fact, Morris water maze (MWM) performance was actually worsened by treatment in the FPI model and scored full negative points for low dose in the MWM latency and swim distance to locate the hidden platform. A detrimental effect on cortical tissue loss was also seen in the FPI model, and there were no benefits on histology across the other models. Simvastatin also produced negative effects on circulating glial fibrillary acidic protein biomarker outcomes that were evident in the FPI and PBBI models. Overall, the current findings do not support the beneficial effects of simvastatin administration over 2 weeks post-TBI using the oral route of administration and, as such, it will not be further pursued by OBTT.
C1 [Mountney, Andrea; Caudle, Krista; Tortella, Frank C.; Shear, Deborah A.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect Neurorestorat, Silver Spring, MD USA.
[Bramlett, Helen M.; Dietrich, W. Dalton] Univ Miami, Miller Sch Med, Miami Project Cure Paralysis, Dept Neurol Surg, Miami, FL 33136 USA.
[Bramlett, Helen M.; Dietrich, W. Dalton] Vet Affairs Med Ctr, Bruce W Carter Dept, Miami, FL 33125 USA.
[Dixon, C. Edward] Univ Pittsburgh, Sch Med, Brain Trauma Res Ctr, Dept Neurol Surg, Pittsburgh, PA 15260 USA.
[Mondello, Stefania] Univ Messina, Dept Neurosci, Messina, Italy.
[Wang, Kevin K. W.] Univ Florida, Dept Psychiat & Neurosci, Ctr Neuroprote & Biomarkers Res, Gainesville, FL USA.
[Empey, Philip E.; Poloyac, Samuel M.] Univ Pittsburgh, Sch Pharm, Pittsburgh, PA 15260 USA.
[Hayes, Ronald L.] Banyan Biomarkers Inc, Ctr Neuroprote & Biomarkers Res, Ctr Innovat Res, Alachua, FL USA.
[Povlishock, John T.] Virginia Commonwealth Univ, Dept Anat & Neurobiol, Richmond, VA USA.
[Kochanek, Patrick M.] Univ Pittsburgh, Sch Med, Safar Ctr Resuscitat Res, Dept Crit Care Med, 3434 Fifth Ave, Pittsburgh, PA 15260 USA.
RP Kochanek, PM (reprint author), Univ Pittsburgh, Sch Med, Safar Ctr Resuscitat Res, Dept Crit Care Med, 3434 Fifth Ave, Pittsburgh, PA 15260 USA.
EM kochanekpm@ccm.upmc.edu
NR 50
TC 4
Z9 4
U1 1
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD MAR 15
PY 2016
VL 33
IS 6
BP 567
EP 580
DI 10.1089/neu.2015.4130
PG 14
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA DG6HN
UT WOS:000372184800006
PM 26541177
ER
PT J
AU Browning, M
Shear, DA
Bramlett, HM
Dixon, CE
Mondello, S
Schmid, KE
Poloyac, SM
Dietrich, WD
Hayes, RL
Wang, KKW
Povlishock, JT
Tortella, FC
Kochanek, PM
AF Browning, Megan
Shear, Deborah A.
Bramlett, Helen M.
Dixon, C. Edward
Mondello, Stefania
Schmid, Kara E.
Poloyac, Samuel M.
Dietrich, W. Dalton
Hayes, Ronald L.
Wang, Kevin K. W.
Povlishock, John T.
Tortella, Frank C.
Kochanek, Patrick M.
TI Levetiracetam Treatment in Traumatic Brain Injury: Operation Brain
Trauma Therapy
SO JOURNAL OF NEUROTRAUMA
LA English
DT Article
DE rat; post-traumatic seizures; penetrating ballistic-like brain injury;
fluid percussion; excitotoxicity; controlled cortical impact; biomarker;
Keppra; neuroprotection; therapy
ID CONTROLLED CORTICAL IMPACT; SEIZURE PROPHYLAXIS; INTRAVENOUS
LEVETIRACETAM; POSTTRAUMATIC EPILEPSY; STATUS EPILEPTICUS; MODEL; RAT;
HYPOTHERMIA; DEFICITS; PROTEIN
AB Levetiracetam (LEV) is an antiepileptic agent targeting novel pathways. Coupled with a favorable safety profile and increasing empirical clinical use, it was the fifth drug tested by Operation Brain Trauma Therapy (OBTT). We assessed the efficacy of a single 15 min post-injury intravenous (IV) dose (54 or 170 mg/kg) on behavioral, histopathological, and biomarker outcomes after parasagittal fluid percussion brain injury (FPI), controlled cortical impact (CCI), and penetrating ballistic-like brain injury (PBBI) in rats. In FPI, there was no benefit on motor function, but on Morris water maze (MWM), both doses improved latencies and path lengths versus vehicle (p < 0.05). On probe trial, the vehicle group was impaired versus sham, but both LEV treated groups did not differ versus sham, and the 54 mg/kg group was improved versus vehicle (p < 0.05). No histological benefit was seen. In CCI, there was a benefit on beam balance at 170 mg/kg (p < 0.05 vs. vehicle). On MWM, the 54 mg/kg dose was improved and not different from sham. Probe trial did not differ between groups for either dose. There was a reduction in hemispheric tissue loss (p < 0.05 vs. vehicle) with 170 mg/kg. In PBBI, there was no motor, cognitive, or histological benefit from either dose. Regarding biomarkers, in CCI, 24 h glial fibrillary acidic protein (GFAP) blood levels were lower in the 170 mg/kg group versus vehicle (p < 0.05). In PBBI, GFAP blood levels were increased in vehicle and 170 mg/kg groups versus sham (p < 0.05) but not in the 54 mg/kg group. No treatment effects were seen for ubiquitin C-terminal hydrolase-L1 across models. Early single IV LEV produced multiple benefits in CCI and FPI and reduced GFAP levels in PBBI. LEV achieved 10 points at each dose, is the most promising drug tested thus far by OBTT, and the only drug to improve cognitive outcome in any model. LEV has been advanced to testing in the micropig model in OBTT.
C1 [Browning, Megan; Kochanek, Patrick M.] Univ Pittsburgh, Sch Med, Safar Ctr Resuscitat Res, Dept Crit Care Med, 3434 Fifth Ave, Pittsburgh, PA 15260 USA.
[Shear, Deborah A.; Schmid, Kara E.; Tortella, Frank C.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect Neurorestorat, Silver Spring, MD USA.
[Bramlett, Helen M.; Dietrich, W. Dalton] Univ Miami, Miller Sch Med, Dept Neurol Surg, Miami Project Cure Paralysis, Miami, FL 33136 USA.
[Bramlett, Helen M.] Vet Affairs Med Ctr, Bruce W Carter Dept, Miami, FL 33125 USA.
[Dixon, C. Edward] Univ Pittsburgh, Sch Med, Brain Trauma Res Ctr, Dept Neurol Surg, Pittsburgh, PA 15260 USA.
[Mondello, Stefania] Univ Messina, Dept Neurosci, Messina, Italy.
[Poloyac, Samuel M.] Univ Pittsburgh, Sch Pharm, Ctr Pharmaceut Sci, Pittsburgh, PA 15260 USA.
[Hayes, Ronald L.] Banyan Biomarkers Inc, Ctr Neuroprote & Biomarkers Res, Ctr Innovat Res, Alachua, FL USA.
[Wang, Kevin K. W.] Univ Florida, Dept Psychiat & Neurosci, Ctr Neuroprote & Biomarkers Res, Gainesville, FL USA.
[Povlishock, John T.] Virginia Commonwealth Univ, Dept Anat & Neurobiol, Richmond, VA USA.
RP Kochanek, PM (reprint author), Univ Pittsburgh, Sch Med, Safar Ctr Resuscitat Res, Dept Crit Care Med, 3434 Fifth Ave, Pittsburgh, PA 15260 USA.
EM kochanekpm@ccm.upmc.edu
NR 40
TC 9
Z9 9
U1 1
U2 4
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD MAR 15
PY 2016
VL 33
IS 6
BP 581
EP 594
DI 10.1089/neu.2015.4131
PG 14
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA DG6HN
UT WOS:000372184800007
PM 26671550
ER
PT J
AU Mondello, S
Shear, DA
Bramlett, HM
Dixon, CE
Schmid, KE
Dietrich, WD
Wang, KKW
Hayes, RL
Glushakova, O
Catania, M
Richieri, SP
Povlishock, JT
Tortella, FC
Kochanek, PM
AF Mondello, Stefania
Shear, Deborah A.
Bramlett, Helen M.
Dixon, C. Edward
Schmid, Kara E.
Dietrich, W. Dalton
Wang, Kevin K. W.
Hayes, Ronald L.
Glushakova, Olena
Catania, Michael
Richieri, Steven P.
Povlishock, John T.
Tortella, Frank C.
Kochanek, Patrick M.
TI Insight into Pre-Clinical Models of Traumatic Brain Injury Using
Circulating Brain Damage Biomarkers: Operation Brain Trauma Therapy
SO JOURNAL OF NEUROTRAUMA
LA English
DT Article
DE theranostic; fluid percussion injury; rat; ubiquitin carboxyl-terminal
hydrolase-L1; penetrating ballistic-like brain injury; biomarkers; glial
fibrillary acidic protein; Morris water maze; controlled cortical impact
ID BARRIER PERMEABILITY; BLOOD; FLUID; RATS; HYPOTHERMIA; BREAKDOWN;
SEVERITY; MARKERS
AB Operation Brain Trauma Therapy (OBTT) is a multicenter pre-clinical drug screening consortium testing promising therapies for traumatic brain injury (TBI) in three well-established models of TBI in rats-namely, parasagittal fluid percussion injury (FPI), controlled cortical impact (CCI), and penetrating ballistic-like brain injury (PBBI). This article presents unique characterization of these models using histological and behavioral outcomes and novel candidate biomarkers from the first three treatment trials of OBTT. Adult rats underwent CCI, FPI, or PBBI and were treated with vehicle (VEH). Shams underwent all manipulations except trauma. The glial marker glial fibrillary acidic protein (GFAP) and the neuronal marker ubiquitin C-terminal hydrolase (UCH-L1) were measured by enzyme-linked immunosorbent assay in blood at 4 and 24 h, and their delta 24-4 h was calculated for each marker. Comparing sham groups across experiments, no differences were found in the same model. Similarly, comparing TBI + VEH groups across experiments, no differences were found in the same model. GFAP was acutely increased in injured rats in each model, with significant differences in levels and temporal patterns mirrored by significant differences in delta 24-4 h GFAP levels and neuropathological and behavioral outcomes. Circulating GFAP levels at 4 and 24 h were powerful predictors of 21 day contusion volume and tissue loss. UCH-L1 showed similar tendencies, albeit with less robust differences between sham and injury groups. Significant differences were also found comparing shams across the models. Our findings (1) demonstrate that TBI models display specific biomarker profiles, functional deficits, and pathological consequence; (2) support the concept that there are different cellular, molecular, and pathophysiological responses to TBI in each model; and (3) advance our understanding of TBI, providing opportunities for a successful translation and holding promise for theranostic applications. Based on our findings, additional studies in pre-clinical models should pursue assessment of GFAP as a surrogate histological and/or theranostic end-point.
C1 [Mondello, Stefania] Univ Messina, Dept Neurosci, Messina, Italy.
[Shear, Deborah A.; Schmid, Kara E.; Tortella, Frank C.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect Neurorestorat, Silver Spring, MD USA.
[Bramlett, Helen M.; Dietrich, W. Dalton] Univ Miami, Miller Sch Med, Miami Project Cure Paralysis, Dept Neurol Surg, Miami, FL 33136 USA.
[Bramlett, Helen M.] Vet Affairs Med Ctr, Bruce W Carter Dept, Miami, FL 33125 USA.
[Dixon, C. Edward] Univ Pittsburgh, Sch Med, Brain Trauma Res Ctr, Dept Neurol Surg, Pittsburgh, PA 15260 USA.
[Wang, Kevin K. W.] Univ Florida, Dept Psychiat & Neurosci, Ctr Neuroprote & Biomarkers Res, Gainesville, FL USA.
[Hayes, Ronald L.] Banyan Biomarkers Inc, Ctr Neuroprote & Biomarkers Res, Ctr Innovat Res, Alachua, FL USA.
[Glushakova, Olena; Catania, Michael; Richieri, Steven P.] Banyan Biomarkers, Alachua, FL USA.
[Povlishock, John T.] Virginia Commonwealth Univ, Dept Anat & Neurobiol, Richmond, VA USA.
[Kochanek, Patrick M.] Univ Pittsburgh, Sch Med, Dept Crit Care Med, Safar Ctr Resuscitat Res, 3434 Fifth Ave, Pittsburgh, PA 15260 USA.
RP Kochanek, PM (reprint author), Univ Pittsburgh, Sch Med, Dept Crit Care Med, Safar Ctr Resuscitat Res, 3434 Fifth Ave, Pittsburgh, PA 15260 USA.
EM kochanekpm@ccm.upmc.edu
NR 31
TC 9
Z9 9
U1 2
U2 7
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD MAR 15
PY 2016
VL 33
IS 6
BP 595
EP 605
DI 10.1089/neu.2015.4132
PG 11
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA DG6HN
UT WOS:000372184800008
PM 26671651
ER
PT J
AU Kochanek, PM
Bramlett, HM
Shear, DA
Dixon, CE
Mondello, S
Dietrich, WD
Hayes, RL
Wang, KKW
Poloyac, SM
Empey, PE
Povlishock, JT
Mountney, A
Browning, M
Deng-Bryant, Y
Yan, HQ
Jackson, TC
Catania, M
Glushakova, O
Richieri, SP
Tortella, FC
AF Kochanek, Patrick M.
Bramlett, Helen M.
Shear, Deborah A.
Dixon, C. Edward
Mondello, Stefania
Dietrich, W. Dalton
Hayes, Ronald L.
Wang, Kevin K. W.
Poloyac, Samuel M.
Empey, Philip E.
Povlishock, John T.
Mountney, Andrea
Browning, Megan
Deng-Bryant, Ying
Yan, Hong Q.
Jackson, Travis C.
Catania, Michael
Glushakova, Olena
Richieri, Steven P.
Tortella, Frank C.
TI Synthesis of Findings, Current Investigations, and Future Directions:
Operation Brain Trauma Therapy
SO JOURNAL OF NEUROTRAUMA
LA English
DT Article
DE traumatic brain injury; therapy; rat; biomarker; controlled cortical
impact; pre-clinical modeling; micropig; penetrating ballistic-like
brain injury; reproducibility; fluid percussion; drug
ID CONTROLLED CORTICAL IMPACT; MICROGLIAL ACTIVATION; HEMORRHAGIC-SHOCK;
RAT MODEL; INJURY; AMANTADINE; DEFICITS; MICE; NEUROPROTECTION;
PERFORMANCE
AB Operation Brain Trauma Therapy (OBTT) is a fully operational, rigorous, and productive multicenter, pre-clinical drug and circulating biomarker screening consortium for the field of traumatic brain injury (TBI). In this article, we synthesize the findings from the first five therapies tested by OBTT and discuss both the current work that is ongoing and potential future directions. Based on the results generated from the first five therapies tested within the exacting approach used by OBTT, four (nicotinamide, erythropoietin, cyclosporine A, and simvastatin) performed below or well below what was expected based on the published literature. OBTT has identified, however, the early post-TBI administration of levetiracetam as a promising agent and has advanced it to a gyrencephalic large animal model-fluid percussion injury in micropigs. The sixth and seventh therapies have just completed testing (glibenclamide and Kollidon VA 64), and an eighth drug (AER 271) is in testing. Incorporation of circulating brain injury biomarker assessments into these pre-clinical studies suggests considerable potential for diagnostic and theranostic utility of glial fibrillary acidic protein in pre-clinical studies. Given the failures in clinical translation of therapies in TBI, rigorous multicenter, pre-clinical approaches to therapeutic screening such as OBTT may be important for the ultimate translation of therapies to the human condition.
C1 [Kochanek, Patrick M.; Browning, Megan; Jackson, Travis C.] Univ Pittsburgh, Sch Med, Safar Ctr Resuscitat Res, Dept Crit Care Med, 3434 Fifth Ave, Pittsburgh, PA 15260 USA.
[Bramlett, Helen M.; Dietrich, W. Dalton] Univ Miami, Miller Sch Med, Miami Project Cure Paralysis, Dept Neurol Surg, Miami, FL 33136 USA.
[Bramlett, Helen M.] Vet Affairs Med Ctr, Bruce W Carter Dept, Miami, FL 33125 USA.
[Shear, Deborah A.; Mountney, Andrea; Deng-Bryant, Ying; Tortella, Frank C.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect Neurorestorat, Silver Spring, MD USA.
[Dixon, C. Edward; Yan, Hong Q.] Univ Pittsburgh, Sch Med, Brain Trauma Res Ctr, Dept Neurol Surg, Pittsburgh, PA 15260 USA.
[Mondello, Stefania] Univ Messina, Dept Neurosci, Messina, Italy.
[Hayes, Ronald L.] Banyan Biomarkers Inc, Ctr Neuroprote & Biomarkers Res, Ctr Innovat Res, Alachua, FL USA.
[Wang, Kevin K. W.] Univ Florida, Dept Psychiat & Neurosci, Ctr Neuroprote & Biomarkers Res, Gainesville, FL USA.
[Poloyac, Samuel M.; Empey, Philip E.] Univ Pittsburgh, Sch Pharm, Ctr Pharmaceut Sci, Pittsburgh, PA 15260 USA.
[Povlishock, John T.] Virginia Commonwealth Univ, Dept Anat & Neurobiol, Richmond, VA USA.
[Catania, Michael; Glushakova, Olena; Richieri, Steven P.] Banyan Biomarkers, Alachua, FL USA.
RP Kochanek, PM (reprint author), Univ Pittsburgh, Sch Med, Safar Ctr Resuscitat Res, Dept Crit Care Med, 3434 Fifth Ave, Pittsburgh, PA 15260 USA.
EM kochanekpm@ccm.upmc.edu
NR 52
TC 4
Z9 4
U1 2
U2 3
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD MAR 15
PY 2016
VL 33
IS 6
BP 606
EP 614
DI 10.1089/neu.2015.4133
PG 9
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA DG6HN
UT WOS:000372184800009
PM 26671284
ER
PT J
AU Morriss, BF
Ochs, E
Deeb, EJ
Newman, SD
Daly, SF
Gagnon, JJ
AF Morriss, B. F.
Ochs, E.
Deeb, E. J.
Newman, S. D.
Daly, S. F.
Gagnon, J. J.
TI Persistence-based temporal filtering for MODIS snow products
SO REMOTE SENSING OF ENVIRONMENT
LA English
DT Article
DE MODIS; Snow covered area; Cloud-free; Gap-fill
ID COVER; ALBEDO
AB Single-day snow covered area (SCA) products are incomplete and often inadequate representations of ground conditions due to short term variation in cloud cover, snow cover, and sensor geometry. To mitigate these effects, we developed a by-pixel filtering algorithm to produce relatively cloud-free SCA products from 16 days of MODIS imagery. The algorithm uses previous days' data to estimate the current SCA value of each pixel and uses a simple persistence test to reduce the effects of spurious SCA/cloud classifications in the input products. To be positively identified as SCA, a pixel must be snow-covered in the two most recent, cloud-free scenes of the 16-day period. We applied this time-domain-filtering (TDF) methodology to two single-day MODIS fractional snow cover products (MOD10A1 and MODSCAG) over the MODIS period of record (2000-present) and compared the outputs to the unfiltered products, to filtered maps generated using the cloud-gap-filled algorithm (CGF, Hall et al., 2010), and to historical snow assessment reports from the U.S. Army Corps of Engineers, Cold Regions Research and Engineering Laboratory (CRREL). The CRREL reports were manually generated and quality-controlled by an analyst and are treated as ground truth. We find that, when applied to MODSCAG, the TDF algorithm successfully fills in gap pixels and limits the effects of snow/cloud confusion and produces a filtered product that is more consistent and accurate than the MODSCAG CGF product and comparable to the MOD10A1 CGF product. (c) 2016 Elsevier Inc All rights reserved.
C1 [Morriss, B. F.; Ochs, E.; Deeb, E. J.; Newman, S. D.; Daly, S. F.; Gagnon, J. J.] US Army Corps Engineers, Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH USA.
RP Morriss, BF (reprint author), US Army Corps Engineers, Cold Reg Res & Engn Lab USACE CRREL, Hanover, NH USA.
EM blaine.f.morriss@erdc.dren.mil
FU U.S. Army Terrestrial Environmental Modeling and Intelligence System
(ARTEMIS) applied science research program - Assistant Secretary of the
Army for Acquisition, Logistics, and Technology (ASA-ALT); Cold Regions
Research and Engineering Laboratory (CRREL)
FX This work was supported by the U.S. Army Terrestrial Environmental
Modeling and Intelligence System (ARTEMIS) applied science research
program sponsored by the Assistant Secretary of the Army for
Acquisition, Logistics, and Technology (ASA-ALT) and by the Cold Regions
Research and Engineering Laboratory (CRREL). The MOD10A1 data product is
courtesy of the National Snow and Ice Data Center (NSIDC) Distributed
Active Archive Center (DAAC), NSIDC, Boulder, Colorado. The MOD09GA data
product is courtesy of the online Data Pool at the NASA Land Processes
(LP) DAAC, USGS/Earth Resources Observation and Science (EROS) Center,
Sioux Falls, South Dakota. Both the MOD09GA and MOD10A1 can be accessed
free-of-charge via NASA Earth Observing System Data and Information
System (EOSDIS) Reverb (http://reverb.echo.nasa.gov/reverb/). MODSCAG
data product is courtesy of the NASA Jet Propulsion Laboratory (JPL),
Pasadena, California.
NR 17
TC 2
Z9 2
U1 2
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0034-4257
EI 1879-0704
J9 REMOTE SENS ENVIRON
JI Remote Sens. Environ.
PD MAR 15
PY 2016
VL 175
BP 130
EP 137
DI 10.1016/j.rse.2015.12.030
PG 8
WC Environmental Sciences; Remote Sensing; Imaging Science & Photographic
Technology
SC Environmental Sciences & Ecology; Remote Sensing; Imaging Science &
Photographic Technology
GA DF0AC
UT WOS:000371000000011
ER
PT J
AU Moore, JD
Barnes, BC
Izvekov, S
Lisal, M
Sellers, MS
Taylor, DE
Brennan, JK
AF Moore, Joshua D.
Barnes, Brian C.
Izvekov, Sergei
Lisal, Martin
Sellers, Michael S.
Taylor, DeCarlos E.
Brennan, John K.
TI A coarse-grain force field for RDX: Density dependent and energy
conserving
SO JOURNAL OF CHEMICAL PHYSICS
LA English
DT Article
ID DISSIPATIVE PARTICLE DYNAMICS; CYCLOTRIMETHYLENE-TRINITRAMINE;
BIOMOLECULAR SYSTEMS; MOLECULAR-DYNAMICS; ELASTIC-CONSTANTS;
SIMULATIONS; CONSERVATION; POTENTIALS; PENTAERYTHRITOL; ALGORITHMS
AB We describe the development of a density-dependent transferable coarse-grain model of crystalline hexahydro-1,3,5-trinitro-s-triazine (RDX) that can be used with the energy conserving dissipative particle dynamics method. The model is an extension of a recently reported one-site model of RDX that was developed by using a force-matching method. The density-dependent forces in that original model are provided through an interpolation scheme that poorly conserves energy. The development of the new model presented in this work first involved a multi-objective procedure to improve the structural and thermodynamic properties of the previous model, followed by the inclusion of the density dependency via a conservative form of the force field that conserves energy. The new model accurately predicts the density, structure, pressure-volume isotherm, bulk modulus, and elastic constants of the RDX crystal at ambient pressure and exhibits transferability to a liquid phase at melt conditions. (C) 2016 AIP Publishing LLC.
C1 [Moore, Joshua D.; Barnes, Brian C.; Izvekov, Sergei; Sellers, Michael S.; Taylor, DeCarlos E.; Brennan, John K.] US Army, Energet Mat Sci Branch, RDRL WML B, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Lisal, Martin] Acad Sci Czech Republic, Inst Chem Proc Fundamentals, Vvi, Lab Aerosols Chem & Phys, CR-16502 Prague 6, Suchdol, Czech Republic.
[Lisal, Martin] Univ JE Purkyne, Inst Sci, Dept Phys, Usti Nad Labem 40096, Czech Republic.
RP Moore, JD (reprint author), US Army, Energet Mat Sci Branch, RDRL WML B, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RI Lisal, Martin/A-8176-2011
OI Lisal, Martin/0000-0001-8005-7143
FU Office of Naval Research; Department of Defense High Performance
Computing Modernization Program Software Application Institute for
Multiscale Reactive Modeling of Insensitive Munitions; ARL
[W911NF-10-2-0039]; Czech Science Foundation [13-02938S]
FX The authors would like to thank James Larentzos (Engility Corp.),
Jean-Bernard Maillet (Commissariat a l'energie atomique et aux energies
alternatives, DAM), Thomas D. Sewell (University of Missouri), and ARL
scientists William Mattson, Timothy Sirk, and Todd Beaudet for
insightful discussions. The authors acknowledge the computational
resources and PETTT software support from the High Performance Computing
Modernization office. J.D.M. and B.C.B. acknowledge support in part by
an appointment to the U.S. Army Research Laboratory Postdoctoral
Fellowship Program administered by the Oak Ridge Associated Universities
through a cooperative agreement with the U.S. Army Research Laboratory.
J.K.B. and J.D.M. acknowledge support in part by the Office of Naval
Research and the Department of Defense High Performance Computing
Modernization Program Software Application Institute for Multiscale
Reactive Modeling of Insensitive Munitions. M.L. acknowledges
sponsorship by the ARL under Cooperative Agreement No. W911NF-10-2-0039,
and the Czech Science Foundation under Project No. 13-02938S.
NR 66
TC 4
Z9 4
U1 7
U2 22
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0021-9606
EI 1089-7690
J9 J CHEM PHYS
JI J. Chem. Phys.
PD MAR 14
PY 2016
VL 144
IS 10
AR 104501
DI 10.1063/1.4942520
PG 11
WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical
SC Chemistry; Physics
GA DH7LE
UT WOS:000372974600019
PM 26979691
ER
PT J
AU Gardea, F
Glaz, B
Riddick, J
Lagoudas, DC
Naraghi, M
AF Gardea, Frank
Glaz, Bryan
Riddick, Jaret
Lagoudas, Dimitris C.
Naraghi, Mohammad
TI Identification of energy dissipation mechanisms in CNT-reinforced
nanocomposites
SO NANOTECHNOLOGY
LA English
DT Article
DE damping; nanocomposites; matrix plasticity; interfacial slip;
agglomeration
ID NANOTUBE-BASED COMPOSITES; SHEAR-LAG MODEL; POLYMER COMPOSITES; CARBON
NANOTUBES; ENHANCEMENT; MATRIX
AB In this paper we present our recent findings on the mechanisms of energy dissipation in polymerbased nanocomposites obtained through experimental investigations. The matrix of the nanocomposite was polystyrene (PS) which was reinforced with carbon nanotubes (CNTs). To study the mechanical strain energy dissipation of nanocomposites, we measured the ratio of loss to storage modulus for different CNT concentrations and alignments. CNT alignment was achieved via hot-drawing of PS-CNT. In addition, CNT agglomeration was studied via a combination of SEM imaging and Raman scanning. We found that at sufficiently low strains, energy dissipation in composites with high CNT alignment is not a function of applied strain, as no interfacial slip occurs between the CNTs and PS. However, below the interfacial slip strain threshold, damping scales monotonically with CNT content, which indicates the prevalence of CNT-CNT friction dissipation mechanisms within agglomerates. At higher strains, interfacial slip also contributes to energy dissipation. However, the increase in damping with strain, especially when CNT agglomerates are present, does not scale linearly with the effective interface area between CNTs and PS, suggesting a significant contribution of friction between CNTs within agglomerates to energy dissipation at large strains. In addition, for the first time, a comparison between the energy dissipation in randomly oriented and aligned CNT composites was made. It is inferred that matrix plasticity and tearing caused by misorientation of CNTs with the loading direction is a major cause of energy dissipation. The results of our research can be used to design composites with high energy dissipation capability, especially for applications where dynamic loading may compromise structural stability and functionality, such as rotary wing structures and antennas.
C1 [Gardea, Frank; Lagoudas, Dimitris C.; Naraghi, Mohammad] Texas A&M Univ, Dept Aerosp Engn, College Stn, TX 77843 USA.
[Glaz, Bryan; Riddick, Jaret] US Army Res Lab, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA.
RP Naraghi, M (reprint author), Texas A&M Univ, Dept Aerosp Engn, College Stn, TX 77843 USA.
EM Naraghi@tamu.edu
FU DOD-Army Research Laboratory [W911NF-14-2-0080]
FX The use of the Texas A & M University Materials Characterization
Facility is acknowledged. M N and D C L would like to acknowledge the
support of DOD-Army Research Laboratory, under the award No.
W911NF-14-2-0080.
NR 30
TC 2
Z9 2
U1 9
U2 33
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0957-4484
EI 1361-6528
J9 NANOTECHNOLOGY
JI Nanotechnology
PD MAR 11
PY 2016
VL 27
IS 10
AR 105707
DI 10.1088/0957-4484/27/10/105707
PG 9
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary;
Physics, Applied
SC Science & Technology - Other Topics; Materials Science; Physics
GA DD3US
UT WOS:000369849200019
PM 26866611
ER
PT J
AU Reish, ME
Zhang, Z
Ma, SL
Harrison, I
Everitt, HO
AF Reish, Matthew E.
Zhang, Zhen
Ma, Shiliang
Harrison, Ian
Everitt, Henry O.
TI How Annealing and Charge Scavengers Affect Visible Emission from ZnO
Nanocrystals
SO JOURNAL OF PHYSICAL CHEMISTRY C
LA English
DT Article
ID MICROCRYSTALLINE ZINC-OXIDE; OPTICAL-PROPERTIES; GREEN
PHOTOLUMINESCENCE; ELECTRONIC-STRUCTURE; COPPER IMPURITIES; PHOSPHOR
POWDERS; CONDUCTION-BAND; SPRAY-PYROLYSIS; UNDOPED ZNO; DEFECTS
AB Simultaneous transmission infrared (IR) absorption and photoluminescence (PL) spectroscopies are used to reveal the correlation of free electron and defect densities during the stepwise annealing of ZnO nanocrystals in high vacuum. For increasing annealing temperatures between 700 and 1000 K, the free electron density increases with a negligible increase in PL yield. With increased annealing temperature above 1000 K, the free electron density decreases and the PL yield increases in inverse proportion. Accompanying the free electron loss are indications of increased bound charges and changes in the multiphonon bands in the infrared spectrum, which collectively suggest that structural change and defect formation accompanies the loss of free electrons and the increase in PL. Exposure of the previously annealed sample to electron (02) and hole (MeOH) scavengers shows that the buildup of holes quenches visible emission, while additional electrons have a marginal effect on the PL yield. Given that certain neutral donors bind excitons and facilitate energy transfer to visible emitting sites, the buildup of free holes appears to quench PL intensity by ionizing those neutral donors.
C1 [Reish, Matthew E.; Zhang, Zhen; Ma, Shiliang; Harrison, Ian] Univ Virginia, Dept Chem, Charlottesville, VA 22904 USA.
[Everitt, Henry O.] US Army, Aviat & Missile RD&E Ctr, Redstone Arsenal, AL 35898 USA.
[Everitt, Henry O.] Duke Univ, Dept Phys, Durham, NC 27708 USA.
RP Everitt, HO (reprint author), US Army, Aviat & Missile RD&E Ctr, Redstone Arsenal, AL 35898 USA.
EM everitt@phy.duke.edu
RI Zhang, Zhen/C-6006-2008
OI Zhang, Zhen/0000-0001-6736-1677
FU Army Research Office [55748CH]; AES Corporation
FX The authors acknowledge the critical role John T. Yates played
encouraging and supporting the pursuit this project. The authors also
acknowledge helpful discussions with J. G. Simmons and J. V. Foreman. We
acknowledge with thanks the support of this work by the Army Research
Office under Grant 55748CH and the AES Corporation for a fellowship for
Shiliang Ma through the AES Graduate Fellowship in the Energy Research
Program at the University of Virginia.
NR 52
TC 0
Z9 0
U1 3
U2 10
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1932-7447
J9 J PHYS CHEM C
JI J. Phys. Chem. C
PD MAR 10
PY 2016
VL 120
IS 9
BP 5108
EP 5113
DI 10.1021/acs.jpcc.5b12094
PG 6
WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science,
Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA DG4LB
UT WOS:000372042600042
ER
PT J
AU Yu, SQ
Cai, YY
Lyons, C
Johnson, RF
Postnikova, E
Mazur, S
Johnson, JC
Radoshitzky, SR
Bailey, AL
Lauck, M
Goldberg, TL
O'Connor, DH
Jahrling, PB
Friedrich, TC
Kuhn, JH
AF Yu, Shuiqing
Cai, Yingyun
Lyons, Cassandra
Johnson, Reed F.
Postnikova, Elena
Mazur, Steven
Johnson, Joshua C.
Radoshitzky, Sheli R.
Bailey, Adam L.
Lauck, Michael
Goldberg, Tony L.
O'Connor, David H.
Jahrling, Peter B.
Friedrich, Thomas C.
Kuhn, Jens H.
TI Specific Detection of Two Divergent Simian Arteriviruses Using RNAscope
In Situ Hybridization
SO PLOS ONE
LA English
DT Article
ID RESPIRATORY-SYNDROME-VIRUS; HEMORRHAGIC-FEVER; MACAQUES; DISEASE;
TISSUES; RNA; CIRCOVIRUS; INFECTION
AB Simian hemorrhagic fever (SHF) is an often lethal disease of Asian macaques. Simian hemorrhagic fever virus (SHFV) is one of at least three distinct simian arteriviruses that can cause SHF, but pathogenesis studies using modern methods have been scarce. Even seemingly straightforward studies, such as examining viral tissue and cell tropism in vivo, have been difficult to conduct due to the absence of standardized SHFV-specific reagents. Here we report the establishment of an in situ hybridization assay for the detection of SHFV and distantly related Kibale red colobus virus 1 (KRCV-1) RNA in cell culture. In addition, we detected SHFV RNA in formalin-fixed, paraffin-embedded tissues from an infected rhesus monkey (Macaca mulatta). The assay is easily performed and can clearly distinguish between SHFV and KRCV-1. Thus, if further developed, this assay may be useful during future studies evaluating the mechanisms by which a simian arterivirus with a restricted cell tropism can cause a lethal nonhuman primate disease similar in clinical presentation to human viral hemorrhagic fevers.
C1 [Yu, Shuiqing; Cai, Yingyun; Lyons, Cassandra; Postnikova, Elena; Mazur, Steven; Johnson, Joshua C.; Jahrling, Peter B.; Kuhn, Jens H.] NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD USA.
[Johnson, Reed F.; Jahrling, Peter B.] NIAID, Emerging Infect Pathogens Sect, NIH, Frederick, MD USA.
[Radoshitzky, Sheli R.] US Army Med Res Inst Infect Dis, Frederick, MD USA.
[Bailey, Adam L.; Lauck, Michael; Goldberg, Tony L.; O'Connor, David H.; Friedrich, Thomas C.] Univ Wisconsin, Madison, WI USA.
RP Kuhn, JH (reprint author), NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD USA.
EM kuhnjens@mail.nih.gov
OI Friedrich, Thomas/0000-0001-9831-6895
FU Battelle Memorial Institute's prime contract the US National Institute
of Allergy and Infectious Diseases (NIAID) [HHSN272200700016I]; Battelle
Memorial Institute; Tunnell Government Services; MRIGlobal; NIAID
Division of Intramural Research; National Institutes of Health (NIH)
[TW009237, R01 AI077376]; Office of Research Infrastructure Programs
(ORIP) [P51OD011106]
FX The content of this publication does not necessarily reflect the views
or policies of the US Department of Defense, the US Department of Health
and Human Services, the US Department of the Army, or the institutions
and companies affiliated with the authors. This work was funded in part
through Battelle Memorial Institute's prime contract the US National
Institute of Allergy and Infectious Diseases (NIAID) under Contract No.
HHSN272200700016I (S.Y., Y.C., C.L., E.P., S.M., J.C.J., P.B.J.,
J.H.K.). S.Y. and J.C.J. performed this work as employees of Battelle
Memorial Institute. Subcontractors to Battelle Memorial Institute who
performed this work are: Y.C., C.L., E.P., and J.H.K, employees of
Tunnell Government Services, Inc.; and S.M., an employee of MRIGlobal.
Battelle Memorial Institute, Tunnell Government Services, and MRIGlobal
provided support in the form of salaries, but did not have any
additional role in the study design, data collection and analysis,
decision to publish, or preparation of the manuscript. All work under
contract HHSN272200700016I is performed under the
agreement/understanding that it will belong to the client and will be
affiliated directly to the NIH/NIAID Integrated Research Facility at
Fort Detrick. The specific roles of these authors are articulated in the
'author contributions' section. This work was also supported, in part,
by the NIAID Division of Intramural Research (R.F.J., P.B.J.), by
National Institutes of Health (NIH) grant TW009237 as part of the joint
NIH-NSF Ecology of Infectious Disease program, grant R01 AI077376, and
by the Office of Research Infrastructure Programs (ORIP) grant
P51OD011106 (A.L.B., M.L., T.L.G., D.H.O'C., T.C.F.). These funders did
not have any additional role in the study design, data collection and
analysis, decision to publish, or preparation of the manuscript.
NR 28
TC 0
Z9 0
U1 0
U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 10
PY 2016
VL 11
IS 3
AR e0151313
DI 10.1371/journal.pone.0151313
PG 9
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DG3TL
UT WOS:000371993000136
PM 26963736
ER
PT J
AU Ayangeakaa, AD
Janssens, RVF
Wu, CY
Allmond, JM
Wood, JL
Zhu, S
Albers, M
Almaraz-Calderon, S
Bucher, B
Carpenter, MP
Chiara, CJ
Cline, D
Crawford, HL
David, HM
Harker, J
Hayes, AB
Hoffman, CR
Kay, BP
Kolos, K
Korichi, A
Lauritsen, T
Macchiavelli, AO
Richard, A
Seweryniak, D
Wiens, A
AF Ayangeakaa, A. D.
Janssens, R. V. F.
Wu, C. Y.
Allmond, J. M.
Wood, J. L.
Zhu, S.
Albers, M.
Almaraz-Calderon, S.
Bucher, B.
Carpenter, M. P.
Chiara, C. J.
Cline, D.
Crawford, H. L.
David, H. M.
Harker, J.
Hayes, A. B.
Hoffman, C. R.
Kay, B. P.
Kolos, K.
Korichi, A.
Lauritsen, T.
Macchiavelli, A. O.
Richard, A.
Seweryniak, D.
Wiens, A.
TI Shape coexistence and the role of axial asymmetry in Ge-72
SO PHYSICS LETTERS B
LA English
DT Article
ID INTERACTING BOSON MODEL; COULOMB-EXCITATION; EXCITED-STATES;
ALPHA-DECAY; ATOMIC-NUCLEI; O+ STATES; ISOTOPES; NI-68; TRANSITION;
REGION
AB The quadrupole collectivity of low-lying states and the anomalous behavior of the 0(2)(+) and 2(3)(+) levels in Ge-72 are investigated via projectile multi-step Coulomb excitation with GRETINA and CHICO-2. Atotal of forty six E2 and M1 matrix elements connecting fourteen low-lying levels were determined using the least-squares search code, GOSIA. Evidence for triaxiality and shape coexistence, based on the model-independent shape invariants deduced from the Kumar-Cline sum rule, is presented. These are interpreted using a simple two-state mixing model as well as multi-state mixing calculations carried out within the framework of the triaxial rotor model. The results represent a significant milestone towards the understanding of the unusual structure of this nucleus. (C) 2016 The Authors. Published by Elsevier B.V.
C1 [Ayangeakaa, A. D.; Janssens, R. V. F.; Zhu, S.; Albers, M.; Almaraz-Calderon, S.; Carpenter, M. P.; Chiara, C. J.; David, H. M.; Harker, J.; Hoffman, C. R.; Kay, B. P.; Lauritsen, T.; Seweryniak, D.] Argonne Natl Lab, Div Phys, Argonne, IL 60439 USA.
[Wu, C. Y.; Bucher, B.] Lawrence Livermore Natl Lab, Livermore, CA 94550 USA.
[Allmond, J. M.] Oak Ridge Natl Lab, Div Phys, Oak Ridge, TN 37831 USA.
[Wood, J. L.] Georgia Inst Technol, Sch Phys, Atlanta, GA 30332 USA.
[Allmond, J. M.] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA.
[Cline, D.; Hayes, A. B.] Univ Rochester, Dept Phys & Astron, Rochester, NY 14627 USA.
[Crawford, H. L.; Richard, A.] Ohio Univ, Dept Phys & Astron, Inst Nucl & Particle Phys, Athens, OH 45701 USA.
[Kolos, K.] Univ Tennessee, Dept Phys & Astron, Knoxville, TN 37996 USA.
[Korichi, A.] CNRS, CSNSM, IN2P3, F-91405 Orsay, France.
[Korichi, A.] Univ Paris 11, F-91405 Orsay, France.
[Crawford, H. L.; Macchiavelli, A. O.; Wiens, A.] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Nucl Sci, 1 Cyclotron Rd, Berkeley, CA 94720 USA.
[Albers, M.] Ernst & Young GmbH, Mergenthalerallee 3-5, D-65760 Eschborn, Germany.
[Almaraz-Calderon, S.] Florida State Univ, Dept Phys, Tallahassee, FL 32306 USA.
[Chiara, C. J.] US Army Res Lab, Adelphi, MD 20783 USA.
[David, H. M.] Helmholtzzentrum Schwerionenforsch GmbH, GSI, D-64291 Darmstadt, Germany.
RP Ayangeakaa, AD (reprint author), Argonne Natl Lab, Div Phys, Argonne, IL 60439 USA.
EM ayangeakaa@anl.gov
RI Kay, Benjamin/F-3291-2011;
OI Kay, Benjamin/0000-0002-7438-0208; Ayangeakaa, Akaa
D./0000-0003-1679-3175
FU U.S. Department of Energy, Office of Science, Office of Nuclear Physics
[DE-AC02-06CH11357, DE-AC52-07NA27344, DE-FG02-94ER40834,
DE-FG0208ER41556]; National Science Foundation [0969079]
FX This material is based upon work supported by the U.S. Department of
Energy, Office of Science, Office of Nuclear Physics under Contract
numbers DE-AC02-06CH11357 and DE-AC52-07NA27344, and under Grant Numbers
DE-FG02-94ER40834 and DE-FG0208ER41556, and by the National Science
Foundation under grant number 0969079. This research used resources of
ANL's ATLAS facility, which is a DOE Office of Science User Facility.
NR 54
TC 4
Z9 4
U1 5
U2 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0370-2693
EI 1873-2445
J9 PHYS LETT B
JI Phys. Lett. B
PD MAR 10
PY 2016
VL 754
BP 254
EP 259
DI 10.1016/j.physletb.2016.01.036
PG 6
WC Astronomy & Astrophysics; Physics, Nuclear; Physics, Particles & Fields
SC Astronomy & Astrophysics; Physics
GA DD0HM
UT WOS:000369601000037
ER
PT J
AU Suchalkin, S
Ludwig, J
Belenky, G
Laikhtman, B
Kipshidze, G
Lin, Y
Shterengas, L
Smirnov, D
Luryi, S
Sarney, WL
Svensson, SP
AF Suchalkin, S.
Ludwig, J.
Belenky, G.
Laikhtman, B.
Kipshidze, G.
Lin, Y.
Shterengas, L.
Smirnov, D.
Luryi, S.
Sarney, W. L.
Svensson, S. P.
TI Electronic properties of unstrained unrelaxed narrow gap InAsx-Sb1-x
alloys
SO JOURNAL OF PHYSICS D-APPLIED PHYSICS
LA English
DT Article
DE narrow gap semiconductors; metamorphic materials; II-V semiconductors
ID BAND EFFECTIVE-MASS; INTERBAND MAGNETOABSORPTION; INFRARED DETECTORS;
INAS; INSB; ANTIMONIDE; INASXSB1-X; DISORDER; LAYERS; GASB
AB The electronic properties of unstrained unrelaxed InAsxSb1-x alloys have been determined in a wide range of alloy compositions using IR magnetospectroscopy, magnetotransport and IR photoluminescence, All studied alloys have n-type background doping with electron concentration decreasing with the Sb content, The composition dependence of the background doping concentration follows an empirical exponential law in a wide range of compositions. Both bandgap and electron effective mass dependence on alloy composition exhibit negative bowing reaching lowest values at X = 0,63: E-g = 0.10 eV, = 0,0082 m(0) at 4,2 K. The bowing coefficient of 0,038 m(0) obtained for the electron effective mass is in good agreement with that obtained from the Kane model.
C1 [Suchalkin, S.; Belenky, G.; Kipshidze, G.; Lin, Y.; Shterengas, L.; Luryi, S.] SUNY Stony Brook, Stony Brook, NY 11794 USA.
[Ludwig, J.; Smirnov, D.] Natl High Magnet Field Lab, Tallahassee, FL 32310 USA.
[Ludwig, J.] Florida State Univ, Tallahassee, FL 32306 USA.
[Laikhtman, B.] Hebrew Univ Jerusalem, Racah Inst Phys, IL-91904 Jerusalem, Israel.
[Sarney, W. L.; Svensson, S. P.] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
RP Suchalkin, S (reprint author), SUNY Stony Brook, Stony Brook, NY 11794 USA.
EM sergey.suchalkin@stonybrook.edu
FU US Army Research Office [W911NF1220057]; US National Science Foundation
[DMR1160843]; US Department of Energy, Office of Basic Energy Sciences
[DE-FG02-07ER46451]; National Science Foundation [DMR-1157490]; State of
Florida
FX The work was supported by US Army Research Office through award
W911NF1220057 and by the US National Science Foundation through grant
number DMR1160843. J L and D S acknowledge the support by the US
Department of Energy, Office of Basic Energy Sciences (Grant number
DE-FG02-07ER46451 for IR magnetospectroscopy and magnetotransport
experiments and data analysis. The CR and magnetotransport measurements
were performed at the National High Magnetic Field Laboratory, which is
supported by National Science Foundation Cooperative Agreement number
DMR-1157490 and the State of Florida.
NR 26
TC 2
Z9 2
U1 7
U2 19
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0022-3727
EI 1361-6463
J9 J PHYS D APPL PHYS
JI J. Phys. D-Appl. Phys.
PD MAR 9
PY 2016
VL 49
IS 10
DI 10.1088/0022-3727/49/10/105101
PG 6
WC Physics, Applied
SC Physics
GA DE7NM
UT WOS:000370824000005
ER
PT J
AU Gu, WT
Borodin, O
Zdyrko, B
Lin, HT
Kim, H
Nitta, N
Huang, JX
Magasinski, A
Milicev, Z
Berdichevsky, G
Yushin, G
AF Gu, Wentian
Borodin, Oleg
Zdyrko, Bogdan
Lin, Huan-Ting
Kim, Hyea
Nitta, Naoki
Huang, Jiaxin
Magasinski, Alexandre
Milicev, Zoran
Berdichevsky, Gene
Yushin, Gleb
TI Lithium-Iron Fluoride Battery with In Situ Surface Protection
SO ADVANCED FUNCTIONAL MATERIALS
LA English
DT Article
ID LI-ION BATTERIES; ORGANIC CARBONATE ELECTROLYTES; CONVERSION REACTION;
RECHARGEABLE BATTERIES; GRAPHITE-ELECTRODES; SULFUR BATTERIES; METAL
FLUORIDES; HF FORMATION; THIN-FILM; PERFORMANCE
AB Lithium-metal fluoride (MF) batteries offer the highest theoretical energy density, exceeding that of the sulfur-lithium cells. However, conversion-type MF cathodes suffer from high resistance, small capacity utilization at room temperature, irreversible structural changes, and rapid capacity fading with cycling. In this study, the successful application of the approach to overcome such limitations and dramatically enhance electrochemical performance of Li-MF cells is reported. By using iron fluoride (FeF2) as an example, Li-MF cells capable of achieving near-theoretical capacity utilization are shown when MF is infiltrated into the carbon mesopores. Most importantly, the ability of electrolytes based on the lithium bis(fluorosulfonyl)imide (LiFSI) salt is presented to successfully prevent the cathode dissolution and leaching via in situ formation of a Li ion permeable protective surface layer. This layer forms as a result of electrolyte reduction/oxidation reactions during the first cycle of the conversion reaction, thus minimizing the capacity losses during cycling. Postmortem analysis shows the absence of Li dendrites, which is important for safer use of Li metal anodes. As a result, Li-FeF2 cells demonstrate over 1000 stable cycles. Quantum chemistry calculations and post-mortem analysis provide insights into the mechanisms of the passivation layer formation and the performance boost.
C1 [Gu, Wentian; Lin, Huan-Ting; Nitta, Naoki; Huang, Jiaxin; Magasinski, Alexandre; Yushin, Gleb] Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA.
[Borodin, Oleg] Army Res Lab, Sensor & Elect Devices Directorate, Electrochem Branch, Adelphi, MD 20783 USA.
[Zdyrko, Bogdan; Kim, Hyea; Milicev, Zoran; Berdichevsky, Gene] Sila Nanotechnol Inc, Alameda, CA 94501 USA.
RP Yushin, G (reprint author), Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA.
EM yushin@gatech.edu
FU AFOSR [FA95500-13-1-0054]; DOE [DE-EE0006862]
FX Different aspects of this work were supported by AFOSR (grant
FA95500-13-1-0054) and DOE (grant DE-EE0006862). Modeling was supported
by ARL Enterprise on Multiscale Research.
NR 53
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U1 47
U2 134
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 1616-301X
EI 1616-3028
J9 ADV FUNCT MATER
JI Adv. Funct. Mater.
PD MAR 8
PY 2016
VL 26
IS 10
BP 1507
EP 1516
DI 10.1002/adfm.201504848
PG 10
WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied;
Physics, Condensed Matter
SC Chemistry; Science & Technology - Other Topics; Materials Science;
Physics
GA DG8CC
UT WOS:000372309000002
ER
PT J
AU Gong, P
Nan, XF
Barker, ND
Boyd, RE
Chen, YX
Wilkins, DE
Johnson, DR
Suedel, BC
Perkins, EJ
AF Gong, Ping
Nan, Xiaofei
Barker, Natalie D.
Boyd, Robert E.
Chen, Yixin
Wilkins, Dawn E.
Johnson, David R.
Suedel, Burton C.
Perkins, Edward J.
TI Predicting chemical bioavailability using microarray gene expression
data and regression modeling: A tale of three explosive compounds
SO BMC GENOMICS
LA English
DT Article
DE Tissue residue; Global gene expression profiling; Predictor genes;
Predictive regression modeling; TNT (2,4,6-Trinitrotoluene); RDX
(1,3,5-Trinitro-1,3,5-triazacyclohexane); HMX
(Octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine); Earthworm (Eisenia
fetida)
ID QUANTITATIVE PREDICTION; CANCER; CLASSIFICATION; ASSOCIATION;
ANNOTATION; SELECTION; MARKERS; TRAITS
AB Background: Chemical bioavailability is an important dose metric in environmental risk assessment. Although many approaches have been used to evaluate bioavailability, not a single approach is free from limitations. Previously, we developed a new genomics-based approach that integrated microarray technology and regression modeling for predicting bioavailability (tissue residue) of explosives compounds in exposed earthworms. In the present study, we further compared 18 different regression models and performed variable selection simultaneously with parameter estimation.
Results: This refined approach was applied to both previously collected and newly acquired earthworm microarray gene expression datasets for three explosive compounds. Our results demonstrate that a prediction accuracy of R-2 = 0.71-0.82 was achievable at a relatively low model complexity with as few as 3-10 predictor genes per model. These results are much more encouraging than our previous ones.
Conclusion: This study has demonstrated that our approach is promising for bioavailability measurement, which warrants further studies of mixed contamination scenarios in field settings
C1 [Gong, Ping; Boyd, Robert E.; Suedel, Burton C.; Perkins, Edward J.] US Army, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Nan, Xiaofei; Chen, Yixin; Wilkins, Dawn E.] Univ Mississippi, Dept Comp & Informat Sci, Oxford, MS 38677 USA.
[Barker, Natalie D.] Bennett Aerosp Inc, Cary, NC 27518 USA.
[Johnson, David R.] GHD, Dallas, TX 75234 USA.
[Nan, Xiaofei] Zhengzhou Univ, Sch Informat Engn, Zhengzhou 450001, Henan, Peoples R China.
RP Gong, P (reprint author), US Army, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
EM ping.gong@usace.army.mil
FU U.S. Army Environmental Quality/Installation Technology Research Program
as part of project "Toxicogenomics for Assessment of Munitions and
Explosives Related Compounds"; U.S. National Science Foundation [EPS
0903787]; U.S. Army Environmental Quality/Installation Technology
Research Program as part of project "Impact of Munitions Constituents on
Biological Networks"
FX This work was funded by the U.S. Army Environmental Quality/Installation
Technology Research Program as part of projects "Toxicogenomics for
Assessment of Munitions and Explosives Related Compounds" and "Impact of
Munitions Constituents on Biological Networks". Drs. X. Nan, Y. Chen and
D. Wilkins were supported in part by the U.S. National Science
Foundation under award number EPS 0903787. We thank Dr. Guilherme R.
Lotufo of U.S. Army Corps of Engineers for his suggestion of using
ScintiGest solubilizer for tissue digestion, and A. E. Elaine van Ommen
Kloeke of VU University Amsterdam for sharing Blast2Go annotations of
earthworm transcriptome. Permission to publish this information was
granted by the Chief of Engineers.
NR 27
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Z9 0
U1 7
U2 10
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2164
J9 BMC GENOMICS
JI BMC Genomics
PD MAR 8
PY 2016
VL 17
AR 205
DI 10.1186/s12864-016-2541-5
PG 10
WC Biotechnology & Applied Microbiology; Genetics & Heredity
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA DF8GO
UT WOS:000371595700010
PM 26956490
ER
PT J
AU Crowell, TA
Ganesan, A
Berry, SA
Deiss, RG
Agan, BK
Okulicz, JF
AF Crowell, Trevor A.
Ganesan, Anuradha
Berry, Stephen A.
Deiss, Robert G.
Agan, Brian K.
Okulicz, Jason F.
CA Infect Dis Clinical Res Program ID
TI Hospitalizations among HIV controllers and persons with medically
controlled HIV in the US Military HIV Natural History Study
SO JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
LA English
DT Article
DE HIV; HIV non-progressors; patient admission; hospitalization; highly
active antiretroviral therapy
ID T-CELL-ACTIVATION; LOW-LEVEL VIREMIA; ANTIRETROVIRAL THERAPY; ELITE
CONTROLLERS; HEPATITIS COINFECTION; IMMUNE ACTIVATION; VIRAL
REPLICATION; UNITED-STATES; HEALTH-CARE; INFECTION
AB Introduction: HIV controllers (HICs) experience relatively low-level viraemia and CD4 preservation without antiretroviral therapy (ART), but also immune activation that may predispose to adverse clinical events such as cardiovascular disease and hospitalization. The objective of this study was to characterize the rates and reasons for hospitalization among HICs and persons with medically controlled HIV.
Methods: Subjects with consistently well-controlled HIV were identified in the U.S. Military HIV Natural History Study. ART prescription and HIV-1 RNA data were used to categorize subjects as HICs or medically controlled as defined by >= 3 HIV-1 RNA measurements <= 2000 or <= 400 copies/mL, respectively, representing the majority of measurements spanning >= 12 months. Hospitalizations were tallied and assigned diagnostic categories. All-cause hospitalization rates were compared between groups using negative binomial regression.
Results and discussion: Of 3106 subjects followed from 2000 to 2013, 221 were HICs, including 33 elite (1.1%) and 188 viraemic (6.0%) controllers, who contributed 882 person-years (PY) of observation time. An additional 870 subjects with medically controlled HIV contributed 4217 PY. Mean hospitalization rates were 9.4/100 PY among HICs and 8.8/100 PY among medically controlled subjects. Non-AIDS-defining infections were the most common reason for hospitalization (2.95/100 PY and 2.70/100 PY, respectively) and rates of cardiovascular hospitalization were similar in both groups (0.45/100 PY and 0.76/100 PY). There was no difference in hospitalization rate for HICs compared with subjects with medically controlled HIV (adjusted incidence rate ratio 1.15 [95% confidence interval 0.80 to 1.65]).
Conclusions: All-cause and cardiovascular hospitalization rates did not differ between HICs and persons with medically controlled HIV. Non-AIDS defining infections were common in this young, healthy, predominantly male cohort of military personnel and beneficiaries.
C1 [Okulicz, Jason F.] San Antonio Mil Med Ctr, Infect Dis Serv, 3551 Roger Brooke Dr, San Antonio, TX 78234 USA.
[Crowell, Trevor A.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
[Crowell, Trevor A.; Ganesan, Anuradha; Deiss, Robert G.; Agan, Brian K.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
[Ganesan, Anuradha] Walter Reed Natl Mil Med Ctr, Infect Dis Serv, Bethesda, MD USA.
[Ganesan, Anuradha; Deiss, Robert G.; Agan, Brian K.; Okulicz, Jason F.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biostat, Infect Dis Clin Res Program, Bethesda, MD 20814 USA.
[Berry, Stephen A.] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA.
[Deiss, Robert G.] Naval Med Ctr San Diego, Infect Dis Clin, San Diego, CA USA.
RP Crowell, TA (reprint author), US Mil HIV Res Program, 6720 A Rockledge Dr,Suite 400, Bethesda, MD 20817 USA.; Okulicz, JF (reprint author), San Antonio Mil Med Ctr, Infect Dis Serv, 3551 Roger Brooke Dr, San Antonio, TX 78234 USA.
EM tcrowell@hivresearch.org; jason.f.okulicz.mil@mail.mil
OI Agan, Brian/0000-0002-5114-1669
FU Infectious Disease Clinical Research Program (IDCRP) [IDCRP-000-05];
Department of Defense (DoD) program executed through the Uniformed
Services University of the Health Sciences; National Institute of
Allergy and Infectious Diseases (NIAID)/National Institutes of Health
(NIH) [Y1-AI-5072]; Henry M. Jackson Foundation for the Advancement of
Military Medicine, Inc.; DoD [W81XWH-07-2-0067]; NIAID/NIH [K23AI084854]
FX Support for this work (IDCRP-000-05) was provided by the Infectious
Disease Clinical Research Program (IDCRP), a Department of Defense (DoD)
program executed through the Uniformed Services University of the Health
Sciences. This project has been funded in whole, or in part, with
federal funds from the National Institute of Allergy and Infectious
Diseases (NIAID)/National Institutes of Health (NIH), under Inter-Agency
Agreement Y1-AI-5072; a cooperative agreement between the Henry M.
Jackson Foundation for the Advancement of Military Medicine, Inc., and
the DoD (W81XWH-07-2-0067); a grant to S.A.B. from NIAID/NIH
(K23AI084854).
NR 34
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Z9 1
U1 1
U2 4
PU INT AIDS SOCIETY
PI GENEVA
PA AVENUE DE FRANCE 23, GENEVA, 1202, SWITZERLAND
SN 1758-2652
J9 J INT AIDS SOC
JI J. Int. AIDS Soc.
PD MAR 7
PY 2016
VL 19
AR 20524
DI 10.7448/IAS.19.1.20524
PG 6
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA DM2JG
UT WOS:000376172300001
PM 26955965
ER
PT J
AU Chau, N
Slipher, GA
O'Brien, BM
Mrozek, RA
Anderson, IA
AF Chau, Nixon
Slipher, Geoffrey A.
O'Brien, Benjamin M.
Mrozek, Randy A.
Anderson, Iain A.
TI A solid-state dielectric elastomer switch for soft logic
SO APPLIED PHYSICS LETTERS
LA English
DT Article
ID ACTUATORS; PERCOLATION
AB In this paper, we describe a stretchable solid-state electronic switching material that operates at high voltage potentials, as well as a switch material benchmarking technique that utilizes a modular dielectric elastomer (artificial muscle) ring oscillator. The solid-state switching material was integrated into our oscillator, which self-started after 16 s and performed 5 oscillations at a frequency of 1.05 Hz with 3.25 kV DC input. Our materials-by-design approach for the nickel filled polydimethylsiloxane based switch has resulted in significant improvements over previous carbon grease-based switches in four key areas, namely, sharpness of switching behavior upon applied stretch, magnitude of electrical resistance change, ease of manufacture, and production rate. Switch lifetime was demonstrated to be in the range of tens to hundreds of cycles with the current process. An interesting and potentially useful strain-based switching hysteresis behavior is also presented. (C) 2016 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
C1 [Chau, Nixon; Anderson, Iain A.] Univ Auckland, Auckland Bioengn Inst, Biomimet Lab, Level 6,70 Symonds St, Auckland 1010, New Zealand.
[Slipher, Geoffrey A.; Mrozek, Randy A.] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
[O'Brien, Benjamin M.; Anderson, Iain A.] StretchSense Ltd, 27 Walls Rd, Auckland 1061, New Zealand.
[Anderson, Iain A.] Univ Auckland, Sch Engn, Dept Engn Sci, Level 3,70 Symonds St, Auckland 1010, New Zealand.
RP Slipher, GA (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM geoffrey.a.slipher.civ@mail.mil
OI Slipher, Geoffrey/0000-0003-0532-0081
FU U.S. Army International Technology Center, Pacific (USAITC-Pac)
[FA5209-14-P-0016]
FX N.C. and I.A. acknowledge the U.S. Army International Technology Center,
Pacific (USAITC-Pac) for providing funding for the work performed at the
University of Auckland under Grant No. FA5209-14-P-0016.
NR 19
TC 2
Z9 2
U1 6
U2 12
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0003-6951
EI 1077-3118
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD MAR 7
PY 2016
VL 108
IS 10
AR 103506
DI 10.1063/1.4943628
PG 5
WC Physics, Applied
SC Physics
GA DH7KV
UT WOS:000372973600051
ER
PT J
AU Amato, R
Miotto, O
Woodrow, CJ
Almagro-Garcia, J
Sinha, I
Campino, S
Mead, D
Drury, E
Kekre, M
Sanders, M
Amambua-Ngwa, A
Amaratunga, C
Amenga-Etego, L
Andrianaranjaka, V
Apinjoh, T
Ashley, E
Auburn, S
Awandare, GA
Baraka, V
Barry, A
Boni, MF
Borrmann, S
Bousema, T
Branch, O
Bull, PC
Chotivanich, K
Conway, DJ
Craig, A
Day, NP
Djimde, A
Dolecek, C
Dondorp, AM
Drakeley, C
Duffy, P
Echeverry, DF
Egwang, TG
Fairhurst, RM
Faiz, MA
Fanello, CI
Hien, TT
Hodgson, A
Imwong, M
Ishengoma, D
Lim, P
Lon, C
Marfurt, J
Marsh, K
Mayxay, M
Michon, P
Mobegi, V
Mokuolu, OA
Montgomery, J
Mueller, I
Kyaw, MP
Newton, PN
Nosten, F
Noviyanti, R
Nzila, A
Ocholla, H
Oduro, A
Onyamboko, M
Ouedraogo, JB
Phyo, APP
Plowe, C
Price, RN
Pukrittayakamee, S
Randrianarivelojosia, M
Ringwald, P
Ruiz, L
Saunders, D
Shayo, A
Siba, P
Takala-Harrison, S
Thanh, TNN
Thathy, V
Verra, F
Wendler, J
White, NJ
Ye, H
Cornelius, VJ
Giacomantonio, R
Muddyman, D
Henrichs, C
Malangone, C
Jyothi, D
Pearson, RD
Rayner, JC
McVean, G
Rockett, KA
Miles, A
Vauterin, P
Jeffery, B
Manske, M
Stalker, J
Maclnnis, B
Kwiatkowski, DP
AF Amato, Roberto
Miotto, Olivo
Woodrow, Charles J.
Almagro-Garcia, Jacob
Sinha, Ipsita
Campino, Susana
Mead, Daniel
Drury, Eleanor
Kekre, Mihir
Sanders, Mandy
Amambua-Ngwa, Alfred
Amaratunga, Chanaki
Amenga-Etego, Lucas
Andrianaranjaka, Voahangy
Apinjoh, Tobias
Ashley, Elizabeth
Auburn, Sarah
Awandare, Gordon A.
Baraka, Vito
Barry, Alyssa
Boni, Maciej F.
Borrmann, Steffen
Bousema, Teun
Branch, Oralee
Bull, Peter C.
Chotivanich, Kesinee
Conway, David J.
Craig, Alister
Day, Nicholas P.
Djimde, Abdoulaye
Dolecek, Christiane
Dondorp, Arjen M.
Drakeley, Chris
Duffy, Patrick
Echeverry, Diego F.
Egwang, Thomas G.
Fairhurst, Rick M.
Faiz, Md. Abul
Fanello, Caterina I.
Tran Tinh Hien
Hodgson, Abraham
Imwong, Mallika
Ishengoma, Deus
Lim, Pharath
Lon, Chanthap
Marfurt, Jutta
Marsh, Kevin
Mayxay, Mayfong
Michon, Pascal
Mobegi, Victor
Mokuolu, Olugbenga A.
Montgomery, Jacqui
Mueller, Ivo
Kyaw, Myat Phone
Newton, Paul N.
Nosten, Francois
Noviyanti, Rintis
Nzila, Alexis
Ocholla, Harold
Oduro, Abraham
Onyamboko, Marie
Ouedraogo, Jean-Bosco
Phyo, Aung Pyae P.
Plowe, Christopher
Price, Ric N.
Pukrittayakamee, Sasithon
Randrianarivelojosia, Milijaona
Ringwald, Pascal
Ruiz, Lastenia
Saunders, David
Shayo, Alex
Siba, Peter
Takala-Harrison, Shannon
Thanh, Thuy-Nhien N.
Thathy, Vandana
Verra, Federica
Wendler, Jason
White, Nicholas J.
Ye, Htut
Cornelius, Victoria J.
Giacomantonio, Rachel
Muddyman, Dawn
Henrichs, Christa
Malangone, Cinzia
Jyothi, Dushyanth
Pearson, Richard D.
Rayner, Julian C.
McVean, Gilean
Rockett, Kirk A.
Miles, Alistair
Vauterin, Paul
Jeffery, Ben
Manske, Magnus
Stalker, Jim
Maclnnis, Bronwyn
Kwiatkowski, Dominic P.
CA MalariaGEN Plasmodium Falciparum C
TI Genomic epidemiology of artemisinin resistant malaria
SO ELIFE
LA English
DT Article
ID PLASMODIUM-FALCIPARUM MALARIA; MOLECULAR POPULATION-GENETICS; SOFT
SELECTIVE SWEEPS; SUB-SAHARAN AFRICA; SUBSTITUTION MATRICES;
DRUG-RESISTANCE; ADAPTATION; MUTATIONS; EVOLUTION; CAMBODIA
AB The current epidemic of artemisinin resistant Plasmodium falciparum in Southeast Asia is the result of a soft selective sweep involving at least 20 independent kelch13 mutations. In a large global survey, we find that kelchl3 mutations which cause resistance in Southeast Asia are present at low frequency in Africa. We show that African kelch13 mutations have originated locally, and that kelch13 shows a normal variation pattern relative to other genes in Africa, whereas in Southeast Asia there is a great excess of non-synonymous mutations, many of which cause radical amino-acid changes. Thus, kelch13 is not currently undergoing strong selection in Africa, despite a deep reservoir of variations that could potentially allow resistance to emerge rapidly. The practical implications are that public health surveillance for artemisinin resistance should not rely on kelchl3 data alone, and interventions to prevent resistance must account for local evolutionary conditions, shown by genomic epidemiology to differ greatly between geographical regions.
C1 [Amato, Roberto; Miotto, Olivo; Almagro-Garcia, Jacob; Campino, Susana; Mead, Daniel; Drury, Eleanor; Kekre, Mihir; Sanders, Mandy; Giacomantonio, Rachel; Muddyman, Dawn; Malangone, Cinzia; Jyothi, Dushyanth; Pearson, Richard D.; Rayner, Julian C.; Rockett, Kirk A.; Miles, Alistair; Manske, Magnus; Stalker, Jim; Maclnnis, Bronwyn; Kwiatkowski, Dominic P.] Wellcome Trust Sanger Inst, Cambridge, England.
[Amato, Roberto; Miotto, Olivo; Almagro-Garcia, Jacob; Wendler, Jason; Cornelius, Victoria J.; Giacomantonio, Rachel; Henrichs, Christa; Pearson, Richard D.; McVean, Gilean; Rockett, Kirk A.; Miles, Alistair; Vauterin, Paul; Jeffery, Ben; Kwiatkowski, Dominic P.] Wellcome Trust Ctr Human Genet, Ctr Genom & Global Hlth, Oxford, England.
[Miotto, Olivo; Woodrow, Charles J.; Sinha, Ipsita; Ashley, Elizabeth; Day, Nicholas P.; Dondorp, Arjen M.; Fanello, Caterina I.; Imwong, Mallika; White, Nicholas J.] Mahidol Univ, Mahidol Oxford Trop Med Res Unit, Bangkok 10700, Thailand.
[Woodrow, Charles J.; Boni, Maciej F.; Bull, Peter C.; Day, Nicholas P.; Dolecek, Christiane; Dondorp, Arjen M.; Tran Tinh Hien; Price, Ric N.; Thanh, Thuy-Nhien N.; White, Nicholas J.] Univ Oxford, Nuffield Dept Med, Ctr Trop Med & Global Hlth, Oxford, England.
[Amambua-Ngwa, Alfred; Conway, David J.; Mobegi, Victor] MRC Unit, Banjul, Gambia.
[Amaratunga, Chanaki; Duffy, Patrick; Fairhurst, Rick M.; Lim, Pharath] NIAID, NIH, Rockville, MD USA.
[Amenga-Etego, Lucas; Tran Tinh Hien; Oduro, Abraham] Navrongo Hlth Res Ctr, Navrongo, Ghana.
[Andrianaranjaka, Voahangy; Randrianarivelojosia, Milijaona] Inst Pasteur Madagascar, Malaria Res Unit, Antananarivo, Madagascar.
[Apinjoh, Tobias] Univ Buea, Buea, Cameroon.
[Auburn, Sarah; Marfurt, Jutta; Price, Ric N.] Menzies Sch Hlth Res, Global & Trop Hlth Div, Darwin, NT, Australia.
[Auburn, Sarah; Marfurt, Jutta; Price, Ric N.] Charles Darwin Univ, Darwin, NT 0909, Australia.
[Awandare, Gordon A.] Univ Ghana, Coll Basic & Appl Sci, West African Ctr Cell Biol Infect Pathogens, Legon, Ghana.
[Baraka, Vito; Ishengoma, Deus] Natl Inst Med Res, Tanga Ctr, Tanga, Tanzania.
[Baraka, Vito] Univ Antwerp, Dept Epidemiol, Int Hlth Unit, B-2020 Antwerp, Belgium.
[Barry, Alyssa] Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Populat Hlth & Immun, Parkville, Vic 3050, Australia.
[Barry, Alyssa; Mueller, Ivo] Univ Melbourne, Dept Med Biol, Carlton, Vic 3053, Australia.
[Boni, Maciej F.] Univ Oxford, Ho Chi Minh City, Vietnam.
[Borrmann, Steffen; Bull, Peter C.; Marsh, Kevin; Thathy, Vandana] Wellcome Trust Collaborat Res Program, Kenya Med Res Inst, Kilifi, Kenya.
[Borrmann, Steffen] Univ Tubingen, Inst Trop Med, Tubingen, Germany.
[Bousema, Teun; Conway, David J.; Drakeley, Chris; Mobegi, Victor; Verra, Federica] London Sch Hyg & Trop Med, London WC1, England.
[Branch, Oralee] NYU, Sch Med, New York, NY USA.
[Chotivanich, Kesinee; Pukrittayakamee, Sasithon] Mahidol Univ, Fac Trop Med, Bangkok, Thailand.
[Craig, Alister] Univ Liverpool, Liverpool Sch Trop Med, Liverpool L3 5QA, Merseyside, England.
[Djimde, Abdoulaye] Univ Bamako, Fac Med, Malaria Res & Training Ctr, Bamako, Mali.
[Dolecek, Christiane; Tran Tinh Hien; Thanh, Thuy-Nhien N.] Univ Oxford, Clin Res Unit, Ho Chi Minh City, Vietnam.
[Echeverry, Diego F.] Purdue Univ, Dept Entomol, W Lafayette, IN 47907 USA.
[Echeverry, Diego F.] CIDEIM, Int Ctr Med Res & Training, Cali, Colombia.
[Egwang, Thomas G.] Med Biotech Labs, Kampala, Uganda.
[Faiz, Md. Abul] Malaria Res Grp, Dhaka, Bangladesh.
[Faiz, Md. Abul] Dev Care Fdn, Dhaka, Bangladesh.
[Lim, Pharath] Natl Ctr Parasitol Entomol & Malaria Control, Phnom Penh, Cambodia.
[Lon, Chanthap; Saunders, David] Armed Forces Res Inst Med Sci, US Army Med Component, Dept Immunol & Med, Bangkok 10400, Thailand.
[Mayxay, Mayfong; Newton, Paul N.] Lao Oxford Mahosot Hosp Wellcome Trust Res Unit, Vientiane, Lao PDR, England.
[Mayxay, Mayfong] Univ Hlth Sci, Fac Postgrad Studies, Vientiane, Lao PDR, England.
[Michon, Pascal] Divine Word Univ, Fac Med & Hlth Sci, Madang, Papua N Guinea.
[Mokuolu, Olugbenga A.] Univ Ilorin, Dept Paediat & Child Hlth, Ilorin, Nigeria.
[Montgomery, Jacqui] Penn State Univ, Dept Biol & Entomol, University Pk, PA 16802 USA.
[Kyaw, Myat Phone; Ye, Htut] Minist Hlth, Dept Med Res Lower Myanmar, Yangon, Myanmar.
[Nosten, Francois] Mahidol Univ, Mahido Oxford Trop Med Res Unit, Mae Sot, Thailand.
[Nosten, Francois; Phyo, Aung Pyae P.] Shoklo Malaria Res Unit, Mae Sot, Thailand.
[Noviyanti, Rintis] Eijkman Inst Mol Biol, Jakarta, Indonesia.
[Nzila, Alexis] King Fahd Univ Petr & Minerals, Dept Biol, Dhahran, Saudi Arabia.
[Ocholla, Harold] Malawi Liverpool Wellcome Trust Clin Res Programm, Lilongwe, Malawi.
[Onyamboko, Marie] Univ Kinshasa, Kinshasa, Zaire.
[Ouedraogo, Jean-Bosco] Direct Regionale Ouest, Inst Rech Sci Sante, Bobo Dioulasso, Burkina Faso.
[Phyo, Aung Pyae P.] Shoklo Malaria Res Unit, Bangkok, Thailand.
[Plowe, Christopher; Takala-Harrison, Shannon] Univ Maryland, Sch Med, Inst Global Hlth, Baltimore, MD 21201 USA.
[Ringwald, Pascal] WHO, Global Malaria Programme, CH-1211 Geneva, Switzerland.
[Ruiz, Lastenia] Univ Nacl Amazonia Peruana, Iquitos, Peru.
[Shayo, Alex] Univ Dodoma, Dept Biotechnol & Bioinformat, Dodoma, Tanzania.
[Siba, Peter] Papua New Guinea Inst Med Res, Madang, Papua N Guinea.
RP Amato, R; Miotto, O; Kwiatkowski, DP (reprint author), Wellcome Trust Sanger Inst, Cambridge, England.; Amato, R; Miotto, O; Kwiatkowski, DP (reprint author), Wellcome Trust Ctr Human Genet, Ctr Genom & Global Hlth, Oxford, England.; Miotto, O (reprint author), Mahidol Univ, Mahidol Oxford Trop Med Res Unit, Bangkok 10700, Thailand.
EM ra4@sanger.ac.uk; olivo@tropmedres.ac; dominic@sanger.ac.uk
RI Bousema, Teun/N-3574-2014;
OI Pyae Phyo, Aung/0000-0002-0383-9624; Miotto, Olivo/0000-0001-8060-6771;
Mead, Daniel/0000-0001-7717-4330; Baraka, Vito /0000-0001-9694-9293;
Conway, David/0000-0002-8711-3037; Craig, Alister/0000-0003-0914-6164;
Jyothi, Dushyanth/0000-0002-0448-5303; Auburn,
Sarah/0000-0002-4638-536X; Price, Richard/0000-0003-2000-2874; Rayner,
Julian/0000-0002-9835-1014; Awandare, Gordon/0000-0002-8793-3641;
Kwiatkowski, Dominic/0000-0002-5023-0176; Manske,
Magnus/0000-0001-5916-0947
FU Wellcome Trust [98051, 090532/Z/09/Z, 90770, 0892375/H/09/Z]; Medical
Research Council [G0600718]; Bill and Melinda Gates Foundation
[OPP1040463]; National Institute of Allergy and Infectious Diseases
FX Wellcome Trust WT Sanger Institute Core Funding, 98051 Roberto Amato
Susana Campino Daniel Mead Eleanor Drury Mihir Kekre Mandy Sanders
Victoria J Cornelius Rachel Giacomantonio Dawn Muddyman Cinzia Malangone
Dushyanth Jyothi Richard D Pearson Julian C Rayner Kirk A Rockett
Alistair Miles Heinrich M Manske Jim Stalker Bronwyn MacInnis Dominic P
Kwiatkowski; Wellcome Trust WT Centre for Human Genetics Core Funding,
090532/Z/09/Z Roberto Amato Jacob Almagro-Garcia Victoria J Cornelius
Rachel Giacomantonio Christa Henrichs Richard D Pearson Gilean McVean
Kirk A Rockett Alistair Miles Paul Vauterin Ben Jeffery Dominic P
Kwiatkowski; Wellcome Trust WT Stategic Award, 90770 Roberto Amato Olivo
Miotto Jacob Almagro-Garcia Susana Campino Daniel Mead Eleanor Drury
Mihir Kekre Lucas Amenga-Etego Tobias Apinjoh Abdoulaye Djimde Deus
Ishengoma Milijaona Randrianarivelojosia Victoria J Cornelius Rachel
Giacomantonio Dawn Muddyman Christa Henrichs Cinzia Malangone Dushyanth
Jyothi Richard D Pearson Kirk A Rockett Alistair Miles Paul Vauterin Ben
Jeffery Heinrich M Manske Jim Stalker Bronwyn MacInnis Dominic P
Kwiatkowski; Medical Research Council Centre for Genomics and Global
Health, G0600718 Roberto Amato Olivo Miotto Jacob Almagro-Garcia Lucas
Amenga-Etego Tobias Apinjoh Abdoulaye Djimde Deus Ishengoma Victoria J
Cornelius Rachel Giacomantonio Dawn Muddyman Gilean McVean Kirk A
Rockett Alistair Miles Paul Vauterin Ben Jeffery Heinrich M Manske Jim
Stalker Bronwyn MacInnis Dominic P Kwiatkowski; Bill and Melinda Gates
Foundation Grant OPP1040463 Roberto Amato Olivo Miotto Charles J Woodrow
Ipsita Sinha Elizabeth Ashley Nicholas P Day Arjen M Dondorp Mallika
Imwong Nicholas J White Dominic P Kwiatkowski; Wellcome Trust WT Mahidol
University Oxford Tropical Medicine Research Programme, 0892375/H/09/Z
Olivo Miotto Charles J Woodrow Ipsita Sinha Elizabeth Ashley Nicholas P
Day Arjen M Dondorp Caterina I Fanello Mayfong Mayxay Paul N Newton
Francois Nosten Nicholas J White; National Institute of Allergy and
Infectious Diseases Intramural Research Program Chanaki Amaratunga Rick
M Fairhurst Pharath Lim
NR 53
TC 2
Z9 3
U1 7
U2 19
PU ELIFE SCIENCES PUBLICATIONS LTD
PI CAMBRIDGE
PA SHERATON HOUSE, CASTLE PARK, CAMBRIDGE, CB3 0AX, ENGLAND
SN 2050-084X
J9 ELIFE
JI eLife
PD MAR 4
PY 2016
VL 5
AR e08714
DI 10.7554/eLife.08714
PG 29
WC Biology
SC Life Sciences & Biomedicine - Other Topics
GA DG2IH
UT WOS:000371890100001
ER
PT J
AU Bornholdt, ZA
Turner, HL
Murin, CD
Li, W
Sok, D
Souders, CA
Piper, AE
Goff, A
Shamblin, JD
Wollen, SE
Sprague, TR
Fusco, ML
Pommert, KBJ
Cavacini, LA
Smith, HL
Klempner, M
Reimann, KA
Krauland, E
Gerngross, TU
Wittrup, KD
Saphire, EO
Burton, DR
Glass, PJ
Ward, AB
Walker, LM
AF Bornholdt, Zachary A.
Turner, Hannah L.
Murin, Charles D.
Li, Wen
Sok, Devin
Souders, Colby A.
Piper, Ashley E.
Goff, Arthur
Shamblin, Joshua D.
Wollen, Suzanne E.
Sprague, Thomas R.
Fusco, Marnie L.
Pommert, Kathleen B. J.
Cavacini, Lisa A.
Smith, Heidi L.
Klempner, Mark
Reimann, Keith A.
Krauland, Eric
Gerngross, Tillman U.
Wittrup, Karl D.
Saphire, Erica Ollmann
Burton, Dennis R.
Glass, Pamela J.
Ward, Andrew B.
Walker, Laura M.
TI Isolation of potent neutralizing antibodies from a survivor of the 2014
Ebola virus outbreak
SO SCIENCE
LA English
DT Article
ID MONOCLONAL-ANTIBODIES; NONHUMAN-PRIMATES; B-CELLS; INFECTION;
REARRANGEMENTS; SELECTION; MACAQUES; COCKTAIL; DISEASE
AB Antibodies targeting the Ebola virus surface glycoprotein (EBOV GP) are implicated in protection against lethal disease, but the characteristics of the human antibody response to EBOV GP remain poorly understood. We isolated and characterized 349 GP-specific monoclonal antibodies (mAbs) from the peripheral B cells of a convalescent donor who survived the 2014 EBOV Zaire outbreak. Remarkably, 77% of the mAbs neutralize live EBOV, and several mAbs exhibit unprecedented potency. Structures of selected mAbs in complex with GP reveal a site of vulnerability located in the GP stalk region proximal to the viral membrane. Neutralizing antibodies targeting this site show potent therapeutic efficacy against lethal EBOV challenge in mice. The results provide a framework for the design of new EBOV vaccine candidates and immunotherapies.
C1 [Bornholdt, Zachary A.; Murin, Charles D.; Sok, Devin; Fusco, Marnie L.; Pommert, Kathleen B. J.; Saphire, Erica Ollmann; Burton, Dennis R.] Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA.
[Turner, Hannah L.; Murin, Charles D.; Ward, Andrew B.] Scripps Res Inst, Dept Integrat Struct & Computat Biol, La Jolla, CA 92037 USA.
[Li, Wen; Krauland, Eric; Gerngross, Tillman U.; Wittrup, Karl D.; Walker, Laura M.] Adimab, Lebanon, NH 03766 USA.
[Souders, Colby A.; Cavacini, Lisa A.; Smith, Heidi L.; Klempner, Mark; Reimann, Keith A.] Univ Massachusetts, Sch Med, MassBiol, Boston, MA 02126 USA.
[Piper, Ashley E.; Goff, Arthur; Shamblin, Joshua D.; Wollen, Suzanne E.; Sprague, Thomas R.; Glass, Pamela J.] US Army, Med Res Inst Infect Dis, Frederick, MD 21702 USA.
[Burton, Dennis R.] MIT, Ragon Inst, Massachusetts Gen Hosp, Cambridge, MA 02142 USA.
[Burton, Dennis R.] Harvard Univ, Cambridge, MA 02142 USA.
RP Walker, LM (reprint author), Adimab, Lebanon, NH 03766 USA.
EM laura.walker@adimab.com
RI Ward, Andrew/F-9203-2014
OI Ward, Andrew/0000-0001-7153-3769
FU NIH/National Institute of Allergy and Infectious Diseases Center for
Excellence in Translational Research [U19AI109762]; NSF; U.S. NIH grants
[U19 AI109762, R01 AI067927]; Defense Advanced Research Projects Agency
[DARPA-BAA-13-03]; Center for HIV/AIDS Vaccine Immunology and Immunogen
Discovery [UM1AI100663]; [R01AI067927]
FX We thank T. Boland and M. Vasquez for assistance with antibody sequence
analysis, C. Williams and S. M. Eagol for assistance with figure
preparation, R. Pejchal for providing helpful comments on the
manuscript, and M. Haynes for assistance with flow cytometry. All of the
IgGs were sequenced by Adimab's Molecular Core and produced by the High
Throughput Expression group. BLI binding experiments were performed by
Adimab's protein analytics group. The ZMapp cocktail mAb 2G4 was
generously provided by Mapp Biopharmaceutical. The data presented in
this manuscript are tabulated in the main paper and in the supplementary
materials. GenBank accession numbers for the antibody variable-region
gene sequences reported in this study can be found in table S7. The
cryo-EM maps have been deposited to the Electron Microscopy Data Bank
(accession numbers EMD-6586, EMD-6587, EMD-6588, and EMD-6589). E.O.S.,
Z.A.B., M.L.F., K.B.J.P., A.B.W., H.L.T., and C.D.M. acknowledge support
from the NIH/National Institute of Allergy and Infectious Diseases
Center for Excellence in Translational Research Grant U19AI109762,
"Consortium for Immunotherapeutics Against Viral Hemorrhagic Fevers."
E.O.S. was also supported by R01AI067927. C.D.M. was supported by a
predoctoral fellowship from NSF. This study was supported in part by
U.S. NIH grants U19 AI109762 and R01 AI067927 awarded to E.O.S. Research
was funded in part by the Defense Advanced Research Projects Agency
(DARPA-BAA-13-03). D.R.B. and D.S. acknowledge support from Center for
HIV/AIDS Vaccine Immunology and Immunogen Discovery Grant UM1AI100663.
This is manuscript no. 29237 from The Scripps Research Institute.
Opinions, interpretations, conclusions, and recommendations are those of
the authors and are not necessarily endorsed by the U.S. Army.
NR 30
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U1 2
U2 13
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 0036-8075
EI 1095-9203
J9 SCIENCE
JI Science
PD MAR 4
PY 2016
VL 351
IS 6277
BP 1078
EP 1083
DI 10.1126/science.aad5788
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DF8HE
UT WOS:000371597500043
PM 26912366
ER
PT J
AU Bunker, RJ
Bunker, PL
AF Bunker, Robert J.
Bunker, Pamela Ligouri
TI The modern state in epochal transition: The significance of irregular
warfare, state deconstruction, and the rise of new warfighting entities
beyond neo-medievalism
SO SMALL WARS AND INSURGENCIES
LA English
DT Article
DE space-time manipulation; proxies; irregular warfare; state
deconstruction; Energy; mercenaries; new war; neo-medievalism; violent
non-state actors; Westphalian states; epochal war
AB This article is intended to serve as a 'think piece' which invites readers to view current perceived changes to the conduct of modern warfare in the broader historical light outlined by proponents of epochal change theory. Neo-medievalists have gone a step in this direction and posited that these changes represent the future of warfare and are evidence of a return, in a sense, to the primary tenets of political and social organization that existed in the period commonly referred to as the Middle Ages. The contention herein is that the answer gains more accuracy if one takes a much longer historical standpoint beginning with classical civilization and moving through the medieval period to our modern world. With regard to the present, this epochal warfare analysis projects that a shift from a Westphalian to post-Westphalian global system is underway. During this period of transition - as in the transition periods between epochs which have preceded it - the dominant state form undergoes a deinstitutionalization process, and war is less about traditional issues of state sovereignty, and instead increasingly over 'what the new form of social and political organization will be'.
C1 [Bunker, Robert J.] US Army, War Coll, Strateg Studies Inst, Carlisle, PA USA.
[Bunker, Pamela Ligouri] Small Wars Journal El Ctr, New York, NY USA.
RP Bunker, RJ (reprint author), US Army, War Coll, Strateg Studies Inst, Carlisle, PA USA.
EM robert.bunker@cgu.edu
NR 32
TC 0
Z9 0
U1 3
U2 6
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 0959-2318
EI 1743-9558
J9 SMALL WAR INSUR
JI Small War Insur.
PD MAR 3
PY 2016
VL 27
IS 2
SI SI
BP 325
EP 344
DI 10.1080/09592318.2015.1129168
PG 20
WC International Relations
SC International Relations
GA DH4LI
UT WOS:000372757100008
ER
PT J
AU Williamson, CHD
Sahl, JW
Smith, TJ
Xie, G
Foley, BT
Smith, LA
Fernandez, RA
Lindstrom, M
Korkeala, H
Keim, P
Foster, J
Hill, K
AF Williamson, Charles H. D.
Sahl, Jason W.
Smith, Theresa J.
Xie, Gary
Foley, Brian T.
Smith, Leonard A.
Fernandez, Rafael A.
Lindstrom, Miia
Korkeala, Hannu
Keim, Paul
Foster, Jeffrey
Hill, Karen
TI Comparative genomic analyses reveal broad diversity in
botulinum-toxin-producing Clostridia
SO BMC GENOMICS
LA English
DT Article
DE Clostridium botulinum; Botulinum neurotoxin; Whole genome sequence;
Comparative genomics
ID FRAGMENT LENGTH POLYMORPHISM; FIELD GEL-ELECTROPHORESIS; NEUROTOXIN
COMPLEX GENES; DNA-SEQUENCING DATA; GROUP-I; INFANT BOTULISM; E STRAINS;
PHYLOGENETIC ANALYSIS; HIGH-THROUGHPUT; FOOD
AB Background: Clostridium botulinum is a diverse group of bacteria characterized by the production of botulinum neurotoxin. Botulinum neurotoxins are classified into serotypes (BoNT/A-G), which are produced by six species/Groups of Clostridia, but the genetic background of the bacteria remains poorly understood. The purpose of this study was to use comparative genomics to provide insights into the genetic diversity and evolutionary history of bacteria that produce the potent botulinum neurotoxin.
Results: Comparative genomic analyses of over 170 Clostridia genomes, including our draft genome assemblies for 59 newly sequenced Clostridia strains from six continents and publicly available genomic data, provided in-depth insights into the diversity and distribution of BoNT-producing bacteria. These newly sequenced strains included Group I and II strains that express BoNT/A,/B,/E, or/F as well as bivalent strains. BoNT-producing Clostridia and closely related Clostridia species were delineated with a variety of methods including 16S rRNA gene, concatenated marker genes, core genome and concatenated multi-locus sequencing typing (MLST) gene phylogenies that related whole genome sequenced strains to publicly available strains and sequence types. These analyses illustrated the phylogenetic diversity in each Group and the diversity of genomic backgrounds that express the same toxin type or subtype. Comparisons of the botulinum neurotoxin genes did not identify novel toxin types or variants.
Conclusions: This study represents one of the most comprehensive analyses of whole genome sequence data for Group I and II BoNT-producing strains. Read data and draft genome assemblies generated for 59 isolates will be a resource to the research community. Core genome phylogenies proved to be a powerful tool for differentiating BoNT-producing strains and can provide a framework for the study of these bacteria. Comparative genomic analyses of Clostridia species illustrate the diversity of botulinum-neurotoxin-producing strains and the plasticity of the genomic backgrounds in which bont genes are found.
C1 [Williamson, Charles H. D.; Sahl, Jason W.; Keim, Paul; Foster, Jeffrey] Univ Arizona, Ctr Microbial Genet & Genom, Flagstaff, AZ 86011 USA.
[Smith, Theresa J.] US Army, Med Res Inst Infect Dis, Mol & Translat Sci Div, Ft Detrick, MD 21702 USA.
[Xie, Gary; Hill, Karen] Los Alamos Natl Lab, Biosci Div, POB 1663, Los Alamos, NM 87545 USA.
[Foley, Brian T.] Los Alamos Natl Lab, Div Theoret, Los Alamos, NM USA.
[Smith, Leonard A.] US Army, Med Res & Mat Command, Med Countermeasures Technol, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
[Fernandez, Rafael A.] Univ Nacl Cuyo, Fac Ciencias Med, Dept Patol, Area Microbiol,Ctr Univ, RA-5500 Mendoza, Argentina.
[Lindstrom, Miia; Korkeala, Hannu] Univ Helsinki, Dept Food Hyg & Environm Hlth, Helsinki, Finland.
[Foster, Jeffrey] Univ New Hampshire, Dept Mol Cellular & Biomed Sci, Durham, NH 03824 USA.
RP Keim, P; Foster, J (reprint author), Univ Arizona, Ctr Microbial Genet & Genom, Flagstaff, AZ 86011 USA.; Hill, K (reprint author), Los Alamos Natl Lab, Biosci Div, POB 1663, Los Alamos, NM 87545 USA.; Foster, J (reprint author), Univ New Hampshire, Dept Mol Cellular & Biomed Sci, Durham, NH 03824 USA.
EM Paul.Keim@nau.edu; Jeff.Foster@unh.edu; khill@lanl.gov
OI Foster, Jeffrey/0000-0001-8235-8564; xie, gary/0000-0002-9176-924X
FU U.S. Department of Homeland Security Science and Technology [HSHQDC 10 C
00139, DHS-2010-ST-108-000019]; Arizona's Technology Research Initiative
Fund; Arizona's Technology and Research Initiative Fund
FX The work was supported by the U.S. Department of Homeland Security
Science and Technology Directorate via awards HSHQDC 10 C 00139 and
DHS-2010-ST-108-000019. CHDW was supported by funding from Arizona's
Technology Research Initiative Fund. Some of the computational analyses
were run on Northern Arizona University's Monsoon computing cluster,
also funded by Arizona's Technology and Research Initiative Fund. The
authors would like to thank Dr. C. Shone of Public Health England,
Salisbury, UK for his kind gift of DNA from the Mauritius bont/A2
strain, and Dr. J. Rood of Monash University, Melbourne, Australia for
providing C. botulinum strains for analyses. Opinions, interpretations,
conclusions and recommendations are those of the authors and not
necessarily endorsed by the U.S. Army.
NR 104
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U1 8
U2 22
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2164
J9 BMC GENOMICS
JI BMC Genomics
PD MAR 3
PY 2016
VL 17
AR 180
DI 10.1186/s12864-016-2502-z
PG 20
WC Biotechnology & Applied Microbiology; Genetics & Heredity
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA DF8GI
UT WOS:000371595000006
PM 26939550
ER
PT J
AU Rice, BM
Byrd, EFC
AF Rice, Betsy M.
Byrd, Edward F. C.
TI Theoretical Study of Shocked Formic Acid: Born-Oppenheimer MD
Calculations of the Shock Hugoniot and Early-Stage Chemistry
SO JOURNAL OF PHYSICAL CHEMISTRY B
LA English
DT Article
ID MOLECULAR-DYNAMICS SIMULATIONS; HIGH-PRESSURE; INITIAL DECOMPOSITION;
ENERGETIC MATERIALS; BETA-HMX; RESPONSES; CURVE
AB Quantum and classical molecular dynamics simulations are used to explore whether chemical reactivity of shocked formic acid occurs at pressures greater than 15 GPa, a question arising from results of different shock compression experiments. The classical molecular dynamics simulations were performed using a quantum-based nonreactive pair additive interaction potential whereas the full resolution quantum mechanical molecular dynamics simulations allow chemical reactions. Although the shock Hugoniot curve calculated using nonreactive classical MD for fon-Mc acid is in reasonable agreement with one set of experimental results, shock Hugoniot points calculated using Born Oppenheimer MD at 30 GPa are in agreement with the set of experimental data that suggests chemical reactivity at these elevated temperatures and pressures. Examination of atomic positions throughout the Born Oppenheimer MD trajectories clearly indicates extensive and complex chemical reaction, chiefly involving hydrogen-atom-transfer and intermolecular complexation.
C1 [Rice, Betsy M.; Byrd, Edward F. C.] US Army, Res Lab ARL, Aberdeen, MD 21005 USA.
RP Rice, BM (reprint author), US Army, Res Lab ARL, Aberdeen, MD 21005 USA.
EM betsy.rice.civ@mail.mil
FU DoD High Performance Computing Modernization Program Software
Application Institute for Multi-Scale Reactive Modeling of Insensitive
Munitions
FX This work was partially supported by the DoD High Performance Computing
Modernization Program Software Application Institute for Multi-Scale
Reactive Modeling of Insensitive Munitions (2008-2014).
NR 38
TC 0
Z9 0
U1 5
U2 12
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1520-6106
J9 J PHYS CHEM B
JI J. Phys. Chem. B
PD MAR 3
PY 2016
VL 120
IS 8
BP 1711
EP 1719
DI 10.1021/acs.jpcb.5b08845
PG 9
WC Chemistry, Physical
SC Chemistry
GA DF7UI
UT WOS:000371562700034
PM 26654191
ER
PT J
AU Wang, XT
Byrd, M
Jacobs, K
AF Wang, Xiaoting
Byrd, Mark
Jacobs, Kurt
TI Minimal noise subsystems
SO PHYSICAL REVIEW LETTERS
LA English
DT Article
ID DECOHERENCE-FREE SUBSPACES; ERROR-CORRECTING CODES; QUANTUM COMPUTATION;
FIDELITY; STATES; MEMORY
AB A system subjected to noise contains a decoherence-free subspace or subsystem (DFS) only if the noise possesses an exact symmetry. Here we consider noise models in which a perturbation breaks a symmetry of the noise, so that if S is a DFS under a given noise process it is no longer so under the new perturbed noise process. We ask whether there is a subspace or subsystem that is more robust to the perturbed noise than S. To answer this question we develop a numerical method that allows us to search for subspaces or subsystems that are maximally robust to arbitrary noise processes. We apply this method to a number of examples, and find that a subsystem that is a DFS is often not the subsystem that experiences minimal noise when the symmetry of the noise is broken by a perturbation. We discuss which classes of noise have this property.
C1 [Wang, Xiaoting] Louisiana State Univ, Hearne Inst Theoret Phys, Baton Rouge, LA 70803 USA.
[Wang, Xiaoting] MIT, Elect Res Lab, Cambridge, MA 02139 USA.
[Wang, Xiaoting; Jacobs, Kurt] Univ Massachusetts, Dept Phys, Boston, MA 02125 USA.
[Byrd, Mark] So Illinois Univ, Dept Phys, Carbondale, IL 62901 USA.
[Byrd, Mark] So Illinois Univ, Dept Comp Sci, Carbondale, IL 62901 USA.
[Jacobs, Kurt] US Army Res Lab, Computat & Informat Sci Directorate, Adelphi, MD 20783 USA.
RP Wang, XT (reprint author), Louisiana State Univ, Hearne Inst Theoret Phys, Baton Rouge, LA 70803 USA.; Wang, XT (reprint author), MIT, Elect Res Lab, Cambridge, MA 02139 USA.; Wang, XT (reprint author), Univ Massachusetts, Dept Phys, Boston, MA 02125 USA.
EM xiaoting@lsu.edu
FU NSF [PHY-0902906, PHY-1005571, CCF-1350397]; Intelligence Advanced
Research Projects Activity (IARPA) via Department of Interior National
Business Center [D11PC20168]
FX K. J. and X. W. were partially supported by the NSF Projects No.
PHY-0902906, K. J. by No. PHY-1005571, and X. W. by No. CCF-1350397. All
the authors were partially supported by the Intelligence Advanced
Research Projects Activity (IARPA) via Department of Interior National
Business Center Contract No. D11PC20168.
NR 39
TC 0
Z9 0
U1 2
U2 4
PU AMER PHYSICAL SOC
PI COLLEGE PK
PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA
SN 0031-9007
EI 1079-7114
J9 PHYS REV LETT
JI Phys. Rev. Lett.
PD MAR 3
PY 2016
VL 116
IS 9
AR 090404
DI 10.1103/PhysRevLett.116.090404
PG 5
WC Physics, Multidisciplinary
SC Physics
GA DF5VC
UT WOS:000371419600002
PM 26991160
ER
PT J
AU Van Ombergen, A
Lawson, BD
Wuyts, FL
AF Van Ombergen, Angelique
Lawson, Ben D.
Wuyts, Floris L.
TI Motion sickness and sopite syndrome associated with parabolic flights: a
case report
SO INTERNATIONAL JOURNAL OF AUDIOLOGY
LA English
DT Article
DE Motion sickness; sopite syndrome; parabolic flight; vestibular system
ID INTRANASAL SCOPOLAMINE; SUSCEPTIBILITY; SCALE
AB Objective: The purpose of this paper was to provide an extensive description of a case of sopite syndrome, a manifestation of motion sickness scarcely described in the literature.Design: The following questionnaires were used to assess sopite syndrome symptoms pre, during and post parabolic flight; Misery Scale rate, Positive and Negative Affect Scale, the Motion Sickness Assessment Questionnaire and the Epworth Sleepiness Scale.Study sample: Case report of a 35-year old female compared to a control group (n=26).Results: We describe of sopite syndrome during parabolic flight. The subject reported drowsiness and she noted mood changes such as irritation and annoyance. Furthermore, she was not able to perform her assigned task. Her symptoms escalated into extreme fatigue and the inability to stay awake. Nauseogenic symptoms improved, but soporific symptoms persisted for several hours after the motion stimulus (i.e. parabolic flight).Conclusions: This case points towards the need for controlled studies to assess the prevalence of this syndrome among the general population and select groups. Future research should focus on developing tests for personnel screening and explore treatment options.
C1 [Van Ombergen, Angelique; Wuyts, Floris L.] Univ Antwerp, Res Ctr Equilibrium & Aerosp AUREA, Groenenborgerlaan 171, B-2020 Antwerp, Belgium.
[Lawson, Ben D.] US Army Aeromed Res Lab, Ft Rucker, AL 36362 USA.
RP Van Ombergen, A (reprint author), Univ Antwerp, Res Ctr Equilibrium & Aerosp AUREA, Groenenborgerlaan 171, B-2020 Antwerp, Belgium.
EM angelique.vanombergen@uantwerp.be
FU European Space Agency [ISLRA 2009-1062, LS60-3]; Belgian Science Policy
(Belspo, Prodex); Research Foundation Flanders (Belgium - FWO
Vlaanderen) [11U6414N, 11U6416N]
FX The authors would like to thank all participants for their cooperation
and the following coordinating persons: Vladimir Pletser (European Space
Agency), Alexandra Jaquement (Novespace, Bordeaux, France) & Frederic
Gai (Novespace, Bordeaux, France). This work was supported by the
European Space Agency (ISLRA 2009-1062 and LS60-3), Belgian Science
Policy (Belspo, Prodex) and the Research Foundation Flanders (Belgium -
FWO Vlaanderen, grant 11U6414N and 11U6416N). Angelique Van Ombergen is
a research fellow for FWO Vlaanderen.
NR 31
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Z9 2
U1 2
U2 4
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1499-2027
EI 1708-8186
J9 INT J AUDIOL
JI Int. J. Audiol.
PD MAR 3
PY 2016
VL 55
IS 3
BP 189
EP 194
DI 10.3109/14992027.2015.1111526
PG 6
WC Audiology & Speech-Language Pathology; Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Otorhinolaryngology
GA DE5BO
UT WOS:000370646000008
PM 26624575
ER
PT J
AU Ndungo, E
Herbert, AS
Raaben, M
Obernosterer, G
Biswas, R
Miller, EH
Wirchnianski, AS
Carette, JE
Brummelkamp, TR
Whelan, SP
Dye, JM
Chandran, K
AF Ndungo, Esther
Herbert, Andrew S.
Raaben, Matthijs
Obernosterer, Gregor
Biswas, Rohan
Miller, Emily Happy
Wirchnianski, Ariel S.
Carette, Jan E.
Brummelkamp, Thijn R.
Whelan, Sean P.
Dye, John M.
Chandran, Kartik
TI A Single Residue in Ebola Virus Receptor NPC1 Influences Cellular Host
Range in Reptiles
SO MSPHERE
LA English
DT Article
DE Ebola virus; NPC1; Niemann-Pick C1; endosomal receptor; filovirus;
intracellular receptor; reptiles; viral receptor; virus-host
interactions
ID NIEMANN-PICK C1; HEMORRHAGIC-FEVER ARENAVIRUSES; CROSS-SPECIES
TRANSMISSION; ENTRY REQUIRES; MARBURG VIRUS; GLYCOPROTEIN; INFECTION;
RECOGNITION; IDENTIFICATION; CORONAVIRUS
AB Filoviruses are the causative agents of an increasing number of disease outbreaks in human populations, including the current unprecedented Ebola virus disease (EVD) outbreak in western Africa. One obstacle to controlling these epidemics is our poor understanding of the host range of filoviruses and their natural reservoirs. Here, we investigated the role of the intracellular filovirus receptor, Niemann-Pick C1 (NPC1) as a molecular determinant of Ebola virus (EBOV) host range at the cellular level. Whereas human cells can be infected by EBOV, a cell line derived from a Russell's viper (Daboia russellii) (VH-2) is resistant to infection in an NPC1-dependent manner. We found that VH-2 cells are resistant to EBOV infection because the Russell's viper NPC1 ortholog bound poorly to the EBOV spike glycoprotein (GP). Analysis of panels of viper-human NPC1 chimeras and point mutants allowed us to identify a single amino acid residue in NPC1, at position 503, that bidirectionally influenced both its binding to EBOV GP and its viral receptor activity in cells. Significantly, this single residue change perturbed neither NPC1's endosomal localization nor its housekeeping role in cellular cholesterol trafficking. Together with other recent work, these findings identify sequences in NPC1 that are important for viral receptor activity by virtue of their direct interaction with EBOV GP and suggest that they may influence filovirus host range in nature. Broader surveys of NPC1 orthologs from vertebrates may delineate additional sequence polymorphisms in this gene that control susceptibility to filovirus infection.
IMPORTANCE Identifying cellular factors that determine susceptibility to infection can help us understand how Ebola virus is transmitted. We asked if the EBOV receptor Niemann-Pick C1 (NPC1) could explain why reptiles are resistant to EBOV infection. We demonstrate that cells derived from the Russell's viper are not susceptible to infection because EBOV cannot bind to viper NPC1. This resistance to infection can be mapped to a single amino acid residue in viper NPC1 that renders it unable to bind to EBOV GP. The newly solved structure of EBOV GP bound to NPC1 confirms our findings, revealing that this residue dips into the GP receptor-binding pocket and is therefore critical to the binding interface. Consequently, this otherwise well-conserved residue in vertebrate species influences the ability of reptilian NPC1 proteins to bind to EBOV GP, thereby affecting viral host range in reptilian cells.
C1 [Ndungo, Esther; Biswas, Rohan; Miller, Emily Happy; Chandran, Kartik] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10467 USA.
[Herbert, Andrew S.; Wirchnianski, Ariel S.; Dye, John M.] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
[Raaben, Matthijs; Whelan, Sean P.] Harvard Med Sch, Dept Microbiol & Immunobiol, Boston, MA USA.
[Raaben, Matthijs; Obernosterer, Gregor; Brummelkamp, Thijn R.] Netherlands Canc Inst, Amsterdam, Netherlands.
[Carette, Jan E.] Stanford Univ, Dept Microbiol & Immunol, Sch Med, Stanford, CA 94305 USA.
RP Chandran, K (reprint author), Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10467 USA.; Dye, JM (reprint author), US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
EM john.m.dye1.civ@mail.mil; kartik.chandran@einstein.yu.edu
OI Ndungo, Esther/0000-0002-9975-7032
FU HHS \ National Institutes of Health (NIH) [R01 AI088027, R01 AI101436];
DOD \ Defense Threat Reduction Agency (DTRA) [CB3948]
FX This work, including the efforts of Esther Ndungo, Rohan Biswas, Emily
Happy Miller, and Kartik Chandran, was funded by HHS vertical bar
National Institutes of Health (NIH) (R01 AI088027 and R01 AI101436).
This work, including the efforts of Andrew S. Herbert, Ariel S.
Wirchnianski, and John M. Dye, was funded by DOD vertical bar Defense
Threat Reduction Agency (DTRA) (CB3948).
NR 40
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Z9 1
U1 1
U2 1
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 2379-5042
J9 MSPHERE
JI mSphere
PD MAR-APR
PY 2016
VL 1
IS 2
AR UNSP e00007-16
DI 10.1128/mSphere.00007-16
PG 15
WC Microbiology
SC Microbiology
GA EI6DH
UT WOS:000392584700002
ER
PT J
AU Mayer, C
AF Mayer, Chris
TI SUSTAINING INNOVATION IN THE MIDST OF SUCCESS
SO JOURNAL OF LEADERSHIP STUDIES
LA English
DT Article
AB It seems strange to claim that it is dangerous for organizations to achieve the success they seek; however, there are numerous cases of successful organizations facing decline soon after achieving success. This often occurs because these organizations fall into the trap of focusing too much on execution once they achieve success, which causes them to neglect the innovative approach that enabled achieving success in the first place. To avoid this trap, leaders must ensure that their organizations have a clearly identified and transformative purpose that guides organizational member work and inspires them to improve. The leader must also ensure that there is a well-established and understood process for improvement that facilitates learning and innovation. Finally, the leader must model, and organizational policies must reflect, the proper balance between execution and innovation.
C1 [Mayer, Chris] US Mil Acad, Philosophy, West Point, NY 10996 USA.
[Mayer, Chris] US Mil Acad, Strategy Policy & Assessment, West Point, NY 10996 USA.
[Mayer, Chris] US Army, Arlington, VA USA.
RP Mayer, C (reprint author), US Mil Acad, Philosophy, West Point, NY 10996 USA.; Mayer, C (reprint author), US Mil Acad, Strategy Policy & Assessment, West Point, NY 10996 USA.
EM christopher.mayer@usma.edu
NR 7
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1935-2611
EI 1935-262X
J9 J LEADERSH STUD
JI J. Leadersh. Stud.
PD SPR
PY 2016
VL 10
IS 1
BP 73
EP 75
DI 10.1002/jls.21453
PG 3
WC Management
SC Business & Economics
GA EB2BM
UT WOS:000387161900022
ER
PT J
AU Fadel, TR
Farrell, DF
Friedersdorf, LE
Griep, MH
Hoover, MD
Meador, MA
Meyyappan, M
AF Fadel, Tarek R.
Farrell, Dorothy F.
Friedersdorf, Lisa E.
Griep, Mark H.
Hoover, Mark D.
Meador, Michael A.
Meyyappan, M.
TI Toward the Responsible Development and Commercialization of Sensor
Nanotechnologies
SO ACS SENSORS
LA English
DT Article
DE nanosensors; engineered nanomaterials; commercialization; data quality;
life cycle
ID CARBON NANOTUBES; NANOPORE SENSORS; DNA; NANOPARTICLES; GRAPHENE;
NANOMATERIALS; NANOSENSORS; TRANSISTOR; MOLECULES; SYSTEM
AB Nanotechnology-enabled sensors (or nano sensors) will play an important role in enabling the progression toward ubiquitous information systems as the Internet of Things (IoT) emerges. Nanosensors offer new, miniaturized solutions in physiochemical and biological sensing that enable increased sensitivity, specificity, and multiplexing capability, all with the compelling economic drivers of low cost and high-energy efficiency. In the United States, Federal agencies participating in the National Nano technology Initiative (NNI) "Nanotechnology for Sensors and Sensors for Nanotechnology: Improving and Protecting Health, Safety, and the Environment" Nanotechnology Signature Initiative (the Sensors NSI), address both the opportunity of using nanotechnology to advance sensor development and the challenges of developing sensors to keep pace with the increasingly widespread use of engineered nanomaterials. This perspective article will introduce and provide background on the NNI signature initiative on sensors. Recent efforts by the Sensors NSI aimed at promoting the successful development and commercialization of nanosensors will be reviewed and examples of sensor nanotechnologies will be highlighted. Future directions and critical challenges for sensor development will also be discussed.
C1 [Fadel, Tarek R.; Friedersdorf, Lisa E.; Meador, Michael A.] Natl Nanotechnol Coordinat Off, 4201 Wilson Blvd,Suite 405, Arlington, VA 22230 USA.
[Farrell, Dorothy F.] NCI, NIH, 31 Ctr Dr,10A52, Bethesda, MD 20892 USA.
[Griep, Mark H.] US Army, Res Lab, Aberdeen, MD 21005 USA.
[Hoover, Mark D.] NIOSH, 1095 Willowdale Rd, Morgantown, WV 26505 USA.
[Meyyappan, M.] NASA, Ames Res Ctr, Ctr Nanotechnol, Moffett Field, CA 94035 USA.
RP Fadel, TR (reprint author), Natl Nanotechnol Coordinat Off, 4201 Wilson Blvd,Suite 405, Arlington, VA 22230 USA.
EM TFadel@nnco.nano.gov
NR 76
TC 1
Z9 1
U1 6
U2 6
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 2379-3694
J9 ACS SENSORS
JI ACS Sens.
PD MAR
PY 2016
VL 1
IS 3
BP 207
EP 216
DI 10.1021/acssensors.5b00279
PG 10
WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology
SC Chemistry; Science & Technology - Other Topics
GA DY9OT
UT WOS:000385464400002
PM 28261665
ER
PT J
AU Ahrari, EM
AF Ahrari, Ehsan M.
TI Is the American Century Over?
SO MEDITERRANEAN QUARTERLY-A JOURNAL OF GLOBAL ISSUES
LA English
DT Book Review
C1 [Ahrari, Ehsan M.] US Army, War Coll, Strateg Studies Inst, Carlisle, PA 17013 USA.
RP Ahrari, EM (reprint author), US Army, War Coll, Strateg Studies Inst, Carlisle, PA 17013 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU DUKE UNIV PRESS
PI DURHAM
PA 905 W MAIN ST, STE 18-B, DURHAM, NC 27701 USA
SN 1047-4552
EI 1527-1935
J9 MEDITERR Q
JI Mediterr. Q.
PD MAR
PY 2016
VL 27
IS 1
BP 122
EP 125
DI 10.1215/10474552-3488093
PG 4
WC International Relations
SC International Relations
GA DZ1PT
UT WOS:000385611000008
ER
PT J
AU Merefield, DC
Beckham, J
AF Merefield, David C.
Beckham, Jerry
TI Cardiac arrest in Antarctica-a successful outcome
SO JOURNAL OF TRAVEL MEDICINE
LA English
DT Letter
C1 [Merefield, David C.] Coral Coast Anaesthesia, Bundaberg, Qld, Australia.
Tripler Army Med Ctr, Dept Emergency Med, Honolulu, HI 96859 USA.
Univ Hawaii Honolulu, John A Burns Sch Med, Dept Surg, Honolulu, HI USA.
RP Merefield, DC (reprint author), Coral Coast Anaesthesia, Bundaberg, Qld, Australia.
NR 3
TC 0
Z9 0
U1 0
U2 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1195-1982
EI 1708-8305
J9 J TRAVEL MED
JI J. Travel Med.
PD MAR
PY 2016
VL 23
IS 3
AR taw015
DI 10.1093/jtm/taw015
PG 1
WC Medicine, General & Internal
SC General & Internal Medicine
GA DV9IV
UT WOS:000383255000016
ER
PT J
AU Summers, SM
Chin, EJ
Long, BJ
Grisell, RD
Knight, JG
Grathwohl, KW
Ritter, JL
Morgan, JD
Salinas, J
Blackbourne, LH
AF Summers, Shane M.
Chin, Eric J.
Long, Brit J.
Grisell, Ronald D.
Knight, John G.
Grathwohl, Kurt W.
Ritter, John L.
Morgan, Jeffrey D.
Salinas, Jose
Blackbourne, Lorne H.
TI Computerized Diagnostic Assistant for the Automatic Detection of
Pneumothorax on Ultrasound: A Pilot Study
SO WESTERN JOURNAL OF EMERGENCY MEDICINE
LA English
DT Article
DE Ultrasound; Pneumothorax; Automated; Diagnosis; Bedside
ID BREAST ULTRASOUND; AIDED DIAGNOSIS; CLASSIFICATION; CANCER; IMAGES;
SYSTEM; ULTRASONOGRAPHY; METAANALYSIS; MAMMOGRAPHY; PERFORMANCE
AB Introduction: Bedside thoracic ultrasound (US) can rapidly diagnose pneumothorax (PTX) with improved accuracy over the physical examination and without the need for chest radiography (CXR); however, US is highly operator dependent. A computerized diagnostic assistant was developed by the United States Army Institute of Surgical Research to detect PTX on standard thoracic US images. This computer algorithm is designed to automatically detect sonographic signs of PTX by systematically analyzing B-mode US video clips for pleural sliding and M-mode still images for the seashore sign. This was a pilot study to estimate the diagnostic accuracy of the PTX detection computer algorithm when compared to an expert panel of US trained physicians.
Methods: This was a retrospective study using archived thoracic US obtained on adult patients presenting to the emergency department (ED) between 5/23/2011 and 8/6/2014. Emergency medicine residents, fellows, attending physicians, physician assistants, and medical students performed the US examinations and stored the images in the picture archive and communications system (PACS). The PACS was queried for all ED bedside US examinations with reported positive PTX during the study period along with a random sample of negatives. The computer algorithm then interpreted the images, and we compared the results to an independent, blinded expert panel of three physicians, each with experience reviewing over 10,000 US examinations.
Results: Query of the PACS system revealed 146 bedside thoracic US examinations for analysis. Thirteen examinations were indeterminate and were excluded. There were 79 true negatives, 33 true positives, 9 false negatives, and 12 false positives. The test characteristics of the algorithm when compared to the expert panel were sensitivity 79% (95 % CI [63-89]) and specificity 87% (95% CI [77-93]). For the 20 images scored as highest quality by the expert panel, the algorithm demonstrated 100% sensitivity (95% CI [56-100]) and 92% specificity (95% CI [62-100]).
Conclusion: This novel computer algorithm has potential to aid clinicians with the identification of the sonographic signs of PTX in the absence of expert physician sonographers. Further refinement and training of the algorithm is still needed, along with prospective validation, before it can be utilized in clinical practice.
C1 [Summers, Shane M.; Chin, Eric J.; Long, Brit J.; Knight, John G.; Morgan, Jeffrey D.] Brooke Army Med Ctr, Dept Emergency Med, 3851 Roger Brooke Dr, San Antonio, TX 78234 USA.
[Ritter, John L.] Brooke Army Med Ctr, Dept Radiol, San Antonio, TX USA.
[Grathwohl, Kurt W.] Brooke Army Med Ctr, Dept Pulm Crit Care, San Antonio, TX USA.
[Grisell, Ronald D.; Salinas, Jose] US Army, Inst Surg Res, San Antonio, TX USA.
[Blackbourne, Lorne H.] US Army, Med Dept Ctr & Sch, Ft Sam Houston, TX USA.
RP Long, BJ (reprint author), Brooke Army Med Ctr, Dept Emergency Med, 3851 Roger Brooke Dr, San Antonio, TX 78234 USA.
EM brit.long@yahoo.com
NR 24
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U1 0
U2 1
PU WESTJEM
PI ORANGE
PA C/O SHAHRAM LOTFIPOUR, MD, MPH, 333 CITY BLVD W STE 640, RT 128-01,
ORANGE, CA 92868 USA
SN 1936-900X
EI 1936-9018
J9 WEST J EMERG MED
JI West. J. Emerg. Med.
PD MAR
PY 2016
VL 17
IS 4
BP 209
EP 215
DI 10.5811/westjem.2016.1.28087
PG 7
WC Emergency Medicine
SC Emergency Medicine
GA DV3QE
UT WOS:000382837100021
PM 26973754
ER
PT J
AU Crocker, FH
Blakeney, GA
Jung, CM
AF Crocker, Fiona H.
Blakeney, G. Alon
Jung, Carina M.
TI Complete Degradation of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) by
a Co-Culture of Gordonia sp. KTR9 and Methylobacterium sp. JS178
SO REMEDIATION-THE JOURNAL OF ENVIRONMENTAL CLEANUP COSTS TECHNOLOGIES &
TECHNIQUES
LA English
DT Article
ID BACTERIAL CONSORTIUM; EXPLOSIVE HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE;
BIODEGRADATION; STRAIN; MINERALIZATION; METABOLITES; CATABOLISM;
TOXICITY; PATHWAYS; ATRAZINE
AB The presence of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) in soil and groundwater is a major contamination issue at many military facilities around the world. Gordonia sp. KTR9 metabolizes RDX as a nitrogen source for growth producing 4-nitro-2,4-diazabutanal (NDAB) as a dead-end product. Methylobacterium sp. strain JS178 degrades NDAB as a sole source of nitrogen for growth. A mixed culture of strains KTR9 and JS178 was able to completely degrade RDX. There was no difference in rate of RDX degradation by KTR9 alone or in co-culture with JS178. The first-order degradation coefficients of RDX and NDAB in the co-culture were 0.08 hr(-1) and 0.002 hr(-1), respectively. In the co-culture that initially contained RDX plus NDAB, strain JS178 degraded the NDAB that was produced by KTR9 as shown by a decrease in the molar yield of NDAB (from RDX) from 1.0 to -0.11. Co-cultures of strains KTR9 and JS178 could be used to promote complete degradation of RDX in soils or groundwater. (C) 2016 Wiley Periodicals, Inc.
C1 [Crocker, Fiona H.] Engn Res & Dev Ctr Vicksburg, Environm Lab, Vicksburg, MS 39180 USA.
[Blakeney, G. Alon] Bennett Aerosp Inc, Vicksburg, MS USA.
[Jung, Carina M.] Engn Res & Dev Ctr Vicksburg, Vicksburg, MS USA.
RP Crocker, FH (reprint author), Engn Res & Dev Ctr Vicksburg, Environm Lab, Vicksburg, MS 39180 USA.
NR 23
TC 0
Z9 0
U1 3
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1051-5658
EI 1520-6831
J9 REMEDIATION
JI Remediation
PD SPR
PY 2016
VL 26
IS 2
BP 51
EP 58
DI 10.1002/rem.21457
PG 8
WC Engineering, Environmental
SC Engineering
GA DQ8XZ
UT WOS:000379496300004
ER
PT J
AU Lazarus, N
Meyer, CD
AF Lazarus, N.
Meyer, C. D.
TI Stretchable inductor with liquid magnetic core
SO MATERIALS RESEARCH EXPRESS
LA English
DT Article
DE ferrofluid; stretchable electronics; inductors; liquid metal
ID FERRO-NANOFLUID; ELECTRONICS; TRANSFORMERS; FLUID
AB Adding magnetic materials is a well-established method for improving performance of inductors. However, traditional magnetic cores are rigid and poorly suited for the emerging field of stretchable electronics, where highly deformable inductors are used to wirelessly couple power and data signals. In this work, stretchable inductors are demonstrated based on the use of ferrofluids, magnetic liquids based on distributed magnetic particles, to create a compliant magnetic core. Using a silicone molding technique to create multi-layer fluidic channels, a liquid metal solenoid is fabricated around a ferrofluid channel. An analytical model is developed for the effects of mechanical strain, followed by experimental verification using two different ferrofluids with different permeabilities. Adding ferrofluid was found to increase the unstrained inductance by up to 280% relative to a similar inductor with a non-magnetic silicone core, while retaining the ability to survive uniaxial strains up to 100%.
C1 [Lazarus, N.; Meyer, C. D.] US Army, Sensors & Electron Devices Directorate, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
RP Lazarus, N (reprint author), US Army, Sensors & Electron Devices Directorate, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM nathan.lazarus2.civ@mail.mil
NR 35
TC 0
Z9 0
U1 4
U2 5
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 2053-1591
J9 MATER RES EXPRESS
JI Mater. Res. Express
PD MAR
PY 2016
VL 3
IS 3
AR 036103
DI 10.1088/2053-1591/3/3/036103
PG 10
WC Materials Science, Multidisciplinary
SC Materials Science
GA DO5GH
UT WOS:000377811100032
ER
PT J
AU Finkel, P
Moyet, RP
Wun-Fogle, M
Restorff, J
Kosior, J
Staruch, M
Stace, J
Amin, A
AF Finkel, Peter
Moyet, Richard Perez
Wun-Fogle, Marilyn
Restorff, James
Kosior, Jesse
Staruch, Margo
Stace, Joseph
Amin, Ahmed
TI Non-Resonant Magnetoelectric Energy Harvesting Utilizing Phase
Transformation in Relaxor Ferroelectric Single Crystals
SO ACTUATORS
LA English
DT Article
DE energy harvesting; magnetoelectric; inter-ferroelectric phase
transformation; broadband; low frequency; multi-domain
ID CONVERTER
AB Recent advances in phase transition transduction enabled the design of a non-resonant broadband mechanical energy harvester that is capable of delivering an energy density per cycle up to two orders of magnitude larger than resonant cantilever piezoelectric type generators. This was achieved in a [011] oriented and poled domain engineered relaxor ferroelectric single crystal, mechanically biased to a state just below the ferroelectric rhombohedral (F-R)-ferroelectric orthorhombic (F-O) phase transformation. Therefore, a small variation in an input parameter, e.g., electrical, mechanical, or thermal will generate a large output due to the significant polarization change associated with the transition. This idea was extended in the present work to design a non-resonant, multi-domain magnetoelectric composite hybrid harvester comprised of highly magnetostrictive alloy, [Fe81.4Ga18.6 (Galfenol) or TbxDy1-xFe2 (Terfenol-D)], and lead indium niobate-lead magnesium niobate-lead titanate (PIN-PMN-PT) domain engineered relaxor ferroelectric single crystal. A small magnetic field applied to the coupled device causes the magnetostrictive element to expand, and the resulting stress forces the phase change in the relaxor ferroelectric single crystal. We have demonstrated high energy conversion in this magnetoelectric device by triggering the F-R-F-O transition in the single crystal by a small ac magnetic field in a broad frequency range that is important for multi-domain hybrid energy harvesting devices.
C1 [Finkel, Peter; Staruch, Margo] US Navy, Res Lab, Mat Sci & Technol Div, Washington, DC 20375 USA.
[Moyet, Richard Perez] Univ Connecticut, Dept Mat Sci & Engn, Storrs, CT 06269 USA.
[Moyet, Richard Perez] Univ Connecticut, Inst Mat Sci, Storrs, CT 06269 USA.
[Wun-Fogle, Marilyn; Restorff, James] US Army, Ctr Surface Warfare, Survivabil Struct & Mat Dept, Carderock Div, Bethesda, MD 20817 USA.
[Kosior, Jesse] Rowan Univ, Dept Phys & Astron, Glassboro, NJ 08028 USA.
[Stace, Joseph; Amin, Ahmed] US Navy, Undersea Warfare Ctr, Sensors & Sonar Syst Dept, Newport, RI 02841 USA.
RP Finkel, P (reprint author), US Navy, Res Lab, Mat Sci & Technol Div, Washington, DC 20375 USA.
EM peter.finkel@nrl.navy.mil; richard.perez_moyet@uconn.edu;
marilyn.wun-fogle@navy.mil; james.restorff@navy.mil;
kosior20@students.rowan.edu; margo.staruch@nrl.navy.mil;
joseph.stace@navy.mil; ahmed.amin@navy.mil
RI Staruch, Margo/M-9260-2015
OI Staruch, Margo/0000-0003-3088-2553
NR 17
TC 0
Z9 0
U1 11
U2 13
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 2076-0825
J9 ACTUATORS
JI Actuators
PD MAR
PY 2016
VL 5
IS 1
AR 2
DI 10.3390/act5010002
PG 8
WC Instruments & Instrumentation
SC Instruments & Instrumentation
GA DO2KX
UT WOS:000377609900002
ER
PT J
AU Lotufo, GR
Belden, JB
Fisher, JC
Chen, SF
Mowery, RA
Chambliss, CK
Rosen, G
AF Lotufo, Guilherme R.
Belden, Jason B.
Fisher, Jonathon C.
Chen, Shou-Feng
Mowery, Richard A.
Chambliss, C. Kevin
Rosen, Gunther
TI Accumulation and depuration of trinitrotoluene and related extractable
and nonextractable (bound) residues in marine fish and mussels
SO ENVIRONMENTAL POLLUTION
LA English
DT Article
DE Trinitrotoluene; Bound residue; Nonextractable; Fish; Mussel
ID CHROMATOGRAPHY-MASS-SPECTROMETRY; CATFISH ICTALURUS-PUNCTATUS; EARTHWORM
EISENIA-ANDREI; COVALENT BINDING; MUNITIONS CONSTITUENTS; EXPLOSIVE
COMPOUNDS; AQUATIC ORGANISMS; PROTEIN ADDUCTS; 2,4,6-TRINITROTOLUENE;
TNT
AB To determine if trinitrotoluene (TNT) forms nonextractable residues in mussels (Mytilus galloprovincialis) and fish (Cyprinodon variegatus) and to measure the relative degree of accumulation as compared to extractable TNT and its major metabolites, organisms were exposed to water fortified with C-14-TNT. After 24 h, nonextractable residues made up 75% (mussel) and 83% (fish) while TNT accounted for 2% of total radioactivity. Depuration half-lives for extractable TNT, aminodinitrotoluenes (ADNTs) and diaminonitrotoluenes (DANTs) were fast initially (<0.5 h), but slower for nonextractable residues. Nonextractable residues from organisms were identified as ADNTs and DANTs using 0.1 M HCL for solubilization followed by liquid chromatography-tandem mass spectrometry. Recovered metabolites only accounted for a small fraction of the bound residue quantified using a radiotracer likely because of low extraction or hydrolysis efficiency or alternative pathways of incorporation of radiolabel into tissue. Published by Elsevier Ltd.
C1 [Lotufo, Guilherme R.] US Army Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
[Belden, Jason B.] Oklahoma State Univ, Dept Integrat Biol, Stillwater, OK 74078 USA.
[Fisher, Jonathon C.] Northwestern State Univ, Dept Nat Sci, Tahlequah, OK 74464 USA.
[Chen, Shou-Feng; Mowery, Richard A.; Chambliss, C. Kevin] Baylor Univ, Dept Chem, POB 97348, Waco, TX 76798 USA.
[Rosen, Gunther] Space & Naval Warfare SPAWAR Syst Ctr Pacific, 53475 Strothe Rd, San Diego, CA 92152 USA.
RP Lotufo, GR (reprint author), US Army Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM guilherme.lotufo@usace.army.mil
NR 40
TC 0
Z9 0
U1 4
U2 6
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0269-7491
EI 1873-6424
J9 ENVIRON POLLUT
JI Environ. Pollut.
PD MAR
PY 2016
VL 210
BP 129
EP 136
DI 10.1016/j.envpol.2015.11.049
PG 8
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA DM9RO
UT WOS:000376703600016
PM 26708767
ER
PT J
AU van Vuren, PJ
Wiley, M
Palacios, G
Storm, N
McCulloch, S
Markotter, W
Birkhead, M
Kemp, A
Paweska, JT
AF van Vuren, Petrus Jansen
Wiley, Michael
Palacios, Gustavo
Storm, Nadia
McCulloch, Stewart
Markotter, Wanda
Birkhead, Monica
Kemp, Alan
Paweska, Janusz T.
TI Isolation of a Novel Fusogenic Orthoreovirus from Eucampsipoda africana
Bat Flies in South Africa
SO VIRUSES-BASEL
LA English
DT Article
DE bat flies; Reoviridae; Eucampsipoda africana; fusogenic orthoreovirus;
Rousettus aegyptiacus; Nycteribiidae
ID FRUIT BATS; VIRUS; REOVIRUS; RHABDOVIRUS; NYCTERIBIIDAE; INFECTIONS;
RESERVOIRS; STREBLIDAE; SEQUENCES; DISEASE
AB We report on the isolation of a novel fusogenic orthoreovirus from bat flies (Eucampsipoda africana) associated with Egyptian fruit bats (Rousettus aegyptiacus) collected in South Africa. Complete sequences of the ten dsRNA genome segments of the virus, tentatively named Mahlapitsi virus (MAHLV), were determined. Phylogenetic analysis places this virus into a distinct clade with Baboon orthoreovirus, Bush viper reovirus and the bat-associated Broome virus. All genome segments of MAHLV contain a 5' terminal sequence (5'-GGUCA) that is unique to all currently described viruses of the genus. The smallest genome segment is bicistronic encoding for a 14 kDa protein similar to p14 membrane fusion protein of Bush viper reovirus and an 18 kDa protein similar to p16 non-structural protein of Baboon orthoreovirus. This is the first report on isolation of an orthoreovirus from an arthropod host associated with bats, and phylogenetic and sequence data suggests that MAHLV constitutes a new species within the Orthoreovirus genus.
C1 [van Vuren, Petrus Jansen; Storm, Nadia; Birkhead, Monica; Kemp, Alan; Paweska, Janusz T.] Natl Inst Communicable Dis, Ctr Emerging & Zoonot Dis, Natl Hlth Lab Serv, ZA-2131 Johannesburg, South Africa.
[van Vuren, Petrus Jansen; Storm, Nadia; McCulloch, Stewart; Markotter, Wanda; Paweska, Janusz T.] Univ Pretoria, Fac Nat & Agr Sci, Dept Microbiol & Plant Pathol, ZA-0028 Pretoria, South Africa.
[Wiley, Michael; Palacios, Gustavo] US Army, Med Res Inst Infect Dis, Ctr Genom Sci, Ft Detrick, MD 21702 USA.
[Paweska, Janusz T.] Univ Witwatersrand, Fac Hlth Sci, ZA-2193 Johannesburg, South Africa.
RP Paweska, JT (reprint author), Natl Inst Communicable Dis, Ctr Emerging & Zoonot Dis, Natl Hlth Lab Serv, ZA-2131 Johannesburg, South Africa.; Paweska, JT (reprint author), Univ Pretoria, Fac Nat & Agr Sci, Dept Microbiol & Plant Pathol, ZA-0028 Pretoria, South Africa.; Paweska, JT (reprint author), Univ Witwatersrand, Fac Hlth Sci, ZA-2193 Johannesburg, South Africa.
EM petrusv@nicd.ac.za; michael.r.wiley19.ctr@mail.mil;
gustavo.f.palacios.ctr@mail.mil; nadias@nicd.ac.za;
Stewart.Mcculloch@up.ac.za; Wanda.Markotter@up.ac.za;
monicab@nicd.ac.za; alank@nicd.ac.za; januszp@nicd.ac.za
OI Markotter, Wanda/0000-0002-7550-0080; Palacios,
Gustavo/0000-0001-5062-1938
FU CDC Global Disease Detection program [GDD 5U19 GH000571-05/96667]; South
African National Research Foundation [91496, 92524]; Poliomyelitis
Research Foundation, PRF [12/14]; South African National Research
Foundation, Incentive Funding for Rated Researchers [85544]; NRF
FX The project is jointly funded by the following grants awarded to: Janusz
T. Paweska (CDC Global Disease Detection program, GDD 5U19
GH000571-05/96667), Wanda Markotter (South African National Research
Foundation, Grant UID 91496 and 92524; Poliomyelitis Research
Foundation, PRF Grant number 12/14) and Petrus Jansen van Vuren (South
African National Research Foundation, Incentive Funding for Rated
Researchers, Grant UID 85544).; The grant holders acknowledge that
opinions, findings and conclusions or recommendations expressed in any
publication generated by GDD and NRF-supported research are those of the
authors and that the GDD and NRF accept no liability whatsoever in this
regard.
NR 46
TC 0
Z9 0
U1 0
U2 4
PU MDPI AG
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1999-4915
J9 VIRUSES-BASEL
JI Viruses-Basel
PD MAR
PY 2016
VL 8
IS 3
AR 65
DI 10.3390/v8030065
PG 25
WC Virology
SC Virology
GA DI6HH
UT WOS:000373599300009
ER
PT J
AU Sherlock, T
AF Sherlock, Thomas
TI Russian politics and the Soviet past: Reassessing Stalin and Stalinism
under Vladimir Putin
SO COMMUNIST AND POST-COMMUNIST STUDIES
LA English
DT Article
DE Vladimir Putin; Russian nationalism; Russkii Mir; Eurasianism; Crimea;
Donbas; Political identity; Soviet history; Memorialization; History
textbooks; Stalinism; Stalin; Historical narratives; Grand narrative
AB Evidence drawn from the intersection of historical memory and politics in Russia underline not only on-going framing battles over the Soviet past. The evidence suggests that the Kremlin is unwilling to develop and impose on society historical narratives which promote chauvinism, hypernationalism, and re-Stalinization. Although such an agenda has some support among incumbent elites and in society, it remains subordinate in terms of political influence as of early 2016. Instead, the regime is now extending support to groups in society and the political establishment which favor a critical assessment of the Soviet era, including Stalinism. This emerging criticism of the Soviet past serves a number of important goals of the leadership, including re-engagement with the West.
To this end, the Kremlin recently approved new history textbooks critical of the Soviet past as well as a significant program that memorializes the victims of Soviet repressions. Yet the regime is unlikely to usher in thorough de-Stalinization which would threaten its power. Instead, the Kremlin is attempting to assemble a grand narrative that approves, as well as criticizes - in different measures - each of the regimes that existed in the 20th century (tsarist, communist, and post-communist). This incipient narrative constitutes a form of bricolage, which involves the retrieval and reassembly of diverse, often conflicting, elements to solve a problem. Here the problem is the long-standing, divisive issue of how to evaluate the history of 20th century Russia and its different regimes. The Kremlin now seeks to knit together the diverse identities of these regimes through the unifying historical thread of the Russian state. This act of bricolage also seeks to reconcile the contradictions within each regime: elements of the new narrative can be expected to condemn the inhumanity of Stalin and Stalinism while other facets will extol industrialization and the Great Patriotic War as the achievements of Russian-led Soviet society. From this perspective, neither re-Stalinization nor de-Stalinization is likely to occur in Putin's Russia. Nevertheless, if recent initiatives remain in place, critical assessments of Soviet foreign and domestic policies will become increasingly commonplace. (C) 2016 Published by Elsevier Ltd on behalf of The Regents of the University of California.
C1 [Sherlock, Thomas] US Mil Acad, Dept Social Sci, West Point, NY USA.
RP Sherlock, T (reprint author), US Mil Acad, Dept Social Sci, West Point, NY USA.
NR 62
TC 0
Z9 0
U1 4
U2 5
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0967-067X
EI 1873-6920
J9 COMMUNIS POST-COMMUN
JI Communist Post-Communist Stud.
PD MAR
PY 2016
VL 49
IS 1
SI SI
BP 45
EP 59
DI 10.1016/j.postcomstud.2016.01.001
PG 15
WC International Relations; Political Science
SC International Relations; Government & Law
GA DK0JJ
UT WOS:000374598800005
ER
PT J
AU Ibrahim, SH
Hirsova, P
Tomita, K
Bronk, SF
Werneburg, NW
Harrison, SA
Goodfellow, VS
Malhi, H
Gores, GJ
AF Ibrahim, Samar H.
Hirsova, Petra
Tomita, Kyoko
Bronk, Steven F.
Werneburg, Nathan W.
Harrison, Stephen A.
Goodfellow, Val S.
Malhi, Harmeet
Gores, Gregory J.
TI Mixed Lineage Kinase 3 Mediates Release of C-X-C Motif Ligand 10-Bearing
Chemotactic Extracellular Vesicles From Lipotoxic Hepatocytes
SO HEPATOLOGY
LA English
DT Article
ID FATTY LIVER-DISEASE; P38 MAP KINASE; NONALCOHOLIC STEATOHEPATITIS;
PATHOGENESIS; ACTIVATION; APOPTOSIS; PROTEIN; CXCL10; CELLS;
LYSOPHOSPHATIDYLCHOLINE
AB Mixed lineage kinase 3 (MLK3) deficiency reducesmacrophage-associated inflammation in a murine model of nonalcoholic steatohepatitis (NASH). However, the mechanistic links between MLK3 activation in hepatocytes and macrophage-driven inflammation in NASH are uncharted. Herein, we report that MLK3 mediates the release of (C-X-C motif) ligand 10 (CXCL10)-laden extracellular vesicles (EVs) from lipotoxic hepatocytes, which induce macrophage chemotaxis. Primary mouse hepatocytes (PMHs) and Huh7 cells were treated with palmitate or lysophosphatidylcholine (LPC). Released EVs were isolated by differential ultracentrifugation. LPC treatment of PMH or Huh7 cells induced release of EVs, which was prevented by either genetic or pharmacological inhibition of MLK3. Mass spectrometry identified the potent chemokine, CXCL10, in the EVs, which was markedly enriched in EVs isolated from LPC-treated hepatocytes versus untreated cells. Green fluorescent protein (GFP)-tagged CXCL10 was present in vesicular structures and colocalized with the red fluorescent protein (RFP)-tagged EV marker, CD63, after LPC treatment of cotransfected Huh-7 cells. Either genetic deletion or pharmacological inhibition of MLK3 prevented CXCL10 enrichment in EVs. Treatment of mouse bonemarrow-derived macrophages with lipotoxic hepatocyte-derived EVs induced macrophage chemotaxis, an effect blocked by incubation with CXCL10-neutralizing antisera. MLK3-deficientmice fed a NASH-inducing diet had reduced concentrations of total plasma EVs and CXCL10 containing EVs compared to wild-type mice. Conclusions: During hepatocyte lipotoxicity, activated MLK3 induces the release ofCXCL10-bearing vesicles from hepatocytes, which are chemotactic for macrophages.
C1 [Ibrahim, Samar H.] Mayo Clin, Div Pediat Gastroenterol, Rochester, MN 55905 USA.
[Hirsova, Petra; Tomita, Kyoko; Bronk, Steven F.; Werneburg, Nathan W.; Malhi, Harmeet; Gores, Gregory J.] Mayo Clin, Div Gastroenterol & Hepatol, Rochester, MN 55905 USA.
[Harrison, Stephen A.] Brooke Army Med Ctr, Houston, TX USA.
[Goodfellow, Val S.] Califia Bio Inc, San Diego, CA USA.
RP Gores, GJ (reprint author), Mayo Clin, Med & Physiol, 200 First St SW, Rochester, MN 55905 USA.
EM gores.gregory@mayo.edu
FU Center for Clinical and Translational Science (CCaTS), KL2 program
[KL2TR000136-09]; Pilot and Feasibility Award; Mayo Clinic Center for
Cell Signaling in Gastroenterology [P30DK084567]; National Institutes of
Health (NIH) [DK97178]; NIH [DK41876]; Mayo Clinic (Rochester, MN)
FX This work was supported by the Center for Clinical and Translational
Science (CCaTS), KL2 program KL2TR000136-09 (to S.H.I.), a Pilot and
Feasibility Award (to S.H.I.), and the optical microscopy core of the
Mayo Clinic Center for Cell Signaling in Gastroenterology (P30DK084567),
National Institutes of Health (NIH) DK97178 (to H.M.), NIH grant DK41876
(to G.J.G.), and the Mayo Clinic (Rochester, MN).
NR 40
TC 7
Z9 7
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0270-9139
EI 1527-3350
J9 HEPATOLOGY
JI Hepatology
PD MAR
PY 2016
VL 63
IS 3
BP 731
EP 744
DI 10.1002/hep.28252
PG 14
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA DJ8WF
UT WOS:000374493200011
PM 26406121
ER
PT J
AU Scribner, DR
AF Scribner, David R.
TI Predictors of Shoot-Don't Shoot Decision-Making Performance: An
Examination of Cognitive and Emotional Factors
SO JOURNAL OF COGNITIVE ENGINEERING AND DECISION MAKING
LA English
DT Article
DE marksmanship; soldier performance; decision making; workload;
fratricide; individual factors; emotional factors; working memory
capacity
ID WORKING-MEMORY CAPACITY; INDIVIDUAL-DIFFERENCES; EXECUTIVE ATTENTION;
FLUID INTELLIGENCE; SELF-REGULATION; ANXIETY; STRESS
AB Soldiers are required to perform basic combat tasks, such as move, shoot, and communicate, and to make decisions under many environmental stressors, including continuous operations and information-processing tasks driven by C4ISR (Command, Control, Communications, Computers, Intelligence, Surveillance, and Reconnaissance) and other types of information systems. Knowledge requires information processing, and increased processing is usually the root cause of increased error. Friend-or-foe decision-making research has primarily focused on the types of equipment being used and task difficulty levels to examine shoot-don't shoot errors; however, newer theoretical approaches may enhance cognitive performance research and models focused on decision-making performance. Higher explanatory power and better prediction models may be created using multitheoretical individual factors derived from transactional-stress and information-processing theories. The purpose of this study was to examine multitheoretical individual factor effects of emotional and cognitive predictor variables under dual-task simulated shoot-don't shoot target scenarios. A quantitative repeated-measures approach was used with a convenience sample of 12 U.S. Army soldiers ages 18 to 34 years.
C1 [Scribner, David R.] US Army, Res Lab, Aberdeen, MD USA.
RP Scribner, DR (reprint author), US Army, Res Lab, Human Res & Engn Direcorate, 459 Mulberry Rd, Aberdeen Proving Ground, MD 21005 USA.
EM david.r.scribner.civ@mail.mil
NR 47
TC 2
Z9 2
U1 3
U2 5
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1555-3434
EI 2169-5032
J9 J Cogn Eng Decis Mak
JI J. Cogn. Eng. Decis. Mak.
PD MAR
PY 2016
VL 10
IS 1
BP 3
EP 13
DI 10.1177/1555343415608974
PG 11
WC Psychology, Experimental
SC Psychology
GA DK1GT
UT WOS:000374661200001
ER
PT J
AU Gailani, JZ
Lackey, TC
King, DB
Bryant, D
Kim, SC
Shafer, DJ
AF Gailani, Joseph Z.
Lackey, Tahirih C.
King, David B., Jr.
Bryant, Duncan
Kim, Sung-Chan
Shafer, Deborah J.
TI Predicting dredging-associated effects to coral reefs in Apra Harbor,
Guam - Part 1: Sediment exposure modeling
SO JOURNAL OF ENVIRONMENTAL MANAGEMENT
LA English
DT Article
DE Dredging; Exposure; Coral; Computer modeling; Deposition; Sedimentation
rate; Suspended sediment concentration
ID NEW-CALEDONIA; TRANSPORT; LAGOON; BAY
AB Model studies were conducted to investigate the potential coral reef sediment exposure from dredging associated with proposed development of a deepwater wharf in Apra Harbor, Guam. The Particle Tracking Model (PTM) was applied to quantify the exposure of coral reefs to material suspended by the dredging operations at two alternative sites. Key PTM features include the flexible capability of continuous multiple releases of sediment parcels, control of parcel/substrate interaction, and the ability to efficiently track vast numbers of parcels. This flexibility has facilitated simulating the combined effects of sediment released from clamshell dredging and chiseling within Apra Harbor. Because the rate of material released into the water column by some of the processes is not well understood or known a priori, the modeling approach was to bracket parameters within reasonable ranges to produce a suite of potential results from multiple model runs. Sensitivity analysis to model parameters is used to select the appropriate parameter values for bracketing. Data analysis results include mapping the time series and the maximum values of sedimentation, suspended sediment concentration, and deposition rate. Data were used to quantify various exposure processes that affect coral species in Apra Harbor. The goal of this research is to develop a robust methodology for quantifying and bracketing exposure mechanisms to coral (or other receptors) from dredging operations. These exposure values were utilized in an ecological assessment to predict effects (coral reef impacts) from various dredging scenarios. (C) 2015 Published by Elsevier Ltd.
C1 [Gailani, Joseph Z.; Lackey, Tahirih C.; King, David B., Jr.; Bryant, Duncan; Kim, Sung-Chan; Shafer, Deborah J.] US Army Corps Engineers, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
[Shafer, Deborah J.] 6544 Crowfoot Rd, Trail, OR 97541 USA.
RP Gailani, JZ (reprint author), US Army Corps Engineers, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM joe.Z.Gailani@usace.army.mil; DrDeborahShafer@gmail.com
FU Naval Facility Engineering Command; US Army Corps of Engineers Dredging
Operations and Environmental Research Program; Dredging Operations and
Technical Support Program
FX Partial funding for this study was provided by Naval Facility
Engineering Command. Additional funding was provided by the US Army
Corps of Engineers Dredging Operations and Environmental Research
Program, and the Dredging Operations and Technical Support Program.
Naval Facility Engineering Command was not involved in the data
collection, analysis and interpretation or writing of this manuscript.
Approval to publish this manuscript has been granted by Naval Facility
Engineering Command.
NR 26
TC 1
Z9 1
U1 2
U2 8
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0301-4797
EI 1095-8630
J9 J ENVIRON MANAGE
JI J. Environ. Manage.
PD MAR 1
PY 2016
VL 168
BP 16
EP 26
DI 10.1016/j.jenvman.2015.10.027
PG 11
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA DL6EJ
UT WOS:000375732100003
PM 26692413
ER
PT J
AU Nelson, DS
McManus, J
Richmond, RH
King, DB
Gailani, JZ
Lackey, TC
Bryant, D
AF Nelson, Deborah Shafer
McManus, John
Richmond, Robert H.
King, David B., Jr.
Gailani, Joe Z.
Lackey, Tahirih C.
Bryant, Duncan
TI Predicting dredging-associated effects to coral reefs in Apra Harbor,
Guam - Part 2: Potential coral effects
SO JOURNAL OF ENVIRONMENTAL MANAGEMENT
LA English
DT Article
DE Dredging; Turbidity; Sedimentation rate; Deposition; Coral threshold
responses; Stoplight indicators
ID SEDIMENTATION; ORGANISMS; POLLUTION
AB Coral reefs are in decline worldwide due to anthropogenic stressors including reductions in water and substratum quality. Dredging results in the mobilization of sediments, which can stress and kill corals via increasing turbidity, tissue damage and burial. The Particle Tracking Model (PTM) was applied to predict the potential impacts of dredging-associated sediment exposure on the coral reef ecosystems of Apra Harbor, Guam. The data were interpreted using maps of bathymetry and coral abundance and distribution in conjunction with impact parameters of suspended sediment concentration (turbidity) and sedimentation using defined coral response thresholds. The results are presented using a "stoplight" model of negligible or limited impacts to coral reefs (green), moderate stress from which some corals would be expected to recover while others would not (yellow) and severe stress resulting in mortality (red). The red conditions for sediment deposition rate and suspended sediment concentration (SSC) were defined as values exceeding 25 mg cm(-2) d(-1) over any 30 day window and >20 mg/l for any 18 days in any 90 day period over a column of water greater than 2 m, respectively. The yellow conditions were defined as values >10 mg cm(-2) d(-1) and <25 mg cm(-2) d(-1) over any 30 day period, and as 20% of 3 months' concentration exceeding 10 mg/l for the deposition and SSC, respectively. The model also incorporates the potential for cumulative effects on the assumption that even sub-lethal stress levels can ultimately lead to mortality in a multi-stressor system. This modeling approach can be applied by resource managers and regulatory agencies to support management decisions related to planning, site selection, damage reduction, and compensatory mitigation. Published by Elsevier Ltd.
C1 [Nelson, Deborah Shafer; King, David B., Jr.; Gailani, Joe Z.; Lackey, Tahirih C.; Bryant, Duncan] US Army Corps Engineers, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS USA.
[McManus, John] Univ Miami, 4600 Rickenbacker Causeway, Miami, FL USA.
[Richmond, Robert H.] Univ Hawaii Manoa, Kewalo Marine Lab, 41 Ahui St, Honolulu, HI 96822 USA.
RP Nelson, DS (reprint author), US Army Corps Engineers, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS USA.
EM DrDeborahShafer@gmail.com
FU Naval Facility Engineering Command; US Army Corps of Engineers Dredging
Operations and Environmental Research Program; Dredging Operations and
Technical Support Programs
FX Partial funding for this study was provided by Naval Facility
Engineering Command. Additional funding was provided by the US Army
Corps of Engineers Dredging Operations and Environmental Research
Program, and the Dredging Operations and Technical Support Programs.
Naval Facility Engineering Command was not involved in the data
collection, analysis and interpretation or writing of this manuscript.
Approval to publish this manuscript has been granted by Naval Facility
Engineering Command.
NR 29
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U1 2
U2 5
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0301-4797
EI 1095-8630
J9 J ENVIRON MANAGE
JI J. Environ. Manage.
PD MAR 1
PY 2016
VL 168
BP 111
EP 122
DI 10.1016/j.jenvman.2015.10.025
PG 12
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA DL6EJ
UT WOS:000375732100013
PM 26704453
ER
PT J
AU Jacobs, K
Tezak, N
Mabuchi, H
Balu, R
AF Jacobs, Kurt
Tezak, Nikolas
Mabuchi, Hideo
Balu, Radhakrishnan
TI All-mechanical quantum noise cancellation for accelerometry: broadband
with momentum measurements, narrow band without
SO JOURNAL OF OPTICS
LA English
DT Article
DE quantum metrology; optomechanics; force sensing; acelerometry; quantum
nanoelectromechanics; continuous measurement
ID RADIATION-PRESSURE; SQUEEZED STATES; OSCILLATOR
AB We show that the ability to make direct measurements of momentum, in addition to the usual direct measurements of position, allows a simple configuration of two identical mechanical oscillators to be used for broadband back-action-free force metrology. This would eliminate the need for an optical reference oscillator in the scheme of Tsang and Caves (2010 Phys. Rev. Lett.. 105 123601), along with its associated disadvantages. We also show that if one is restricted to position measurements alone then two copies of the same two-oscillator configuration can be used for narrow-band back-action-free force metrology.
C1 [Jacobs, Kurt; Balu, Radhakrishnan] US Army Res Lab, Computat & Informat Sci Directorate, Adelphi, MD 20783 USA.
[Jacobs, Kurt] Univ Massachusetts, Dept Phys, Boston, MA 02125 USA.
[Jacobs, Kurt] Louisiana State Univ, Hearne Inst Theoret Phys, Baton Rouge, LA 70803 USA.
[Tezak, Nikolas; Mabuchi, Hideo] Stanford Univ, Edward L Ginzton Lab, Stanford, CA 94305 USA.
RP Jacobs, K (reprint author), US Army Res Lab, Computat & Informat Sci Directorate, Adelphi, MD 20783 USA.; Jacobs, K (reprint author), Univ Massachusetts, Dept Phys, Boston, MA 02125 USA.; Jacobs, K (reprint author), Louisiana State Univ, Hearne Inst Theoret Phys, Baton Rouge, LA 70803 USA.
EM kurt.jacobs@umb.edu
NR 29
TC 0
Z9 0
U1 2
U2 4
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 2040-8978
EI 2040-8986
J9 J OPTICS-UK
JI J. Opt.
PD MAR
PY 2016
VL 18
IS 3
AR 034002
DI 10.1088/2040-8978/18/3/034002
PG 8
WC Optics
SC Optics
GA DL6LF
UT WOS:000375750000004
ER
PT J
AU Andrews, ES
Turell, MJ
AF Andrews, Elizabeth S.
Turell, Michael J.
TI EFFECT OF HOLDING CONDITIONS ON THE DETECTION OF CHIKUNGUNYA AND
VENEZUELAN EQUINE ENCEPHALITIS VIRUSES IN MOSQUITO POOLS
SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION
LA English
DT Article
DE Arbovirus; reverse transcriptase-quantitative polymerase chain reaction;
stability; temperature
ID POLYMERASE-CHAIN-REACTION; AEDES-AEGYPTI DIPTERA; VIRAL-RNA; JAPANESE
ENCEPHALITIS; PERSISTENCE; AUSTRALIA; STORAGE
AB Emerging and re-emerging arboviruses continue to be a threat to global public health, and viral surveillance of mosquito populations is critical for mosquito control operations. Due to the tropical climate of many of the affected areas, it may be difficult to maintain a cold chain as the samples travel from collection sites to laboratories for testing. We determined how suboptimal holding temperatures affected the ability to detect viruses in pools of mosquitoes. Adult female Aedes albopictus and Ae. taeniorhynchus individuals were inoculated with chikungunya virus or Venezuelan equine encephalitis virus suspensions, respectively, and placed at 26 degrees C for 8 days. One infected mosquito was then added to a vial of 24 negative mosquitoes and held at -80 degrees C, -20 degrees C, 4 degrees C, 22 degrees C, or 35 degrees C for up to 14 days. Mosquito pools were analyzed for both infectious virus by plaque assay and for viral ribonucleic acid (RNA) with reverse transcriptase quantitative polymerase chain reaction (RT-qPCR). At higher temperatures, the amount of infectious virus decreased rapidly, but viruses in samples held at 4 degrees C or lower remained relatively stable. In contrast, viral RNA was detectable from pools held at all temperatures and holding times by RT-qPCR. Cycle threshold (Ct) values increased as temperatures and holding times increased. These findings suggest that if viral RNA detection is the goal of surveillance efforts, then mosquito pools do not require storage at 4 degrees C. This enhances the feasibility of field-based arbovirus surveillance programs in which maintaining a cold chain may not be a possibility.
C1 [Andrews, Elizabeth S.; Turell, Michael J.] US Army, Med Res Inst Infect Dis, Div Virol, 1425 Porter St, Ft Detrick, MD 21702 USA.
RP Andrews, ES (reprint author), US Army, Med Res Inst Infect Dis, Div Virol, 1425 Porter St, Ft Detrick, MD 21702 USA.
NR 15
TC 0
Z9 0
U1 0
U2 0
PU AMER MOSQUITO CONTROL ASSOC
PI MOUNT LAUREL
PA 15000 COMMERCE PARKWAY, SUITE C, MOUNT LAUREL, NJ 08054 USA
SN 8756-971X
EI 1943-6270
J9 J AM MOSQUITO CONTR
JI J. Am. Mosq. Control Assoc.
PD MAR
PY 2016
VL 32
IS 1
BP 51
EP 54
PG 4
WC Entomology
SC Entomology
GA DJ9CA
UT WOS:000374510400006
PM 27105216
ER
PT J
AU Jahnke, JP
Cornejo, JA
Sumner, JJ
Schuler, AJ
Atanassov, P
Ista, LK
AF Jahnke, Justin P.
Cornejo, Jose A.
Sumner, James J.
Schuler, Andrew J.
Atanassov, Plamen
Ista, Linnea K.
TI Conjugated gold nanoparticles as a tool for probing the bacterial cell
envelope: The case of Shewanella oneidensis MR-1
SO BIOINTERPHASES
LA English
DT Article
ID SELF-ASSEMBLED MONOLAYERS; OLIGO(ETHYLENE GLYCOL); SURFACE-PROPERTIES;
ESCHERICHIA-COLI; OUTER-MEMBRANE; ATTACHMENT; BIOFILMS; ADHESION;
PROTEINS; RESISTANCE
AB The bacterial cell envelope forms the interface between the interior of the cell and the outer world and is, thus, the means of communication with the environment. In particular, the outer cell surface mediates the adhesion of bacteria to the surface, the first step in biofilm formation. While a number of ligand-based interactions are known for the attachment process in commensal organisms and, as a result, opportunistic pathogens, the process of nonspecific attachment is thought to be mediated by colloidal, physiochemical, interactions. It is becoming clear, however, that colloidal models ignore the heterogeneity of the bacterial surface, and that the so-called nonspecific attachment may be mediated by specific regions of the cell surface, whether or not the relevant interaction is ligand-mediate. The authors introduce surface functionalized gold nanoparticles to probe the surface chemistry of Shewanella oneidensis MR-1 as it relates to surface attachment to x-substituted alkanethiolates self-assembled monolayers (SAMs). A linear relationship between the attachment of S. oneidensis to SAM modified planar substrates and the number of similarly modified nanoparticles attached to the bacterial surfaces was demonstrated. In addition, the authors demonstrate that carboxylic acid-terminated nanoparticles attach preferentially to the subpolar region of the S. oneidensis and obliteration of that binding preference corresponds in loss of attachment to carboxylic acid terminated SAMs. Moreover, this region corresponds to suspected functional regions of the S. oneidensis surface. Because this method can be employed over large numbers of cells, this method is expected to be generally applicable for understanding cell surface organization across populations. (C) 2016 Author(s).
C1 [Jahnke, Justin P.; Sumner, James J.] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
[Cornejo, Jose A.; Atanassov, Plamen; Ista, Linnea K.] Univ New Mexico, Ctr Biomed Engn, Ctr Microengn Mat, Dept Biol Engn, Albuquerque, NM 87131 USA.
[Schuler, Andrew J.] Univ New Mexico, Dept Civil Engn, Albuquerque, NM 87131 USA.
RP Ista, LK (reprint author), Univ New Mexico, Ctr Biomed Engn, Ctr Microengn Mat, Dept Biol Engn, Albuquerque, NM 87131 USA.
EM lkista@unm.edu
FU Army Research Office [W911NF1210208]; Defense Threat Reduction Agency
[HDTRA-1-11-1-0004]; U.S. Army Research Laboratory Postdoctoral
Fellowship Program
FX Shewanella oneidensis MR-1 and mutant strains used in this work was the
kind gift of M. Y. Naggar at USC. The authors thank Christian J. Sund of
the U.S. Army Research Laboratory for helpful discussions. This work was
supported by grants from the Army Research Office (Grant No.
W911NF1210208) and the Defense Threat Reduction Agency (Grant No.
HDTRA-1-11-1-0004). J.P.J. acknowledges support from the U.S. Army
Research Laboratory Postdoctoral Fellowship Program administered by the
Oak Ridge Associated Universities.
NR 51
TC 0
Z9 0
U1 6
U2 15
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 1934-8630
EI 1559-4106
J9 BIOINTERPHASES
JI Biointerphases
PD MAR
PY 2016
VL 11
IS 1
AR 011003
DI 10.1116/1.4939244
PG 7
WC Biophysics; Materials Science, Biomaterials
SC Biophysics; Materials Science
GA DK5TB
UT WOS:000374982200003
PM 26746161
ER
PT J
AU Diefenderfer, HL
Johnson, GE
Thom, RM
Buenau, KE
Weitkamp, LA
Woodley, CM
Borde, AB
Kropp, RK
AF Diefenderfer, Heida L.
Johnson, Gary E.
Thom, Ronald M.
Buenau, Kate E.
Weitkamp, Laurie A.
Woodley, Christa M.
Borde, Amy B.
Kropp, Roy K.
TI Evidence-based evaluation of the cumulative effects of ecosystem
restoration
SO ECOSPHERE
LA English
DT Article
DE causal criteria; critical thinking; cumulative effects; evidence-based
medicine; fisheries; floodplain food web; habitat connectivity;
hydropower mitigation; large-scale ecosystem restoration; salmon
recovery; sustainability science; systematic review; tidal wetlands
ID JUVENILE CHINOOK SALMON; LOWER COLUMBIA RIVER; RESTORED ESTUARINE
WETLAND; DIEL FEEDING CHRONOLOGY; ONCORHYNCHUS-KISUTCH; COHO SALMON;
FOOD WEBS; SEASONAL FLOODPLAIN; ADAPTIVE MANAGEMENT; GASTRIC EVACUATION
AB This study adapts and applies the evidence-based approach for causal inference, a medical standard, to the restoration and sustainable management of large-scale aquatic ecosystems. Despite long-term investments in restoring aquatic ecosystems, it has proven difficult to adequately synthesize and evaluate program outcomes, and no standard method has been adopted. Complex linkages between restorative actions and ecosystem responses at a landscape scale make evaluations problematic and most programs focus on monitoring and analysis. Herein, we demonstrate a new transdisciplinary approach integrating techniques from evidence-based medicine, critical thinking, and cumulative effects assessment. Tiered hypotheses about the effects of landscape-scale restorative actions are identified using an ecosystem conceptual model. The systematic literature review, a health sciences standard since the 1960s, becomes just one of seven lines of evidence assessed collectively, using critical thinking strategies, causal criteria, and cumulative effects categories. As a demonstration, we analyzed data from 166 locations on the Columbia River and estuary representing 12 indicators of habitat and fish response to floodplain restoration actions intended to benefit culturally and economically important, threatened and endangered salmon. Synthesis of the lines of evidence demonstrated that hydrologic reconnection promoted macrodetritis export, prey availability, and juvenile fish access and feeding. Upon evaluation, the evidence was sufficient to infer cross-boundary, indirect, compounding, and delayed cumulative effects, and suggestive of nonlinear, landscape-scale, and spatial density effects. Therefore, on the basis of causal inferences regarding food-web functions, we concluded that the restoration program is having a cumulative beneficial effect on juvenile salmon. The lines of evidence developed are transferable to other ecosystems: modeling of cumulative net ecosystem improvement, physical modeling of ecosystem controlling factors, meta-analysis of restoration action effectiveness, analysis of data on target species, research on critical ecological uncertainties, evidence-based review of the literature, and change analysis on the landscape setting. As with medicine, the science of ecological restoration needs scientific approaches to management decisions, particularly because the consequences affect species extinctions and the availability of ecosystem services. This evidence-based approach will enable restoration in complex coastal, riverine, and tidal-fluvial ecosystems like the lower Columbia River to be evaluated when data have accumulated without sufficient synthesis.
C1 [Diefenderfer, Heida L.; Johnson, Gary E.; Thom, Ronald M.; Buenau, Kate E.; Woodley, Christa M.; Borde, Amy B.; Kropp, Roy K.] Pacific NW Natl Lab, Marine Sci Lab, 1529 West Sequim Bay Rd, Sequim, WA 98382 USA.
[Weitkamp, Laurie A.] NOAA, NW Fisheries Sci Ctr, Newport, OR 97365 USA.
[Woodley, Christa M.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Diefenderfer, HL (reprint author), Pacific NW Natl Lab, Marine Sci Lab, 1529 West Sequim Bay Rd, Sequim, WA 98382 USA.
EM heida.diefenderfer@pnnl.gov
OI Buenau, Kate/0000-0003-2156-7260
FU U.S. Army Corps of Engineers, Portland District; NOAA Fisheries;
Northwest Fisheries Science Center; U.S. Army Corps of Engineers, Walla
Walla District
FX We appreciate the financial support of the U.S. Army Corps of Engineers,
Portland District. We are grateful to biologists B Ebberts, C
Studebaker, and C Roegner for their leadership. Data collection by L
Weitkamp was funded by the NOAA Fisheries, Northwest Fisheries Science
Center and collection by C Woodley was funded by U.S. Army Corps of
Engineers, Portland District and Walla Walla District. We thank A
Cameron, A Coleman, V Cullinan, E Dawley, B Ebberts, M Hudson, J
Johnson, L Johnson, K MacNeale, K Marcoe, R McNatt, D Putman, M Russell,
N Sather, J Skalski, K Sobocinski, and A Uber for their contributions
and others for help in the field and laboratory. HLD thanks B. Brehm, D.
Qualley, and P. Steinberger for guidance on critical reasoning and
judgment.
NR 136
TC 3
Z9 3
U1 25
U2 50
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2150-8925
J9 ECOSPHERE
JI Ecosphere
PD MAR
PY 2016
VL 7
IS 3
AR e01242
DI 10.1002/ecs2.1242
PG 33
WC Ecology
SC Environmental Sciences & Ecology
GA DK4OB
UT WOS:000374896800014
ER
PT J
AU Welton, MD
AF Welton, Mark D.
TI Doubt in Islamic Law: A History of Legal Maxims, Interpretation, and
Islamic Criminal Law
SO MIDDLE EAST JOURNAL
LA English
DT Book Review
C1 [Welton, Mark D.] US Mil Acad, West Point, NY 10996 USA.
RP Welton, MD (reprint author), US Mil Acad, West Point, NY 10996 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU MIDDLE EAST INST
PI WASHINGTON
PA 1761 N ST NW, CIRCULATION DEPT, WASHINGTON, DC 20036-2882 USA
SN 0026-3141
EI 1940-3461
J9 MIDDLE EAST J
JI Middle East J.
PD SPR
PY 2016
VL 70
IS 2
BP 343
EP 344
PG 2
WC Area Studies
SC Area Studies
GA DK9FQ
UT WOS:000375236600017
ER
PT J
AU Fegyveresi, JM
Alley, RB
Fitzpatrick, JJ
Cuffey, KM
McConnell, JR
Voigt, DE
Spencer, MK
Stevens, NT
AF Fegyveresi, John M.
Alley, Richard B.
Fitzpatrick, Joan J.
Cuffey, Kurt M.
McConnell, Joseph R.
Voigt, Donald E.
Spencer, Matthew K.
Stevens, Nathan T.
TI Five millennia of surface temperatures and ice core bubble
characteristics from the WAIS Divide deep core, West Antarctica
SO PALEOCEANOGRAPHY
LA English
DT Article
DE ice cores; bubble number density; ice core bubbles; holocene climate;
paleoclimate reconstruction; bubble characteristics
ID LOCALLY WEIGHTED REGRESSION; AIR BUBBLES; PHYSICAL-PROPERTIES; SHEET
SURFACE; MELT LAYERS; SIPLE DOME; POLAR ICE; FIRN; NUMBER; DENSIFICATION
AB Bubble number densities from the West Antarctic Ice Sheet (WAIS) Divide deep core in West Antarctica record relatively stable temperatures during the middle Holocene followed by late Holocene cooling. We measured bubble number density, shape, size, and arrangement on new samples of the main WAIS Divide deep core WDC06A from similar to 580m to similar to 1600 depth. The bubble size, shape, and arrangement data confirm that the samples satisfy the requirements for temperature reconstructions. A small correction for cracks formed after core recovery allows extension of earlier work through the brittle ice zone, and a site-specific calibration reduces uncertainties. Using an independently constructed accumulation rate history and a steady state bubble number density model, we determined a temperature reconstruction that agrees closely with other independent estimates, showing a stable middle Holocene, followed by a cooling of similar to 1.25 degrees C in the late Holocene. Over the last similar to 5 millennia, accumulation has been higher during warmer times by similar to 12%degrees C-1, somewhat stronger than for thermodynamic control alone, suggesting dynamic processes.
C1 [Fegyveresi, John M.; Alley, Richard B.; Voigt, Donald E.; Stevens, Nathan T.] Penn State Univ, Dept Geosci, University Pk, PA 16802 USA.
[Fegyveresi, John M.; Alley, Richard B.; Voigt, Donald E.; Stevens, Nathan T.] Penn State Univ, Earth & Environm Syst Inst, University Pk, PA 16802 USA.
[Fegyveresi, John M.] Cold Reg Res & Engn Lab, Terr & Cryospher Sci Branch, Hanover, NH USA.
[Fitzpatrick, Joan J.] US Geol Survey, Geosci & Environm Change Sci Ctr, Box 25046, Denver, CO 80225 USA.
[Cuffey, Kurt M.] Univ Calif Berkeley, Dept Earth & Planetary Sci, Berkeley, CA 94720 USA.
[McConnell, Joseph R.] Univ Nevada, Desert Res Inst, Div Hydrol Sci, Reno, NV 89506 USA.
[Spencer, Matthew K.] Lake Super State Univ, Sch Phys Sci, Sault Ste Marie, ON, Canada.
RP Fegyveresi, JM (reprint author), Penn State Univ, Dept Geosci, University Pk, PA 16802 USA.; Fegyveresi, JM (reprint author), Penn State Univ, Earth & Environm Syst Inst, University Pk, PA 16802 USA.; Fegyveresi, JM (reprint author), Cold Reg Res & Engn Lab, Terr & Cryospher Sci Branch, Hanover, NH USA.
EM john.m.fegyveresi@usace.army.mil
FU U.S. Geological Survey Climate and Land Use Change Research and
Development Program; U.S. National Science Foundation Division of Polar
Programs [0539578, 1043528, 1043313, 0539232, 0537661, 0839093, 1142166]
FX We acknowledge the following funding sources for support of this work:
U.S. Geological Survey Climate and Land Use Change Research and
Development Program, and the U.S. National Science Foundation Division
of Polar Programs grants 0539578, 1043528, 1043313, 0539232, 0537661,
0839093, and 1142166. We also acknowledge the staff of the U.S. National
Ice Core Laboratory in Denver, Colorado, E. Cravens, the WAIS Divide
Science Coordination Office at the University of New Hampshire, and the
Ice Drilling Design and Operations group at the University of Wisconsin,
whose phenomenal success in designing and operating the new Deep Ice
Sheet Coring (DISC) drill has reinvigorated U.S. deep ice coring
efforts. We thank numerous colleagues in the WAIS Divide project,
especially C. Buizert, G. Clow, and E. Steig. We also acknowledge L.
Layman, O. Maselli, D. Pasteris, and M. Sigl at the Desert Research
Institute of Reno, Nevada, for their assistance with chemical analyses
of ice samples. Lastly, we thank our three reviewers, whose thoughtful
suggestions and questions served to clarify and improve this manuscript.
Data policy: All data presented here are available via download from
NSIDC (http://nsidc.org) or from the WAIS Divide data portal
(http://waisdivide.unh.edu).
NR 58
TC 1
Z9 1
U1 6
U2 6
PU AMER GEOPHYSICAL UNION
PI WASHINGTON
PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA
SN 0883-8305
EI 1944-9186
J9 PALEOCEANOGRAPHY
JI Paleoceanography
PD MAR
PY 2016
VL 31
IS 3
BP 416
EP 433
DI 10.1002/2015PA002851
PG 18
WC Geosciences, Multidisciplinary; Oceanography; Paleontology
SC Geology; Oceanography; Paleontology
GA DJ6SU
UT WOS:000374344000005
ER
PT J
AU Clark, MP
Schaefli, B
Schymanski, SJ
Samaniego, L
Luce, CH
Jackson, BM
Freer, JE
Arnold, JR
Moore, RD
Istanbulluoglu, E
Ceola, S
AF Clark, Martyn P.
Schaefli, Bettina
Schymanski, Stanislaus J.
Samaniego, Luis
Luce, Charles H.
Jackson, Bethanna M.
Freer, Jim E.
Arnold, Jeffrey R.
Moore, R. Dan
Istanbulluoglu, Erkan
Ceola, Serena
TI Improving the theoretical underpinnings of process-based hydrologic
models
SO WATER RESOURCES RESEARCH
LA English
DT Editorial Material
DE hydrologic theory; multiple hypotheses; model evaluation; uncertainty
ID DYNAMIC TOPMODEL; WATERSHED THERMODYNAMICS; ALTERNATIVE BLUEPRINT;
ENVIRONMENTAL-MODELS; UNIFYING FRAMEWORK; FORESTED CATCHMENT; STORAGE
DYNAMICS; RUNOFF PROCESSES; MULTIPLE SCALES; STATE VARIABLES
AB In this Commentary, we argue that it is possible to improve the physical realism of hydrologic models by making better use of existing hydrologic theory. We address the following questions: (1) what are some key elements of current hydrologic theory; (2) how can those elements best be incorporated where they may be missing in current models; and (3) how can we evaluate competing hydrologic theories across scales and locations? We propose that hydrologic science would benefit from a model-based community synthesis effort to reframe, integrate, and evaluate different explanations of hydrologic behavior, and provide a controlled avenue to find where understanding falls short.
C1 [Clark, Martyn P.] Natl Ctr Atmospher Res, Res Applicat Lab, POB 3000, Boulder, CO 80307 USA.
[Schaefli, Bettina] Ecole Polytech Fed Lausanne, Sch Architecture Civil & Environm Engn, Lausanne, Switzerland.
[Schaefli, Bettina] Univ Lausanne, Fac Geosci & Environm, CH-1015 Lausanne, Switzerland.
[Schymanski, Stanislaus J.] Swiss Fed Inst Technol, Dept Environm Syst Sci, Zurich, Switzerland.
[Samaniego, Luis] UFZ Helmholtz Ctr Environm Res, CHS, Leipzig, Germany.
[Luce, Charles H.] USDA, Forest Serv, Res & Dev, Boise, ID USA.
[Jackson, Bethanna M.] Victoria Univ Wellington, Sch Geog Environm & Earth Sci, Wellington, New Zealand.
[Freer, Jim E.] Univ Bristol, Sch Geog Sci, Bristol, Avon, England.
[Arnold, Jeffrey R.] US Army Corps Engineers, IWR JISAO, Seattle, WA USA.
[Moore, R. Dan] Univ British Columbia, Dept Geog, Vancouver, BC, Canada.
[Istanbulluoglu, Erkan] Univ Washington, Coll Engn, Dept Civil & Environm Engn, Seattle, WA 98195 USA.
[Ceola, Serena] Univ Bologna, DICAM, Bologna, Italy.
RP Clark, MP (reprint author), Natl Ctr Atmospher Res, Res Applicat Lab, POB 3000, Boulder, CO 80307 USA.
EM mclark@ucar.edu
RI Freer, Jim/C-7335-2009; Samaniego, Luis/G-8651-2011; Schymanski,
Stanislaus/A-5303-2012; Schaefli, Bettina/B-2069-2010; Luce,
Charles/A-9267-2008
OI Samaniego, Luis/0000-0002-8449-4428; Schymanski,
Stanislaus/0000-0002-0950-2942; Schaefli, Bettina/0000-0003-1140-6244;
Luce, Charles/0000-0002-6938-9662
NR 144
TC 4
Z9 4
U1 6
U2 9
PU AMER GEOPHYSICAL UNION
PI WASHINGTON
PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA
SN 0043-1397
EI 1944-7973
J9 WATER RESOUR RES
JI Water Resour. Res.
PD MAR
PY 2016
VL 52
IS 3
BP 2350
EP 2365
DI 10.1002/2015WR017910
PG 16
WC Environmental Sciences; Limnology; Water Resources
SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water
Resources
GA DK1WR
UT WOS:000374706300043
ER
PT J
AU Carlsson, AH
Fletcher, JL
Rose, LF
Medina, JL
Leung, KP
Chan, RK
AF Carlsson, A. H.
Fletcher, J. L.
Rose, L. F.
Medina, J. L.
Leung, K. P.
Chan, R. K.
TI HYPERTROPHIC-LIKE SCAR FORMATION FOLLOWING PARTIAL THICKNESS BURN OR
SKIN LOSS: A PORCINE MODEL
SO WOUND REPAIR AND REGENERATION
LA English
DT Meeting Abstract
C1 [Carlsson, A. H.; Fletcher, J. L.; Rose, L. F.; Medina, J. L.; Leung, K. P.; Chan, R. K.] US Army Inst Surg Res, Dent & Craniofacial Trauma Res & Tissue Regenerat, Jbsa Ft Sam Houston, TX USA.
[Carlsson, A. H.; Fletcher, J. L.; Rose, L. F.; Chan, R. K.] US Army Inst Surg Res, Qual Skin Collaborat Adv Reconstruct & Regenerat, Jbsa Ft Sam Houston, TX USA.
[Chan, R. K.] US Army Inst Surg Res, Clin Div, Jbsa Ft Sam Houston, TX USA.
[Chan, R. K.] US Army Inst Surg Res, Burn Ctr, Jbsa Ft Sam Houston, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAR-APR
PY 2016
VL 24
IS 2
BP A4
EP A5
PG 2
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA DK8DP
UT WOS:000375157700018
ER
PT J
AU Chen, L
Zhou, J
Zhao, Y
Fine, D
Nagaraja, S
Mitrophanov, AY
Reifman, J
DiPietro, LA
AF Chen, L.
Zhou, J.
Zhao, Y.
Fine, D.
Nagaraja, S.
Mitrophanov, A. Y.
Reifman, J.
DiPietro, L. A.
TI COLLAGEN SYNTHESIS AND DEPOSITION IN SKIN WOUNDS OF MAC-1 DEFICIENT MICE
SO WOUND REPAIR AND REGENERATION
LA English
DT Meeting Abstract
C1 [Chen, L.; Zhou, J.; Zhao, Y.; Fine, D.; DiPietro, L. A.] Univ Illinois, Ctr Wound Healing & Tissue Regenerat Periodont, Chicago, IL USA.
[Nagaraja, S.; Mitrophanov, A. Y.; Reifman, J.] US Army Med Res & Mat Command, Dept Def, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAR-APR
PY 2016
VL 24
IS 2
BP A5
EP A5
PG 1
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA DK8DP
UT WOS:000375157700021
ER
PT J
AU Hall, CL
Wells, AR
Leung, KP
AF Hall, C. L.
Wells, A. R.
Leung, K. P.
TI PIRFENIDONE MODULATES THE TGF-beta 1-INDUCED PROFIBROTIC PHENOTYPE IN
HUMAN DERMAL FIBROBLASTS
SO WOUND REPAIR AND REGENERATION
LA English
DT Meeting Abstract
C1 [Hall, C. L.; Wells, A. R.; Leung, K. P.] US Army, Dent & Craniofacial Trauma Res & Tissue Regenerat, Inst Surg Res, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAR-APR
PY 2016
VL 24
IS 2
BP A10
EP A10
PG 1
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA DK8DP
UT WOS:000375157700044
ER
PT J
AU Karna, S
Tsute, C
D'Arpa, P
Liwu, Q
Ping, C
Fourcaudot, AB
Kazuyoshi, Y
Jeffrey, N
Abercrombie, JJ
Tao, Y
Leung, KP
AF Karna, S.
Tsute, C.
D'Arpa, P.
Liwu, Q.
Ping, C.
Fourcaudot, A. B.
Kazuyoshi, Y.
Jeffrey, N.
Abercrombie, J. J.
Tao, Y.
Leung, K. P.
TI HOST GENOMIC RESPONSES TO PSEUDOMONAS AERUGINOSA WOUND INFECTIONS
SO WOUND REPAIR AND REGENERATION
LA English
DT Meeting Abstract
C1 [Karna, S.; Liwu, Q.; Ping, C.; Fourcaudot, A. B.; Kazuyoshi, Y.; Jeffrey, N.; Abercrombie, J. J.; Tao, Y.; Leung, K. P.] US Army, Inst Surg Reasearch Dent & Craniofacial Trauma Re, Jbsa Ft Sam Houston, TX USA.
[Tsute, C.] Forsyth Inst, Cambridge, MA USA.
[D'Arpa, P.] US Army, Syst & Integrat Biol Program, Ctr Environm Hlth Res, Frederick, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAR-APR
PY 2016
VL 24
IS 2
BP A14
EP A15
PG 2
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA DK8DP
UT WOS:000375157700062
ER
PT J
AU Medina, JL
Carlsson, AH
Fourcaudot, AB
Leung, KP
AF Medina, J. L.
Carlsson, A. H.
Fourcaudot, A. B.
Leung, K. P.
TI SCALD MODEL OF PARTIAL THICKNESS BURNS IN C57BL/6 MICE
SO WOUND REPAIR AND REGENERATION
LA English
DT Meeting Abstract
C1 [Medina, J. L.; Carlsson, A. H.; Fourcaudot, A. B.; Leung, K. P.] US Army, Inst Surg Res, Dent & Craniofacial Trauma Res & Tissue Regenerat, Ft Sam Houston, TX 78234 USA.
[Carlsson, A. H.] US Army, Inst Surg Res, Qual Skin Collaborat Adv Reconstruct & Regenerat, Ft Sam Houston, TX 78234 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAR-APR
PY 2016
VL 24
IS 2
BP A18
EP A18
PG 1
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA DK8DP
UT WOS:000375157700077
ER
PT J
AU Nagaraja, S
Chen, L
Zhou, J
Zhao, Y
Fine, D
DiPietro, A
Reifman, J
Mitrophanov, AY
AF Nagaraja, S.
Chen, L.
Zhou, J.
Zhao, Y.
Fine, D.
DiPietro, A.
Reifman, J.
Mitrophanov, A. Y.
TI MECHANISTIC DRIVERS AND MOLECULAR INDICATORS OF DELAYED INFLAMMATION
RESOLUTION IN TRAUMATIC WOUNDS
SO WOUND REPAIR AND REGENERATION
LA English
DT Meeting Abstract
C1 [Nagaraja, S.; Reifman, J.; Mitrophanov, A. Y.] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, DoD Biotechnol High Performance Comp Software App, Frederick, MD USA.
[Chen, L.; Zhou, J.; Zhao, Y.; Fine, D.; DiPietro, A.] Univ Illinois, Coll Dent, Ctr Wound Healing & Tissue Regenerat, Chicago, IL USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAR-APR
PY 2016
VL 24
IS 2
BP A19
EP A19
PG 1
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA DK8DP
UT WOS:000375157700081
ER
PT J
AU Olekson, MA
Savage, PB
Leung, KP
AF Olekson, M. A.
Savage, P. B.
Leung, K. P.
TI ANTI-BIOFILM PEPTIDES AND PEPTIDE-MIMICS STIMULATE WOUND HEALING
PROCESSES IN VITRO
SO WOUND REPAIR AND REGENERATION
LA English
DT Meeting Abstract
C1 [Olekson, M. A.; Leung, K. P.] US Army Inst Surg Res, Dent & Craniofacial Trauma Res & Tissue Regenerat, Ft Sam Houston, TX USA.
[Savage, P. B.] Brigham Young Univ, Dept Chem & Biochem, Provo, UT 84602 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAR-APR
PY 2016
VL 24
IS 2
BP A19
EP A20
PG 2
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA DK8DP
UT WOS:000375157700085
ER
EF